locus-tag	class	description
V469_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
V469_00010	COG0592	DNA-directed DNA polymerase activity
V469_00020	COG0187	DNA topoisomerase II activity
V469_00030	COG2378	regulation of single-species biofilm formation
V469_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
V469_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
V469_00045	COG3977	Valine--pyruvate aminotransferase
V469_00060	COG2814	Major facilitator Superfamily
V469_00065	COG0745	RESPONSE REGULATOR receiver
V469_00070	COG2205	protein histidine kinase activity
V469_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V469_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_00100	COG4191	Histidine kinase
V469_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V469_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_00115	COG1309	transcriptional regulator
V469_00145	COG0469	pyruvate kinase activity
V469_00150	COG2271	Major facilitator Superfamily
V469_00155	COG1840	ABC-type Fe3 transport system, periplasmic component
V469_00175	COG0561	phosphatase activity
V469_00180	COG2267	carboxylic ester hydrolase activity
V469_00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V469_00200	COG1758	RNA polymerase activity
V469_00210	COG0859	PFAM glycosyl transferase family 9
V469_00215	COG3642	lipopolysaccharide core region biosynthetic process
V469_00255	COG0589	response to stress
V469_00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V469_00265	COG2199	diguanylate cyclase activity
V469_00270	COG1528	Iron-storage protein
V469_00275	COG2081	HI0933 family
V469_00280	COG2223	nitrite transmembrane transporter activity
V469_00300	COG3188	usher protein
V469_00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_00320	COG2205	protein histidine kinase activity
V469_00330	COG3275	phosphorelay sensor kinase activity
V469_00335	COG3279	Response regulator of the LytR AlgR family
V469_00340	COG2223	nitrite transmembrane transporter activity
V469_00345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
V469_00350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
V469_00365	COG0583	DNA-binding transcription factor activity
V469_00370	COG4206	TonB-dependent receptor
V469_00375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
V469_00415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
V469_00420	COG2166	iron-sulfur cluster assembly
V469_00425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V469_00430	COG0210	DNA helicase
V469_00440	COG3245	cytochrome
V469_00445	COG1063	alcohol dehydrogenase
V469_00450	COG0156	8-amino-7-oxononanoate synthase activity
V469_00460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V469_00475	COG3306	glycosyltransferase involved in LPS biosynthesis
V469_00495	COG1561	YicC-like family, N-terminal region
V469_00500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
V469_00505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
V469_00520	COG0789	Transcriptional regulator
V469_00525	COG3706	GGDEF domain
V469_00525	COG2203	Gaf domain
V469_00525	COG4251	negative regulation of phosphorylation
V469_00525	COG5001	Diguanylate cyclase
V469_00530	COG3084	Protein conserved in bacteria
V469_00540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
V469_00545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V469_00550	COG3639	organic phosphonate transmembrane transporter activity
V469_00555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
V469_00560	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
V469_00570	COG1335	isochorismatase
V469_00580	COG1683	Conserved Protein
V469_00585	COG0204	Acyl-transferase
V469_00590	COG0204	Acyl-transferase
V469_00595	COG0606	chelatase, subunit chli
V469_00605	COG3978	acetolactate synthase activity
V469_00610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V469_00615	COG0129	dihydroxy-acid dehydratase activity
V469_00635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
V469_00640	COG0254	rRNA binding
V469_00645	COG0702	epimerase
V469_00650	COG0281	malic enzyme
V469_00660	COG2205	protein histidine kinase activity
V469_00665	COG0745	RESPONSE REGULATOR receiver
V469_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V469_00685	COG0366	Alpha amylase catalytic
V469_00700	COG0443	Heat shock 70 kDa protein
V469_00705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V469_00710	COG3045	CreA protein
V469_00725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
V469_00730	COG0174	glutamine synthetase
V469_00750	COG3842	ATPase activity
V469_00755	COG1176	ABC-type spermidine putrescine transport system, permease component I
V469_00760	COG1177	transmembrane transport
V469_00765	COG2258	MOSC domain
V469_00780	COG2050	protein possibly involved in aromatic compounds catabolism
V469_00785	COG0514	ATP-dependent DNA helicase (RecQ)
V469_00795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
V469_00805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
V469_00810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V469_00820	COG2239	Acts as a magnesium transporter
V469_00825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V469_00825	COG1648	precorrin-2 dehydrogenase activity
V469_00830	COG2116	formate transmembrane transporter activity
V469_00835	COG2146	nitrite reductase [NAD(P)H] activity
V469_00845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
V469_00860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
V469_00865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
V469_00885	COG1595	DNA-templated transcription, initiation
V469_00890	COG3806	Anti-sigma factor
V469_00895	COG1968	undecaprenyl-diphosphatase activity
V469_00900	COG0667	Aldo Keto reductase
V469_00905	COG2017	converts alpha-aldose to the beta-anomer
V469_00910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
V469_00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
V469_00925	COG1609	Transcriptional regulator
V469_00930	COG3250	beta-galactosidase activity
V469_00950	COG0840	transmembrane signaling receptor activity
V469_00980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
V469_00985	COG1288	antiporter activity
V469_00990	COG1438	arginine binding
V469_00995	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
V469_01000	COG0540	Belongs to the ATCase OTCase family
V469_01015	COG0688	phosphatidylethanolamine metabolic process
V469_01030	COG2207	Transcriptional regulator
V469_01035	COG1979	alcohol dehydrogenase
V469_01040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
V469_01045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
V469_01055	COG2964	Protein conserved in bacteria
V469_01060	COG3681	Belongs to the UPF0597 family
V469_01070	COG0446	pyridine nucleotide-disulphide oxidoreductase
V469_01075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V469_01080	COG0564	pseudouridine synthase activity
V469_01090	COG0542	response to heat
V469_01095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
V469_01100	COG2502	aspartate--ammonia ligase
V469_01105	COG1522	sequence-specific DNA binding
V469_01115	COG5413	integral membrane protein
V469_01140	COG2205	protein histidine kinase activity
V469_01150	COG2204	response regulator
V469_01170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
V469_01185	COG0745	RESPONSE REGULATOR receiver
V469_01190	COG2205	protein histidine kinase activity
V469_01200	COG0243	molybdopterin cofactor binding
V469_01205	COG3005	denitrification pathway
V469_01210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V469_01230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V469_01235	COG0569	domain protein
V469_01240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
V469_01265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V469_01275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V469_01280	COG0250	Participates in transcription elongation, termination and antitermination
V469_01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
V469_01290	COG0081	regulation of translation
V469_01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
V469_01300	COG0222	ribosome binding
V469_01305	COG0085	RNA polymerase activity
V469_01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
V469_01320	COG2964	Protein conserved in bacteria
V469_01325	COG0251	oxidation-reduction process
V469_01335	COG2923	Belongs to the DsrF TusC family
V469_01340	COG2168	tRNA wobble position uridine thiolation
V469_01345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
V469_01350	COG0049	tRNA binding
V469_01355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V469_01360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V469_01365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V469_01405	COG2252	PERMEase
V469_01410	COG2376	Dihydroxyacetone kinase
V469_01415	COG1461	Dihydroxyacetone kinase
V469_01430	COG3284	Transcriptional regulator
V469_01440	COG2957	Belongs to the agmatine deiminase family
V469_01445	COG4221	oxidoreductase activity
V469_01450	COG0628	permease
V469_01455	COG0494	nUDIX hydrolase
V469_01480	COG0753	catalase activity
V469_01485	COG1247	-acetyltransferase
V469_01505	COG3706	GGDEF domain
V469_01515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
V469_01525	COG1175	transmembrane transport
V469_01550	COG0583	DNA-binding transcription factor activity
V469_01560	COG1741	Belongs to the pirin family
V469_01565	COG2259	Doxx family
V469_01570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
V469_01575	COG1074	ATP-dependent DNA helicase activity
V469_01580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
V469_01590	COG0346	lactoylglutathione lyase activity
V469_01620	COG0745	RESPONSE REGULATOR receiver
V469_01625	COG2205	protein histidine kinase activity
V469_01630	COG3706	GGDEF domain
V469_01630	COG5001	Diguanylate cyclase
V469_01630	COG2203	Gaf domain
V469_01630	COG4251	negative regulation of phosphorylation
V469_01635	COG4771	TonB-dependent receptor
V469_01640	COG1278	Cold shock
V469_01665	COG0629	single-stranded DNA binding
V469_01670	COG2197	response regulator
V469_01675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
V469_01690	COG3047	cAMP biosynthetic process
V469_01695	COG0840	transmembrane signaling receptor activity
V469_01720	COG3135	benzoate transporter
V469_01725	COG1396	sequence-specific DNA binding
V469_01760	COG2926	Belongs to the UPF0265 family
V469_01770	COG3028	Belongs to the UPF0307 family
V469_01775	COG0312	modulator of DNA gyrase
V469_01780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
V469_01785	COG5007	Belongs to the BolA IbaG family
V469_01795	COG2854	intermembrane phospholipid transfer
V469_01800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V469_01805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
V469_01810	COG1127	ABC transporter
V469_01815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
V469_01815	COG0517	IMP dehydrogenase activity
V469_01820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
V469_01825	COG3117	lipopolysaccharide transmembrane transporter activity
V469_01830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
V469_01835	COG1137	ATPase activity
V469_01840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
V469_01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_01855	COG1660	Displays ATPase and GTPase activities
V469_01860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_01865	COG3711	transcriptional antiterminator
V469_01865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_01880	COG3964	amidohydrolase
V469_01910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V469_01915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V469_01925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
V469_01930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
V469_01935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V469_01940	COG0723	plastoquinol--plastocyanin reductase activity
V469_01945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
V469_01950	COG2857	Cytochrome c1
V469_01955	COG0625	glutathione transferase activity
V469_01960	COG2969	positive regulation of protein catabolic process
V469_01965	COG2823	Periplasmic or secreted lipoprotein
V469_01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V469_01975	COG0792	nuclease activity
V469_01980	COG3107	peptidoglycan biosynthetic process
V469_01985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
V469_01990	COG2001	Belongs to the MraZ family
V469_01995	COG0275	rRNA processing
V469_02000	COG3116	cell division
V469_02005	COG0768	penicillin binding
V469_02015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
V469_02020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
V469_02025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
V469_02030	COG0772	Belongs to the SEDS family
V469_02035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
V469_02040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V469_02045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
V469_02050	COG0849	cell division
V469_02055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
V469_02060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
V469_02070	COG0653	protein targeting
V469_02080	COG0494	nUDIX hydrolase
V469_02085	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
V469_02090	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
V469_02105	COG1459	type II secretion system
V469_02110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V469_02135	COG2186	Transcriptional regulator
V469_02140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
V469_02145	COG0508	dehydrogenase complex catalyzes the overall conversion of
V469_02150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V469_02155	COG3447	MASE1 domain protein
V469_02155	COG5001	Diguanylate cyclase
V469_02155	COG5002	protein histidine kinase activity
V469_02165	COG0840	transmembrane signaling receptor activity
V469_02170	COG0840	transmembrane signaling receptor activity
V469_02175	COG1752	Esterase of the alpha-beta hydrolase superfamily
V469_02180	COG1049	propionate catabolic process, 2-methylcitrate cycle
V469_02195	COG1280	lysine exporter protein (LysE YggA)
V469_02205	COG0523	cobalamin synthesis protein
V469_02210	COG0477	Major facilitator Superfamily
V469_02225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
V469_02230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
V469_02275	COG0835	chemotaxis
V469_02275	COG0784	Response regulator, receiver
V469_02280	COG1028	Short-chain dehydrogenase reductase Sdr
V469_02285	COG1444	tRNA N-acetyltransferase activity
V469_02310	COG1803	Methylglyoxal synthase
V469_02325	COG0252	asparaginase activity
V469_02345	COG1263	PTS System
V469_02345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_02350	COG0366	Alpha amylase catalytic
V469_02355	COG0110	maltose O-acetyltransferase activity
V469_02360	COG1522	sequence-specific DNA binding
V469_02365	COG5006	permease, DMT superfamily
V469_02375	COG1012	belongs to the aldehyde dehydrogenase family
V469_02380	COG1177	transmembrane transport
V469_02385	COG1176	ABC-type spermidine putrescine transport system, permease component I
V469_02390	COG3842	ATPase activity
V469_02395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V469_02400	COG0583	DNA-binding transcription factor activity
V469_02405	COG1757	Na H antiporter
V469_02450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V469_02455	COG2813	Specifically methylates the guanine in position
V469_02460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
V469_02465	COG4251	negative regulation of phosphorylation
V469_02465	COG3706	GGDEF domain
V469_02465	COG2203	Gaf domain
V469_02465	COG5001	Diguanylate cyclase
V469_02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V469_02485	COG2995	paraquat-inducible protein a
V469_02490	COG3008	intermembrane lipid transfer
V469_02490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V469_02495	COG3009	Protein conserved in bacteria
V469_02500	COG2885	chlorophyll binding
V469_02500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
V469_02510	COG3240	lipase activity
V469_02515	COG3111	PFAM Bacterial OB fold (BOF) protein
V469_02525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
V469_02530	COG1194	a g-specific adenine glycosylase
V469_02540	COG3267	Type II secretory pathway component ExeA
V469_02540	COG3409	Peptidoglycan-binding domain 1 protein
V469_02550	COG0617	tRNA 3'-terminal CCA addition
V469_02565	COG1346	cytolysis
V469_02570	COG1380	Effector of murein hydrolase LrgA
V469_02575	COG0583	DNA-binding transcription factor activity
V469_02600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
V469_02605	COG0306	phosphate transporter
