locus-tag	class	description
GCK65_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCK65_00010	COG0592	DNA-directed DNA polymerase activity
GCK65_00030	COG2378	regulation of single-species biofilm formation
GCK65_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GCK65_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GCK65_00045	COG3977	Valine--pyruvate aminotransferase
GCK65_00060	COG2814	Major facilitator Superfamily
GCK65_00065	COG0745	RESPONSE REGULATOR receiver
GCK65_00070	COG2205	protein histidine kinase activity
GCK65_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCK65_00100	COG4191	Histidine kinase
GCK65_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCK65_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_00115	COG1309	transcriptional regulator
GCK65_00145	COG0469	pyruvate kinase activity
GCK65_00150	COG2271	Major facilitator Superfamily
GCK65_00175	COG0561	phosphatase activity
GCK65_00180	COG2267	carboxylic ester hydrolase activity
GCK65_00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCK65_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCK65_00195	COG1758	RNA polymerase activity
GCK65_00205	COG0859	PFAM glycosyl transferase family 9
GCK65_00210	COG3642	lipopolysaccharide core region biosynthetic process
GCK65_00250	COG0589	response to stress
GCK65_00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GCK65_00265	COG1528	Iron-storage protein
GCK65_00270	COG2081	HI0933 family
GCK65_00275	COG2223	nitrite transmembrane transporter activity
GCK65_00295	COG3188	usher protein
GCK65_00315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_00315	COG2205	protein histidine kinase activity
GCK65_00325	COG3275	phosphorelay sensor kinase activity
GCK65_00330	COG3279	Response regulator of the LytR AlgR family
GCK65_00335	COG2223	nitrite transmembrane transporter activity
GCK65_00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GCK65_00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GCK65_00360	COG0583	DNA-binding transcription factor activity
GCK65_00365	COG4206	TonB-dependent receptor
GCK65_00370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GCK65_00405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GCK65_00410	COG2166	iron-sulfur cluster assembly
GCK65_00415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GCK65_00420	COG0210	DNA helicase
GCK65_00430	COG3245	cytochrome
GCK65_00435	COG1063	alcohol dehydrogenase
GCK65_00440	COG0156	8-amino-7-oxononanoate synthase activity
GCK65_00450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCK65_00465	COG3306	glycosyltransferase involved in LPS biosynthesis
GCK65_00485	COG3171	Protein conserved in bacteria
GCK65_00490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCK65_00495	COG1518	maintenance of DNA repeat elements
GCK65_00505	COG1857	crispr-associated protein
GCK65_00565	COG1561	YicC-like family, N-terminal region
GCK65_00570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GCK65_00575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GCK65_00585	COG0789	Transcriptional regulator
GCK65_00590	COG2203	Gaf domain
GCK65_00590	COG5001	Diguanylate cyclase
GCK65_00590	COG4251	negative regulation of phosphorylation
GCK65_00590	COG3706	GGDEF domain
GCK65_00595	COG3084	Protein conserved in bacteria
GCK65_00605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GCK65_00610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCK65_00620	COG1335	isochorismatase
GCK65_00630	COG1683	Conserved Protein
GCK65_00635	COG0204	Acyl-transferase
GCK65_00640	COG0204	Acyl-transferase
GCK65_00645	COG0606	chelatase, subunit chli
GCK65_00660	COG3978	acetolactate synthase activity
GCK65_00670	COG0129	dihydroxy-acid dehydratase activity
GCK65_00690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GCK65_00695	COG0254	rRNA binding
GCK65_00700	COG0702	epimerase
GCK65_00705	COG0281	malic enzyme
GCK65_00715	COG2205	protein histidine kinase activity
GCK65_00720	COG0745	RESPONSE REGULATOR receiver
GCK65_00725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCK65_00760	COG4310	Domain of unknown function (DUF2172)
GCK65_00780	COG2089	acid synthase
GCK65_00790	COG1083	cytidylyl-transferase
GCK65_00805	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_00810	COG0318	PFAM AMP-dependent synthetase and ligase
GCK65_00825	COG1215	transferase activity, transferring glycosyl groups
GCK65_00850	COG0859	PFAM glycosyl transferase family 9
GCK65_00855	COG2226	methyltransferase
GCK65_00865	COG2192	nodulation
GCK65_00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GCK65_00880	COG1086	Polysaccharide biosynthesis protein
GCK65_00885	COG0366	Alpha amylase catalytic
GCK65_00900	COG0443	Heat shock 70 kDa protein
GCK65_00905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCK65_00910	COG3045	CreA protein
GCK65_00930	COG0174	glutamine synthetase
GCK65_00950	COG3842	ATPase activity
GCK65_00955	COG1176	ABC-type spermidine putrescine transport system, permease component I
GCK65_00960	COG1177	transmembrane transport
GCK65_00965	COG2258	MOSC domain
GCK65_00980	COG2050	protein possibly involved in aromatic compounds catabolism
GCK65_00985	COG0514	ATP-dependent DNA helicase (RecQ)
GCK65_00995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GCK65_01005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GCK65_01010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GCK65_01020	COG2239	Acts as a magnesium transporter
GCK65_01025	COG1648	precorrin-2 dehydrogenase activity
GCK65_01025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GCK65_01030	COG2116	formate transmembrane transporter activity
GCK65_01040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCK65_01055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GCK65_01060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GCK65_01085	COG1595	DNA-templated transcription, initiation
GCK65_01090	COG3806	Anti-sigma factor
GCK65_01095	COG1968	undecaprenyl-diphosphatase activity
GCK65_01100	COG0667	Aldo Keto reductase
GCK65_01105	COG2017	converts alpha-aldose to the beta-anomer
GCK65_01110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GCK65_01120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCK65_01125	COG1609	Transcriptional regulator
GCK65_01130	COG3250	beta-galactosidase activity
GCK65_01150	COG0840	transmembrane signaling receptor activity
GCK65_01180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GCK65_01185	COG1288	antiporter activity
GCK65_01190	COG1438	arginine binding
GCK65_01195	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GCK65_01200	COG0540	Belongs to the ATCase OTCase family
GCK65_01215	COG0688	phosphatidylethanolamine metabolic process
GCK65_01225	COG3040	lipid binding
GCK65_01230	COG2207	Transcriptional regulator
GCK65_01235	COG1979	alcohol dehydrogenase
GCK65_01240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GCK65_01245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GCK65_01255	COG3681	Belongs to the UPF0597 family
GCK65_01265	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCK65_01270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCK65_01275	COG0564	pseudouridine synthase activity
GCK65_01285	COG0542	response to heat
GCK65_01290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GCK65_01300	COG2502	aspartate--ammonia ligase
GCK65_01305	COG1522	sequence-specific DNA binding
GCK65_01315	COG5413	integral membrane protein
GCK65_01320	COG0516	GMP reductase activity
GCK65_01320	COG0517	IMP dehydrogenase activity
GCK65_01340	COG2205	protein histidine kinase activity
GCK65_01350	COG2204	response regulator
GCK65_01370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GCK65_01400	COG0243	molybdopterin cofactor binding
GCK65_01405	COG3005	denitrification pathway
GCK65_01410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCK65_01415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCK65_01420	COG0569	domain protein
GCK65_01425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GCK65_01450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCK65_01465	COG0250	Participates in transcription elongation, termination and antitermination
GCK65_01470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GCK65_01475	COG0081	regulation of translation
GCK65_01480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GCK65_01485	COG0222	ribosome binding
GCK65_01490	COG0085	RNA polymerase activity
GCK65_01495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GCK65_01500	COG2964	Protein conserved in bacteria
GCK65_01505	COG0251	oxidation-reduction process
GCK65_01515	COG2923	Belongs to the DsrF TusC family
GCK65_01520	COG2168	tRNA wobble position uridine thiolation
GCK65_01525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GCK65_01530	COG0049	tRNA binding
GCK65_01535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GCK65_01540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCK65_01545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCK65_01580	COG2252	PERMEase
GCK65_01585	COG2376	Dihydroxyacetone kinase
GCK65_01590	COG1461	Dihydroxyacetone kinase
GCK65_01615	COG2957	Belongs to the agmatine deiminase family
GCK65_01625	COG0628	permease
GCK65_01630	COG0494	nUDIX hydrolase
GCK65_01655	COG0753	catalase activity
GCK65_01660	COG1247	-acetyltransferase
GCK65_01680	COG3706	GGDEF domain
GCK65_01690	COG3842	ATPase activity
GCK65_01700	COG1175	transmembrane transport
GCK65_01730	COG0583	DNA-binding transcription factor activity
GCK65_01740	COG1741	Belongs to the pirin family
GCK65_01745	COG2259	Doxx family
GCK65_01750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GCK65_01755	COG1074	ATP-dependent DNA helicase activity
GCK65_01760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCK65_01770	COG0346	lactoylglutathione lyase activity
GCK65_01815	COG3706	GGDEF domain
GCK65_01820	COG4771	TonB-dependent receptor
GCK65_01825	COG1278	Cold shock
GCK65_01890	COG3188	usher protein
GCK65_01895	COG3121	Chaperone
GCK65_01900	COG3539	Fimbrial protein
GCK65_01940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GCK65_01940	COG2885	chlorophyll binding
GCK65_01975	COG2916	Histone family protein nucleoid-structuring protein H-NS
GCK65_02005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCK65_02030	COG4974	Belongs to the 'phage' integrase family
GCK65_02035	COG0629	single-stranded DNA binding
GCK65_02040	COG2197	response regulator
GCK65_02045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GCK65_02055	COG3047	cAMP biosynthetic process
GCK65_02085	COG3135	benzoate transporter
GCK65_02090	COG1396	sequence-specific DNA binding
GCK65_02120	COG2926	Belongs to the UPF0265 family
GCK65_02130	COG3028	Belongs to the UPF0307 family
GCK65_02135	COG0312	modulator of DNA gyrase
GCK65_02140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GCK65_02145	COG5007	Belongs to the BolA IbaG family
GCK65_02155	COG2854	intermembrane phospholipid transfer
GCK65_02160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCK65_02165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCK65_02170	COG1127	ABC transporter
GCK65_02175	COG0517	IMP dehydrogenase activity
GCK65_02175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GCK65_02180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GCK65_02185	COG3117	lipopolysaccharide transmembrane transporter activity
GCK65_02190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GCK65_02195	COG1137	ATPase activity
GCK65_02200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GCK65_02210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_02215	COG1660	Displays ATPase and GTPase activities
GCK65_02220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_02225	COG3711	transcriptional antiterminator
GCK65_02225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_02240	COG3964	amidohydrolase
GCK65_02270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCK65_02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCK65_02285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GCK65_02290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GCK65_02295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GCK65_02300	COG0723	plastoquinol--plastocyanin reductase activity
GCK65_02305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GCK65_02310	COG2857	Cytochrome c1
GCK65_02315	COG0625	glutathione transferase activity
GCK65_02320	COG2969	positive regulation of protein catabolic process
GCK65_02325	COG2823	Periplasmic or secreted lipoprotein
GCK65_02330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCK65_02335	COG0792	nuclease activity
GCK65_02340	COG3107	peptidoglycan biosynthetic process
GCK65_02345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GCK65_02355	COG2001	Belongs to the MraZ family
GCK65_02360	COG0275	rRNA processing
GCK65_02365	COG3116	cell division
GCK65_02370	COG0768	penicillin binding
GCK65_02380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GCK65_02385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCK65_02390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GCK65_02395	COG0772	Belongs to the SEDS family
GCK65_02400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCK65_02405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCK65_02410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GCK65_02415	COG0849	cell division
GCK65_02420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GCK65_02425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GCK65_02435	COG0653	protein targeting
GCK65_02445	COG0494	nUDIX hydrolase
GCK65_02450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GCK65_02455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GCK65_02470	COG1459	type II secretion system
GCK65_02475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCK65_02505	COG2186	Transcriptional regulator
GCK65_02510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GCK65_02515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCK65_02520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCK65_02525	COG3447	MASE1 domain protein
GCK65_02525	COG5001	Diguanylate cyclase
GCK65_02525	COG5002	protein histidine kinase activity
GCK65_02535	COG0840	transmembrane signaling receptor activity
GCK65_02540	COG0840	transmembrane signaling receptor activity
GCK65_02545	COG1752	Esterase of the alpha-beta hydrolase superfamily
GCK65_02550	COG1049	propionate catabolic process, 2-methylcitrate cycle
GCK65_02555	COG2200	EAL domain
GCK65_02565	COG1280	lysine exporter protein (LysE YggA)
GCK65_02575	COG0523	cobalamin synthesis protein
GCK65_02580	COG0477	Major facilitator Superfamily
GCK65_02595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCK65_02600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GCK65_02640	COG3314	Sporulation integral membrane protein YlbJ
GCK65_02645	COG0835	chemotaxis
GCK65_02645	COG0784	Response regulator, receiver
GCK65_02655	COG1444	tRNA N-acetyltransferase activity
GCK65_02680	COG1803	Methylglyoxal synthase
GCK65_02695	COG0252	asparaginase activity
GCK65_02715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_02715	COG1263	PTS System
GCK65_02720	COG0366	Alpha amylase catalytic
GCK65_02725	COG0110	maltose O-acetyltransferase activity
GCK65_02730	COG1522	sequence-specific DNA binding
GCK65_02735	COG5006	permease, DMT superfamily
GCK65_02745	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_02750	COG1177	transmembrane transport
GCK65_02755	COG1176	ABC-type spermidine putrescine transport system, permease component I
GCK65_02760	COG3842	ATPase activity
GCK65_02765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GCK65_02770	COG0583	DNA-binding transcription factor activity
GCK65_02775	COG1757	Na H antiporter
GCK65_02815	COG0297	glycogen (starch) synthase activity
GCK65_02820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GCK65_02825	COG2813	Specifically methylates the guanine in position
GCK65_02830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCK65_02835	COG5001	Diguanylate cyclase
GCK65_02835	COG4251	negative regulation of phosphorylation
GCK65_02835	COG3706	GGDEF domain
GCK65_02835	COG2203	Gaf domain
GCK65_02845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCK65_02855	COG2995	paraquat-inducible protein a
GCK65_02860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCK65_02860	COG3008	intermembrane lipid transfer
GCK65_02865	COG3009	Protein conserved in bacteria
GCK65_02880	COG3240	lipase activity
GCK65_02885	COG3111	PFAM Bacterial OB fold (BOF) protein
GCK65_02895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GCK65_02900	COG1194	a g-specific adenine glycosylase
