locus-tag	class	description
AhyD4_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AhyD4_00010	COG0592	DNA-directed DNA polymerase activity
AhyD4_00020	COG0187	DNA topoisomerase II activity
AhyD4_00030	COG2378	regulation of single-species biofilm formation
AhyD4_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
AhyD4_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
AhyD4_00045	COG3977	Valine--pyruvate aminotransferase
AhyD4_00060	COG2814	Major facilitator Superfamily
AhyD4_00065	COG0745	RESPONSE REGULATOR receiver
AhyD4_00070	COG2205	protein histidine kinase activity
AhyD4_00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhyD4_00095	COG4191	Histidine kinase
AhyD4_00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_00110	COG1309	transcriptional regulator
AhyD4_00140	COG0469	pyruvate kinase activity
AhyD4_00145	COG2271	Major facilitator Superfamily
AhyD4_00150	COG1840	ABC-type Fe3 transport system, periplasmic component
AhyD4_00170	COG0561	phosphatase activity
AhyD4_00175	COG2267	carboxylic ester hydrolase activity
AhyD4_00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhyD4_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhyD4_00195	COG1758	RNA polymerase activity
AhyD4_00205	COG0859	PFAM glycosyl transferase family 9
AhyD4_00210	COG3642	lipopolysaccharide core region biosynthetic process
AhyD4_00245	COG0589	response to stress
AhyD4_00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AhyD4_00255	COG2199	diguanylate cyclase activity
AhyD4_00260	COG1528	Iron-storage protein
AhyD4_00265	COG2081	HI0933 family
AhyD4_00270	COG2223	nitrite transmembrane transporter activity
AhyD4_00290	COG3188	usher protein
AhyD4_00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_00310	COG2205	protein histidine kinase activity
AhyD4_00320	COG3275	phosphorelay sensor kinase activity
AhyD4_00325	COG3279	Response regulator of the LytR AlgR family
AhyD4_00330	COG2223	nitrite transmembrane transporter activity
AhyD4_00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AhyD4_00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AhyD4_00355	COG0583	DNA-binding transcription factor activity
AhyD4_00360	COG4206	TonB-dependent receptor
AhyD4_00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AhyD4_00470	COG2003	Belongs to the UPF0758 family
AhyD4_00515	COG3311	Transcriptional regulator
AhyD4_00535	COG2771	luxR family
AhyD4_00545	COG3501	Rhs element vgr protein
AhyD4_00585	COG1358	cellular component organization or biogenesis
AhyD4_00645	COG0582	viral genome integration into host DNA
AhyD4_00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AhyD4_00655	COG2166	iron-sulfur cluster assembly
AhyD4_00660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AhyD4_00665	COG0210	DNA helicase
AhyD4_00675	COG3245	cytochrome
AhyD4_00680	COG1063	alcohol dehydrogenase
AhyD4_00685	COG0156	8-amino-7-oxononanoate synthase activity
AhyD4_00695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_00710	COG3306	glycosyltransferase involved in LPS biosynthesis
AhyD4_00730	COG1561	YicC-like family, N-terminal region
AhyD4_00735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AhyD4_00740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AhyD4_00750	COG0789	Transcriptional regulator
AhyD4_00755	COG4251	negative regulation of phosphorylation
AhyD4_00755	COG5001	Diguanylate cyclase
AhyD4_00755	COG3706	GGDEF domain
AhyD4_00755	COG2203	Gaf domain
AhyD4_00760	COG3084	Protein conserved in bacteria
AhyD4_00770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AhyD4_00775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_00780	COG3639	organic phosphonate transmembrane transporter activity
AhyD4_00785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AhyD4_00790	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AhyD4_00800	COG1335	isochorismatase
AhyD4_00810	COG1683	Conserved Protein
AhyD4_00815	COG0204	Acyl-transferase
AhyD4_00820	COG0204	Acyl-transferase
AhyD4_00825	COG0606	chelatase, subunit chli
AhyD4_00835	COG3978	acetolactate synthase activity
AhyD4_00840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AhyD4_00845	COG0129	dihydroxy-acid dehydratase activity
AhyD4_00865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AhyD4_00870	COG0254	rRNA binding
AhyD4_00875	COG0702	epimerase
AhyD4_00880	COG0281	malic enzyme
AhyD4_00890	COG2205	protein histidine kinase activity
AhyD4_00895	COG0745	RESPONSE REGULATOR receiver
AhyD4_00900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_00915	COG0366	Alpha amylase catalytic
AhyD4_00930	COG0443	Heat shock 70 kDa protein
AhyD4_00935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AhyD4_00940	COG3045	CreA protein
AhyD4_00955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AhyD4_00960	COG0174	glutamine synthetase
AhyD4_00980	COG3842	ATPase activity
AhyD4_00985	COG1176	ABC-type spermidine putrescine transport system, permease component I
AhyD4_00990	COG1177	transmembrane transport
AhyD4_00995	COG2258	MOSC domain
AhyD4_01010	COG2050	protein possibly involved in aromatic compounds catabolism
AhyD4_01015	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_01025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AhyD4_01035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AhyD4_01040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AhyD4_01050	COG2239	Acts as a magnesium transporter
AhyD4_01055	COG1648	precorrin-2 dehydrogenase activity
AhyD4_01055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_01060	COG2116	formate transmembrane transporter activity
AhyD4_01065	COG2146	nitrite reductase [NAD(P)H] activity
AhyD4_01070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_01085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AhyD4_01090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AhyD4_01110	COG1595	DNA-templated transcription, initiation
AhyD4_01115	COG3806	Anti-sigma factor
AhyD4_01120	COG1968	undecaprenyl-diphosphatase activity
AhyD4_01125	COG0667	Aldo Keto reductase
AhyD4_01130	COG2017	converts alpha-aldose to the beta-anomer
AhyD4_01135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AhyD4_01145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AhyD4_01150	COG1609	Transcriptional regulator
AhyD4_01155	COG3250	beta-galactosidase activity
AhyD4_01175	COG0840	transmembrane signaling receptor activity
AhyD4_01200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AhyD4_01205	COG1288	antiporter activity
AhyD4_01210	COG1438	arginine binding
AhyD4_01215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AhyD4_01220	COG0540	Belongs to the ATCase OTCase family
AhyD4_01235	COG0688	phosphatidylethanolamine metabolic process
AhyD4_01250	COG2207	Transcriptional regulator
AhyD4_01255	COG1979	alcohol dehydrogenase
AhyD4_01260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AhyD4_01265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AhyD4_01275	COG2964	Protein conserved in bacteria
AhyD4_01280	COG3681	Belongs to the UPF0597 family
AhyD4_01290	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_01295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_01300	COG0564	pseudouridine synthase activity
AhyD4_01310	COG0542	response to heat
AhyD4_01315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AhyD4_01320	COG2502	aspartate--ammonia ligase
AhyD4_01325	COG1522	sequence-specific DNA binding
AhyD4_01335	COG5413	integral membrane protein
AhyD4_01355	COG2205	protein histidine kinase activity
AhyD4_01365	COG2204	response regulator
AhyD4_01380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AhyD4_01395	COG0745	RESPONSE REGULATOR receiver
AhyD4_01400	COG2205	protein histidine kinase activity
AhyD4_01410	COG0243	molybdopterin cofactor binding
AhyD4_01415	COG3005	denitrification pathway
AhyD4_01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AhyD4_01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_01445	COG0569	domain protein
AhyD4_01450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AhyD4_01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhyD4_01485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AhyD4_01490	COG0250	Participates in transcription elongation, termination and antitermination
AhyD4_01495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AhyD4_01500	COG0081	regulation of translation
AhyD4_01505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AhyD4_01510	COG0222	ribosome binding
AhyD4_01515	COG0085	RNA polymerase activity
AhyD4_01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AhyD4_01530	COG2964	Protein conserved in bacteria
AhyD4_01535	COG0251	oxidation-reduction process
AhyD4_01545	COG2923	Belongs to the DsrF TusC family
AhyD4_01550	COG2168	tRNA wobble position uridine thiolation
AhyD4_01560	COG0049	tRNA binding
AhyD4_01565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AhyD4_01570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhyD4_01575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AhyD4_01615	COG2252	PERMEase
AhyD4_01620	COG2376	Dihydroxyacetone kinase
AhyD4_01625	COG1461	Dihydroxyacetone kinase
AhyD4_01640	COG3284	Transcriptional regulator
AhyD4_01650	COG2957	Belongs to the agmatine deiminase family
AhyD4_01655	COG4221	oxidoreductase activity
AhyD4_01660	COG0628	permease
AhyD4_01665	COG0494	nUDIX hydrolase
AhyD4_01690	COG0753	catalase activity
AhyD4_01695	COG1247	-acetyltransferase
AhyD4_01715	COG3706	GGDEF domain
AhyD4_01725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AhyD4_01735	COG1175	transmembrane transport
AhyD4_01760	COG0583	DNA-binding transcription factor activity
AhyD4_01770	COG1741	Belongs to the pirin family
AhyD4_01775	COG2259	Doxx family
AhyD4_01780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AhyD4_01785	COG1074	ATP-dependent DNA helicase activity
AhyD4_01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AhyD4_01795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AhyD4_01800	COG0346	lactoylglutathione lyase activity
AhyD4_01835	COG0745	RESPONSE REGULATOR receiver
AhyD4_01840	COG2205	protein histidine kinase activity
AhyD4_01845	COG5001	Diguanylate cyclase
AhyD4_01845	COG2203	Gaf domain
AhyD4_01845	COG4251	negative regulation of phosphorylation
AhyD4_01845	COG3706	GGDEF domain
AhyD4_01850	COG4771	TonB-dependent receptor
AhyD4_01855	COG1278	Cold shock
AhyD4_01875	COG0629	single-stranded DNA binding
AhyD4_01880	COG2197	response regulator
AhyD4_01885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AhyD4_01895	COG3047	cAMP biosynthetic process
AhyD4_01900	COG0840	transmembrane signaling receptor activity
AhyD4_01925	COG3135	benzoate transporter
AhyD4_01930	COG1396	sequence-specific DNA binding
AhyD4_01960	COG2926	Belongs to the UPF0265 family
AhyD4_01970	COG3028	Belongs to the UPF0307 family
AhyD4_01975	COG0312	modulator of DNA gyrase
AhyD4_01980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AhyD4_01985	COG5007	Belongs to the BolA IbaG family
AhyD4_01995	COG2854	intermembrane phospholipid transfer
AhyD4_02000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AhyD4_02005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AhyD4_02010	COG1127	ABC transporter
AhyD4_02015	COG0517	IMP dehydrogenase activity
AhyD4_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhyD4_02020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AhyD4_02025	COG3117	lipopolysaccharide transmembrane transporter activity
AhyD4_02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AhyD4_02035	COG1137	ATPase activity
AhyD4_02040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AhyD4_02050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_02055	COG1660	Displays ATPase and GTPase activities
AhyD4_02060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_02065	COG3711	transcriptional antiterminator
AhyD4_02080	COG3964	amidohydrolase
AhyD4_02110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhyD4_02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhyD4_02125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AhyD4_02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AhyD4_02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AhyD4_02140	COG0723	plastoquinol--plastocyanin reductase activity
AhyD4_02145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AhyD4_02150	COG2857	Cytochrome c1
AhyD4_02155	COG0625	glutathione transferase activity
AhyD4_02160	COG2969	positive regulation of protein catabolic process
AhyD4_02165	COG2823	Periplasmic or secreted lipoprotein
AhyD4_02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AhyD4_02175	COG0792	nuclease activity
AhyD4_02180	COG3107	peptidoglycan biosynthetic process
AhyD4_02185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AhyD4_02195	COG2001	Belongs to the MraZ family
AhyD4_02200	COG0275	rRNA processing
AhyD4_02205	COG3116	cell division
AhyD4_02210	COG0768	penicillin binding
AhyD4_02220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AhyD4_02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AhyD4_02230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AhyD4_02235	COG0772	Belongs to the SEDS family
AhyD4_02240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AhyD4_02245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AhyD4_02250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AhyD4_02255	COG0849	cell division
AhyD4_02260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AhyD4_02265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AhyD4_02275	COG0653	protein targeting
AhyD4_02285	COG0494	nUDIX hydrolase
AhyD4_02290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AhyD4_02295	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AhyD4_02310	COG1459	type II secretion system
AhyD4_02315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_02340	COG2186	Transcriptional regulator
AhyD4_02345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AhyD4_02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AhyD4_02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhyD4_02360	COG5002	protein histidine kinase activity
AhyD4_02360	COG5001	Diguanylate cyclase
AhyD4_02360	COG3447	MASE1 domain protein
AhyD4_02370	COG0840	transmembrane signaling receptor activity
AhyD4_02375	COG0840	transmembrane signaling receptor activity
AhyD4_02380	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhyD4_02385	COG1049	propionate catabolic process, 2-methylcitrate cycle
AhyD4_02400	COG1280	lysine exporter protein (LysE YggA)
AhyD4_02410	COG0523	cobalamin synthesis protein
AhyD4_02415	COG0477	Major facilitator Superfamily
AhyD4_02430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AhyD4_02435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AhyD4_02480	COG0835	chemotaxis
AhyD4_02480	COG0784	Response regulator, receiver
AhyD4_02485	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_02490	COG1444	tRNA N-acetyltransferase activity
AhyD4_02515	COG1803	Methylglyoxal synthase
AhyD4_02530	COG0252	asparaginase activity
AhyD4_02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_02550	COG1263	PTS System
AhyD4_02555	COG0366	Alpha amylase catalytic
AhyD4_02560	COG0110	maltose O-acetyltransferase activity
AhyD4_02565	COG1522	sequence-specific DNA binding
AhyD4_02570	COG5006	permease, DMT superfamily
AhyD4_02580	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_02585	COG1177	transmembrane transport
AhyD4_02590	COG1176	ABC-type spermidine putrescine transport system, permease component I
AhyD4_02595	COG3842	ATPase activity
AhyD4_02600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AhyD4_02605	COG0583	DNA-binding transcription factor activity
AhyD4_02610	COG1757	Na H antiporter
AhyD4_02650	COG0297	glycogen (starch) synthase activity
AhyD4_02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_02660	COG2813	Specifically methylates the guanine in position
AhyD4_02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_02670	COG2203	Gaf domain
AhyD4_02670	COG3706	GGDEF domain
AhyD4_02670	COG4251	negative regulation of phosphorylation
AhyD4_02670	COG5001	Diguanylate cyclase
AhyD4_02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_02690	COG2995	paraquat-inducible protein a
AhyD4_02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AhyD4_02695	COG3008	intermembrane lipid transfer
AhyD4_02700	COG3009	Protein conserved in bacteria
AhyD4_02705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AhyD4_02705	COG2885	chlorophyll binding
AhyD4_02715	COG3240	lipase activity
AhyD4_02720	COG3111	PFAM Bacterial OB fold (BOF) protein
AhyD4_02730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AhyD4_02735	COG1194	a g-specific adenine glycosylase
AhyD4_02745	COG3409	Peptidoglycan-binding domain 1 protein
AhyD4_02745	COG3267	Type II secretory pathway component ExeA
AhyD4_02755	COG0617	tRNA 3'-terminal CCA addition
AhyD4_02770	COG1346	cytolysis
AhyD4_02775	COG1380	Effector of murein hydrolase LrgA
AhyD4_02780	COG0583	DNA-binding transcription factor activity
AhyD4_02805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AhyD4_02810	COG0306	phosphate transporter
AhyD4_02815	COG1392	Phosphate transport regulator
