locus-tag	class	description
LA358_00010	COG0137	argininosuccinate synthase activity
LA358_00020	COG0165	Argininosuccinate lyase
LA358_00040	COG3314	Sporulation integral membrane protein YlbJ
LA358_00065	COG3550	peptidyl-serine autophosphorylation
LA358_00070	COG3550	peptidyl-serine autophosphorylation
LA358_00080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LA358_00085	COG2022	thiamine diphosphate biosynthetic process
LA358_00095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA358_00100	COG0352	thiamine-phosphate diphosphorylase activity
LA358_00105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LA358_00125	COG0745	RESPONSE REGULATOR receiver
LA358_00130	COG0642	Histidine kinase
LA358_00135	COG0189	ligase activity
LA358_00150	COG2200	EAL domain
LA358_00155	COG2200	EAL domain
LA358_00160	COG1049	propionate catabolic process, 2-methylcitrate cycle
LA358_00165	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA358_00170	COG0840	transmembrane signaling receptor activity
LA358_00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA358_00185	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA358_00190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LA358_00195	COG2186	Transcriptional regulator
LA358_00220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA358_00225	COG1459	type II secretion system
LA358_00230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LA358_00240	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LA358_00245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LA358_00255	COG0653	protein targeting
LA358_00265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LA358_00270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LA358_00275	COG0849	cell division
LA358_00280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA358_00285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA358_00290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LA358_00295	COG0772	Belongs to the SEDS family
LA358_00300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LA358_00305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA358_00310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA358_00315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA358_00320	COG0768	penicillin binding
LA358_00325	COG3116	cell division
LA358_00330	COG0275	rRNA processing
LA358_00335	COG2001	Belongs to the MraZ family
LA358_00345	COG0741	lytic transglycosylase activity
LA358_00345	COG1388	LysM domain
LA358_00360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA358_00365	COG1191	sigma factor activity
LA358_00390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LA358_00395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA358_00420	COG4786	Flagellar basal body rod
LA358_00420	COG1256	bacterial-type flagellum assembly
LA358_00430	COG1706	bacterial-type flagellum-dependent cell motility
LA358_00435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LA358_00440	COG4786	Flagellar basal body rod
LA358_00450	COG1749	Flagellar hook protein flgE
LA358_00465	COG1815	bacterial-type flagellum-dependent cell motility
LA358_00500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA358_00510	COG1677	Flagellar hook-basal body complex protein FliE
LA358_00535	COG1987	bacterial-type flagellum assembly
LA358_00560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LA358_00565	COG3107	peptidoglycan biosynthetic process
LA358_00570	COG0792	nuclease activity
LA358_00575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA358_00580	COG2823	Periplasmic or secreted lipoprotein
LA358_00585	COG2969	positive regulation of protein catabolic process
LA358_00590	COG0625	glutathione transferase activity
LA358_00595	COG2857	Cytochrome c1
LA358_00600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA358_00605	COG0723	plastoquinol--plastocyanin reductase activity
LA358_00610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LA358_00615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LA358_00620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA358_00630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA358_00635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA358_00640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_00645	COG1660	Displays ATPase and GTPase activities
LA358_00650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_00660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LA358_00665	COG1137	ATPase activity
LA358_00670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA358_00675	COG3117	lipopolysaccharide transmembrane transporter activity
LA358_00680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LA358_00685	COG0517	IMP dehydrogenase activity
LA358_00685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA358_00690	COG1127	ABC transporter
LA358_00695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA358_00700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA358_00705	COG2854	intermembrane phospholipid transfer
LA358_00715	COG5007	Belongs to the BolA IbaG family
LA358_00720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LA358_00725	COG0312	modulator of DNA gyrase
LA358_00730	COG3028	Belongs to the UPF0307 family
LA358_00735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LA358_00745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA358_00750	COG1011	Hydrolase
LA358_00765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LA358_00770	COG0019	diaminopimelate decarboxylase activity
LA358_00780	COG1965	Belongs to the frataxin family
LA358_00785	COG0400	carboxylic ester hydrolase activity
LA358_00790	COG3072	Adenylate cyclase
LA358_00795	COG0181	hydroxymethylbilane synthase activity
LA358_00805	COG2959	enzyme of heme biosynthesis
LA358_00820	COG1494	fructose-1,6-bisphosphatase
LA358_00830	COG1686	Belongs to the peptidase S11 family
LA358_00860	COG0795	lipopolysaccharide-transporting ATPase activity
LA358_00865	COG0795	lipopolysaccharide-transporting ATPase activity
LA358_00870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LA358_00875	COG2927	DNA polymerase III (CHI subunit)
LA358_00880	COG0525	valine-tRNA ligase activity
LA358_00895	COG1247	-acetyltransferase
LA358_00900	COG0753	catalase activity
LA358_00925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA358_00945	COG4533	DNA binding
LA358_00955	COG2873	o-acetylhomoserine
LA358_00980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LA358_00990	COG1175	transmembrane transport
LA358_01015	COG3069	C4-dicarboxylate transmembrane transporter activity
LA358_01030	COG0346	lactoylglutathione lyase activity
LA358_01035	COG1192	Involved in chromosome partitioning
LA358_01040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA358_01045	COG1074	ATP-dependent DNA helicase activity
LA358_01050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA358_01055	COG2259	Doxx family
LA358_01060	COG1741	Belongs to the pirin family
LA358_01070	COG0583	DNA-binding transcription factor activity
LA358_01090	COG4771	TonB-dependent receptor
LA358_01120	COG0203	ribosomal protein L17
LA358_01125	COG0202	RNA polymerase activity
LA358_01130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LA358_01135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LA358_01140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LA358_01145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LA358_01150	COG0201	protein transport
LA358_01155	COG0200	Binds to the 23S rRNA
LA358_01160	COG1841	ribosomal large subunit assembly
LA358_01165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LA358_01170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LA358_01175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LA358_01180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LA358_01185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LA358_01190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LA358_01195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LA358_01200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LA358_01205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LA358_01210	COG0255	Belongs to the universal ribosomal protein uL29 family
LA358_01215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LA358_01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LA358_01225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LA358_01230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LA358_01235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LA358_01240	COG0089	rRNA binding
LA358_01245	COG0088	Forms part of the polypeptide exit tunnel
LA358_01250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LA358_01255	COG0051	transcription antitermination factor activity, RNA binding
LA358_01265	COG2205	protein histidine kinase activity
LA358_01275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA358_01280	COG2183	response to ionizing radiation
LA358_01300	COG0596	Alpha beta hydrolase
LA358_01305	COG1040	competence protein
LA358_01310	COG0316	Belongs to the HesB IscA family
LA358_01310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LA358_01315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LA358_01320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LA358_01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA358_01330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LA358_01335	COG4942	peptidase
LA358_01345	COG1609	Transcriptional regulator
LA358_01350	COG0800	Aldolase
LA358_01355	COG0129	dihydroxy-acid dehydratase activity
LA358_01360	COG3265	gluconokinase activity
LA358_01365	COG2610	gluconate transmembrane transporter activity
LA358_01370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA358_01375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA358_01385	COG0456	acetyltransferase
LA358_01390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA358_01395	COG1490	D-aminoacyl-tRNA deacylase activity
LA358_01400	COG1295	ribonuclease BN
LA358_01405	COG0281	malic enzyme
LA358_01410	COG0702	epimerase
LA358_01420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA358_01425	COG0254	rRNA binding
LA358_01435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA358_01440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA358_01450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LA358_01460	COG0514	ATP-dependent DNA helicase (RecQ)
LA358_01465	COG2050	protein possibly involved in aromatic compounds catabolism
LA358_01480	COG2258	MOSC domain
LA358_01485	COG1177	transmembrane transport
LA358_01490	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA358_01495	COG3842	ATPase activity
LA358_01515	COG0174	glutamine synthetase
LA358_01530	COG3045	CreA protein
LA358_01540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA358_01545	COG0443	Heat shock 70 kDa protein
LA358_01555	COG4310	Domain of unknown function (DUF2172)
LA358_01575	COG0366	Alpha amylase catalytic
LA358_01590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA358_01610	COG3250	beta-galactosidase activity
LA358_01615	COG1609	Transcriptional regulator
LA358_01620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA358_01625	COG1085	galactose-1-phosphate uridylyltransferase
LA358_01630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LA358_01635	COG2017	converts alpha-aldose to the beta-anomer
LA358_01640	COG1968	undecaprenyl-diphosphatase activity
LA358_01645	COG0018	arginyl-trna synthetase
LA358_01655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LA358_01660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LA358_01670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_01675	COG1131	(ABC) transporter
LA358_01680	COG0842	Transport permease protein
LA358_01685	COG0842	Transport permease protein
LA358_01690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA358_01705	COG2116	formate transmembrane transporter activity
LA358_01710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA358_01710	COG1648	precorrin-2 dehydrogenase activity
LA358_01715	COG2239	Acts as a magnesium transporter
LA358_01725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LA358_01730	COG2937	Belongs to the GPAT DAPAT family
LA358_01735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LA358_01740	COG3161	chorismate lyase activity
LA358_01745	COG1580	Controls the rotational direction of flagella during chemotaxis
LA358_01760	COG0604	alcohol dehydrogenase
LA358_01765	COG1519	Transferase
LA358_01770	COG0859	PFAM glycosyl transferase family 9
LA358_01775	COG0463	Glycosyl transferase, family 2
LA358_01780	COG0859	PFAM glycosyl transferase family 9
LA358_01785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LA358_01790	COG2990	Protein conserved in bacteria
LA358_01795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LA358_01805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LA358_01810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LA358_01815	COG2003	Belongs to the UPF0758 family
LA358_01820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA358_01825	COG0756	dUTP diphosphatase activity
LA358_01830	COG1309	transcriptional regulator
LA358_01850	COG0668	transmembrane transport
LA358_01855	COG0166	Belongs to the GPI family
LA358_01860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LA358_01910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LA358_01920	COG0583	DNA-binding transcription factor activity
LA358_01935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LA358_01940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA358_01945	COG2223	nitrite transmembrane transporter activity
LA358_01950	COG3279	Response regulator of the LytR AlgR family
LA358_01955	COG3275	phosphorelay sensor kinase activity
LA358_01965	COG2081	HI0933 family
LA358_01970	COG1528	Iron-storage protein
LA358_01975	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LA358_01980	COG0589	response to stress
LA358_02020	COG3642	lipopolysaccharide core region biosynthetic process
LA358_02025	COG0859	PFAM glycosyl transferase family 9
LA358_02035	COG1758	RNA polymerase activity
LA358_02040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA358_02045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA358_02055	COG2267	carboxylic ester hydrolase activity
LA358_02060	COG0561	phosphatase activity
LA358_02090	COG2271	Major facilitator Superfamily
LA358_02095	COG0469	pyruvate kinase activity
LA358_02125	COG1309	transcriptional regulator
LA358_02130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_02135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA358_02145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LA358_02160	COG3118	belongs to the thioredoxin family
LA358_02165	COG0513	Belongs to the DEAD box helicase family
LA358_02170	COG0248	Ppx GppA phosphatase
LA358_02180	COG0742	ribosomal rna small subunit methyltransferase
LA358_02200	COG0084	hydrolase, TatD family'
LA358_02205	COG0805	protein transport
LA358_02210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LA358_02220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA358_02225	COG3165	ubiquinone biosynthetic process from chorismate
LA358_02235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LA358_02240	COG0402	S-adenosylhomocysteine deaminase activity
LA358_02245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LA358_02285	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LA358_02290	COG0848	biopolymer transport protein
LA358_02295	COG0811	peptide transport
LA358_02300	COG0811	peptide transport
LA358_02310	COG2771	luxR family
LA358_02320	COG1349	DNA-binding transcription factor activity
LA358_02325	COG0745	RESPONSE REGULATOR receiver
LA358_02330	COG2205	protein histidine kinase activity
LA358_02335	COG4452	Inner membrane protein CreD
