locus-tag	class	description
AS145_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS145_00010	COG0592	DNA-directed DNA polymerase activity
AS145_00020	COG0187	DNA topoisomerase II activity
AS145_00030	COG2378	regulation of single-species biofilm formation
AS145_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
AS145_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
AS145_00045	COG3977	Valine--pyruvate aminotransferase
AS145_00060	COG2814	Major facilitator Superfamily
AS145_00065	COG0745	RESPONSE REGULATOR receiver
AS145_00070	COG2205	protein histidine kinase activity
AS145_00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS145_00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_00095	COG4191	Histidine kinase
AS145_00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS145_00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_00110	COG1309	transcriptional regulator
AS145_00140	COG0469	pyruvate kinase activity
AS145_00145	COG2271	Major facilitator Superfamily
AS145_00150	COG1840	ABC-type Fe3 transport system, periplasmic component
AS145_00170	COG0561	phosphatase activity
AS145_00175	COG2267	carboxylic ester hydrolase activity
AS145_00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS145_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS145_00195	COG1758	RNA polymerase activity
AS145_00205	COG0859	PFAM glycosyl transferase family 9
AS145_00210	COG3642	lipopolysaccharide core region biosynthetic process
AS145_00245	COG0589	response to stress
AS145_00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AS145_00255	COG2199	diguanylate cyclase activity
AS145_00260	COG1528	Iron-storage protein
AS145_00265	COG2081	HI0933 family
AS145_00270	COG2223	nitrite transmembrane transporter activity
AS145_00290	COG3188	usher protein
AS145_00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_00310	COG2205	protein histidine kinase activity
AS145_00320	COG3275	phosphorelay sensor kinase activity
AS145_00325	COG3279	Response regulator of the LytR AlgR family
AS145_00330	COG2223	nitrite transmembrane transporter activity
AS145_00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS145_00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS145_00355	COG0583	DNA-binding transcription factor activity
AS145_00360	COG4206	TonB-dependent receptor
AS145_00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS145_00470	COG2003	Belongs to the UPF0758 family
AS145_00515	COG3311	Transcriptional regulator
AS145_00535	COG2771	luxR family
AS145_00545	COG3501	Rhs element vgr protein
AS145_00585	COG1358	cellular component organization or biogenesis
AS145_00645	COG0582	viral genome integration into host DNA
AS145_00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS145_00655	COG2166	iron-sulfur cluster assembly
AS145_00660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS145_00665	COG0210	DNA helicase
AS145_00675	COG3245	cytochrome
AS145_00680	COG1063	alcohol dehydrogenase
AS145_00685	COG0156	8-amino-7-oxononanoate synthase activity
AS145_00695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS145_00710	COG3306	glycosyltransferase involved in LPS biosynthesis
AS145_00730	COG1561	YicC-like family, N-terminal region
AS145_00735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AS145_00740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AS145_00750	COG0789	Transcriptional regulator
AS145_00755	COG3706	GGDEF domain
AS145_00755	COG2203	Gaf domain
AS145_00755	COG5001	Diguanylate cyclase
AS145_00755	COG4251	negative regulation of phosphorylation
AS145_00760	COG3084	Protein conserved in bacteria
AS145_00770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS145_00775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS145_00780	COG3639	organic phosphonate transmembrane transporter activity
AS145_00785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AS145_00790	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AS145_00800	COG1335	isochorismatase
AS145_00810	COG1683	Conserved Protein
AS145_00815	COG0204	Acyl-transferase
AS145_00820	COG0204	Acyl-transferase
AS145_00825	COG0606	chelatase, subunit chli
AS145_00835	COG3978	acetolactate synthase activity
AS145_00840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS145_00845	COG0129	dihydroxy-acid dehydratase activity
AS145_00865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS145_00870	COG0254	rRNA binding
AS145_00875	COG0702	epimerase
AS145_00880	COG0281	malic enzyme
AS145_00890	COG2205	protein histidine kinase activity
AS145_00895	COG0745	RESPONSE REGULATOR receiver
AS145_00900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS145_00915	COG0366	Alpha amylase catalytic
AS145_00930	COG0443	Heat shock 70 kDa protein
AS145_00935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS145_00940	COG3045	CreA protein
AS145_00955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS145_00960	COG0174	glutamine synthetase
AS145_00980	COG3842	ATPase activity
AS145_00985	COG1176	ABC-type spermidine putrescine transport system, permease component I
AS145_00990	COG1177	transmembrane transport
AS145_00995	COG2258	MOSC domain
AS145_01010	COG2050	protein possibly involved in aromatic compounds catabolism
AS145_01015	COG0514	ATP-dependent DNA helicase (RecQ)
AS145_01025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS145_01035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AS145_01040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS145_01050	COG2239	Acts as a magnesium transporter
AS145_01055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS145_01055	COG1648	precorrin-2 dehydrogenase activity
AS145_01060	COG2116	formate transmembrane transporter activity
AS145_01065	COG2146	nitrite reductase [NAD(P)H] activity
AS145_01070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS145_01085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AS145_01090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AS145_01110	COG1595	DNA-templated transcription, initiation
AS145_01115	COG3806	Anti-sigma factor
AS145_01120	COG1968	undecaprenyl-diphosphatase activity
AS145_01125	COG0667	Aldo Keto reductase
AS145_01130	COG2017	converts alpha-aldose to the beta-anomer
AS145_01135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AS145_01145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS145_01150	COG1609	Transcriptional regulator
AS145_01155	COG3250	beta-galactosidase activity
AS145_01175	COG0840	transmembrane signaling receptor activity
AS145_01200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS145_01205	COG1288	antiporter activity
AS145_01210	COG1438	arginine binding
AS145_01215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AS145_01220	COG0540	Belongs to the ATCase OTCase family
AS145_01235	COG0688	phosphatidylethanolamine metabolic process
AS145_01250	COG2207	Transcriptional regulator
AS145_01255	COG1979	alcohol dehydrogenase
AS145_01260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AS145_01265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AS145_01275	COG2964	Protein conserved in bacteria
AS145_01280	COG3681	Belongs to the UPF0597 family
AS145_01290	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS145_01295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS145_01300	COG0564	pseudouridine synthase activity
AS145_01310	COG0542	response to heat
AS145_01315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS145_01320	COG2502	aspartate--ammonia ligase
AS145_01325	COG1522	sequence-specific DNA binding
AS145_01335	COG5413	integral membrane protein
AS145_01355	COG2205	protein histidine kinase activity
AS145_01365	COG2204	response regulator
AS145_01380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AS145_01395	COG0745	RESPONSE REGULATOR receiver
AS145_01400	COG2205	protein histidine kinase activity
AS145_01410	COG0243	molybdopterin cofactor binding
AS145_01415	COG3005	denitrification pathway
AS145_01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS145_01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS145_01445	COG0569	domain protein
AS145_01450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS145_01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS145_01485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS145_01490	COG0250	Participates in transcription elongation, termination and antitermination
AS145_01495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AS145_01500	COG0081	regulation of translation
AS145_01505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AS145_01510	COG0222	ribosome binding
AS145_01515	COG0085	RNA polymerase activity
AS145_01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS145_01530	COG2964	Protein conserved in bacteria
AS145_01535	COG0251	oxidation-reduction process
AS145_01545	COG2923	Belongs to the DsrF TusC family
AS145_01550	COG2168	tRNA wobble position uridine thiolation
AS145_01560	COG0049	tRNA binding
AS145_01565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AS145_01570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS145_01575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AS145_01615	COG2252	PERMEase
AS145_01620	COG2376	Dihydroxyacetone kinase
AS145_01625	COG1461	Dihydroxyacetone kinase
AS145_01640	COG3284	Transcriptional regulator
AS145_01650	COG2957	Belongs to the agmatine deiminase family
AS145_01655	COG4221	oxidoreductase activity
AS145_01660	COG0628	permease
AS145_01665	COG0494	nUDIX hydrolase
AS145_01690	COG0753	catalase activity
AS145_01695	COG1247	-acetyltransferase
AS145_01715	COG3706	GGDEF domain
AS145_01725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS145_01735	COG1175	transmembrane transport
AS145_01760	COG0583	DNA-binding transcription factor activity
AS145_01770	COG1741	Belongs to the pirin family
AS145_01775	COG2259	Doxx family
AS145_01780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AS145_01785	COG1074	ATP-dependent DNA helicase activity
AS145_01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS145_01800	COG0346	lactoylglutathione lyase activity
AS145_01835	COG0745	RESPONSE REGULATOR receiver
AS145_01840	COG2205	protein histidine kinase activity
AS145_01845	COG4251	negative regulation of phosphorylation
AS145_01845	COG3706	GGDEF domain
AS145_01845	COG2203	Gaf domain
AS145_01845	COG5001	Diguanylate cyclase
AS145_01850	COG4771	TonB-dependent receptor
AS145_01855	COG1278	Cold shock
AS145_01875	COG0629	single-stranded DNA binding
AS145_01880	COG2197	response regulator
AS145_01885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS145_01895	COG3047	cAMP biosynthetic process
AS145_01900	COG0840	transmembrane signaling receptor activity
AS145_01925	COG3135	benzoate transporter
AS145_01930	COG1396	sequence-specific DNA binding
AS145_01960	COG2926	Belongs to the UPF0265 family
AS145_01970	COG3028	Belongs to the UPF0307 family
AS145_01975	COG0312	modulator of DNA gyrase
AS145_01980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS145_01985	COG5007	Belongs to the BolA IbaG family
AS145_01995	COG2854	intermembrane phospholipid transfer
AS145_02000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS145_02005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AS145_02010	COG1127	ABC transporter
AS145_02015	COG0517	IMP dehydrogenase activity
AS145_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS145_02020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AS145_02025	COG3117	lipopolysaccharide transmembrane transporter activity
AS145_02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AS145_02035	COG1137	ATPase activity
AS145_02040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS145_02050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_02055	COG1660	Displays ATPase and GTPase activities
AS145_02060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_02065	COG3711	transcriptional antiterminator
AS145_02080	COG3964	amidohydrolase
AS145_02110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS145_02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS145_02125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AS145_02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS145_02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AS145_02140	COG0723	plastoquinol--plastocyanin reductase activity
AS145_02145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS145_02150	COG2857	Cytochrome c1
AS145_02155	COG0625	glutathione transferase activity
AS145_02160	COG2969	positive regulation of protein catabolic process
AS145_02165	COG2823	Periplasmic or secreted lipoprotein
AS145_02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AS145_02175	COG0792	nuclease activity
AS145_02180	COG3107	peptidoglycan biosynthetic process
AS145_02185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AS145_02190	COG2001	Belongs to the MraZ family
AS145_02195	COG0275	rRNA processing
AS145_02200	COG3116	cell division
AS145_02205	COG0768	penicillin binding
AS145_02215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS145_02220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS145_02225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AS145_02230	COG0772	Belongs to the SEDS family
AS145_02235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS145_02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS145_02245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS145_02250	COG0849	cell division
AS145_02255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS145_02260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AS145_02270	COG0653	protein targeting
AS145_02280	COG0494	nUDIX hydrolase
AS145_02285	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AS145_02290	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AS145_02305	COG1459	type II secretion system
AS145_02310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS145_02335	COG2186	Transcriptional regulator
AS145_02340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AS145_02345	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS145_02350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS145_02355	COG5002	protein histidine kinase activity
AS145_02355	COG5001	Diguanylate cyclase
AS145_02355	COG3447	MASE1 domain protein
AS145_02365	COG0840	transmembrane signaling receptor activity
AS145_02370	COG0840	transmembrane signaling receptor activity
AS145_02375	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS145_02380	COG1049	propionate catabolic process, 2-methylcitrate cycle
AS145_02395	COG1280	lysine exporter protein (LysE YggA)
AS145_02405	COG0523	cobalamin synthesis protein
AS145_02410	COG0477	Major facilitator Superfamily
AS145_02425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS145_02430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS145_02475	COG0835	chemotaxis
AS145_02475	COG0784	Response regulator, receiver
AS145_02480	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_02485	COG1444	tRNA N-acetyltransferase activity
AS145_02510	COG1803	Methylglyoxal synthase
AS145_02525	COG0252	asparaginase activity
AS145_02545	COG1263	PTS System
AS145_02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_02550	COG0366	Alpha amylase catalytic
AS145_02555	COG0110	maltose O-acetyltransferase activity
AS145_02560	COG1522	sequence-specific DNA binding
AS145_02565	COG5006	permease, DMT superfamily
AS145_02575	COG1012	belongs to the aldehyde dehydrogenase family
AS145_02580	COG1177	transmembrane transport
AS145_02585	COG1176	ABC-type spermidine putrescine transport system, permease component I
AS145_02590	COG3842	ATPase activity
AS145_02595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AS145_02600	COG0583	DNA-binding transcription factor activity
AS145_02605	COG1757	Na H antiporter
AS145_02650	COG0297	glycogen (starch) synthase activity
AS145_02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS145_02660	COG2813	Specifically methylates the guanine in position
AS145_02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS145_02670	COG4251	negative regulation of phosphorylation
AS145_02670	COG2203	Gaf domain
AS145_02670	COG5001	Diguanylate cyclase
AS145_02670	COG3706	GGDEF domain
AS145_02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS145_02690	COG2995	paraquat-inducible protein a
AS145_02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS145_02695	COG3008	intermembrane lipid transfer
AS145_02700	COG3009	Protein conserved in bacteria
AS145_02705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AS145_02705	COG2885	chlorophyll binding
AS145_02715	COG3240	lipase activity
AS145_02720	COG3111	PFAM Bacterial OB fold (BOF) protein
AS145_02730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AS145_02735	COG1194	a g-specific adenine glycosylase
AS145_02745	COG3267	Type II secretory pathway component ExeA
AS145_02745	COG3409	Peptidoglycan-binding domain 1 protein
AS145_02755	COG0617	tRNA 3'-terminal CCA addition
AS145_02770	COG1346	cytolysis
AS145_02775	COG1380	Effector of murein hydrolase LrgA
AS145_02780	COG0583	DNA-binding transcription factor activity
AS145_02805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS145_02810	COG0306	phosphate transporter
