locus-tag	class	description
LEO74_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEO74_00010	COG0592	DNA-directed DNA polymerase activity
LEO74_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEO74_00030	COG2378	regulation of single-species biofilm formation
LEO74_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO74_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO74_00045	COG3977	Valine--pyruvate aminotransferase
LEO74_00060	COG2814	Major facilitator Superfamily
LEO74_00065	COG0745	RESPONSE REGULATOR receiver
LEO74_00070	COG2205	protein histidine kinase activity
LEO74_00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO74_00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_00095	COG4191	Histidine kinase
LEO74_00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_00110	COG1309	transcriptional regulator
LEO74_00140	COG0469	pyruvate kinase activity
LEO74_00145	COG2271	Major facilitator Superfamily
LEO74_00170	COG0561	phosphatase activity
LEO74_00175	COG2267	carboxylic ester hydrolase activity
LEO74_00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO74_00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO74_00190	COG1758	RNA polymerase activity
LEO74_00200	COG0859	PFAM glycosyl transferase family 9
LEO74_00205	COG3642	lipopolysaccharide core region biosynthetic process
LEO74_00245	COG0589	response to stress
LEO74_00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO74_00260	COG1528	Iron-storage protein
LEO74_00265	COG2081	HI0933 family
LEO74_00270	COG2223	nitrite transmembrane transporter activity
LEO74_00290	COG3188	usher protein
LEO74_00310	COG2205	protein histidine kinase activity
LEO74_00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_00320	COG3275	phosphorelay sensor kinase activity
LEO74_00325	COG3279	Response regulator of the LytR AlgR family
LEO74_00330	COG2223	nitrite transmembrane transporter activity
LEO74_00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEO74_00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEO74_00355	COG0583	DNA-binding transcription factor activity
LEO74_00360	COG4206	TonB-dependent receptor
LEO74_00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEO74_00400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEO74_00405	COG2166	iron-sulfur cluster assembly
LEO74_00410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO74_00415	COG0210	DNA helicase
LEO74_00425	COG3245	cytochrome
LEO74_00430	COG1063	alcohol dehydrogenase
LEO74_00435	COG0156	8-amino-7-oxononanoate synthase activity
LEO74_00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO74_00460	COG3306	glycosyltransferase involved in LPS biosynthesis
LEO74_00480	COG1561	YicC-like family, N-terminal region
LEO74_00485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEO74_00490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEO74_00500	COG0789	Transcriptional regulator
LEO74_00505	COG4251	negative regulation of phosphorylation
LEO74_00505	COG3706	GGDEF domain
LEO74_00505	COG2203	Gaf domain
LEO74_00505	COG5001	Diguanylate cyclase
LEO74_00510	COG3084	Protein conserved in bacteria
LEO74_00520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEO74_00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO74_00535	COG1335	isochorismatase
LEO74_00545	COG1683	Conserved Protein
LEO74_00550	COG0204	Acyl-transferase
LEO74_00555	COG0204	Acyl-transferase
LEO74_00560	COG0606	chelatase, subunit chli
LEO74_00570	COG3978	acetolactate synthase activity
LEO74_00580	COG0129	dihydroxy-acid dehydratase activity
LEO74_00600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEO74_00605	COG0254	rRNA binding
LEO74_00610	COG0702	epimerase
LEO74_00615	COG0281	malic enzyme
LEO74_00625	COG2205	protein histidine kinase activity
LEO74_00630	COG0745	RESPONSE REGULATOR receiver
LEO74_00635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO74_00650	COG0366	Alpha amylase catalytic
LEO74_00665	COG0443	Heat shock 70 kDa protein
LEO74_00670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO74_00675	COG3045	CreA protein
LEO74_00695	COG0174	glutamine synthetase
LEO74_00715	COG3842	ATPase activity
LEO74_00720	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO74_00725	COG1177	transmembrane transport
LEO74_00730	COG2258	MOSC domain
LEO74_00745	COG2050	protein possibly involved in aromatic compounds catabolism
LEO74_00750	COG0514	ATP-dependent DNA helicase (RecQ)
LEO74_00760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEO74_00770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEO74_00775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO74_00785	COG2239	Acts as a magnesium transporter
LEO74_00790	COG1648	precorrin-2 dehydrogenase activity
LEO74_00790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO74_00795	COG2116	formate transmembrane transporter activity
LEO74_00805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO74_00810	COG0842	Transport permease protein
LEO74_00815	COG0842	Transport permease protein
LEO74_00820	COG1131	(ABC) transporter
LEO74_00830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LEO74_00835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LEO74_00855	COG1595	DNA-templated transcription, initiation
LEO74_00860	COG3806	Anti-sigma factor
LEO74_00865	COG1968	undecaprenyl-diphosphatase activity
LEO74_00870	COG0667	Aldo Keto reductase
LEO74_00875	COG2017	converts alpha-aldose to the beta-anomer
LEO74_00880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO74_00890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO74_00895	COG1609	Transcriptional regulator
LEO74_00900	COG3250	beta-galactosidase activity
LEO74_00920	COG0840	transmembrane signaling receptor activity
LEO74_00950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO74_00955	COG1288	antiporter activity
LEO74_00960	COG1438	arginine binding
LEO74_00965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEO74_00970	COG0540	Belongs to the ATCase OTCase family
LEO74_00990	COG0688	phosphatidylethanolamine metabolic process
LEO74_01000	COG3040	lipid binding
LEO74_01005	COG2207	Transcriptional regulator
LEO74_01010	COG1979	alcohol dehydrogenase
LEO74_01015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEO74_01020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEO74_01030	COG3681	Belongs to the UPF0597 family
LEO74_01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO74_01045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO74_01050	COG0564	pseudouridine synthase activity
LEO74_01060	COG0542	response to heat
LEO74_01065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO74_01070	COG2502	aspartate--ammonia ligase
LEO74_01075	COG1522	sequence-specific DNA binding
LEO74_01085	COG5413	integral membrane protein
LEO74_01110	COG2205	protein histidine kinase activity
LEO74_01120	COG2204	response regulator
LEO74_01135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LEO74_01165	COG0243	molybdopterin cofactor binding
LEO74_01170	COG3005	denitrification pathway
LEO74_01175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEO74_01195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO74_01200	COG0569	domain protein
LEO74_01205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEO74_01230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO74_01245	COG0250	Participates in transcription elongation, termination and antitermination
LEO74_01250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEO74_01255	COG0081	regulation of translation
LEO74_01260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEO74_01265	COG0222	ribosome binding
LEO74_01270	COG0085	RNA polymerase activity
LEO74_01275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEO74_01280	COG2964	Protein conserved in bacteria
LEO74_01285	COG0251	oxidation-reduction process
LEO74_01295	COG2923	Belongs to the DsrF TusC family
LEO74_01300	COG2168	tRNA wobble position uridine thiolation
LEO74_01305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEO74_01310	COG0049	tRNA binding
LEO74_01315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEO74_01320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO74_01325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO74_01360	COG2252	PERMEase
LEO74_01365	COG2376	Dihydroxyacetone kinase
LEO74_01370	COG1461	Dihydroxyacetone kinase
LEO74_01385	COG3284	Transcriptional regulator
LEO74_01390	COG0583	DNA-binding transcription factor activity
LEO74_01395	COG2957	Belongs to the agmatine deiminase family
LEO74_01410	COG0628	permease
LEO74_01415	COG0494	nUDIX hydrolase
LEO74_01440	COG0753	catalase activity
LEO74_01445	COG1247	-acetyltransferase
LEO74_01465	COG2203	Gaf domain
LEO74_01465	COG2199	diguanylate cyclase activity
LEO74_01475	COG3842	ATPase activity
LEO74_01485	COG1175	transmembrane transport
LEO74_01510	COG0583	DNA-binding transcription factor activity
LEO74_01520	COG1741	Belongs to the pirin family
LEO74_01525	COG2259	Doxx family
LEO74_01530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LEO74_01535	COG1074	ATP-dependent DNA helicase activity
LEO74_01540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO74_01550	COG0346	lactoylglutathione lyase activity
LEO74_01595	COG4251	negative regulation of phosphorylation
LEO74_01595	COG2203	Gaf domain
LEO74_01595	COG3706	GGDEF domain
LEO74_01595	COG5001	Diguanylate cyclase
LEO74_01600	COG4771	TonB-dependent receptor
LEO74_01605	COG1278	Cold shock
LEO74_01630	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO74_01635	COG5499	transcription regulator containing HTH domain
LEO74_01650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LEO74_01665	COG1136	(ABC) transporter
LEO74_01680	COG1309	transcriptional regulator
LEO74_01685	COG5642	Protein of unknown function (DUF2384)
LEO74_01715	COG0629	single-stranded DNA binding
LEO74_01720	COG2197	response regulator
LEO74_01725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEO74_01735	COG3047	cAMP biosynthetic process
LEO74_01765	COG3135	benzoate transporter
LEO74_01770	COG1396	sequence-specific DNA binding
LEO74_01800	COG2926	Belongs to the UPF0265 family
LEO74_01810	COG3028	Belongs to the UPF0307 family
LEO74_01815	COG0312	modulator of DNA gyrase
LEO74_01820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEO74_01825	COG5007	Belongs to the BolA IbaG family
LEO74_01835	COG2854	intermembrane phospholipid transfer
LEO74_01840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO74_01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEO74_01850	COG1127	ABC transporter
LEO74_01855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO74_01855	COG0517	IMP dehydrogenase activity
LEO74_01860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEO74_01865	COG3117	lipopolysaccharide transmembrane transporter activity
LEO74_01870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LEO74_01875	COG1137	ATPase activity
LEO74_01880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LEO74_01890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_01895	COG1660	Displays ATPase and GTPase activities
LEO74_01900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_01905	COG3711	transcriptional antiterminator
LEO74_01905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_01920	COG3964	amidohydrolase
LEO74_01950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO74_01955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO74_01965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LEO74_01970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEO74_01975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEO74_01980	COG0723	plastoquinol--plastocyanin reductase activity
LEO74_01985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEO74_01990	COG2857	Cytochrome c1
LEO74_01995	COG0625	glutathione transferase activity
LEO74_02000	COG2969	positive regulation of protein catabolic process
LEO74_02005	COG2823	Periplasmic or secreted lipoprotein
LEO74_02010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO74_02015	COG0792	nuclease activity
LEO74_02020	COG3107	peptidoglycan biosynthetic process
LEO74_02025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEO74_02035	COG2001	Belongs to the MraZ family
LEO74_02040	COG0275	rRNA processing
LEO74_02045	COG3116	cell division
LEO74_02050	COG0768	penicillin binding
LEO74_02060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEO74_02065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO74_02070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEO74_02075	COG0772	Belongs to the SEDS family
LEO74_02080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO74_02085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO74_02090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LEO74_02095	COG0849	cell division
LEO74_02100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEO74_02105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEO74_02115	COG0653	protein targeting
LEO74_02125	COG0494	nUDIX hydrolase
LEO74_02130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LEO74_02135	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LEO74_02150	COG1459	type II secretion system
LEO74_02155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO74_02180	COG2186	Transcriptional regulator
LEO74_02185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LEO74_02190	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO74_02195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO74_02205	COG0840	transmembrane signaling receptor activity
LEO74_02210	COG0840	transmembrane signaling receptor activity
LEO74_02215	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO74_02220	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEO74_02225	COG2200	EAL domain
LEO74_02235	COG1280	lysine exporter protein (LysE YggA)
LEO74_02245	COG0523	cobalamin synthesis protein
LEO74_02250	COG0477	Major facilitator Superfamily
LEO74_02265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEO74_02270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEO74_02315	COG0784	Response regulator, receiver
LEO74_02315	COG0835	chemotaxis
LEO74_02320	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_02325	COG1444	tRNA N-acetyltransferase activity
LEO74_02350	COG1803	Methylglyoxal synthase
LEO74_02365	COG0252	asparaginase activity
LEO74_02385	COG1263	PTS System
LEO74_02385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_02390	COG0366	Alpha amylase catalytic
LEO74_02395	COG0110	maltose O-acetyltransferase activity
LEO74_02400	COG1522	sequence-specific DNA binding
LEO74_02405	COG5006	permease, DMT superfamily
LEO74_02415	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_02420	COG1177	transmembrane transport
LEO74_02425	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO74_02430	COG3842	ATPase activity
LEO74_02435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEO74_02440	COG0583	DNA-binding transcription factor activity
LEO74_02445	COG1757	Na H antiporter
LEO74_02485	COG0297	glycogen (starch) synthase activity
LEO74_02490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO74_02495	COG2813	Specifically methylates the guanine in position
LEO74_02500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO74_02505	COG3706	GGDEF domain
LEO74_02505	COG4251	negative regulation of phosphorylation
LEO74_02505	COG5001	Diguanylate cyclase
LEO74_02505	COG2203	Gaf domain
LEO74_02515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO74_02525	COG2995	paraquat-inducible protein a
LEO74_02530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO74_02530	COG3008	intermembrane lipid transfer
LEO74_02535	COG3009	Protein conserved in bacteria
LEO74_02540	COG2885	chlorophyll binding
LEO74_02540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LEO74_02550	COG3240	lipase activity
LEO74_02555	COG3111	PFAM Bacterial OB fold (BOF) protein
LEO74_02565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LEO74_02570	COG1194	a g-specific adenine glycosylase
LEO74_02580	COG3267	Type II secretory pathway component ExeA
LEO74_02580	COG3409	Peptidoglycan-binding domain 1 protein
LEO74_02585	COG0617	tRNA 3'-terminal CCA addition
LEO74_02600	COG1346	cytolysis
LEO74_02605	COG1380	Effector of murein hydrolase LrgA
LEO74_02610	COG0583	DNA-binding transcription factor activity
LEO74_02640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEO74_02645	COG0306	phosphate transporter
LEO74_02650	COG1392	Phosphate transport regulator
LEO74_02665	COG1560	Kdo2-lipid A biosynthetic process
