locus-tag	class	description
NRZ28_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NRZ28_00010	COG0592	DNA-directed DNA polymerase activity
NRZ28_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NRZ28_00030	COG2378	regulation of single-species biofilm formation
NRZ28_00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRZ28_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
NRZ28_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
NRZ28_00055	COG3977	Valine--pyruvate aminotransferase
NRZ28_00070	COG2814	Major facilitator Superfamily
NRZ28_00075	COG0745	RESPONSE REGULATOR receiver
NRZ28_00080	COG2205	protein histidine kinase activity
NRZ28_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRZ28_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_00105	COG4191	Histidine kinase
NRZ28_00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ28_00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_00120	COG1309	transcriptional regulator
NRZ28_00150	COG0469	pyruvate kinase activity
NRZ28_00155	COG2271	Major facilitator Superfamily
NRZ28_00180	COG0561	phosphatase activity
NRZ28_00185	COG2267	carboxylic ester hydrolase activity
NRZ28_00195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRZ28_00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRZ28_00205	COG1758	RNA polymerase activity
NRZ28_00215	COG0859	PFAM glycosyl transferase family 9
NRZ28_00220	COG3642	lipopolysaccharide core region biosynthetic process
NRZ28_00260	COG0589	response to stress
NRZ28_00270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRZ28_00280	COG1528	Iron-storage protein
NRZ28_00285	COG2081	HI0933 family
NRZ28_00290	COG2223	nitrite transmembrane transporter activity
NRZ28_00305	COG3121	Chaperone
NRZ28_00310	COG3188	usher protein
NRZ28_00320	COG3121	Chaperone
NRZ28_00330	COG2197	response regulator
NRZ28_00335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_00335	COG2205	protein histidine kinase activity
NRZ28_00350	COG1280	lysine exporter protein (LysE YggA)
NRZ28_00365	COG3188	usher protein
NRZ28_00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_00395	COG2205	protein histidine kinase activity
NRZ28_00405	COG3275	phosphorelay sensor kinase activity
NRZ28_00410	COG3279	Response regulator of the LytR AlgR family
NRZ28_00415	COG2223	nitrite transmembrane transporter activity
NRZ28_00420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRZ28_00425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRZ28_00440	COG0583	DNA-binding transcription factor activity
NRZ28_00450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NRZ28_00485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NRZ28_00490	COG2166	iron-sulfur cluster assembly
NRZ28_00495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRZ28_00500	COG0210	DNA helicase
NRZ28_00510	COG3245	cytochrome
NRZ28_00515	COG1063	alcohol dehydrogenase
NRZ28_00520	COG0156	8-amino-7-oxononanoate synthase activity
NRZ28_00530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ28_00545	COG3306	glycosyltransferase involved in LPS biosynthesis
NRZ28_00565	COG4774	siderophore transport
NRZ28_00570	COG4607	ABC-type enterochelin transport system periplasmic component
NRZ28_00575	COG4604	ABC transporter, ATP-binding protein
NRZ28_00580	COG4605	iron ion homeostasis
NRZ28_00585	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ28_00590	COG1132	(ABC) transporter
NRZ28_00595	COG2375	cellular response to nickel ion
NRZ28_00595	COG1132	(ABC) transporter
NRZ28_00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ28_00625	COG0076	glutamate decarboxylase activity
NRZ28_00630	COG1561	YicC-like family, N-terminal region
NRZ28_00635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NRZ28_00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRZ28_00655	COG2203	Gaf domain
NRZ28_00655	COG4251	negative regulation of phosphorylation
NRZ28_00655	COG5001	Diguanylate cyclase
NRZ28_00655	COG3706	GGDEF domain
NRZ28_00660	COG3084	Protein conserved in bacteria
NRZ28_00670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRZ28_00675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ28_00685	COG1335	isochorismatase
NRZ28_00695	COG1683	Conserved Protein
NRZ28_00700	COG0204	Acyl-transferase
NRZ28_00705	COG0204	Acyl-transferase
NRZ28_00710	COG0606	chelatase, subunit chli
NRZ28_00720	COG3978	acetolactate synthase activity
NRZ28_00730	COG0129	dihydroxy-acid dehydratase activity
NRZ28_00750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRZ28_00755	COG0254	rRNA binding
NRZ28_00760	COG0702	epimerase
NRZ28_00765	COG0281	malic enzyme
NRZ28_00775	COG2205	protein histidine kinase activity
NRZ28_00780	COG0745	RESPONSE REGULATOR receiver
NRZ28_00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ28_00820	COG4310	Domain of unknown function (DUF2172)
NRZ28_00840	COG2089	acid synthase
NRZ28_00850	COG1083	cytidylyl-transferase
NRZ28_00865	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_00870	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ28_00885	COG1215	transferase activity, transferring glycosyl groups
NRZ28_00890	COG0562	UDP-galactopyranose mutase
NRZ28_00925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ28_00930	COG0367	asparagine synthase
NRZ28_00940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ28_00945	COG1086	Polysaccharide biosynthesis protein
NRZ28_00950	COG0366	Alpha amylase catalytic
NRZ28_00965	COG0443	Heat shock 70 kDa protein
NRZ28_00970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRZ28_00975	COG3045	CreA protein
NRZ28_00995	COG0174	glutamine synthetase
NRZ28_01015	COG3842	ATPase activity
NRZ28_01020	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRZ28_01025	COG1177	transmembrane transport
NRZ28_01030	COG2258	MOSC domain
NRZ28_01045	COG2050	protein possibly involved in aromatic compounds catabolism
NRZ28_01050	COG0514	ATP-dependent DNA helicase (RecQ)
NRZ28_01060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NRZ28_01070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NRZ28_01075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRZ28_01085	COG2239	Acts as a magnesium transporter
NRZ28_01090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRZ28_01090	COG1648	precorrin-2 dehydrogenase activity
NRZ28_01095	COG2116	formate transmembrane transporter activity
NRZ28_01110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRZ28_01115	COG0842	Transport permease protein
NRZ28_01120	COG0842	Transport permease protein
NRZ28_01125	COG1131	(ABC) transporter
NRZ28_01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_01140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NRZ28_01145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NRZ28_01165	COG1595	DNA-templated transcription, initiation
NRZ28_01170	COG3806	Anti-sigma factor
NRZ28_01175	COG1968	undecaprenyl-diphosphatase activity
NRZ28_01180	COG0667	Aldo Keto reductase
NRZ28_01185	COG2017	converts alpha-aldose to the beta-anomer
NRZ28_01190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRZ28_01200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRZ28_01205	COG1609	Transcriptional regulator
NRZ28_01210	COG3250	beta-galactosidase activity
NRZ28_01230	COG0840	transmembrane signaling receptor activity
NRZ28_01260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRZ28_01265	COG1288	antiporter activity
NRZ28_01270	COG1438	arginine binding
NRZ28_01275	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NRZ28_01280	COG0540	Belongs to the ATCase OTCase family
NRZ28_01300	COG0688	phosphatidylethanolamine metabolic process
NRZ28_01310	COG3040	lipid binding
NRZ28_01315	COG2207	Transcriptional regulator
NRZ28_01320	COG1979	alcohol dehydrogenase
NRZ28_01325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NRZ28_01330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NRZ28_01340	COG3681	Belongs to the UPF0597 family
NRZ28_01350	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ28_01355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ28_01360	COG0564	pseudouridine synthase activity
NRZ28_01370	COG0542	response to heat
NRZ28_01375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRZ28_01380	COG2502	aspartate--ammonia ligase
NRZ28_01385	COG1522	sequence-specific DNA binding
NRZ28_01395	COG5413	integral membrane protein
NRZ28_01420	COG2205	protein histidine kinase activity
NRZ28_01430	COG2204	response regulator
NRZ28_01445	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NRZ28_01475	COG0243	molybdopterin cofactor binding
NRZ28_01480	COG3005	denitrification pathway
NRZ28_01485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRZ28_01505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ28_01510	COG0569	domain protein
NRZ28_01515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRZ28_01540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRZ28_01555	COG0250	Participates in transcription elongation, termination and antitermination
NRZ28_01560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRZ28_01565	COG0081	regulation of translation
NRZ28_01570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRZ28_01575	COG0222	ribosome binding
NRZ28_01580	COG0085	RNA polymerase activity
NRZ28_01585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRZ28_01590	COG2964	Protein conserved in bacteria
NRZ28_01595	COG0251	oxidation-reduction process
NRZ28_01605	COG2923	Belongs to the DsrF TusC family
NRZ28_01610	COG2168	tRNA wobble position uridine thiolation
NRZ28_01615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRZ28_01620	COG0049	tRNA binding
NRZ28_01625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRZ28_01630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRZ28_01635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRZ28_01670	COG2252	PERMEase
NRZ28_01675	COG2376	Dihydroxyacetone kinase
NRZ28_01680	COG1461	Dihydroxyacetone kinase
NRZ28_01695	COG3284	Transcriptional regulator
NRZ28_01700	COG2957	Belongs to the agmatine deiminase family
NRZ28_01710	COG0628	permease
NRZ28_01715	COG0494	nUDIX hydrolase
NRZ28_01740	COG0753	catalase activity
NRZ28_01745	COG1247	-acetyltransferase
NRZ28_01765	COG2203	Gaf domain
NRZ28_01765	COG2199	diguanylate cyclase activity
NRZ28_01775	COG3842	ATPase activity
NRZ28_01785	COG1175	transmembrane transport
NRZ28_01810	COG0583	DNA-binding transcription factor activity
NRZ28_01820	COG1741	Belongs to the pirin family
NRZ28_01825	COG2259	Doxx family
NRZ28_01830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NRZ28_01835	COG1074	ATP-dependent DNA helicase activity
NRZ28_01840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRZ28_01850	COG0346	lactoylglutathione lyase activity
NRZ28_01890	COG3706	GGDEF domain
NRZ28_01895	COG4771	TonB-dependent receptor
NRZ28_01900	COG1278	Cold shock
NRZ28_01925	COG0629	single-stranded DNA binding
NRZ28_01930	COG2197	response regulator
NRZ28_01935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRZ28_01975	COG3135	benzoate transporter
NRZ28_01980	COG1396	sequence-specific DNA binding
NRZ28_02010	COG2926	Belongs to the UPF0265 family
NRZ28_02020	COG3028	Belongs to the UPF0307 family
NRZ28_02025	COG0312	modulator of DNA gyrase
NRZ28_02030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRZ28_02035	COG5007	Belongs to the BolA IbaG family
NRZ28_02045	COG2854	intermembrane phospholipid transfer
NRZ28_02050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRZ28_02055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NRZ28_02060	COG1127	ABC transporter
NRZ28_02065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRZ28_02065	COG0517	IMP dehydrogenase activity
NRZ28_02070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NRZ28_02075	COG3117	lipopolysaccharide transmembrane transporter activity
NRZ28_02080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NRZ28_02085	COG1137	ATPase activity
NRZ28_02090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NRZ28_02100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_02105	COG1660	Displays ATPase and GTPase activities
NRZ28_02110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_02115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_02115	COG3711	transcriptional antiterminator
NRZ28_02130	COG3964	amidohydrolase
NRZ28_02160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRZ28_02165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRZ28_02175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NRZ28_02180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NRZ28_02185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRZ28_02190	COG0723	plastoquinol--plastocyanin reductase activity
NRZ28_02195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRZ28_02200	COG2857	Cytochrome c1
NRZ28_02205	COG0625	glutathione transferase activity
NRZ28_02210	COG2969	positive regulation of protein catabolic process
NRZ28_02215	COG2823	Periplasmic or secreted lipoprotein
NRZ28_02220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRZ28_02225	COG0792	nuclease activity
NRZ28_02230	COG3107	peptidoglycan biosynthetic process
NRZ28_02235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRZ28_02245	COG2001	Belongs to the MraZ family
NRZ28_02250	COG0275	rRNA processing
NRZ28_02255	COG3116	cell division
NRZ28_02260	COG0768	penicillin binding
NRZ28_02270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRZ28_02275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRZ28_02280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRZ28_02285	COG0772	Belongs to the SEDS family
NRZ28_02290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRZ28_02295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRZ28_02300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRZ28_02305	COG0849	cell division
NRZ28_02310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NRZ28_02315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NRZ28_02325	COG0653	protein targeting
NRZ28_02335	COG0494	nUDIX hydrolase
NRZ28_02340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NRZ28_02345	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NRZ28_02360	COG1459	type II secretion system
NRZ28_02365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ28_02390	COG2186	Transcriptional regulator
NRZ28_02395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRZ28_02400	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRZ28_02405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRZ28_02415	COG0840	transmembrane signaling receptor activity
NRZ28_02420	COG0840	transmembrane signaling receptor activity
NRZ28_02425	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRZ28_02430	COG1049	propionate catabolic process, 2-methylcitrate cycle
NRZ28_02440	COG1280	lysine exporter protein (LysE YggA)
NRZ28_02450	COG0523	cobalamin synthesis protein
NRZ28_02455	COG0477	Major facilitator Superfamily
NRZ28_02470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRZ28_02475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NRZ28_02510	COG3314	Sporulation integral membrane protein YlbJ
NRZ28_02515	COG0835	chemotaxis
NRZ28_02515	COG0784	Response regulator, receiver
NRZ28_02525	COG1444	tRNA N-acetyltransferase activity
NRZ28_02550	COG1803	Methylglyoxal synthase
NRZ28_02565	COG0252	asparaginase activity
NRZ28_02585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_02585	COG1263	PTS System
NRZ28_02590	COG0366	Alpha amylase catalytic
NRZ28_02595	COG0110	maltose O-acetyltransferase activity
NRZ28_02605	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_02610	COG1177	transmembrane transport
NRZ28_02615	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRZ28_02620	COG3842	ATPase activity
NRZ28_02625	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NRZ28_02630	COG0583	DNA-binding transcription factor activity
NRZ28_02635	COG1757	Na H antiporter
NRZ28_02655	COG0297	glycogen (starch) synthase activity
NRZ28_02660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ28_02665	COG2813	Specifically methylates the guanine in position
NRZ28_02670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRZ28_02675	COG2203	Gaf domain
NRZ28_02675	COG3706	GGDEF domain
NRZ28_02675	COG4251	negative regulation of phosphorylation
NRZ28_02675	COG5001	Diguanylate cyclase
NRZ28_02685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_02695	COG2995	paraquat-inducible protein a
NRZ28_02700	COG3008	intermembrane lipid transfer
NRZ28_02700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRZ28_02705	COG3009	Protein conserved in bacteria
