locus-tag	class	description
C7K70_00010	COG0752	glycyl-tRNA synthetase alpha subunit
C7K70_00015	COG2818	Glycosylase
C7K70_00020	COG1335	isochorismatase
C7K70_00025	COG2885	chlorophyll binding
C7K70_00030	COG0251	oxidation-reduction process
C7K70_00035	COG0425	Belongs to the sulfur carrier protein TusA family
C7K70_00050	COG2205	protein histidine kinase activity
C7K70_00055	COG0745	RESPONSE REGULATOR receiver
C7K70_00060	COG0183	Belongs to the thiolase family
C7K70_00065	COG1024	Enoyl-CoA hydratase
C7K70_00065	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7K70_00070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7K70_00075	COG0006	proline dipeptidase activity
C7K70_00080	COG1739	Uncharacterized protein family UPF0029
C7K70_00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_00090	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C7K70_00120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C7K70_00125	COG2166	iron-sulfur cluster assembly
C7K70_00130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K70_00135	COG0210	DNA helicase
C7K70_00145	COG3245	cytochrome
C7K70_00150	COG1063	alcohol dehydrogenase
C7K70_00155	COG0156	8-amino-7-oxononanoate synthase activity
C7K70_00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_00180	COG3306	glycosyltransferase involved in LPS biosynthesis
C7K70_00200	COG1561	YicC-like family, N-terminal region
C7K70_00205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7K70_00210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7K70_00220	COG0789	Transcriptional regulator
C7K70_00225	COG3706	GGDEF domain
C7K70_00225	COG4251	negative regulation of phosphorylation
C7K70_00225	COG5001	Diguanylate cyclase
C7K70_00225	COG2203	Gaf domain
C7K70_00230	COG3084	Protein conserved in bacteria
C7K70_00240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7K70_00245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_00250	COG3639	organic phosphonate transmembrane transporter activity
C7K70_00255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C7K70_00260	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C7K70_00270	COG1335	isochorismatase
C7K70_00280	COG1683	Conserved Protein
C7K70_00285	COG0204	Acyl-transferase
C7K70_00290	COG0204	Acyl-transferase
C7K70_00295	COG0606	chelatase, subunit chli
C7K70_00310	COG3978	acetolactate synthase activity
C7K70_00315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K70_00320	COG0129	dihydroxy-acid dehydratase activity
C7K70_00340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7K70_00345	COG0254	rRNA binding
C7K70_00350	COG0702	epimerase
C7K70_00355	COG0281	malic enzyme
C7K70_00365	COG2205	protein histidine kinase activity
C7K70_00370	COG0745	RESPONSE REGULATOR receiver
C7K70_00375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_00410	COG4310	Domain of unknown function (DUF2172)
C7K70_00430	COG2089	acid synthase
C7K70_00440	COG1083	cytidylyl-transferase
C7K70_00455	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_00460	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_00475	COG1215	transferase activity, transferring glycosyl groups
C7K70_00500	COG1216	Glycosyl transferase, family 2
C7K70_00510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_00525	COG2089	acid synthase
C7K70_00530	COG1083	cytidylyl-transferase
C7K70_00550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7K70_00555	COG1086	Polysaccharide biosynthesis protein
C7K70_00560	COG0366	Alpha amylase catalytic
C7K70_00575	COG0443	Heat shock 70 kDa protein
C7K70_00580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K70_00585	COG3045	CreA protein
C7K70_00600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7K70_00605	COG0174	glutamine synthetase
C7K70_00625	COG3842	ATPase activity
C7K70_00630	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_00635	COG1177	transmembrane transport
C7K70_00640	COG2258	MOSC domain
C7K70_00660	COG2050	protein possibly involved in aromatic compounds catabolism
C7K70_00665	COG0514	ATP-dependent DNA helicase (RecQ)
C7K70_00675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C7K70_00685	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C7K70_00690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7K70_00700	COG2239	Acts as a magnesium transporter
C7K70_00705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7K70_00705	COG1648	precorrin-2 dehydrogenase activity
C7K70_00710	COG2116	formate transmembrane transporter activity
C7K70_00715	COG2146	nitrite reductase [NAD(P)H] activity
C7K70_00720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_00730	COG0477	Major facilitator Superfamily
C7K70_00735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7K70_00740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7K70_00760	COG1595	DNA-templated transcription, initiation
C7K70_00765	COG3806	Anti-sigma factor
C7K70_00770	COG1968	undecaprenyl-diphosphatase activity
C7K70_00775	COG0667	Aldo Keto reductase
C7K70_00780	COG2017	converts alpha-aldose to the beta-anomer
C7K70_00785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K70_00795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K70_00800	COG1609	Transcriptional regulator
C7K70_00805	COG3250	beta-galactosidase activity
C7K70_00825	COG0840	transmembrane signaling receptor activity
C7K70_00855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7K70_00860	COG1288	antiporter activity
C7K70_00865	COG1438	arginine binding
C7K70_00870	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C7K70_00875	COG0540	Belongs to the ATCase OTCase family
C7K70_00890	COG0688	phosphatidylethanolamine metabolic process
C7K70_00905	COG0583	DNA-binding transcription factor activity
C7K70_00915	COG3040	lipid binding
C7K70_00920	COG2207	Transcriptional regulator
C7K70_00925	COG1979	alcohol dehydrogenase
C7K70_00930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C7K70_00935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C7K70_00945	COG3681	Belongs to the UPF0597 family
C7K70_00955	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_00960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_00965	COG0564	pseudouridine synthase activity
C7K70_00975	COG0542	response to heat
C7K70_00980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7K70_00990	COG2502	aspartate--ammonia ligase
C7K70_00995	COG1522	sequence-specific DNA binding
C7K70_01005	COG5413	integral membrane protein
C7K70_01030	COG2205	protein histidine kinase activity
C7K70_01040	COG2204	response regulator
C7K70_01060	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C7K70_01075	COG0745	RESPONSE REGULATOR receiver
C7K70_01080	COG2205	protein histidine kinase activity
C7K70_01090	COG0243	molybdopterin cofactor binding
C7K70_01095	COG3005	denitrification pathway
C7K70_01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K70_01120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_01125	COG0569	domain protein
C7K70_01130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7K70_01155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K70_01165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K70_01170	COG0250	Participates in transcription elongation, termination and antitermination
C7K70_01175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7K70_01180	COG0081	regulation of translation
C7K70_01185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7K70_01190	COG0222	ribosome binding
C7K70_01195	COG0085	RNA polymerase activity
C7K70_01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7K70_01205	COG2964	Protein conserved in bacteria
C7K70_01210	COG0251	oxidation-reduction process
C7K70_01220	COG2923	Belongs to the DsrF TusC family
C7K70_01225	COG2168	tRNA wobble position uridine thiolation
C7K70_01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7K70_01235	COG0049	tRNA binding
C7K70_01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7K70_01245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K70_01250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7K70_01290	COG2252	PERMEase
C7K70_01295	COG2376	Dihydroxyacetone kinase
C7K70_01300	COG1461	Dihydroxyacetone kinase
C7K70_01315	COG3284	Transcriptional regulator
C7K70_01320	COG0583	DNA-binding transcription factor activity
C7K70_01325	COG2957	Belongs to the agmatine deiminase family