AS145_02815	COG1392	Phosphate transport regulator
AS145_02830	COG1560	Kdo2-lipid A biosynthetic process
AS145_02835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AS145_02835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AS145_02840	COG1538	Outer membrane efflux protein
AS145_02845	COG0494	nUDIX hydrolase
AS145_02850	COG3151	Protein conserved in bacteria
AS145_02860	COG3150	esterase
AS145_02865	COG1051	belongs to the nudix hydrolase family
AS145_02880	COG1566	PFAM secretion protein HlyD family protein
AS145_02885	COG1289	transmembrane transporter activity
AS145_02890	COG0187	DNA topoisomerase II activity
AS145_02935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS145_02960	COG0204	Acyl-transferase
AS145_02965	COG1842	Phage shock protein A
AS145_02980	COG2827	Endonuclease containing a URI domain
AS145_02990	COG2962	Rard protein
AS145_02995	COG1573	uracil-dna glycosylase
AS145_03000	COG0697	spore germination
AS145_03010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS145_03015	COG1121	(ABC) transporter
AS145_03020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AS145_03040	COG0739	heme binding
AS145_03050	COG3068	Protein conserved in bacteria
AS145_03070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AS145_03075	COG0582	viral genome integration into host DNA
AS145_03090	COG1546	Belongs to the CinA family
AS145_03095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS145_03105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS145_03110	COG0527	aspartate kinase activity
AS145_03115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AS145_03170	COG1686	Belongs to the peptidase S11 family
AS145_03175	COG0586	Pfam SNARE associated Golgi protein
AS145_03180	COG1253	flavin adenine dinucleotide binding
AS145_03185	COG0525	valine-tRNA ligase activity
AS145_03190	COG2927	DNA polymerase III (CHI subunit)
AS145_03195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS145_03200	COG0795	lipopolysaccharide-transporting ATPase activity
AS145_03205	COG0795	lipopolysaccharide-transporting ATPase activity
AS145_03220	COG0582	viral genome integration into host DNA
AS145_03235	COG3561	AntA/AntB antirepressor
AS145_03260	COG0004	ammonium transporteR
AS145_03265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS145_03275	COG0084	hydrolase, TatD family'
AS145_03280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS145_03290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS145_03295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AS145_03300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AS145_03305	COG0813	purine-nucleoside phosphorylase activity
AS145_03310	COG5002	protein histidine kinase activity
AS145_03310	COG5001	Diguanylate cyclase
AS145_03310	COG3447	MASE1 domain protein
AS145_03320	COG0560	Phosphoserine phosphatase
AS145_03345	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AS145_03350	COG0776	regulation of translation
AS145_03360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS145_03390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AS145_03395	COG0513	Belongs to the DEAD box helicase family
AS145_03400	COG3022	response to hydroperoxide
AS145_03415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS145_03420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS145_03425	COG0762	integral membrane protein
AS145_03430	COG1872	DUF167
AS145_03445	COG4166	transmembrane transport
AS145_03455	COG0110	maltose O-acetyltransferase activity
AS145_03465	COG1024	Enoyl-CoA hydratase
AS145_03480	COG4221	oxidoreductase activity
AS145_03485	COG0442	prolyl-tRNA aminoacylation
AS145_03490	COG0840	transmembrane signaling receptor activity
AS145_03495	COG0632	four-way junction helicase activity
AS145_03500	COG2255	four-way junction helicase activity
AS145_03505	COG1271	oxidase subunit
AS145_03510	COG1294	oxidase, subunit
AS145_03515	COG4890	Cyd operon protein YbgT
AS145_03520	COG3790	cyd operon protein YbgE
AS145_03525	COG0824	Thioesterase
AS145_03530	COG0811	peptide transport
AS145_03545	COG0823	Involved in the tonB-independent uptake of proteins
AS145_03550	COG2885	chlorophyll binding
AS145_03555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AS145_03610	COG0840	transmembrane signaling receptor activity
AS145_03615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AS145_03620	COG0676	glucose-6-phosphate 1-epimerase activity
AS145_03625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS145_03630	COG1640	4-alpha-glucanotransferase
AS145_03635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AS145_03655	COG1051	belongs to the nudix hydrolase family
AS145_03660	COG2130	NADP-dependent
AS145_03665	COG1764	response to oxidative stress
AS145_03670	COG1846	Transcriptional regulator
AS145_03685	COG1522	sequence-specific DNA binding
AS145_03700	COG0561	phosphatase activity
AS145_03715	COG0733	neurotransmitter:sodium symporter activity
AS145_03725	COG0733	neurotransmitter:sodium symporter activity
AS145_03750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS145_03765	COG1794	racemase activity, acting on amino acids and derivatives
AS145_03780	COG2731	YhcH YjgK YiaL family protein
AS145_03790	COG0668	transmembrane transport
AS145_03800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS145_03835	COG0583	DNA-binding transcription factor activity
AS145_03840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AS145_03850	COG0488	(ABC) transporter
AS145_03855	COG0517	IMP dehydrogenase activity
AS145_03855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS145_03860	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS145_03865	COG0330	HflC and HflK could
AS145_03870	COG1648	precorrin-2 dehydrogenase activity
AS145_03870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS145_03875	COG0175	sulfate reduction
AS145_03880	COG2895	sulfate adenylyltransferase (ATP) activity
AS145_03885	COG3273	potassium ion transport
AS145_03885	COG0471	metal ion transport
AS145_03890	COG0529	Catalyzes the synthesis of activated sulfate
AS145_03910	COG0840	transmembrane signaling receptor activity
AS145_03945	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AS145_03960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AS145_03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS145_03970	COG0163	prenyltransferase activity
AS145_03985	COG1131	(ABC) transporter
AS145_03990	COG0842	Transport permease protein
AS145_03995	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AS145_04000	COG1924	4 iron, 4 sulfur cluster binding
AS145_04020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS145_04025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AS145_04040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS145_04045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS145_04050	COG1489	DNA binding
AS145_04060	COG1643	Atp-dependent helicase
AS145_04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS145_04070	COG0346	lactoylglutathione lyase activity
AS145_04080	COG2076	Multidrug Resistance protein
AS145_04090	COG3437	response regulator, receiver
AS145_04090	COG0784	Response regulator, receiver
AS145_04100	COG0671	phosphoesterase, PA-phosphatase related
AS145_04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS145_04120	COG0038	chloride channel
AS145_04130	COG0316	Belongs to the HesB IscA family
AS145_04155	COG1280	lysine exporter protein (LysE YggA)
AS145_04160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AS145_04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_04205	COG0745	RESPONSE REGULATOR receiver
AS145_04210	COG3104	oligopeptide transport
AS145_04215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS145_04220	COG1555	photosystem II stabilization
AS145_04230	COG2350	Protein conserved in bacteria
AS145_04235	COG2917	probably involved in intracellular septation
AS145_04240	COG0076	glutamate decarboxylase activity
AS145_04245	COG1272	protein, Hemolysin III
AS145_04250	COG0569	domain protein
AS145_04250	COG2985	domain, Protein
AS145_04260	COG0784	Response regulator, receiver
AS145_04260	COG0835	chemotaxis
AS145_04265	COG2755	lipolytic protein G-D-S-L family
AS145_04270	COG4181	ATPase activity
AS145_04275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AS145_04280	COG1090	epimerase
AS145_04285	COG2200	EAL domain
AS145_04290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS145_04295	COG4935	Belongs to the peptidase S8 family
AS145_04295	COG2234	aminopeptidase activity
AS145_04300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS145_04305	COG3171	Protein conserved in bacteria
AS145_04310	COG2066	Belongs to the glutaminase family
AS145_04315	COG2897	thiosulfate sulfurtransferase activity
AS145_04320	COG1404	Belongs to the peptidase S8 family
AS145_04330	COG1132	(ABC) transporter
AS145_04350	COG3291	Pkd domain containing protein
AS145_04350	COG4412	M6 family metalloprotease domain protein
AS145_04355	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AS145_04360	COG5001	Diguanylate cyclase
AS145_04360	COG3300	MHYT domain
AS145_04380	COG4628	conserved protein (DUF2132)
AS145_04385	COG0688	phosphatidylethanolamine metabolic process
AS145_04390	COG1162	GTPase activity
AS145_04395	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AS145_04425	COG1278	Cold shock
AS145_04435	COG0840	transmembrane signaling receptor activity
AS145_04440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS145_04445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS145_04515	COG0848	biopolymer transport protein
AS145_04520	COG0811	peptide transport
AS145_04525	COG0811	peptide transport
AS145_04540	COG4174	ABC transporter (Permease)
AS145_04545	COG4239	(ABC) transporter, permease
AS145_04555	COG0444	Belongs to the ABC transporter superfamily
AS145_04560	COG4608	Belongs to the ABC transporter superfamily
AS145_04565	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS145_04570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AS145_04590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AS145_04615	COG0243	molybdopterin cofactor binding
AS145_04630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS145_04630	COG1116	anion transmembrane transporter activity
AS145_04635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS145_04640	COG1116	anion transmembrane transporter activity
AS145_04645	COG2146	nitrite reductase [NAD(P)H] activity
AS145_04645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS145_04650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS145_04650	COG2146	nitrite reductase [NAD(P)H] activity
AS145_04655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS145_04660	COG2313	pseudouridylate synthase activity
AS145_04670	COG1858	cytochrome C peroxidase
AS145_04705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS145_04710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS145_04735	COG2986	histidine ammonia-lyase
AS145_04760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS145_04770	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_04785	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS145_04795	COG2966	Psort location CytoplasmicMembrane, score
AS145_04800	COG3610	response to peptide
AS145_04810	COG4175	Glycine betaine
AS145_04815	COG4176	ABC-type proline glycine betaine transport system permease component
AS145_04820	COG2113	Glycine betaine
AS145_04825	COG0175	sulfate reduction
AS145_04830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS145_04835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS145_04840	COG0384	phenazine biosynthesis protein PhzF
AS145_04845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AS145_04850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS145_04860	COG0786	glutamate:sodium symporter activity
AS145_04865	COG0252	asparaginase activity
AS145_04870	COG3139	Protein of unknown function (DUF1315)
AS145_04890	COG0616	signal peptide processing
AS145_04895	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS145_04895	COG1902	pentaerythritol trinitrate reductase activity
AS145_04900	COG0778	Nitroreductase
AS145_04915	COG2264	protein methyltransferase activity
AS145_04920	COG0604	alcohol dehydrogenase
AS145_04925	COG0583	DNA-binding transcription factor activity
AS145_04930	COG2190	(PTS) system
AS145_04930	COG1263	PTS System
AS145_04930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_04935	COG4145	pantothenate transmembrane transporter activity
AS145_04945	COG0439	Biotin carboxylase
AS145_04950	COG0511	ligase activity, forming carbon-carbon bonds
AS145_04955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AS145_04960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS145_04970	COG5001	Diguanylate cyclase
AS145_04970	COG3300	MHYT domain
AS145_04990	COG3381	protein complex oligomerization
AS145_05005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS145_05020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS145_05025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS145_05025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS145_05045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS145_05050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS145_05055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AS145_05060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS145_05085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AS145_05090	COG0142	geranyltranstransferase activity
AS145_05095	COG1722	exodeoxyribonuclease VII activity
AS145_05100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS145_05105	COG1360	Flagellar Motor Protein
AS145_05110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS145_05120	COG1534	Rna-binding protein
AS145_05125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AS145_05130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS145_05135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS145_05140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS145_05145	COG0149	triose-phosphate isomerase activity
AS145_05150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS145_05165	COG0779	Required for maturation of 30S ribosomal subunits
AS145_05170	COG0195	Participates in both transcription termination and antitermination
AS145_05175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AS145_05180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS145_05185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS145_05190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AS145_05195	COG1185	polyribonucleotide nucleotidyltransferase activity
AS145_05210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AS145_05220	COG0114	fumarate hydratase activity
AS145_05230	COG1966	Carbon starvation protein
AS145_05235	COG3279	Response regulator of the LytR AlgR family
AS145_05305	COG0312	modulator of DNA gyrase
AS145_05310	COG0312	modulator of DNA gyrase
AS145_05315	COG0716	FMN binding
AS145_05320	COG4974	Belongs to the 'phage' integrase family
AS145_05325	COG1970	mechanosensitive ion channel activity
AS145_05330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS145_05340	COG0789	Transcriptional regulator
AS145_05355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AS145_05360	COG3545	Serine hydrolase
AS145_05370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS145_05375	COG0321	lipoyl(octanoyl) transferase activity
AS145_05380	COG2921	Belongs to the UPF0250 family
AS145_05385	COG1686	Belongs to the peptidase S11 family
AS145_05390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AS145_05395	COG2951	lytic endotransglycosylase activity
AS145_05400	COG0772	Belongs to the SEDS family
AS145_05405	COG0768	penicillin binding
AS145_05410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AS145_05415	COG0799	negative regulation of ribosome biogenesis
AS145_05420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS145_05435	COG0495	leucyl-tRNA aminoacylation
AS145_05440	COG2888	peptidyl-tyrosine sulfation
AS145_05445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AS145_05450	COG4535	Mg2 and Co2 transporter CorC
AS145_05455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AS145_05460	COG1702	phosphate starvation-inducible protein PhoH
AS145_05465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS145_05470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS145_05475	COG1335	isochorismatase
AS145_05485	COG3706	GGDEF domain
AS145_05500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS145_05510	COG3706	GGDEF domain
AS145_05520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS145_05530	COG3647	Membrane
AS145_05535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS145_05545	COG0516	GMP reductase activity
AS145_05555	COG0642	Histidine kinase
AS145_05560	COG0745	RESPONSE REGULATOR receiver
AS145_05595	COG3214	Protein conserved in bacteria
AS145_05620	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AS145_05625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS145_05630	COG1053	succinate dehydrogenase
AS145_05640	COG0584	glycerophosphoryl diester phosphodiesterase
AS145_05645	COG3264	Mechanosensitive ion channel
AS145_05645	COG1511	domain protein
AS145_05655	COG0739	heme binding