NRZ28_02720	COG3240	lipase activity
NRZ28_02725	COG3111	PFAM Bacterial OB fold (BOF) protein
NRZ28_02735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NRZ28_02740	COG1194	a g-specific adenine glycosylase
NRZ28_02750	COG3267	Type II secretory pathway component ExeA
NRZ28_02750	COG3409	Peptidoglycan-binding domain 1 protein
NRZ28_02755	COG0617	tRNA 3'-terminal CCA addition
NRZ28_02770	COG1346	cytolysis
NRZ28_02775	COG1380	Effector of murein hydrolase LrgA
NRZ28_02780	COG0583	DNA-binding transcription factor activity
NRZ28_02815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRZ28_02820	COG0306	phosphate transporter
NRZ28_02825	COG1392	Phosphate transport regulator
NRZ28_02840	COG1560	Kdo2-lipid A biosynthetic process
NRZ28_02845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRZ28_02845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NRZ28_02850	COG1538	Outer membrane efflux protein
NRZ28_02855	COG0494	nUDIX hydrolase
NRZ28_02860	COG3151	Protein conserved in bacteria
NRZ28_02870	COG3150	esterase
NRZ28_02875	COG1051	belongs to the nudix hydrolase family
NRZ28_02890	COG1566	PFAM secretion protein HlyD family protein
NRZ28_02895	COG1289	transmembrane transporter activity
NRZ28_02915	COG0583	DNA-binding transcription factor activity
NRZ28_02955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ28_02975	COG0204	Acyl-transferase
NRZ28_02980	COG1842	Phage shock protein A
NRZ28_02995	COG2827	Endonuclease containing a URI domain
NRZ28_03005	COG2962	Rard protein
NRZ28_03010	COG1573	uracil-dna glycosylase
NRZ28_03015	COG0697	spore germination
NRZ28_03020	COG0583	DNA-binding transcription factor activity
NRZ28_03025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRZ28_03030	COG1121	(ABC) transporter
NRZ28_03035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NRZ28_03055	COG0739	heme binding
NRZ28_03065	COG3068	Protein conserved in bacteria
NRZ28_03085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NRZ28_03090	COG1546	Belongs to the CinA family
NRZ28_03095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRZ28_03105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRZ28_03110	COG0527	aspartate kinase activity
NRZ28_03115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NRZ28_03150	COG1686	Belongs to the peptidase S11 family
NRZ28_03155	COG0586	Pfam SNARE associated Golgi protein
NRZ28_03160	COG1253	flavin adenine dinucleotide binding
NRZ28_03165	COG0525	valine-tRNA ligase activity
NRZ28_03170	COG2927	DNA polymerase III (CHI subunit)
NRZ28_03175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ28_03180	COG0795	lipopolysaccharide-transporting ATPase activity
NRZ28_03185	COG0795	lipopolysaccharide-transporting ATPase activity
NRZ28_03200	COG0004	ammonium transporteR
NRZ28_03205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ28_03215	COG2165	general secretion pathway protein
NRZ28_03220	COG0084	hydrolase, TatD family'
NRZ28_03225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ28_03235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRZ28_03240	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRZ28_03245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRZ28_03250	COG0813	purine-nucleoside phosphorylase activity
NRZ28_03255	COG5002	protein histidine kinase activity
NRZ28_03255	COG5001	Diguanylate cyclase
NRZ28_03255	COG3447	MASE1 domain protein
NRZ28_03265	COG0560	Phosphoserine phosphatase
NRZ28_03290	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NRZ28_03300	COG0776	regulation of translation
NRZ28_03315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRZ28_03320	COG0735	belongs to the Fur family
NRZ28_03345	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRZ28_03350	COG0513	Belongs to the DEAD box helicase family
NRZ28_03355	COG3022	response to hydroperoxide
NRZ28_03370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRZ28_03375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRZ28_03380	COG0762	integral membrane protein
NRZ28_03385	COG1872	DUF167
NRZ28_03400	COG4166	transmembrane transport
NRZ28_03420	COG1024	Enoyl-CoA hydratase
NRZ28_03435	COG4221	oxidoreductase activity
NRZ28_03440	COG0442	prolyl-tRNA aminoacylation
NRZ28_03445	COG0840	transmembrane signaling receptor activity
NRZ28_03450	COG0632	four-way junction helicase activity
NRZ28_03455	COG2255	four-way junction helicase activity
NRZ28_03460	COG1271	oxidase subunit
NRZ28_03465	COG1294	oxidase, subunit
NRZ28_03470	COG4890	Cyd operon protein YbgT
NRZ28_03475	COG3790	cyd operon protein YbgE
NRZ28_03480	COG0824	Thioesterase
NRZ28_03485	COG0811	peptide transport
NRZ28_03500	COG0823	Involved in the tonB-independent uptake of proteins
NRZ28_03505	COG2885	chlorophyll binding
NRZ28_03510	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NRZ28_03545	COG0840	transmembrane signaling receptor activity
NRZ28_03550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NRZ28_03555	COG0676	glucose-6-phosphate 1-epimerase activity
NRZ28_03560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRZ28_03565	COG1640	4-alpha-glucanotransferase
NRZ28_03570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NRZ28_03590	COG1051	belongs to the nudix hydrolase family
NRZ28_03595	COG2130	NADP-dependent
NRZ28_03600	COG1764	response to oxidative stress
NRZ28_03605	COG1846	Transcriptional regulator
NRZ28_03640	COG0561	phosphatase activity
NRZ28_03655	COG0733	neurotransmitter:sodium symporter activity
NRZ28_03665	COG0733	neurotransmitter:sodium symporter activity
NRZ28_03690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ28_03705	COG1794	racemase activity, acting on amino acids and derivatives
NRZ28_03710	COG2132	Multicopper oxidase
NRZ28_03710	COG2132	Multicopper oxidase
NRZ28_03720	COG2731	YhcH YjgK YiaL family protein
NRZ28_03730	COG0668	transmembrane transport
NRZ28_03740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRZ28_03750	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRZ28_03770	COG0583	DNA-binding transcription factor activity
NRZ28_03775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NRZ28_03785	COG0488	(ABC) transporter
NRZ28_03790	COG0517	IMP dehydrogenase activity
NRZ28_03790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRZ28_03795	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRZ28_03800	COG0330	HflC and HflK could
NRZ28_03805	COG1648	precorrin-2 dehydrogenase activity
NRZ28_03805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRZ28_03810	COG0175	sulfate reduction
NRZ28_03815	COG2895	sulfate adenylyltransferase (ATP) activity
NRZ28_03820	COG0471	metal ion transport
NRZ28_03820	COG3273	potassium ion transport
NRZ28_03825	COG0529	Catalyzes the synthesis of activated sulfate
NRZ28_03845	COG0625	glutathione transferase activity
NRZ28_03880	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NRZ28_03895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NRZ28_03900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRZ28_03905	COG0163	prenyltransferase activity
NRZ28_03920	COG1131	(ABC) transporter
NRZ28_03925	COG0842	Transport permease protein
NRZ28_03930	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NRZ28_03935	COG1924	4 iron, 4 sulfur cluster binding
NRZ28_03955	COG1823	symporter activity
NRZ28_03960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NRZ28_03965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NRZ28_03970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NRZ28_03980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ28_03985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRZ28_03990	COG1489	DNA binding
NRZ28_04000	COG1643	Atp-dependent helicase
NRZ28_04005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRZ28_04010	COG0346	lactoylglutathione lyase activity
NRZ28_04020	COG2076	Multidrug Resistance protein
NRZ28_04030	COG0784	Response regulator, receiver
NRZ28_04030	COG3437	response regulator, receiver
NRZ28_04040	COG0671	phosphoesterase, PA-phosphatase related
NRZ28_04055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NRZ28_04060	COG0038	chloride channel
NRZ28_04070	COG0316	Belongs to the HesB IscA family
NRZ28_04095	COG1280	lysine exporter protein (LysE YggA)
NRZ28_04100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NRZ28_04115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_04145	COG0745	RESPONSE REGULATOR receiver
NRZ28_04150	COG3104	oligopeptide transport
NRZ28_04155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRZ28_04160	COG1555	photosystem II stabilization
NRZ28_04170	COG2350	Protein conserved in bacteria
NRZ28_04175	COG2917	probably involved in intracellular septation
NRZ28_04180	COG0076	glutamate decarboxylase activity
NRZ28_04185	COG1272	protein, Hemolysin III
NRZ28_04190	COG0569	domain protein
NRZ28_04190	COG2985	domain, Protein
NRZ28_04250	COG0784	Response regulator, receiver
NRZ28_04250	COG0835	chemotaxis
NRZ28_04255	COG2755	lipolytic protein G-D-S-L family
NRZ28_04260	COG4181	ATPase activity
NRZ28_04265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NRZ28_04270	COG1090	epimerase
NRZ28_04275	COG2200	EAL domain
NRZ28_04280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ28_04285	COG2234	aminopeptidase activity
NRZ28_04285	COG4935	Belongs to the peptidase S8 family
NRZ28_04290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRZ28_04295	COG3171	Protein conserved in bacteria
NRZ28_04300	COG2066	Belongs to the glutaminase family
NRZ28_04305	COG2897	thiosulfate sulfurtransferase activity
NRZ28_04315	COG1132	(ABC) transporter
NRZ28_04345	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRZ28_04350	COG5001	Diguanylate cyclase
NRZ28_04350	COG3300	MHYT domain
NRZ28_04370	COG4628	conserved protein (DUF2132)
NRZ28_04375	COG0688	phosphatidylethanolamine metabolic process
NRZ28_04380	COG1162	GTPase activity
NRZ28_04385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NRZ28_04440	COG1278	Cold shock
NRZ28_04450	COG0840	transmembrane signaling receptor activity
NRZ28_04455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ28_04505	COG0848	biopolymer transport protein
NRZ28_04510	COG0811	peptide transport
NRZ28_04515	COG0811	peptide transport
NRZ28_04530	COG4174	ABC transporter (Permease)
NRZ28_04535	COG4239	(ABC) transporter, permease
NRZ28_04545	COG0444	Belongs to the ABC transporter superfamily
NRZ28_04550	COG4608	Belongs to the ABC transporter superfamily
NRZ28_04555	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRZ28_04560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NRZ28_04565	COG1073	alpha beta
NRZ28_04580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NRZ28_04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ28_04620	COG2313	pseudouridylate synthase activity
NRZ28_04630	COG1858	cytochrome C peroxidase
NRZ28_04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ28_04670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ28_04695	COG2986	histidine ammonia-lyase
NRZ28_04730	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_04735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRZ28_04745	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRZ28_04755	COG2966	Psort location CytoplasmicMembrane, score
NRZ28_04760	COG3610	response to peptide
NRZ28_04770	COG4175	Glycine betaine
NRZ28_04775	COG4176	ABC-type proline glycine betaine transport system permease component
NRZ28_04780	COG2113	Glycine betaine
NRZ28_04785	COG0175	sulfate reduction
NRZ28_04790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRZ28_04795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRZ28_04800	COG0384	phenazine biosynthesis protein PhzF
NRZ28_04805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRZ28_04820	COG0786	glutamate:sodium symporter activity
NRZ28_04825	COG0252	asparaginase activity
NRZ28_04830	COG3139	Protein of unknown function (DUF1315)
NRZ28_04850	COG0616	signal peptide processing
NRZ28_04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ28_04855	COG1902	pentaerythritol trinitrate reductase activity
NRZ28_04860	COG0778	Nitroreductase
NRZ28_04880	COG2264	protein methyltransferase activity
NRZ28_04885	COG0604	alcohol dehydrogenase
NRZ28_04890	COG0583	DNA-binding transcription factor activity
NRZ28_04895	COG2190	(PTS) system
NRZ28_04895	COG1263	PTS System
NRZ28_04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_04900	COG4145	pantothenate transmembrane transporter activity
NRZ28_04910	COG0439	Biotin carboxylase
NRZ28_04915	COG0511	ligase activity, forming carbon-carbon bonds
NRZ28_04920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NRZ28_04925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRZ28_04935	COG5001	Diguanylate cyclase
NRZ28_04935	COG3300	MHYT domain
NRZ28_04955	COG3381	protein complex oligomerization
NRZ28_04970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRZ28_04985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NRZ28_04990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRZ28_04990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRZ28_05010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NRZ28_05015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ28_05020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NRZ28_05025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRZ28_05030	COG4172	Belongs to the ABC transporter superfamily
NRZ28_05040	COG0601	transmembrane transport
NRZ28_05050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRZ28_05055	COG0142	geranyltranstransferase activity
NRZ28_05060	COG1722	exodeoxyribonuclease VII activity
NRZ28_05065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ28_05070	COG1360	Flagellar Motor Protein
NRZ28_05085	COG1534	Rna-binding protein
NRZ28_05090	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NRZ28_05100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRZ28_05105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRZ28_05110	COG0149	triose-phosphate isomerase activity
NRZ28_05115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRZ28_05130	COG0779	Required for maturation of 30S ribosomal subunits
NRZ28_05135	COG0195	Participates in both transcription termination and antitermination
NRZ28_05140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NRZ28_05145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRZ28_05150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRZ28_05155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRZ28_05160	COG1185	polyribonucleotide nucleotidyltransferase activity
NRZ28_05165	COG2211	Major facilitator Superfamily
NRZ28_05170	COG3706	GGDEF domain
NRZ28_05175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NRZ28_05185	COG0114	fumarate hydratase activity
NRZ28_05195	COG1966	Carbon starvation protein
NRZ28_05200	COG3279	Response regulator of the LytR AlgR family
NRZ28_05205	COG3275	phosphorelay sensor kinase activity
NRZ28_05280	COG0312	modulator of DNA gyrase
NRZ28_05285	COG0312	modulator of DNA gyrase
NRZ28_05295	COG4974	Belongs to the 'phage' integrase family
NRZ28_05300	COG1970	mechanosensitive ion channel activity
NRZ28_05305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ28_05315	COG0789	Transcriptional regulator
NRZ28_05330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ28_05335	COG3545	Serine hydrolase
NRZ28_05405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NRZ28_05410	COG0321	lipoyl(octanoyl) transferase activity
NRZ28_05415	COG2921	Belongs to the UPF0250 family
NRZ28_05420	COG1686	Belongs to the peptidase S11 family
NRZ28_05425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRZ28_05430	COG2951	lytic endotransglycosylase activity
NRZ28_05435	COG0772	Belongs to the SEDS family
NRZ28_05440	COG0768	penicillin binding
NRZ28_05445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NRZ28_05450	COG0799	negative regulation of ribosome biogenesis
NRZ28_05455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRZ28_05470	COG0495	leucyl-tRNA aminoacylation
NRZ28_05475	COG2888	peptidyl-tyrosine sulfation
NRZ28_05480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NRZ28_05485	COG4535	Mg2 and Co2 transporter CorC
NRZ28_05490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRZ28_05495	COG1702	phosphate starvation-inducible protein PhoH
NRZ28_05500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRZ28_05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ28_05510	COG1335	isochorismatase
NRZ28_05520	COG3706	GGDEF domain
NRZ28_05525	COG0583	DNA-binding transcription factor activity