LA358_02340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LA358_02345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LA358_02350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LA358_02355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA358_02360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LA358_02365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LA358_02370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LA358_02380	COG0356	it plays a direct role in the translocation of protons across the membrane
LA358_02390	COG1475	DNA binding
LA358_02395	COG1192	Involved in chromosome partitioning
LA358_02400	COG0357	Ribosomal RNA small subunit methyltransferase G
LA358_02405	COG0445	tRNA wobble uridine modification
LA358_02410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA358_02415	COG4774	siderophore transport
LA358_02420	COG4615	Cyclic peptide transporter
LA358_02425	COG1120	ATPase activity
LA358_02430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA358_02450	COG1280	lysine exporter protein (LysE YggA)
LA358_02455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LA358_02460	COG0706	membrane insertase activity
LA358_02465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LA358_02470	COG0594	ribonuclease P activity
LA358_02475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LA358_02480	COG1126	abc transporter atp-binding protein
LA358_02495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA358_02500	COG0592	DNA-directed DNA polymerase activity
LA358_02515	COG0071	Belongs to the small heat shock protein (HSP20) family
LA358_02520	COG0071	Belongs to the small heat shock protein (HSP20) family
LA358_02525	COG3977	Valine--pyruvate aminotransferase
LA358_02540	COG2814	Major facilitator Superfamily
LA358_02545	COG0745	RESPONSE REGULATOR receiver
LA358_02550	COG2205	protein histidine kinase activity
LA358_02575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA358_02585	COG2960	long-chain fatty acid transporting porin activity
LA358_02595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA358_02630	COG0683	leucine binding
LA358_02635	COG1609	Transcriptional regulator
LA358_02640	COG0348	domain, Protein
LA358_02645	COG0814	amino acid
LA358_02670	COG0751	glycine-tRNA ligase activity
LA358_02675	COG0752	glycyl-tRNA synthetase alpha subunit
LA358_02680	COG2818	Glycosylase
LA358_02685	COG2885	chlorophyll binding
LA358_02690	COG0251	oxidation-reduction process
LA358_02695	COG0425	Belongs to the sulfur carrier protein TusA family
LA358_02720	COG0183	Belongs to the thiolase family
LA358_02725	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA358_02725	COG1024	Enoyl-CoA hydratase
LA358_02730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA358_02735	COG0006	proline dipeptidase activity
LA358_02740	COG1739	Uncharacterized protein family UPF0029
LA358_02745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA358_02750	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LA358_02780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA358_02785	COG2166	iron-sulfur cluster assembly
LA358_02790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LA358_02805	COG3245	cytochrome
LA358_02810	COG1063	alcohol dehydrogenase
LA358_02815	COG0156	8-amino-7-oxononanoate synthase activity
LA358_02825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA358_02850	COG0110	maltose O-acetyltransferase activity
LA358_02900	COG1943	Transposase
LA358_02910	COG0210	DNA helicase
LA358_02915	COG1744	ABC transporter substrate-binding protein PnrA-like
LA358_02920	COG3845	ABC transporter
LA358_02925	COG4603	Belongs to the binding-protein-dependent transport system permease family
LA358_02930	COG1079	Belongs to the binding-protein-dependent transport system permease family
LA358_02940	COG0534	Mate efflux family protein
LA358_02945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA358_02950	COG2205	protein histidine kinase activity
LA358_02955	COG0745	RESPONSE REGULATOR receiver
LA358_02965	COG1045	serine acetyltransferase
LA358_02975	COG3074	FtsZ-dependent cytokinesis
LA358_02980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LA358_02985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA358_02985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA358_02990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA358_03025	COG1609	Transcriptional regulator
LA358_03030	COG3250	beta-galactosidase activity
LA358_03035	COG2731	YhcH YjgK YiaL family protein
LA358_03040	COG0531	amino acid
LA358_03045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA358_03050	COG0531	amino acid
LA358_03055	COG0385	Bile acid
LA358_03060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LA358_03080	COG0583	DNA-binding transcription factor activity
LA358_03085	COG1561	YicC-like family, N-terminal region
LA358_03090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LA358_03095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LA358_03105	COG0789	Transcriptional regulator
LA358_03110	COG2203	Gaf domain
LA358_03110	COG3706	GGDEF domain
LA358_03110	COG4251	negative regulation of phosphorylation
LA358_03110	COG5001	Diguanylate cyclase
LA358_03115	COG3084	Protein conserved in bacteria
LA358_03125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LA358_03130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA358_03135	COG3639	organic phosphonate transmembrane transporter activity
LA358_03140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LA358_03145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LA358_03155	COG1335	isochorismatase
LA358_03165	COG1683	Conserved Protein
LA358_03170	COG0204	Acyl-transferase
LA358_03175	COG0204	Acyl-transferase
LA358_03180	COG0606	chelatase, subunit chli
LA358_03190	COG3978	acetolactate synthase activity
LA358_03200	COG0129	dihydroxy-acid dehydratase activity
LA358_03215	COG1309	transcriptional regulator
LA358_03225	COG2391	methyltransferase activity
LA358_03230	COG1280	lysine exporter protein (LysE YggA)
LA358_03240	COG2962	Rard protein
LA358_03250	COG1012	belongs to the aldehyde dehydrogenase family
LA358_03255	COG1396	sequence-specific DNA binding
LA358_03260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA358_03270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LA358_03270	COG0519	Catalyzes the synthesis of GMP from XMP
LA358_03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA358_03310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LA358_03315	COG2204	response regulator
LA358_03320	COG3852	Histidine kinase
LA358_03330	COG0174	glutamine synthetase
LA358_03335	COG1217	gtp-binding protein TYPA
LA358_03340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA358_03345	COG0569	domain protein
LA358_03350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA358_03350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA358_03355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LA358_03360	COG0242	peptide deformylase activity
LA358_03365	COG1652	LysM domain
LA358_03370	COG0758	DNA mediated transformation
LA358_03375	COG2922	Belongs to the Smg family
LA358_03380	COG0551	DNA topoisomerase type I activity
LA358_03385	COG0009	L-threonylcarbamoyladenylate synthase
LA358_03390	COG0408	coproporphyrinogen oxidase activity
LA358_03395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LA358_03405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LA358_03415	COG3078	GTPase activator activity
LA358_03425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA358_03455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LA358_03460	COG1288	antiporter activity
LA358_03465	COG1438	arginine binding
LA358_03470	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LA358_03475	COG0540	Belongs to the ATCase OTCase family
LA358_03495	COG3040	lipid binding
LA358_03500	COG2207	Transcriptional regulator
LA358_03505	COG1979	alcohol dehydrogenase
LA358_03510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LA358_03515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LA358_03520	COG3681	Belongs to the UPF0597 family
LA358_03530	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA358_03535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA358_03540	COG0564	pseudouridine synthase activity
LA358_03550	COG0542	response to heat
LA358_03555	COG2502	aspartate--ammonia ligase
LA358_03560	COG1522	sequence-specific DNA binding
LA358_03570	COG5413	integral membrane protein
LA358_03575	COG0617	tRNA 3'-terminal CCA addition
LA358_03575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LA358_03575	COG0517	IMP dehydrogenase activity
LA358_03580	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_03595	COG2205	protein histidine kinase activity
LA358_03605	COG2204	response regulator
LA358_03650	COG0243	molybdopterin cofactor binding
LA358_03655	COG3005	denitrification pathway
LA358_03660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_03660	COG4191	Histidine kinase
LA358_03690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA358_03695	COG0569	domain protein
LA358_03700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LA358_03730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LA358_03745	COG0250	Participates in transcription elongation, termination and antitermination
LA358_03750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LA358_03755	COG0081	regulation of translation
LA358_03760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA358_03765	COG0222	ribosome binding
LA358_03770	COG0085	RNA polymerase activity
LA358_03775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LA358_03780	COG2964	Protein conserved in bacteria
LA358_03795	COG2923	Belongs to the DsrF TusC family
LA358_03800	COG2168	tRNA wobble position uridine thiolation
LA358_03805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LA358_03810	COG0049	tRNA binding
LA358_03815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA358_03820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LA358_03825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA358_03870	COG3714	YhhN family
LA358_03895	COG1301	dicarboxylic acid transport
LA358_03905	COG2095	MarC family integral membrane protein
LA358_03915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LA358_03925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LA358_03930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA358_03945	COG1770	oligopeptidase
LA358_03960	COG4221	oxidoreductase activity
LA358_03965	COG0583	DNA-binding transcription factor activity
LA358_03970	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA358_03995	COG0742	ribosomal rna small subunit methyltransferase
LA358_04000	COG0552	protein localization to endoplasmic reticulum
LA358_04005	COG2884	Cell division ATP-binding protein ftsE
LA358_04010	COG2177	Part of the ABC transporter FtsEX involved in
LA358_04020	COG0288	reversible hydration of carbon dioxide
LA358_04030	COG3314	Sporulation integral membrane protein YlbJ
LA358_04035	COG1228	amidohydrolase
LA358_04040	COG0010	Belongs to the arginase family
LA358_04045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LA358_04055	COG0387	Pfam Sodium calcium exchanger
LA358_04060	COG2200	EAL domain
LA358_04070	COG2200	EAL domain
LA358_04070	COG2199	diguanylate cyclase activity
LA358_04115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA358_04120	COG1459	type II secretion system
LA358_04130	COG2165	general secretion pathway protein
LA358_04165	COG1077	Cell shape determining protein MreB Mrl
LA358_04170	COG1792	Involved in formation and maintenance of cell shape
LA358_04175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LA358_04180	COG0424	maF-like protein
LA358_04185	COG1530	ribonuclease E activity
LA358_04190	COG3164	Protein of unknown function
LA358_04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA358_04200	COG0312	modulator of DNA gyrase
LA358_04215	COG0477	Major facilitator Superfamily
LA358_04225	COG3700	Belongs to the class B bacterial acid phosphatase family
LA358_04255	COG0523	cobalamin synthesis protein
LA358_04260	COG0477	Major facilitator Superfamily
LA358_04280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LA358_04285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LA358_04310	COG2203	Gaf domain
LA358_04310	COG2199	diguanylate cyclase activity
LA358_04330	COG0814	amino acid
LA358_04335	COG3932	Exopolysaccharide synthesis, ExoD
LA358_04345	COG1733	regulation of RNA biosynthetic process
LA358_04355	COG0004	ammonium transporteR
LA358_04360	COG3133	Outer membrane lipoprotein
LA358_04365	COG0456	acetyltransferase
LA358_04385	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LA358_04390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LA358_04405	COG0671	phosphoesterase, PA-phosphatase related
LA358_04410	COG0628	permease
LA358_04430	COG3284	Transcriptional regulator
LA358_04440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_04440	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LA358_04440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA358_04445	COG1461	Dihydroxyacetone kinase
LA358_04450	COG2376	Dihydroxyacetone kinase
LA358_04455	COG2252	PERMEase
LA358_04460	COG1278	Cold shock
LA358_04465	COG2801	Transposase and inactivated derivatives
LA358_04470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LA358_04485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA358_04495	COG3047	cAMP biosynthetic process
LA358_04500	COG0840	transmembrane signaling receptor activity
LA358_04520	COG3135	benzoate transporter
LA358_04525	COG1396	sequence-specific DNA binding
LA358_04570	COG2801	Transposase and inactivated derivatives
LA358_04585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA358_04585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LA358_04600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LA358_04605	COG0038	chloride channel
LA358_04615	COG0316	Belongs to the HesB IscA family
LA358_04620	COG1757	Na H antiporter
LA358_04660	COG0297	glycogen (starch) synthase activity
LA358_04665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA358_04670	COG2813	Specifically methylates the guanine in position
LA358_04675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA358_04685	COG1392	Phosphate transport regulator
LA358_04690	COG0306	phosphate transporter
LA358_04695	COG0460	homoserine dehydrogenase
LA358_04695	COG0527	aspartate kinase activity
LA358_04700	COG0626	cystathionine gamma-synthase activity
LA358_04710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA358_04715	COG0814	amino acid
LA358_04720	COG1218	3'(2'),5'-bisphosphate nucleotidase
LA358_04725	COG0494	nUDIX hydrolase
LA358_04730	COG1011	Hydrolase
LA358_04745	COG0110	maltose O-acetyltransferase activity
LA358_04750	COG3174	membrane
LA358_04755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA358_04765	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LA358_04770	COG4208	sulfate ABC transporter
LA358_04775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LA358_04780	COG0583	DNA-binding transcription factor activity
LA358_04785	COG3397	chitin binding
LA358_04790	COG0840	transmembrane signaling receptor activity
LA358_04820	COG0726	polysaccharide deacetylase
LA358_04820	COG1649	PFAM Uncharacterised BCR, COG1649
LA358_04825	COG1215	transferase activity, transferring glycosyl groups
LA358_04840	COG0726	polysaccharide deacetylase
LA358_04840	COG1649	PFAM Uncharacterised BCR, COG1649
LA358_04845	COG1215	transferase activity, transferring glycosyl groups
LA358_04895	COG1538	Outer membrane efflux protein
LA358_04900	COG0628	permease
LA358_04915	COG1328	CTP reductase activity
LA358_04920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA358_04935	COG1448	Aminotransferase
LA358_04950	COG1840	ABC-type Fe3 transport system, periplasmic component
LA358_04960	COG3842	ATPase activity
LA358_04965	COG2837	iron assimilation
