locus-tag	class	description
HQ397_00005	COG0784	Response regulator, receiver
HQ397_00005	COG2198	Histidine kinase
HQ397_00005	COG5002	protein histidine kinase activity
HQ397_00040	COG1464	Belongs to the NlpA lipoprotein family
HQ397_00045	COG2011	ABC-type metal ion transport system permease component
HQ397_00065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HQ397_00070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQ397_00070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQ397_00075	COG0802	atpase or kinase
HQ397_00085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQ397_00090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQ397_00095	COG1923	regulation of RNA biosynthetic process
HQ397_00100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQ397_00105	COG0330	HflC and HflK could
HQ397_00110	COG0330	HflC and HflK could
HQ397_00115	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HQ397_00120	COG0142	geranyltranstransferase activity
HQ397_00125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQ397_00130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQ397_00135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQ397_00140	COG3314	Sporulation integral membrane protein YlbJ
HQ397_00145	COG0318	PFAM AMP-dependent synthetase and ligase
HQ397_00165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ397_00175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQ397_00180	COG2967	ApaG domain
HQ397_00185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQ397_00190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ397_00200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HQ397_00205	COG3178	'Phosphotransferase
HQ397_00210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ397_00215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ397_00220	COG2252	PERMEase
HQ397_00230	COG0488	(ABC) transporter
HQ397_00250	COG0741	lytic transglycosylase activity
HQ397_00270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HQ397_00275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ397_00280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQ397_00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ397_00315	COG3721	Heme iron utilization protein
HQ397_00320	COG0748	coenzyme F420 binding
HQ397_00340	COG4771	TonB-dependent receptor
HQ397_00345	COG2814	Major facilitator Superfamily
HQ397_00350	COG3655	Transcriptional regulator
HQ397_00375	COG3397	chitin binding
HQ397_00380	COG2226	methyltransferase
HQ397_00390	COG1765	OsmC-like protein
HQ397_00405	COG3954	Phosphoribulokinase
HQ397_00410	COG2076	Multidrug Resistance protein
HQ397_00415	COG2076	Multidrug Resistance protein
HQ397_00420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HQ397_00425	COG0726	polysaccharide deacetylase
HQ397_00430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ397_00430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ397_00435	COG0463	Glycosyl transferase, family 2
HQ397_00440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ397_00450	COG3089	Belongs to the UPF0270 family
HQ397_00455	COG2203	Gaf domain
HQ397_00455	COG3706	GGDEF domain
HQ397_00455	COG4251	negative regulation of phosphorylation
HQ397_00455	COG5001	Diguanylate cyclase
HQ397_00460	COG0429	hydrolase of the alpha beta-hydrolase fold
HQ397_00465	COG0835	chemotaxis
HQ397_00465	COG0784	Response regulator, receiver
HQ397_00475	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HQ397_00480	COG1047	Peptidyl-prolyl cis-trans
HQ397_00495	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ397_00500	COG2204	response regulator
HQ397_00520	COG0737	Belongs to the 5'-nucleotidase family
HQ397_00525	COG2200	EAL domain
HQ397_00535	COG0305	Participates in initiation and elongation during chromosome replication
HQ397_00540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ397_00545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_00550	COG0826	peptidase U32
HQ397_00555	COG2199	diguanylate cyclase activity
HQ397_00555	COG2200	EAL domain
HQ397_00555	COG2203	Gaf domain
HQ397_00580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQ397_00585	COG2201	protein-glutamate methylesterase activity
HQ397_00590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HQ397_00600	COG0840	transmembrane signaling receptor activity
HQ397_00605	COG0835	chemotaxis
HQ397_00615	COG0643	Histidine kinase
HQ397_00615	COG2198	Histidine kinase
HQ397_00630	COG0840	transmembrane signaling receptor activity
HQ397_00635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ397_00645	COG1280	lysine exporter protein (LysE YggA)
HQ397_00650	COG0826	peptidase U32
HQ397_00660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HQ397_00675	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HQ397_00700	COG0300	oxidoreductase activity
HQ397_00710	COG0840	transmembrane signaling receptor activity
HQ397_00715	COG0697	spore germination
HQ397_00745	COG0077	Prephenate dehydratase
HQ397_00745	COG1605	Chorismate mutase
HQ397_00775	COG3272	Protein of unknown function (DUF1722)
HQ397_00780	COG0789	Transcriptional regulator
HQ397_00785	COG0415	Belongs to the DNA photolyase family
HQ397_00795	COG4221	oxidoreductase activity
HQ397_00810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ397_00835	COG0783	Belongs to the Dps family
HQ397_00840	COG1151	hydroxylamine reductase activity
HQ397_00850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ397_00855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ397_00855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ397_00865	COG2831	hemolysin activation secretion protein
HQ397_00880	COG3210	domain, Protein
HQ397_00930	COG2771	luxR family
HQ397_00945	COG4104	PAAR repeat-containing protein
HQ397_00985	COG0693	protein deglycase activity
HQ397_00990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HQ397_00995	COG1666	GTP binding
HQ397_01005	COG2211	Major facilitator Superfamily
HQ397_01015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ397_01025	COG2813	Specifically methylates the guanine in position
HQ397_01030	COG0271	Belongs to the BolA IbaG family
HQ397_01035	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ397_01040	COG1805	sodium ion transport
HQ397_01045	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ397_01050	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ397_01055	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ397_01060	COG2871	sodium ion transport
HQ397_01065	COG1477	protein flavinylation
HQ397_01080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ397_01085	COG0840	transmembrane signaling receptor activity
HQ397_01090	COG0583	DNA-binding transcription factor activity
HQ397_01100	COG2363	Small membrane protein
HQ397_01105	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HQ397_01120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ397_01125	COG1611	Belongs to the LOG family
HQ397_01140	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ397_01140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ397_01150	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HQ397_01175	COG3098	single-species biofilm formation
HQ397_01180	COG0564	pseudouridine synthase activity
HQ397_01200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_01200	COG1263	PTS System
HQ397_01210	COG2171	N-acyltransferase activity
HQ397_01215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HQ397_01220	COG0024	Methionine aminopeptidase
HQ397_01225	COG0052	Belongs to the universal ribosomal protein uS2 family
HQ397_01230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQ397_01235	COG0528	UMP kinase activity
HQ397_01240	COG0233	cytoplasmic translational termination
HQ397_01245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HQ397_01250	COG0575	Belongs to the CDS family
HQ397_01255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQ397_01260	COG0750	zinc metalloprotease
HQ397_01275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ397_01280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ397_01285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ397_01290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ397_01295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQ397_01305	COG0825	malonyl-CoA metabolic process
HQ397_01320	COG0531	amino acid
HQ397_01325	COG1982	Orn Lys Arg decarboxylase major
HQ397_01330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ397_01345	COG0814	amino acid
HQ397_01360	COG0531	amino acid
HQ397_01385	COG3590	peptidase
HQ397_01395	COG3706	GGDEF domain
HQ397_01435	COG0366	Alpha amylase catalytic
HQ397_01450	COG0463	Glycosyl transferase, family 2
HQ397_01465	COG2989	Protein conserved in bacteria
HQ397_01470	COG3108	Peptidase M15
HQ397_01480	COG2860	membrane
HQ397_01495	COG3115	cell septum assembly
HQ397_01500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ397_01510	COG1328	CTP reductase activity
HQ397_01515	COG0602	queuosine metabolic process
HQ397_01545	COG1566	PFAM secretion protein HlyD family protein
HQ397_01565	COG0281	malic enzyme
HQ397_01575	COG4565	transcriptional regulatory protein
HQ397_01590	COG0697	spore germination
HQ397_01605	COG3284	Transcriptional regulator
HQ397_01610	COG1960	acyl-CoA dehydrogenase activity
HQ397_01615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQ397_01620	COG0346	lactoylglutathione lyase activity
HQ397_01625	COG0745	RESPONSE REGULATOR receiver
HQ397_01660	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ397_01665	COG1131	(ABC) transporter
HQ397_01680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_01685	COG4597	amino acid ABC transporter
HQ397_01695	COG1126	abc transporter atp-binding protein
HQ397_01705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HQ397_01715	COG0678	peroxiredoxin activity
HQ397_01725	COG0019	diaminopimelate decarboxylase activity
HQ397_01730	COG1115	amino acid carrier protein
HQ397_01735	COG0095	Lipoate-protein ligase
HQ397_01740	COG2233	PERMEase
HQ397_01755	COG0534	Mate efflux family protein
HQ397_01765	COG0281	malic enzyme
HQ397_01795	COG0733	neurotransmitter:sodium symporter activity
HQ397_01800	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ397_01810	COG1566	PFAM secretion protein HlyD family protein
HQ397_01825	COG1032	radical SAM domain protein
HQ397_01860	COG0673	inositol 2-dehydrogenase activity
HQ397_01870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQ397_01875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ397_01885	COG0366	Alpha amylase catalytic
HQ397_01915	COG0788	formyltetrahydrofolate deformylase activity
HQ397_01920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ397_01930	COG3118	belongs to the thioredoxin family
HQ397_01935	COG2091	lysine biosynthetic process via aminoadipic acid
HQ397_01940	COG0791	NLP P60 protein
HQ397_01960	COG1376	ErfK ybiS ycfS ynhG family protein
HQ397_01960	COG1388	LysM domain
HQ397_01970	COG0583	DNA-binding transcription factor activity
HQ397_01975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ397_01980	COG0243	molybdopterin cofactor binding
HQ397_02030	COG1136	(ABC) transporter
HQ397_02040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ397_02060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HQ397_02070	COG1960	acyl-CoA dehydrogenase activity
HQ397_02075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ397_02085	COG0469	pyruvate kinase activity
HQ397_02090	COG1737	Transcriptional regulator
HQ397_02125	COG1677	Flagellar hook-basal body complex protein FliE
HQ397_02135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ397_02190	COG1684	flagellar biosynthetic protein fliR
HQ397_02200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HQ397_02225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HQ397_02230	COG2198	Histidine kinase
HQ397_02230	COG0643	Histidine kinase
HQ397_02230	COG0784	Response regulator, receiver
HQ397_02240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ397_02245	COG1360	Flagellar Motor Protein
HQ397_02260	COG0835	chemotaxis
HQ397_02280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ397_02285	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ397_02290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HQ397_02295	COG1138	Cytochrome C-type biogenesis protein
HQ397_02300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ397_02305	COG4235	cytochrome complex assembly
HQ397_02305	COG3088	subunit of a heme lyase
HQ397_02325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HQ397_02330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ397_02330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ397_02345	COG0259	pyridoxamine-phosphate oxidase activity
HQ397_02350	COG0625	glutathione transferase activity
HQ397_02360	COG3153	acetyltransferase
HQ397_02370	COG2850	peptidyl-arginine hydroxylation
HQ397_02375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HQ397_02380	COG2915	High frequency lysogenization protein hflD homolog
HQ397_02385	COG0482	sulfurtransferase activity
HQ397_02405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_02405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_02405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_02420	COG5599	Phosphatase
HQ397_02425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_02425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_02425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_02455	COG0456	acetyltransferase
HQ397_02475	COG0789	Transcriptional regulator
HQ397_02485	COG1609	Transcriptional regulator
HQ397_02490	COG1263	PTS System
HQ397_02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_02495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ397_02510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_02535	COG0538	isocitrate dehydrogenase activity
HQ397_02545	COG3048	D-serine ammonia-lyase activity
HQ397_02550	COG2610	gluconate transmembrane transporter activity
HQ397_02555	COG0583	DNA-binding transcription factor activity
HQ397_02560	COG1940	carbohydrate kinase activity
HQ397_02565	COG0457	Tetratricopeptide repeat
HQ397_02570	COG2814	Major facilitator Superfamily
HQ397_02570	COG0477	Major facilitator Superfamily
HQ397_02585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQ397_02590	COG2867	negative regulation of translational initiation
HQ397_02595	COG2914	Belongs to the UPF0125 (RnfH) family
HQ397_02600	COG0702	epimerase
HQ397_02605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ397_02610	COG1454	alcohol dehydrogenase
HQ397_02620	COG0564	pseudouridine synthase activity
HQ397_02650	COG1280	lysine exporter protein (LysE YggA)
HQ397_02660	COG3263	regulation of cellular component size
HQ397_02680	COG1876	peptidase activity
HQ397_02685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ397_02690	COG1393	Belongs to the ArsC family
HQ397_02695	COG0583	DNA-binding transcription factor activity
HQ397_02705	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ397_02720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ397_02725	COG0017	Asparaginyl-tRNA synthetase
HQ397_02745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ397_02750	COG0156	8-amino-7-oxononanoate synthase activity
HQ397_02755	COG2226	methyltransferase
HQ397_02755	COG1073	alpha beta
HQ397_02760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQ397_02765	COG0501	Belongs to the peptidase M48B family
HQ397_02775	COG0633	Ferredoxin
HQ397_02775	COG3217	Mosc domain protein beta barrel domain protein
HQ397_02775	COG0633	Ferredoxin
HQ397_02775	COG3217	Mosc domain protein beta barrel domain protein
HQ397_02785	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ397_02785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ397_02785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HQ397_02785	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ397_02790	COG2366	antibiotic biosynthetic process