GCK65_02910	COG3267	Type II secretory pathway component ExeA
GCK65_02910	COG3409	Peptidoglycan-binding domain 1 protein
GCK65_02915	COG0617	tRNA 3'-terminal CCA addition
GCK65_02930	COG1346	cytolysis
GCK65_02935	COG1380	Effector of murein hydrolase LrgA
GCK65_02940	COG0583	DNA-binding transcription factor activity
GCK65_02970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GCK65_02975	COG0306	phosphate transporter
GCK65_02980	COG1392	Phosphate transport regulator
GCK65_02995	COG1560	Kdo2-lipid A biosynthetic process
GCK65_03000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GCK65_03000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GCK65_03005	COG1538	Outer membrane efflux protein
GCK65_03010	COG0494	nUDIX hydrolase
GCK65_03015	COG3151	Protein conserved in bacteria
GCK65_03025	COG3150	esterase
GCK65_03030	COG1051	belongs to the nudix hydrolase family
GCK65_03045	COG1566	PFAM secretion protein HlyD family protein
GCK65_03050	COG1289	transmembrane transporter activity
GCK65_03080	COG0583	DNA-binding transcription factor activity
GCK65_03125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCK65_03150	COG0204	Acyl-transferase
GCK65_03155	COG1842	Phage shock protein A
GCK65_03170	COG2827	Endonuclease containing a URI domain
GCK65_03180	COG2962	Rard protein
GCK65_03185	COG1573	uracil-dna glycosylase
GCK65_03190	COG0697	spore germination
GCK65_03195	COG0583	DNA-binding transcription factor activity
GCK65_03200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GCK65_03205	COG1121	(ABC) transporter
GCK65_03210	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GCK65_03230	COG0739	heme binding
GCK65_03240	COG3068	Protein conserved in bacteria
GCK65_03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GCK65_03265	COG1546	Belongs to the CinA family
GCK65_03270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GCK65_03280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GCK65_03285	COG0527	aspartate kinase activity
GCK65_03290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GCK65_03325	COG1686	Belongs to the peptidase S11 family
GCK65_03330	COG0586	Pfam SNARE associated Golgi protein
GCK65_03335	COG1253	flavin adenine dinucleotide binding
GCK65_03340	COG0525	valine-tRNA ligase activity
GCK65_03345	COG2927	DNA polymerase III (CHI subunit)
GCK65_03350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCK65_03355	COG0795	lipopolysaccharide-transporting ATPase activity
GCK65_03360	COG0795	lipopolysaccharide-transporting ATPase activity
GCK65_03375	COG0004	ammonium transporteR
GCK65_03380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCK65_03390	COG2165	general secretion pathway protein
GCK65_03395	COG0084	hydrolase, TatD family'
GCK65_03400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCK65_03410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GCK65_03415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GCK65_03420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GCK65_03425	COG0813	purine-nucleoside phosphorylase activity
GCK65_03430	COG5001	Diguanylate cyclase
GCK65_03430	COG3447	MASE1 domain protein
GCK65_03430	COG5002	protein histidine kinase activity
GCK65_03440	COG0560	Phosphoserine phosphatase
GCK65_03465	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GCK65_03475	COG0776	regulation of translation
GCK65_03490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCK65_03495	COG0735	belongs to the Fur family
GCK65_03520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GCK65_03525	COG0513	Belongs to the DEAD box helicase family
GCK65_03530	COG3022	response to hydroperoxide
GCK65_03545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GCK65_03550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GCK65_03555	COG0762	integral membrane protein
GCK65_03560	COG1872	DUF167
GCK65_03575	COG4166	transmembrane transport
GCK65_03595	COG1024	Enoyl-CoA hydratase
GCK65_03610	COG4221	oxidoreductase activity
GCK65_03615	COG0442	prolyl-tRNA aminoacylation
GCK65_03620	COG0840	transmembrane signaling receptor activity
GCK65_03625	COG0632	four-way junction helicase activity
GCK65_03630	COG2255	four-way junction helicase activity
GCK65_03640	COG1271	oxidase subunit
GCK65_03645	COG1294	oxidase, subunit
GCK65_03650	COG4890	Cyd operon protein YbgT
GCK65_03655	COG3790	cyd operon protein YbgE
GCK65_03660	COG0824	Thioesterase
GCK65_03665	COG0811	peptide transport
GCK65_03680	COG0823	Involved in the tonB-independent uptake of proteins
GCK65_03685	COG2885	chlorophyll binding
GCK65_03690	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GCK65_03765	COG0840	transmembrane signaling receptor activity
GCK65_03770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GCK65_03775	COG0676	glucose-6-phosphate 1-epimerase activity
GCK65_03780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCK65_03785	COG1640	4-alpha-glucanotransferase
GCK65_03790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GCK65_03810	COG1051	belongs to the nudix hydrolase family
GCK65_03815	COG2130	NADP-dependent
GCK65_03820	COG1764	response to oxidative stress
GCK65_03825	COG1846	Transcriptional regulator
GCK65_03855	COG0561	phosphatase activity
GCK65_03870	COG0733	neurotransmitter:sodium symporter activity
GCK65_03880	COG0733	neurotransmitter:sodium symporter activity
GCK65_03905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GCK65_03915	COG1794	racemase activity, acting on amino acids and derivatives
GCK65_03930	COG2731	YhcH YjgK YiaL family protein
GCK65_03940	COG0668	transmembrane transport
GCK65_03945	COG1376	ErfK ybiS ycfS ynhG family protein
GCK65_03950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCK65_03990	COG0583	DNA-binding transcription factor activity
GCK65_03995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GCK65_04005	COG0488	(ABC) transporter
GCK65_04010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GCK65_04010	COG0517	IMP dehydrogenase activity
GCK65_04015	COG1585	Membrane protein implicated in regulation of membrane protease activity
GCK65_04020	COG0330	HflC and HflK could
GCK65_04025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GCK65_04025	COG1648	precorrin-2 dehydrogenase activity
GCK65_04030	COG0175	sulfate reduction
GCK65_04035	COG2895	sulfate adenylyltransferase (ATP) activity
GCK65_04040	COG0471	metal ion transport
GCK65_04040	COG3273	potassium ion transport
GCK65_04045	COG0529	Catalyzes the synthesis of activated sulfate
GCK65_04095	COG1136	(ABC) transporter
GCK65_04110	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GCK65_04130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GCK65_04135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCK65_04140	COG0163	prenyltransferase activity
GCK65_04155	COG1131	(ABC) transporter
GCK65_04160	COG0842	Transport permease protein
GCK65_04165	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GCK65_04170	COG1924	4 iron, 4 sulfur cluster binding
GCK65_04190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GCK65_04195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GCK65_04200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GCK65_04210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCK65_04215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCK65_04220	COG1489	DNA binding
GCK65_04230	COG1643	Atp-dependent helicase
GCK65_04235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCK65_04240	COG0346	lactoylglutathione lyase activity
GCK65_04250	COG2076	Multidrug Resistance protein
GCK65_04260	COG3437	response regulator, receiver
GCK65_04260	COG0784	Response regulator, receiver
GCK65_04270	COG0671	phosphoesterase, PA-phosphatase related
GCK65_04285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GCK65_04290	COG0038	chloride channel
GCK65_04300	COG0316	Belongs to the HesB IscA family
GCK65_04325	COG1280	lysine exporter protein (LysE YggA)
GCK65_04335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GCK65_04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_04380	COG0745	RESPONSE REGULATOR receiver
GCK65_04385	COG3104	oligopeptide transport
GCK65_04390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCK65_04395	COG1555	photosystem II stabilization
GCK65_04405	COG2350	Protein conserved in bacteria
GCK65_04410	COG2917	probably involved in intracellular septation
GCK65_04415	COG0076	glutamate decarboxylase activity
GCK65_04420	COG1272	protein, Hemolysin III
GCK65_04425	COG0569	domain protein
GCK65_04425	COG2985	domain, Protein
GCK65_04435	COG0784	Response regulator, receiver
GCK65_04435	COG0835	chemotaxis
GCK65_04440	COG2755	lipolytic protein G-D-S-L family
GCK65_04445	COG4181	ATPase activity
GCK65_04450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GCK65_04455	COG1090	epimerase
GCK65_04460	COG2200	EAL domain
GCK65_04465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GCK65_04470	COG2234	aminopeptidase activity
GCK65_04470	COG4935	Belongs to the peptidase S8 family
GCK65_04475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GCK65_04480	COG3171	Protein conserved in bacteria
GCK65_04485	COG2066	Belongs to the glutaminase family
GCK65_04490	COG2897	thiosulfate sulfurtransferase activity
GCK65_04505	COG1132	(ABC) transporter
GCK65_04540	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GCK65_04545	COG3300	MHYT domain
GCK65_04545	COG5001	Diguanylate cyclase
GCK65_04565	COG4628	conserved protein (DUF2132)
GCK65_04570	COG0688	phosphatidylethanolamine metabolic process
GCK65_04575	COG1162	GTPase activity
GCK65_04580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GCK65_04630	COG1278	Cold shock
GCK65_04640	COG0840	transmembrane signaling receptor activity
GCK65_04645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCK65_04650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCK65_04700	COG0848	biopolymer transport protein
GCK65_04705	COG0811	peptide transport
GCK65_04710	COG0811	peptide transport
GCK65_04725	COG4174	ABC transporter (Permease)
GCK65_04730	COG4239	(ABC) transporter, permease
GCK65_04740	COG0444	Belongs to the ABC transporter superfamily
GCK65_04745	COG4608	Belongs to the ABC transporter superfamily
GCK65_04755	COG2195	Cleaves the N-terminal amino acid of tripeptides
GCK65_04765	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GCK65_04770	COG1073	alpha beta
GCK65_04785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GCK65_04820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCK65_04825	COG2313	pseudouridylate synthase activity
GCK65_04835	COG1858	cytochrome C peroxidase
GCK65_04870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCK65_04875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCK65_04900	COG2986	histidine ammonia-lyase
GCK65_04925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCK65_04935	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_04940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCK65_04950	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCK65_04960	COG2966	Psort location CytoplasmicMembrane, score
GCK65_04965	COG3610	response to peptide
GCK65_04985	COG4175	Glycine betaine
GCK65_04990	COG4176	ABC-type proline glycine betaine transport system permease component
GCK65_04995	COG2113	Glycine betaine
GCK65_05000	COG0175	sulfate reduction
GCK65_05005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCK65_05010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GCK65_05015	COG0384	phenazine biosynthesis protein PhzF
GCK65_05020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GCK65_05035	COG0786	glutamate:sodium symporter activity
GCK65_05040	COG0252	asparaginase activity
GCK65_05045	COG3139	Protein of unknown function (DUF1315)
GCK65_05065	COG0616	signal peptide processing
GCK65_05070	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCK65_05070	COG1902	pentaerythritol trinitrate reductase activity
GCK65_05075	COG0778	Nitroreductase
GCK65_05090	COG2264	protein methyltransferase activity
GCK65_05095	COG0604	alcohol dehydrogenase
GCK65_05100	COG0583	DNA-binding transcription factor activity
GCK65_05105	COG1263	PTS System
GCK65_05105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_05105	COG2190	(PTS) system
GCK65_05110	COG4145	pantothenate transmembrane transporter activity
GCK65_05120	COG0439	Biotin carboxylase
GCK65_05125	COG0511	ligase activity, forming carbon-carbon bonds
GCK65_05130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GCK65_05135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCK65_05165	COG3381	protein complex oligomerization
GCK65_05175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GCK65_05185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCK65_05190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCK65_05190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCK65_05210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GCK65_05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCK65_05220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GCK65_05225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GCK65_05230	COG4172	Belongs to the ABC transporter superfamily
GCK65_05240	COG0601	transmembrane transport
GCK65_05250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCK65_05255	COG0142	geranyltranstransferase activity
GCK65_05260	COG1722	exodeoxyribonuclease VII activity
GCK65_05265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCK65_05270	COG1360	Flagellar Motor Protein
GCK65_05285	COG1534	Rna-binding protein
GCK65_05290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GCK65_05300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GCK65_05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GCK65_05310	COG0149	triose-phosphate isomerase activity
GCK65_05315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GCK65_05330	COG0779	Required for maturation of 30S ribosomal subunits
GCK65_05335	COG0195	Participates in both transcription termination and antitermination
GCK65_05340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GCK65_05345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GCK65_05350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GCK65_05355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GCK65_05360	COG1185	polyribonucleotide nucleotidyltransferase activity
GCK65_05365	COG2211	Major facilitator Superfamily
GCK65_05375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GCK65_05385	COG0114	fumarate hydratase activity
GCK65_05395	COG1966	Carbon starvation protein
GCK65_05400	COG3279	Response regulator of the LytR AlgR family
GCK65_05405	COG3275	phosphorelay sensor kinase activity
GCK65_05470	COG0312	modulator of DNA gyrase
GCK65_05475	COG0312	modulator of DNA gyrase
GCK65_05485	COG4974	Belongs to the 'phage' integrase family
GCK65_05490	COG1970	mechanosensitive ion channel activity
GCK65_05495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCK65_05505	COG0789	Transcriptional regulator
GCK65_05520	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCK65_05525	COG3545	Serine hydrolase
GCK65_05535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GCK65_05545	COG0321	lipoyl(octanoyl) transferase activity
GCK65_05550	COG2921	Belongs to the UPF0250 family
GCK65_05555	COG1686	Belongs to the peptidase S11 family
GCK65_05565	COG2951	lytic endotransglycosylase activity
GCK65_05570	COG0772	Belongs to the SEDS family
GCK65_05575	COG0768	penicillin binding
GCK65_05580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GCK65_05585	COG0799	negative regulation of ribosome biogenesis
GCK65_05590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GCK65_05610	COG0495	leucyl-tRNA aminoacylation
GCK65_05615	COG2888	peptidyl-tyrosine sulfation
GCK65_05620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCK65_05625	COG4535	Mg2 and Co2 transporter CorC
GCK65_05630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GCK65_05635	COG1702	phosphate starvation-inducible protein PhoH
GCK65_05640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCK65_05645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCK65_05650	COG1335	isochorismatase
GCK65_05660	COG3706	GGDEF domain
GCK65_05675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCK65_05685	COG3706	GGDEF domain
GCK65_05695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCK65_05705	COG3647	Membrane
GCK65_05710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GCK65_05720	COG0516	GMP reductase activity
GCK65_05730	COG0642	Histidine kinase
GCK65_05765	COG4106	trans-aconitate 2-methyltransferase activity
GCK65_05770	COG3214	Protein conserved in bacteria
GCK65_05795	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GCK65_05800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GCK65_05805	COG1053	succinate dehydrogenase