AhyD4_02830	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_02835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AhyD4_02835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AhyD4_02840	COG1538	Outer membrane efflux protein
AhyD4_02845	COG0494	nUDIX hydrolase
AhyD4_02850	COG3151	Protein conserved in bacteria
AhyD4_02860	COG3150	esterase
AhyD4_02865	COG1051	belongs to the nudix hydrolase family
AhyD4_02880	COG1566	PFAM secretion protein HlyD family protein
AhyD4_02885	COG1289	transmembrane transporter activity
AhyD4_02890	COG0187	DNA topoisomerase II activity
AhyD4_02935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AhyD4_02960	COG0204	Acyl-transferase
AhyD4_02965	COG1842	Phage shock protein A
AhyD4_02980	COG2827	Endonuclease containing a URI domain
AhyD4_02990	COG2962	Rard protein
AhyD4_02995	COG1573	uracil-dna glycosylase
AhyD4_03000	COG0697	spore germination
AhyD4_03010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AhyD4_03015	COG1121	(ABC) transporter
AhyD4_03020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AhyD4_03040	COG0739	heme binding
AhyD4_03050	COG3068	Protein conserved in bacteria
AhyD4_03070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AhyD4_03085	COG1546	Belongs to the CinA family
AhyD4_03090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AhyD4_03100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AhyD4_03105	COG0527	aspartate kinase activity
AhyD4_03110	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AhyD4_03145	COG1686	Belongs to the peptidase S11 family
AhyD4_03150	COG0586	Pfam SNARE associated Golgi protein
AhyD4_03155	COG1253	flavin adenine dinucleotide binding
AhyD4_03160	COG0525	valine-tRNA ligase activity
AhyD4_03165	COG2927	DNA polymerase III (CHI subunit)
AhyD4_03170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_03175	COG0795	lipopolysaccharide-transporting ATPase activity
AhyD4_03180	COG0795	lipopolysaccharide-transporting ATPase activity
AhyD4_03195	COG0582	viral genome integration into host DNA
AhyD4_03210	COG3561	AntA/AntB antirepressor
AhyD4_03235	COG0004	ammonium transporteR
AhyD4_03240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_03250	COG0084	hydrolase, TatD family'
AhyD4_03255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_03265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AhyD4_03270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AhyD4_03275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AhyD4_03280	COG0813	purine-nucleoside phosphorylase activity
AhyD4_03285	COG3447	MASE1 domain protein
AhyD4_03285	COG5001	Diguanylate cyclase
AhyD4_03285	COG5002	protein histidine kinase activity
AhyD4_03295	COG0560	Phosphoserine phosphatase
AhyD4_03320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AhyD4_03325	COG0776	regulation of translation
AhyD4_03335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AhyD4_03365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AhyD4_03370	COG0513	Belongs to the DEAD box helicase family
AhyD4_03375	COG3022	response to hydroperoxide
AhyD4_03390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AhyD4_03395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AhyD4_03400	COG0762	integral membrane protein
AhyD4_03405	COG1872	DUF167
AhyD4_03420	COG4166	transmembrane transport
AhyD4_03430	COG0110	maltose O-acetyltransferase activity
AhyD4_03440	COG1024	Enoyl-CoA hydratase
AhyD4_03455	COG4221	oxidoreductase activity
AhyD4_03460	COG0442	prolyl-tRNA aminoacylation
AhyD4_03465	COG0840	transmembrane signaling receptor activity
AhyD4_03470	COG0632	four-way junction helicase activity
AhyD4_03475	COG2255	four-way junction helicase activity
AhyD4_03480	COG1271	oxidase subunit
AhyD4_03485	COG1294	oxidase, subunit
AhyD4_03490	COG4890	Cyd operon protein YbgT
AhyD4_03495	COG3790	cyd operon protein YbgE
AhyD4_03500	COG0824	Thioesterase
AhyD4_03505	COG0811	peptide transport
AhyD4_03520	COG0823	Involved in the tonB-independent uptake of proteins
AhyD4_03525	COG2885	chlorophyll binding
AhyD4_03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AhyD4_03585	COG0840	transmembrane signaling receptor activity
AhyD4_03590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AhyD4_03595	COG0676	glucose-6-phosphate 1-epimerase activity
AhyD4_03600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AhyD4_03605	COG1640	4-alpha-glucanotransferase
AhyD4_03610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AhyD4_03630	COG1051	belongs to the nudix hydrolase family
AhyD4_03635	COG2130	NADP-dependent
AhyD4_03640	COG1764	response to oxidative stress
AhyD4_03645	COG1846	Transcriptional regulator
AhyD4_03660	COG1522	sequence-specific DNA binding
AhyD4_03675	COG0561	phosphatase activity
AhyD4_03690	COG0733	neurotransmitter:sodium symporter activity
AhyD4_03700	COG0733	neurotransmitter:sodium symporter activity
AhyD4_03725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_03740	COG1794	racemase activity, acting on amino acids and derivatives
AhyD4_03755	COG2731	YhcH YjgK YiaL family protein
AhyD4_03765	COG0668	transmembrane transport
AhyD4_03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_03810	COG0583	DNA-binding transcription factor activity
AhyD4_03815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AhyD4_03825	COG0488	(ABC) transporter
AhyD4_03830	COG0517	IMP dehydrogenase activity
AhyD4_03830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhyD4_03835	COG1585	Membrane protein implicated in regulation of membrane protease activity
AhyD4_03840	COG0330	HflC and HflK could
AhyD4_03845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_03845	COG1648	precorrin-2 dehydrogenase activity
AhyD4_03850	COG0175	sulfate reduction
AhyD4_03855	COG2895	sulfate adenylyltransferase (ATP) activity
AhyD4_03860	COG3273	potassium ion transport
AhyD4_03860	COG0471	metal ion transport
AhyD4_03865	COG0529	Catalyzes the synthesis of activated sulfate
AhyD4_03885	COG0840	transmembrane signaling receptor activity
AhyD4_03920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AhyD4_03935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AhyD4_03940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AhyD4_03945	COG0163	prenyltransferase activity
AhyD4_03960	COG1131	(ABC) transporter
AhyD4_03965	COG0842	Transport permease protein
AhyD4_03970	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AhyD4_03975	COG1924	4 iron, 4 sulfur cluster binding
AhyD4_03995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AhyD4_04000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AhyD4_04015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_04020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AhyD4_04025	COG1489	DNA binding
AhyD4_04035	COG1643	Atp-dependent helicase
AhyD4_04040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AhyD4_04045	COG0346	lactoylglutathione lyase activity
AhyD4_04055	COG2076	Multidrug Resistance protein
AhyD4_04065	COG3437	response regulator, receiver
AhyD4_04065	COG0784	Response regulator, receiver
AhyD4_04075	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_04090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AhyD4_04095	COG0038	chloride channel
AhyD4_04105	COG0316	Belongs to the HesB IscA family
AhyD4_04130	COG1280	lysine exporter protein (LysE YggA)
AhyD4_04135	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AhyD4_04150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_04180	COG0745	RESPONSE REGULATOR receiver
AhyD4_04185	COG3104	oligopeptide transport
AhyD4_04190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AhyD4_04195	COG1555	photosystem II stabilization
AhyD4_04205	COG2350	Protein conserved in bacteria
AhyD4_04210	COG2917	probably involved in intracellular septation
AhyD4_04215	COG0076	glutamate decarboxylase activity
AhyD4_04220	COG1272	protein, Hemolysin III
AhyD4_04225	COG2985	domain, Protein
AhyD4_04225	COG0569	domain protein
AhyD4_04240	COG0835	chemotaxis
AhyD4_04240	COG0784	Response regulator, receiver
AhyD4_04245	COG2755	lipolytic protein G-D-S-L family
AhyD4_04250	COG4181	ATPase activity
AhyD4_04255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AhyD4_04260	COG1090	epimerase
AhyD4_04265	COG2200	EAL domain
AhyD4_04270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_04275	COG4935	Belongs to the peptidase S8 family
AhyD4_04275	COG2234	aminopeptidase activity
AhyD4_04280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AhyD4_04285	COG3171	Protein conserved in bacteria
AhyD4_04290	COG2066	Belongs to the glutaminase family
AhyD4_04295	COG2897	thiosulfate sulfurtransferase activity
AhyD4_04300	COG1404	Belongs to the peptidase S8 family
AhyD4_04310	COG1132	(ABC) transporter
AhyD4_04330	COG3291	Pkd domain containing protein
AhyD4_04330	COG4412	M6 family metalloprotease domain protein
AhyD4_04335	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AhyD4_04340	COG3300	MHYT domain
AhyD4_04340	COG5001	Diguanylate cyclase
AhyD4_04360	COG4628	conserved protein (DUF2132)
AhyD4_04365	COG0688	phosphatidylethanolamine metabolic process
AhyD4_04370	COG1162	GTPase activity
AhyD4_04375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AhyD4_04410	COG1278	Cold shock
AhyD4_04420	COG0840	transmembrane signaling receptor activity
AhyD4_04425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_04430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_04475	COG0848	biopolymer transport protein
AhyD4_04480	COG0811	peptide transport
AhyD4_04485	COG0811	peptide transport
AhyD4_04500	COG4174	ABC transporter (Permease)
AhyD4_04505	COG4239	(ABC) transporter, permease
AhyD4_04515	COG0444	Belongs to the ABC transporter superfamily
AhyD4_04520	COG4608	Belongs to the ABC transporter superfamily
AhyD4_04525	COG2195	Cleaves the N-terminal amino acid of tripeptides
AhyD4_04530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AhyD4_04550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AhyD4_04575	COG0243	molybdopterin cofactor binding
AhyD4_04590	COG1116	anion transmembrane transporter activity
AhyD4_04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhyD4_04595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhyD4_04600	COG1116	anion transmembrane transporter activity
AhyD4_04605	COG2146	nitrite reductase [NAD(P)H] activity
AhyD4_04605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_04610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_04610	COG2146	nitrite reductase [NAD(P)H] activity
AhyD4_04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_04620	COG2313	pseudouridylate synthase activity
AhyD4_04630	COG1858	cytochrome C peroxidase
AhyD4_04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_04670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_04695	COG2986	histidine ammonia-lyase
AhyD4_04720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AhyD4_04730	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_04745	COG0521	Mo-molybdopterin cofactor biosynthetic process
AhyD4_04755	COG2966	Psort location CytoplasmicMembrane, score
AhyD4_04760	COG3610	response to peptide
AhyD4_04770	COG4175	Glycine betaine
AhyD4_04775	COG4176	ABC-type proline glycine betaine transport system permease component
AhyD4_04780	COG2113	Glycine betaine
AhyD4_04785	COG0175	sulfate reduction
AhyD4_04790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_04795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AhyD4_04800	COG0384	phenazine biosynthesis protein PhzF
AhyD4_04805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AhyD4_04810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AhyD4_04820	COG0786	glutamate:sodium symporter activity
AhyD4_04825	COG0252	asparaginase activity
AhyD4_04830	COG3139	Protein of unknown function (DUF1315)
AhyD4_04850	COG0616	signal peptide processing
AhyD4_04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_04855	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_04860	COG0778	Nitroreductase
AhyD4_04875	COG2264	protein methyltransferase activity
AhyD4_04880	COG0604	alcohol dehydrogenase
AhyD4_04885	COG0583	DNA-binding transcription factor activity
AhyD4_04890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_04890	COG1263	PTS System
AhyD4_04890	COG2190	(PTS) system
AhyD4_04895	COG4145	pantothenate transmembrane transporter activity
AhyD4_04905	COG0439	Biotin carboxylase
AhyD4_04910	COG0511	ligase activity, forming carbon-carbon bonds
AhyD4_04915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AhyD4_04920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhyD4_04930	COG5001	Diguanylate cyclase
AhyD4_04930	COG3300	MHYT domain
AhyD4_04950	COG3381	protein complex oligomerization
AhyD4_04965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AhyD4_04980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AhyD4_04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhyD4_04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhyD4_05005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AhyD4_05010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_05015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AhyD4_05020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AhyD4_05045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AhyD4_05050	COG0142	geranyltranstransferase activity
AhyD4_05055	COG1722	exodeoxyribonuclease VII activity
AhyD4_05060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_05065	COG1360	Flagellar Motor Protein
AhyD4_05070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhyD4_05080	COG1534	Rna-binding protein
AhyD4_05085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AhyD4_05090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AhyD4_05095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AhyD4_05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AhyD4_05105	COG0149	triose-phosphate isomerase activity
AhyD4_05110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AhyD4_05125	COG0779	Required for maturation of 30S ribosomal subunits
AhyD4_05130	COG0195	Participates in both transcription termination and antitermination
AhyD4_05135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AhyD4_05140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AhyD4_05145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AhyD4_05150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AhyD4_05155	COG1185	polyribonucleotide nucleotidyltransferase activity
AhyD4_05170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AhyD4_05180	COG0114	fumarate hydratase activity
AhyD4_05190	COG1966	Carbon starvation protein
AhyD4_05195	COG3279	Response regulator of the LytR AlgR family
AhyD4_05265	COG0312	modulator of DNA gyrase
AhyD4_05270	COG0312	modulator of DNA gyrase
AhyD4_05275	COG0716	FMN binding
AhyD4_05280	COG4974	Belongs to the 'phage' integrase family
AhyD4_05285	COG1970	mechanosensitive ion channel activity
AhyD4_05290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_05300	COG0789	Transcriptional regulator
AhyD4_05315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_05320	COG3545	Serine hydrolase
AhyD4_05330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AhyD4_05335	COG0321	lipoyl(octanoyl) transferase activity
AhyD4_05340	COG2921	Belongs to the UPF0250 family
AhyD4_05345	COG1686	Belongs to the peptidase S11 family
AhyD4_05350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AhyD4_05355	COG2951	lytic endotransglycosylase activity
AhyD4_05360	COG0772	Belongs to the SEDS family
AhyD4_05365	COG0768	penicillin binding
AhyD4_05370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AhyD4_05375	COG0799	negative regulation of ribosome biogenesis
AhyD4_05380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AhyD4_05395	COG0495	leucyl-tRNA aminoacylation
AhyD4_05400	COG2888	peptidyl-tyrosine sulfation
AhyD4_05405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AhyD4_05410	COG4535	Mg2 and Co2 transporter CorC
AhyD4_05415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AhyD4_05420	COG1702	phosphate starvation-inducible protein PhoH
AhyD4_05425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AhyD4_05430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_05435	COG1335	isochorismatase
AhyD4_05445	COG3706	GGDEF domain
AhyD4_05460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_05470	COG3706	GGDEF domain
AhyD4_05480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AhyD4_05490	COG3647	Membrane
AhyD4_05495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AhyD4_05505	COG0516	GMP reductase activity
AhyD4_05515	COG0642	Histidine kinase
AhyD4_05520	COG0745	RESPONSE REGULATOR receiver
AhyD4_05555	COG3214	Protein conserved in bacteria
AhyD4_05580	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AhyD4_05585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AhyD4_05590	COG1053	succinate dehydrogenase
AhyD4_05600	COG0584	glycerophosphoryl diester phosphodiesterase
AhyD4_05605	COG1511	domain protein
AhyD4_05605	COG3264	Mechanosensitive ion channel
AhyD4_05615	COG0739	heme binding
AhyD4_05630	COG0583	DNA-binding transcription factor activity
AhyD4_05650	COG0583	DNA-binding transcription factor activity
