locus-tag class description TK34_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) TK34_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TK34_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TK34_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TK34_00035 ENOG4108ZNX Heat shock protein TK34_00040 ENOG4108ZNX Heat shock protein TK34_00045 ENOG4105JKW Valine--pyruvate aminotransferase TK34_00065 ENOG4105EEX Two component transcriptional regulator (Winged helix family TK34_00070 ENOG4105C08 Histidine kinase TK34_00080 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) TK34_00085 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) TK34_00090 ENOG4105DC8 reductase TK34_00095 ENOG4105BZU Histidine kinase TK34_00100 ENOG4105BZS acriflavin resistance protein TK34_00105 ENOG410624X efflux transporter, rnd family, mfp subunit TK34_00140 ENOG4105DQF Hydrolase TK34_00145 ENOG4108EUD Lysophospholipase TK34_00150 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase TK34_00155 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TK34_00160 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) TK34_00170 ENOG4105DKP glycosyl transferase, family 9 TK34_00175 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) TK34_00185 ENOG4105EMK carboxylate amino acid amine transporter TK34_00210 ENOG4108M6U Universal stress protein A TK34_00215 ENOG4105RKW reductase (By TK34_00220 ENOG4105BZU Histidine kinase TK34_00225 ENOG41090A1 ferritin TK34_00230 ENOG4105CBX hi0933 family TK34_00235 ENOG4105EU0 Major facilitator Superfamily TK34_00245 ENOG4108HRK Histidine kinase TK34_00250 ENOG4105DY9 regulatoR TK34_00255 ENOG4105FCD Major Facilitator TK34_00260 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit TK34_00265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TK34_00280 ENOG41063Z6 transcriptional regulator, lysR family TK34_00285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) TK34_00290 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TK34_00330 ENOG4105CUZ uba thif-type nad fad binding protein TK34_00335 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) TK34_00340 ENOG4105C9B Cysteine desulfurase TK34_00345 ENOG4105C4R Atp-dependent dna helicase TK34_00350 ENOG4105BZU Histidine kinase TK34_00355 ENOG4105MPD Cytochrome TK34_00360 ENOG4105CPQ Dehydrogenase TK34_00365 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TK34_00370 ENOG41062JF Transcriptional regulator TK34_00375 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) TK34_00390 ENOG4105W1T Glycosyl Transferase TK34_00410 ENOG4105DSJ YicC domain protein TK34_00415 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) TK34_00420 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) TK34_00440 ENOG4105PC1 Conserved Protein TK34_00450 ENOG4105E27 serine threonine protein kinase TK34_00455 ENOG4108Z33 Thiol disulfide Interchange Protein TK34_00460 ENOG4105S7S phosphonate abc transporter TK34_00465 ENOG4108VA1 ABC transporter TK34_00470 ENOG4105EHI Phosphonate ABC transporter, periplasmic TK34_00475 ENOG4107RH7 Nicotinate phosphoribosyltransferase TK34_00480 ENOG4108RWI nicotinamidase TK34_00490 ENOG4105EWC Purine nucleoside phosphorylase TK34_00495 ENOG4106HNH Acyl-transferase TK34_00500 ENOG4106HNH Acyl-transferase TK34_00565 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit TK34_00570 ENOG4105CM2 brancheD-chain amino acid aminotransferase TK34_00575 ENOG4105C01 Dihydroxy-acid dehydratase TK34_00580 ENOG4105C7B Threonine dehydratase TK34_00585 ENOG4105UYK outer membrane protein a TK34_00595 ENOG4105C25 Primosomal protein n' TK34_00600 ENOG4105VFB Binds the 23S rRNA (By similarity) TK34_00605 ENOG4105CGD Nad-dependent epimerase dehydratase TK34_00610 ENOG4105C6K Malic enzyme TK34_00620 ENOG4105JJR Histidine kinase TK34_00625 ENOG4107EXC regulatoR TK34_00630 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) TK34_00665 ENOG4105EQQ protein containing aminopeptidase domain TK34_00685 ENOG4105D2T synthase TK34_00695 ENOG4105F0R Cytidylyltransferase TK34_00710 ENOG4105CHR reductase TK34_00715 ENOG4105CEY Amp-dependent synthetase and ligase TK34_00730 ENOG4105CND Glycosyl transferase, family 2 TK34_00745 ENOG4105P12 pyruvate phosphate dikinase TK34_00750 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TK34_00755 ENOG4105C5E polysaccharide biosynthesis protein TK34_00760 ENOG4107R28 alpha amylase, catalytic region TK34_00775 ENOG4105R8A Heat shock protein TK34_00780 ENOG4105C5I Dehydrogenase TK34_00785 ENOG4108RH0 Crea protein TK34_00800 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters TK34_00805 ENOG4105CFQ glutamine synthetase TK34_00810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TK34_00820 ENOG4108HM4 ABC transporter TK34_00825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TK34_00830 ENOG4105F38 ABC transporter, permease TK34_00835 ENOG4105D38 putrescine abc transporter TK34_00840 ENOG4108RPX mosc domain containing protein TK34_00855 ENOG4108VUY thioesterase Superfamily protein TK34_00860 ENOG4105C9U ATP-dependent DNA helicase RecQ TK34_00865 ENOG4105N7H Cytochrome TK34_00870 ENOG4105CNG UPF0061 protein TK34_00880 ENOG4105EX9 Membrane TK34_00885 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) TK34_00890 ENOG4108NVR Methyl-accepting chemotaxis TK34_00895 ENOG4105CJW magnesium transporter TK34_00900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TK34_00905 ENOG4107V9H nitrite transporter TK34_00910 ENOG4105WZK nitrite reductase NADPH small subunit TK34_00915 ENOG4107QZF nitrite reductase NADPH large subunit TK34_00925 ENOG4105C57 major facilitator superfamily TK34_00930 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) TK34_00935 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) TK34_00945 ENOG4105C75 arginyL-tRNA synthetase TK34_00955 ENOG4105K6V RNA polymerase TK34_00960 ENOG4108NIX Factor ChrR TK34_00965 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TK34_00970 ENOG4105CPC Aldo Keto reductase TK34_00975 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) TK34_00980 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TK34_00985 ENOG4105F0Z galactose-1-phosphate uridylyltransferase TK34_00990 ENOG4105CMR udp-glucose 4-epimerase TK34_00995 ENOG41060NJ transcriptional regulator TK34_01000 ENOG4105CNT hydrolase family 2 TK34_01015 ENOG4107SDZ Galactoside transport system permease protein mglC TK34_01020 ENOG4105C8Q Methyl-accepting chemotaxis TK34_01040 ENOG4105C5B carbamate kinase TK34_01045 ENOG4105DBV ornithine carbamoyltransferase TK34_01050 ENOG4105CSX c4-dicarboxylate anaerobic carrier TK34_01055 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) TK34_01060 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) TK34_01065 ENOG4105CXT aspartate transcarbamylase TK34_01080 ENOG4105DJ4 phosphatidylserine decarboxylase TK34_01085 ENOG4105C8Q Methyl-accepting chemotaxis TK34_01090 ENOG4105QNF Outer membrane lipoprotein TK34_01095 ENOG4105CF7 AraC family transcriptional regulator TK34_01100 ENOG4108I6A alcohol dehydrogenase TK34_01105 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TK34_01110 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TK34_01120 ENOG4105CEM UPF0597 protein TK34_01130 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TK34_01135 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane TK34_01140 ENOG4105C34 Pseudouridine synthase TK34_01145 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase TK34_01150 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TK34_01155 ENOG4107T8T UPF0173 metal-dependent hydrolase TK34_01160 ENOG4105CU9 asparagine synthetase A TK34_01165 ENOG4108VVK transcriptional Regulator, AsnC TK34_01180 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TK34_01185 ENOG410642E Short chain dehydrogenase TK34_01195 ENOG4107WP9 Histidine kinase TK34_01205 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_01210 ENOG4108UQ5 membrane protein YcdZ TK34_01220 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) TK34_01235 ENOG4105XJC Two component transcriptional regulator (Winged helix family TK34_01240 ENOG4105IFJ Histidine kinase TK34_01250 ENOG4107QY8 reductase TK34_01255 ENOG4105CUW cytochrome C-TYPE protein TK34_01260 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TK34_01275 ENOG4105E7U AraC family transcriptional regulator TK34_01285 ENOG4107ZYR domain protein TK34_01290 ENOG4105D4A Cell wall formation (By similarity) TK34_01295 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase TK34_01300 ENOG4105CS9 pantothenic acid kinase TK34_01315 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TK34_01325 ENOG4105PM1 preprotein translocase subunit SecE TK34_01330 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TK34_01335 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TK34_01340 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) TK34_01345 ENOG4108VZM 50s ribosomal protein L10 TK34_01350 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TK34_01355 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TK34_01360 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TK34_01365 ENOG4105WWK YheO domain protein TK34_01370 ENOG4105KME endoribonuclease L-psp TK34_01380 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) TK34_01385 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) TK34_01395 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TK34_01400 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TK34_01415 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase TK34_01455 ENOG4105C7N Xanthine uracil vitamin C permease TK34_01460 ENOG4105CMT Dihydroxyacetone kinase TK34_01465 ENOG4108UTZ Dihydroxyacetone kinase TK34_01480 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family TK34_01485 ENOG4105ETT transcriptional Regulator, LysR family TK34_01490 ENOG4105DWY Agmatine deiminase TK34_01495 ENOG4105EMU Dehydrogenase TK34_01500 ENOG4105IPI Membrane TK34_01530 ENOG4105CH6 catalase TK34_01535 ENOG4105WCN acetyltransferase TK34_01555 ENOG4105BZU Histidine kinase TK34_01565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TK34_01575 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component TK34_01600 ENOG4105CWB LysR family transcriptional Regulator TK34_01610 ENOG4105C2I pirin domain protein TK34_01615 ENOG4108VBZ doxx family TK34_01625 ENOG4105DSY exodeoxyribonuclease V, gamma TK34_01630 ENOG4107QKA exodeoxyribonuclease V beta TK34_01635 ENOG4107QYX exodeoxyribonuclease v alpha TK34_01640 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase TK34_01660 ENOG4108NVR Methyl-accepting chemotaxis TK34_01680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TK34_01685 ENOG4105E0F Histidine kinase TK34_01695 ENOG4105D05 Receptor TK34_01705 ENOG4105VEQ Cold shock protein TK34_01715 ENOG41076HS cation diffusion facilitator family transporter TK34_01725 ENOG4108UUM single-stranded DNA-binding protein TK34_01730 ENOG41086KC Transcriptional regulator TK34_01735 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TK34_01740 ENOG4105BZU Histidine kinase TK34_01745 ENOG4105EIF outer membrane protein W TK34_01750 ENOG4105C8Q Methyl-accepting chemotaxis TK34_01765 ENOG4105SYT Methylenetetrahydrofolate reductase TK34_01775 ENOG4105DKK Benzoate TK34_01780 ENOG4108JCI Transcriptional regulator TK34_01810 ENOG41090HJ UPF0265 protein TK34_01820 ENOG4105N42 UPF0307 protein TK34_01825 ENOG4105CMS peptidase U62, modulator of DNA gyrase TK34_01830 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TK34_01835 ENOG4105VFK BolA family TK34_01845 ENOG4105E3I toluene tolerance TK34_01850 ENOG4107PE3 Mammalian cell entry related domain protein TK34_01855 ENOG4105CY3 ABC transporter, permease TK34_01860 ENOG4105DHJ ABC, transporter TK34_01865 ENOG4105C2X Arabinose 5-phosphate isomerase TK34_01870 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase TK34_01875 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) TK34_01880 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA TK34_01885 ENOG4108IUZ ABC transporter TK34_01890 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TK34_01895 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA TK34_01900 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN TK34_01905 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) TK34_01910 ENOG41080Z8 PHOSPHOCARRIER protein TK34_01915 ENOG4105EMD TRANSCRIPTIONal TK34_01930 ENOG41069H0 dihydroorotase EC 3.5.2.3 TK34_01960 ENOG4105C0H protease TK34_01965 ENOG4105C0H protease TK34_01975 ENOG4105D6Z AFG1 family ATPase TK34_01980 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TK34_01985 ENOG4108UJD 30S ribosomal protein S9 TK34_01990 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) TK34_01995 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) TK34_02000 ENOG4105EIX cytochrome c1 TK34_02005 ENOG4107MKT Stringent starvation protein a TK34_02010 ENOG4105KB2 stringent starvation protein b TK34_02015 ENOG4105W4M Transport-associated protein TK34_02020 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) TK34_02025 ENOG41082RQ UPF0102 protein TK34_02030 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) TK34_02035 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) TK34_02045 ENOG4105DD5 Flagellar motor switch protein TK34_02050 ENOG4105CN7 Flagellar biosynthetic protein FliP TK34_02055 ENOG4105VS8 Flagellar biosynthetic protein fliq TK34_02060 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TK34_02065 ENOG4105D00 flagellar biosynthetic protein flhB TK34_02075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_02080 ENOG4105VQ0 flagellar hook-basal body complex protein fliE TK34_02085 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) TK34_02090 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TK34_02100 ENOG4108JIR Flagellum-specific ATP synthase TK34_02125 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TK34_02130 ENOG4108ZC9 flagellar basal-body rod protein flgc TK34_02135 ENOG4105W00 Flagellar hook capping protein TK34_02140 ENOG4105BZE flagellar hook protein, FlgE TK34_02145 ENOG4108KPB Flagellar basal-body rod protein FlgF TK34_02150 ENOG4105CGA flagellar basal-body rod protein FlgG TK34_02155 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) TK34_02160 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) TK34_02170 ENOG4105E1Q flagellar hook-associated protein TK34_02175 ENOG4105DTJ flagellar hook-associated protein TK34_02195 ENOG4105I03 Flagellin TK34_02200 ENOG410804A Flagellar hook-associated 2 domain-containing protein TK34_02205 ENOG4105MQ3 flagellar protein FliS TK34_02230 ENOG4107RD7 Flagellar Motor Protein, MotA TK34_02235 ENOG4105ER2 Ompa motb domain protein TK34_02240 ENOG4105E9H Lytic Murein transglycosylase TK34_02250 ENOG4108V6E Cell division protein mraZ TK34_02255 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TK34_02260 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) TK34_02265 ENOG4105CJN penicillin-binding protein TK34_02270 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TK34_02275 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) TK34_02280 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TK34_02285 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) TK34_02290 ENOG4105CNI cell division protein FtsW TK34_02295 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TK34_02300 ENOG4105DFU Cell wall formation (By similarity) TK34_02305 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) TK34_02310 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TK34_02315 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TK34_02320 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) TK34_02330 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TK34_02340 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TK34_02350 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) TK34_02355 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) TK34_02370 ENOG4105D7Q type ii secretion system TK34_02375 ENOG4107QHF type ii secretion system protein e TK34_02390 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase TK34_02405 ENOG41073TP transcriptional regulator TK34_02410 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) TK34_02415 ENOG4107QSN dihydrolipoamide acetyltransferase TK34_02420 ENOG4107QN2 dihydrolipoyl dehydrogenase TK34_02425 ENOG4105BZU Histidine kinase TK34_02435 ENOG4108N3W hemolysin secretion protein TK34_02440 ENOG4108N3W hemolysin secretion protein TK34_02445 ENOG4105D78 K07001 NTE family protein TK34_02450 ENOG4107QIJ Aconitate hydratase 2 TK34_02465 ENOG4105E82 cytochrome subunit of dehydrogenase TK34_02475 ENOG4105CKI cobalamin synthesis protein TK34_02480 ENOG4105C0R drug resistance transporter emrb qaca subfamily TK34_02490 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TK34_02495 ENOG4107ZVW dihydroneopterin aldolase TK34_02500 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) TK34_02525 ENOG4108WC9 type VI secretion system effector, hcp1 family TK34_02530 ENOG4105CS6 Rhs element vgr protein TK34_02570 ENOG4105DWD nucleoside recognition domain protein TK34_02575 ENOG4107R88 Chemotaxis protein (CheV) TK34_02585 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) TK34_02600 ENOG4108UQY Iron-storage protein TK34_02610 ENOG4108Z5K methylglyoxal synthase TK34_02625 