LEO74_02670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEO74_02670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEO74_02675	COG1538	Outer membrane efflux protein
LEO74_02680	COG0494	nUDIX hydrolase
LEO74_02685	COG3151	Protein conserved in bacteria
LEO74_02695	COG3150	esterase
LEO74_02700	COG1051	belongs to the nudix hydrolase family
LEO74_02715	COG1566	PFAM secretion protein HlyD family protein
LEO74_02720	COG1289	transmembrane transporter activity
LEO74_02745	COG0583	DNA-binding transcription factor activity
LEO74_02790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO74_02815	COG0204	Acyl-transferase
LEO74_02820	COG1842	Phage shock protein A
LEO74_02835	COG2827	Endonuclease containing a URI domain
LEO74_02845	COG2962	Rard protein
LEO74_02850	COG1573	uracil-dna glycosylase
LEO74_02855	COG0697	spore germination
LEO74_02860	COG0583	DNA-binding transcription factor activity
LEO74_02865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEO74_02870	COG1121	(ABC) transporter
LEO74_02875	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LEO74_02895	COG0739	heme binding
LEO74_02905	COG3068	Protein conserved in bacteria
LEO74_02925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEO74_02930	COG1546	Belongs to the CinA family
LEO74_02935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEO74_02945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO74_02950	COG0527	aspartate kinase activity
LEO74_02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LEO74_02995	COG1686	Belongs to the peptidase S11 family
LEO74_03000	COG0586	Pfam SNARE associated Golgi protein
LEO74_03005	COG1253	flavin adenine dinucleotide binding
LEO74_03010	COG0525	valine-tRNA ligase activity
LEO74_03015	COG2927	DNA polymerase III (CHI subunit)
LEO74_03020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO74_03025	COG0795	lipopolysaccharide-transporting ATPase activity
LEO74_03030	COG0795	lipopolysaccharide-transporting ATPase activity
LEO74_03045	COG0582	viral genome integration into host DNA
LEO74_03105	COG0004	ammonium transporteR
LEO74_03110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO74_03120	COG2165	general secretion pathway protein
LEO74_03125	COG0084	hydrolase, TatD family'
LEO74_03130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO74_03140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO74_03145	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LEO74_03150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEO74_03155	COG0813	purine-nucleoside phosphorylase activity
LEO74_03160	COG5002	protein histidine kinase activity
LEO74_03160	COG5001	Diguanylate cyclase
LEO74_03160	COG3447	MASE1 domain protein
LEO74_03170	COG0560	Phosphoserine phosphatase
LEO74_03195	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LEO74_03205	COG0776	regulation of translation
LEO74_03220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO74_03225	COG0735	belongs to the Fur family
LEO74_03250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEO74_03255	COG0513	Belongs to the DEAD box helicase family
LEO74_03260	COG3022	response to hydroperoxide
LEO74_03275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEO74_03280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEO74_03285	COG0762	integral membrane protein
LEO74_03290	COG1872	DUF167
LEO74_03305	COG4166	transmembrane transport
LEO74_03325	COG1024	Enoyl-CoA hydratase
LEO74_03340	COG4221	oxidoreductase activity
LEO74_03345	COG0442	prolyl-tRNA aminoacylation
LEO74_03350	COG0840	transmembrane signaling receptor activity
LEO74_03355	COG0632	four-way junction helicase activity
LEO74_03360	COG2255	four-way junction helicase activity
LEO74_03365	COG1271	oxidase subunit
LEO74_03370	COG1294	oxidase, subunit
LEO74_03375	COG4890	Cyd operon protein YbgT
LEO74_03380	COG3790	cyd operon protein YbgE
LEO74_03385	COG0824	Thioesterase
LEO74_03390	COG0811	peptide transport
LEO74_03405	COG0823	Involved in the tonB-independent uptake of proteins
LEO74_03410	COG2885	chlorophyll binding
LEO74_03415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LEO74_03490	COG0840	transmembrane signaling receptor activity
LEO74_03495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEO74_03500	COG0676	glucose-6-phosphate 1-epimerase activity
LEO74_03505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO74_03510	COG1640	4-alpha-glucanotransferase
LEO74_03515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEO74_03535	COG1051	belongs to the nudix hydrolase family
LEO74_03540	COG2130	NADP-dependent
LEO74_03545	COG1764	response to oxidative stress
LEO74_03550	COG1846	Transcriptional regulator
LEO74_03585	COG0561	phosphatase activity
LEO74_03600	COG0733	neurotransmitter:sodium symporter activity
LEO74_03610	COG0733	neurotransmitter:sodium symporter activity
LEO74_03635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO74_03650	COG1794	racemase activity, acting on amino acids and derivatives
LEO74_03665	COG2731	YhcH YjgK YiaL family protein
LEO74_03675	COG0668	transmembrane transport
LEO74_03685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO74_03715	COG0583	DNA-binding transcription factor activity
LEO74_03720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LEO74_03730	COG0488	(ABC) transporter
LEO74_03735	COG0517	IMP dehydrogenase activity
LEO74_03735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO74_03740	COG1585	Membrane protein implicated in regulation of membrane protease activity
LEO74_03745	COG0330	HflC and HflK could
LEO74_03750	COG1648	precorrin-2 dehydrogenase activity
LEO74_03750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO74_03755	COG0175	sulfate reduction
LEO74_03760	COG2895	sulfate adenylyltransferase (ATP) activity
LEO74_03765	COG3273	potassium ion transport
LEO74_03765	COG0471	metal ion transport
LEO74_03770	COG0529	Catalyzes the synthesis of activated sulfate
LEO74_03805	COG0840	transmembrane signaling receptor activity
LEO74_03825	COG1136	(ABC) transporter
LEO74_03840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LEO74_03855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEO74_03860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO74_03865	COG0163	prenyltransferase activity
LEO74_03880	COG1131	(ABC) transporter
LEO74_03885	COG0842	Transport permease protein
LEO74_03890	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LEO74_03895	COG1924	4 iron, 4 sulfur cluster binding
LEO74_03915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEO74_03920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEO74_03935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO74_03940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LEO74_03945	COG1489	DNA binding
LEO74_03955	COG1643	Atp-dependent helicase
LEO74_03960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO74_03965	COG0346	lactoylglutathione lyase activity
LEO74_03975	COG2076	Multidrug Resistance protein
LEO74_03985	COG3437	response regulator, receiver
LEO74_03985	COG0784	Response regulator, receiver
LEO74_03995	COG0671	phosphoesterase, PA-phosphatase related
LEO74_04010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEO74_04015	COG0038	chloride channel
LEO74_04025	COG0316	Belongs to the HesB IscA family
LEO74_04050	COG1280	lysine exporter protein (LysE YggA)
LEO74_04055	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LEO74_04070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_04100	COG0745	RESPONSE REGULATOR receiver
LEO74_04105	COG3104	oligopeptide transport
LEO74_04110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEO74_04115	COG1555	photosystem II stabilization
LEO74_04125	COG2350	Protein conserved in bacteria
LEO74_04130	COG2917	probably involved in intracellular septation
LEO74_04135	COG0076	glutamate decarboxylase activity
LEO74_04140	COG1272	protein, Hemolysin III
LEO74_04145	COG2985	domain, Protein
LEO74_04145	COG0569	domain protein
LEO74_04160	COG0784	Response regulator, receiver
LEO74_04160	COG0835	chemotaxis
LEO74_04165	COG2755	lipolytic protein G-D-S-L family
LEO74_04170	COG4181	ATPase activity
LEO74_04175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LEO74_04180	COG1090	epimerase
LEO74_04185	COG2200	EAL domain
LEO74_04190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO74_04195	COG4935	Belongs to the peptidase S8 family
LEO74_04195	COG2234	aminopeptidase activity
LEO74_04200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEO74_04205	COG3171	Protein conserved in bacteria
LEO74_04210	COG2066	Belongs to the glutaminase family
LEO74_04215	COG2897	thiosulfate sulfurtransferase activity
LEO74_04225	COG1132	(ABC) transporter
LEO74_04245	COG0582	viral genome integration into host DNA
LEO74_04265	COG4974	Belongs to the 'phage' integrase family
LEO74_04300	COG0783	Belongs to the Dps family
LEO74_04310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO74_04315	COG5433	transposase activity
LEO74_04330	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO74_04345	COG1342	Belongs to the UPF0251 family
LEO74_04355	COG0582	viral genome integration into host DNA
LEO74_04385	COG4974	Belongs to the 'phage' integrase family
LEO74_04430	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LEO74_04435	COG5001	Diguanylate cyclase
LEO74_04435	COG3300	MHYT domain
LEO74_04445	COG2207	Transcriptional regulator
LEO74_04450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO74_04455	COG3059	membrane
LEO74_04475	COG4628	conserved protein (DUF2132)
LEO74_04480	COG0688	phosphatidylethanolamine metabolic process
LEO74_04485	COG1162	GTPase activity
LEO74_04490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LEO74_04530	COG1278	Cold shock
LEO74_04540	COG0840	transmembrane signaling receptor activity
LEO74_04545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO74_04595	COG0848	biopolymer transport protein
LEO74_04600	COG0811	peptide transport
LEO74_04605	COG0811	peptide transport
LEO74_04620	COG4174	ABC transporter (Permease)
LEO74_04625	COG4239	(ABC) transporter, permease
LEO74_04635	COG0444	Belongs to the ABC transporter superfamily
LEO74_04640	COG4608	Belongs to the ABC transporter superfamily
LEO74_04645	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO74_04650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LEO74_04655	COG1073	alpha beta
LEO74_04670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEO74_04695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO74_04700	COG2313	pseudouridylate synthase activity
LEO74_04710	COG1858	cytochrome C peroxidase
LEO74_04745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO74_04750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO74_04810	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_04815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO74_04825	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO74_04835	COG2966	Psort location CytoplasmicMembrane, score
LEO74_04840	COG3610	response to peptide
LEO74_04850	COG4175	Glycine betaine
LEO74_04855	COG4176	ABC-type proline glycine betaine transport system permease component
LEO74_04860	COG2113	Glycine betaine
LEO74_04865	COG0175	sulfate reduction
LEO74_04870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO74_04875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO74_04880	COG0384	phenazine biosynthesis protein PhzF
LEO74_04885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEO74_04900	COG0786	glutamate:sodium symporter activity
LEO74_04905	COG0252	asparaginase activity
LEO74_04910	COG3139	Protein of unknown function (DUF1315)
LEO74_04930	COG0616	signal peptide processing
LEO74_04935	COG1902	pentaerythritol trinitrate reductase activity
LEO74_04935	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO74_04940	COG0778	Nitroreductase
LEO74_04965	COG2264	protein methyltransferase activity
LEO74_04970	COG0604	alcohol dehydrogenase
LEO74_04975	COG0583	DNA-binding transcription factor activity
LEO74_04980	COG1263	PTS System
LEO74_04980	COG2190	(PTS) system
LEO74_04980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_04985	COG4145	pantothenate transmembrane transporter activity
LEO74_04995	COG0439	Biotin carboxylase
LEO74_05000	COG0511	ligase activity, forming carbon-carbon bonds
LEO74_05005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEO74_05010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO74_05020	COG3300	MHYT domain
LEO74_05020	COG5001	Diguanylate cyclase
LEO74_05040	COG3381	protein complex oligomerization
LEO74_05055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEO74_05065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEO74_05070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO74_05070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO74_05090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEO74_05095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO74_05100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEO74_05105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LEO74_05110	COG4172	Belongs to the ABC transporter superfamily
LEO74_05120	COG0601	transmembrane transport
LEO74_05130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEO74_05135	COG0142	geranyltranstransferase activity
LEO74_05140	COG1722	exodeoxyribonuclease VII activity
LEO74_05145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO74_05150	COG1360	Flagellar Motor Protein
LEO74_05165	COG1534	Rna-binding protein
LEO74_05170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LEO74_05180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEO74_05185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO74_05190	COG0149	triose-phosphate isomerase activity
LEO74_05195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEO74_05210	COG0779	Required for maturation of 30S ribosomal subunits
LEO74_05215	COG0195	Participates in both transcription termination and antitermination
LEO74_05220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEO74_05225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEO74_05230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEO74_05235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEO74_05240	COG1185	polyribonucleotide nucleotidyltransferase activity
LEO74_05245	COG2211	Major facilitator Superfamily
LEO74_05255	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO74_05265	COG0114	fumarate hydratase activity
LEO74_05275	COG1966	Carbon starvation protein
LEO74_05280	COG3279	Response regulator of the LytR AlgR family
LEO74_05285	COG3275	phosphorelay sensor kinase activity
LEO74_05350	COG0312	modulator of DNA gyrase
LEO74_05355	COG0312	modulator of DNA gyrase
LEO74_05365	COG4974	Belongs to the 'phage' integrase family
LEO74_05375	COG1970	mechanosensitive ion channel activity
LEO74_05380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO74_05390	COG0789	Transcriptional regulator
LEO74_05405	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO74_05410	COG3545	Serine hydrolase
LEO74_05420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEO74_05425	COG0321	lipoyl(octanoyl) transferase activity
LEO74_05430	COG2921	Belongs to the UPF0250 family
LEO74_05435	COG1686	Belongs to the peptidase S11 family
LEO74_05440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO74_05445	COG2951	lytic endotransglycosylase activity
LEO74_05455	COG0768	penicillin binding
LEO74_05460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEO74_05465	COG0799	negative regulation of ribosome biogenesis
LEO74_05470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEO74_05485	COG0495	leucyl-tRNA aminoacylation
LEO74_05490	COG2888	peptidyl-tyrosine sulfation
LEO74_05495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO74_05500	COG4535	Mg2 and Co2 transporter CorC
LEO74_05505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEO74_05510	COG1702	phosphate starvation-inducible protein PhoH
LEO74_05515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO74_05520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO74_05525	COG1335	isochorismatase
LEO74_05535	COG3706	GGDEF domain
LEO74_05550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO74_05570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO74_05580	COG3647	Membrane
LEO74_05585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEO74_05595	COG0516	GMP reductase activity
LEO74_05605	COG0642	Histidine kinase
LEO74_05645	COG3214	Protein conserved in bacteria
LEO74_05670	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO74_05675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEO74_05680	COG1053	succinate dehydrogenase