LA358_04970	COG1438	arginine binding
LA358_04975	COG1126	abc transporter atp-binding protein
LA358_04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_04985	COG4215	(ABC) transporter
LA358_04990	COG4160	amino acid transport
LA358_04995	COG0039	L-malate dehydrogenase activity
LA358_05000	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LA358_05005	COG1017	nitric oxide dioxygenase activity
LA358_05005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA358_05015	COG4536	flavin adenine dinucleotide binding
LA358_05020	COG4137	Cytochrome C assembly protein
LA358_05025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA358_05030	COG0228	four-way junction DNA binding
LA358_05035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LA358_05040	COG0336	Belongs to the RNA methyltransferase TrmD family
LA358_05045	COG0335	large ribosomal subunit rRNA binding
LA358_05055	COG3066	DNA modification
LA358_05060	COG1051	belongs to the nudix hydrolase family
LA358_05070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LA358_05075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LA358_05100	COG0513	Belongs to the DEAD box helicase family
LA358_05115	COG3112	Uncharacterised protein family (UPF0231)
LA358_05120	COG3835	regulator
LA358_05125	COG2610	gluconate transmembrane transporter activity
LA358_05130	COG1929	Belongs to the glycerate kinase type-1 family
LA358_05145	COG0583	DNA-binding transcription factor activity
LA358_05150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA358_05160	COG1872	DUF167
LA358_05165	COG0762	integral membrane protein
LA358_05170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA358_05175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LA358_05190	COG3022	response to hydroperoxide
LA358_05210	COG0347	Belongs to the P(II) protein family
LA358_05230	COG0617	tRNA 3'-terminal CCA addition
LA358_05235	COG1194	a g-specific adenine glycosylase
LA358_05240	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LA358_05250	COG3111	PFAM Bacterial OB fold (BOF) protein
LA358_05255	COG3240	lipase activity
LA358_05265	COG3706	GGDEF domain
LA358_05270	COG0557	exoribonuclease II activity
LA358_05275	COG1204	response to ionizing radiation
LA358_05285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA358_05295	COG2153	protein acetylation
LA358_05300	COG0513	Belongs to the DEAD box helicase family
LA358_05305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LA358_05325	COG0735	belongs to the Fur family
LA358_05330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA358_05335	COG0840	transmembrane signaling receptor activity
LA358_05345	COG4166	transmembrane transport
LA358_05355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LA358_05360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LA358_05365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LA358_05385	COG1024	Enoyl-CoA hydratase
LA358_05400	COG4221	oxidoreductase activity
LA358_05405	COG0442	prolyl-tRNA aminoacylation
LA358_05410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA358_05415	COG3009	Protein conserved in bacteria
LA358_05420	COG3008	intermembrane lipid transfer
LA358_05420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA358_05425	COG2995	paraquat-inducible protein a
LA358_05435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA358_05445	COG3706	GGDEF domain
LA358_05445	COG4251	negative regulation of phosphorylation
LA358_05445	COG5001	Diguanylate cyclase
LA358_05445	COG2203	Gaf domain
LA358_05450	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LA358_05465	COG2771	luxR family
LA358_05480	COG0840	transmembrane signaling receptor activity
LA358_05485	COG0632	four-way junction helicase activity
LA358_05490	COG2255	four-way junction helicase activity
LA358_05500	COG1294	oxidase, subunit
LA358_05505	COG4890	Cyd operon protein YbgT
LA358_05510	COG3790	cyd operon protein YbgE
LA358_05515	COG0824	Thioesterase
LA358_05520	COG0811	peptide transport
LA358_05535	COG0823	Involved in the tonB-independent uptake of proteins
LA358_05540	COG2885	chlorophyll binding
LA358_05545	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LA358_05610	COG0733	neurotransmitter:sodium symporter activity
LA358_05620	COG0733	neurotransmitter:sodium symporter activity
LA358_05635	COG0561	phosphatase activity
LA358_05670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA358_05675	COG0358	DNA primase activity
LA358_05680	COG1610	YqeY-like protein
LA358_05685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LA358_05690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LA358_05695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LA358_05700	COG1027	Aspartate ammonia-lyase
LA358_05705	COG3030	protein affecting phage T7 exclusion by the F plasmid
LA358_05710	COG0534	Mate efflux family protein
LA358_05715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LA358_05720	COG0459	protein refolding
LA358_05770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LA358_05775	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LA358_05780	COG1178	ABC-type Fe3 transport system permease component
LA358_05785	COG4143	(ABC) transporter
LA358_05800	COG0066	3-isopropylmalate dehydratase activity
LA358_05805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LA358_05810	COG0473	3-isopropylmalate dehydrogenase activity
LA358_05815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LA358_05840	COG0028	Belongs to the TPP enzyme family
LA358_05845	COG0440	acetolactate synthase activity
LA358_05880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LA358_05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_05925	COG0745	RESPONSE REGULATOR receiver
LA358_05930	COG3104	oligopeptide transport
LA358_05935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA358_05940	COG1555	photosystem II stabilization
LA358_05945	COG0857	belongs to the CobB CobQ family
LA358_05945	COG0280	phosphate acetyltransferase
LA358_05950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LA358_05960	COG3013	Belongs to the UPF0304 family
LA358_05965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA358_05970	COG2716	regulation of RNA biosynthetic process
LA358_05975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA358_05980	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LA358_05985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LA358_05990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA358_06010	COG0784	Response regulator, receiver
LA358_06010	COG5002	protein histidine kinase activity
LA358_06010	COG2198	Histidine kinase
LA358_06025	COG2205	protein histidine kinase activity
LA358_06025	COG0784	Response regulator, receiver
LA358_06035	COG0250	Participates in transcription elongation, termination and antitermination
LA358_06040	COG1464	Belongs to the NlpA lipoprotein family
LA358_06045	COG2011	ABC-type metal ion transport system permease component
LA358_06080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LA358_06080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LA358_06085	COG0802	atpase or kinase
LA358_06090	COG0860	N-Acetylmuramoyl-L-alanine amidase
LA358_06095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LA358_06100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LA358_06105	COG1923	regulation of RNA biosynthetic process
LA358_06110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA358_06115	COG0330	HflC and HflK could
LA358_06120	COG0330	HflC and HflK could
LA358_06125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LA358_06130	COG0142	geranyltranstransferase activity
LA358_06135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LA358_06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LA358_06145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LA358_06150	COG3314	Sporulation integral membrane protein YlbJ
LA358_06155	COG0318	PFAM AMP-dependent synthetase and ligase
LA358_06160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA358_06165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA358_06180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LA358_06185	COG2967	ApaG domain
LA358_06190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA358_06195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LA358_06205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LA358_06215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LA358_06220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LA358_06225	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA358_06230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LA358_06235	COG1073	alpha beta
LA358_06245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LA358_06250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LA358_06260	COG4628	conserved protein (DUF2132)
LA358_06265	COG0688	phosphatidylethanolamine metabolic process
LA358_06270	COG1162	GTPase activity
LA358_06275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LA358_06315	COG1278	Cold shock
LA358_06325	COG0840	transmembrane signaling receptor activity
LA358_06330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA358_06340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA358_06345	COG4991	sh3 domain protein
LA358_06350	COG0506	proline dehydrogenase activity
LA358_06350	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LA358_06350	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LA358_06355	COG2816	NAD+ diphosphatase activity
LA358_06360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LA358_06365	COG1940	carbohydrate kinase activity
LA358_06370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA358_06375	COG0126	phosphoglycerate kinase activity
LA358_06385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA358_06415	COG0583	DNA-binding transcription factor activity
LA358_06425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LA358_06435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LA358_06440	COG1595	DNA-templated transcription, initiation
LA358_06445	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LA358_06450	COG3026	antisigma factor binding
LA358_06460	COG0481	GTPase activity
LA358_06465	COG0681	Belongs to the peptidase S26 family
LA358_06470	COG0571	ribonuclease III activity
LA358_06480	COG1381	Involved in DNA repair and RecF pathway recombination
LA358_06485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LA358_06500	COG2350	Protein conserved in bacteria
LA358_06505	COG2917	probably involved in intracellular septation
LA358_06510	COG0076	glutamate decarboxylase activity
LA358_06515	COG1272	protein, Hemolysin III
LA358_06520	COG0569	domain protein
LA358_06520	COG2985	domain, Protein
LA358_06535	COG3300	MHYT domain
LA358_06535	COG5001	Diguanylate cyclase
LA358_06540	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LA358_06565	COG1858	cytochrome C peroxidase
LA358_06575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA358_06580	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_06615	COG2986	histidine ammonia-lyase
LA358_06625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA358_06640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA358_06675	COG2313	pseudouridylate synthase activity
LA358_06680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA358_06680	COG1522	sequence-specific DNA binding
LA358_06710	COG2226	methyltransferase
LA358_06720	COG1765	OsmC-like protein
LA358_06735	COG3954	Phosphoribulokinase
LA358_06740	COG3089	Belongs to the UPF0270 family
LA358_06745	COG0429	hydrolase of the alpha beta-hydrolase fold
LA358_06750	COG0784	Response regulator, receiver
LA358_06750	COG0835	chemotaxis
LA358_06760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LA358_06765	COG1047	Peptidyl-prolyl cis-trans
LA358_06780	COG0545	Peptidyl-prolyl cis-trans isomerase
LA358_06785	COG2204	response regulator
LA358_06805	COG0737	Belongs to the 5'-nucleotidase family
LA358_06820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA358_06845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA358_06855	COG3721	Heme iron utilization protein
LA358_06860	COG0748	coenzyme F420 binding
LA358_06885	COG2814	Major facilitator Superfamily
LA358_06890	COG2205	protein histidine kinase activity
LA358_06935	COG0835	chemotaxis
LA358_06935	COG0784	Response regulator, receiver
LA358_06940	COG2755	lipolytic protein G-D-S-L family
LA358_06945	COG4181	ATPase activity
LA358_06950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LA358_06955	COG1090	epimerase
LA358_06960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA358_06965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LA358_06970	COG3171	Protein conserved in bacteria
LA358_06975	COG2066	Belongs to the glutaminase family
LA358_06980	COG2897	thiosulfate sulfurtransferase activity
LA358_06985	COG1404	Belongs to the peptidase S8 family
LA358_07000	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA358_07010	COG2966	Psort location CytoplasmicMembrane, score
LA358_07025	COG4175	Glycine betaine
LA358_07030	COG4176	ABC-type proline glycine betaine transport system permease component
LA358_07035	COG2113	Glycine betaine
LA358_07040	COG0175	sulfate reduction
LA358_07045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA358_07050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA358_07060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LA358_07075	COG0786	glutamate:sodium symporter activity
LA358_07080	COG0252	asparaginase activity
LA358_07085	COG3139	Protein of unknown function (DUF1315)
LA358_07105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LA358_07110	COG0321	lipoyl(octanoyl) transferase activity
LA358_07115	COG2921	Belongs to the UPF0250 family
LA358_07120	COG1686	Belongs to the peptidase S11 family
LA358_07125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LA358_07130	COG2951	lytic endotransglycosylase activity
LA358_07140	COG0768	penicillin binding
LA358_07145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LA358_07150	COG0799	negative regulation of ribosome biogenesis
LA358_07155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LA358_07170	COG0495	leucyl-tRNA aminoacylation
LA358_07175	COG2888	peptidyl-tyrosine sulfation
LA358_07185	COG0312	modulator of DNA gyrase
LA358_07195	COG4974	Belongs to the 'phage' integrase family
LA358_07205	COG1970	mechanosensitive ion channel activity
LA358_07220	COG0789	Transcriptional regulator
LA358_07230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LA358_07235	COG4535	Mg2 and Co2 transporter CorC
LA358_07240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LA358_07245	COG1702	phosphate starvation-inducible protein PhoH
LA358_07250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LA358_07255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA358_07275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA358_07280	COG2199	diguanylate cyclase activity
LA358_07295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA358_07305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LA358_07315	COG0516	GMP reductase activity
LA358_07320	COG0189	ligase activity
LA358_07320	COG4067	protein conserved in archaea
LA358_07325	COG0642	Histidine kinase
LA358_07340	COG0300	oxidoreductase activity
LA358_07365	COG3214	Protein conserved in bacteria
LA358_07375	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA358_07380	COG0700	Nucleoside recognition
LA358_07385	COG3366	ferrous iron transmembrane transporter activity
LA358_07395	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LA358_07400	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LA358_07405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA358_07410	COG1053	succinate dehydrogenase
LA358_07420	COG0584	glycerophosphoryl diester phosphodiesterase
LA358_07425	COG3264	Mechanosensitive ion channel
LA358_07425	COG1511	domain protein