AS145_05670	COG0583	DNA-binding transcription factor activity
AS145_05690	COG0583	DNA-binding transcription factor activity
AS145_05695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AS145_05725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AS145_05730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AS145_05740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AS145_05745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS145_05755	COG0180	Tryptophanyl-tRNA synthetase
AS145_05770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS145_05780	COG1012	belongs to the aldehyde dehydrogenase family
AS145_05790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS145_05800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_05800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS145_05800	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS145_05800	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS145_05810	COG0366	Alpha amylase catalytic
AS145_05830	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AS145_05840	COG0490	domain, Protein
AS145_05840	COG0471	metal ion transport
AS145_05885	COG0012	GTP binding
AS145_05890	COG0193	aminoacyl-tRNA hydrolase activity
AS145_05895	COG0737	Belongs to the 5'-nucleotidase family
AS145_05900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS145_05915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AS145_05920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AS145_05925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS145_05930	COG2890	protein-(glutamine-N5) methyltransferase activity
AS145_05940	COG2912	Transglutaminase-like superfamily
AS145_05945	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AS145_05950	COG1301	dicarboxylic acid transport
AS145_05960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS145_05975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS145_05980	COG1115	amino acid carrier protein
AS145_05995	COG0714	Associated with various cellular activities
AS145_06005	COG3104	oligopeptide transport
AS145_06010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AS145_06015	COG1678	Uncharacterized ACR, COG1678
AS145_06025	COG0189	ligase activity
AS145_06030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS145_06040	COG3091	SprT-like family
AS145_06050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AS145_06060	COG2200	EAL domain
AS145_06085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AS145_06090	COG0739	heme binding
AS145_06095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS145_06100	COG3408	Glycogen debranching enzyme
AS145_06100	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AS145_06110	COG1881	PFAM PEBP family protein
AS145_06120	COG0583	DNA-binding transcription factor activity
AS145_06130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS145_06140	COG0583	DNA-binding transcription factor activity
AS145_06145	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_06150	COG0616	signal peptide processing
AS145_06155	COG3724	N-succinylarginine dihydrolase activity
AS145_06160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS145_06175	COG0840	transmembrane signaling receptor activity
AS145_06185	COG2971	BadF BadG BcrA BcrD
AS145_06195	COG4608	Belongs to the ABC transporter superfamily
AS145_06200	COG0444	Belongs to the ABC transporter superfamily
AS145_06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS145_06210	COG0601	transmembrane transport
AS145_06215	COG4166	transmembrane transport
AS145_06250	COG3220	belongs to the UPF0276 family
AS145_06280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AS145_06285	COG1289	transmembrane transporter activity
AS145_06290	COG0303	'Molybdopterin
AS145_06295	COG0746	molybdenum cofactor guanylyltransferase activity
AS145_06305	COG4662	Binding-protein-dependent transport system inner membrane component
AS145_06315	COG2204	response regulator
AS145_06320	COG3852	Histidine kinase
AS145_06325	COG1910	domain protein
AS145_06330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS145_06365	COG3383	formate dehydrogenase (NAD+) activity
AS145_06365	COG3383	formate dehydrogenase (NAD+) activity
AS145_06370	COG0437	4 iron, 4 sulfur cluster binding
AS145_06385	COG0281	malic enzyme
AS145_06405	COG2706	6-phosphogluconolactonase activity
AS145_06415	COG1196	nuclear chromosome segregation
AS145_06415	COG3264	Mechanosensitive ion channel
AS145_06420	COG0469	pyruvate kinase activity
AS145_06435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS145_06435	COG4651	solute:proton antiporter activity
AS145_06445	COG2974	May be involved in recombination
AS145_06455	COG0420	3'-5' exonuclease activity
AS145_06460	COG0419	ATPase involved in DNA repair
AS145_06475	COG3038	cytochrome b561
AS145_06490	COG2190	(PTS) system
AS145_06500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_06505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS145_06510	COG0542	response to heat
AS145_06525	COG1720	tRNA m6t6A37 methyltransferase activity
AS145_06545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AS145_06550	COG4988	ABC transporter
AS145_06565	COG0745	RESPONSE REGULATOR receiver
AS145_06575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS145_06590	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AS145_06595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AS145_06605	COG0083	homoserine kinase activity
AS145_06610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS145_06615	COG4319	ketosteroid isomerase
AS145_06630	COG0488	(ABC) transporter
AS145_06640	COG0813	purine-nucleoside phosphorylase activity
AS145_06655	COG2205	protein histidine kinase activity
AS145_06655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_06660	COG3384	dioxygenase
AS145_06670	COG1283	sodium-dependent phosphate transmembrane transporter activity
AS145_06680	COG0531	amino acid
AS145_06690	COG0531	amino acid
AS145_06705	COG1917	Cupin 2, conserved barrel domain protein
AS145_06705	COG1396	sequence-specific DNA binding
AS145_06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS145_06730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS145_06740	COG2375	cellular response to nickel ion
AS145_06745	COG1538	Outer membrane efflux protein
AS145_06750	COG1136	(ABC) transporter
AS145_06750	COG0577	efflux transmembrane transporter activity
AS145_06755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_06765	COG1227	inorganic diphosphatase activity
AS145_06775	COG0497	DNA recombination
AS145_06780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS145_06785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AS145_06790	COG0443	Heat shock 70 kDa protein
AS145_06795	COG0484	heat shock protein binding
AS145_06825	COG1285	pathogenesis
AS145_06840	COG0640	Transcriptional regulator
AS145_06870	COG0095	Lipoate-protein ligase
AS145_06890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS145_06895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_06915	COG0708	Exodeoxyribonuclease III
AS145_06930	COG2211	Major facilitator Superfamily
AS145_06975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS145_06980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS145_06985	COG1845	cytochrome c oxidase, subunit III
AS145_06990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS145_06995	COG0109	protoheme IX farnesyltransferase activity
AS145_07000	COG2814	Major facilitator Superfamily
AS145_07010	COG0784	Response regulator, receiver
AS145_07010	COG2198	Histidine kinase
AS145_07010	COG2205	protein histidine kinase activity
AS145_07015	COG1879	ABC-type sugar transport system periplasmic component
AS145_07025	COG0745	RESPONSE REGULATOR receiver
AS145_07040	COG3381	protein complex oligomerization
AS145_07080	COG2003	Belongs to the UPF0758 family
AS145_07120	COG0583	DNA-binding transcription factor activity
AS145_07135	COG0549	Belongs to the carbamate kinase family
AS145_07140	COG1304	FMN binding
AS145_07145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS145_07150	COG1335	isochorismatase
AS145_07165	COG3311	Transcriptional regulator
AS145_07185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS145_07215	COG0159	tryptophan synthase activity
AS145_07220	COG0133	tryptophan synthase activity
AS145_07225	COG0134	indole-3-glycerol-phosphate synthase activity
AS145_07225	COG0135	phosphoribosylanthranilate isomerase activity
AS145_07230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS145_07235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS145_07235	COG0512	Glutamine amidotransferase of anthranilate synthase
AS145_07240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AS145_07250	COG0009	L-threonylcarbamoyladenylate synthase
AS145_07260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS145_07270	COG1946	Acyl-CoA thioesterase
AS145_07285	COG1309	transcriptional regulator
AS145_07290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_07295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS145_07315	COG2244	polysaccharide biosynthetic process
AS145_07325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AS145_07330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS145_07335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AS145_07335	COG0662	Cupin 2, conserved barrel domain protein
AS145_07345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS145_07350	COG1091	dTDP-4-dehydrorhamnose reductase activity
AS145_07355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AS145_07365	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AS145_07385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS145_07395	COG3132	Protein of unknown function, DUF480
AS145_07435	COG1278	Cold shock
AS145_07465	COG0697	spore germination
AS145_07470	COG1349	DNA-binding transcription factor activity
AS145_07480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS145_07485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS145_07500	COG1187	pseudouridine synthase activity
AS145_07515	COG0622	Phosphoesterase
AS145_07530	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AS145_07535	COG0835	chemotaxis
AS145_07535	COG0784	Response regulator, receiver
AS145_07540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS145_07545	COG1815	bacterial-type flagellum-dependent cell motility
AS145_07550	COG1558	bacterial-type flagellum-dependent cell motility
AS145_07565	COG4787	bacterial-type flagellum-dependent cell motility
AS145_07570	COG4786	Flagellar basal body rod
AS145_07575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AS145_07580	COG1706	bacterial-type flagellum-dependent cell motility
AS145_07585	COG3951	Flagellar rod assembly protein muramidase FlgJ
AS145_07585	COG1705	Flagellar rod assembly protein muramidase FlgJ
AS145_07590	COG1256	bacterial-type flagellum assembly
AS145_07600	COG2239	Acts as a magnesium transporter
AS145_07605	COG0248	Ppx GppA phosphatase
AS145_07610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AS145_07615	COG2716	regulation of RNA biosynthetic process
AS145_07625	COG2204	response regulator
AS145_07630	COG3852	Histidine kinase
AS145_07635	COG2204	response regulator
AS145_07640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS145_07645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS145_07650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AS145_07655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS145_07675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS145_07685	COG0590	tRNA wobble adenosine to inosine editing
AS145_07690	COG0573	inorganic phosphate transmembrane transporter activity
AS145_07695	COG0581	inorganic phosphate transmembrane transporter activity
AS145_07705	COG0704	Plays a role in the regulation of phosphate uptake
AS145_07710	COG1253	flavin adenine dinucleotide binding
AS145_07725	COG0531	amino acid
AS145_07740	COG1126	abc transporter atp-binding protein
AS145_07745	COG0765	amino acid transport
AS145_07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_07755	COG3706	GGDEF domain
AS145_07760	COG2271	Major facilitator Superfamily
AS145_07775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS145_07805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AS145_07810	COG0477	Major facilitator Superfamily
AS145_07815	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS145_07825	COG1199	ATP-dependent helicase activity
AS145_07830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AS145_07840	COG1448	Aminotransferase
AS145_07845	COG0433	COG0433 Predicted ATPase
AS145_07915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS145_07925	COG1522	sequence-specific DNA binding
AS145_07955	COG2916	Histone family protein nucleoid-structuring protein H-NS
AS145_08000	COG1663	tetraacyldisaccharide 4'-kinase activity
AS145_08005	COG2835	tetraacyldisaccharide 4'-kinase activity
AS145_08010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AS145_08015	COG2197	response regulator
AS145_08020	COG0322	excinuclease ABC activity
AS145_08105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS145_08155	COG4695	Portal protein
AS145_08240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS145_08250	COG4974	Belongs to the 'phage' integrase family
AS145_08260	COG0582	viral genome integration into host DNA
AS145_08280	COG4372	Transposase
AS145_08300	COG3962	Belongs to the TPP enzyme family
AS145_08305	COG0673	inositol 2-dehydrogenase activity
AS145_08310	COG1879	ABC-type sugar transport system periplasmic component
AS145_08320	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS145_08325	COG0673	inositol 2-dehydrogenase activity
AS145_08330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS145_08340	COG3718	enzyme involved in inositol metabolism
AS145_08345	COG3039	Transposase
AS145_08350	COG2963	transposase activity
AS145_08355	COG2801	Transposase and inactivated derivatives
AS145_08420	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AS145_08425	COG0437	4 iron, 4 sulfur cluster binding
AS145_08430	COG3301	Polysulphide reductase, NrfD
AS145_08435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS145_08445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS145_08450	COG0215	cysteine-tRNA ligase activity
AS145_08465	COG2199	diguanylate cyclase activity
AS145_08465	COG2203	Gaf domain
AS145_08495	COG2119	membrane
AS145_08500	COG0023	Translation Initiation Factor
AS145_08525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS145_08540	COG2205	protein histidine kinase activity
AS145_08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_08550	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AS145_08560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS145_08565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AS145_08570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS145_08575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS145_08580	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS145_08585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS145_08595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AS145_08600	COG0505	Belongs to the CarA family
AS145_08605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AS145_08610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS145_08640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS145_08645	COG0513	Belongs to the DEAD box helicase family
AS145_08655	COG4104	PAAR repeat-containing protein
AS145_08670	COG0789	Transcriptional regulator
AS145_08685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_08690	COG0765	amino acid transport
AS145_08700	COG0493	'glutamate synthase
AS145_08705	COG0070	glutamate synthase
AS145_08705	COG0069	glutamate synthase activity
AS145_08705	COG0067	glutamate synthase
AS145_08710	COG1242	4 iron, 4 sulfur cluster binding
AS145_08775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AS145_08780	COG0574	Belongs to the PEP-utilizing enzyme family
AS145_08780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS145_08825	COG1464	Belongs to the NlpA lipoprotein family
AS145_08830	COG0671	phosphoesterase, PA-phosphatase related
AS145_08835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS145_08840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS145_08850	COG0101	tRNA pseudouridine synthase activity
AS145_08855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AS145_08860	COG0285	dihydrofolate synthase activity
AS145_08865	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AS145_08870	COG2920	part of a sulfur-relay system
AS145_08875	COG1289	transmembrane transporter activity
AS145_08880	COG0670	Belongs to the BI1 family
AS145_08900	COG2194	sulfuric ester hydrolase activity
AS145_08910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AS145_08910	COG0392	lysyltransferase activity
AS145_08920	COG0840	transmembrane signaling receptor activity
AS145_08925	COG5001	Diguanylate cyclase
AS145_08930	COG0564	pseudouridine synthase activity
AS145_08945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AS145_08955	COG0625	glutathione transferase activity
AS145_08960	COG0625	glutathione transferase activity
AS145_08970	COG0367	asparagine synthase