ENOG4105HDK L-asparaginase TK34_02640 ENOG4105D4X repressor TK34_02645 ENOG4105C5Y PTS System TK34_02650 ENOG4105CG3 alpha amylase, catalytic region TK34_02655 ENOG4108UW5 maltose o-acetyltransferase TK34_02665 ENOG4107AQZ Membrane TK34_02675 ENOG4105C26 Dehydrogenase TK34_02680 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component TK34_02685 ENOG4105D81 ABC transporter, permease TK34_02690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TK34_02695 ENOG4107TYH extracellular solute-binding protein family 1 TK34_02700 ENOG4108M0I Transcriptional regulator TK34_02705 ENOG4105DFD Na H antiporter TK34_02745 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) TK34_02750 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TK34_02755 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) TK34_02760 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TK34_02775 ENOG4107VXZ Hydrolase TK34_02780 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) TK34_02785 ENOG4105F1S paraquat-inducible protein a TK34_02790 ENOG4105DY2 Paraquat-inducible protein b TK34_02795 ENOG4108Q2G (LipO)protein TK34_02800 ENOG4105UYK outer membrane protein a TK34_02815 ENOG4105H4F exported protein TK34_02825 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) TK34_02830 ENOG4105CEN a g-specific adenine glycosylase TK34_02845 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate TK34_02860 ENOG41067MG lrgb family TK34_02870 ENOG4105CMU LysR family (Transcriptional regulator TK34_02900 ENOG4108Z66 YbaK ebsC protein TK34_02905 ENOG4105CJ3 phosphate transporter TK34_02910 ENOG4107IX6 phosphate transport regulator TK34_02925 ENOG4105D1S lipid A biosynthesis TK34_02930 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) TK34_02935 ENOG4105DFG type I secretion outer membrane protein TK34_02940 ENOG41087AY ADP-Ribose pyrophosphatase TK34_02955 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) TK34_02960 ENOG4105IPS esterase TK34_02980 ENOG4105Y49 secretion protein, HlyD family TK34_02990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TK34_02995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TK34_03030 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TK34_03035 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TK34_03060 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase TK34_03065 ENOG41087YS Phage shock protein A TK34_03080 ENOG41082IR Excinuclease ABC C subunit domain protein TK34_03090 ENOG4105FR1 rard protein TK34_03095 ENOG4108RG0 uracil-dna glycosylase TK34_03105 ENOG4105ETT transcriptional Regulator, LysR family TK34_03110 ENOG4105FAV ABC, transporter TK34_03115 ENOG4105FDK ABC transporter TK34_03120 ENOG4105NXV High-affinity zinc uptake system protein TK34_03140 ENOG4105DR5 peptidase TK34_03150 ENOG4105R2J Conserved Protein TK34_03170 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) TK34_03175 ENOG4107TH8 cina domain protein TK34_03180 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) TK34_03190 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TK34_03200 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) TK34_03235 ENOG41061WM D-Alanyl-D-Alanine TK34_03240 ENOG4106W5V Membrane TK34_03250 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TK34_03255 ENOG4105MYG DNA polymerase iii, chi subunit TK34_03260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TK34_03265 ENOG4108M8S permease YjgP YjgQ family protein TK34_03270 ENOG4108K5H permease YjgP YjgQ family protein TK34_03405 ENOG4105ED4 portal protein TK34_03475 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TK34_03480 ENOG4105BZU Histidine kinase TK34_03485 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TK34_03495 ENOG4105EYA deoxyribonuclease TK34_03500 ENOG4105D9N nucleoside TK34_03510 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TK34_03515 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) TK34_03520 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) TK34_03525 ENOG4105D3A purine nucleoside phosphorylase DeoD-type TK34_03530 ENOG4105BZU Histidine kinase TK34_03540 ENOG4105EAC phosphoserine phosphatase TK34_03555 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TK34_03565 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor TK34_03570 ENOG4105K70 DNA-binding protein TK34_03580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TK34_03600 ENOG4105CWM branched-chain amino acid transport system II carrier protein TK34_03605 ENOG4105CWM branched-chain amino acid transport system II carrier protein TK34_03610 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) TK34_03615 ENOG4105C1J atp-dependent rna helicase TK34_03620 ENOG4105D1Q UPF0246 protein TK34_03625 ENOG4105CZX twitching motility protein TK34_03630 ENOG4105CZX twitching motility protein TK34_03635 ENOG4105DFA alanine racemase domain protein TK34_03640 ENOG4105II7 pyrroline-5-carboxylate reductase TK34_03645 ENOG4108VIA integral membrane protein TK34_03650 ENOG4105VZ9 UPF0235 protein TK34_03665 ENOG4107QSI ABC, transporter TK34_03675 ENOG4105EQK -acetyltransferase TK34_03685 ENOG4106WH9 Protein of unknown function (DUF2753) TK34_03690 ENOG4105E39 Enoyl-CoA hydratase TK34_03705 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr TK34_03710 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TK34_03715 ENOG4105C8Q Methyl-accepting chemotaxis TK34_03720 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TK34_03725 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TK34_03730 ENOG4105C4M (Ubiquinol oxidase) subunit I TK34_03735 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TK34_03745 ENOG4105KJB cyd operon protein YbgE TK34_03750 ENOG4107YD3 Thioesterase TK34_03755 ENOG4105E02 MotA TolQ exbB proton channel TK34_03760 ENOG4105M8F Biopolymer transport protein exbD tolR TK34_03770 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) TK34_03775 ENOG4105KCK Peptidoglycan-associated lipoprotein TK34_03780 ENOG4105UFD tol-pal system protein YbgF TK34_03855 ENOG4105C8Q Methyl-accepting chemotaxis TK34_03860 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) TK34_03865 ENOG4105DSB aldose 1-epimerase TK34_03875 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) TK34_03880 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) TK34_03890 ENOG4105E0X reductase TK34_03900 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TK34_03905 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TK34_03910 ENOG4108ZHJ Organic hydroperoxide resistance protein TK34_03915 ENOG4105K56 Transcriptional regulator TK34_03930 ENOG4105EW9 transcriptional regulator AsnC family TK34_03945 ENOG4108K4B hydrolase TK34_03960 ENOG4105C8J )-transporter TK34_03970 ENOG4105C8J )-transporter TK34_03995 ENOG4107SQD Transcriptional regulator, GntR family TK34_04015 ENOG4105E3B Multicopper oxidase TK34_04025 ENOG4105XEP YhcH YjgK YiaL family protein TK34_04035 ENOG4105CUY Mechanosensitive ion channel TK34_04040 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein TK34_04045 ENOG4105CK7 Sodium proline symporter TK34_04075 ENOG4105EQ2 LysR family Transcriptional regulator TK34_04080 ENOG4105D6S protein involved in catabolism of external DNA TK34_04090 ENOG4105C5H ABC transporter TK34_04095 ENOG4105C2X Arabinose 5-phosphate isomerase TK34_04100 ENOG4105G5H Membrane TK34_04105 ENOG4107QX8 SPFH domain, Band 7 family protein TK34_04110 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TK34_04115 ENOG4105C11 sulfate adenylyltransferase), subunit 2 TK34_04120 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) TK34_04130 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) TK34_04180 ENOG4108UUE Transcriptional regulator TK34_04195 ENOG4105F0N pyrophosphate phospho-hydrolase TK34_04200 ENOG4105DFU Cell wall formation (By similarity) TK34_04205 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase TK34_04210 ENOG410630P Transcriptional regulator TK34_04215 ENOG4108UGV hypoxanthine phosphoribosyltransferase TK34_04220 ENOG4105DA5 (ABC) transporter TK34_04225 ENOG4105E3A (ABC) transporter TK34_04230 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase TK34_04255 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) TK34_04260 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) TK34_04265 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TK34_04270 ENOG4105DJ0 Poly(A) Polymerase TK34_04275 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) TK34_04280 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters TK34_04285 ENOG4105PW4 Sugar fermentation stimulation protein homolog TK34_04295 ENOG4105CQ7 ATP-dependent helicase TK34_04300 ENOG4105BZ4 penicillin-binding protein TK34_04305 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase TK34_04310 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) TK34_04315 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) TK34_04325 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_04335 ENOG41076MN Phosphoesterase, PA-phosphatase related TK34_04350 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TK34_04355 ENOG4105CMQ Chloride channel TK34_04365 ENOG4108YX9 iron--sulfur cluster insertion protein erpA TK34_04395 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TK34_04405 ENOG4108IAB Phoh family TK34_04410 ENOG4107T0D ABC, transporter TK34_04415 ENOG4106SMU thiamine transporter membrane protein TK34_04420 ENOG4105DP9 ABC transporter TK34_04435 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TK34_04440 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TK34_04450 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) TK34_04460 ENOG4105YVM Phosphoesterase, PA-phosphatase related TK34_04470 ENOG4105C7K acetolactate synthase TK34_04475 ENOG4108ZP8 Acetolactate synthase small subunit TK34_04480 ENOG4105C6K Malic enzyme TK34_04485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TK34_04490 ENOG4105PQ6 UPF0208 membrane protein TK34_04495 ENOG4105XWI UPF0304 protein TK34_04500 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TK34_04505 ENOG4105RH4 Glycine cleavage system transcriptional repressor TK34_04510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TK34_04515 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) TK34_04520 ENOG4107QWK SAICAR synthetase TK34_04530 ENOG4105EXG Transcriptional regulator TK34_04535 ENOG4106173 Uncharacterized protein conserved in bacteria (DUF2057) TK34_04555 ENOG4105BZU Histidine kinase TK34_04560 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein TK34_04570 ENOG4105BZU Histidine kinase TK34_04575 ENOG4105BZU Histidine kinase TK34_04580 ENOG4108N3W hemolysin secretion protein TK34_04595 ENOG4105BZU Histidine kinase TK34_04600 ENOG4108N3W hemolysin secretion protein TK34_04605 ENOG4105MDZ Transcriptional activator rfaH TK34_04610 ENOG4105D01 (LipO)protein TK34_04615 ENOG4108UMI ABC transporter, permease TK34_04620 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TK34_04640 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) TK34_04645 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) TK34_04650 ENOG4105K8N protein family UPF0079, ATPase TK34_04655 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TK34_04660 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) TK34_04665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TK34_04670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) TK34_04675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TK34_04680 ENOG4107QJR hflk protein TK34_04685 ENOG4105EPW hflc protein TK34_04695 ENOG4105EAH synthase TK34_04705 ENOG4105K46 50S ribosomal protein l27 TK34_04710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TK34_04715 ENOG4105DWD nucleoside recognition domain protein TK34_04720 ENOG4105CEY Amp-dependent synthetase and ligase TK34_04735 ENOG4108ESY Metal dependent phosphohydrolase TK34_04740 ENOG4105DEN Luciferase family TK34_04750 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) TK34_04760 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TK34_04765 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) TK34_04775 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) TK34_04780 ENOG4105EHM Aminoglycoside phosphotransferase TK34_04785 ENOG4108S0S Nucleotidyl transferase TK34_04790 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) TK34_04795 ENOG4105C7N Xanthine uracil vitamin C permease TK34_04805 ENOG4105C5H ABC transporter TK34_04820 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TK34_04825 ENOG4105E4C Lytic transglycosylase catalytic TK34_04845 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) TK34_04850 ENOG4105D9N nucleoside TK34_04855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TK34_04880 ENOG4105EHG Permease protein TK34_04890 ENOG41090JE Utilization Protein TK34_04895 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related TK34_04915 ENOG4105D05 Receptor TK34_04920 ENOG4105D8G Major Facilitator superfamily TK34_04925 ENOG4105VMP Transcriptional regulator TK34_04935 ENOG4105BZU Histidine kinase TK34_04945 ENOG4108MA4 Peptidase M66 TK34_04950 ENOG4108M1A Chitin-binding protein TK34_04955 ENOG4105DHI Methyltransferase TK34_04960 ENOG4107RYR Transcriptional regulator, Crp Fnr family TK34_04965 ENOG4108UKZ OsmC family TK34_04980 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) TK34_04985 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) TK34_04990 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) TK34_04995 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) TK34_05000 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) TK34_05005 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) TK34_05010 ENOG4105CKK Glycosyl transferase, family 2 TK34_05015 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TK34_05020 ENOG4105C6Y Udp-glucose 6-dehydrogenase TK34_05025 ENOG4105YP7 UPF0270 protein TK34_05035 ENOG4105DNZ Alpha Beta Hydrolase TK34_05040 ENOG4107R88 Chemotaxis protein (CheV) TK34_05050 ENOG4105VKU nucleicacid-binding protein TK34_05055 ENOG4108YZY peptidylprolyl cis-trans isomerase TK34_05060 ENOG4105VRX Protein slyX homolog TK34_05070 ENOG4108V1T peptidylprolyl cis-trans isomerase TK34_05075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_05095 ENOG4105CGH 5'-nucleotidase TK34_05100 ENOG4105BZU Histidine kinase TK34_05110 ENOG4105CDU Replicative dna helicase TK34_05115 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TK34_05120 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding TK34_05125 ENOG4105CFP Peptidase U32 TK34_05130 ENOG4108NJZ Sensory box GGDEF EAL domain protein TK34_05160 ENOG4105C9B Cysteine desulfurase TK34_05165 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TK34_05170 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) TK34_05175 ENOG4105BZU Histidine kinase TK34_05180 ENOG4105C8Q Methyl-accepting chemotaxis TK34_05185 ENOG4108V3W Chemotaxis protein, CheW TK34_05195 ENOG4105CBS Chea signal transduction histidine kinase TK34_05205 ENOG4108VYJ response regulator receiver protein TK34_05210 ENOG4108NVR Methyl-accepting chemotaxis TK34_05215 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TK34_05225 ENOG4105N14 lysine exporter protein LysE YggA TK34_05230 ENOG4105CFP Peptidase U32 TK34_05240 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TK34_05255 ENOG4105CTD carboxy-peptidase TK34_05275 ENOG4105E1F short-chain dehydrogenase reductase TK34_05280 ENOG4105J5J Outer membrane porin TK34_05295 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) TK34_05300 ENOG4105C0A alcohol dehydrogenase TK34_05305 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) TK34_05310 ENOG4105DET Rhamnulokinase TK34_05315 ENOG4105DKG l-rhamnose isomerase TK34_05320 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) TK34_05325 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) TK34_05370 ENOG4105CHH sulfate transporter TK34_05385 ENOG410620I Diguanylate cyclase TK34_05440 ENOG4105CQC Prephenate dehydratase TK34_05470 ENOG4107SEY Conserved Protein TK34_05475 ENOG4108XDN Transcriptional regulator TK34_05480 ENOG4105CVP deoxyribo-dipyrimidine photolyase TK34_05490 ENOG4105EMU Dehydrogenase TK34_05505 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase TK34_05530 ENOG4108RMU ferritin dps family protein TK34_05535 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) TK34_05540 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) TK34_05545 ENOG4105CMR udp-glucose 4-epimerase TK34_05550 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) TK34_05560 ENOG4105D5K Hemolysin activator protein TK34_05565 ENOG41067NU TK34_05580 ENOG4105VJY transcriptional regulator TK34_05585 ENOG4108WC9 type VI secretion system effector, hcp1 family TK34_05590 ENOG4105CS6 Rhs element vgr protein TK34_05625 ENOG4105C7K acetolactate synthase TK34_05630 ENOG4107S0N DJ-1 family TK34_05635 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) TK34_05640 ENOG4108VPT UPF0234 protein TK34_05645 ENOG4105DRB nucleoside-specific channel-forming protein TK34_05650 ENOG4105EYM Major Facilitator superfamily TK34_05660 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) TK34_05670 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) TK34_05675 ENOG4105M85 Bola protein TK34_05680 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_05685 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_05690 