V469_02610	COG1392	Phosphate transport regulator
V469_02625	COG1560	Kdo2-lipid A biosynthetic process
V469_02630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
V469_02630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
V469_02635	COG1538	Outer membrane efflux protein
V469_02640	COG0494	nUDIX hydrolase
V469_02645	COG3151	Protein conserved in bacteria
V469_02655	COG3150	esterase
V469_02660	COG1051	belongs to the nudix hydrolase family
V469_02675	COG1566	PFAM secretion protein HlyD family protein
V469_02680	COG1289	transmembrane transporter activity
V469_02685	COG0187	DNA topoisomerase II activity
V469_02730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
V469_02755	COG0204	Acyl-transferase
V469_02760	COG1842	Phage shock protein A
V469_02775	COG2827	Endonuclease containing a URI domain
V469_02785	COG2962	Rard protein
V469_02790	COG1573	uracil-dna glycosylase
V469_02795	COG0697	spore germination
V469_02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
V469_02810	COG1121	(ABC) transporter
V469_02815	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
V469_02835	COG0739	heme binding
V469_02845	COG3068	Protein conserved in bacteria
V469_02865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
V469_02885	COG1546	Belongs to the CinA family
V469_02890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
V469_02900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
V469_02905	COG0527	aspartate kinase activity
V469_02910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
V469_02940	COG1686	Belongs to the peptidase S11 family
V469_02945	COG0586	Pfam SNARE associated Golgi protein
V469_02950	COG1253	flavin adenine dinucleotide binding
V469_02955	COG0525	valine-tRNA ligase activity
V469_02960	COG2927	DNA polymerase III (CHI subunit)
V469_02965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V469_02970	COG0795	lipopolysaccharide-transporting ATPase activity
V469_02980	COG0795	lipopolysaccharide-transporting ATPase activity
V469_02995	COG0582	viral genome integration into host DNA
V469_03010	COG3561	AntA/AntB antirepressor
V469_03045	COG0004	ammonium transporteR
V469_03050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V469_03060	COG0084	hydrolase, TatD family'
V469_03065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V469_03075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
V469_03080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
V469_03085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
V469_03090	COG0813	purine-nucleoside phosphorylase activity
V469_03095	COG5001	Diguanylate cyclase
V469_03095	COG3447	MASE1 domain protein
V469_03095	COG5002	protein histidine kinase activity
V469_03105	COG0560	Phosphoserine phosphatase
V469_03130	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
V469_03135	COG0776	regulation of translation
V469_03150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V469_03155	COG0735	belongs to the Fur family
V469_03180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
V469_03185	COG0513	Belongs to the DEAD box helicase family
V469_03190	COG3022	response to hydroperoxide
V469_03205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
V469_03210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
V469_03215	COG0762	integral membrane protein
V469_03220	COG1872	DUF167
V469_03235	COG4166	transmembrane transport
V469_03245	COG0110	maltose O-acetyltransferase activity
V469_03260	COG1024	Enoyl-CoA hydratase
V469_03275	COG4221	oxidoreductase activity
V469_03280	COG0442	prolyl-tRNA aminoacylation
V469_03285	COG0840	transmembrane signaling receptor activity
V469_03290	COG0632	four-way junction helicase activity
V469_03295	COG2255	four-way junction helicase activity
V469_03300	COG1271	oxidase subunit
V469_03305	COG1294	oxidase, subunit
V469_03310	COG4890	Cyd operon protein YbgT
V469_03315	COG3790	cyd operon protein YbgE
V469_03320	COG0824	Thioesterase
V469_03325	COG0811	peptide transport
V469_03340	COG0823	Involved in the tonB-independent uptake of proteins
V469_03345	COG2885	chlorophyll binding
V469_03350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
V469_03385	COG0840	transmembrane signaling receptor activity
V469_03390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
V469_03395	COG0676	glucose-6-phosphate 1-epimerase activity
V469_03400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V469_03405	COG1640	4-alpha-glucanotransferase
V469_03410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
V469_03430	COG1051	belongs to the nudix hydrolase family
V469_03435	COG2130	NADP-dependent
V469_03440	COG1764	response to oxidative stress
V469_03445	COG1846	Transcriptional regulator
V469_03460	COG1522	sequence-specific DNA binding
V469_03475	COG0561	phosphatase activity
V469_03490	COG0733	neurotransmitter:sodium symporter activity
V469_03500	COG0733	neurotransmitter:sodium symporter activity
V469_03525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V469_03540	COG1794	racemase activity, acting on amino acids and derivatives
V469_03555	COG2731	YhcH YjgK YiaL family protein
V469_03565	COG0668	transmembrane transport
V469_03575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V469_03615	COG0583	DNA-binding transcription factor activity
V469_03620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
V469_03630	COG0488	(ABC) transporter
V469_03635	COG0517	IMP dehydrogenase activity
V469_03635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
V469_03640	COG1585	Membrane protein implicated in regulation of membrane protease activity
V469_03645	COG0330	HflC and HflK could
V469_03650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V469_03650	COG1648	precorrin-2 dehydrogenase activity
V469_03655	COG0175	sulfate reduction
V469_03660	COG2895	sulfate adenylyltransferase (ATP) activity
V469_03665	COG3273	potassium ion transport
V469_03665	COG0471	metal ion transport
V469_03670	COG0529	Catalyzes the synthesis of activated sulfate
V469_03690	COG0840	transmembrane signaling receptor activity
V469_03725	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
V469_03740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
V469_03745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V469_03750	COG0163	prenyltransferase activity
V469_03765	COG1131	(ABC) transporter
V469_03770	COG0842	Transport permease protein
V469_03775	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
V469_03780	COG1924	4 iron, 4 sulfur cluster binding
V469_03800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
V469_03805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
V469_03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V469_03825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
V469_03830	COG1489	DNA binding
V469_03840	COG1643	Atp-dependent helicase
V469_03845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V469_03850	COG0346	lactoylglutathione lyase activity
V469_03860	COG2076	Multidrug Resistance protein
V469_03870	COG3437	response regulator, receiver
V469_03870	COG0784	Response regulator, receiver
V469_03880	COG0671	phosphoesterase, PA-phosphatase related
V469_03895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
V469_03900	COG0038	chloride channel
V469_03910	COG0316	Belongs to the HesB IscA family
V469_03935	COG1280	lysine exporter protein (LysE YggA)
V469_03940	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
V469_03955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_03985	COG0745	RESPONSE REGULATOR receiver
V469_03990	COG3104	oligopeptide transport
V469_03995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
V469_04000	COG1555	photosystem II stabilization
V469_04010	COG2350	Protein conserved in bacteria
V469_04015	COG2917	probably involved in intracellular septation
V469_04020	COG0076	glutamate decarboxylase activity
V469_04025	COG1272	protein, Hemolysin III
V469_04030	COG0569	domain protein
V469_04030	COG2985	domain, Protein
V469_04045	COG0784	Response regulator, receiver
V469_04045	COG0835	chemotaxis
V469_04050	COG2755	lipolytic protein G-D-S-L family
V469_04055	COG4181	ATPase activity
V469_04060	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
V469_04065	COG1090	epimerase
V469_04070	COG2200	EAL domain
V469_04075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V469_04080	COG4935	Belongs to the peptidase S8 family
V469_04080	COG2234	aminopeptidase activity
V469_04085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
V469_04090	COG3171	Protein conserved in bacteria
V469_04095	COG2066	Belongs to the glutaminase family
V469_04100	COG2897	thiosulfate sulfurtransferase activity
V469_04105	COG1404	Belongs to the peptidase S8 family
V469_04115	COG1132	(ABC) transporter
V469_04140	COG3291	Pkd domain containing protein
V469_04140	COG4412	M6 family metalloprotease domain protein
V469_04145	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
V469_04150	COG5001	Diguanylate cyclase
V469_04150	COG3300	MHYT domain
V469_04170	COG4628	conserved protein (DUF2132)
V469_04175	COG0688	phosphatidylethanolamine metabolic process
V469_04180	COG1162	GTPase activity
V469_04185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
V469_04205	COG1278	Cold shock
V469_04215	COG0840	transmembrane signaling receptor activity
V469_04220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V469_04275	COG0848	biopolymer transport protein
V469_04280	COG0811	peptide transport
V469_04285	COG0811	peptide transport
V469_04300	COG4174	ABC transporter (Permease)
V469_04305	COG4239	(ABC) transporter, permease
V469_04315	COG0444	Belongs to the ABC transporter superfamily
V469_04320	COG4608	Belongs to the ABC transporter superfamily
V469_04330	COG2195	Cleaves the N-terminal amino acid of tripeptides
V469_04335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
V469_04355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
V469_04380	COG0243	molybdopterin cofactor binding
V469_04395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
V469_04395	COG1116	anion transmembrane transporter activity
V469_04400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
V469_04405	COG1116	anion transmembrane transporter activity
V469_04410	COG2146	nitrite reductase [NAD(P)H] activity
V469_04410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
V469_04415	COG2146	nitrite reductase [NAD(P)H] activity
V469_04415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
V469_04420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V469_04425	COG2313	pseudouridylate synthase activity
V469_04435	COG1858	cytochrome C peroxidase
V469_04470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V469_04475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V469_04500	COG2986	histidine ammonia-lyase
V469_04525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V469_04535	COG1028	Short-chain dehydrogenase reductase Sdr
V469_04550	COG0521	Mo-molybdopterin cofactor biosynthetic process
V469_04560	COG2966	Psort location CytoplasmicMembrane, score
V469_04565	COG3610	response to peptide
V469_04575	COG4175	Glycine betaine
V469_04580	COG4176	ABC-type proline glycine betaine transport system permease component
V469_04585	COG2113	Glycine betaine
V469_04590	COG0175	sulfate reduction
V469_04595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
V469_04600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V469_04605	COG0384	phenazine biosynthesis protein PhzF
V469_04610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
V469_04615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
V469_04625	COG0786	glutamate:sodium symporter activity
V469_04630	COG0252	asparaginase activity
V469_04635	COG3139	Protein of unknown function (DUF1315)
V469_04655	COG0616	signal peptide processing
V469_04660	COG1902	pentaerythritol trinitrate reductase activity
V469_04660	COG0446	pyridine nucleotide-disulphide oxidoreductase
V469_04665	COG0778	Nitroreductase
V469_04680	COG2264	protein methyltransferase activity
V469_04685	COG0604	alcohol dehydrogenase
V469_04690	COG0583	DNA-binding transcription factor activity
V469_04695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_04695	COG2190	(PTS) system
V469_04695	COG1263	PTS System
V469_04700	COG4145	pantothenate transmembrane transporter activity
V469_04710	COG0439	Biotin carboxylase
V469_04715	COG0511	ligase activity, forming carbon-carbon bonds
V469_04720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
V469_04730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V469_04740	COG3300	MHYT domain
V469_04740	COG5001	Diguanylate cyclase
V469_04760	COG3381	protein complex oligomerization
V469_04775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V469_04790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
V469_04795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V469_04795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V469_04815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
V469_04820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V469_04825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
V469_04830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
V469_04855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
V469_04860	COG0142	geranyltranstransferase activity
V469_04865	COG1722	exodeoxyribonuclease VII activity
V469_04870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V469_04875	COG1360	Flagellar Motor Protein
V469_04880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V469_04890	COG1534	Rna-binding protein
V469_04895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
V469_04900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
V469_04905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
V469_04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V469_04915	COG0149	triose-phosphate isomerase activity
V469_04920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V469_04935	COG0779	Required for maturation of 30S ribosomal subunits
V469_04940	COG0195	Participates in both transcription termination and antitermination
V469_04945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
V469_04950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
V469_04955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
V469_04960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
V469_04965	COG1185	polyribonucleotide nucleotidyltransferase activity
V469_04980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
V469_04990	COG0114	fumarate hydratase activity
V469_05000	COG1966	Carbon starvation protein
V469_05005	COG3279	Response regulator of the LytR AlgR family
V469_05080	COG0312	modulator of DNA gyrase
V469_05085	COG0312	modulator of DNA gyrase
V469_05090	COG0716	FMN binding
V469_05095	COG4974	Belongs to the 'phage' integrase family
V469_05100	COG1970	mechanosensitive ion channel activity
V469_05105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V469_05115	COG0789	Transcriptional regulator
V469_05130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V469_05135	COG3545	Serine hydrolase
V469_05145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
V469_05155	COG0321	lipoyl(octanoyl) transferase activity
V469_05160	COG2921	Belongs to the UPF0250 family
V469_05165	COG1686	Belongs to the peptidase S11 family
V469_05170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V469_05175	COG2951	lytic endotransglycosylase activity
V469_05185	COG0772	Belongs to the SEDS family
V469_05190	COG0768	penicillin binding
V469_05195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
V469_05200	COG0799	negative regulation of ribosome biogenesis
V469_05205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
V469_05220	COG0495	leucyl-tRNA aminoacylation
V469_05225	COG2888	peptidyl-tyrosine sulfation
V469_05230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
V469_05235	COG4535	Mg2 and Co2 transporter CorC
V469_05240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
V469_05245	COG1702	phosphate starvation-inducible protein PhoH
V469_05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V469_05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V469_05260	COG1335	isochorismatase
V469_05270	COG3706	GGDEF domain
V469_05285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V469_05295	COG3706	GGDEF domain
V469_05305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V469_05315	COG3647	Membrane
V469_05320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V469_05330	COG0516	GMP reductase activity
V469_05340	COG0642	Histidine kinase
V469_05345	COG0745	RESPONSE REGULATOR receiver
V469_05380	COG3214	Protein conserved in bacteria
V469_05405	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
V469_05410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
V469_05415	COG1053	succinate dehydrogenase