GCK65_05815	COG0584	glycerophosphoryl diester phosphodiesterase
GCK65_05820	COG1511	domain protein
GCK65_05820	COG3264	Mechanosensitive ion channel
GCK65_05830	COG0739	heme binding
GCK65_05845	COG0583	DNA-binding transcription factor activity
GCK65_05865	COG0583	DNA-binding transcription factor activity
GCK65_05870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GCK65_05900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCK65_05905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GCK65_05915	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GCK65_05925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GCK65_05935	COG0180	Tryptophanyl-tRNA synthetase
GCK65_05950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCK65_05960	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_06000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCK65_06010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_06010	COG0674	pyruvate-flavodoxin oxidoreductase activity
GCK65_06010	COG1013	pyruvate-flavodoxin oxidoreductase activity
GCK65_06010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GCK65_06020	COG0366	Alpha amylase catalytic
GCK65_06030	COG3097	Belongs to the UPF0267 family
GCK65_06040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GCK65_06050	COG0471	metal ion transport
GCK65_06050	COG0490	domain, Protein
GCK65_06095	COG0012	GTP binding
GCK65_06100	COG0193	aminoacyl-tRNA hydrolase activity
GCK65_06105	COG0737	Belongs to the 5'-nucleotidase family
GCK65_06110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GCK65_06120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GCK65_06125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GCK65_06130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GCK65_06135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GCK65_06140	COG2890	protein-(glutamine-N5) methyltransferase activity
GCK65_06150	COG2912	Transglutaminase-like superfamily
GCK65_06155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GCK65_06160	COG1301	dicarboxylic acid transport
GCK65_06170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GCK65_06185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCK65_06190	COG1115	amino acid carrier protein
GCK65_06205	COG0714	Associated with various cellular activities
GCK65_06215	COG3104	oligopeptide transport
GCK65_06220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GCK65_06225	COG1678	Uncharacterized ACR, COG1678
GCK65_06235	COG0189	ligase activity
GCK65_06240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GCK65_06250	COG3091	SprT-like family
GCK65_06260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GCK65_06285	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GCK65_06290	COG0739	heme binding
GCK65_06295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GCK65_06300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GCK65_06300	COG3408	Glycogen debranching enzyme
GCK65_06310	COG1881	PFAM PEBP family protein
GCK65_06315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GCK65_06320	COG0583	DNA-binding transcription factor activity
GCK65_06330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GCK65_06340	COG0583	DNA-binding transcription factor activity
GCK65_06345	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_06350	COG0616	signal peptide processing
GCK65_06355	COG3724	N-succinylarginine dihydrolase activity
GCK65_06375	COG0840	transmembrane signaling receptor activity
GCK65_06385	COG2971	BadF BadG BcrA BcrD
GCK65_06395	COG4608	Belongs to the ABC transporter superfamily
GCK65_06400	COG0444	Belongs to the ABC transporter superfamily
GCK65_06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCK65_06410	COG0601	transmembrane transport
GCK65_06415	COG4166	transmembrane transport
GCK65_06420	COG0784	Response regulator, receiver
GCK65_06420	COG2205	protein histidine kinase activity
GCK65_06450	COG3220	belongs to the UPF0276 family
GCK65_06480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCK65_06485	COG1289	transmembrane transporter activity
GCK65_06490	COG0303	'Molybdopterin
GCK65_06495	COG0746	molybdenum cofactor guanylyltransferase activity
GCK65_06505	COG4662	Binding-protein-dependent transport system inner membrane component
GCK65_06515	COG2204	response regulator
GCK65_06520	COG3852	Histidine kinase
GCK65_06525	COG1910	domain protein
GCK65_06530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCK65_06565	COG3383	formate dehydrogenase (NAD+) activity
GCK65_06565	COG3383	formate dehydrogenase (NAD+) activity
GCK65_06570	COG0437	4 iron, 4 sulfur cluster binding
GCK65_06585	COG0281	malic enzyme
GCK65_06605	COG2706	6-phosphogluconolactonase activity
GCK65_06615	COG1196	nuclear chromosome segregation
GCK65_06615	COG3264	Mechanosensitive ion channel
GCK65_06620	COG0469	pyruvate kinase activity
GCK65_06635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCK65_06635	COG4651	solute:proton antiporter activity
GCK65_06645	COG2974	May be involved in recombination
GCK65_06655	COG0420	3'-5' exonuclease activity
GCK65_06660	COG0419	ATPase involved in DNA repair
GCK65_06670	COG3038	cytochrome b561
GCK65_06685	COG2190	(PTS) system
GCK65_06695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_06700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GCK65_06705	COG0542	response to heat
GCK65_06720	COG1720	tRNA m6t6A37 methyltransferase activity
GCK65_06740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GCK65_06745	COG4988	ABC transporter
GCK65_06760	COG0745	RESPONSE REGULATOR receiver
GCK65_06770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GCK65_06785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GCK65_06790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GCK65_06805	COG0083	homoserine kinase activity
GCK65_06810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GCK65_06815	COG4319	ketosteroid isomerase
GCK65_06830	COG0488	(ABC) transporter
GCK65_06845	COG0813	purine-nucleoside phosphorylase activity
GCK65_06860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_06860	COG2205	protein histidine kinase activity
GCK65_06865	COG3384	dioxygenase
GCK65_06875	COG1283	sodium-dependent phosphate transmembrane transporter activity
GCK65_06885	COG0531	amino acid
GCK65_06890	COG0531	amino acid
GCK65_06905	COG1396	sequence-specific DNA binding
GCK65_06905	COG1917	Cupin 2, conserved barrel domain protein
GCK65_06910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCK65_06930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCK65_06935	COG2375	cellular response to nickel ion
GCK65_06945	COG0577	efflux transmembrane transporter activity
GCK65_06945	COG1136	(ABC) transporter
GCK65_06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_06960	COG1227	inorganic diphosphatase activity
GCK65_06965	COG0497	DNA recombination
GCK65_06970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GCK65_06975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCK65_06980	COG0443	Heat shock 70 kDa protein
GCK65_06985	COG0484	heat shock protein binding
GCK65_07015	COG1285	pathogenesis
GCK65_07030	COG0640	Transcriptional regulator
GCK65_07040	COG2391	methyltransferase activity
GCK65_07060	COG0095	Lipoate-protein ligase
GCK65_07080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCK65_07085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_07105	COG0708	Exodeoxyribonuclease III
GCK65_07120	COG2211	Major facilitator Superfamily
GCK65_07165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCK65_07170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCK65_07175	COG1845	cytochrome c oxidase, subunit III
GCK65_07180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GCK65_07185	COG0109	protoheme IX farnesyltransferase activity
GCK65_07190	COG2814	Major facilitator Superfamily
GCK65_07205	COG2175	clavaminate synthase activity
GCK65_07215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GCK65_07220	COG4521	taurine ABC transporter
GCK65_07230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCK65_07315	COG0159	tryptophan synthase activity
GCK65_07320	COG0133	tryptophan synthase activity
GCK65_07325	COG0134	indole-3-glycerol-phosphate synthase activity
GCK65_07325	COG0135	phosphoribosylanthranilate isomerase activity
GCK65_07330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCK65_07335	COG0512	Glutamine amidotransferase of anthranilate synthase
GCK65_07335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCK65_07340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GCK65_07350	COG0009	L-threonylcarbamoyladenylate synthase
GCK65_07360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GCK65_07370	COG1946	Acyl-CoA thioesterase
GCK65_07385	COG1309	transcriptional regulator
GCK65_07390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_07395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCK65_07410	COG1091	dTDP-4-dehydrorhamnose reductase activity
GCK65_07430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCK65_07435	COG2030	dehydratase
GCK65_07445	COG2244	polysaccharide biosynthetic process
GCK65_07465	COG1216	Glycosyl transferase, family 2
GCK65_07470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GCK65_07485	COG3132	Protein of unknown function, DUF480
GCK65_07525	COG1278	Cold shock
GCK65_07560	COG1349	DNA-binding transcription factor activity
GCK65_07565	COG1882	Formate acetyltransferase
GCK65_07570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCK65_07575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCK65_07605	COG0622	Phosphoesterase
GCK65_07620	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GCK65_07625	COG0835	chemotaxis
GCK65_07625	COG0784	Response regulator, receiver
GCK65_07630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GCK65_07635	COG1815	bacterial-type flagellum-dependent cell motility
GCK65_07655	COG4787	bacterial-type flagellum-dependent cell motility
GCK65_07665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GCK65_07670	COG1706	bacterial-type flagellum-dependent cell motility
GCK65_07680	COG1256	bacterial-type flagellum assembly
GCK65_07690	COG2239	Acts as a magnesium transporter
GCK65_07700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GCK65_07705	COG2716	regulation of RNA biosynthetic process
GCK65_07730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GCK65_07735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GCK65_07740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GCK65_07745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GCK65_07765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GCK65_07775	COG0590	tRNA wobble adenosine to inosine editing
GCK65_07780	COG0573	inorganic phosphate transmembrane transporter activity
GCK65_07785	COG0581	inorganic phosphate transmembrane transporter activity
GCK65_07790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GCK65_07795	COG0704	Plays a role in the regulation of phosphate uptake
GCK65_07800	COG1253	flavin adenine dinucleotide binding
GCK65_07815	COG0531	amino acid
GCK65_07830	COG1126	abc transporter atp-binding protein
GCK65_07835	COG0765	amino acid transport
GCK65_07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_07850	COG2271	Major facilitator Superfamily
GCK65_07865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCK65_07890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GCK65_07895	COG0477	Major facilitator Superfamily
GCK65_07900	COG0123	including yeast histone deacetylase and acetoin utilization protein
GCK65_07910	COG1199	ATP-dependent helicase activity
GCK65_07925	COG1448	Aminotransferase
GCK65_07930	COG0433	COG0433 Predicted ATPase
GCK65_07945	COG0658	competence protein
GCK65_07945	COG2333	competence protein COMEC
GCK65_07955	COG1663	tetraacyldisaccharide 4'-kinase activity
GCK65_07960	COG2835	tetraacyldisaccharide 4'-kinase activity
GCK65_07965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GCK65_07970	COG2197	response regulator
GCK65_07975	COG0322	excinuclease ABC activity
GCK65_08130	COG4695	Portal protein
GCK65_08195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCK65_08215	COG4974	Belongs to the 'phage' integrase family
GCK65_08260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GCK65_08265	COG0437	4 iron, 4 sulfur cluster binding
GCK65_08270	COG3301	Polysulphide reductase, NrfD
GCK65_08275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCK65_08285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCK65_08305	COG2203	Gaf domain
GCK65_08305	COG2199	diguanylate cyclase activity
GCK65_08335	COG2119	membrane
GCK65_08340	COG0023	Translation Initiation Factor
GCK65_08380	COG2205	protein histidine kinase activity
GCK65_08380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_08390	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GCK65_08400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCK65_08405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GCK65_08410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCK65_08415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GCK65_08420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GCK65_08430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GCK65_08435	COG0505	Belongs to the CarA family
GCK65_08440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GCK65_08445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCK65_08475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCK65_08480	COG0513	Belongs to the DEAD box helicase family
GCK65_08490	COG4104	PAAR repeat-containing protein
GCK65_08505	COG0789	Transcriptional regulator
GCK65_08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_08525	COG0765	amino acid transport
GCK65_08530	COG1126	abc transporter atp-binding protein
GCK65_08535	COG0493	'glutamate synthase
GCK65_08540	COG0067	glutamate synthase
GCK65_08540	COG0069	glutamate synthase activity
GCK65_08540	COG0070	glutamate synthase
GCK65_08545	COG1242	4 iron, 4 sulfur cluster binding
GCK65_08600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GCK65_08605	COG0574	Belongs to the PEP-utilizing enzyme family
GCK65_08605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCK65_08640	COG3038	cytochrome b561
GCK65_08655	COG1464	Belongs to the NlpA lipoprotein family
GCK65_08660	COG0671	phosphoesterase, PA-phosphatase related
GCK65_08665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCK65_08670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCK65_08680	COG0101	tRNA pseudouridine synthase activity
GCK65_08685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GCK65_08690	COG0285	dihydrofolate synthase activity
GCK65_08695	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GCK65_08700	COG2920	part of a sulfur-relay system
GCK65_08705	COG1289	transmembrane transporter activity
GCK65_08710	COG0670	Belongs to the BI1 family
GCK65_08730	COG2194	sulfuric ester hydrolase activity
GCK65_08740	COG0392	lysyltransferase activity
GCK65_08740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GCK65_08750	COG0840	transmembrane signaling receptor activity
GCK65_08755	COG2203	Gaf domain
GCK65_08755	COG2199	diguanylate cyclase activity
GCK65_08760	COG0564	pseudouridine synthase activity
GCK65_08775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GCK65_08785	COG0625	glutathione transferase activity
GCK65_08795	COG0625	glutathione transferase activity
GCK65_08805	COG0367	asparagine synthase
GCK65_08820	COG0647	UMP catabolic process
GCK65_08825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GCK65_08830	COG1902	pentaerythritol trinitrate reductase activity
GCK65_08835	COG1253	flavin adenine dinucleotide binding
GCK65_08845	COG0247	lactate metabolic process
GCK65_08845	COG0277	FAD linked oxidase domain protein
GCK65_08855	COG2050	protein possibly involved in aromatic compounds catabolism
GCK65_08865	COG2056	Na+-H+ antiporter family
GCK65_08870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCK65_08885	COG0346	lactoylglutathione lyase activity
GCK65_08890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GCK65_08895	COG4660	Part of a membrane complex involved in electron transport
GCK65_08900	COG4659	FMN binding
GCK65_08905	COG4658	electron transport chain
GCK65_08915	COG2878	Part of a membrane complex involved in electron transport
GCK65_08920	COG4657	Part of a membrane complex involved in electron transport
GCK65_08925	COG0697	spore germination
GCK65_08945	COG2932	Transcriptional regulator
GCK65_09055	COG0640	Transcriptional regulator
GCK65_09065	COG4373	Mu-like prophage FluMu protein gp28
GCK65_09070	COG4383	Mu-like prophage protein gp29