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_05695 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_05700 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_05705 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) TK34_05710 ENOG4105CJ2 (LipO)protein TK34_05725 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TK34_05730 ENOG4105C8Q Methyl-accepting chemotaxis TK34_05735 ENOG4105ETT transcriptional Regulator, LysR family TK34_05745 ENOG4105M08 Membrane TK34_05750 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) TK34_05760 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TK34_05765 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease TK34_05770 ENOG4105EWT decarboxylase family TK34_05775 ENOG4105BZU Histidine kinase TK34_05785 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) TK34_05790 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) TK34_05795 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein TK34_05820 ENOG4105WP7 tRNA pseudouridine synthase C TK34_05825 ENOG4105DR9 pseudouridine synthase TK34_05830 ENOG4105QDK Flavodoxin TK34_05835 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) TK34_05840 ENOG4107W52 maltose operon periplasmic protein TK34_05845 ENOG4105CI1 PTS System TK34_05850 ENOG4108T8E UPF0325 protein TK34_05855 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) TK34_05860 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) TK34_05865 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TK34_05870 ENOG4105CE9 30S ribosomal protein S2 TK34_05875 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TK34_05880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TK34_05890 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TK34_05895 ENOG4105KNE Phosphatidate cytidylyltransferase TK34_05900 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TK34_05905 ENOG4105DZP Membrane-associated zinc metalloprotease TK34_05915 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) TK34_05920 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) TK34_05925 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TK34_05940 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TK34_05945 ENOG4105C0B DNA polymerase III (alpha subunit) TK34_05950 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) TK34_05955 ENOG4108M3R transcriptional activator CadC TK34_05960 ENOG4105D5Q Arginine ornithine antiporter TK34_05965 ENOG4105CXN decarboxylase TK34_05970 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) TK34_05980 ENOG4105EQ2 LysR family Transcriptional regulator TK34_05985 ENOG4105C44 Serine transporter TK34_06000 ENOG4105EXG Transcriptional regulator TK34_06005 ENOG4105DVH amino acid TK34_06010 ENOG4105KNA -acetyltransferase TK34_06015 ENOG4105C5H ABC transporter TK34_06025 ENOG4105C9K Endothelin-converting enzyme 1 TK34_06030 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TK34_06035 ENOG4105BZU Histidine kinase TK34_06070 ENOG4107T9C Alpha amylase catalytic region TK34_06100 ENOG4105DIT ErfK YbiS YcfS YnhG family protein TK34_06105 ENOG4105EAQ (twin-arginine translocation) pathway signal TK34_06115 ENOG4105EN6 Membrane TK34_06120 ENOG4105EXN Sulfate transport protein CysZ TK34_06125 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TK34_06135 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TK34_06145 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase TK34_06150 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) TK34_06180 ENOG4105J12 Multidrug resistance protein mdtN TK34_06185 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) TK34_06195 ENOG4107R1I NAD-dependent malic enzyme TK34_06200 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TK34_06205 ENOG4106YYS transcriptional regulatory protein TK34_06210 ENOG4108IPJ Membrane TK34_06220 ENOG4105C26 Dehydrogenase TK34_06225 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family TK34_06230 ENOG4105C1G acyl-Coa dehydrogenase TK34_06235 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F TK34_06240 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase TK34_06245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TK34_06250 ENOG4105BZU Histidine kinase TK34_06260 ENOG4105ERG peptidase m48, ste24p TK34_06275 ENOG4106N3A copper homeostasis protein cutc TK34_06280 ENOG4108V1T peptidylprolyl cis-trans isomerase TK34_06285 ENOG4105CJ1 ABC, transporter TK34_06305 ENOG4105EZ7 amino acid ABC transporter TK34_06310 ENOG4105DRP amino acid AbC transporter TK34_06315 ENOG4105CDA abc transporter atp-binding protein TK34_06325 ENOG4105PTV Nudix Hydrolase TK34_06350 ENOG4105BZG amino acid carrier protein TK34_06355 ENOG4108KMH lipoate-protein ligase a TK34_06360 ENOG4105C2W permease TK34_06365 ENOG4105BZU Histidine kinase TK34_06370 ENOG4105RKX Protein of unknown function (DUF2498) TK34_06375 ENOG4105UQX Mate efflux family protein TK34_06380 ENOG4105ECQ AraC Family Transcriptional Regulator TK34_06385 ENOG4107R1I NAD-dependent malic enzyme TK34_06390 ENOG4105UYK outer membrane protein a TK34_06395 ENOG4105UYK outer membrane protein a TK34_06400 ENOG4105UYK outer membrane protein a TK34_06415 ENOG4105C8J )-transporter TK34_06420 ENOG4105D78 K07001 NTE family protein TK34_06425 ENOG4105BZU Histidine kinase TK34_06430 ENOG4105ENT Efflux transporter rnd family, mfp subunit TK34_06435 ENOG4105BZS acriflavin resistance protein TK34_06445 ENOG4105CCT upf0313 protein TK34_06475 ENOG4105EP9 oxidoreductase TK34_06485 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TK34_06490 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) TK34_06495 ENOG4105E4C Lytic transglycosylase catalytic TK34_06525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TK34_06535 ENOG4105CIY formyltetrahydrofolate deformylase TK34_06540 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) TK34_06550 ENOG4107QR8 Thioredoxin TK34_06560 ENOG4107TT5 NLP P60 protein TK34_06565 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) TK34_06585 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein TK34_06595 ENOG4108ZXH Ferredoxin TK34_06605 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TK34_06625 ENOG4105CBN LysR family transcriptional regulator TK34_06630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TK34_06635 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit TK34_06645 ENOG4107SSZ Phosphatase TK34_06650 ENOG4105EGS Mechanosensitive ion channel TK34_06655 ENOG4105CA9 Pyruvate kinase TK34_06670 ENOG4105CKD glutathione-regulated potassium-efflux system protein TK34_06680 ENOG4105DH7 May be involved in recombination (By similarity) TK34_06690 ENOG4107RH8 nuclease SbcCD subunit D TK34_06695 ENOG4105EYH Exonuclease TK34_06700 ENOG4105EYH Exonuclease TK34_06710 ENOG4105CPW cytochrome b561 TK34_06720 ENOG4105BZU Histidine kinase TK34_06725 ENOG4105C5Y PTS System TK34_06735 ENOG4105KZ7 phosphocarrier protein hpr TK34_06740 ENOG4105C6T cysteine synthase TK34_06745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TK34_06760 ENOG4108R96 Methyltransferase, YaeB family TK34_06780 ENOG4108JJ8 (ABC) transporter TK34_06785 ENOG4108JJ9 ABC, transporter TK34_06800 ENOG41065U4 response regulator TK34_06810 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) TK34_06825 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) TK34_06850 ENOG4105DZR Type I site-specific deoxyribonuclease TK34_06905 ENOG4105D70 Integrase catalytic subunit TK34_06910 ENOG4105F5W AtP-binding protein TK34_06920 ENOG4106FVC RNA methyltransferase TK34_06930 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) TK34_06935 ENOG4105D98 threonine synthase TK34_06945 ENOG4105C5H ABC transporter TK34_06965 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type TK34_06980 ENOG4105BZU Histidine kinase TK34_06985 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b TK34_06990 ENOG4108V1T peptidylprolyl cis-trans isomerase TK34_07005 ENOG4105CUB amino acid TK34_07020 ENOG4105CUB amino acid TK34_07025 ENOG4108JPW Aminotransferase TK34_07030 ENOG4105C26 Dehydrogenase TK34_07035 ENOG4107VRI Transcriptional regulator TK34_07040 ENOG4105CJP fad dependent oxidoreductase TK34_07055 ENOG4108YX2 DNA-binding protein TK34_07060 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TK34_07065 ENOG4105Q26 Siderophore-interacting protein TK34_07070 ENOG4105ENJ RND efflux system, outer membrane lipoprotein TK34_07075 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TK34_07080 ENOG4105DJY efflux transporter, rnd family, mfp subunit TK34_07090 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase TK34_07095 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TK34_07100 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TK34_07105 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TK34_07110 ENOG4105CFG Acts as a chaperone (By similarity) TK34_07115 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TK34_07125 ENOG4105D7K pfkb domain protein TK34_07140 ENOG4105WBN Transcriptional regulator (LacI family TK34_07160 ENOG41080HT Transcriptional regulator, arsr family TK34_07185 ENOG4105BZU Histidine kinase TK34_07190 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) TK34_07210 ENOG4108IJF Heavy metal efflux pump, CzcA TK34_07215 ENOG4105EP1 Efflux transporter rnd family, mfp subunit TK34_07235 ENOG4105CGK Exodeoxyribonuclease III TK34_07250 ENOG4105E5W Transporter TK34_07295 ENOG4105E2S oxidase) subunit II TK34_07300 ENOG4105BZ9 Cytochrome C oxidase, subunit I TK34_07305 ENOG4105CCU oxidase (Subunit III) TK34_07310 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) TK34_07315 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) TK34_07320 ENOG4107RDB Major Facilitator TK34_07330 ENOG4105KAF membrAne TK34_07345 ENOG4105D9N nucleoside TK34_07365 ENOG4105S2T inner membrane protein YbcI TK34_07375 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) TK34_07380 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) TK34_07385 ENOG4105DK0 Indole-3-glycerol phosphate synthase TK34_07390 ENOG4108I0Q anthranilate phosphoribosyltransferase TK34_07395 ENOG4108EFP Anthranilate synthase component II TK34_07400 ENOG4105CRQ synthase (Component I) TK34_07405 ENOG4105DB7 PHP domain protein TK34_07410 ENOG4107RTD sua5 ycio yrdc ywlc family protein TK34_07420 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) TK34_07425 ENOG4105FE9 pseudouridine synthase TK34_07430 ENOG4105C29 acyl-CoA thioesterase TK34_07450 ENOG4108IG5 Transcriptional regulator TK34_07455 ENOG4105C1P efflux transporter, rnd family, mfp subunit TK34_07460 ENOG4105BZS acriflavin resistance protein TK34_07465 ENOG4107QQG Dehydrogenase TK34_07470 ENOG4105J5G Transferase hexapeptide repeat containing protein TK34_07475 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TK34_07495 ENOG4105D3Q Sugar transferase TK34_07505 ENOG4105C1B dTDP-glucose 4-6-dehydratase TK34_07510 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase TK34_07515 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) TK34_07540 ENOG4108YXG UPF0502 protein TK34_07550 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) TK34_07565 ENOG4107RUY (E1 component), alpha subunit TK34_07570 ENOG4105CPP Dehydrogenase, E1 component TK34_07575 ENOG4107QSN dihydrolipoamide acetyltransferase TK34_07580 ENOG4105VEQ Cold shock protein TK34_07610 ENOG4108594 Permease of the drug metabolite transporter TK34_07615 ENOG4105N2W Transcriptional regulator TK34_07620 ENOG4105C6N Formate acetyltransferase TK34_07625 ENOG4105F1A Pyruvate formate-lyase TK34_07630 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TK34_07640 ENOG4105CPI Metal Dependent Phosphohydrolase TK34_07645 ENOG4105I08 Pseudouridine synthase TK34_07655 ENOG4107QSI ABC, transporter TK34_07660 ENOG4108RE9 Phosphodiesterase TK34_07675 ENOG4107ESN Flagella basal body P-ring formation protein flgA TK34_07680 ENOG4107R88 Chemotaxis protein (CheV) TK34_07685 ENOG4105BZU Histidine kinase TK34_07690 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TK34_07695 ENOG4108ZC9 flagellar basal-body rod protein flgc TK34_07705 ENOG4105BZE flagellar hook protein, FlgE TK34_07720 ENOG4108KPB Flagellar basal-body rod protein FlgF TK34_07725 ENOG4105CGA flagellar basal-body rod protein FlgG TK34_07730 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) TK34_07735 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) TK34_07740 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj TK34_07745 ENOG4105E1Q flagellar hook-associated protein TK34_07750 ENOG4105DTJ flagellar hook-associated protein TK34_07755 ENOG4105CJW magnesium transporter TK34_07760 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_07765 ENOG4107QPN acyl-Coa dehydrogenase TK34_07770 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) TK34_07775 ENOG4105E7A Glutamine amidotransferase TK34_07785 ENOG4105CHW UPF0052 protein TK34_07795 ENOG4105BZU Histidine kinase TK34_07805 ENOG4105WH1 Two component transcriptional regulator luxr family TK34_07810 ENOG4105BZU Histidine kinase TK34_07815 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TK34_07820 ENOG4108ZNS ferredoxin-type protein NapF TK34_07830 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TK34_07835 ENOG4108BGM Quinol dehydrogenase periplasmic component TK34_07840 ENOG4105GXZ Ferredoxin-type protein NapH TK34_07850 ENOG4105CUW cytochrome C-TYPE protein TK34_07855 ENOG4108RIR Molybdenum cofactor biosynthesis protein TK34_07860 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TK34_07865 ENOG4105M00 molybdopterin converting factor, subunit 1 TK34_07870 ENOG4108ZAF Molybdopterin TK34_07875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein TK34_07880 ENOG4105E0C molybdate abc transporter TK34_07885 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) TK34_07890 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) TK34_07905 ENOG4105QYK bacteriophage lambda Bor protein homolog TK34_07910 ENOG4105QYK bacteriophage lambda Bor protein homolog TK34_07915 ENOG4105D7A ATP-binding protein TK34_07930 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 TK34_07935 ENOG4105BZ1 (ABC) transporter TK34_07940 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) TK34_07945 ENOG4105W49 UPF0434 protein TK34_07950 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) TK34_07955 ENOG4105WH1 Two component transcriptional regulator luxr family TK34_07960 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TK34_07985 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system TK34_08020 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit TK34_08025 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein TK34_08030 ENOG4105DVI reductase, NrfD TK34_08035 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) TK34_08045 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) TK34_08050 ENOG4105C8N cysteinyl-tRNA synthetase TK34_08070 ENOG410620I Diguanylate cyclase TK34_08105 ENOG4108ZJT translation initiation factor, Sui1 TK34_08130 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TK34_08135 ENOG4105CZX twitching motility protein TK34_08145 ENOG4105BZU Histidine kinase TK34_08150 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) TK34_08155 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) TK34_08165 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TK34_08175 ENOG4108JQ1 Dehydrogenase TK34_08180 ENOG4105E66 phosphoriboisomerase A TK34_08185 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase TK34_08195 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) TK34_08200 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain TK34_08205 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain TK34_08210 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) TK34_08215 ENOG4107QS8 (LipO)protein TK34_08240 ENOG4108MK9 spermidine N(1)-acetyltransferase TK34_08245 ENOG4105C1J atp-dependent rna helicase TK34_08270 ENOG4108Z4X TRANSCRIPTIONal TK34_08285 ENOG4105EAB amino acid AbC transporter TK34_08290 ENOG4105DRP amino acid AbC transporter TK34_08295 ENOG4105CDA abc transporter atp-binding protein TK34_08300 ENOG4105BZ8 glutamate synthase TK34_08305 ENOG4105CBC glutamate synthase TK34_08310 ENOG4105N5T Radical SAM Protein TK34_08325 ENOG4105BZ1 (ABC) transporter TK34_08330 ENOG4105C42 Type I secretion membrane fusion protein (HlyD TK34_08375 ENOG4105C85 amino acid TK34_08390 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TK34_08440 ENOG4105D01 (LipO)protein TK34_08445 ENOG4105EYK Phosphatidylglycerophosphatase B TK34_08450 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) TK34_08455 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TK34_08465 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TK34_08470 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) TK34_08475 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase TK34_08480 ENOG4108S3P Sporulation domain protein TK34_08485 ENOG4108Z0T Part of a sulfur-relay system (By similarity) TK34_08490 ENOG4105EM2 membrane TK34_08495 ENOG4108MN8 Membrane TK34_08605 ENOG4106V6P Exoenzyme S synthesis protein C TK34_08620 ENOG4108KB1 transcriptional regulator, arac family TK34_08650 ENOG41066XE Type III export protein TK34_08655 ENOG41070MY type iii secretion TK34_08695 ENOG4105DIJ Phosphoethanolamine transferase TK34_08705 ENOG4105FF5 Membrane