V469_05425	COG0584	glycerophosphoryl diester phosphodiesterase
V469_05430	COG1511	domain protein
V469_05430	COG3264	Mechanosensitive ion channel
V469_05440	COG0739	heme binding
V469_05455	COG0583	DNA-binding transcription factor activity
V469_05475	COG0583	DNA-binding transcription factor activity
V469_05480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
V469_05510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
V469_05515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
V469_05525	COG0338	D12 class N6 adenine-specific DNA methyltransferase
V469_05530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
V469_05540	COG0180	Tryptophanyl-tRNA synthetase
V469_05555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
V469_05565	COG1012	belongs to the aldehyde dehydrogenase family
V469_05575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V469_05585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_05585	COG0674	pyruvate-flavodoxin oxidoreductase activity
V469_05585	COG1013	pyruvate-flavodoxin oxidoreductase activity
V469_05585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
V469_05595	COG0366	Alpha amylase catalytic
V469_05615	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V469_05625	COG0490	domain, Protein
V469_05625	COG0471	metal ion transport
V469_05670	COG0012	GTP binding
V469_05675	COG0193	aminoacyl-tRNA hydrolase activity
V469_05680	COG0737	Belongs to the 5'-nucleotidase family
V469_05685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
V469_05695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
V469_05700	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
V469_05705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
V469_05710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
V469_05715	COG2890	protein-(glutamine-N5) methyltransferase activity
V469_05725	COG2912	Transglutaminase-like superfamily
V469_05730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
V469_05735	COG1301	dicarboxylic acid transport
V469_05745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
V469_05760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
V469_05765	COG1115	amino acid carrier protein
V469_05780	COG0714	Associated with various cellular activities
V469_05790	COG3104	oligopeptide transport
V469_05795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
V469_05800	COG1678	Uncharacterized ACR, COG1678
V469_05810	COG0189	ligase activity
V469_05815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
V469_05825	COG3091	SprT-like family
V469_05835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V469_05875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
V469_05890	COG0739	heme binding
V469_05895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V469_05900	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
V469_05900	COG3408	Glycogen debranching enzyme
V469_05910	COG1881	PFAM PEBP family protein
V469_05920	COG0583	DNA-binding transcription factor activity
V469_05930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
V469_05940	COG0583	DNA-binding transcription factor activity
V469_05945	COG1028	Short-chain dehydrogenase reductase Sdr
V469_05950	COG0616	signal peptide processing
V469_05955	COG3724	N-succinylarginine dihydrolase activity
V469_05960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V469_05975	COG0840	transmembrane signaling receptor activity
V469_05990	COG2971	BadF BadG BcrA BcrD
V469_06000	COG4608	Belongs to the ABC transporter superfamily
V469_06005	COG0444	Belongs to the ABC transporter superfamily
V469_06010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V469_06015	COG0601	transmembrane transport
V469_06020	COG4166	transmembrane transport
V469_06055	COG3220	belongs to the UPF0276 family
V469_06085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V469_06090	COG1289	transmembrane transporter activity
V469_06095	COG0303	'Molybdopterin
V469_06100	COG0746	molybdenum cofactor guanylyltransferase activity
V469_06110	COG4662	Binding-protein-dependent transport system inner membrane component
V469_06120	COG2204	response regulator
V469_06125	COG3852	Histidine kinase
V469_06130	COG1910	domain protein
V469_06135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
V469_06175	COG3383	formate dehydrogenase (NAD+) activity
V469_06175	COG3383	formate dehydrogenase (NAD+) activity
V469_06180	COG0437	4 iron, 4 sulfur cluster binding
V469_06195	COG0281	malic enzyme
V469_06215	COG2706	6-phosphogluconolactonase activity
V469_06225	COG3264	Mechanosensitive ion channel
V469_06225	COG1196	nuclear chromosome segregation
V469_06230	COG0469	pyruvate kinase activity
V469_06245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V469_06245	COG4651	solute:proton antiporter activity
V469_06260	COG2974	May be involved in recombination
V469_06275	COG0419	ATPase involved in DNA repair
V469_06290	COG3038	cytochrome b561
V469_06305	COG2190	(PTS) system
V469_06315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_06320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
V469_06325	COG0542	response to heat
V469_06340	COG1720	tRNA m6t6A37 methyltransferase activity
V469_06360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
V469_06365	COG4988	ABC transporter
V469_06380	COG0745	RESPONSE REGULATOR receiver
V469_06395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V469_06410	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
V469_06415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
V469_06425	COG0083	homoserine kinase activity
V469_06430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
V469_06435	COG4319	ketosteroid isomerase
V469_06450	COG0488	(ABC) transporter
V469_06470	COG0813	purine-nucleoside phosphorylase activity
V469_06485	COG2205	protein histidine kinase activity
V469_06485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_06490	COG3384	dioxygenase
V469_06505	COG1283	sodium-dependent phosphate transmembrane transporter activity
V469_06515	COG0531	amino acid
V469_06525	COG0531	amino acid
V469_06545	COG1396	sequence-specific DNA binding
V469_06545	COG1917	Cupin 2, conserved barrel domain protein
V469_06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V469_06570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V469_06575	COG2375	cellular response to nickel ion
V469_06580	COG1538	Outer membrane efflux protein
V469_06585	COG0577	efflux transmembrane transporter activity
V469_06585	COG1136	(ABC) transporter
V469_06590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_06600	COG1227	inorganic diphosphatase activity
V469_06610	COG0497	DNA recombination
V469_06615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
V469_06620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
V469_06625	COG0443	Heat shock 70 kDa protein
V469_06630	COG0484	heat shock protein binding
V469_06660	COG1285	pathogenesis
V469_06675	COG0640	Transcriptional regulator
V469_06705	COG0095	Lipoate-protein ligase
V469_06725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V469_06730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_06750	COG0708	Exodeoxyribonuclease III
V469_06765	COG2211	Major facilitator Superfamily
V469_06810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
V469_06815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
V469_06820	COG1845	cytochrome c oxidase, subunit III
V469_06825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
V469_06830	COG0109	protoheme IX farnesyltransferase activity
V469_06835	COG2814	Major facilitator Superfamily
V469_06845	COG2175	clavaminate synthase activity
V469_06850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
V469_06855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
V469_06860	COG4521	taurine ABC transporter
V469_06870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V469_06895	COG1988	membrane-bound metal-dependent
V469_06910	COG0133	tryptophan synthase activity
V469_06915	COG0135	phosphoribosylanthranilate isomerase activity
V469_06915	COG0134	indole-3-glycerol-phosphate synthase activity
V469_06920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
V469_06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
V469_06925	COG0512	Glutamine amidotransferase of anthranilate synthase
V469_06930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V469_06940	COG0009	L-threonylcarbamoyladenylate synthase
V469_06950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
V469_06960	COG1946	Acyl-CoA thioesterase
V469_06980	COG1309	transcriptional regulator
V469_06985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_06990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V469_06995	COG1538	Outer membrane efflux protein
V469_07005	COG1091	dTDP-4-dehydrorhamnose reductase activity
V469_07045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
V469_07065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
V469_07080	COG1086	Polysaccharide biosynthesis protein
V469_07110	COG0489	protein tyrosine kinase activity
V469_07110	COG3206	protein involved in exopolysaccharide biosynthesis
V469_07120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V469_07130	COG3132	Protein of unknown function, DUF480
V469_07170	COG1278	Cold shock
V469_07200	COG0697	spore germination
V469_07205	COG1349	DNA-binding transcription factor activity
V469_07215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V469_07220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
V469_07235	COG1187	pseudouridine synthase activity
V469_07250	COG0622	Phosphoesterase
V469_07265	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
V469_07270	COG0784	Response regulator, receiver
V469_07270	COG0835	chemotaxis
V469_07275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V469_07280	COG1815	bacterial-type flagellum-dependent cell motility
V469_07285	COG1558	bacterial-type flagellum-dependent cell motility
V469_07300	COG4787	bacterial-type flagellum-dependent cell motility
V469_07305	COG4786	Flagellar basal body rod
V469_07310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
V469_07315	COG1706	bacterial-type flagellum-dependent cell motility
V469_07320	COG3951	Flagellar rod assembly protein muramidase FlgJ
V469_07320	COG1705	Flagellar rod assembly protein muramidase FlgJ
V469_07325	COG1256	bacterial-type flagellum assembly
V469_07335	COG2239	Acts as a magnesium transporter
V469_07340	COG0248	Ppx GppA phosphatase
V469_07345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
V469_07350	COG2716	regulation of RNA biosynthetic process
V469_07360	COG2204	response regulator
V469_07365	COG3852	Histidine kinase
V469_07370	COG2204	response regulator
V469_07375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
V469_07380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
V469_07385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
V469_07390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
V469_07410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
V469_07425	COG0590	tRNA wobble adenosine to inosine editing
V469_07430	COG0573	inorganic phosphate transmembrane transporter activity
V469_07435	COG0581	inorganic phosphate transmembrane transporter activity
V469_07450	COG0704	Plays a role in the regulation of phosphate uptake
V469_07455	COG1253	flavin adenine dinucleotide binding
V469_07470	COG0531	amino acid
V469_07485	COG1126	abc transporter atp-binding protein
V469_07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_07500	COG3706	GGDEF domain
V469_07505	COG2271	Major facilitator Superfamily
V469_07520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V469_07550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
V469_07555	COG0477	Major facilitator Superfamily
V469_07560	COG0123	including yeast histone deacetylase and acetoin utilization protein
V469_07570	COG1199	ATP-dependent helicase activity
V469_07585	COG1448	Aminotransferase
V469_07590	COG0433	COG0433 Predicted ATPase
V469_07700	COG2916	Histone family protein nucleoid-structuring protein H-NS
V469_07745	COG1663	tetraacyldisaccharide 4'-kinase activity
V469_07750	COG2835	tetraacyldisaccharide 4'-kinase activity
V469_07755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
V469_07760	COG2197	response regulator
V469_07765	COG0322	excinuclease ABC activity
V469_07790	COG0582	viral genome integration into host DNA
V469_07815	COG4372	Transposase
V469_07835	COG3962	Belongs to the TPP enzyme family
V469_07850	COG0673	inositol 2-dehydrogenase activity
V469_07855	COG1879	ABC-type sugar transport system periplasmic component
V469_07865	COG1172	Belongs to the binding-protein-dependent transport system permease family
V469_07870	COG0673	inositol 2-dehydrogenase activity
V469_07875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V469_07885	COG3718	enzyme involved in inositol metabolism
V469_07895	COG2963	transposase activity
V469_07900	COG2801	Transposase and inactivated derivatives
V469_07965	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
V469_07970	COG0437	4 iron, 4 sulfur cluster binding
V469_07975	COG3301	Polysulphide reductase, NrfD
V469_07980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V469_07990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V469_07995	COG0215	cysteine-tRNA ligase activity
V469_08015	COG2203	Gaf domain
V469_08015	COG2199	diguanylate cyclase activity
V469_08045	COG2119	membrane
V469_08050	COG0023	Translation Initiation Factor
V469_08075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V469_08090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_08090	COG2205	protein histidine kinase activity
V469_08100	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
V469_08110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V469_08115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
V469_08120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V469_08125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
V469_08130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
V469_08135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
V469_08145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
V469_08150	COG0505	Belongs to the CarA family
V469_08155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
V469_08160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
V469_08190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V469_08195	COG0513	Belongs to the DEAD box helicase family
V469_08205	COG4104	PAAR repeat-containing protein
V469_08220	COG0789	Transcriptional regulator
V469_08235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_08240	COG0765	amino acid transport
V469_08250	COG0493	'glutamate synthase
V469_08255	COG0069	glutamate synthase activity
V469_08255	COG0067	glutamate synthase
V469_08255	COG0070	glutamate synthase
V469_08260	COG1242	4 iron, 4 sulfur cluster binding
V469_08305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
V469_08310	COG0574	Belongs to the PEP-utilizing enzyme family
V469_08310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
V469_08365	COG1464	Belongs to the NlpA lipoprotein family
V469_08370	COG0671	phosphoesterase, PA-phosphatase related
V469_08375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V469_08380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V469_08390	COG0101	tRNA pseudouridine synthase activity
V469_08395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
V469_08400	COG0285	dihydrofolate synthase activity
V469_08405	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
V469_08410	COG2920	part of a sulfur-relay system
V469_08415	COG1289	transmembrane transporter activity
V469_08420	COG0670	Belongs to the BI1 family
V469_08440	COG2194	sulfuric ester hydrolase activity
V469_08450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
V469_08450	COG0392	lysyltransferase activity
V469_08460	COG0840	transmembrane signaling receptor activity
V469_08465	COG5001	Diguanylate cyclase
V469_08470	COG0564	pseudouridine synthase activity
V469_08485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
V469_08495	COG0625	glutathione transferase activity
V469_08500	COG0625	glutathione transferase activity
V469_08510	COG0367	asparagine synthase
V469_08520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V469_08520	COG4651	solute:proton antiporter activity
V469_08525	COG0647	UMP catabolic process
V469_08530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
V469_08535	COG1902	pentaerythritol trinitrate reductase activity
V469_08540	COG1253	flavin adenine dinucleotide binding
V469_08560	COG2050	protein possibly involved in aromatic compounds catabolism
V469_08570	COG2056	Na+-H+ antiporter family
V469_08575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V469_08590	COG0346	lactoylglutathione lyase activity