LEO74_05690	COG0584	glycerophosphoryl diester phosphodiesterase
LEO74_05695	COG1511	domain protein
LEO74_05695	COG3264	Mechanosensitive ion channel
LEO74_05705	COG0739	heme binding
LEO74_05720	COG0583	DNA-binding transcription factor activity
LEO74_05740	COG0583	DNA-binding transcription factor activity
LEO74_05745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEO74_05775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEO74_05780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEO74_05790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LEO74_05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEO74_05805	COG0180	Tryptophanyl-tRNA synthetase
LEO74_05820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEO74_05830	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_05840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO74_05850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO74_05850	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO74_05850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_05850	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO74_05860	COG0488	(ABC) transporter
LEO74_05870	COG0366	Alpha amylase catalytic
LEO74_05900	COG0471	metal ion transport
LEO74_05900	COG0490	domain, Protein
LEO74_05945	COG0012	GTP binding
LEO74_05950	COG0193	aminoacyl-tRNA hydrolase activity
LEO74_05955	COG0737	Belongs to the 5'-nucleotidase family
LEO74_05960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEO74_05970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEO74_05975	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LEO74_05980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEO74_05985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEO74_05990	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO74_06000	COG2912	Transglutaminase-like superfamily
LEO74_06005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEO74_06010	COG1301	dicarboxylic acid transport
LEO74_06020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEO74_06035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO74_06040	COG1115	amino acid carrier protein
LEO74_06055	COG0714	Associated with various cellular activities
LEO74_06065	COG3104	oligopeptide transport
LEO74_06070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEO74_06075	COG1678	Uncharacterized ACR, COG1678
LEO74_06085	COG0189	ligase activity
LEO74_06090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEO74_06100	COG3091	SprT-like family
LEO74_06110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEO74_06130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEO74_06135	COG0739	heme binding
LEO74_06140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO74_06145	COG3408	Glycogen debranching enzyme
LEO74_06145	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LEO74_06155	COG1881	PFAM PEBP family protein
LEO74_06160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEO74_06165	COG0583	DNA-binding transcription factor activity
LEO74_06175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO74_06185	COG0583	DNA-binding transcription factor activity
LEO74_06190	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_06195	COG0616	signal peptide processing
LEO74_06200	COG3724	N-succinylarginine dihydrolase activity
LEO74_06220	COG0840	transmembrane signaling receptor activity
LEO74_06230	COG2971	BadF BadG BcrA BcrD
LEO74_06240	COG4608	Belongs to the ABC transporter superfamily
LEO74_06245	COG0444	Belongs to the ABC transporter superfamily
LEO74_06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO74_06255	COG0601	transmembrane transport
LEO74_06260	COG4166	transmembrane transport
LEO74_06265	COG2205	protein histidine kinase activity
LEO74_06265	COG0784	Response regulator, receiver
LEO74_06295	COG3220	belongs to the UPF0276 family
LEO74_06325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO74_06330	COG1289	transmembrane transporter activity
LEO74_06335	COG0303	'Molybdopterin
LEO74_06340	COG0746	molybdenum cofactor guanylyltransferase activity
LEO74_06350	COG4662	Binding-protein-dependent transport system inner membrane component
LEO74_06360	COG2204	response regulator
LEO74_06365	COG3852	Histidine kinase
LEO74_06370	COG1910	domain protein
LEO74_06375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO74_06410	COG3383	formate dehydrogenase (NAD+) activity
LEO74_06410	COG3383	formate dehydrogenase (NAD+) activity
LEO74_06415	COG0437	4 iron, 4 sulfur cluster binding
LEO74_06430	COG0281	malic enzyme
LEO74_06450	COG2706	6-phosphogluconolactonase activity
LEO74_06520	COG3264	Mechanosensitive ion channel
LEO74_06520	COG1196	nuclear chromosome segregation
LEO74_06525	COG0469	pyruvate kinase activity
LEO74_06540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO74_06540	COG4651	solute:proton antiporter activity
LEO74_06550	COG2974	May be involved in recombination
LEO74_06560	COG0420	3'-5' exonuclease activity
LEO74_06565	COG0419	ATPase involved in DNA repair
LEO74_06575	COG3038	cytochrome b561
LEO74_06590	COG2190	(PTS) system
LEO74_06600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_06605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEO74_06610	COG0542	response to heat
LEO74_06625	COG1720	tRNA m6t6A37 methyltransferase activity
LEO74_06645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LEO74_06650	COG4988	ABC transporter
LEO74_06665	COG0745	RESPONSE REGULATOR receiver
LEO74_06675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO74_06690	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LEO74_06695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LEO74_06705	COG0083	homoserine kinase activity
LEO74_06710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO74_06715	COG4319	ketosteroid isomerase
LEO74_06720	COG0488	(ABC) transporter
LEO74_06745	COG0813	purine-nucleoside phosphorylase activity
LEO74_06760	COG2205	protein histidine kinase activity
LEO74_06760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_06765	COG3384	dioxygenase
LEO74_06775	COG1283	sodium-dependent phosphate transmembrane transporter activity
LEO74_06785	COG0531	amino acid
LEO74_06795	COG0531	amino acid
LEO74_06810	COG1396	sequence-specific DNA binding
LEO74_06810	COG1917	Cupin 2, conserved barrel domain protein
LEO74_06815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO74_06835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO74_06840	COG2375	cellular response to nickel ion
LEO74_06850	COG1136	(ABC) transporter
LEO74_06850	COG0577	efflux transmembrane transporter activity
LEO74_06855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_06865	COG1227	inorganic diphosphatase activity
LEO74_06870	COG0497	DNA recombination
LEO74_06875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEO74_06880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEO74_06885	COG0443	Heat shock 70 kDa protein
LEO74_06890	COG0484	heat shock protein binding
LEO74_06920	COG1285	pathogenesis
LEO74_06935	COG0640	Transcriptional regulator
LEO74_06965	COG0095	Lipoate-protein ligase
LEO74_06985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_06990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_07010	COG0708	Exodeoxyribonuclease III
LEO74_07025	COG2211	Major facilitator Superfamily
LEO74_07070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO74_07075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LEO74_07080	COG1845	cytochrome c oxidase, subunit III
LEO74_07085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LEO74_07090	COG0109	protoheme IX farnesyltransferase activity
LEO74_07095	COG2814	Major facilitator Superfamily
LEO74_07105	COG2175	clavaminate synthase activity
LEO74_07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEO74_07115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LEO74_07120	COG4521	taurine ABC transporter
LEO74_07130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO74_07170	COG0159	tryptophan synthase activity
LEO74_07175	COG0133	tryptophan synthase activity
LEO74_07180	COG0135	phosphoribosylanthranilate isomerase activity
LEO74_07180	COG0134	indole-3-glycerol-phosphate synthase activity
LEO74_07185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO74_07190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO74_07190	COG0512	Glutamine amidotransferase of anthranilate synthase
LEO74_07195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEO74_07205	COG0009	L-threonylcarbamoyladenylate synthase
LEO74_07215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEO74_07225	COG1946	Acyl-CoA thioesterase
LEO74_07240	COG1309	transcriptional regulator
LEO74_07245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_07250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_07260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LEO74_07290	COG0482	sulfurtransferase activity
LEO74_07295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO74_07305	COG1086	Polysaccharide biosynthesis protein
LEO74_07330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO74_07345	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEO74_07350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LEO74_07360	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LEO74_07370	COG3132	Protein of unknown function, DUF480
LEO74_07410	COG1278	Cold shock
LEO74_07445	COG1349	DNA-binding transcription factor activity
LEO74_07450	COG1882	Formate acetyltransferase
LEO74_07455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO74_07460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO74_07490	COG0622	Phosphoesterase
LEO74_07505	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LEO74_07510	COG0784	Response regulator, receiver
LEO74_07510	COG0835	chemotaxis
LEO74_07515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEO74_07520	COG1815	bacterial-type flagellum-dependent cell motility
LEO74_07540	COG4787	bacterial-type flagellum-dependent cell motility
LEO74_07550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LEO74_07555	COG1706	bacterial-type flagellum-dependent cell motility
LEO74_07560	COG1705	Flagellar rod assembly protein muramidase FlgJ
LEO74_07560	COG3951	Flagellar rod assembly protein muramidase FlgJ
LEO74_07565	COG1256	bacterial-type flagellum assembly
LEO74_07575	COG2239	Acts as a magnesium transporter
LEO74_07585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEO74_07590	COG2716	regulation of RNA biosynthetic process
LEO74_07615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEO74_07620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEO74_07625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEO74_07630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEO74_07650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LEO74_07665	COG0590	tRNA wobble adenosine to inosine editing
LEO74_07670	COG0573	inorganic phosphate transmembrane transporter activity
LEO74_07675	COG0581	inorganic phosphate transmembrane transporter activity
LEO74_07680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEO74_07685	COG0704	Plays a role in the regulation of phosphate uptake
LEO74_07690	COG1253	flavin adenine dinucleotide binding
LEO74_07705	COG0531	amino acid
LEO74_07725	COG1126	abc transporter atp-binding protein
LEO74_07730	COG0765	amino acid transport
LEO74_07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_07740	COG3706	GGDEF domain
LEO74_07745	COG2271	Major facilitator Superfamily
LEO74_07760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO74_07785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEO74_07790	COG0477	Major facilitator Superfamily
LEO74_07795	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEO74_07805	COG1199	ATP-dependent helicase activity
LEO74_07820	COG1448	Aminotransferase
LEO74_07825	COG0433	COG0433 Predicted ATPase
LEO74_07840	COG2333	competence protein COMEC
LEO74_07840	COG0658	competence protein
LEO74_07845	COG1132	(ABC) transporter
LEO74_07850	COG1663	tetraacyldisaccharide 4'-kinase activity
LEO74_07855	COG2835	tetraacyldisaccharide 4'-kinase activity
LEO74_07860	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEO74_07865	COG2197	response regulator
LEO74_07870	COG0322	excinuclease ABC activity
LEO74_07925	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO74_07930	COG0437	4 iron, 4 sulfur cluster binding
LEO74_07935	COG3301	Polysulphide reductase, NrfD
LEO74_07940	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO74_07950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO74_07960	COG2801	Transposase and inactivated derivatives
LEO74_07985	COG2199	diguanylate cyclase activity
LEO74_07985	COG2203	Gaf domain
LEO74_08015	COG2119	membrane
LEO74_08020	COG0023	Translation Initiation Factor
LEO74_08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_08060	COG2205	protein histidine kinase activity
LEO74_08070	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LEO74_08080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO74_08085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEO74_08090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO74_08095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEO74_08100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEO74_08110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEO74_08115	COG0505	Belongs to the CarA family
LEO74_08120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEO74_08125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO74_08155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO74_08160	COG0513	Belongs to the DEAD box helicase family
LEO74_08170	COG4104	PAAR repeat-containing protein
LEO74_08185	COG0789	Transcriptional regulator
LEO74_08200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_08205	COG0765	amino acid transport
LEO74_08210	COG1126	abc transporter atp-binding protein
LEO74_08215	COG0493	'glutamate synthase
LEO74_08220	COG0067	glutamate synthase
LEO74_08220	COG0069	glutamate synthase activity
LEO74_08220	COG0070	glutamate synthase
LEO74_08225	COG1242	4 iron, 4 sulfur cluster binding
LEO74_08285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LEO74_08290	COG0574	Belongs to the PEP-utilizing enzyme family
LEO74_08290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO74_08325	COG1464	Belongs to the NlpA lipoprotein family
LEO74_08330	COG0671	phosphoesterase, PA-phosphatase related
LEO74_08335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO74_08340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO74_08350	COG0101	tRNA pseudouridine synthase activity
LEO74_08355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEO74_08360	COG0285	dihydrofolate synthase activity
LEO74_08365	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LEO74_08370	COG2920	part of a sulfur-relay system
LEO74_08375	COG1289	transmembrane transporter activity
LEO74_08380	COG0670	Belongs to the BI1 family
LEO74_08400	COG2194	sulfuric ester hydrolase activity
LEO74_08410	COG0392	lysyltransferase activity
LEO74_08410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEO74_08420	COG0840	transmembrane signaling receptor activity
LEO74_08425	COG5001	Diguanylate cyclase
LEO74_08430	COG0564	pseudouridine synthase activity
LEO74_08445	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LEO74_08455	COG0625	glutathione transferase activity
LEO74_08460	COG0625	glutathione transferase activity
LEO74_08470	COG0367	asparagine synthase
LEO74_08480	COG4651	solute:proton antiporter activity
LEO74_08480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO74_08485	COG0647	UMP catabolic process
LEO74_08495	COG1902	pentaerythritol trinitrate reductase activity
LEO74_08500	COG1253	flavin adenine dinucleotide binding
LEO74_08510	COG0247	lactate metabolic process
LEO74_08510	COG0277	FAD linked oxidase domain protein
LEO74_08520	COG2050	protein possibly involved in aromatic compounds catabolism
LEO74_08530	COG2056	Na+-H+ antiporter family
LEO74_08535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO74_08550	COG0346	lactoylglutathione lyase activity
LEO74_08555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEO74_08560	COG4660	Part of a membrane complex involved in electron transport
LEO74_08565	COG4659	FMN binding
LEO74_08570	COG4658	electron transport chain
LEO74_08580	COG2878	Part of a membrane complex involved in electron transport
LEO74_08585	COG4657	Part of a membrane complex involved in electron transport
LEO74_08590	COG0697	spore germination