NRZ28_05535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_05555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRZ28_05565	COG3647	Membrane
NRZ28_05570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRZ28_05580	COG0516	GMP reductase activity
NRZ28_05590	COG0642	Histidine kinase
NRZ28_05630	COG3214	Protein conserved in bacteria
NRZ28_05655	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NRZ28_05660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRZ28_05665	COG1053	succinate dehydrogenase
NRZ28_05675	COG0584	glycerophosphoryl diester phosphodiesterase
NRZ28_05680	COG1511	domain protein
NRZ28_05680	COG3264	Mechanosensitive ion channel
NRZ28_05690	COG0739	heme binding
NRZ28_05705	COG0583	DNA-binding transcription factor activity
NRZ28_05720	COG0840	transmembrane signaling receptor activity
NRZ28_05725	COG0583	DNA-binding transcription factor activity
NRZ28_05730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NRZ28_05760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRZ28_05765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NRZ28_05775	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NRZ28_05785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRZ28_05795	COG0180	Tryptophanyl-tRNA synthetase
NRZ28_05810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRZ28_05820	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_05830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_05840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_05840	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRZ28_05840	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRZ28_05840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRZ28_05850	COG0366	Alpha amylase catalytic
NRZ28_05880	COG0471	metal ion transport
NRZ28_05880	COG0490	domain, Protein
NRZ28_05915	COG0012	GTP binding
NRZ28_05920	COG0193	aminoacyl-tRNA hydrolase activity
NRZ28_05925	COG0737	Belongs to the 5'-nucleotidase family
NRZ28_05930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRZ28_05940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NRZ28_05945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NRZ28_05950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NRZ28_05955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRZ28_05960	COG2890	protein-(glutamine-N5) methyltransferase activity
NRZ28_05970	COG2912	Transglutaminase-like superfamily
NRZ28_05975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NRZ28_05980	COG1301	dicarboxylic acid transport
NRZ28_05990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRZ28_06005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRZ28_06010	COG1115	amino acid carrier protein
NRZ28_06025	COG0714	Associated with various cellular activities
NRZ28_06035	COG3104	oligopeptide transport
NRZ28_06040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRZ28_06045	COG1678	Uncharacterized ACR, COG1678
NRZ28_06060	COG0189	ligase activity
NRZ28_06065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRZ28_06075	COG3091	SprT-like family
NRZ28_06085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NRZ28_06105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRZ28_06110	COG0739	heme binding
NRZ28_06115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRZ28_06120	COG3408	Glycogen debranching enzyme
NRZ28_06120	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NRZ28_06130	COG1881	PFAM PEBP family protein
NRZ28_06135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRZ28_06140	COG0583	DNA-binding transcription factor activity
NRZ28_06150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRZ28_06160	COG0583	DNA-binding transcription factor activity
NRZ28_06165	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_06170	COG0616	signal peptide processing
NRZ28_06175	COG3724	N-succinylarginine dihydrolase activity
NRZ28_06195	COG0840	transmembrane signaling receptor activity
NRZ28_06205	COG2971	BadF BadG BcrA BcrD
NRZ28_06215	COG4608	Belongs to the ABC transporter superfamily
NRZ28_06220	COG0444	Belongs to the ABC transporter superfamily
NRZ28_06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ28_06230	COG0601	transmembrane transport
NRZ28_06235	COG4166	transmembrane transport
NRZ28_06240	COG0784	Response regulator, receiver
NRZ28_06240	COG2205	protein histidine kinase activity
NRZ28_06270	COG3220	belongs to the UPF0276 family
NRZ28_06305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ28_06310	COG1289	transmembrane transporter activity
NRZ28_06315	COG0303	'Molybdopterin
NRZ28_06320	COG0746	molybdenum cofactor guanylyltransferase activity
NRZ28_06330	COG4662	Binding-protein-dependent transport system inner membrane component
NRZ28_06340	COG2204	response regulator
NRZ28_06345	COG3852	Histidine kinase
NRZ28_06350	COG1910	domain protein
NRZ28_06355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRZ28_06390	COG3383	formate dehydrogenase (NAD+) activity
NRZ28_06390	COG3383	formate dehydrogenase (NAD+) activity
NRZ28_06395	COG0437	4 iron, 4 sulfur cluster binding
NRZ28_06410	COG0281	malic enzyme
NRZ28_06430	COG2706	6-phosphogluconolactonase activity
NRZ28_06440	COG1196	nuclear chromosome segregation
NRZ28_06440	COG3264	Mechanosensitive ion channel
NRZ28_06445	COG0469	pyruvate kinase activity
NRZ28_06460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRZ28_06460	COG4651	solute:proton antiporter activity
NRZ28_06470	COG2974	May be involved in recombination
NRZ28_06480	COG0420	3'-5' exonuclease activity
NRZ28_06485	COG0419	ATPase involved in DNA repair
NRZ28_06495	COG3038	cytochrome b561
NRZ28_06510	COG2190	(PTS) system
NRZ28_06520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_06525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRZ28_06530	COG0542	response to heat
NRZ28_06545	COG2770	Histidine kinase
NRZ28_06545	COG3437	response regulator, receiver
NRZ28_06550	COG1720	tRNA m6t6A37 methyltransferase activity
NRZ28_06570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NRZ28_06575	COG4988	ABC transporter
NRZ28_06590	COG0745	RESPONSE REGULATOR receiver
NRZ28_06600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRZ28_06615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NRZ28_06620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NRZ28_06630	COG0083	homoserine kinase activity
NRZ28_06635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRZ28_06640	COG4319	ketosteroid isomerase
NRZ28_06655	COG0488	(ABC) transporter
NRZ28_06670	COG0813	purine-nucleoside phosphorylase activity
NRZ28_06685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_06685	COG2205	protein histidine kinase activity
NRZ28_06690	COG3384	dioxygenase
NRZ28_06700	COG1283	sodium-dependent phosphate transmembrane transporter activity
NRZ28_06710	COG0531	amino acid
NRZ28_06720	COG0531	amino acid
NRZ28_06740	COG1917	Cupin 2, conserved barrel domain protein
NRZ28_06740	COG1396	sequence-specific DNA binding
NRZ28_06745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ28_06775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ28_06780	COG2375	cellular response to nickel ion
NRZ28_06790	COG0577	efflux transmembrane transporter activity
NRZ28_06790	COG1136	(ABC) transporter
NRZ28_06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_06805	COG1227	inorganic diphosphatase activity
NRZ28_06810	COG0497	DNA recombination
NRZ28_06815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRZ28_06820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRZ28_06825	COG0443	Heat shock 70 kDa protein
NRZ28_06830	COG0484	heat shock protein binding
NRZ28_06860	COG1285	pathogenesis
NRZ28_06870	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ28_06910	COG0095	Lipoate-protein ligase
NRZ28_06930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ28_06935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_06955	COG0708	Exodeoxyribonuclease III
NRZ28_06970	COG2211	Major facilitator Superfamily
NRZ28_07015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRZ28_07020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRZ28_07025	COG1845	cytochrome c oxidase, subunit III
NRZ28_07030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NRZ28_07035	COG0109	protoheme IX farnesyltransferase activity
NRZ28_07040	COG2814	Major facilitator Superfamily
NRZ28_07050	COG2175	clavaminate synthase activity
NRZ28_07055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRZ28_07060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NRZ28_07065	COG4521	taurine ABC transporter
NRZ28_07075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ28_07095	COG1988	membrane-bound metal-dependent
NRZ28_07120	COG0159	tryptophan synthase activity
NRZ28_07125	COG0133	tryptophan synthase activity
NRZ28_07130	COG0134	indole-3-glycerol-phosphate synthase activity
NRZ28_07130	COG0135	phosphoribosylanthranilate isomerase activity
NRZ28_07135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRZ28_07140	COG0512	Glutamine amidotransferase of anthranilate synthase
NRZ28_07140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRZ28_07145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRZ28_07155	COG0009	L-threonylcarbamoyladenylate synthase
NRZ28_07165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRZ28_07175	COG1946	Acyl-CoA thioesterase
NRZ28_07190	COG1309	transcriptional regulator
NRZ28_07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ28_07215	COG1091	dTDP-4-dehydrorhamnose reductase activity
NRZ28_07230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ28_07235	COG0454	-acetyltransferase
NRZ28_07235	COG0456	acetyltransferase
NRZ28_07250	COG1215	transferase activity, transferring glycosyl groups
NRZ28_07255	COG2226	methyltransferase
NRZ28_07280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRZ28_07295	COG1940	carbohydrate kinase activity
NRZ28_07295	COG1846	Transcriptional regulator
NRZ28_07300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRZ28_07305	COG0363	glucosamine-6-phosphate deaminase activity
NRZ28_07310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_07310	COG1263	PTS System
NRZ28_07310	COG2190	(PTS) system
NRZ28_07320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ28_07325	COG0735	belongs to the Fur family
NRZ28_07335	COG0716	FMN binding
NRZ28_07350	COG0596	Alpha beta hydrolase
NRZ28_07355	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NRZ28_07360	COG0033	Phosphoglucomutase
NRZ28_07370	COG1846	Transcriptional regulator
NRZ28_07375	COG2951	lytic endotransglycosylase activity
NRZ28_07380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRZ28_07385	COG4136	ATPase activity
NRZ28_07395	COG4134	Bacterial extracellular solute-binding protein
NRZ28_07405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRZ28_07415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRZ28_07420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRZ28_07430	COG0729	surface antigen
NRZ28_07435	COG2911	Protein conserved in bacteria
NRZ28_07455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRZ28_07465	COG0741	lytic transglycosylase activity
NRZ28_07480	COG1607	acyl-coa hydrolase
NRZ28_07490	COG3021	interspecies interaction between organisms
NRZ28_07495	COG0741	lytic transglycosylase activity
NRZ28_07495	COG1388	LysM domain
NRZ28_07500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRZ28_07505	COG2226	methyltransferase
NRZ28_07510	COG0328	RNA-DNA hybrid ribonuclease activity
NRZ28_07525	COG0784	Response regulator, receiver
NRZ28_07525	COG3437	response regulator, receiver
NRZ28_07530	COG1960	acyl-CoA dehydrogenase activity
NRZ28_07535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRZ28_07540	COG0121	glutamine amidotransferase
NRZ28_07570	COG2197	response regulator
NRZ28_07575	COG3850	Histidine kinase
NRZ28_07580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRZ28_07585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_07585	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_07595	COG0243	molybdopterin cofactor binding
NRZ28_07600	COG0437	4 iron, 4 sulfur cluster binding
NRZ28_07605	COG0348	domain, Protein
NRZ28_07615	COG3005	denitrification pathway
NRZ28_07620	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRZ28_07625	COG0315	cyclic pyranopterin monophosphate synthase activity
NRZ28_07630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NRZ28_07635	COG0314	molybdopterin synthase activity
NRZ28_07650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NRZ28_07655	COG2267	carboxylic ester hydrolase activity
NRZ28_07660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRZ28_07670	COG0302	gtp cyclohydrolase
NRZ28_07675	COG0840	transmembrane signaling receptor activity
NRZ28_07680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NRZ28_07690	COG0583	DNA-binding transcription factor activity
NRZ28_07720	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRZ28_07735	COG1166	arginine decarboxylase activity
NRZ28_07755	COG0814	amino acid
NRZ28_07765	COG3681	Belongs to the UPF0597 family
NRZ28_07770	COG2964	Protein conserved in bacteria
NRZ28_07780	COG1403	HNH endonuclease
NRZ28_07805	COG1187	pseudouridine synthase activity
NRZ28_07815	COG2807	transmembrane transport
NRZ28_07825	COG0583	DNA-binding transcription factor activity
NRZ28_07830	COG2271	Major facilitator Superfamily
NRZ28_07855	COG2979	Protein of unknown function (DUF533)
NRZ28_07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ28_07875	COG1294	oxidase, subunit
NRZ28_07885	COG2814	Major facilitator Superfamily
NRZ28_07890	COG0656	L-ascorbic acid biosynthetic process
NRZ28_07915	COG0583	DNA-binding transcription factor activity
NRZ28_07920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRZ28_07925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRZ28_07930	COG2271	Major facilitator Superfamily
NRZ28_07935	COG1349	DNA-binding transcription factor activity
NRZ28_07950	COG0584	glycerophosphoryl diester phosphodiesterase
NRZ28_07955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ28_07960	COG1605	Chorismate mutase
NRZ28_07960	COG0287	Prephenate dehydrogenase
NRZ28_07965	COG0583	DNA-binding transcription factor activity
NRZ28_07970	COG3085	chromosome segregation
NRZ28_07975	COG4574	serine-type endopeptidase inhibitor activity
NRZ28_07995	COG1770	oligopeptidase
NRZ28_08000	COG4771	TonB-dependent receptor
NRZ28_08005	COG3083	sulfuric ester hydrolase activity
NRZ28_08010	COG3082	Protein of unknown function (DUF1414)
NRZ28_08015	COG3081	Nucleoid-associated protein
NRZ28_08025	COG1175	transmembrane transport
NRZ28_08030	COG3833	ABC-type maltose transport systems, permease component
NRZ28_08035	COG3842	ATPase activity
NRZ28_08060	COG0425	Belongs to the sulfur carrier protein TusA family
NRZ28_08065	COG4783	chaperone-mediated protein folding
NRZ28_08075	COG1393	Belongs to the ArsC family
NRZ28_08090	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NRZ28_08100	COG2431	L-lysine efflux transmembrane transporter activity
NRZ28_08110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_08130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ28_08140	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ28_08145	COG2373	Large extracellular alpha-helical protein
NRZ28_08150	COG4953	penicillin-binding protein 1C
NRZ28_08160	COG0301	tRNA thio-modification
NRZ28_08160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ28_08175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRZ28_08220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRZ28_08240	COG0483	inositol monophosphate 1-phosphatase activity
NRZ28_08250	COG0625	glutathione transferase activity
NRZ28_08255	COG2814	Major facilitator Superfamily
NRZ28_08275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ28_08280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ28_08285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRZ28_08290	COG0509	glycine decarboxylation via glycine cleavage system
NRZ28_08295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRZ28_08295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRZ28_08300	COG0640	Transcriptional regulator
NRZ28_08305	COG0798	PFAM Bile acid sodium symporter
NRZ28_08310	COG1393	Belongs to the ArsC family
NRZ28_08325	COG3852	Histidine kinase
NRZ28_08335	COG3634	alkyl hydroperoxide reductase activity
NRZ28_08345	COG0517	IMP dehydrogenase activity
NRZ28_08350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NRZ28_08355	COG0343	queuine tRNA-ribosyltransferase activity
NRZ28_08360	COG1862	Preprotein translocase