TK34_08715 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor TK34_08720 ENOG410620I Diguanylate cyclase TK34_08725 ENOG4108W1A pseudouridine synthase TK34_08735 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase TK34_08740 ENOG4105F1J Homogentisate 1,2-dioxygenase TK34_08750 ENOG4108RXX maleylacetoacetate isomerase TK34_08755 ENOG4108TGY Glutathione S-transferase TK34_08765 ENOG4105CAQ asparagine synthetase TK34_08775 ENOG4105CKD glutathione-regulated potassium-efflux system protein TK34_08780 ENOG4105D4U had-superfamily hydrolase, subfamily iia TK34_08785 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TK34_08790 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TK34_08795 ENOG4105EE5 Membrane protein terC TK34_08805 ENOG4105CQB FAD linked oxidase domain protein TK34_08815 ENOG4105KA0 thioesterase Superfamily protein TK34_08825 ENOG4105D3Y Na H antiporter TK34_08830 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) TK34_08840 ENOG4105EIY sodium-type flagellar protein motY TK34_08845 ENOG4108UYE Lactoylglutathione lyase TK34_08850 ENOG4105CSM endonuclease III TK34_08855 ENOG4105DZB Electron transport complex TK34_08865 ENOG4105D6A Electron transport complex TK34_08875 ENOG4108R3D Electron transport complex TK34_08880 ENOG4105DGN Electron transport complex TK34_08885 ENOG4108PCN EamA-like transporter family TK34_08895 ENOG4107SDU Methyl-accepting chemotaxis TK34_08900 ENOG4105RKW reductase (By TK34_08905 ENOG4105CSX c4-dicarboxylate anaerobic carrier TK34_08910 ENOG4105CHM Aminotransferase TK34_08920 ENOG41090BQ Glutaredoxin TK34_08925 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase TK34_08930 ENOG4105CFI type iii restriction protein res subunit TK34_08935 ENOG4105EFX secretion protein, HlyD family TK34_08940 ENOG4105KK7 inner membrane protein YiaW TK34_08950 ENOG4108NEV two component transcriptional regulator, LytTR family TK34_08955 ENOG4108HRK Histidine kinase TK34_08960 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_08965 ENOG4108EKI Dehydrogenase TK34_08975 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein TK34_08980 ENOG4107QSI ABC, transporter TK34_08985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TK34_08990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TK34_08995 ENOG4105C3U ABC transporter TK34_09000 ENOG4108JQ7 (ABC) transporter TK34_09005 ENOG4105DU1 integral membrane protein, terc TK34_09010 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TK34_09020 ENOG4105CK2 sodium dicarboxylate symporter TK34_09035 ENOG4105CD3 dihydroorotase TK34_09045 ENOG4108NVR Methyl-accepting chemotaxis TK34_09050 ENOG4105K59 histidine triad (HIT) protein TK34_09085 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TK34_09090 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TK34_09100 ENOG4105CKW Inner membrane protein yedI TK34_09105 ENOG4105DPN Oligoendopeptidase f TK34_09110 ENOG4105DPN Oligoendopeptidase f TK34_09115 ENOG4105C2W permease TK34_09125 ENOG4105CEP NADH dehydrogenase TK34_09145 ENOG4105K8R UPF0145 protein TK34_09155 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A TK34_09160 ENOG4107T7U Sulfatase TK34_09170 ENOG4105CFH Aspartokinase TK34_09175 ENOG4107QZM n-acetylglutamate synthase TK34_09180 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TK34_09205 ENOG4105F2Z 3-oxoadipate enol-lactonase TK34_09210 ENOG4108UYE Lactoylglutathione lyase TK34_09220 ENOG4105CR8 Transcriptional regulator TK34_09225 ENOG4105DAA L-lactate TK34_09235 ENOG4107QR9 Iron-sulfur cluster binding protein TK34_09240 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) TK34_09270 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TK34_09280 ENOG4105C2C drug resistance transporter, Bcr CflA TK34_09330 ENOG4105C2M dna polymerase I TK34_09345 ENOG4105YB8 TM2 domain containing protein TK34_09395 ENOG4105CHH sulfate transporter TK34_09420 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TK34_09425 ENOG4105C8Q Methyl-accepting chemotaxis TK34_09430 ENOG4105BZU Histidine kinase TK34_09435 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TK34_09440 ENOG4105BZU Histidine kinase TK34_09445 ENOG4108V3W Chemotaxis protein, CheW TK34_09450 ENOG4105C8Q Methyl-accepting chemotaxis TK34_09455 ENOG4105CBS Chea signal transduction histidine kinase TK34_09465 ENOG4108VYJ response regulator receiver protein TK34_09470 ENOG4105E3S small subunit TK34_09480 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit TK34_09485 ENOG4105DPX Hydrogenase, large subunit TK34_09490 ENOG4108USZ hydrogenase TK34_09495 ENOG4108WGS hydrogenase 2-specific chaperone TK34_09505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TK34_09510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TK34_09515 ENOG4105C3U ABC transporter TK34_09520 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TK34_09525 ENOG4107RSS Hydrogenase accessory protein HypB TK34_09530 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) TK34_09535 ENOG4105C45 hydrogenase expression formation protein (HypE) TK34_09540 ENOG4105CQS hydrogenase expression formation protein HypD TK34_09545 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF TK34_09555 ENOG4105EM7 Selenocysteine-specific translation elongation factor TK34_09560 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) TK34_09565 ENOG4108MG9 hydrogenase 3 maturation protease TK34_09570 ENOG4105I6X formate hydrogenlyase maturation TK34_09575 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit TK34_09585 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_09590 ENOG4107TDF Formate hydrogenlyase subunit 4 TK34_09595 ENOG4108JPZ Monovalent cation H antiporter subunit D TK34_09600 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) TK34_09605 ENOG4105DFH Transport of potassium into the cell (By similarity) TK34_09620 ENOG4108RC0 Electron transport protein TK34_09625 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TK34_09630 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TK34_09645 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TK34_09650 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TK34_09655 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) TK34_09660 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TK34_09665 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) TK34_09670 ENOG4105WJG Glutathione TK34_09675 ENOG4107RE1 Inosine-guanosine kinase TK34_09690 ENOG4105BZU Histidine kinase TK34_09695 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TK34_09705 ENOG4105F3T (LipO)protein TK34_09715 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase TK34_09720 ENOG4105WQI isochorismatase TK34_09725 ENOG4105CEY Amp-dependent synthetase and ligase TK34_09730 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase TK34_09740 ENOG4105CEY Amp-dependent synthetase and ligase TK34_09745 ENOG4108MES Periplasmic binding protein TK34_09750 ENOG4108TSE Transferase TK34_09755 ENOG4105E0A ABC, transporter TK34_09760 ENOG4105TVJ transport system, permease TK34_09765 ENOG4105DQ5 transport system permease protein TK34_09770 ENOG4105D05 Receptor TK34_09785 ENOG4105QZU Inner membrane protein YfeZ TK34_09790 ENOG4107QUT magnesium and cobalt transport protein CorA TK34_09795 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase TK34_09800 ENOG4105BZJ Electron transfer flavoprotein TK34_09805 ENOG4105C10 Electron transfer flavoprotein TK34_09810 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) TK34_09815 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TK34_09820 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TK34_09825 ENOG4108NVR Methyl-accepting chemotaxis TK34_09830 ENOG4105D4P Coproporphyrinogen iii oxidase TK34_09835 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TK34_09860 ENOG4105DFH Transport of potassium into the cell (By similarity) TK34_09865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TK34_09870 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TK34_09880 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TK34_09895 ENOG4105FQ6 thiopurine methyltransferase TK34_09900 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF TK34_09905 ENOG4108BY2 phosphohistidine phosphatase TK34_09915 ENOG4108IPJ Membrane TK34_09930 ENOG4108J59 Extracellular solute-binding protein, family 5 TK34_09935 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 TK34_09940 ENOG4108JA2 transcriptioN-repair coupling factor TK34_09950 ENOG4105D60 lipoprotein releasing system transmembrane protein TK34_09955 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TK34_09960 ENOG4105D60 lipoprotein releasing system transmembrane protein TK34_09975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TK34_09980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TK34_09985 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TK34_09990 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) TK34_10000 ENOG4105EIN peptidylprolyl cis-trans isomerase TK34_10005 ENOG4105C5H ABC transporter TK34_10010 ENOG4107QN1 sodium solute TK34_10015 ENOG41062QD Membrane TK34_10030 ENOG41060WC Enoyl-CoA hydratase TK34_10060 ENOG4105BZG amino acid carrier protein TK34_10075 ENOG4106HK8 GPR1 FUN34 yaaH family protein TK34_10110 ENOG4107QX3 carboxylase TK34_10115 ENOG4105C1G acyl-Coa dehydrogenase TK34_10120 ENOG4105C26 Dehydrogenase TK34_10125 ENOG4105C1G acyl-Coa dehydrogenase TK34_10130 ENOG4105E39 Enoyl-CoA hydratase TK34_10135 ENOG4105E39 Enoyl-CoA hydratase TK34_10140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TK34_10150 ENOG4105D5Q Arginine ornithine antiporter TK34_10155 ENOG4105HF0 Membrane TK34_10160 ENOG4105BZU Histidine kinase TK34_10165 ENOG4108KB2 LysR family Transcriptional regulator TK34_10170 ENOG4105CS2 ec 3.2.1.21 TK34_10175 ENOG4105BZU Histidine kinase TK34_10185 ENOG4105DHT Metal Dependent Phosphohydrolase TK34_10190 ENOG4105CHR reductase TK34_10195 ENOG4105CBN LysR family transcriptional regulator TK34_10200 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) TK34_10210 ENOG4105DUM transcriptional regulator, lysR family TK34_10220 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase TK34_10225 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase TK34_10250 ENOG4105CQ2 DNA polymerase TK34_10285 ENOG4105W1I UPF0253 protein TK34_10290 ENOG4108R6K riboflavin synthase, subunit alpha TK34_10305 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 TK34_10310 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR TK34_10315 ENOG4108SXK Transporter Drug Metabolite Exporter family TK34_10320 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TK34_10355 ENOG4105XW2 UPF0263 protein TK34_10360 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase TK34_10370 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) TK34_10375 ENOG4107QMS site-determining protein TK34_10380 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) TK34_10385 ENOG4105VNG YcgL domain-containing protein TK34_10390 ENOG4105CVE Lytic murein transglycosylase TK34_10395 ENOG4105EJQ L-serine dehydratase TK34_10400 ENOG4105EJQ L-serine dehydratase TK34_10405 ENOG4105NBK UPF0345 protein TK34_10420 ENOG4105CHU acetyl-coa acetyltransferase TK34_10425 ENOG4105D58 Diguanylate phosphodiesterase TK34_10430 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation TK34_10455 ENOG4105EMN RNA polymerase sigma factor TK34_10485 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TK34_10490 ENOG4105CHU acetyl-coa acetyltransferase TK34_10495 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TK34_10500 ENOG4108VWS Yaeq family TK34_10510 ENOG4108JUB Transcriptional regulator TK34_10515 ENOG4105IW6 Carbamoyltransferase TK34_10520 ENOG4107RCH Diaminopropionate ammonia-lyase TK34_10525 ENOG4107S4Y M20 DapE family protein YgeY TK34_10535 ENOG4105C5B carbamate kinase TK34_10540 ENOG4108Q5Y Membrane TK34_10545 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family TK34_10550 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC TK34_10560 ENOG4105BZ8 glutamate synthase TK34_10565 ENOG4107UUR Chlorohydrolase aminohydrolase TK34_10570 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase TK34_10575 ENOG4105C7W Xanthine dehydrogenase TK34_10580 ENOG4105C2W permease TK34_10585 ENOG4107QUY Guanine deaminase TK34_10590 ENOG4105C7N Xanthine uracil vitamin C permease TK34_10595 ENOG4105C7W Xanthine dehydrogenase TK34_10600 ENOG4108HR6 Dehydrogenase TK34_10605 ENOG4108UTP (2Fe-2S)-binding domain protein TK34_10615 ENOG4107MBR 17 kDa surface antigen TK34_10625 ENOG4105CSX c4-dicarboxylate anaerobic carrier TK34_10630 ENOG4105CEY Amp-dependent synthetase and ligase TK34_10645 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase TK34_10650 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) TK34_10655 ENOG4105BZU Histidine kinase TK34_10665 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_10670 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase TK34_10675 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) TK34_10685 ENOG4105CIH Imidazole acetol-phosphate transaminase TK34_10690 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) TK34_10695 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) TK34_10705 ENOG4105DVT helicase TK34_10710 ENOG41072GX Peptidase M22 Glycoprotease TK34_10720 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TK34_10725 ENOG4105CEY Amp-dependent synthetase and ligase TK34_10730 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) TK34_10735 ENOG4106PMH Extracellular solute-binding protein family 3 TK34_10745 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) TK34_10750 ENOG4105WD1 Membrane TK34_10755 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TK34_10760 ENOG4107QMP dna polymerase iii subunits gamma and tau TK34_10765 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TK34_10770 ENOG4105DWD nucleoside recognition domain protein TK34_10790 ENOG4105CQ7 ATP-dependent helicase TK34_10795 ENOG4105CHH sulfate transporter TK34_10830 ENOG4105BZU Histidine kinase TK34_10835 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_10840 ENOG4105C5X domain protein TK34_10845 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) TK34_10850 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) TK34_10855 ENOG4105FAT Acyl-transferase TK34_10865 ENOG4105DR4 Methyltransferase TK34_10870 ENOG4108NVR Methyl-accepting chemotaxis TK34_10875 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 TK34_10880 ENOG4108K3A Glutathione S-transferase TK34_10885 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TK34_10890 ENOG4105D1F ATP-binding protein TK34_10895 ENOG4105DBI uridine monophosphokinase TK34_10900 ENOG4105DHP deoxycytidine triphosphate deaminase TK34_10905 ENOG4105CJ3 phosphate transporter TK34_10910 ENOG4105C03 ribonuclease TK34_10915 ENOG4105EI2 Pseudouridine synthase TK34_10920 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TK34_10925 ENOG4108UHJ MAF-like protein TK34_10930 ENOG4105CNH Multidrug resistance protein MdtL TK34_10945 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein TK34_10950 ENOG4105VGS 50s ribosomal protein l32 TK34_10955 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) TK34_10960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TK34_10965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TK34_10970 ENOG4105CHR reductase TK34_10975 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TK34_10980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TK34_10985 ENOG4105YAZ 4-amino-4-deoxychorismate lyase TK34_10990 ENOG4105HHA aminodeoxychorismate lyase TK34_10995 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TK34_11000 ENOG4107QRG dna polymerase iii TK34_11005 ENOG4105F8V Hydrolase, tatD family TK34_11020 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TK34_11025 ENOG4105DY2 Paraquat-inducible protein b TK34_11030 ENOG4105F1S paraquat-inducible protein a TK34_11040 ENOG4105CR4 methylisocitrate lyase TK34_11045 ENOG4105BZN citrate synthase TK34_11050 ENOG4105DXD 2-methylcitrate dehydratase TK34_11090 ENOG4105PDP Short chain dehydrogenase TK34_11100 ENOG4105X2V dna damage-inducible protein TK34_11125 ENOG4105MQ5 zona occludens toxin TK34_11165 ENOG4105DAN ATP-dependent protease TK34_11170 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) TK34_11180 ENOG4105C5H ABC transporter TK34_11190 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TK34_11195 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) TK34_11200 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) TK34_11205 ENOG4105C7I Dehydrogenase TK34_11215 ENOG4105CD8 aminopeptidase N TK34_11220 ENOG4105CN1 protease TK34_11225 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) TK34_11230 ENOG4108ZGC gaf domain protein TK34_11240 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i TK34_11255 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) TK34_11280 ENOG4105DS0 Transcriptional regulator, Crp Fnr family TK34_11285 ENOG4105Q9Y Universal stress protein TK34_11290 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) TK34_11305 ENOG4108RXX maleylacetoacetate isomerase TK34_11310 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) TK34_11315 ENOG4105C2J ABC transporter TK34_11320 ENOG4105CNN ABC, transporter TK34_11325 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TK34_11330 