AhyD4_05655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AhyD4_05685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AhyD4_05690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AhyD4_05700	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AhyD4_05705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AhyD4_05715	COG0180	Tryptophanyl-tRNA synthetase
AhyD4_05730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AhyD4_05740	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_05750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_05760	COG0674	pyruvate-flavodoxin oxidoreductase activity
AhyD4_05760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AhyD4_05760	COG1013	pyruvate-flavodoxin oxidoreductase activity
AhyD4_05760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_05770	COG0366	Alpha amylase catalytic
AhyD4_05790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AhyD4_05800	COG0471	metal ion transport
AhyD4_05800	COG0490	domain, Protein
AhyD4_05845	COG0012	GTP binding
AhyD4_05850	COG0193	aminoacyl-tRNA hydrolase activity
AhyD4_05855	COG0737	Belongs to the 5'-nucleotidase family
AhyD4_05860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AhyD4_05875	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AhyD4_05880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AhyD4_05885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AhyD4_05890	COG2890	protein-(glutamine-N5) methyltransferase activity
AhyD4_05900	COG2912	Transglutaminase-like superfamily
AhyD4_05905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AhyD4_05910	COG1301	dicarboxylic acid transport
AhyD4_05920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AhyD4_05935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AhyD4_05940	COG1115	amino acid carrier protein
AhyD4_05955	COG0714	Associated with various cellular activities
AhyD4_05965	COG3104	oligopeptide transport
AhyD4_05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AhyD4_05975	COG1678	Uncharacterized ACR, COG1678
AhyD4_05985	COG0189	ligase activity
AhyD4_05990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AhyD4_06000	COG3091	SprT-like family
AhyD4_06010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AhyD4_06020	COG2200	EAL domain
AhyD4_06045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AhyD4_06050	COG0739	heme binding
AhyD4_06055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AhyD4_06060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AhyD4_06060	COG3408	Glycogen debranching enzyme
AhyD4_06070	COG1881	PFAM PEBP family protein
AhyD4_06080	COG0583	DNA-binding transcription factor activity
AhyD4_06090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AhyD4_06100	COG0583	DNA-binding transcription factor activity
AhyD4_06105	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_06110	COG0616	signal peptide processing
AhyD4_06115	COG3724	N-succinylarginine dihydrolase activity
AhyD4_06120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AhyD4_06135	COG0840	transmembrane signaling receptor activity
AhyD4_06145	COG2971	BadF BadG BcrA BcrD
AhyD4_06155	COG4608	Belongs to the ABC transporter superfamily
AhyD4_06160	COG0444	Belongs to the ABC transporter superfamily
AhyD4_06165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_06170	COG0601	transmembrane transport
AhyD4_06175	COG4166	transmembrane transport
AhyD4_06210	COG3220	belongs to the UPF0276 family
AhyD4_06240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_06245	COG1289	transmembrane transporter activity
AhyD4_06250	COG0303	'Molybdopterin
AhyD4_06255	COG0746	molybdenum cofactor guanylyltransferase activity
AhyD4_06265	COG4662	Binding-protein-dependent transport system inner membrane component
AhyD4_06275	COG2204	response regulator
AhyD4_06280	COG3852	Histidine kinase
AhyD4_06285	COG1910	domain protein
AhyD4_06290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AhyD4_06325	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_06325	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_06330	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_06345	COG0281	malic enzyme
AhyD4_06365	COG2706	6-phosphogluconolactonase activity
AhyD4_06375	COG3264	Mechanosensitive ion channel
AhyD4_06375	COG1196	nuclear chromosome segregation
AhyD4_06380	COG0469	pyruvate kinase activity
AhyD4_06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhyD4_06395	COG4651	solute:proton antiporter activity
AhyD4_06405	COG2974	May be involved in recombination
AhyD4_06415	COG0420	3'-5' exonuclease activity
AhyD4_06420	COG0419	ATPase involved in DNA repair
AhyD4_06435	COG3038	cytochrome b561
AhyD4_06450	COG2190	(PTS) system
AhyD4_06460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_06465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AhyD4_06470	COG0542	response to heat
AhyD4_06485	COG1720	tRNA m6t6A37 methyltransferase activity
AhyD4_06505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AhyD4_06510	COG4988	ABC transporter
AhyD4_06525	COG0745	RESPONSE REGULATOR receiver
AhyD4_06535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AhyD4_06550	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AhyD4_06555	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AhyD4_06565	COG0083	homoserine kinase activity
AhyD4_06570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AhyD4_06575	COG4319	ketosteroid isomerase
AhyD4_06590	COG0488	(ABC) transporter
AhyD4_06600	COG0813	purine-nucleoside phosphorylase activity
AhyD4_06615	COG2205	protein histidine kinase activity
AhyD4_06615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_06620	COG3384	dioxygenase
AhyD4_06630	COG1283	sodium-dependent phosphate transmembrane transporter activity
AhyD4_06640	COG0531	amino acid
AhyD4_06650	COG0531	amino acid
AhyD4_06665	COG1396	sequence-specific DNA binding
AhyD4_06665	COG1917	Cupin 2, conserved barrel domain protein
AhyD4_06670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_06690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_06700	COG2375	cellular response to nickel ion
AhyD4_06705	COG1538	Outer membrane efflux protein
AhyD4_06710	COG0577	efflux transmembrane transporter activity
AhyD4_06710	COG1136	(ABC) transporter
AhyD4_06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_06725	COG1227	inorganic diphosphatase activity
AhyD4_06735	COG0497	DNA recombination
AhyD4_06740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AhyD4_06745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AhyD4_06750	COG0443	Heat shock 70 kDa protein
AhyD4_06755	COG0484	heat shock protein binding
AhyD4_06785	COG1285	pathogenesis
AhyD4_06800	COG0640	Transcriptional regulator
AhyD4_06830	COG0095	Lipoate-protein ligase
AhyD4_06850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_06855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_06875	COG0708	Exodeoxyribonuclease III
AhyD4_06890	COG2211	Major facilitator Superfamily
AhyD4_06935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AhyD4_06940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AhyD4_06945	COG1845	cytochrome c oxidase, subunit III
AhyD4_06950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AhyD4_06955	COG0109	protoheme IX farnesyltransferase activity
AhyD4_06960	COG2814	Major facilitator Superfamily
AhyD4_06970	COG0784	Response regulator, receiver
AhyD4_06970	COG2205	protein histidine kinase activity
AhyD4_06970	COG2198	Histidine kinase
AhyD4_06975	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_06985	COG0745	RESPONSE REGULATOR receiver
AhyD4_07000	COG3381	protein complex oligomerization
AhyD4_07040	COG2003	Belongs to the UPF0758 family
AhyD4_07080	COG0583	DNA-binding transcription factor activity
AhyD4_07095	COG0549	Belongs to the carbamate kinase family
AhyD4_07100	COG1304	FMN binding
AhyD4_07105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AhyD4_07110	COG1335	isochorismatase
AhyD4_07125	COG3311	Transcriptional regulator
AhyD4_07145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_07175	COG0159	tryptophan synthase activity
AhyD4_07180	COG0133	tryptophan synthase activity
AhyD4_07185	COG0134	indole-3-glycerol-phosphate synthase activity
AhyD4_07185	COG0135	phosphoribosylanthranilate isomerase activity
AhyD4_07190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AhyD4_07195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AhyD4_07195	COG0512	Glutamine amidotransferase of anthranilate synthase
AhyD4_07200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AhyD4_07210	COG0009	L-threonylcarbamoyladenylate synthase
AhyD4_07220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AhyD4_07230	COG1946	Acyl-CoA thioesterase
AhyD4_07245	COG1309	transcriptional regulator
AhyD4_07250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_07255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_07265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AhyD4_07275	COG2244	polysaccharide biosynthetic process
AhyD4_07285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AhyD4_07290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_07295	COG0662	Cupin 2, conserved barrel domain protein
AhyD4_07295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AhyD4_07310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AhyD4_07315	COG1091	dTDP-4-dehydrorhamnose reductase activity
AhyD4_07320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AhyD4_07330	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AhyD4_07350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_07360	COG3132	Protein of unknown function, DUF480
AhyD4_07400	COG1278	Cold shock
AhyD4_07430	COG0697	spore germination
AhyD4_07435	COG1349	DNA-binding transcription factor activity
AhyD4_07445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_07450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AhyD4_07465	COG1187	pseudouridine synthase activity
AhyD4_07480	COG0622	Phosphoesterase
AhyD4_07495	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AhyD4_07500	COG0784	Response regulator, receiver
AhyD4_07500	COG0835	chemotaxis
AhyD4_07505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AhyD4_07510	COG1815	bacterial-type flagellum-dependent cell motility
AhyD4_07515	COG1558	bacterial-type flagellum-dependent cell motility
AhyD4_07530	COG4787	bacterial-type flagellum-dependent cell motility
AhyD4_07535	COG4786	Flagellar basal body rod
AhyD4_07540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AhyD4_07545	COG1706	bacterial-type flagellum-dependent cell motility
AhyD4_07550	COG1705	Flagellar rod assembly protein muramidase FlgJ
AhyD4_07550	COG3951	Flagellar rod assembly protein muramidase FlgJ
AhyD4_07555	COG1256	bacterial-type flagellum assembly
AhyD4_07565	COG2239	Acts as a magnesium transporter
AhyD4_07570	COG0248	Ppx GppA phosphatase
AhyD4_07575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AhyD4_07580	COG2716	regulation of RNA biosynthetic process
AhyD4_07590	COG2204	response regulator
AhyD4_07595	COG3852	Histidine kinase
AhyD4_07600	COG2204	response regulator
AhyD4_07605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AhyD4_07610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AhyD4_07615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AhyD4_07620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AhyD4_07640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AhyD4_07650	COG0590	tRNA wobble adenosine to inosine editing
AhyD4_07655	COG0573	inorganic phosphate transmembrane transporter activity
AhyD4_07660	COG0581	inorganic phosphate transmembrane transporter activity
AhyD4_07670	COG0704	Plays a role in the regulation of phosphate uptake
AhyD4_07675	COG1253	flavin adenine dinucleotide binding
AhyD4_07690	COG0531	amino acid
AhyD4_07705	COG1126	abc transporter atp-binding protein
AhyD4_07710	COG0765	amino acid transport
AhyD4_07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_07725	COG2271	Major facilitator Superfamily
AhyD4_07740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhyD4_07770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AhyD4_07775	COG0477	Major facilitator Superfamily
AhyD4_07780	COG0123	including yeast histone deacetylase and acetoin utilization protein
AhyD4_07790	COG1199	ATP-dependent helicase activity
AhyD4_07795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AhyD4_07805	COG1448	Aminotransferase
AhyD4_07810	COG0433	COG0433 Predicted ATPase
AhyD4_07880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_07890	COG1522	sequence-specific DNA binding
AhyD4_07920	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_07965	COG1663	tetraacyldisaccharide 4'-kinase activity
AhyD4_07970	COG2835	tetraacyldisaccharide 4'-kinase activity
AhyD4_07975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AhyD4_07980	COG2197	response regulator
AhyD4_07985	COG0322	excinuclease ABC activity
AhyD4_08010	COG0582	viral genome integration into host DNA
AhyD4_08035	COG4372	Transposase
AhyD4_08055	COG3962	Belongs to the TPP enzyme family
AhyD4_08060	COG0673	inositol 2-dehydrogenase activity
AhyD4_08065	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_08075	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_08080	COG0673	inositol 2-dehydrogenase activity
AhyD4_08085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_08095	COG3718	enzyme involved in inositol metabolism
AhyD4_08100	COG3039	Transposase
AhyD4_08105	COG2963	transposase activity
AhyD4_08110	COG2801	Transposase and inactivated derivatives
AhyD4_08175	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AhyD4_08180	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_08185	COG3301	Polysulphide reductase, NrfD
AhyD4_08190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_08200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AhyD4_08205	COG0215	cysteine-tRNA ligase activity
AhyD4_08220	COG2199	diguanylate cyclase activity
AhyD4_08220	COG2203	Gaf domain
AhyD4_08250	COG2119	membrane
AhyD4_08255	COG0023	Translation Initiation Factor
AhyD4_08280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_08295	COG2205	protein histidine kinase activity
AhyD4_08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_08305	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AhyD4_08315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_08320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AhyD4_08325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AhyD4_08330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AhyD4_08335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AhyD4_08340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AhyD4_08350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AhyD4_08355	COG0505	Belongs to the CarA family
AhyD4_08360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AhyD4_08365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AhyD4_08395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AhyD4_08400	COG0513	Belongs to the DEAD box helicase family
AhyD4_08410	COG4104	PAAR repeat-containing protein
AhyD4_08425	COG0789	Transcriptional regulator
AhyD4_08440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_08445	COG0765	amino acid transport
AhyD4_08455	COG0493	'glutamate synthase
AhyD4_08460	COG0069	glutamate synthase activity
AhyD4_08460	COG0067	glutamate synthase
AhyD4_08460	COG0070	glutamate synthase
AhyD4_08465	COG1242	4 iron, 4 sulfur cluster binding
AhyD4_08530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AhyD4_08535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AhyD4_08535	COG0574	Belongs to the PEP-utilizing enzyme family
AhyD4_08580	COG1464	Belongs to the NlpA lipoprotein family
AhyD4_08585	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_08590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AhyD4_08595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AhyD4_08605	COG0101	tRNA pseudouridine synthase activity
AhyD4_08610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AhyD4_08615	COG0285	dihydrofolate synthase activity
AhyD4_08620	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AhyD4_08625	COG2920	part of a sulfur-relay system
AhyD4_08630	COG1289	transmembrane transporter activity
AhyD4_08635	COG0670	Belongs to the BI1 family
AhyD4_08655	COG2194	sulfuric ester hydrolase activity
AhyD4_08665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AhyD4_08665	COG0392	lysyltransferase activity
AhyD4_08675	COG0840	transmembrane signaling receptor activity
AhyD4_08680	COG5001	Diguanylate cyclase
AhyD4_08685	COG0564	pseudouridine synthase activity
AhyD4_08700	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AhyD4_08710	COG0625	glutathione transferase activity
AhyD4_08715	COG0625	glutathione transferase activity
AhyD4_08725	COG0367	asparagine synthase
AhyD4_08735	COG4651	solute:proton antiporter activity
AhyD4_08735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhyD4_08740	COG0647	UMP catabolic process
AhyD4_08745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AhyD4_08750	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_08755	COG1253	flavin adenine dinucleotide binding