GCK65_09095	COG4388	Caudovirus prohead serine protease
GCK65_09100	COG4397	Mu-like prophage major head subunit gpT
GCK65_09195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GCK65_09200	COG1288	antiporter activity
GCK65_09205	COG0436	Aminotransferase
GCK65_09215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCK65_09220	COG2027	D-alanyl-D-alanine carboxypeptidase
GCK65_09225	COG1061	Type III restriction enzyme res subunit
GCK65_09230	COG1566	PFAM secretion protein HlyD family protein
GCK65_09240	COG1966	Carbon starvation protein
GCK65_09245	COG3279	Response regulator of the LytR AlgR family
GCK65_09250	COG3275	phosphorelay sensor kinase activity
GCK65_09255	COG2199	diguanylate cyclase activity
GCK65_09255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCK65_09260	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_09260	COG1454	alcohol dehydrogenase
GCK65_09270	COG2095	MarC family integral membrane protein
GCK65_09280	COG0601	transmembrane transport
GCK65_09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCK65_09300	COG0861	Integral membrane protein TerC family
GCK65_09305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCK65_09315	COG1301	dicarboxylic acid transport
GCK65_09330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GCK65_09345	COG0537	adenosine 5'-monophosphoramidase activity
GCK65_09380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCK65_09385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCK65_09395	COG2354	Protein conserved in bacteria
GCK65_09410	COG2233	PERMEase
GCK65_09415	COG3150	esterase
GCK65_09420	COG1252	NADH dehydrogenase
GCK65_09440	COG0393	Putative heavy-metal-binding
GCK65_09450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GCK65_09450	COG1648	precorrin-2 dehydrogenase activity
GCK65_09470	COG4667	esterase of the alpha-beta hydrolase superfamily
GCK65_09475	COG1619	proteins homologs of microcin C7 resistance protein MccF
GCK65_09480	COG1368	sulfuric ester hydrolase activity
GCK65_09490	COG0527	aspartate kinase activity
GCK65_09495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCK65_09495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GCK65_09500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCK65_09525	COG0596	Alpha beta hydrolase
GCK65_09530	COG0346	lactoylglutathione lyase activity
GCK65_09540	COG0583	DNA-binding transcription factor activity
GCK65_09545	COG1620	l-lactate permease
GCK65_09550	COG0247	lactate metabolic process
GCK65_09555	COG1139	Iron-sulfur cluster binding protein
GCK65_09595	COG0577	efflux transmembrane transporter activity
GCK65_09600	COG1136	(ABC) transporter
GCK65_09610	COG2814	Major facilitator Superfamily
GCK65_09630	COG0672	)-iron permease
GCK65_09660	COG0659	secondary active sulfate transmembrane transporter activity
GCK65_09770	COG3311	Transcriptional regulator
GCK65_09780	COG1401	restriction endodeoxyribonuclease activity
GCK65_09830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCK65_09835	COG1757	Na H antiporter
GCK65_09885	COG0500	methyltransferase
GCK65_09895	COG0582	viral genome integration into host DNA
GCK65_09910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCK65_09915	COG0840	transmembrane signaling receptor activity
GCK65_09925	COG2201	protein-glutamate methylesterase activity
GCK65_09935	COG0835	chemotaxis
GCK65_09940	COG3290	protein histidine kinase activity
GCK65_09940	COG0840	transmembrane signaling receptor activity
GCK65_09945	COG0643	Histidine kinase
GCK65_09945	COG2198	Histidine kinase
GCK65_09955	COG0745	RESPONSE REGULATOR receiver
GCK65_09960	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GCK65_09965	COG0437	4 iron, 4 sulfur cluster binding
GCK65_09970	COG5557	Pfam Polysulphide reductase, NrfD
GCK65_09975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GCK65_09980	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GCK65_09985	COG1773	rubredoxin
GCK65_10000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCK65_10005	COG0444	Belongs to the ABC transporter superfamily
GCK65_10010	COG3842	ATPase activity
GCK65_10015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCK65_10020	COG0375	protein maturation
GCK65_10025	COG0309	Hydrogenase expression formation protein (HypE)
GCK65_10035	COG0298	carbon dioxide binding
GCK65_10040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GCK65_10050	COG1921	L-seryl-tRNASec selenium transferase activity
GCK65_10060	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GCK65_10070	COG3260	NADH ubiquinone oxidoreductase 20
GCK65_10075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_10080	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GCK65_10080	COG3261	NADH dehydrogenase
GCK65_10085	COG0650	Formate hydrogenlyase subunit 4
GCK65_10090	COG0651	ATP synthesis coupled electron transport
GCK65_10095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_10100	COG3158	transport of potassium into the cell
GCK65_10110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_10135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GCK65_10145	COG0326	Molecular chaperone. Has ATPase activity
GCK65_10155	COG0563	adenylate kinase activity
GCK65_10160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GCK65_10165	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GCK65_10170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCK65_10185	COG3300	MHYT domain
GCK65_10185	COG5001	Diguanylate cyclase
GCK65_10190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GCK65_10210	COG1021	2,3-dihydroxybenzoate-AMP ligase
GCK65_10215	COG1535	isochorismatase
GCK65_10215	COG3433	isochorismatase activity
GCK65_10220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GCK65_10225	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_10235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GCK65_10240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GCK65_10250	COG1120	ATPase activity
GCK65_10255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCK65_10260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCK65_10265	COG4771	TonB-dependent receptor
GCK65_10310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GCK65_10315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GCK65_10320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCK65_10335	COG1570	exodeoxyribonuclease VII activity
GCK65_10340	COG0697	spore germination
GCK65_10360	COG3158	transport of potassium into the cell
GCK65_10365	COG0517	IMP dehydrogenase activity
GCK65_10365	COG0516	GMP reductase activity
GCK65_10370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GCK65_10370	COG0519	Catalyzes the synthesis of GMP from XMP
GCK65_10410	COG2062	phosphohistidine phosphatase, SixA
GCK65_10420	COG0697	spore germination
GCK65_10425	COG4166	transmembrane transport
GCK65_10430	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCK65_10435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GCK65_10445	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCK65_10450	COG1136	(ABC) transporter
GCK65_10455	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCK65_10460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GCK65_10475	COG0544	peptidyl-prolyl cis-trans isomerase activity
GCK65_10480	COG0740	serine-type endopeptidase activity
GCK65_10485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GCK65_10490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCK65_10495	COG0776	regulation of translation
GCK65_10500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCK65_10505	COG0488	(ABC) transporter
GCK65_10510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCK65_10515	COG3162	membrane
GCK65_10530	COG1024	Enoyl-CoA hydratase
GCK65_10570	COG1115	amino acid carrier protein
GCK65_10580	COG3228	Belongs to the MtfA family
GCK65_10585	COG1584	GPR1 FUN34 yaaH family protein
GCK65_10620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GCK65_10625	COG1960	acyl-CoA dehydrogenase activity
GCK65_10635	COG1960	acyl-CoA dehydrogenase activity
GCK65_10640	COG1024	Enoyl-CoA hydratase
GCK65_10645	COG1024	Enoyl-CoA hydratase
GCK65_10655	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_10665	COG0730	response to heat
GCK65_10675	COG0583	DNA-binding transcription factor activity
GCK65_10680	COG0667	Aldo Keto reductase
GCK65_10695	COG3706	GGDEF domain
GCK65_10700	COG0583	DNA-binding transcription factor activity
GCK65_10705	COG2723	6-phospho-beta-galactosidase activity
GCK65_10710	COG5001	Diguanylate cyclase
GCK65_10710	COG3300	MHYT domain
GCK65_10720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCK65_10730	COG0583	DNA-binding transcription factor activity
GCK65_10735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GCK65_10740	COG0673	inositol 2-dehydrogenase activity
GCK65_10745	COG0583	DNA-binding transcription factor activity
GCK65_10755	COG1560	Kdo2-lipid A biosynthetic process
GCK65_10760	COG1560	Kdo2-lipid A biosynthetic process
GCK65_10785	COG0417	DNA replication proofreading
GCK65_10815	COG0534	Mate efflux family protein
GCK65_10825	COG0307	riboflavin synthase, alpha
GCK65_10835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCK65_10840	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GCK65_10845	COG0697	spore germination
GCK65_10850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GCK65_10890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCK65_10895	COG3099	Belongs to the UPF0263 family
GCK65_10900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GCK65_10905	COG2894	cell division
GCK65_10910	COG0850	regulation of cytokinetic process
GCK65_10915	COG3100	YcgL domain-containing protein
GCK65_10920	COG2951	lytic endotransglycosylase activity
GCK65_10925	COG1760	l-serine dehydratase
GCK65_10935	COG1760	l-serine dehydratase
GCK65_10940	COG3123	guanosine phosphorylase activity
GCK65_10960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GCK65_10965	COG2067	long-chain fatty acid transport protein
GCK65_10980	COG1595	DNA-templated transcription, initiation
GCK65_11010	COG0714	Associated with various cellular activities
GCK65_11015	COG0183	Belongs to the thiolase family
GCK65_11020	COG1024	Enoyl-CoA hydratase
GCK65_11020	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCK65_11040	COG3829	transcription factor binding
GCK65_11045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GCK65_11050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GCK65_11055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCK65_11065	COG0549	Belongs to the carbamate kinase family
GCK65_11070	COG0697	spore germination
GCK65_11075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GCK65_11075	COG3608	succinylglutamate desuccinylase aspartoacylase
GCK65_11080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GCK65_11085	COG2068	MobA-Related Protein
GCK65_11090	COG0493	'glutamate synthase
GCK65_11090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_11095	COG0402	S-adenosylhomocysteine deaminase activity
GCK65_11100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GCK65_11105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GCK65_11105	COG2080	2 iron, 2 sulfur cluster binding
GCK65_11110	COG2233	PERMEase
GCK65_11115	COG0402	S-adenosylhomocysteine deaminase activity
GCK65_11120	COG2252	PERMEase
GCK65_11125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GCK65_11130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GCK65_11135	COG2080	2 iron, 2 sulfur cluster binding
GCK65_11145	COG3134	Outer membrane lipoprotein
GCK65_11155	COG1288	antiporter activity
GCK65_11160	COG0318	PFAM AMP-dependent synthetase and ligase
GCK65_11170	COG0140	phosphoribosyl-ATP diphosphatase activity
GCK65_11170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GCK65_11175	COG0107	imidazoleglycerol-phosphate synthase activity
GCK65_11180	COG2198	Histidine kinase
GCK65_11180	COG2205	protein histidine kinase activity
GCK65_11180	COG0784	Response regulator, receiver
GCK65_11185	COG2199	diguanylate cyclase activity
GCK65_11190	COG3437	response regulator, receiver
GCK65_11195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GCK65_11200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GCK65_11205	COG0131	Imidazoleglycerol-phosphate dehydratase
GCK65_11205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCK65_11210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCK65_11215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GCK65_11220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GCK65_11230	COG1199	ATP-dependent helicase activity
GCK65_11240	COG1214	PFAM Peptidase M22, glycoprotease
GCK65_11250	COG0596	Alpha beta hydrolase
GCK65_11250	COG2226	methyltransferase
GCK65_11250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCK65_11255	COG0318	PFAM AMP-dependent synthetase and ligase
GCK65_11260	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GCK65_11430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCK65_11435	COG2832	Protein of unknown function (DUF454)
GCK65_11440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GCK65_11450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GCK65_11475	COG0517	IMP dehydrogenase activity
GCK65_11475	COG0617	tRNA 3'-terminal CCA addition
GCK65_11475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GCK65_11480	COG1643	Atp-dependent helicase
GCK65_11490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GCK65_11500	COG3437	response regulator, receiver
GCK65_11505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCK65_11510	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GCK65_11515	COG0709	Synthesizes selenophosphate from selenide and ATP
GCK65_11530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCK65_11535	COG0840	transmembrane signaling receptor activity
GCK65_11540	COG1254	Belongs to the acylphosphatase family
GCK65_11545	COG0625	glutathione transferase activity
GCK65_11550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCK65_11550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCK65_11555	COG0489	protein tyrosine kinase activity
GCK65_11560	COG0572	uridine kinase
GCK65_11565	COG0717	Belongs to the dCTP deaminase family
GCK65_11575	COG0306	phosphate transporter
GCK65_11580	COG1530	ribonuclease E activity
GCK65_11585	COG0564	pseudouridine synthase activity
GCK65_11590	COG0546	phosphoglycolate phosphatase activity
GCK65_11595	COG0424	maF-like protein
GCK65_11600	COG2814	Major facilitator Superfamily
GCK65_11615	COG1399	metal-binding, possibly nucleic acid-binding protein
GCK65_11620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GCK65_11625	COG0416	fatty acid biosynthetic process
GCK65_11630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GCK65_11640	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_11645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCK65_11655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GCK65_11660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GCK65_11665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GCK65_11670	COG0470	DNA polymerase III
GCK65_11675	COG0084	hydrolase, TatD family'
GCK65_11690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCK65_11690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GCK65_11695	COG3008	intermembrane lipid transfer
GCK65_11700	COG2995	paraquat-inducible protein a
GCK65_11710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GCK65_11715	COG0372	Belongs to the citrate synthase family
GCK65_11760	COG4221	oxidoreductase activity
GCK65_11770	COG3141	response to X-ray
GCK65_11780	COG1067	ATP-dependent peptidase activity
GCK65_11785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCK65_11800	COG0488	(ABC) transporter
GCK65_11810	COG0116	Belongs to the methyltransferase superfamily
GCK65_11810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCK65_11825	COG0167	dihydroorotate dehydrogenase activity
GCK65_11830	COG2902	Dehydrogenase
GCK65_11840	COG0308	aminopeptidase N
GCK65_11850	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GCK65_11855	COG1956	GAF domain-containing protein
GCK65_11865	COG3278	Belongs to the heme-copper respiratory oxidase family
GCK65_11880	COG2010	Cytochrome c
GCK65_11905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCK65_11910	COG0589	response to stress
GCK65_11915	COG0037	tRNA processing
GCK65_11935	COG1869	D-ribose catabolic process
GCK65_11940	COG1129	ABC transporter
GCK65_11945	COG1172	Belongs to the binding-protein-dependent transport system permease family
GCK65_11950	COG1879	ABC-type sugar transport system periplasmic component
GCK65_11955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCK65_11960	COG1609	Transcriptional regulator