C7K70_01335	COG0628	permease
C7K70_01340	COG0494	nUDIX hydrolase
C7K70_01365	COG0753	catalase activity
C7K70_01370	COG1247	-acetyltransferase
C7K70_01390	COG3706	GGDEF domain
C7K70_01400	COG3842	ATPase activity
C7K70_01410	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_01435	COG0583	DNA-binding transcription factor activity
C7K70_01445	COG1741	Belongs to the pirin family
C7K70_01450	COG2259	Doxx family
C7K70_01455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C7K70_01460	COG1074	ATP-dependent DNA helicase activity
C7K70_01465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K70_01475	COG0346	lactoylglutathione lyase activity
C7K70_01515	COG0745	RESPONSE REGULATOR receiver
C7K70_01525	COG2203	Gaf domain
C7K70_01525	COG3706	GGDEF domain
C7K70_01525	COG4251	negative regulation of phosphorylation
C7K70_01525	COG5001	Diguanylate cyclase
C7K70_01530	COG4771	TonB-dependent receptor
C7K70_01540	COG1278	Cold shock
C7K70_01565	COG0629	single-stranded DNA binding
C7K70_01570	COG2197	response regulator
C7K70_01575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K70_01580	COG3706	GGDEF domain
C7K70_01585	COG3047	cAMP biosynthetic process
C7K70_01590	COG0840	transmembrane signaling receptor activity
C7K70_01615	COG3135	benzoate transporter
C7K70_01620	COG1396	sequence-specific DNA binding
C7K70_01650	COG2926	Belongs to the UPF0265 family
C7K70_01660	COG3028	Belongs to the UPF0307 family
C7K70_01665	COG0312	modulator of DNA gyrase
C7K70_01670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K70_01675	COG5007	Belongs to the BolA IbaG family
C7K70_01685	COG2854	intermembrane phospholipid transfer
C7K70_01690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C7K70_01695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7K70_01700	COG1127	ABC transporter
C7K70_01705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K70_01705	COG0517	IMP dehydrogenase activity
C7K70_01710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C7K70_01715	COG3117	lipopolysaccharide transmembrane transporter activity
C7K70_01720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C7K70_01725	COG1137	ATPase activity
C7K70_01730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7K70_01740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_01745	COG1660	Displays ATPase and GTPase activities
C7K70_01750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_01755	COG3711	transcriptional antiterminator
C7K70_01770	COG3964	amidohydrolase
C7K70_01800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K70_01805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K70_01815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C7K70_01820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7K70_01825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7K70_01830	COG0723	plastoquinol--plastocyanin reductase activity
C7K70_01835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7K70_01840	COG2857	Cytochrome c1
C7K70_01845	COG0625	glutathione transferase activity
C7K70_01850	COG2969	positive regulation of protein catabolic process
C7K70_01855	COG2823	Periplasmic or secreted lipoprotein
C7K70_01860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K70_01865	COG0792	nuclease activity
C7K70_01870	COG3107	peptidoglycan biosynthetic process
C7K70_01875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7K70_01920	COG2204	response regulator
C7K70_01925	COG1677	Flagellar hook-basal body complex protein FliE
C7K70_01935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C7K70_01970	COG1815	bacterial-type flagellum-dependent cell motility
C7K70_01975	COG1558	bacterial-type flagellum-dependent cell motility
C7K70_01980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C7K70_01985	COG1749	Flagellar hook protein flgE
C7K70_01995	COG4786	Flagellar basal body rod
C7K70_02000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C7K70_02005	COG1706	bacterial-type flagellum-dependent cell motility
C7K70_02015	COG1256	bacterial-type flagellum assembly
C7K70_02015	COG4786	Flagellar basal body rod
C7K70_02020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_02035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_02040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C7K70_02065	COG1191	sigma factor activity
C7K70_02070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_02075	COG1360	Flagellar Motor Protein
C7K70_02085	COG1388	LysM domain
C7K70_02085	COG0741	lytic transglycosylase activity
C7K70_02095	COG2001	Belongs to the MraZ family
C7K70_02100	COG0275	rRNA processing
C7K70_02105	COG3116	cell division
C7K70_02110	COG0768	penicillin binding
C7K70_02120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K70_02125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K70_02130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7K70_02135	COG0772	Belongs to the SEDS family
C7K70_02140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7K70_02145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K70_02150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7K70_02155	COG0849	cell division
C7K70_02160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C7K70_02165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C7K70_02175	COG0653	protein targeting
C7K70_02185	COG0494	nUDIX hydrolase
C7K70_02195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C7K70_02200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C7K70_02215	COG1459	type II secretion system
C7K70_02220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_02250	COG2186	Transcriptional regulator
C7K70_02255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C7K70_02260	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K70_02265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K70_02270	COG3447	MASE1 domain protein
C7K70_02270	COG5001	Diguanylate cyclase
C7K70_02270	COG5002	protein histidine kinase activity
C7K70_02280	COG0840	transmembrane signaling receptor activity
C7K70_02285	COG0840	transmembrane signaling receptor activity
C7K70_02290	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7K70_02295	COG1049	propionate catabolic process, 2-methylcitrate cycle
C7K70_02305	COG1280	lysine exporter protein (LysE YggA)
C7K70_02315	COG0523	cobalamin synthesis protein
C7K70_02320	COG0477	Major facilitator Superfamily
C7K70_02335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C7K70_02340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7K70_02430	COG0835	chemotaxis
C7K70_02430	COG0784	Response regulator, receiver
C7K70_02435	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_02440	COG1444	tRNA N-acetyltransferase activity
C7K70_02465	COG1803	Methylglyoxal synthase
C7K70_02480	COG0252	asparaginase activity
C7K70_02500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_02500	COG1263	PTS System
C7K70_02505	COG0366	Alpha amylase catalytic
C7K70_02510	COG0110	maltose O-acetyltransferase activity
C7K70_02515	COG1522	sequence-specific DNA binding
C7K70_02520	COG5006	permease, DMT superfamily
C7K70_02530	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_02535	COG1177	transmembrane transport
C7K70_02540	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_02545	COG3842	ATPase activity
C7K70_02550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C7K70_02555	COG0583	DNA-binding transcription factor activity
C7K70_02560	COG1757	Na H antiporter
C7K70_02600	COG0297	glycogen (starch) synthase activity
C7K70_02605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_02610	COG2813	Specifically methylates the guanine in position
C7K70_02615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7K70_02620	COG2203	Gaf domain
C7K70_02620	COG4251	negative regulation of phosphorylation
C7K70_02620	COG5001	Diguanylate cyclase
C7K70_02620	COG3706	GGDEF domain
C7K70_02630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_02640	COG2995	paraquat-inducible protein a
C7K70_02645	COG3008	intermembrane lipid transfer
C7K70_02645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C7K70_02650	COG3009	Protein conserved in bacteria
C7K70_02655	COG2885	chlorophyll binding
C7K70_02655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C7K70_02665	COG3240	lipase activity
C7K70_02670	COG3111	PFAM Bacterial OB fold (BOF) protein