LEO74_08605	COG2932	Transcriptional regulator
LEO74_08675	COG5566	PFAM Mor transcription activator
LEO74_08710	COG0640	Transcriptional regulator
LEO74_08720	COG4373	Mu-like prophage FluMu protein gp28
LEO74_08725	COG4383	Mu-like prophage protein gp29
LEO74_08755	COG4388	Caudovirus prohead serine protease
LEO74_08760	COG4397	Mu-like prophage major head subunit gpT
LEO74_08825	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO74_08830	COG1288	antiporter activity
LEO74_08835	COG0436	Aminotransferase
LEO74_08845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEO74_08850	COG2027	D-alanyl-D-alanine carboxypeptidase
LEO74_08855	COG1061	Type III restriction enzyme res subunit
LEO74_08860	COG1566	PFAM secretion protein HlyD family protein
LEO74_08870	COG1966	Carbon starvation protein
LEO74_08875	COG3279	Response regulator of the LytR AlgR family
LEO74_08880	COG3275	phosphorelay sensor kinase activity
LEO74_08885	COG2199	diguanylate cyclase activity
LEO74_08885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO74_08890	COG1454	alcohol dehydrogenase
LEO74_08890	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_08900	COG2095	MarC family integral membrane protein
LEO74_08910	COG0601	transmembrane transport
LEO74_08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO74_08930	COG0861	Integral membrane protein TerC family
LEO74_08935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO74_08945	COG1301	dicarboxylic acid transport
LEO74_08960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEO74_08975	COG0537	adenosine 5'-monophosphoramidase activity
LEO74_09010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO74_09015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO74_09025	COG2354	Protein conserved in bacteria
LEO74_09040	COG2233	PERMEase
LEO74_09045	COG3150	esterase
LEO74_09050	COG1252	NADH dehydrogenase
LEO74_09070	COG0393	Putative heavy-metal-binding
LEO74_09080	COG1648	precorrin-2 dehydrogenase activity
LEO74_09080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO74_09100	COG4667	esterase of the alpha-beta hydrolase superfamily
LEO74_09105	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEO74_09110	COG1368	sulfuric ester hydrolase activity
LEO74_09125	COG0527	aspartate kinase activity
LEO74_09130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO74_09130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEO74_09135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO74_09155	COG0596	Alpha beta hydrolase
LEO74_09160	COG0346	lactoylglutathione lyase activity
LEO74_09170	COG0583	DNA-binding transcription factor activity
LEO74_09175	COG1620	l-lactate permease
LEO74_09180	COG0247	lactate metabolic process
LEO74_09185	COG1139	Iron-sulfur cluster binding protein
LEO74_09215	COG0577	efflux transmembrane transporter activity
LEO74_09220	COG1136	(ABC) transporter
LEO74_09230	COG2814	Major facilitator Superfamily
LEO74_09250	COG0672	)-iron permease
LEO74_09280	COG0659	secondary active sulfate transmembrane transporter activity
LEO74_09300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO74_09305	COG0840	transmembrane signaling receptor activity
LEO74_09315	COG2201	protein-glutamate methylesterase activity
LEO74_09325	COG0835	chemotaxis
LEO74_09330	COG3290	protein histidine kinase activity
LEO74_09330	COG0840	transmembrane signaling receptor activity
LEO74_09335	COG2198	Histidine kinase
LEO74_09335	COG0643	Histidine kinase
LEO74_09350	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LEO74_09355	COG0437	4 iron, 4 sulfur cluster binding
LEO74_09360	COG5557	Pfam Polysulphide reductase, NrfD
LEO74_09365	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LEO74_09370	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO74_09375	COG1773	rubredoxin
LEO74_09390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO74_09400	COG3842	ATPase activity
LEO74_09405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEO74_09415	COG0375	protein maturation
LEO74_09420	COG0309	Hydrogenase expression formation protein (HypE)
LEO74_09430	COG0298	carbon dioxide binding
LEO74_09435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LEO74_09445	COG1921	L-seryl-tRNASec selenium transferase activity
LEO74_09455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO74_09465	COG3260	NADH ubiquinone oxidoreductase 20
LEO74_09470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_09475	COG3261	NADH dehydrogenase
LEO74_09475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LEO74_09480	COG0650	Formate hydrogenlyase subunit 4
LEO74_09485	COG0651	ATP synthesis coupled electron transport
LEO74_09490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_09495	COG3158	transport of potassium into the cell
LEO74_09500	COG2801	Transposase and inactivated derivatives
LEO74_09515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_09540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEO74_09545	COG0326	Molecular chaperone. Has ATPase activity
LEO74_09550	COG0563	adenylate kinase activity
LEO74_09555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEO74_09565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO74_09580	COG5001	Diguanylate cyclase
LEO74_09580	COG3300	MHYT domain
LEO74_09585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO74_09605	COG1021	2,3-dihydroxybenzoate-AMP ligase
LEO74_09610	COG1535	isochorismatase
LEO74_09610	COG3433	isochorismatase activity
LEO74_09615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO74_09620	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO74_09635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO74_09645	COG1120	ATPase activity
LEO74_09650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO74_09655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO74_09660	COG4771	TonB-dependent receptor
LEO74_09700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LEO74_09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEO74_09710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO74_09725	COG1570	exodeoxyribonuclease VII activity
LEO74_09730	COG0697	spore germination
LEO74_09750	COG3158	transport of potassium into the cell
LEO74_09755	COG0516	GMP reductase activity
LEO74_09755	COG0517	IMP dehydrogenase activity
LEO74_09760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO74_09760	COG0519	Catalyzes the synthesis of GMP from XMP
LEO74_09770	COG2801	Transposase and inactivated derivatives
LEO74_09805	COG2062	phosphohistidine phosphatase, SixA
LEO74_09815	COG0697	spore germination
LEO74_09820	COG4166	transmembrane transport
LEO74_09825	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEO74_09830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEO74_09840	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO74_09845	COG1136	(ABC) transporter
LEO74_09850	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO74_09855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LEO74_09865	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEO74_09870	COG0740	serine-type endopeptidase activity
LEO74_09875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEO74_09880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEO74_09885	COG0776	regulation of translation
LEO74_09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO74_09895	COG0488	(ABC) transporter
LEO74_09900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO74_09905	COG3162	membrane
LEO74_09920	COG1024	Enoyl-CoA hydratase
LEO74_09965	COG1115	amino acid carrier protein
LEO74_09980	COG1584	GPR1 FUN34 yaaH family protein
LEO74_10015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEO74_10020	COG1960	acyl-CoA dehydrogenase activity
LEO74_10030	COG1960	acyl-CoA dehydrogenase activity
LEO74_10035	COG1024	Enoyl-CoA hydratase
LEO74_10040	COG1024	Enoyl-CoA hydratase
LEO74_10050	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_10060	COG0730	response to heat
LEO74_10070	COG0582	viral genome integration into host DNA
LEO74_10085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEO74_10115	COG2003	Belongs to the UPF0758 family
LEO74_10130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LEO74_10160	COG3300	MHYT domain
LEO74_10160	COG5001	Diguanylate cyclase
LEO74_10165	COG0583	DNA-binding transcription factor activity
LEO74_10170	COG2723	6-phospho-beta-galactosidase activity
LEO74_10175	COG3300	MHYT domain
LEO74_10175	COG5001	Diguanylate cyclase
LEO74_10185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO74_10195	COG0583	DNA-binding transcription factor activity
LEO74_10215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LEO74_10220	COG0673	inositol 2-dehydrogenase activity
LEO74_10225	COG0583	DNA-binding transcription factor activity
LEO74_10235	COG1560	Kdo2-lipid A biosynthetic process
LEO74_10240	COG1560	Kdo2-lipid A biosynthetic process
LEO74_10265	COG0417	DNA replication proofreading
LEO74_10295	COG0534	Mate efflux family protein
LEO74_10305	COG0307	riboflavin synthase, alpha
LEO74_10315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO74_10320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEO74_10325	COG0697	spore germination
LEO74_10330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO74_10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO74_10375	COG3099	Belongs to the UPF0263 family
LEO74_10380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEO74_10385	COG2894	cell division
LEO74_10390	COG0850	regulation of cytokinetic process
LEO74_10395	COG3100	YcgL domain-containing protein
LEO74_10400	COG2951	lytic endotransglycosylase activity
LEO74_10405	COG1760	l-serine dehydratase
LEO74_10410	COG1760	l-serine dehydratase
LEO74_10415	COG3123	guanosine phosphorylase activity
LEO74_10435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LEO74_10440	COG2067	long-chain fatty acid transport protein
LEO74_10455	COG1595	DNA-templated transcription, initiation
LEO74_10485	COG0714	Associated with various cellular activities
LEO74_10490	COG0183	Belongs to the thiolase family
LEO74_10495	COG1024	Enoyl-CoA hydratase
LEO74_10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO74_10515	COG3829	transcription factor binding
LEO74_10520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO74_10525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEO74_10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO74_10540	COG0549	Belongs to the carbamate kinase family
LEO74_10545	COG0697	spore germination
LEO74_10550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LEO74_10550	COG3608	succinylglutamate desuccinylase aspartoacylase
LEO74_10555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEO74_10560	COG2068	MobA-Related Protein
LEO74_10565	COG0493	'glutamate synthase
LEO74_10565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_10570	COG0402	S-adenosylhomocysteine deaminase activity
LEO74_10575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO74_10580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO74_10580	COG2080	2 iron, 2 sulfur cluster binding
LEO74_10585	COG2233	PERMEase
LEO74_10590	COG0402	S-adenosylhomocysteine deaminase activity
LEO74_10595	COG2252	PERMEase
LEO74_10600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO74_10605	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO74_10610	COG2080	2 iron, 2 sulfur cluster binding
LEO74_10620	COG3134	Outer membrane lipoprotein
LEO74_10630	COG1288	antiporter activity
LEO74_10635	COG0318	PFAM AMP-dependent synthetase and ligase
LEO74_10640	COG0140	phosphoribosyl-ATP diphosphatase activity
LEO74_10640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEO74_10645	COG0107	imidazoleglycerol-phosphate synthase activity
LEO74_10650	COG2198	Histidine kinase
LEO74_10650	COG0784	Response regulator, receiver
LEO74_10650	COG2205	protein histidine kinase activity
LEO74_10655	COG2199	diguanylate cyclase activity
LEO74_10660	COG3437	response regulator, receiver
LEO74_10665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEO74_10670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO74_10675	COG0131	Imidazoleglycerol-phosphate dehydratase
LEO74_10675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO74_10680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEO74_10685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEO74_10690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEO74_10700	COG1199	ATP-dependent helicase activity
LEO74_10705	COG1214	PFAM Peptidase M22, glycoprotease
LEO74_10715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LEO74_10715	COG2226	methyltransferase
LEO74_10715	COG0596	Alpha beta hydrolase
LEO74_10720	COG0318	PFAM AMP-dependent synthetase and ligase
LEO74_10725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LEO74_10740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO74_10745	COG2832	Protein of unknown function (DUF454)
LEO74_10750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEO74_10760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEO74_10780	COG0617	tRNA 3'-terminal CCA addition
LEO74_10780	COG0517	IMP dehydrogenase activity
LEO74_10780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO74_10785	COG1643	Atp-dependent helicase
LEO74_10795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEO74_10805	COG3437	response regulator, receiver
LEO74_10810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO74_10815	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LEO74_10820	COG0709	Synthesizes selenophosphate from selenide and ATP
LEO74_10835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO74_10845	COG1254	Belongs to the acylphosphatase family
LEO74_10850	COG0625	glutathione transferase activity
LEO74_10855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO74_10855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO74_10860	COG0489	protein tyrosine kinase activity
LEO74_10865	COG0572	uridine kinase
LEO74_10870	COG0717	Belongs to the dCTP deaminase family
LEO74_10875	COG0306	phosphate transporter
LEO74_10880	COG1530	ribonuclease E activity
LEO74_10885	COG0564	pseudouridine synthase activity
LEO74_10890	COG0546	phosphoglycolate phosphatase activity
LEO74_10895	COG0424	maF-like protein
LEO74_10900	COG2814	Major facilitator Superfamily
LEO74_10915	COG1399	metal-binding, possibly nucleic acid-binding protein
LEO74_10920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEO74_10925	COG0416	fatty acid biosynthetic process
LEO74_10930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO74_10940	COG1028	Short-chain dehydrogenase reductase Sdr
LEO74_10945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO74_10955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEO74_10960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEO74_10965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEO74_10970	COG0470	DNA polymerase III
LEO74_10975	COG0084	hydrolase, TatD family'
LEO74_10990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO74_10990	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEO74_10995	COG3008	intermembrane lipid transfer
LEO74_11000	COG2995	paraquat-inducible protein a
LEO74_11010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LEO74_11015	COG0372	Belongs to the citrate synthase family
LEO74_11060	COG4221	oxidoreductase activity
LEO74_11070	COG3141	response to X-ray
LEO74_11130	COG1067	ATP-dependent peptidase activity
LEO74_11135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO74_11150	COG0488	(ABC) transporter
LEO74_11160	COG0116	Belongs to the methyltransferase superfamily
LEO74_11160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO74_11170	COG0167	dihydroorotate dehydrogenase activity
LEO74_11175	COG2902	Dehydrogenase
LEO74_11185	COG0308	aminopeptidase N
LEO74_11195	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LEO74_11200	COG1956	GAF domain-containing protein
LEO74_11210	COG3278	Belongs to the heme-copper respiratory oxidase family
LEO74_11225	COG2010	Cytochrome c
LEO74_11250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO74_11255	COG0589	response to stress
LEO74_11260	COG0037	tRNA processing
LEO74_11275	COG0625	glutathione transferase activity
LEO74_11280	COG1869	D-ribose catabolic process
LEO74_11285	COG1129	ABC transporter
LEO74_11290	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO74_11295	COG1879	ABC-type sugar transport system periplasmic component
LEO74_11300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO74_11305	COG1609	Transcriptional regulator
LEO74_11310	COG5001	Diguanylate cyclase