AhyD4_08765	COG0277	FAD linked oxidase domain protein
AhyD4_08765	COG0247	lactate metabolic process
AhyD4_08775	COG2050	protein possibly involved in aromatic compounds catabolism
AhyD4_08785	COG2056	Na+-H+ antiporter family
AhyD4_08790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhyD4_08805	COG0346	lactoylglutathione lyase activity
AhyD4_08810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AhyD4_08820	COG4659	FMN binding
AhyD4_08825	COG4658	electron transport chain
AhyD4_08835	COG2878	Part of a membrane complex involved in electron transport
AhyD4_08840	COG4657	Part of a membrane complex involved in electron transport
AhyD4_08845	COG0697	spore germination
AhyD4_08860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AhyD4_08865	COG1288	antiporter activity
AhyD4_08870	COG0436	Aminotransferase
AhyD4_08880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AhyD4_08885	COG2027	D-alanyl-D-alanine carboxypeptidase
AhyD4_08890	COG1061	Type III restriction enzyme res subunit
AhyD4_08895	COG1566	PFAM secretion protein HlyD family protein
AhyD4_08905	COG1966	Carbon starvation protein
AhyD4_08910	COG3279	Response regulator of the LytR AlgR family
AhyD4_08915	COG3275	phosphorelay sensor kinase activity
AhyD4_08920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_08920	COG2199	diguanylate cyclase activity
AhyD4_08925	COG1454	alcohol dehydrogenase
AhyD4_08925	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_08935	COG2095	MarC family integral membrane protein
AhyD4_08945	COG0601	transmembrane transport
AhyD4_08950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_08955	COG0444	Belongs to the ABC transporter superfamily
AhyD4_08970	COG0861	Integral membrane protein TerC family
AhyD4_08975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_08985	COG1301	dicarboxylic acid transport
AhyD4_09000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AhyD4_09015	COG0537	adenosine 5'-monophosphoramidase activity
AhyD4_09050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_09055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_09065	COG2354	Protein conserved in bacteria
AhyD4_09080	COG2233	PERMEase
AhyD4_09090	COG1252	NADH dehydrogenase
AhyD4_09110	COG0393	Putative heavy-metal-binding
AhyD4_09120	COG1648	precorrin-2 dehydrogenase activity
AhyD4_09120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_09125	COG2221	Nitrite and sulphite reductase 4Fe-4S
AhyD4_09140	COG4667	esterase of the alpha-beta hydrolase superfamily
AhyD4_09145	COG1619	proteins homologs of microcin C7 resistance protein MccF
AhyD4_09150	COG1368	sulfuric ester hydrolase activity
AhyD4_09160	COG0527	aspartate kinase activity
AhyD4_09165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AhyD4_09165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AhyD4_09170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AhyD4_09195	COG0596	Alpha beta hydrolase
AhyD4_09200	COG0346	lactoylglutathione lyase activity
AhyD4_09210	COG0583	DNA-binding transcription factor activity
AhyD4_09215	COG1620	l-lactate permease
AhyD4_09225	COG1139	Iron-sulfur cluster binding protein
AhyD4_09250	COG1136	(ABC) transporter
AhyD4_09260	COG2814	Major facilitator Superfamily
AhyD4_09280	COG0672	)-iron permease
AhyD4_09310	COG0659	secondary active sulfate transmembrane transporter activity
AhyD4_09355	COG2963	transposase activity
AhyD4_09380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_09385	COG0840	transmembrane signaling receptor activity
AhyD4_09395	COG2201	protein-glutamate methylesterase activity
AhyD4_09405	COG0835	chemotaxis
AhyD4_09410	COG3290	protein histidine kinase activity
AhyD4_09410	COG0840	transmembrane signaling receptor activity
AhyD4_09415	COG0643	Histidine kinase
AhyD4_09415	COG2198	Histidine kinase
AhyD4_09425	COG0745	RESPONSE REGULATOR receiver
AhyD4_09430	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AhyD4_09435	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_09440	COG5557	Pfam Polysulphide reductase, NrfD
AhyD4_09445	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AhyD4_09450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AhyD4_09455	COG1773	rubredoxin
AhyD4_09460	COG0747	negative chemotaxis
AhyD4_09465	COG0601	transmembrane transport
AhyD4_09470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_09475	COG0444	Belongs to the ABC transporter superfamily
AhyD4_09480	COG3842	ATPase activity
AhyD4_09485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AhyD4_09490	COG0375	protein maturation
AhyD4_09495	COG0309	Hydrogenase expression formation protein (HypE)
AhyD4_09505	COG0298	carbon dioxide binding
AhyD4_09510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AhyD4_09520	COG1921	L-seryl-tRNASec selenium transferase activity
AhyD4_09525	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AhyD4_09535	COG3260	NADH ubiquinone oxidoreductase 20
AhyD4_09540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_09545	COG3261	NADH dehydrogenase
AhyD4_09545	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AhyD4_09550	COG0650	Formate hydrogenlyase subunit 4
AhyD4_09555	COG0651	ATP synthesis coupled electron transport
AhyD4_09560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_09565	COG3158	transport of potassium into the cell
AhyD4_09570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_09575	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_09580	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_09600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AhyD4_09605	COG0326	Molecular chaperone. Has ATPase activity
AhyD4_09610	COG0563	adenylate kinase activity
AhyD4_09615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AhyD4_09625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_09645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_09665	COG1021	2,3-dihydroxybenzoate-AMP ligase
AhyD4_09670	COG1535	isochorismatase
AhyD4_09670	COG3433	isochorismatase activity
AhyD4_09675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AhyD4_09680	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_09690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AhyD4_09695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AhyD4_09700	COG2977	Belongs to the P-Pant transferase superfamily
AhyD4_09705	COG1120	ATPase activity
AhyD4_09710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_09715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_09720	COG4771	TonB-dependent receptor
AhyD4_09740	COG0598	Magnesium transport protein CorA
AhyD4_09760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AhyD4_09765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AhyD4_09770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_09785	COG1570	exodeoxyribonuclease VII activity
AhyD4_09790	COG0697	spore germination
AhyD4_09810	COG3158	transport of potassium into the cell
AhyD4_09815	COG0517	IMP dehydrogenase activity
AhyD4_09815	COG0516	GMP reductase activity
AhyD4_09820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AhyD4_09820	COG0519	Catalyzes the synthesis of GMP from XMP
AhyD4_09825	COG0582	viral genome integration into host DNA
AhyD4_09875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AhyD4_09875	COG2169	Transcriptional regulator
AhyD4_09900	COG2062	phosphohistidine phosphatase, SixA
AhyD4_09910	COG0697	spore germination
AhyD4_09915	COG4166	transmembrane transport
AhyD4_09920	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AhyD4_09925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AhyD4_09935	COG4591	ABC-type transport system involved in lipoprotein release permease component
AhyD4_09940	COG1136	(ABC) transporter
AhyD4_09945	COG4591	ABC-type transport system involved in lipoprotein release permease component
AhyD4_09950	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AhyD4_09960	COG0544	peptidyl-prolyl cis-trans isomerase activity
AhyD4_09965	COG0740	serine-type endopeptidase activity
AhyD4_09970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AhyD4_09975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AhyD4_09985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhyD4_09990	COG0488	(ABC) transporter
AhyD4_09995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_10000	COG3162	membrane
AhyD4_10015	COG1024	Enoyl-CoA hydratase
AhyD4_10050	COG1115	amino acid carrier protein
AhyD4_10065	COG1584	GPR1 FUN34 yaaH family protein
AhyD4_10100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AhyD4_10105	COG1960	acyl-CoA dehydrogenase activity
AhyD4_10115	COG1960	acyl-CoA dehydrogenase activity
AhyD4_10120	COG1024	Enoyl-CoA hydratase
AhyD4_10125	COG1024	Enoyl-CoA hydratase
AhyD4_10135	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_10145	COG0730	response to heat
AhyD4_10180	COG2003	Belongs to the UPF0758 family
AhyD4_10190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AhyD4_10210	COG1073	alpha beta
AhyD4_10215	COG0823	Involved in the tonB-independent uptake of proteins
AhyD4_10215	COG1506	peptidase
AhyD4_10220	COG0702	epimerase
AhyD4_10225	COG0583	DNA-binding transcription factor activity
AhyD4_10230	COG0667	Aldo Keto reductase
AhyD4_10245	COG3706	GGDEF domain
AhyD4_10250	COG0583	DNA-binding transcription factor activity
AhyD4_10255	COG2723	6-phospho-beta-galactosidase activity
AhyD4_10260	COG3300	MHYT domain
AhyD4_10260	COG5001	Diguanylate cyclase
AhyD4_10270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_10275	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_10280	COG0583	DNA-binding transcription factor activity
AhyD4_10285	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AhyD4_10290	COG0673	inositol 2-dehydrogenase activity
AhyD4_10295	COG0583	DNA-binding transcription factor activity
AhyD4_10305	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_10310	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_10335	COG0417	DNA replication proofreading
AhyD4_10365	COG0534	Mate efflux family protein
AhyD4_10375	COG0307	riboflavin synthase, alpha
AhyD4_10385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_10390	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AhyD4_10395	COG0697	spore germination
AhyD4_10400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AhyD4_10440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AhyD4_10450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AhyD4_10455	COG2894	cell division
AhyD4_10460	COG0850	regulation of cytokinetic process
AhyD4_10465	COG3100	YcgL domain-containing protein
AhyD4_10470	COG2951	lytic endotransglycosylase activity
AhyD4_10475	COG1760	l-serine dehydratase
AhyD4_10480	COG1760	l-serine dehydratase
AhyD4_10485	COG3123	guanosine phosphorylase activity
AhyD4_10505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AhyD4_10525	COG1595	DNA-templated transcription, initiation
AhyD4_10555	COG0714	Associated with various cellular activities
AhyD4_10560	COG0183	Belongs to the thiolase family
AhyD4_10565	COG1024	Enoyl-CoA hydratase
AhyD4_10565	COG1250	3-hydroxyacyl-CoA dehydrogenase
AhyD4_10570	COG4681	YaeQ
AhyD4_10590	COG4388	Caudovirus prohead serine protease
AhyD4_10600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AhyD4_10605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AhyD4_10610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AhyD4_10620	COG0549	Belongs to the carbamate kinase family
AhyD4_10625	COG0697	spore germination
AhyD4_10630	COG3608	succinylglutamate desuccinylase aspartoacylase
AhyD4_10630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AhyD4_10635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AhyD4_10645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_10645	COG0493	'glutamate synthase
AhyD4_10650	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_10655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AhyD4_10660	COG2080	2 iron, 2 sulfur cluster binding
AhyD4_10660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AhyD4_10665	COG2233	PERMEase
AhyD4_10670	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_10675	COG2252	PERMEase
AhyD4_10680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AhyD4_10685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AhyD4_10690	COG2080	2 iron, 2 sulfur cluster binding
AhyD4_10700	COG3134	Outer membrane lipoprotein
AhyD4_10710	COG1288	antiporter activity
AhyD4_10715	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_10720	COG0140	phosphoribosyl-ATP diphosphatase activity
AhyD4_10720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AhyD4_10725	COG0107	imidazoleglycerol-phosphate synthase activity
AhyD4_10730	COG2205	protein histidine kinase activity
AhyD4_10730	COG0784	Response regulator, receiver
AhyD4_10730	COG2198	Histidine kinase
AhyD4_10740	COG3437	response regulator, receiver
AhyD4_10745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AhyD4_10750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AhyD4_10755	COG0131	Imidazoleglycerol-phosphate dehydratase
AhyD4_10755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AhyD4_10760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AhyD4_10765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AhyD4_10770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AhyD4_10780	COG1199	ATP-dependent helicase activity
AhyD4_10785	COG1214	PFAM Peptidase M22, glycoprotease
AhyD4_10795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AhyD4_10795	COG2226	methyltransferase
AhyD4_10795	COG0596	Alpha beta hydrolase
AhyD4_10800	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_10805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AhyD4_10925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AhyD4_10935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AhyD4_10940	COG2832	Protein of unknown function (DUF454)
AhyD4_10945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AhyD4_10955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AhyD4_10960	COG0582	viral genome integration into host DNA
AhyD4_10990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhyD4_11090	COG0753	catalase activity
AhyD4_11115	COG3646	Phage regulatory protein
AhyD4_11115	COG3645	SOS response
AhyD4_11140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhyD4_11145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhyD4_11160	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_11320	COG1643	Atp-dependent helicase
AhyD4_11330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AhyD4_11340	COG3437	response regulator, receiver
AhyD4_11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AhyD4_11350	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AhyD4_11355	COG0709	Synthesizes selenophosphate from selenide and ATP
AhyD4_11375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AhyD4_11380	COG0840	transmembrane signaling receptor activity
AhyD4_11385	COG1254	Belongs to the acylphosphatase family
AhyD4_11390	COG0625	glutathione transferase activity
AhyD4_11395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_11395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_11400	COG0489	protein tyrosine kinase activity
AhyD4_11405	COG0572	uridine kinase
AhyD4_11410	COG0717	Belongs to the dCTP deaminase family
AhyD4_11415	COG0306	phosphate transporter
AhyD4_11420	COG1530	ribonuclease E activity
AhyD4_11425	COG0564	pseudouridine synthase activity
AhyD4_11435	COG0424	maF-like protein
AhyD4_11440	COG2814	Major facilitator Superfamily
AhyD4_11455	COG1399	metal-binding, possibly nucleic acid-binding protein
AhyD4_11460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AhyD4_11465	COG0416	fatty acid biosynthetic process
AhyD4_11470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AhyD4_11480	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_11485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_11490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AhyD4_11495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AhyD4_11500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AhyD4_11505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AhyD4_11510	COG0470	DNA polymerase III
AhyD4_11515	COG0084	hydrolase, TatD family'
AhyD4_11530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AhyD4_11530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_11535	COG3008	intermembrane lipid transfer
AhyD4_11540	COG2995	paraquat-inducible protein a
AhyD4_11550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AhyD4_11555	COG0372	Belongs to the citrate synthase family
AhyD4_11600	COG4221	oxidoreductase activity
AhyD4_11610	COG3141	response to X-ray
AhyD4_11620	COG1067	ATP-dependent peptidase activity
AhyD4_11625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AhyD4_11635	COG0488	(ABC) transporter
AhyD4_11645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AhyD4_11645	COG0116	Belongs to the methyltransferase superfamily
AhyD4_11655	COG0167	dihydroorotate dehydrogenase activity
AhyD4_11660	COG2902	Dehydrogenase
AhyD4_11670	COG0308	aminopeptidase N
AhyD4_11680	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AhyD4_11685	COG1956	GAF domain-containing protein
AhyD4_11695	COG3278	Belongs to the heme-copper respiratory oxidase family