C7K70_02680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C7K70_02685	COG1194	a g-specific adenine glycosylase
C7K70_02695	COG3267	Type II secretory pathway component ExeA
C7K70_02695	COG3409	Peptidoglycan-binding domain 1 protein
C7K70_02700	COG0617	tRNA 3'-terminal CCA addition
C7K70_02715	COG1346	cytolysis
C7K70_02720	COG1380	Effector of murein hydrolase LrgA
C7K70_02725	COG0583	DNA-binding transcription factor activity
C7K70_02755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K70_02760	COG0306	phosphate transporter
C7K70_02765	COG1392	Phosphate transport regulator
C7K70_02780	COG1560	Kdo2-lipid A biosynthetic process
C7K70_02785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C7K70_02785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7K70_02790	COG1538	Outer membrane efflux protein
C7K70_02795	COG0494	nUDIX hydrolase
C7K70_02800	COG3151	Protein conserved in bacteria
C7K70_02810	COG3150	esterase
C7K70_02815	COG1051	belongs to the nudix hydrolase family
C7K70_02830	COG1566	PFAM secretion protein HlyD family protein
C7K70_02835	COG1289	transmembrane transporter activity
C7K70_02840	COG0187	DNA topoisomerase II activity
C7K70_02905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_02930	COG0204	Acyl-transferase
C7K70_02935	COG1842	Phage shock protein A
C7K70_02950	COG2827	Endonuclease containing a URI domain
C7K70_02965	COG1573	uracil-dna glycosylase
C7K70_02970	COG0697	spore germination
C7K70_02975	COG0583	DNA-binding transcription factor activity
C7K70_02980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K70_02985	COG1121	(ABC) transporter
C7K70_02990	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C7K70_03010	COG0739	heme binding
C7K70_03020	COG3068	Protein conserved in bacteria
C7K70_03040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7K70_03045	COG1546	Belongs to the CinA family
C7K70_03050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7K70_03060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7K70_03065	COG0527	aspartate kinase activity
C7K70_03070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C7K70_03105	COG1686	Belongs to the peptidase S11 family
C7K70_03110	COG0586	Pfam SNARE associated Golgi protein
C7K70_03115	COG1253	flavin adenine dinucleotide binding
C7K70_03120	COG0525	valine-tRNA ligase activity
C7K70_03125	COG2927	DNA polymerase III (CHI subunit)
C7K70_03130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_03135	COG0795	lipopolysaccharide-transporting ATPase activity
C7K70_03140	COG0795	lipopolysaccharide-transporting ATPase activity
C7K70_03155	COG0582	viral genome integration into host DNA
C7K70_03210	COG0004	ammonium transporteR
C7K70_03215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_03230	COG0084	hydrolase, TatD family'
C7K70_03235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_03245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K70_03250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7K70_03255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7K70_03260	COG0813	purine-nucleoside phosphorylase activity
C7K70_03265	COG3447	MASE1 domain protein
C7K70_03265	COG5001	Diguanylate cyclase
C7K70_03265	COG5002	protein histidine kinase activity
C7K70_03275	COG0560	Phosphoserine phosphatase
C7K70_03300	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C7K70_03305	COG0776	regulation of translation
C7K70_03320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K70_03325	COG0735	belongs to the Fur family
C7K70_03350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7K70_03355	COG0513	Belongs to the DEAD box helicase family
C7K70_03360	COG3022	response to hydroperoxide
C7K70_03375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7K70_03380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7K70_03385	COG0762	integral membrane protein
C7K70_03390	COG1872	DUF167
C7K70_03405	COG4166	transmembrane transport
C7K70_03425	COG1024	Enoyl-CoA hydratase
C7K70_03440	COG4221	oxidoreductase activity
C7K70_03445	COG0442	prolyl-tRNA aminoacylation
C7K70_03450	COG0840	transmembrane signaling receptor activity
C7K70_03455	COG0632	four-way junction helicase activity
C7K70_03460	COG2255	four-way junction helicase activity
C7K70_03465	COG1271	oxidase subunit
C7K70_03470	COG1294	oxidase, subunit
C7K70_03475	COG4890	Cyd operon protein YbgT
C7K70_03480	COG3790	cyd operon protein YbgE
C7K70_03485	COG0824	Thioesterase
C7K70_03490	COG0811	peptide transport
C7K70_03505	COG0823	Involved in the tonB-independent uptake of proteins
C7K70_03510	COG2885	chlorophyll binding
C7K70_03515	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C7K70_03590	COG0840	transmembrane signaling receptor activity
C7K70_03595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C7K70_03600	COG0676	glucose-6-phosphate 1-epimerase activity
C7K70_03605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7K70_03610	COG1640	4-alpha-glucanotransferase
C7K70_03615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7K70_03635	COG1051	belongs to the nudix hydrolase family
C7K70_03640	COG2130	NADP-dependent
C7K70_03645	COG1764	response to oxidative stress
C7K70_03650	COG1846	Transcriptional regulator
C7K70_03665	COG1522	sequence-specific DNA binding
C7K70_03680	COG0561	phosphatase activity
C7K70_03695	COG0733	neurotransmitter:sodium symporter activity
C7K70_03705	COG0733	neurotransmitter:sodium symporter activity
C7K70_03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_03740	COG1794	racemase activity, acting on amino acids and derivatives
C7K70_03755	COG2731	YhcH YjgK YiaL family protein
C7K70_03765	COG0668	transmembrane transport
C7K70_03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7K70_03815	COG0583	DNA-binding transcription factor activity
C7K70_03820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C7K70_03830	COG0488	(ABC) transporter
C7K70_03835	COG0517	IMP dehydrogenase activity
C7K70_03835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K70_03840	COG1585	Membrane protein implicated in regulation of membrane protease activity
C7K70_03845	COG0330	HflC and HflK could
C7K70_03850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7K70_03850	COG1648	precorrin-2 dehydrogenase activity
C7K70_03855	COG0175	sulfate reduction
C7K70_03860	COG2895	sulfate adenylyltransferase (ATP) activity
C7K70_03865	COG3273	potassium ion transport
C7K70_03865	COG0471	metal ion transport
C7K70_03870	COG0529	Catalyzes the synthesis of activated sulfate
C7K70_03900	COG0625	glutathione transferase activity
C7K70_03940	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C7K70_03960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7K70_03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K70_03970	COG0163	prenyltransferase activity
C7K70_03985	COG1131	(ABC) transporter
C7K70_03990	COG0842	Transport permease protein
C7K70_03995	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C7K70_04000	COG1924	4 iron, 4 sulfur cluster binding
C7K70_04020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7K70_04025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7K70_04040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_04045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7K70_04050	COG1489	DNA binding
C7K70_04060	COG1643	Atp-dependent helicase
C7K70_04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K70_04070	COG0346	lactoylglutathione lyase activity
C7K70_04080	COG2076	Multidrug Resistance protein
C7K70_04090	COG3437	response regulator, receiver
C7K70_04090	COG0784	Response regulator, receiver
C7K70_04100	COG0671	phosphoesterase, PA-phosphatase related
C7K70_04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7K70_04120	COG0038	chloride channel
C7K70_04130	COG0316	Belongs to the HesB IscA family
C7K70_04160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_04170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C7K70_04175	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C7K70_04180	COG1178	ABC-type Fe3 transport system permease component
C7K70_04185	COG4143	(ABC) transporter
C7K70_04200	COG0066	3-isopropylmalate dehydratase activity
C7K70_04205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7K70_04210	COG0473	3-isopropylmalate dehydrogenase activity
C7K70_04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7K70_04225	COG0671	phosphoesterase, PA-phosphatase related