NRZ28_08365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ28_08370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ28_08375	COG2897	thiosulfate sulfurtransferase activity
NRZ28_08385	COG0826	peptidase U32
NRZ28_08390	COG0826	peptidase U32
NRZ28_08395	COG3154	lipid carrier protein
NRZ28_08415	COG1104	cysteine desulfurase activity
NRZ28_08420	COG0822	iron-sulfur transferase activity
NRZ28_08430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRZ28_08435	COG0443	Heat shock 70 kDa protein
NRZ28_08440	COG0633	Ferredoxin
NRZ28_08450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ28_08455	COG0105	UTP biosynthetic process
NRZ28_08460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NRZ28_08480	COG0124	histidyl-tRNA synthetase
NRZ28_08485	COG2976	Protein conserved in bacteria
NRZ28_08490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ28_08495	COG1160	GTP binding
NRZ28_08500	COG1645	bacterial-type flagellum-dependent swarming motility
NRZ28_08505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRZ28_08510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRZ28_08510	COG0047	phosphoribosylformylglycinamidine synthase activity
NRZ28_08515	COG1007	ATP synthesis coupled electron transport
NRZ28_08520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_08530	COG0713	ATP synthesis coupled electron transport
NRZ28_08535	COG0839	Belongs to the complex I subunit 6 family
NRZ28_08540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_08545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRZ28_08550	COG1034	ATP synthesis coupled electron transport
NRZ28_08565	COG0649	NAD binding
NRZ28_08565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_08570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_08575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_08580	COG1360	Flagellar Motor Protein
NRZ28_08585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ28_08605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NRZ28_08625	COG0724	RNA recognition motif
NRZ28_08630	COG4989	oxidoreductase activity
NRZ28_08655	COG3437	response regulator, receiver
NRZ28_08660	COG0583	DNA-binding transcription factor activity
NRZ28_08670	COG3300	MHYT domain
NRZ28_08670	COG5001	Diguanylate cyclase
NRZ28_08675	COG0778	Nitroreductase
NRZ28_08695	COG0583	DNA-binding transcription factor activity
NRZ28_08705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRZ28_08710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRZ28_08715	COG0539	negative regulation of cytoplasmic translation
NRZ28_08720	COG0776	regulation of translation
NRZ28_08730	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NRZ28_08750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NRZ28_08755	COG0602	queuosine metabolic process
NRZ28_08760	COG3530	Putative quorum-sensing-regulated virulence factor
NRZ28_08765	COG2096	Adenosyltransferase
NRZ28_08770	COG2916	Histone family protein nucleoid-structuring protein H-NS
NRZ28_08775	COG1757	Na H antiporter
NRZ28_08780	COG1435	thymidine kinase activity
NRZ28_08815	COG3501	Rhs element vgr protein
NRZ28_08890	COG3829	transcription factor binding
NRZ28_08955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRZ28_08960	COG1278	Cold shock
NRZ28_08965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NRZ28_08970	COG0542	response to heat
NRZ28_08975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NRZ28_08980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NRZ28_08985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NRZ28_08990	COG3134	Outer membrane lipoprotein
NRZ28_08995	COG3706	GGDEF domain
NRZ28_09000	COG0492	ferredoxin-NADP+ reductase activity
NRZ28_09005	COG0686	Belongs to the AlaDH PNT family
NRZ28_09015	COG0531	amino acid
NRZ28_09015	COG1674	ftsk spoiiie
NRZ28_09020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NRZ28_09025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRZ28_09030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRZ28_09035	COG1286	toxin biosynthetic process
NRZ28_09040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NRZ28_09050	COG4172	Belongs to the ABC transporter superfamily
NRZ28_09060	COG4171	peptide transport system, permease
NRZ28_09065	COG4168	peptide transport system, permease
NRZ28_09075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRZ28_09080	COG1842	Phage shock protein A
NRZ28_09095	COG3106	COG3106 Predicted ATPase
NRZ28_09100	COG3768	UPF0283 membrane protein
NRZ28_09110	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRZ28_09130	COG2199	diguanylate cyclase activity
NRZ28_09135	COG2885	chlorophyll binding
NRZ28_09140	COG0861	Integral membrane protein TerC family
NRZ28_09155	COG1022	Amp-dependent synthetase and ligase
NRZ28_09160	COG0295	cytidine deaminase activity
NRZ28_09165	COG1346	cytolysis
NRZ28_09170	COG1380	Effector of murein hydrolase LrgA
NRZ28_09175	COG3345	alpha-galactosidase
NRZ28_09185	COG2925	Exonuclease
NRZ28_09190	COG2160	L-arabinose isomerase activity
NRZ28_09200	COG1069	ribulokinase activity
NRZ28_09205	COG1879	ABC-type sugar transport system periplasmic component
NRZ28_09215	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRZ28_09225	COG0583	DNA-binding transcription factor activity
NRZ28_09235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRZ28_09240	COG0254	rRNA binding
NRZ28_09255	COG1451	nucleotide metabolic process
NRZ28_09270	COG3069	C4-dicarboxylate transmembrane transporter activity
NRZ28_09280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ28_09280	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NRZ28_09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRZ28_09310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NRZ28_09315	COG1053	succinate dehydrogenase
NRZ28_09325	COG0567	Dehydrogenase, E1 component
NRZ28_09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRZ28_09335	COG0045	succinate-CoA ligase (ADP-forming) activity
NRZ28_09340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRZ28_09350	COG2983	Belongs to the UPF0260 family
NRZ28_09355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ28_09365	COG3842	ATPase activity
NRZ28_09370	COG1840	ABC-type Fe3 transport system, periplasmic component
NRZ28_09380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRZ28_09390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_09395	COG1882	Formate acetyltransferase
NRZ28_09400	COG2116	formate transmembrane transporter activity
NRZ28_09405	COG1944	ATP diphosphatase activity
NRZ28_09415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRZ28_09420	COG0612	Peptidase, M16
NRZ28_09425	COG0626	cystathionine gamma-synthase activity
NRZ28_09435	COG2910	NAD(P)H-binding
NRZ28_09440	COG0583	DNA-binding transcription factor activity
NRZ28_09450	COG4977	sequence-specific DNA binding
NRZ28_09455	COG4774	siderophore transport
NRZ28_09470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRZ28_09480	COG0516	GMP reductase activity
NRZ28_09480	COG0517	IMP dehydrogenase activity
NRZ28_09495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ28_09500	COG3046	protein related to deoxyribodipyrimidine photolyase
NRZ28_09510	COG3033	Beta-eliminating lyase
NRZ28_09515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRZ28_09525	COG1120	ATPase activity
NRZ28_09530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ28_09535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ28_09540	COG4771	TonB-dependent receptor
NRZ28_09580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRZ28_09585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NRZ28_09590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ28_09605	COG1570	exodeoxyribonuclease VII activity
NRZ28_09630	COG3158	transport of potassium into the cell
NRZ28_09635	COG0516	GMP reductase activity
NRZ28_09635	COG0517	IMP dehydrogenase activity
NRZ28_09640	COG0519	Catalyzes the synthesis of GMP from XMP
NRZ28_09640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRZ28_09680	COG2062	phosphohistidine phosphatase, SixA
NRZ28_09690	COG0697	spore germination
NRZ28_09695	COG4166	transmembrane transport
NRZ28_09700	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NRZ28_09705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRZ28_09715	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRZ28_09720	COG1136	(ABC) transporter
NRZ28_09725	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRZ28_09730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NRZ28_09740	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRZ28_09745	COG0740	serine-type endopeptidase activity
NRZ28_09750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRZ28_09755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRZ28_09760	COG0776	regulation of translation
NRZ28_09765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRZ28_09770	COG0488	(ABC) transporter
NRZ28_09775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRZ28_09780	COG3162	membrane
NRZ28_09795	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ28_09795	COG1024	Enoyl-CoA hydratase
NRZ28_09835	COG1115	amino acid carrier protein
NRZ28_09850	COG1584	GPR1 FUN34 yaaH family protein
NRZ28_09885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRZ28_09890	COG1960	acyl-CoA dehydrogenase activity
NRZ28_09900	COG1960	acyl-CoA dehydrogenase activity
NRZ28_09905	COG1024	Enoyl-CoA hydratase
NRZ28_09910	COG1024	Enoyl-CoA hydratase
NRZ28_09920	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_09930	COG0730	response to heat
NRZ28_09965	COG0583	DNA-binding transcription factor activity
NRZ28_09970	COG2723	6-phospho-beta-galactosidase activity
NRZ28_09975	COG5001	Diguanylate cyclase
NRZ28_09975	COG3300	MHYT domain
NRZ28_09985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ28_09995	COG0583	DNA-binding transcription factor activity
NRZ28_10010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRZ28_10015	COG0673	inositol 2-dehydrogenase activity
NRZ28_10020	COG0583	DNA-binding transcription factor activity
NRZ28_10030	COG1560	Kdo2-lipid A biosynthetic process
NRZ28_10035	COG1560	Kdo2-lipid A biosynthetic process
NRZ28_10060	COG0417	DNA replication proofreading
NRZ28_10090	COG0534	Mate efflux family protein
NRZ28_10100	COG0307	riboflavin synthase, alpha
NRZ28_10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_10115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NRZ28_10120	COG0697	spore germination
NRZ28_10125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRZ28_10170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRZ28_10175	COG3099	Belongs to the UPF0263 family
NRZ28_10180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NRZ28_10185	COG2894	cell division
NRZ28_10190	COG0850	regulation of cytokinetic process
NRZ28_10195	COG3100	YcgL domain-containing protein
NRZ28_10205	COG1760	l-serine dehydratase
NRZ28_10210	COG1760	l-serine dehydratase
NRZ28_10215	COG3123	guanosine phosphorylase activity
NRZ28_10235	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NRZ28_10240	COG2067	long-chain fatty acid transport protein
NRZ28_10255	COG1595	DNA-templated transcription, initiation
NRZ28_10285	COG0714	Associated with various cellular activities
NRZ28_10290	COG0183	Belongs to the thiolase family
NRZ28_10295	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ28_10295	COG1024	Enoyl-CoA hydratase
NRZ28_10315	COG3829	transcription factor binding
NRZ28_10320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRZ28_10325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRZ28_10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRZ28_10340	COG0549	Belongs to the carbamate kinase family
NRZ28_10345	COG0697	spore germination
NRZ28_10350	COG3608	succinylglutamate desuccinylase aspartoacylase
NRZ28_10350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NRZ28_10355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NRZ28_10360	COG2068	MobA-Related Protein
NRZ28_10365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_10365	COG0493	'glutamate synthase
NRZ28_10370	COG0402	S-adenosylhomocysteine deaminase activity
NRZ28_10375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRZ28_10380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRZ28_10380	COG2080	2 iron, 2 sulfur cluster binding
NRZ28_10385	COG2233	PERMEase
NRZ28_10390	COG0402	S-adenosylhomocysteine deaminase activity
NRZ28_10395	COG2252	PERMEase
NRZ28_10400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRZ28_10405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRZ28_10410	COG2080	2 iron, 2 sulfur cluster binding
NRZ28_10420	COG3134	Outer membrane lipoprotein
NRZ28_10430	COG1288	antiporter activity
NRZ28_10435	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ28_10440	COG2378	regulation of single-species biofilm formation
NRZ28_10450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRZ28_10450	COG0140	phosphoribosyl-ATP diphosphatase activity
NRZ28_10455	COG0107	imidazoleglycerol-phosphate synthase activity
NRZ28_10460	COG2205	protein histidine kinase activity
NRZ28_10460	COG0784	Response regulator, receiver
NRZ28_10460	COG2198	Histidine kinase
NRZ28_10465	COG2199	diguanylate cyclase activity
NRZ28_10470	COG3437	response regulator, receiver
NRZ28_10475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NRZ28_10480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NRZ28_10485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRZ28_10485	COG0131	Imidazoleglycerol-phosphate dehydratase
NRZ28_10490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRZ28_10495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRZ28_10500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NRZ28_10510	COG1199	ATP-dependent helicase activity
NRZ28_10515	COG1214	PFAM Peptidase M22, glycoprotease
NRZ28_10525	COG0596	Alpha beta hydrolase
NRZ28_10525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NRZ28_10525	COG2226	methyltransferase
NRZ28_10530	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ28_10550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRZ28_10555	COG2832	Protein of unknown function (DUF454)
NRZ28_10560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRZ28_10570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRZ28_10585	COG0517	IMP dehydrogenase activity
NRZ28_10585	COG0617	tRNA 3'-terminal CCA addition
NRZ28_10585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRZ28_10590	COG1643	Atp-dependent helicase
NRZ28_10600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRZ28_10610	COG3437	response regulator, receiver
NRZ28_10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRZ28_10620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NRZ28_10625	COG0709	Synthesizes selenophosphate from selenide and ATP
NRZ28_10640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRZ28_10650	COG1254	Belongs to the acylphosphatase family
NRZ28_10655	COG0625	glutathione transferase activity
NRZ28_10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ28_10660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ28_10665	COG0489	protein tyrosine kinase activity
NRZ28_10670	COG0572	uridine kinase
NRZ28_10675	COG0717	Belongs to the dCTP deaminase family
NRZ28_10680	COG0306	phosphate transporter
NRZ28_10685	COG1530	ribonuclease E activity
NRZ28_10690	COG0564	pseudouridine synthase activity
NRZ28_10700	COG0424	maF-like protein
NRZ28_10705	COG2814	Major facilitator Superfamily
NRZ28_10720	COG1399	metal-binding, possibly nucleic acid-binding protein
NRZ28_10725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRZ28_10730	COG0416	fatty acid biosynthetic process
NRZ28_10735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRZ28_10745	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_10750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ28_10760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRZ28_10765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRZ28_10770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRZ28_10775	COG0470	DNA polymerase III
NRZ28_10780	COG0084	hydrolase, TatD family'
NRZ28_10800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ28_10800	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NRZ28_10805	COG3008	intermembrane lipid transfer
NRZ28_10810	COG2995	paraquat-inducible protein a
NRZ28_10820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRZ28_10825	COG0372	Belongs to the citrate synthase family
NRZ28_10870	COG4221	oxidoreductase activity
NRZ28_10880	COG3141	response to X-ray
NRZ28_10900	COG4128	Pfam Zonular occludens toxin