AhyD4_11710	COG2010	Cytochrome c
AhyD4_11735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhyD4_11740	COG0589	response to stress
AhyD4_11745	COG0037	tRNA processing
AhyD4_11760	COG0625	glutathione transferase activity
AhyD4_11765	COG1869	D-ribose catabolic process
AhyD4_11770	COG1129	ABC transporter
AhyD4_11775	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_11780	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_11785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_11790	COG1609	Transcriptional regulator
AhyD4_11805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AhyD4_11825	COG0776	regulation of translation
AhyD4_11830	COG0072	phenylalanine-tRNA ligase activity
AhyD4_11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_11835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AhyD4_11840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AhyD4_11845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AhyD4_11850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AhyD4_11855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AhyD4_11875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AhyD4_11885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_11890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_11895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_11900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AhyD4_11905	COG3313	Fe-S protein
AhyD4_11910	COG2942	2-epimerase
AhyD4_11915	COG3716	PTS system mannose fructose sorbose family IID component
AhyD4_11920	COG3715	PTS system
AhyD4_11925	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_11925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_11940	COG1609	Transcriptional regulator
AhyD4_11945	COG2140	Oxalate decarboxylase
AhyD4_11950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AhyD4_11950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_11950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_11955	COG1105	Belongs to the carbohydrate kinase PfkB family
AhyD4_11960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_11960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_11965	COG1609	Transcriptional regulator
AhyD4_11970	COG0814	amino acid
AhyD4_11980	COG5654	RES domain protein
AhyD4_11990	COG0513	Belongs to the DEAD box helicase family
AhyD4_12000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AhyD4_12005	COG2890	protein-(glutamine-N5) methyltransferase activity
AhyD4_12010	COG2840	Smr protein MutS2
AhyD4_12020	COG3706	GGDEF domain
AhyD4_12025	COG0588	phosphoglycerate mutase activity
AhyD4_12050	COG2824	Alkylphosphonate utilization operon protein PhnA
AhyD4_12065	COG0384	phenazine biosynthesis protein PhzF
AhyD4_12080	COG0242	peptide deformylase activity
AhyD4_12100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AhyD4_12105	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AhyD4_12115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AhyD4_12120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AhyD4_12130	COG0205	6-phosphofructokinase activity
AhyD4_12135	COG1473	amidohydrolase
AhyD4_12140	COG1011	Hydrolase
AhyD4_12145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_12195	COG3593	DNA synthesis involved in DNA repair
AhyD4_12210	COG0583	DNA-binding transcription factor activity
AhyD4_12215	COG0730	response to heat
AhyD4_12230	COG1181	Belongs to the D-alanine--D-alanine ligase family
AhyD4_12240	COG0386	Belongs to the glutathione peroxidase family
AhyD4_12245	COG0513	Belongs to the DEAD box helicase family
AhyD4_12250	COG0456	acetyltransferase
AhyD4_12260	COG1742	UPF0060 membrane protein
AhyD4_12290	COG2329	Antibiotic biosynthesis monooxygenase
AhyD4_12295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AhyD4_12315	COG3243	poly(R)-hydroxyalkanoic acid synthase
AhyD4_12325	COG2501	S4 domain
AhyD4_12335	COG1132	(ABC) transporter
AhyD4_12340	COG1132	(ABC) transporter
AhyD4_12350	COG3118	belongs to the thioredoxin family
AhyD4_12360	COG0058	SHG alpha-glucan phosphorylase activity
AhyD4_12390	COG0814	amino acid
AhyD4_12395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AhyD4_12400	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_12405	COG2766	serine protein kinase
AhyD4_12415	COG2719	SpoVR family
AhyD4_12420	COG2186	Transcriptional regulator
AhyD4_12425	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_12430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AhyD4_12435	COG0586	Pfam SNARE associated Golgi protein
AhyD4_12445	COG0556	nucleotide-excision repair
AhyD4_12455	COG2985	domain, Protein
AhyD4_12455	COG0569	domain protein
AhyD4_12460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AhyD4_12480	COG4565	transcriptional regulatory protein
AhyD4_12485	COG3290	protein histidine kinase activity
AhyD4_12490	COG1846	Transcriptional regulator
AhyD4_12490	COG1940	carbohydrate kinase activity
AhyD4_12495	COG0840	transmembrane signaling receptor activity
AhyD4_12500	COG3012	SEC-C Motif Domain Protein
AhyD4_12505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AhyD4_12510	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AhyD4_12515	COG0247	lactate metabolic process
AhyD4_12535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AhyD4_12540	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_12545	COG3301	Polysulphide reductase, NrfD
AhyD4_12550	COG1138	Cytochrome C-type biogenesis protein
AhyD4_12560	COG3088	subunit of a heme lyase
AhyD4_12560	COG4235	cytochrome complex assembly
AhyD4_12565	COG1051	belongs to the nudix hydrolase family
AhyD4_12575	COG3033	Beta-eliminating lyase
AhyD4_12580	COG3046	protein related to deoxyribodipyrimidine photolyase
AhyD4_12585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_12610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AhyD4_12615	COG0583	DNA-binding transcription factor activity
AhyD4_12625	COG4774	siderophore transport
AhyD4_12630	COG4977	sequence-specific DNA binding
AhyD4_12640	COG0583	DNA-binding transcription factor activity
AhyD4_12645	COG2910	NAD(P)H-binding
AhyD4_12655	COG0626	cystathionine gamma-synthase activity
AhyD4_12660	COG0612	Peptidase, M16
AhyD4_12665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AhyD4_12670	COG2076	Multidrug Resistance protein
AhyD4_12675	COG1944	ATP diphosphatase activity
AhyD4_12680	COG2116	formate transmembrane transporter activity
AhyD4_12685	COG1882	Formate acetyltransferase
AhyD4_12690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_12700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AhyD4_12710	COG1840	ABC-type Fe3 transport system, periplasmic component
AhyD4_12715	COG3842	ATPase activity
AhyD4_12725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_12730	COG2983	Belongs to the UPF0260 family
AhyD4_12740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AhyD4_12745	COG0045	succinate-CoA ligase (ADP-forming) activity
AhyD4_12750	COG0508	dehydrogenase complex catalyzes the overall conversion of
AhyD4_12755	COG0567	Dehydrogenase, E1 component
AhyD4_12765	COG1053	succinate dehydrogenase
AhyD4_12770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AhyD4_12775	COG2009	succinate dehydrogenase
AhyD4_12795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AhyD4_12800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AhyD4_12800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_12810	COG3069	C4-dicarboxylate transmembrane transporter activity
AhyD4_12825	COG1451	nucleotide metabolic process
AhyD4_12840	COG0254	rRNA binding
AhyD4_12845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AhyD4_12855	COG0583	DNA-binding transcription factor activity
AhyD4_12865	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_12875	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_12880	COG1069	ribulokinase activity
AhyD4_12890	COG2160	L-arabinose isomerase activity
AhyD4_12895	COG2925	Exonuclease
AhyD4_12905	COG3345	alpha-galactosidase
AhyD4_12910	COG1380	Effector of murein hydrolase LrgA
AhyD4_12915	COG1346	cytolysis
AhyD4_12920	COG0295	cytidine deaminase activity
AhyD4_12925	COG1022	Amp-dependent synthetase and ligase
AhyD4_12940	COG0861	Integral membrane protein TerC family
AhyD4_12945	COG2885	chlorophyll binding
AhyD4_12950	COG2199	diguanylate cyclase activity
AhyD4_12965	COG2154	pterin-4-alpha-carbinolamine dehydratase
AhyD4_12970	COG2154	pterin-4-alpha-carbinolamine dehydratase
AhyD4_12980	COG3768	UPF0283 membrane protein
AhyD4_12985	COG3106	COG3106 Predicted ATPase
AhyD4_13000	COG1842	Phage shock protein A
AhyD4_13005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AhyD4_13015	COG4168	peptide transport system, permease
AhyD4_13020	COG4171	peptide transport system, permease
AhyD4_13030	COG4172	Belongs to the ABC transporter superfamily
AhyD4_13040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AhyD4_13045	COG1286	toxin biosynthetic process
AhyD4_13050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AhyD4_13060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AhyD4_13065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AhyD4_13070	COG1674	ftsk spoiiie
AhyD4_13070	COG0531	amino acid
AhyD4_13080	COG0492	ferredoxin-NADP+ reductase activity
AhyD4_13085	COG3706	GGDEF domain
AhyD4_13090	COG3134	Outer membrane lipoprotein
AhyD4_13095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AhyD4_13100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AhyD4_13105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AhyD4_13110	COG0542	response to heat
AhyD4_13115	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AhyD4_13120	COG1278	Cold shock
AhyD4_13125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AhyD4_13155	COG3179	chitinase
AhyD4_13165	COG3501	Rhs element vgr protein
AhyD4_13270	COG3501	Rhs element vgr protein
AhyD4_13300	COG1435	thymidine kinase activity
AhyD4_13305	COG1757	Na H antiporter
AhyD4_13310	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_13315	COG2096	Adenosyltransferase
AhyD4_13320	COG3530	Putative quorum-sensing-regulated virulence factor
AhyD4_13325	COG0602	queuosine metabolic process
AhyD4_13330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AhyD4_13350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AhyD4_13360	COG0776	regulation of translation
AhyD4_13365	COG0539	negative regulation of cytoplasmic translation
AhyD4_13370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AhyD4_13375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AhyD4_13385	COG0583	DNA-binding transcription factor activity
AhyD4_13405	COG0778	Nitroreductase
AhyD4_13410	COG3300	MHYT domain
AhyD4_13410	COG5001	Diguanylate cyclase
AhyD4_13420	COG0583	DNA-binding transcription factor activity
AhyD4_13425	COG3437	response regulator, receiver
AhyD4_13450	COG4989	oxidoreductase activity
AhyD4_13455	COG0724	RNA recognition motif
AhyD4_13475	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AhyD4_13490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_13495	COG1360	Flagellar Motor Protein
AhyD4_13500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_13505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_13510	COG0649	NAD binding
AhyD4_13510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_13525	COG1034	ATP synthesis coupled electron transport
AhyD4_13530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AhyD4_13535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_13540	COG0839	Belongs to the complex I subunit 6 family
AhyD4_13545	COG0713	ATP synthesis coupled electron transport
AhyD4_13555	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_13560	COG1007	ATP synthesis coupled electron transport
AhyD4_13570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AhyD4_13570	COG0047	phosphoribosylformylglycinamidine synthase activity
AhyD4_13575	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AhyD4_13580	COG1645	bacterial-type flagellum-dependent swarming motility
AhyD4_13585	COG1160	GTP binding
AhyD4_13590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_13595	COG2976	Protein conserved in bacteria
AhyD4_13600	COG0124	histidyl-tRNA synthetase
AhyD4_13605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AhyD4_13620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AhyD4_13625	COG0105	UTP biosynthetic process
AhyD4_13630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_13640	COG0633	Ferredoxin
AhyD4_13645	COG0443	Heat shock 70 kDa protein
AhyD4_13650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AhyD4_13660	COG0822	iron-sulfur transferase activity
AhyD4_13665	COG1104	cysteine desulfurase activity
AhyD4_13710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_13715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_13720	COG1862	Preprotein translocase
AhyD4_13725	COG0343	queuine tRNA-ribosyltransferase activity
AhyD4_13730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AhyD4_13735	COG0517	IMP dehydrogenase activity
AhyD4_13740	COG0450	alkyl hydroperoxide reductase
AhyD4_13745	COG3634	alkyl hydroperoxide reductase activity
AhyD4_13750	COG2814	Major facilitator Superfamily
AhyD4_13765	COG1393	Belongs to the ArsC family
AhyD4_13770	COG0798	PFAM Bile acid sodium symporter
AhyD4_13775	COG0640	Transcriptional regulator
AhyD4_13780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AhyD4_13780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AhyD4_13785	COG0509	glycine decarboxylation via glycine cleavage system
AhyD4_13790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AhyD4_13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_13820	COG2814	Major facilitator Superfamily
AhyD4_13825	COG0625	glutathione transferase activity
AhyD4_13835	COG0483	inositol monophosphate 1-phosphatase activity
AhyD4_13855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AhyD4_13870	COG1086	Polysaccharide biosynthesis protein
AhyD4_13890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AhyD4_13905	COG2089	acid synthase
AhyD4_13975	COG0301	tRNA thio-modification
AhyD4_13975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_13985	COG4953	penicillin-binding protein 1C
AhyD4_13990	COG2373	Large extracellular alpha-helical protein
AhyD4_13995	COG1473	amidohydrolase
AhyD4_14000	COG0628	permease
AhyD4_14005	COG1538	Outer membrane efflux protein
AhyD4_14010	COG1566	PFAM secretion protein HlyD family protein
AhyD4_14025	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_14035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_14050	COG4215	(ABC) transporter
AhyD4_14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_14065	COG2431	L-lysine efflux transmembrane transporter activity
AhyD4_14070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_14075	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AhyD4_14090	COG1393	Belongs to the ArsC family
AhyD4_14100	COG4783	chaperone-mediated protein folding
AhyD4_14105	COG0425	Belongs to the sulfur carrier protein TusA family
AhyD4_14130	COG3842	ATPase activity
AhyD4_14140	COG1175	transmembrane transport
AhyD4_14150	COG3081	Nucleoid-associated protein
AhyD4_14155	COG3082	Protein of unknown function (DUF1414)
AhyD4_14160	COG3083	sulfuric ester hydrolase activity
AhyD4_14165	COG4771	TonB-dependent receptor
AhyD4_14170	COG1770	oligopeptidase
AhyD4_14190	COG4574	serine-type endopeptidase inhibitor activity
AhyD4_14195	COG3085	chromosome segregation
AhyD4_14200	COG0583	DNA-binding transcription factor activity
AhyD4_14205	COG0287	Prephenate dehydrogenase
AhyD4_14205	COG1605	Chorismate mutase
AhyD4_14210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_14215	COG0584	glycerophosphoryl diester phosphodiesterase
AhyD4_14225	COG1349	DNA-binding transcription factor activity
AhyD4_14230	COG2271	Major facilitator Superfamily
AhyD4_14235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AhyD4_14240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AhyD4_14245	COG0583	DNA-binding transcription factor activity
AhyD4_14265	COG0656	L-ascorbic acid biosynthetic process
AhyD4_14270	COG2814	Major facilitator Superfamily
AhyD4_14280	COG1294	oxidase, subunit
AhyD4_14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_14300	COG2979	Protein of unknown function (DUF533)
AhyD4_14320	COG2271	Major facilitator Superfamily
AhyD4_14325	COG0583	DNA-binding transcription factor activity
AhyD4_14335	COG2807	transmembrane transport
AhyD4_14340	COG1187	pseudouridine synthase activity
AhyD4_14365	COG1061	Type III restriction enzyme res subunit
AhyD4_14375	COG2964	Protein conserved in bacteria
AhyD4_14380	COG3681	Belongs to the UPF0597 family
AhyD4_14390	COG0814	amino acid
AhyD4_14410	COG1166	arginine decarboxylase activity
AhyD4_14415	COG2195	Cleaves the N-terminal amino acid of tripeptides
AhyD4_14445	COG0583	DNA-binding transcription factor activity
AhyD4_14455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AhyD4_14460	COG0840	transmembrane signaling receptor activity
AhyD4_14465	COG0302	gtp cyclohydrolase
AhyD4_14475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AhyD4_14480	COG2267	carboxylic ester hydrolase activity