AS145_08980	COG4651	solute:proton antiporter activity
AS145_08980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS145_08985	COG0647	UMP catabolic process
AS145_08990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS145_08995	COG1902	pentaerythritol trinitrate reductase activity
AS145_09000	COG1253	flavin adenine dinucleotide binding
AS145_09010	COG0277	FAD linked oxidase domain protein
AS145_09010	COG0247	lactate metabolic process
AS145_09020	COG2050	protein possibly involved in aromatic compounds catabolism
AS145_09030	COG2056	Na+-H+ antiporter family
AS145_09035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS145_09050	COG0346	lactoylglutathione lyase activity
AS145_09055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS145_09065	COG4659	FMN binding
AS145_09070	COG4658	electron transport chain
AS145_09080	COG2878	Part of a membrane complex involved in electron transport
AS145_09085	COG4657	Part of a membrane complex involved in electron transport
AS145_09090	COG0697	spore germination
AS145_09105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AS145_09110	COG1288	antiporter activity
AS145_09115	COG0436	Aminotransferase
AS145_09125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AS145_09130	COG2027	D-alanyl-D-alanine carboxypeptidase
AS145_09135	COG1061	Type III restriction enzyme res subunit
AS145_09140	COG1566	PFAM secretion protein HlyD family protein
AS145_09150	COG1966	Carbon starvation protein
AS145_09155	COG3279	Response regulator of the LytR AlgR family
AS145_09160	COG3275	phosphorelay sensor kinase activity
AS145_09165	COG2199	diguanylate cyclase activity
AS145_09165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AS145_09170	COG1012	belongs to the aldehyde dehydrogenase family
AS145_09170	COG1454	alcohol dehydrogenase
AS145_09180	COG2095	MarC family integral membrane protein
AS145_09190	COG0601	transmembrane transport
AS145_09195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS145_09200	COG0444	Belongs to the ABC transporter superfamily
AS145_09215	COG0861	Integral membrane protein TerC family
AS145_09220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS145_09230	COG1301	dicarboxylic acid transport
AS145_09245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS145_09260	COG0537	adenosine 5'-monophosphoramidase activity
AS145_09295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS145_09300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS145_09310	COG2354	Protein conserved in bacteria
AS145_09325	COG2233	PERMEase
AS145_09335	COG1252	NADH dehydrogenase
AS145_09355	COG0393	Putative heavy-metal-binding
AS145_09365	COG1648	precorrin-2 dehydrogenase activity
AS145_09365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS145_09370	COG2221	Nitrite and sulphite reductase 4Fe-4S
AS145_09385	COG4667	esterase of the alpha-beta hydrolase superfamily
AS145_09390	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS145_09395	COG1368	sulfuric ester hydrolase activity
AS145_09405	COG0527	aspartate kinase activity
AS145_09410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AS145_09410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS145_09415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS145_09440	COG0596	Alpha beta hydrolase
AS145_09445	COG0346	lactoylglutathione lyase activity
AS145_09455	COG0583	DNA-binding transcription factor activity
AS145_09460	COG1620	l-lactate permease
AS145_09470	COG1139	Iron-sulfur cluster binding protein
AS145_09495	COG1136	(ABC) transporter
AS145_09505	COG2814	Major facilitator Superfamily
AS145_09525	COG0672	)-iron permease
AS145_09555	COG0659	secondary active sulfate transmembrane transporter activity
AS145_09600	COG2963	transposase activity
AS145_09620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS145_09625	COG0840	transmembrane signaling receptor activity
AS145_09635	COG2201	protein-glutamate methylesterase activity
AS145_09645	COG0835	chemotaxis
AS145_09650	COG0840	transmembrane signaling receptor activity
AS145_09650	COG3290	protein histidine kinase activity
AS145_09655	COG0643	Histidine kinase
AS145_09655	COG2198	Histidine kinase
AS145_09665	COG0745	RESPONSE REGULATOR receiver
AS145_09670	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AS145_09675	COG0437	4 iron, 4 sulfur cluster binding
AS145_09680	COG5557	Pfam Polysulphide reductase, NrfD
AS145_09685	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AS145_09690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AS145_09695	COG1773	rubredoxin
AS145_09700	COG0747	negative chemotaxis
AS145_09705	COG0601	transmembrane transport
AS145_09710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS145_09715	COG0444	Belongs to the ABC transporter superfamily
AS145_09720	COG3842	ATPase activity
AS145_09725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AS145_09730	COG0375	protein maturation
AS145_09735	COG0309	Hydrogenase expression formation protein (HypE)
AS145_09745	COG0298	carbon dioxide binding
AS145_09750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AS145_09760	COG1921	L-seryl-tRNASec selenium transferase activity
AS145_09765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AS145_09775	COG3260	NADH ubiquinone oxidoreductase 20
AS145_09780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_09785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AS145_09785	COG3261	NADH dehydrogenase
AS145_09790	COG0650	Formate hydrogenlyase subunit 4
AS145_09795	COG0651	ATP synthesis coupled electron transport
AS145_09800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_09805	COG3158	transport of potassium into the cell
AS145_09810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_09815	COG3383	formate dehydrogenase (NAD+) activity
AS145_09820	COG3383	formate dehydrogenase (NAD+) activity
AS145_09840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS145_09845	COG0326	Molecular chaperone. Has ATPase activity
AS145_09850	COG0563	adenylate kinase activity
AS145_09855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AS145_09865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS145_09885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS145_09905	COG1021	2,3-dihydroxybenzoate-AMP ligase
AS145_09910	COG3433	isochorismatase activity
AS145_09910	COG1535	isochorismatase
AS145_09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS145_09920	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS145_09935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS145_09940	COG2977	Belongs to the P-Pant transferase superfamily
AS145_09945	COG1120	ATPase activity
AS145_09950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS145_09955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS145_09960	COG4771	TonB-dependent receptor
AS145_09980	COG0598	Magnesium transport protein CorA
AS145_10000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AS145_10005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS145_10010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS145_10025	COG1570	exodeoxyribonuclease VII activity
AS145_10030	COG0697	spore germination
AS145_10050	COG3158	transport of potassium into the cell
AS145_10055	COG0517	IMP dehydrogenase activity
AS145_10055	COG0516	GMP reductase activity
AS145_10060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS145_10060	COG0519	Catalyzes the synthesis of GMP from XMP
AS145_10065	COG0582	viral genome integration into host DNA
AS145_10105	COG2169	Transcriptional regulator
AS145_10105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS145_10130	COG2062	phosphohistidine phosphatase, SixA
AS145_10140	COG0697	spore germination
AS145_10145	COG4166	transmembrane transport
AS145_10150	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AS145_10155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS145_10165	COG4591	ABC-type transport system involved in lipoprotein release permease component
AS145_10170	COG1136	(ABC) transporter
AS145_10175	COG4591	ABC-type transport system involved in lipoprotein release permease component
AS145_10180	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AS145_10190	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS145_10195	COG0740	serine-type endopeptidase activity
AS145_10200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AS145_10205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AS145_10215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS145_10220	COG0488	(ABC) transporter
AS145_10225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS145_10230	COG3162	membrane
AS145_10245	COG1024	Enoyl-CoA hydratase
AS145_10280	COG1115	amino acid carrier protein
AS145_10295	COG1584	GPR1 FUN34 yaaH family protein
AS145_10330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS145_10335	COG1960	acyl-CoA dehydrogenase activity
AS145_10345	COG1960	acyl-CoA dehydrogenase activity
AS145_10350	COG1024	Enoyl-CoA hydratase
AS145_10355	COG1024	Enoyl-CoA hydratase
AS145_10365	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_10375	COG0730	response to heat
AS145_10395	COG5002	protein histidine kinase activity
AS145_10395	COG5001	Diguanylate cyclase
AS145_10400	COG2003	Belongs to the UPF0758 family
AS145_10410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS145_10425	COG1073	alpha beta
AS145_10430	COG0823	Involved in the tonB-independent uptake of proteins
AS145_10430	COG1506	peptidase
AS145_10435	COG0702	epimerase
AS145_10440	COG0583	DNA-binding transcription factor activity
AS145_10445	COG0667	Aldo Keto reductase
AS145_10460	COG3706	GGDEF domain
AS145_10465	COG0583	DNA-binding transcription factor activity
AS145_10470	COG2723	6-phospho-beta-galactosidase activity
AS145_10475	COG5001	Diguanylate cyclase
AS145_10475	COG3300	MHYT domain
AS145_10485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AS145_10490	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_10495	COG0583	DNA-binding transcription factor activity
AS145_10500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AS145_10505	COG0673	inositol 2-dehydrogenase activity
AS145_10510	COG0583	DNA-binding transcription factor activity
AS145_10520	COG1560	Kdo2-lipid A biosynthetic process
AS145_10525	COG1560	Kdo2-lipid A biosynthetic process
AS145_10550	COG0417	DNA replication proofreading
AS145_10580	COG0534	Mate efflux family protein
AS145_10590	COG0307	riboflavin synthase, alpha
AS145_10600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS145_10605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AS145_10610	COG0697	spore germination
AS145_10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS145_10655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS145_10665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AS145_10670	COG2894	cell division
AS145_10675	COG0850	regulation of cytokinetic process
AS145_10680	COG3100	YcgL domain-containing protein
AS145_10685	COG2951	lytic endotransglycosylase activity
AS145_10690	COG1760	l-serine dehydratase
AS145_10695	COG1760	l-serine dehydratase
AS145_10700	COG3123	guanosine phosphorylase activity
AS145_10720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AS145_10740	COG1595	DNA-templated transcription, initiation
AS145_10770	COG0714	Associated with various cellular activities
AS145_10775	COG0183	Belongs to the thiolase family
AS145_10780	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS145_10780	COG1024	Enoyl-CoA hydratase
AS145_10785	COG4681	YaeQ
AS145_10805	COG4388	Caudovirus prohead serine protease
AS145_10815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS145_10820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS145_10825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS145_10835	COG0549	Belongs to the carbamate kinase family
AS145_10840	COG0697	spore germination
AS145_10845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AS145_10845	COG3608	succinylglutamate desuccinylase aspartoacylase
AS145_10850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS145_10860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_10860	COG0493	'glutamate synthase
AS145_10865	COG0402	S-adenosylhomocysteine deaminase activity
AS145_10870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AS145_10875	COG2080	2 iron, 2 sulfur cluster binding
AS145_10875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AS145_10880	COG2233	PERMEase
AS145_10885	COG0402	S-adenosylhomocysteine deaminase activity
AS145_10890	COG2252	PERMEase
AS145_10895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AS145_10900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AS145_10905	COG2080	2 iron, 2 sulfur cluster binding
AS145_10915	COG3134	Outer membrane lipoprotein
AS145_10925	COG1288	antiporter activity
AS145_10930	COG0318	PFAM AMP-dependent synthetase and ligase
AS145_10935	COG0140	phosphoribosyl-ATP diphosphatase activity
AS145_10935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS145_10940	COG0107	imidazoleglycerol-phosphate synthase activity
AS145_10945	COG2198	Histidine kinase
AS145_10945	COG0784	Response regulator, receiver
AS145_10945	COG2205	protein histidine kinase activity
AS145_10955	COG3437	response regulator, receiver
AS145_10960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AS145_10965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS145_10970	COG0131	Imidazoleglycerol-phosphate dehydratase
AS145_10970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AS145_10975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS145_10980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS145_10985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS145_10995	COG1199	ATP-dependent helicase activity
AS145_11000	COG1214	PFAM Peptidase M22, glycoprotease
AS145_11010	COG0596	Alpha beta hydrolase
AS145_11010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS145_11010	COG2226	methyltransferase
AS145_11015	COG0318	PFAM AMP-dependent synthetase and ligase
AS145_11020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AS145_11130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS145_11140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS145_11145	COG2832	Protein of unknown function (DUF454)
AS145_11150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS145_11160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AS145_11165	COG0582	viral genome integration into host DNA
AS145_11195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS145_11285	COG0753	catalase activity
AS145_11310	COG3646	Phage regulatory protein
AS145_11310	COG3645	SOS response
AS145_11335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS145_11340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS145_11355	COG2916	Histone family protein nucleoid-structuring protein H-NS
AS145_11515	COG1643	Atp-dependent helicase
AS145_11535	COG3437	response regulator, receiver
AS145_11540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS145_11545	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AS145_11550	COG0709	Synthesizes selenophosphate from selenide and ATP
AS145_11570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS145_11575	COG0840	transmembrane signaling receptor activity
AS145_11580	COG1254	Belongs to the acylphosphatase family
AS145_11585	COG0625	glutathione transferase activity
AS145_11590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS145_11590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS145_11595	COG0489	protein tyrosine kinase activity
AS145_11600	COG0572	uridine kinase
AS145_11605	COG0717	Belongs to the dCTP deaminase family
AS145_11610	COG0306	phosphate transporter
AS145_11615	COG1530	ribonuclease E activity
AS145_11620	COG0564	pseudouridine synthase activity
AS145_11630	COG0424	maF-like protein
AS145_11635	COG2814	Major facilitator Superfamily
AS145_11650	COG1399	metal-binding, possibly nucleic acid-binding protein
AS145_11655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS145_11660	COG0416	fatty acid biosynthetic process
AS145_11665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS145_11675	COG1028	Short-chain dehydrogenase reductase Sdr
AS145_11680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS145_11685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS145_11690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS145_11695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS145_11700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AS145_11705	COG0470	DNA polymerase III
AS145_11710	COG0084	hydrolase, TatD family'
AS145_11725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS145_11725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AS145_11730	COG3008	intermembrane lipid transfer
AS145_11735	COG2995	paraquat-inducible protein a
AS145_11745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS145_11750	COG0372	Belongs to the citrate synthase family
AS145_11795	COG4221	oxidoreductase activity
AS145_11805	COG3141	response to X-ray
AS145_11815	COG1067	ATP-dependent peptidase activity
AS145_11820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AS145_11830	COG0488	(ABC) transporter
AS145_11840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS145_11840	COG0116	Belongs to the methyltransferase superfamily
AS145_11850	COG0167	dihydroorotate dehydrogenase activity
AS145_11855	COG2902	Dehydrogenase
AS145_11865	COG0308	aminopeptidase N
AS145_11875	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AS145_11880	COG1956	GAF domain-containing protein
AS145_11890	COG3278	Belongs to the heme-copper respiratory oxidase family
AS145_11905	COG2010	Cytochrome c
AS145_11930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS145_11935	COG0589	response to stress
AS145_11940	COG0037	tRNA processing
AS145_11955	COG0625	glutathione transferase activity
AS145_11960	COG1869	D-ribose catabolic process
AS145_11965	COG1129	ABC transporter
AS145_11970	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS145_11975	COG1879	ABC-type sugar transport system periplasmic component
AS145_11980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS145_11985	COG1609	Transcriptional regulator
AS145_12000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS145_12020	COG0776	regulation of translation
AS145_12025	COG0072	phenylalanine-tRNA ligase activity
AS145_12025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS145_12030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AS145_12035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS145_12040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS145_12045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS145_12050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS145_12070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS145_12080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS145_12085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS145_12090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS145_12095	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AS145_12100	COG3313	Fe-S protein
AS145_12105	COG2942	2-epimerase
AS145_12110	COG3716	PTS system mannose fructose sorbose family IID component
AS145_12115	COG3715	PTS system
AS145_12120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_12120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_12135	COG1609	Transcriptional regulator
AS145_12140	COG2140	Oxalate decarboxylase
AS145_12145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_12145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_12145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AS145_12150	COG1105	Belongs to the carbohydrate kinase PfkB family
AS145_12155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_12155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_12160	COG1609	Transcriptional regulator
AS145_12165	COG0814	amino acid
AS145_12175	COG5654	RES domain protein
AS145_12180	COG0513	Belongs to the DEAD box helicase family
AS145_12190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS145_12195	COG2890	protein-(glutamine-N5) methyltransferase activity
AS145_12200	COG2840	Smr protein MutS2
AS145_12210	COG3706	GGDEF domain
AS145_12215	COG0588	phosphoglycerate mutase activity
AS145_12240	COG2824	Alkylphosphonate utilization operon protein PhnA
AS145_12255	COG0384	phenazine biosynthesis protein PhzF
AS145_12270	COG0242	peptide deformylase activity
AS145_12290	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AS145_12295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AS145_12305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS145_12310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AS145_12320	COG0205	6-phosphofructokinase activity
AS145_12325	COG1473	amidohydrolase
AS145_12330	COG1011	Hydrolase
AS145_12335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS145_12390	COG3593	DNA synthesis involved in DNA repair
AS145_12405	COG0583	DNA-binding transcription factor activity
AS145_12410	COG0730	response to heat
AS145_12425	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS145_12435	COG0386	Belongs to the glutathione peroxidase family
AS145_12440	COG0513	Belongs to the DEAD box helicase family
AS145_12445	COG0456	acetyltransferase
AS145_12455	COG1742	UPF0060 membrane protein
AS145_12485	COG2329	Antibiotic biosynthesis monooxygenase
AS145_12490	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AS145_12510	COG3243	poly(R)-hydroxyalkanoic acid synthase
AS145_12520	COG2501	S4 domain
AS145_12530	COG1132	(ABC) transporter
AS145_12535	COG1132	(ABC) transporter
AS145_12545	COG3118	belongs to the thioredoxin family
AS145_12550	COG0471	metal ion transport
AS145_12555	COG0058	SHG alpha-glucan phosphorylase activity
AS145_12590	COG0814	amino acid
AS145_12595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AS145_12600	COG0514	ATP-dependent DNA helicase (RecQ)
AS145_12605	COG2766	serine protein kinase
AS145_12615	COG2719	SpoVR family
AS145_12620	COG2186	Transcriptional regulator
AS145_12625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS145_12630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS145_12635	COG0586	Pfam SNARE associated Golgi protein
AS145_12645	COG0556	nucleotide-excision repair
AS145_12655	COG2985	domain, Protein
AS145_12655	COG0569	domain protein
AS145_12660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AS145_12680	COG4565	transcriptional regulatory protein
AS145_12685	COG3290	protein histidine kinase activity
AS145_12690	COG1846	Transcriptional regulator
AS145_12690	COG1940	carbohydrate kinase activity
AS145_12695	COG0840	transmembrane signaling receptor activity
AS145_12700	COG3012	SEC-C Motif Domain Protein
AS145_12705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS145_12710	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AS145_12715	COG0247	lactate metabolic process
AS145_12735	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AS145_12740	COG0437	4 iron, 4 sulfur cluster binding
AS145_12745	COG3301	Polysulphide reductase, NrfD
AS145_12750	COG1138	Cytochrome C-type biogenesis protein
AS145_12760	COG3088	subunit of a heme lyase
AS145_12760	COG4235	cytochrome complex assembly
AS145_12765	COG1051	belongs to the nudix hydrolase family
AS145_12775	COG3033	Beta-eliminating lyase
AS145_12780	COG3046	protein related to deoxyribodipyrimidine photolyase
AS145_12785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS145_12810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS145_12815	COG0583	DNA-binding transcription factor activity
AS145_12825	COG4774	siderophore transport
AS145_12830	COG4977	sequence-specific DNA binding
AS145_12840	COG0583	DNA-binding transcription factor activity
AS145_12845	COG2910	NAD(P)H-binding
AS145_12855	COG0626	cystathionine gamma-synthase activity
AS145_12860	COG0612	Peptidase, M16
AS145_12865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS145_12870	COG2076	Multidrug Resistance protein
AS145_12875	COG1944	ATP diphosphatase activity
AS145_12880	COG2116	formate transmembrane transporter activity
AS145_12885	COG1882	Formate acetyltransferase
AS145_12890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS145_12900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS145_12910	COG1840	ABC-type Fe3 transport system, periplasmic component
AS145_12915	COG3842	ATPase activity
AS145_12925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS145_12930	COG2983	Belongs to the UPF0260 family
AS145_12940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS145_12945	COG0045	succinate-CoA ligase (ADP-forming) activity
AS145_12950	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS145_12955	COG0567	Dehydrogenase, E1 component
AS145_12965	COG1053	succinate dehydrogenase
AS145_12970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AS145_12975	COG2009	succinate dehydrogenase
AS145_12995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS145_13000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AS145_13000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS145_13010	COG3069	C4-dicarboxylate transmembrane transporter activity
AS145_13025	COG1451	nucleotide metabolic process
AS145_13040	COG0254	rRNA binding
AS145_13045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS145_13055	COG0583	DNA-binding transcription factor activity
AS145_13065	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS145_13075	COG1879	ABC-type sugar transport system periplasmic component
AS145_13080	COG1069	ribulokinase activity
AS145_13090	COG2160	L-arabinose isomerase activity
AS145_13095	COG2925	Exonuclease
AS145_13105	COG3345	alpha-galactosidase
AS145_13110	COG1380	Effector of murein hydrolase LrgA
AS145_13115	COG1346	cytolysis
AS145_13120	COG0295	cytidine deaminase activity
AS145_13125	COG1022	Amp-dependent synthetase and ligase
AS145_13140	COG0861	Integral membrane protein TerC family
AS145_13145	COG2885	chlorophyll binding
AS145_13150	COG2199	diguanylate cyclase activity
AS145_13165	COG2154	pterin-4-alpha-carbinolamine dehydratase
AS145_13170	COG2154	pterin-4-alpha-carbinolamine dehydratase
AS145_13180	COG3768	UPF0283 membrane protein
AS145_13185	COG3106	COG3106 Predicted ATPase
AS145_13200	COG1842	Phage shock protein A
AS145_13205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AS145_13215	COG4168	peptide transport system, permease
AS145_13220	COG4171	peptide transport system, permease
AS145_13230	COG4172	Belongs to the ABC transporter superfamily
AS145_13240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AS145_13245	COG1286	toxin biosynthetic process
AS145_13250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AS145_13260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS145_13265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS145_13270	COG0531	amino acid
AS145_13270	COG1674	ftsk spoiiie
AS145_13280	COG0492	ferredoxin-NADP+ reductase activity
AS145_13285	COG3706	GGDEF domain
AS145_13290	COG3134	Outer membrane lipoprotein
AS145_13295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AS145_13300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AS145_13305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS145_13310	COG0542	response to heat
AS145_13315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AS145_13320	COG1278	Cold shock
AS145_13325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AS145_13355	COG3501	Rhs element vgr protein
AS145_13460	COG3501	Rhs element vgr protein
AS145_13485	COG1435	thymidine kinase activity
AS145_13490	COG1757	Na H antiporter
AS145_13495	COG2916	Histone family protein nucleoid-structuring protein H-NS
AS145_13500	COG2096	Adenosyltransferase
AS145_13505	COG3530	Putative quorum-sensing-regulated virulence factor
AS145_13510	COG0602	queuosine metabolic process
AS145_13515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS145_13535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AS145_13545	COG0776	regulation of translation
AS145_13550	COG0539	negative regulation of cytoplasmic translation
AS145_13555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS145_13560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS145_13570	COG0583	DNA-binding transcription factor activity
AS145_13590	COG0778	Nitroreductase
AS145_13595	COG5001	Diguanylate cyclase
AS145_13595	COG3300	MHYT domain
AS145_13605	COG0583	DNA-binding transcription factor activity
AS145_13610	COG3437	response regulator, receiver
AS145_13635	COG4989	oxidoreductase activity
AS145_13640	COG0724	RNA recognition motif
AS145_13660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AS145_13675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS145_13680	COG1360	Flagellar Motor Protein
AS145_13685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_13690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_13695	COG0649	NAD binding
AS145_13695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_13710	COG1034	ATP synthesis coupled electron transport
AS145_13715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AS145_13720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_13725	COG0839	Belongs to the complex I subunit 6 family
AS145_13730	COG0713	ATP synthesis coupled electron transport
AS145_13740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS145_13745	COG1007	ATP synthesis coupled electron transport
AS145_13755	COG0047	phosphoribosylformylglycinamidine synthase activity
AS145_13755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS145_13760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AS145_13765	COG1645	bacterial-type flagellum-dependent swarming motility
AS145_13770	COG1160	GTP binding
AS145_13775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS145_13780	COG2976	Protein conserved in bacteria
AS145_13785	COG0124	histidyl-tRNA synthetase
AS145_13790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AS145_13805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AS145_13810	COG0105	UTP biosynthetic process
AS145_13815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS145_13825	COG0633	Ferredoxin
AS145_13830	COG0443	Heat shock 70 kDa protein
AS145_13835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AS145_13845	COG0822	iron-sulfur transferase activity
AS145_13850	COG1104	cysteine desulfurase activity
AS145_13895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS145_13900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS145_13905	COG1862	Preprotein translocase
AS145_13910	COG0343	queuine tRNA-ribosyltransferase activity
AS145_13915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AS145_13920	COG0517	IMP dehydrogenase activity
AS145_13925	COG0450	alkyl hydroperoxide reductase
AS145_13930	COG3634	alkyl hydroperoxide reductase activity
AS145_13935	COG2814	Major facilitator Superfamily
AS145_13950	COG1393	Belongs to the ArsC family
AS145_13955	COG0798	PFAM Bile acid sodium symporter
AS145_13960	COG0640	Transcriptional regulator
AS145_13965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS145_13965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS145_13970	COG0509	glycine decarboxylation via glycine cleavage system
AS145_13975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS145_13980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS145_13985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS145_14000	COG2814	Major facilitator Superfamily
AS145_14005	COG0625	glutathione transferase activity
AS145_14015	COG0483	inositol monophosphate 1-phosphatase activity
AS145_14035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS145_14050	COG1086	Polysaccharide biosynthesis protein
AS145_14070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS145_14085	COG2089	acid synthase
AS145_14155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS145_14155	COG0301	tRNA thio-modification
AS145_14165	COG4953	penicillin-binding protein 1C
AS145_14170	COG2373	Large extracellular alpha-helical protein
AS145_14175	COG1473	amidohydrolase
AS145_14180	COG0628	permease
AS145_14185	COG1538	Outer membrane efflux protein
AS145_14190	COG1566	PFAM secretion protein HlyD family protein
AS145_14205	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS145_14215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS145_14230	COG4215	(ABC) transporter
AS145_14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_14245	COG2431	L-lysine efflux transmembrane transporter activity
AS145_14250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS145_14255	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AS145_14270	COG1393	Belongs to the ArsC family
AS145_14280	COG4783	chaperone-mediated protein folding
AS145_14285	COG0425	Belongs to the sulfur carrier protein TusA family
AS145_14310	COG3842	ATPase activity
AS145_14320	COG1175	transmembrane transport
AS145_14330	COG3081	Nucleoid-associated protein
AS145_14335	COG3082	Protein of unknown function (DUF1414)
AS145_14340	COG3083	sulfuric ester hydrolase activity
AS145_14345	COG4771	TonB-dependent receptor
AS145_14350	COG1770	oligopeptidase
AS145_14370	COG4574	serine-type endopeptidase inhibitor activity
AS145_14375	COG3085	chromosome segregation
AS145_14380	COG0583	DNA-binding transcription factor activity
AS145_14385	COG0287	Prephenate dehydrogenase
AS145_14385	COG1605	Chorismate mutase
AS145_14390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS145_14395	COG0584	glycerophosphoryl diester phosphodiesterase
AS145_14405	COG1349	DNA-binding transcription factor activity
AS145_14410	COG2271	Major facilitator Superfamily
AS145_14415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS145_14420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AS145_14425	COG0583	DNA-binding transcription factor activity
AS145_14445	COG0656	L-ascorbic acid biosynthetic process
AS145_14450	COG2814	Major facilitator Superfamily
AS145_14460	COG1294	oxidase, subunit
AS145_14470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS145_14480	COG2979	Protein of unknown function (DUF533)
AS145_14500	COG2271	Major facilitator Superfamily
AS145_14505	COG0583	DNA-binding transcription factor activity
AS145_14515	COG2807	transmembrane transport
AS145_14520	COG1187	pseudouridine synthase activity
AS145_14545	COG1061	Type III restriction enzyme res subunit
AS145_14555	COG2964	Protein conserved in bacteria
AS145_14560	COG3681	Belongs to the UPF0597 family
AS145_14570	COG0814	amino acid
AS145_14590	COG1166	arginine decarboxylase activity
AS145_14595	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS145_14625	COG0583	DNA-binding transcription factor activity
AS145_14635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AS145_14640	COG0840	transmembrane signaling receptor activity
AS145_14645	COG0302	gtp cyclohydrolase
AS145_14655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS145_14660	COG2267	carboxylic ester hydrolase activity
AS145_14665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AS145_14680	COG0314	molybdopterin synthase activity
AS145_14685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AS145_14690	COG0315	cyclic pyranopterin monophosphate synthase activity
AS145_14695	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS145_14700	COG3005	denitrification pathway
AS145_14710	COG0348	domain, Protein
AS145_14715	COG0437	4 iron, 4 sulfur cluster binding
AS145_14720	COG0243	molybdopterin cofactor binding
AS145_14730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_14730	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_14735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS145_14740	COG3850	Histidine kinase
AS145_14745	COG2197	response regulator
AS145_14775	COG0121	glutamine amidotransferase
AS145_14780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AS145_14785	COG1960	acyl-CoA dehydrogenase activity
AS145_14790	COG3437	response regulator, receiver
AS145_14790	COG0784	Response regulator, receiver
AS145_14800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS145_14805	COG0328	RNA-DNA hybrid ribonuclease activity
AS145_14810	COG2226	methyltransferase
AS145_14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS145_14820	COG1388	LysM domain
AS145_14820	COG0741	lytic transglycosylase activity
AS145_14825	COG3021	interspecies interaction between organisms
AS145_14835	COG1607	acyl-coa hydrolase
AS145_14850	COG0741	lytic transglycosylase activity
AS145_14860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS145_14885	COG0729	surface antigen
AS145_14895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS145_14900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS145_14910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS145_14920	COG4134	Bacterial extracellular solute-binding protein
AS145_14930	COG4136	ATPase activity
AS145_14935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS145_14940	COG2951	lytic endotransglycosylase activity
AS145_14945	COG1846	Transcriptional regulator
AS145_14955	COG0033	Phosphoglucomutase
AS145_14960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AS145_14965	COG0596	Alpha beta hydrolase
AS145_14980	COG0716	FMN binding
AS145_14990	COG0735	belongs to the Fur family
AS145_14995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS145_15005	COG2190	(PTS) system
AS145_15005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_15005	COG1263	PTS System
AS145_15010	COG0363	glucosamine-6-phosphate deaminase activity
AS145_15015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS145_15020	COG1940	carbohydrate kinase activity
AS145_15020	COG1846	Transcriptional regulator
AS145_15025	COG2194	sulfuric ester hydrolase activity
AS145_15030	COG0217	transcriptional regulatory protein
AS145_15035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS145_15040	COG1801	Protein of unknown function DUF72
AS145_15045	COG4106	trans-aconitate 2-methyltransferase activity
AS145_15050	COG0500	methyltransferase
AS145_15070	COG0450	alkyl hydroperoxide reductase
AS145_15075	COG0583	DNA-binding transcription factor activity
AS145_15085	COG0791	NLP P60 protein
AS145_15100	COG1309	transcriptional regulator
AS145_15140	COG0534	Mate efflux family protein
AS145_15160	COG2366	antibiotic biosynthetic process
AS145_15165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS145_15165	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS145_15165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AS145_15165	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS145_15175	COG0633	Ferredoxin
AS145_15175	COG3217	Mosc domain protein beta barrel domain protein
AS145_15175	COG0633	Ferredoxin
AS145_15175	COG3217	Mosc domain protein beta barrel domain protein
AS145_15185	COG0501	Belongs to the peptidase M48B family
AS145_15190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AS145_15195	COG1073	alpha beta
AS145_15195	COG2226	methyltransferase
AS145_15200	COG0156	8-amino-7-oxononanoate synthase activity
AS145_15205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AS145_15225	COG0017	Asparaginyl-tRNA synthetase
AS145_15230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AS145_15245	COG3069	C4-dicarboxylate transmembrane transporter activity
AS145_15255	COG0583	DNA-binding transcription factor activity
AS145_15260	COG1393	Belongs to the ArsC family
AS145_15265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS145_15270	COG1876	peptidase activity
AS145_15275	COG3263	regulation of cellular component size
AS145_15295	COG1280	lysine exporter protein (LysE YggA)
AS145_15320	COG1957	nucleoside hydrolase
AS145_15325	COG0564	pseudouridine synthase activity
AS145_15335	COG1454	alcohol dehydrogenase
AS145_15385	COG4964	Belongs to the GSP D family
AS145_15415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS145_15420	COG0702	epimerase
AS145_15430	COG2867	negative regulation of translational initiation
AS145_15435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS145_15515	COG4397	Mu-like prophage major head subunit gpT
AS145_15520	COG4388	Caudovirus prohead serine protease
AS145_15540	COG4383	Mu-like prophage protein gp29
AS145_15545	COG4373	Mu-like prophage FluMu protein gp28
AS145_15555	COG0640	Transcriptional regulator
AS145_15590	COG5566	PFAM Mor transcription activator
AS145_15695	COG0583	DNA-binding transcription factor activity
AS145_15700	COG2610	gluconate transmembrane transporter activity
AS145_15705	COG3048	D-serine ammonia-lyase activity
AS145_15710	COG0538	isocitrate dehydrogenase activity
AS145_15715	COG2207	Transcriptional regulator
AS145_15730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_15740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS145_15745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_15745	COG1263	PTS System
AS145_15750	COG1609	Transcriptional regulator
AS145_15765	COG0456	acetyltransferase
AS145_15785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_15785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_15785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_15795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS145_15805	COG1187	pseudouridine synthase activity
AS145_15815	COG0482	sulfurtransferase activity
AS145_15820	COG2915	High frequency lysogenization protein hflD homolog
AS145_15825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS145_15830	COG2850	peptidyl-arginine hydroxylation
AS145_15840	COG3153	acetyltransferase
AS145_15850	COG0625	glutathione transferase activity
AS145_15855	COG0259	pyridoxamine-phosphate oxidase activity
AS145_15870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS145_15870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS145_15875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AS145_15890	COG3088	subunit of a heme lyase
AS145_15890	COG4235	cytochrome complex assembly
AS145_15895	COG3088	subunit of a heme lyase
AS145_15895	COG4235	cytochrome complex assembly
AS145_15900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS145_15905	COG1138	Cytochrome C-type biogenesis protein
AS145_15910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AS145_15915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS145_15920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS145_15925	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS145_15940	COG0835	chemotaxis
AS145_15950	COG1192	Involved in chromosome partitioning
AS145_15955	COG1360	Flagellar Motor Protein
AS145_15960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS145_15965	COG2201	protein-glutamate methylesterase activity
AS145_15970	COG0643	Histidine kinase
AS145_15970	COG2198	Histidine kinase
AS145_15975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AS145_15990	COG0455	bacterial-type flagellum organization
AS145_16000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS145_16010	COG1684	flagellar biosynthetic protein fliR
AS145_16015	COG1987	bacterial-type flagellum assembly
AS145_16065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS145_16075	COG1677	Flagellar hook-basal body complex protein FliE
AS145_16090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS145_16100	COG3064	Membrane
AS145_16100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AS145_16100	COG1073	alpha beta
AS145_16115	COG2274	protein secretion by the type I secretion system
AS145_16125	COG2274	protein secretion by the type I secretion system
AS145_16130	COG0745	RESPONSE REGULATOR receiver
AS145_16145	COG1737	Transcriptional regulator
AS145_16150	COG0469	pyruvate kinase activity
AS145_16160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS145_16165	COG1960	acyl-CoA dehydrogenase activity
AS145_16175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS145_16185	COG0243	molybdopterin cofactor binding
AS145_16190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS145_16195	COG0583	DNA-binding transcription factor activity
AS145_16215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AS145_16220	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AS145_16225	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AS145_16230	COG1012	belongs to the aldehyde dehydrogenase family
AS145_16230	COG1454	alcohol dehydrogenase
AS145_16240	COG1454	alcohol dehydrogenase
AS145_16240	COG1012	belongs to the aldehyde dehydrogenase family
AS145_16245	COG1882	Formate acetyltransferase
AS145_16250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS145_16255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AS145_16260	COG4869	propanediol catabolic process
AS145_16305	COG2731	YhcH YjgK YiaL family protein
AS145_16310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS145_16320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AS145_16325	COG1737	Transcriptional regulator
AS145_16330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS145_16335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AS145_16340	COG1349	DNA-binding transcription factor activity
AS145_16345	COG0738	Major facilitator superfamily
AS145_16355	COG1070	Carbohydrate kinase
AS145_16375	COG4172	Belongs to the ABC transporter superfamily
AS145_16380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS145_16390	COG0747	negative chemotaxis
AS145_16400	COG1388	LysM domain
AS145_16400	COG1376	ErfK ybiS ycfS ynhG family protein
AS145_16415	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AS145_16420	COG0791	NLP P60 protein
AS145_16425	COG2091	lysine biosynthetic process via aminoadipic acid
AS145_16430	COG3118	belongs to the thioredoxin family
AS145_16440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS145_16445	COG0788	formyltetrahydrofolate deformylase activity
AS145_16455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS145_16475	COG0366	Alpha amylase catalytic
AS145_16480	COG1196	nuclear chromosome segregation
AS145_16480	COG0741	lytic transglycosylase activity
AS145_16480	COG0739	heme binding
AS145_16485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS145_16490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AS145_16500	COG0673	inositol 2-dehydrogenase activity
AS145_16520	COG1032	radical SAM domain protein
AS145_16530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS145_16535	COG1566	PFAM secretion protein HlyD family protein
AS145_16540	COG2199	diguanylate cyclase activity
AS145_16540	COG2203	Gaf domain
AS145_16545	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS145_16550	COG0733	neurotransmitter:sodium symporter activity
AS145_16580	COG0281	malic enzyme
AS145_16590	COG0534	Mate efflux family protein
AS145_16600	COG0745	RESPONSE REGULATOR receiver
AS145_16600	COG3706	GGDEF domain
AS145_16605	COG2233	PERMEase
AS145_16610	COG0095	Lipoate-protein ligase
AS145_16615	COG1115	amino acid carrier protein
AS145_16620	COG0019	diaminopimelate decarboxylase activity
AS145_16630	COG0678	peroxiredoxin activity
AS145_16640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AS145_16660	COG1131	(ABC) transporter
AS145_16665	COG0545	Peptidyl-prolyl cis-trans isomerase
AS145_16670	COG3142	Participates in the control of copper homeostasis
AS145_16685	COG4783	chaperone-mediated protein folding
AS145_16695	COG5002	protein histidine kinase activity
AS145_16700	COG0745	RESPONSE REGULATOR receiver
AS145_16705	COG0346	lactoylglutathione lyase activity
AS145_16710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS145_16715	COG1960	acyl-CoA dehydrogenase activity
AS145_16720	COG3284	Transcriptional regulator
AS145_16725	COG1012	belongs to the aldehyde dehydrogenase family
AS145_16735	COG0697	spore germination
AS145_16740	COG4565	transcriptional regulatory protein
AS145_16745	COG3290	protein histidine kinase activity
AS145_16750	COG0281	malic enzyme
AS145_16760	COG1846	Transcriptional regulator
AS145_16765	COG1566	PFAM secretion protein HlyD family protein
AS145_16790	COG0602	queuosine metabolic process
AS145_16795	COG1328	CTP reductase activity
AS145_16805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS145_16810	COG3115	cell septum assembly
AS145_16815	COG1196	nuclear chromosome segregation
AS145_16825	COG2860	membrane
AS145_16835	COG3108	Peptidase M15
AS145_16840	COG2989	Protein conserved in bacteria
AS145_16855	COG0463	Glycosyl transferase, family 2
AS145_16870	COG0366	Alpha amylase catalytic
AS145_16905	COG3706	GGDEF domain
AS145_16910	COG0037	tRNA processing
AS145_16915	COG3590	peptidase
AS145_16925	COG0488	(ABC) transporter
AS145_16935	COG0531	amino acid
AS145_16950	COG0814	amino acid
AS145_16965	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AS145_16970	COG1982	Orn Lys Arg decarboxylase major
AS145_16975	COG0531	amino acid
AS145_16980	COG3710	Transcriptional regulator
AS145_16985	COG0825	malonyl-CoA metabolic process
AS145_16995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS145_17000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS145_17005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS145_17010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AS145_17015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS145_17030	COG0750	zinc metalloprotease
AS145_17035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AS145_17040	COG0575	Belongs to the CDS family
AS145_17050	COG0233	cytoplasmic translational termination
AS145_17055	COG0528	UMP kinase activity
AS145_17060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS145_17065	COG0052	Belongs to the universal ribosomal protein uS2 family
AS145_17070	COG0024	Methionine aminopeptidase
AS145_17075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AS145_17080	COG2171	N-acyltransferase activity
AS145_17090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_17090	COG1263	PTS System
AS145_17100	COG4580	involved in the transport of maltose and maltodextrins
AS145_17110	COG0564	pseudouridine synthase activity
AS145_17115	COG3098	single-species biofilm formation
AS145_17140	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AS145_17150	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AS145_17150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AS145_17160	COG3706	GGDEF domain
AS145_17165	COG1611	Belongs to the LOG family
AS145_17170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS145_17175	COG0473	3-isopropylmalate dehydrogenase activity
AS145_17185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AS145_17190	COG2363	Small membrane protein
AS145_17200	COG0583	DNA-binding transcription factor activity
AS145_17205	COG0840	transmembrane signaling receptor activity
AS145_17210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS145_17225	COG1477	protein flavinylation
AS145_17230	COG2871	sodium ion transport
AS145_17235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AS145_17240	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AS145_17245	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AS145_17250	COG1805	sodium ion transport
AS145_17255	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AS145_17260	COG0271	Belongs to the BolA IbaG family
AS145_17265	COG2813	Specifically methylates the guanine in position
AS145_17275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS145_17285	COG2211	Major facilitator Superfamily
AS145_17290	COG3248	Nucleoside-binding outer membrane protein
AS145_17295	COG1666	GTP binding
AS145_17300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS145_17305	COG0693	protein deglycase activity
AS145_17350	COG2771	luxR family
AS145_17360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS145_17360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS145_17365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS145_17375	COG1151	hydroxylamine reductase activity
AS145_17380	COG0783	Belongs to the Dps family
AS145_17405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AS145_17420	COG4221	oxidoreductase activity
AS145_17430	COG0415	Belongs to the DNA photolyase family
AS145_17435	COG0789	Transcriptional regulator
AS145_17440	COG3272	Protein of unknown function (DUF1722)
AS145_17470	COG1605	Chorismate mutase
AS145_17470	COG0077	Prephenate dehydratase
AS145_17500	COG5377	YqaJ viral recombinase family
AS145_17540	COG2003	Belongs to the UPF0758 family
AS145_17550	COG0602	queuosine metabolic process
AS145_17555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS145_17570	COG0720	synthase
AS145_17605	COG0514	ATP-dependent DNA helicase (RecQ)
AS145_17610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS145_17635	COG4771	TonB-dependent receptor
AS145_17695	COG2226	methyltransferase
AS145_17720	COG2133	pyrroloquinoline quinone binding
AS145_17730	COG0840	transmembrane signaling receptor activity
AS145_17740	COG0300	oxidoreductase activity
AS145_17760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS145_17775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS145_17780	COG0826	peptidase U32
AS145_17785	COG1280	lysine exporter protein (LysE YggA)
AS145_17800	COG0840	transmembrane signaling receptor activity
AS145_17805	COG0745	RESPONSE REGULATOR receiver
AS145_17815	COG2198	Histidine kinase
AS145_17815	COG0643	Histidine kinase
AS145_17825	COG0835	chemotaxis
AS145_17830	COG0840	transmembrane signaling receptor activity
AS145_17840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AS145_17845	COG2201	protein-glutamate methylesterase activity
AS145_17850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS145_17890	COG2199	diguanylate cyclase activity
AS145_17890	COG2200	EAL domain
AS145_17890	COG2203	Gaf domain
AS145_17900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS145_17905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS145_17910	COG0305	Participates in initiation and elongation during chromosome replication
AS145_17920	COG2200	EAL domain
AS145_17925	COG0737	Belongs to the 5'-nucleotidase family
AS145_17945	COG2204	response regulator
AS145_17950	COG0545	Peptidyl-prolyl cis-trans isomerase
AS145_17960	COG2900	Belongs to the SlyX family
AS145_17965	COG1047	Peptidyl-prolyl cis-trans
AS145_17970	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AS145_17980	COG0835	chemotaxis
AS145_17980	COG0784	Response regulator, receiver
AS145_17985	COG0429	hydrolase of the alpha beta-hydrolase fold
AS145_17990	COG5001	Diguanylate cyclase
AS145_17990	COG4251	negative regulation of phosphorylation
AS145_17990	COG2203	Gaf domain
AS145_17990	COG3706	GGDEF domain
AS145_17995	COG3089	Belongs to the UPF0270 family
AS145_18005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS145_18010	COG0463	Glycosyl transferase, family 2
AS145_18015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS145_18015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS145_18020	COG0726	polysaccharide deacetylase
AS145_18025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AS145_18030	COG2076	Multidrug Resistance protein
AS145_18035	COG2076	Multidrug Resistance protein
AS145_18040	COG3954	Phosphoribulokinase
AS145_18055	COG1765	OsmC-like protein
AS145_18060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS145_18065	COG2226	methyltransferase
AS145_18070	COG3397	chitin binding
AS145_18085	COG2205	protein histidine kinase activity
AS145_18085	COG2202	Pas domain
AS145_18095	COG3655	Transcriptional regulator
AS145_18100	COG2814	Major facilitator Superfamily
AS145_18105	COG4771	TonB-dependent receptor
AS145_18125	COG0748	coenzyme F420 binding
AS145_18130	COG3721	Heme iron utilization protein
AS145_18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS145_18165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS145_18170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS145_18175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AS145_18195	COG0741	lytic transglycosylase activity
AS145_18200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS145_18295	COG0616	signal peptide processing
AS145_18310	COG4626	Terminase
AS145_18310	COG1802	Transcriptional regulator
AS145_18355	COG0464	growth
AS145_18480	COG0582	viral genome integration into host DNA
AS145_18485	COG0488	(ABC) transporter
AS145_18495	COG2252	PERMEase
AS145_18500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AS145_18505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS145_18515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AS145_18525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AS145_18530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS145_18540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS145_18550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS145_18555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AS145_18570	COG0318	PFAM AMP-dependent synthetase and ligase
AS145_18580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS145_18585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AS145_18595	COG0142	geranyltranstransferase activity
AS145_18600	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AS145_18605	COG0330	HflC and HflK could
AS145_18610	COG0330	HflC and HflK could
AS145_18615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS145_18620	COG1923	regulation of RNA biosynthetic process
AS145_18625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AS145_18630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AS145_18640	COG0802	atpase or kinase
AS145_18645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS145_18645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS145_18670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS145_18675	COG2011	ABC-type metal ion transport system permease component
AS145_18680	COG1464	Belongs to the NlpA lipoprotein family
AS145_18690	COG0840	transmembrane signaling receptor activity
AS145_18715	COG5002	protein histidine kinase activity
AS145_18715	COG2198	Histidine kinase
AS145_18715	COG0784	Response regulator, receiver
AS145_18735	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AS145_18750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AS145_18755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AS145_18765	COG2716	regulation of RNA biosynthetic process
AS145_18770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS145_18775	COG3013	Belongs to the UPF0304 family
AS145_18780	COG3092	negative regulation of chromosome organization
AS145_18785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS145_18790	COG0280	phosphate acetyltransferase
AS145_18790	COG0857	belongs to the CobB CobQ family
AS145_18800	COG0028	Belongs to the TPP enzyme family
AS145_18810	COG0671	phosphoesterase, PA-phosphatase related
AS145_18820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS145_18825	COG0473	3-isopropylmalate dehydrogenase activity
AS145_18830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS145_18835	COG0066	3-isopropylmalate dehydratase activity
AS145_18850	COG4143	(ABC) transporter
AS145_18855	COG1178	ABC-type Fe3 transport system permease component
AS145_18860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AS145_18865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS145_18875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS145_18905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS145_18910	COG0564	pseudouridine synthase activity
AS145_18920	COG5001	Diguanylate cyclase
AS145_18920	COG3300	MHYT domain
AS145_18930	COG0459	protein refolding
AS145_18935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AS145_18940	COG0534	Mate efflux family protein
AS145_18945	COG3030	protein affecting phage T7 exclusion by the F plasmid
AS145_18950	COG1027	Aspartate ammonia-lyase
AS145_18955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AS145_18965	COG0477	Major facilitator Superfamily
AS145_18985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS145_18995	COG0673	inositol 2-dehydrogenase activity
AS145_19005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS145_19010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS145_19015	COG3036	rescue of stalled ribosome
AS145_19020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS145_19030	COG0138	bifunctional purine biosynthesis protein purh
AS145_19035	COG0151	Belongs to the GarS family
AS145_19065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS145_19070	COG0358	DNA primase activity
AS145_19075	COG1610	YqeY-like protein
AS145_19080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AS145_19090	COG4942	peptidase
AS145_19090	COG1388	LysM domain
AS145_19095	COG1238	metal cluster binding
AS145_19100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AS145_19105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AS145_19110	COG0585	pseudouridine synthase activity
AS145_19120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AS145_19125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AS145_19130	COG0148	phosphopyruvate hydratase activity
AS145_19135	COG0504	CTP synthase activity
AS145_19140	COG3956	TIGRFAM MazG family protein
AS145_19145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS145_19150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS145_19160	COG4807	Protein conserved in bacteria
AS145_19165	COG3023	N-Acetylmuramoyl-L-alanine amidase
AS145_19170	COG1349	DNA-binding transcription factor activity
AS145_19180	COG2222	sugar isomerase
AS145_19185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_19195	COG3716	PTS system mannose fructose sorbose family IID component
AS145_19200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_19205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS145_19220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AS145_19225	COG1381	Involved in DNA repair and RecF pathway recombination
AS145_19235	COG0571	ribonuclease III activity
AS145_19240	COG0681	Belongs to the peptidase S26 family
AS145_19245	COG0481	GTPase activity
AS145_19260	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AS145_19265	COG1595	DNA-templated transcription, initiation
AS145_19270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS145_19280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AS145_19285	COG0354	folic acid binding
AS145_19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS145_19325	COG0191	fructose-bisphosphate aldolase activity
AS145_19330	COG0126	phosphoglycerate kinase activity
AS145_19335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS145_19340	COG1940	carbohydrate kinase activity
AS145_19345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS145_19360	COG4991	sh3 domain protein
AS145_19365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS145_19380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AS145_19400	COG1505	serine-type exopeptidase activity
AS145_19405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS145_19410	COG0765	amino acid transport
AS145_19415	COG0765	amino acid transport
AS145_19420	COG1126	abc transporter atp-binding protein
AS145_19425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_19430	COG0577	efflux transmembrane transporter activity
AS145_19430	COG1136	(ABC) transporter
AS145_19435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS145_19440	COG0745	RESPONSE REGULATOR receiver
AS145_19445	COG2205	protein histidine kinase activity
AS145_19485	COG2070	2-Nitropropane dioxygenase
AS145_19510	COG1858	cytochrome C peroxidase
AS145_19515	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AS145_19535	COG0513	Belongs to the DEAD box helicase family
AS145_19550	COG0154	amidase activity
AS145_19555	COG2957	Belongs to the agmatine deiminase family
AS145_19570	COG1902	pentaerythritol trinitrate reductase activity
AS145_19600	COG0745	RESPONSE REGULATOR receiver
AS145_19600	COG3706	GGDEF domain
AS145_19605	COG5001	Diguanylate cyclase
AS145_19615	COG0714	Associated with various cellular activities
AS145_19625	COG0456	acetyltransferase
AS145_19635	COG1022	Amp-dependent synthetase and ligase
AS145_19645	COG2918	glutathione biosynthetic process
AS145_19650	COG0612	Peptidase, M16
AS145_19655	COG1238	metal cluster binding
AS145_19675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS145_19680	COG0359	binds to the 23S rRNA
AS145_19685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS145_19690	COG0360	Binds together with S18 to 16S ribosomal RNA
AS145_19695	COG1914	H( )-stimulated, divalent metal cation uptake system
AS145_19715	COG2153	protein acetylation
AS145_19725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS145_19730	COG0557	exoribonuclease II activity
AS145_19735	COG3706	GGDEF domain
AS145_19740	COG1854	S-ribosylhomocysteine lyase activity
AS145_19755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS145_19755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AS145_19815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AS145_19820	COG1047	Peptidyl-prolyl cis-trans
AS145_19825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS145_19830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS145_19835	COG0196	riboflavin kinase activity
AS145_19840	COG0728	peptidoglycan biosynthetic process
AS145_19845	COG0268	Binds directly to 16S ribosomal RNA
AS145_19850	COG0640	Transcriptional regulator
AS145_19855	COG0583	DNA-binding transcription factor activity
AS145_19865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS145_19870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS145_19875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AS145_19885	COG1051	belongs to the nudix hydrolase family
AS145_19890	COG3066	DNA modification
AS145_19900	COG0335	large ribosomal subunit rRNA binding
AS145_19905	COG0336	Belongs to the RNA methyltransferase TrmD family
AS145_19910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS145_19915	COG0228	four-way junction DNA binding
AS145_19920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS145_19925	COG4137	Cytochrome C assembly protein
AS145_19930	COG4536	flavin adenine dinucleotide binding
AS145_19940	COG1017	nitric oxide dioxygenase activity
AS145_19940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS145_19945	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AS145_19950	COG0039	L-malate dehydrogenase activity
AS145_19955	COG4160	amino acid transport
AS145_19960	COG4215	(ABC) transporter
AS145_19965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS145_19970	COG1126	abc transporter atp-binding protein
AS145_19975	COG1438	arginine binding
AS145_19980	COG2837	iron assimilation
AS145_19985	COG3842	ATPase activity
AS145_19995	COG1840	ABC-type Fe3 transport system, periplasmic component
AS145_20000	COG0347	Belongs to the P(II) protein family
AS145_20015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS145_20020	COG0583	DNA-binding transcription factor activity
AS145_20035	COG1929	Belongs to the glycerate kinase type-1 family
AS145_20040	COG2610	gluconate transmembrane transporter activity
AS145_20045	COG3835	regulator
AS145_20050	COG3112	Uncharacterised protein family (UPF0231)
AS145_20065	COG0840	transmembrane signaling receptor activity
AS145_20070	COG3568	Endonuclease Exonuclease Phosphatase
AS145_20085	COG0513	Belongs to the DEAD box helicase family
AS145_20125	COG1448	Aminotransferase
AS145_20140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS145_20145	COG1328	CTP reductase activity
AS145_20165	COG4946	Tricorn protease homolog
AS145_20165	COG0793	Belongs to the peptidase S41A family
AS145_20195	COG0840	transmembrane signaling receptor activity
AS145_20200	COG3397	chitin binding
AS145_20205	COG0583	DNA-binding transcription factor activity
AS145_20210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS145_20215	COG4208	sulfate ABC transporter
AS145_20220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AS145_20230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS145_20235	COG3174	membrane
AS145_20240	COG0110	maltose O-acetyltransferase activity
AS145_20265	COG0165	Argininosuccinate lyase
AS145_20270	COG0137	argininosuccinate synthase activity
AS145_20280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS145_20285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AS145_20295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS145_20305	COG0460	homoserine dehydrogenase
AS145_20305	COG0527	aspartate kinase activity
AS145_20310	COG0626	cystathionine gamma-synthase activity
AS145_20320	COG3708	Transcriptional regulator
AS145_20320	COG2207	Transcriptional regulator
AS145_20325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS145_20330	COG0814	amino acid
AS145_20335	COG1218	3'(2'),5'-bisphosphate nucleotidase
AS145_20340	COG0494	nUDIX hydrolase
AS145_20345	COG1011	Hydrolase
AS145_20350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS145_20365	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AS145_20375	COG3156	type II secretion system protein K
AS145_20380	COG4795	General secretion pathway protein
AS145_20385	COG2165	general secretion pathway protein
AS145_20395	COG2165	general secretion pathway protein
AS145_20400	COG1459	type II secretion system
AS145_20405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS145_20415	COG3031	protein transport across the cell outer membrane
AS145_20425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AS145_20450	COG0456	acetyltransferase
AS145_20455	COG3133	Outer membrane lipoprotein
AS145_20470	COG2771	luxR family
AS145_20475	COG3916	Acyl-homoserine-lactone synthase
AS145_20485	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AS145_20490	COG1309	transcriptional regulator
AS145_20500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS145_20500	COG2213	PTS system mannitol-specific
AS145_20505	COG0246	Mannitol dehydrogenase
AS145_20510	COG3722	fumarate hydratase activity
AS145_20515	COG3263	regulation of cellular component size
AS145_20540	COG1671	Belongs to the UPF0178 family
AS145_20555	COG1988	membrane-bound metal-dependent
AS145_20560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS145_20565	COG0513	Belongs to the DEAD box helicase family
AS145_20590	COG1575	Belongs to the MenA family. Type 1 subfamily
AS145_20595	COG1169	isochorismate synthase
AS145_20600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS145_20605	COG0596	Alpha beta hydrolase
AS145_20610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS145_20615	COG1441	menaquinone biosynthetic process
AS145_20620	COG0318	PFAM AMP-dependent synthetase and ligase
AS145_20635	COG3539	Fimbrial protein
AS145_20640	COG3121	Chaperone
AS145_20645	COG3188	usher protein
AS145_20655	COG3539	Fimbrial protein
AS145_20665	COG3291	Pkd domain containing protein
AS145_20670	COG2949	membrane
AS145_20685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AS145_20690	COG5380	lipid catabolic process
AS145_20705	COG4533	DNA binding
AS145_20710	COG2873	o-acetylhomoserine
AS145_20720	COG1979	alcohol dehydrogenase
AS145_20740	COG4221	oxidoreductase activity
AS145_20760	COG1285	pathogenesis
AS145_20780	COG1368	sulfuric ester hydrolase activity
AS145_20785	COG1522	sequence-specific DNA binding
AS145_20795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AS145_20800	COG1418	mRNA catabolic process
AS145_20805	COG1058	Belongs to the CinA family
AS145_20805	COG1546	Belongs to the CinA family
AS145_20820	COG1129	ABC transporter
AS145_20820	COG0842	Transport permease protein
AS145_20835	COG0561	phosphatase activity
AS145_20840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AS145_20860	COG1011	Hydrolase
AS145_20875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AS145_20880	COG0019	diaminopimelate decarboxylase activity
AS145_20885	COG1965	Belongs to the frataxin family
AS145_20890	COG0400	carboxylic ester hydrolase activity
AS145_20895	COG3072	Adenylate cyclase
AS145_20900	COG0181	hydroxymethylbilane synthase activity
AS145_20910	COG2959	enzyme of heme biosynthesis
AS145_20925	COG1494	fructose-1,6-bisphosphatase
AS145_20965	COG1733	regulation of RNA biosynthetic process
AS145_20985	COG3932	Exopolysaccharide synthesis, ExoD
AS145_20990	COG0814	amino acid
AS145_20995	COG3706	GGDEF domain
AS145_21010	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AS145_21020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AS145_21025	COG2022	thiamine diphosphate biosynthetic process
AS145_21035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS145_21040	COG0352	thiamine-phosphate diphosphorylase activity
AS145_21045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AS145_21065	COG0745	RESPONSE REGULATOR receiver
AS145_21075	COG1114	Component of the transport system for branched-chain amino acids
AS145_21080	COG0189	ligase activity
AS145_21115	COG3171	Protein conserved in bacteria
AS145_21130	COG3188	usher protein
AS145_21180	COG1639	'signal transduction protein
AS145_21190	COG2321	neutral zinc metallopeptidase
AS145_21195	COG3700	Belongs to the class B bacterial acid phosphatase family
AS145_21215	COG1366	Belongs to the anti-sigma-factor antagonist family
AS145_21220	COG2172	sigma factor antagonist activity
AS145_21225	COG5002	protein histidine kinase activity
AS145_21225	COG2205	protein histidine kinase activity
AS145_21225	COG0784	Response regulator, receiver
AS145_21230	COG3437	response regulator, receiver
AS145_21240	COG0477	Major facilitator Superfamily
AS145_21255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AS145_21260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS145_21260	COG1263	PTS System
AS145_21280	COG0312	modulator of DNA gyrase
AS145_21285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS145_21295	COG3164	Protein of unknown function
AS145_21300	COG1530	ribonuclease E activity
AS145_21305	COG0424	maF-like protein
AS145_21310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AS145_21315	COG1792	Involved in formation and maintenance of cell shape
AS145_21320	COG1077	Cell shape determining protein MreB Mrl
AS145_21345	COG4968	Prepilin-type N-terminal cleavage methylation domain
AS145_21365	COG1459	type II secretion system
AS145_21370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS145_21380	COG2842	Transposition protein
AS145_21415	COG2199	diguanylate cyclase activity
AS145_21415	COG2200	EAL domain
AS145_21420	COG2200	EAL domain
AS145_21425	COG0387	Pfam Sodium calcium exchanger
AS145_21430	COG2986	histidine ammonia-lyase
AS145_21435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AS145_21440	COG0010	Belongs to the arginase family
AS145_21445	COG1228	amidohydrolase
AS145_21450	COG2188	Transcriptional regulator
AS145_21455	COG0288	reversible hydration of carbon dioxide
AS145_21465	COG2177	Part of the ABC transporter FtsEX involved in
AS145_21470	COG2884	Cell division ATP-binding protein ftsE
AS145_21475	COG0552	protein localization to endoplasmic reticulum
AS145_21480	COG0742	ribosomal rna small subunit methyltransferase
AS145_21505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS145_21510	COG0741	lytic transglycosylase activity
AS145_21530	COG2095	MarC family integral membrane protein
AS145_21540	COG1301	dicarboxylic acid transport
AS145_21565	COG3714	YhhN family
AS145_21580	COG1770	oligopeptidase
AS145_21595	COG4221	oxidoreductase activity
AS145_21600	COG0583	DNA-binding transcription factor activity
AS145_21605	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS145_21650	COG0203	ribosomal protein L17
AS145_21655	COG0202	RNA polymerase activity
AS145_21660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AS145_21665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AS145_21670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AS145_21675	COG0201	protein transport
AS145_21680	COG0200	Binds to the 23S rRNA
AS145_21685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS145_21690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AS145_21695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AS145_21700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AS145_21705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS145_21710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AS145_21715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AS145_21720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS145_21725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AS145_21730	COG0255	Belongs to the universal ribosomal protein uL29 family
AS145_21735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AS145_21740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AS145_21745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS145_21750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS145_21755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AS145_21760	COG0089	rRNA binding
AS145_21765	COG0088	Forms part of the polypeptide exit tunnel
AS145_21770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS145_21775	COG0051	transcription antitermination factor activity, RNA binding
AS145_21790	COG0745	RESPONSE REGULATOR receiver
AS145_21795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS145_21800	COG2183	response to ionizing radiation
AS145_21820	COG0596	Alpha beta hydrolase
AS145_21825	COG1040	competence protein
AS145_21830	COG0316	Belongs to the HesB IscA family
AS145_21830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AS145_21835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AS145_21840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AS145_21845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS145_21850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AS145_21855	COG4942	peptidase
AS145_21865	COG1609	Transcriptional regulator
AS145_21870	COG0800	Aldolase
AS145_21875	COG0129	dihydroxy-acid dehydratase activity
AS145_21880	COG3265	gluconokinase activity
AS145_21885	COG2610	gluconate transmembrane transporter activity
AS145_21890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS145_21895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS145_21905	COG0456	acetyltransferase
AS145_21915	COG1490	D-aminoacyl-tRNA deacylase activity
AS145_21920	COG1295	ribonuclease BN
AS145_21930	COG0174	glutamine synthetase
AS145_21940	COG3852	Histidine kinase
AS145_21945	COG2204	response regulator
AS145_21950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS145_21955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS145_21965	COG3078	GTPase activator activity
AS145_21980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AS145_21990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS145_21995	COG0408	coproporphyrinogen oxidase activity
AS145_22000	COG0009	L-threonylcarbamoyladenylate synthase
AS145_22010	COG0551	DNA topoisomerase type I activity
AS145_22015	COG2922	Belongs to the Smg family
AS145_22020	COG0758	DNA mediated transformation
AS145_22030	COG0242	peptide deformylase activity
AS145_22035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS145_22040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS145_22040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS145_22045	COG0569	domain protein
AS145_22050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS145_22055	COG1322	Protein conserved in bacteria
AS145_22075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS145_22080	COG0686	Belongs to the AlaDH PNT family
AS145_22085	COG0519	Catalyzes the synthesis of GMP from XMP
AS145_22085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS145_22100	COG1396	sequence-specific DNA binding
AS145_22105	COG1012	belongs to the aldehyde dehydrogenase family
AS145_22115	COG2962	Rard protein
AS145_22125	COG1280	lysine exporter protein (LysE YggA)
AS145_22135	COG2391	methyltransferase activity
AS145_22140	COG1280	lysine exporter protein (LysE YggA)
AS145_22185	COG0583	DNA-binding transcription factor activity
AS145_22190	COG1943	Transposase
AS145_22195	COG0210	DNA helicase
AS145_22220	COG0583	DNA-binding transcription factor activity
AS145_22240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS145_22245	COG0385	Bile acid
AS145_22250	COG0531	amino acid
AS145_22255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS145_22260	COG0531	amino acid
AS145_22265	COG2731	YhcH YjgK YiaL family protein
AS145_22270	COG3250	beta-galactosidase activity
AS145_22275	COG1609	Transcriptional regulator
AS145_22310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS145_22315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS145_22315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS145_22320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AS145_22325	COG3074	FtsZ-dependent cytokinesis
AS145_22335	COG1045	serine acetyltransferase
AS145_22345	COG0745	RESPONSE REGULATOR receiver
AS145_22350	COG2205	protein histidine kinase activity
AS145_22355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS145_22360	COG0534	Mate efflux family protein
AS145_22375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS145_22380	COG2937	Belongs to the GPAT DAPAT family
AS145_22385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AS145_22390	COG3161	chorismate lyase activity
AS145_22395	COG1580	Controls the rotational direction of flagella during chemotaxis
AS145_22405	COG0604	alcohol dehydrogenase
AS145_22410	COG1609	Transcriptional regulator
AS145_22430	COG1519	Transferase
AS145_22435	COG0859	PFAM glycosyl transferase family 9
AS145_22440	COG0463	Glycosyl transferase, family 2
AS145_22445	COG0859	PFAM glycosyl transferase family 9
AS145_22450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS145_22455	COG2990	Protein conserved in bacteria
AS145_22460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS145_22470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS145_22475	COG2003	Belongs to the UPF0758 family
AS145_22480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS145_22485	COG0756	dUTP diphosphatase activity
AS145_22490	COG1309	transcriptional regulator
AS145_22495	COG0668	transmembrane transport
AS145_22505	COG0166	Belongs to the GPI family
AS145_22510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS145_22515	COG0583	DNA-binding transcription factor activity
AS145_22555	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AS145_22560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS145_22565	COG1739	Uncharacterized protein family UPF0029
AS145_22570	COG0006	proline dipeptidase activity
AS145_22575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS145_22580	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS145_22580	COG1024	Enoyl-CoA hydratase
AS145_22585	COG0183	Belongs to the thiolase family
AS145_22590	COG0745	RESPONSE REGULATOR receiver
AS145_22595	COG2205	protein histidine kinase activity
AS145_22610	COG0425	Belongs to the sulfur carrier protein TusA family
AS145_22615	COG0251	oxidation-reduction process
AS145_22620	COG2885	chlorophyll binding
AS145_22625	COG1335	isochorismatase
AS145_22630	COG2818	Glycosylase
AS145_22635	COG0752	glycyl-tRNA synthetase alpha subunit
AS145_22640	COG0751	glycine-tRNA ligase activity
AS145_22655	COG0529	Catalyzes the synthesis of activated sulfate
AS145_22655	COG2046	Belongs to the sulfate adenylyltransferase family
AS145_22675	COG0814	amino acid
AS145_22680	COG0348	domain, Protein
AS145_22690	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS145_22695	COG0426	domain, Protein
AS145_22695	COG1773	rubredoxin
AS145_22700	COG3604	Transcriptional regulator
AS145_22705	COG2188	Transcriptional regulator
AS145_22720	COG1609	Transcriptional regulator
AS145_22730	COG0559	Belongs to the binding-protein-dependent transport system permease family
AS145_22760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS145_22785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AS145_22795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AS145_22800	COG3118	belongs to the thioredoxin family
AS145_22805	COG0513	Belongs to the DEAD box helicase family
AS145_22810	COG0248	Ppx GppA phosphatase
AS145_22825	COG0742	ribosomal rna small subunit methyltransferase
AS145_22845	COG0084	hydrolase, TatD family'
AS145_22850	COG0805	protein transport
AS145_22855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS145_22865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS145_22870	COG3165	ubiquinone biosynthetic process from chorismate
AS145_22880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS145_22885	COG0402	S-adenosylhomocysteine deaminase activity
AS145_22925	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AS145_22930	COG0848	biopolymer transport protein
AS145_22935	COG0811	peptide transport
AS145_22940	COG0811	peptide transport
AS145_22950	COG2771	luxR family
AS145_22955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS145_22960	COG1349	DNA-binding transcription factor activity
AS145_22965	COG0745	RESPONSE REGULATOR receiver
AS145_22970	COG2205	protein histidine kinase activity
AS145_22980	COG4452	Inner membrane protein CreD
AS145_22985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS145_22990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AS145_22995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS145_23000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AS145_23005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS145_23010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS145_23015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AS145_23025	COG0356	it plays a direct role in the translocation of protons across the membrane
AS145_23035	COG1475	DNA binding
AS145_23040	COG1192	Involved in chromosome partitioning
AS145_23045	COG0357	Ribosomal RNA small subunit methyltransferase G
AS145_23050	COG0445	tRNA wobble uridine modification
AS145_23055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS145_23060	COG4774	siderophore transport
AS145_23065	COG4615	Cyclic peptide transporter
AS145_23070	COG1120	ATPase activity
AS145_23085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AS145_23090	COG0706	membrane insertase activity
AS145_23095	COG0594	ribonuclease P activity
AS145_23100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AS145_23170	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AS145_23225	COG1192	Involved in chromosome partitioning