C7K70_04230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7K70_04240	COG0028	Belongs to the TPP enzyme family
C7K70_04255	COG0857	belongs to the CobB CobQ family
C7K70_04255	COG0280	phosphate acetyltransferase
C7K70_04260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7K70_04265	COG3092	negative regulation of chromosome organization
C7K70_04270	COG3013	Belongs to the UPF0304 family
C7K70_04275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7K70_04280	COG2716	regulation of RNA biosynthetic process
C7K70_04290	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C7K70_04295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7K70_04310	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C7K70_04330	COG0784	Response regulator, receiver
C7K70_04330	COG2198	Histidine kinase
C7K70_04330	COG5002	protein histidine kinase activity
C7K70_04355	COG0840	transmembrane signaling receptor activity
C7K70_04365	COG1464	Belongs to the NlpA lipoprotein family
C7K70_04370	COG2011	ABC-type metal ion transport system permease component
C7K70_04375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K70_04400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7K70_04400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7K70_04405	COG0802	atpase or kinase
C7K70_04415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7K70_04420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7K70_04425	COG1923	regulation of RNA biosynthetic process
C7K70_04430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7K70_04435	COG0330	HflC and HflK could
C7K70_04440	COG0330	HflC and HflK could
C7K70_04445	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C7K70_04450	COG0142	geranyltranstransferase activity
C7K70_04455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7K70_04460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7K70_04465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7K70_04475	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_04490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_04495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7K70_04505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7K70_04515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7K70_04520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7K70_04530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C7K70_04535	COG3178	'Phosphotransferase
C7K70_04540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7K70_04545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7K70_04550	COG2252	PERMEase
C7K70_04560	COG0488	(ABC) transporter
C7K70_04575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K70_04580	COG0741	lytic transglycosylase activity
C7K70_04600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7K70_04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_04610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K70_04635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_04645	COG3721	Heme iron utilization protein
C7K70_04650	COG0748	coenzyme F420 binding
C7K70_04670	COG4771	TonB-dependent receptor
C7K70_04680	COG2814	Major facilitator Superfamily
C7K70_04685	COG3655	Transcriptional regulator
C7K70_04695	COG2202	Pas domain
C7K70_04695	COG2205	protein histidine kinase activity
C7K70_04710	COG3397	chitin binding
C7K70_04715	COG2226	methyltransferase
C7K70_04720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K70_04725	COG1765	OsmC-like protein
C7K70_04740	COG3954	Phosphoribulokinase
C7K70_04745	COG2076	Multidrug Resistance protein
C7K70_04750	COG2076	Multidrug Resistance protein
C7K70_04755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7K70_04760	COG0726	polysaccharide deacetylase
C7K70_04765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_04765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K70_04770	COG0463	Glycosyl transferase, family 2
C7K70_04775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7K70_04785	COG3089	Belongs to the UPF0270 family
C7K70_04790	COG4251	negative regulation of phosphorylation
C7K70_04790	COG3706	GGDEF domain
C7K70_04790	COG2203	Gaf domain
C7K70_04790	COG5001	Diguanylate cyclase
C7K70_04795	COG0429	hydrolase of the alpha beta-hydrolase fold
C7K70_04800	COG0784	Response regulator, receiver
C7K70_04800	COG0835	chemotaxis
C7K70_04810	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C7K70_04815	COG1047	Peptidyl-prolyl cis-trans
C7K70_04820	COG2900	Belongs to the SlyX family
C7K70_04830	COG0545	Peptidyl-prolyl cis-trans isomerase
C7K70_04835	COG2204	response regulator
C7K70_04855	COG0737	Belongs to the 5'-nucleotidase family
C7K70_04860	COG2200	EAL domain
C7K70_04875	COG0305	Participates in initiation and elongation during chromosome replication
C7K70_04880	COG0305	Participates in initiation and elongation during chromosome replication
C7K70_04885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_04895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_04905	COG2199	diguanylate cyclase activity
C7K70_04905	COG2203	Gaf domain
C7K70_04905	COG2200	EAL domain
C7K70_04935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K70_04940	COG2201	protein-glutamate methylesterase activity
C7K70_04945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C7K70_04955	COG0840	transmembrane signaling receptor activity
C7K70_04960	COG0835	chemotaxis
C7K70_04970	COG0643	Histidine kinase
C7K70_04970	COG2198	Histidine kinase
C7K70_04980	COG0745	RESPONSE REGULATOR receiver
C7K70_04985	COG0840	transmembrane signaling receptor activity
C7K70_05000	COG1280	lysine exporter protein (LysE YggA)
C7K70_05005	COG0826	peptidase U32
C7K70_05035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7K70_05060	COG0300	oxidoreductase activity
C7K70_05070	COG0840	transmembrane signaling receptor activity
C7K70_05080	COG2610	gluconate transmembrane transporter activity
C7K70_05085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_05090	COG3622	Belongs to the hyi family
C7K70_05095	COG0235	Class ii aldolase
C7K70_05105	COG2084	Dehydrogenase
C7K70_05110	COG1349	DNA-binding transcription factor activity
C7K70_05135	COG0077	Prephenate dehydratase
C7K70_05135	COG1605	Chorismate mutase
C7K70_05165	COG3272	Protein of unknown function (DUF1722)
C7K70_05170	COG0789	Transcriptional regulator
C7K70_05175	COG0415	Belongs to the DNA photolyase family
C7K70_05185	COG4221	oxidoreductase activity
C7K70_05200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7K70_05225	COG0783	Belongs to the Dps family
C7K70_05230	COG1151	hydroxylamine reductase activity
C7K70_05240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K70_05245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_05245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_05335	COG2003	Belongs to the UPF0758 family
C7K70_05385	COG4983	Phage plasmid primase, P4 family domain protein
C7K70_05395	COG2916	Histone family protein nucleoid-structuring protein H-NS
C7K70_05415	COG3501	Rhs element vgr protein
C7K70_05475	COG0582	viral genome integration into host DNA
C7K70_05505	COG0693	protein deglycase activity
C7K70_05510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7K70_05515	COG1666	GTP binding
C7K70_05520	COG3248	Nucleoside-binding outer membrane protein
C7K70_05525	COG2211	Major facilitator Superfamily
C7K70_05535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K70_05545	COG2813	Specifically methylates the guanine in position
C7K70_05550	COG0271	Belongs to the BolA IbaG family
C7K70_05555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_05560	COG1805	sodium ion transport
C7K70_05565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_05570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_05575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_05580	COG2871	sodium ion transport
C7K70_05585	COG1477	protein flavinylation
C7K70_05600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7K70_05605	COG0840	transmembrane signaling receptor activity
C7K70_05610	COG0583	DNA-binding transcription factor activity
C7K70_05620	COG2363	Small membrane protein
C7K70_05625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C7K70_05635	COG0473	3-isopropylmalate dehydrogenase activity
C7K70_05640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_05645	COG1611	Belongs to the LOG family