LA358_07435	COG0739	heme binding
LA358_07445	COG0583	DNA-binding transcription factor activity
LA358_07465	COG0583	DNA-binding transcription factor activity
LA358_07470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LA358_07500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LA358_07505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LA358_07515	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LA358_07520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA358_07530	COG0180	Tryptophanyl-tRNA synthetase
LA358_07545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LA358_07555	COG1012	belongs to the aldehyde dehydrogenase family
LA358_07570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA358_07585	COG0488	(ABC) transporter
LA358_07595	COG0443	Heat shock 70 kDa protein
LA358_07600	COG2214	Heat shock protein DnaJ domain protein
LA358_07625	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LA358_07635	COG0471	metal ion transport
LA358_07635	COG0490	domain, Protein
LA358_07680	COG0012	GTP binding
LA358_07685	COG0193	aminoacyl-tRNA hydrolase activity
LA358_07690	COG0737	Belongs to the 5'-nucleotidase family
LA358_07695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA358_07705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LA358_07710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LA358_07715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LA358_07720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LA358_07725	COG2890	protein-(glutamine-N5) methyltransferase activity
LA358_07735	COG2912	Transglutaminase-like superfamily
LA358_07750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LA358_07760	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LA358_07760	COG3408	Glycogen debranching enzyme
LA358_07770	COG1881	PFAM PEBP family protein
LA358_07775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LA358_07790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LA358_07800	COG0583	DNA-binding transcription factor activity
LA358_07805	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_07810	COG0616	signal peptide processing
LA358_07815	COG2211	Major facilitator Superfamily
LA358_07820	COG3706	GGDEF domain
LA358_07825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LA358_07840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA358_07845	COG0826	peptidase U32
LA358_07870	COG3724	N-succinylarginine dihydrolase activity
LA358_07890	COG0840	transmembrane signaling receptor activity
LA358_07900	COG2971	BadF BadG BcrA BcrD
LA358_07910	COG4608	Belongs to the ABC transporter superfamily
LA358_07915	COG0444	Belongs to the ABC transporter superfamily
LA358_07920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA358_07925	COG0601	transmembrane transport
LA358_07935	COG2205	protein histidine kinase activity
LA358_07935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_07935	COG0784	Response regulator, receiver
LA358_07935	COG2198	Histidine kinase
LA358_07975	COG3220	belongs to the UPF0276 family
LA358_08010	COG1289	transmembrane transporter activity
LA358_08015	COG0303	'Molybdopterin
LA358_08020	COG0746	molybdenum cofactor guanylyltransferase activity
LA358_08030	COG4662	Binding-protein-dependent transport system inner membrane component
LA358_08040	COG2204	response regulator
LA358_08045	COG3852	Histidine kinase
LA358_08050	COG1910	domain protein
LA358_08055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LA358_08090	COG3383	formate dehydrogenase (NAD+) activity
LA358_08090	COG3383	formate dehydrogenase (NAD+) activity
LA358_08095	COG0437	4 iron, 4 sulfur cluster binding
LA358_08105	COG0281	malic enzyme
LA358_08120	COG2233	PERMEase
LA358_08135	COG0837	glucose binding
LA358_08140	COG1737	Transcriptional regulator
LA358_08145	COG0469	pyruvate kinase activity
LA358_08160	COG1677	Flagellar hook-basal body complex protein FliE
LA358_08170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA358_08225	COG1684	flagellar biosynthetic protein fliR
LA358_08235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LA358_08260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LA358_08265	COG0784	Response regulator, receiver
LA358_08265	COG2198	Histidine kinase
LA358_08265	COG0643	Histidine kinase
LA358_08270	COG2201	protein-glutamate methylesterase activity
LA358_08275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA358_08280	COG1360	Flagellar Motor Protein
LA358_08285	COG1192	Involved in chromosome partitioning
LA358_08295	COG0835	chemotaxis
LA358_08305	COG4133	protoheme IX ABC transporter activity
LA358_08310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA358_08315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA358_08320	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA358_08325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LA358_08330	COG1138	Cytochrome C-type biogenesis protein
LA358_08335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA358_08360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA358_08365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA358_08365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA358_08370	COG0259	pyridoxamine-phosphate oxidase activity
LA358_08375	COG0625	glutathione transferase activity
LA358_08380	COG3153	acetyltransferase
LA358_08390	COG2850	peptidyl-arginine hydroxylation
LA358_08395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LA358_08400	COG2915	High frequency lysogenization protein hflD homolog
LA358_08405	COG0482	sulfurtransferase activity
LA358_08415	COG1187	pseudouridine synthase activity
LA358_08425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_08445	COG1288	antiporter activity
LA358_08450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_08450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_08450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_08455	COG2801	Transposase and inactivated derivatives
LA358_08480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LA358_08500	COG1342	Belongs to the UPF0251 family
LA358_08515	COG1309	transcriptional regulator
LA358_08520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_08525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA358_08535	COG1091	dTDP-4-dehydrorhamnose reductase activity
LA358_08555	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_08560	COG2244	polysaccharide biosynthetic process
LA358_08590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA358_08595	COG1091	dTDP-4-dehydrorhamnose reductase activity
LA358_08610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LA358_08620	COG2916	Histone family protein nucleoid-structuring protein H-NS
LA358_08630	COG0577	efflux transmembrane transporter activity
LA358_08630	COG1136	(ABC) transporter
LA358_08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_08645	COG0497	DNA recombination
LA358_08650	COG1486	melibiose metabolic process
LA358_08655	COG0583	DNA-binding transcription factor activity
LA358_08660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LA358_08665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LA358_08670	COG0443	Heat shock 70 kDa protein
LA358_08675	COG0484	heat shock protein binding
LA358_08680	COG1285	pathogenesis
LA358_08695	COG0640	Transcriptional regulator
LA358_08725	COG0095	Lipoate-protein ligase
LA358_08735	COG0702	epimerase
LA358_08740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA358_08745	COG1454	alcohol dehydrogenase
LA358_08785	COG1280	lysine exporter protein (LysE YggA)
LA358_08790	COG3263	regulation of cellular component size
LA358_08800	COG3263	regulation of cellular component size
LA358_08815	COG1876	peptidase activity
LA358_08820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA358_08825	COG1393	Belongs to the ArsC family
LA358_08835	COG3069	C4-dicarboxylate transmembrane transporter activity
LA358_08840	COG1473	amidohydrolase
LA358_08850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LA358_08855	COG0017	Asparaginyl-tRNA synthetase
LA358_08875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LA358_08880	COG0156	8-amino-7-oxononanoate synthase activity
LA358_08885	COG1073	alpha beta
LA358_08885	COG2226	methyltransferase
LA358_08890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LA358_08895	COG0501	Belongs to the peptidase M48B family
LA358_08900	COG3217	Mosc domain protein beta barrel domain protein
LA358_08900	COG3217	Mosc domain protein beta barrel domain protein
LA358_08900	COG0633	Ferredoxin
LA358_08900	COG0633	Ferredoxin
LA358_08910	COG0674	pyruvate-flavodoxin oxidoreductase activity
LA358_08910	COG1013	pyruvate-flavodoxin oxidoreductase activity
LA358_08910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LA358_08910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA358_08920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA358_08925	COG1607	acyl-coa hydrolase
LA358_08935	COG3021	interspecies interaction between organisms
LA358_08940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA358_08945	COG2027	D-alanyl-D-alanine carboxypeptidase
LA358_08950	COG1061	Type III restriction enzyme res subunit
LA358_08955	COG1566	PFAM secretion protein HlyD family protein
LA358_08965	COG1966	Carbon starvation protein
LA358_08970	COG3279	Response regulator of the LytR AlgR family
LA358_08975	COG3275	phosphorelay sensor kinase activity
LA358_08985	COG2194	sulfuric ester hydrolase activity
LA358_08990	COG1846	Transcriptional regulator
LA358_08990	COG1940	carbohydrate kinase activity
LA358_08995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LA358_09000	COG0363	glucosamine-6-phosphate deaminase activity
LA358_09005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_09005	COG1263	PTS System
LA358_09005	COG2190	(PTS) system
LA358_09015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA358_09020	COG0735	belongs to the Fur family
LA358_09030	COG0716	FMN binding
LA358_09045	COG0596	Alpha beta hydrolase
LA358_09050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LA358_09055	COG0033	Phosphoglucomutase
LA358_09070	COG2951	lytic endotransglycosylase activity
LA358_09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA358_09080	COG4136	ATPase activity
LA358_09085	COG4135	transport system, permease component
LA358_09090	COG4134	Bacterial extracellular solute-binding protein
LA358_09095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA358_09100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA358_09115	COG0583	DNA-binding transcription factor activity
LA358_09120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA358_09130	COG0729	surface antigen
LA358_09135	COG2911	Protein conserved in bacteria
LA358_09155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LA358_09175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA358_09180	COG4771	TonB-dependent receptor
LA358_09185	COG1169	isochorismate synthase
LA358_09190	COG1021	2,3-dihydroxybenzoate-AMP ligase
LA358_09195	COG3433	isochorismatase activity
LA358_09195	COG1535	isochorismatase
LA358_09200	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_09205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA358_09205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LA358_09230	COG1278	Cold shock
LA358_09255	COG4166	transmembrane transport
LA358_09265	COG1349	DNA-binding transcription factor activity
LA358_09270	COG1882	Formate acetyltransferase
LA358_09275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA358_09280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA358_09290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA358_09305	COG4166	transmembrane transport
LA358_09310	COG0622	Phosphoesterase
LA358_09325	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LA358_09330	COG0835	chemotaxis
LA358_09330	COG0784	Response regulator, receiver
LA358_09335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LA358_09340	COG1815	bacterial-type flagellum-dependent cell motility
LA358_09355	COG1749	Flagellar hook protein flgE
LA358_09360	COG4787	bacterial-type flagellum-dependent cell motility
LA358_09370	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LA358_09375	COG1706	bacterial-type flagellum-dependent cell motility
LA358_09380	COG1705	Flagellar rod assembly protein muramidase FlgJ
LA358_09380	COG3951	Flagellar rod assembly protein muramidase FlgJ
LA358_09395	COG2239	Acts as a magnesium transporter
LA358_09405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LA358_09410	COG2716	regulation of RNA biosynthetic process
LA358_09435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA358_09440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA358_09445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LA358_09450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LA358_09470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LA358_09485	COG0590	tRNA wobble adenosine to inosine editing
LA358_09490	COG0573	inorganic phosphate transmembrane transporter activity
LA358_09495	COG0581	inorganic phosphate transmembrane transporter activity
LA358_09505	COG0704	Plays a role in the regulation of phosphate uptake
LA358_09510	COG1253	flavin adenine dinucleotide binding
LA358_09535	COG0765	amino acid transport
LA358_09540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_09545	COG2271	Major facilitator Superfamily
LA358_09555	COG2197	response regulator
LA358_09560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA358_09585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA358_09590	COG0477	Major facilitator Superfamily
LA358_09595	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA358_09605	COG1199	ATP-dependent helicase activity
LA358_09615	COG0287	Prephenate dehydrogenase
LA358_09615	COG1605	Chorismate mutase
LA358_09620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA358_09630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA358_09635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA358_09670	COG0537	adenosine 5'-monophosphoramidase activity
LA358_09690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LA358_09705	COG1301	dicarboxylic acid transport
LA358_09710	COG1733	regulation of RNA biosynthetic process
LA358_09725	COG2354	Protein conserved in bacteria
LA358_09735	COG2233	PERMEase
LA358_09745	COG1252	NADH dehydrogenase
LA358_09765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA358_09770	COG3300	MHYT domain
LA358_09770	COG5001	Diguanylate cyclase
LA358_09775	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA358_09785	COG2373	Large extracellular alpha-helical protein
LA358_09790	COG4953	penicillin-binding protein 1C
LA358_09860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA358_09885	COG0301	tRNA thio-modification
LA358_09885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA358_09900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA358_09910	COG1334	flagellar protein FlaG
LA358_09945	COG2089	acid synthase
LA358_09955	COG1083	cytidylyl-transferase
LA358_09975	COG0318	PFAM AMP-dependent synthetase and ligase
LA358_09990	COG1216	Glycosyl transferase, family 2
LA358_09995	COG0562	UDP-galactopyranose mutase
LA358_10030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA358_10035	COG1086	Polysaccharide biosynthesis protein
LA358_10040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA358_10050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA358_10075	COG0625	glutathione transferase activity
LA358_10080	COG2814	Major facilitator Superfamily
LA358_10085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA358_10095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA358_10100	COG0215	cysteine-tRNA ligase activity
LA358_10120	COG0419	ATPase involved in DNA repair
LA358_10175	COG2119	membrane
LA358_10180	COG0023	Translation Initiation Factor