NRZ28_10940	COG1067	ATP-dependent peptidase activity
NRZ28_10945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRZ28_10960	COG0488	(ABC) transporter
NRZ28_10970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRZ28_10970	COG0116	Belongs to the methyltransferase superfamily
NRZ28_10980	COG0167	dihydroorotate dehydrogenase activity
NRZ28_10985	COG2902	Dehydrogenase
NRZ28_10995	COG0308	aminopeptidase N
NRZ28_11005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NRZ28_11010	COG1956	GAF domain-containing protein
NRZ28_11020	COG3278	Belongs to the heme-copper respiratory oxidase family
NRZ28_11035	COG2010	Cytochrome c
NRZ28_11060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRZ28_11065	COG0589	response to stress
NRZ28_11070	COG0037	tRNA processing
NRZ28_11090	COG1869	D-ribose catabolic process
NRZ28_11095	COG1129	ABC transporter
NRZ28_11100	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRZ28_11105	COG1879	ABC-type sugar transport system periplasmic component
NRZ28_11110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ28_11115	COG1609	Transcriptional regulator
NRZ28_11120	COG3300	MHYT domain
NRZ28_11120	COG5001	Diguanylate cyclase
NRZ28_11150	COG0776	regulation of translation
NRZ28_11155	COG0072	phenylalanine-tRNA ligase activity
NRZ28_11155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ28_11160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRZ28_11165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRZ28_11170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRZ28_11175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRZ28_11180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRZ28_11205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRZ28_11215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ28_11220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ28_11225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ28_11230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NRZ28_11235	COG3313	Fe-S protein
NRZ28_11245	COG3716	PTS system mannose fructose sorbose family IID component
NRZ28_11250	COG3715	PTS system
NRZ28_11255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_11255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_11270	COG1609	Transcriptional regulator
NRZ28_11275	COG2140	Oxalate decarboxylase
NRZ28_11280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_11280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NRZ28_11280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_11285	COG1105	Belongs to the carbohydrate kinase PfkB family
NRZ28_11290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_11290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_11295	COG1609	Transcriptional regulator
NRZ28_11300	COG0814	amino acid
NRZ28_11310	COG5654	RES domain protein
NRZ28_11315	COG0513	Belongs to the DEAD box helicase family
NRZ28_11325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NRZ28_11330	COG2890	protein-(glutamine-N5) methyltransferase activity
NRZ28_11335	COG2840	Smr protein MutS2
NRZ28_11345	COG3706	GGDEF domain
NRZ28_11350	COG0588	phosphoglycerate mutase activity
NRZ28_11375	COG0740	serine-type endopeptidase activity
NRZ28_11385	COG2824	Alkylphosphonate utilization operon protein PhnA
NRZ28_11395	COG0384	phenazine biosynthesis protein PhzF
NRZ28_11425	COG0242	peptide deformylase activity
NRZ28_11445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRZ28_11450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NRZ28_11460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRZ28_11465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NRZ28_11475	COG0205	6-phosphofructokinase activity
NRZ28_11480	COG1473	amidohydrolase
NRZ28_11485	COG1011	Hydrolase
NRZ28_11490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ28_11520	COG3593	DNA synthesis involved in DNA repair
NRZ28_11540	COG0583	DNA-binding transcription factor activity
NRZ28_11545	COG0730	response to heat
NRZ28_11550	COG3148	PFAM DTW domain containing protein
NRZ28_11560	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRZ28_11570	COG0386	Belongs to the glutathione peroxidase family
NRZ28_11575	COG0513	Belongs to the DEAD box helicase family
NRZ28_11580	COG0456	acetyltransferase
NRZ28_11590	COG1742	UPF0060 membrane protein
NRZ28_11620	COG2329	Antibiotic biosynthesis monooxygenase
NRZ28_11625	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRZ28_11645	COG3243	poly(R)-hydroxyalkanoic acid synthase
NRZ28_11655	COG2501	S4 domain
NRZ28_11665	COG1132	(ABC) transporter
NRZ28_11670	COG1132	(ABC) transporter
NRZ28_11680	COG3118	belongs to the thioredoxin family
NRZ28_11685	COG0471	metal ion transport
NRZ28_11690	COG0058	SHG alpha-glucan phosphorylase activity
NRZ28_11720	COG0814	amino acid
NRZ28_11725	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NRZ28_11730	COG0514	ATP-dependent DNA helicase (RecQ)
NRZ28_11735	COG2766	serine protein kinase
NRZ28_11745	COG2719	SpoVR family
NRZ28_11750	COG2186	Transcriptional regulator
NRZ28_11755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ28_11760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRZ28_11765	COG0586	Pfam SNARE associated Golgi protein
NRZ28_11775	COG0556	nucleotide-excision repair
NRZ28_11785	COG0569	domain protein
NRZ28_11785	COG2985	domain, Protein
NRZ28_11790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRZ28_11815	COG3290	protein histidine kinase activity
NRZ28_11820	COG1846	Transcriptional regulator
NRZ28_11820	COG1940	carbohydrate kinase activity
NRZ28_11825	COG0840	transmembrane signaling receptor activity
NRZ28_11830	COG3012	SEC-C Motif Domain Protein
NRZ28_11835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRZ28_11840	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NRZ28_11845	COG0247	lactate metabolic process
NRZ28_11855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRZ28_11860	COG0437	4 iron, 4 sulfur cluster binding
NRZ28_11865	COG3301	Polysulphide reductase, NrfD
NRZ28_11870	COG1138	Cytochrome C-type biogenesis protein
NRZ28_11875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ28_11880	COG3088	subunit of a heme lyase
NRZ28_11880	COG4235	cytochrome complex assembly
NRZ28_11885	COG1051	belongs to the nudix hydrolase family
NRZ28_11895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ28_11905	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_11910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ28_11915	COG1535	isochorismatase
NRZ28_11915	COG3433	isochorismatase activity
NRZ28_11920	COG1021	2,3-dihydroxybenzoate-AMP ligase
NRZ28_11945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ28_11950	COG3300	MHYT domain
NRZ28_11950	COG5001	Diguanylate cyclase
NRZ28_11965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ28_11975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRZ28_11980	COG0563	adenylate kinase activity
NRZ28_11985	COG0326	Molecular chaperone. Has ATPase activity
NRZ28_11990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRZ28_12015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_12025	COG3158	transport of potassium into the cell
NRZ28_12035	COG2223	nitrite transmembrane transporter activity
NRZ28_12040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ28_12050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRZ28_12055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_12060	COG0651	ATP synthesis coupled electron transport
NRZ28_12065	COG0650	Formate hydrogenlyase subunit 4
NRZ28_12070	COG3261	NADH dehydrogenase
NRZ28_12070	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NRZ28_12075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ28_12080	COG3260	NADH ubiquinone oxidoreductase 20
NRZ28_12090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRZ28_12100	COG1921	L-seryl-tRNASec selenium transferase activity
NRZ28_12110	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NRZ28_12115	COG0298	carbon dioxide binding
NRZ28_12125	COG0309	Hydrogenase expression formation protein (HypE)
NRZ28_12130	COG0375	protein maturation
NRZ28_12140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NRZ28_12145	COG1124	(ABC) transporter
NRZ28_12150	COG0444	Belongs to the ABC transporter superfamily
NRZ28_12155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ28_12160	COG0601	transmembrane transport
NRZ28_12170	COG1773	rubredoxin
NRZ28_12175	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRZ28_12180	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NRZ28_12185	COG5557	Pfam Polysulphide reductase, NrfD
NRZ28_12190	COG0437	4 iron, 4 sulfur cluster binding
NRZ28_12195	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NRZ28_12200	COG0745	RESPONSE REGULATOR receiver
NRZ28_12210	COG0643	Histidine kinase
NRZ28_12210	COG2198	Histidine kinase
NRZ28_12215	COG0840	transmembrane signaling receptor activity
NRZ28_12215	COG3290	protein histidine kinase activity
NRZ28_12220	COG0835	chemotaxis
NRZ28_12230	COG2201	protein-glutamate methylesterase activity
NRZ28_12240	COG0840	transmembrane signaling receptor activity
NRZ28_12245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ28_12260	COG0659	secondary active sulfate transmembrane transporter activity
NRZ28_12290	COG0672	)-iron permease
NRZ28_12310	COG2814	Major facilitator Superfamily
NRZ28_12320	COG1136	(ABC) transporter
NRZ28_12325	COG0577	efflux transmembrane transporter activity
NRZ28_12355	COG1139	Iron-sulfur cluster binding protein
NRZ28_12360	COG0247	lactate metabolic process
NRZ28_12365	COG1620	l-lactate permease
NRZ28_12370	COG0583	DNA-binding transcription factor activity
NRZ28_12380	COG0346	lactoylglutathione lyase activity
NRZ28_12385	COG0596	Alpha beta hydrolase
NRZ28_12405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRZ28_12410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRZ28_12410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRZ28_12415	COG0527	aspartate kinase activity
NRZ28_12425	COG1368	sulfuric ester hydrolase activity
NRZ28_12430	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRZ28_12435	COG4667	esterase of the alpha-beta hydrolase superfamily
NRZ28_12445	COG0393	Putative heavy-metal-binding
NRZ28_12465	COG1252	NADH dehydrogenase
NRZ28_12470	COG3150	esterase
NRZ28_12475	COG2233	PERMEase
NRZ28_12490	COG2354	Protein conserved in bacteria
NRZ28_12500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ28_12505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ28_12540	COG0537	adenosine 5'-monophosphoramidase activity
NRZ28_12555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRZ28_12570	COG1301	dicarboxylic acid transport
NRZ28_12580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ28_12585	COG0861	Integral membrane protein TerC family
NRZ28_12605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ28_12610	COG0601	transmembrane transport
NRZ28_12620	COG2095	MarC family integral membrane protein
NRZ28_12630	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_12630	COG1454	alcohol dehydrogenase
NRZ28_12635	COG2199	diguanylate cyclase activity
NRZ28_12635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ28_12640	COG3275	phosphorelay sensor kinase activity
NRZ28_12645	COG3279	Response regulator of the LytR AlgR family
NRZ28_12650	COG1966	Carbon starvation protein
NRZ28_12660	COG1566	PFAM secretion protein HlyD family protein
NRZ28_12665	COG1061	Type III restriction enzyme res subunit
NRZ28_12670	COG2027	D-alanyl-D-alanine carboxypeptidase
NRZ28_12675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NRZ28_12685	COG0436	Aminotransferase
NRZ28_12690	COG1288	antiporter activity
NRZ28_12695	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRZ28_12715	COG0697	spore germination
NRZ28_12720	COG4657	Part of a membrane complex involved in electron transport
NRZ28_12725	COG2878	Part of a membrane complex involved in electron transport
NRZ28_12735	COG4658	electron transport chain
NRZ28_12740	COG4659	FMN binding
NRZ28_12745	COG4660	Part of a membrane complex involved in electron transport
NRZ28_12750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRZ28_12755	COG0346	lactoylglutathione lyase activity
NRZ28_12770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRZ28_12775	COG2056	Na+-H+ antiporter family
NRZ28_12785	COG2050	protein possibly involved in aromatic compounds catabolism
NRZ28_12795	COG0247	lactate metabolic process
NRZ28_12795	COG0277	FAD linked oxidase domain protein
NRZ28_12805	COG1253	flavin adenine dinucleotide binding
NRZ28_12810	COG1902	pentaerythritol trinitrate reductase activity
NRZ28_12820	COG0647	UMP catabolic process
NRZ28_12825	COG4651	solute:proton antiporter activity
NRZ28_12825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRZ28_12835	COG0367	asparagine synthase
NRZ28_12845	COG0625	glutathione transferase activity
NRZ28_12855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NRZ28_12870	COG0564	pseudouridine synthase activity
NRZ28_12875	COG5001	Diguanylate cyclase
NRZ28_12880	COG0840	transmembrane signaling receptor activity
NRZ28_12890	COG0392	lysyltransferase activity
NRZ28_12890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRZ28_12895	COG2194	sulfuric ester hydrolase activity
NRZ28_12910	COG0670	Belongs to the BI1 family
NRZ28_12915	COG1289	transmembrane transporter activity
NRZ28_12920	COG2920	part of a sulfur-relay system
NRZ28_12925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NRZ28_12930	COG0285	dihydrofolate synthase activity
NRZ28_12935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRZ28_12940	COG0101	tRNA pseudouridine synthase activity
NRZ28_12950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRZ28_12955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRZ28_12960	COG0671	phosphoesterase, PA-phosphatase related
NRZ28_12965	COG1464	Belongs to the NlpA lipoprotein family
NRZ28_12995	COG0574	Belongs to the PEP-utilizing enzyme family
NRZ28_12995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRZ28_13000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRZ28_13085	COG1242	4 iron, 4 sulfur cluster binding
NRZ28_13090	COG0067	glutamate synthase
NRZ28_13090	COG0070	glutamate synthase
NRZ28_13090	COG0069	glutamate synthase activity
NRZ28_13095	COG0493	'glutamate synthase
NRZ28_13100	COG1126	abc transporter atp-binding protein
NRZ28_13105	COG0765	amino acid transport
NRZ28_13110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_13125	COG0789	Transcriptional regulator
NRZ28_13140	COG4104	PAAR repeat-containing protein
NRZ28_13150	COG0513	Belongs to the DEAD box helicase family
NRZ28_13155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ28_13190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRZ28_13195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRZ28_13200	COG0505	Belongs to the CarA family
NRZ28_13205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NRZ28_13215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRZ28_13220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NRZ28_13225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRZ28_13230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRZ28_13235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ28_13240	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NRZ28_13245	COG4139	cobalamin transport
NRZ28_13250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_13250	COG2205	protein histidine kinase activity
NRZ28_13265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ28_13290	COG0023	Translation Initiation Factor
NRZ28_13295	COG2119	membrane
NRZ28_13325	COG2203	Gaf domain
NRZ28_13325	COG2199	diguanylate cyclase activity
NRZ28_13350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRZ28_13360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ28_13365	COG3301	Polysulphide reductase, NrfD
NRZ28_13370	COG0437	4 iron, 4 sulfur cluster binding
NRZ28_13375	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRZ28_13430	COG0322	excinuclease ABC activity
NRZ28_13435	COG2197	response regulator
NRZ28_13440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NRZ28_13445	COG2835	tetraacyldisaccharide 4'-kinase activity
NRZ28_13450	COG1663	tetraacyldisaccharide 4'-kinase activity
NRZ28_13455	COG1132	(ABC) transporter
NRZ28_13460	COG0658	competence protein
NRZ28_13460	COG2333	competence protein COMEC
NRZ28_13475	COG0433	COG0433 Predicted ATPase
NRZ28_13480	COG1448	Aminotransferase
NRZ28_13495	COG1199	ATP-dependent helicase activity
NRZ28_13505	COG0123	including yeast histone deacetylase and acetoin utilization protein