ENOG4108RVA ribokinase TK34_11335 ENOG4105ETE Transcriptional regulator (LacI family TK34_11340 ENOG4108KHX Diguanylate cyclase TK34_11350 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TK34_11365 ENOG4105BZU Histidine kinase TK34_11370 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) TK34_11375 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) TK34_11380 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TK34_11385 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TK34_11390 ENOG41083UC 50s ribosomal protein L35 TK34_11395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TK34_11400 ENOG4105C22 threonyL-tRNA synthetase TK34_11415 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TK34_11420 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TK34_11425 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TK34_11430 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TK34_11435 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TK34_11440 ENOG4105XPH Ferredoxin TK34_11445 ENOG4105CA3 membrane-bound lytic murein transglycosylase TK34_11450 ENOG4105XZD Fe-S protein TK34_11455 ENOG4107SZR mannose-6-phosphate isomerase TK34_11460 ENOG4105F3R pts system mannose fructose sorbose family iid TK34_11465 ENOG4105ETZ PTS System TK34_11470 ENOG4108EQA pts system TK34_11485 ENOG4107P2S Transcriptional regulator TK34_11490 ENOG4108Y83 glucose-6-phosphate isomerase TK34_11495 ENOG4105DM4 PTS System TK34_11500 ENOG4105DE4 1-phosphofructokinase TK34_11505 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein TK34_11510 ENOG4107B7Y DNA-binding transcriptional regulator FruR TK34_11515 ENOG4105E0U tyrosine-specific transport protein TK34_11530 ENOG4105C1J atp-dependent rna helicase TK34_11540 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TK34_11545 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) TK34_11550 ENOG4108DG9 Smr protein MutS2 TK34_11570 ENOG4105BZU Histidine kinase TK34_11575 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TK34_11600 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA TK34_11640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TK34_11660 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) TK34_11665 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) TK34_11670 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) TK34_11675 ENOG4106371 Methyltransferase TK34_11680 ENOG4107S90 membrAne TK34_11690 ENOG4105CTQ phosphohexokinase TK34_11695 ENOG4105CH2 amidohydrolase TK34_11700 ENOG4105PAD Hydrolase TK34_11705 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TK34_11760 ENOG4105CPB ATP-dependent endonuclease of the OLD family TK34_11780 ENOG4105EJ9 Membrane TK34_11785 ENOG4106IUH DTW domain containing protein TK34_11795 ENOG4105CPF Cell wall formation (By similarity) TK34_11810 ENOG4105C1J atp-dependent rna helicase TK34_11815 ENOG4105K5X acetyltransferase TK34_11825 ENOG4105KK4 UPF0060 membrane protein TK34_11855 ENOG41061CK Antibiotic biosynthesis monooxygenase TK34_11860 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) TK34_11880 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class TK34_11890 ENOG4105WQ3 Rna-binding protein TK34_11900 ENOG4105BZ1 (ABC) transporter TK34_11905 ENOG4105BZ1 (ABC) transporter TK34_11910 ENOG4105BZU Histidine kinase TK34_11915 ENOG4105K63 Thioredoxin TK34_11920 ENOG4105C8P )-transporter TK34_11930 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) TK34_11960 ENOG4105C44 Serine transporter TK34_11965 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) TK34_11970 ENOG4105C9U ATP-dependent DNA helicase RecQ TK34_11975 ENOG4105CYN Serine protein kinase TK34_11980 ENOG4106AKX UPF0229 protein TK34_11985 ENOG4105ED1 spovr family TK34_11990 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) TK34_11995 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) TK34_12000 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) TK34_12005 ENOG4105DQR SNARE associated Golgi TK34_12015 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TK34_12025 ENOG4105D0C transport protein TK34_12030 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) TK34_12050 ENOG4108MRH transcriptional regulatory protein TK34_12055 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TK34_12060 ENOG4105E2R ROK family TK34_12065 ENOG4105C8Q Methyl-accepting chemotaxis TK34_12070 ENOG4105K5B UPF0225 protein TK34_12075 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A TK34_12080 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B TK34_12085 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) TK34_12105 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit TK34_12110 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein TK34_12115 ENOG4105DVI reductase, NrfD TK34_12120 ENOG4105DA4 cytochrome c-type biogenesis protein TK34_12125 ENOG4107QX9 Thiol disulfide interChange protein TK34_12130 ENOG4108DMF Cytochrome C biogenesis protein TK34_12135 ENOG4108Z4K mutator MutT protein TK34_12140 ENOG41061WM D-Alanyl-D-Alanine TK34_12145 ENOG4105C0F tryptophanase EC 4.1.99.1 TK34_12150 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein TK34_12155 ENOG4105MWK D-amino acid dehydrogenase, small subunit TK34_12170 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TK34_12185 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) TK34_12190 ENOG4105DZ2 Transcriptional regulator TK34_12200 ENOG4105E0K tonB-dependent siderophore receptor TK34_12205 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF TK34_12215 ENOG4105CR8 Transcriptional regulator TK34_12220 ENOG4108RYK Nad-dependent epimerase dehydratase TK34_12240 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TK34_12245 ENOG4105KPY Small multidrug resistance protein TK34_12250 ENOG4105DDY UPF0142 protein ycaO TK34_12255 ENOG4105TMB Formate nitrite transporter TK34_12260 ENOG4105C6N Formate acetyltransferase TK34_12265 ENOG4108KAZ Involved in phosphonate degradation (By similarity) TK34_12270 ENOG4108JPW Aminotransferase TK34_12275 ENOG4107STF Involved in phosphonate degradation (By similarity) TK34_12285 ENOG4105C4Y ABC transporter TK34_12295 ENOG4107RCV ABC transporter, permease TK34_12300 ENOG4105CJP fad dependent oxidoreductase TK34_12315 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha TK34_12320 ENOG4105CMV Succinyl-CoA synthetase subunit beta TK34_12325 ENOG4105C7S Dehydrogenase TK34_12330 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 TK34_12335 ENOG4105E33 succinate dehydrogenase TK34_12340 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) TK34_12345 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein TK34_12355 ENOG4105BZN citrate synthase TK34_12375 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TK34_12380 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) TK34_12390 ENOG4105CEE C4-dicarboxylate transporter TK34_12405 ENOG4108VKG metal-dependent hydrolase TK34_12420 ENOG4105NRA 50s ribosomal protein l31 type b TK34_12430 ENOG4105EUB pirin domain protein TK34_12435 ENOG4105HEI LysR family (Transcriptional regulator TK34_12445 ENOG4105CNN ABC, transporter TK34_12455 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator TK34_12460 ENOG4105EF1 ribulokinase TK34_12470 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) TK34_12475 ENOG4105CJB Exodeoxyribonuclease I TK34_12485 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 TK34_12495 ENOG41067MG lrgb family TK34_12500 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) TK34_12505 ENOG4108IQE Amp-dependent synthetase and ligase TK34_12510 ENOG4105MH2 YfcL protein TK34_12520 ENOG4105EE5 Membrane protein terC TK34_12525 ENOG41090EK ompa motb domain protein TK34_12530 ENOG4108KHX Diguanylate cyclase TK34_12535 ENOG4108WS1 TK34_12545 ENOG41090A4 Pterin carbinolamine dehydratase TK34_12550 ENOG41090A4 Pterin carbinolamine dehydratase TK34_12555 ENOG4105MIR Phenylalanine 4-monooxygenase TK34_12560 ENOG4106K28 UPF0283 membrane protein TK34_12565 ENOG4105CM6 amino acid regulated cytosolic protein TK34_12575 ENOG4105YYT phage shock protein B TK34_12580 ENOG41087YS Phage shock protein A TK34_12585 ENOG4105E51 psp operon transcriptional activator TK34_12590 ENOG4108J59 Extracellular solute-binding protein, family 5 TK34_12595 ENOG4108I5W peptide transport system, permease protein TK34_12600 ENOG4108EU3 peptide transport system, permease TK34_12605 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein TK34_12610 ENOG4108JQ2 peptide transport system atp-binding protein TK34_12615 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase TK34_12620 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase TK34_12625 ENOG4105E96 Colicin v production protein TK34_12630 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TK34_12635 ENOG4105D1H recombination factor protein RarA TK34_12640 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) TK34_12645 ENOG4105CNU cell division protein FtsK TK34_12650 ENOG4105EW9 transcriptional regulator AsnC family TK34_12655 ENOG4105C3M thioredoxin reductase TK34_12660 ENOG4105BZU Histidine kinase TK34_12665 ENOG4107MBR 17 kDa surface antigen TK34_12670 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) TK34_12675 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate TK34_12680 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) TK34_12685 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TK34_12690 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) TK34_12695 ENOG4105VEQ Cold shock protein TK34_12700 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TK34_12725 ENOG4105NVB glycoside hydrolase, family 19 TK34_12735 ENOG4105CS6 Rhs element vgr protein TK34_12770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TK34_12840 ENOG4105CS6 Rhs element vgr protein TK34_12845 ENOG4108WC9 type VI secretion system effector, hcp1 family TK34_12855 ENOG4108RMJ sensory transduction regulator TK34_12865 ENOG4107104 thymidine kinase TK34_12870 ENOG4107S6Z Na H antiporter TK34_12880 ENOG4108WBT adenosyltransferase TK34_12885 ENOG4105VRT cytoplasmic protein TK34_12890 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) TK34_12895 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) TK34_12910 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) TK34_12915 ENOG4105CFV Tetratricopeptide repeat protein TK34_12925 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) TK34_12930 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TK34_12935 ENOG4105CAT Cytidine monophosphate kinase TK34_12940 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) TK34_12945 ENOG4107R11 Transcriptional regulator TK34_12950 ENOG4105CMU LysR family (Transcriptional regulator TK34_12955 ENOG4105D2S major facilitator superfamily TK34_12970 ENOG4108DBC nitroreductase TK34_12975 ENOG4105BZU Histidine kinase TK34_12985 ENOG4105CBN LysR family transcriptional regulator TK34_12990 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_13015 ENOG4107RGM aldo keto reductase TK34_13020 ENOG4105VFU Rna-binding protein TK34_13030 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) TK34_13040 ENOG4105HA9 of methanol dehydrogenase type TK34_13065 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain TK34_13070 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_13075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_13080 ENOG4105GKE subunit e TK34_13085 ENOG4107QIZ NADH dehydrogenase TK34_13090 ENOG4108IEH NADH dehydrogenase subunit g TK34_13095 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) TK34_13100 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_13105 ENOG4107UFS subunit j TK34_13110 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_13115 ENOG4105D65 subunit l TK34_13120 ENOG4105C8S subunit m TK34_13125 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TK34_13135 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_13140 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_13145 ENOG4107QIK phosphoribosylformylglycinamidine synthase TK34_13150 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) TK34_13155 ENOG4105VPD cellular component movement TK34_13160 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TK34_13165 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) TK34_13175 ENOG4105CUT histidyl-tRNA synthetase TK34_13180 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TK34_13185 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) TK34_13195 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TK34_13200 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) TK34_13205 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TK34_13215 ENOG4108ZIT Ferredoxin, 2FE-2S TK34_13220 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB TK34_13225 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) TK34_13230 ENOG4108Z4V iron-sulfur cluster assembly TK34_13235 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins TK34_13240 ENOG4105C3J Cysteine desulfurase TK34_13250 ENOG4105CVS RNA methyltransferase TrmH family, group 1 TK34_13260 ENOG4105XPQ lipid carrier protein TK34_13265 ENOG4105CFP Peptidase U32 TK34_13270 ENOG4106RZ4 Peptidase U32 TK34_13285 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TK34_13290 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TK34_13295 ENOG4105VIE preprotein translocase, subunit YajC TK34_13300 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) TK34_13305 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) TK34_13310 ENOG4105W87 Cbs domain TK34_13315 ENOG4105D3R alkyl hydroperoxide reductase TK34_13325 ENOG4108ISG Major Facilitator TK34_13340 ENOG4105K89 arsenate reductase TK34_13345 ENOG4105D6J arsenicaL-resistance protein TK34_13455 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TK34_13460 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TK34_13465 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TK34_13470 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family TK34_13475 ENOG4105D0A hydroxylase TK34_13485 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) TK34_13500 ENOG4105E5M Multidrug resistance protein D TK34_13505 ENOG4105CYM Glutathione S-transferase TK34_13535 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TK34_13560 ENOG4105MQ3 flagellar protein FliS TK34_13575 ENOG4105I03 Flagellin TK34_13580 ENOG4105I03 Flagellin TK34_13585 ENOG4105EN6 Membrane TK34_13595 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) TK34_13605 ENOG4108JQB penicillin-binding protein 1C TK34_13610 ENOG4105DN3 alpha-2-macroglobulin domain protein TK34_13615 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TK34_13620 ENOG4105BZU Histidine kinase TK34_13625 ENOG4105F1A Pyruvate formate-lyase TK34_13645 ENOG4105DSP amino acid AbC transporter TK34_13650 ENOG4106PMH Extracellular solute-binding protein family 3 TK34_13655 ENOG4108JEH abc transporter atp-binding protein TK34_13660 ENOG4105DWU Membrane TK34_13665 ENOG4105DYB Isoaspartyl dipeptidase TK34_13670 ENOG4108ZYK Acyl carrier protein phosphodiesterase TK34_13685 ENOG4105K89 arsenate reductase TK34_13695 ENOG4105ERG peptidase m48, ste24p TK34_13700 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) TK34_13715 ENOG4105CSR polyphosphate kinase 2 TK34_13720 ENOG4108IJ9 (ABC) transporter TK34_13725 ENOG4105EG2 ABC transporter, permease TK34_13730 ENOG4105D56 permease protein TK34_13735 ENOG4107FKK extracellular solute-binding protein family 1 TK34_13740 ENOG4106V8H Nucleoid-associated protein TK34_13745 ENOG4105PAN UPF0352 protein TK34_13750 ENOG4105E68 Sulfatase TK34_13755 ENOG4105D05 Receptor TK34_13760 ENOG4105CUG Oligopeptidase b TK34_13780 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) TK34_13785 ENOG4108WFC UPF0438 protein yifE TK34_13790 ENOG4105CVI Transcriptional regulator TK34_13800 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TK34_13805 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase TK34_13810 ENOG4105C6V Glycerol-3-phosphate dehydrogenase TK34_13815 ENOG4105E98 transcriptional regulator DeoR family TK34_13820 ENOG4105CXY transporter TK34_13825 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) TK34_13830 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TK34_13835 ENOG4105HEI LysR family (Transcriptional regulator TK34_13855 ENOG4105CV8 reductase TK34_13860 ENOG4105F27 Major Facilitator TK34_13870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TK34_13875 ENOG4105C4M (Ubiquinol oxidase) subunit I TK34_13880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TK34_13890 ENOG4108Q2J Inner membrane protein YebE TK34_13910 ENOG4105D2S major facilitator superfamily TK34_13925 ENOG4105DJ2 Major Facilitator Superfamily TK34_13930 ENOG4105FE9 pseudouridine synthase TK34_13935 ENOG4105D82 Glutamate dehydrogenase TK34_13945 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) TK34_13955 ENOG4108R4U Hnh endonuclease TK34_13965 ENOG4105WWK YheO domain protein TK34_13970 ENOG4105CEM UPF0597 protein TK34_13975 ENOG4105KME endoribonuclease L-psp TK34_13980 ENOG4105C44 Serine transporter TK34_13985 ENOG4108NVR Methyl-accepting chemotaxis TK34_14000 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) TK34_14010 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TK34_14035 ENOG4108YYC ycei family TK34_14040 ENOG4105CC0 LysR family Transcriptional regulator