LA358_10190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LA358_10205	COG0513	Belongs to the DEAD box helicase family
LA358_10210	COG0493	'glutamate synthase
LA358_10215	COG0070	glutamate synthase
LA358_10215	COG0069	glutamate synthase activity
LA358_10215	COG0067	glutamate synthase
LA358_10220	COG1242	4 iron, 4 sulfur cluster binding
LA358_10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA358_10285	COG3634	alkyl hydroperoxide reductase activity
LA358_10295	COG0517	IMP dehydrogenase activity
LA358_10300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LA358_10305	COG0343	queuine tRNA-ribosyltransferase activity
LA358_10310	COG1862	Preprotein translocase
LA358_10315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA358_10320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA358_10335	COG0826	peptidase U32
LA358_10340	COG0826	peptidase U32
LA358_10345	COG3154	lipid carrier protein
LA358_10360	COG1959	2 iron, 2 sulfur cluster binding
LA358_10365	COG1104	cysteine desulfurase activity
LA358_10370	COG0822	iron-sulfur transferase activity
LA358_10380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LA358_10385	COG0443	Heat shock 70 kDa protein
LA358_10390	COG0633	Ferredoxin
LA358_10400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LA358_10405	COG0105	UTP biosynthetic process
LA358_10410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LA358_10420	COG1426	Protein conserved in bacteria
LA358_10425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LA358_10430	COG0124	histidyl-tRNA synthetase
LA358_10435	COG2976	Protein conserved in bacteria
LA358_10440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA358_10445	COG1160	GTP binding
LA358_10450	COG1645	bacterial-type flagellum-dependent swarming motility
LA358_10455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LA358_10460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LA358_10460	COG0047	phosphoribosylformylglycinamidine synthase activity
LA358_10465	COG2056	Na+-H+ antiporter family
LA358_10470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA358_10475	COG0671	phosphoesterase, PA-phosphatase related
LA358_10480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA358_10485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA358_10495	COG0101	tRNA pseudouridine synthase activity
LA358_10500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LA358_10505	COG0285	dihydrofolate synthase activity
LA358_10510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LA358_10515	COG0393	Putative heavy-metal-binding
LA358_10520	COG1368	sulfuric ester hydrolase activity
LA358_10530	COG0527	aspartate kinase activity
LA358_10535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LA358_10535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA358_10540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA358_10560	COG0596	Alpha beta hydrolase
LA358_10565	COG0346	lactoylglutathione lyase activity
LA358_10575	COG0583	DNA-binding transcription factor activity
LA358_10580	COG1620	l-lactate permease
LA358_10590	COG1139	Iron-sulfur cluster binding protein
LA358_10615	COG0577	efflux transmembrane transporter activity
LA358_10640	COG2814	Major facilitator Superfamily
LA358_10665	COG0672	)-iron permease
LA358_10690	COG0659	secondary active sulfate transmembrane transporter activity
LA358_10705	COG0583	DNA-binding transcription factor activity
LA358_10710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA358_10715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LA358_10720	COG0539	negative regulation of cytoplasmic translation
LA358_10725	COG0776	regulation of translation
LA358_10735	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA358_10755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LA358_10760	COG0602	queuosine metabolic process
LA358_10765	COG3530	Putative quorum-sensing-regulated virulence factor
LA358_10770	COG2096	Adenosyltransferase
LA358_10775	COG2916	Histone family protein nucleoid-structuring protein H-NS
LA358_10780	COG1757	Na H antiporter
LA358_10785	COG1435	thymidine kinase activity
LA358_10805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA358_10810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LA358_10815	COG0326	Molecular chaperone. Has ATPase activity
LA358_10820	COG4172	Belongs to the ABC transporter superfamily
LA358_10825	COG4172	Belongs to the ABC transporter superfamily
LA358_10830	COG4171	peptide transport system, permease
LA358_10835	COG4168	peptide transport system, permease
LA358_10840	COG0747	negative chemotaxis
LA358_10845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LA358_10850	COG1842	Phage shock protein A
LA358_10865	COG3106	COG3106 Predicted ATPase
LA358_10870	COG3768	UPF0283 membrane protein
LA358_10875	COG0583	DNA-binding transcription factor activity
LA358_10880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LA358_10885	COG3842	ATPase activity
LA358_10890	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA358_10895	COG1177	transmembrane transport
LA358_10900	COG1012	belongs to the aldehyde dehydrogenase family
LA358_10925	COG2199	diguanylate cyclase activity
LA358_10930	COG2885	chlorophyll binding
LA358_10935	COG0861	Integral membrane protein TerC family
LA358_10950	COG1022	Amp-dependent synthetase and ligase
LA358_10975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LA358_10980	COG1278	Cold shock
LA358_10985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LA358_10990	COG0542	response to heat
LA358_10995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LA358_11000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LA358_11005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LA358_11010	COG3134	Outer membrane lipoprotein
LA358_11015	COG3706	GGDEF domain
LA358_11020	COG0492	ferredoxin-NADP+ reductase activity
LA358_11035	COG1674	ftsk spoiiie
LA358_11035	COG0531	amino acid
LA358_11040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LA358_11045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA358_11050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LA358_11055	COG1286	toxin biosynthetic process
LA358_11060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LA358_11070	COG0563	adenylate kinase activity
LA358_11075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LA358_11085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA358_11090	COG0840	transmembrane signaling receptor activity
LA358_11105	COG5001	Diguanylate cyclase
LA358_11105	COG3300	MHYT domain
LA358_11155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LA358_11160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LA358_11165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA358_11180	COG0513	Belongs to the DEAD box helicase family
LA358_11185	COG0386	Belongs to the glutathione peroxidase family
LA358_11195	COG1181	Belongs to the D-alanine--D-alanine ligase family
LA358_11205	COG2200	EAL domain
LA358_11210	COG0517	IMP dehydrogenase activity
LA358_11210	COG0516	GMP reductase activity
LA358_11215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LA358_11215	COG0519	Catalyzes the synthesis of GMP from XMP
LA358_11235	COG0500	methyltransferase
LA358_11245	COG2062	phosphohistidine phosphatase, SixA
LA358_11255	COG0697	spore germination
LA358_11265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LA358_11270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA358_11280	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA358_11285	COG1136	(ABC) transporter
LA358_11290	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA358_11295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LA358_11305	COG0544	peptidyl-prolyl cis-trans isomerase activity
LA358_11310	COG0740	serine-type endopeptidase activity
LA358_11315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LA358_11320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LA358_11325	COG0776	regulation of translation
LA358_11330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA358_11335	COG0488	(ABC) transporter
LA358_11345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA358_11350	COG3162	membrane
LA358_11365	COG1024	Enoyl-CoA hydratase
LA358_11370	COG1115	amino acid carrier protein
LA358_11380	COG3228	Belongs to the MtfA family
LA358_11385	COG1584	GPR1 FUN34 yaaH family protein
LA358_11415	COG1024	Enoyl-CoA hydratase
LA358_11420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LA358_11425	COG1960	acyl-CoA dehydrogenase activity
LA358_11430	COG1960	acyl-CoA dehydrogenase activity
LA358_11435	COG1024	Enoyl-CoA hydratase
LA358_11440	COG1024	Enoyl-CoA hydratase
LA358_11450	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_11460	COG0730	response to heat
LA358_11470	COG0582	viral genome integration into host DNA
LA358_11485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LA358_11515	COG2003	Belongs to the UPF0758 family
LA358_11530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA358_11565	COG1073	alpha beta
LA358_11570	COG0823	Involved in the tonB-independent uptake of proteins
LA358_11570	COG1506	peptidase
LA358_11575	COG0702	epimerase
LA358_11580	COG0583	DNA-binding transcription factor activity
LA358_11585	COG0667	Aldo Keto reductase
LA358_11595	COG0784	Response regulator, receiver
LA358_11595	COG2205	protein histidine kinase activity
LA358_11635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA358_11645	COG0438	transferase activity, transferring glycosyl groups
LA358_11720	COG0438	transferase activity, transferring glycosyl groups
LA358_11725	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LA358_11730	COG0437	4 iron, 4 sulfur cluster binding
LA358_11735	COG5557	Pfam Polysulphide reductase, NrfD
LA358_11740	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LA358_11745	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LA358_11750	COG1773	rubredoxin
LA358_11755	COG0747	negative chemotaxis
LA358_11765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA358_11775	COG1124	(ABC) transporter
LA358_11780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LA358_11790	COG0375	protein maturation
LA358_11795	COG0309	Hydrogenase expression formation protein (HypE)
LA358_11805	COG0298	carbon dioxide binding
LA358_11810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LA358_11820	COG1921	L-seryl-tRNASec selenium transferase activity
LA358_11830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LA358_11840	COG3260	NADH ubiquinone oxidoreductase 20
LA358_11845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_11850	COG3261	NADH dehydrogenase
LA358_11850	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LA358_11855	COG0650	Formate hydrogenlyase subunit 4
LA358_11860	COG0651	ATP synthesis coupled electron transport
LA358_11865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA358_11880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA358_11905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA358_11910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA358_11915	COG0295	cytidine deaminase activity
LA358_11920	COG1346	cytolysis
LA358_11925	COG1380	Effector of murein hydrolase LrgA
LA358_11930	COG3345	alpha-galactosidase
LA358_11940	COG2925	Exonuclease
LA358_11995	COG0617	tRNA 3'-terminal CCA addition
LA358_11995	COG0517	IMP dehydrogenase activity
LA358_11995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LA358_12000	COG1643	Atp-dependent helicase
LA358_12010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LA358_12025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LA358_12030	COG2067	long-chain fatty acid transport protein
LA358_12035	COG2067	long-chain fatty acid transport protein
LA358_12045	COG1595	DNA-templated transcription, initiation
LA358_12055	COG2304	oxidoreductase activity
LA358_12075	COG0714	Associated with various cellular activities
LA358_12080	COG0183	Belongs to the thiolase family
LA358_12085	COG1024	Enoyl-CoA hydratase
LA358_12085	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA358_12090	COG2719	SpoVR family
LA358_12095	COG2718	Belongs to the UPF0229 family
LA358_12100	COG2766	serine protein kinase
LA358_12105	COG0514	ATP-dependent DNA helicase (RecQ)
LA358_12110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LA358_12115	COG0814	amino acid
LA358_12120	COG0494	nUDIX hydrolase
LA358_12135	COG0140	phosphoribosyl-ATP diphosphatase activity
LA358_12135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LA358_12140	COG0107	imidazoleglycerol-phosphate synthase activity
LA358_12145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LA358_12150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LA358_12155	COG0131	Imidazoleglycerol-phosphate dehydratase
LA358_12155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA358_12160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LA358_12165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LA358_12170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LA358_12180	COG1199	ATP-dependent helicase activity
LA358_12185	COG1214	PFAM Peptidase M22, glycoprotease
LA358_12195	COG2267	carboxylic ester hydrolase activity
LA358_12200	COG0318	PFAM AMP-dependent synthetase and ligase
LA358_12210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA358_12215	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LA358_12220	COG0709	Synthesizes selenophosphate from selenide and ATP
LA358_12235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LA358_12240	COG0840	transmembrane signaling receptor activity
LA358_12245	COG1254	Belongs to the acylphosphatase family
LA358_12250	COG0625	glutathione transferase activity
LA358_12255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA358_12255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA358_12260	COG0489	protein tyrosine kinase activity
LA358_12265	COG0572	uridine kinase
LA358_12270	COG0717	Belongs to the dCTP deaminase family
LA358_12275	COG0306	phosphate transporter
LA358_12280	COG1530	ribonuclease E activity
LA358_12290	COG0424	maF-like protein
LA358_12295	COG1399	metal-binding, possibly nucleic acid-binding protein
LA358_12300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LA358_12305	COG0416	fatty acid biosynthetic process
LA358_12310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA358_12320	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_12325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA358_12335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA358_12340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA358_12345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LA358_12350	COG0470	DNA polymerase III
LA358_12355	COG0084	hydrolase, TatD family'
LA358_12370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA358_12370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LA358_12375	COG3008	intermembrane lipid transfer
LA358_12380	COG2995	paraquat-inducible protein a
LA358_12390	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LA358_12395	COG0372	Belongs to the citrate synthase family
LA358_12440	COG4221	oxidoreductase activity
LA358_12450	COG3141	response to X-ray
LA358_12475	COG4128	Pfam Zonular occludens toxin
LA358_12520	COG1067	ATP-dependent peptidase activity
LA358_12525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA358_12535	COG0488	(ABC) transporter
LA358_12545	COG0116	Belongs to the methyltransferase superfamily
LA358_12545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LA358_12550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LA358_12555	COG0254	rRNA binding
LA358_12575	COG0840	transmembrane signaling receptor activity
LA358_12590	COG2201	protein-glutamate methylesterase activity
LA358_12595	COG5001	Diguanylate cyclase
LA358_12595	COG2203	Gaf domain
LA358_12595	COG4251	negative regulation of phosphorylation
LA358_12595	COG3706	GGDEF domain
LA358_12600	COG0840	transmembrane signaling receptor activity