C7K70_05650	COG3706	GGDEF domain
C7K70_05660	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7K70_05660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7K70_05670	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C7K70_05695	COG3098	single-species biofilm formation
C7K70_05700	COG0564	pseudouridine synthase activity
C7K70_05710	COG4580	involved in the transport of maltose and maltodextrins
C7K70_05720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_05720	COG1263	PTS System
C7K70_05730	COG2171	N-acyltransferase activity
C7K70_05735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C7K70_05740	COG0024	Methionine aminopeptidase
C7K70_05745	COG0052	Belongs to the universal ribosomal protein uS2 family
C7K70_05750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7K70_05755	COG0528	UMP kinase activity
C7K70_05760	COG0233	cytoplasmic translational termination
C7K70_05770	COG0575	Belongs to the CDS family
C7K70_05775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C7K70_05780	COG0750	zinc metalloprotease
C7K70_05795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_05800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K70_05805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_05810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_05815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K70_05825	COG0825	malonyl-CoA metabolic process
C7K70_05830	COG3710	Transcriptional regulator
C7K70_05840	COG0531	amino acid
C7K70_05845	COG1982	Orn Lys Arg decarboxylase major
C7K70_05850	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C7K70_05865	COG0814	amino acid
C7K70_05880	COG0531	amino acid
C7K70_05900	COG3590	peptidase
C7K70_05910	COG3706	GGDEF domain
C7K70_05945	COG0366	Alpha amylase catalytic
C7K70_05960	COG0463	Glycosyl transferase, family 2
C7K70_05975	COG2989	Protein conserved in bacteria
C7K70_05980	COG3108	Peptidase M15
C7K70_05990	COG2860	membrane
C7K70_06000	COG1196	nuclear chromosome segregation
C7K70_06005	COG3115	cell septum assembly
C7K70_06010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7K70_06020	COG1328	CTP reductase activity
C7K70_06025	COG0602	queuosine metabolic process
C7K70_06055	COG1566	PFAM secretion protein HlyD family protein
C7K70_06060	COG1846	Transcriptional regulator
C7K70_06075	COG0281	malic enzyme
C7K70_06080	COG3290	protein histidine kinase activity
C7K70_06085	COG4565	transcriptional regulatory protein
C7K70_06090	COG0697	spore germination
C7K70_06100	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_06105	COG3284	Transcriptional regulator
C7K70_06110	COG1960	acyl-CoA dehydrogenase activity
C7K70_06115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7K70_06120	COG0346	lactoylglutathione lyase activity
C7K70_06125	COG0745	RESPONSE REGULATOR receiver
C7K70_06130	COG5002	protein histidine kinase activity
C7K70_06140	COG4783	chaperone-mediated protein folding
C7K70_06155	COG3142	Participates in the control of copper homeostasis
C7K70_06170	COG0545	Peptidyl-prolyl cis-trans isomerase
C7K70_06175	COG1131	(ABC) transporter
C7K70_06195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C7K70_06205	COG0678	peroxiredoxin activity
C7K70_06215	COG0019	diaminopimelate decarboxylase activity
C7K70_06220	COG1115	amino acid carrier protein
C7K70_06225	COG0095	Lipoate-protein ligase
C7K70_06230	COG2233	PERMEase
C7K70_06235	COG3706	GGDEF domain
C7K70_06235	COG0745	RESPONSE REGULATOR receiver
C7K70_06245	COG0534	Mate efflux family protein
C7K70_06255	COG0281	malic enzyme
C7K70_06285	COG0733	neurotransmitter:sodium symporter activity
C7K70_06290	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7K70_06295	COG2203	Gaf domain
C7K70_06295	COG2199	diguanylate cyclase activity
C7K70_06300	COG1566	PFAM secretion protein HlyD family protein
C7K70_06305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_06315	COG1032	radical SAM domain protein
C7K70_06355	COG0673	inositol 2-dehydrogenase activity
C7K70_06365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C7K70_06370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K70_06380	COG0741	lytic transglycosylase activity
C7K70_06380	COG0739	heme binding
C7K70_06380	COG1196	nuclear chromosome segregation
C7K70_06385	COG0366	Alpha amylase catalytic
C7K70_06405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_06415	COG0788	formyltetrahydrofolate deformylase activity
C7K70_06420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7K70_06430	COG3118	belongs to the thioredoxin family
C7K70_06435	COG2091	lysine biosynthetic process via aminoadipic acid
C7K70_06440	COG0791	NLP P60 protein
C7K70_06445	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C7K70_06460	COG1388	LysM domain
C7K70_06460	COG1376	ErfK ybiS ycfS ynhG family protein
C7K70_06475	COG3318	Belongs to the UPF0149 family
C7K70_06475	COG3012	SEC-C Motif Domain Protein
C7K70_06490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C7K70_06540	COG2003	Belongs to the UPF0758 family
C7K70_06630	COG3311	Transcriptional regulator
C7K70_06640	COG0582	viral genome integration into host DNA
C7K70_06660	COG4869	propanediol catabolic process
C7K70_06665	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C7K70_06670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_06675	COG1882	Formate acetyltransferase
C7K70_06680	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_06680	COG1454	alcohol dehydrogenase
C7K70_06690	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_06690	COG1454	alcohol dehydrogenase
C7K70_06695	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C7K70_06700	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C7K70_06705	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C7K70_06725	COG0583	DNA-binding transcription factor activity
C7K70_06730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7K70_06735	COG0243	molybdopterin cofactor binding
C7K70_06745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7K70_06755	COG1960	acyl-CoA dehydrogenase activity
C7K70_06760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_06770	COG0469	pyruvate kinase activity
C7K70_06775	COG1737	Transcriptional regulator
C7K70_06790	COG0745	RESPONSE REGULATOR receiver
C7K70_06795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7K70_06810	COG1677	Flagellar hook-basal body complex protein FliE
C7K70_06820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C7K70_06870	COG1987	bacterial-type flagellum assembly
C7K70_06875	COG1684	flagellar biosynthetic protein fliR
C7K70_06885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C7K70_06895	COG0455	bacterial-type flagellum organization
C7K70_06910	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C7K70_06915	COG0643	Histidine kinase
C7K70_06915	COG2198	Histidine kinase
C7K70_06920	COG2201	protein-glutamate methylesterase activity
C7K70_06925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_06930	COG1360	Flagellar Motor Protein
C7K70_06935	COG1192	Involved in chromosome partitioning
C7K70_06945	COG0835	chemotaxis
C7K70_06960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_06965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_06970	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_06975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C7K70_06980	COG1138	Cytochrome C-type biogenesis protein
C7K70_06985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_06990	COG4235	cytochrome complex assembly
C7K70_06990	COG3088	subunit of a heme lyase
C7K70_06995	COG4235	cytochrome complex assembly
C7K70_06995	COG3088	subunit of a heme lyase
C7K70_07010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7K70_07015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_07015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_07030	COG0259	pyridoxamine-phosphate oxidase activity
C7K70_07035	COG0625	glutathione transferase activity
C7K70_07045	COG3153	acetyltransferase
C7K70_07050	COG2850	peptidyl-arginine hydroxylation
C7K70_07055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K70_07060	COG2915	High frequency lysogenization protein hflD homolog
C7K70_07065	COG0482	sulfurtransferase activity
C7K70_07075	COG1187	pseudouridine synthase activity