GCK65_11965	COG2199	diguanylate cyclase activity
GCK65_11995	COG0776	regulation of translation
GCK65_12000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCK65_12000	COG0072	phenylalanine-tRNA ligase activity
GCK65_12005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GCK65_12010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GCK65_12015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GCK65_12020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GCK65_12025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GCK65_12045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCK65_12055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCK65_12060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCK65_12065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCK65_12070	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GCK65_12075	COG3313	Fe-S protein
GCK65_12080	COG2942	2-epimerase
GCK65_12085	COG3716	PTS system mannose fructose sorbose family IID component
GCK65_12090	COG3715	PTS system
GCK65_12095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_12095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_12110	COG1609	Transcriptional regulator
GCK65_12115	COG2140	Oxalate decarboxylase
GCK65_12120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_12120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_12120	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GCK65_12125	COG1105	Belongs to the carbohydrate kinase PfkB family
GCK65_12130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_12130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_12135	COG1609	Transcriptional regulator
GCK65_12140	COG0814	amino acid
GCK65_12150	COG5654	RES domain protein
GCK65_12155	COG0513	Belongs to the DEAD box helicase family
GCK65_12165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GCK65_12170	COG2890	protein-(glutamine-N5) methyltransferase activity
GCK65_12175	COG2840	Smr protein MutS2
GCK65_12215	COG2824	Alkylphosphonate utilization operon protein PhnA
GCK65_12230	COG0384	phenazine biosynthesis protein PhzF
GCK65_12260	COG0242	peptide deformylase activity
GCK65_12280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GCK65_12285	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GCK65_12295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCK65_12300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GCK65_12310	COG0205	6-phosphofructokinase activity
GCK65_12315	COG1473	amidohydrolase
GCK65_12320	COG1011	Hydrolase
GCK65_12325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCK65_12370	COG3593	DNA synthesis involved in DNA repair
GCK65_12380	COG0697	spore germination
GCK65_12385	COG0583	DNA-binding transcription factor activity
GCK65_12390	COG0730	response to heat
GCK65_12395	COG3148	PFAM DTW domain containing protein
GCK65_12405	COG1181	Belongs to the D-alanine--D-alanine ligase family
GCK65_12420	COG0386	Belongs to the glutathione peroxidase family
GCK65_12425	COG0513	Belongs to the DEAD box helicase family
GCK65_12430	COG0456	acetyltransferase
GCK65_12440	COG1742	UPF0060 membrane protein
GCK65_12475	COG2329	Antibiotic biosynthesis monooxygenase
GCK65_12480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GCK65_12500	COG3243	poly(R)-hydroxyalkanoic acid synthase
GCK65_12510	COG2501	S4 domain
GCK65_12520	COG1132	(ABC) transporter
GCK65_12530	COG1132	(ABC) transporter
GCK65_12540	COG3118	belongs to the thioredoxin family
GCK65_12545	COG0471	metal ion transport
GCK65_12550	COG0058	SHG alpha-glucan phosphorylase activity
GCK65_12590	COG0814	amino acid
GCK65_12595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GCK65_12600	COG0514	ATP-dependent DNA helicase (RecQ)
GCK65_12605	COG2766	serine protein kinase
GCK65_12615	COG2719	SpoVR family
GCK65_12620	COG2186	Transcriptional regulator
GCK65_12625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCK65_12630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GCK65_12635	COG0586	Pfam SNARE associated Golgi protein
GCK65_12645	COG0556	nucleotide-excision repair
GCK65_12660	COG0569	domain protein
GCK65_12660	COG2985	domain, Protein
GCK65_12665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCK65_12685	COG4565	transcriptional regulatory protein
GCK65_12690	COG3290	protein histidine kinase activity
GCK65_12695	COG1846	Transcriptional regulator
GCK65_12695	COG1940	carbohydrate kinase activity
GCK65_12700	COG0840	transmembrane signaling receptor activity
GCK65_12705	COG3012	SEC-C Motif Domain Protein
GCK65_12710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GCK65_12715	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GCK65_12720	COG0247	lactate metabolic process
GCK65_12730	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GCK65_12735	COG0437	4 iron, 4 sulfur cluster binding
GCK65_12740	COG3301	Polysulphide reductase, NrfD
GCK65_12745	COG1138	Cytochrome C-type biogenesis protein
GCK65_12750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCK65_12755	COG3088	subunit of a heme lyase
GCK65_12755	COG4235	cytochrome complex assembly
GCK65_12760	COG1051	belongs to the nudix hydrolase family
GCK65_12770	COG3033	Beta-eliminating lyase
GCK65_12780	COG3046	protein related to deoxyribodipyrimidine photolyase
GCK65_12785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCK65_12830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GCK65_12845	COG4774	siderophore transport
GCK65_12860	COG0583	DNA-binding transcription factor activity
GCK65_12865	COG2910	NAD(P)H-binding
GCK65_12875	COG0626	cystathionine gamma-synthase activity
GCK65_12880	COG0612	Peptidase, M16
GCK65_12885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCK65_12895	COG1944	ATP diphosphatase activity
GCK65_12900	COG2116	formate transmembrane transporter activity
GCK65_12905	COG1882	Formate acetyltransferase
GCK65_12910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCK65_12915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GCK65_12920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GCK65_12930	COG1840	ABC-type Fe3 transport system, periplasmic component
GCK65_12935	COG3842	ATPase activity
GCK65_12945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCK65_12950	COG2983	Belongs to the UPF0260 family
GCK65_12960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCK65_12965	COG0045	succinate-CoA ligase (ADP-forming) activity
GCK65_12970	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCK65_12975	COG0567	Dehydrogenase, E1 component
GCK65_12985	COG1053	succinate dehydrogenase
GCK65_12990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GCK65_13015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCK65_13020	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GCK65_13020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCK65_13030	COG3069	C4-dicarboxylate transmembrane transporter activity
GCK65_13045	COG1451	nucleotide metabolic process
GCK65_13060	COG0254	rRNA binding
GCK65_13065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCK65_13075	COG0583	DNA-binding transcription factor activity
GCK65_13085	COG1172	Belongs to the binding-protein-dependent transport system permease family
GCK65_13095	COG1879	ABC-type sugar transport system periplasmic component
GCK65_13100	COG1069	ribulokinase activity
GCK65_13110	COG2160	L-arabinose isomerase activity
GCK65_13115	COG2925	Exonuclease
GCK65_13125	COG3345	alpha-galactosidase
GCK65_13130	COG1380	Effector of murein hydrolase LrgA
GCK65_13135	COG1346	cytolysis
GCK65_13140	COG0295	cytidine deaminase activity
GCK65_13145	COG1022	Amp-dependent synthetase and ligase
GCK65_13160	COG0861	Integral membrane protein TerC family
GCK65_13165	COG2885	chlorophyll binding
GCK65_13170	COG2199	diguanylate cyclase activity
GCK65_13190	COG2154	pterin-4-alpha-carbinolamine dehydratase
GCK65_13200	COG3768	UPF0283 membrane protein
GCK65_13205	COG3106	COG3106 Predicted ATPase
GCK65_13220	COG1842	Phage shock protein A
GCK65_13225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GCK65_13235	COG4168	peptide transport system, permease
GCK65_13240	COG4171	peptide transport system, permease
GCK65_13250	COG4172	Belongs to the ABC transporter superfamily
GCK65_13260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GCK65_13265	COG1286	toxin biosynthetic process
GCK65_13270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GCK65_13275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GCK65_13280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GCK65_13285	COG0531	amino acid
GCK65_13285	COG1674	ftsk spoiiie
GCK65_13295	COG0686	Belongs to the AlaDH PNT family
GCK65_13300	COG0492	ferredoxin-NADP+ reductase activity
GCK65_13305	COG3706	GGDEF domain
GCK65_13310	COG3134	Outer membrane lipoprotein
GCK65_13315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GCK65_13320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GCK65_13325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GCK65_13330	COG0542	response to heat
GCK65_13335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GCK65_13340	COG1278	Cold shock
GCK65_13345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GCK65_13405	COG3829	transcription factor binding
GCK65_13480	COG3501	Rhs element vgr protein
GCK65_13505	COG1435	thymidine kinase activity
GCK65_13510	COG1757	Na H antiporter
GCK65_13515	COG2916	Histone family protein nucleoid-structuring protein H-NS
GCK65_13520	COG2096	Adenosyltransferase
GCK65_13525	COG3530	Putative quorum-sensing-regulated virulence factor
GCK65_13530	COG0602	queuosine metabolic process
GCK65_13535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCK65_13555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GCK65_13565	COG0776	regulation of translation
GCK65_13570	COG0539	negative regulation of cytoplasmic translation
GCK65_13575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GCK65_13580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GCK65_13610	COG0778	Nitroreductase
GCK65_13615	COG3300	MHYT domain
GCK65_13615	COG5001	Diguanylate cyclase
GCK65_13625	COG0583	DNA-binding transcription factor activity
GCK65_13630	COG3437	response regulator, receiver
GCK65_13655	COG4989	oxidoreductase activity
GCK65_13660	COG0724	RNA recognition motif
GCK65_13680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GCK65_13695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCK65_13700	COG1360	Flagellar Motor Protein
GCK65_13705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_13710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_13715	COG0649	NAD binding
GCK65_13715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_13730	COG1034	ATP synthesis coupled electron transport
GCK65_13735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCK65_13740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_13745	COG0839	Belongs to the complex I subunit 6 family
GCK65_13750	COG0713	ATP synthesis coupled electron transport
GCK65_13760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCK65_13765	COG1007	ATP synthesis coupled electron transport
GCK65_13780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCK65_13780	COG2199	diguanylate cyclase activity
GCK65_13785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GCK65_13785	COG0047	phosphoribosylformylglycinamidine synthase activity
GCK65_13790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCK65_13800	COG1645	bacterial-type flagellum-dependent swarming motility
GCK65_13805	COG1160	GTP binding
GCK65_13810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCK65_13815	COG2976	Protein conserved in bacteria
GCK65_13820	COG0124	histidyl-tRNA synthetase
GCK65_13825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GCK65_13840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GCK65_13845	COG0105	UTP biosynthetic process
GCK65_13850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCK65_13860	COG0633	Ferredoxin
GCK65_13865	COG0443	Heat shock 70 kDa protein
GCK65_13870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCK65_13880	COG0822	iron-sulfur transferase activity
GCK65_13885	COG1104	cysteine desulfurase activity
GCK65_13905	COG3154	lipid carrier protein
GCK65_13910	COG0826	peptidase U32
GCK65_13915	COG0826	peptidase U32
GCK65_13930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCK65_13935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCK65_13940	COG1862	Preprotein translocase
GCK65_13945	COG0343	queuine tRNA-ribosyltransferase activity
GCK65_13950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GCK65_13955	COG0517	IMP dehydrogenase activity
GCK65_13965	COG3634	alkyl hydroperoxide reductase activity
GCK65_13985	COG1393	Belongs to the ArsC family
GCK65_13990	COG0798	PFAM Bile acid sodium symporter
GCK65_13995	COG0640	Transcriptional regulator
GCK65_14000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCK65_14000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCK65_14005	COG0509	glycine decarboxylation via glycine cleavage system
GCK65_14010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCK65_14015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCK65_14020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCK65_14040	COG2814	Major facilitator Superfamily
GCK65_14045	COG0625	glutathione transferase activity
GCK65_14055	COG0483	inositol monophosphate 1-phosphatase activity
GCK65_14075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCK65_14120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GCK65_14140	COG0301	tRNA thio-modification
GCK65_14140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCK65_14150	COG4953	penicillin-binding protein 1C
GCK65_14155	COG2373	Large extracellular alpha-helical protein
GCK65_14160	COG0628	permease
GCK65_14165	COG1538	Outer membrane efflux protein
GCK65_14185	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCK65_14195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCK65_14230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCK65_14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_14280	COG2431	L-lysine efflux transmembrane transporter activity
GCK65_14290	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GCK65_14305	COG1393	Belongs to the ArsC family
GCK65_14315	COG4783	chaperone-mediated protein folding
GCK65_14320	COG0425	Belongs to the sulfur carrier protein TusA family
GCK65_14345	COG3842	ATPase activity
GCK65_14350	COG3833	ABC-type maltose transport systems, permease component
GCK65_14355	COG1175	transmembrane transport
GCK65_14365	COG3081	Nucleoid-associated protein
GCK65_14370	COG3082	Protein of unknown function (DUF1414)
GCK65_14375	COG3083	sulfuric ester hydrolase activity
GCK65_14385	COG4771	TonB-dependent receptor
GCK65_14390	COG1770	oligopeptidase
GCK65_14410	COG4574	serine-type endopeptidase inhibitor activity
GCK65_14415	COG3085	chromosome segregation
GCK65_14420	COG0583	DNA-binding transcription factor activity
GCK65_14425	COG0287	Prephenate dehydrogenase
GCK65_14425	COG1605	Chorismate mutase
GCK65_14430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCK65_14435	COG0584	glycerophosphoryl diester phosphodiesterase
GCK65_14445	COG1349	DNA-binding transcription factor activity
GCK65_14450	COG2271	Major facilitator Superfamily
GCK65_14455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GCK65_14460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GCK65_14465	COG0583	DNA-binding transcription factor activity
GCK65_14485	COG0656	L-ascorbic acid biosynthetic process
GCK65_14490	COG2814	Major facilitator Superfamily
GCK65_14505	COG3220	belongs to the UPF0276 family
GCK65_14525	COG1294	oxidase, subunit
GCK65_14535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GCK65_14545	COG2979	Protein of unknown function (DUF533)
GCK65_14570	COG2271	Major facilitator Superfamily
GCK65_14575	COG0583	DNA-binding transcription factor activity
GCK65_14585	COG2807	transmembrane transport
GCK65_14590	COG1187	pseudouridine synthase activity
GCK65_14610	COG0346	lactoylglutathione lyase activity
GCK65_14630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCK65_14635	COG0270	DNA (cytosine-5-)-methyltransferase activity
GCK65_14650	COG2964	Protein conserved in bacteria
GCK65_14655	COG3681	Belongs to the UPF0597 family
GCK65_14665	COG0814	amino acid
GCK65_14685	COG1166	arginine decarboxylase activity
GCK65_14705	COG2195	Cleaves the N-terminal amino acid of tripeptides
GCK65_14735	COG0583	DNA-binding transcription factor activity
GCK65_14745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GCK65_14755	COG0840	transmembrane signaling receptor activity
GCK65_14760	COG0302	gtp cyclohydrolase