LA358_12610	COG0167	dihydroorotate dehydrogenase activity
LA358_12615	COG2902	Dehydrogenase
LA358_12625	COG0308	aminopeptidase N
LA358_12630	COG0793	Belongs to the peptidase S41A family
LA358_12635	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LA358_12640	COG1956	GAF domain-containing protein
LA358_12650	COG3278	Belongs to the heme-copper respiratory oxidase family
LA358_12665	COG2010	Cytochrome c
LA358_12690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA358_12695	COG0589	response to stress
LA358_12700	COG0037	tRNA processing
LA358_12725	COG1177	transmembrane transport
LA358_12735	COG2194	sulfuric ester hydrolase activity
LA358_12740	COG1869	D-ribose catabolic process
LA358_12745	COG1129	ABC transporter
LA358_12750	COG1172	Belongs to the binding-protein-dependent transport system permease family
LA358_12755	COG1879	ABC-type sugar transport system periplasmic component
LA358_12760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA358_12765	COG1609	Transcriptional regulator
LA358_12770	COG3300	MHYT domain
LA358_12770	COG5001	Diguanylate cyclase
LA358_12795	COG2205	protein histidine kinase activity
LA358_12795	COG0784	Response regulator, receiver
LA358_12800	COG0776	regulation of translation
LA358_12805	COG0072	phenylalanine-tRNA ligase activity
LA358_12805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA358_12810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LA358_12815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LA358_12820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LA358_12825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LA358_12830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LA358_12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA358_12865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA358_12870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA358_12875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA358_12880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LA358_12885	COG3313	Fe-S protein
LA358_12890	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LA358_12890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_12890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_12895	COG1105	Belongs to the carbohydrate kinase PfkB family
LA358_12900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_12900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_12905	COG1609	Transcriptional regulator
LA358_12910	COG0814	amino acid
LA358_12915	COG0513	Belongs to the DEAD box helicase family
LA358_12920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LA358_12925	COG2890	protein-(glutamine-N5) methyltransferase activity
LA358_12930	COG2840	Smr protein MutS2
LA358_12955	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LA358_12970	COG2824	Alkylphosphonate utilization operon protein PhnA
LA358_12975	COG3706	GGDEF domain
LA358_12980	COG0318	PFAM AMP-dependent synthetase and ligase
LA358_12985	COG1288	antiporter activity
LA358_12995	COG3134	Outer membrane lipoprotein
LA358_13000	COG2080	2 iron, 2 sulfur cluster binding
LA358_13005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LA358_13010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LA358_13015	COG2252	PERMEase
LA358_13020	COG0402	S-adenosylhomocysteine deaminase activity
LA358_13025	COG2233	PERMEase
LA358_13030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LA358_13030	COG2080	2 iron, 2 sulfur cluster binding
LA358_13035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LA358_13040	COG0402	S-adenosylhomocysteine deaminase activity
LA358_13045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA358_13045	COG0493	'glutamate synthase
LA358_13050	COG2068	MobA-Related Protein
LA358_13055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA358_13060	COG3608	succinylglutamate desuccinylase aspartoacylase
LA358_13060	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LA358_13070	COG0697	spore germination
LA358_13075	COG0549	Belongs to the carbamate kinase family
LA358_13085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA358_13090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA358_13095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LA358_13130	COG0456	acetyltransferase
LA358_13140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LA358_13145	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LA358_13155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA358_13160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA358_13170	COG0205	6-phosphofructokinase activity
LA358_13180	COG1301	dicarboxylic acid transport
LA358_13185	COG3123	guanosine phosphorylase activity
LA358_13190	COG1760	l-serine dehydratase
LA358_13195	COG1760	l-serine dehydratase
LA358_13200	COG3100	YcgL domain-containing protein
LA358_13205	COG0850	regulation of cytokinetic process
LA358_13210	COG2894	cell division
LA358_13215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LA358_13220	COG3099	Belongs to the UPF0263 family
LA358_13225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA358_13265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LA358_13270	COG0697	spore germination
LA358_13275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LA358_13280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA358_13290	COG0307	riboflavin synthase, alpha
LA358_13300	COG0534	Mate efflux family protein
LA358_13330	COG3829	transcription factor binding
LA358_13340	COG4681	YaeQ
LA358_13350	COG2186	Transcriptional regulator
LA358_13355	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LA358_13360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LA358_13365	COG0586	Pfam SNARE associated Golgi protein
LA358_13375	COG0556	nucleotide-excision repair
LA358_13390	COG2985	domain, Protein
LA358_13390	COG0569	domain protein
LA358_13395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA358_13400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LA358_13400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA358_13415	COG3069	C4-dicarboxylate transmembrane transporter activity
LA358_13430	COG1451	nucleotide metabolic process
LA358_13445	COG0417	DNA replication proofreading
LA358_13460	COG1560	Kdo2-lipid A biosynthetic process
LA358_13465	COG1560	Kdo2-lipid A biosynthetic process
LA358_13480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LA358_13485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LA358_13495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LA358_13500	COG2832	Protein of unknown function (DUF454)
LA358_13505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA358_13515	COG1011	Hydrolase
LA358_13520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LA358_13570	COG3593	DNA synthesis involved in DNA repair
LA358_13585	COG0583	DNA-binding transcription factor activity
LA358_13590	COG0730	response to heat
LA358_13595	COG3148	PFAM DTW domain containing protein
LA358_13600	COG1940	carbohydrate kinase activity
LA358_13600	COG1846	Transcriptional regulator
LA358_13605	COG0840	transmembrane signaling receptor activity
LA358_13610	COG3012	SEC-C Motif Domain Protein
LA358_13615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LA358_13620	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LA358_13625	COG0247	lactate metabolic process
LA358_13640	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LA358_13645	COG0437	4 iron, 4 sulfur cluster binding
LA358_13650	COG3301	Polysulphide reductase, NrfD
LA358_13655	COG1138	Cytochrome C-type biogenesis protein
LA358_13665	COG3088	subunit of a heme lyase
LA358_13665	COG4235	cytochrome complex assembly
LA358_13670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA358_13680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LA358_13690	COG1840	ABC-type Fe3 transport system, periplasmic component
LA358_13695	COG3842	ATPase activity
LA358_13705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA358_13715	COG1446	asparaginase
LA358_13735	COG0045	succinate-CoA ligase (ADP-forming) activity
LA358_13740	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA358_13745	COG0567	Dehydrogenase, E1 component
LA358_13755	COG1053	succinate dehydrogenase
LA358_13760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LA358_13765	COG2009	succinate dehydrogenase
LA358_13790	COG1742	UPF0060 membrane protein
LA358_13815	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LA358_13830	COG2501	S4 domain
LA358_13840	COG0583	DNA-binding transcription factor activity
LA358_13850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA358_13860	COG1132	(ABC) transporter
LA358_13865	COG1132	(ABC) transporter
LA358_13875	COG3118	belongs to the thioredoxin family
LA358_13880	COG0471	metal ion transport
LA358_13885	COG0058	SHG alpha-glucan phosphorylase activity
LA358_13900	COG2983	Belongs to the UPF0260 family
LA358_13905	COG1882	Formate acetyltransferase
LA358_13910	COG2116	formate transmembrane transporter activity
LA358_13915	COG1944	ATP diphosphatase activity
LA358_13920	COG2723	6-phospho-beta-galactosidase activity
LA358_13925	COG0583	DNA-binding transcription factor activity
LA358_13930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LA358_13945	COG4774	siderophore transport
LA358_13950	COG2207	Transcriptional regulator
LA358_13950	COG3708	Transcriptional regulator
LA358_13970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA358_13975	COG3300	MHYT domain
LA358_13975	COG5001	Diguanylate cyclase
LA358_13980	COG0583	DNA-binding transcription factor activity
LA358_13985	COG3437	response regulator, receiver
LA358_14010	COG4989	oxidoreductase activity
LA358_14015	COG0724	RNA recognition motif
LA358_14025	COG1126	abc transporter atp-binding protein
LA358_14030	COG0765	amino acid transport
LA358_14040	COG4597	amino acid ABC transporter
LA358_14045	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LA358_14055	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LA358_14075	COG4974	Belongs to the 'phage' integrase family
LA358_14110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA358_14115	COG1360	Flagellar Motor Protein
LA358_14120	COG4771	TonB-dependent receptor
LA358_14125	COG1770	oligopeptidase
LA358_14145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_14150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_14155	COG0649	NAD binding
LA358_14155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_14170	COG1034	ATP synthesis coupled electron transport
LA358_14175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LA358_14180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_14185	COG0839	Belongs to the complex I subunit 6 family
LA358_14190	COG0713	ATP synthesis coupled electron transport
LA358_14200	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA358_14205	COG1007	ATP synthesis coupled electron transport
LA358_14215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA358_14220	COG2199	diguanylate cyclase activity
LA358_14220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA358_14230	COG2050	protein possibly involved in aromatic compounds catabolism
LA358_14240	COG0247	lactate metabolic process
LA358_14240	COG0277	FAD linked oxidase domain protein
LA358_14250	COG1253	flavin adenine dinucleotide binding
LA358_14255	COG1902	pentaerythritol trinitrate reductase activity
LA358_14265	COG0647	UMP catabolic process
LA358_14270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA358_14270	COG4651	solute:proton antiporter activity
LA358_14280	COG0367	asparagine synthase
LA358_14290	COG0625	glutathione transferase activity
LA358_14300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LA358_14315	COG0564	pseudouridine synthase activity
LA358_14330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_14340	COG2431	L-lysine efflux transmembrane transporter activity
LA358_14355	COG1393	Belongs to the ArsC family
LA358_14365	COG4783	chaperone-mediated protein folding
LA358_14370	COG0425	Belongs to the sulfur carrier protein TusA family
LA358_14390	COG2326	polyphosphate kinase activity
LA358_14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA358_14410	COG3842	ATPase activity
LA358_14415	COG3833	ABC-type maltose transport systems, permease component
LA358_14420	COG1175	transmembrane transport
LA358_14430	COG3081	Nucleoid-associated protein
LA358_14435	COG3082	Protein of unknown function (DUF1414)
LA358_14440	COG3083	sulfuric ester hydrolase activity
LA358_14445	COG1464	Belongs to the NlpA lipoprotein family
LA358_14470	COG0574	Belongs to the PEP-utilizing enzyme family
LA358_14470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA358_14475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LA358_14485	COG1113	amino acid transport
LA358_14495	COG3852	Histidine kinase
LA358_14510	COG3119	arylsulfatase activity
LA358_14515	COG0641	radical SAM
LA358_14525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LA358_14525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LA358_14530	COG0509	glycine decarboxylation via glycine cleavage system
LA358_14535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LA358_14540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA358_14545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA358_14550	COG3079	Belongs to the UPF0149 family
LA358_14555	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LA358_14565	COG0642	Histidine kinase
LA358_14640	COG0322	excinuclease ABC activity
LA358_14645	COG2197	response regulator
LA358_14650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LA358_14655	COG2835	tetraacyldisaccharide 4'-kinase activity
LA358_14660	COG1663	tetraacyldisaccharide 4'-kinase activity
LA358_14665	COG1132	(ABC) transporter
LA358_14670	COG2333	competence protein COMEC
LA358_14670	COG0658	competence protein
LA358_14685	COG0433	COG0433 Predicted ATPase
LA358_14690	COG1448	Aminotransferase
LA358_14700	COG0583	DNA-binding transcription factor activity
LA358_14705	COG3085	chromosome segregation
LA358_14710	COG4574	serine-type endopeptidase inhibitor activity
LA358_14715	COG0584	glycerophosphoryl diester phosphodiesterase
LA358_14725	COG1349	DNA-binding transcription factor activity
LA358_14730	COG2271	Major facilitator Superfamily
LA358_14735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA358_14740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LA358_14750	COG0583	DNA-binding transcription factor activity
LA358_14785	COG0656	L-ascorbic acid biosynthetic process
LA358_14795	COG2814	Major facilitator Superfamily
LA358_14805	COG2979	Protein of unknown function (DUF533)
LA358_14830	COG1187	pseudouridine synthase activity
LA358_14835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LA358_14870	COG4657	Part of a membrane complex involved in electron transport
LA358_14875	COG2878	Part of a membrane complex involved in electron transport
LA358_14885	COG4658	electron transport chain
LA358_14890	COG4659	FMN binding
LA358_14895	COG4660	Part of a membrane complex involved in electron transport
LA358_14900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA358_14905	COG0346	lactoylglutathione lyase activity
LA358_14935	COG3340	Belongs to the peptidase S51 family
LA358_14950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LA358_14955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA358_14960	COG0505	Belongs to the CarA family
LA358_14965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LA358_14975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA358_14980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LA358_14985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA358_14990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LA358_14995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA358_15000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LA358_15025	COG2020	methyltransferase activity