LEO74_11310	COG3300	MHYT domain
LEO74_11340	COG0776	regulation of translation
LEO74_11345	COG0072	phenylalanine-tRNA ligase activity
LEO74_11345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO74_11350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEO74_11355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEO74_11360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEO74_11365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEO74_11370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEO74_11395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO74_11405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO74_11410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO74_11415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO74_11420	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEO74_11425	COG3313	Fe-S protein
LEO74_11430	COG2942	2-epimerase
LEO74_11435	COG3716	PTS system mannose fructose sorbose family IID component
LEO74_11440	COG3715	PTS system
LEO74_11445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_11445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_11460	COG1609	Transcriptional regulator
LEO74_11465	COG2140	Oxalate decarboxylase
LEO74_11470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_11470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_11470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LEO74_11475	COG1105	Belongs to the carbohydrate kinase PfkB family
LEO74_11480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_11480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_11485	COG1609	Transcriptional regulator
LEO74_11490	COG0814	amino acid
LEO74_11500	COG5654	RES domain protein
LEO74_11505	COG0513	Belongs to the DEAD box helicase family
LEO74_11515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEO74_11520	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO74_11525	COG2840	Smr protein MutS2
LEO74_11535	COG3706	GGDEF domain
LEO74_11540	COG0406	alpha-ribazole phosphatase activity
LEO74_11565	COG2824	Alkylphosphonate utilization operon protein PhnA
LEO74_11575	COG0384	phenazine biosynthesis protein PhzF
LEO74_11605	COG0242	peptide deformylase activity
LEO74_11625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO74_11630	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LEO74_11640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO74_11645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LEO74_11655	COG0205	6-phosphofructokinase activity
LEO74_11660	COG1473	amidohydrolase
LEO74_11665	COG1011	Hydrolase
LEO74_11670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO74_11720	COG3593	DNA synthesis involved in DNA repair
LEO74_11735	COG0583	DNA-binding transcription factor activity
LEO74_11740	COG0730	response to heat
LEO74_11745	COG3148	PFAM DTW domain containing protein
LEO74_11755	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEO74_11765	COG0386	Belongs to the glutathione peroxidase family
LEO74_11770	COG0513	Belongs to the DEAD box helicase family
LEO74_11775	COG0456	acetyltransferase
LEO74_11785	COG1742	UPF0060 membrane protein
LEO74_11815	COG2329	Antibiotic biosynthesis monooxygenase
LEO74_11820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO74_11840	COG3243	poly(R)-hydroxyalkanoic acid synthase
LEO74_11850	COG2501	S4 domain
LEO74_11865	COG1132	(ABC) transporter
LEO74_11870	COG1132	(ABC) transporter
LEO74_11880	COG3118	belongs to the thioredoxin family
LEO74_11885	COG0471	metal ion transport
LEO74_11890	COG0058	SHG alpha-glucan phosphorylase activity
LEO74_11920	COG0814	amino acid
LEO74_11925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LEO74_11930	COG0514	ATP-dependent DNA helicase (RecQ)
LEO74_11935	COG2766	serine protein kinase
LEO74_11945	COG2719	SpoVR family
LEO74_11950	COG2186	Transcriptional regulator
LEO74_11955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO74_11960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO74_11965	COG0586	Pfam SNARE associated Golgi protein
LEO74_11975	COG0556	nucleotide-excision repair
LEO74_11985	COG0569	domain protein
LEO74_11985	COG2985	domain, Protein
LEO74_12010	COG4565	transcriptional regulatory protein
LEO74_12015	COG3290	protein histidine kinase activity
LEO74_12020	COG1846	Transcriptional regulator
LEO74_12020	COG1940	carbohydrate kinase activity
LEO74_12025	COG0840	transmembrane signaling receptor activity
LEO74_12030	COG3012	SEC-C Motif Domain Protein
LEO74_12035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEO74_12040	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEO74_12045	COG0247	lactate metabolic process
LEO74_12065	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO74_12070	COG0437	4 iron, 4 sulfur cluster binding
LEO74_12075	COG3301	Polysulphide reductase, NrfD
LEO74_12080	COG1138	Cytochrome C-type biogenesis protein
LEO74_12085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO74_12090	COG3088	subunit of a heme lyase
LEO74_12090	COG4235	cytochrome complex assembly
LEO74_12095	COG1051	belongs to the nudix hydrolase family
LEO74_12105	COG3033	Beta-eliminating lyase
LEO74_12115	COG3046	protein related to deoxyribodipyrimidine photolyase
LEO74_12120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO74_12145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEO74_12160	COG4774	siderophore transport
LEO74_12165	COG4977	sequence-specific DNA binding
LEO74_12175	COG0583	DNA-binding transcription factor activity
LEO74_12180	COG2910	NAD(P)H-binding
LEO74_12195	COG0612	Peptidase, M16
LEO74_12200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO74_12210	COG1944	ATP diphosphatase activity
LEO74_12215	COG2116	formate transmembrane transporter activity
LEO74_12220	COG1882	Formate acetyltransferase
LEO74_12225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO74_12230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LEO74_12235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LEO74_12245	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO74_12250	COG3842	ATPase activity
LEO74_12260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO74_12265	COG2983	Belongs to the UPF0260 family
LEO74_12275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LEO74_12280	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO74_12285	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO74_12290	COG0567	Dehydrogenase, E1 component
LEO74_12300	COG1053	succinate dehydrogenase
LEO74_12305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LEO74_12330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO74_12335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO74_12335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LEO74_12345	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO74_12360	COG1451	nucleotide metabolic process
LEO74_12375	COG0254	rRNA binding
LEO74_12380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO74_12390	COG0583	DNA-binding transcription factor activity
LEO74_12410	COG1879	ABC-type sugar transport system periplasmic component
LEO74_12415	COG1069	ribulokinase activity
LEO74_12425	COG2160	L-arabinose isomerase activity
LEO74_12430	COG2925	Exonuclease
LEO74_12440	COG3345	alpha-galactosidase
LEO74_12445	COG1380	Effector of murein hydrolase LrgA
LEO74_12450	COG1346	cytolysis
LEO74_12455	COG0295	cytidine deaminase activity
LEO74_12460	COG1022	Amp-dependent synthetase and ligase
LEO74_12475	COG0861	Integral membrane protein TerC family
LEO74_12480	COG2885	chlorophyll binding
LEO74_12485	COG2199	diguanylate cyclase activity
LEO74_12515	COG3768	UPF0283 membrane protein
LEO74_12520	COG3106	COG3106 Predicted ATPase
LEO74_12535	COG1842	Phage shock protein A
LEO74_12540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LEO74_12550	COG4168	peptide transport system, permease
LEO74_12555	COG4171	peptide transport system, permease
LEO74_12565	COG4172	Belongs to the ABC transporter superfamily
LEO74_12575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEO74_12580	COG1286	toxin biosynthetic process
LEO74_12585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEO74_12590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEO74_12595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LEO74_12600	COG0531	amino acid
LEO74_12600	COG1674	ftsk spoiiie
LEO74_12610	COG0686	Belongs to the AlaDH PNT family
LEO74_12615	COG0492	ferredoxin-NADP+ reductase activity
LEO74_12620	COG3706	GGDEF domain
LEO74_12625	COG3134	Outer membrane lipoprotein
LEO74_12630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEO74_12635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LEO74_12640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEO74_12645	COG0542	response to heat
LEO74_12650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEO74_12655	COG1278	Cold shock
LEO74_12660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEO74_12720	COG3829	transcription factor binding
LEO74_12795	COG3501	Rhs element vgr protein
LEO74_12825	COG1435	thymidine kinase activity
LEO74_12830	COG1757	Na H antiporter
LEO74_12835	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO74_12840	COG2096	Adenosyltransferase
LEO74_12845	COG3530	Putative quorum-sensing-regulated virulence factor
LEO74_12850	COG0602	queuosine metabolic process
LEO74_12855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEO74_12875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LEO74_12885	COG0776	regulation of translation
LEO74_12890	COG0539	negative regulation of cytoplasmic translation
LEO74_12895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEO74_12900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO74_12910	COG0583	DNA-binding transcription factor activity
LEO74_12930	COG0778	Nitroreductase
LEO74_12935	COG3300	MHYT domain
LEO74_12935	COG5001	Diguanylate cyclase
LEO74_12945	COG0583	DNA-binding transcription factor activity
LEO74_12950	COG3437	response regulator, receiver
LEO74_12975	COG4989	oxidoreductase activity
LEO74_12980	COG0724	RNA recognition motif
LEO74_13000	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEO74_13015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO74_13020	COG1360	Flagellar Motor Protein
LEO74_13025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_13030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_13035	COG0649	NAD binding
LEO74_13035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_13050	COG1034	ATP synthesis coupled electron transport
LEO74_13055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LEO74_13060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_13065	COG0839	Belongs to the complex I subunit 6 family
LEO74_13070	COG0713	ATP synthesis coupled electron transport
LEO74_13080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO74_13085	COG1007	ATP synthesis coupled electron transport
LEO74_13090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEO74_13090	COG0047	phosphoribosylformylglycinamidine synthase activity
LEO74_13095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO74_13100	COG1645	bacterial-type flagellum-dependent swarming motility
LEO74_13105	COG1160	GTP binding
LEO74_13110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO74_13115	COG2976	Protein conserved in bacteria
LEO74_13120	COG0124	histidyl-tRNA synthetase
LEO74_13125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LEO74_13140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEO74_13145	COG0105	UTP biosynthetic process
LEO74_13150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO74_13160	COG0633	Ferredoxin
LEO74_13165	COG0443	Heat shock 70 kDa protein
LEO74_13170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO74_13180	COG0822	iron-sulfur transferase activity
LEO74_13185	COG1104	cysteine desulfurase activity
LEO74_13205	COG3154	lipid carrier protein
LEO74_13210	COG0826	peptidase U32
LEO74_13215	COG0826	peptidase U32
LEO74_13230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO74_13235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO74_13240	COG1862	Preprotein translocase
LEO74_13245	COG0343	queuine tRNA-ribosyltransferase activity
LEO74_13250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEO74_13255	COG0517	IMP dehydrogenase activity
LEO74_13265	COG3634	alkyl hydroperoxide reductase activity
LEO74_13285	COG1393	Belongs to the ArsC family
LEO74_13290	COG0798	PFAM Bile acid sodium symporter
LEO74_13320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO74_13320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO74_13325	COG0509	glycine decarboxylation via glycine cleavage system
LEO74_13330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEO74_13335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO74_13340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO74_13360	COG2814	Major facilitator Superfamily
LEO74_13365	COG0625	glutathione transferase activity
LEO74_13375	COG0483	inositol monophosphate 1-phosphatase activity
LEO74_13395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO74_13415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO74_13425	COG2089	acid synthase
LEO74_13430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LEO74_13450	COG1083	cytidylyl-transferase
LEO74_13480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO74_13500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO74_13500	COG0301	tRNA thio-modification
LEO74_13510	COG4953	penicillin-binding protein 1C
LEO74_13515	COG2373	Large extracellular alpha-helical protein
LEO74_13520	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO74_13530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO74_13550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_13560	COG2431	L-lysine efflux transmembrane transporter activity
LEO74_13565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO74_13570	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LEO74_13585	COG1393	Belongs to the ArsC family
LEO74_13595	COG4783	chaperone-mediated protein folding
LEO74_13600	COG0425	Belongs to the sulfur carrier protein TusA family
LEO74_13625	COG3842	ATPase activity
LEO74_13630	COG3833	ABC-type maltose transport systems, permease component
LEO74_13635	COG1175	transmembrane transport
LEO74_13645	COG3081	Nucleoid-associated protein
LEO74_13650	COG3082	Protein of unknown function (DUF1414)
LEO74_13655	COG3083	sulfuric ester hydrolase activity
LEO74_13660	COG4771	TonB-dependent receptor
LEO74_13665	COG1770	oligopeptidase
LEO74_13685	COG4574	serine-type endopeptidase inhibitor activity
LEO74_13690	COG3085	chromosome segregation
LEO74_13695	COG0583	DNA-binding transcription factor activity
LEO74_13700	COG0287	Prephenate dehydrogenase
LEO74_13700	COG1605	Chorismate mutase
LEO74_13705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO74_13710	COG0584	glycerophosphoryl diester phosphodiesterase
LEO74_13725	COG1349	DNA-binding transcription factor activity
LEO74_13730	COG2271	Major facilitator Superfamily
LEO74_13735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO74_13740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEO74_13745	COG0583	DNA-binding transcription factor activity
LEO74_13770	COG0656	L-ascorbic acid biosynthetic process
LEO74_13775	COG2814	Major facilitator Superfamily
LEO74_13785	COG1294	oxidase, subunit
LEO74_13790	COG1271	oxidase subunit
LEO74_13795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO74_13805	COG2979	Protein of unknown function (DUF533)
LEO74_13830	COG2271	Major facilitator Superfamily
LEO74_13835	COG0583	DNA-binding transcription factor activity
LEO74_13845	COG2807	transmembrane transport
LEO74_13850	COG1187	pseudouridine synthase activity
LEO74_13875	COG1403	HNH endonuclease
LEO74_13890	COG3681	Belongs to the UPF0597 family
LEO74_13900	COG0814	amino acid
LEO74_13920	COG1166	arginine decarboxylase activity
LEO74_13930	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO74_13960	COG0583	DNA-binding transcription factor activity
LEO74_13970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEO74_13975	COG0840	transmembrane signaling receptor activity
LEO74_13980	COG0302	gtp cyclohydrolase
LEO74_13990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO74_13995	COG2267	carboxylic ester hydrolase activity
LEO74_14000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LEO74_14015	COG0314	molybdopterin synthase activity
LEO74_14020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEO74_14025	COG0315	cyclic pyranopterin monophosphate synthase activity