V469_08595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
V469_08605	COG4659	FMN binding
V469_08610	COG4658	electron transport chain
V469_08620	COG2878	Part of a membrane complex involved in electron transport
V469_08625	COG4657	Part of a membrane complex involved in electron transport
V469_08630	COG0697	spore germination
V469_08645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V469_08650	COG1288	antiporter activity
V469_08655	COG0436	Aminotransferase
V469_08665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V469_08670	COG2027	D-alanyl-D-alanine carboxypeptidase
V469_08675	COG1061	Type III restriction enzyme res subunit
V469_08680	COG1566	PFAM secretion protein HlyD family protein
V469_08690	COG1966	Carbon starvation protein
V469_08695	COG3279	Response regulator of the LytR AlgR family
V469_08700	COG3275	phosphorelay sensor kinase activity
V469_08705	COG2199	diguanylate cyclase activity
V469_08705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V469_08710	COG1012	belongs to the aldehyde dehydrogenase family
V469_08710	COG1454	alcohol dehydrogenase
V469_08720	COG2095	MarC family integral membrane protein
V469_08730	COG0601	transmembrane transport
V469_08735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V469_08740	COG0444	Belongs to the ABC transporter superfamily
V469_08755	COG0861	Integral membrane protein TerC family
V469_08760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V469_08770	COG1301	dicarboxylic acid transport
V469_08785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
V469_08800	COG0537	adenosine 5'-monophosphoramidase activity
V469_08835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V469_08840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V469_08850	COG2354	Protein conserved in bacteria
V469_08865	COG2233	PERMEase
V469_08875	COG1252	NADH dehydrogenase
V469_08895	COG0393	Putative heavy-metal-binding
V469_08905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V469_08905	COG1648	precorrin-2 dehydrogenase activity
V469_08910	COG2221	Nitrite and sulphite reductase 4Fe-4S
V469_08925	COG4667	esterase of the alpha-beta hydrolase superfamily
V469_08930	COG1619	proteins homologs of microcin C7 resistance protein MccF
V469_08935	COG1368	sulfuric ester hydrolase activity
V469_08945	COG0527	aspartate kinase activity
V469_08950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
V469_08950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V469_08955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V469_08980	COG0596	Alpha beta hydrolase
V469_08985	COG0346	lactoylglutathione lyase activity
V469_09005	COG1620	l-lactate permease
V469_09015	COG1139	Iron-sulfur cluster binding protein
V469_09040	COG1136	(ABC) transporter
V469_09050	COG2814	Major facilitator Superfamily
V469_09070	COG0672	)-iron permease
V469_09100	COG0659	secondary active sulfate transmembrane transporter activity
V469_09165	COG2963	transposase activity
V469_09190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V469_09195	COG0840	transmembrane signaling receptor activity
V469_09205	COG2201	protein-glutamate methylesterase activity
V469_09215	COG0835	chemotaxis
V469_09220	COG0840	transmembrane signaling receptor activity
V469_09220	COG3290	protein histidine kinase activity
V469_09225	COG2198	Histidine kinase
V469_09225	COG0643	Histidine kinase
V469_09235	COG0745	RESPONSE REGULATOR receiver
V469_09240	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
V469_09245	COG0437	4 iron, 4 sulfur cluster binding
V469_09250	COG5557	Pfam Polysulphide reductase, NrfD
V469_09255	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
V469_09260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
V469_09265	COG1773	rubredoxin
V469_09270	COG0747	negative chemotaxis
V469_09275	COG0601	transmembrane transport
V469_09280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V469_09285	COG0444	Belongs to the ABC transporter superfamily
V469_09290	COG3842	ATPase activity
V469_09305	COG0375	protein maturation
V469_09310	COG0309	Hydrogenase expression formation protein (HypE)
V469_09320	COG0298	carbon dioxide binding
V469_09325	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
V469_09335	COG1921	L-seryl-tRNASec selenium transferase activity
V469_09345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
V469_09355	COG3260	NADH ubiquinone oxidoreductase 20
V469_09360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_09365	COG3261	NADH dehydrogenase
V469_09365	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
V469_09370	COG0650	Formate hydrogenlyase subunit 4
V469_09375	COG0651	ATP synthesis coupled electron transport
V469_09380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_09385	COG3158	transport of potassium into the cell
V469_09395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_09400	COG3383	formate dehydrogenase (NAD+) activity
V469_09405	COG3383	formate dehydrogenase (NAD+) activity
V469_09425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
V469_09430	COG0326	Molecular chaperone. Has ATPase activity
V469_09435	COG0563	adenylate kinase activity
V469_09440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
V469_09450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V469_09465	COG3300	MHYT domain
V469_09465	COG5001	Diguanylate cyclase
V469_09470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V469_09490	COG1021	2,3-dihydroxybenzoate-AMP ligase
V469_09495	COG1535	isochorismatase
V469_09495	COG3433	isochorismatase activity
V469_09500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V469_09505	COG1028	Short-chain dehydrogenase reductase Sdr
V469_09515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V469_09520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
V469_09525	COG2977	Belongs to the P-Pant transferase superfamily
V469_09530	COG1120	ATPase activity
V469_09535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V469_09540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V469_09545	COG4771	TonB-dependent receptor
V469_09565	COG0598	Magnesium transport protein CorA
V469_09590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
V469_09595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
V469_09600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V469_09615	COG1570	exodeoxyribonuclease VII activity
V469_09620	COG0697	spore germination
V469_09640	COG3158	transport of potassium into the cell
V469_09645	COG0516	GMP reductase activity
V469_09645	COG0517	IMP dehydrogenase activity
V469_09650	COG0519	Catalyzes the synthesis of GMP from XMP
V469_09650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
V469_09655	COG0582	viral genome integration into host DNA
V469_09715	COG2169	Transcriptional regulator
V469_09715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
V469_09740	COG2062	phosphohistidine phosphatase, SixA
V469_09750	COG0697	spore germination
V469_09755	COG4166	transmembrane transport
V469_09760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
V469_09765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
V469_09775	COG4591	ABC-type transport system involved in lipoprotein release permease component
V469_09780	COG1136	(ABC) transporter
V469_09785	COG4591	ABC-type transport system involved in lipoprotein release permease component
V469_09790	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
V469_09800	COG0544	peptidyl-prolyl cis-trans isomerase activity
V469_09805	COG0740	serine-type endopeptidase activity
V469_09810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
V469_09815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
V469_09820	COG0776	regulation of translation
V469_09825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V469_09830	COG0488	(ABC) transporter
V469_09835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V469_09840	COG3162	membrane
V469_09855	COG1024	Enoyl-CoA hydratase
V469_09900	COG1115	amino acid carrier protein
V469_09915	COG1584	GPR1 FUN34 yaaH family protein
V469_09950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
V469_09955	COG1960	acyl-CoA dehydrogenase activity
V469_09965	COG1960	acyl-CoA dehydrogenase activity
V469_09970	COG1024	Enoyl-CoA hydratase
V469_09975	COG1024	Enoyl-CoA hydratase
V469_09985	COG1028	Short-chain dehydrogenase reductase Sdr
V469_09995	COG0730	response to heat
V469_10020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
V469_10045	COG1073	alpha beta
V469_10050	COG0823	Involved in the tonB-independent uptake of proteins
V469_10050	COG1506	peptidase
V469_10055	COG0702	epimerase
V469_10060	COG0583	DNA-binding transcription factor activity
V469_10065	COG0667	Aldo Keto reductase
V469_10080	COG3706	GGDEF domain
V469_10085	COG0583	DNA-binding transcription factor activity
V469_10090	COG2723	6-phospho-beta-galactosidase activity
V469_10110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V469_10115	COG1028	Short-chain dehydrogenase reductase Sdr
V469_10120	COG0583	DNA-binding transcription factor activity
V469_10125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
V469_10130	COG0673	inositol 2-dehydrogenase activity
V469_10135	COG0583	DNA-binding transcription factor activity
V469_10145	COG1560	Kdo2-lipid A biosynthetic process
V469_10150	COG1560	Kdo2-lipid A biosynthetic process
V469_10175	COG0417	DNA replication proofreading
V469_10205	COG0534	Mate efflux family protein
V469_10215	COG0307	riboflavin synthase, alpha
V469_10225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V469_10230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
V469_10235	COG0697	spore germination
V469_10240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
V469_10280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V469_10290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
V469_10295	COG2894	cell division
V469_10300	COG0850	regulation of cytokinetic process
V469_10305	COG3100	YcgL domain-containing protein
V469_10310	COG2951	lytic endotransglycosylase activity
V469_10315	COG1760	l-serine dehydratase
V469_10320	COG1760	l-serine dehydratase
V469_10325	COG3123	guanosine phosphorylase activity
V469_10345	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V469_10350	COG2067	long-chain fatty acid transport protein
V469_10365	COG1595	DNA-templated transcription, initiation
V469_10395	COG0714	Associated with various cellular activities
V469_10400	COG0183	Belongs to the thiolase family
V469_10405	COG1024	Enoyl-CoA hydratase
V469_10405	COG1250	3-hydroxyacyl-CoA dehydrogenase
V469_10415	COG4681	YaeQ
V469_10425	COG4383	Mu-like prophage protein gp29
V469_10445	COG4388	Caudovirus prohead serine protease
V469_10455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
V469_10460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
V469_10465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V469_10475	COG0549	Belongs to the carbamate kinase family
V469_10485	COG0697	spore germination
V469_10490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
V469_10490	COG3608	succinylglutamate desuccinylase aspartoacylase
V469_10495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
V469_10500	COG2068	MobA-Related Protein
V469_10510	COG0493	'glutamate synthase
V469_10510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_10515	COG0402	S-adenosylhomocysteine deaminase activity
V469_10520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
V469_10525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
V469_10525	COG2080	2 iron, 2 sulfur cluster binding
V469_10530	COG2233	PERMEase
V469_10535	COG0402	S-adenosylhomocysteine deaminase activity
V469_10540	COG2252	PERMEase
V469_10545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
V469_10550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
V469_10555	COG2080	2 iron, 2 sulfur cluster binding
V469_10565	COG3134	Outer membrane lipoprotein
V469_10575	COG1288	antiporter activity
V469_10580	COG0318	PFAM AMP-dependent synthetase and ligase
V469_10585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
V469_10585	COG0140	phosphoribosyl-ATP diphosphatase activity
V469_10590	COG0107	imidazoleglycerol-phosphate synthase activity
V469_10595	COG2205	protein histidine kinase activity
V469_10595	COG2198	Histidine kinase
V469_10595	COG0784	Response regulator, receiver
V469_10605	COG3437	response regulator, receiver
V469_10610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
V469_10615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
V469_10620	COG0131	Imidazoleglycerol-phosphate dehydratase
V469_10620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V469_10625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
V469_10630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
V469_10635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
V469_10645	COG1199	ATP-dependent helicase activity
V469_10650	COG1214	PFAM Peptidase M22, glycoprotease
V469_10660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
V469_10660	COG0596	Alpha beta hydrolase
V469_10660	COG2226	methyltransferase
V469_10665	COG0318	PFAM AMP-dependent synthetase and ligase
V469_10670	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
V469_10805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
V469_10815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V469_10820	COG2832	Protein of unknown function (DUF454)
V469_10825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
V469_10835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
V469_10840	COG0582	viral genome integration into host DNA
V469_10870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V469_10970	COG0753	catalase activity
V469_10995	COG3646	Phage regulatory protein
V469_10995	COG3645	SOS response
V469_11020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
V469_11025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
V469_11040	COG2916	Histone family protein nucleoid-structuring protein H-NS
V469_11210	COG1643	Atp-dependent helicase
V469_11230	COG3437	response regulator, receiver
V469_11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V469_11240	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
V469_11245	COG0709	Synthesizes selenophosphate from selenide and ATP
V469_11270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V469_11275	COG0840	transmembrane signaling receptor activity
V469_11280	COG1254	Belongs to the acylphosphatase family
V469_11285	COG0625	glutathione transferase activity
V469_11290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V469_11290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V469_11295	COG0489	protein tyrosine kinase activity
V469_11300	COG0572	uridine kinase
V469_11305	COG0717	Belongs to the dCTP deaminase family
V469_11310	COG0306	phosphate transporter
V469_11315	COG1530	ribonuclease E activity
V469_11320	COG0564	pseudouridine synthase activity
V469_11330	COG0424	maF-like protein
V469_11335	COG2814	Major facilitator Superfamily
V469_11350	COG1399	metal-binding, possibly nucleic acid-binding protein
V469_11355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
V469_11360	COG0416	fatty acid biosynthetic process
V469_11365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V469_11375	COG1028	Short-chain dehydrogenase reductase Sdr
V469_11380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V469_11385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V469_11390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V469_11395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
V469_11400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
V469_11405	COG0470	DNA polymerase III
V469_11410	COG0084	hydrolase, TatD family'
V469_11425	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
V469_11425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V469_11430	COG3008	intermembrane lipid transfer
V469_11435	COG2995	paraquat-inducible protein a
V469_11445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
V469_11450	COG0372	Belongs to the citrate synthase family
V469_11495	COG4221	oxidoreductase activity
V469_11505	COG3141	response to X-ray
V469_11515	COG1067	ATP-dependent peptidase activity
V469_11520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V469_11535	COG0488	(ABC) transporter
V469_11545	COG0116	Belongs to the methyltransferase superfamily
V469_11545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V469_11555	COG0167	dihydroorotate dehydrogenase activity
V469_11560	COG2902	Dehydrogenase
V469_11570	COG0308	aminopeptidase N
V469_11580	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
V469_11585	COG1956	GAF domain-containing protein
V469_11595	COG3278	Belongs to the heme-copper respiratory oxidase family
V469_11610	COG2010	Cytochrome c