GCK65_14770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCK65_14775	COG2267	carboxylic ester hydrolase activity
GCK65_14780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GCK65_14795	COG0314	molybdopterin synthase activity
GCK65_14800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GCK65_14805	COG0315	cyclic pyranopterin monophosphate synthase activity
GCK65_14810	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCK65_14815	COG3005	denitrification pathway
GCK65_14825	COG0348	domain, Protein
GCK65_14830	COG0437	4 iron, 4 sulfur cluster binding
GCK65_14835	COG0243	molybdopterin cofactor binding
GCK65_14845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_14845	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_14850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GCK65_14855	COG3850	Histidine kinase
GCK65_14860	COG2197	response regulator
GCK65_14890	COG0121	glutamine amidotransferase
GCK65_14895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCK65_14900	COG1960	acyl-CoA dehydrogenase activity
GCK65_14905	COG0784	Response regulator, receiver
GCK65_14905	COG3437	response regulator, receiver
GCK65_14920	COG0328	RNA-DNA hybrid ribonuclease activity
GCK65_14925	COG2226	methyltransferase
GCK65_14930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCK65_14935	COG0741	lytic transglycosylase activity
GCK65_14935	COG1388	LysM domain
GCK65_14940	COG3021	interspecies interaction between organisms
GCK65_14950	COG1607	acyl-coa hydrolase
GCK65_14965	COG0741	lytic transglycosylase activity
GCK65_14975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GCK65_14995	COG2911	Protein conserved in bacteria
GCK65_15000	COG0729	surface antigen
GCK65_15010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCK65_15020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCK65_15030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCK65_15040	COG4134	Bacterial extracellular solute-binding protein
GCK65_15050	COG4136	ATPase activity
GCK65_15055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCK65_15060	COG2951	lytic endotransglycosylase activity
GCK65_15065	COG1846	Transcriptional regulator
GCK65_15075	COG0033	Phosphoglucomutase
GCK65_15080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GCK65_15085	COG0596	Alpha beta hydrolase
GCK65_15100	COG0716	FMN binding
GCK65_15110	COG0735	belongs to the Fur family
GCK65_15115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCK65_15125	COG1263	PTS System
GCK65_15125	COG2190	(PTS) system
GCK65_15125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_15130	COG0363	glucosamine-6-phosphate deaminase activity
GCK65_15135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GCK65_15140	COG1940	carbohydrate kinase activity
GCK65_15140	COG1846	Transcriptional regulator
GCK65_15145	COG2194	sulfuric ester hydrolase activity
GCK65_15150	COG0217	transcriptional regulatory protein
GCK65_15155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GCK65_15165	COG1801	Protein of unknown function DUF72
GCK65_15170	COG4106	trans-aconitate 2-methyltransferase activity
GCK65_15175	COG0500	methyltransferase
GCK65_15195	COG0450	alkyl hydroperoxide reductase
GCK65_15200	COG0583	DNA-binding transcription factor activity
GCK65_15210	COG0791	NLP P60 protein
GCK65_15225	COG1309	transcriptional regulator
GCK65_15265	COG0534	Mate efflux family protein
GCK65_15285	COG2366	antibiotic biosynthetic process
GCK65_15290	COG0674	pyruvate-flavodoxin oxidoreductase activity
GCK65_15290	COG1013	pyruvate-flavodoxin oxidoreductase activity
GCK65_15290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GCK65_15290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCK65_15300	COG3217	Mosc domain protein beta barrel domain protein
GCK65_15300	COG3217	Mosc domain protein beta barrel domain protein
GCK65_15300	COG0633	Ferredoxin
GCK65_15300	COG0633	Ferredoxin
GCK65_15310	COG0501	Belongs to the peptidase M48B family
GCK65_15315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GCK65_15320	COG2226	methyltransferase
GCK65_15320	COG1073	alpha beta
GCK65_15325	COG0156	8-amino-7-oxononanoate synthase activity
GCK65_15330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GCK65_15350	COG0017	Asparaginyl-tRNA synthetase
GCK65_15355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GCK65_15365	COG1473	amidohydrolase
GCK65_15370	COG3069	C4-dicarboxylate transmembrane transporter activity
GCK65_15380	COG0583	DNA-binding transcription factor activity
GCK65_15385	COG1393	Belongs to the ArsC family
GCK65_15390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCK65_15395	COG1876	peptidase activity
GCK65_15405	COG3263	regulation of cellular component size
GCK65_15415	COG3263	regulation of cellular component size
GCK65_15425	COG1280	lysine exporter protein (LysE YggA)
GCK65_15455	COG0564	pseudouridine synthase activity
GCK65_15465	COG1454	alcohol dehydrogenase
GCK65_15470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCK65_15475	COG0702	epimerase
GCK65_15480	COG2914	Belongs to the UPF0125 (RnfH) family
GCK65_15485	COG2867	negative regulation of translational initiation
GCK65_15490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GCK65_15505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GCK65_15510	COG0583	DNA-binding transcription factor activity
GCK65_15515	COG2610	gluconate transmembrane transporter activity
GCK65_15520	COG3048	D-serine ammonia-lyase activity
GCK65_15530	COG0538	isocitrate dehydrogenase activity
GCK65_15535	COG2207	Transcriptional regulator
GCK65_15555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_15565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GCK65_15570	COG1263	PTS System
GCK65_15570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_15575	COG1609	Transcriptional regulator
GCK65_15585	COG0789	Transcriptional regulator
GCK65_15600	COG0456	acetyltransferase
GCK65_15610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_15610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_15610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_15620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCK65_15630	COG1187	pseudouridine synthase activity
GCK65_15640	COG0482	sulfurtransferase activity
GCK65_15645	COG2915	High frequency lysogenization protein hflD homolog
GCK65_15650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GCK65_15655	COG2850	peptidyl-arginine hydroxylation
GCK65_15660	COG3153	acetyltransferase
GCK65_15670	COG0625	glutathione transferase activity
GCK65_15675	COG0259	pyridoxamine-phosphate oxidase activity
GCK65_15690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCK65_15690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCK65_15695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCK65_15710	COG3088	subunit of a heme lyase
GCK65_15710	COG4235	cytochrome complex assembly
GCK65_15715	COG3088	subunit of a heme lyase
GCK65_15715	COG4235	cytochrome complex assembly
GCK65_15720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCK65_15725	COG1138	Cytochrome C-type biogenesis protein
GCK65_15730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GCK65_15735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCK65_15740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCK65_15745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCK65_15760	COG0835	chemotaxis
GCK65_15770	COG1192	Involved in chromosome partitioning
GCK65_15775	COG1360	Flagellar Motor Protein
GCK65_15780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCK65_15785	COG2201	protein-glutamate methylesterase activity
GCK65_15790	COG0643	Histidine kinase
GCK65_15790	COG0784	Response regulator, receiver
GCK65_15790	COG2198	Histidine kinase
GCK65_15795	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GCK65_15820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCK65_15830	COG1684	flagellar biosynthetic protein fliR
GCK65_15885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GCK65_15895	COG1677	Flagellar hook-basal body complex protein FliE
GCK65_15910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCK65_15915	COG3064	Membrane
GCK65_15915	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GCK65_15915	COG1073	alpha beta
GCK65_15920	COG2994	toxin metabolic process
GCK65_15930	COG2274	protein secretion by the type I secretion system
GCK65_15940	COG2274	protein secretion by the type I secretion system
GCK65_15960	COG1737	Transcriptional regulator
GCK65_15965	COG0469	pyruvate kinase activity
GCK65_15975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCK65_15980	COG1960	acyl-CoA dehydrogenase activity
GCK65_15990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GCK65_16000	COG0243	molybdopterin cofactor binding
GCK65_16005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCK65_16010	COG0583	DNA-binding transcription factor activity
GCK65_16045	COG1454	alcohol dehydrogenase
GCK65_16045	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_16055	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_16055	COG1454	alcohol dehydrogenase
GCK65_16060	COG1882	Formate acetyltransferase
GCK65_16065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCK65_16075	COG4869	propanediol catabolic process
GCK65_16105	COG1388	LysM domain
GCK65_16105	COG1376	ErfK ybiS ycfS ynhG family protein
GCK65_16120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GCK65_16125	COG0791	NLP P60 protein
GCK65_16130	COG2091	lysine biosynthetic process via aminoadipic acid
GCK65_16135	COG3118	belongs to the thioredoxin family
GCK65_16145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GCK65_16150	COG0788	formyltetrahydrofolate deformylase activity
GCK65_16160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCK65_16180	COG0366	Alpha amylase catalytic
GCK65_16185	COG1196	nuclear chromosome segregation
GCK65_16185	COG0739	heme binding
GCK65_16185	COG0741	lytic transglycosylase activity
GCK65_16190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GCK65_16195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GCK65_16205	COG0673	inositol 2-dehydrogenase activity
GCK65_16240	COG1032	radical SAM domain protein
GCK65_16250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCK65_16255	COG1566	PFAM secretion protein HlyD family protein
GCK65_16260	COG2199	diguanylate cyclase activity
GCK65_16260	COG2203	Gaf domain
GCK65_16265	COG1752	Esterase of the alpha-beta hydrolase superfamily
GCK65_16270	COG0733	neurotransmitter:sodium symporter activity
GCK65_16300	COG0281	malic enzyme
GCK65_16310	COG0534	Mate efflux family protein
GCK65_16325	COG2233	PERMEase
GCK65_16330	COG0095	Lipoate-protein ligase
GCK65_16335	COG1115	amino acid carrier protein
GCK65_16340	COG0019	diaminopimelate decarboxylase activity
GCK65_16350	COG0678	peroxiredoxin activity
GCK65_16360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GCK65_16380	COG1131	(ABC) transporter
GCK65_16385	COG0545	Peptidyl-prolyl cis-trans isomerase
GCK65_16390	COG3142	Participates in the control of copper homeostasis
GCK65_16415	COG5002	protein histidine kinase activity
GCK65_16420	COG0745	RESPONSE REGULATOR receiver
GCK65_16425	COG0346	lactoylglutathione lyase activity
GCK65_16430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GCK65_16435	COG1960	acyl-CoA dehydrogenase activity
GCK65_16440	COG3284	Transcriptional regulator
GCK65_16455	COG0697	spore germination
GCK65_16460	COG4565	transcriptional regulatory protein
GCK65_16465	COG3290	protein histidine kinase activity
GCK65_16485	COG1846	Transcriptional regulator
GCK65_16490	COG1566	PFAM secretion protein HlyD family protein
GCK65_16520	COG0602	queuosine metabolic process
GCK65_16525	COG1328	CTP reductase activity
GCK65_16535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCK65_16540	COG3115	cell septum assembly
GCK65_16545	COG1196	nuclear chromosome segregation
GCK65_16555	COG2860	membrane
GCK65_16565	COG3108	Peptidase M15
GCK65_16570	COG2989	Protein conserved in bacteria
GCK65_16585	COG0463	Glycosyl transferase, family 2
GCK65_16600	COG0366	Alpha amylase catalytic
GCK65_16635	COG3706	GGDEF domain
GCK65_16645	COG3590	peptidase
GCK65_16655	COG0488	(ABC) transporter
GCK65_16665	COG0531	amino acid
GCK65_16680	COG0814	amino acid
GCK65_16695	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GCK65_16700	COG1982	Orn Lys Arg decarboxylase major
GCK65_16705	COG0531	amino acid
GCK65_16710	COG3710	Transcriptional regulator
GCK65_16715	COG0825	malonyl-CoA metabolic process
GCK65_16725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GCK65_16730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCK65_16735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCK65_16740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCK65_16745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCK65_16760	COG0750	zinc metalloprotease
GCK65_16765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GCK65_16770	COG0575	Belongs to the CDS family
GCK65_16775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GCK65_16780	COG0233	cytoplasmic translational termination
GCK65_16785	COG0528	UMP kinase activity
GCK65_16790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GCK65_16795	COG0052	Belongs to the universal ribosomal protein uS2 family
GCK65_16800	COG0024	Methionine aminopeptidase
GCK65_16805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GCK65_16810	COG2171	N-acyltransferase activity
GCK65_16820	COG1263	PTS System
GCK65_16820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_16830	COG4580	involved in the transport of maltose and maltodextrins
GCK65_16840	COG0564	pseudouridine synthase activity
GCK65_16845	COG3098	single-species biofilm formation
GCK65_16870	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GCK65_16880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCK65_16880	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCK65_16895	COG1611	Belongs to the LOG family
GCK65_16900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCK65_16905	COG0473	3-isopropylmalate dehydrogenase activity
GCK65_16915	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GCK65_16920	COG2363	Small membrane protein
GCK65_16930	COG0583	DNA-binding transcription factor activity
GCK65_16935	COG0840	transmembrane signaling receptor activity
GCK65_16940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GCK65_16955	COG1477	protein flavinylation
GCK65_16960	COG2871	sodium ion transport
GCK65_16965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCK65_16970	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCK65_16975	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCK65_16980	COG1805	sodium ion transport
GCK65_16985	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCK65_16990	COG0271	Belongs to the BolA IbaG family
GCK65_16995	COG2813	Specifically methylates the guanine in position
GCK65_17005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCK65_17015	COG2211	Major facilitator Superfamily
GCK65_17020	COG3248	Nucleoside-binding outer membrane protein
GCK65_17025	COG1666	GTP binding
GCK65_17030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GCK65_17035	COG0693	protein deglycase activity
GCK65_17090	COG2771	luxR family
GCK65_17105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCK65_17105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCK65_17110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCK65_17120	COG1151	hydroxylamine reductase activity
GCK65_17125	COG0783	Belongs to the Dps family
GCK65_17150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCK65_17165	COG4221	oxidoreductase activity
GCK65_17175	COG0415	Belongs to the DNA photolyase family
GCK65_17180	COG0789	Transcriptional regulator
GCK65_17185	COG3272	Protein of unknown function (DUF1722)
GCK65_17215	COG0077	Prephenate dehydratase
GCK65_17215	COG1605	Chorismate mutase
GCK65_17250	COG2133	pyrroloquinoline quinone binding
GCK65_17255	COG1349	DNA-binding transcription factor activity
GCK65_17260	COG2084	Dehydrogenase
GCK65_17270	COG0235	Class ii aldolase
GCK65_17275	COG3622	Belongs to the hyi family
GCK65_17280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCK65_17285	COG2610	gluconate transmembrane transporter activity
GCK65_17295	COG0840	transmembrane signaling receptor activity
GCK65_17305	COG0300	oxidoreductase activity
GCK65_17330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GCK65_17355	COG0826	peptidase U32
GCK65_17360	COG1280	lysine exporter protein (LysE YggA)
GCK65_17370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GCK65_17375	COG0840	transmembrane signaling receptor activity
GCK65_17390	COG2198	Histidine kinase