HQ397_02795	COG1917	Cupin 2, conserved barrel domain protein
HQ397_02795	COG2169	Transcriptional regulator
HQ397_02810	COG0534	Mate efflux family protein
HQ397_02850	COG1309	transcriptional regulator
HQ397_02865	COG0791	NLP P60 protein
HQ397_02880	COG0450	alkyl hydroperoxide reductase
HQ397_02900	COG0500	methyltransferase
HQ397_02905	COG4106	trans-aconitate 2-methyltransferase activity
HQ397_02910	COG1801	Protein of unknown function DUF72
HQ397_02915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQ397_02920	COG0217	transcriptional regulatory protein
HQ397_02925	COG2194	sulfuric ester hydrolase activity
HQ397_02930	COG1846	Transcriptional regulator
HQ397_02930	COG1940	carbohydrate kinase activity
HQ397_02935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ397_02940	COG0363	glucosamine-6-phosphate deaminase activity
HQ397_02945	COG1263	PTS System
HQ397_02945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_02945	COG2190	(PTS) system
HQ397_02960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ397_02965	COG0735	belongs to the Fur family
HQ397_02975	COG0716	FMN binding
HQ397_02990	COG0596	Alpha beta hydrolase
HQ397_02995	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HQ397_03000	COG0033	Phosphoglucomutase
HQ397_03010	COG1846	Transcriptional regulator
HQ397_03015	COG2951	lytic endotransglycosylase activity
HQ397_03020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQ397_03025	COG4136	ATPase activity
HQ397_03035	COG4134	Bacterial extracellular solute-binding protein
HQ397_03045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ397_03055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ397_03060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ397_03070	COG0729	surface antigen
HQ397_03095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HQ397_03105	COG0741	lytic transglycosylase activity
HQ397_03120	COG1607	acyl-coa hydrolase
HQ397_03130	COG3021	interspecies interaction between organisms
HQ397_03135	COG0741	lytic transglycosylase activity
HQ397_03135	COG1388	LysM domain
HQ397_03140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ397_03145	COG2226	methyltransferase
HQ397_03150	COG0328	RNA-DNA hybrid ribonuclease activity
HQ397_03170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ397_03175	COG2716	regulation of RNA biosynthetic process
HQ397_03200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQ397_03205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQ397_03210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQ397_03215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQ397_03235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQ397_03250	COG0590	tRNA wobble adenosine to inosine editing
HQ397_03255	COG0573	inorganic phosphate transmembrane transporter activity
HQ397_03260	COG0581	inorganic phosphate transmembrane transporter activity
HQ397_03265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQ397_03270	COG0704	Plays a role in the regulation of phosphate uptake
HQ397_03275	COG1253	flavin adenine dinucleotide binding
HQ397_03290	COG0531	amino acid
HQ397_03305	COG1126	abc transporter atp-binding protein
HQ397_03310	COG0765	amino acid transport
HQ397_03315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_03325	COG2271	Major facilitator Superfamily
HQ397_03340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ397_03365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HQ397_03370	COG0477	Major facilitator Superfamily
HQ397_03375	COG0123	including yeast histone deacetylase and acetoin utilization protein
HQ397_03385	COG1199	ATP-dependent helicase activity
HQ397_03400	COG1448	Aminotransferase
HQ397_03405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ397_03410	COG0303	'Molybdopterin
HQ397_03415	COG0302	gtp cyclohydrolase
HQ397_03420	COG0840	transmembrane signaling receptor activity
HQ397_03425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HQ397_03435	COG0583	DNA-binding transcription factor activity
HQ397_03465	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ397_03475	COG1166	arginine decarboxylase activity
HQ397_03500	COG0814	amino acid
HQ397_03510	COG3681	Belongs to the UPF0597 family
HQ397_03515	COG2964	Protein conserved in bacteria
HQ397_03525	COG1403	HNH endonuclease
HQ397_03535	COG0346	lactoylglutathione lyase activity
HQ397_03550	COG1187	pseudouridine synthase activity
HQ397_03560	COG2807	transmembrane transport
HQ397_03570	COG0583	DNA-binding transcription factor activity
HQ397_03575	COG2271	Major facilitator Superfamily
HQ397_03590	COG1607	acyl-coa hydrolase
HQ397_03600	COG2979	Protein of unknown function (DUF533)
HQ397_03610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ397_03615	COG1271	oxidase subunit
HQ397_03620	COG1294	oxidase, subunit
HQ397_03630	COG2814	Major facilitator Superfamily
HQ397_03635	COG0656	L-ascorbic acid biosynthetic process
HQ397_03655	COG0583	DNA-binding transcription factor activity
HQ397_03660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQ397_03665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ397_03670	COG2271	Major facilitator Superfamily
HQ397_03675	COG1349	DNA-binding transcription factor activity
HQ397_03690	COG0584	glycerophosphoryl diester phosphodiesterase
HQ397_03695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ397_03700	COG0287	Prephenate dehydrogenase
HQ397_03700	COG1605	Chorismate mutase
HQ397_03705	COG0583	DNA-binding transcription factor activity
HQ397_03710	COG3085	chromosome segregation
HQ397_03715	COG4574	serine-type endopeptidase inhibitor activity
HQ397_03735	COG1770	oligopeptidase
HQ397_03740	COG4771	TonB-dependent receptor
HQ397_03750	COG3082	Protein of unknown function (DUF1414)
HQ397_03755	COG3081	Nucleoid-associated protein
HQ397_03765	COG1175	transmembrane transport
HQ397_03770	COG3833	ABC-type maltose transport systems, permease component
HQ397_03775	COG3842	ATPase activity
HQ397_03800	COG0425	Belongs to the sulfur carrier protein TusA family
HQ397_03805	COG4783	chaperone-mediated protein folding
HQ397_03810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ397_03815	COG1393	Belongs to the ArsC family
HQ397_03830	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HQ397_03835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ397_03840	COG2431	L-lysine efflux transmembrane transporter activity
HQ397_03850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_03870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ397_03880	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ397_03890	COG4953	penicillin-binding protein 1C
HQ397_03900	COG0582	viral genome integration into host DNA
HQ397_03955	COG2974	May be involved in recombination
HQ397_03990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ397_04080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQ397_04280	COG0301	tRNA thio-modification
HQ397_04280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ397_04295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ397_04340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ397_04360	COG0483	inositol monophosphate 1-phosphatase activity
HQ397_04370	COG0625	glutathione transferase activity
HQ397_04375	COG2814	Major facilitator Superfamily
HQ397_04395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ397_04400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ397_04405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQ397_04410	COG0509	glycine decarboxylation via glycine cleavage system
HQ397_04415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ397_04415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ397_04420	COG0640	Transcriptional regulator
HQ397_04425	COG0798	PFAM Bile acid sodium symporter
HQ397_04430	COG1393	Belongs to the ArsC family
HQ397_04450	COG3634	alkyl hydroperoxide reductase activity
HQ397_04460	COG0517	IMP dehydrogenase activity
HQ397_04465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQ397_04470	COG0343	queuine tRNA-ribosyltransferase activity
HQ397_04475	COG1862	Preprotein translocase
HQ397_04485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ397_04505	COG0826	peptidase U32
HQ397_04510	COG3154	lipid carrier protein
HQ397_04530	COG1104	cysteine desulfurase activity
HQ397_04535	COG0822	iron-sulfur transferase activity
HQ397_04545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ397_04550	COG0443	Heat shock 70 kDa protein
HQ397_04555	COG0633	Ferredoxin
HQ397_04565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ397_04570	COG0105	UTP biosynthetic process
HQ397_04575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQ397_04590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HQ397_04595	COG0124	histidyl-tRNA synthetase
HQ397_04600	COG2976	Protein conserved in bacteria
HQ397_04610	COG1160	GTP binding
HQ397_04615	COG1645	bacterial-type flagellum-dependent swarming motility
HQ397_04620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ397_04625	COG0047	phosphoribosylformylglycinamidine synthase activity
HQ397_04625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQ397_04630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ397_04630	COG2199	diguanylate cyclase activity
HQ397_04645	COG1007	ATP synthesis coupled electron transport
HQ397_04650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_04660	COG0713	ATP synthesis coupled electron transport
HQ397_04665	COG0839	Belongs to the complex I subunit 6 family
HQ397_04670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_04675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ397_04680	COG1034	ATP synthesis coupled electron transport
HQ397_04695	COG0649	NAD binding
HQ397_04695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_04700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_04705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_04710	COG1360	Flagellar Motor Protein
HQ397_04715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ397_04735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HQ397_04755	COG0724	RNA recognition motif
HQ397_04760	COG4989	oxidoreductase activity
HQ397_04785	COG3437	response regulator, receiver
HQ397_04790	COG0583	DNA-binding transcription factor activity
HQ397_04800	COG3300	MHYT domain
HQ397_04800	COG5001	Diguanylate cyclase
HQ397_04805	COG0778	Nitroreductase
HQ397_04825	COG0583	DNA-binding transcription factor activity
HQ397_04835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ397_04840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQ397_04845	COG0539	negative regulation of cytoplasmic translation
HQ397_04850	COG0776	regulation of translation
HQ397_04860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HQ397_04880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HQ397_04885	COG0602	queuosine metabolic process
HQ397_04890	COG3530	Putative quorum-sensing-regulated virulence factor
HQ397_04895	COG2096	Adenosyltransferase
HQ397_04900	COG2916	Histone family protein nucleoid-structuring protein H-NS
HQ397_04905	COG1757	Na H antiporter
HQ397_04910	COG1435	thymidine kinase activity
HQ397_04945	COG3209	COG3209 Rhs family protein
HQ397_05010	COG3829	transcription factor binding
HQ397_05070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQ397_05080	COG1278	Cold shock
HQ397_05085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HQ397_05095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQ397_05100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HQ397_05105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQ397_05110	COG3134	Outer membrane lipoprotein
HQ397_05120	COG0492	ferredoxin-NADP+ reductase activity
HQ397_05125	COG0686	Belongs to the AlaDH PNT family
HQ397_05135	COG1674	ftsk spoiiie
HQ397_05135	COG0531	amino acid
HQ397_05140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HQ397_05145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HQ397_05150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQ397_05155	COG1286	toxin biosynthetic process
HQ397_05160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HQ397_05170	COG4172	Belongs to the ABC transporter superfamily
HQ397_05185	COG4168	peptide transport system, permease
HQ397_05195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HQ397_05200	COG1842	Phage shock protein A
HQ397_05215	COG3106	COG3106 Predicted ATPase
HQ397_05220	COG3768	UPF0283 membrane protein
HQ397_05230	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQ397_05250	COG2199	diguanylate cyclase activity
HQ397_05255	COG2885	chlorophyll binding
HQ397_05260	COG0861	Integral membrane protein TerC family
HQ397_05275	COG1022	Amp-dependent synthetase and ligase
HQ397_05280	COG0295	cytidine deaminase activity
HQ397_05285	COG1346	cytolysis
HQ397_05290	COG1380	Effector of murein hydrolase LrgA
HQ397_05295	COG3345	alpha-galactosidase
HQ397_05305	COG2925	Exonuclease
HQ397_05310	COG2160	L-arabinose isomerase activity
HQ397_05320	COG1069	ribulokinase activity
HQ397_05325	COG1879	ABC-type sugar transport system periplasmic component
HQ397_05335	COG1172	Belongs to the binding-protein-dependent transport system permease family
HQ397_05345	COG0583	DNA-binding transcription factor activity
HQ397_05355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ397_05360	COG0254	rRNA binding
HQ397_05375	COG1451	nucleotide metabolic process
HQ397_05400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HQ397_05400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ397_05405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ397_05430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HQ397_05435	COG1053	succinate dehydrogenase
HQ397_05445	COG0567	Dehydrogenase, E1 component
HQ397_05450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ397_05455	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ397_05460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HQ397_05470	COG2983	Belongs to the UPF0260 family
HQ397_05475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ397_05485	COG3842	ATPase activity
HQ397_05490	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ397_05500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HQ397_05505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HQ397_05510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ397_05515	COG1882	Formate acetyltransferase
HQ397_05520	COG2116	formate transmembrane transporter activity
HQ397_05525	COG1944	ATP diphosphatase activity
HQ397_05535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ397_05540	COG0612	Peptidase, M16
HQ397_05545	COG0626	cystathionine gamma-synthase activity
HQ397_05555	COG2910	NAD(P)H-binding
HQ397_05560	COG0583	DNA-binding transcription factor activity
HQ397_05570	COG4977	sequence-specific DNA binding
HQ397_05575	COG4774	siderophore transport
HQ397_05590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HQ397_05615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ397_05620	COG3046	protein related to deoxyribodipyrimidine photolyase
HQ397_05630	COG3033	Beta-eliminating lyase
HQ397_05640	COG1051	belongs to the nudix hydrolase family
HQ397_05645	COG3088	subunit of a heme lyase
HQ397_05645	COG4235	cytochrome complex assembly
HQ397_05650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ397_05655	COG1138	Cytochrome C-type biogenesis protein
HQ397_05660	COG3301	Polysulphide reductase, NrfD
HQ397_05665	COG0437	4 iron, 4 sulfur cluster binding
HQ397_05670	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HQ397_05680	COG0247	lactate metabolic process
HQ397_05685	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HQ397_05690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQ397_05695	COG3012	SEC-C Motif Domain Protein
HQ397_05700	COG0840	transmembrane signaling receptor activity
HQ397_05705	COG1846	Transcriptional regulator
HQ397_05705	COG1940	carbohydrate kinase activity
HQ397_05710	COG3290	protein histidine kinase activity
HQ397_05715	COG4565	transcriptional regulatory protein
HQ397_05735	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ397_05740	COG2985	domain, Protein
HQ397_05740	COG0569	domain protein
HQ397_05750	COG0556	nucleotide-excision repair
HQ397_05760	COG0586	Pfam SNARE associated Golgi protein
HQ397_05765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ397_05770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ397_05775	COG2186	Transcriptional regulator
HQ397_05780	COG2719	SpoVR family
HQ397_05790	COG2766	serine protein kinase
HQ397_05795	COG0514	ATP-dependent DNA helicase (RecQ)
HQ397_05800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HQ397_05805	COG0814	amino acid
HQ397_05835	COG0058	SHG alpha-glucan phosphorylase activity
HQ397_05840	COG0471	metal ion transport
HQ397_05845	COG3118	belongs to the thioredoxin family
HQ397_05855	COG1132	(ABC) transporter
HQ397_05860	COG1132	(ABC) transporter
HQ397_05875	COG2501	S4 domain
HQ397_05905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ397_05910	COG2329	Antibiotic biosynthesis monooxygenase
HQ397_05940	COG1742	UPF0060 membrane protein
HQ397_05950	COG0456	acetyltransferase
HQ397_05955	COG0513	Belongs to the DEAD box helicase family
HQ397_05960	COG0386	Belongs to the glutathione peroxidase family
HQ397_06000	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQ397_06010	COG3148	PFAM DTW domain containing protein
HQ397_06015	COG0730	response to heat
HQ397_06020	COG0583	DNA-binding transcription factor activity
HQ397_06035	COG3593	DNA synthesis involved in DNA repair
HQ397_06090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ397_06095	COG1011	Hydrolase
HQ397_06100	COG1473	amidohydrolase
HQ397_06105	COG0205	6-phosphofructokinase activity
HQ397_06115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HQ397_06120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ397_06130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HQ397_06135	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HQ397_06140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQ397_06155	COG0242	peptide deformylase activity
HQ397_06185	COG0384	phenazine biosynthesis protein PhzF
HQ397_06200	COG2824	Alkylphosphonate utilization operon protein PhnA
HQ397_06235	COG3706	GGDEF domain
HQ397_06245	COG2840	Smr protein MutS2
HQ397_06250	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ397_06255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQ397_06265	COG0513	Belongs to the DEAD box helicase family
HQ397_06270	COG5654	RES domain protein
HQ397_06285	COG0814	amino acid
HQ397_06290	COG1609	Transcriptional regulator
HQ397_06295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_06295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_06300	COG1105	Belongs to the carbohydrate kinase PfkB family
HQ397_06305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_06305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ397_06305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HQ397_06310	COG2140	Oxalate decarboxylase
HQ397_06315	COG1609	Transcriptional regulator
HQ397_06330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_06330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_06335	COG3715	PTS system
HQ397_06340	COG3716	PTS system mannose fructose sorbose family IID component
HQ397_06345	COG2942	2-epimerase
HQ397_06350	COG3313	Fe-S protein
HQ397_06355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HQ397_06360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ397_06365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ397_06370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ397_06380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ397_06405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQ397_06410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQ397_06415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQ397_06420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQ397_06425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQ397_06430	COG0072	phenylalanine-tRNA ligase activity
HQ397_06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ397_06435	COG0776	regulation of translation
HQ397_06465	COG2199	diguanylate cyclase activity
HQ397_06470	COG1609	Transcriptional regulator
HQ397_06475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ397_06480	COG1879	ABC-type sugar transport system periplasmic component
HQ397_06485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HQ397_06490	COG1129	ABC transporter
HQ397_06495	COG1869	D-ribose catabolic process
HQ397_06515	COG0037	tRNA processing
HQ397_06520	COG0589	response to stress
HQ397_06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ397_06550	COG2010	Cytochrome c
HQ397_06565	COG3278	Belongs to the heme-copper respiratory oxidase family
HQ397_06575	COG1956	GAF domain-containing protein
HQ397_06580	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HQ397_06590	COG0308	aminopeptidase N
HQ397_06600	COG2902	Dehydrogenase
HQ397_06605	COG0167	dihydroorotate dehydrogenase activity
HQ397_06615	COG0116	Belongs to the methyltransferase superfamily
HQ397_06615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ397_06625	COG0488	(ABC) transporter
HQ397_06640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ397_06645	COG1067	ATP-dependent peptidase activity
HQ397_06685	COG4128	Pfam Zonular occludens toxin
HQ397_06710	COG3141	response to X-ray
HQ397_06765	COG0372	Belongs to the citrate synthase family
HQ397_06770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HQ397_06780	COG2995	paraquat-inducible protein a
HQ397_06790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ397_06790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HQ397_06805	COG0084	hydrolase, TatD family'
HQ397_06810	COG0470	DNA polymerase III
HQ397_06815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HQ397_06820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQ397_06825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQ397_06835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ397_06840	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_06850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ397_06855	COG0416	fatty acid biosynthetic process
HQ397_06860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQ397_06865	COG1399	metal-binding, possibly nucleic acid-binding protein
HQ397_06880	COG2814	Major facilitator Superfamily
HQ397_06885	COG0424	maF-like protein
HQ397_06890	COG0546	phosphoglycolate phosphatase activity
HQ397_06895	COG0564	pseudouridine synthase activity
HQ397_06900	COG1530	ribonuclease E activity
HQ397_06905	COG0306	phosphate transporter
HQ397_06910	COG0717	Belongs to the dCTP deaminase family
HQ397_06915	COG0572	uridine kinase
HQ397_06920	COG0489	protein tyrosine kinase activity
HQ397_06925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ397_06925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ397_06930	COG0625	glutathione transferase activity
HQ397_06935	COG1254	Belongs to the acylphosphatase family
HQ397_06945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ397_06960	COG0709	Synthesizes selenophosphate from selenide and ATP
HQ397_06970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ397_06975	COG3437	response regulator, receiver
HQ397_06985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQ397_06995	COG1643	Atp-dependent helicase
HQ397_07000	COG0517	IMP dehydrogenase activity
HQ397_07000	COG0617	tRNA 3'-terminal CCA addition
HQ397_07000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQ397_07015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQ397_07025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQ397_07030	COG2832	Protein of unknown function (DUF454)
HQ397_07035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ397_07055	COG0318	PFAM AMP-dependent synthetase and ligase
HQ397_07060	COG0596	Alpha beta hydrolase
HQ397_07060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ397_07060	COG2226	methyltransferase
HQ397_07070	COG1214	PFAM Peptidase M22, glycoprotease
HQ397_07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQ397_07090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ397_07095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ397_07100	COG0131	Imidazoleglycerol-phosphate dehydratase
HQ397_07100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ397_07105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQ397_07110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQ397_07115	COG3437	response regulator, receiver
HQ397_07120	COG2199	diguanylate cyclase activity
HQ397_07125	COG0784	Response regulator, receiver
HQ397_07125	COG2205	protein histidine kinase activity
HQ397_07125	COG2198	Histidine kinase
HQ397_07130	COG0107	imidazoleglycerol-phosphate synthase activity
HQ397_07135	COG0140	phosphoribosyl-ATP diphosphatase activity
HQ397_07135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HQ397_07145	COG0318	PFAM AMP-dependent synthetase and ligase
HQ397_07150	COG1288	antiporter activity
HQ397_07170	COG2080	2 iron, 2 sulfur cluster binding
HQ397_07175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ397_07180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ397_07185	COG2252	PERMEase
HQ397_07190	COG0402	S-adenosylhomocysteine deaminase activity
HQ397_07195	COG2233	PERMEase
HQ397_07200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ397_07200	COG2080	2 iron, 2 sulfur cluster binding
HQ397_07205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ397_07210	COG0402	S-adenosylhomocysteine deaminase activity
HQ397_07215	COG0493	'glutamate synthase
HQ397_07215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_07225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ397_07230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQ397_07230	COG3608	succinylglutamate desuccinylase aspartoacylase
HQ397_07235	COG0697	spore germination
HQ397_07250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ397_07255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ397_07265	COG3829	transcription factor binding
HQ397_07310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ397_07310	COG1024	Enoyl-CoA hydratase
HQ397_07315	COG0183	Belongs to the thiolase family
HQ397_07320	COG0714	Associated with various cellular activities
HQ397_07365	COG2067	long-chain fatty acid transport protein
HQ397_07370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HQ397_07390	COG3123	guanosine phosphorylase activity
HQ397_07395	COG1760	l-serine dehydratase
HQ397_07400	COG1760	l-serine dehydratase
HQ397_07405	COG2951	lytic endotransglycosylase activity
HQ397_07410	COG3100	YcgL domain-containing protein
HQ397_07415	COG0850	regulation of cytokinetic process
HQ397_07420	COG2894	cell division
HQ397_07425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HQ397_07430	COG3099	Belongs to the UPF0263 family
HQ397_07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ397_07475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ397_07480	COG0697	spore germination
HQ397_07485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HQ397_07490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ397_07500	COG0307	riboflavin synthase, alpha
HQ397_07510	COG0534	Mate efflux family protein
HQ397_07540	COG0417	DNA replication proofreading
HQ397_07565	COG1560	Kdo2-lipid A biosynthetic process
HQ397_07570	COG1560	Kdo2-lipid A biosynthetic process
HQ397_07580	COG0583	DNA-binding transcription factor activity
HQ397_07585	COG0673	inositol 2-dehydrogenase activity
HQ397_07590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HQ397_07595	COG0583	DNA-binding transcription factor activity
HQ397_07600	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_07605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ397_07615	COG3300	MHYT domain
HQ397_07615	COG5001	Diguanylate cyclase
HQ397_07620	COG2723	6-phospho-beta-galactosidase activity
HQ397_07625	COG0583	DNA-binding transcription factor activity
HQ397_07630	COG3706	GGDEF domain
HQ397_07645	COG0667	Aldo Keto reductase
HQ397_07650	COG0583	DNA-binding transcription factor activity
HQ397_07660	COG0730	response to heat
HQ397_07670	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_07680	COG1024	Enoyl-CoA hydratase
HQ397_07690	COG1960	acyl-CoA dehydrogenase activity
HQ397_07700	COG1960	acyl-CoA dehydrogenase activity
HQ397_07740	COG1584	GPR1 FUN34 yaaH family protein
HQ397_07755	COG1115	amino acid carrier protein
HQ397_07760	COG1024	Enoyl-CoA hydratase
HQ397_07775	COG3162	membrane
HQ397_07780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ397_07785	COG0488	(ABC) transporter
HQ397_07790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ397_07795	COG0776	regulation of translation
HQ397_07800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HQ397_07805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQ397_07810	COG0740	serine-type endopeptidase activity
HQ397_07815	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQ397_07825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HQ397_07830	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ397_07835	COG1136	(ABC) transporter
HQ397_07840	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ397_07850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQ397_07855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQ397_07860	COG4166	transmembrane transport
HQ397_07865	COG0697	spore germination
HQ397_07875	COG2062	phosphohistidine phosphatase, SixA
HQ397_07925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ397_07925	COG0519	Catalyzes the synthesis of GMP from XMP
HQ397_07930	COG0517	IMP dehydrogenase activity
HQ397_07930	COG0516	GMP reductase activity
HQ397_07935	COG3158	transport of potassium into the cell
HQ397_07955	COG0697	spore germination
HQ397_07960	COG1570	exodeoxyribonuclease VII activity
HQ397_07975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ397_07980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HQ397_07985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HQ397_08025	COG4771	TonB-dependent receptor
HQ397_08030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ397_08035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ397_08040	COG1120	ATPase activity
HQ397_08050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ397_08055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ397_08065	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_08075	COG1535	isochorismatase
HQ397_08075	COG3433	isochorismatase activity
HQ397_08080	COG1021	2,3-dihydroxybenzoate-AMP ligase
HQ397_08100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ397_08105	COG3300	MHYT domain
HQ397_08105	COG5001	Diguanylate cyclase
HQ397_08120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ397_08130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ397_08135	COG0563	adenylate kinase activity
HQ397_08140	COG0326	Molecular chaperone. Has ATPase activity
HQ397_08145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQ397_08170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_08185	COG3158	transport of potassium into the cell
HQ397_08190	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_08195	COG0651	ATP synthesis coupled electron transport
HQ397_08200	COG0650	Formate hydrogenlyase subunit 4
HQ397_08205	COG3261	NADH dehydrogenase
HQ397_08205	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HQ397_08210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_08215	COG3260	NADH ubiquinone oxidoreductase 20
HQ397_08245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HQ397_08250	COG0298	carbon dioxide binding
HQ397_08260	COG0309	Hydrogenase expression formation protein (HypE)
HQ397_08265	COG0375	protein maturation
HQ397_08270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HQ397_08275	COG3842	ATPase activity
HQ397_08280	COG0444	Belongs to the ABC transporter superfamily
HQ397_08285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ397_08290	COG0601	transmembrane transport
HQ397_08300	COG1773	rubredoxin
HQ397_08305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HQ397_08310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HQ397_08315	COG5557	Pfam Polysulphide reductase, NrfD
HQ397_08320	COG0437	4 iron, 4 sulfur cluster binding
HQ397_08325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HQ397_08345	COG0840	transmembrane signaling receptor activity
HQ397_08345	COG3290	protein histidine kinase activity
HQ397_08350	COG0835	chemotaxis
HQ397_08360	COG2201	protein-glutamate methylesterase activity
HQ397_08370	COG0840	transmembrane signaling receptor activity
HQ397_08375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ397_08395	COG0659	secondary active sulfate transmembrane transporter activity
HQ397_08425	COG0672	)-iron permease
HQ397_08445	COG2814	Major facilitator Superfamily
HQ397_08455	COG1136	(ABC) transporter
HQ397_08460	COG0577	efflux transmembrane transporter activity
HQ397_08490	COG1139	Iron-sulfur cluster binding protein
HQ397_08505	COG0583	DNA-binding transcription factor activity
HQ397_08515	COG0346	lactoylglutathione lyase activity
HQ397_08520	COG0596	Alpha beta hydrolase
HQ397_08540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ397_08545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ397_08545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HQ397_08550	COG0527	aspartate kinase activity
HQ397_08560	COG1368	sulfuric ester hydrolase activity
HQ397_08565	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ397_08570	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ397_08580	COG0393	Putative heavy-metal-binding
HQ397_08600	COG1252	NADH dehydrogenase
HQ397_08605	COG3150	esterase
HQ397_08635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ397_08640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ397_08675	COG0537	adenosine 5'-monophosphoramidase activity
HQ397_08690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ397_08705	COG1301	dicarboxylic acid transport
HQ397_08715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ397_08720	COG0861	Integral membrane protein TerC family
HQ397_08740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ397_08745	COG0601	transmembrane transport
HQ397_08755	COG2095	MarC family integral membrane protein
HQ397_08765	COG1454	alcohol dehydrogenase
HQ397_08765	COG1012	belongs to the aldehyde dehydrogenase family
HQ397_08770	COG2199	diguanylate cyclase activity
HQ397_08770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ397_08775	COG3275	phosphorelay sensor kinase activity
HQ397_08780	COG3279	Response regulator of the LytR AlgR family
HQ397_08785	COG1966	Carbon starvation protein
HQ397_08795	COG1566	PFAM secretion protein HlyD family protein
HQ397_08800	COG1061	Type III restriction enzyme res subunit
HQ397_08805	COG2027	D-alanyl-D-alanine carboxypeptidase
HQ397_08810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HQ397_08820	COG0436	Aminotransferase
HQ397_08825	COG1288	antiporter activity
HQ397_08830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ397_08845	COG0697	spore germination
HQ397_08850	COG4657	Part of a membrane complex involved in electron transport
HQ397_08855	COG2878	Part of a membrane complex involved in electron transport
HQ397_08865	COG4658	electron transport chain
HQ397_08870	COG4659	FMN binding
HQ397_08875	COG4660	Part of a membrane complex involved in electron transport
HQ397_08880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQ397_08885	COG0346	lactoylglutathione lyase activity
HQ397_08900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ397_08905	COG2056	Na+-H+ antiporter family
HQ397_08915	COG2050	protein possibly involved in aromatic compounds catabolism
HQ397_08935	COG1253	flavin adenine dinucleotide binding
HQ397_08940	COG1902	pentaerythritol trinitrate reductase activity
HQ397_08945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HQ397_08950	COG0647	UMP catabolic process
HQ397_08955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQ397_08955	COG4651	solute:proton antiporter activity
HQ397_08965	COG0367	asparagine synthase
HQ397_08980	COG0625	glutathione transferase activity
HQ397_08990	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HQ397_09010	COG5001	Diguanylate cyclase
HQ397_09015	COG0840	transmembrane signaling receptor activity
HQ397_09025	COG0392	lysyltransferase activity
HQ397_09025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HQ397_09040	COG2194	sulfuric ester hydrolase activity
HQ397_09055	COG1317	bacterial-type flagellum organization
HQ397_09220	COG4790	Type iii secretion
HQ397_09225	COG4794	Type iii secretion
HQ397_09230	COG4791	protein targeting
HQ397_09235	COG4792	protein secretion
HQ397_09255	COG0670	Belongs to the BI1 family
HQ397_09260	COG1289	transmembrane transporter activity
HQ397_09265	COG2920	part of a sulfur-relay system
HQ397_09270	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HQ397_09275	COG0285	dihydrofolate synthase activity
HQ397_09280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQ397_09295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ397_09300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ397_09305	COG0671	phosphoesterase, PA-phosphatase related
HQ397_09310	COG1464	Belongs to the NlpA lipoprotein family
HQ397_09350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HQ397_09350	COG0574	Belongs to the PEP-utilizing enzyme family
HQ397_09355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HQ397_09415	COG1242	4 iron, 4 sulfur cluster binding
HQ397_09425	COG0493	'glutamate synthase
HQ397_09430	COG1126	abc transporter atp-binding protein
HQ397_09435	COG0765	amino acid transport
HQ397_09440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_09455	COG0789	Transcriptional regulator
HQ397_09480	COG0513	Belongs to the DEAD box helicase family
HQ397_09485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ397_09515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQ397_09525	COG0505	Belongs to the CarA family
HQ397_09530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQ397_09540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQ397_09545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HQ397_09550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ397_09555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ397_09560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ397_09570	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HQ397_09580	COG2205	protein histidine kinase activity
HQ397_09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_09620	COG0023	Translation Initiation Factor
HQ397_09625	COG2119	membrane
HQ397_09655	COG2199	diguanylate cyclase activity
HQ397_09655	COG2203	Gaf domain
HQ397_09685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ397_09695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ397_09700	COG3301	Polysulphide reductase, NrfD
HQ397_09705	COG0437	4 iron, 4 sulfur cluster binding
HQ397_09710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HQ397_09865	COG0322	excinuclease ABC activity
HQ397_09870	COG2197	response regulator
HQ397_09875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ397_09880	COG2835	tetraacyldisaccharide 4'-kinase activity
HQ397_09885	COG1663	tetraacyldisaccharide 4'-kinase activity
HQ397_09895	COG2333	competence protein COMEC
HQ397_09895	COG0658	competence protein
HQ397_09935	COG2267	carboxylic ester hydrolase activity
HQ397_09940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HQ397_09955	COG0314	molybdopterin synthase activity
HQ397_09960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HQ397_09965	COG0315	cyclic pyranopterin monophosphate synthase activity
HQ397_09970	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ397_09975	COG3005	denitrification pathway
HQ397_09985	COG0348	domain, Protein
HQ397_09990	COG0437	4 iron, 4 sulfur cluster binding
HQ397_09995	COG0243	molybdopterin cofactor binding
HQ397_10005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_10005	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ397_10010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQ397_10015	COG3850	Histidine kinase
HQ397_10020	COG2197	response regulator
HQ397_10055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ397_10065	COG0784	Response regulator, receiver
HQ397_10065	COG3437	response regulator, receiver
HQ397_10070	COG2239	Acts as a magnesium transporter
HQ397_10090	COG1706	bacterial-type flagellum-dependent cell motility
HQ397_10095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ397_10105	COG4787	bacterial-type flagellum-dependent cell motility
HQ397_10110	COG1749	Flagellar hook protein flgE
HQ397_10125	COG1815	bacterial-type flagellum-dependent cell motility
HQ397_10130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQ397_10135	COG0835	chemotaxis
HQ397_10135	COG0784	Response regulator, receiver
HQ397_10140	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HQ397_10155	COG0622	Phosphoesterase
HQ397_10185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ397_10190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ397_10200	COG1349	DNA-binding transcription factor activity
HQ397_10205	COG0697	spore germination
HQ397_10210	COG4166	transmembrane transport
HQ397_10235	COG1278	Cold shock
HQ397_10275	COG3132	Protein of unknown function, DUF480
HQ397_10285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HQ397_10295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HQ397_10300	COG1091	dTDP-4-dehydrorhamnose reductase activity
HQ397_10315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ397_10345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ397_10350	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HQ397_10370	COG0438	transferase activity, transferring glycosyl groups
HQ397_10410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_10415	COG1309	transcriptional regulator
HQ397_10430	COG1946	Acyl-CoA thioesterase
HQ397_10440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HQ397_10450	COG0009	L-threonylcarbamoyladenylate synthase
HQ397_10460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQ397_10465	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ397_10465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ397_10470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ397_10475	COG0134	indole-3-glycerol-phosphate synthase activity
HQ397_10475	COG0135	phosphoribosylanthranilate isomerase activity
HQ397_10480	COG0133	tryptophan synthase activity
HQ397_10485	COG0159	tryptophan synthase activity
HQ397_10545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ397_10560	COG3152	Membrane
HQ397_10575	COG2814	Major facilitator Superfamily
HQ397_10580	COG0109	protoheme IX farnesyltransferase activity
HQ397_10585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HQ397_10590	COG1845	cytochrome c oxidase, subunit III
HQ397_10595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HQ397_10600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQ397_10650	COG2211	Major facilitator Superfamily
HQ397_10665	COG0708	Exodeoxyribonuclease III
HQ397_10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_10690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ397_10710	COG0095	Lipoate-protein ligase
HQ397_10740	COG0640	Transcriptional regulator
HQ397_10755	COG1285	pathogenesis
HQ397_10785	COG0484	heat shock protein binding
HQ397_10790	COG0443	Heat shock 70 kDa protein
HQ397_10795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQ397_10800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQ397_10805	COG0497	DNA recombination
HQ397_10810	COG1227	inorganic diphosphatase activity
HQ397_10820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_10825	COG0577	efflux transmembrane transporter activity
HQ397_10825	COG1136	(ABC) transporter
HQ397_10835	COG2375	cellular response to nickel ion
HQ397_10840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ397_10860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ397_10865	COG1396	sequence-specific DNA binding
HQ397_10865	COG1917	Cupin 2, conserved barrel domain protein
HQ397_10880	COG0531	amino acid
HQ397_10890	COG0531	amino acid
HQ397_10900	COG1283	sodium-dependent phosphate transmembrane transporter activity
HQ397_10910	COG3384	dioxygenase
HQ397_10915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_10915	COG2205	protein histidine kinase activity
HQ397_10930	COG0813	purine-nucleoside phosphorylase activity
HQ397_10950	COG0488	(ABC) transporter
HQ397_10965	COG4319	ketosteroid isomerase
HQ397_10970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ397_10975	COG0083	homoserine kinase activity
HQ397_10985	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HQ397_10990	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HQ397_11005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ397_11015	COG0745	RESPONSE REGULATOR receiver
HQ397_11030	COG4988	ABC transporter
HQ397_11035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HQ397_11055	COG1720	tRNA m6t6A37 methyltransferase activity
HQ397_11070	COG0542	response to heat
HQ397_11075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HQ397_11080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_11090	COG2190	(PTS) system
HQ397_11105	COG3038	cytochrome b561
HQ397_11120	COG0419	ATPase involved in DNA repair
HQ397_11125	COG0420	3'-5' exonuclease activity
HQ397_11135	COG2974	May be involved in recombination
HQ397_11145	COG4651	solute:proton antiporter activity
HQ397_11145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQ397_11155	COG0469	pyruvate kinase activity
HQ397_11160	COG1196	nuclear chromosome segregation
HQ397_11160	COG3264	Mechanosensitive ion channel
HQ397_11190	COG0281	malic enzyme
HQ397_11205	COG0437	4 iron, 4 sulfur cluster binding
HQ397_11210	COG3383	formate dehydrogenase (NAD+) activity
HQ397_11210	COG3383	formate dehydrogenase (NAD+) activity
HQ397_11245	COG0653	protein targeting
HQ397_11250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ397_11260	COG3852	Histidine kinase
HQ397_11265	COG2204	response regulator
HQ397_11275	COG4662	Binding-protein-dependent transport system inner membrane component
HQ397_11285	COG0746	molybdenum cofactor guanylyltransferase activity
HQ397_11290	COG0303	'Molybdopterin
HQ397_11295	COG1289	transmembrane transporter activity
HQ397_11300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ397_11330	COG3220	belongs to the UPF0276 family
HQ397_11365	COG4166	transmembrane transport
HQ397_11370	COG0601	transmembrane transport
HQ397_11375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ397_11385	COG4608	Belongs to the ABC transporter superfamily
HQ397_11395	COG2971	BadF BadG BcrA BcrD
HQ397_11405	COG0840	transmembrane signaling receptor activity
HQ397_11425	COG3724	N-succinylarginine dihydrolase activity
HQ397_11430	COG0616	signal peptide processing
HQ397_11435	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_11440	COG0583	DNA-binding transcription factor activity
HQ397_11450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ397_11460	COG0583	DNA-binding transcription factor activity
HQ397_11465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQ397_11470	COG1881	PFAM PEBP family protein
HQ397_11480	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HQ397_11480	COG3408	Glycogen debranching enzyme
HQ397_11485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ397_11490	COG0739	heme binding
HQ397_11495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HQ397_11515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HQ397_11525	COG3091	SprT-like family
HQ397_11535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQ397_11540	COG0189	ligase activity
HQ397_11550	COG1678	Uncharacterized ACR, COG1678
HQ397_11555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQ397_11560	COG3104	oligopeptide transport
HQ397_11570	COG0714	Associated with various cellular activities
HQ397_11590	COG1115	amino acid carrier protein
HQ397_11595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ397_11610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQ397_11620	COG1301	dicarboxylic acid transport
HQ397_11630	COG2912	Transglutaminase-like superfamily
HQ397_11640	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ397_11645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ397_11650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQ397_11655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HQ397_11660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQ397_11670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ397_11675	COG0737	Belongs to the 5'-nucleotidase family
HQ397_11680	COG0193	aminoacyl-tRNA hydrolase activity
HQ397_11685	COG0012	GTP binding
HQ397_11730	COG0471	metal ion transport
HQ397_11730	COG0490	domain, Protein
HQ397_11760	COG0366	Alpha amylase catalytic
HQ397_11780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ397_11780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ397_11780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ397_11780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ397_11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ397_11800	COG1012	belongs to the aldehyde dehydrogenase family
HQ397_11810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQ397_11825	COG0180	Tryptophanyl-tRNA synthetase
HQ397_11835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQ397_11845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HQ397_11855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ397_11860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQ397_11890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ397_11895	COG0583	DNA-binding transcription factor activity
HQ397_11915	COG0583	DNA-binding transcription factor activity
HQ397_11930	COG0739	heme binding
HQ397_11940	COG3264	Mechanosensitive ion channel
HQ397_11940	COG1511	domain protein
HQ397_11945	COG0584	glycerophosphoryl diester phosphodiesterase
HQ397_11955	COG1053	succinate dehydrogenase
HQ397_11960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HQ397_11965	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HQ397_11990	COG3214	Protein conserved in bacteria
HQ397_12030	COG0642	Histidine kinase
HQ397_12050	COG0516	GMP reductase activity
HQ397_12065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQ397_12070	COG3647	Membrane
HQ397_12080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ397_12100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ397_12115	COG3706	GGDEF domain
HQ397_12125	COG1335	isochorismatase
HQ397_12130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ397_12135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ397_12140	COG1702	phosphate starvation-inducible protein PhoH
HQ397_12145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQ397_12150	COG4535	Mg2 and Co2 transporter CorC
HQ397_12155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HQ397_12160	COG2888	peptidyl-tyrosine sulfation
HQ397_12165	COG0495	leucyl-tRNA aminoacylation
HQ397_12180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQ397_12185	COG0799	negative regulation of ribosome biogenesis
HQ397_12190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HQ397_12195	COG0768	penicillin binding
HQ397_12200	COG0772	Belongs to the SEDS family
HQ397_12205	COG2951	lytic endotransglycosylase activity
HQ397_12210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQ397_12215	COG1686	Belongs to the peptidase S11 family
HQ397_12220	COG2921	Belongs to the UPF0250 family
HQ397_12225	COG0321	lipoyl(octanoyl) transferase activity
HQ397_12230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQ397_12240	COG3545	Serine hydrolase
HQ397_12245	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ397_12260	COG0789	Transcriptional regulator
HQ397_12270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ397_12275	COG1970	mechanosensitive ion channel activity
HQ397_12280	COG4974	Belongs to the 'phage' integrase family
HQ397_12290	COG0312	modulator of DNA gyrase
HQ397_12295	COG0312	modulator of DNA gyrase
HQ397_12360	COG3275	phosphorelay sensor kinase activity
HQ397_12365	COG3279	Response regulator of the LytR AlgR family
HQ397_12370	COG1966	Carbon starvation protein
HQ397_12380	COG0114	fumarate hydratase activity
HQ397_12390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ397_12400	COG2211	Major facilitator Superfamily
HQ397_12405	COG1185	polyribonucleotide nucleotidyltransferase activity
HQ397_12410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQ397_12415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQ397_12420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQ397_12425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQ397_12430	COG0195	Participates in both transcription termination and antitermination
HQ397_12435	COG0779	Required for maturation of 30S ribosomal subunits
HQ397_12450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HQ397_12455	COG0149	triose-phosphate isomerase activity
HQ397_12460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ397_12465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQ397_12475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HQ397_12480	COG1534	Rna-binding protein
HQ397_12495	COG1360	Flagellar Motor Protein
HQ397_12500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ397_12505	COG1722	exodeoxyribonuclease VII activity
HQ397_12510	COG0142	geranyltranstransferase activity
HQ397_12515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQ397_12525	COG0601	transmembrane transport
HQ397_12535	COG4172	Belongs to the ABC transporter superfamily
HQ397_12540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HQ397_12545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQ397_12550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ397_12555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HQ397_12575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ397_12575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ397_12580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQ397_12590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQ397_12605	COG3381	protein complex oligomerization
HQ397_12625	COG5001	Diguanylate cyclase
HQ397_12625	COG3300	MHYT domain
HQ397_12635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ397_12640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQ397_12645	COG0511	ligase activity, forming carbon-carbon bonds
HQ397_12650	COG0439	Biotin carboxylase
HQ397_12660	COG4145	pantothenate transmembrane transporter activity
HQ397_12665	COG1263	PTS System
HQ397_12665	COG2190	(PTS) system
HQ397_12665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_12675	COG0604	alcohol dehydrogenase
HQ397_12680	COG2264	protein methyltransferase activity
HQ397_12695	COG0778	Nitroreductase
HQ397_12700	COG1902	pentaerythritol trinitrate reductase activity
HQ397_12700	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ397_12705	COG0616	signal peptide processing
HQ397_12725	COG3139	Protein of unknown function (DUF1315)
HQ397_12730	COG0252	asparaginase activity
HQ397_12735	COG0786	glutamate:sodium symporter activity
HQ397_12750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQ397_12755	COG0384	phenazine biosynthesis protein PhzF
HQ397_12760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HQ397_12765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ397_12770	COG0175	sulfate reduction
HQ397_12775	COG2113	Glycine betaine
HQ397_12780	COG4176	ABC-type proline glycine betaine transport system permease component
HQ397_12785	COG4175	Glycine betaine
HQ397_12795	COG3610	response to peptide
HQ397_12800	COG2966	Psort location CytoplasmicMembrane, score
HQ397_12810	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ397_12820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ397_12825	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_12835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ397_12885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ397_12890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ397_12925	COG1858	cytochrome C peroxidase
HQ397_12935	COG2313	pseudouridylate synthase activity
HQ397_12940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ397_12970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQ397_12985	COG1073	alpha beta
HQ397_12990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HQ397_12995	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ397_13000	COG4608	Belongs to the ABC transporter superfamily
HQ397_13005	COG0444	Belongs to the ABC transporter superfamily
HQ397_13015	COG4239	(ABC) transporter, permease
HQ397_13020	COG4174	ABC transporter (Permease)
HQ397_13035	COG0811	peptide transport
HQ397_13040	COG0811	peptide transport
HQ397_13045	COG0848	biopolymer transport protein
HQ397_13095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ397_13100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ397_13105	COG0840	transmembrane signaling receptor activity
HQ397_13115	COG1278	Cold shock
HQ397_13155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HQ397_13160	COG1162	GTPase activity
HQ397_13165	COG0688	phosphatidylethanolamine metabolic process
HQ397_13170	COG4628	conserved protein (DUF2132)
HQ397_13185	COG3059	membrane
HQ397_13190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ397_13205	COG5001	Diguanylate cyclase
HQ397_13205	COG3300	MHYT domain
HQ397_13210	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HQ397_13235	COG1132	(ABC) transporter
HQ397_13245	COG1404	Belongs to the peptidase S8 family
HQ397_13250	COG2897	thiosulfate sulfurtransferase activity
HQ397_13255	COG2066	Belongs to the glutaminase family
HQ397_13260	COG3171	Protein conserved in bacteria
HQ397_13265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQ397_13270	COG4935	Belongs to the peptidase S8 family
HQ397_13270	COG2234	aminopeptidase activity
HQ397_13275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ397_13280	COG2200	EAL domain
HQ397_13285	COG1090	epimerase
HQ397_13290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HQ397_13295	COG4181	ATPase activity
HQ397_13300	COG2755	lipolytic protein G-D-S-L family
HQ397_13305	COG0784	Response regulator, receiver
HQ397_13305	COG0835	chemotaxis
HQ397_13320	COG2985	domain, Protein
HQ397_13320	COG0569	domain protein
HQ397_13325	COG1272	protein, Hemolysin III
HQ397_13330	COG0076	glutamate decarboxylase activity
HQ397_13335	COG2917	probably involved in intracellular septation
HQ397_13340	COG2350	Protein conserved in bacteria
HQ397_13350	COG1555	photosystem II stabilization
HQ397_13355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HQ397_13360	COG3104	oligopeptide transport
HQ397_13365	COG0745	RESPONSE REGULATOR receiver
HQ397_13395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_13410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HQ397_13440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ397_13445	COG0564	pseudouridine synthase activity
HQ397_13455	COG3300	MHYT domain
HQ397_13455	COG5001	Diguanylate cyclase
HQ397_13465	COG0459	protein refolding
HQ397_13470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQ397_13475	COG0534	Mate efflux family protein
HQ397_13480	COG3030	protein affecting phage T7 exclusion by the F plasmid
HQ397_13485	COG1027	Aspartate ammonia-lyase
HQ397_13490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ397_13500	COG0477	Major facilitator Superfamily
HQ397_13510	COG3227	Zinc metalloprotease (Elastase)
HQ397_13515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ397_13520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ397_13540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQ397_13545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ397_13550	COG3036	rescue of stalled ribosome
HQ397_13555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HQ397_13565	COG0138	bifunctional purine biosynthesis protein purh
HQ397_13570	COG0151	Belongs to the GarS family
HQ397_13595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ397_13600	COG0358	DNA primase activity
HQ397_13605	COG1610	YqeY-like protein
HQ397_13610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQ397_13615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQ397_13635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQ397_13645	COG0585	pseudouridine synthase activity
HQ397_13655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HQ397_13660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HQ397_13665	COG0148	phosphopyruvate hydratase activity
HQ397_13670	COG0504	CTP synthase activity
HQ397_13675	COG3956	TIGRFAM MazG family protein
HQ397_13680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ397_13685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ397_13695	COG4807	Protein conserved in bacteria
HQ397_13715	COG2222	sugar isomerase
HQ397_13720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_13730	COG3716	PTS system mannose fructose sorbose family IID component
HQ397_13735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_13740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ397_13755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQ397_13760	COG1381	Involved in DNA repair and RecF pathway recombination
HQ397_13770	COG0571	ribonuclease III activity
HQ397_13775	COG0681	Belongs to the peptidase S26 family
HQ397_13780	COG0481	GTPase activity
HQ397_13795	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HQ397_13800	COG1595	DNA-templated transcription, initiation
HQ397_13805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQ397_13815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HQ397_13820	COG0354	folic acid binding
HQ397_13860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ397_13870	COG0126	phosphoglycerate kinase activity
HQ397_13875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ397_13880	COG1940	carbohydrate kinase activity
HQ397_13885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQ397_13900	COG4991	sh3 domain protein
HQ397_13905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ397_13920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HQ397_13925	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_13940	COG1505	serine-type exopeptidase activity
HQ397_13945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ397_13950	COG0765	amino acid transport
HQ397_13955	COG0765	amino acid transport
HQ397_13960	COG1126	abc transporter atp-binding protein
HQ397_13965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_13970	COG0577	efflux transmembrane transporter activity
HQ397_13970	COG1136	(ABC) transporter
HQ397_13975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_13980	COG0745	RESPONSE REGULATOR receiver
HQ397_13985	COG2205	protein histidine kinase activity
HQ397_14025	COG2070	2-Nitropropane dioxygenase
HQ397_14055	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HQ397_14095	COG0513	Belongs to the DEAD box helicase family
HQ397_14120	COG2957	Belongs to the agmatine deiminase family
HQ397_14130	COG2852	Protein conserved in bacteria
HQ397_14140	COG1902	pentaerythritol trinitrate reductase activity
HQ397_14160	COG0456	acetyltransferase
HQ397_14190	COG0714	Associated with various cellular activities
HQ397_14200	COG0456	acetyltransferase
HQ397_14210	COG1022	Amp-dependent synthetase and ligase
HQ397_14220	COG2918	glutathione biosynthetic process
HQ397_14225	COG0612	Peptidase, M16
HQ397_14230	COG1238	metal cluster binding
HQ397_14255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ397_14260	COG0359	binds to the 23S rRNA
HQ397_14265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQ397_14270	COG0360	Binds together with S18 to 16S ribosomal RNA
HQ397_14275	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ397_14295	COG2153	protein acetylation
HQ397_14305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ397_14340	COG3706	GGDEF domain
HQ397_14345	COG1854	S-ribosylhomocysteine lyase activity
HQ397_14360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ397_14360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQ397_14420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQ397_14425	COG1047	Peptidyl-prolyl cis-trans
HQ397_14430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQ397_14435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HQ397_14440	COG0196	riboflavin kinase activity
HQ397_14450	COG0268	Binds directly to 16S ribosomal RNA
HQ397_14455	COG0640	Transcriptional regulator
HQ397_14460	COG0583	DNA-binding transcription factor activity
HQ397_14470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ397_14475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ397_14480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQ397_14490	COG1051	belongs to the nudix hydrolase family
HQ397_14495	COG3066	DNA modification
HQ397_14505	COG0335	large ribosomal subunit rRNA binding
HQ397_14510	COG0336	Belongs to the RNA methyltransferase TrmD family
HQ397_14515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQ397_14520	COG0228	four-way junction DNA binding
HQ397_14525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQ397_14530	COG4137	Cytochrome C assembly protein
HQ397_14535	COG4536	flavin adenine dinucleotide binding
HQ397_14545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ397_14545	COG1017	nitric oxide dioxygenase activity
HQ397_14550	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HQ397_14555	COG0039	L-malate dehydrogenase activity
HQ397_14560	COG4160	amino acid transport
HQ397_14565	COG4215	(ABC) transporter
HQ397_14570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_14575	COG1126	abc transporter atp-binding protein
HQ397_14580	COG1438	arginine binding
HQ397_14585	COG2837	iron assimilation
HQ397_14590	COG3842	ATPase activity
HQ397_14600	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ397_14605	COG0347	Belongs to the P(II) protein family
HQ397_14620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ397_14625	COG0583	DNA-binding transcription factor activity
HQ397_14640	COG1929	Belongs to the glycerate kinase type-1 family
HQ397_14645	COG2610	gluconate transmembrane transporter activity
HQ397_14650	COG3835	regulator
HQ397_14655	COG3112	Uncharacterised protein family (UPF0231)
HQ397_14670	COG0840	transmembrane signaling receptor activity
HQ397_14690	COG0513	Belongs to the DEAD box helicase family
HQ397_14745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ397_14750	COG1328	CTP reductase activity
HQ397_14800	COG0840	transmembrane signaling receptor activity
HQ397_14815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HQ397_14820	COG4208	sulfate ABC transporter
HQ397_14825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HQ397_14835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HQ397_14840	COG3174	membrane
HQ397_14845	COG0110	maltose O-acetyltransferase activity
HQ397_14870	COG0165	Argininosuccinate lyase
HQ397_14875	COG0137	argininosuccinate synthase activity
HQ397_14885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ397_14890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HQ397_14900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQ397_14910	COG0460	homoserine dehydrogenase
HQ397_14910	COG0527	aspartate kinase activity
HQ397_14915	COG0626	cystathionine gamma-synthase activity
HQ397_14925	COG3708	Transcriptional regulator
HQ397_14925	COG2207	Transcriptional regulator
HQ397_14930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ397_14935	COG0814	amino acid
HQ397_14940	COG1218	3'(2'),5'-bisphosphate nucleotidase
HQ397_14945	COG0494	nUDIX hydrolase
HQ397_14950	COG1011	Hydrolase
HQ397_14955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ397_14970	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HQ397_14980	COG3156	type II secretion system protein K
HQ397_14985	COG4795	General secretion pathway protein
HQ397_14990	COG2165	general secretion pathway protein
HQ397_15005	COG2165	general secretion pathway protein
HQ397_15010	COG1459	type II secretion system
HQ397_15015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ397_15025	COG3031	protein transport across the cell outer membrane
HQ397_15035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HQ397_15040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ397_15060	COG0456	acetyltransferase
HQ397_15065	COG3133	Outer membrane lipoprotein
HQ397_15080	COG2771	luxR family
HQ397_15085	COG3916	Acyl-homoserine-lactone synthase
HQ397_15095	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HQ397_15105	COG1309	transcriptional regulator
HQ397_15115	COG2213	PTS system mannitol-specific
HQ397_15115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_15120	COG0246	Mannitol dehydrogenase
HQ397_15125	COG3722	fumarate hydratase activity
HQ397_15130	COG3263	regulation of cellular component size
HQ397_15155	COG1671	Belongs to the UPF0178 family
HQ397_15170	COG1988	membrane-bound metal-dependent
HQ397_15175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ397_15180	COG0513	Belongs to the DEAD box helicase family
HQ397_15205	COG1575	Belongs to the MenA family. Type 1 subfamily
HQ397_15215	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HQ397_15220	COG0596	Alpha beta hydrolase
HQ397_15225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HQ397_15230	COG1441	menaquinone biosynthetic process
HQ397_15235	COG0318	PFAM AMP-dependent synthetase and ligase
HQ397_15255	COG3121	Chaperone
HQ397_15260	COG3188	usher protein
HQ397_15270	COG3539	Fimbrial protein
HQ397_15280	COG3291	Pkd domain containing protein
HQ397_15285	COG2949	membrane
HQ397_15290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HQ397_15300	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HQ397_15305	COG5380	lipid catabolic process
HQ397_15320	COG4533	DNA binding
HQ397_15330	COG2873	o-acetylhomoserine
HQ397_15340	COG1979	alcohol dehydrogenase
HQ397_15360	COG4221	oxidoreductase activity
HQ397_15380	COG1285	pathogenesis
HQ397_15400	COG1368	sulfuric ester hydrolase activity
HQ397_15405	COG1522	sequence-specific DNA binding
HQ397_15415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HQ397_15420	COG1418	mRNA catabolic process
HQ397_15425	COG1058	Belongs to the CinA family
HQ397_15425	COG1546	Belongs to the CinA family
HQ397_15435	COG0842	Transport permease protein
HQ397_15435	COG1129	ABC transporter
HQ397_15450	COG0561	phosphatase activity
HQ397_15455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HQ397_15475	COG1011	Hydrolase
HQ397_15490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQ397_15495	COG0019	diaminopimelate decarboxylase activity
HQ397_15505	COG1965	Belongs to the frataxin family
HQ397_15510	COG0400	carboxylic ester hydrolase activity
HQ397_15515	COG3072	Adenylate cyclase
HQ397_15520	COG0181	hydroxymethylbilane synthase activity
HQ397_15530	COG2959	enzyme of heme biosynthesis
HQ397_15545	COG1494	fructose-1,6-bisphosphatase
HQ397_15585	COG1733	regulation of RNA biosynthetic process
HQ397_15605	COG3932	Exopolysaccharide synthesis, ExoD
HQ397_15610	COG0814	amino acid
HQ397_15635	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HQ397_15650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ397_15655	COG2022	thiamine diphosphate biosynthetic process
HQ397_15665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ397_15670	COG0352	thiamine-phosphate diphosphorylase activity
HQ397_15675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HQ397_15680	COG0754	glutathionylspermidine amidase activity
HQ397_15710	COG0745	RESPONSE REGULATOR receiver
HQ397_15715	COG0642	Histidine kinase
HQ397_15725	COG0189	ligase activity
HQ397_15750	COG1639	'signal transduction protein
HQ397_15760	COG2321	neutral zinc metallopeptidase
HQ397_15765	COG3700	Belongs to the class B bacterial acid phosphatase family
HQ397_15790	COG1366	Belongs to the anti-sigma-factor antagonist family
HQ397_15795	COG2172	sigma factor antagonist activity
HQ397_15800	COG0784	Response regulator, receiver
HQ397_15800	COG2205	protein histidine kinase activity
HQ397_15800	COG5002	protein histidine kinase activity
HQ397_15805	COG3437	response regulator, receiver
HQ397_15815	COG0477	Major facilitator Superfamily
HQ397_15835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HQ397_15840	COG1263	PTS System
HQ397_15840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ397_15865	COG0312	modulator of DNA gyrase
HQ397_15870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ397_15880	COG3164	Protein of unknown function
HQ397_15885	COG1530	ribonuclease E activity
HQ397_15890	COG0424	maF-like protein
HQ397_15895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HQ397_15900	COG1792	Involved in formation and maintenance of cell shape
HQ397_15905	COG1077	Cell shape determining protein MreB Mrl
HQ397_15940	COG2165	general secretion pathway protein
HQ397_15950	COG1459	type II secretion system
HQ397_15955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ397_15965	COG2842	Transposition protein
HQ397_16005	COG2200	EAL domain
HQ397_16010	COG0387	Pfam Sodium calcium exchanger
HQ397_16015	COG2986	histidine ammonia-lyase
HQ397_16020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQ397_16025	COG0010	Belongs to the arginase family
HQ397_16030	COG1228	amidohydrolase
HQ397_16035	COG2188	Transcriptional regulator
HQ397_16040	COG0288	reversible hydration of carbon dioxide
HQ397_16050	COG2177	Part of the ABC transporter FtsEX involved in
HQ397_16055	COG2884	Cell division ATP-binding protein ftsE
HQ397_16060	COG0552	protein localization to endoplasmic reticulum
HQ397_16065	COG0742	ribosomal rna small subunit methyltransferase
HQ397_16090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ397_16100	COG0741	lytic transglycosylase activity
HQ397_16110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ397_16120	COG2095	MarC family integral membrane protein
HQ397_16130	COG1301	dicarboxylic acid transport
HQ397_16155	COG3714	YhhN family
HQ397_16175	COG1770	oligopeptidase
HQ397_16190	COG4221	oxidoreductase activity
HQ397_16195	COG0583	DNA-binding transcription factor activity
HQ397_16200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ397_16250	COG0203	ribosomal protein L17
HQ397_16255	COG0202	RNA polymerase activity
HQ397_16260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQ397_16265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQ397_16270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQ397_16275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ397_16280	COG0201	protein transport
HQ397_16285	COG0200	Binds to the 23S rRNA
HQ397_16290	COG1841	ribosomal large subunit assembly
HQ397_16295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQ397_16300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQ397_16305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQ397_16310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQ397_16315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQ397_16320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQ397_16325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQ397_16330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQ397_16335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQ397_16340	COG0255	Belongs to the universal ribosomal protein uL29 family
HQ397_16345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQ397_16350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQ397_16355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQ397_16360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQ397_16365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQ397_16370	COG0089	rRNA binding
HQ397_16375	COG0088	Forms part of the polypeptide exit tunnel
HQ397_16380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQ397_16385	COG0051	transcription antitermination factor activity, RNA binding
HQ397_16405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ397_16410	COG2183	response to ionizing radiation
HQ397_16430	COG0596	Alpha beta hydrolase
HQ397_16435	COG1040	competence protein
HQ397_16440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ397_16440	COG0316	Belongs to the HesB IscA family
HQ397_16445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQ397_16450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HQ397_16455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ397_16460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ397_16465	COG4942	peptidase
HQ397_16475	COG1609	Transcriptional regulator
HQ397_16480	COG0800	Aldolase
HQ397_16490	COG3265	gluconokinase activity
HQ397_16495	COG2610	gluconate transmembrane transporter activity
HQ397_16500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ397_16505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQ397_16515	COG0456	acetyltransferase
HQ397_16530	COG1490	D-aminoacyl-tRNA deacylase activity
HQ397_16535	COG1295	ribonuclease BN
HQ397_16540	COG1217	gtp-binding protein TYPA
HQ397_16545	COG0174	glutamine synthetase
HQ397_16555	COG3852	Histidine kinase
HQ397_16560	COG2204	response regulator
HQ397_16565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HQ397_16570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ397_16580	COG3078	GTPase activator activity
HQ397_16590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQ397_16600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQ397_16605	COG0408	coproporphyrinogen oxidase activity
HQ397_16610	COG0009	L-threonylcarbamoyladenylate synthase
HQ397_16620	COG0551	DNA topoisomerase type I activity
HQ397_16625	COG2922	Belongs to the Smg family
HQ397_16630	COG0758	DNA mediated transformation
HQ397_16640	COG0242	peptide deformylase activity
HQ397_16645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ397_16650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ397_16650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ397_16655	COG0569	domain protein
HQ397_16660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ397_16665	COG1322	Protein conserved in bacteria
HQ397_16685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ397_16690	COG0686	Belongs to the AlaDH PNT family
HQ397_16695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ397_16695	COG0519	Catalyzes the synthesis of GMP from XMP
HQ397_16705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HQ397_16710	COG1396	sequence-specific DNA binding
HQ397_16715	COG1012	belongs to the aldehyde dehydrogenase family
HQ397_16725	COG2962	Rard protein
HQ397_16735	COG1280	lysine exporter protein (LysE YggA)
HQ397_16745	COG2391	methyltransferase activity
HQ397_16800	COG0583	DNA-binding transcription factor activity
HQ397_16820	COG0210	DNA helicase
HQ397_16825	COG1744	ABC transporter substrate-binding protein PnrA-like
HQ397_16830	COG3845	ABC transporter
HQ397_16835	COG4603	Belongs to the binding-protein-dependent transport system permease family
HQ397_16840	COG1079	Belongs to the binding-protein-dependent transport system permease family
HQ397_16845	COG0583	DNA-binding transcription factor activity
HQ397_16865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ397_16870	COG0385	Bile acid
HQ397_16875	COG0531	amino acid
HQ397_16880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ397_16885	COG0531	amino acid
HQ397_16890	COG2731	YhcH YjgK YiaL family protein
HQ397_16895	COG3250	beta-galactosidase activity
HQ397_16900	COG1609	Transcriptional regulator
HQ397_16945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ397_16945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ397_16950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HQ397_16955	COG3074	FtsZ-dependent cytokinesis
HQ397_16965	COG1045	serine acetyltransferase
HQ397_16975	COG0745	RESPONSE REGULATOR receiver
HQ397_16980	COG2205	protein histidine kinase activity
HQ397_16985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HQ397_16990	COG0534	Mate efflux family protein
HQ397_17005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQ397_17010	COG2937	Belongs to the GPAT DAPAT family
HQ397_17015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HQ397_17020	COG3161	chorismate lyase activity
HQ397_17025	COG1580	Controls the rotational direction of flagella during chemotaxis
HQ397_17040	COG0604	alcohol dehydrogenase
HQ397_17045	COG1609	Transcriptional regulator
HQ397_17070	COG0859	PFAM glycosyl transferase family 9
HQ397_17075	COG0463	Glycosyl transferase, family 2
HQ397_17080	COG0859	PFAM glycosyl transferase family 9
HQ397_17085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQ397_17090	COG2990	Protein conserved in bacteria
HQ397_17095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HQ397_17105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQ397_17110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQ397_17115	COG2003	Belongs to the UPF0758 family
HQ397_17120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HQ397_17125	COG0756	dUTP diphosphatase activity
HQ397_17130	COG1309	transcriptional regulator
HQ397_17135	COG0668	transmembrane transport
HQ397_17145	COG0166	Belongs to the GPI family
HQ397_17150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQ397_17155	COG0583	DNA-binding transcription factor activity
HQ397_17170	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ397_17170	COG1042	CoA-binding domain protein
HQ397_17170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ397_17200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HQ397_17205	COG4206	TonB-dependent receptor
HQ397_17225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQ397_17230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQ397_17235	COG2223	nitrite transmembrane transporter activity
HQ397_17240	COG3279	Response regulator of the LytR AlgR family
HQ397_17245	COG3275	phosphorelay sensor kinase activity
HQ397_17255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_17255	COG2205	protein histidine kinase activity
HQ397_17275	COG3188	usher protein
HQ397_17295	COG2223	nitrite transmembrane transporter activity
HQ397_17305	COG1528	Iron-storage protein
HQ397_17315	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ397_17320	COG0589	response to stress
HQ397_17360	COG3642	lipopolysaccharide core region biosynthetic process
HQ397_17365	COG0859	PFAM glycosyl transferase family 9
HQ397_17375	COG1758	RNA polymerase activity
HQ397_17380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ397_17385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ397_17390	COG2267	carboxylic ester hydrolase activity
HQ397_17395	COG0561	phosphatase activity
HQ397_17425	COG1309	transcriptional regulator
HQ397_17430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ397_17440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ397_17440	COG4191	Histidine kinase
HQ397_17445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ397_17465	COG2205	protein histidine kinase activity
HQ397_17470	COG0745	RESPONSE REGULATOR receiver
HQ397_17475	COG2814	Major facilitator Superfamily
HQ397_17490	COG3977	Valine--pyruvate aminotransferase
HQ397_17495	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ397_17500	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ397_17505	COG2378	regulation of single-species biofilm formation
HQ397_17525	COG0592	DNA-directed DNA polymerase activity
HQ397_17530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQ397_17545	COG1126	abc transporter atp-binding protein
HQ397_17550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQ397_17555	COG0594	ribonuclease P activity
HQ397_17560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQ397_17565	COG0706	membrane insertase activity
HQ397_17570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQ397_17585	COG1120	ATPase activity
HQ397_17595	COG4774	siderophore transport
HQ397_17600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HQ397_17605	COG0445	tRNA wobble uridine modification
HQ397_17610	COG0357	Ribosomal RNA small subunit methyltransferase G
HQ397_17615	COG1192	Involved in chromosome partitioning
HQ397_17620	COG1475	DNA binding
HQ397_17630	COG0356	it plays a direct role in the translocation of protons across the membrane
HQ397_17640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQ397_17645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ397_17650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQ397_17655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQ397_17660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQ397_17665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQ397_17670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ397_17675	COG4452	Inner membrane protein CreD
HQ397_17685	COG2205	protein histidine kinase activity
HQ397_17690	COG0745	RESPONSE REGULATOR receiver
HQ397_17695	COG1349	DNA-binding transcription factor activity
HQ397_17700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQ397_17705	COG2771	luxR family
HQ397_17715	COG0811	peptide transport
HQ397_17720	COG0811	peptide transport
HQ397_17725	COG0848	biopolymer transport protein
HQ397_17730	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ397_17770	COG0402	S-adenosylhomocysteine deaminase activity
HQ397_17785	COG3165	ubiquinone biosynthetic process from chorismate
HQ397_17790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HQ397_17800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ397_17805	COG0805	protein transport
HQ397_17810	COG0084	hydrolase, TatD family'
HQ397_17830	COG0742	ribosomal rna small subunit methyltransferase
HQ397_17845	COG0248	Ppx GppA phosphatase
HQ397_17850	COG0513	Belongs to the DEAD box helicase family
HQ397_17855	COG3118	belongs to the thioredoxin family
HQ397_17870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HQ397_17895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ397_17935	COG1609	Transcriptional regulator
HQ397_17950	COG2188	Transcriptional regulator
HQ397_17955	COG3604	Transcriptional regulator
HQ397_17960	COG0426	domain, Protein
HQ397_17960	COG1773	rubredoxin
HQ397_17965	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ397_17975	COG0348	domain, Protein
HQ397_17980	COG0814	amino acid
HQ397_18015	COG0529	Catalyzes the synthesis of activated sulfate
HQ397_18015	COG2046	Belongs to the sulfate adenylyltransferase family
HQ397_18025	COG0751	glycine-tRNA ligase activity
HQ397_18030	COG0752	glycyl-tRNA synthetase alpha subunit
HQ397_18035	COG2818	Glycosylase
HQ397_18040	COG1335	isochorismatase
HQ397_18045	COG2885	chlorophyll binding
HQ397_18060	COG0251	oxidation-reduction process
HQ397_18065	COG0425	Belongs to the sulfur carrier protein TusA family
HQ397_18090	COG0183	Belongs to the thiolase family
HQ397_18095	COG1024	Enoyl-CoA hydratase
HQ397_18095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ397_18100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ397_18105	COG0006	proline dipeptidase activity
HQ397_18110	COG1739	Uncharacterized protein family UPF0029
HQ397_18115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ397_18120	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HQ397_18155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HQ397_18160	COG2166	iron-sulfur cluster assembly
HQ397_18165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQ397_18170	COG0210	DNA helicase
HQ397_18180	COG3245	cytochrome
HQ397_18190	COG0156	8-amino-7-oxononanoate synthase activity
HQ397_18200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ397_18215	COG3306	glycosyltransferase involved in LPS biosynthesis
HQ397_18235	COG1561	YicC-like family, N-terminal region
HQ397_18240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HQ397_18245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQ397_18255	COG0789	Transcriptional regulator
HQ397_18260	COG3706	GGDEF domain
HQ397_18260	COG4251	negative regulation of phosphorylation
HQ397_18260	COG2203	Gaf domain
HQ397_18260	COG5001	Diguanylate cyclase
HQ397_18265	COG3084	Protein conserved in bacteria
HQ397_18275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HQ397_18280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ397_18290	COG1335	isochorismatase
HQ397_18300	COG1683	Conserved Protein
HQ397_18305	COG0204	Acyl-transferase
HQ397_18315	COG0606	chelatase, subunit chli
HQ397_18325	COG3978	acetolactate synthase activity
HQ397_18335	COG0129	dihydroxy-acid dehydratase activity
HQ397_18355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQ397_18360	COG0254	rRNA binding
HQ397_18365	COG0702	epimerase
HQ397_18370	COG0281	malic enzyme
HQ397_18380	COG2205	protein histidine kinase activity
HQ397_18385	COG0745	RESPONSE REGULATOR receiver
HQ397_18390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ397_18425	COG4310	Domain of unknown function (DUF2172)
HQ397_18445	COG2089	acid synthase
HQ397_18455	COG1083	cytidylyl-transferase
HQ397_18470	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_18475	COG0318	PFAM AMP-dependent synthetase and ligase
HQ397_18490	COG1215	transferase activity, transferring glycosyl groups
HQ397_18530	COG0529	Catalyzes the synthesis of activated sulfate
HQ397_18540	COG0574	Belongs to the PEP-utilizing enzyme family
HQ397_18540	COG3848	Pyruvate phosphate dikinase
HQ397_18545	COG0519	Catalyzes the synthesis of GMP from XMP
HQ397_18550	COG4750	Nucleotidyl transferase
HQ397_18555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ397_18560	COG1086	Polysaccharide biosynthesis protein
HQ397_18565	COG0366	Alpha amylase catalytic
HQ397_18580	COG0443	Heat shock 70 kDa protein
HQ397_18585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ397_18590	COG3045	CreA protein
HQ397_18610	COG0174	glutamine synthetase
HQ397_18630	COG3842	ATPase activity
HQ397_18635	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ397_18640	COG1177	transmembrane transport
HQ397_18645	COG2258	MOSC domain
HQ397_18660	COG2050	protein possibly involved in aromatic compounds catabolism
HQ397_18665	COG0514	ATP-dependent DNA helicase (RecQ)
HQ397_18675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQ397_18685	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HQ397_18690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ397_18705	COG1648	precorrin-2 dehydrogenase activity
HQ397_18705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ397_18710	COG2116	formate transmembrane transporter activity
HQ397_18720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ397_18730	COG0477	Major facilitator Superfamily
HQ397_18740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HQ397_18745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HQ397_18770	COG1595	DNA-templated transcription, initiation
HQ397_18775	COG3806	Anti-sigma factor
HQ397_18780	COG1968	undecaprenyl-diphosphatase activity
HQ397_18785	COG0667	Aldo Keto reductase
HQ397_18790	COG2017	converts alpha-aldose to the beta-anomer
HQ397_18795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HQ397_18805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ397_18810	COG1609	Transcriptional regulator
HQ397_18815	COG3250	beta-galactosidase activity
HQ397_18835	COG0840	transmembrane signaling receptor activity
HQ397_18865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ397_18870	COG1288	antiporter activity
HQ397_18880	COG1438	arginine binding
HQ397_18885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HQ397_18890	COG0540	Belongs to the ATCase OTCase family
HQ397_18910	COG0688	phosphatidylethanolamine metabolic process
HQ397_18925	COG0583	DNA-binding transcription factor activity
HQ397_18935	COG3040	lipid binding
HQ397_18940	COG2207	Transcriptional regulator
HQ397_18945	COG1979	alcohol dehydrogenase
HQ397_18950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HQ397_18955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HQ397_18965	COG3681	Belongs to the UPF0597 family
HQ397_18975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ397_18980	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ397_18985	COG0564	pseudouridine synthase activity
HQ397_18995	COG0542	response to heat
HQ397_19000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ397_19005	COG2502	aspartate--ammonia ligase
HQ397_19010	COG1522	sequence-specific DNA binding
HQ397_19020	COG5413	integral membrane protein
HQ397_19045	COG2205	protein histidine kinase activity
HQ397_19055	COG2204	response regulator
HQ397_19070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HQ397_19100	COG0243	molybdopterin cofactor binding
HQ397_19105	COG3005	denitrification pathway
HQ397_19110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQ397_19130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ397_19135	COG0569	domain protein
HQ397_19140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQ397_19165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ397_19180	COG0250	Participates in transcription elongation, termination and antitermination
HQ397_19185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQ397_19190	COG0081	regulation of translation
HQ397_19195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQ397_19200	COG0222	ribosome binding
HQ397_19205	COG0085	RNA polymerase activity
HQ397_19210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQ397_19215	COG2964	Protein conserved in bacteria
HQ397_19220	COG0251	oxidation-reduction process
HQ397_19230	COG2923	Belongs to the DsrF TusC family
HQ397_19235	COG2168	tRNA wobble position uridine thiolation
HQ397_19240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQ397_19245	COG0049	tRNA binding
HQ397_19250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQ397_19255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ397_19260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ397_19295	COG2252	PERMEase
HQ397_19300	COG2376	Dihydroxyacetone kinase
HQ397_19305	COG1461	Dihydroxyacetone kinase
HQ397_19320	COG3284	Transcriptional regulator
HQ397_19325	COG0583	DNA-binding transcription factor activity
HQ397_19330	COG2957	Belongs to the agmatine deiminase family
HQ397_19335	COG4221	oxidoreductase activity
HQ397_19340	COG0628	permease
HQ397_19345	COG0494	nUDIX hydrolase
HQ397_19370	COG0753	catalase activity
HQ397_19375	COG1247	-acetyltransferase
HQ397_19405	COG3842	ATPase activity
HQ397_19415	COG1175	transmembrane transport
HQ397_19440	COG0583	DNA-binding transcription factor activity
HQ397_19450	COG1741	Belongs to the pirin family
HQ397_19455	COG2259	Doxx family
HQ397_19460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HQ397_19465	COG1074	ATP-dependent DNA helicase activity
HQ397_19470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HQ397_19540	COG4251	negative regulation of phosphorylation
HQ397_19540	COG5001	Diguanylate cyclase
HQ397_19540	COG2203	Gaf domain
HQ397_19540	COG3706	GGDEF domain
HQ397_19545	COG4771	TonB-dependent receptor
HQ397_19550	COG1278	Cold shock
HQ397_19570	COG0629	single-stranded DNA binding
HQ397_19575	COG2197	response regulator
HQ397_19580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQ397_19620	COG3135	benzoate transporter
HQ397_19625	COG1396	sequence-specific DNA binding
HQ397_19655	COG2926	Belongs to the UPF0265 family
HQ397_19665	COG3028	Belongs to the UPF0307 family
HQ397_19670	COG0312	modulator of DNA gyrase
HQ397_19675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQ397_19680	COG5007	Belongs to the BolA IbaG family
HQ397_19690	COG2854	intermembrane phospholipid transfer
HQ397_19695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ397_19700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ397_19705	COG1127	ABC transporter
HQ397_19710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ397_19710	COG0517	IMP dehydrogenase activity
HQ397_19715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQ397_19720	COG3117	lipopolysaccharide transmembrane transporter activity
HQ397_19725	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HQ397_19730	COG1137	ATPase activity
HQ397_19735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQ397_19745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_19750	COG1660	Displays ATPase and GTPase activities
HQ397_19755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ397_19775	COG3964	amidohydrolase
HQ397_19805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ397_19810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ397_19820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HQ397_19825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQ397_19830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQ397_19835	COG0723	plastoquinol--plastocyanin reductase activity
HQ397_19845	COG2857	Cytochrome c1
HQ397_19850	COG0625	glutathione transferase activity
HQ397_19855	COG2969	positive regulation of protein catabolic process
HQ397_19860	COG2823	Periplasmic or secreted lipoprotein
HQ397_19865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ397_19870	COG0792	nuclease activity
HQ397_19875	COG3107	peptidoglycan biosynthetic process
HQ397_19880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQ397_19930	COG1677	Flagellar hook-basal body complex protein FliE
HQ397_19940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ397_19975	COG1815	bacterial-type flagellum-dependent cell motility
HQ397_19990	COG1749	Flagellar hook protein flgE
HQ397_20000	COG4786	Flagellar basal body rod
HQ397_20005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ397_20010	COG1706	bacterial-type flagellum-dependent cell motility
HQ397_20020	COG1256	bacterial-type flagellum assembly
HQ397_20020	COG4786	Flagellar basal body rod
HQ397_20025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ397_20045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ397_20050	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HQ397_20075	COG1191	sigma factor activity
HQ397_20080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ397_20085	COG1360	Flagellar Motor Protein
HQ397_20095	COG1388	LysM domain
HQ397_20095	COG0741	lytic transglycosylase activity
HQ397_20105	COG2001	Belongs to the MraZ family
HQ397_20110	COG0275	rRNA processing
HQ397_20115	COG3116	cell division
HQ397_20120	COG0768	penicillin binding
HQ397_20130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQ397_20135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ397_20140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQ397_20145	COG0772	Belongs to the SEDS family
HQ397_20150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQ397_20155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ397_20160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HQ397_20165	COG0849	cell division
HQ397_20170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQ397_20175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQ397_20185	COG0653	protein targeting
HQ397_20195	COG0494	nUDIX hydrolase
HQ397_20200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HQ397_20205	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HQ397_20220	COG1459	type II secretion system
HQ397_20225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ397_20250	COG2186	Transcriptional regulator
HQ397_20255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HQ397_20260	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ397_20265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ397_20275	COG0840	transmembrane signaling receptor activity
HQ397_20280	COG0840	transmembrane signaling receptor activity
HQ397_20290	COG1049	propionate catabolic process, 2-methylcitrate cycle
HQ397_20295	COG2200	EAL domain
HQ397_20305	COG1280	lysine exporter protein (LysE YggA)
HQ397_20315	COG0523	cobalamin synthesis protein
HQ397_20320	COG0477	Major facilitator Superfamily
HQ397_20335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HQ397_20340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQ397_20380	COG3314	Sporulation integral membrane protein YlbJ
HQ397_20385	COG0835	chemotaxis
HQ397_20385	COG0784	Response regulator, receiver
HQ397_20390	COG1028	Short-chain dehydrogenase reductase Sdr
HQ397_20395	COG1444	tRNA N-acetyltransferase activity
HQ397_20420	COG1803	Methylglyoxal synthase
HQ397_20435	COG0252	asparaginase activity
HQ397_20460	COG0366	Alpha amylase catalytic
HQ397_20465	COG0110	maltose O-acetyltransferase activity
HQ397_20470	COG1522	sequence-specific DNA binding
HQ397_20515	COG1012	belongs to the aldehyde dehydrogenase family
HQ397_20520	COG1177	transmembrane transport
HQ397_20535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HQ397_20540	COG0583	DNA-binding transcription factor activity
HQ397_20545	COG1757	Na H antiporter
HQ397_20585	COG0297	glycogen (starch) synthase activity
HQ397_20590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ397_20595	COG2813	Specifically methylates the guanine in position
HQ397_20600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ397_20605	COG2203	Gaf domain
HQ397_20605	COG3706	GGDEF domain
HQ397_20605	COG5001	Diguanylate cyclase
HQ397_20605	COG4251	negative regulation of phosphorylation
HQ397_20615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ397_20625	COG2995	paraquat-inducible protein a
HQ397_20630	COG3008	intermembrane lipid transfer
HQ397_20630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ397_20635	COG3009	Protein conserved in bacteria
HQ397_20640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HQ397_20640	COG2885	chlorophyll binding
HQ397_20650	COG3240	lipase activity
HQ397_20655	COG3111	PFAM Bacterial OB fold (BOF) protein
HQ397_20665	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HQ397_20670	COG1194	a g-specific adenine glycosylase
HQ397_20680	COG3409	Peptidoglycan-binding domain 1 protein
HQ397_20680	COG3267	Type II secretory pathway component ExeA
HQ397_20685	COG0617	tRNA 3'-terminal CCA addition
HQ397_20700	COG1346	cytolysis
HQ397_20705	COG1380	Effector of murein hydrolase LrgA
HQ397_20710	COG0583	DNA-binding transcription factor activity
HQ397_20740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HQ397_20745	COG0306	phosphate transporter
HQ397_20750	COG1392	Phosphate transport regulator
HQ397_20765	COG1560	Kdo2-lipid A biosynthetic process
HQ397_20770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ397_20770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ397_20775	COG1538	Outer membrane efflux protein
HQ397_20780	COG0494	nUDIX hydrolase
HQ397_20785	COG3151	Protein conserved in bacteria
HQ397_20795	COG3150	esterase
HQ397_20800	COG1051	belongs to the nudix hydrolase family
HQ397_20815	COG1566	PFAM secretion protein HlyD family protein
HQ397_20820	COG1289	transmembrane transporter activity
HQ397_20875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ397_20895	COG0204	Acyl-transferase
HQ397_20900	COG1842	Phage shock protein A
HQ397_20915	COG2827	Endonuclease containing a URI domain
HQ397_20925	COG2962	Rard protein
HQ397_20930	COG1573	uracil-dna glycosylase
HQ397_20935	COG0697	spore germination
HQ397_20940	COG0583	DNA-binding transcription factor activity
HQ397_20945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HQ397_20950	COG1121	(ABC) transporter
HQ397_20955	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HQ397_20975	COG0739	heme binding
HQ397_20985	COG3068	Protein conserved in bacteria
HQ397_21005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ397_21010	COG1546	Belongs to the CinA family
HQ397_21015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ397_21025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQ397_21030	COG0527	aspartate kinase activity
HQ397_21035	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HQ397_21075	COG0586	Pfam SNARE associated Golgi protein
HQ397_21080	COG1253	flavin adenine dinucleotide binding
HQ397_21085	COG0525	valine-tRNA ligase activity
HQ397_21090	COG2927	DNA polymerase III (CHI subunit)
HQ397_21095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ397_21100	COG0795	lipopolysaccharide-transporting ATPase activity
HQ397_21105	COG0795	lipopolysaccharide-transporting ATPase activity
HQ397_21240	COG4695	Portal protein
HQ397_21330	COG4974	Belongs to the 'phage' integrase family
HQ397_21335	COG0004	ammonium transporteR
HQ397_21340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ397_21350	COG2165	general secretion pathway protein
HQ397_21355	COG0084	hydrolase, TatD family'
HQ397_21360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ397_21370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQ397_21375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HQ397_21380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HQ397_21385	COG0813	purine-nucleoside phosphorylase activity
HQ397_21390	COG5002	protein histidine kinase activity
HQ397_21390	COG5001	Diguanylate cyclase
HQ397_21390	COG3447	MASE1 domain protein
HQ397_21400	COG0560	Phosphoserine phosphatase
HQ397_21425	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HQ397_21435	COG0776	regulation of translation
HQ397_21450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ397_21455	COG0735	belongs to the Fur family
HQ397_21480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HQ397_21485	COG0513	Belongs to the DEAD box helicase family
HQ397_21490	COG3022	response to hydroperoxide
HQ397_21505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQ397_21510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HQ397_21515	COG0762	integral membrane protein
HQ397_21520	COG1872	DUF167
HQ397_21535	COG4166	transmembrane transport
HQ397_21555	COG1024	Enoyl-CoA hydratase
HQ397_21570	COG4221	oxidoreductase activity
HQ397_21575	COG0442	prolyl-tRNA aminoacylation
HQ397_21580	COG0840	transmembrane signaling receptor activity
HQ397_21585	COG0632	four-way junction helicase activity
HQ397_21590	COG2255	four-way junction helicase activity
HQ397_21595	COG1271	oxidase subunit
HQ397_21600	COG1294	oxidase, subunit
HQ397_21605	COG4890	Cyd operon protein YbgT
HQ397_21610	COG3790	cyd operon protein YbgE
HQ397_21615	COG0824	Thioesterase
HQ397_21620	COG0811	peptide transport
HQ397_21635	COG0823	Involved in the tonB-independent uptake of proteins
HQ397_21640	COG2885	chlorophyll binding
HQ397_21645	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HQ397_21720	COG0840	transmembrane signaling receptor activity
HQ397_21725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQ397_21730	COG0676	glucose-6-phosphate 1-epimerase activity
HQ397_21735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ397_21740	COG1640	4-alpha-glucanotransferase
HQ397_21745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ397_21765	COG1051	belongs to the nudix hydrolase family
HQ397_21770	COG2130	NADP-dependent
HQ397_21775	COG1764	response to oxidative stress
HQ397_21780	COG1846	Transcriptional regulator
HQ397_21815	COG0561	phosphatase activity
HQ397_21830	COG0733	neurotransmitter:sodium symporter activity
HQ397_21840	COG0733	neurotransmitter:sodium symporter activity
HQ397_21865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ397_21880	COG1794	racemase activity, acting on amino acids and derivatives
HQ397_21895	COG2731	YhcH YjgK YiaL family protein
HQ397_21905	COG0668	transmembrane transport
HQ397_21915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ397_21925	COG0789	Transcriptional regulator
HQ397_21965	COG0583	DNA-binding transcription factor activity
HQ397_21970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HQ397_21980	COG0488	(ABC) transporter
HQ397_21985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ397_21985	COG0517	IMP dehydrogenase activity
HQ397_21990	COG1585	Membrane protein implicated in regulation of membrane protease activity
HQ397_21995	COG0330	HflC and HflK could
HQ397_22000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ397_22000	COG1648	precorrin-2 dehydrogenase activity
HQ397_22005	COG0175	sulfate reduction
HQ397_22010	COG2895	sulfate adenylyltransferase (ATP) activity
HQ397_22015	COG0471	metal ion transport
HQ397_22015	COG3273	potassium ion transport
HQ397_22020	COG0529	Catalyzes the synthesis of activated sulfate
HQ397_22040	COG0840	transmembrane signaling receptor activity
HQ397_22060	COG1136	(ABC) transporter
HQ397_22075	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HQ397_22090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQ397_22095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ397_22100	COG0163	prenyltransferase activity
HQ397_22115	COG1131	(ABC) transporter
HQ397_22120	COG0842	Transport permease protein
HQ397_22125	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HQ397_22130	COG1924	4 iron, 4 sulfur cluster binding
HQ397_22160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQ397_22165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQ397_22180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ397_22185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ397_22190	COG1489	DNA binding
HQ397_22205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ397_22210	COG0346	lactoylglutathione lyase activity
HQ397_22220	COG2076	Multidrug Resistance protein
HQ397_22230	COG3437	response regulator, receiver
HQ397_22230	COG0784	Response regulator, receiver
HQ397_22240	COG0671	phosphoesterase, PA-phosphatase related
HQ397_22255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ397_22260	COG0038	chloride channel
HQ397_22270	COG0316	Belongs to the HesB IscA family
HQ397_22300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ397_22310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HQ397_22320	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HQ397_22325	COG1178	ABC-type Fe3 transport system permease component
HQ397_22345	COG0066	3-isopropylmalate dehydratase activity
HQ397_22350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQ397_22355	COG0473	3-isopropylmalate dehydrogenase activity
HQ397_22360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQ397_22370	COG0671	phosphoesterase, PA-phosphatase related
HQ397_22385	COG0028	Belongs to the TPP enzyme family
HQ397_22395	COG0280	phosphate acetyltransferase
HQ397_22395	COG0857	belongs to the CobB CobQ family
HQ397_22400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ397_22410	COG3013	Belongs to the UPF0304 family
HQ397_22415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQ397_22420	COG2716	regulation of RNA biosynthetic process
HQ397_22430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HQ397_22435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQ397_22450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)