NRZ28_13510	COG0477	Major facilitator Superfamily
NRZ28_13515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRZ28_13540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRZ28_13555	COG2271	Major facilitator Superfamily
NRZ28_13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_13570	COG0765	amino acid transport
NRZ28_13575	COG1126	abc transporter atp-binding protein
NRZ28_13595	COG0531	amino acid
NRZ28_13610	COG1253	flavin adenine dinucleotide binding
NRZ28_13615	COG0704	Plays a role in the regulation of phosphate uptake
NRZ28_13620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRZ28_13625	COG0581	inorganic phosphate transmembrane transporter activity
NRZ28_13630	COG0573	inorganic phosphate transmembrane transporter activity
NRZ28_13635	COG0590	tRNA wobble adenosine to inosine editing
NRZ28_13650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NRZ28_13670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRZ28_13675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRZ28_13680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRZ28_13685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRZ28_13710	COG2716	regulation of RNA biosynthetic process
NRZ28_13715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRZ28_13725	COG2239	Acts as a magnesium transporter
NRZ28_13735	COG1256	bacterial-type flagellum assembly
NRZ28_13740	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRZ28_13740	COG3951	Flagellar rod assembly protein muramidase FlgJ
NRZ28_13745	COG1706	bacterial-type flagellum-dependent cell motility
NRZ28_13750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRZ28_13760	COG4787	bacterial-type flagellum-dependent cell motility
NRZ28_13780	COG1815	bacterial-type flagellum-dependent cell motility
NRZ28_13785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NRZ28_13790	COG0835	chemotaxis
NRZ28_13790	COG0784	Response regulator, receiver
NRZ28_13795	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NRZ28_13810	COG0622	Phosphoesterase
NRZ28_13840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRZ28_13845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ28_13850	COG1882	Formate acetyltransferase
NRZ28_13855	COG1349	DNA-binding transcription factor activity
NRZ28_13860	COG0697	spore germination
NRZ28_13890	COG1278	Cold shock
NRZ28_13930	COG3132	Protein of unknown function, DUF480
NRZ28_13940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ28_13960	COG3206	protein involved in exopolysaccharide biosynthesis
NRZ28_13960	COG0489	protein tyrosine kinase activity
NRZ28_13965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRZ28_13990	COG1216	Glycosyl transferase, family 2
NRZ28_14030	COG2194	sulfuric ester hydrolase activity
NRZ28_14035	COG0217	transcriptional regulatory protein
NRZ28_14040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRZ28_14045	COG1801	Protein of unknown function DUF72
NRZ28_14050	COG4106	trans-aconitate 2-methyltransferase activity
NRZ28_14055	COG0500	methyltransferase
NRZ28_14075	COG0450	alkyl hydroperoxide reductase
NRZ28_14080	COG0583	DNA-binding transcription factor activity
NRZ28_14090	COG0791	NLP P60 protein
NRZ28_14105	COG1309	transcriptional regulator
NRZ28_14145	COG0534	Mate efflux family protein
NRZ28_14170	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRZ28_14170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRZ28_14170	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRZ28_14170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NRZ28_14180	COG0633	Ferredoxin
NRZ28_14180	COG3217	Mosc domain protein beta barrel domain protein
NRZ28_14180	COG0633	Ferredoxin
NRZ28_14180	COG3217	Mosc domain protein beta barrel domain protein
NRZ28_14190	COG0501	Belongs to the peptidase M48B family
NRZ28_14195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NRZ28_14200	COG1073	alpha beta
NRZ28_14200	COG2226	methyltransferase
NRZ28_14205	COG0156	8-amino-7-oxononanoate synthase activity
NRZ28_14210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRZ28_14230	COG0017	Asparaginyl-tRNA synthetase
NRZ28_14235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRZ28_14245	COG1473	amidohydrolase
NRZ28_14250	COG3069	C4-dicarboxylate transmembrane transporter activity
NRZ28_14260	COG0583	DNA-binding transcription factor activity
NRZ28_14265	COG1393	Belongs to the ArsC family
NRZ28_14270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRZ28_14275	COG1876	peptidase activity
NRZ28_14285	COG3263	regulation of cellular component size
NRZ28_14305	COG1280	lysine exporter protein (LysE YggA)
NRZ28_14335	COG0564	pseudouridine synthase activity
NRZ28_14345	COG1454	alcohol dehydrogenase
NRZ28_14395	COG4964	Belongs to the GSP D family
NRZ28_14425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ28_14430	COG0702	epimerase
NRZ28_14435	COG2914	Belongs to the UPF0125 (RnfH) family
NRZ28_14440	COG2867	negative regulation of translational initiation
NRZ28_14445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRZ28_14465	COG0732	type I restriction modification DNA specificity domain
NRZ28_14495	COG0583	DNA-binding transcription factor activity
NRZ28_14500	COG2610	gluconate transmembrane transporter activity
NRZ28_14505	COG3048	D-serine ammonia-lyase activity
NRZ28_14515	COG0538	isocitrate dehydrogenase activity
NRZ28_14520	COG2207	Transcriptional regulator
NRZ28_14540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_14555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRZ28_14560	COG1263	PTS System
NRZ28_14560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_14565	COG1609	Transcriptional regulator
NRZ28_14595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_14595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_14595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_14600	COG5599	Phosphatase
NRZ28_14615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_14615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_14615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ28_14625	COG1187	pseudouridine synthase activity
NRZ28_14635	COG0482	sulfurtransferase activity
NRZ28_14640	COG2915	High frequency lysogenization protein hflD homolog
NRZ28_14645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRZ28_14650	COG2850	peptidyl-arginine hydroxylation
NRZ28_14655	COG3153	acetyltransferase
NRZ28_14665	COG0625	glutathione transferase activity
NRZ28_14670	COG0259	pyridoxamine-phosphate oxidase activity
NRZ28_14685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ28_14685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ28_14690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NRZ28_14705	COG3088	subunit of a heme lyase
NRZ28_14705	COG4235	cytochrome complex assembly
NRZ28_14710	COG4235	cytochrome complex assembly
NRZ28_14710	COG3088	subunit of a heme lyase
NRZ28_14715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ28_14720	COG1138	Cytochrome C-type biogenesis protein
NRZ28_14725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NRZ28_14730	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ28_14735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ28_14740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ28_14755	COG0835	chemotaxis
NRZ28_14765	COG1192	Involved in chromosome partitioning
NRZ28_14770	COG1360	Flagellar Motor Protein
NRZ28_14775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ28_14780	COG2201	protein-glutamate methylesterase activity
NRZ28_14785	COG2198	Histidine kinase
NRZ28_14785	COG0784	Response regulator, receiver
NRZ28_14785	COG0643	Histidine kinase
NRZ28_14790	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NRZ28_14815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRZ28_14825	COG1684	flagellar biosynthetic protein fliR
NRZ28_14880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRZ28_14890	COG1677	Flagellar hook-basal body complex protein FliE
NRZ28_14905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRZ28_14915	COG1073	alpha beta
NRZ28_14915	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NRZ28_14915	COG3064	Membrane
NRZ28_14920	COG2994	toxin metabolic process
NRZ28_14930	COG2274	protein secretion by the type I secretion system
NRZ28_14940	COG2274	protein secretion by the type I secretion system
NRZ28_14960	COG1737	Transcriptional regulator
NRZ28_14965	COG0469	pyruvate kinase activity
NRZ28_14980	COG1960	acyl-CoA dehydrogenase activity
NRZ28_14990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRZ28_15000	COG0243	molybdopterin cofactor binding
NRZ28_15005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRZ28_15010	COG0583	DNA-binding transcription factor activity
NRZ28_15045	COG1454	alcohol dehydrogenase
NRZ28_15045	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_15055	COG1454	alcohol dehydrogenase
NRZ28_15055	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_15060	COG1882	Formate acetyltransferase
NRZ28_15065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ28_15075	COG4869	propanediol catabolic process
NRZ28_15095	COG5002	protein histidine kinase activity
NRZ28_15100	COG0745	RESPONSE REGULATOR receiver
NRZ28_15105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_15110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ28_15120	COG1376	ErfK ybiS ycfS ynhG family protein
NRZ28_15120	COG1388	LysM domain
NRZ28_15135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NRZ28_15140	COG0791	NLP P60 protein
NRZ28_15150	COG3118	belongs to the thioredoxin family
NRZ28_15160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRZ28_15165	COG0788	formyltetrahydrofolate deformylase activity
NRZ28_15175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ28_15195	COG0366	Alpha amylase catalytic
NRZ28_15200	COG0739	heme binding
NRZ28_15200	COG0741	lytic transglycosylase activity
NRZ28_15200	COG1196	nuclear chromosome segregation
NRZ28_15205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRZ28_15210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRZ28_15215	COG0673	inositol 2-dehydrogenase activity
NRZ28_15235	COG3152	Membrane
NRZ28_15275	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_15280	COG1280	lysine exporter protein (LysE YggA)
NRZ28_15290	COG1032	radical SAM domain protein
NRZ28_15300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ28_15305	COG1566	PFAM secretion protein HlyD family protein
NRZ28_15315	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRZ28_15320	COG0733	neurotransmitter:sodium symporter activity
NRZ28_15350	COG0281	malic enzyme
NRZ28_15360	COG0534	Mate efflux family protein
NRZ28_15375	COG2233	PERMEase
NRZ28_15380	COG0095	Lipoate-protein ligase
NRZ28_15385	COG1115	amino acid carrier protein
NRZ28_15390	COG0019	diaminopimelate decarboxylase activity
NRZ28_15400	COG0678	peroxiredoxin activity
NRZ28_15410	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRZ28_15430	COG1131	(ABC) transporter
NRZ28_15435	COG0545	Peptidyl-prolyl cis-trans isomerase
NRZ28_15465	COG5002	protein histidine kinase activity
NRZ28_15470	COG0745	RESPONSE REGULATOR receiver
NRZ28_15475	COG0346	lactoylglutathione lyase activity
NRZ28_15480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRZ28_15485	COG1960	acyl-CoA dehydrogenase activity
NRZ28_15490	COG3284	Transcriptional regulator
NRZ28_15505	COG0697	spore germination
NRZ28_15510	COG4565	transcriptional regulatory protein
NRZ28_15515	COG3290	protein histidine kinase activity
NRZ28_15520	COG0281	malic enzyme
NRZ28_15535	COG1846	Transcriptional regulator
NRZ28_15540	COG1566	PFAM secretion protein HlyD family protein
NRZ28_15570	COG0602	queuosine metabolic process
NRZ28_15575	COG1328	CTP reductase activity
NRZ28_15585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRZ28_15590	COG3115	cell septum assembly
NRZ28_15595	COG1196	nuclear chromosome segregation
NRZ28_15605	COG2860	membrane
NRZ28_15615	COG3108	Peptidase M15
NRZ28_15620	COG2989	Protein conserved in bacteria
NRZ28_15635	COG0463	Glycosyl transferase, family 2
NRZ28_15650	COG0366	Alpha amylase catalytic
NRZ28_15690	COG3706	GGDEF domain
NRZ28_15700	COG3590	peptidase
NRZ28_15710	COG0488	(ABC) transporter
NRZ28_15720	COG0531	amino acid
NRZ28_15725	COG0814	amino acid
NRZ28_15740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRZ28_15745	COG1982	Orn Lys Arg decarboxylase major
NRZ28_15750	COG0531	amino acid
NRZ28_15755	COG3710	Transcriptional regulator
NRZ28_15760	COG0825	malonyl-CoA metabolic process
NRZ28_15770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRZ28_15775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ28_15780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ28_15785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRZ28_15790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ28_15805	COG0750	zinc metalloprotease
NRZ28_15810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NRZ28_15815	COG0575	Belongs to the CDS family
NRZ28_15820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRZ28_15825	COG0233	cytoplasmic translational termination
NRZ28_15830	COG0528	UMP kinase activity
NRZ28_15835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRZ28_15840	COG0052	Belongs to the universal ribosomal protein uS2 family
NRZ28_15845	COG0024	Methionine aminopeptidase
NRZ28_15850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NRZ28_15855	COG2171	N-acyltransferase activity
NRZ28_15865	COG1263	PTS System
NRZ28_15865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_15875	COG4580	involved in the transport of maltose and maltodextrins
NRZ28_15885	COG0564	pseudouridine synthase activity
NRZ28_15890	COG3098	single-species biofilm formation
NRZ28_15915	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NRZ28_15925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRZ28_15925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRZ28_15940	COG1611	Belongs to the LOG family
NRZ28_15945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ28_15950	COG0473	3-isopropylmalate dehydrogenase activity
NRZ28_15960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NRZ28_15965	COG2363	Small membrane protein
NRZ28_15975	COG0583	DNA-binding transcription factor activity
NRZ28_15980	COG0840	transmembrane signaling receptor activity
NRZ28_15985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRZ28_16000	COG1477	protein flavinylation
NRZ28_16005	COG2871	sodium ion transport
NRZ28_16010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ28_16015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ28_16020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ28_16025	COG1805	sodium ion transport
NRZ28_16030	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ28_16035	COG0271	Belongs to the BolA IbaG family
NRZ28_16040	COG2813	Specifically methylates the guanine in position
NRZ28_16050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRZ28_16060	COG2211	Major facilitator Superfamily
NRZ28_16065	COG3248	Nucleoside-binding outer membrane protein
NRZ28_16070	COG1666	GTP binding
NRZ28_16075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRZ28_16080	COG0693	protein deglycase activity
NRZ28_16145	COG2771	luxR family
NRZ28_16155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ28_16155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ28_16160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRZ28_16170	COG1151	hydroxylamine reductase activity
NRZ28_16175	COG0783	Belongs to the Dps family
NRZ28_16200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRZ28_16215	COG4221	oxidoreductase activity
NRZ28_16225	COG0415	Belongs to the DNA photolyase family
NRZ28_16230	COG0789	Transcriptional regulator
NRZ28_16235	COG3272	Protein of unknown function (DUF1722)
NRZ28_16265	COG0077	Prephenate dehydratase
NRZ28_16265	COG1605	Chorismate mutase
NRZ28_16295	COG5377	YqaJ viral recombinase family
NRZ28_16340	COG2003	Belongs to the UPF0758 family
NRZ28_16380	COG1715	Restriction endonuclease
NRZ28_16405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRZ28_16435	COG1349	DNA-binding transcription factor activity
NRZ28_16440	COG2084	Dehydrogenase
NRZ28_16450	COG0235	Class ii aldolase
NRZ28_16455	COG3622	Belongs to the hyi family
NRZ28_16460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ28_16465	COG2610	gluconate transmembrane transporter activity
NRZ28_16475	COG0840	transmembrane signaling receptor activity
NRZ28_16485	COG0300	oxidoreductase activity