GCK65_17390	COG0643	Histidine kinase
GCK65_17400	COG0835	chemotaxis
GCK65_17405	COG0840	transmembrane signaling receptor activity
GCK65_17415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GCK65_17420	COG2201	protein-glutamate methylesterase activity
GCK65_17425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GCK65_17455	COG2197	response regulator
GCK65_17465	COG3188	usher protein
GCK65_17480	COG2199	diguanylate cyclase activity
GCK65_17480	COG2200	EAL domain
GCK65_17480	COG2203	Gaf domain
GCK65_17485	COG0826	peptidase U32
GCK65_17490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCK65_17495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCK65_17500	COG0305	Participates in initiation and elongation during chromosome replication
GCK65_17515	COG2200	EAL domain
GCK65_17520	COG0737	Belongs to the 5'-nucleotidase family
GCK65_17540	COG2204	response regulator
GCK65_17545	COG0545	Peptidyl-prolyl cis-trans isomerase
GCK65_17560	COG1047	Peptidyl-prolyl cis-trans
GCK65_17565	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GCK65_17575	COG0784	Response regulator, receiver
GCK65_17575	COG0835	chemotaxis
GCK65_17580	COG0429	hydrolase of the alpha beta-hydrolase fold
GCK65_17585	COG5001	Diguanylate cyclase
GCK65_17585	COG4251	negative regulation of phosphorylation
GCK65_17585	COG3706	GGDEF domain
GCK65_17585	COG2203	Gaf domain
GCK65_17590	COG3089	Belongs to the UPF0270 family
GCK65_17600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GCK65_17605	COG0463	Glycosyl transferase, family 2
GCK65_17610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCK65_17610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCK65_17615	COG0726	polysaccharide deacetylase
GCK65_17620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GCK65_17625	COG2076	Multidrug Resistance protein
GCK65_17630	COG2076	Multidrug Resistance protein
GCK65_17635	COG3954	Phosphoribulokinase
GCK65_17650	COG1765	OsmC-like protein
GCK65_17660	COG2226	methyltransferase
GCK65_17665	COG3397	chitin binding
GCK65_17680	COG2202	Pas domain
GCK65_17680	COG2205	protein histidine kinase activity
GCK65_17690	COG3655	Transcriptional regulator
GCK65_17695	COG2814	Major facilitator Superfamily
GCK65_17705	COG4771	TonB-dependent receptor
GCK65_17725	COG0748	coenzyme F420 binding
GCK65_17730	COG3721	Heme iron utilization protein
GCK65_17740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCK65_17765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GCK65_17770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCK65_17775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GCK65_17795	COG0741	lytic transglycosylase activity
GCK65_17800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCK65_17815	COG0488	(ABC) transporter
GCK65_17825	COG2252	PERMEase
GCK65_17830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCK65_17835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GCK65_17840	COG3178	'Phosphotransferase
GCK65_17845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GCK65_17855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GCK65_17860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCK65_17865	COG2967	ApaG domain
GCK65_17870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCK65_17880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCK65_17885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCK65_17900	COG0318	PFAM AMP-dependent synthetase and ligase
GCK65_17905	COG3314	Sporulation integral membrane protein YlbJ
GCK65_17910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCK65_17915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GCK65_17920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GCK65_17925	COG0142	geranyltranstransferase activity
GCK65_17930	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GCK65_17935	COG0330	HflC and HflK could
GCK65_17940	COG0330	HflC and HflK could
GCK65_17945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GCK65_17950	COG1923	regulation of RNA biosynthetic process
GCK65_17955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GCK65_17960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCK65_17970	COG0802	atpase or kinase
GCK65_17975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GCK65_17975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GCK65_17980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GCK65_18000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GCK65_18005	COG2011	ABC-type metal ion transport system permease component
GCK65_18010	COG1464	Belongs to the NlpA lipoprotein family
GCK65_18025	COG0840	transmembrane signaling receptor activity
GCK65_18050	COG5002	protein histidine kinase activity
GCK65_18050	COG0784	Response regulator, receiver
GCK65_18050	COG2198	Histidine kinase
GCK65_18070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GCK65_18085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GCK65_18090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GCK65_18100	COG2716	regulation of RNA biosynthetic process
GCK65_18105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCK65_18110	COG3013	Belongs to the UPF0304 family
GCK65_18120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCK65_18125	COG0857	belongs to the CobB CobQ family
GCK65_18125	COG0280	phosphate acetyltransferase
GCK65_18140	COG0028	Belongs to the TPP enzyme family
GCK65_18150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCK65_18155	COG0671	phosphoesterase, PA-phosphatase related
GCK65_18165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCK65_18170	COG0473	3-isopropylmalate dehydrogenase activity
GCK65_18175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCK65_18180	COG0066	3-isopropylmalate dehydratase activity
GCK65_18200	COG1178	ABC-type Fe3 transport system permease component
GCK65_18205	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GCK65_18210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GCK65_18220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCK65_18250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCK65_18255	COG0564	pseudouridine synthase activity
GCK65_18265	COG3300	MHYT domain
GCK65_18265	COG5001	Diguanylate cyclase
GCK65_18275	COG0459	protein refolding
GCK65_18280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GCK65_18285	COG0534	Mate efflux family protein
GCK65_18290	COG3030	protein affecting phage T7 exclusion by the F plasmid
GCK65_18295	COG1027	Aspartate ammonia-lyase
GCK65_18300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GCK65_18310	COG0477	Major facilitator Superfamily
GCK65_18325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCK65_18330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCK65_18340	COG0673	inositol 2-dehydrogenase activity
GCK65_18350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GCK65_18355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCK65_18360	COG3036	rescue of stalled ribosome
GCK65_18365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GCK65_18375	COG0138	bifunctional purine biosynthesis protein purh
GCK65_18380	COG0151	Belongs to the GarS family
GCK65_18405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCK65_18410	COG0358	DNA primase activity
GCK65_18415	COG1610	YqeY-like protein
GCK65_18420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GCK65_18425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GCK65_18440	COG1238	metal cluster binding
GCK65_18445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GCK65_18450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GCK65_18455	COG0585	pseudouridine synthase activity
GCK65_18465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GCK65_18470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GCK65_18475	COG0148	phosphopyruvate hydratase activity
GCK65_18480	COG0504	CTP synthase activity
GCK65_18485	COG3956	TIGRFAM MazG family protein
GCK65_18490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCK65_18495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCK65_18505	COG4807	Protein conserved in bacteria
GCK65_18510	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCK65_18515	COG1349	DNA-binding transcription factor activity
GCK65_18525	COG2222	sugar isomerase
GCK65_18530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_18540	COG3716	PTS system mannose fructose sorbose family IID component
GCK65_18545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_18550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GCK65_18565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GCK65_18570	COG1381	Involved in DNA repair and RecF pathway recombination
GCK65_18580	COG0571	ribonuclease III activity
GCK65_18585	COG0681	Belongs to the peptidase S26 family
GCK65_18590	COG0481	GTPase activity
GCK65_18605	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GCK65_18610	COG1595	DNA-templated transcription, initiation
GCK65_18615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GCK65_18625	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GCK65_18665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCK65_18675	COG0126	phosphoglycerate kinase activity
GCK65_18680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCK65_18685	COG1940	carbohydrate kinase activity
GCK65_18690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GCK65_18705	COG4991	sh3 domain protein
GCK65_18710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCK65_18725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GCK65_18730	COG1028	Short-chain dehydrogenase reductase Sdr
GCK65_18740	COG2982	Protein involved in outer membrane biogenesis
GCK65_18750	COG1505	serine-type exopeptidase activity
GCK65_18755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GCK65_18760	COG0765	amino acid transport
GCK65_18765	COG0765	amino acid transport
GCK65_18770	COG1126	abc transporter atp-binding protein
GCK65_18775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_18780	COG1136	(ABC) transporter
GCK65_18780	COG0577	efflux transmembrane transporter activity
GCK65_18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCK65_18790	COG0745	RESPONSE REGULATOR receiver
GCK65_18795	COG2205	protein histidine kinase activity
GCK65_18800	COG2816	NAD+ diphosphatase activity
GCK65_18835	COG2070	2-Nitropropane dioxygenase
GCK65_18860	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GCK65_18880	COG0513	Belongs to the DEAD box helicase family
GCK65_18895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GCK65_18900	COG0154	amidase activity
GCK65_18905	COG2957	Belongs to the agmatine deiminase family
GCK65_18915	COG2852	Protein conserved in bacteria
GCK65_18925	COG1902	pentaerythritol trinitrate reductase activity
GCK65_18965	COG3300	MHYT domain
GCK65_18965	COG5001	Diguanylate cyclase
GCK65_18975	COG0714	Associated with various cellular activities
GCK65_18985	COG0456	acetyltransferase
GCK65_18995	COG1022	Amp-dependent synthetase and ligase
GCK65_19000	COG2918	glutathione biosynthetic process
GCK65_19005	COG0612	Peptidase, M16
GCK65_19010	COG1238	metal cluster binding
GCK65_19035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCK65_19040	COG0359	binds to the 23S rRNA
GCK65_19045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GCK65_19050	COG0360	Binds together with S18 to 16S ribosomal RNA
GCK65_19055	COG1914	H( )-stimulated, divalent metal cation uptake system
GCK65_19075	COG2153	protein acetylation
GCK65_19085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCK65_19090	COG0557	exoribonuclease II activity
GCK65_19095	COG3706	GGDEF domain
GCK65_19100	COG1854	S-ribosylhomocysteine lyase activity
GCK65_19115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GCK65_19115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCK65_19175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GCK65_19180	COG1047	Peptidyl-prolyl cis-trans
GCK65_19185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GCK65_19190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GCK65_19195	COG0196	riboflavin kinase activity
GCK65_19200	COG0728	peptidoglycan biosynthetic process
GCK65_19205	COG0268	Binds directly to 16S ribosomal RNA
GCK65_19210	COG0640	Transcriptional regulator
GCK65_19215	COG0583	DNA-binding transcription factor activity
GCK65_19225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCK65_19230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GCK65_19235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GCK65_19245	COG1051	belongs to the nudix hydrolase family
GCK65_19250	COG3066	DNA modification
GCK65_19260	COG0335	large ribosomal subunit rRNA binding
GCK65_19265	COG0336	Belongs to the RNA methyltransferase TrmD family
GCK65_19270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GCK65_19275	COG0228	four-way junction DNA binding
GCK65_19280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCK65_19285	COG4137	Cytochrome C assembly protein
GCK65_19290	COG4536	flavin adenine dinucleotide binding
GCK65_19300	COG1017	nitric oxide dioxygenase activity
GCK65_19300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCK65_19305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GCK65_19310	COG0039	L-malate dehydrogenase activity
GCK65_19315	COG4160	amino acid transport
GCK65_19320	COG4215	(ABC) transporter
GCK65_19325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCK65_19330	COG1126	abc transporter atp-binding protein
GCK65_19335	COG1438	arginine binding
GCK65_19340	COG2837	iron assimilation
GCK65_19345	COG3842	ATPase activity
GCK65_19355	COG1840	ABC-type Fe3 transport system, periplasmic component
GCK65_19360	COG0347	Belongs to the P(II) protein family
GCK65_19375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCK65_19380	COG0583	DNA-binding transcription factor activity
GCK65_19395	COG1929	Belongs to the glycerate kinase type-1 family
GCK65_19400	COG2610	gluconate transmembrane transporter activity
GCK65_19405	COG3835	regulator
GCK65_19410	COG3112	Uncharacterised protein family (UPF0231)
GCK65_19425	COG0840	transmembrane signaling receptor activity
GCK65_19445	COG0513	Belongs to the DEAD box helicase family
GCK65_19485	COG1448	Aminotransferase
GCK65_19500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCK65_19505	COG1328	CTP reductase activity
GCK65_19525	COG0793	Belongs to the peptidase S41A family
GCK65_19525	COG4946	Tricorn protease homolog
GCK65_19560	COG3397	chitin binding
GCK65_19565	COG0583	DNA-binding transcription factor activity
GCK65_19570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GCK65_19575	COG4208	sulfate ABC transporter
GCK65_19580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GCK65_19590	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GCK65_19595	COG3174	membrane
GCK65_19600	COG0110	maltose O-acetyltransferase activity
GCK65_19630	COG0165	Argininosuccinate lyase
GCK65_19635	COG0137	argininosuccinate synthase activity
GCK65_19645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCK65_19650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GCK65_19660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GCK65_19665	COG0527	aspartate kinase activity
GCK65_19665	COG0460	homoserine dehydrogenase
GCK65_19670	COG0626	cystathionine gamma-synthase activity
GCK65_19680	COG3708	Transcriptional regulator
GCK65_19680	COG2207	Transcriptional regulator
GCK65_19685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCK65_19690	COG0814	amino acid
GCK65_19695	COG1218	3'(2'),5'-bisphosphate nucleotidase
GCK65_19700	COG0494	nUDIX hydrolase
GCK65_19705	COG1011	Hydrolase
GCK65_19710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GCK65_19725	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GCK65_19735	COG3156	type II secretion system protein K
GCK65_19745	COG4795	General secretion pathway protein
GCK65_19750	COG2165	general secretion pathway protein
GCK65_19765	COG2165	general secretion pathway protein
GCK65_19770	COG1459	type II secretion system
GCK65_19775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCK65_19785	COG3031	protein transport across the cell outer membrane
GCK65_19795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GCK65_19800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GCK65_19820	COG0456	acetyltransferase
GCK65_19825	COG3133	Outer membrane lipoprotein
GCK65_19840	COG2771	luxR family
GCK65_19845	COG3916	Acyl-homoserine-lactone synthase
GCK65_19855	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GCK65_19860	COG1309	transcriptional regulator
GCK65_19870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCK65_19870	COG2213	PTS system mannitol-specific
GCK65_19875	COG0246	Mannitol dehydrogenase
GCK65_19880	COG3722	fumarate hydratase activity
GCK65_19885	COG3263	regulation of cellular component size
GCK65_19910	COG1671	Belongs to the UPF0178 family
GCK65_19925	COG1988	membrane-bound metal-dependent
GCK65_19930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCK65_19935	COG0513	Belongs to the DEAD box helicase family
GCK65_19965	COG1575	Belongs to the MenA family. Type 1 subfamily
GCK65_19970	COG1169	isochorismate synthase
GCK65_19975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GCK65_19980	COG0596	Alpha beta hydrolase
GCK65_19985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GCK65_19990	COG1441	menaquinone biosynthetic process
GCK65_19995	COG0318	PFAM AMP-dependent synthetase and ligase
GCK65_20010	COG3539	Fimbrial protein
GCK65_20015	COG3121	Chaperone
GCK65_20020	COG3188	usher protein
GCK65_20030	COG3539	Fimbrial protein
GCK65_20040	COG3291	Pkd domain containing protein
GCK65_20045	COG2949	membrane
GCK65_20050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GCK65_20065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GCK65_20070	COG5380	lipid catabolic process
GCK65_20095	COG2873	o-acetylhomoserine
GCK65_20105	COG1979	alcohol dehydrogenase
GCK65_20125	COG4221	oxidoreductase activity
GCK65_20145	COG1285	pathogenesis
GCK65_20165	COG1368	sulfuric ester hydrolase activity
GCK65_20170	COG1522	sequence-specific DNA binding
GCK65_20180	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GCK65_20185	COG1418	mRNA catabolic process
GCK65_20190	COG1058	Belongs to the CinA family
GCK65_20190	COG1546	Belongs to the CinA family
GCK65_20200	COG0842	Transport permease protein
GCK65_20200	COG1129	ABC transporter
GCK65_20215	COG0561	phosphatase activity
GCK65_20220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GCK65_20240	COG1011	Hydrolase
GCK65_20255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GCK65_20260	COG0019	diaminopimelate decarboxylase activity
GCK65_20270	COG1965	Belongs to the frataxin family
GCK65_20275	COG0400	carboxylic ester hydrolase activity
GCK65_20280	COG3072	Adenylate cyclase
GCK65_20285	COG0181	hydroxymethylbilane synthase activity
GCK65_20295	COG2959	enzyme of heme biosynthesis
GCK65_20310	COG1494	fructose-1,6-bisphosphatase
GCK65_20350	COG1733	regulation of RNA biosynthetic process
GCK65_20370	COG3932	Exopolysaccharide synthesis, ExoD
GCK65_20375	COG0814	amino acid
GCK65_20380	COG3706	GGDEF domain
GCK65_20395	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
GCK65_20415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GCK65_20420	COG2022	thiamine diphosphate biosynthetic process
GCK65_20430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCK65_20435	COG0352	thiamine-phosphate diphosphorylase activity
GCK65_20440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GCK65_20460	COG0745	RESPONSE REGULATOR receiver
GCK65_20465	COG0642	Histidine kinase
GCK65_20475	COG0189	ligase activity
GCK65_20500	COG1639	'signal transduction protein
GCK65_20510	COG2321	neutral zinc metallopeptidase
GCK65_20515	COG3700	Belongs to the class B bacterial acid phosphatase family
GCK65_20535	COG1366	Belongs to the anti-sigma-factor antagonist family
GCK65_20540	COG2172	sigma factor antagonist activity
GCK65_20545	COG2205	protein histidine kinase activity
GCK65_20545	COG5002	protein histidine kinase activity
GCK65_20545	COG0784	Response regulator, receiver
GCK65_20550	COG3437	response regulator, receiver
GCK65_20560	COG0477	Major facilitator Superfamily
GCK65_20580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GCK65_20585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCK65_20585	COG1263	PTS System
GCK65_20605	COG0312	modulator of DNA gyrase
GCK65_20610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCK65_20620	COG3164	Protein of unknown function
GCK65_20625	COG1530	ribonuclease E activity
GCK65_20630	COG0424	maF-like protein
GCK65_20635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GCK65_20640	COG1792	Involved in formation and maintenance of cell shape
GCK65_20645	COG1077	Cell shape determining protein MreB Mrl
GCK65_20670	COG4968	Prepilin-type N-terminal cleavage methylation domain
GCK65_20675	COG2165	general secretion pathway protein
GCK65_20680	COG2165	general secretion pathway protein
GCK65_20690	COG1459	type II secretion system
GCK65_20695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCK65_20740	COG2200	EAL domain
GCK65_20740	COG2199	diguanylate cyclase activity
GCK65_20745	COG2200	EAL domain
GCK65_20750	COG0387	Pfam Sodium calcium exchanger
GCK65_20755	COG2986	histidine ammonia-lyase
GCK65_20760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GCK65_20765	COG0010	Belongs to the arginase family
GCK65_20770	COG1228	amidohydrolase
GCK65_20775	COG2188	Transcriptional regulator
GCK65_20780	COG0288	reversible hydration of carbon dioxide
GCK65_20790	COG2177	Part of the ABC transporter FtsEX involved in
GCK65_20795	COG2884	Cell division ATP-binding protein ftsE
GCK65_20800	COG0552	protein localization to endoplasmic reticulum
GCK65_20805	COG0742	ribosomal rna small subunit methyltransferase
GCK65_20835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCK65_20840	COG0741	lytic transglycosylase activity
GCK65_20850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCK65_20860	COG2095	MarC family integral membrane protein
GCK65_20870	COG1301	dicarboxylic acid transport
GCK65_20895	COG3714	YhhN family
GCK65_20920	COG1770	oligopeptidase
GCK65_20935	COG4221	oxidoreductase activity
GCK65_20940	COG0583	DNA-binding transcription factor activity
GCK65_20945	COG2249	NAD(P)H dehydrogenase (quinone) activity
GCK65_21005	COG0203	ribosomal protein L17
GCK65_21010	COG0202	RNA polymerase activity
GCK65_21015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GCK65_21020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GCK65_21025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCK65_21030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCK65_21035	COG0201	protein transport
GCK65_21040	COG0200	Binds to the 23S rRNA
GCK65_21045	COG1841	ribosomal large subunit assembly
GCK65_21050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GCK65_21055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GCK65_21060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GCK65_21065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GCK65_21070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GCK65_21075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GCK65_21080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GCK65_21085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GCK65_21090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GCK65_21095	COG0255	Belongs to the universal ribosomal protein uL29 family
GCK65_21100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GCK65_21105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GCK65_21110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GCK65_21115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GCK65_21120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCK65_21125	COG0089	rRNA binding
GCK65_21130	COG0088	Forms part of the polypeptide exit tunnel
GCK65_21135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GCK65_21140	COG0051	transcription antitermination factor activity, RNA binding
GCK65_21160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCK65_21165	COG2183	response to ionizing radiation
GCK65_21185	COG0596	Alpha beta hydrolase
GCK65_21190	COG1040	competence protein
GCK65_21195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GCK65_21195	COG0316	Belongs to the HesB IscA family
GCK65_21200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCK65_21205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GCK65_21210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCK65_21215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCK65_21220	COG4942	peptidase
GCK65_21230	COG1609	Transcriptional regulator
GCK65_21235	COG0800	Aldolase
GCK65_21240	COG0129	dihydroxy-acid dehydratase activity
GCK65_21245	COG3265	gluconokinase activity
GCK65_21250	COG2610	gluconate transmembrane transporter activity
GCK65_21255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCK65_21260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCK65_21270	COG0456	acetyltransferase
GCK65_21280	COG1490	D-aminoacyl-tRNA deacylase activity
GCK65_21285	COG1295	ribonuclease BN
GCK65_21290	COG1217	gtp-binding protein TYPA
GCK65_21295	COG0174	glutamine synthetase
GCK65_21305	COG3852	Histidine kinase
GCK65_21310	COG2204	response regulator
GCK65_21315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GCK65_21320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCK65_21330	COG3078	GTPase activator activity
GCK65_21345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GCK65_21355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCK65_21360	COG0408	coproporphyrinogen oxidase activity
GCK65_21365	COG0009	L-threonylcarbamoyladenylate synthase
GCK65_21375	COG0551	DNA topoisomerase type I activity
GCK65_21380	COG2922	Belongs to the Smg family
GCK65_21385	COG0758	DNA mediated transformation
GCK65_21395	COG0242	peptide deformylase activity
GCK65_21400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCK65_21405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCK65_21405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCK65_21410	COG0569	domain protein
GCK65_21415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCK65_21420	COG1322	Protein conserved in bacteria
GCK65_21440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCK65_21445	COG0686	Belongs to the AlaDH PNT family
GCK65_21450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GCK65_21450	COG0519	Catalyzes the synthesis of GMP from XMP
GCK65_21460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GCK65_21465	COG1396	sequence-specific DNA binding
GCK65_21470	COG1012	belongs to the aldehyde dehydrogenase family
GCK65_21480	COG2962	Rard protein
GCK65_21490	COG1280	lysine exporter protein (LysE YggA)
GCK65_21505	COG2391	methyltransferase activity
GCK65_21510	COG1280	lysine exporter protein (LysE YggA)
GCK65_21555	COG0583	DNA-binding transcription factor activity
GCK65_21585	COG0210	DNA helicase
GCK65_21590	COG1744	ABC transporter substrate-binding protein PnrA-like
GCK65_21595	COG3845	ABC transporter
GCK65_21600	COG4603	Belongs to the binding-protein-dependent transport system permease family
GCK65_21605	COG1079	Belongs to the binding-protein-dependent transport system permease family
GCK65_21610	COG0583	DNA-binding transcription factor activity
GCK65_21630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GCK65_21635	COG0385	Bile acid
GCK65_21640	COG0531	amino acid
GCK65_21645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCK65_21650	COG0531	amino acid
GCK65_21655	COG2731	YhcH YjgK YiaL family protein
GCK65_21660	COG3250	beta-galactosidase activity
GCK65_21665	COG1609	Transcriptional regulator
GCK65_21705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GCK65_21710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCK65_21710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCK65_21720	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GCK65_21725	COG3074	FtsZ-dependent cytokinesis
GCK65_21735	COG1045	serine acetyltransferase
GCK65_21745	COG0745	RESPONSE REGULATOR receiver
GCK65_21750	COG2205	protein histidine kinase activity
GCK65_21755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GCK65_21760	COG0534	Mate efflux family protein
GCK65_21785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCK65_21790	COG2937	Belongs to the GPAT DAPAT family
GCK65_21795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCK65_21800	COG3161	chorismate lyase activity
GCK65_21805	COG1580	Controls the rotational direction of flagella during chemotaxis
GCK65_21825	COG0604	alcohol dehydrogenase
GCK65_21830	COG1609	Transcriptional regulator
GCK65_21850	COG1519	Transferase
GCK65_21855	COG0859	PFAM glycosyl transferase family 9
GCK65_21860	COG0463	Glycosyl transferase, family 2
GCK65_21865	COG0859	PFAM glycosyl transferase family 9
GCK65_21870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GCK65_21875	COG2990	Protein conserved in bacteria
GCK65_21880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCK65_21890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GCK65_21895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GCK65_21900	COG2003	Belongs to the UPF0758 family
GCK65_21905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GCK65_21910	COG0756	dUTP diphosphatase activity
GCK65_21915	COG1309	transcriptional regulator
GCK65_21920	COG0668	transmembrane transport
GCK65_21935	COG0166	Belongs to the GPI family
GCK65_21940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GCK65_21945	COG0583	DNA-binding transcription factor activity
GCK65_21990	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GCK65_21995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCK65_22000	COG1739	Uncharacterized protein family UPF0029
GCK65_22005	COG0006	proline dipeptidase activity
GCK65_22010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCK65_22015	COG1024	Enoyl-CoA hydratase
GCK65_22015	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCK65_22020	COG0183	Belongs to the thiolase family
GCK65_22045	COG0425	Belongs to the sulfur carrier protein TusA family
GCK65_22050	COG0251	oxidation-reduction process
GCK65_22055	COG2885	chlorophyll binding
GCK65_22065	COG2818	Glycosylase
GCK65_22070	COG0752	glycyl-tRNA synthetase alpha subunit
GCK65_22075	COG0751	glycine-tRNA ligase activity
GCK65_22090	COG0529	Catalyzes the synthesis of activated sulfate
GCK65_22090	COG2046	Belongs to the sulfate adenylyltransferase family
GCK65_22110	COG0814	amino acid
GCK65_22115	COG0348	domain, Protein
GCK65_22125	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCK65_22130	COG0426	domain, Protein
GCK65_22130	COG1773	rubredoxin
GCK65_22135	COG3604	Transcriptional regulator
GCK65_22140	COG2188	Transcriptional regulator
GCK65_22155	COG1609	Transcriptional regulator
GCK65_22195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCK65_22220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCK65_22235	COG3118	belongs to the thioredoxin family
GCK65_22240	COG0513	Belongs to the DEAD box helicase family
GCK65_22245	COG0248	Ppx GppA phosphatase
GCK65_22260	COG0742	ribosomal rna small subunit methyltransferase
GCK65_22280	COG0084	hydrolase, TatD family'
GCK65_22285	COG0805	protein transport
GCK65_22290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCK65_22300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GCK65_22305	COG3165	ubiquinone biosynthetic process from chorismate
GCK65_22315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GCK65_22320	COG0402	S-adenosylhomocysteine deaminase activity
GCK65_22335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GCK65_22340	COG0848	biopolymer transport protein
GCK65_22345	COG0811	peptide transport
GCK65_22350	COG0811	peptide transport
GCK65_22360	COG2771	luxR family
GCK65_22365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GCK65_22370	COG1349	DNA-binding transcription factor activity
GCK65_22375	COG0745	RESPONSE REGULATOR receiver
GCK65_22380	COG2205	protein histidine kinase activity
GCK65_22390	COG4452	Inner membrane protein CreD
GCK65_22395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCK65_22400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GCK65_22405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GCK65_22410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GCK65_22415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GCK65_22420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GCK65_22425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GCK65_22435	COG0356	it plays a direct role in the translocation of protons across the membrane
GCK65_22445	COG1475	DNA binding
GCK65_22450	COG1192	Involved in chromosome partitioning
GCK65_22455	COG0357	Ribosomal RNA small subunit methyltransferase G
GCK65_22460	COG0445	tRNA wobble uridine modification
GCK65_22465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GCK65_22470	COG4774	siderophore transport
GCK65_22475	COG4615	Cyclic peptide transporter
GCK65_22480	COG1120	ATPase activity
GCK65_22495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GCK65_22500	COG0706	membrane insertase activity
GCK65_22505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GCK65_22510	COG0594	ribonuclease P activity
GCK65_22515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GCK65_22520	COG1126	abc transporter atp-binding protein