C7K70_07085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_07105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_07105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_07105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_07120	COG0456	acetyltransferase
C7K70_07130	COG1609	Transcriptional regulator
C7K70_07135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_07135	COG1263	PTS System
C7K70_07140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K70_07155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_07175	COG2207	Transcriptional regulator
C7K70_07180	COG0538	isocitrate dehydrogenase activity
C7K70_07190	COG3048	D-serine ammonia-lyase activity
C7K70_07195	COG0583	DNA-binding transcription factor activity
C7K70_07215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7K70_07220	COG2867	negative regulation of translational initiation
C7K70_07230	COG0702	epimerase
C7K70_07235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_07240	COG1454	alcohol dehydrogenase
C7K70_07250	COG0564	pseudouridine synthase activity
C7K70_07280	COG1280	lysine exporter protein (LysE YggA)
C7K70_07290	COG3263	regulation of cellular component size
C7K70_07300	COG3263	regulation of cellular component size
C7K70_07310	COG1876	peptidase activity
C7K70_07315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K70_07320	COG1393	Belongs to the ArsC family
C7K70_07325	COG0583	DNA-binding transcription factor activity
C7K70_07335	COG3069	C4-dicarboxylate transmembrane transporter activity
C7K70_07350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C7K70_07355	COG0017	Asparaginyl-tRNA synthetase
C7K70_07375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7K70_07380	COG0156	8-amino-7-oxononanoate synthase activity
C7K70_07385	COG1073	alpha beta
C7K70_07385	COG2226	methyltransferase
C7K70_07390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7K70_07395	COG0501	Belongs to the peptidase M48B family
C7K70_07405	COG3217	Mosc domain protein beta barrel domain protein
C7K70_07405	COG0633	Ferredoxin
C7K70_07405	COG3217	Mosc domain protein beta barrel domain protein
C7K70_07405	COG0633	Ferredoxin
C7K70_07415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7K70_07415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7K70_07415	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7K70_07415	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7K70_07420	COG2366	antibiotic biosynthetic process
C7K70_07440	COG0534	Mate efflux family protein
C7K70_07480	COG1309	transcriptional regulator
C7K70_07495	COG0791	NLP P60 protein
C7K70_07505	COG0583	DNA-binding transcription factor activity
C7K70_07510	COG0450	alkyl hydroperoxide reductase
C7K70_07530	COG0500	methyltransferase
C7K70_07535	COG4106	trans-aconitate 2-methyltransferase activity
C7K70_07540	COG1801	Protein of unknown function DUF72
C7K70_07545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7K70_07550	COG0217	transcriptional regulatory protein
C7K70_07555	COG2194	sulfuric ester hydrolase activity
C7K70_07560	COG1940	carbohydrate kinase activity
C7K70_07560	COG1846	Transcriptional regulator
C7K70_07565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K70_07570	COG0363	glucosamine-6-phosphate deaminase activity
C7K70_07575	COG2190	(PTS) system
C7K70_07575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_07575	COG1263	PTS System
C7K70_07585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_07590	COG0735	belongs to the Fur family
C7K70_07600	COG0716	FMN binding
C7K70_07615	COG0596	Alpha beta hydrolase
C7K70_07620	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C7K70_07625	COG0033	Phosphoglucomutase
C7K70_07635	COG1846	Transcriptional regulator
C7K70_07650	COG2951	lytic endotransglycosylase activity
C7K70_07655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7K70_07660	COG4136	ATPase activity
C7K70_07670	COG4134	Bacterial extracellular solute-binding protein
C7K70_07680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K70_07690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K70_07695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K70_07705	COG0729	surface antigen
C7K70_07710	COG2911	Protein conserved in bacteria
C7K70_07730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7K70_07740	COG0741	lytic transglycosylase activity
C7K70_07755	COG1607	acyl-coa hydrolase
C7K70_07765	COG3021	interspecies interaction between organisms
C7K70_07770	COG0741	lytic transglycosylase activity
C7K70_07770	COG1388	LysM domain
C7K70_07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7K70_07780	COG2226	methyltransferase
C7K70_07785	COG0328	RNA-DNA hybrid ribonuclease activity
C7K70_07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7K70_07800	COG0784	Response regulator, receiver
C7K70_07800	COG3437	response regulator, receiver
C7K70_07805	COG1960	acyl-CoA dehydrogenase activity
C7K70_07810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K70_07815	COG0121	glutamine amidotransferase
C7K70_07835	COG0784	Response regulator, receiver
C7K70_07835	COG2205	protein histidine kinase activity
C7K70_07845	COG2197	response regulator
C7K70_07850	COG3850	Histidine kinase
C7K70_07855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7K70_07860	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_07860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_07870	COG0243	molybdopterin cofactor binding
C7K70_07875	COG0437	4 iron, 4 sulfur cluster binding
C7K70_07880	COG0348	domain, Protein
C7K70_07890	COG3005	denitrification pathway
C7K70_07895	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7K70_07900	COG0315	cyclic pyranopterin monophosphate synthase activity
C7K70_07905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C7K70_07910	COG0314	molybdopterin synthase activity
C7K70_07925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C7K70_07930	COG2267	carboxylic ester hydrolase activity
C7K70_07955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7K70_07965	COG0302	gtp cyclohydrolase
C7K70_07970	COG0840	transmembrane signaling receptor activity
C7K70_07975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K70_07980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K70_07990	COG0583	DNA-binding transcription factor activity
C7K70_08020	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K70_08040	COG1166	arginine decarboxylase activity
C7K70_08060	COG0814	amino acid
C7K70_08070	COG3681	Belongs to the UPF0597 family
C7K70_08075	COG2964	Protein conserved in bacteria
C7K70_08085	COG1061	Type III restriction enzyme res subunit
C7K70_08095	COG0346	lactoylglutathione lyase activity
C7K70_08115	COG1187	pseudouridine synthase activity
C7K70_08120	COG2807	transmembrane transport
C7K70_08130	COG0583	DNA-binding transcription factor activity
C7K70_08135	COG2271	Major facilitator Superfamily
C7K70_08165	COG2979	Protein of unknown function (DUF533)
C7K70_08175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_08180	COG1271	oxidase subunit
C7K70_08185	COG1294	oxidase, subunit
C7K70_08195	COG2814	Major facilitator Superfamily
C7K70_08200	COG0656	L-ascorbic acid biosynthetic process
C7K70_08220	COG0583	DNA-binding transcription factor activity
C7K70_08225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7K70_08230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K70_08235	COG2271	Major facilitator Superfamily
C7K70_08240	COG1349	DNA-binding transcription factor activity
C7K70_08250	COG0584	glycerophosphoryl diester phosphodiesterase
C7K70_08255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_08260	COG1605	Chorismate mutase
C7K70_08260	COG0287	Prephenate dehydrogenase
C7K70_08265	COG0583	DNA-binding transcription factor activity
C7K70_08270	COG3085	chromosome segregation
C7K70_08275	COG4574	serine-type endopeptidase inhibitor activity
C7K70_08295	COG1770	oligopeptidase
C7K70_08300	COG4771	TonB-dependent receptor
C7K70_08305	COG3083	sulfuric ester hydrolase activity
C7K70_08310	COG3082	Protein of unknown function (DUF1414)
C7K70_08315	COG3081	Nucleoid-associated protein
C7K70_08325	COG1175	transmembrane transport
C7K70_08335	COG3842	ATPase activity
C7K70_08355	COG0425	Belongs to the sulfur carrier protein TusA family
C7K70_08360	COG4783	chaperone-mediated protein folding
C7K70_08370	COG1393	Belongs to the ArsC family