TK34_14050 ENOG4105CKU formyltetrahydrofolate synthetase TK34_14055 ENOG4105C8Q Methyl-accepting chemotaxis TK34_14060 ENOG4105EUJ GTP cyclohydrolase i TK34_14065 ENOG4105CVM Molybdenum cofactor synthesis domain protein TK34_14070 ENOG4105D06 uba thif-type nad fad binding protein TK34_14075 ENOG4105CGF Aromatic amino acid aminotransferase TK34_14090 ENOG4105DVT helicase TK34_14100 ENOG4105DGU Histone deacetylase TK34_14105 ENOG4108ISG Major Facilitator TK34_14110 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) TK34_14140 ENOG4105NXH GreA GreB family elongation factor TK34_14145 ENOG4108KX4 response regulator TK34_14150 ENOG4105BZU Histidine kinase TK34_14155 ENOG4105CXY transporter TK34_14160 ENOG4105BZU Histidine kinase TK34_14165 ENOG4106TNF Periplasmic binding protein TK34_14170 ENOG4105E5Q amino acid AbC transporter TK34_14175 ENOG4105CDA abc transporter atp-binding protein TK34_14195 ENOG4105D5Q Arginine ornithine antiporter TK34_14200 ENOG4105C3R Methionine synthase TK34_14210 ENOG4105C37 (CBS) domain TK34_14220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TK34_14225 ENOG4105E2Z phosphate ABC transporter (Permease TK34_14230 ENOG4105C8U phosphate abc transporter TK34_14235 ENOG4108Z6B deaminase TK34_14245 ENOG4107QP3 malate synthase g TK34_14250 ENOG4108I9X Isocitrate lyase TK34_14265 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) TK34_14270 ENOG4105CXB phosphoribosylaminoimidazole synthetase TK34_14275 ENOG4108V3E phosphoribosylglycinamide formyltransferase TK34_14280 ENOG4107QNR UPF0135 protein TK34_14285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_14290 ENOG4105BZU Histidine kinase TK34_14295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_14305 ENOG4105RH4 Glycine cleavage system transcriptional repressor TK34_14310 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) TK34_14315 ENOG4105C9X ppx gppa phosphatase TK34_14325 ENOG4108JDX DNA polymerase iii, epsilon subunit TK34_14330 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TK34_14335 ENOG4105D1A Methyltransferase TK34_14340 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TK34_14345 ENOG4105E9H Lytic Murein transglycosylase TK34_14360 ENOG4105NAU thioesterase Superfamily protein TK34_14370 ENOG41060NJ transcriptional regulator TK34_14375 ENOG4107SC1 transglycosylase TK34_14380 ENOG4105BZU Histidine kinase TK34_14385 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA TK34_14405 ENOG4105MA0 exported protein TK34_14410 ENOG4105CFU surface antigen TK34_14420 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TK34_14435 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) TK34_14445 ENOG4105VNH ABC transporter solute-binding protein TK34_14455 ENOG4108VGW abc transporter atp-binding protein TK34_14460 ENOG4108T9J Cdp-alcohol phosphatidyltransferase TK34_14465 ENOG4105CVE Lytic murein transglycosylase TK34_14490 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 TK34_14495 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) TK34_14500 ENOG4105EV9 Alpha Beta Hydrolase TK34_14510 ENOG4105NNH LexA regulated protein TK34_14515 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) TK34_14525 ENOG41090R7 Ferric uptake TK34_14530 ENOG4105CX6 glutaminyL-tRNA synthetase TK34_14545 ENOG4105E2D ec 3.2.1.52 TK34_14550 ENOG4105CI1 PTS System TK34_14555 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TK34_14560 ENOG4105CE4 GlcNAc 6-P deacetylase TK34_14565 ENOG4105E2R ROK family TK34_14570 ENOG4105DIJ Phosphoethanolamine transferase TK34_14575 ENOG4105CDY transcriptional regulatory protein TK34_14580 ENOG4105C9M aspartyl-trna synthetase TK34_14585 ENOG41081XQ Conserved Protein TK34_14590 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) TK34_14595 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) TK34_14615 ENOG4105D3R alkyl hydroperoxide reductase TK34_14620 ENOG4105C5Q Transcriptional regulator TK34_14630 ENOG4107TT5 NLP P60 protein TK34_14640 ENOG4107RGH Aldehyde dehydrogenase TK34_14645 ENOG4107Z3H Transcriptional regulator, TetR family TK34_14665 ENOG4105C6T cysteine synthase TK34_14685 ENOG4105UQX Mate efflux family protein TK34_14705 ENOG4107SQI penicillin amidase TK34_14710 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TK34_14720 ENOG4105QVC MOSC domain-containing protein TK34_14720 ENOG4105QVC MOSC domain-containing protein TK34_14725 ENOG4107SDU Methyl-accepting chemotaxis TK34_14730 ENOG4105D0M Protease HtpX homolog TK34_14735 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) TK34_14740 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TK34_14745 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TK34_14750 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) TK34_14770 ENOG4105C5S asparaginyl-tRNA synthetase TK34_14775 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter TK34_14790 ENOG4105CEE C4-dicarboxylate transporter TK34_14805 ENOG4105KUZ arsenate reductase TK34_14810 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) TK34_14820 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) TK34_14830 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) TK34_14840 ENOG410829K Lysine exporter protein (Lyse ygga) TK34_14845 ENOG4108NVR Methyl-accepting chemotaxis TK34_14850 ENOG4105RX8 Protein of unknown function (DUF1523) TK34_14870 ENOG4105DU0 nucleoside hydrolase TK34_14875 ENOG4105D3G Pseudouridine synthase TK34_14880 ENOG4107SXA Phosphorylase TK34_14885 ENOG4105C0A alcohol dehydrogenase TK34_14965 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) TK34_14970 ENOG4105K4T epimerase TK34_14975 ENOG4105VDB UPF0125 protein TK34_14980 ENOG4108Z1B Cyclase dehydrase TK34_14985 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) TK34_15000 ENOG4105C9U ATP-dependent DNA helicase RecQ TK34_15005 ENOG4108NZE NAGC-like transcriptional regulator TK34_15010 ENOG4105W8I Transcriptional regulator TK34_15020 ENOG4105BZC d-serine deaminase TK34_15025 ENOG4108HMX isocitrate dehydrogenase (NADP) TK34_15030 ENOG4106R3P AraC family transcriptional regulator TK34_15035 ENOG4105EIP mannose-6-phosphate isomerase TK34_15050 ENOG4105DM4 PTS System TK34_15060 ENOG4105C87 Aminotransferase class I and II TK34_15065 ENOG4105CI1 PTS System TK34_15070 ENOG4107P2S Transcriptional regulator TK34_15080 ENOG4108W0I acetyltransferase TK34_15090 ENOG4105DM4 PTS System TK34_15105 ENOG4105CXY transporter TK34_15110 ENOG4108YRF PTS System TK34_15130 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TK34_15135 ENOG41075W9 High frequency lysogenization protein HflD homolog TK34_15140 ENOG4107QTF adenylosuccinate lyase TK34_15145 ENOG4105EZE Cupin 4 family protein TK34_15155 ENOG4108YYD acetyltransferase TK34_15170 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) TK34_15190 ENOG4105M2J Glutaredoxin TK34_15195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TK34_15200 ENOG410903C (LipO)protein TK34_15205 ENOG4105KWW Biogenesis protein TK34_15210 ENOG4105KWW Biogenesis protein TK34_15215 ENOG4107QX9 Thiol disulfide interChange protein TK34_15220 ENOG4105DA4 cytochrome c-type biogenesis protein TK34_15225 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) TK34_15230 ENOG4105X3C heme exporter protein TK34_15235 ENOG41060IM Heme exporter protein TK34_15240 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) TK34_15255 ENOG4108V3W Chemotaxis protein, CheW TK34_15265 ENOG4107QJE Chromosome Partitioning Protein TK34_15270 ENOG4108SEK ompa motb domain protein TK34_15275 ENOG4105E14 MotA TolQ exbB proton channel TK34_15280 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TK34_15290 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) TK34_15295 ENOG4108VYJ response regulator receiver protein TK34_15300 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TK34_15310 ENOG4105FZW flagellar biosynthesis regulator FlhF TK34_15315 ENOG4105D7B Flagellar biosynthesis protein flha TK34_15320 ENOG4105D00 flagellar biosynthetic protein flhB TK34_15325 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TK34_15330 ENOG4105VS8 Flagellar biosynthetic protein fliq TK34_15335 ENOG4105CN7 Flagellar biosynthetic protein FliP TK34_15340 ENOG4105VTB flagellar biosynthesis protein fliO TK34_15345 ENOG4105DD5 Flagellar motor switch protein TK34_15350 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TK34_15370 ENOG4108JIR Flagellum-specific ATP synthase TK34_15380 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TK34_15385 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) TK34_15390 ENOG4105VQ0 flagellar hook-basal body complex protein fliE TK34_15400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_15405 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TK34_15410 ENOG4105XJC Two component transcriptional regulator (Winged helix family TK34_15425 ENOG4106KNT transcriptional regulator TK34_15430 ENOG4105CA9 Pyruvate kinase TK34_15440 ENOG4105BZS acriflavin resistance protein TK34_15445 ENOG4107QPN acyl-Coa dehydrogenase TK34_15465 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) TK34_15470 ENOG4105C2W permease TK34_15485 ENOG4107R1I NAD-dependent malic enzyme TK34_15490 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_15500 ENOG4105QAX Iron-sulfur TK34_15505 ENOG4108IEG Formate dehydrogenase Alpha subunit TK34_15505 ENOG4108IEG Formate dehydrogenase Alpha subunit TK34_15535 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TK34_15540 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family TK34_15545 ENOG4105BZU Histidine kinase TK34_15550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_15560 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component TK34_15565 ENOG4108IUZ ABC transporter TK34_15570 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) TK34_15575 ENOG4105CVM Molybdenum cofactor synthesis domain protein TK34_15580 ENOG4105DR8 Membrane TK34_15590 ENOG4107SDU Methyl-accepting chemotaxis TK34_15620 ENOG4105XIQ Protein of unknown function (DUF2517) TK34_15640 ENOG4105BZU Histidine kinase TK34_15645 ENOG4108J59 Extracellular solute-binding protein, family 5 TK34_15655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TK34_15665 ENOG4108JQ7 (ABC) transporter TK34_15675 ENOG4105RD7 BadF BadG BcrA BcrD TK34_15680 ENOG4105E2D ec 3.2.1.52 TK34_15685 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor TK34_15695 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TK34_15700 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) TK34_15705 ENOG4105ERU peptidase TK34_15710 ENOG4105UBK short-chain dehydrogenase reductase TK34_15715 ENOG4105C5Q Transcriptional regulator TK34_15725 ENOG4105C87 Aminotransferase class I and II TK34_15740 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis TK34_15745 ENOG4108V1U phospholipid-binding protein TK34_15755 ENOG4107WCA isomerase TK34_15760 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TK34_15765 ENOG4105DR5 peptidase TK34_15770 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) TK34_15775 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) TK34_15780 ENOG4105KME endoribonuclease L-psp TK34_15790 ENOG4105CV1 Transketolase (EC 2.2.1.1) TK34_15795 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TK34_15800 ENOG4105GPY SprT protein TK34_15810 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TK34_15815 ENOG4105D7Z glutathione synthase TK34_15825 ENOG4108UJU UPF0301 protein TK34_15830 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) TK34_15835 ENOG4105DUX Transporter TK34_15840 ENOG41066YJ Beta-lactamase TK34_15845 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TK34_15855 ENOG4105F8C transglutaminase domain-containing protein TK34_15860 ENOG4105BZG amino acid carrier protein TK34_15865 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TK34_15885 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) TK34_15890 ENOG4105CK2 sodium dicarboxylate symporter TK34_15895 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase TK34_15900 ENOG41063JG Transcriptional regulator TK34_15910 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TK34_15915 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TK34_15920 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) TK34_15925 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) TK34_15940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TK34_15945 ENOG4105CGH 5'-nucleotidase TK34_15950 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TK34_15955 ENOG4105C3G gtp-binding protein TK34_16000 ENOG4107QWE )-transporter TK34_16005 ENOG4106Z1T Nicotinamide Mononucleotide Transporter TK34_16010 ENOG4107SXA Phosphorylase TK34_16020 ENOG41060QA UPF0267 protein TK34_16030 ENOG4105CG3 alpha amylase, catalytic region TK34_16040 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TK34_16050 ENOG4107VXZ Hydrolase TK34_16060 ENOG4105C26 Dehydrogenase TK34_16070 ENOG4105C8Y Acetylornithine aminotransferase TK34_16085 ENOG4105C31 Tryptophanyl-tRNA synthetase TK34_16095 ENOG4105DJV ribulose-phosphate 3-epimerase TK34_16100 ENOG4105DFE Dna adenine methylase TK34_16110 ENOG4105D49 3-dehydroquinate synthase TK34_16115 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TK34_16155 ENOG4108JQC penicillin-binding protein 1A TK34_16160 ENOG4105C5Q Transcriptional regulator TK34_16165 ENOG4105C8Q Methyl-accepting chemotaxis TK34_16180 ENOG4105EJC lysr family transcriptional regulator TK34_16195 ENOG4105DR5 peptidase TK34_16205 ENOG4105EGS Mechanosensitive ion channel TK34_16210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TK34_16215 ENOG4105C8Q Methyl-accepting chemotaxis TK34_16225 ENOG4105E33 succinate dehydrogenase TK34_16230 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) TK34_16235 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) TK34_16255 ENOG4105T0Z Conserved Protein TK34_16290 ENOG4105XJC Two component transcriptional regulator (Winged helix family TK34_16295 ENOG4105DHQ Histidine kinase TK34_16315 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TK34_16325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TK34_16330 ENOG4108R5S membrane TK34_16340 ENOG4105C5I Dehydrogenase TK34_16350 ENOG4105BZU Histidine kinase TK34_16360 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 TK34_16375 ENOG4105BZU Histidine kinase TK34_16385 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) TK34_16390 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family TK34_16395 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TK34_16400 ENOG4105C9A Phoh family TK34_16405 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TK34_16410 ENOG4108JU5 Magnesium and cobalt efflux protein TK34_16420 ENOG4107PAI alpha helical protein TK34_16425 ENOG4105C8T Leucyl-tRNA synthetase TK34_16440 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TK34_16445 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) TK34_16450 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) TK34_16455 ENOG4105CJN penicillin-binding protein TK34_16460 ENOG4105CNI cell division protein FtsW TK34_16465 ENOG4105CVE Lytic murein transglycosylase TK34_16470 ENOG4105K6T rare lipoprotein A TK34_16480 ENOG4108Z43 UPF0250 protein TK34_16485 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) TK34_16490 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) TK34_16500 ENOG4105MJ9 esterase TK34_16505 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) TK34_16520 ENOG4107SWG transcriptional regulator MERR family TK34_16525 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TK34_16530 ENOG4105T95 Thiol disulfide interChange protein TK34_16535 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) TK34_16540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TK34_16545 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) TK34_16565 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein TK34_16645 ENOG4105DB1 molybdopterin oxidoreductase TK34_16650 ENOG4106WHD Tetrathionate reductase TK34_16655 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein TK34_16665 ENOG4108ZXC Two component transcriptional regulator, luxr family TK34_16675 ENOG4108NEV two component transcriptional regulator, LytTR family TK34_16685 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) TK34_16700 ENOG41090EX DsrE family TK34_16705 ENOG4105BZU Histidine kinase TK34_16710 ENOG4105E5W Transporter TK34_16715 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TK34_16720 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TK34_16725 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TK34_16730 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) TK34_16735 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TK34_16740 ENOG4105CHV Transcription elongation factor NusA TK34_16745 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) TK34_16765 ENOG4105CP7 Triose-phosphate isomerase TK34_16770 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TK34_16775 ENOG4105EEI dihydropteroate synthase TK34_16780 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TK34_16785 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) TK34_16790 ENOG4105HBR Rna-binding protein TK34_16800 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) TK34_16805 ENOG4107XSU flagellar motor protein motb TK34_16810 ENOG4105E14 MotA TolQ exbB proton channel TK34_16815 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TK34_16820 