LEO74_14030	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO74_14035	COG3005	denitrification pathway
LEO74_14045	COG0348	domain, Protein
LEO74_14050	COG0437	4 iron, 4 sulfur cluster binding
LEO74_14055	COG0243	molybdopterin cofactor binding
LEO74_14065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_14065	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_14070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO74_14075	COG3850	Histidine kinase
LEO74_14080	COG2197	response regulator
LEO74_14110	COG0121	glutamine amidotransferase
LEO74_14115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO74_14120	COG1960	acyl-CoA dehydrogenase activity
LEO74_14125	COG0784	Response regulator, receiver
LEO74_14125	COG3437	response regulator, receiver
LEO74_14140	COG0328	RNA-DNA hybrid ribonuclease activity
LEO74_14145	COG2226	methyltransferase
LEO74_14150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO74_14160	COG0741	lytic transglycosylase activity
LEO74_14160	COG1388	LysM domain
LEO74_14165	COG3021	interspecies interaction between organisms
LEO74_14175	COG1607	acyl-coa hydrolase
LEO74_14190	COG0741	lytic transglycosylase activity
LEO74_14200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEO74_14220	COG2911	Protein conserved in bacteria
LEO74_14225	COG0729	surface antigen
LEO74_14235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO74_14240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO74_14250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO74_14260	COG4134	Bacterial extracellular solute-binding protein
LEO74_14270	COG4136	ATPase activity
LEO74_14275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEO74_14280	COG2951	lytic endotransglycosylase activity
LEO74_14295	COG1846	Transcriptional regulator
LEO74_14305	COG0033	Phosphoglucomutase
LEO74_14310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LEO74_14315	COG0596	Alpha beta hydrolase
LEO74_14330	COG0716	FMN binding
LEO74_14340	COG0735	belongs to the Fur family
LEO74_14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO74_14360	COG2190	(PTS) system
LEO74_14360	COG1263	PTS System
LEO74_14360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_14365	COG0363	glucosamine-6-phosphate deaminase activity
LEO74_14370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO74_14375	COG1940	carbohydrate kinase activity
LEO74_14375	COG1846	Transcriptional regulator
LEO74_14380	COG2194	sulfuric ester hydrolase activity
LEO74_14385	COG0217	transcriptional regulatory protein
LEO74_14390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEO74_14395	COG1801	Protein of unknown function DUF72
LEO74_14400	COG4106	trans-aconitate 2-methyltransferase activity
LEO74_14405	COG0500	methyltransferase
LEO74_14425	COG0450	alkyl hydroperoxide reductase
LEO74_14430	COG0583	DNA-binding transcription factor activity
LEO74_14445	COG0791	NLP P60 protein
LEO74_14460	COG1309	transcriptional regulator
LEO74_14500	COG0534	Mate efflux family protein
LEO74_14520	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO74_14520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LEO74_14520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO74_14520	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO74_14530	COG0633	Ferredoxin
LEO74_14530	COG3217	Mosc domain protein beta barrel domain protein
LEO74_14530	COG0633	Ferredoxin
LEO74_14530	COG3217	Mosc domain protein beta barrel domain protein
LEO74_14540	COG0501	Belongs to the peptidase M48B family
LEO74_14545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEO74_14550	COG1073	alpha beta
LEO74_14550	COG2226	methyltransferase
LEO74_14555	COG0156	8-amino-7-oxononanoate synthase activity
LEO74_14560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO74_14580	COG0017	Asparaginyl-tRNA synthetase
LEO74_14585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO74_14600	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO74_14610	COG0583	DNA-binding transcription factor activity
LEO74_14615	COG1393	Belongs to the ArsC family
LEO74_14620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO74_14625	COG1876	peptidase activity
LEO74_14635	COG3263	regulation of cellular component size
LEO74_14655	COG1280	lysine exporter protein (LysE YggA)
LEO74_14685	COG0564	pseudouridine synthase activity
LEO74_14695	COG1454	alcohol dehydrogenase
LEO74_14700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO74_14705	COG0702	epimerase
LEO74_14710	COG2914	Belongs to the UPF0125 (RnfH) family
LEO74_14715	COG2867	negative regulation of translational initiation
LEO74_14720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEO74_14740	COG0514	ATP-dependent DNA helicase (RecQ)
LEO74_14745	COG1940	carbohydrate kinase activity
LEO74_14750	COG0583	DNA-binding transcription factor activity
LEO74_14755	COG3048	D-serine ammonia-lyase activity
LEO74_14765	COG0538	isocitrate dehydrogenase activity
LEO74_14770	COG2207	Transcriptional regulator
LEO74_14775	COG1482	cell wall glycoprotein biosynthetic process
LEO74_14790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_14800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO74_14805	COG1263	PTS System
LEO74_14805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_14810	COG1609	Transcriptional regulator
LEO74_14820	COG0789	Transcriptional regulator
LEO74_14850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_14850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_14850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_14860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO74_14870	COG1187	pseudouridine synthase activity
LEO74_14880	COG0482	sulfurtransferase activity
LEO74_14885	COG2915	High frequency lysogenization protein hflD homolog
LEO74_14890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEO74_14895	COG2850	peptidyl-arginine hydroxylation
LEO74_14905	COG3153	acetyltransferase
LEO74_14915	COG0625	glutathione transferase activity
LEO74_14920	COG0259	pyridoxamine-phosphate oxidase activity
LEO74_14935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO74_14935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO74_14940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEO74_14955	COG4235	cytochrome complex assembly
LEO74_14955	COG3088	subunit of a heme lyase
LEO74_14960	COG4235	cytochrome complex assembly
LEO74_14960	COG3088	subunit of a heme lyase
LEO74_14965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO74_14970	COG1138	Cytochrome C-type biogenesis protein
LEO74_14975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEO74_14980	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO74_14985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO74_14990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO74_15005	COG0835	chemotaxis
LEO74_15015	COG1192	Involved in chromosome partitioning
LEO74_15020	COG1360	Flagellar Motor Protein
LEO74_15025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO74_15030	COG2201	protein-glutamate methylesterase activity
LEO74_15035	COG0784	Response regulator, receiver
LEO74_15035	COG2198	Histidine kinase
LEO74_15035	COG0643	Histidine kinase
LEO74_15040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LEO74_15065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEO74_15075	COG1684	flagellar biosynthetic protein fliR
LEO74_15130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEO74_15140	COG1677	Flagellar hook-basal body complex protein FliE
LEO74_15155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO74_15165	COG1073	alpha beta
LEO74_15165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LEO74_15165	COG3064	Membrane
LEO74_15170	COG2994	toxin metabolic process
LEO74_15180	COG2274	protein secretion by the type I secretion system
LEO74_15190	COG2274	protein secretion by the type I secretion system
LEO74_15210	COG1737	Transcriptional regulator
LEO74_15215	COG0469	pyruvate kinase activity
LEO74_15225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_15230	COG1960	acyl-CoA dehydrogenase activity
LEO74_15240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEO74_15250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO74_15270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO74_15280	COG1401	restriction endodeoxyribonuclease activity
LEO74_15285	COG0732	type I restriction modification DNA specificity domain
LEO74_15290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEO74_15340	COG2003	Belongs to the UPF0758 family
LEO74_15385	COG5377	YqaJ viral recombinase family
LEO74_15405	COG4983	Phage plasmid primase, P4 family domain protein
LEO74_15455	COG0789	Transcriptional regulator
LEO74_15460	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO74_15485	COG0243	molybdopterin cofactor binding
LEO74_15490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO74_15495	COG0583	DNA-binding transcription factor activity
LEO74_15535	COG1454	alcohol dehydrogenase
LEO74_15535	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_15545	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_15545	COG1454	alcohol dehydrogenase
LEO74_15550	COG1882	Formate acetyltransferase
LEO74_15555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO74_15565	COG4869	propanediol catabolic process
LEO74_15585	COG5002	protein histidine kinase activity
LEO74_15590	COG0745	RESPONSE REGULATOR receiver
LEO74_15595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_15600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_15610	COG1388	LysM domain
LEO74_15610	COG1376	ErfK ybiS ycfS ynhG family protein
LEO74_15625	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LEO74_15630	COG0791	NLP P60 protein
LEO74_15635	COG2091	lysine biosynthetic process via aminoadipic acid
LEO74_15640	COG3118	belongs to the thioredoxin family
LEO74_15650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO74_15655	COG0788	formyltetrahydrofolate deformylase activity
LEO74_15665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO74_15685	COG0366	Alpha amylase catalytic
LEO74_15690	COG0741	lytic transglycosylase activity
LEO74_15690	COG0739	heme binding
LEO74_15690	COG1196	nuclear chromosome segregation
LEO74_15695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO74_15700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEO74_15705	COG0673	inositol 2-dehydrogenase activity
LEO74_15725	COG3152	Membrane
LEO74_15745	COG1032	radical SAM domain protein
LEO74_15755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO74_15760	COG1566	PFAM secretion protein HlyD family protein
LEO74_15770	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO74_15775	COG0733	neurotransmitter:sodium symporter activity
LEO74_15805	COG0281	malic enzyme
LEO74_15815	COG0534	Mate efflux family protein
LEO74_15830	COG2233	PERMEase
LEO74_15835	COG0095	Lipoate-protein ligase
LEO74_15840	COG1115	amino acid carrier protein
LEO74_15845	COG0019	diaminopimelate decarboxylase activity
LEO74_15855	COG0678	peroxiredoxin activity
LEO74_15865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LEO74_15885	COG1131	(ABC) transporter
LEO74_15890	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO74_15900	COG3142	Participates in the control of copper homeostasis
LEO74_15925	COG5002	protein histidine kinase activity
LEO74_15930	COG0745	RESPONSE REGULATOR receiver
LEO74_15935	COG0346	lactoylglutathione lyase activity
LEO74_15940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LEO74_15945	COG1960	acyl-CoA dehydrogenase activity
LEO74_15950	COG3284	Transcriptional regulator
LEO74_15965	COG0697	spore germination
LEO74_15970	COG4565	transcriptional regulatory protein
LEO74_15975	COG3290	protein histidine kinase activity
LEO74_15980	COG0281	malic enzyme
LEO74_15995	COG1846	Transcriptional regulator
LEO74_16000	COG1566	PFAM secretion protein HlyD family protein
LEO74_16030	COG0602	queuosine metabolic process
LEO74_16035	COG1328	CTP reductase activity
LEO74_16045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEO74_16050	COG3115	cell septum assembly
LEO74_16055	COG1196	nuclear chromosome segregation
LEO74_16065	COG2860	membrane
LEO74_16075	COG3108	Peptidase M15
LEO74_16080	COG2989	Protein conserved in bacteria
LEO74_16095	COG0463	Glycosyl transferase, family 2
LEO74_16110	COG0366	Alpha amylase catalytic
LEO74_16145	COG3706	GGDEF domain
LEO74_16150	COG0037	tRNA processing
LEO74_16155	COG3590	peptidase
LEO74_16165	COG0488	(ABC) transporter
LEO74_16175	COG0531	amino acid
LEO74_16185	COG1073	alpha beta
LEO74_16190	COG1073	alpha beta
LEO74_16200	COG1234	tRNA 3'-trailer cleavage
LEO74_16205	COG0814	amino acid
LEO74_16220	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO74_16225	COG1982	Orn Lys Arg decarboxylase major
LEO74_16230	COG0531	amino acid
LEO74_16235	COG3710	Transcriptional regulator
LEO74_16240	COG0825	malonyl-CoA metabolic process
LEO74_16250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEO74_16255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO74_16260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO74_16265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO74_16270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO74_16285	COG0750	zinc metalloprotease
LEO74_16290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEO74_16295	COG0575	Belongs to the CDS family
LEO74_16300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEO74_16305	COG0233	cytoplasmic translational termination
LEO74_16310	COG0528	UMP kinase activity
LEO74_16315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEO74_16320	COG0052	Belongs to the universal ribosomal protein uS2 family
LEO74_16325	COG0024	Methionine aminopeptidase
LEO74_16330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEO74_16335	COG2171	N-acyltransferase activity
LEO74_16345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_16345	COG1263	PTS System
LEO74_16355	COG4580	involved in the transport of maltose and maltodextrins
LEO74_16365	COG0564	pseudouridine synthase activity
LEO74_16370	COG3098	single-species biofilm formation
LEO74_16395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LEO74_16405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO74_16405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO74_16420	COG1611	Belongs to the LOG family
LEO74_16425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO74_16430	COG0473	3-isopropylmalate dehydrogenase activity
LEO74_16440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEO74_16445	COG2363	Small membrane protein
LEO74_16455	COG0583	DNA-binding transcription factor activity
LEO74_16460	COG0840	transmembrane signaling receptor activity
LEO74_16465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO74_16480	COG1477	protein flavinylation
LEO74_16485	COG2871	sodium ion transport
LEO74_16490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO74_16495	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO74_16500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO74_16505	COG1805	sodium ion transport
LEO74_16510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO74_16515	COG0271	Belongs to the BolA IbaG family
LEO74_16520	COG2813	Specifically methylates the guanine in position
LEO74_16530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO74_16540	COG2211	Major facilitator Superfamily
LEO74_16545	COG3248	Nucleoside-binding outer membrane protein
LEO74_16550	COG1666	GTP binding
LEO74_16555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEO74_16560	COG0693	protein deglycase activity
LEO74_16605	COG3501	Rhs element vgr protein
LEO74_16620	COG2771	luxR family
LEO74_16630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO74_16630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO74_16635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO74_16645	COG1151	hydroxylamine reductase activity
LEO74_16650	COG0783	Belongs to the Dps family
LEO74_16675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEO74_16690	COG4221	oxidoreductase activity
LEO74_16700	COG0415	Belongs to the DNA photolyase family
LEO74_16705	COG0789	Transcriptional regulator
LEO74_16710	COG3272	Protein of unknown function (DUF1722)
LEO74_16740	COG0077	Prephenate dehydratase
LEO74_16740	COG1605	Chorismate mutase
LEO74_16775	COG0840	transmembrane signaling receptor activity
LEO74_16785	COG0300	oxidoreductase activity
LEO74_16810	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEO74_16835	COG0826	peptidase U32
LEO74_16840	COG1280	lysine exporter protein (LysE YggA)