C7K70_08385	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C7K70_08390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K70_08395	COG2431	L-lysine efflux transmembrane transporter activity
C7K70_08405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_08410	COG4215	(ABC) transporter
C7K70_08425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_08435	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_08450	COG1566	PFAM secretion protein HlyD family protein
C7K70_08455	COG1538	Outer membrane efflux protein
C7K70_08460	COG0628	permease
C7K70_08465	COG1473	amidohydrolase
C7K70_08470	COG2373	Large extracellular alpha-helical protein
C7K70_08475	COG4953	penicillin-binding protein 1C
C7K70_08485	COG0301	tRNA thio-modification
C7K70_08485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_08505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_08510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_08550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K70_08570	COG0483	inositol monophosphate 1-phosphatase activity
C7K70_08580	COG0625	glutathione transferase activity
C7K70_08585	COG2814	Major facilitator Superfamily
C7K70_08605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_08610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_08615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7K70_08620	COG0509	glycine decarboxylation via glycine cleavage system
C7K70_08625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7K70_08625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7K70_08630	COG0640	Transcriptional regulator
C7K70_08635	COG0798	PFAM Bile acid sodium symporter
C7K70_08640	COG1393	Belongs to the ArsC family
C7K70_08655	COG0477	Major facilitator Superfamily
C7K70_08660	COG3634	alkyl hydroperoxide reductase activity
C7K70_08665	COG0450	alkyl hydroperoxide reductase
C7K70_08670	COG0517	IMP dehydrogenase activity
C7K70_08675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7K70_08680	COG0343	queuine tRNA-ribosyltransferase activity
C7K70_08685	COG1862	Preprotein translocase
C7K70_08690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_08695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_08730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C7K70_08740	COG1104	cysteine desulfurase activity
C7K70_08745	COG0822	iron-sulfur transferase activity
C7K70_08755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7K70_08760	COG0443	Heat shock 70 kDa protein
C7K70_08765	COG0633	Ferredoxin
C7K70_08775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_08780	COG0105	UTP biosynthetic process
C7K70_08785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7K70_08800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C7K70_08805	COG0124	histidyl-tRNA synthetase
C7K70_08810	COG2976	Protein conserved in bacteria
C7K70_08815	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_08820	COG1160	GTP binding
C7K70_08825	COG1645	bacterial-type flagellum-dependent swarming motility
C7K70_08835	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C7K70_08840	COG0047	phosphoribosylformylglycinamidine synthase activity
C7K70_08840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7K70_08845	COG2199	diguanylate cyclase activity
C7K70_08845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_08860	COG1007	ATP synthesis coupled electron transport
C7K70_08865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_08875	COG0713	ATP synthesis coupled electron transport
C7K70_08880	COG0839	Belongs to the complex I subunit 6 family
C7K70_08885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_08890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7K70_08895	COG1034	ATP synthesis coupled electron transport
C7K70_08910	COG0649	NAD binding
C7K70_08910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_08915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_08920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_08925	COG1360	Flagellar Motor Protein
C7K70_08930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_08945	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C7K70_08965	COG0724	RNA recognition motif
C7K70_08970	COG4989	oxidoreductase activity
C7K70_08995	COG3437	response regulator, receiver
C7K70_09000	COG0583	DNA-binding transcription factor activity
C7K70_09010	COG3300	MHYT domain
C7K70_09010	COG5001	Diguanylate cyclase
C7K70_09015	COG0778	Nitroreductase
C7K70_09045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7K70_09050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7K70_09055	COG0539	negative regulation of cytoplasmic translation
C7K70_09060	COG0776	regulation of translation
C7K70_09070	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C7K70_09090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C7K70_09095	COG0602	queuosine metabolic process
C7K70_09100	COG3530	Putative quorum-sensing-regulated virulence factor
C7K70_09105	COG2096	Adenosyltransferase
C7K70_09110	COG2916	Histone family protein nucleoid-structuring protein H-NS
C7K70_09115	COG1757	Na H antiporter
C7K70_09120	COG1435	thymidine kinase activity
C7K70_09275	COG1301	dicarboxylic acid transport
C7K70_09295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K70_09310	COG0537	adenosine 5'-monophosphoramidase activity
C7K70_09345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_09350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_09360	COG2354	Protein conserved in bacteria
C7K70_09375	COG2233	PERMEase
C7K70_09385	COG1252	NADH dehydrogenase
C7K70_09405	COG0393	Putative heavy-metal-binding
C7K70_09415	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7K70_09420	COG1368	sulfuric ester hydrolase activity
C7K70_09430	COG0527	aspartate kinase activity
C7K70_09435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7K70_09435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7K70_09440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K70_09465	COG0596	Alpha beta hydrolase
C7K70_09470	COG0346	lactoylglutathione lyase activity
C7K70_09480	COG0583	DNA-binding transcription factor activity
C7K70_09485	COG1620	l-lactate permease
C7K70_09495	COG1139	Iron-sulfur cluster binding protein
C7K70_09525	COG1136	(ABC) transporter
C7K70_09535	COG2814	Major facilitator Superfamily
C7K70_09555	COG0672	)-iron permease
C7K70_09585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09595	COG2314	TM2 domain
C7K70_09605	COG0582	viral genome integration into host DNA
C7K70_09665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09750	COG1074	ATP-dependent DNA helicase activity
C7K70_09770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_09785	COG2314	TM2 domain
C7K70_09795	COG0582	viral genome integration into host DNA
C7K70_09820	COG3617	BRO family, N-terminal domain
C7K70_09865	COG0659	secondary active sulfate transmembrane transporter activity
C7K70_09890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_09895	COG0840	transmembrane signaling receptor activity
C7K70_09905	COG2201	protein-glutamate methylesterase activity
C7K70_09915	COG0835	chemotaxis
C7K70_09920	COG0840	transmembrane signaling receptor activity
C7K70_09920	COG3290	protein histidine kinase activity
C7K70_09925	COG0643	Histidine kinase
C7K70_09925	COG2198	Histidine kinase
C7K70_09935	COG0745	RESPONSE REGULATOR receiver
C7K70_09940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C7K70_09945	COG0437	4 iron, 4 sulfur cluster binding
C7K70_09950	COG5557	Pfam Polysulphide reductase, NrfD
C7K70_09955	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C7K70_09960	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C7K70_09965	COG1773	rubredoxin
C7K70_09975	COG0601	transmembrane transport
C7K70_09980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_09985	COG0444	Belongs to the ABC transporter superfamily
C7K70_09990	COG3842	ATPase activity
C7K70_09995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C7K70_10000	COG0375	protein maturation
C7K70_10005	COG0309	Hydrogenase expression formation protein (HypE)
C7K70_10015	COG0298	carbon dioxide binding
C7K70_10020	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C7K70_10030	COG1921	L-seryl-tRNASec selenium transferase activity
C7K70_10035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C7K70_10045	COG3260	NADH ubiquinone oxidoreductase 20