AhyD4_14485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AhyD4_14500	COG0314	molybdopterin synthase activity
AhyD4_14505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AhyD4_14510	COG0315	cyclic pyranopterin monophosphate synthase activity
AhyD4_14515	COG0521	Mo-molybdopterin cofactor biosynthetic process
AhyD4_14520	COG3005	denitrification pathway
AhyD4_14530	COG0348	domain, Protein
AhyD4_14535	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_14540	COG0243	molybdopterin cofactor binding
AhyD4_14550	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_14550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_14555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AhyD4_14560	COG3850	Histidine kinase
AhyD4_14565	COG2197	response regulator
AhyD4_14595	COG0121	glutamine amidotransferase
AhyD4_14600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AhyD4_14605	COG1960	acyl-CoA dehydrogenase activity
AhyD4_14610	COG3437	response regulator, receiver
AhyD4_14610	COG0784	Response regulator, receiver
AhyD4_14620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhyD4_14625	COG0328	RNA-DNA hybrid ribonuclease activity
AhyD4_14630	COG2226	methyltransferase
AhyD4_14635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AhyD4_14640	COG0741	lytic transglycosylase activity
AhyD4_14640	COG1388	LysM domain
AhyD4_14645	COG3021	interspecies interaction between organisms
AhyD4_14655	COG1607	acyl-coa hydrolase
AhyD4_14670	COG0741	lytic transglycosylase activity
AhyD4_14680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AhyD4_14705	COG0729	surface antigen
AhyD4_14715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhyD4_14720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AhyD4_14730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AhyD4_14740	COG4134	Bacterial extracellular solute-binding protein
AhyD4_14750	COG4136	ATPase activity
AhyD4_14755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AhyD4_14760	COG2951	lytic endotransglycosylase activity
AhyD4_14765	COG1846	Transcriptional regulator
AhyD4_14775	COG0033	Phosphoglucomutase
AhyD4_14780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AhyD4_14785	COG0596	Alpha beta hydrolase
AhyD4_14800	COG0716	FMN binding
AhyD4_14810	COG0735	belongs to the Fur family
AhyD4_14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_14825	COG1263	PTS System
AhyD4_14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_14825	COG2190	(PTS) system
AhyD4_14830	COG0363	glucosamine-6-phosphate deaminase activity
AhyD4_14835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_14840	COG1940	carbohydrate kinase activity
AhyD4_14840	COG1846	Transcriptional regulator
AhyD4_14845	COG2194	sulfuric ester hydrolase activity
AhyD4_14850	COG0217	transcriptional regulatory protein
AhyD4_14855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AhyD4_14860	COG1801	Protein of unknown function DUF72
AhyD4_14865	COG4106	trans-aconitate 2-methyltransferase activity
AhyD4_14870	COG0500	methyltransferase
AhyD4_14890	COG0450	alkyl hydroperoxide reductase
AhyD4_14895	COG0583	DNA-binding transcription factor activity
AhyD4_14905	COG0791	NLP P60 protein
AhyD4_14920	COG1309	transcriptional regulator
AhyD4_14960	COG0534	Mate efflux family protein
AhyD4_14980	COG2366	antibiotic biosynthetic process
AhyD4_14985	COG0674	pyruvate-flavodoxin oxidoreductase activity
AhyD4_14985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AhyD4_14985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AhyD4_14985	COG1013	pyruvate-flavodoxin oxidoreductase activity
AhyD4_14995	COG0633	Ferredoxin
AhyD4_14995	COG3217	Mosc domain protein beta barrel domain protein
AhyD4_14995	COG0633	Ferredoxin
AhyD4_14995	COG3217	Mosc domain protein beta barrel domain protein
AhyD4_15005	COG0501	Belongs to the peptidase M48B family
AhyD4_15010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AhyD4_15015	COG2226	methyltransferase
AhyD4_15015	COG1073	alpha beta
AhyD4_15020	COG0156	8-amino-7-oxononanoate synthase activity
AhyD4_15025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AhyD4_15045	COG0017	Asparaginyl-tRNA synthetase
AhyD4_15050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AhyD4_15065	COG3069	C4-dicarboxylate transmembrane transporter activity
AhyD4_15075	COG0583	DNA-binding transcription factor activity
AhyD4_15080	COG1393	Belongs to the ArsC family
AhyD4_15085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AhyD4_15090	COG1876	peptidase activity
AhyD4_15095	COG3263	regulation of cellular component size
AhyD4_15115	COG1280	lysine exporter protein (LysE YggA)
AhyD4_15140	COG1957	nucleoside hydrolase
AhyD4_15145	COG0564	pseudouridine synthase activity
AhyD4_15155	COG1454	alcohol dehydrogenase
AhyD4_15205	COG4964	Belongs to the GSP D family
AhyD4_15235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_15240	COG0702	epimerase
AhyD4_15250	COG2867	negative regulation of translational initiation
AhyD4_15255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AhyD4_15345	COG4397	Mu-like prophage major head subunit gpT
AhyD4_15350	COG4388	Caudovirus prohead serine protease
AhyD4_15370	COG4383	Mu-like prophage protein gp29
AhyD4_15375	COG4373	Mu-like prophage FluMu protein gp28
AhyD4_15385	COG0640	Transcriptional regulator
AhyD4_15420	COG5566	PFAM Mor transcription activator
AhyD4_15530	COG0583	DNA-binding transcription factor activity
AhyD4_15535	COG2610	gluconate transmembrane transporter activity
AhyD4_15540	COG3048	D-serine ammonia-lyase activity
AhyD4_15545	COG0538	isocitrate dehydrogenase activity
AhyD4_15550	COG2207	Transcriptional regulator
AhyD4_15565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_15575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AhyD4_15580	COG1263	PTS System
AhyD4_15580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_15585	COG1609	Transcriptional regulator
AhyD4_15600	COG0456	acetyltransferase
AhyD4_15620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_15620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_15620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_15630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_15640	COG1187	pseudouridine synthase activity
AhyD4_15650	COG0482	sulfurtransferase activity
AhyD4_15655	COG2915	High frequency lysogenization protein hflD homolog
AhyD4_15660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AhyD4_15665	COG2850	peptidyl-arginine hydroxylation
AhyD4_15675	COG3153	acetyltransferase
AhyD4_15685	COG0625	glutathione transferase activity
AhyD4_15690	COG0259	pyridoxamine-phosphate oxidase activity
AhyD4_15705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_15705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_15710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AhyD4_15725	COG4235	cytochrome complex assembly
AhyD4_15725	COG3088	subunit of a heme lyase
AhyD4_15730	COG4235	cytochrome complex assembly
AhyD4_15730	COG3088	subunit of a heme lyase
AhyD4_15735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AhyD4_15740	COG1138	Cytochrome C-type biogenesis protein
AhyD4_15745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AhyD4_15750	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_15755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_15760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_15775	COG0835	chemotaxis
AhyD4_15785	COG1192	Involved in chromosome partitioning
AhyD4_15790	COG1360	Flagellar Motor Protein
AhyD4_15795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_15800	COG2201	protein-glutamate methylesterase activity
AhyD4_15805	COG2198	Histidine kinase
AhyD4_15805	COG0643	Histidine kinase
AhyD4_15810	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AhyD4_15825	COG0455	bacterial-type flagellum organization
AhyD4_15835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AhyD4_15845	COG1684	flagellar biosynthetic protein fliR
AhyD4_15850	COG1987	bacterial-type flagellum assembly
AhyD4_15900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AhyD4_15910	COG1677	Flagellar hook-basal body complex protein FliE
AhyD4_15925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AhyD4_15935	COG3064	Membrane
AhyD4_15935	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AhyD4_15935	COG1073	alpha beta
AhyD4_15950	COG2274	protein secretion by the type I secretion system
AhyD4_15960	COG2274	protein secretion by the type I secretion system
AhyD4_15965	COG0745	RESPONSE REGULATOR receiver
AhyD4_15980	COG1737	Transcriptional regulator
AhyD4_15985	COG0469	pyruvate kinase activity
AhyD4_15995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_16000	COG1960	acyl-CoA dehydrogenase activity
AhyD4_16010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AhyD4_16020	COG0243	molybdopterin cofactor binding
AhyD4_16025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AhyD4_16030	COG0583	DNA-binding transcription factor activity
AhyD4_16050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AhyD4_16055	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AhyD4_16060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AhyD4_16065	COG1454	alcohol dehydrogenase
AhyD4_16065	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_16075	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_16075	COG1454	alcohol dehydrogenase
AhyD4_16080	COG1882	Formate acetyltransferase
AhyD4_16085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_16090	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AhyD4_16095	COG4869	propanediol catabolic process
AhyD4_16140	COG2731	YhcH YjgK YiaL family protein
AhyD4_16145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_16155	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AhyD4_16160	COG1737	Transcriptional regulator
AhyD4_16165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_16170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AhyD4_16175	COG1349	DNA-binding transcription factor activity
AhyD4_16180	COG0738	Major facilitator superfamily
AhyD4_16190	COG1070	Carbohydrate kinase
AhyD4_16210	COG4172	Belongs to the ABC transporter superfamily
AhyD4_16215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_16225	COG0747	negative chemotaxis
AhyD4_16235	COG1388	LysM domain
AhyD4_16235	COG1376	ErfK ybiS ycfS ynhG family protein
AhyD4_16250	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AhyD4_16255	COG0791	NLP P60 protein
AhyD4_16260	COG2091	lysine biosynthetic process via aminoadipic acid
AhyD4_16265	COG3118	belongs to the thioredoxin family
AhyD4_16275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AhyD4_16280	COG0788	formyltetrahydrofolate deformylase activity
AhyD4_16290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_16310	COG0366	Alpha amylase catalytic
AhyD4_16315	COG1196	nuclear chromosome segregation
AhyD4_16315	COG0739	heme binding
AhyD4_16315	COG0741	lytic transglycosylase activity
AhyD4_16320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AhyD4_16325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AhyD4_16335	COG0673	inositol 2-dehydrogenase activity
AhyD4_16355	COG1032	radical SAM domain protein
AhyD4_16365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_16370	COG1566	PFAM secretion protein HlyD family protein
AhyD4_16375	COG2203	Gaf domain
AhyD4_16375	COG2199	diguanylate cyclase activity
AhyD4_16380	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhyD4_16385	COG0733	neurotransmitter:sodium symporter activity
AhyD4_16415	COG0281	malic enzyme
AhyD4_16425	COG0534	Mate efflux family protein
AhyD4_16435	COG3706	GGDEF domain
AhyD4_16435	COG0745	RESPONSE REGULATOR receiver
AhyD4_16440	COG2233	PERMEase
AhyD4_16445	COG0095	Lipoate-protein ligase
AhyD4_16450	COG1115	amino acid carrier protein
AhyD4_16455	COG0019	diaminopimelate decarboxylase activity
AhyD4_16465	COG0678	peroxiredoxin activity
AhyD4_16475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AhyD4_16495	COG1131	(ABC) transporter
AhyD4_16500	COG0545	Peptidyl-prolyl cis-trans isomerase
AhyD4_16505	COG3142	Participates in the control of copper homeostasis
AhyD4_16520	COG4783	chaperone-mediated protein folding
AhyD4_16530	COG5002	protein histidine kinase activity
AhyD4_16535	COG0745	RESPONSE REGULATOR receiver
AhyD4_16540	COG0346	lactoylglutathione lyase activity
AhyD4_16545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AhyD4_16550	COG1960	acyl-CoA dehydrogenase activity
AhyD4_16555	COG3284	Transcriptional regulator
AhyD4_16560	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_16570	COG0697	spore germination
AhyD4_16575	COG4565	transcriptional regulatory protein
AhyD4_16580	COG3290	protein histidine kinase activity
AhyD4_16585	COG0281	malic enzyme
AhyD4_16595	COG1846	Transcriptional regulator
AhyD4_16600	COG1566	PFAM secretion protein HlyD family protein
AhyD4_16625	COG0602	queuosine metabolic process
AhyD4_16630	COG1328	CTP reductase activity
AhyD4_16640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AhyD4_16645	COG3115	cell septum assembly
AhyD4_16650	COG1196	nuclear chromosome segregation
AhyD4_16660	COG2860	membrane
AhyD4_16670	COG3108	Peptidase M15
AhyD4_16675	COG2989	Protein conserved in bacteria
AhyD4_16690	COG0463	Glycosyl transferase, family 2
AhyD4_16705	COG0366	Alpha amylase catalytic
AhyD4_16740	COG3706	GGDEF domain
AhyD4_16745	COG0037	tRNA processing
AhyD4_16750	COG3590	peptidase
AhyD4_16760	COG0488	(ABC) transporter
AhyD4_16770	COG0531	amino acid
AhyD4_16785	COG0814	amino acid
AhyD4_16800	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AhyD4_16805	COG1982	Orn Lys Arg decarboxylase major
AhyD4_16810	COG0531	amino acid
AhyD4_16815	COG3710	Transcriptional regulator
AhyD4_16820	COG0825	malonyl-CoA metabolic process
AhyD4_16830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AhyD4_16835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_16840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_16845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AhyD4_16850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_16865	COG0750	zinc metalloprotease
AhyD4_16870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AhyD4_16875	COG0575	Belongs to the CDS family
AhyD4_16885	COG0233	cytoplasmic translational termination
AhyD4_16890	COG0528	UMP kinase activity
AhyD4_16895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AhyD4_16900	COG0052	Belongs to the universal ribosomal protein uS2 family
AhyD4_16905	COG0024	Methionine aminopeptidase
AhyD4_16910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AhyD4_16915	COG2171	N-acyltransferase activity
AhyD4_16925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_16925	COG1263	PTS System
AhyD4_16935	COG4580	involved in the transport of maltose and maltodextrins
AhyD4_16945	COG0564	pseudouridine synthase activity
AhyD4_16950	COG3098	single-species biofilm formation
AhyD4_16975	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AhyD4_16985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AhyD4_16985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AhyD4_16995	COG3706	GGDEF domain
AhyD4_17000	COG1611	Belongs to the LOG family
AhyD4_17005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_17010	COG0473	3-isopropylmalate dehydrogenase activity
AhyD4_17020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AhyD4_17025	COG2363	Small membrane protein
AhyD4_17035	COG0583	DNA-binding transcription factor activity
AhyD4_17040	COG0840	transmembrane signaling receptor activity
AhyD4_17045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhyD4_17060	COG1477	protein flavinylation
AhyD4_17065	COG2871	sodium ion transport
AhyD4_17070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_17075	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_17080	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_17085	COG1805	sodium ion transport
AhyD4_17090	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_17095	COG0271	Belongs to the BolA IbaG family
AhyD4_17100	COG2813	Specifically methylates the guanine in position
AhyD4_17110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AhyD4_17120	COG2211	Major facilitator Superfamily
AhyD4_17125	COG3248	Nucleoside-binding outer membrane protein
AhyD4_17130	COG1666	GTP binding
AhyD4_17135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AhyD4_17140	COG0693	protein deglycase activity
AhyD4_17185	COG2771	luxR family
AhyD4_17195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_17195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_17200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AhyD4_17210	COG1151	hydroxylamine reductase activity
AhyD4_17215	COG0783	Belongs to the Dps family
AhyD4_17240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AhyD4_17255	COG4221	oxidoreductase activity
AhyD4_17265	COG0415	Belongs to the DNA photolyase family
AhyD4_17270	COG0789	Transcriptional regulator
AhyD4_17275	COG3272	Protein of unknown function (DUF1722)
AhyD4_17305	COG1605	Chorismate mutase
AhyD4_17305	COG0077	Prephenate dehydratase
AhyD4_17335	COG5377	YqaJ viral recombinase family
AhyD4_17380	COG2003	Belongs to the UPF0758 family
AhyD4_17390	COG0602	queuosine metabolic process