LA358_15030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA358_15035	COG0861	Integral membrane protein TerC family
LA358_15050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA358_15055	COG0601	transmembrane transport
LA358_15065	COG2095	MarC family integral membrane protein
LA358_15070	COG1012	belongs to the aldehyde dehydrogenase family
LA358_15070	COG1454	alcohol dehydrogenase
LA358_15075	COG0217	transcriptional regulatory protein
LA358_15080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LA358_15090	COG1801	Protein of unknown function DUF72
LA358_15095	COG4106	trans-aconitate 2-methyltransferase activity
LA358_15100	COG0500	methyltransferase
LA358_15120	COG0450	alkyl hydroperoxide reductase
LA358_15125	COG0583	DNA-binding transcription factor activity
LA358_15130	COG0791	NLP P60 protein
LA358_15145	COG0538	isocitrate dehydrogenase activity
LA358_15150	COG2207	Transcriptional regulator
LA358_15155	COG1482	cell wall glycoprotein biosynthetic process
LA358_15160	COG2801	Transposase and inactivated derivatives
LA358_15165	COG3537	Alpha-1,2-mannosidase
LA358_15185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA358_15200	COG4521	taurine ABC transporter
LA358_15205	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LA358_15210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA358_15215	COG2175	clavaminate synthase activity
LA358_15220	COG3152	Membrane
LA358_15250	COG1309	transcriptional regulator
LA358_15260	COG1454	alcohol dehydrogenase
LA358_15280	COG0534	Mate efflux family protein
LA358_15290	COG2841	Protein conserved in bacteria
LA358_15300	COG5001	Diguanylate cyclase
LA358_15300	COG5002	protein histidine kinase activity
LA358_15305	COG3132	Protein of unknown function, DUF480
LA358_15335	COG0708	Exodeoxyribonuclease III
LA358_15355	COG1566	PFAM secretion protein HlyD family protein
LA358_15360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA358_15375	COG1120	ATPase activity
LA358_15380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA358_15385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA358_15390	COG4771	TonB-dependent receptor
LA358_15395	COG2375	cellular response to nickel ion
LA358_15400	COG0784	Response regulator, receiver
LA358_15400	COG3437	response regulator, receiver
LA358_15410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA358_15415	COG0328	RNA-DNA hybrid ribonuclease activity
LA358_15420	COG2226	methyltransferase
LA358_15425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA358_15430	COG1388	LysM domain
LA358_15430	COG0741	lytic transglycosylase activity
LA358_15450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LA358_15460	COG1376	ErfK ybiS ycfS ynhG family protein
LA358_15460	COG1388	LysM domain
LA358_15470	COG0471	metal ion transport
LA358_15480	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LA358_15485	COG0791	NLP P60 protein
LA358_15505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA358_15510	COG0788	formyltetrahydrofolate deformylase activity
LA358_15520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA358_15535	COG0741	lytic transglycosylase activity
LA358_15535	COG1196	nuclear chromosome segregation
LA358_15535	COG0739	heme binding
LA358_15550	COG0436	Aminotransferase
LA358_15555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LA358_15555	COG3264	Mechanosensitive ion channel
LA358_15560	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LA358_15570	COG2205	protein histidine kinase activity
LA358_15575	COG0745	RESPONSE REGULATOR receiver
LA358_15585	COG3681	Belongs to the UPF0597 family
LA358_15590	COG0251	oxidation-reduction process
LA358_15595	COG0814	amino acid
LA358_15610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LA358_15615	COG1166	arginine decarboxylase activity
LA358_15620	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA358_15635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LA358_15645	COG2353	YceI-like domain
LA358_15650	COG0583	DNA-binding transcription factor activity
LA358_15660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LA358_15665	COG0840	transmembrane signaling receptor activity
LA358_15670	COG0302	gtp cyclohydrolase
LA358_15680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA358_15705	COG2267	carboxylic ester hydrolase activity
LA358_15710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LA358_15725	COG0314	molybdopterin synthase activity
LA358_15730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LA358_15735	COG0315	cyclic pyranopterin monophosphate synthase activity
LA358_15740	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA358_15745	COG3005	denitrification pathway
LA358_15755	COG0348	domain, Protein
LA358_15760	COG0437	4 iron, 4 sulfur cluster binding
LA358_15765	COG0243	molybdopterin cofactor binding
LA358_15775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA358_15780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LA358_15785	COG3850	Histidine kinase
LA358_15790	COG2197	response regulator
LA358_15820	COG0121	glutamine amidotransferase
LA358_15825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA358_15830	COG1960	acyl-CoA dehydrogenase activity
LA358_15835	COG1473	amidohydrolase
LA358_15840	COG2914	Belongs to the UPF0125 (RnfH) family
LA358_15845	COG2867	negative regulation of translational initiation
LA358_15850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LA358_15860	COG1349	DNA-binding transcription factor activity
LA358_15865	COG0738	Major facilitator superfamily
LA358_15880	COG0235	Class ii aldolase
LA358_15890	COG1454	alcohol dehydrogenase
LA358_15895	COG3383	formate dehydrogenase (NAD+) activity
LA358_15905	COG4821	SIS domain
LA358_15910	COG4821	SIS domain
LA358_15915	COG3716	PTS system mannose fructose sorbose family IID component
LA358_15920	COG3715	PTS system
LA358_15925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_15935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LA358_15940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_15945	COG2222	sugar isomerase
LA358_15955	COG1349	DNA-binding transcription factor activity
LA358_15960	COG2017	converts alpha-aldose to the beta-anomer
LA358_15965	COG0477	Major facilitator Superfamily
LA358_15965	COG2814	Major facilitator Superfamily
LA358_15970	COG0457	Tetratricopeptide repeat
LA358_15975	COG1940	carbohydrate kinase activity
LA358_15985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LA358_15995	COG1960	acyl-CoA dehydrogenase activity
LA358_16000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LA358_16005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LA358_16010	COG1263	PTS System
LA358_16010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_16015	COG1609	Transcriptional regulator
LA358_16020	COG1309	transcriptional regulator
LA358_16025	COG2130	NADP-dependent
LA358_16030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA358_16055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LA358_16060	COG0083	homoserine kinase activity
LA358_16070	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LA358_16075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LA358_16080	COG1946	Acyl-CoA thioesterase
LA358_16095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LA358_16105	COG0009	L-threonylcarbamoyladenylate synthase
LA358_16115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA358_16120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LA358_16120	COG0512	Glutamine amidotransferase of anthranilate synthase
LA358_16125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LA358_16130	COG0134	indole-3-glycerol-phosphate synthase activity
LA358_16130	COG0135	phosphoribosylanthranilate isomerase activity
LA358_16135	COG0133	tryptophan synthase activity
LA358_16140	COG0159	tryptophan synthase activity
LA358_16165	COG1988	membrane-bound metal-dependent
LA358_16190	COG1129	ABC transporter
LA358_16195	COG1172	Belongs to the binding-protein-dependent transport system permease family
LA358_16205	COG1070	Carbohydrate kinase
LA358_16210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA358_16220	COG0798	PFAM Bile acid sodium symporter
LA358_16235	COG0640	Transcriptional regulator
LA358_16250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA358_16260	COG0745	RESPONSE REGULATOR receiver
LA358_16275	COG4988	ABC transporter
LA358_16280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LA358_16300	COG1720	tRNA m6t6A37 methyltransferase activity
LA358_16305	COG3038	cytochrome b561
LA358_16325	COG2862	Uncharacterized protein family, UPF0114
LA358_16375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA358_16380	COG1396	sequence-specific DNA binding
LA358_16380	COG1917	Cupin 2, conserved barrel domain protein
LA358_16385	COG1012	belongs to the aldehyde dehydrogenase family
LA358_16395	COG0531	amino acid
LA358_16400	COG0531	amino acid
LA358_16415	COG1283	sodium-dependent phosphate transmembrane transporter activity
LA358_16420	COG1283	sodium-dependent phosphate transmembrane transporter activity
LA358_16435	COG2974	May be involved in recombination
LA358_16445	COG0420	3'-5' exonuclease activity
LA358_16455	COG3384	dioxygenase
LA358_16465	COG0469	pyruvate kinase activity
LA358_16470	COG1196	nuclear chromosome segregation
LA358_16470	COG3264	Mechanosensitive ion channel
LA358_16475	COG2190	(PTS) system
LA358_16480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA358_16485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_16490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA358_16495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA358_16510	COG3437	response regulator, receiver
LA358_16510	COG2770	Histidine kinase
LA358_16515	COG3267	Type II secretory pathway component ExeA
LA358_16515	COG3409	Peptidoglycan-binding domain 1 protein
LA358_16525	COG3031	protein transport across the cell outer membrane
LA358_16530	COG1450	Type ii and iii secretion system protein
LA358_16535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA358_16540	COG1459	type II secretion system
LA358_16545	COG2165	general secretion pathway protein
LA358_16555	COG2165	general secretion pathway protein
LA358_16560	COG4795	General secretion pathway protein
LA358_16565	COG3156	type II secretion system protein K
LA358_16575	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LA358_16590	COG1028	Short-chain dehydrogenase reductase Sdr
LA358_16600	COG1414	Transcriptional regulator
LA358_16605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA358_16610	COG0800	Aldolase
LA358_16615	COG2731	YhcH YjgK YiaL family protein
LA358_16635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA358_16640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA358_16645	COG2723	6-phospho-beta-galactosidase activity
LA358_16650	COG1447	Phosphotransferase system cellobiose-specific component IIA
LA358_16655	COG1917	Cupin 2, conserved barrel domain protein
LA358_16655	COG2169	Transcriptional regulator
LA358_16660	COG1486	melibiose metabolic process
LA358_16680	COG0670	Belongs to the BI1 family
LA358_16685	COG1289	transmembrane transporter activity
LA358_16690	COG2920	part of a sulfur-relay system
LA358_16700	COG0673	inositol 2-dehydrogenase activity
LA358_16730	COG1032	radical SAM domain protein
LA358_16735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA358_16740	COG1566	PFAM secretion protein HlyD family protein
LA358_16750	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA358_16755	COG0733	neurotransmitter:sodium symporter activity
LA358_16785	COG0281	malic enzyme
LA358_16795	COG0534	Mate efflux family protein
LA358_16805	COG3706	GGDEF domain
LA358_16810	COG2233	PERMEase
LA358_16815	COG0095	Lipoate-protein ligase
LA358_16820	COG1115	amino acid carrier protein
LA358_16825	COG0019	diaminopimelate decarboxylase activity
LA358_16835	COG0678	peroxiredoxin activity
LA358_16845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LA358_16860	COG0545	Peptidyl-prolyl cis-trans isomerase
LA358_16875	COG3142	Participates in the control of copper homeostasis
LA358_16900	COG5002	protein histidine kinase activity
LA358_16905	COG0745	RESPONSE REGULATOR receiver
LA358_16910	COG0346	lactoylglutathione lyase activity
LA358_16915	COG3706	GGDEF domain
LA358_16920	COG3284	Transcriptional regulator
LA358_16935	COG0697	spore germination
LA358_16945	COG3290	protein histidine kinase activity
LA358_16960	COG1566	PFAM secretion protein HlyD family protein
LA358_16985	COG0602	queuosine metabolic process
LA358_16990	COG1328	CTP reductase activity
LA358_17000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LA358_17005	COG3115	cell septum assembly
LA358_17010	COG1196	nuclear chromosome segregation
LA358_17020	COG2860	membrane
LA358_17030	COG3108	Peptidase M15
LA358_17035	COG2989	Protein conserved in bacteria
LA358_17050	COG0463	Glycosyl transferase, family 2
LA358_17065	COG0366	Alpha amylase catalytic
LA358_17100	COG3706	GGDEF domain
LA358_17110	COG3590	peptidase
LA358_17120	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LA358_17125	COG1982	Orn Lys Arg decarboxylase major
LA358_17130	COG0531	amino acid
LA358_17135	COG3710	Transcriptional regulator
LA358_17140	COG0531	amino acid
LA358_17145	COG0814	amino acid
LA358_17160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA358_17165	COG0739	heme binding
LA358_17170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LA358_17190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA358_17200	COG3091	SprT-like family
LA358_17210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA358_17215	COG0189	ligase activity
LA358_17225	COG1678	Uncharacterized ACR, COG1678
LA358_17230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA358_17240	COG0714	Associated with various cellular activities
LA358_17255	COG1115	amino acid carrier protein
LA358_17260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA358_17270	COG0825	malonyl-CoA metabolic process
LA358_17280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LA358_17285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA358_17290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA358_17295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA358_17300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA358_17315	COG0750	zinc metalloprotease
LA358_17320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LA358_17325	COG0575	Belongs to the CDS family
LA358_17330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LA358_17335	COG0233	cytoplasmic translational termination
LA358_17340	COG0528	UMP kinase activity
LA358_17345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LA358_17350	COG0052	Belongs to the universal ribosomal protein uS2 family
LA358_17355	COG0024	Methionine aminopeptidase
LA358_17365	COG2171	N-acyltransferase activity
LA358_17375	COG1263	PTS System
LA358_17375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_17390	COG0716	FMN binding
LA358_17395	COG0564	pseudouridine synthase activity
LA358_17400	COG3098	single-species biofilm formation
LA358_17425	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LA358_17435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LA358_17435	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LA358_17450	COG1611	Belongs to the LOG family
LA358_17455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA358_17460	COG0473	3-isopropylmalate dehydrogenase activity
LA358_17470	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LA358_17475	COG2363	Small membrane protein
LA358_17485	COG0583	DNA-binding transcription factor activity
LA358_17490	COG0840	transmembrane signaling receptor activity
LA358_17495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA358_17510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LA358_17515	COG1666	GTP binding
LA358_17525	COG2211	Major facilitator Superfamily