V469_11635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V469_11640	COG0589	response to stress
V469_11645	COG0037	tRNA processing
V469_11660	COG0625	glutathione transferase activity
V469_11665	COG1869	D-ribose catabolic process
V469_11670	COG1129	ABC transporter
V469_11675	COG1172	Belongs to the binding-protein-dependent transport system permease family
V469_11680	COG1879	ABC-type sugar transport system periplasmic component
V469_11685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V469_11690	COG1609	Transcriptional regulator
V469_11705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
V469_11725	COG0776	regulation of translation
V469_11730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V469_11730	COG0072	phenylalanine-tRNA ligase activity
V469_11735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
V469_11740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
V469_11745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
V469_11750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
V469_11755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
V469_11780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V469_11790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V469_11795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V469_11800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V469_11805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
V469_11810	COG3313	Fe-S protein
V469_11815	COG2942	2-epimerase
V469_11820	COG3716	PTS system mannose fructose sorbose family IID component
V469_11825	COG3715	PTS system
V469_11830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_11830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_11845	COG1609	Transcriptional regulator
V469_11850	COG2140	Oxalate decarboxylase
V469_11855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_11855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_11855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
V469_11860	COG1105	Belongs to the carbohydrate kinase PfkB family
V469_11865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_11865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_11870	COG1609	Transcriptional regulator
V469_11875	COG0814	amino acid
V469_11885	COG5654	RES domain protein
V469_11890	COG0513	Belongs to the DEAD box helicase family
V469_11900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
V469_11905	COG2890	protein-(glutamine-N5) methyltransferase activity
V469_11910	COG2840	Smr protein MutS2
V469_11920	COG3706	GGDEF domain
V469_11925	COG0588	phosphoglycerate mutase activity
V469_11955	COG2824	Alkylphosphonate utilization operon protein PhnA
V469_11975	COG0384	phenazine biosynthesis protein PhzF
V469_11990	COG0242	peptide deformylase activity
V469_12010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
V469_12015	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
V469_12025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V469_12030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V469_12040	COG0205	6-phosphofructokinase activity
V469_12045	COG1473	amidohydrolase
V469_12050	COG1011	Hydrolase
V469_12055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V469_12090	COG3593	DNA synthesis involved in DNA repair
V469_12105	COG0583	DNA-binding transcription factor activity
V469_12110	COG0730	response to heat
V469_12130	COG1181	Belongs to the D-alanine--D-alanine ligase family
V469_12140	COG0386	Belongs to the glutathione peroxidase family
V469_12145	COG0513	Belongs to the DEAD box helicase family
V469_12150	COG0456	acetyltransferase
V469_12160	COG1742	UPF0060 membrane protein
V469_12190	COG2329	Antibiotic biosynthesis monooxygenase
V469_12195	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
V469_12225	COG3243	poly(R)-hydroxyalkanoic acid synthase
V469_12235	COG2501	S4 domain
V469_12250	COG1132	(ABC) transporter
V469_12260	COG1132	(ABC) transporter
V469_12270	COG3118	belongs to the thioredoxin family
V469_12275	COG0471	metal ion transport
V469_12280	COG0058	SHG alpha-glucan phosphorylase activity
V469_12315	COG0814	amino acid
V469_12320	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
V469_12325	COG0514	ATP-dependent DNA helicase (RecQ)
V469_12330	COG2766	serine protein kinase
V469_12340	COG2719	SpoVR family
V469_12345	COG2186	Transcriptional regulator
V469_12350	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V469_12355	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
V469_12360	COG0586	Pfam SNARE associated Golgi protein
V469_12370	COG0556	nucleotide-excision repair
V469_12385	COG2985	domain, Protein
V469_12385	COG0569	domain protein
V469_12390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
V469_12410	COG4565	transcriptional regulatory protein
V469_12415	COG3290	protein histidine kinase activity
V469_12420	COG1846	Transcriptional regulator
V469_12420	COG1940	carbohydrate kinase activity
V469_12425	COG0840	transmembrane signaling receptor activity
V469_12430	COG3012	SEC-C Motif Domain Protein
V469_12435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V469_12440	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
V469_12445	COG0247	lactate metabolic process
V469_12465	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
V469_12470	COG0437	4 iron, 4 sulfur cluster binding
V469_12475	COG3301	Polysulphide reductase, NrfD
V469_12480	COG1138	Cytochrome C-type biogenesis protein
V469_12495	COG1051	belongs to the nudix hydrolase family
V469_12505	COG3033	Beta-eliminating lyase
V469_12510	COG3046	protein related to deoxyribodipyrimidine photolyase
V469_12515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V469_12540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
V469_12545	COG0583	DNA-binding transcription factor activity
V469_12555	COG4774	siderophore transport
V469_12560	COG4977	sequence-specific DNA binding
V469_12570	COG0583	DNA-binding transcription factor activity
V469_12575	COG2910	NAD(P)H-binding
V469_12585	COG0626	cystathionine gamma-synthase activity
V469_12590	COG0612	Peptidase, M16
V469_12595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V469_12600	COG2076	Multidrug Resistance protein
V469_12605	COG1944	ATP diphosphatase activity
V469_12610	COG2116	formate transmembrane transporter activity
V469_12615	COG1882	Formate acetyltransferase
V469_12620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V469_12630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V469_12640	COG1840	ABC-type Fe3 transport system, periplasmic component
V469_12645	COG3842	ATPase activity
V469_12655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V469_12660	COG2983	Belongs to the UPF0260 family
V469_12670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
V469_12675	COG0045	succinate-CoA ligase (ADP-forming) activity
V469_12680	COG0508	dehydrogenase complex catalyzes the overall conversion of
V469_12685	COG0567	Dehydrogenase, E1 component
V469_12695	COG1053	succinate dehydrogenase
V469_12700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
V469_12705	COG2009	succinate dehydrogenase
V469_12725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V469_12730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
V469_12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V469_12740	COG3069	C4-dicarboxylate transmembrane transporter activity
V469_12755	COG1451	nucleotide metabolic process
V469_12770	COG0254	rRNA binding
V469_12775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
V469_12785	COG0583	DNA-binding transcription factor activity
V469_12795	COG1172	Belongs to the binding-protein-dependent transport system permease family
V469_12805	COG1879	ABC-type sugar transport system periplasmic component
V469_12810	COG1069	ribulokinase activity
V469_12820	COG2160	L-arabinose isomerase activity
V469_12825	COG2925	Exonuclease
V469_12835	COG3345	alpha-galactosidase
V469_12840	COG1380	Effector of murein hydrolase LrgA
V469_12845	COG1346	cytolysis
V469_12850	COG0295	cytidine deaminase activity
V469_12855	COG1022	Amp-dependent synthetase and ligase
V469_12870	COG0861	Integral membrane protein TerC family
V469_12875	COG2885	chlorophyll binding
V469_12880	COG2199	diguanylate cyclase activity
V469_12895	COG2154	pterin-4-alpha-carbinolamine dehydratase
V469_12900	COG2154	pterin-4-alpha-carbinolamine dehydratase
V469_12910	COG3768	UPF0283 membrane protein
V469_12915	COG3106	COG3106 Predicted ATPase
V469_12930	COG1842	Phage shock protein A
V469_12935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
V469_12945	COG4168	peptide transport system, permease
V469_12950	COG4171	peptide transport system, permease
V469_12965	COG4172	Belongs to the ABC transporter superfamily
V469_12975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
V469_12980	COG1286	toxin biosynthetic process
V469_12985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
V469_12995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
V469_13000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
V469_13005	COG1674	ftsk spoiiie
V469_13005	COG0531	amino acid
V469_13015	COG0492	ferredoxin-NADP+ reductase activity
V469_13020	COG3706	GGDEF domain
V469_13025	COG3134	Outer membrane lipoprotein
V469_13030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
V469_13035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
V469_13040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
V469_13045	COG0542	response to heat
V469_13050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
V469_13055	COG1278	Cold shock
V469_13060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
V469_13085	COG3179	chitinase
V469_13090	COG3501	Rhs element vgr protein
V469_13195	COG3501	Rhs element vgr protein
V469_13225	COG1435	thymidine kinase activity
V469_13230	COG1757	Na H antiporter
V469_13235	COG2916	Histone family protein nucleoid-structuring protein H-NS
V469_13240	COG2096	Adenosyltransferase
V469_13245	COG3530	Putative quorum-sensing-regulated virulence factor
V469_13250	COG0602	queuosine metabolic process
V469_13255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
V469_13275	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
V469_13285	COG0776	regulation of translation
V469_13290	COG0539	negative regulation of cytoplasmic translation
V469_13295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
V469_13300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V469_13310	COG0583	DNA-binding transcription factor activity
V469_13330	COG0778	Nitroreductase
V469_13335	COG5001	Diguanylate cyclase
V469_13335	COG3300	MHYT domain
V469_13345	COG0583	DNA-binding transcription factor activity
V469_13350	COG3437	response regulator, receiver
V469_13375	COG4989	oxidoreductase activity
V469_13380	COG0724	RNA recognition motif
V469_13400	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
V469_13415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V469_13420	COG1360	Flagellar Motor Protein
V469_13425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_13430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_13435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_13435	COG0649	NAD binding
V469_13450	COG1034	ATP synthesis coupled electron transport
V469_13455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
V469_13460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_13465	COG0839	Belongs to the complex I subunit 6 family
V469_13470	COG0713	ATP synthesis coupled electron transport
V469_13480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V469_13485	COG1007	ATP synthesis coupled electron transport
V469_13495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
V469_13495	COG0047	phosphoribosylformylglycinamidine synthase activity
V469_13500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
V469_13505	COG1645	bacterial-type flagellum-dependent swarming motility
V469_13510	COG1160	GTP binding
V469_13515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V469_13520	COG2976	Protein conserved in bacteria
V469_13525	COG0124	histidyl-tRNA synthetase
V469_13530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
V469_13545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
V469_13550	COG0105	UTP biosynthetic process
V469_13555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V469_13565	COG0633	Ferredoxin
V469_13570	COG0443	Heat shock 70 kDa protein
V469_13575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V469_13585	COG0822	iron-sulfur transferase activity
V469_13590	COG1104	cysteine desulfurase activity
V469_13635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V469_13640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V469_13645	COG1862	Preprotein translocase
V469_13650	COG0343	queuine tRNA-ribosyltransferase activity
V469_13655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
V469_13660	COG0517	IMP dehydrogenase activity
V469_13665	COG0450	alkyl hydroperoxide reductase
V469_13670	COG3634	alkyl hydroperoxide reductase activity
V469_13675	COG2814	Major facilitator Superfamily
V469_13690	COG1393	Belongs to the ArsC family
V469_13695	COG0798	PFAM Bile acid sodium symporter
V469_13700	COG0640	Transcriptional regulator
V469_13705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V469_13705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V469_13710	COG0509	glycine decarboxylation via glycine cleavage system
V469_13715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
V469_13720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V469_13725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V469_13740	COG2814	Major facilitator Superfamily
V469_13745	COG0625	glutathione transferase activity
V469_13755	COG0483	inositol monophosphate 1-phosphatase activity
V469_13775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
V469_13790	COG1086	Polysaccharide biosynthesis protein
V469_13810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
V469_13900	COG0301	tRNA thio-modification
V469_13900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V469_13910	COG4953	penicillin-binding protein 1C
V469_13915	COG2373	Large extracellular alpha-helical protein
V469_13920	COG1473	amidohydrolase
V469_13925	COG0628	permease
V469_13930	COG1538	Outer membrane efflux protein
V469_13935	COG1566	PFAM secretion protein HlyD family protein
V469_13950	COG0446	pyridine nucleotide-disulphide oxidoreductase
V469_13960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V469_13975	COG4215	(ABC) transporter
V469_13980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_13990	COG2431	L-lysine efflux transmembrane transporter activity
V469_13995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V469_14000	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
V469_14020	COG1393	Belongs to the ArsC family
V469_14030	COG4783	chaperone-mediated protein folding
V469_14060	COG3842	ATPase activity
V469_14070	COG1175	transmembrane transport
V469_14080	COG3081	Nucleoid-associated protein
V469_14085	COG3082	Protein of unknown function (DUF1414)
V469_14090	COG3083	sulfuric ester hydrolase activity
V469_14095	COG4771	TonB-dependent receptor
V469_14100	COG1770	oligopeptidase
V469_14120	COG4574	serine-type endopeptidase inhibitor activity
V469_14125	COG3085	chromosome segregation
V469_14130	COG0583	DNA-binding transcription factor activity
V469_14135	COG0287	Prephenate dehydrogenase
V469_14135	COG1605	Chorismate mutase
V469_14140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V469_14145	COG0584	glycerophosphoryl diester phosphodiesterase
V469_14155	COG1349	DNA-binding transcription factor activity
V469_14160	COG2271	Major facilitator Superfamily
V469_14165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
V469_14170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
V469_14175	COG0583	DNA-binding transcription factor activity
V469_14195	COG0656	L-ascorbic acid biosynthetic process
V469_14200	COG2814	Major facilitator Superfamily
V469_14210	COG1294	oxidase, subunit
V469_14220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V469_14230	COG2979	Protein of unknown function (DUF533)
V469_14255	COG2271	Major facilitator Superfamily
V469_14260	COG0583	DNA-binding transcription factor activity
V469_14270	COG2807	transmembrane transport
V469_14275	COG1187	pseudouridine synthase activity
V469_14305	COG1061	Type III restriction enzyme res subunit
V469_14315	COG2964	Protein conserved in bacteria
V469_14320	COG3681	Belongs to the UPF0597 family
V469_14330	COG0814	amino acid
V469_14350	COG1166	arginine decarboxylase activity
V469_14355	COG2195	Cleaves the N-terminal amino acid of tripeptides
V469_14385	COG0583	DNA-binding transcription factor activity
V469_14395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
V469_14400	COG0840	transmembrane signaling receptor activity
V469_14405	COG0302	gtp cyclohydrolase
V469_14415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V469_14420	COG2267	carboxylic ester hydrolase activity
V469_14425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
V469_14440	COG0314	molybdopterin synthase activity
V469_14445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
V469_14450	COG0315	cyclic pyranopterin monophosphate synthase activity
V469_14455	COG0521	Mo-molybdopterin cofactor biosynthetic process
V469_14460	COG3005	denitrification pathway
V469_14470	COG0348	domain, Protein
V469_14475	COG0437	4 iron, 4 sulfur cluster binding
V469_14480	COG0243	molybdopterin cofactor binding
V469_14495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_14495	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_14500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
V469_14505	COG3850	Histidine kinase
V469_14510	COG2197	response regulator
V469_14540	COG0121	glutamine amidotransferase
V469_14545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V469_14555	COG1960	acyl-CoA dehydrogenase activity
V469_14565	COG0784	Response regulator, receiver
V469_14565	COG3437	response regulator, receiver
V469_14575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V469_14580	COG0328	RNA-DNA hybrid ribonuclease activity
V469_14585	COG2226	methyltransferase
V469_14590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V469_14595	COG1388	LysM domain
V469_14595	COG0741	lytic transglycosylase activity
V469_14600	COG3021	interspecies interaction between organisms
V469_14610	COG1607	acyl-coa hydrolase
V469_14625	COG0741	lytic transglycosylase activity
V469_14635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V469_14660	COG0729	surface antigen
V469_14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V469_14675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V469_14685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
V469_14695	COG4134	Bacterial extracellular solute-binding protein
V469_14705	COG4136	ATPase activity
V469_14710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
V469_14715	COG2951	lytic endotransglycosylase activity
V469_14720	COG1846	Transcriptional regulator
V469_14730	COG0033	Phosphoglucomutase
V469_14735	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
V469_14740	COG0596	Alpha beta hydrolase
V469_14755	COG0716	FMN binding
V469_14765	COG0735	belongs to the Fur family
V469_14770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V469_14780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_14780	COG1263	PTS System
V469_14780	COG2190	(PTS) system
V469_14785	COG0363	glucosamine-6-phosphate deaminase activity
V469_14790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V469_14795	COG1846	Transcriptional regulator
V469_14795	COG1940	carbohydrate kinase activity
V469_14805	COG2194	sulfuric ester hydrolase activity
V469_14810	COG0217	transcriptional regulatory protein
V469_14815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
V469_14820	COG1801	Protein of unknown function DUF72
V469_14825	COG4106	trans-aconitate 2-methyltransferase activity
V469_14830	COG0500	methyltransferase
V469_14850	COG0450	alkyl hydroperoxide reductase
V469_14855	COG0583	DNA-binding transcription factor activity
V469_14865	COG0791	NLP P60 protein
V469_14880	COG1309	transcriptional regulator
V469_14920	COG0534	Mate efflux family protein
V469_14940	COG2366	antibiotic biosynthetic process
V469_14945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
V469_14945	COG1013	pyruvate-flavodoxin oxidoreductase activity
V469_14945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
V469_14945	COG0674	pyruvate-flavodoxin oxidoreductase activity
V469_14955	COG0633	Ferredoxin
V469_14955	COG0633	Ferredoxin
V469_14955	COG3217	Mosc domain protein beta barrel domain protein
V469_14955	COG3217	Mosc domain protein beta barrel domain protein
V469_14965	COG0501	Belongs to the peptidase M48B family
V469_14970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
V469_14975	COG1073	alpha beta
V469_14975	COG2226	methyltransferase
V469_14980	COG0156	8-amino-7-oxononanoate synthase activity
V469_14985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V469_15005	COG0017	Asparaginyl-tRNA synthetase
V469_15010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V469_15025	COG3069	C4-dicarboxylate transmembrane transporter activity
V469_15035	COG0583	DNA-binding transcription factor activity
V469_15040	COG1393	Belongs to the ArsC family
V469_15045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V469_15050	COG1876	peptidase activity
V469_15080	COG1280	lysine exporter protein (LysE YggA)
V469_15105	COG1957	nucleoside hydrolase
V469_15110	COG0564	pseudouridine synthase activity
V469_15120	COG1454	alcohol dehydrogenase
V469_15170	COG4964	Belongs to the GSP D family
V469_15200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V469_15205	COG0702	epimerase
V469_15215	COG2867	negative regulation of translational initiation
V469_15220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
V469_15300	COG4397	Mu-like prophage major head subunit gpT
V469_15305	COG4388	Caudovirus prohead serine protease
V469_15325	COG4383	Mu-like prophage protein gp29
V469_15330	COG4373	Mu-like prophage FluMu protein gp28
V469_15340	COG0640	Transcriptional regulator
V469_15380	COG5566	PFAM Mor transcription activator
V469_15485	COG0583	DNA-binding transcription factor activity
V469_15490	COG2610	gluconate transmembrane transporter activity
V469_15495	COG3048	D-serine ammonia-lyase activity
V469_15505	COG0538	isocitrate dehydrogenase activity
V469_15510	COG2207	Transcriptional regulator
V469_15530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_15540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
V469_15545	COG1263	PTS System
V469_15545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_15550	COG1609	Transcriptional regulator
V469_15565	COG0456	acetyltransferase
V469_15585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_15585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_15585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_15595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V469_15605	COG1187	pseudouridine synthase activity
V469_15615	COG0482	sulfurtransferase activity
V469_15620	COG2915	High frequency lysogenization protein hflD homolog
V469_15625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
V469_15630	COG2850	peptidyl-arginine hydroxylation
V469_15640	COG3153	acetyltransferase
V469_15650	COG0625	glutathione transferase activity
V469_15655	COG0259	pyridoxamine-phosphate oxidase activity
V469_15670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V469_15670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V469_15675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
V469_15690	COG3088	subunit of a heme lyase
V469_15690	COG4235	cytochrome complex assembly
V469_15695	COG3088	subunit of a heme lyase
V469_15695	COG4235	cytochrome complex assembly
V469_15700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
V469_15705	COG1138	Cytochrome C-type biogenesis protein
V469_15710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
V469_15715	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V469_15720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V469_15725	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V469_15740	COG0835	chemotaxis
V469_15750	COG1192	Involved in chromosome partitioning
V469_15755	COG1360	Flagellar Motor Protein
V469_15760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V469_15765	COG2201	protein-glutamate methylesterase activity
V469_15770	COG2198	Histidine kinase
V469_15770	COG0643	Histidine kinase
V469_15775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
V469_15790	COG0455	bacterial-type flagellum organization
V469_15800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
V469_15810	COG1684	flagellar biosynthetic protein fliR
V469_15815	COG1987	bacterial-type flagellum assembly
V469_15865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
V469_15875	COG1677	Flagellar hook-basal body complex protein FliE
V469_15890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V469_15900	COG1073	alpha beta
V469_15900	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
V469_15900	COG3064	Membrane
V469_15915	COG2274	protein secretion by the type I secretion system
V469_15925	COG2274	protein secretion by the type I secretion system
V469_15930	COG0745	RESPONSE REGULATOR receiver
V469_15945	COG1737	Transcriptional regulator
V469_15950	COG0469	pyruvate kinase activity
V469_15960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V469_15965	COG1960	acyl-CoA dehydrogenase activity
V469_15975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
V469_15985	COG0243	molybdopterin cofactor binding
V469_15990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
V469_15995	COG0583	DNA-binding transcription factor activity
V469_16015	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
V469_16020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
V469_16025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
V469_16030	COG1454	alcohol dehydrogenase
V469_16030	COG1012	belongs to the aldehyde dehydrogenase family
V469_16040	COG1012	belongs to the aldehyde dehydrogenase family
V469_16040	COG1454	alcohol dehydrogenase
V469_16045	COG1882	Formate acetyltransferase
V469_16050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V469_16055	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
V469_16060	COG4869	propanediol catabolic process
V469_16105	COG2731	YhcH YjgK YiaL family protein
V469_16110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V469_16120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
V469_16125	COG1737	Transcriptional regulator
V469_16130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
V469_16135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
V469_16140	COG1349	DNA-binding transcription factor activity
V469_16145	COG0738	Major facilitator superfamily
V469_16155	COG1070	Carbohydrate kinase
V469_16175	COG4172	Belongs to the ABC transporter superfamily
V469_16180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V469_16190	COG0747	negative chemotaxis
V469_16200	COG1376	ErfK ybiS ycfS ynhG family protein
V469_16200	COG1388	LysM domain
V469_16215	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
V469_16220	COG0791	NLP P60 protein
V469_16225	COG2091	lysine biosynthetic process via aminoadipic acid
V469_16230	COG3118	belongs to the thioredoxin family
V469_16240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V469_16245	COG0788	formyltetrahydrofolate deformylase activity
V469_16255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V469_16275	COG0366	Alpha amylase catalytic
V469_16280	COG1196	nuclear chromosome segregation
V469_16280	COG0741	lytic transglycosylase activity
V469_16280	COG0739	heme binding
V469_16285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
V469_16290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
V469_16300	COG0673	inositol 2-dehydrogenase activity
V469_16320	COG1032	radical SAM domain protein
V469_16330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V469_16335	COG1566	PFAM secretion protein HlyD family protein
V469_16340	COG2203	Gaf domain
V469_16340	COG2199	diguanylate cyclase activity
V469_16345	COG1752	Esterase of the alpha-beta hydrolase superfamily
V469_16350	COG0733	neurotransmitter:sodium symporter activity
V469_16380	COG0281	malic enzyme
V469_16390	COG0534	Mate efflux family protein
V469_16400	COG0745	RESPONSE REGULATOR receiver
V469_16400	COG3706	GGDEF domain
V469_16405	COG2233	PERMEase
V469_16410	COG0095	Lipoate-protein ligase
V469_16415	COG1115	amino acid carrier protein
V469_16420	COG0019	diaminopimelate decarboxylase activity
V469_16430	COG0678	peroxiredoxin activity
V469_16440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
V469_16460	COG1131	(ABC) transporter
V469_16465	COG0545	Peptidyl-prolyl cis-trans isomerase
V469_16470	COG3142	Participates in the control of copper homeostasis
V469_16485	COG4783	chaperone-mediated protein folding
V469_16495	COG5002	protein histidine kinase activity
V469_16500	COG0745	RESPONSE REGULATOR receiver
V469_16505	COG0346	lactoylglutathione lyase activity
V469_16510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
V469_16515	COG1960	acyl-CoA dehydrogenase activity
V469_16520	COG3284	Transcriptional regulator
V469_16525	COG1012	belongs to the aldehyde dehydrogenase family
V469_16535	COG0697	spore germination
V469_16540	COG4565	transcriptional regulatory protein
V469_16545	COG3290	protein histidine kinase activity
V469_16550	COG0281	malic enzyme
V469_16565	COG1846	Transcriptional regulator
V469_16570	COG1566	PFAM secretion protein HlyD family protein
V469_16600	COG0602	queuosine metabolic process
V469_16605	COG1328	CTP reductase activity
V469_16615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
V469_16620	COG3115	cell septum assembly
V469_16625	COG1196	nuclear chromosome segregation
V469_16635	COG2860	membrane
V469_16645	COG3108	Peptidase M15
V469_16650	COG2989	Protein conserved in bacteria
V469_16665	COG0463	Glycosyl transferase, family 2
V469_16680	COG0366	Alpha amylase catalytic
V469_16715	COG3706	GGDEF domain
V469_16720	COG0037	tRNA processing
V469_16725	COG3590	peptidase
V469_16735	COG0488	(ABC) transporter
V469_16745	COG0531	amino acid
V469_16760	COG0814	amino acid
V469_16775	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
V469_16780	COG1982	Orn Lys Arg decarboxylase major
V469_16785	COG0531	amino acid
V469_16790	COG3710	Transcriptional regulator
V469_16795	COG0825	malonyl-CoA metabolic process
V469_16805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
V469_16810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V469_16815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V469_16820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V469_16825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V469_16840	COG0750	zinc metalloprotease
V469_16850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
V469_16855	COG0575	Belongs to the CDS family
V469_16865	COG0233	cytoplasmic translational termination
V469_16870	COG0528	UMP kinase activity
V469_16875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
V469_16880	COG0052	Belongs to the universal ribosomal protein uS2 family
V469_16885	COG0024	Methionine aminopeptidase
V469_16890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
V469_16895	COG2171	N-acyltransferase activity
V469_16905	COG1263	PTS System
V469_16905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_16915	COG4580	involved in the transport of maltose and maltodextrins
V469_16925	COG0564	pseudouridine synthase activity
V469_16930	COG3098	single-species biofilm formation
V469_16955	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
V469_16965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V469_16965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V469_16975	COG3706	GGDEF domain
V469_16980	COG1611	Belongs to the LOG family
V469_16985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V469_16990	COG0473	3-isopropylmalate dehydrogenase activity
V469_17000	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
V469_17005	COG2363	Small membrane protein
V469_17015	COG0583	DNA-binding transcription factor activity
V469_17020	COG0840	transmembrane signaling receptor activity
V469_17025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
V469_17040	COG1477	protein flavinylation
V469_17045	COG2871	sodium ion transport
V469_17050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V469_17055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V469_17060	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V469_17065	COG1805	sodium ion transport
V469_17070	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V469_17075	COG0271	Belongs to the BolA IbaG family
V469_17080	COG2813	Specifically methylates the guanine in position
V469_17090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V469_17100	COG2211	Major facilitator Superfamily
V469_17105	COG3248	Nucleoside-binding outer membrane protein
V469_17110	COG1666	GTP binding
V469_17115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
V469_17120	COG0693	protein deglycase activity
V469_17155	COG3501	Rhs element vgr protein
V469_17165	COG2771	luxR family
V469_17175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V469_17175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V469_17180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
V469_17190	COG1151	hydroxylamine reductase activity
V469_17195	COG0783	Belongs to the Dps family
V469_17220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V469_17235	COG4221	oxidoreductase activity
V469_17245	COG0415	Belongs to the DNA photolyase family
V469_17250	COG0789	Transcriptional regulator
V469_17255	COG3272	Protein of unknown function (DUF1722)
V469_17285	COG0077	Prephenate dehydratase
V469_17285	COG1605	Chorismate mutase
V469_17315	COG5377	YqaJ viral recombinase family
V469_17360	COG2003	Belongs to the UPF0758 family
V469_17370	COG0602	queuosine metabolic process
V469_17375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
V469_17415	COG0514	ATP-dependent DNA helicase (RecQ)
V469_17420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V469_17445	COG4771	TonB-dependent receptor
V469_17465	COG1116	anion transmembrane transporter activity
V469_17505	COG2226	methyltransferase
V469_17540	COG2133	pyrroloquinoline quinone binding
V469_17550	COG0840	transmembrane signaling receptor activity
V469_17560	COG0300	oxidoreductase activity
V469_17585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
V469_17600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
V469_17605	COG0826	peptidase U32
V469_17610	COG1280	lysine exporter protein (LysE YggA)
V469_17625	COG0840	transmembrane signaling receptor activity
V469_17630	COG0745	RESPONSE REGULATOR receiver
V469_17640	COG0643	Histidine kinase
V469_17640	COG2198	Histidine kinase
V469_17650	COG0835	chemotaxis
V469_17655	COG0840	transmembrane signaling receptor activity
V469_17665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
V469_17670	COG2201	protein-glutamate methylesterase activity
V469_17675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V469_17705	COG2203	Gaf domain
V469_17705	COG2200	EAL domain
V469_17705	COG2199	diguanylate cyclase activity
V469_17715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V469_17725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V469_17730	COG0305	Participates in initiation and elongation during chromosome replication
V469_17745	COG2200	EAL domain
V469_17750	COG0737	Belongs to the 5'-nucleotidase family
V469_17770	COG2204	response regulator
V469_17775	COG0545	Peptidyl-prolyl cis-trans isomerase
V469_17785	COG2900	Belongs to the SlyX family
V469_17790	COG1047	Peptidyl-prolyl cis-trans
V469_17795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
V469_17805	COG0784	Response regulator, receiver
V469_17805	COG0835	chemotaxis
V469_17810	COG0429	hydrolase of the alpha beta-hydrolase fold
V469_17815	COG2203	Gaf domain
V469_17815	COG3706	GGDEF domain
V469_17815	COG4251	negative regulation of phosphorylation
V469_17815	COG5001	Diguanylate cyclase
V469_17820	COG3089	Belongs to the UPF0270 family
V469_17830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
V469_17835	COG0463	Glycosyl transferase, family 2
V469_17840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V469_17840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
V469_17845	COG0726	polysaccharide deacetylase
V469_17850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
V469_17855	COG2076	Multidrug Resistance protein
V469_17860	COG2076	Multidrug Resistance protein
V469_17865	COG3954	Phosphoribulokinase
V469_17880	COG1765	OsmC-like protein
V469_17885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V469_17890	COG2226	methyltransferase
V469_17895	COG3397	chitin binding
V469_17910	COG2202	Pas domain
V469_17910	COG2205	protein histidine kinase activity
V469_17920	COG3655	Transcriptional regulator
V469_17925	COG2814	Major facilitator Superfamily
V469_17930	COG4771	TonB-dependent receptor
V469_17950	COG0748	coenzyme F420 binding
V469_17955	COG3721	Heme iron utilization protein
V469_17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V469_17990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
V469_17995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V469_18000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
V469_18020	COG0741	lytic transglycosylase activity
V469_18025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
V469_18125	COG0616	signal peptide processing
V469_18140	COG4626	Terminase
V469_18140	COG1802	Transcriptional regulator
V469_18185	COG0464	growth
V469_18320	COG0582	viral genome integration into host DNA
V469_18325	COG0488	(ABC) transporter
V469_18335	COG2252	PERMEase
V469_18340	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V469_18345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
V469_18355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
V469_18365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
V469_18370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
V469_18380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
V469_18390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
V469_18410	COG0318	PFAM AMP-dependent synthetase and ligase
V469_18420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
V469_18425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
V469_18430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
V469_18435	COG0142	geranyltranstransferase activity
V469_18440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
V469_18445	COG0330	HflC and HflK could
V469_18450	COG0330	HflC and HflK could
V469_18455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
V469_18460	COG1923	regulation of RNA biosynthetic process
V469_18465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
V469_18470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
V469_18485	COG0802	atpase or kinase
V469_18490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
V469_18490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
V469_18510	COG5002	protein histidine kinase activity
V469_18510	COG2198	Histidine kinase
V469_18510	COG0784	Response regulator, receiver
V469_18530	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V469_18545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
V469_18550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
V469_18560	COG2716	regulation of RNA biosynthetic process
V469_18565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
V469_18570	COG3013	Belongs to the UPF0304 family
V469_18575	COG3092	negative regulation of chromosome organization
V469_18580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V469_18585	COG0857	belongs to the CobB CobQ family
V469_18585	COG0280	phosphate acetyltransferase
V469_18595	COG0028	Belongs to the TPP enzyme family
V469_18610	COG0671	phosphoesterase, PA-phosphatase related
V469_18620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
V469_18625	COG0473	3-isopropylmalate dehydrogenase activity
V469_18630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
V469_18635	COG0066	3-isopropylmalate dehydratase activity
V469_18650	COG4143	(ABC) transporter
V469_18655	COG1178	ABC-type Fe3 transport system permease component
V469_18660	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
V469_18665	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
V469_18675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V469_18710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V469_18715	COG0564	pseudouridine synthase activity
V469_18725	COG3300	MHYT domain
V469_18725	COG5001	Diguanylate cyclase
V469_18735	COG0459	protein refolding
V469_18740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V469_18745	COG0534	Mate efflux family protein
V469_18750	COG3030	protein affecting phage T7 exclusion by the F plasmid
V469_18755	COG1027	Aspartate ammonia-lyase
V469_18760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V469_18770	COG0477	Major facilitator Superfamily
V469_18795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V469_18805	COG0673	inositol 2-dehydrogenase activity
V469_18815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
V469_18820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V469_18825	COG3036	rescue of stalled ribosome
V469_18830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
V469_18840	COG0138	bifunctional purine biosynthesis protein purh
V469_18845	COG0151	Belongs to the GarS family
V469_18875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V469_18880	COG0358	DNA primase activity
V469_18885	COG1610	YqeY-like protein
V469_18890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
V469_18895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
V469_18905	COG1388	LysM domain
V469_18905	COG4942	peptidase
V469_18910	COG1238	metal cluster binding
V469_18915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
V469_18920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
V469_18925	COG0585	pseudouridine synthase activity
V469_18935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
V469_18940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
V469_18945	COG0148	phosphopyruvate hydratase activity
V469_18950	COG0504	CTP synthase activity
V469_18955	COG3956	TIGRFAM MazG family protein
V469_18960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V469_18965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V469_18975	COG4807	Protein conserved in bacteria
V469_18980	COG3023	N-Acetylmuramoyl-L-alanine amidase
V469_18985	COG1349	DNA-binding transcription factor activity
V469_18995	COG2222	sugar isomerase
V469_19000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_19010	COG3716	PTS system mannose fructose sorbose family IID component
V469_19015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_19020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V469_19035	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
V469_19040	COG1381	Involved in DNA repair and RecF pathway recombination
V469_19050	COG0571	ribonuclease III activity
V469_19055	COG0681	Belongs to the peptidase S26 family
V469_19060	COG0481	GTPase activity
V469_19080	COG1595	DNA-templated transcription, initiation
V469_19085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
V469_19095	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
V469_19100	COG0354	folic acid binding
V469_19135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V469_19140	COG0191	fructose-bisphosphate aldolase activity
V469_19145	COG0126	phosphoglycerate kinase activity
V469_19150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V469_19155	COG1940	carbohydrate kinase activity
V469_19160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
V469_19175	COG4991	sh3 domain protein
V469_19180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V469_19195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V469_19215	COG1505	serine-type exopeptidase activity
V469_19220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
V469_19225	COG0765	amino acid transport
V469_19230	COG0765	amino acid transport
V469_19235	COG1126	abc transporter atp-binding protein
V469_19240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_19245	COG0577	efflux transmembrane transporter activity
V469_19245	COG1136	(ABC) transporter
V469_19250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V469_19255	COG0745	RESPONSE REGULATOR receiver
V469_19260	COG2205	protein histidine kinase activity
V469_19300	COG2070	2-Nitropropane dioxygenase
V469_19325	COG1858	cytochrome C peroxidase
V469_19330	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
V469_19350	COG0513	Belongs to the DEAD box helicase family
V469_19380	COG0154	amidase activity
V469_19385	COG2957	Belongs to the agmatine deiminase family
V469_19400	COG1902	pentaerythritol trinitrate reductase activity
V469_19430	COG3706	GGDEF domain
V469_19430	COG0745	RESPONSE REGULATOR receiver
V469_19435	COG5001	Diguanylate cyclase
V469_19445	COG0714	Associated with various cellular activities
V469_19455	COG0456	acetyltransferase
V469_19465	COG1022	Amp-dependent synthetase and ligase
V469_19475	COG2918	glutathione biosynthetic process
V469_19480	COG0612	Peptidase, M16
V469_19485	COG1238	metal cluster binding
V469_19510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V469_19515	COG0359	binds to the 23S rRNA
V469_19520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
V469_19525	COG0360	Binds together with S18 to 16S ribosomal RNA
V469_19530	COG1914	H( )-stimulated, divalent metal cation uptake system
V469_19550	COG2153	protein acetylation
V469_19560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V469_19565	COG0557	exoribonuclease II activity
V469_19570	COG3706	GGDEF domain
V469_19575	COG1854	S-ribosylhomocysteine lyase activity
V469_19590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
V469_19590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
V469_19650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
V469_19655	COG1047	Peptidyl-prolyl cis-trans
V469_19660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
V469_19665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
V469_19670	COG0196	riboflavin kinase activity
V469_19675	COG0728	peptidoglycan biosynthetic process
V469_19680	COG0268	Binds directly to 16S ribosomal RNA
V469_19685	COG0640	Transcriptional regulator
V469_19690	COG0583	DNA-binding transcription factor activity
V469_19700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V469_19705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
V469_19710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
V469_19720	COG1051	belongs to the nudix hydrolase family
V469_19725	COG3066	DNA modification
V469_19735	COG0335	large ribosomal subunit rRNA binding
V469_19740	COG0336	Belongs to the RNA methyltransferase TrmD family
V469_19745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
V469_19750	COG0228	four-way junction DNA binding
V469_19755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
V469_19760	COG4137	Cytochrome C assembly protein
V469_19765	COG4536	flavin adenine dinucleotide binding
V469_19775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V469_19775	COG1017	nitric oxide dioxygenase activity
V469_19780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
V469_19785	COG0039	L-malate dehydrogenase activity
V469_19790	COG4160	amino acid transport
V469_19795	COG4215	(ABC) transporter
V469_19800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V469_19805	COG1126	abc transporter atp-binding protein
V469_19810	COG1438	arginine binding
V469_19815	COG2837	iron assimilation
V469_19820	COG3842	ATPase activity
V469_19830	COG1840	ABC-type Fe3 transport system, periplasmic component
V469_19835	COG0347	Belongs to the P(II) protein family
V469_19850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V469_19855	COG0583	DNA-binding transcription factor activity
V469_19870	COG1929	Belongs to the glycerate kinase type-1 family
V469_19875	COG2610	gluconate transmembrane transporter activity
V469_19880	COG3835	regulator
V469_19890	COG3112	Uncharacterised protein family (UPF0231)
V469_19905	COG0840	transmembrane signaling receptor activity
V469_19910	COG3568	Endonuclease Exonuclease Phosphatase
V469_19925	COG0513	Belongs to the DEAD box helicase family
V469_19965	COG1448	Aminotransferase
V469_19980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V469_19985	COG1328	CTP reductase activity
V469_20005	COG0793	Belongs to the peptidase S41A family
V469_20005	COG4946	Tricorn protease homolog
V469_20035	COG0840	transmembrane signaling receptor activity
V469_20040	COG3397	chitin binding
V469_20045	COG0583	DNA-binding transcription factor activity
V469_20055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
V469_20060	COG4208	sulfate ABC transporter
V469_20065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
V469_20075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
V469_20080	COG3174	membrane
V469_20085	COG0110	maltose O-acetyltransferase activity
V469_20110	COG0165	Argininosuccinate lyase
V469_20115	COG0137	argininosuccinate synthase activity
V469_20125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V469_20130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
V469_20140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
V469_20150	COG0460	homoserine dehydrogenase
V469_20150	COG0527	aspartate kinase activity
V469_20155	COG0626	cystathionine gamma-synthase activity
V469_20165	COG3708	Transcriptional regulator
V469_20165	COG2207	Transcriptional regulator
V469_20170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V469_20175	COG0814	amino acid
V469_20180	COG1218	3'(2'),5'-bisphosphate nucleotidase
V469_20185	COG0494	nUDIX hydrolase
V469_20190	COG1011	Hydrolase
V469_20195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V469_20210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V469_20220	COG3156	type II secretion system protein K
V469_20225	COG4795	General secretion pathway protein
V469_20230	COG2165	general secretion pathway protein
V469_20245	COG2165	general secretion pathway protein
V469_20250	COG1459	type II secretion system
V469_20255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V469_20265	COG3031	protein transport across the cell outer membrane
V469_20275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
V469_20300	COG0456	acetyltransferase
V469_20305	COG3133	Outer membrane lipoprotein
V469_20325	COG3916	Acyl-homoserine-lactone synthase
V469_20335	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
V469_20340	COG1309	transcriptional regulator
V469_20355	COG2213	PTS system mannitol-specific
V469_20355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V469_20360	COG0246	Mannitol dehydrogenase
V469_20365	COG3722	fumarate hydratase activity
V469_20370	COG3263	regulation of cellular component size
V469_20410	COG1988	membrane-bound metal-dependent
V469_20415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V469_20420	COG0513	Belongs to the DEAD box helicase family
V469_20445	COG1575	Belongs to the MenA family. Type 1 subfamily
V469_20450	COG1169	isochorismate synthase
V469_20455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
V469_20460	COG0596	Alpha beta hydrolase
V469_20465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
V469_20470	COG1441	menaquinone biosynthetic process
V469_20475	COG0318	PFAM AMP-dependent synthetase and ligase
V469_20490	COG3539	Fimbrial protein
V469_20495	COG3121	Chaperone
V469_20500	COG3188	usher protein
V469_20510	COG3539	Fimbrial protein
V469_20520	COG3291	Pkd domain containing protein
V469_20525	COG2949	membrane
V469_20540	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
V469_20545	COG5380	lipid catabolic process
V469_20560	COG4533	DNA binding
V469_20570	COG2873	o-acetylhomoserine
V469_20580	COG1979	alcohol dehydrogenase
V469_20600	COG4221	oxidoreductase activity
V469_20620	COG1285	pathogenesis
V469_20640	COG1368	sulfuric ester hydrolase activity
V469_20645	COG1522	sequence-specific DNA binding
V469_20655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
V469_20660	COG1418	mRNA catabolic process
V469_20665	COG1546	Belongs to the CinA family
V469_20665	COG1058	Belongs to the CinA family
V469_20680	COG1129	ABC transporter
V469_20680	COG0842	Transport permease protein
V469_20695	COG0561	phosphatase activity
V469_20700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
V469_20720	COG1011	Hydrolase
V469_20735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
V469_20740	COG0019	diaminopimelate decarboxylase activity
V469_20745	COG1965	Belongs to the frataxin family
V469_20750	COG0400	carboxylic ester hydrolase activity
V469_20755	COG3072	Adenylate cyclase
V469_20760	COG0181	hydroxymethylbilane synthase activity
V469_20770	COG2959	enzyme of heme biosynthesis
V469_20785	COG1494	fructose-1,6-bisphosphatase
V469_20825	COG1733	regulation of RNA biosynthetic process
V469_20845	COG3932	Exopolysaccharide synthesis, ExoD
V469_20850	COG0814	amino acid
V469_20855	COG3706	GGDEF domain
V469_20870	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
V469_20885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V469_20890	COG2022	thiamine diphosphate biosynthetic process
V469_20900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V469_20905	COG0352	thiamine-phosphate diphosphorylase activity
V469_20910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
V469_20930	COG0745	RESPONSE REGULATOR receiver
V469_20940	COG1114	Component of the transport system for branched-chain amino acids
V469_20945	COG0189	ligase activity
V469_20990	COG3171	Protein conserved in bacteria
V469_21005	COG3188	usher protein
V469_21060	COG1639	'signal transduction protein
V469_21070	COG2321	neutral zinc metallopeptidase
V469_21075	COG3700	Belongs to the class B bacterial acid phosphatase family
V469_21095	COG1366	Belongs to the anti-sigma-factor antagonist family
V469_21100	COG2172	sigma factor antagonist activity
V469_21105	COG5002	protein histidine kinase activity
V469_21105	COG2205	protein histidine kinase activity
V469_21105	COG0784	Response regulator, receiver
V469_21110	COG3437	response regulator, receiver
V469_21120	COG0477	Major facilitator Superfamily
V469_21135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V469_21140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V469_21140	COG1263	PTS System
V469_21160	COG0312	modulator of DNA gyrase
V469_21165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
V469_21175	COG3164	Protein of unknown function
V469_21180	COG1530	ribonuclease E activity
V469_21185	COG0424	maF-like protein
V469_21190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
V469_21195	COG1792	Involved in formation and maintenance of cell shape
V469_21200	COG1077	Cell shape determining protein MreB Mrl
V469_21225	COG4968	Prepilin-type N-terminal cleavage methylation domain
V469_21245	COG1459	type II secretion system
V469_21250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V469_21260	COG2842	Transposition protein
V469_21295	COG2199	diguanylate cyclase activity
V469_21295	COG2200	EAL domain
V469_21300	COG2200	EAL domain
V469_21305	COG0387	Pfam Sodium calcium exchanger
V469_21310	COG2986	histidine ammonia-lyase
V469_21315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
V469_21320	COG0010	Belongs to the arginase family
V469_21325	COG1228	amidohydrolase
V469_21330	COG2188	Transcriptional regulator
V469_21335	COG0288	reversible hydration of carbon dioxide
V469_21345	COG2177	Part of the ABC transporter FtsEX involved in
V469_21350	COG2884	Cell division ATP-binding protein ftsE
V469_21355	COG0552	protein localization to endoplasmic reticulum
V469_21360	COG0742	ribosomal rna small subunit methyltransferase
V469_21385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V469_21395	COG0741	lytic transglycosylase activity
V469_21420	COG2095	MarC family integral membrane protein
V469_21430	COG1301	dicarboxylic acid transport
V469_21455	COG3714	YhhN family
V469_21480	COG1770	oligopeptidase
V469_21495	COG4221	oxidoreductase activity
V469_21500	COG0583	DNA-binding transcription factor activity
V469_21505	COG2249	NAD(P)H dehydrogenase (quinone) activity
V469_21560	COG0203	ribosomal protein L17
V469_21565	COG0202	RNA polymerase activity
V469_21570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
V469_21575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
V469_21580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
V469_21585	COG0201	protein transport
V469_21590	COG0200	Binds to the 23S rRNA
V469_21595	COG1841	ribosomal large subunit assembly
V469_21600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
V469_21605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
V469_21610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
V469_21615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
V469_21620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
V469_21625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
V469_21630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
V469_21635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
V469_21640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
V469_21645	COG0255	Belongs to the universal ribosomal protein uL29 family
V469_21650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
V469_21655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
V469_21660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
V469_21665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
V469_21670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
V469_21675	COG0089	rRNA binding
V469_21680	COG0088	Forms part of the polypeptide exit tunnel
V469_21685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
V469_21690	COG0051	transcription antitermination factor activity, RNA binding
V469_21705	COG0745	RESPONSE REGULATOR receiver
V469_21710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V469_21715	COG2183	response to ionizing radiation
V469_21735	COG0596	Alpha beta hydrolase
V469_21740	COG1040	competence protein
V469_21745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
V469_21745	COG0316	Belongs to the HesB IscA family
V469_21750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
V469_21755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
V469_21760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V469_21765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
V469_21770	COG4942	peptidase
V469_21780	COG1609	Transcriptional regulator
V469_21785	COG0800	Aldolase
V469_21790	COG0129	dihydroxy-acid dehydratase activity
V469_21795	COG3265	gluconokinase activity
V469_21800	COG2610	gluconate transmembrane transporter activity
V469_21805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V469_21810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
V469_21820	COG0456	acetyltransferase
V469_21830	COG1490	D-aminoacyl-tRNA deacylase activity
V469_21835	COG1295	ribonuclease BN
V469_21845	COG0174	glutamine synthetase
V469_21855	COG3852	Histidine kinase
V469_21860	COG2204	response regulator
V469_21865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
V469_21870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V469_21880	COG3078	GTPase activator activity
V469_21895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
V469_21905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
V469_21910	COG0408	coproporphyrinogen oxidase activity
V469_21915	COG0009	L-threonylcarbamoyladenylate synthase
V469_21925	COG0551	DNA topoisomerase type I activity
V469_21930	COG2922	Belongs to the Smg family
V469_21935	COG0758	DNA mediated transformation
V469_21945	COG0242	peptide deformylase activity
V469_21950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
V469_21955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V469_21955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V469_21960	COG0569	domain protein
V469_21965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V469_21990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V469_21995	COG0686	Belongs to the AlaDH PNT family
V469_22000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
V469_22000	COG0519	Catalyzes the synthesis of GMP from XMP
V469_22015	COG1396	sequence-specific DNA binding
V469_22020	COG1012	belongs to the aldehyde dehydrogenase family
V469_22030	COG2962	Rard protein
V469_22040	COG1280	lysine exporter protein (LysE YggA)
V469_22050	COG2391	methyltransferase activity
V469_22055	COG1280	lysine exporter protein (LysE YggA)
V469_22100	COG0583	DNA-binding transcription factor activity
V469_22105	COG1943	Transposase
V469_22115	COG0210	DNA helicase
V469_22145	COG0583	DNA-binding transcription factor activity
V469_22165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
V469_22170	COG0385	Bile acid
V469_22175	COG0531	amino acid
V469_22180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V469_22185	COG0531	amino acid
V469_22190	COG2731	YhcH YjgK YiaL family protein
V469_22195	COG3250	beta-galactosidase activity
V469_22200	COG1609	Transcriptional regulator
V469_22235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
V469_22240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V469_22240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V469_22245	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
V469_22250	COG3074	FtsZ-dependent cytokinesis
V469_22260	COG1045	serine acetyltransferase
V469_22270	COG0745	RESPONSE REGULATOR receiver
V469_22275	COG2205	protein histidine kinase activity
V469_22280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
V469_22285	COG0534	Mate efflux family protein
V469_22300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
V469_22305	COG2937	Belongs to the GPAT DAPAT family
V469_22310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
V469_22315	COG3161	chorismate lyase activity
V469_22320	COG1580	Controls the rotational direction of flagella during chemotaxis
V469_22340	COG0604	alcohol dehydrogenase
V469_22345	COG1609	Transcriptional regulator
V469_22365	COG1519	Transferase
V469_22370	COG0859	PFAM glycosyl transferase family 9
V469_22375	COG0463	Glycosyl transferase, family 2
V469_22380	COG0859	PFAM glycosyl transferase family 9
V469_22385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
V469_22390	COG2990	Protein conserved in bacteria
V469_22395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
V469_22405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
V469_22410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
V469_22415	COG2003	Belongs to the UPF0758 family
V469_22420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
V469_22425	COG0756	dUTP diphosphatase activity
V469_22430	COG1309	transcriptional regulator
V469_22435	COG0668	transmembrane transport
V469_22445	COG0166	Belongs to the GPI family
V469_22450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
V469_22455	COG0583	DNA-binding transcription factor activity
V469_22500	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
V469_22505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V469_22510	COG1739	Uncharacterized protein family UPF0029
V469_22515	COG0006	proline dipeptidase activity
V469_22520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V469_22525	COG1250	3-hydroxyacyl-CoA dehydrogenase
V469_22525	COG1024	Enoyl-CoA hydratase
V469_22530	COG0183	Belongs to the thiolase family
V469_22535	COG0745	RESPONSE REGULATOR receiver
V469_22540	COG2205	protein histidine kinase activity
V469_22555	COG0425	Belongs to the sulfur carrier protein TusA family
V469_22560	COG0251	oxidation-reduction process
V469_22565	COG2885	chlorophyll binding
V469_22570	COG1335	isochorismatase
V469_22575	COG2818	Glycosylase
V469_22580	COG0752	glycyl-tRNA synthetase alpha subunit
V469_22585	COG0751	glycine-tRNA ligase activity
V469_22600	COG0529	Catalyzes the synthesis of activated sulfate
V469_22600	COG2046	Belongs to the sulfate adenylyltransferase family
V469_22620	COG0814	amino acid
V469_22625	COG0348	domain, Protein
V469_22635	COG0446	pyridine nucleotide-disulphide oxidoreductase
V469_22640	COG1773	rubredoxin
V469_22640	COG0426	domain, Protein
V469_22645	COG3604	Transcriptional regulator
V469_22650	COG2188	Transcriptional regulator
V469_22665	COG1609	Transcriptional regulator
V469_22675	COG0559	Belongs to the binding-protein-dependent transport system permease family
V469_22705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V469_22730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
V469_22740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
V469_22745	COG3118	belongs to the thioredoxin family
V469_22750	COG0513	Belongs to the DEAD box helicase family
V469_22755	COG0248	Ppx GppA phosphatase
V469_22770	COG0742	ribosomal rna small subunit methyltransferase
V469_22790	COG0084	hydrolase, TatD family'
V469_22795	COG0805	protein transport
V469_22800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V469_22810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
V469_22815	COG3165	ubiquinone biosynthetic process from chorismate
V469_22825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
V469_22830	COG0402	S-adenosylhomocysteine deaminase activity
V469_22875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V469_22880	COG0848	biopolymer transport protein
V469_22885	COG0811	peptide transport
V469_22890	COG0811	peptide transport
V469_22900	COG2771	luxR family
V469_22905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
V469_22910	COG1349	DNA-binding transcription factor activity
V469_22915	COG0745	RESPONSE REGULATOR receiver
V469_22920	COG2205	protein histidine kinase activity
V469_22930	COG4452	Inner membrane protein CreD
V469_22935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V469_22940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
V469_22945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
V469_22950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
V469_22955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
V469_22960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
V469_22965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
V469_22975	COG0356	it plays a direct role in the translocation of protons across the membrane
V469_22985	COG1475	DNA binding
V469_22990	COG1192	Involved in chromosome partitioning
V469_22995	COG0357	Ribosomal RNA small subunit methyltransferase G
V469_23000	COG0445	tRNA wobble uridine modification
V469_23005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V469_23010	COG4774	siderophore transport
V469_23015	COG4615	Cyclic peptide transporter
V469_23020	COG1120	ATPase activity
V469_23035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
V469_23040	COG0706	membrane insertase activity
V469_23045	COG0594	ribonuclease P activity
V469_23050	COG0230	Belongs to the bacterial ribosomal protein bL34 family