AhyD4_17395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AhyD4_17430	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_17435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AhyD4_17460	COG4771	TonB-dependent receptor
AhyD4_17520	COG2226	methyltransferase
AhyD4_17550	COG2133	pyrroloquinoline quinone binding
AhyD4_17560	COG0840	transmembrane signaling receptor activity
AhyD4_17570	COG0300	oxidoreductase activity
AhyD4_17590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AhyD4_17605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AhyD4_17610	COG0826	peptidase U32
AhyD4_17615	COG1280	lysine exporter protein (LysE YggA)
AhyD4_17630	COG0840	transmembrane signaling receptor activity
AhyD4_17635	COG0745	RESPONSE REGULATOR receiver
AhyD4_17645	COG2198	Histidine kinase
AhyD4_17645	COG0643	Histidine kinase
AhyD4_17655	COG0835	chemotaxis
AhyD4_17660	COG0840	transmembrane signaling receptor activity
AhyD4_17670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AhyD4_17675	COG2201	protein-glutamate methylesterase activity
AhyD4_17680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AhyD4_17710	COG2200	EAL domain
AhyD4_17710	COG2199	diguanylate cyclase activity
AhyD4_17710	COG2203	Gaf domain
AhyD4_17720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_17725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_17730	COG0305	Participates in initiation and elongation during chromosome replication
AhyD4_17740	COG2200	EAL domain
AhyD4_17745	COG0737	Belongs to the 5'-nucleotidase family
AhyD4_17765	COG2204	response regulator
AhyD4_17770	COG0545	Peptidyl-prolyl cis-trans isomerase
AhyD4_17780	COG2900	Belongs to the SlyX family
AhyD4_17785	COG1047	Peptidyl-prolyl cis-trans
AhyD4_17790	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AhyD4_17800	COG0835	chemotaxis
AhyD4_17800	COG0784	Response regulator, receiver
AhyD4_17805	COG0429	hydrolase of the alpha beta-hydrolase fold
AhyD4_17810	COG3706	GGDEF domain
AhyD4_17810	COG5001	Diguanylate cyclase
AhyD4_17810	COG2203	Gaf domain
AhyD4_17810	COG4251	negative regulation of phosphorylation
AhyD4_17815	COG3089	Belongs to the UPF0270 family
AhyD4_17825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AhyD4_17830	COG0463	Glycosyl transferase, family 2
AhyD4_17835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AhyD4_17835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_17840	COG0726	polysaccharide deacetylase
AhyD4_17845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AhyD4_17850	COG2076	Multidrug Resistance protein
AhyD4_17855	COG2076	Multidrug Resistance protein
AhyD4_17860	COG3954	Phosphoribulokinase
AhyD4_17875	COG1765	OsmC-like protein
AhyD4_17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhyD4_17885	COG2226	methyltransferase
AhyD4_17890	COG3397	chitin binding
AhyD4_17905	COG2205	protein histidine kinase activity
AhyD4_17905	COG2202	Pas domain
AhyD4_17915	COG3655	Transcriptional regulator
AhyD4_17920	COG2814	Major facilitator Superfamily
AhyD4_17925	COG4771	TonB-dependent receptor
AhyD4_17945	COG0748	coenzyme F420 binding
AhyD4_17950	COG3721	Heme iron utilization protein
AhyD4_17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_17985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AhyD4_17990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_17995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AhyD4_18015	COG0741	lytic transglycosylase activity
AhyD4_18020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AhyD4_18115	COG0616	signal peptide processing
AhyD4_18130	COG1802	Transcriptional regulator
AhyD4_18130	COG4626	Terminase
AhyD4_18180	COG0464	growth
AhyD4_18305	COG0582	viral genome integration into host DNA
AhyD4_18310	COG0488	(ABC) transporter
AhyD4_18320	COG2252	PERMEase
AhyD4_18325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AhyD4_18330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AhyD4_18340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AhyD4_18350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AhyD4_18355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AhyD4_18365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AhyD4_18375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AhyD4_18380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_18395	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_18405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AhyD4_18410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AhyD4_18415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AhyD4_18420	COG0142	geranyltranstransferase activity
AhyD4_18425	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AhyD4_18430	COG0330	HflC and HflK could
AhyD4_18435	COG0330	HflC and HflK could
AhyD4_18440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AhyD4_18445	COG1923	regulation of RNA biosynthetic process
AhyD4_18450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AhyD4_18455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AhyD4_18465	COG0802	atpase or kinase
AhyD4_18470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AhyD4_18470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AhyD4_18495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AhyD4_18500	COG2011	ABC-type metal ion transport system permease component
AhyD4_18505	COG1464	Belongs to the NlpA lipoprotein family
AhyD4_18515	COG0840	transmembrane signaling receptor activity
AhyD4_18540	COG2198	Histidine kinase
AhyD4_18540	COG5002	protein histidine kinase activity
AhyD4_18540	COG0784	Response regulator, receiver
AhyD4_18560	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AhyD4_18575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AhyD4_18580	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AhyD4_18590	COG2716	regulation of RNA biosynthetic process
AhyD4_18595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AhyD4_18600	COG3013	Belongs to the UPF0304 family
AhyD4_18605	COG3092	negative regulation of chromosome organization
AhyD4_18610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AhyD4_18615	COG0857	belongs to the CobB CobQ family
AhyD4_18615	COG0280	phosphate acetyltransferase
AhyD4_18625	COG0028	Belongs to the TPP enzyme family
AhyD4_18635	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_18645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AhyD4_18650	COG0473	3-isopropylmalate dehydrogenase activity
AhyD4_18655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AhyD4_18660	COG0066	3-isopropylmalate dehydratase activity
AhyD4_18675	COG4143	(ABC) transporter
AhyD4_18680	COG1178	ABC-type Fe3 transport system permease component
AhyD4_18685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AhyD4_18690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AhyD4_18700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_18730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AhyD4_18735	COG0564	pseudouridine synthase activity
AhyD4_18745	COG3300	MHYT domain
AhyD4_18745	COG5001	Diguanylate cyclase
AhyD4_18755	COG0459	protein refolding
AhyD4_18760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AhyD4_18765	COG0534	Mate efflux family protein
AhyD4_18770	COG3030	protein affecting phage T7 exclusion by the F plasmid
AhyD4_18775	COG1027	Aspartate ammonia-lyase
AhyD4_18780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AhyD4_18790	COG0477	Major facilitator Superfamily
AhyD4_18810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AhyD4_18820	COG0673	inositol 2-dehydrogenase activity
AhyD4_18830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AhyD4_18835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AhyD4_18840	COG3036	rescue of stalled ribosome
AhyD4_18845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AhyD4_18855	COG0138	bifunctional purine biosynthesis protein purh
AhyD4_18860	COG0151	Belongs to the GarS family
AhyD4_18890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AhyD4_18895	COG0358	DNA primase activity
AhyD4_18900	COG1610	YqeY-like protein
AhyD4_18905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AhyD4_18915	COG1388	LysM domain
AhyD4_18915	COG4942	peptidase
AhyD4_18920	COG1238	metal cluster binding
AhyD4_18925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AhyD4_18930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AhyD4_18935	COG0585	pseudouridine synthase activity
AhyD4_18945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AhyD4_18950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AhyD4_18955	COG0148	phosphopyruvate hydratase activity
AhyD4_18960	COG0504	CTP synthase activity
AhyD4_18965	COG3956	TIGRFAM MazG family protein
AhyD4_18970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhyD4_18975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_18985	COG4807	Protein conserved in bacteria
AhyD4_18990	COG3023	N-Acetylmuramoyl-L-alanine amidase
AhyD4_18995	COG1349	DNA-binding transcription factor activity
AhyD4_19005	COG2222	sugar isomerase
AhyD4_19010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_19020	COG3716	PTS system mannose fructose sorbose family IID component
AhyD4_19025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_19030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_19045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AhyD4_19050	COG1381	Involved in DNA repair and RecF pathway recombination
AhyD4_19060	COG0571	ribonuclease III activity
AhyD4_19065	COG0681	Belongs to the peptidase S26 family
AhyD4_19070	COG0481	GTPase activity
AhyD4_19085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AhyD4_19090	COG1595	DNA-templated transcription, initiation
AhyD4_19095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AhyD4_19105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AhyD4_19110	COG0354	folic acid binding
AhyD4_19145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_19150	COG0191	fructose-bisphosphate aldolase activity
AhyD4_19155	COG0126	phosphoglycerate kinase activity
AhyD4_19160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AhyD4_19165	COG1940	carbohydrate kinase activity
AhyD4_19170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AhyD4_19185	COG4991	sh3 domain protein
AhyD4_19190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhyD4_19205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AhyD4_19225	COG1505	serine-type exopeptidase activity
AhyD4_19230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AhyD4_19235	COG0765	amino acid transport
AhyD4_19240	COG0765	amino acid transport
AhyD4_19245	COG1126	abc transporter atp-binding protein
AhyD4_19250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_19255	COG0577	efflux transmembrane transporter activity
AhyD4_19255	COG1136	(ABC) transporter
AhyD4_19260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_19265	COG0745	RESPONSE REGULATOR receiver
AhyD4_19270	COG2205	protein histidine kinase activity
AhyD4_19310	COG2070	2-Nitropropane dioxygenase
AhyD4_19335	COG1858	cytochrome C peroxidase
AhyD4_19340	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AhyD4_19360	COG0513	Belongs to the DEAD box helicase family
AhyD4_19375	COG0154	amidase activity
AhyD4_19380	COG2957	Belongs to the agmatine deiminase family
AhyD4_19395	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_19425	COG0745	RESPONSE REGULATOR receiver
AhyD4_19425	COG3706	GGDEF domain
AhyD4_19430	COG5001	Diguanylate cyclase
AhyD4_19440	COG0714	Associated with various cellular activities
AhyD4_19450	COG0456	acetyltransferase
AhyD4_19460	COG1022	Amp-dependent synthetase and ligase
AhyD4_19470	COG2918	glutathione biosynthetic process
AhyD4_19475	COG0612	Peptidase, M16
AhyD4_19480	COG1238	metal cluster binding
AhyD4_19500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_19505	COG0359	binds to the 23S rRNA
AhyD4_19510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AhyD4_19515	COG0360	Binds together with S18 to 16S ribosomal RNA
AhyD4_19520	COG1914	H( )-stimulated, divalent metal cation uptake system
AhyD4_19540	COG2153	protein acetylation
AhyD4_19550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhyD4_19555	COG0557	exoribonuclease II activity
AhyD4_19560	COG3706	GGDEF domain
AhyD4_19565	COG1854	S-ribosylhomocysteine lyase activity
AhyD4_19580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhyD4_19580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AhyD4_19640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AhyD4_19645	COG1047	Peptidyl-prolyl cis-trans
AhyD4_19650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AhyD4_19655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AhyD4_19660	COG0196	riboflavin kinase activity
AhyD4_19665	COG0728	peptidoglycan biosynthetic process
AhyD4_19670	COG0268	Binds directly to 16S ribosomal RNA
AhyD4_19675	COG0640	Transcriptional regulator
AhyD4_19680	COG0583	DNA-binding transcription factor activity
AhyD4_19690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_19695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AhyD4_19700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AhyD4_19710	COG1051	belongs to the nudix hydrolase family
AhyD4_19715	COG3066	DNA modification
AhyD4_19725	COG0335	large ribosomal subunit rRNA binding
AhyD4_19730	COG0336	Belongs to the RNA methyltransferase TrmD family
AhyD4_19735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AhyD4_19740	COG0228	four-way junction DNA binding
AhyD4_19745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AhyD4_19750	COG4137	Cytochrome C assembly protein
AhyD4_19755	COG4536	flavin adenine dinucleotide binding
AhyD4_19765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_19765	COG1017	nitric oxide dioxygenase activity
AhyD4_19770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AhyD4_19775	COG0039	L-malate dehydrogenase activity
AhyD4_19780	COG4160	amino acid transport
AhyD4_19785	COG4215	(ABC) transporter
AhyD4_19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_19795	COG1126	abc transporter atp-binding protein
AhyD4_19800	COG1438	arginine binding
AhyD4_19805	COG2837	iron assimilation
AhyD4_19810	COG3842	ATPase activity
AhyD4_19820	COG1840	ABC-type Fe3 transport system, periplasmic component
AhyD4_19825	COG0347	Belongs to the P(II) protein family
AhyD4_19840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_19845	COG0583	DNA-binding transcription factor activity
AhyD4_19860	COG1929	Belongs to the glycerate kinase type-1 family
AhyD4_19865	COG2610	gluconate transmembrane transporter activity
AhyD4_19870	COG3835	regulator
AhyD4_19875	COG3112	Uncharacterised protein family (UPF0231)
AhyD4_19890	COG0840	transmembrane signaling receptor activity
AhyD4_19895	COG3568	Endonuclease Exonuclease Phosphatase
AhyD4_19910	COG0513	Belongs to the DEAD box helicase family
AhyD4_19950	COG1448	Aminotransferase
AhyD4_19965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_19970	COG1328	CTP reductase activity
AhyD4_19990	COG0793	Belongs to the peptidase S41A family
AhyD4_19990	COG4946	Tricorn protease homolog
AhyD4_20020	COG0840	transmembrane signaling receptor activity
AhyD4_20025	COG3397	chitin binding
AhyD4_20030	COG0583	DNA-binding transcription factor activity
AhyD4_20035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AhyD4_20040	COG4208	sulfate ABC transporter
AhyD4_20045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AhyD4_20055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AhyD4_20060	COG3174	membrane
AhyD4_20065	COG0110	maltose O-acetyltransferase activity
AhyD4_20090	COG0165	Argininosuccinate lyase
AhyD4_20095	COG0137	argininosuccinate synthase activity
AhyD4_20105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AhyD4_20110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AhyD4_20120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AhyD4_20130	COG0460	homoserine dehydrogenase
AhyD4_20130	COG0527	aspartate kinase activity
AhyD4_20135	COG0626	cystathionine gamma-synthase activity
AhyD4_20145	COG3708	Transcriptional regulator
AhyD4_20145	COG2207	Transcriptional regulator
AhyD4_20150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_20155	COG0814	amino acid
AhyD4_20160	COG1218	3'(2'),5'-bisphosphate nucleotidase
AhyD4_20165	COG0494	nUDIX hydrolase
AhyD4_20170	COG1011	Hydrolase
AhyD4_20175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AhyD4_20190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AhyD4_20200	COG3156	type II secretion system protein K
AhyD4_20205	COG4795	General secretion pathway protein
AhyD4_20210	COG2165	general secretion pathway protein
AhyD4_20220	COG2165	general secretion pathway protein
AhyD4_20225	COG1459	type II secretion system
AhyD4_20230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_20240	COG3031	protein transport across the cell outer membrane
AhyD4_20250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AhyD4_20275	COG0456	acetyltransferase
AhyD4_20280	COG3133	Outer membrane lipoprotein
AhyD4_20295	COG2771	luxR family
AhyD4_20300	COG3916	Acyl-homoserine-lactone synthase
AhyD4_20310	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AhyD4_20315	COG1309	transcriptional regulator
AhyD4_20325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_20325	COG2213	PTS system mannitol-specific
AhyD4_20330	COG0246	Mannitol dehydrogenase
AhyD4_20335	COG3722	fumarate hydratase activity
AhyD4_20340	COG3263	regulation of cellular component size
AhyD4_20365	COG1671	Belongs to the UPF0178 family
AhyD4_20380	COG1988	membrane-bound metal-dependent
AhyD4_20385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_20390	COG0513	Belongs to the DEAD box helicase family
AhyD4_20415	COG1575	Belongs to the MenA family. Type 1 subfamily
AhyD4_20420	COG1169	isochorismate synthase
AhyD4_20425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AhyD4_20430	COG0596	Alpha beta hydrolase
AhyD4_20435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AhyD4_20440	COG1441	menaquinone biosynthetic process
AhyD4_20445	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_20460	COG3539	Fimbrial protein
AhyD4_20465	COG3121	Chaperone
AhyD4_20470	COG3188	usher protein
AhyD4_20480	COG3539	Fimbrial protein
AhyD4_20490	COG3291	Pkd domain containing protein
AhyD4_20495	COG2949	membrane
AhyD4_20510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AhyD4_20515	COG5380	lipid catabolic process
AhyD4_20530	COG4533	DNA binding
AhyD4_20535	COG2873	o-acetylhomoserine
AhyD4_20545	COG1979	alcohol dehydrogenase
AhyD4_20565	COG4221	oxidoreductase activity
AhyD4_20585	COG1285	pathogenesis
AhyD4_20605	COG1368	sulfuric ester hydrolase activity
AhyD4_20610	COG1522	sequence-specific DNA binding
AhyD4_20620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AhyD4_20625	COG1418	mRNA catabolic process
AhyD4_20630	COG1546	Belongs to the CinA family
AhyD4_20630	COG1058	Belongs to the CinA family
AhyD4_20645	COG1129	ABC transporter
AhyD4_20645	COG0842	Transport permease protein
AhyD4_20660	COG0561	phosphatase activity
AhyD4_20665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AhyD4_20685	COG1011	Hydrolase
AhyD4_20700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AhyD4_20705	COG0019	diaminopimelate decarboxylase activity
AhyD4_20710	COG1965	Belongs to the frataxin family
AhyD4_20715	COG0400	carboxylic ester hydrolase activity
AhyD4_20720	COG3072	Adenylate cyclase
AhyD4_20725	COG0181	hydroxymethylbilane synthase activity
AhyD4_20735	COG2959	enzyme of heme biosynthesis
AhyD4_20750	COG1494	fructose-1,6-bisphosphatase
AhyD4_20790	COG1733	regulation of RNA biosynthetic process
AhyD4_20810	COG3932	Exopolysaccharide synthesis, ExoD
AhyD4_20815	COG0814	amino acid
AhyD4_20820	COG3706	GGDEF domain
AhyD4_20835	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AhyD4_20845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AhyD4_20850	COG2022	thiamine diphosphate biosynthetic process
AhyD4_20860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AhyD4_20865	COG0352	thiamine-phosphate diphosphorylase activity
AhyD4_20870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AhyD4_20890	COG0745	RESPONSE REGULATOR receiver
AhyD4_20900	COG1114	Component of the transport system for branched-chain amino acids
AhyD4_20905	COG0189	ligase activity
AhyD4_20945	COG3171	Protein conserved in bacteria
AhyD4_20960	COG3188	usher protein
AhyD4_21010	COG1639	'signal transduction protein
AhyD4_21020	COG2321	neutral zinc metallopeptidase
AhyD4_21025	COG3700	Belongs to the class B bacterial acid phosphatase family
AhyD4_21045	COG1366	Belongs to the anti-sigma-factor antagonist family
AhyD4_21050	COG2172	sigma factor antagonist activity
AhyD4_21055	COG0784	Response regulator, receiver
AhyD4_21055	COG5002	protein histidine kinase activity
AhyD4_21055	COG2205	protein histidine kinase activity
AhyD4_21060	COG3437	response regulator, receiver
AhyD4_21070	COG0477	Major facilitator Superfamily
AhyD4_21085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AhyD4_21090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_21090	COG1263	PTS System
AhyD4_21110	COG0312	modulator of DNA gyrase
AhyD4_21115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhyD4_21125	COG3164	Protein of unknown function
AhyD4_21130	COG1530	ribonuclease E activity
AhyD4_21135	COG0424	maF-like protein
AhyD4_21140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AhyD4_21145	COG1792	Involved in formation and maintenance of cell shape
AhyD4_21150	COG1077	Cell shape determining protein MreB Mrl
AhyD4_21175	COG4968	Prepilin-type N-terminal cleavage methylation domain
AhyD4_21195	COG1459	type II secretion system
AhyD4_21200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_21210	COG2842	Transposition protein
AhyD4_21245	COG2200	EAL domain
AhyD4_21245	COG2199	diguanylate cyclase activity
AhyD4_21250	COG2200	EAL domain
AhyD4_21255	COG0387	Pfam Sodium calcium exchanger
AhyD4_21260	COG2986	histidine ammonia-lyase
AhyD4_21265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AhyD4_21270	COG0010	Belongs to the arginase family
AhyD4_21275	COG1228	amidohydrolase
AhyD4_21280	COG2188	Transcriptional regulator
AhyD4_21285	COG0288	reversible hydration of carbon dioxide
AhyD4_21295	COG2177	Part of the ABC transporter FtsEX involved in
AhyD4_21300	COG2884	Cell division ATP-binding protein ftsE
AhyD4_21305	COG0552	protein localization to endoplasmic reticulum
AhyD4_21310	COG0742	ribosomal rna small subunit methyltransferase
AhyD4_21335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_21340	COG0741	lytic transglycosylase activity
AhyD4_21360	COG2095	MarC family integral membrane protein
AhyD4_21370	COG1301	dicarboxylic acid transport
AhyD4_21395	COG3714	YhhN family
AhyD4_21410	COG1770	oligopeptidase
AhyD4_21425	COG4221	oxidoreductase activity
AhyD4_21430	COG0583	DNA-binding transcription factor activity
AhyD4_21435	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhyD4_21480	COG0203	ribosomal protein L17
AhyD4_21485	COG0202	RNA polymerase activity
AhyD4_21490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AhyD4_21495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AhyD4_21500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AhyD4_21505	COG0201	protein transport
AhyD4_21510	COG0200	Binds to the 23S rRNA
AhyD4_21515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AhyD4_21520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AhyD4_21525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AhyD4_21530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AhyD4_21535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AhyD4_21540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AhyD4_21545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AhyD4_21550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AhyD4_21555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AhyD4_21560	COG0255	Belongs to the universal ribosomal protein uL29 family
AhyD4_21565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AhyD4_21570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AhyD4_21575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AhyD4_21580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AhyD4_21585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AhyD4_21590	COG0089	rRNA binding
AhyD4_21595	COG0088	Forms part of the polypeptide exit tunnel
AhyD4_21600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AhyD4_21605	COG0051	transcription antitermination factor activity, RNA binding
AhyD4_21620	COG0745	RESPONSE REGULATOR receiver
AhyD4_21625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhyD4_21630	COG2183	response to ionizing radiation
AhyD4_21650	COG0596	Alpha beta hydrolase
AhyD4_21655	COG1040	competence protein
AhyD4_21660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AhyD4_21660	COG0316	Belongs to the HesB IscA family
AhyD4_21665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AhyD4_21670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AhyD4_21675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_21680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AhyD4_21685	COG4942	peptidase
AhyD4_21695	COG1609	Transcriptional regulator
AhyD4_21700	COG0800	Aldolase
AhyD4_21705	COG0129	dihydroxy-acid dehydratase activity
AhyD4_21710	COG3265	gluconokinase activity
AhyD4_21715	COG2610	gluconate transmembrane transporter activity
AhyD4_21720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_21725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AhyD4_21735	COG0456	acetyltransferase
AhyD4_21745	COG1490	D-aminoacyl-tRNA deacylase activity
AhyD4_21750	COG1295	ribonuclease BN
AhyD4_21760	COG0174	glutamine synthetase
AhyD4_21770	COG3852	Histidine kinase
AhyD4_21775	COG2204	response regulator
AhyD4_21780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AhyD4_21785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AhyD4_21795	COG3078	GTPase activator activity
AhyD4_21810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AhyD4_21820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AhyD4_21825	COG0408	coproporphyrinogen oxidase activity
AhyD4_21830	COG0009	L-threonylcarbamoyladenylate synthase
AhyD4_21840	COG0551	DNA topoisomerase type I activity
AhyD4_21845	COG2922	Belongs to the Smg family
AhyD4_21850	COG0758	DNA mediated transformation
AhyD4_21860	COG0242	peptide deformylase activity
AhyD4_21865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AhyD4_21870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_21870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_21875	COG0569	domain protein
AhyD4_21880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_21885	COG1322	Protein conserved in bacteria
AhyD4_21905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_21910	COG0686	Belongs to the AlaDH PNT family
AhyD4_21915	COG0519	Catalyzes the synthesis of GMP from XMP
AhyD4_21915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AhyD4_21930	COG1396	sequence-specific DNA binding
AhyD4_21935	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_21945	COG2962	Rard protein
AhyD4_21955	COG1280	lysine exporter protein (LysE YggA)
AhyD4_21965	COG2391	methyltransferase activity
AhyD4_21970	COG1280	lysine exporter protein (LysE YggA)
AhyD4_22015	COG0583	DNA-binding transcription factor activity
AhyD4_22020	COG1943	Transposase
AhyD4_22025	COG0210	DNA helicase
AhyD4_22050	COG0583	DNA-binding transcription factor activity
AhyD4_22070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AhyD4_22075	COG0385	Bile acid
AhyD4_22080	COG0531	amino acid
AhyD4_22085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_22090	COG0531	amino acid
AhyD4_22095	COG2731	YhcH YjgK YiaL family protein
AhyD4_22100	COG3250	beta-galactosidase activity
AhyD4_22105	COG1609	Transcriptional regulator
AhyD4_22140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AhyD4_22145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_22145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_22150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AhyD4_22155	COG3074	FtsZ-dependent cytokinesis
AhyD4_22165	COG1045	serine acetyltransferase
AhyD4_22175	COG0745	RESPONSE REGULATOR receiver
AhyD4_22180	COG2205	protein histidine kinase activity
AhyD4_22185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AhyD4_22190	COG0534	Mate efflux family protein
AhyD4_22205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhyD4_22210	COG2937	Belongs to the GPAT DAPAT family
AhyD4_22215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AhyD4_22220	COG3161	chorismate lyase activity
AhyD4_22225	COG1580	Controls the rotational direction of flagella during chemotaxis
AhyD4_22235	COG0604	alcohol dehydrogenase
AhyD4_22240	COG1609	Transcriptional regulator
AhyD4_22260	COG1519	Transferase
AhyD4_22265	COG0859	PFAM glycosyl transferase family 9
AhyD4_22270	COG0463	Glycosyl transferase, family 2
AhyD4_22275	COG0859	PFAM glycosyl transferase family 9
AhyD4_22280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AhyD4_22285	COG2990	Protein conserved in bacteria
AhyD4_22290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AhyD4_22300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AhyD4_22305	COG2003	Belongs to the UPF0758 family
AhyD4_22310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AhyD4_22315	COG0756	dUTP diphosphatase activity
AhyD4_22320	COG1309	transcriptional regulator
AhyD4_22325	COG0668	transmembrane transport
AhyD4_22335	COG0166	Belongs to the GPI family
AhyD4_22340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AhyD4_22345	COG0583	DNA-binding transcription factor activity
AhyD4_22385	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AhyD4_22390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_22395	COG1739	Uncharacterized protein family UPF0029
AhyD4_22400	COG0006	proline dipeptidase activity
AhyD4_22405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhyD4_22410	COG1250	3-hydroxyacyl-CoA dehydrogenase
AhyD4_22410	COG1024	Enoyl-CoA hydratase
AhyD4_22415	COG0183	Belongs to the thiolase family
AhyD4_22420	COG0745	RESPONSE REGULATOR receiver
AhyD4_22425	COG2205	protein histidine kinase activity
AhyD4_22440	COG0425	Belongs to the sulfur carrier protein TusA family
AhyD4_22445	COG0251	oxidation-reduction process
AhyD4_22450	COG2885	chlorophyll binding
AhyD4_22455	COG1335	isochorismatase
AhyD4_22460	COG2818	Glycosylase
AhyD4_22465	COG0752	glycyl-tRNA synthetase alpha subunit
AhyD4_22470	COG0751	glycine-tRNA ligase activity
AhyD4_22485	COG0529	Catalyzes the synthesis of activated sulfate
AhyD4_22485	COG2046	Belongs to the sulfate adenylyltransferase family
AhyD4_22505	COG0814	amino acid
AhyD4_22510	COG0348	domain, Protein
AhyD4_22520	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_22525	COG1773	rubredoxin
AhyD4_22525	COG0426	domain, Protein
AhyD4_22530	COG3604	Transcriptional regulator
AhyD4_22535	COG2188	Transcriptional regulator
AhyD4_22550	COG1609	Transcriptional regulator
AhyD4_22560	COG0559	Belongs to the binding-protein-dependent transport system permease family
AhyD4_22590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_22615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AhyD4_22625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AhyD4_22630	COG3118	belongs to the thioredoxin family
AhyD4_22635	COG0513	Belongs to the DEAD box helicase family
AhyD4_22640	COG0248	Ppx GppA phosphatase
AhyD4_22655	COG0742	ribosomal rna small subunit methyltransferase
AhyD4_22675	COG0084	hydrolase, TatD family'
AhyD4_22680	COG0805	protein transport
AhyD4_22685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AhyD4_22695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AhyD4_22700	COG3165	ubiquinone biosynthetic process from chorismate
AhyD4_22710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AhyD4_22715	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_22830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AhyD4_22835	COG0848	biopolymer transport protein
AhyD4_22840	COG0811	peptide transport
AhyD4_22845	COG0811	peptide transport
AhyD4_22855	COG2771	luxR family
AhyD4_22860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AhyD4_22865	COG1349	DNA-binding transcription factor activity
AhyD4_22870	COG0745	RESPONSE REGULATOR receiver
AhyD4_22875	COG2205	protein histidine kinase activity
AhyD4_22885	COG4452	Inner membrane protein CreD
AhyD4_22890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AhyD4_22895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AhyD4_22900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AhyD4_22905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AhyD4_22910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AhyD4_22915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AhyD4_22920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AhyD4_22930	COG0356	it plays a direct role in the translocation of protons across the membrane
AhyD4_22940	COG1475	DNA binding
AhyD4_22945	COG1192	Involved in chromosome partitioning
AhyD4_22950	COG0357	Ribosomal RNA small subunit methyltransferase G
AhyD4_22955	COG0445	tRNA wobble uridine modification
AhyD4_22960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AhyD4_22965	COG4774	siderophore transport
AhyD4_22970	COG4615	Cyclic peptide transporter
AhyD4_22975	COG1120	ATPase activity
AhyD4_22990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AhyD4_22995	COG0706	membrane insertase activity
AhyD4_23000	COG0594	ribonuclease P activity
AhyD4_23005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AhyD4_23070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AhyD4_23105	COG3550	peptidyl-serine autophosphorylation
AhyD4_23110	COG1396	sequence-specific DNA binding
AhyD4_23115	COG4974	Belongs to the 'phage' integrase family
AhyD4_23230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_23295	COG0714	Associated with various cellular activities
AhyD4_23450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AhyD4_23495	COG1192	Involved in chromosome partitioning
AhyD4_23500	COG1484	DNA-dependent DNA replication
AhyD4_23505	COG4584	PFAM Integrase catalytic
AhyD4_23560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AhyD4_23575	COG0776	regulation of translation
AhyD4_23640	COG2974	May be involved in recombination
AhyD4_23870	COG1192	Involved in chromosome partitioning