LEO74_16850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO74_16855	COG0840	transmembrane signaling receptor activity
LEO74_16870	COG0643	Histidine kinase
LEO74_16870	COG2198	Histidine kinase
LEO74_16880	COG0835	chemotaxis
LEO74_16885	COG0840	transmembrane signaling receptor activity
LEO74_16895	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LEO74_16900	COG2201	protein-glutamate methylesterase activity
LEO74_16905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO74_16935	COG2197	response regulator
LEO74_16945	COG3188	usher protein
LEO74_16960	COG2203	Gaf domain
LEO74_16960	COG2199	diguanylate cyclase activity
LEO74_16960	COG2200	EAL domain
LEO74_16965	COG0826	peptidase U32
LEO74_16970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO74_16980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO74_16995	COG2200	EAL domain
LEO74_17000	COG0737	Belongs to the 5'-nucleotidase family
LEO74_17020	COG2204	response regulator
LEO74_17025	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO74_17040	COG1047	Peptidyl-prolyl cis-trans
LEO74_17045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LEO74_17055	COG0784	Response regulator, receiver
LEO74_17055	COG0835	chemotaxis
LEO74_17060	COG0429	hydrolase of the alpha beta-hydrolase fold
LEO74_17065	COG4251	negative regulation of phosphorylation
LEO74_17065	COG2203	Gaf domain
LEO74_17065	COG5001	Diguanylate cyclase
LEO74_17065	COG3706	GGDEF domain
LEO74_17070	COG3089	Belongs to the UPF0270 family
LEO74_17080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO74_17085	COG0463	Glycosyl transferase, family 2
LEO74_17090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO74_17090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO74_17095	COG0726	polysaccharide deacetylase
LEO74_17100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEO74_17105	COG2076	Multidrug Resistance protein
LEO74_17110	COG2076	Multidrug Resistance protein
LEO74_17115	COG3954	Phosphoribulokinase
LEO74_17130	COG1765	OsmC-like protein
LEO74_17140	COG2226	methyltransferase
LEO74_17145	COG3397	chitin binding
LEO74_17160	COG2202	Pas domain
LEO74_17160	COG2205	protein histidine kinase activity
LEO74_17170	COG3655	Transcriptional regulator
LEO74_17175	COG2814	Major facilitator Superfamily
LEO74_17180	COG4771	TonB-dependent receptor
LEO74_17200	COG0748	coenzyme F420 binding
LEO74_17205	COG3721	Heme iron utilization protein
LEO74_17215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO74_17240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO74_17245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO74_17250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LEO74_17270	COG0741	lytic transglycosylase activity
LEO74_17275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO74_17290	COG0488	(ABC) transporter
LEO74_17300	COG2252	PERMEase
LEO74_17305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO74_17310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEO74_17315	COG3178	'Phosphotransferase
LEO74_17320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO74_17330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEO74_17335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEO74_17340	COG2967	ApaG domain
LEO74_17345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO74_17355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEO74_17360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO74_17375	COG0318	PFAM AMP-dependent synthetase and ligase
LEO74_17380	COG3314	Sporulation integral membrane protein YlbJ
LEO74_17385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEO74_17390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEO74_17395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEO74_17400	COG0142	geranyltranstransferase activity
LEO74_17405	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LEO74_17410	COG0330	HflC and HflK could
LEO74_17415	COG0330	HflC and HflK could
LEO74_17420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEO74_17425	COG1923	regulation of RNA biosynthetic process
LEO74_17430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEO74_17435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO74_17445	COG0802	atpase or kinase
LEO74_17450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEO74_17450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEO74_17455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LEO74_17470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEO74_17475	COG2011	ABC-type metal ion transport system permease component
LEO74_17480	COG1464	Belongs to the NlpA lipoprotein family
LEO74_17490	COG0840	transmembrane signaling receptor activity
LEO74_17515	COG0784	Response regulator, receiver
LEO74_17515	COG2198	Histidine kinase
LEO74_17515	COG5002	protein histidine kinase activity
LEO74_17535	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LEO74_17550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEO74_17555	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LEO74_17565	COG2716	regulation of RNA biosynthetic process
LEO74_17570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEO74_17575	COG3013	Belongs to the UPF0304 family
LEO74_17585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO74_17590	COG0280	phosphate acetyltransferase
LEO74_17590	COG0857	belongs to the CobB CobQ family
LEO74_17600	COG0028	Belongs to the TPP enzyme family
LEO74_17610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO74_17615	COG0671	phosphoesterase, PA-phosphatase related
LEO74_17625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO74_17630	COG0473	3-isopropylmalate dehydrogenase activity
LEO74_17635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEO74_17640	COG0066	3-isopropylmalate dehydratase activity
LEO74_17655	COG4143	(ABC) transporter
LEO74_17660	COG1178	ABC-type Fe3 transport system permease component
LEO74_17665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEO74_17675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LEO74_17685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO74_17715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO74_17720	COG0564	pseudouridine synthase activity
LEO74_17730	COG3300	MHYT domain
LEO74_17730	COG5001	Diguanylate cyclase
LEO74_17740	COG0459	protein refolding
LEO74_17745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEO74_17750	COG0534	Mate efflux family protein
LEO74_17755	COG3030	protein affecting phage T7 exclusion by the F plasmid
LEO74_17760	COG1027	Aspartate ammonia-lyase
LEO74_17765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO74_17775	COG0477	Major facilitator Superfamily
LEO74_17790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO74_17795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO74_17805	COG0673	inositol 2-dehydrogenase activity
LEO74_17815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEO74_17820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO74_17825	COG3036	rescue of stalled ribosome
LEO74_17830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LEO74_17840	COG0138	bifunctional purine biosynthesis protein purh
LEO74_17845	COG0151	Belongs to the GarS family
LEO74_17870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO74_17875	COG0358	DNA primase activity
LEO74_17880	COG1610	YqeY-like protein
LEO74_17885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEO74_17890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEO74_17905	COG1238	metal cluster binding
LEO74_17910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO74_17915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEO74_17920	COG0585	pseudouridine synthase activity
LEO74_17930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEO74_17935	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LEO74_17940	COG0148	phosphopyruvate hydratase activity
LEO74_17945	COG0504	CTP synthase activity
LEO74_17950	COG3956	TIGRFAM MazG family protein
LEO74_17955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO74_17960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO74_17970	COG4807	Protein conserved in bacteria
LEO74_17975	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEO74_17980	COG1349	DNA-binding transcription factor activity
LEO74_17990	COG2222	sugar isomerase
LEO74_17995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_18005	COG3716	PTS system mannose fructose sorbose family IID component
LEO74_18010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_18015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO74_18030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEO74_18035	COG1381	Involved in DNA repair and RecF pathway recombination
LEO74_18045	COG0571	ribonuclease III activity
LEO74_18050	COG0681	Belongs to the peptidase S26 family
LEO74_18055	COG0481	GTPase activity
LEO74_18070	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LEO74_18075	COG1595	DNA-templated transcription, initiation
LEO74_18080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEO74_18090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LEO74_18130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO74_18140	COG0126	phosphoglycerate kinase activity
LEO74_18145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO74_18150	COG1940	carbohydrate kinase activity
LEO74_18155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEO74_18170	COG4991	sh3 domain protein
LEO74_18175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO74_18190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LEO74_18210	COG1505	serine-type exopeptidase activity
LEO74_18215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO74_18220	COG0765	amino acid transport
LEO74_18225	COG0765	amino acid transport
LEO74_18230	COG1126	abc transporter atp-binding protein
LEO74_18235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_18240	COG1136	(ABC) transporter
LEO74_18240	COG0577	efflux transmembrane transporter activity
LEO74_18245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO74_18250	COG0745	RESPONSE REGULATOR receiver
LEO74_18255	COG2205	protein histidine kinase activity
LEO74_18260	COG2816	NAD+ diphosphatase activity
LEO74_18295	COG2070	2-Nitropropane dioxygenase
LEO74_18320	COG1858	cytochrome C peroxidase
LEO74_18325	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LEO74_18350	COG0513	Belongs to the DEAD box helicase family
LEO74_18370	COG0154	amidase activity
LEO74_18375	COG2957	Belongs to the agmatine deiminase family
LEO74_18385	COG2852	Protein conserved in bacteria
LEO74_18395	COG1902	pentaerythritol trinitrate reductase activity
LEO74_18430	COG5001	Diguanylate cyclase
LEO74_18430	COG3300	MHYT domain
LEO74_18440	COG0714	Associated with various cellular activities
LEO74_18450	COG0456	acetyltransferase
LEO74_18460	COG1022	Amp-dependent synthetase and ligase
LEO74_18470	COG2918	glutathione biosynthetic process
LEO74_18475	COG0612	Peptidase, M16
LEO74_18480	COG1238	metal cluster binding
LEO74_18505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO74_18510	COG0359	binds to the 23S rRNA
LEO74_18515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEO74_18520	COG0360	Binds together with S18 to 16S ribosomal RNA
LEO74_18525	COG1914	H( )-stimulated, divalent metal cation uptake system
LEO74_18545	COG2153	protein acetylation
LEO74_18555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO74_18560	COG0557	exoribonuclease II activity
LEO74_18565	COG3706	GGDEF domain
LEO74_18570	COG1854	S-ribosylhomocysteine lyase activity
LEO74_18585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEO74_18585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO74_18625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEO74_18630	COG1047	Peptidyl-prolyl cis-trans
LEO74_18635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEO74_18640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEO74_18645	COG0196	riboflavin kinase activity
LEO74_18655	COG0728	peptidoglycan biosynthetic process
LEO74_18660	COG0268	Binds directly to 16S ribosomal RNA
LEO74_18665	COG0640	Transcriptional regulator
LEO74_18670	COG0583	DNA-binding transcription factor activity
LEO74_18680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO74_18685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEO74_18690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEO74_18700	COG1051	belongs to the nudix hydrolase family
LEO74_18705	COG3066	DNA modification
LEO74_18715	COG0335	large ribosomal subunit rRNA binding
LEO74_18720	COG0336	Belongs to the RNA methyltransferase TrmD family
LEO74_18725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEO74_18730	COG0228	four-way junction DNA binding
LEO74_18735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEO74_18740	COG4137	Cytochrome C assembly protein
LEO74_18745	COG4536	flavin adenine dinucleotide binding
LEO74_18750	COG1959	2 iron, 2 sulfur cluster binding
LEO74_18755	COG1017	nitric oxide dioxygenase activity
LEO74_18755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO74_18760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LEO74_18765	COG0039	L-malate dehydrogenase activity
LEO74_18770	COG4160	amino acid transport
LEO74_18775	COG4215	(ABC) transporter
LEO74_18780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO74_18785	COG1126	abc transporter atp-binding protein
LEO74_18790	COG1438	arginine binding
LEO74_18795	COG2837	iron assimilation
LEO74_18800	COG3842	ATPase activity
LEO74_18810	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO74_18815	COG0347	Belongs to the P(II) protein family
LEO74_18830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO74_18835	COG0583	DNA-binding transcription factor activity
LEO74_18850	COG1929	Belongs to the glycerate kinase type-1 family
LEO74_18855	COG2610	gluconate transmembrane transporter activity
LEO74_18860	COG3835	regulator
LEO74_18870	COG3112	Uncharacterised protein family (UPF0231)
LEO74_18885	COG0840	transmembrane signaling receptor activity
LEO74_18905	COG0513	Belongs to the DEAD box helicase family
LEO74_18945	COG1448	Aminotransferase
LEO74_18960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO74_18965	COG1328	CTP reductase activity
LEO74_18985	COG4946	Tricorn protease homolog
LEO74_18985	COG0793	Belongs to the peptidase S41A family
LEO74_19020	COG3397	chitin binding
LEO74_19025	COG0583	DNA-binding transcription factor activity
LEO74_19030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEO74_19035	COG4208	sulfate ABC transporter
LEO74_19040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEO74_19050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEO74_19055	COG3174	membrane
LEO74_19060	COG0110	maltose O-acetyltransferase activity
LEO74_19085	COG0165	Argininosuccinate lyase
LEO74_19090	COG0137	argininosuccinate synthase activity
LEO74_19100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO74_19105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEO74_19115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEO74_19120	COG0460	homoserine dehydrogenase
LEO74_19120	COG0527	aspartate kinase activity
LEO74_19125	COG0626	cystathionine gamma-synthase activity
LEO74_19135	COG3708	Transcriptional regulator
LEO74_19135	COG2207	Transcriptional regulator
LEO74_19140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO74_19145	COG0814	amino acid
LEO74_19150	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO74_19155	COG0494	nUDIX hydrolase
LEO74_19160	COG1011	Hydrolase
LEO74_19165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO74_19180	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LEO74_19190	COG3156	type II secretion system protein K
LEO74_19195	COG4795	General secretion pathway protein
LEO74_19200	COG2165	general secretion pathway protein
LEO74_19210	COG2165	general secretion pathway protein
LEO74_19215	COG1459	type II secretion system
LEO74_19220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO74_19230	COG3031	protein transport across the cell outer membrane
LEO74_19240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEO74_19245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEO74_19265	COG0456	acetyltransferase
LEO74_19270	COG3133	Outer membrane lipoprotein
LEO74_19285	COG2771	luxR family
LEO74_19290	COG3916	Acyl-homoserine-lactone synthase
LEO74_19300	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LEO74_19305	COG1309	transcriptional regulator
LEO74_19315	COG2213	PTS system mannitol-specific
LEO74_19315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO74_19320	COG0246	Mannitol dehydrogenase