NRZ28_16510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NRZ28_16525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRZ28_16530	COG0826	peptidase U32
NRZ28_16535	COG1280	lysine exporter protein (LysE YggA)
NRZ28_16545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRZ28_16550	COG0840	transmembrane signaling receptor activity
NRZ28_16565	COG0643	Histidine kinase
NRZ28_16565	COG2198	Histidine kinase
NRZ28_16575	COG0835	chemotaxis
NRZ28_16580	COG0840	transmembrane signaling receptor activity
NRZ28_16590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NRZ28_16595	COG2201	protein-glutamate methylesterase activity
NRZ28_16600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRZ28_16625	COG2205	protein histidine kinase activity
NRZ28_16625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_16630	COG2197	response regulator
NRZ28_16640	COG3188	usher protein
NRZ28_16655	COG2203	Gaf domain
NRZ28_16655	COG2199	diguanylate cyclase activity
NRZ28_16655	COG2200	EAL domain
NRZ28_16660	COG0826	peptidase U32
NRZ28_16665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ28_16675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ28_16690	COG2200	EAL domain
NRZ28_16695	COG0737	Belongs to the 5'-nucleotidase family
NRZ28_16715	COG2204	response regulator
NRZ28_16720	COG0545	Peptidyl-prolyl cis-trans isomerase
NRZ28_16735	COG1047	Peptidyl-prolyl cis-trans
NRZ28_16740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NRZ28_16750	COG0784	Response regulator, receiver
NRZ28_16750	COG0835	chemotaxis
NRZ28_16755	COG0429	hydrolase of the alpha beta-hydrolase fold
NRZ28_16760	COG5001	Diguanylate cyclase
NRZ28_16760	COG4251	negative regulation of phosphorylation
NRZ28_16760	COG3706	GGDEF domain
NRZ28_16760	COG2203	Gaf domain
NRZ28_16765	COG3089	Belongs to the UPF0270 family
NRZ28_16775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ28_16780	COG0463	Glycosyl transferase, family 2
NRZ28_16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ28_16785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRZ28_16790	COG0726	polysaccharide deacetylase
NRZ28_16795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NRZ28_16800	COG2076	Multidrug Resistance protein
NRZ28_16805	COG2076	Multidrug Resistance protein
NRZ28_16810	COG3954	Phosphoribulokinase
NRZ28_16825	COG1765	OsmC-like protein
NRZ28_16835	COG2226	methyltransferase
NRZ28_16840	COG3397	chitin binding
NRZ28_16855	COG2205	protein histidine kinase activity
NRZ28_16855	COG2202	Pas domain
NRZ28_16865	COG3655	Transcriptional regulator
NRZ28_16870	COG2814	Major facilitator Superfamily
NRZ28_16875	COG4771	TonB-dependent receptor
NRZ28_16895	COG0748	coenzyme F420 binding
NRZ28_16900	COG3721	Heme iron utilization protein
NRZ28_16910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ28_16935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRZ28_16940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ28_16945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NRZ28_16965	COG0741	lytic transglycosylase activity
NRZ28_16970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRZ28_16985	COG0488	(ABC) transporter
NRZ28_16995	COG2252	PERMEase
NRZ28_17000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRZ28_17005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRZ28_17010	COG3178	'Phosphotransferase
NRZ28_17015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NRZ28_17025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NRZ28_17030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRZ28_17035	COG2967	ApaG domain
NRZ28_17040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRZ28_17050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRZ28_17055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ28_17070	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ28_17075	COG3314	Sporulation integral membrane protein YlbJ
NRZ28_17080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NRZ28_17085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRZ28_17090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NRZ28_17095	COG0142	geranyltranstransferase activity
NRZ28_17100	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NRZ28_17105	COG0330	HflC and HflK could
NRZ28_17110	COG0330	HflC and HflK could
NRZ28_17115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRZ28_17120	COG1923	regulation of RNA biosynthetic process
NRZ28_17125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NRZ28_17130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NRZ28_17140	COG0802	atpase or kinase
NRZ28_17145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NRZ28_17145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRZ28_17150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NRZ28_17165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRZ28_17170	COG2011	ABC-type metal ion transport system permease component
NRZ28_17175	COG1464	Belongs to the NlpA lipoprotein family
NRZ28_17195	COG0840	transmembrane signaling receptor activity
NRZ28_17220	COG0784	Response regulator, receiver
NRZ28_17220	COG2198	Histidine kinase
NRZ28_17220	COG5002	protein histidine kinase activity
NRZ28_17240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NRZ28_17255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRZ28_17260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NRZ28_17270	COG2716	regulation of RNA biosynthetic process
NRZ28_17275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NRZ28_17280	COG3013	Belongs to the UPF0304 family
NRZ28_17290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRZ28_17295	COG0280	phosphate acetyltransferase
NRZ28_17295	COG0857	belongs to the CobB CobQ family
NRZ28_17305	COG0028	Belongs to the TPP enzyme family
NRZ28_17315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRZ28_17320	COG0671	phosphoesterase, PA-phosphatase related
NRZ28_17330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRZ28_17335	COG0473	3-isopropylmalate dehydrogenase activity
NRZ28_17340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NRZ28_17345	COG0066	3-isopropylmalate dehydratase activity
NRZ28_17360	COG4143	(ABC) transporter
NRZ28_17370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NRZ28_17375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRZ28_17385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ28_17415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRZ28_17420	COG0564	pseudouridine synthase activity
NRZ28_17430	COG5001	Diguanylate cyclase
NRZ28_17430	COG3300	MHYT domain
NRZ28_17440	COG0459	protein refolding
NRZ28_17445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRZ28_17450	COG0534	Mate efflux family protein
NRZ28_17455	COG3030	protein affecting phage T7 exclusion by the F plasmid
NRZ28_17460	COG1027	Aspartate ammonia-lyase
NRZ28_17465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRZ28_17475	COG0477	Major facilitator Superfamily
NRZ28_17490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ28_17495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ28_17505	COG0673	inositol 2-dehydrogenase activity
NRZ28_17515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRZ28_17520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRZ28_17525	COG3036	rescue of stalled ribosome
NRZ28_17530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRZ28_17540	COG0138	bifunctional purine biosynthesis protein purh
NRZ28_17545	COG0151	Belongs to the GarS family
NRZ28_17570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRZ28_17575	COG0358	DNA primase activity
NRZ28_17580	COG1610	YqeY-like protein
NRZ28_17585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NRZ28_17590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRZ28_17605	COG1238	metal cluster binding
NRZ28_17610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRZ28_17615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NRZ28_17620	COG0585	pseudouridine synthase activity
NRZ28_17630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NRZ28_17635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NRZ28_17640	COG0148	phosphopyruvate hydratase activity
NRZ28_17645	COG0504	CTP synthase activity
NRZ28_17650	COG3956	TIGRFAM MazG family protein
NRZ28_17655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRZ28_17660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ28_17670	COG4807	Protein conserved in bacteria
NRZ28_17675	COG3023	N-Acetylmuramoyl-L-alanine amidase
NRZ28_17680	COG1349	DNA-binding transcription factor activity
NRZ28_17690	COG2222	sugar isomerase
NRZ28_17695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_17705	COG3716	PTS system mannose fructose sorbose family IID component
NRZ28_17710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_17715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRZ28_17730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NRZ28_17735	COG1381	Involved in DNA repair and RecF pathway recombination
NRZ28_17745	COG0571	ribonuclease III activity
NRZ28_17750	COG0681	Belongs to the peptidase S26 family
NRZ28_17755	COG0481	GTPase activity
NRZ28_17770	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NRZ28_17775	COG1595	DNA-templated transcription, initiation
NRZ28_17780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRZ28_17790	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NRZ28_17795	COG0354	folic acid binding
NRZ28_17820	COG4232	protein-disulfide reductase activity
NRZ28_17835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ28_17845	COG0126	phosphoglycerate kinase activity
NRZ28_17850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRZ28_17855	COG1940	carbohydrate kinase activity
NRZ28_17860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NRZ28_17875	COG4991	sh3 domain protein
NRZ28_17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRZ28_17895	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NRZ28_17900	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ28_17920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRZ28_17925	COG0765	amino acid transport
NRZ28_17930	COG0765	amino acid transport
NRZ28_17935	COG1126	abc transporter atp-binding protein
NRZ28_17940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ28_17955	COG0745	RESPONSE REGULATOR receiver
NRZ28_17960	COG2205	protein histidine kinase activity
NRZ28_17965	COG2816	NAD+ diphosphatase activity
NRZ28_17995	COG2070	2-Nitropropane dioxygenase
NRZ28_18020	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
NRZ28_18040	COG3706	GGDEF domain
NRZ28_18045	COG0513	Belongs to the DEAD box helicase family
NRZ28_18065	COG0154	amidase activity
NRZ28_18070	COG2957	Belongs to the agmatine deiminase family
NRZ28_18080	COG2852	Protein conserved in bacteria
NRZ28_18090	COG1902	pentaerythritol trinitrate reductase activity
NRZ28_18125	COG5001	Diguanylate cyclase
NRZ28_18125	COG3300	MHYT domain
NRZ28_18135	COG0714	Associated with various cellular activities
NRZ28_18145	COG0456	acetyltransferase
NRZ28_18155	COG1022	Amp-dependent synthetase and ligase
NRZ28_18165	COG2918	glutathione biosynthetic process
NRZ28_18170	COG0612	Peptidase, M16
NRZ28_18175	COG1238	metal cluster binding
NRZ28_18200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ28_18205	COG0359	binds to the 23S rRNA
NRZ28_18210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRZ28_18215	COG0360	Binds together with S18 to 16S ribosomal RNA
NRZ28_18220	COG1914	H( )-stimulated, divalent metal cation uptake system
NRZ28_18240	COG2153	protein acetylation
NRZ28_18250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRZ28_18270	COG0557	exoribonuclease II activity
NRZ28_18275	COG3706	GGDEF domain
NRZ28_18280	COG1854	S-ribosylhomocysteine lyase activity
NRZ28_18295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRZ28_18295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRZ28_18335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NRZ28_18340	COG1047	Peptidyl-prolyl cis-trans
NRZ28_18345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NRZ28_18350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRZ28_18355	COG0196	riboflavin kinase activity
NRZ28_18360	COG0728	peptidoglycan biosynthetic process
NRZ28_18365	COG0268	Binds directly to 16S ribosomal RNA
NRZ28_18370	COG0640	Transcriptional regulator
NRZ28_18375	COG0583	DNA-binding transcription factor activity
NRZ28_18385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ28_18390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NRZ28_18395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NRZ28_18400	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NRZ28_18405	COG1051	belongs to the nudix hydrolase family
NRZ28_18410	COG3066	DNA modification
NRZ28_18420	COG0335	large ribosomal subunit rRNA binding
NRZ28_18425	COG0336	Belongs to the RNA methyltransferase TrmD family
NRZ28_18430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRZ28_18435	COG0228	four-way junction DNA binding
NRZ28_18440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRZ28_18445	COG4137	Cytochrome C assembly protein
NRZ28_18450	COG4536	flavin adenine dinucleotide binding
NRZ28_18460	COG1017	nitric oxide dioxygenase activity
NRZ28_18460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ28_18465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NRZ28_18470	COG0039	L-malate dehydrogenase activity
NRZ28_18475	COG4160	amino acid transport
NRZ28_18480	COG4215	(ABC) transporter
NRZ28_18485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_18490	COG1126	abc transporter atp-binding protein
NRZ28_18495	COG1438	arginine binding
NRZ28_18500	COG2837	iron assimilation
NRZ28_18505	COG3842	ATPase activity
NRZ28_18515	COG1840	ABC-type Fe3 transport system, periplasmic component
NRZ28_18520	COG0347	Belongs to the P(II) protein family
NRZ28_18535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ28_18540	COG0583	DNA-binding transcription factor activity
NRZ28_18555	COG1929	Belongs to the glycerate kinase type-1 family
NRZ28_18560	COG2610	gluconate transmembrane transporter activity
NRZ28_18565	COG3835	regulator
NRZ28_18570	COG3112	Uncharacterised protein family (UPF0231)
NRZ28_18585	COG0840	transmembrane signaling receptor activity
NRZ28_18605	COG0513	Belongs to the DEAD box helicase family
NRZ28_18645	COG1448	Aminotransferase
NRZ28_18660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ28_18665	COG1328	CTP reductase activity
NRZ28_18685	COG0793	Belongs to the peptidase S41A family
NRZ28_18685	COG4946	Tricorn protease homolog
NRZ28_18735	COG3397	chitin binding
NRZ28_18740	COG0583	DNA-binding transcription factor activity
NRZ28_18745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRZ28_18750	COG4208	sulfate ABC transporter
NRZ28_18755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NRZ28_18765	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NRZ28_18770	COG3174	membrane
NRZ28_18775	COG0110	maltose O-acetyltransferase activity
NRZ28_18805	COG0165	Argininosuccinate lyase
NRZ28_18810	COG0137	argininosuccinate synthase activity
NRZ28_18820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRZ28_18825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NRZ28_18835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NRZ28_18840	COG0527	aspartate kinase activity
NRZ28_18840	COG0460	homoserine dehydrogenase
NRZ28_18845	COG0626	cystathionine gamma-synthase activity
NRZ28_18855	COG2207	Transcriptional regulator
NRZ28_18855	COG3708	Transcriptional regulator
NRZ28_18860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ28_18865	COG0814	amino acid
NRZ28_18870	COG1218	3'(2'),5'-bisphosphate nucleotidase
NRZ28_18875	COG0494	nUDIX hydrolase
NRZ28_18880	COG1011	Hydrolase
NRZ28_18885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRZ28_18900	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NRZ28_18910	COG3156	type II secretion system protein K
NRZ28_18925	COG4795	General secretion pathway protein
NRZ28_18930	COG2165	general secretion pathway protein
NRZ28_18940	COG2165	general secretion pathway protein
NRZ28_18945	COG1459	type II secretion system
NRZ28_18950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ28_18960	COG3031	protein transport across the cell outer membrane
NRZ28_18970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NRZ28_18975	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NRZ28_18995	COG0456	acetyltransferase
NRZ28_19000	COG3133	Outer membrane lipoprotein
NRZ28_19015	COG2771	luxR family
NRZ28_19020	COG3916	Acyl-homoserine-lactone synthase