ENOG4105CTB Polyprenyl synthetase TK34_16825 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TK34_16835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TK34_16845 ENOG4108JQ6 ABC transporter TK34_16850 ENOG4108ZAI phosphatidylglycerophosphatase a TK34_16855 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) TK34_16860 ENOG4107YIM Involved in the transcription termination process (By similarity) TK34_16865 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) TK34_16885 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TK34_16890 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TK34_16900 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TK34_16915 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) TK34_16935 ENOG4105BZU Histidine kinase TK34_16945 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TK34_16950 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) TK34_16955 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein TK34_16960 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TK34_16970 ENOG4108IA2 Sodium pantothenate symporter TK34_16975 ENOG4105CI1 PTS System TK34_16980 ENOG4105HEI LysR family (Transcriptional regulator TK34_16985 ENOG4105CIS alcohol dehydrogenase TK34_16990 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TK34_17000 ENOG41069NU Nitroreductase TK34_17005 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TK34_17010 ENOG4105D07 Signal peptide peptidase, SppA TK34_17030 ENOG4105VUT cytoplasmic protein TK34_17040 ENOG4105D6U Sodium Glutamate Symporter TK34_17045 ENOG4105C8Q Methyl-accepting chemotaxis TK34_17050 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TK34_17055 ENOG4105CRK lysyL-tRNA synthetase TK34_17060 ENOG4107TIF Phenazine biosynthesis protein, PhzF family TK34_17065 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TK34_17070 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) TK34_17075 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) TK34_17080 ENOG4105GIJ Glycine betaine TK34_17085 ENOG4108HQS Glycine betaine TK34_17090 ENOG4108IJ7 Glycine betaine TK34_17100 ENOG4107XM3 UPF0442 protein TK34_17105 ENOG4105DWK Membrane TK34_17115 ENOG4108RIR Molybdenum cofactor biosynthesis protein TK34_17125 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TK34_17130 ENOG4105C2D reductase TK34_17140 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TK34_17165 ENOG4105C84 Histidine ammonia-lyase TK34_17195 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TK34_17230 ENOG4105CA0 peroxidase TK34_17240 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) TK34_17245 ENOG4105DD7 kinase (PfkB family TK34_17250 ENOG4107QZF nitrite reductase NADPH large subunit TK34_17255 ENOG4107QZF nitrite reductase NADPH large subunit TK34_17260 ENOG4105D7T ABC transporter TK34_17265 ENOG4105DG7 nitrate ABC transporter TK34_17270 ENOG4105D7T ABC transporter TK34_17280 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TK34_17310 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) TK34_17320 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) TK34_17325 ENOG4105V1F Fermentation respiration switch protein TK34_17330 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) TK34_17335 ENOG4105CIN aminoacyl-histidine dipeptidase TK34_17340 ENOG4108JQ7 (ABC) transporter TK34_17355 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component TK34_17360 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component TK34_17365 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) TK34_17385 ENOG4109015 Biopolymer transport protein exbD tolR TK34_17440 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TK34_17445 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TK34_17450 ENOG4105C8Q Methyl-accepting chemotaxis TK34_17460 ENOG4105VEQ Cold shock protein TK34_17500 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) TK34_17505 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TK34_17510 ENOG4105DJ4 phosphatidylserine decarboxylase TK34_17515 ENOG4105VYA Uncharacterized conserved protein (DUF2132) TK34_17535 ENOG4108KBJ Inner membrane protein YkgB TK34_17545 ENOG4108K01 transcriptional regulator TK34_17555 ENOG4105BZU Histidine kinase TK34_17560 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) TK34_17565 ENOG4107G87 m6 family metalloprotease domain protein TK34_17585 ENOG4105BZ1 (ABC) transporter TK34_17590 ENOG4105SUV lipoprotein YgdR TK34_17600 ENOG4107RM6 sulfurtransferase TK34_17605 ENOG4105CSV Glutaminase TK34_17610 ENOG41090ED Protein with unknown function (DUF469) TK34_17615 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) TK34_17620 ENOG4105IIU Aminopeptidase TK34_17625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TK34_17630 ENOG4105BZU Histidine kinase TK34_17635 ENOG4105ECP epimerase TK34_17640 ENOG4105CV6 ABC transporter, permease TK34_17645 ENOG4108I0Y (ABC) transporter TK34_17650 ENOG4108UJV acyl-CoA thioesterase i TK34_17655 ENOG4107R88 Chemotaxis protein (CheV) TK34_17665 ENOG4105D0C transport protein TK34_17670 ENOG4108UT2 hemolysin iii TK34_17675 ENOG4105DY8 decarboxylase TK34_17680 ENOG4107835 probably involved in intracellular septation (By similarity) TK34_17685 ENOG4105K9H YciI-like protein TK34_17690 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase TK34_17695 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein TK34_17700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase TK34_17705 ENOG4105DUX Transporter TK34_17710 ENOG4105I93 response regulator TK34_17740 ENOG4107V40 secretion protein, HlyD family TK34_17750 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TK34_17755 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) TK34_17760 ENOG4108NIW Leucine export protein LeuE TK34_17790 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) TK34_17795 ENOG4105D3G Pseudouridine synthase TK34_17805 ENOG4105BZU Histidine kinase TK34_17815 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TK34_17820 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TK34_17825 ENOG4107QI1 Mate efflux family protein TK34_17830 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 TK34_17835 ENOG4108IJ0 Aspartate ammonia-lyase TK34_17840 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter TK34_17855 ENOG4105EV4 Multidrug resistance protein mdtH TK34_17870 ENOG4108Z9I -acetyltransferase TK34_17875 ENOG4105D9U N-acetyltransferase TK34_17885 ENOG4105D9R oxidoreductase TK34_17895 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TK34_17900 ENOG4105CSA Coproporphyrinogen iii oxidase TK34_17910 ENOG4105NAE bifunctional deaminase-reductase domain protein TK34_17920 ENOG4105DC1 bifunctional purine biosynthesis protein purh TK34_17925 ENOG4105C12 Phosphoribosylglycinamide synthetase TK34_18000 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TK34_18005 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TK34_18010 ENOG4105KTH gatB Yqey TK34_18015 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TK34_18025 ENOG4108K5P (LipO)protein TK34_18030 ENOG4108UM1 dedA family TK34_18035 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TK34_18040 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) TK34_18045 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) TK34_18050 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TK34_18055 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) TK34_18060 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) TK34_18065 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TK34_18070 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TK34_18075 ENOG4105DXN mazG family TK34_18080 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TK34_18085 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TK34_18090 ENOG4105BZU Histidine kinase TK34_18095 ENOG4108W15 Protein of unknown function (DUF1456) TK34_18100 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase TK34_18105 ENOG4105E98 transcriptional regulator DeoR family TK34_18110 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of TK34_18115 ENOG4105E70 isomerase TK34_18120 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB TK34_18130 ENOG4105F3R pts system mannose fructose sorbose family iid TK34_18135 ENOG4108YTN IIa component TK34_18140 ENOG4105CE4 GlcNAc 6-P deacetylase TK34_18145 ENOG4105D2N Aldolase TK34_18155 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) TK34_18160 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) TK34_18175 ENOG4105C3F Signal peptidase i TK34_18180 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TK34_18195 ENOG41069PW sigma-e factor negative regulatory protein TK34_18200 ENOG4105EMN RNA polymerase sigma factor TK34_18205 ENOG4108IYU L-aspartate oxidase TK34_18215 ENOG4105Y75 tpr repeat protein TK34_18245 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) TK34_18255 ENOG4105CJP fad dependent oxidoreductase TK34_18260 ENOG4105D2N Aldolase TK34_18265 ENOG4105BZA Phosphoglycerate kinase TK34_18270 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TK34_18275 ENOG4105DKQ ROK family TK34_18280 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) TK34_18285 ENOG4105E09 nadh pyrophosphatase TK34_18290 ENOG4105C26 Dehydrogenase TK34_18300 ENOG4105EYW Ion transport protein TK34_18305 ENOG4105C8Q Methyl-accepting chemotaxis TK34_18315 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) TK34_18320 ENOG4105CYX Short-chain dehydrogenase reductase Sdr TK34_18345 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) TK34_18350 ENOG4105EAD ABC transporter TK34_18355 ENOG4105E5Q amino acid AbC transporter TK34_18360 ENOG4105CDA abc transporter atp-binding protein TK34_18365 ENOG4105CT1 (ABC) transporter TK34_18370 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TK34_18375 ENOG4105DJY efflux transporter, rnd family, mfp subunit TK34_18380 ENOG4105E3W Two component transcriptional regulator (Winged helix family TK34_18385 ENOG4105E0F Histidine kinase TK34_18390 ENOG4105E09 nadh pyrophosphatase TK34_18420 ENOG4105EA8 2-Nitropropane dioxygenase TK34_18445 ENOG4105CA0 peroxidase TK34_18450 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase TK34_18470 ENOG4106B0W Curli production assembly transport component CsgG TK34_18480 ENOG4107Y60 (LipO)protein TK34_18485 ENOG4105C1J atp-dependent rna helicase TK34_18495 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) TK34_18510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TK34_18515 ENOG4105DWY Agmatine deiminase TK34_18530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TK34_18535 ENOG4108MJ3 acetyltransferase TK34_18560 ENOG4105BZU Histidine kinase TK34_18565 ENOG4105BZU Histidine kinase TK34_18585 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) TK34_18595 ENOG4105KEG ribosomal-protein-alanine acetyltransferase TK34_18605 ENOG4108IQE Amp-dependent synthetase and ligase TK34_18615 ENOG4105D9M gamma-glutamylcysteine synthetase TK34_18625 ENOG4105W39 Membrane TK34_18645 ENOG4105DP0 ferredoxin-NADP reductase TK34_18650 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TK34_18655 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TK34_18660 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) TK34_18665 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) TK34_18685 ENOG4107YB6 acetyltransferase, (GNAT) family TK34_18700 ENOG4105C2N RNA methyltransferase TrmH family group 3 TK34_18705 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) TK34_18710 ENOG4106TD9 Diguanylate cyclase TK34_18715 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) TK34_18725 ENOG4108YZA Nitrogen regulatory protein pii TK34_18730 ENOG4105C4K Nad synthetase TK34_18790 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) TK34_18795 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase TK34_18800 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TK34_18805 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TK34_18810 ENOG4105DTN riboflavin biosynthesis protein ribF TK34_18815 ENOG4105CJR Integral membrane protein (MviN TK34_18820 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) TK34_18825 ENOG41080HT Transcriptional regulator, arsr family TK34_18830 ENOG41063Z6 transcriptional regulator, lysR family TK34_18840 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) TK34_18845 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) TK34_18850 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TK34_18855 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase TK34_18870 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) TK34_18880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TK34_18885 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TK34_18890 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TK34_18895 ENOG4105K5M 30s ribosomal protein S16 TK34_18900 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY TK34_18905 ENOG4106KVJ cytochrome C assembly protein TK34_18910 ENOG4108JU6 CBS domain protein TK34_18920 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) TK34_18925 ENOG4108UV7 flagellar protein motX TK34_18935 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TK34_18940 ENOG4105DMR ABC, transporter TK34_18945 ENOG4105GBT ABC transporter TK34_18950 ENOG4106PMH Extracellular solute-binding protein family 3 TK34_18955 ENOG4105E5Z arginine transporter ATP-binding subunit TK34_18960 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) TK34_18965 ENOG4105EZR dyp-type peroxidase family protein TK34_18970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TK34_18985 ENOG4108YZA Nitrogen regulatory protein pii TK34_18990 ENOG4108YZN class I peptide chain release factor TK34_19000 ENOG4105D9N nucleoside TK34_19005 ENOG4105HEI LysR family (Transcriptional regulator TK34_19020 ENOG4105BZW Glycerate kinase TK34_19025 ENOG4107QQ0 gntp family TK34_19030 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR TK34_19035 ENOG4105XTV UPF0231 protein TK34_19050 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor TK34_19055 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) TK34_19070 ENOG4105C1J atp-dependent rna helicase TK34_19080 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) TK34_19100 ENOG4105PGM cation diffusion facilitator family transporter TK34_19110 ENOG4105CGF Aromatic amino acid aminotransferase TK34_19125 ENOG41076CZ activating enzyme TK34_19130 ENOG4105G0K glycine radical enzyme YjjI family TK34_19150 ENOG4107RE3 peptidase, S41 TK34_19180 ENOG4105C8Q Methyl-accepting chemotaxis TK34_19185 ENOG4108M1A Chitin-binding protein TK34_19190 ENOG4107R11 Transcriptional regulator TK34_19195 ENOG4108IJ6 ABC transporter TK34_19200 ENOG4105ECW sulfate abc transporter TK34_19205 ENOG4108I5D sulfate abc transporter TK34_19215 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein TK34_19220 ENOG4107PU6 Membrane TK34_19225 ENOG4108UW5 maltose o-acetyltransferase TK34_19250 ENOG4105CH7 arginosuccinase TK34_19255 ENOG4105CDH Citrulline--aspartate ligase TK34_19265 ENOG4105CAS nag kinase TK34_19270 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase TK34_19280 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) TK34_19290 ENOG4105CFH Aspartokinase TK34_19295 ENOG4105C28 cystathionine TK34_19300 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) TK34_19305 ENOG41086D8 Transcriptional regulator TK34_19310 ENOG4108Z7R Chaperone CsaA TK34_19315 ENOG4105C44 Serine transporter TK34_19320 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase TK34_19325 ENOG4107RK2 ADP-ribose diphosphatase NudE TK34_19330 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 TK34_19335 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TK34_19340 ENOG4108UDW Transcriptional regulator, luxr family TK34_19380 ENOG4108VAU general secretion pathway protein G TK34_19385 ENOG4105D7Q type ii secretion system TK34_19390 ENOG4107QHF type ii secretion system protein e TK34_19395 ENOG4105GVR general secretion pathway protein D TK34_19405 ENOG4105VEJ Heat shock protein TK34_19410 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) TK34_19415 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase TK34_19430 ENOG4105VXR cytoplasmic protein TK34_19435 ENOG4108R6G acetyltransferase TK34_19440 ENOG4108XTF Outer Membrane Lipoprotein TK34_19450 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic TK34_19455 ENOG4108ZUB Lysine exporter protein (Lyse ygga) TK34_19460 ENOG4105VJY transcriptional regulator TK34_19465 ENOG4105NNS Autoinducer synthesis protein TK34_19470 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) TK34_19475 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) TK34_19490 ENOG4105CTS PTS system mannitol-specific TK34_19495 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase TK34_19500 ENOG4105E61 Mannitol repressor protein TK34_19505 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) TK34_19530 ENOG4108UPT UPF0178 protein TK34_19535 ENOG4107K5X Membrane-bound metal-dependent hydrolase TK34_19540 ENOG4105D9N nucleoside TK34_19545 ENOG4105C1J atp-dependent rna helicase TK34_19570 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase TK34_19575 ENOG4105E4F Isochorismate synthase TK34_19580 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) TK34_19585 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) TK34_19590 