LEO74_19325	COG3722	fumarate hydratase activity
LEO74_19330	COG3263	regulation of cellular component size
LEO74_19355	COG1671	Belongs to the UPF0178 family
LEO74_19370	COG1988	membrane-bound metal-dependent
LEO74_19375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO74_19385	COG0513	Belongs to the DEAD box helicase family
LEO74_19410	COG1575	Belongs to the MenA family. Type 1 subfamily
LEO74_19415	COG1169	isochorismate synthase
LEO74_19420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEO74_19425	COG0596	Alpha beta hydrolase
LEO74_19430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEO74_19435	COG1441	menaquinone biosynthetic process
LEO74_19440	COG0318	PFAM AMP-dependent synthetase and ligase
LEO74_19455	COG3539	Fimbrial protein
LEO74_19460	COG3121	Chaperone
LEO74_19465	COG3188	usher protein
LEO74_19485	COG3291	Pkd domain containing protein
LEO74_19490	COG2949	membrane
LEO74_19495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEO74_19505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO74_19510	COG5380	lipid catabolic process
LEO74_19525	COG4533	DNA binding
LEO74_19535	COG2873	o-acetylhomoserine
LEO74_19545	COG1979	alcohol dehydrogenase
LEO74_19565	COG4221	oxidoreductase activity
LEO74_19585	COG1285	pathogenesis
LEO74_19605	COG1368	sulfuric ester hydrolase activity
LEO74_19610	COG1522	sequence-specific DNA binding
LEO74_19620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEO74_19625	COG1418	mRNA catabolic process
LEO74_19630	COG1546	Belongs to the CinA family
LEO74_19630	COG1058	Belongs to the CinA family
LEO74_19640	COG0842	Transport permease protein
LEO74_19640	COG1129	ABC transporter
LEO74_19655	COG0561	phosphatase activity
LEO74_19660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO74_19680	COG1011	Hydrolase
LEO74_19695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEO74_19700	COG0019	diaminopimelate decarboxylase activity
LEO74_19710	COG1965	Belongs to the frataxin family
LEO74_19715	COG0400	carboxylic ester hydrolase activity
LEO74_19720	COG3072	Adenylate cyclase
LEO74_19725	COG0181	hydroxymethylbilane synthase activity
LEO74_19735	COG2959	enzyme of heme biosynthesis
LEO74_19750	COG1494	fructose-1,6-bisphosphatase
LEO74_19790	COG1733	regulation of RNA biosynthetic process
LEO74_19810	COG3932	Exopolysaccharide synthesis, ExoD
LEO74_19815	COG0814	amino acid
LEO74_19820	COG3706	GGDEF domain
LEO74_19840	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LEO74_19855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO74_19860	COG2022	thiamine diphosphate biosynthetic process
LEO74_19870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO74_19875	COG0352	thiamine-phosphate diphosphorylase activity
LEO74_19880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEO74_19905	COG0745	RESPONSE REGULATOR receiver
LEO74_19910	COG0642	Histidine kinase
LEO74_19920	COG0189	ligase activity
LEO74_19945	COG1639	'signal transduction protein
LEO74_19955	COG2321	neutral zinc metallopeptidase
LEO74_19960	COG3700	Belongs to the class B bacterial acid phosphatase family
LEO74_19980	COG1366	Belongs to the anti-sigma-factor antagonist family
LEO74_19985	COG2172	sigma factor antagonist activity
LEO74_19990	COG2205	protein histidine kinase activity
LEO74_19990	COG5002	protein histidine kinase activity
LEO74_19990	COG0784	Response regulator, receiver
LEO74_19995	COG3437	response regulator, receiver
LEO74_20005	COG0477	Major facilitator Superfamily
LEO74_20025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LEO74_20030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO74_20030	COG1263	PTS System
LEO74_20050	COG0312	modulator of DNA gyrase
LEO74_20055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO74_20065	COG3164	Protein of unknown function
LEO74_20070	COG1530	ribonuclease E activity
LEO74_20075	COG0424	maF-like protein
LEO74_20080	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LEO74_20085	COG1792	Involved in formation and maintenance of cell shape
LEO74_20090	COG1077	Cell shape determining protein MreB Mrl
LEO74_20125	COG2165	general secretion pathway protein
LEO74_20135	COG1459	type II secretion system
LEO74_20140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO74_20185	COG2200	EAL domain
LEO74_20185	COG2199	diguanylate cyclase activity
LEO74_20190	COG2200	EAL domain
LEO74_20195	COG0387	Pfam Sodium calcium exchanger
LEO74_20200	COG2986	histidine ammonia-lyase
LEO74_20205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LEO74_20210	COG0010	Belongs to the arginase family
LEO74_20215	COG1228	amidohydrolase
LEO74_20220	COG2188	Transcriptional regulator
LEO74_20225	COG0288	reversible hydration of carbon dioxide
LEO74_20235	COG2177	Part of the ABC transporter FtsEX involved in
LEO74_20240	COG2884	Cell division ATP-binding protein ftsE
LEO74_20245	COG0552	protein localization to endoplasmic reticulum
LEO74_20250	COG0742	ribosomal rna small subunit methyltransferase
LEO74_20275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO74_20285	COG0741	lytic transglycosylase activity
LEO74_20295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO74_20305	COG2095	MarC family integral membrane protein
LEO74_20315	COG1301	dicarboxylic acid transport
LEO74_20340	COG3714	YhhN family
LEO74_20360	COG1770	oligopeptidase
LEO74_20375	COG4221	oxidoreductase activity
LEO74_20380	COG0583	DNA-binding transcription factor activity
LEO74_20385	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO74_20430	COG0203	ribosomal protein L17
LEO74_20435	COG0202	RNA polymerase activity
LEO74_20440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEO74_20445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEO74_20450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEO74_20455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO74_20460	COG0201	protein transport
LEO74_20465	COG0200	Binds to the 23S rRNA
LEO74_20470	COG1841	ribosomal large subunit assembly
LEO74_20475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEO74_20480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEO74_20485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEO74_20490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEO74_20495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEO74_20500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEO74_20505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEO74_20510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEO74_20515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEO74_20520	COG0255	Belongs to the universal ribosomal protein uL29 family
LEO74_20525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEO74_20530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEO74_20535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEO74_20540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEO74_20545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEO74_20550	COG0089	rRNA binding
LEO74_20555	COG0088	Forms part of the polypeptide exit tunnel
LEO74_20560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEO74_20565	COG0051	transcription antitermination factor activity, RNA binding
LEO74_20585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO74_20590	COG2183	response to ionizing radiation
LEO74_20610	COG0596	Alpha beta hydrolase
LEO74_20615	COG1040	competence protein
LEO74_20620	COG0316	Belongs to the HesB IscA family
LEO74_20620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEO74_20625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEO74_20630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LEO74_20635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO74_20640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEO74_20645	COG4942	peptidase
LEO74_20655	COG1609	Transcriptional regulator
LEO74_20660	COG0800	Aldolase
LEO74_20670	COG3265	gluconokinase activity
LEO74_20675	COG2610	gluconate transmembrane transporter activity
LEO74_20680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO74_20685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEO74_20695	COG0456	acetyltransferase
LEO74_20705	COG1490	D-aminoacyl-tRNA deacylase activity
LEO74_20715	COG1295	ribonuclease BN
LEO74_20720	COG1217	gtp-binding protein TYPA
LEO74_20725	COG0174	glutamine synthetase
LEO74_20735	COG3852	Histidine kinase
LEO74_20740	COG2204	response regulator
LEO74_20745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO74_20750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO74_20760	COG3078	GTPase activator activity
LEO74_20770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO74_20780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEO74_20785	COG0408	coproporphyrinogen oxidase activity
LEO74_20790	COG0009	L-threonylcarbamoyladenylate synthase
LEO74_20800	COG0551	DNA topoisomerase type I activity
LEO74_20805	COG2922	Belongs to the Smg family
LEO74_20810	COG0758	DNA mediated transformation
LEO74_20820	COG0242	peptide deformylase activity
LEO74_20825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO74_20830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO74_20830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO74_20835	COG0569	domain protein
LEO74_20840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO74_20845	COG1322	Protein conserved in bacteria
LEO74_20865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO74_20870	COG0686	Belongs to the AlaDH PNT family
LEO74_20875	COG0519	Catalyzes the synthesis of GMP from XMP
LEO74_20875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO74_20885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO74_20890	COG1396	sequence-specific DNA binding
LEO74_20895	COG1012	belongs to the aldehyde dehydrogenase family
LEO74_20905	COG2962	Rard protein
LEO74_20915	COG1280	lysine exporter protein (LysE YggA)
LEO74_20925	COG0840	transmembrane signaling receptor activity
LEO74_20930	COG2391	methyltransferase activity
LEO74_20935	COG1280	lysine exporter protein (LysE YggA)
LEO74_20990	COG0583	DNA-binding transcription factor activity
LEO74_20995	COG1943	Transposase
LEO74_21015	COG0210	DNA helicase
LEO74_21030	COG1744	ABC transporter substrate-binding protein PnrA-like
LEO74_21035	COG3845	ABC transporter
LEO74_21040	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEO74_21045	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEO74_21050	COG0583	DNA-binding transcription factor activity
LEO74_21070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEO74_21075	COG0385	Bile acid
LEO74_21080	COG0531	amino acid
LEO74_21085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO74_21090	COG0531	amino acid
LEO74_21095	COG2731	YhcH YjgK YiaL family protein
LEO74_21100	COG3250	beta-galactosidase activity
LEO74_21105	COG1609	Transcriptional regulator
LEO74_21140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEO74_21145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO74_21145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO74_21150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LEO74_21155	COG3074	FtsZ-dependent cytokinesis
LEO74_21165	COG1045	serine acetyltransferase
LEO74_21175	COG0745	RESPONSE REGULATOR receiver
LEO74_21180	COG2205	protein histidine kinase activity
LEO74_21185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEO74_21190	COG0534	Mate efflux family protein
LEO74_21205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO74_21210	COG2937	Belongs to the GPAT DAPAT family
LEO74_21215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEO74_21220	COG3161	chorismate lyase activity
LEO74_21225	COG1580	Controls the rotational direction of flagella during chemotaxis
LEO74_21240	COG0604	alcohol dehydrogenase
LEO74_21245	COG1609	Transcriptional regulator
LEO74_21265	COG1519	Transferase
LEO74_21270	COG0859	PFAM glycosyl transferase family 9
LEO74_21275	COG0463	Glycosyl transferase, family 2
LEO74_21280	COG0859	PFAM glycosyl transferase family 9
LEO74_21285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEO74_21290	COG2990	Protein conserved in bacteria
LEO74_21295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEO74_21305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEO74_21310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEO74_21315	COG2003	Belongs to the UPF0758 family
LEO74_21320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEO74_21325	COG0756	dUTP diphosphatase activity
LEO74_21330	COG1309	transcriptional regulator
LEO74_21335	COG0668	transmembrane transport
LEO74_21345	COG0166	Belongs to the GPI family
LEO74_21350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEO74_21355	COG0583	DNA-binding transcription factor activity
LEO74_21370	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO74_21370	COG1042	CoA-binding domain protein
LEO74_21370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO74_21400	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LEO74_21405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO74_21410	COG1739	Uncharacterized protein family UPF0029
LEO74_21415	COG0006	proline dipeptidase activity
LEO74_21420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO74_21425	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO74_21425	COG1024	Enoyl-CoA hydratase
LEO74_21430	COG0183	Belongs to the thiolase family
LEO74_21455	COG0425	Belongs to the sulfur carrier protein TusA family
LEO74_21460	COG0251	oxidation-reduction process
LEO74_21465	COG2885	chlorophyll binding
LEO74_21475	COG2818	Glycosylase
LEO74_21480	COG0752	glycyl-tRNA synthetase alpha subunit
LEO74_21485	COG0751	glycine-tRNA ligase activity
LEO74_21500	COG0194	GDP metabolic process
LEO74_21520	COG0814	amino acid
LEO74_21525	COG0348	domain, Protein
LEO74_21535	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO74_21540	COG1773	rubredoxin
LEO74_21540	COG0426	domain, Protein
LEO74_21545	COG3604	Transcriptional regulator
LEO74_21550	COG2188	Transcriptional regulator
LEO74_21565	COG1609	Transcriptional regulator
LEO74_21605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO74_21630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEO74_21645	COG3118	belongs to the thioredoxin family
LEO74_21650	COG0513	Belongs to the DEAD box helicase family
LEO74_21655	COG0248	Ppx GppA phosphatase
LEO74_21665	COG0742	ribosomal rna small subunit methyltransferase
LEO74_21685	COG0084	hydrolase, TatD family'
LEO74_21690	COG0805	protein transport
LEO74_21695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO74_21705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEO74_21710	COG3165	ubiquinone biosynthetic process from chorismate
LEO74_21720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEO74_21725	COG0402	S-adenosylhomocysteine deaminase activity
LEO74_21770	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LEO74_21775	COG0848	biopolymer transport protein
LEO74_21780	COG0811	peptide transport
LEO74_21785	COG0811	peptide transport
LEO74_21795	COG2771	luxR family
LEO74_21800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEO74_21805	COG1349	DNA-binding transcription factor activity
LEO74_21810	COG0745	RESPONSE REGULATOR receiver
LEO74_21815	COG2205	protein histidine kinase activity
LEO74_21825	COG4452	Inner membrane protein CreD
LEO74_21830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO74_21835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEO74_21840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEO74_21845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEO74_21850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEO74_21855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEO74_21860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEO74_21870	COG0356	it plays a direct role in the translocation of protons across the membrane
LEO74_21880	COG1475	DNA binding
LEO74_21885	COG1192	Involved in chromosome partitioning
LEO74_21890	COG0357	Ribosomal RNA small subunit methyltransferase G
LEO74_21895	COG0445	tRNA wobble uridine modification
LEO74_21900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO74_21905	COG4774	siderophore transport
LEO74_21910	COG4615	Cyclic peptide transporter
LEO74_21915	COG1120	ATPase activity
LEO74_21930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEO74_21935	COG0706	membrane insertase activity
LEO74_21940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEO74_21945	COG0594	ribonuclease P activity
LEO74_21950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LEO74_21955	COG1126	abc transporter atp-binding protein