NRZ28_19030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NRZ28_19035	COG1309	transcriptional regulator
NRZ28_19045	COG2213	PTS system mannitol-specific
NRZ28_19045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ28_19050	COG0246	Mannitol dehydrogenase
NRZ28_19055	COG3722	fumarate hydratase activity
NRZ28_19060	COG3263	regulation of cellular component size
NRZ28_19085	COG1671	Belongs to the UPF0178 family
NRZ28_19100	COG1988	membrane-bound metal-dependent
NRZ28_19105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ28_19110	COG0513	Belongs to the DEAD box helicase family
NRZ28_19135	COG1575	Belongs to the MenA family. Type 1 subfamily
NRZ28_19140	COG1169	isochorismate synthase
NRZ28_19145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NRZ28_19150	COG0596	Alpha beta hydrolase
NRZ28_19155	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NRZ28_19160	COG1441	menaquinone biosynthetic process
NRZ28_19165	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ28_19185	COG3121	Chaperone
NRZ28_19190	COG3188	usher protein
NRZ28_19200	COG3539	Fimbrial protein
NRZ28_19210	COG3291	Pkd domain containing protein
NRZ28_19215	COG2949	membrane
NRZ28_19220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRZ28_19230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NRZ28_19235	COG5380	lipid catabolic process
NRZ28_19250	COG4533	DNA binding
NRZ28_19260	COG2873	o-acetylhomoserine
NRZ28_19270	COG1979	alcohol dehydrogenase
NRZ28_19290	COG4221	oxidoreductase activity
NRZ28_19310	COG1285	pathogenesis
NRZ28_19330	COG1368	sulfuric ester hydrolase activity
NRZ28_19335	COG1522	sequence-specific DNA binding
NRZ28_19345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NRZ28_19350	COG1418	mRNA catabolic process
NRZ28_19355	COG1058	Belongs to the CinA family
NRZ28_19355	COG1546	Belongs to the CinA family
NRZ28_19365	COG0561	phosphatase activity
NRZ28_19370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRZ28_19390	COG1011	Hydrolase
NRZ28_19405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRZ28_19410	COG0019	diaminopimelate decarboxylase activity
NRZ28_19420	COG1965	Belongs to the frataxin family
NRZ28_19425	COG0400	carboxylic ester hydrolase activity
NRZ28_19430	COG3072	Adenylate cyclase
NRZ28_19435	COG0181	hydroxymethylbilane synthase activity
NRZ28_19445	COG2959	enzyme of heme biosynthesis
NRZ28_19460	COG1494	fructose-1,6-bisphosphatase
NRZ28_19500	COG1733	regulation of RNA biosynthetic process
NRZ28_19520	COG3932	Exopolysaccharide synthesis, ExoD
NRZ28_19525	COG0814	amino acid
NRZ28_19550	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NRZ28_19555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ28_19570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRZ28_19575	COG2022	thiamine diphosphate biosynthetic process
NRZ28_19585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRZ28_19590	COG0352	thiamine-phosphate diphosphorylase activity
NRZ28_19595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NRZ28_19615	COG0745	RESPONSE REGULATOR receiver
NRZ28_19620	COG0642	Histidine kinase
NRZ28_19630	COG0189	ligase activity
NRZ28_19655	COG1639	'signal transduction protein
NRZ28_19665	COG2321	neutral zinc metallopeptidase
NRZ28_19670	COG3700	Belongs to the class B bacterial acid phosphatase family
NRZ28_19690	COG1366	Belongs to the anti-sigma-factor antagonist family
NRZ28_19695	COG2172	sigma factor antagonist activity
NRZ28_19700	COG5002	protein histidine kinase activity
NRZ28_19700	COG2205	protein histidine kinase activity
NRZ28_19700	COG0784	Response regulator, receiver
NRZ28_19705	COG3437	response regulator, receiver
NRZ28_19715	COG0477	Major facilitator Superfamily
NRZ28_19735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NRZ28_19740	COG1263	PTS System
NRZ28_19740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ28_19760	COG0312	modulator of DNA gyrase
NRZ28_19765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRZ28_19780	COG3164	Protein of unknown function
NRZ28_19785	COG1530	ribonuclease E activity
NRZ28_19790	COG0424	maF-like protein
NRZ28_19795	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NRZ28_19800	COG1792	Involved in formation and maintenance of cell shape
NRZ28_19805	COG1077	Cell shape determining protein MreB Mrl
NRZ28_19830	COG4968	Prepilin-type N-terminal cleavage methylation domain
NRZ28_19835	COG4969	Belongs to the N-Me-Phe pilin family
NRZ28_19840	COG2165	general secretion pathway protein
NRZ28_19850	COG1459	type II secretion system
NRZ28_19855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ28_19900	COG2200	EAL domain
NRZ28_19900	COG2199	diguanylate cyclase activity
NRZ28_19905	COG2200	EAL domain
NRZ28_19910	COG0387	Pfam Sodium calcium exchanger
NRZ28_19915	COG2986	histidine ammonia-lyase
NRZ28_19920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NRZ28_19925	COG0010	Belongs to the arginase family
NRZ28_19930	COG1228	amidohydrolase
NRZ28_19935	COG2188	Transcriptional regulator
NRZ28_19940	COG0288	reversible hydration of carbon dioxide
NRZ28_19950	COG2177	Part of the ABC transporter FtsEX involved in
NRZ28_19955	COG2884	Cell division ATP-binding protein ftsE
NRZ28_19960	COG0552	protein localization to endoplasmic reticulum
NRZ28_19965	COG0742	ribosomal rna small subunit methyltransferase
NRZ28_19990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ28_20000	COG0741	lytic transglycosylase activity
NRZ28_20010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRZ28_20020	COG2095	MarC family integral membrane protein
NRZ28_20030	COG1301	dicarboxylic acid transport
NRZ28_20055	COG3714	YhhN family
NRZ28_20080	COG1770	oligopeptidase
NRZ28_20095	COG4221	oxidoreductase activity
NRZ28_20100	COG0583	DNA-binding transcription factor activity
NRZ28_20105	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRZ28_20150	COG0203	ribosomal protein L17
NRZ28_20155	COG0202	RNA polymerase activity
NRZ28_20160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NRZ28_20165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRZ28_20170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRZ28_20175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRZ28_20180	COG0201	protein transport
NRZ28_20185	COG0200	Binds to the 23S rRNA
NRZ28_20190	COG1841	ribosomal large subunit assembly
NRZ28_20195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRZ28_20200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NRZ28_20205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRZ28_20210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRZ28_20215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRZ28_20220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRZ28_20225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NRZ28_20230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRZ28_20235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRZ28_20240	COG0255	Belongs to the universal ribosomal protein uL29 family
NRZ28_20245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NRZ28_20250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRZ28_20255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRZ28_20260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NRZ28_20265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRZ28_20270	COG0089	rRNA binding
NRZ28_20275	COG0088	Forms part of the polypeptide exit tunnel
NRZ28_20280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRZ28_20285	COG0051	transcription antitermination factor activity, RNA binding
NRZ28_20305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRZ28_20310	COG2183	response to ionizing radiation
NRZ28_20330	COG0596	Alpha beta hydrolase
NRZ28_20335	COG1040	competence protein
NRZ28_20340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NRZ28_20340	COG0316	Belongs to the HesB IscA family
NRZ28_20345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRZ28_20350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NRZ28_20355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ28_20360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NRZ28_20365	COG4942	peptidase
NRZ28_20375	COG1609	Transcriptional regulator
NRZ28_20380	COG0800	Aldolase
NRZ28_20385	COG0129	dihydroxy-acid dehydratase activity
NRZ28_20390	COG3265	gluconokinase activity
NRZ28_20395	COG2610	gluconate transmembrane transporter activity
NRZ28_20400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ28_20405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRZ28_20415	COG0456	acetyltransferase
NRZ28_20425	COG1490	D-aminoacyl-tRNA deacylase activity
NRZ28_20435	COG1295	ribonuclease BN
NRZ28_20440	COG1217	gtp-binding protein TYPA
NRZ28_20445	COG0174	glutamine synthetase
NRZ28_20455	COG3852	Histidine kinase
NRZ28_20460	COG2204	response regulator
NRZ28_20465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRZ28_20470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRZ28_20480	COG3078	GTPase activator activity
NRZ28_20490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NRZ28_20500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRZ28_20505	COG0408	coproporphyrinogen oxidase activity
NRZ28_20510	COG0009	L-threonylcarbamoyladenylate synthase
NRZ28_20520	COG0551	DNA topoisomerase type I activity
NRZ28_20525	COG2922	Belongs to the Smg family
NRZ28_20530	COG0758	DNA mediated transformation
NRZ28_20540	COG0242	peptide deformylase activity
NRZ28_20545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRZ28_20550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ28_20550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ28_20555	COG0569	domain protein
NRZ28_20560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ28_20565	COG1322	Protein conserved in bacteria
NRZ28_20585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ28_20590	COG0686	Belongs to the AlaDH PNT family
NRZ28_20595	COG0519	Catalyzes the synthesis of GMP from XMP
NRZ28_20595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRZ28_20605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRZ28_20610	COG1396	sequence-specific DNA binding
NRZ28_20615	COG1012	belongs to the aldehyde dehydrogenase family
NRZ28_20625	COG2962	Rard protein
NRZ28_20635	COG1280	lysine exporter protein (LysE YggA)
NRZ28_20645	COG2391	methyltransferase activity
NRZ28_20680	COG3161	chorismate lyase activity
NRZ28_20705	COG0583	DNA-binding transcription factor activity
NRZ28_20710	COG1943	Transposase
NRZ28_20720	COG0210	DNA helicase
NRZ28_20725	COG1744	ABC transporter substrate-binding protein PnrA-like
NRZ28_20730	COG3845	ABC transporter
NRZ28_20735	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRZ28_20740	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRZ28_20745	COG0583	DNA-binding transcription factor activity
NRZ28_20765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NRZ28_20770	COG0385	Bile acid
NRZ28_20775	COG0531	amino acid
NRZ28_20780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ28_20785	COG0531	amino acid
NRZ28_20790	COG2731	YhcH YjgK YiaL family protein
NRZ28_20795	COG3250	beta-galactosidase activity
NRZ28_20800	COG1609	Transcriptional regulator
NRZ28_20835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NRZ28_20840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ28_20840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ28_20845	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NRZ28_20850	COG3074	FtsZ-dependent cytokinesis
NRZ28_20860	COG1045	serine acetyltransferase
NRZ28_20870	COG0745	RESPONSE REGULATOR receiver
NRZ28_20875	COG2205	protein histidine kinase activity
NRZ28_20880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRZ28_20885	COG0534	Mate efflux family protein
NRZ28_20900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRZ28_20905	COG2937	Belongs to the GPAT DAPAT family
NRZ28_20910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NRZ28_20915	COG3161	chorismate lyase activity
NRZ28_20920	COG1580	Controls the rotational direction of flagella during chemotaxis
NRZ28_20940	COG0604	alcohol dehydrogenase
NRZ28_20945	COG1609	Transcriptional regulator
NRZ28_20965	COG1519	Transferase
NRZ28_20970	COG0859	PFAM glycosyl transferase family 9
NRZ28_20975	COG0463	Glycosyl transferase, family 2
NRZ28_20980	COG0859	PFAM glycosyl transferase family 9
NRZ28_20985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRZ28_20990	COG2990	Protein conserved in bacteria
NRZ28_20995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRZ28_21005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRZ28_21010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRZ28_21015	COG2003	Belongs to the UPF0758 family
NRZ28_21020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRZ28_21025	COG0756	dUTP diphosphatase activity
NRZ28_21030	COG1309	transcriptional regulator
NRZ28_21035	COG0668	transmembrane transport
NRZ28_21045	COG0166	Belongs to the GPI family
NRZ28_21055	COG0583	DNA-binding transcription factor activity
NRZ28_21095	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NRZ28_21100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ28_21105	COG1739	Uncharacterized protein family UPF0029
NRZ28_21110	COG0006	proline dipeptidase activity
NRZ28_21115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRZ28_21120	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ28_21120	COG1024	Enoyl-CoA hydratase
NRZ28_21125	COG0183	Belongs to the thiolase family
NRZ28_21150	COG0425	Belongs to the sulfur carrier protein TusA family
NRZ28_21155	COG0251	oxidation-reduction process
NRZ28_21160	COG2885	chlorophyll binding
NRZ28_21170	COG2818	Glycosylase
NRZ28_21175	COG0752	glycyl-tRNA synthetase alpha subunit
NRZ28_21180	COG0751	glycine-tRNA ligase activity
NRZ28_21195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRZ28_21215	COG0814	amino acid
NRZ28_21220	COG0348	domain, Protein
NRZ28_21225	COG2188	Transcriptional regulator
NRZ28_21240	COG1609	Transcriptional regulator
NRZ28_21280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ28_21305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRZ28_21320	COG3118	belongs to the thioredoxin family
NRZ28_21325	COG0513	Belongs to the DEAD box helicase family
NRZ28_21330	COG0248	Ppx GppA phosphatase
NRZ28_21340	COG0742	ribosomal rna small subunit methyltransferase
NRZ28_21345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ28_21365	COG3397	chitin binding
NRZ28_21375	COG0084	hydrolase, TatD family'
NRZ28_21380	COG0805	protein transport
NRZ28_21385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRZ28_21395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NRZ28_21400	COG3165	ubiquinone biosynthetic process from chorismate
NRZ28_21410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRZ28_21415	COG0402	S-adenosylhomocysteine deaminase activity
NRZ28_21455	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NRZ28_21460	COG0848	biopolymer transport protein
NRZ28_21465	COG0811	peptide transport
NRZ28_21470	COG0811	peptide transport
NRZ28_21480	COG2771	luxR family
NRZ28_21485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRZ28_21490	COG1349	DNA-binding transcription factor activity
NRZ28_21495	COG0745	RESPONSE REGULATOR receiver
NRZ28_21500	COG2205	protein histidine kinase activity
NRZ28_21510	COG4452	Inner membrane protein CreD
NRZ28_21515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NRZ28_21520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NRZ28_21525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRZ28_21530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRZ28_21535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRZ28_21540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRZ28_21545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRZ28_21555	COG0356	it plays a direct role in the translocation of protons across the membrane
NRZ28_21565	COG1475	DNA binding
NRZ28_21570	COG1192	Involved in chromosome partitioning
NRZ28_21575	COG0357	Ribosomal RNA small subunit methyltransferase G
NRZ28_21580	COG0445	tRNA wobble uridine modification
NRZ28_21585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRZ28_21590	COG4774	siderophore transport
NRZ28_21595	COG4615	Cyclic peptide transporter
NRZ28_21600	COG1120	ATPase activity
NRZ28_21615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRZ28_21620	COG0706	membrane insertase activity
NRZ28_21625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRZ28_21630	COG0594	ribonuclease P activity
NRZ28_21635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NRZ28_21640	COG1126	abc transporter atp-binding protein