ENOG4108IPT Naphthoate synthase TK34_19595 ENOG4105DNI Converts SHCHC to OSB (By similarity) TK34_19600 ENOG4105CEY Amp-dependent synthetase and ligase TK34_19615 ENOG4108MDY Fimbrial TK34_19620 ENOG4108FZ9 Chaperone TK34_19625 ENOG4106PG1 outer membrane usher protein TK34_19635 ENOG4105HMV Fimbrial protein TK34_19645 ENOG4107MM9 BNR Asp-box repeat-containing protein TK34_19650 ENOG4108UB4 uncharacterized protein ygjQ TK34_19655 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TK34_19665 ENOG4107IFA Lipase (EC 3.1.1.3) TK34_19685 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) TK34_19690 ENOG4108IQK o-acetylhomoserine TK34_19700 ENOG4108I6A alcohol dehydrogenase TK34_19715 ENOG4105DZW Dipeptidase TK34_19720 ENOG4105EMU Dehydrogenase TK34_19740 ENOG4105KT7 mgtC SapB transporter TK34_19760 ENOG4105E0M Sulfatase TK34_19765 ENOG4108YXU transcriptional regulator AsnC family TK34_19775 ENOG4105CVG Homoserine O-transsuccinylase TK34_19780 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) TK34_19785 ENOG4108I62 cina-like protein TK34_19795 ENOG4105CJ1 ABC, transporter TK34_19810 ENOG410667J hydrolase TK34_19815 ENOG4108Z86 Glutamine amidotransferase TK34_19825 ENOG4107RYR Transcriptional regulator, Crp Fnr family TK34_19835 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant TK34_19840 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TK34_19850 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) TK34_19855 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TK34_19860 ENOG4105XQ6 frataxin-like protein TK34_19865 ENOG4106CJB Phospholipase Carboxylesterase TK34_19870 ENOG4107T0K Adenylate cyclase TK34_19875 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) TK34_19880 ENOG41076E6 Uroporphyrinogen-III Synthase TK34_19885 ENOG4105ECF c-methyltransferase TK34_19900 ENOG4105CBT Fructose-1,6-bisphosphatase TK34_19915 ENOG4105E0K tonB-dependent siderophore receptor TK34_19940 ENOG4105KVH Transcriptional regulator TK34_19945 ENOG4105N0V mono-oxygenase ydhR TK34_19960 ENOG4108TPP exopolysaccharide synthesis TK34_19965 ENOG4105C44 Serine transporter TK34_19970 ENOG4105BZU Histidine kinase TK34_19990 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) TK34_20000 ENOG4105D41 biosynthesis protein thiH TK34_20005 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) TK34_20015 ENOG4105D06 uba thif-type nad fad binding protein TK34_20020 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) TK34_20025 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) TK34_20030 ENOG4106032 Glutathionylspermidine synthase TK34_20035 ENOG4105Z6B inner membrane protein yjfl TK34_20055 ENOG4105ETX regulatoR TK34_20065 ENOG4105CWM branched-chain amino acid transport system II carrier protein TK34_20070 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) TK34_20075 ENOG4105C3R Methionine synthase TK34_20080 ENOG4105EEQ Na H antiporter TK34_20090 ENOG4108HU6 Metal dependent phosphohydrolase TK34_20100 ENOG4105CGZ zinc metallopeptidase TK34_20105 ENOG4105F0S class B acid phosphatase TK34_20120 ENOG4107SDU Methyl-accepting chemotaxis TK34_20125 ENOG4107MMM Anti-sigma-factor antagonist TK34_20130 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase TK34_20135 ENOG4105BZU Histidine kinase TK34_20140 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TK34_20150 ENOG4105CSH Transporter TK34_20165 ENOG4105D1U peptidase U62 modulator of DNA gyrase TK34_20180 ENOG4105QD6 exported protein TK34_20185 ENOG4105C03 ribonuclease TK34_20190 ENOG4108Z03 MAF-like protein TK34_20195 ENOG4105VQ7 Rod shape-determining protein MreD TK34_20200 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) TK34_20205 ENOG4105DFF Rod shape-determining protein mreb TK34_20255 ENOG4105D7Q type ii secretion system TK34_20260 ENOG4107QHF type ii secretion system protein e TK34_20275 ENOG4105GVR general secretion pathway protein D TK34_20305 ENOG41062P1 Diguanylate cyclase phosphodiesterase TK34_20310 ENOG4107XTP (EAL) domain protein TK34_20315 ENOG4105EWV Sodium calcium exchanger membrane region TK34_20320 ENOG4105C84 Histidine ammonia-lyase TK34_20325 ENOG4105CGP Urocanate hydratase TK34_20330 ENOG41088SP formiminoglutamate hydrolase TK34_20335 ENOG4105CI2 imidazolone-5-propionate hydrolase TK34_20340 ENOG4105CZE histidine utilization repressor TK34_20345 ENOG41077A9 carbonic anhydrase TK34_20355 ENOG4105CRP Part of the ABC transporter FtsEX involved in TK34_20360 ENOG4105CAK Cell division ATP-binding protein ftsE TK34_20365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TK34_20370 ENOG4106H78 methyltransferase TK34_20380 ENOG4108Y73 Membrane TK34_20385 ENOG4105EJ2 Transcriptional regulator TK34_20395 ENOG4107RZC phospholipase d TK34_20400 ENOG4105E4C Lytic transglycosylase catalytic TK34_20410 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) TK34_20420 ENOG41076UM multiple antibiotic resistance (MarC)-related protein TK34_20425 ENOG4105VVZ metal-binding protein TK34_20440 ENOG4105JQN Transcriptional regulator TK34_20455 ENOG4107FS9 Membrane TK34_20470 ENOG4105CUG Oligopeptidase b TK34_20485 ENOG4105EMU Dehydrogenase TK34_20490 ENOG4108W5M transcriptional regulator TK34_20495 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein TK34_20545 ENOG4108ZT0 50S ribosomal protein l17 TK34_20550 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TK34_20555 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TK34_20560 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TK34_20570 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TK34_20575 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TK34_20580 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TK34_20585 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) TK34_20590 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TK34_20595 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TK34_20600 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TK34_20605 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TK34_20610 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) TK34_20615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) TK34_20620 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TK34_20625 ENOG41083MP 50s ribosomal protein l29 TK34_20630 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) TK34_20635 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TK34_20640 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) TK34_20645 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) TK34_20650 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TK34_20655 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TK34_20660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TK34_20665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TK34_20670 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) TK34_20680 ENOG4105E0F Histidine kinase TK34_20685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TK34_20690 ENOG4108RRZ Transcription elongation factor GreB TK34_20695 ENOG4105BZM domain protein TK34_20715 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) TK34_20725 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) TK34_20730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TK34_20735 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) TK34_20740 ENOG4107YZP Rhodanese domain protein TK34_20745 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TK34_20750 ENOG41063SB peptidase TK34_20760 ENOG4105DIQ Transcriptional regulator TK34_20765 ENOG4108UHU Aldolase TK34_20770 ENOG4105C01 Dihydroxy-acid dehydratase TK34_20775 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family TK34_20780 ENOG4105C6Z Gluconate TK34_20785 ENOG4105JIM Phosphatidylserine synthase TK34_20790 ENOG4105CB5 ATP-dependent DNA helicase recG TK34_20800 ENOG4105SUU thioesterase domain TK34_20815 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) TK34_20820 ENOG4107S2Z UPF0761 membrane protein TK34_20825 ENOG4107S2Z UPF0761 membrane protein TK34_20835 ENOG4105C5F glutamine synthetase TK34_20845 ENOG4105CUX Signal transduction histidine kinase TK34_20850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TK34_20855 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TK34_20860 ENOG4105D4P Coproporphyrinogen iii oxidase TK34_20865 ENOG4105XCT Protein of unknown function (DUF2489) TK34_20870 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) TK34_20875 ENOG4106RE7 Cytochrome TK34_20880 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) TK34_20885 ENOG4105SG3 Protein of unknown function (DUF1488) TK34_20890 ENOG4105E2X shikimate dehydrogenase TK34_20895 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) TK34_20900 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TK34_20910 ENOG4108WI1 Dna topoisomerase TK34_20915 ENOG4108RPN Protein smg homolog TK34_20920 ENOG4105C79 DNA protecting protein DprA TK34_20930 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TK34_20935 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TK34_20940 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TK34_20945 ENOG4105C1A potassium transporter peripheral membrane TK34_20950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) TK34_20975 ENOG4105D7K pfkb domain protein TK34_20980 ENOG4105DCF alanine dehydrogenase TK34_20985 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TK34_20990 ENOG4105C26 Dehydrogenase TK34_21000 ENOG4108JCI Transcriptional regulator TK34_21005 ENOG4105C26 Dehydrogenase TK34_21010 ENOG4105FR1 rard protein TK34_21015 ENOG4105ECQ AraC Family Transcriptional Regulator TK34_21025 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic TK34_21030 ENOG4105CUC YeeE YedE family protein TK34_21035 ENOG410829K Lysine exporter protein (Lyse ygga) TK34_21045 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) TK34_21070 ENOG41061EV selenium-binding protein YdfZ TK34_21090 ENOG4105HEI LysR family (Transcriptional regulator TK34_21100 ENOG4105C4R Atp-dependent dna helicase TK34_21105 ENOG4105DIH basic membrane TK34_21110 ENOG4108JQ9 ABC transporter TK34_21115 ENOG4105UIB (ABC) transporter TK34_21125 ENOG4105CC0 LysR family Transcriptional regulator TK34_21145 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process TK34_21150 ENOG4105DHU Bile acid TK34_21155 ENOG4105E5D amino acid TK34_21160 ENOG4108Y51 tRNA-binding protein TK34_21165 ENOG4105E5D amino acid TK34_21170 ENOG4105FK9 beta-D-galactosidase beta subunit TK34_21180 ENOG4105CQ4 Transcriptional regulator TK34_21215 ENOG4108Z0R Transferase TK34_21220 ENOG4105C2M dna polymerase I TK34_21225 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain TK34_21230 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) TK34_21240 ENOG4105D7W serine acetyltransferase TK34_21250 ENOG4105E3W Two component transcriptional regulator (Winged helix family TK34_21255 ENOG4105E0F Histidine kinase TK34_21260 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) TK34_21265 ENOG4107R73 Mate efflux family protein TK34_21280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) TK34_21285 ENOG4105E55 glycerol-3-phosphate acyltransferase TK34_21295 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) TK34_21300 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) TK34_21305 ENOG4105X6C Flagellar basal body-associated protein FliL TK34_21315 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family TK34_21320 ENOG4105DIQ Transcriptional regulator TK34_21340 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase TK34_21345 ENOG4105XA0 heptosyltransferase ii TK34_21350 ENOG4106WTF Glycosyl transferase, family 2 TK34_21355 ENOG4105M5K heptosyltransferase TK34_21360 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TK34_21365 ENOG4108MJ5 VirK protein TK34_21370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) TK34_21380 ENOG4105W0E 50S ribosomal protein L33 TK34_21385 ENOG4105W5Q DNA repair protein (RadC TK34_21390 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase TK34_21395 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TK34_21400 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) TK34_21405 ENOG4105D64 Mechanosensitive ion channel TK34_21415 ENOG4107QP8 phosphohexose isomerase TK34_21420 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TK34_21425 ENOG4105EMY transcriptional regulator TK34_21440 ENOG4105CD5 CoA-binding domain protein TK34_21465 ENOG4108RR8 protoporphyrinogen oxidase TK34_21470 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) TK34_21475 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TK34_21480 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) TK34_21485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TK34_21490 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TK34_21495 ENOG4105CHU acetyl-coa acetyltransferase TK34_21500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TK34_21505 ENOG4105E0F Histidine kinase TK34_21520 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) TK34_21525 ENOG4105M4H endoribonuclease L-psp TK34_21530 ENOG4108ZG0 Ompa motb domain protein TK34_21535 ENOG4105D3W isochorismatase TK34_21540 ENOG4108R3E Dna-3-methyladenine glycosylase i TK34_21545 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit TK34_21550 ENOG4105C38 Glycyl-tRNA synthetase beta subunit TK34_21555 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TK34_21580 ENOG41072JS exoenzyme T TK34_21600 ENOG4105CIC tryptophan-specific transport protein TK34_21605 ENOG4105HEE Binding Domain protein TK34_21615 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase TK34_21620 ENOG4105CNW domain protein TK34_21625 ENOG4108JUA Transcriptional regulator TK34_21635 ENOG4105CI1 PTS System TK34_21640 ENOG4105F8D glycoside hydrolase family 4 TK34_21645 ENOG4105ETE Transcriptional regulator (LacI family TK34_21650 ENOG4105CP9 extracellular ligand-binding receptor TK34_21655 ENOG4105C32 Amino acid ABC transporter (Permease) TK34_21660 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TK34_21665 ENOG4105C0Z ABC transporter TK34_21670 ENOG4108IV0 ABC, transporter TK34_21685 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) TK34_21700 ENOG4105W0Z cytoplasmic protein TK34_21705 ENOG4107QK7 reductase TK34_21710 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) TK34_21720 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TK34_21725 ENOG4105K63 Thioredoxin TK34_21730 ENOG4105C1J atp-dependent rna helicase TK34_21735 ENOG4105C9X ppx gppa phosphatase TK34_21750 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) TK34_21755 ENOG4105BZU Histidine kinase TK34_21760 ENOG4105DGW oligopeptidase A TK34_21765 ENOG4105D52 delta-aminolevulinic acid dehydratase TK34_21770 ENOG4105F8V Hydrolase, tatD family TK34_21775 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) TK34_21780 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) TK34_21785 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) TK34_21790 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) TK34_21795 ENOG4105JC1 sterol-binding domain protein TK34_21805 ENOG4105WMR Protein CrcB homolog TK34_21810 ENOG4105DZC cytosine deaminase TK34_21850 ENOG410822N TonB family TK34_21855 ENOG4109015 Biopolymer transport protein exbD tolR TK34_21875 ENOG4105VJY transcriptional regulator TK34_21880 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) TK34_21885 ENOG410804X Transcriptional regulator TK34_21890 ENOG4105E3W Two component transcriptional regulator (Winged helix family TK34_21895 ENOG4105EB3 Histidine kinase TK34_21905 ENOG4105CT7 inner membrane cred family protein TK34_21910 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) TK34_21915 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TK34_21920 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) TK34_21925 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) TK34_21930 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) TK34_21935 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) TK34_21945 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) TK34_21950 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) TK34_21960 ENOG4105FA0 parb-like partition protein TK34_21965 ENOG4107QJE Chromosome Partitioning Protein TK34_21970 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TK34_21975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TK34_21980 ENOG4105QTB Flavodoxin TK34_21985 ENOG4105E0K tonB-dependent siderophore receptor TK34_21990 ENOG4105IBP Cyclic peptide transporter TK34_21995 ENOG4105E0A ABC, transporter TK34_22005 ENOG4105S6R Iron-hydroxamate transporter permease subunit TK34_22010 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TK34_22015 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TK34_22020 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) TK34_22025 ENOG4105VG0 50S ribosomal protein l34 TK34_22030 ENOG4105CDA abc transporter atp-binding protein TK34_22035 ENOG4105E5Q amino acid AbC transporter TK34_22040 ENOG4105EAB amino acid AbC transporter TK34_22075 ENOG4108J4B Beta-lactamase TK34_22080 ENOG4105MVE transcriptional regulator TK34_22445 ENOG4105E4C Lytic transglycosylase catalytic TK34_22585 ENOG4105EKQ RNA-directed DNA polymerase TK34_22615 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TK34_22720 ENOG4105BZU Histidine kinase TK34_22785 ENOG4105CHH sulfate transporter