LA358_17530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA358_17540	COG2813	Specifically methylates the guanine in position
LA358_17545	COG0271	Belongs to the BolA IbaG family
LA358_17550	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA358_17555	COG1805	sodium ion transport
LA358_17560	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA358_17565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA358_17570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA358_17575	COG2871	sodium ion transport
LA358_17580	COG1477	protein flavinylation
LA358_17610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA358_17625	COG0300	oxidoreductase activity
LA358_17635	COG0415	Belongs to the DNA photolyase family
LA358_17640	COG0789	Transcriptional regulator
LA358_17645	COG3272	Protein of unknown function (DUF1722)
LA358_17675	COG0077	Prephenate dehydratase
LA358_17675	COG1605	Chorismate mutase
LA358_17715	COG0300	oxidoreductase activity
LA358_17740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LA358_17780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA358_17790	COG0826	peptidase U32
LA358_17795	COG1280	lysine exporter protein (LysE YggA)
LA358_17805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA358_17825	COG0643	Histidine kinase
LA358_17825	COG2198	Histidine kinase
LA358_17830	COG0835	chemotaxis
LA358_17835	COG0840	transmembrane signaling receptor activity
LA358_17840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LA358_17845	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LA358_17850	COG2201	protein-glutamate methylesterase activity
LA358_17855	COG1185	polyribonucleotide nucleotidyltransferase activity
LA358_17860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA358_17865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LA358_17870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LA358_17875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LA358_17880	COG0195	Participates in both transcription termination and antitermination
LA358_17885	COG0779	Required for maturation of 30S ribosomal subunits
LA358_17900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA358_17905	COG0149	triose-phosphate isomerase activity
LA358_17910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA358_17915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LA358_17925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LA358_17930	COG1534	Rna-binding protein
LA358_17945	COG1360	Flagellar Motor Protein
LA358_17945	COG1360	Flagellar Motor Protein
LA358_17950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA358_17955	COG1722	exodeoxyribonuclease VII activity
LA358_17960	COG0142	geranyltranstransferase activity
LA358_17965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LA358_17975	COG0601	transmembrane transport
LA358_17985	COG4172	Belongs to the ABC transporter superfamily
LA358_17990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA358_17995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA358_18000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA358_18020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA358_18020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA358_18025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LA358_18030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA358_18035	COG0784	Response regulator, receiver
LA358_18035	COG2198	Histidine kinase
LA358_18035	COG2205	protein histidine kinase activity
LA358_18040	COG1879	ABC-type sugar transport system periplasmic component
LA358_18050	COG0745	RESPONSE REGULATOR receiver
LA358_18055	COG3005	denitrification pathway
LA358_18065	COG3381	protein complex oligomerization
LA358_18080	COG3300	MHYT domain
LA358_18080	COG5001	Diguanylate cyclase
LA358_18085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA358_18090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LA358_18095	COG0511	ligase activity, forming carbon-carbon bonds
LA358_18100	COG0439	Biotin carboxylase
LA358_18110	COG4145	pantothenate transmembrane transporter activity
LA358_18115	COG2190	(PTS) system
LA358_18115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_18115	COG1263	PTS System
LA358_18120	COG0583	DNA-binding transcription factor activity
LA358_18125	COG0604	alcohol dehydrogenase
LA358_18130	COG2264	protein methyltransferase activity
LA358_18135	COG0778	Nitroreductase
LA358_18145	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA358_18145	COG1902	pentaerythritol trinitrate reductase activity
LA358_18150	COG0616	signal peptide processing
LA358_18160	COG4174	ABC transporter (Permease)
LA358_18165	COG4239	(ABC) transporter, permease
LA358_18175	COG0444	Belongs to the ABC transporter superfamily
LA358_18180	COG4608	Belongs to the ABC transporter superfamily
LA358_18200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LA358_18210	COG0463	Glycosyl transferase, family 2
LA358_18215	COG0741	lytic transglycosylase activity
LA358_18220	COG0488	(ABC) transporter
LA358_18230	COG2252	PERMEase
LA358_18240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LA358_18250	COG2982	Protein involved in outer membrane biogenesis
LA358_18280	COG2070	2-Nitropropane dioxygenase
LA358_18300	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LA358_18310	COG2203	Gaf domain
LA358_18310	COG2199	diguanylate cyclase activity
LA358_18315	COG0513	Belongs to the DEAD box helicase family
LA358_18340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LA358_18360	COG0154	amidase activity
LA358_18365	COG2957	Belongs to the agmatine deiminase family
LA358_18380	COG1902	pentaerythritol trinitrate reductase activity
LA358_18390	COG1388	LysM domain
LA358_18390	COG4942	peptidase
LA358_18395	COG1238	metal cluster binding
LA358_18400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LA358_18405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LA358_18410	COG0585	pseudouridine synthase activity
LA358_18420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LA358_18425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LA358_18430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA358_18440	COG0668	transmembrane transport
LA358_18450	COG2731	YhcH YjgK YiaL family protein
LA358_18460	COG2132	Multicopper oxidase
LA358_18465	COG1794	racemase activity, acting on amino acids and derivatives
LA358_18480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA358_18490	COG0517	IMP dehydrogenase activity
LA358_18490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA358_18495	COG0488	(ABC) transporter
LA358_18505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA358_18555	COG0148	phosphopyruvate hydratase activity
LA358_18560	COG0504	CTP synthase activity
LA358_18565	COG3956	TIGRFAM MazG family protein
LA358_18570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA358_18575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA358_18585	COG4807	Protein conserved in bacteria
LA358_18590	COG3023	N-Acetylmuramoyl-L-alanine amidase
LA358_18595	COG0783	Belongs to the Dps family
LA358_18600	COG1151	hydroxylamine reductase activity
LA358_18605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA358_18610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA358_18615	COG0671	phosphoesterase, PA-phosphatase related
LA358_18620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA358_18625	COG0163	prenyltransferase activity
LA358_18640	COG1131	(ABC) transporter
LA358_18645	COG0842	Transport permease protein
LA358_18660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LA358_18665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LA358_18680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA358_18685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA358_18690	COG1489	DNA binding
LA358_18695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LA358_18700	COG1643	Atp-dependent helicase
LA358_18705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA358_18710	COG0346	lactoylglutathione lyase activity
LA358_18715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LA358_18730	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LA358_18745	COG1136	(ABC) transporter
LA358_18775	COG0529	Catalyzes the synthesis of activated sulfate
LA358_18780	COG3273	potassium ion transport
LA358_18780	COG0471	metal ion transport
LA358_18785	COG2895	sulfate adenylyltransferase (ATP) activity
LA358_18790	COG0175	sulfate reduction
LA358_18795	COG1648	precorrin-2 dehydrogenase activity
LA358_18795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA358_18800	COG0330	HflC and HflK could
LA358_18805	COG1585	Membrane protein implicated in regulation of membrane protease activity
LA358_18810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LA358_18820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA358_18825	COG1640	4-alpha-glucanotransferase
LA358_18830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LA358_18850	COG0494	nUDIX hydrolase
LA358_18865	COG0138	bifunctional purine biosynthesis protein purh
LA358_18875	COG3036	rescue of stalled ribosome
LA358_18880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA358_18885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LA358_18895	COG0673	inositol 2-dehydrogenase activity
LA358_18905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA358_18910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA358_18915	COG0583	DNA-binding transcription factor activity
LA358_18920	COG0477	Major facilitator Superfamily
LA358_18925	COG0456	acetyltransferase
LA358_18930	COG0456	acetyltransferase
LA358_18950	COG5001	Diguanylate cyclase
LA358_18950	COG3300	MHYT domain
LA358_18955	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LA358_18960	COG0714	Associated with various cellular activities
LA358_18975	COG0456	acetyltransferase
LA358_18985	COG1022	Amp-dependent synthetase and ligase
LA358_18995	COG2918	glutathione biosynthetic process
LA358_19000	COG0612	Peptidase, M16
LA358_19005	COG1238	metal cluster binding
LA358_19010	COG1064	alcohol dehydrogenase
LA358_19040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA358_19045	COG0359	binds to the 23S rRNA
LA358_19050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LA358_19055	COG0360	Binds together with S18 to 16S ribosomal RNA
LA358_19060	COG1914	H( )-stimulated, divalent metal cation uptake system
LA358_19065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LA358_19070	COG0776	regulation of translation
LA358_19100	COG0560	Phosphoserine phosphatase
LA358_19110	COG5001	Diguanylate cyclase
LA358_19110	COG3447	MASE1 domain protein
LA358_19110	COG5002	protein histidine kinase activity
LA358_19115	COG0813	purine-nucleoside phosphorylase activity
LA358_19120	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LA358_19125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LA358_19130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LA358_19140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA358_19145	COG0084	hydrolase, TatD family'
LA358_19150	COG2165	general secretion pathway protein
LA358_19160	COG1854	S-ribosylhomocysteine lyase activity
LA358_19175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LA358_19175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA358_19235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LA358_19240	COG1047	Peptidyl-prolyl cis-trans
LA358_19245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LA358_19250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LA358_19255	COG0196	riboflavin kinase activity
LA358_19260	COG0728	peptidoglycan biosynthetic process
LA358_19265	COG0268	Binds directly to 16S ribosomal RNA
LA358_19270	COG0640	Transcriptional regulator
LA358_19275	COG0583	DNA-binding transcription factor activity
LA358_19285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LA358_19290	COG3068	Protein conserved in bacteria
LA358_19300	COG0739	heme binding
LA358_19320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LA358_19325	COG1121	(ABC) transporter
LA358_19330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA358_19335	COG0583	DNA-binding transcription factor activity
LA358_19340	COG0697	spore germination
LA358_19345	COG1573	uracil-dna glycosylase
LA358_19360	COG2827	Endonuclease containing a URI domain
LA358_19375	COG1842	Phage shock protein A
LA358_19380	COG0204	Acyl-transferase
LA358_19400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA358_19430	COG0814	amino acid
LA358_19475	COG2329	Antibiotic biosynthesis monooxygenase
LA358_19480	COG0187	DNA topoisomerase II activity
LA358_19485	COG1051	belongs to the nudix hydrolase family
LA358_19490	COG3150	esterase
LA358_19500	COG3151	Protein conserved in bacteria
LA358_19505	COG0494	nUDIX hydrolase
LA358_19510	COG1538	Outer membrane efflux protein
LA358_19515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA358_19515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LA358_19520	COG1560	Kdo2-lipid A biosynthetic process
LA358_19525	COG2213	PTS system mannitol-specific
LA358_19525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA358_19530	COG0246	Mannitol dehydrogenase
LA358_19535	COG3722	fumarate hydratase activity
LA358_19545	COG0484	heat shock protein binding
LA358_19565	COG1671	Belongs to the UPF0178 family
LA358_19580	COG1988	membrane-bound metal-dependent
LA358_19585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA358_19590	COG0513	Belongs to the DEAD box helicase family
LA358_19615	COG1575	Belongs to the MenA family. Type 1 subfamily
LA358_19620	COG1169	isochorismate synthase
LA358_19625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LA358_19630	COG0596	Alpha beta hydrolase
LA358_19635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LA358_19640	COG1441	menaquinone biosynthetic process
LA358_19650	COG3291	Pkd domain containing protein
LA358_19655	COG2949	membrane
LA358_19660	COG1444	tRNA N-acetyltransferase activity
LA358_19680	COG1803	Methylglyoxal synthase
LA358_19685	COG1979	alcohol dehydrogenase
LA358_19700	COG4221	oxidoreductase activity
LA358_19730	COG1368	sulfuric ester hydrolase activity
LA358_19735	COG1522	sequence-specific DNA binding
LA358_19745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LA358_19750	COG1418	mRNA catabolic process
LA358_19755	COG1546	Belongs to the CinA family
LA358_19755	COG1058	Belongs to the CinA family
LA358_19765	COG0561	phosphatase activity
LA358_19775	COG2926	Belongs to the UPF0265 family
LA358_19805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LA358_19810	COG0564	pseudouridine synthase activity
LA358_19820	COG0110	maltose O-acetyltransferase activity
LA358_19825	COG0366	Alpha amylase catalytic
LA358_19830	COG1263	PTS System
LA358_19830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA358_19850	COG0252	asparaginase activity
LA358_19855	COG1253	flavin adenine dinucleotide binding
LA358_19860	COG0586	Pfam SNARE associated Golgi protein
LA358_19865	COG1686	Belongs to the peptidase S11 family
LA358_19900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LA358_19905	COG0527	aspartate kinase activity
LA358_19910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LA358_19920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LA358_19925	COG1546	Belongs to the CinA family
LA358_19965	COG0582	viral genome integration into host DNA
LA358_19970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LA358_19980	COG1346	cytolysis
LA358_19985	COG1380	Effector of murein hydrolase LrgA
LA358_19990	COG0583	DNA-binding transcription factor activity
LA358_20000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA358_20005	COG0406	alpha-ribazole phosphatase activity
LA358_20010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LA358_20020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LA358_20025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily