locus-tag	class	description
AH4AK4_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AH4AK4_0002	COG0592	DNA-directed DNA polymerase activity
AH4AK4_0004	COG0187	DNA topoisomerase II activity
AH4AK4_0006	COG2378	regulation of single-species biofilm formation
AH4AK4_0009	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AH4AK4_0010	COG0071	Belongs to the small heat shock protein (HSP20) family
AH4AK4_0011	COG0071	Belongs to the small heat shock protein (HSP20) family
AH4AK4_0012	COG3977	Valine--pyruvate aminotransferase
AH4AK4_0016	COG2814	Major facilitator Superfamily
AH4AK4_0017	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0018	COG2205	protein histidine kinase activity
AH4AK4_0023	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH4AK4_0024	COG4191	Histidine kinase
AH4AK4_0024	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_0025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_0026	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_0027	COG1309	transcriptional regulator
AH4AK4_0033	COG0561	phosphatase activity
AH4AK4_0034	COG2267	carboxylic ester hydrolase activity
AH4AK4_0036	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH4AK4_0037	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH4AK4_0038	COG1758	RNA polymerase activity
AH4AK4_0039	COG0194	GDP metabolic process
AH4AK4_0040	COG0859	PFAM glycosyl transferase family 9
AH4AK4_0043	COG0697	spore germination
AH4AK4_0049	COG0589	response to stress
AH4AK4_0050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AH4AK4_0051	COG3706	GGDEF domain
AH4AK4_0052	COG1528	Iron-storage protein
AH4AK4_0053	COG2081	HI0933 family
AH4AK4_0054	COG2223	nitrite transmembrane transporter activity
AH4AK4_0058	COG3188	usher protein
AH4AK4_0062	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_0062	COG2205	protein histidine kinase activity
AH4AK4_0064	COG3275	phosphorelay sensor kinase activity
AH4AK4_0065	COG3279	Response regulator of the LytR AlgR family
AH4AK4_0066	COG2223	nitrite transmembrane transporter activity
AH4AK4_0067	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AH4AK4_0068	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AH4AK4_0069	COG4206	TonB-dependent receptor
AH4AK4_0070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AH4AK4_0077	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AH4AK4_0078	COG2166	iron-sulfur cluster assembly
AH4AK4_0079	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AH4AK4_0081	COG0210	DNA helicase
AH4AK4_0085	COG1063	alcohol dehydrogenase
AH4AK4_0088	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AH4AK4_0098	COG1609	Transcriptional regulator
AH4AK4_0099	COG0604	alcohol dehydrogenase
AH4AK4_0103	COG1580	Controls the rotational direction of flagella during chemotaxis
AH4AK4_0104	COG3161	chorismate lyase activity
AH4AK4_0105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AH4AK4_0106	COG2937	Belongs to the GPAT DAPAT family
AH4AK4_0107	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AH4AK4_0110	COG0534	Mate efflux family protein
AH4AK4_0111	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AH4AK4_0112	COG2205	protein histidine kinase activity
AH4AK4_0113	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0115	COG1045	serine acetyltransferase
AH4AK4_0117	COG3074	FtsZ-dependent cytokinesis
AH4AK4_0118	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AH4AK4_0119	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_0119	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_0120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AH4AK4_0128	COG1609	Transcriptional regulator
AH4AK4_0129	COG3250	beta-galactosidase activity
AH4AK4_0130	COG2731	YhcH YjgK YiaL family protein
AH4AK4_0131	COG0531	amino acid
AH4AK4_0132	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_0133	COG0531	amino acid
AH4AK4_0134	COG0385	Bile acid
AH4AK4_0140	COG0583	DNA-binding transcription factor activity
AH4AK4_0147	COG0210	DNA helicase
AH4AK4_0150	COG1943	Transposase
AH4AK4_0151	COG1943	Transposase
AH4AK4_0152	COG0583	DNA-binding transcription factor activity
AH4AK4_0154	COG1733	regulation of RNA biosynthetic process
AH4AK4_0160	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_0163	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AH4AK4_0170	COG0583	DNA-binding transcription factor activity
AH4AK4_0171	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_0172	COG2391	methyltransferase activity
AH4AK4_0174	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_0176	COG2962	Rard protein
AH4AK4_0179	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_0180	COG1396	sequence-specific DNA binding
AH4AK4_0183	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AH4AK4_0183	COG0519	Catalyzes the synthesis of GMP from XMP
AH4AK4_0185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_0189	COG1322	Protein conserved in bacteria
AH4AK4_0190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_0191	COG0569	domain protein
AH4AK4_0192	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_0192	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_0193	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AH4AK4_0194	COG0242	peptide deformylase activity
AH4AK4_0196	COG0758	DNA mediated transformation
AH4AK4_0197	COG2922	Belongs to the Smg family
AH4AK4_0198	COG0551	DNA topoisomerase type I activity
AH4AK4_0199	COG0009	L-threonylcarbamoyladenylate synthase
AH4AK4_0200	COG0408	coproporphyrinogen oxidase activity
AH4AK4_0201	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AH4AK4_0202	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AH4AK4_0204	COG3078	GTPase activator activity
AH4AK4_0206	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AH4AK4_0207	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AH4AK4_0209	COG3852	Histidine kinase
AH4AK4_0211	COG0174	glutamine synthetase
AH4AK4_0213	COG1295	ribonuclease BN
AH4AK4_0214	COG1490	D-aminoacyl-tRNA deacylase activity
AH4AK4_0216	COG0456	acetyltransferase
AH4AK4_0218	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AH4AK4_0219	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AH4AK4_0220	COG2610	gluconate transmembrane transporter activity
AH4AK4_0221	COG3265	gluconokinase activity
AH4AK4_0222	COG0129	dihydroxy-acid dehydratase activity
AH4AK4_0223	COG0800	Aldolase
AH4AK4_0226	COG1609	Transcriptional regulator
AH4AK4_0229	COG4942	peptidase
AH4AK4_0230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AH4AK4_0231	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_0232	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AH4AK4_0233	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AH4AK4_0234	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AH4AK4_0234	COG0316	Belongs to the HesB IscA family
AH4AK4_0235	COG1040	competence protein
AH4AK4_0236	COG0596	Alpha beta hydrolase
AH4AK4_0239	COG2183	response to ionizing radiation
AH4AK4_0241	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH4AK4_0242	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0243	COG2205	protein histidine kinase activity
AH4AK4_0245	COG0051	transcription antitermination factor activity, RNA binding
AH4AK4_0246	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AH4AK4_0247	COG0088	Forms part of the polypeptide exit tunnel
AH4AK4_0248	COG0089	rRNA binding
AH4AK4_0249	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AH4AK4_0251	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AH4AK4_0252	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AH4AK4_0253	COG0255	Belongs to the universal ribosomal protein uL29 family
AH4AK4_0254	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AH4AK4_0255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AH4AK4_0256	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AH4AK4_0257	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AH4AK4_0258	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AH4AK4_0259	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AH4AK4_0260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AH4AK4_0261	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AH4AK4_0262	COG1841	ribosomal large subunit assembly
AH4AK4_0263	COG0200	Binds to the 23S rRNA
AH4AK4_0264	COG0201	protein transport
AH4AK4_0266	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AH4AK4_0267	COG0202	RNA polymerase activity
AH4AK4_0268	COG0203	ribosomal protein L17
AH4AK4_0273	COG2249	NAD(P)H dehydrogenase (quinone) activity
AH4AK4_0274	COG0583	DNA-binding transcription factor activity
AH4AK4_0275	COG4221	oxidoreductase activity
AH4AK4_0278	COG1770	oligopeptidase
AH4AK4_0284	COG3714	YhhN family
AH4AK4_0289	COG1301	dicarboxylic acid transport
AH4AK4_0291	COG2095	MarC family integral membrane protein
AH4AK4_0293	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_0295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AH4AK4_0297	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AH4AK4_0302	COG0742	ribosomal rna small subunit methyltransferase
AH4AK4_0303	COG0552	protein localization to endoplasmic reticulum
AH4AK4_0304	COG2884	Cell division ATP-binding protein ftsE
AH4AK4_0305	COG2177	Part of the ABC transporter FtsEX involved in
AH4AK4_0307	COG0288	reversible hydration of carbon dioxide
AH4AK4_0308	COG2188	Transcriptional regulator
AH4AK4_0309	COG1228	amidohydrolase
AH4AK4_0310	COG0010	Belongs to the arginase family
AH4AK4_0311	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AH4AK4_0313	COG0387	Pfam Sodium calcium exchanger
AH4AK4_0314	COG2200	EAL domain
AH4AK4_0326	COG1459	type II secretion system
AH4AK4_0329	COG4968	Prepilin-type N-terminal cleavage methylation domain
AH4AK4_0334	COG1077	Cell shape determining protein MreB Mrl
AH4AK4_0335	COG1792	Involved in formation and maintenance of cell shape
AH4AK4_0336	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AH4AK4_0337	COG0424	maF-like protein
AH4AK4_0338	COG1530	ribonuclease E activity
AH4AK4_0339	COG3164	Protein of unknown function
AH4AK4_0340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_0341	COG0312	modulator of DNA gyrase
AH4AK4_0344	COG0477	Major facilitator Superfamily
AH4AK4_0346	COG2321	neutral zinc metallopeptidase
AH4AK4_0353	COG0189	ligase activity
AH4AK4_0355	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0359	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AH4AK4_0360	COG0352	thiamine-phosphate diphosphorylase activity
AH4AK4_0361	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AH4AK4_0363	COG2022	thiamine diphosphate biosynthetic process
AH4AK4_0364	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AH4AK4_0366	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_0367	COG0110	maltose O-acetyltransferase activity
AH4AK4_0370	COG3706	GGDEF domain
AH4AK4_0371	COG3932	Exopolysaccharide synthesis, ExoD
AH4AK4_0374	COG1733	regulation of RNA biosynthetic process
AH4AK4_0379	COG0456	acetyltransferase
AH4AK4_0381	COG1494	fructose-1,6-bisphosphatase
AH4AK4_0383	COG3071	HemY protein
AH4AK4_0384	COG2959	enzyme of heme biosynthesis
AH4AK4_0386	COG0181	hydroxymethylbilane synthase activity
AH4AK4_0388	COG3072	Adenylate cyclase
AH4AK4_0389	COG0400	carboxylic ester hydrolase activity
AH4AK4_0390	COG1965	Belongs to the frataxin family
AH4AK4_0392	COG0019	diaminopimelate decarboxylase activity
AH4AK4_0393	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AH4AK4_0396	COG1011	Hydrolase
AH4AK4_0398	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AH4AK4_0399	COG0561	phosphatase activity
AH4AK4_0401	COG1988	membrane-bound metal-dependent
AH4AK4_0402	COG1058	Belongs to the CinA family
AH4AK4_0402	COG1546	Belongs to the CinA family
AH4AK4_0404	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AH4AK4_0406	COG1522	sequence-specific DNA binding
AH4AK4_0407	COG1368	sulfuric ester hydrolase activity
AH4AK4_0410	COG1285	pathogenesis
AH4AK4_0414	COG4221	oxidoreductase activity
AH4AK4_0418	COG1979	alcohol dehydrogenase
AH4AK4_0420	COG2873	o-acetylhomoserine
AH4AK4_0425	COG5380	lipid catabolic process
AH4AK4_0426	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AH4AK4_0428	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AH4AK4_0429	COG2949	membrane
AH4AK4_0430	COG3291	Pkd domain containing protein
AH4AK4_0432	COG1441	menaquinone biosynthetic process
AH4AK4_0433	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AH4AK4_0434	COG0596	Alpha beta hydrolase
AH4AK4_0435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AH4AK4_0436	COG1169	isochorismate synthase
AH4AK4_0437	COG1575	Belongs to the MenA family. Type 1 subfamily
AH4AK4_0438	COG1966	Carbon starvation protein
AH4AK4_0439	COG2879	small protein
AH4AK4_0440	COG0523	cobalamin synthesis protein
AH4AK4_0445	COG0513	Belongs to the DEAD box helicase family
AH4AK4_0447	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_0448	COG5492	domain, Protein
AH4AK4_0448	COG4932	domain protein
AH4AK4_0450	COG1671	Belongs to the UPF0178 family
AH4AK4_0455	COG3722	fumarate hydratase activity
AH4AK4_0456	COG0246	Mannitol dehydrogenase
AH4AK4_0457	COG2213	PTS system mannitol-specific
AH4AK4_0457	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_0459	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AH4AK4_0462	COG2771	luxR family
AH4AK4_0465	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_0467	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AH4AK4_0467	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AH4AK4_0468	COG1538	Outer membrane efflux protein
AH4AK4_0469	COG0494	nUDIX hydrolase
AH4AK4_0470	COG3151	Protein conserved in bacteria
AH4AK4_0472	COG3150	esterase
AH4AK4_0473	COG1051	belongs to the nudix hydrolase family
AH4AK4_0476	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_0477	COG1289	transmembrane transporter activity
AH4AK4_0479	COG0187	DNA topoisomerase II activity
AH4AK4_0491	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_0496	COG0204	Acyl-transferase
AH4AK4_0497	COG1842	Phage shock protein A
AH4AK4_0500	COG2827	Endonuclease containing a URI domain
AH4AK4_0502	COG1573	uracil-dna glycosylase
AH4AK4_0504	COG0583	DNA-binding transcription factor activity
AH4AK4_0505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AH4AK4_0506	COG1121	(ABC) transporter
AH4AK4_0507	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AH4AK4_0511	COG0739	heme binding
AH4AK4_0517	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AH4AK4_0519	COG1546	Belongs to the CinA family
AH4AK4_0520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AH4AK4_0522	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AH4AK4_0523	COG0527	aspartate kinase activity
AH4AK4_0524	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AH4AK4_0531	COG1686	Belongs to the peptidase S11 family
AH4AK4_0532	COG0586	Pfam SNARE associated Golgi protein
AH4AK4_0533	COG1253	flavin adenine dinucleotide binding
AH4AK4_0534	COG0525	valine-tRNA ligase activity
AH4AK4_0535	COG2927	DNA polymerase III (CHI subunit)
AH4AK4_0536	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_0537	COG0795	lipopolysaccharide-transporting ATPase activity
AH4AK4_0538	COG0795	lipopolysaccharide-transporting ATPase activity
AH4AK4_0541	COG0004	ammonium transporteR
AH4AK4_0542	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_0547	COG0084	hydrolase, TatD family'
AH4AK4_0548	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_0550	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AH4AK4_0551	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AH4AK4_0552	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AH4AK4_0553	COG0813	purine-nucleoside phosphorylase activity
AH4AK4_0555	COG3064	Membrane
AH4AK4_0557	COG0560	Phosphoserine phosphatase
AH4AK4_0560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AH4AK4_0562	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AH4AK4_0563	COG0776	regulation of translation
AH4AK4_0566	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_0567	COG0735	belongs to the Fur family
AH4AK4_0571	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AH4AK4_0572	COG0513	Belongs to the DEAD box helicase family
AH4AK4_0573	COG3022	response to hydroperoxide
AH4AK4_0576	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AH4AK4_0577	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AH4AK4_0578	COG0762	integral membrane protein
AH4AK4_0579	COG1872	DUF167
AH4AK4_0583	COG3112	Uncharacterised protein family (UPF0231)
AH4AK4_0584	COG3835	regulator
AH4AK4_0585	COG2610	gluconate transmembrane transporter activity
AH4AK4_0586	COG1929	Belongs to the glycerate kinase type-1 family
AH4AK4_0589	COG0583	DNA-binding transcription factor activity
AH4AK4_0590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_0593	COG0347	Belongs to the P(II) protein family
AH4AK4_0594	COG1840	ABC-type Fe3 transport system, periplasmic component
AH4AK4_0596	COG3842	ATPase activity
AH4AK4_0597	COG2837	iron assimilation
AH4AK4_0598	COG1438	arginine binding
AH4AK4_0599	COG1126	abc transporter atp-binding protein
AH4AK4_0600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_0601	COG4215	(ABC) transporter
AH4AK4_0603	COG4160	amino acid transport
AH4AK4_0604	COG0039	L-malate dehydrogenase activity
AH4AK4_0605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AH4AK4_0606	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_0606	COG1017	nitric oxide dioxygenase activity
AH4AK4_0608	COG4536	flavin adenine dinucleotide binding
AH4AK4_0609	COG4137	Cytochrome C assembly protein
AH4AK4_0610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AH4AK4_0611	COG0228	four-way junction DNA binding
AH4AK4_0612	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AH4AK4_0613	COG0336	Belongs to the RNA methyltransferase TrmD family
AH4AK4_0614	COG0335	large ribosomal subunit rRNA binding
AH4AK4_0617	COG1051	belongs to the nudix hydrolase family
AH4AK4_0619	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AH4AK4_0620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AH4AK4_0621	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_0623	COG0583	DNA-binding transcription factor activity
AH4AK4_0624	COG0640	Transcriptional regulator
AH4AK4_0625	COG0268	Binds directly to 16S ribosomal RNA
AH4AK4_0626	COG0728	peptidoglycan biosynthetic process
AH4AK4_0627	COG0196	riboflavin kinase activity
AH4AK4_0628	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AH4AK4_0629	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AH4AK4_0630	COG1047	Peptidyl-prolyl cis-trans
AH4AK4_0631	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AH4AK4_0632	COG4968	Prepilin-type N-terminal cleavage methylation domain
AH4AK4_0638	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AH4AK4_0638	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_0641	COG1854	S-ribosylhomocysteine lyase activity
AH4AK4_0642	COG3706	GGDEF domain
AH4AK4_0643	COG0557	exoribonuclease II activity
AH4AK4_0644	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH4AK4_0646	COG2153	protein acetylation
AH4AK4_0648	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AH4AK4_0649	COG1914	H( )-stimulated, divalent metal cation uptake system
AH4AK4_0650	COG0360	Binds together with S18 to 16S ribosomal RNA
AH4AK4_0651	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AH4AK4_0652	COG0359	binds to the 23S rRNA
AH4AK4_0658	COG1064	alcohol dehydrogenase
AH4AK4_0659	COG1238	metal cluster binding
AH4AK4_0660	COG0612	Peptidase, M16
AH4AK4_0661	COG2918	glutathione biosynthetic process
AH4AK4_0662	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AH4AK4_0663	COG1027	Aspartate ammonia-lyase
AH4AK4_0664	COG3030	protein affecting phage T7 exclusion by the F plasmid
AH4AK4_0666	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AH4AK4_0667	COG0459	protein refolding
AH4AK4_0671	COG0564	pseudouridine synthase activity
AH4AK4_0672	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AH4AK4_0678	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AH4AK4_0680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AH4AK4_0681	COG4208	sulfate ABC transporter
AH4AK4_0682	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AH4AK4_0683	COG0583	DNA-binding transcription factor activity
AH4AK4_0685	COG3397	chitin binding
AH4AK4_0692	COG1328	CTP reductase activity
AH4AK4_0693	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH4AK4_0696	COG1448	Aminotransferase
AH4AK4_0697	COG2194	sulfuric ester hydrolase activity
AH4AK4_0701	COG1215	transferase activity, transferring glycosyl groups
AH4AK4_0703	COG3118	belongs to the thioredoxin family
AH4AK4_0703	COG0457	Tetratricopeptide repeat
AH4AK4_0710	COG0513	Belongs to the DEAD box helicase family
AH4AK4_0713	COG0840	transmembrane signaling receptor activity
AH4AK4_0715	COG4166	transmembrane transport
AH4AK4_0717	COG0110	maltose O-acetyltransferase activity
AH4AK4_0719	COG1024	Enoyl-CoA hydratase
AH4AK4_0722	COG4221	oxidoreductase activity
AH4AK4_0723	COG0442	prolyl-tRNA aminoacylation
AH4AK4_0724	COG0840	transmembrane signaling receptor activity
AH4AK4_0725	COG0632	four-way junction helicase activity
AH4AK4_0726	COG2255	four-way junction helicase activity
AH4AK4_0727	COG1271	oxidase subunit
AH4AK4_0728	COG1294	oxidase, subunit
AH4AK4_0729	COG4890	Cyd operon protein YbgT
AH4AK4_0730	COG3790	cyd operon protein YbgE
AH4AK4_0731	COG0824	Thioesterase
AH4AK4_0732	COG0811	peptide transport
AH4AK4_0735	COG0823	Involved in the tonB-independent uptake of proteins
AH4AK4_0736	COG2885	chlorophyll binding
AH4AK4_0737	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AH4AK4_0742	COG0840	transmembrane signaling receptor activity
AH4AK4_0743	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AH4AK4_0745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_0746	COG1640	4-alpha-glucanotransferase
AH4AK4_0747	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AH4AK4_0752	COG2130	NADP-dependent
AH4AK4_0753	COG1846	Transcriptional regulator
AH4AK4_0756	COG1522	sequence-specific DNA binding
AH4AK4_0760	COG0561	phosphatase activity
AH4AK4_0763	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_0764	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_0767	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_0770	COG1794	racemase activity, acting on amino acids and derivatives
AH4AK4_0772	COG1022	Amp-dependent synthetase and ligase
AH4AK4_0774	COG0456	acetyltransferase
AH4AK4_0777	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AH4AK4_0778	COG5001	Diguanylate cyclase
AH4AK4_0778	COG3300	MHYT domain
AH4AK4_0779	COG3706	GGDEF domain
AH4AK4_0779	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AH4AK4_0784	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_0789	COG2957	Belongs to the agmatine deiminase family
AH4AK4_0790	COG0154	amidase activity
AH4AK4_0797	COG0513	Belongs to the DEAD box helicase family
AH4AK4_0798	COG2203	Gaf domain
AH4AK4_0798	COG2199	diguanylate cyclase activity
AH4AK4_0805	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AH4AK4_0816	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AH4AK4_0817	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_0820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_0826	COG0745	RESPONSE REGULATOR receiver
AH4AK4_0827	COG3104	oligopeptide transport
AH4AK4_0828	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AH4AK4_0829	COG1555	photosystem II stabilization
AH4AK4_0831	COG2350	Protein conserved in bacteria
AH4AK4_0832	COG2917	probably involved in intracellular septation
AH4AK4_0833	COG0076	glutamate decarboxylase activity
AH4AK4_0835	COG1272	protein, Hemolysin III
AH4AK4_0836	COG0569	domain protein
AH4AK4_0836	COG2985	domain, Protein
AH4AK4_0838	COG0477	Major facilitator Superfamily
AH4AK4_0839	COG0583	DNA-binding transcription factor activity
AH4AK4_0841	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_0842	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_0844	COG2731	YhcH YjgK YiaL family protein
AH4AK4_0846	COG0668	transmembrane transport
AH4AK4_0847	COG1376	ErfK ybiS ycfS ynhG family protein
AH4AK4_0848	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AH4AK4_0851	COG0789	Transcriptional regulator
AH4AK4_0855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AH4AK4_0857	COG0488	(ABC) transporter
AH4AK4_0858	COG0516	GMP reductase activity
AH4AK4_0858	COG0517	IMP dehydrogenase activity
AH4AK4_0859	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AH4AK4_0860	COG0835	chemotaxis
AH4AK4_0860	COG0784	Response regulator, receiver
AH4AK4_0861	COG2755	lipolytic protein G-D-S-L family
AH4AK4_0862	COG4181	ATPase activity
AH4AK4_0863	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AH4AK4_0864	COG1090	epimerase
AH4AK4_0865	COG2200	EAL domain
AH4AK4_0866	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_0867	COG2234	aminopeptidase activity
AH4AK4_0867	COG4935	Belongs to the peptidase S8 family
AH4AK4_0868	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AH4AK4_0869	COG3171	Protein conserved in bacteria
AH4AK4_0870	COG2066	Belongs to the glutaminase family
AH4AK4_0871	COG2897	thiosulfate sulfurtransferase activity
AH4AK4_0872	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_0883	COG1132	(ABC) transporter
AH4AK4_0889	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AH4AK4_0890	COG3300	MHYT domain
AH4AK4_0890	COG5001	Diguanylate cyclase
AH4AK4_0894	COG4628	conserved protein (DUF2132)
AH4AK4_0895	COG0688	phosphatidylethanolamine metabolic process
AH4AK4_0897	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AH4AK4_0903	COG1278	Cold shock
AH4AK4_0905	COG0840	transmembrane signaling receptor activity
AH4AK4_0907	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_0918	COG0848	biopolymer transport protein
AH4AK4_0919	COG0811	peptide transport
AH4AK4_0920	COG0811	peptide transport
AH4AK4_0922	COG4206	TonB-dependent receptor
AH4AK4_0925	COG4174	ABC transporter (Permease)
AH4AK4_0926	COG4239	(ABC) transporter, permease
AH4AK4_0928	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_0929	COG4608	Belongs to the ABC transporter superfamily
AH4AK4_0931	COG2195	Cleaves the N-terminal amino acid of tripeptides
AH4AK4_0933	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AH4AK4_0938	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AH4AK4_0943	COG0243	molybdopterin cofactor binding
AH4AK4_0946	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AH4AK4_0946	COG1116	anion transmembrane transporter activity
AH4AK4_0947	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_0948	COG1116	anion transmembrane transporter activity
AH4AK4_0949	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_0949	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_0950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_0950	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_0952	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_0953	COG2313	pseudouridylate synthase activity
AH4AK4_0955	COG1858	cytochrome C peroxidase
AH4AK4_0958	COG0521	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_0961	COG2966	Psort location CytoplasmicMembrane, score
AH4AK4_0962	COG3610	response to peptide
AH4AK4_0964	COG4175	Glycine betaine
AH4AK4_0965	COG4176	ABC-type proline glycine betaine transport system permease component
AH4AK4_0966	COG2113	Glycine betaine
AH4AK4_0967	COG0175	sulfate reduction
AH4AK4_0968	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_0970	COG0384	phenazine biosynthesis protein PhzF
AH4AK4_0971	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AH4AK4_0972	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AH4AK4_0974	COG0786	glutamate:sodium symporter activity
AH4AK4_0975	COG0252	asparaginase activity
AH4AK4_0976	COG3139	Protein of unknown function (DUF1315)
AH4AK4_0980	COG0616	signal peptide processing
AH4AK4_0981	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_0981	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_0982	COG0778	Nitroreductase
AH4AK4_0984	COG2264	protein methyltransferase activity
AH4AK4_0985	COG0604	alcohol dehydrogenase
AH4AK4_0986	COG0583	DNA-binding transcription factor activity
AH4AK4_0987	COG1263	PTS System
AH4AK4_0987	COG2190	(PTS) system
AH4AK4_0987	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_0988	COG4145	pantothenate transmembrane transporter activity
AH4AK4_0989	COG3924	membrane
AH4AK4_0990	COG0439	Biotin carboxylase
AH4AK4_0991	COG0511	ligase activity, forming carbon-carbon bonds
AH4AK4_0992	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AH4AK4_0993	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AH4AK4_0996	COG3381	protein complex oligomerization
AH4AK4_0998	COG3005	denitrification pathway
AH4AK4_0999	COG0745	RESPONSE REGULATOR receiver
AH4AK4_1000	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_1001	COG0784	Response regulator, receiver
AH4AK4_1001	COG2198	Histidine kinase
AH4AK4_1001	COG2205	protein histidine kinase activity
AH4AK4_1003	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AH4AK4_1004	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AH4AK4_1005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AH4AK4_1005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AH4AK4_1008	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AH4AK4_1009	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_1010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AH4AK4_1011	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AH4AK4_1017	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AH4AK4_1018	COG0142	geranyltranstransferase activity
AH4AK4_1019	COG1722	exodeoxyribonuclease VII activity
AH4AK4_1020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_1021	COG1360	Flagellar Motor Protein
AH4AK4_1022	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_1023	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AH4AK4_1024	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AH4AK4_1034	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AH4AK4_1036	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH4AK4_1038	COG1534	Rna-binding protein
AH4AK4_1039	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AH4AK4_1040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AH4AK4_1041	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AH4AK4_1042	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AH4AK4_1043	COG0149	triose-phosphate isomerase activity
AH4AK4_1044	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AH4AK4_1047	COG0779	Required for maturation of 30S ribosomal subunits
AH4AK4_1048	COG0195	Participates in both transcription termination and antitermination
AH4AK4_1049	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AH4AK4_1050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AH4AK4_1051	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AH4AK4_1052	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AH4AK4_1053	COG1185	polyribonucleotide nucleotidyltransferase activity
AH4AK4_1054	COG2211	Major facilitator Superfamily
AH4AK4_1055	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AH4AK4_1057	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AH4AK4_1061	COG0312	modulator of DNA gyrase
AH4AK4_1064	COG0716	FMN binding
AH4AK4_1065	COG0716	FMN binding
AH4AK4_1066	COG4974	Belongs to the 'phage' integrase family
AH4AK4_1067	COG1970	mechanosensitive ion channel activity
AH4AK4_1069	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AH4AK4_1071	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_1073	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AH4AK4_1075	COG0321	lipoyl(octanoyl) transferase activity
AH4AK4_1076	COG2921	Belongs to the UPF0250 family
AH4AK4_1077	COG1686	Belongs to the peptidase S11 family
AH4AK4_1078	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AH4AK4_1079	COG2951	lytic endotransglycosylase activity
AH4AK4_1080	COG0772	Belongs to the SEDS family
AH4AK4_1081	COG0768	penicillin binding
AH4AK4_1082	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AH4AK4_1083	COG0799	negative regulation of ribosome biogenesis
AH4AK4_1084	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AH4AK4_1087	COG0495	leucyl-tRNA aminoacylation
AH4AK4_1088	COG2888	peptidyl-tyrosine sulfation
AH4AK4_1089	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AH4AK4_1090	COG4535	Mg2 and Co2 transporter CorC
AH4AK4_1091	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AH4AK4_1092	COG1702	phosphate starvation-inducible protein PhoH
AH4AK4_1093	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AH4AK4_1094	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_1095	COG1335	isochorismatase
AH4AK4_1096	COG0583	DNA-binding transcription factor activity
AH4AK4_1098	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_1100	COG3706	GGDEF domain
AH4AK4_1102	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AH4AK4_1104	COG3647	Membrane
AH4AK4_1105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AH4AK4_1107	COG0516	GMP reductase activity
AH4AK4_1109	COG0642	Histidine kinase
AH4AK4_1110	COG0745	RESPONSE REGULATOR receiver
AH4AK4_1112	COG0300	oxidoreductase activity
AH4AK4_1114	COG1022	Amp-dependent synthetase and ligase
AH4AK4_1116	COG4106	trans-aconitate 2-methyltransferase activity
AH4AK4_1117	COG3214	Protein conserved in bacteria
AH4AK4_1118	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AH4AK4_1119	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AH4AK4_1120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AH4AK4_1121	COG1053	succinate dehydrogenase
AH4AK4_1124	COG0584	glycerophosphoryl diester phosphodiesterase
AH4AK4_1126	COG3264	Mechanosensitive ion channel
AH4AK4_1126	COG1511	domain protein
AH4AK4_1128	COG0739	heme binding
AH4AK4_1131	COG3121	Chaperone
AH4AK4_1132	COG3188	usher protein
AH4AK4_1133	COG3121	Chaperone
AH4AK4_1136	COG0583	DNA-binding transcription factor activity
AH4AK4_1139	COG0583	DNA-binding transcription factor activity
AH4AK4_1140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AH4AK4_1146	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AH4AK4_1147	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AH4AK4_1149	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AH4AK4_1150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AH4AK4_1152	COG0180	Tryptophanyl-tRNA synthetase
AH4AK4_1155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AH4AK4_1157	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_1159	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_1162	COG0488	(ABC) transporter
AH4AK4_1164	COG0366	Alpha amylase catalytic
AH4AK4_1168	COG0471	metal ion transport
AH4AK4_1168	COG0490	domain, Protein
AH4AK4_1177	COG0012	GTP binding
AH4AK4_1178	COG0193	aminoacyl-tRNA hydrolase activity
AH4AK4_1179	COG0737	Belongs to the 5'-nucleotidase family
AH4AK4_1180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AH4AK4_1183	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AH4AK4_1184	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AH4AK4_1185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AH4AK4_1186	COG2890	protein-(glutamine-N5) methyltransferase activity
AH4AK4_1188	COG2912	Transglutaminase-like superfamily
AH4AK4_1190	COG1301	dicarboxylic acid transport
AH4AK4_1192	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AH4AK4_1195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AH4AK4_1196	COG1115	amino acid carrier protein
AH4AK4_1200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AH4AK4_1201	COG1678	Uncharacterized ACR, COG1678
AH4AK4_1202	COG0189	ligase activity
AH4AK4_1203	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AH4AK4_1205	COG3091	SprT-like family
AH4AK4_1207	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AH4AK4_1212	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AH4AK4_1214	COG0739	heme binding
AH4AK4_1215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AH4AK4_1216	COG3408	Glycogen debranching enzyme
AH4AK4_1216	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AH4AK4_1218	COG1881	PFAM PEBP family protein
AH4AK4_1220	COG0583	DNA-binding transcription factor activity
AH4AK4_1222	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AH4AK4_1224	COG0583	DNA-binding transcription factor activity
AH4AK4_1225	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_1226	COG0616	signal peptide processing
AH4AK4_1227	COG3724	N-succinylarginine dihydrolase activity
AH4AK4_1228	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AH4AK4_1231	COG0840	transmembrane signaling receptor activity
AH4AK4_1233	COG2971	BadF BadG BcrA BcrD
AH4AK4_1236	COG4608	Belongs to the ABC transporter superfamily
AH4AK4_1237	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_1238	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_1242	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AH4AK4_1246	COG1677	Flagellar hook-basal body complex protein FliE
AH4AK4_1248	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AH4AK4_1258	COG1987	bacterial-type flagellum assembly
AH4AK4_1259	COG1684	flagellar biosynthetic protein fliR
AH4AK4_1262	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AH4AK4_1264	COG0455	bacterial-type flagellum organization
AH4AK4_1267	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AH4AK4_1268	COG2198	Histidine kinase
AH4AK4_1268	COG0643	Histidine kinase
AH4AK4_1269	COG2201	protein-glutamate methylesterase activity
AH4AK4_1270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_1271	COG1360	Flagellar Motor Protein
AH4AK4_1272	COG1192	Involved in chromosome partitioning
AH4AK4_1274	COG0835	chemotaxis
AH4AK4_1277	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_1279	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_1280	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_1281	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AH4AK4_1282	COG1138	Cytochrome C-type biogenesis protein
AH4AK4_1283	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_1284	COG3088	subunit of a heme lyase
AH4AK4_1284	COG4235	cytochrome complex assembly
AH4AK4_1285	COG0457	Tetratricopeptide repeat
AH4AK4_1288	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AH4AK4_1289	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_1289	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_1292	COG0259	pyridoxamine-phosphate oxidase activity
AH4AK4_1298	COG3153	acetyltransferase
AH4AK4_1301	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AH4AK4_1302	COG2867	negative regulation of translational initiation
AH4AK4_1304	COG0702	epimerase
AH4AK4_1305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_1306	COG1454	alcohol dehydrogenase
AH4AK4_1314	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_1316	COG3263	regulation of cellular component size
AH4AK4_1318	COG1876	peptidase activity
AH4AK4_1319	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH4AK4_1320	COG1393	Belongs to the ArsC family
AH4AK4_1323	COG3069	C4-dicarboxylate transmembrane transporter activity
AH4AK4_1324	COG1473	amidohydrolase
AH4AK4_1326	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AH4AK4_1328	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_1329	COG4221	oxidoreductase activity
AH4AK4_1331	COG0017	Asparaginyl-tRNA synthetase
AH4AK4_1336	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AH4AK4_1337	COG0156	8-amino-7-oxononanoate synthase activity
AH4AK4_1338	COG2226	methyltransferase
AH4AK4_1338	COG1073	alpha beta
AH4AK4_1339	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AH4AK4_1340	COG0501	Belongs to the peptidase M48B family
AH4AK4_1341	COG0633	Ferredoxin
AH4AK4_1341	COG3217	Mosc domain protein beta barrel domain protein
AH4AK4_1341	COG0633	Ferredoxin
AH4AK4_1341	COG3217	Mosc domain protein beta barrel domain protein
AH4AK4_1343	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AH4AK4_1343	COG1013	pyruvate-flavodoxin oxidoreductase activity
AH4AK4_1343	COG0674	pyruvate-flavodoxin oxidoreductase activity
AH4AK4_1343	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AH4AK4_1344	COG2841	Protein conserved in bacteria
AH4AK4_1346	COG0534	Mate efflux family protein
AH4AK4_1353	COG1309	transcriptional regulator
AH4AK4_1356	COG0791	NLP P60 protein
AH4AK4_1357	COG0583	DNA-binding transcription factor activity
AH4AK4_1361	COG0500	methyltransferase
AH4AK4_1362	COG4106	trans-aconitate 2-methyltransferase activity
AH4AK4_1363	COG1801	Protein of unknown function DUF72
AH4AK4_1364	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AH4AK4_1365	COG0217	transcriptional regulatory protein
AH4AK4_1367	COG1846	Transcriptional regulator
AH4AK4_1367	COG1940	carbohydrate kinase activity
AH4AK4_1368	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AH4AK4_1369	COG0363	glucosamine-6-phosphate deaminase activity
AH4AK4_1370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_1370	COG2190	(PTS) system
AH4AK4_1370	COG1263	PTS System
AH4AK4_1374	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AH4AK4_1374	COG2010	Cytochrome c
AH4AK4_1376	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AH4AK4_1377	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_1378	COG0735	belongs to the Fur family
AH4AK4_1380	COG0716	FMN binding
AH4AK4_1383	COG0596	Alpha beta hydrolase
AH4AK4_1384	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AH4AK4_1385	COG0033	Phosphoglucomutase
AH4AK4_1388	COG2951	lytic endotransglycosylase activity
AH4AK4_1389	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH4AK4_1390	COG4136	ATPase activity
AH4AK4_1392	COG4134	Bacterial extracellular solute-binding protein
AH4AK4_1394	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AH4AK4_1396	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AH4AK4_1398	COG0729	surface antigen
AH4AK4_1399	COG2911	Protein conserved in bacteria
AH4AK4_1403	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AH4AK4_1405	COG0741	lytic transglycosylase activity
AH4AK4_1409	COG1607	acyl-coa hydrolase
AH4AK4_1411	COG3021	interspecies interaction between organisms
AH4AK4_1412	COG0741	lytic transglycosylase activity
AH4AK4_1412	COG1388	LysM domain
AH4AK4_1413	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AH4AK4_1414	COG2226	methyltransferase
AH4AK4_1415	COG0328	RNA-DNA hybrid ribonuclease activity
AH4AK4_1416	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AH4AK4_1418	COG3437	response regulator, receiver
AH4AK4_1418	COG0784	Response regulator, receiver
AH4AK4_1420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AH4AK4_1421	COG0121	glutamine amidotransferase
AH4AK4_1423	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AH4AK4_1428	COG2197	response regulator
AH4AK4_1429	COG3850	Histidine kinase
AH4AK4_1430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AH4AK4_1431	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AH4AK4_1433	COG0243	molybdopterin cofactor binding
AH4AK4_1434	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_1435	COG0348	domain, Protein
AH4AK4_1437	COG3005	denitrification pathway
AH4AK4_1438	COG0521	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_1439	COG0315	cyclic pyranopterin monophosphate synthase activity
AH4AK4_1440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AH4AK4_1441	COG0314	molybdopterin synthase activity
AH4AK4_1444	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AH4AK4_1445	COG2267	carboxylic ester hydrolase activity
AH4AK4_1448	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AH4AK4_1449	COG0303	'Molybdopterin
AH4AK4_1450	COG0302	gtp cyclohydrolase
AH4AK4_1451	COG0840	transmembrane signaling receptor activity
AH4AK4_1452	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AH4AK4_1454	COG0583	DNA-binding transcription factor activity
AH4AK4_1460	COG2195	Cleaves the N-terminal amino acid of tripeptides
AH4AK4_1463	COG1166	arginine decarboxylase activity
AH4AK4_1464	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AH4AK4_1466	COG1403	HNH endonuclease
AH4AK4_1469	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AH4AK4_1470	COG1187	pseudouridine synthase activity
AH4AK4_1471	COG2807	transmembrane transport
AH4AK4_1473	COG0583	DNA-binding transcription factor activity
AH4AK4_1479	COG2979	Protein of unknown function (DUF533)
AH4AK4_1481	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_1483	COG1294	oxidase, subunit
AH4AK4_1485	COG2814	Major facilitator Superfamily
AH4AK4_1487	COG0656	L-ascorbic acid biosynthetic process
AH4AK4_1491	COG0583	DNA-binding transcription factor activity
AH4AK4_1492	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AH4AK4_1493	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH4AK4_1494	COG2271	Major facilitator Superfamily
AH4AK4_1495	COG1349	DNA-binding transcription factor activity
AH4AK4_1498	COG0584	glycerophosphoryl diester phosphodiesterase
AH4AK4_1499	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_1500	COG0287	Prephenate dehydrogenase
AH4AK4_1500	COG1605	Chorismate mutase
AH4AK4_1502	COG3085	chromosome segregation
AH4AK4_1503	COG4574	serine-type endopeptidase inhibitor activity
AH4AK4_1507	COG1770	oligopeptidase
AH4AK4_1508	COG4206	TonB-dependent receptor
AH4AK4_1509	COG3083	sulfuric ester hydrolase activity
AH4AK4_1510	COG3082	Protein of unknown function (DUF1414)
AH4AK4_1511	COG3081	Nucleoid-associated protein
AH4AK4_1513	COG2182	Extracellular solute-binding protein
AH4AK4_1514	COG1175	transmembrane transport
AH4AK4_1516	COG3842	ATPase activity
AH4AK4_1521	COG0425	Belongs to the sulfur carrier protein TusA family
AH4AK4_1523	COG4783	chaperone-mediated protein folding
AH4AK4_1524	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_1525	COG1393	Belongs to the ArsC family
AH4AK4_1527	COG1228	amidohydrolase
AH4AK4_1529	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_1530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AH4AK4_1531	COG2431	L-lysine efflux transmembrane transporter activity
AH4AK4_1534	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_1535	COG4215	(ABC) transporter
AH4AK4_1536	COG4160	amino acid transport
AH4AK4_1538	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH4AK4_1540	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_1543	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_1546	COG2373	Large extracellular alpha-helical protein
AH4AK4_1547	COG4953	penicillin-binding protein 1C
AH4AK4_1549	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_1549	COG0301	tRNA thio-modification
AH4AK4_1552	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_1554	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_1555	COG1334	flagellar protein FlaG
AH4AK4_1561	COG2089	acid synthase
AH4AK4_1564	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AH4AK4_1565	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AH4AK4_1567	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AH4AK4_1568	COG1086	Polysaccharide biosynthesis protein
AH4AK4_1571	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AH4AK4_1574	COG0840	transmembrane signaling receptor activity
AH4AK4_1575	COG0346	lactoylglutathione lyase activity
AH4AK4_1576	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AH4AK4_1578	COG4659	FMN binding
AH4AK4_1580	COG4658	electron transport chain
AH4AK4_1581	COG4656	Part of a membrane complex involved in electron transport
AH4AK4_1582	COG2878	Part of a membrane complex involved in electron transport
AH4AK4_1583	COG4657	Part of a membrane complex involved in electron transport
AH4AK4_1584	COG0697	spore germination
AH4AK4_1589	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AH4AK4_1590	COG1288	antiporter activity
AH4AK4_1591	COG0436	Aminotransferase
AH4AK4_1594	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AH4AK4_1595	COG2027	D-alanyl-D-alanine carboxypeptidase
AH4AK4_1596	COG1061	Type III restriction enzyme res subunit
AH4AK4_1598	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_1600	COG3264	Mechanosensitive ion channel
AH4AK4_1600	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AH4AK4_1601	COG1966	Carbon starvation protein
AH4AK4_1602	COG3279	Response regulator of the LytR AlgR family
AH4AK4_1603	COG3275	phosphorelay sensor kinase activity
AH4AK4_1605	COG1454	alcohol dehydrogenase
AH4AK4_1605	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_1606	COG2095	MarC family integral membrane protein
AH4AK4_1608	COG0601	transmembrane transport
AH4AK4_1609	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_1610	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_1613	COG0861	Integral membrane protein TerC family
AH4AK4_1614	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH4AK4_1617	COG1301	dicarboxylic acid transport
AH4AK4_1620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AH4AK4_1623	COG0537	adenosine 5'-monophosphoramidase activity
AH4AK4_1631	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_1633	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_1636	COG2354	Protein conserved in bacteria
AH4AK4_1640	COG1252	NADH dehydrogenase
AH4AK4_1641	COG0393	Putative heavy-metal-binding
AH4AK4_1642	COG1368	sulfuric ester hydrolase activity
AH4AK4_1644	COG0527	aspartate kinase activity
AH4AK4_1646	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AH4AK4_1646	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AH4AK4_1648	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AH4AK4_1656	COG1136	(ABC) transporter
AH4AK4_1660	COG2814	Major facilitator Superfamily
AH4AK4_1664	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AH4AK4_1664	COG0493	'glutamate synthase
AH4AK4_1665	COG0672	)-iron permease
AH4AK4_1672	COG2308	Evidence 4 Homologs of previously reported genes of
AH4AK4_1675	COG0659	secondary active sulfate transmembrane transporter activity
AH4AK4_1680	COG3501	Rhs element vgr protein
AH4AK4_1702	COG3501	Rhs element vgr protein
AH4AK4_1705	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AH4AK4_1706	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_1707	COG5557	Pfam Polysulphide reductase, NrfD
AH4AK4_1708	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AH4AK4_1709	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AH4AK4_1710	COG1773	rubredoxin
AH4AK4_1712	COG0601	transmembrane transport
AH4AK4_1713	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_1716	COG1124	(ABC) transporter
AH4AK4_1717	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AH4AK4_1720	COG0375	protein maturation
AH4AK4_1721	COG0309	Hydrogenase expression formation protein (HypE)
AH4AK4_1723	COG0298	carbon dioxide binding
AH4AK4_1724	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AH4AK4_1727	COG3158	transport of potassium into the cell
AH4AK4_1730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AH4AK4_1731	COG0326	Molecular chaperone. Has ATPase activity
AH4AK4_1732	COG0563	adenylate kinase activity
AH4AK4_1733	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AH4AK4_1736	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_1738	COG0840	transmembrane signaling receptor activity
AH4AK4_1742	COG3300	MHYT domain
AH4AK4_1742	COG5001	Diguanylate cyclase
AH4AK4_1743	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AH4AK4_1748	COG1021	2,3-dihydroxybenzoate-AMP ligase
AH4AK4_1749	COG3433	isochorismatase activity
AH4AK4_1749	COG1535	isochorismatase
AH4AK4_1750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AH4AK4_1751	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_1753	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AH4AK4_1754	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AH4AK4_1755	COG2977	Belongs to the P-Pant transferase superfamily
AH4AK4_1756	COG1120	ATPase activity
AH4AK4_1757	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_1758	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_1759	COG4771	TonB-dependent receptor
AH4AK4_1763	COG0598	Magnesium transport protein CorA
AH4AK4_1768	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AH4AK4_1769	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AH4AK4_1770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_1771	COG0861	Integral membrane protein TerC family
AH4AK4_1774	COG1022	Amp-dependent synthetase and ligase
AH4AK4_1775	COG0295	cytidine deaminase activity
AH4AK4_1776	COG1346	cytolysis
AH4AK4_1778	COG3345	alpha-galactosidase
AH4AK4_1780	COG2925	Exonuclease
AH4AK4_1781	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AH4AK4_1783	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_1784	COG0436	Aminotransferase
AH4AK4_1785	COG0583	DNA-binding transcription factor activity
AH4AK4_1786	COG2160	L-arabinose isomerase activity
AH4AK4_1788	COG1069	ribulokinase activity
AH4AK4_1789	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_1791	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_1793	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AH4AK4_1794	COG0254	rRNA binding
AH4AK4_1797	COG1451	nucleotide metabolic process
AH4AK4_1800	COG3069	C4-dicarboxylate transmembrane transporter activity
AH4AK4_1802	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_1802	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AH4AK4_1803	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AH4AK4_1807	COG2009	succinate dehydrogenase
AH4AK4_1808	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AH4AK4_1809	COG1053	succinate dehydrogenase
AH4AK4_1811	COG0567	Dehydrogenase, E1 component
AH4AK4_1812	COG0508	dehydrogenase complex catalyzes the overall conversion of
AH4AK4_1813	COG0045	succinate-CoA ligase (ADP-forming) activity
AH4AK4_1816	COG2983	Belongs to the UPF0260 family
AH4AK4_1817	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_1819	COG3842	ATPase activity
AH4AK4_1820	COG1840	ABC-type Fe3 transport system, periplasmic component
AH4AK4_1823	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AH4AK4_1825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_1826	COG1882	Formate acetyltransferase
AH4AK4_1827	COG2116	formate transmembrane transporter activity
AH4AK4_1828	COG1944	ATP diphosphatase activity
AH4AK4_1830	COG2076	Multidrug Resistance protein
AH4AK4_1831	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AH4AK4_1832	COG1278	Cold shock
AH4AK4_1833	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AH4AK4_1834	COG0542	response to heat
AH4AK4_1835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AH4AK4_1836	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AH4AK4_1837	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AH4AK4_1838	COG3134	Outer membrane lipoprotein
AH4AK4_1839	COG3706	GGDEF domain
AH4AK4_1840	COG0492	ferredoxin-NADP+ reductase activity
AH4AK4_1841	COG0686	Belongs to the AlaDH PNT family
AH4AK4_1844	COG0531	amino acid
AH4AK4_1844	COG1674	ftsk spoiiie
AH4AK4_1845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AH4AK4_1846	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AH4AK4_1848	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AH4AK4_1849	COG1286	toxin biosynthetic process
AH4AK4_1850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AH4AK4_1851	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_1852	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_1852	COG1263	PTS System
AH4AK4_1853	COG1609	Transcriptional regulator
AH4AK4_1855	COG4172	Belongs to the ABC transporter superfamily
AH4AK4_1859	COG4171	peptide transport system, permease
AH4AK4_1860	COG4168	peptide transport system, permease
AH4AK4_1862	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AH4AK4_1863	COG1842	Phage shock protein A
AH4AK4_1866	COG3106	COG3106 Predicted ATPase
AH4AK4_1867	COG3768	UPF0283 membrane protein
AH4AK4_1869	COG2154	pterin-4-alpha-carbinolamine dehydratase
AH4AK4_1872	COG2199	diguanylate cyclase activity
AH4AK4_1873	COG2885	chlorophyll binding
AH4AK4_1875	COG1570	exodeoxyribonuclease VII activity
AH4AK4_1880	COG0366	Alpha amylase catalytic
AH4AK4_1880	COG1874	Beta-galactosidase
AH4AK4_1883	COG0516	GMP reductase activity
AH4AK4_1883	COG0517	IMP dehydrogenase activity
AH4AK4_1884	COG0519	Catalyzes the synthesis of GMP from XMP
AH4AK4_1884	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AH4AK4_1892	COG2062	phosphohistidine phosphatase, SixA
AH4AK4_1894	COG0697	spore germination
AH4AK4_1895	COG4166	transmembrane transport
AH4AK4_1896	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AH4AK4_1897	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AH4AK4_1899	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH4AK4_1900	COG1136	(ABC) transporter
AH4AK4_1901	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH4AK4_1905	COG0544	peptidyl-prolyl cis-trans isomerase activity
AH4AK4_1906	COG0740	serine-type endopeptidase activity
AH4AK4_1907	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AH4AK4_1908	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AH4AK4_1909	COG0776	regulation of translation
AH4AK4_1910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AH4AK4_1911	COG0488	(ABC) transporter
AH4AK4_1912	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AH4AK4_1913	COG3162	membrane
AH4AK4_1916	COG1024	Enoyl-CoA hydratase
AH4AK4_1917	COG1115	amino acid carrier protein
AH4AK4_1920	COG1584	GPR1 FUN34 yaaH family protein
AH4AK4_1925	COG1024	Enoyl-CoA hydratase
AH4AK4_1926	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AH4AK4_1927	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_1929	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_1930	COG1024	Enoyl-CoA hydratase
AH4AK4_1931	COG1024	Enoyl-CoA hydratase
AH4AK4_1933	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_1935	COG0730	response to heat
AH4AK4_1937	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_1939	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_1940	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_1941	COG1129	ABC transporter
AH4AK4_1942	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_1946	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AH4AK4_1947	COG0243	molybdopterin cofactor binding
AH4AK4_1950	COG3706	GGDEF domain
AH4AK4_1951	COG0583	DNA-binding transcription factor activity
AH4AK4_1953	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_1954	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_1955	COG0583	DNA-binding transcription factor activity
AH4AK4_1959	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AH4AK4_1960	COG0673	inositol 2-dehydrogenase activity
AH4AK4_1961	COG0583	DNA-binding transcription factor activity
AH4AK4_1963	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_1965	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_1970	COG0417	DNA replication proofreading
AH4AK4_1976	COG0534	Mate efflux family protein
AH4AK4_1978	COG0307	riboflavin synthase, alpha
AH4AK4_1980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_1981	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AH4AK4_1982	COG0697	spore germination
AH4AK4_1983	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AH4AK4_1991	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH4AK4_1993	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AH4AK4_1994	COG2894	cell division
AH4AK4_1995	COG0850	regulation of cytokinetic process
AH4AK4_1996	COG3100	YcgL domain-containing protein
AH4AK4_1997	COG2951	lytic endotransglycosylase activity
AH4AK4_1998	COG1760	l-serine dehydratase
AH4AK4_1999	COG1760	l-serine dehydratase
AH4AK4_2001	COG3123	guanosine phosphorylase activity
AH4AK4_2002	COG1301	dicarboxylic acid transport
AH4AK4_2005	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AH4AK4_2006	COG2067	long-chain fatty acid transport protein
AH4AK4_2007	COG2067	long-chain fatty acid transport protein
AH4AK4_2010	COG1595	DNA-templated transcription, initiation
AH4AK4_2012	COG2304	oxidoreductase activity
AH4AK4_2017	COG0714	Associated with various cellular activities
AH4AK4_2018	COG0183	Belongs to the thiolase family
AH4AK4_2019	COG1250	3-hydroxyacyl-CoA dehydrogenase
AH4AK4_2019	COG1024	Enoyl-CoA hydratase
AH4AK4_2021	COG4681	YaeQ
AH4AK4_2026	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_2030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_2033	COG3710	Transcriptional regulator
AH4AK4_2033	COG0457	Tetratricopeptide repeat
AH4AK4_2034	COG3134	Outer membrane lipoprotein
AH4AK4_2036	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_2039	COG0140	phosphoribosyl-ATP diphosphatase activity
AH4AK4_2039	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AH4AK4_2040	COG0107	imidazoleglycerol-phosphate synthase activity
AH4AK4_2041	COG2205	protein histidine kinase activity
AH4AK4_2041	COG2198	Histidine kinase
AH4AK4_2041	COG0784	Response regulator, receiver
AH4AK4_2043	COG3437	response regulator, receiver
AH4AK4_2044	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AH4AK4_2045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AH4AK4_2046	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AH4AK4_2046	COG0131	Imidazoleglycerol-phosphate dehydratase
AH4AK4_2047	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AH4AK4_2048	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AH4AK4_2049	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AH4AK4_2051	COG1199	ATP-dependent helicase activity
AH4AK4_2052	COG1214	PFAM Peptidase M22, glycoprotease
AH4AK4_2054	COG0596	Alpha beta hydrolase
AH4AK4_2055	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_2058	COG0697	spore germination
AH4AK4_2060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_2061	COG2832	Protein of unknown function (DUF454)
AH4AK4_2062	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AH4AK4_2065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AH4AK4_2066	COG1335	isochorismatase
AH4AK4_2070	COG2197	response regulator
AH4AK4_2072	COG1643	Atp-dependent helicase
AH4AK4_2074	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AH4AK4_2077	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AH4AK4_2078	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AH4AK4_2079	COG0709	Synthesizes selenophosphate from selenide and ATP
AH4AK4_2082	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AH4AK4_2083	COG0840	transmembrane signaling receptor activity
AH4AK4_2084	COG1254	Belongs to the acylphosphatase family
AH4AK4_2086	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_2086	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_2087	COG0489	protein tyrosine kinase activity
AH4AK4_2088	COG0572	uridine kinase
AH4AK4_2089	COG0717	Belongs to the dCTP deaminase family
AH4AK4_2090	COG0306	phosphate transporter
AH4AK4_2091	COG1530	ribonuclease E activity
AH4AK4_2093	COG0424	maF-like protein
AH4AK4_2095	COG1399	metal-binding, possibly nucleic acid-binding protein
AH4AK4_2096	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AH4AK4_2097	COG0416	fatty acid biosynthetic process
AH4AK4_2098	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AH4AK4_2100	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_2101	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AH4AK4_2103	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AH4AK4_2104	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AH4AK4_2105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AH4AK4_2106	COG0470	DNA polymerase III
AH4AK4_2107	COG0084	hydrolase, TatD family'
AH4AK4_2110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_2110	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AH4AK4_2111	COG3008	intermembrane lipid transfer
AH4AK4_2112	COG2995	paraquat-inducible protein a
AH4AK4_2114	COG3141	response to X-ray
AH4AK4_2116	COG1067	ATP-dependent peptidase activity
AH4AK4_2117	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AH4AK4_2122	COG0116	Belongs to the methyltransferase superfamily
AH4AK4_2122	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AH4AK4_2124	COG0167	dihydroorotate dehydrogenase activity
AH4AK4_2125	COG2902	Dehydrogenase
AH4AK4_2127	COG0308	aminopeptidase N
AH4AK4_2130	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AH4AK4_2131	COG1956	GAF domain-containing protein
AH4AK4_2133	COG3278	Belongs to the heme-copper respiratory oxidase family
AH4AK4_2136	COG2010	Cytochrome c
AH4AK4_2141	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH4AK4_2142	COG0589	response to stress
AH4AK4_2143	COG0037	tRNA processing
AH4AK4_2147	COG1869	D-ribose catabolic process
AH4AK4_2148	COG1129	ABC transporter
AH4AK4_2149	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_2150	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_2151	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_2152	COG1609	Transcriptional regulator
AH4AK4_2153	COG5001	Diguanylate cyclase
AH4AK4_2153	COG3300	MHYT domain
AH4AK4_2155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AH4AK4_2158	COG0784	Response regulator, receiver
AH4AK4_2158	COG2205	protein histidine kinase activity
AH4AK4_2159	COG0776	regulation of translation
AH4AK4_2160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_2160	COG0072	phenylalanine-tRNA ligase activity
AH4AK4_2161	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AH4AK4_2162	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AH4AK4_2163	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AH4AK4_2164	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AH4AK4_2171	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AH4AK4_2173	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH4AK4_2174	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH4AK4_2175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_2176	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AH4AK4_2177	COG3313	Fe-S protein
AH4AK4_2178	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2178	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AH4AK4_2178	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2179	COG1105	Belongs to the carbohydrate kinase PfkB family
AH4AK4_2180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_2180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_2181	COG1609	Transcriptional regulator
AH4AK4_2182	COG0814	amino acid
AH4AK4_2184	COG5654	RES domain protein
AH4AK4_2189	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AH4AK4_2190	COG0513	Belongs to the DEAD box helicase family
AH4AK4_2192	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AH4AK4_2193	COG2890	protein-(glutamine-N5) methyltransferase activity
AH4AK4_2194	COG2840	Smr protein MutS2
AH4AK4_2201	COG2824	Alkylphosphonate utilization operon protein PhnA
AH4AK4_2203	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_2213	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AH4AK4_2214	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AH4AK4_2216	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AH4AK4_2217	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AH4AK4_2219	COG0205	6-phosphofructokinase activity
AH4AK4_2221	COG1473	amidohydrolase
AH4AK4_2222	COG1011	Hydrolase
AH4AK4_2223	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_2228	COG3593	DNA synthesis involved in DNA repair
AH4AK4_2232	COG0583	DNA-binding transcription factor activity
AH4AK4_2233	COG0730	response to heat
AH4AK4_2236	COG1181	Belongs to the D-alanine--D-alanine ligase family
AH4AK4_2238	COG0386	Belongs to the glutathione peroxidase family
AH4AK4_2239	COG0513	Belongs to the DEAD box helicase family
AH4AK4_2242	COG1742	UPF0060 membrane protein
AH4AK4_2247	COG2329	Antibiotic biosynthesis monooxygenase
AH4AK4_2248	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AH4AK4_2254	COG2501	S4 domain
AH4AK4_2257	COG1132	(ABC) transporter
AH4AK4_2258	COG1132	(ABC) transporter
AH4AK4_2260	COG3118	belongs to the thioredoxin family
AH4AK4_2261	COG0471	metal ion transport
AH4AK4_2263	COG0058	SHG alpha-glucan phosphorylase activity
AH4AK4_2273	COG0814	amino acid
AH4AK4_2274	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AH4AK4_2275	COG0514	ATP-dependent DNA helicase (RecQ)
AH4AK4_2276	COG2766	serine protein kinase
AH4AK4_2277	COG2718	Belongs to the UPF0229 family
AH4AK4_2278	COG2719	SpoVR family
AH4AK4_2280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_2281	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AH4AK4_2282	COG0586	Pfam SNARE associated Golgi protein
AH4AK4_2284	COG0556	nucleotide-excision repair
AH4AK4_2286	COG0569	domain protein
AH4AK4_2286	COG2985	domain, Protein
AH4AK4_2287	COG1196	nuclear chromosome segregation
AH4AK4_2287	COG0741	lytic transglycosylase activity
AH4AK4_2287	COG0739	heme binding
AH4AK4_2291	COG4565	transcriptional regulatory protein
AH4AK4_2292	COG3290	protein histidine kinase activity
AH4AK4_2293	COG1940	carbohydrate kinase activity
AH4AK4_2293	COG1846	Transcriptional regulator
AH4AK4_2295	COG3012	SEC-C Motif Domain Protein
AH4AK4_2296	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AH4AK4_2297	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AH4AK4_2298	COG0247	lactate metabolic process
AH4AK4_2301	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AH4AK4_2302	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_2303	COG3301	Polysulphide reductase, NrfD
AH4AK4_2304	COG1138	Cytochrome C-type biogenesis protein
AH4AK4_2306	COG4235	cytochrome complex assembly
AH4AK4_2306	COG3088	subunit of a heme lyase
AH4AK4_2307	COG1051	belongs to the nudix hydrolase family
AH4AK4_2309	COG3046	protein related to deoxyribodipyrimidine photolyase
AH4AK4_2310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_2313	COG0517	IMP dehydrogenase activity
AH4AK4_2313	COG0516	GMP reductase activity
AH4AK4_2315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AH4AK4_2316	COG0583	DNA-binding transcription factor activity
AH4AK4_2320	COG3706	GGDEF domain
AH4AK4_2321	COG4977	sequence-specific DNA binding
AH4AK4_2321	COG1917	Cupin 2, conserved barrel domain protein
AH4AK4_2324	COG2910	NAD(P)H-binding
AH4AK4_2326	COG0626	cystathionine gamma-synthase activity
AH4AK4_2327	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AH4AK4_2331	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AH4AK4_2335	COG1435	thymidine kinase activity
AH4AK4_2336	COG1757	Na H antiporter
AH4AK4_2337	COG2916	Histone family protein nucleoid-structuring protein H-NS
AH4AK4_2338	COG2096	Adenosyltransferase
AH4AK4_2339	COG3530	Putative quorum-sensing-regulated virulence factor
AH4AK4_2340	COG0602	queuosine metabolic process
AH4AK4_2341	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AH4AK4_2345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AH4AK4_2347	COG0776	regulation of translation
AH4AK4_2348	COG0539	negative regulation of cytoplasmic translation
AH4AK4_2349	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AH4AK4_2350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AH4AK4_2355	COG0778	Nitroreductase
AH4AK4_2356	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AH4AK4_2357	COG5001	Diguanylate cyclase
AH4AK4_2357	COG3300	MHYT domain
AH4AK4_2359	COG0583	DNA-binding transcription factor activity
AH4AK4_2360	COG0745	RESPONSE REGULATOR receiver
AH4AK4_2365	COG4989	oxidoreductase activity
AH4AK4_2366	COG0724	RNA recognition motif
AH4AK4_2371	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AH4AK4_2374	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_2375	COG1360	Flagellar Motor Protein
AH4AK4_2376	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_2377	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_2378	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_2378	COG0649	NAD binding
AH4AK4_2381	COG1034	ATP synthesis coupled electron transport
AH4AK4_2382	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AH4AK4_2383	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_2384	COG0839	Belongs to the complex I subunit 6 family
AH4AK4_2385	COG0713	ATP synthesis coupled electron transport
AH4AK4_2387	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_2388	COG1007	ATP synthesis coupled electron transport
AH4AK4_2390	COG0047	phosphoribosylformylglycinamidine synthase activity
AH4AK4_2390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AH4AK4_2392	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AH4AK4_2394	COG1645	bacterial-type flagellum-dependent swarming motility
AH4AK4_2395	COG1160	GTP binding
AH4AK4_2396	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_2397	COG2976	Protein conserved in bacteria
AH4AK4_2398	COG0124	histidyl-tRNA synthetase
AH4AK4_2399	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AH4AK4_2400	COG1426	Protein conserved in bacteria
AH4AK4_2402	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AH4AK4_2403	COG0105	UTP biosynthetic process
AH4AK4_2404	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_2406	COG0633	Ferredoxin
AH4AK4_2407	COG0443	Heat shock 70 kDa protein
AH4AK4_2408	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AH4AK4_2410	COG0822	iron-sulfur transferase activity
AH4AK4_2411	COG1104	cysteine desulfurase activity
AH4AK4_2420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_2421	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_2422	COG1862	Preprotein translocase
AH4AK4_2423	COG0343	queuine tRNA-ribosyltransferase activity
AH4AK4_2424	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AH4AK4_2425	COG0517	IMP dehydrogenase activity
AH4AK4_2426	COG0450	alkyl hydroperoxide reductase
AH4AK4_2427	COG3634	alkyl hydroperoxide reductase activity
AH4AK4_2428	COG2814	Major facilitator Superfamily
AH4AK4_2433	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_2434	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AH4AK4_2435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AH4AK4_2435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AH4AK4_2437	COG0509	glycine decarboxylation via glycine cleavage system
AH4AK4_2438	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AH4AK4_2439	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_2440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_2441	COG3079	Belongs to the UPF0149 family
AH4AK4_2443	COG1609	Transcriptional regulator
AH4AK4_2444	COG1129	ABC transporter
AH4AK4_2445	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_2446	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_2448	COG0673	inositol 2-dehydrogenase activity
AH4AK4_2449	COG2814	Major facilitator Superfamily
AH4AK4_2450	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_2451	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_2452	COG0601	transmembrane transport
AH4AK4_2454	COG0625	glutathione transferase activity
AH4AK4_2457	COG0483	inositol monophosphate 1-phosphatase activity
AH4AK4_2461	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AH4AK4_2462	COG2056	Na+-H+ antiporter family
AH4AK4_2463	COG2814	Major facilitator Superfamily
AH4AK4_2464	COG0583	DNA-binding transcription factor activity
AH4AK4_2466	COG0513	Belongs to the DEAD box helicase family
AH4AK4_2467	COG2050	protein possibly involved in aromatic compounds catabolism
AH4AK4_2469	COG0277	FAD linked oxidase domain protein
AH4AK4_2469	COG0247	lactate metabolic process
AH4AK4_2472	COG1253	flavin adenine dinucleotide binding
AH4AK4_2473	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_2474	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AH4AK4_2475	COG0647	UMP catabolic process
AH4AK4_2477	COG0367	asparagine synthase
AH4AK4_2479	COG0625	glutathione transferase activity
AH4AK4_2481	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AH4AK4_2484	COG0564	pseudouridine synthase activity
AH4AK4_2485	COG3706	GGDEF domain
AH4AK4_2486	COG0840	transmembrane signaling receptor activity
AH4AK4_2487	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_2489	COG2207	Transcriptional regulator
AH4AK4_2496	COG2855	membrane
AH4AK4_2498	COG2814	Major facilitator Superfamily
AH4AK4_2499	COG3246	L-lysine catabolic process to acetate
AH4AK4_2500	COG2175	clavaminate synthase activity
AH4AK4_2502	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AH4AK4_2507	COG4932	domain protein
AH4AK4_2507	COG5492	domain, Protein
AH4AK4_2510	COG3188	usher protein
AH4AK4_2511	COG3121	Chaperone
AH4AK4_2512	COG3539	Fimbrial protein
AH4AK4_2514	COG0670	Belongs to the BI1 family
AH4AK4_2515	COG1289	transmembrane transporter activity
AH4AK4_2516	COG2920	part of a sulfur-relay system
AH4AK4_2517	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AH4AK4_2518	COG0285	dihydrofolate synthase activity
AH4AK4_2519	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AH4AK4_2520	COG0101	tRNA pseudouridine synthase activity
AH4AK4_2523	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AH4AK4_2524	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH4AK4_2525	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_2526	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_2529	COG1119	ATPase activity
AH4AK4_2533	COG0574	Belongs to the PEP-utilizing enzyme family
AH4AK4_2533	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AH4AK4_2534	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AH4AK4_2536	COG1113	amino acid transport
AH4AK4_2545	COG1242	4 iron, 4 sulfur cluster binding
AH4AK4_2546	COG0070	glutamate synthase
AH4AK4_2546	COG0067	glutamate synthase
AH4AK4_2546	COG0069	glutamate synthase activity
AH4AK4_2547	COG0493	'glutamate synthase
AH4AK4_2548	COG1126	abc transporter atp-binding protein
AH4AK4_2549	COG0765	amino acid transport
AH4AK4_2550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_2551	COG0789	Transcriptional regulator
AH4AK4_2554	COG4104	PAAR repeat-containing protein
AH4AK4_2556	COG0513	Belongs to the DEAD box helicase family
AH4AK4_2561	COG3706	GGDEF domain
AH4AK4_2562	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AH4AK4_2564	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AH4AK4_2565	COG0505	Belongs to the CarA family
AH4AK4_2566	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AH4AK4_2568	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AH4AK4_2569	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AH4AK4_2571	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH4AK4_2572	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AH4AK4_2573	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_2574	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AH4AK4_2575	COG4139	cobalamin transport
AH4AK4_2583	COG0023	Translation Initiation Factor
AH4AK4_2584	COG2119	membrane
AH4AK4_2591	COG2203	Gaf domain
AH4AK4_2591	COG2199	diguanylate cyclase activity
AH4AK4_2596	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH4AK4_2598	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_2599	COG2261	transglycosylase associated protein
AH4AK4_2600	COG0625	glutathione transferase activity
AH4AK4_2605	COG4974	Belongs to the 'phage' integrase family
AH4AK4_2624	COG4695	Portal protein
AH4AK4_2639	COG3646	Phage regulatory protein
AH4AK4_2646	COG5301	cellulose 1,4-beta-cellobiosidase activity
AH4AK4_2661	COG0322	excinuclease ABC activity
AH4AK4_2663	COG2197	response regulator
AH4AK4_2664	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AH4AK4_2665	COG2835	tetraacyldisaccharide 4'-kinase activity
AH4AK4_2666	COG1663	tetraacyldisaccharide 4'-kinase activity
AH4AK4_2667	COG1132	(ABC) transporter
AH4AK4_2668	COG0658	competence protein
AH4AK4_2668	COG2333	competence protein COMEC
AH4AK4_2671	COG0433	COG0433 Predicted ATPase
AH4AK4_2672	COG1448	Aminotransferase
AH4AK4_2674	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AH4AK4_2675	COG1199	ATP-dependent helicase activity
AH4AK4_2677	COG0123	including yeast histone deacetylase and acetoin utilization protein
AH4AK4_2678	COG0477	Major facilitator Superfamily
AH4AK4_2679	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AH4AK4_2680	COG1785	Belongs to the alkaline phosphatase family
AH4AK4_2684	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH4AK4_2685	COG2197	response regulator
AH4AK4_2689	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_2690	COG0765	amino acid transport
AH4AK4_2693	COG1126	abc transporter atp-binding protein
AH4AK4_2696	COG0531	amino acid
AH4AK4_2699	COG1253	flavin adenine dinucleotide binding
AH4AK4_2702	COG0581	inorganic phosphate transmembrane transporter activity
AH4AK4_2703	COG0573	inorganic phosphate transmembrane transporter activity
AH4AK4_2704	COG0590	tRNA wobble adenosine to inosine editing
AH4AK4_2707	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AH4AK4_2711	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AH4AK4_2712	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AH4AK4_2713	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AH4AK4_2714	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AH4AK4_2716	COG2204	response regulator
AH4AK4_2717	COG3852	Histidine kinase
AH4AK4_2718	COG2204	response regulator
AH4AK4_2721	COG2716	regulation of RNA biosynthetic process
AH4AK4_2722	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AH4AK4_2723	COG0248	Ppx GppA phosphatase
AH4AK4_2724	COG2239	Acts as a magnesium transporter
AH4AK4_2727	COG3951	Flagellar rod assembly protein muramidase FlgJ
AH4AK4_2727	COG1705	Flagellar rod assembly protein muramidase FlgJ
AH4AK4_2728	COG1706	bacterial-type flagellum-dependent cell motility
AH4AK4_2729	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AH4AK4_2730	COG4786	Flagellar basal body rod
AH4AK4_2732	COG1749	Flagellar hook protein flgE
AH4AK4_2734	COG1558	bacterial-type flagellum-dependent cell motility
AH4AK4_2735	COG1815	bacterial-type flagellum-dependent cell motility
AH4AK4_2736	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AH4AK4_2737	COG0835	chemotaxis
AH4AK4_2737	COG0784	Response regulator, receiver
AH4AK4_2738	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AH4AK4_2741	COG0622	Phosphoesterase
AH4AK4_2742	COG4166	transmembrane transport
AH4AK4_2744	COG1187	pseudouridine synthase activity
AH4AK4_2747	COG0697	spore germination
AH4AK4_2753	COG1278	Cold shock
AH4AK4_2762	COG3132	Protein of unknown function, DUF480
AH4AK4_2768	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AH4AK4_2770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AH4AK4_2772	COG0438	transferase activity, transferring glycosyl groups
AH4AK4_2776	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AH4AK4_2778	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AH4AK4_2779	COG1088	dTDP-glucose 4,6-dehydratase activity
AH4AK4_2781	COG2205	protein histidine kinase activity
AH4AK4_2783	COG0837	glucose binding
AH4AK4_2784	COG1737	Transcriptional regulator
AH4AK4_2785	COG0469	pyruvate kinase activity
AH4AK4_2787	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_2788	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_2790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AH4AK4_2801	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH4AK4_2805	COG1061	Type III restriction enzyme res subunit
AH4AK4_2814	COG2003	Belongs to the UPF0758 family
AH4AK4_2817	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AH4AK4_2818	COG1538	Outer membrane efflux protein
AH4AK4_2819	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_2820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_2821	COG1309	transcriptional regulator
AH4AK4_2824	COG1946	Acyl-CoA thioesterase
AH4AK4_2826	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AH4AK4_2828	COG0009	L-threonylcarbamoyladenylate synthase
AH4AK4_2829	COG0613	PHP domain protein
AH4AK4_2831	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AH4AK4_2832	COG0512	Glutamine amidotransferase of anthranilate synthase
AH4AK4_2832	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH4AK4_2833	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH4AK4_2834	COG0134	indole-3-glycerol-phosphate synthase activity
AH4AK4_2834	COG0135	phosphoribosylanthranilate isomerase activity
AH4AK4_2835	COG0133	tryptophan synthase activity
AH4AK4_2836	COG0159	tryptophan synthase activity
AH4AK4_2839	COG1988	membrane-bound metal-dependent
AH4AK4_2843	COG0583	DNA-binding transcription factor activity
AH4AK4_2845	COG4521	taurine ABC transporter
AH4AK4_2846	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AH4AK4_2847	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_2848	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_2849	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_2850	COG2175	clavaminate synthase activity
AH4AK4_2851	COG5507	3-demethylubiquinone-9 3-methyltransferase
AH4AK4_2852	COG2814	Major facilitator Superfamily
AH4AK4_2853	COG0109	protoheme IX farnesyltransferase activity
AH4AK4_2854	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AH4AK4_2855	COG1845	cytochrome c oxidase, subunit III
AH4AK4_2856	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AH4AK4_2857	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AH4AK4_2858	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AH4AK4_2859	COG0583	DNA-binding transcription factor activity
AH4AK4_2869	COG0708	Exodeoxyribonuclease III
AH4AK4_2871	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_2872	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_2875	COG0095	Lipoate-protein ligase
AH4AK4_2877	COG0577	efflux transmembrane transporter activity
AH4AK4_2877	COG1136	(ABC) transporter
AH4AK4_2878	COG0577	efflux transmembrane transporter activity
AH4AK4_2878	COG1136	(ABC) transporter
AH4AK4_2879	COG0577	efflux transmembrane transporter activity
AH4AK4_2879	COG1136	(ABC) transporter
AH4AK4_2883	COG0640	Transcriptional regulator
AH4AK4_2885	COG1285	pathogenesis
AH4AK4_2891	COG0484	heat shock protein binding
AH4AK4_2892	COG0443	Heat shock 70 kDa protein
AH4AK4_2893	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AH4AK4_2894	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AH4AK4_2895	COG3706	GGDEF domain
AH4AK4_2896	COG0497	DNA recombination
AH4AK4_2897	COG1227	inorganic diphosphatase activity
AH4AK4_2899	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_2900	COG0577	efflux transmembrane transporter activity
AH4AK4_2900	COG1136	(ABC) transporter
AH4AK4_2901	COG1538	Outer membrane efflux protein
AH4AK4_2902	COG2375	cellular response to nickel ion
AH4AK4_2904	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_2905	COG2916	Histone family protein nucleoid-structuring protein H-NS
AH4AK4_2906	COG0583	DNA-binding transcription factor activity
AH4AK4_2907	COG2610	gluconate transmembrane transporter activity
AH4AK4_2908	COG3048	D-serine ammonia-lyase activity
AH4AK4_2911	COG0538	isocitrate dehydrogenase activity
AH4AK4_2912	COG2207	Transcriptional regulator
AH4AK4_2913	COG1482	cell wall glycoprotein biosynthetic process
AH4AK4_2916	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2919	COG4932	domain protein
AH4AK4_2919	COG5492	domain, Protein
AH4AK4_2921	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2921	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2921	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_2924	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_2925	COG3711	transcriptional antiterminator
AH4AK4_2925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_2926	COG1187	pseudouridine synthase activity
AH4AK4_2928	COG0482	sulfurtransferase activity
AH4AK4_2929	COG2915	High frequency lysogenization protein hflD homolog
AH4AK4_2930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AH4AK4_2931	COG2850	peptidyl-arginine hydroxylation
AH4AK4_2932	COG0469	pyruvate kinase activity
AH4AK4_2933	COG1196	nuclear chromosome segregation
AH4AK4_2933	COG3264	Mechanosensitive ion channel
AH4AK4_2935	COG2706	6-phosphogluconolactonase activity
AH4AK4_2940	COG0281	malic enzyme
AH4AK4_2941	COG0746	molybdenum cofactor guanylyltransferase activity
AH4AK4_2942	COG1763	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_2943	COG1289	transmembrane transporter activity
AH4AK4_2944	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AH4AK4_2952	COG3220	belongs to the UPF0276 family
AH4AK4_2957	COG0454	-acetyltransferase
AH4AK4_2958	COG1396	sequence-specific DNA binding
AH4AK4_2960	COG4319	ketosteroid isomerase
AH4AK4_2961	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AH4AK4_2962	COG0083	homoserine kinase activity
AH4AK4_2964	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AH4AK4_2965	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AH4AK4_2968	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AH4AK4_2970	COG0745	RESPONSE REGULATOR receiver
AH4AK4_2973	COG4988	ABC transporter
AH4AK4_2974	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AH4AK4_2978	COG1720	tRNA m6t6A37 methyltransferase activity
AH4AK4_2981	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AH4AK4_2982	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AH4AK4_2983	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_2985	COG2190	(PTS) system
AH4AK4_2986	COG3038	cytochrome b561
AH4AK4_2987	COG0419	ATPase involved in DNA repair
AH4AK4_2988	COG0420	3'-5' exonuclease activity
AH4AK4_2989	COG0456	acetyltransferase
AH4AK4_2990	COG2974	May be involved in recombination
AH4AK4_2992	COG0405	Gamma-glutamyltransferase
AH4AK4_2993	COG4651	solute:proton antiporter activity
AH4AK4_2993	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AH4AK4_3000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_3001	COG1917	Cupin 2, conserved barrel domain protein
AH4AK4_3001	COG1396	sequence-specific DNA binding
AH4AK4_3004	COG0531	amino acid
AH4AK4_3005	COG0531	amino acid
AH4AK4_3007	COG1283	sodium-dependent phosphate transmembrane transporter activity
AH4AK4_3009	COG3384	dioxygenase
AH4AK4_3010	COG2205	protein histidine kinase activity
AH4AK4_3010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_3016	COG0784	Response regulator, receiver
AH4AK4_3016	COG2205	protein histidine kinase activity
AH4AK4_3022	COG3158	transport of potassium into the cell
AH4AK4_3025	COG1388	LysM domain
AH4AK4_3025	COG1376	ErfK ybiS ycfS ynhG family protein
AH4AK4_3028	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AH4AK4_3029	COG0791	NLP P60 protein
AH4AK4_3031	COG3118	belongs to the thioredoxin family
AH4AK4_3033	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AH4AK4_3035	COG0788	formyltetrahydrofolate deformylase activity
AH4AK4_3040	COG0739	heme binding
AH4AK4_3040	COG0741	lytic transglycosylase activity
AH4AK4_3040	COG1196	nuclear chromosome segregation
AH4AK4_3042	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH4AK4_3043	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AH4AK4_3044	COG0673	inositol 2-dehydrogenase activity
AH4AK4_3049	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AH4AK4_3050	COG1032	radical SAM domain protein
AH4AK4_3052	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_3054	COG3706	GGDEF domain
AH4AK4_3055	COG1752	Esterase of the alpha-beta hydrolase superfamily
AH4AK4_3056	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_3063	COG0281	malic enzyme
AH4AK4_3064	COG2207	Transcriptional regulator
AH4AK4_3065	COG0534	Mate efflux family protein
AH4AK4_3068	COG0745	RESPONSE REGULATOR receiver
AH4AK4_3068	COG3706	GGDEF domain
AH4AK4_3070	COG2233	PERMEase
AH4AK4_3071	COG0095	Lipoate-protein ligase
AH4AK4_3072	COG1115	amino acid carrier protein
AH4AK4_3073	COG0019	diaminopimelate decarboxylase activity
AH4AK4_3075	COG0678	peroxiredoxin activity
AH4AK4_3076	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AH4AK4_3078	COG1126	abc transporter atp-binding protein
AH4AK4_3079	COG0765	amino acid transport
AH4AK4_3080	COG4597	amino acid ABC transporter
AH4AK4_3081	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_3085	COG1131	(ABC) transporter
AH4AK4_3086	COG0545	Peptidyl-prolyl cis-trans isomerase
AH4AK4_3088	COG1940	carbohydrate kinase activity
AH4AK4_3090	COG4783	chaperone-mediated protein folding
AH4AK4_3092	COG5002	protein histidine kinase activity
AH4AK4_3093	COG0745	RESPONSE REGULATOR receiver
AH4AK4_3094	COG0346	lactoylglutathione lyase activity
AH4AK4_3095	COG3706	GGDEF domain
AH4AK4_3096	COG3284	Transcriptional regulator
AH4AK4_3098	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_3100	COG0697	spore germination
AH4AK4_3102	COG3290	protein histidine kinase activity
AH4AK4_3103	COG0281	malic enzyme
AH4AK4_3106	COG1846	Transcriptional regulator
AH4AK4_3107	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_3112	COG0602	queuosine metabolic process
AH4AK4_3115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AH4AK4_3117	COG1196	nuclear chromosome segregation
AH4AK4_3119	COG2860	membrane
AH4AK4_3121	COG3108	Peptidase M15
AH4AK4_3122	COG2989	Protein conserved in bacteria
AH4AK4_3125	COG0463	Glycosyl transferase, family 2
AH4AK4_3128	COG0366	Alpha amylase catalytic
AH4AK4_3135	COG3706	GGDEF domain
AH4AK4_3136	COG0037	tRNA processing
AH4AK4_3137	COG3590	peptidase
AH4AK4_3141	COG0531	amino acid
AH4AK4_3142	COG0814	amino acid
AH4AK4_3143	COG0583	DNA-binding transcription factor activity
AH4AK4_3145	COG3459	Glycosyltransferase 36 associated
AH4AK4_3148	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_3149	COG0825	malonyl-CoA metabolic process
AH4AK4_3151	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AH4AK4_3152	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_3153	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_3154	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AH4AK4_3155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_3158	COG0750	zinc metalloprotease
AH4AK4_3159	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AH4AK4_3160	COG0575	Belongs to the CDS family
AH4AK4_3162	COG0233	cytoplasmic translational termination
AH4AK4_3163	COG0528	UMP kinase activity
AH4AK4_3165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AH4AK4_3166	COG0052	Belongs to the universal ribosomal protein uS2 family
AH4AK4_3167	COG0024	Methionine aminopeptidase
AH4AK4_3168	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AH4AK4_3169	COG2171	N-acyltransferase activity
AH4AK4_3171	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_3171	COG1263	PTS System
AH4AK4_3173	COG4580	involved in the transport of maltose and maltodextrins
AH4AK4_3175	COG0564	pseudouridine synthase activity
AH4AK4_3176	COG3098	single-species biofilm formation
AH4AK4_3182	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AH4AK4_3184	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AH4AK4_3184	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AH4AK4_3186	COG3706	GGDEF domain
AH4AK4_3188	COG1611	Belongs to the LOG family
AH4AK4_3189	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_3190	COG0473	3-isopropylmalate dehydrogenase activity
AH4AK4_3192	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AH4AK4_3193	COG2363	Small membrane protein
AH4AK4_3195	COG0583	DNA-binding transcription factor activity
AH4AK4_3196	COG0840	transmembrane signaling receptor activity
AH4AK4_3197	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH4AK4_3200	COG1477	protein flavinylation
AH4AK4_3201	COG2871	sodium ion transport
AH4AK4_3202	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_3203	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_3204	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_3205	COG1805	sodium ion transport
AH4AK4_3206	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_3207	COG0271	Belongs to the BolA IbaG family
AH4AK4_3208	COG2813	Specifically methylates the guanine in position
AH4AK4_3210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH4AK4_3212	COG2211	Major facilitator Superfamily
AH4AK4_3213	COG3248	Nucleoside-binding outer membrane protein
AH4AK4_3214	COG1666	GTP binding
AH4AK4_3215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AH4AK4_3223	COG3501	Rhs element vgr protein
AH4AK4_3225	COG2771	luxR family
AH4AK4_3227	COG2072	flavoprotein involved in K transport
AH4AK4_3228	COG1393	Belongs to the ArsC family
AH4AK4_3229	COG0798	PFAM Bile acid sodium symporter
AH4AK4_3231	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_3238	COG5002	protein histidine kinase activity
AH4AK4_3238	COG5000	phosphorelay sensor kinase activity
AH4AK4_3239	COG0745	RESPONSE REGULATOR receiver
AH4AK4_3240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_3241	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_3244	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_3244	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AH4AK4_3245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH4AK4_3246	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_3247	COG1151	hydroxylamine reductase activity
AH4AK4_3248	COG0783	Belongs to the Dps family
AH4AK4_3253	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AH4AK4_3256	COG0300	oxidoreductase activity
AH4AK4_3259	COG0789	Transcriptional regulator
AH4AK4_3260	COG3272	Protein of unknown function (DUF1722)
AH4AK4_3266	COG0077	Prephenate dehydratase
AH4AK4_3266	COG1605	Chorismate mutase
AH4AK4_3271	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_3274	COG0457	Tetratricopeptide repeat
AH4AK4_3278	COG2133	pyrroloquinoline quinone binding
AH4AK4_3280	COG1349	DNA-binding transcription factor activity
AH4AK4_3281	COG2084	Dehydrogenase
AH4AK4_3283	COG0235	Class ii aldolase
AH4AK4_3284	COG3622	Belongs to the hyi family
AH4AK4_3285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AH4AK4_3286	COG2610	gluconate transmembrane transporter activity
AH4AK4_3288	COG0840	transmembrane signaling receptor activity
AH4AK4_3291	COG0300	oxidoreductase activity
AH4AK4_3296	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AH4AK4_3300	COG3813	Protein conserved in bacteria
AH4AK4_3302	COG0826	peptidase U32
AH4AK4_3304	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_3306	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AH4AK4_3311	COG2205	protein histidine kinase activity
AH4AK4_3311	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_3312	COG2197	response regulator
AH4AK4_3314	COG3188	usher protein
AH4AK4_3317	COG2200	EAL domain
AH4AK4_3317	COG2199	diguanylate cyclase activity
AH4AK4_3317	COG2203	Gaf domain
AH4AK4_3325	COG0114	fumarate hydratase activity
AH4AK4_3327	COG0506	proline dehydrogenase activity
AH4AK4_3327	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AH4AK4_3327	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AH4AK4_3328	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH4AK4_3329	COG0305	Participates in initiation and elongation during chromosome replication
AH4AK4_3332	COG0737	Belongs to the 5'-nucleotidase family
AH4AK4_3336	COG2204	response regulator
AH4AK4_3337	COG0545	Peptidyl-prolyl cis-trans isomerase
AH4AK4_3339	COG2900	Belongs to the SlyX family
AH4AK4_3340	COG1047	Peptidyl-prolyl cis-trans
AH4AK4_3341	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AH4AK4_3343	COG0784	Response regulator, receiver
AH4AK4_3343	COG0835	chemotaxis
AH4AK4_3344	COG0429	hydrolase of the alpha beta-hydrolase fold
AH4AK4_3345	COG3706	GGDEF domain
AH4AK4_3345	COG4251	negative regulation of phosphorylation
AH4AK4_3345	COG5001	Diguanylate cyclase
AH4AK4_3345	COG2203	Gaf domain
AH4AK4_3346	COG3089	Belongs to the UPF0270 family
AH4AK4_3347	COG3954	Phosphoribulokinase
AH4AK4_3350	COG1765	OsmC-like protein
AH4AK4_3351	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH4AK4_3356	COG2205	protein histidine kinase activity
AH4AK4_3357	COG2814	Major facilitator Superfamily
AH4AK4_3362	COG0748	coenzyme F420 binding
AH4AK4_3363	COG3721	Heme iron utilization protein
AH4AK4_3365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_3371	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AH4AK4_3373	COG0463	Glycosyl transferase, family 2
AH4AK4_3375	COG0741	lytic transglycosylase activity
AH4AK4_3376	COG0488	(ABC) transporter
AH4AK4_3378	COG2252	PERMEase
AH4AK4_3379	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AH4AK4_3380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AH4AK4_3381	COG3178	'Phosphotransferase
AH4AK4_3382	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AH4AK4_3384	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AH4AK4_3385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AH4AK4_3387	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AH4AK4_3390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AH4AK4_3391	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AH4AK4_3393	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AH4AK4_3394	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AH4AK4_3395	COG0142	geranyltranstransferase activity
AH4AK4_3396	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AH4AK4_3397	COG0330	HflC and HflK could
AH4AK4_3398	COG0330	HflC and HflK could
AH4AK4_3399	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AH4AK4_3400	COG1923	regulation of RNA biosynthetic process
AH4AK4_3401	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AH4AK4_3402	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AH4AK4_3404	COG0802	atpase or kinase
AH4AK4_3405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AH4AK4_3405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AH4AK4_3410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH4AK4_3411	COG2011	ABC-type metal ion transport system permease component
AH4AK4_3412	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_3414	COG0840	transmembrane signaling receptor activity
AH4AK4_3416	COG0784	Response regulator, receiver
AH4AK4_3416	COG2205	protein histidine kinase activity
AH4AK4_3418	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AH4AK4_3419	COG2198	Histidine kinase
AH4AK4_3419	COG0784	Response regulator, receiver
AH4AK4_3419	COG5002	protein histidine kinase activity
AH4AK4_3426	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AH4AK4_3427	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AH4AK4_3429	COG2716	regulation of RNA biosynthetic process
AH4AK4_3430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AH4AK4_3431	COG3013	Belongs to the UPF0304 family
AH4AK4_3432	COG3092	negative regulation of chromosome organization
AH4AK4_3433	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AH4AK4_3434	COG0280	phosphate acetyltransferase
AH4AK4_3434	COG0857	belongs to the CobB CobQ family
AH4AK4_3435	COG0440	acetolactate synthase activity
AH4AK4_3436	COG0028	Belongs to the TPP enzyme family
AH4AK4_3438	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AH4AK4_3439	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_3441	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AH4AK4_3442	COG0473	3-isopropylmalate dehydrogenase activity
AH4AK4_3443	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AH4AK4_3444	COG0066	3-isopropylmalate dehydratase activity
AH4AK4_3447	COG4143	(ABC) transporter
AH4AK4_3448	COG1178	ABC-type Fe3 transport system permease component
AH4AK4_3450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AH4AK4_3458	COG0316	Belongs to the HesB IscA family
AH4AK4_3460	COG0038	chloride channel
AH4AK4_3462	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AH4AK4_3466	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_3468	COG0583	DNA-binding transcription factor activity
AH4AK4_3469	COG2076	Multidrug Resistance protein
AH4AK4_3471	COG0346	lactoylglutathione lyase activity
AH4AK4_3472	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH4AK4_3473	COG1643	Atp-dependent helicase
AH4AK4_3475	COG1489	DNA binding
AH4AK4_3476	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AH4AK4_3477	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_3479	COG0617	tRNA 3'-terminal CCA addition
AH4AK4_3481	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AH4AK4_3482	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AH4AK4_3484	COG0842	Transport permease protein
AH4AK4_3485	COG1131	(ABC) transporter
AH4AK4_3488	COG0163	prenyltransferase activity
AH4AK4_3489	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AH4AK4_3490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AH4AK4_3493	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AH4AK4_3496	COG1136	(ABC) transporter
AH4AK4_3503	COG0529	Catalyzes the synthesis of activated sulfate
AH4AK4_3504	COG3273	potassium ion transport
AH4AK4_3504	COG0471	metal ion transport
AH4AK4_3505	COG2895	sulfate adenylyltransferase (ATP) activity
AH4AK4_3506	COG0175	sulfate reduction
AH4AK4_3507	COG1648	precorrin-2 dehydrogenase activity
AH4AK4_3507	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AH4AK4_3508	COG0330	HflC and HflK could
AH4AK4_3509	COG1585	Membrane protein implicated in regulation of membrane protease activity
AH4AK4_3511	COG0673	inositol 2-dehydrogenase activity
AH4AK4_3512	COG2814	Major facilitator Superfamily
AH4AK4_3513	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AH4AK4_3514	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AH4AK4_3515	COG3036	rescue of stalled ribosome
AH4AK4_3519	COG0138	bifunctional purine biosynthesis protein purh
AH4AK4_3520	COG0151	Belongs to the GarS family
AH4AK4_3526	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AH4AK4_3528	COG1610	YqeY-like protein
AH4AK4_3529	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AH4AK4_3530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AH4AK4_3532	COG1388	LysM domain
AH4AK4_3532	COG4942	peptidase
AH4AK4_3533	COG1238	metal cluster binding
AH4AK4_3534	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AH4AK4_3535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AH4AK4_3536	COG0585	pseudouridine synthase activity
AH4AK4_3538	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AH4AK4_3539	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AH4AK4_3540	COG0148	phosphopyruvate hydratase activity
AH4AK4_3541	COG0504	CTP synthase activity
AH4AK4_3542	COG3956	TIGRFAM MazG family protein
AH4AK4_3543	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH4AK4_3544	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_3546	COG4807	Protein conserved in bacteria
AH4AK4_3547	COG3023	N-Acetylmuramoyl-L-alanine amidase
AH4AK4_3548	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AH4AK4_3549	COG1381	Involved in DNA repair and RecF pathway recombination
AH4AK4_3551	COG0571	ribonuclease III activity
AH4AK4_3552	COG0681	Belongs to the peptidase S26 family
AH4AK4_3553	COG0481	GTPase activity
AH4AK4_3557	COG1595	DNA-templated transcription, initiation
AH4AK4_3558	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AH4AK4_3560	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AH4AK4_3568	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_3569	COG0191	fructose-bisphosphate aldolase activity
AH4AK4_3570	COG0126	phosphoglycerate kinase activity
AH4AK4_3571	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_3572	COG1940	carbohydrate kinase activity
AH4AK4_3573	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AH4AK4_3574	COG2816	NAD+ diphosphatase activity
AH4AK4_3575	COG4991	sh3 domain protein
AH4AK4_3576	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH4AK4_3579	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AH4AK4_3580	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_3582	COG1505	serine-type exopeptidase activity
AH4AK4_3583	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AH4AK4_3584	COG0765	amino acid transport
AH4AK4_3585	COG0765	amino acid transport
AH4AK4_3586	COG1126	abc transporter atp-binding protein
AH4AK4_3587	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_3588	COG3174	membrane
AH4AK4_3589	COG0110	maltose O-acetyltransferase activity
AH4AK4_3593	COG5492	domain, Protein
AH4AK4_3593	COG4932	domain protein
AH4AK4_3599	COG1942	4-Oxalocrotonate Tautomerase
AH4AK4_3601	COG0583	DNA-binding transcription factor activity
AH4AK4_3602	COG0165	Argininosuccinate lyase
AH4AK4_3603	COG0137	argininosuccinate synthase activity
AH4AK4_3605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AH4AK4_3606	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AH4AK4_3608	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AH4AK4_3610	COG3447	MASE1 domain protein
AH4AK4_3610	COG5001	Diguanylate cyclase
AH4AK4_3610	COG5002	protein histidine kinase activity
AH4AK4_3617	COG0583	DNA-binding transcription factor activity
AH4AK4_3618	COG1380	Effector of murein hydrolase LrgA
AH4AK4_3619	COG1346	cytolysis
AH4AK4_3620	COG0527	aspartate kinase activity
AH4AK4_3620	COG0460	homoserine dehydrogenase
AH4AK4_3621	COG0626	cystathionine gamma-synthase activity
AH4AK4_3624	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_3625	COG0814	amino acid
AH4AK4_3626	COG1218	3'(2'),5'-bisphosphate nucleotidase
AH4AK4_3627	COG0494	nUDIX hydrolase
AH4AK4_3628	COG1011	Hydrolase
AH4AK4_3631	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AH4AK4_3634	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AH4AK4_3636	COG3156	type II secretion system protein K
AH4AK4_3637	COG4795	General secretion pathway protein
AH4AK4_3638	COG2165	general secretion pathway protein
AH4AK4_3640	COG2165	general secretion pathway protein
AH4AK4_3641	COG1459	type II secretion system
AH4AK4_3642	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AH4AK4_3644	COG3031	protein transport across the cell outer membrane
AH4AK4_3646	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AH4AK4_3647	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AH4AK4_3651	COG3133	Outer membrane lipoprotein
AH4AK4_3652	COG3025	triphosphatase activity
AH4AK4_3653	COG1392	Phosphate transport regulator
AH4AK4_3654	COG0306	phosphate transporter
AH4AK4_3655	COG0617	tRNA 3'-terminal CCA addition
AH4AK4_3656	COG3267	Type II secretory pathway component ExeA
AH4AK4_3656	COG3409	Peptidoglycan-binding domain 1 protein
AH4AK4_3658	COG1194	a g-specific adenine glycosylase
AH4AK4_3659	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AH4AK4_3663	COG3240	lipase activity
AH4AK4_3665	COG3009	Protein conserved in bacteria
AH4AK4_3666	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AH4AK4_3666	COG3008	intermembrane lipid transfer
AH4AK4_3667	COG2995	paraquat-inducible protein a
AH4AK4_3670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_3671	COG5001	Diguanylate cyclase
AH4AK4_3671	COG4251	negative regulation of phosphorylation
AH4AK4_3671	COG3706	GGDEF domain
AH4AK4_3671	COG2203	Gaf domain
AH4AK4_3672	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AH4AK4_3673	COG2813	Specifically methylates the guanine in position
AH4AK4_3674	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AH4AK4_3675	COG0297	glycogen (starch) synthase activity
AH4AK4_3682	COG1757	Na H antiporter
AH4AK4_3683	COG0583	DNA-binding transcription factor activity
AH4AK4_3684	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AH4AK4_3685	COG3842	ATPase activity
AH4AK4_3686	COG1176	ABC-type spermidine putrescine transport system, permease component I
AH4AK4_3687	COG1177	transmembrane transport
AH4AK4_3688	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_3689	COG0109	protoheme IX farnesyltransferase activity
AH4AK4_3696	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AH4AK4_3698	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AH4AK4_3699	COG1444	tRNA N-acetyltransferase activity
AH4AK4_3703	COG1803	Methylglyoxal synthase
AH4AK4_3706	COG0252	asparaginase activity
AH4AK4_3708	COG1609	Transcriptional regulator
AH4AK4_3711	COG1940	carbohydrate kinase activity
AH4AK4_3712	COG1447	Phosphotransferase system cellobiose-specific component IIA
AH4AK4_3713	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_3714	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_3714	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_3716	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_3718	COG1609	Transcriptional regulator
AH4AK4_3719	COG1263	PTS System
AH4AK4_3719	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_3720	COG0366	Alpha amylase catalytic
AH4AK4_3721	COG0110	maltose O-acetyltransferase activity
AH4AK4_3722	COG1522	sequence-specific DNA binding
AH4AK4_3733	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AH4AK4_3734	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AH4AK4_3737	COG0477	Major facilitator Superfamily
AH4AK4_3738	COG0523	cobalamin synthesis protein
AH4AK4_3740	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_3743	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_3744	COG2200	EAL domain
AH4AK4_3745	COG2200	EAL domain
AH4AK4_3746	COG1049	propionate catabolic process, 2-methylcitrate cycle
AH4AK4_3747	COG1752	Esterase of the alpha-beta hydrolase superfamily
AH4AK4_3748	COG0840	transmembrane signaling receptor activity
AH4AK4_3749	COG0840	transmembrane signaling receptor activity
AH4AK4_3751	COG5002	protein histidine kinase activity
AH4AK4_3751	COG5001	Diguanylate cyclase
AH4AK4_3751	COG3447	MASE1 domain protein
AH4AK4_3752	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH4AK4_3753	COG0508	dehydrogenase complex catalyzes the overall conversion of
AH4AK4_3754	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AH4AK4_3755	COG2186	Transcriptional regulator
AH4AK4_3759	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AH4AK4_3760	COG1459	type II secretion system
AH4AK4_3763	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AH4AK4_3764	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AH4AK4_3765	COG0494	nUDIX hydrolase
AH4AK4_3766	COG0653	protein targeting
AH4AK4_3768	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AH4AK4_3769	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AH4AK4_3770	COG0849	cell division
AH4AK4_3771	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AH4AK4_3772	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AH4AK4_3773	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AH4AK4_3774	COG0772	Belongs to the SEDS family
AH4AK4_3775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AH4AK4_3776	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AH4AK4_3777	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH4AK4_3778	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AH4AK4_3779	COG0768	penicillin binding
AH4AK4_3780	COG3116	cell division
AH4AK4_3781	COG0275	rRNA processing
AH4AK4_3782	COG2001	Belongs to the MraZ family
AH4AK4_3784	COG1388	LysM domain
AH4AK4_3784	COG0741	lytic transglycosylase activity
AH4AK4_3785	COG1360	Flagellar Motor Protein
AH4AK4_3786	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_3787	COG1191	sigma factor activity
AH4AK4_3792	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AH4AK4_3793	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_3794	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_3797	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_3798	COG1256	bacterial-type flagellum assembly
AH4AK4_3798	COG4786	Flagellar basal body rod
AH4AK4_3800	COG1706	bacterial-type flagellum-dependent cell motility
AH4AK4_3801	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AH4AK4_3802	COG4786	Flagellar basal body rod
AH4AK4_3804	COG1749	Flagellar hook protein flgE
AH4AK4_3805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AH4AK4_3806	COG1558	bacterial-type flagellum-dependent cell motility
AH4AK4_3807	COG1815	bacterial-type flagellum-dependent cell motility
AH4AK4_3814	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AH4AK4_3816	COG1677	Flagellar hook-basal body complex protein FliE
AH4AK4_3817	COG2204	response regulator
AH4AK4_3821	COG1987	bacterial-type flagellum assembly
AH4AK4_3825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AH4AK4_3826	COG3107	peptidoglycan biosynthetic process
AH4AK4_3827	COG0792	nuclease activity
AH4AK4_3828	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AH4AK4_3829	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_3830	COG2969	positive regulation of protein catabolic process
AH4AK4_3831	COG0625	glutathione transferase activity
AH4AK4_3832	COG2857	Cytochrome c1
AH4AK4_3833	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AH4AK4_3834	COG0723	plastoquinol--plastocyanin reductase activity
AH4AK4_3835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AH4AK4_3836	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AH4AK4_3837	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AH4AK4_3839	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AH4AK4_3840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AH4AK4_3846	COG3964	amidohydrolase
AH4AK4_3849	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_3849	COG3711	transcriptional antiterminator
AH4AK4_3850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_3851	COG1660	Displays ATPase and GTPase activities
AH4AK4_3852	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_3855	COG1137	ATPase activity
AH4AK4_3856	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AH4AK4_3857	COG3117	lipopolysaccharide transmembrane transporter activity
AH4AK4_3858	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AH4AK4_3859	COG0517	IMP dehydrogenase activity
AH4AK4_3859	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AH4AK4_3860	COG1127	ABC transporter
AH4AK4_3861	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AH4AK4_3862	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AH4AK4_3863	COG2854	intermembrane phospholipid transfer
AH4AK4_3865	COG5007	Belongs to the BolA IbaG family
AH4AK4_3866	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AH4AK4_3867	COG0312	modulator of DNA gyrase
AH4AK4_3868	COG3028	Belongs to the UPF0307 family
AH4AK4_3870	COG2926	Belongs to the UPF0265 family
AH4AK4_3877	COG1396	sequence-specific DNA binding
AH4AK4_3878	COG3135	benzoate transporter
AH4AK4_3884	COG3047	cAMP biosynthetic process
AH4AK4_3886	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AH4AK4_3887	COG2197	response regulator
AH4AK4_3888	COG0629	single-stranded DNA binding
AH4AK4_3892	COG1278	Cold shock
AH4AK4_3893	COG4771	TonB-dependent receptor
AH4AK4_3894	COG4771	TonB-dependent receptor
AH4AK4_3895	COG2205	protein histidine kinase activity
AH4AK4_3896	COG0745	RESPONSE REGULATOR receiver
AH4AK4_3901	COG3706	GGDEF domain
AH4AK4_3902	COG0347	Belongs to the P(II) protein family
AH4AK4_3903	COG0004	ammonium transporteR
AH4AK4_3906	COG1309	transcriptional regulator
AH4AK4_3908	COG0346	lactoylglutathione lyase activity
AH4AK4_3911	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AH4AK4_3912	COG1074	ATP-dependent DNA helicase activity
AH4AK4_3913	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AH4AK4_3914	COG2259	Doxx family
AH4AK4_3915	COG1741	Belongs to the pirin family
AH4AK4_3917	COG0583	DNA-binding transcription factor activity
AH4AK4_3922	COG1175	transmembrane transport
AH4AK4_3924	COG3842	ATPase activity
AH4AK4_3926	COG2199	diguanylate cyclase activity
AH4AK4_3929	COG2207	Transcriptional regulator
AH4AK4_3930	COG1247	-acetyltransferase
AH4AK4_3931	COG0753	catalase activity
AH4AK4_3935	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_3936	COG0628	permease
AH4AK4_3939	COG3284	Transcriptional regulator
AH4AK4_3941	COG1461	Dihydroxyacetone kinase
AH4AK4_3942	COG2376	Dihydroxyacetone kinase
AH4AK4_3943	COG2252	PERMEase
AH4AK4_3944	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AH4AK4_3950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AH4AK4_3951	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AH4AK4_3952	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AH4AK4_3953	COG0049	tRNA binding
AH4AK4_3954	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AH4AK4_3955	COG2168	tRNA wobble position uridine thiolation
AH4AK4_3959	COG2964	Protein conserved in bacteria
AH4AK4_3960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AH4AK4_3961	COG0085	RNA polymerase activity
AH4AK4_3962	COG0222	ribosome binding
AH4AK4_3963	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AH4AK4_3964	COG0081	regulation of translation
AH4AK4_3965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AH4AK4_3966	COG0250	Participates in transcription elongation, termination and antitermination
AH4AK4_3967	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AH4AK4_3969	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AH4AK4_3975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AH4AK4_3976	COG0569	domain protein
AH4AK4_3977	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_3978	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AH4AK4_3979	COG3005	denitrification pathway
AH4AK4_3980	COG0243	molybdopterin cofactor binding
AH4AK4_3982	COG2205	protein histidine kinase activity
AH4AK4_3983	COG0745	RESPONSE REGULATOR receiver
AH4AK4_3986	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AH4AK4_3987	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AH4AK4_3989	COG2204	response regulator
AH4AK4_3991	COG2205	protein histidine kinase activity
AH4AK4_3995	COG0516	GMP reductase activity
AH4AK4_3995	COG0517	IMP dehydrogenase activity
AH4AK4_3996	COG5413	integral membrane protein
AH4AK4_3998	COG1522	sequence-specific DNA binding
AH4AK4_3999	COG2502	aspartate--ammonia ligase
AH4AK4_4000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AH4AK4_4001	COG0542	response to heat
AH4AK4_4003	COG0564	pseudouridine synthase activity
AH4AK4_4004	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_4005	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_4007	COG3681	Belongs to the UPF0597 family
AH4AK4_4008	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AH4AK4_4009	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AH4AK4_4010	COG1979	alcohol dehydrogenase
AH4AK4_4011	COG2207	Transcriptional regulator
AH4AK4_4012	COG3040	lipid binding
AH4AK4_4014	COG0840	transmembrane signaling receptor activity
AH4AK4_4015	COG0688	phosphatidylethanolamine metabolic process
AH4AK4_4019	COG0540	Belongs to the ATCase OTCase family
AH4AK4_4020	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AH4AK4_4021	COG1438	arginine binding
AH4AK4_4022	COG1288	antiporter activity
AH4AK4_4023	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AH4AK4_4029	COG4211	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_4030	COG1129	ABC transporter
AH4AK4_4032	COG3250	beta-galactosidase activity
AH4AK4_4033	COG1609	Transcriptional regulator
AH4AK4_4034	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH4AK4_4036	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AH4AK4_4037	COG2017	converts alpha-aldose to the beta-anomer
AH4AK4_4039	COG2211	Major facilitator Superfamily
AH4AK4_4041	COG1609	Transcriptional regulator
AH4AK4_4044	COG1175	transmembrane transport
AH4AK4_4048	COG4580	involved in the transport of maltose and maltodextrins
AH4AK4_4049	COG0667	Aldo Keto reductase
AH4AK4_4050	COG1968	undecaprenyl-diphosphatase activity
AH4AK4_4051	COG3806	Anti-sigma factor
AH4AK4_4052	COG1595	DNA-templated transcription, initiation
AH4AK4_4054	COG0018	arginyl-trna synthetase
AH4AK4_4056	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AH4AK4_4057	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AH4AK4_4061	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_4062	COG1131	(ABC) transporter
AH4AK4_4063	COG0842	Transport permease protein
AH4AK4_4064	COG0842	Transport permease protein
AH4AK4_4067	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_4068	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_4069	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_4070	COG2116	formate transmembrane transporter activity
AH4AK4_4071	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AH4AK4_4071	COG1648	precorrin-2 dehydrogenase activity
AH4AK4_4073	COG2239	Acts as a magnesium transporter
AH4AK4_4074	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AH4AK4_4075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AH4AK4_4077	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AH4AK4_4079	COG0514	ATP-dependent DNA helicase (RecQ)
AH4AK4_4080	COG2050	protein possibly involved in aromatic compounds catabolism
AH4AK4_4083	COG2258	MOSC domain
AH4AK4_4084	COG1177	transmembrane transport
AH4AK4_4085	COG1176	ABC-type spermidine putrescine transport system, permease component I
AH4AK4_4086	COG3842	ATPase activity
AH4AK4_4092	COG0174	glutamine synthetase
AH4AK4_4093	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AH4AK4_4096	COG3045	CreA protein
AH4AK4_4097	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AH4AK4_4098	COG0443	Heat shock 70 kDa protein
AH4AK4_4101	COG0366	Alpha amylase catalytic
AH4AK4_4104	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_4105	COG0745	RESPONSE REGULATOR receiver
AH4AK4_4106	COG2205	protein histidine kinase activity
AH4AK4_4108	COG0281	malic enzyme
AH4AK4_4109	COG0702	epimerase
AH4AK4_4110	COG0254	rRNA binding
AH4AK4_4111	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AH4AK4_4114	COG0129	dihydroxy-acid dehydratase activity
AH4AK4_4115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AH4AK4_4116	COG3978	acetolactate synthase activity
AH4AK4_4118	COG0606	chelatase, subunit chli
AH4AK4_4119	COG0204	Acyl-transferase
AH4AK4_4120	COG0204	Acyl-transferase
AH4AK4_4122	COG1335	isochorismatase
AH4AK4_4124	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AH4AK4_4125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AH4AK4_4127	COG3084	Protein conserved in bacteria
AH4AK4_4128	COG4251	negative regulation of phosphorylation
AH4AK4_4128	COG3706	GGDEF domain
AH4AK4_4128	COG2203	Gaf domain
AH4AK4_4128	COG5001	Diguanylate cyclase
AH4AK4_4129	COG0789	Transcriptional regulator
AH4AK4_4131	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AH4AK4_4132	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AH4AK4_4133	COG1561	YicC-like family, N-terminal region
AH4AK4_4135	COG1519	Transferase
AH4AK4_4136	COG0859	PFAM glycosyl transferase family 9
AH4AK4_4137	COG0463	Glycosyl transferase, family 2
AH4AK4_4138	COG0859	PFAM glycosyl transferase family 9
AH4AK4_4139	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AH4AK4_4140	COG2990	Protein conserved in bacteria
AH4AK4_4141	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AH4AK4_4143	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AH4AK4_4144	COG2003	Belongs to the UPF0758 family
AH4AK4_4145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AH4AK4_4146	COG0756	dUTP diphosphatase activity
AH4AK4_4147	COG1309	transcriptional regulator
AH4AK4_4148	COG0668	transmembrane transport
AH4AK4_4149	COG0166	Belongs to the GPI family
AH4AK4_4150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AH4AK4_4151	COG0583	DNA-binding transcription factor activity
AH4AK4_4153	COG0045	succinate-CoA ligase (ADP-forming) activity
AH4AK4_4153	COG1042	CoA-binding domain protein
AH4AK4_4153	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_4159	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AH4AK4_4160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_4161	COG1739	Uncharacterized protein family UPF0029
AH4AK4_4162	COG0006	proline dipeptidase activity
AH4AK4_4163	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AH4AK4_4164	COG1024	Enoyl-CoA hydratase
AH4AK4_4164	COG1250	3-hydroxyacyl-CoA dehydrogenase
AH4AK4_4165	COG0183	Belongs to the thiolase family
AH4AK4_4166	COG0745	RESPONSE REGULATOR receiver
AH4AK4_4171	COG0425	Belongs to the sulfur carrier protein TusA family
AH4AK4_4172	COG0251	oxidation-reduction process
AH4AK4_4173	COG2885	chlorophyll binding
AH4AK4_4178	COG2818	Glycosylase
AH4AK4_4179	COG0752	glycyl-tRNA synthetase alpha subunit
AH4AK4_4180	COG0751	glycine-tRNA ligase activity
AH4AK4_4184	COG0640	Transcriptional regulator
AH4AK4_4186	COG0814	amino acid
AH4AK4_4187	COG0814	amino acid
AH4AK4_4191	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_4192	COG0426	domain, Protein
AH4AK4_4192	COG1773	rubredoxin
AH4AK4_4193	COG3604	Transcriptional regulator
AH4AK4_4194	COG1609	Transcriptional regulator
AH4AK4_4196	COG0559	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_4202	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_4205	COG2960	long-chain fatty acid transporting porin activity
AH4AK4_4207	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AH4AK4_4209	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AH4AK4_4210	COG3118	belongs to the thioredoxin family
AH4AK4_4211	COG0513	Belongs to the DEAD box helicase family
AH4AK4_4212	COG0248	Ppx GppA phosphatase
AH4AK4_4215	COG0742	ribosomal rna small subunit methyltransferase
AH4AK4_4220	COG0084	hydrolase, TatD family'
AH4AK4_4221	COG0805	protein transport
AH4AK4_4222	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_4223	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_4224	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AH4AK4_4225	COG3165	ubiquinone biosynthetic process from chorismate
AH4AK4_4227	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AH4AK4_4228	COG0402	S-adenosylhomocysteine deaminase activity
AH4AK4_4236	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AH4AK4_4237	COG0848	biopolymer transport protein
AH4AK4_4238	COG0811	peptide transport
AH4AK4_4239	COG0811	peptide transport
AH4AK4_4241	COG2771	luxR family
AH4AK4_4242	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AH4AK4_4243	COG1349	DNA-binding transcription factor activity
AH4AK4_4244	COG0745	RESPONSE REGULATOR receiver
AH4AK4_4245	COG2205	protein histidine kinase activity
AH4AK4_4247	COG4452	Inner membrane protein CreD
AH4AK4_4248	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AH4AK4_4249	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AH4AK4_4250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AH4AK4_4251	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AH4AK4_4252	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AH4AK4_4253	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AH4AK4_4254	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AH4AK4_4256	COG0356	it plays a direct role in the translocation of protons across the membrane
AH4AK4_4257	COG1475	DNA binding
AH4AK4_4258	COG1192	Involved in chromosome partitioning
AH4AK4_4259	COG0357	Ribosomal RNA small subunit methyltransferase G
AH4AK4_4260	COG0445	tRNA wobble uridine modification
AH4AK4_4261	COG0716	FMN binding
AH4AK4_4262	COG4774	siderophore transport
AH4AK4_4263	COG4615	Cyclic peptide transporter
AH4AK4_4264	COG1120	ATPase activity
AH4AK4_4265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AH4AK4_4267	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AH4AK4_4268	COG0706	membrane insertase activity
AH4AK4_4269	COG0594	ribonuclease P activity