C7K70_10050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_10055	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C7K70_10055	COG3261	NADH dehydrogenase
C7K70_10060	COG0650	Formate hydrogenlyase subunit 4
C7K70_10065	COG0651	ATP synthesis coupled electron transport
C7K70_10070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_10075	COG3158	transport of potassium into the cell
C7K70_10080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_10110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7K70_10120	COG0326	Molecular chaperone. Has ATPase activity
C7K70_10130	COG0563	adenylate kinase activity
C7K70_10135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7K70_10145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_10160	COG3300	MHYT domain
C7K70_10160	COG5001	Diguanylate cyclase
C7K70_10165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_10185	COG1021	2,3-dihydroxybenzoate-AMP ligase
C7K70_10190	COG1535	isochorismatase
C7K70_10190	COG3433	isochorismatase activity
C7K70_10195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K70_10200	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_10210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K70_10215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7K70_10225	COG1120	ATPase activity
C7K70_10230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_10235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_10240	COG4771	TonB-dependent receptor
C7K70_10260	COG0598	Magnesium transport protein CorA
C7K70_10285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7K70_10290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7K70_10295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_10300	COG0840	transmembrane signaling receptor activity
C7K70_10310	COG1570	exodeoxyribonuclease VII activity
C7K70_10315	COG0697	spore germination
C7K70_10335	COG3158	transport of potassium into the cell
C7K70_10340	COG0517	IMP dehydrogenase activity
C7K70_10340	COG0516	GMP reductase activity
C7K70_10345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K70_10345	COG0519	Catalyzes the synthesis of GMP from XMP
C7K70_10380	COG2062	phosphohistidine phosphatase, SixA
C7K70_10390	COG0697	spore germination
C7K70_10395	COG4166	transmembrane transport
C7K70_10400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C7K70_10405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7K70_10415	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7K70_10420	COG1136	(ABC) transporter
C7K70_10425	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7K70_10430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C7K70_10445	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7K70_10450	COG0740	serine-type endopeptidase activity
C7K70_10455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7K70_10460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7K70_10465	COG0776	regulation of translation
C7K70_10470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K70_10475	COG0488	(ABC) transporter
C7K70_10480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7K70_10485	COG3162	membrane
C7K70_10500	COG1024	Enoyl-CoA hydratase
C7K70_10505	COG1115	amino acid carrier protein
C7K70_10520	COG1584	GPR1 FUN34 yaaH family protein
C7K70_10555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7K70_10560	COG1960	acyl-CoA dehydrogenase activity
C7K70_10570	COG1960	acyl-CoA dehydrogenase activity
C7K70_10575	COG1024	Enoyl-CoA hydratase
C7K70_10580	COG1024	Enoyl-CoA hydratase
C7K70_10590	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_10600	COG0730	response to heat
C7K70_10615	COG3706	GGDEF domain
C7K70_10620	COG0583	DNA-binding transcription factor activity
C7K70_10625	COG2723	6-phospho-beta-galactosidase activity
C7K70_10630	COG3300	MHYT domain
C7K70_10630	COG5001	Diguanylate cyclase
C7K70_10640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_10650	COG0583	DNA-binding transcription factor activity
C7K70_10655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7K70_10660	COG0673	inositol 2-dehydrogenase activity
C7K70_10665	COG0583	DNA-binding transcription factor activity
C7K70_10675	COG1560	Kdo2-lipid A biosynthetic process
C7K70_10680	COG1560	Kdo2-lipid A biosynthetic process
C7K70_10705	COG0417	DNA replication proofreading
C7K70_10735	COG0534	Mate efflux family protein
C7K70_10745	COG0307	riboflavin synthase, alpha
C7K70_10755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_10760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C7K70_10765	COG0697	spore germination
C7K70_10770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C7K70_10810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K70_10820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C7K70_10825	COG2894	cell division
C7K70_10830	COG0850	regulation of cytokinetic process
C7K70_10835	COG3100	YcgL domain-containing protein
C7K70_10840	COG2951	lytic endotransglycosylase activity
C7K70_10845	COG1760	l-serine dehydratase
C7K70_10855	COG1760	l-serine dehydratase
C7K70_10860	COG3123	guanosine phosphorylase activity
C7K70_10990	COG5301	cellulose 1,4-beta-cellobiosidase activity
C7K70_11015	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C7K70_11020	COG2067	long-chain fatty acid transport protein
C7K70_11025	COG2067	long-chain fatty acid transport protein
C7K70_11035	COG1595	DNA-templated transcription, initiation
C7K70_11065	COG0714	Associated with various cellular activities
C7K70_11070	COG0183	Belongs to the thiolase family
C7K70_11075	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7K70_11075	COG1024	Enoyl-CoA hydratase
C7K70_11085	COG4681	YaeQ
C7K70_11100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7K70_11105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7K70_11110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K70_11120	COG0549	Belongs to the carbamate kinase family
C7K70_11125	COG0697	spore germination
C7K70_11130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7K70_11130	COG3608	succinylglutamate desuccinylase aspartoacylase
C7K70_11135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7K70_11140	COG2068	MobA-Related Protein
C7K70_11145	COG0493	'glutamate synthase
C7K70_11145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_11150	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_11155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C7K70_11160	COG2080	2 iron, 2 sulfur cluster binding
C7K70_11160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7K70_11165	COG2233	PERMEase
C7K70_11170	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_11175	COG2252	PERMEase
C7K70_11180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7K70_11185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C7K70_11190	COG2080	2 iron, 2 sulfur cluster binding
C7K70_11200	COG3134	Outer membrane lipoprotein
C7K70_11210	COG1288	antiporter activity
C7K70_11215	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_11220	COG0140	phosphoribosyl-ATP diphosphatase activity
C7K70_11220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7K70_11225	COG0107	imidazoleglycerol-phosphate synthase activity
C7K70_11230	COG2205	protein histidine kinase activity
C7K70_11230	COG2198	Histidine kinase
C7K70_11230	COG0784	Response regulator, receiver
C7K70_11240	COG3437	response regulator, receiver
C7K70_11245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7K70_11250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7K70_11255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7K70_11255	COG0131	Imidazoleglycerol-phosphate dehydratase
C7K70_11260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7K70_11265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7K70_11270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7K70_11280	COG1199	ATP-dependent helicase activity
C7K70_11290	COG1214	PFAM Peptidase M22, glycoprotease
C7K70_11300	COG0596	Alpha beta hydrolase
C7K70_11300	COG2226	methyltransferase
C7K70_11300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7K70_11305	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_11325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K70_11330	COG2832	Protein of unknown function (DUF454)
C7K70_11335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K70_11345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7K70_11370	COG1643	Atp-dependent helicase
C7K70_11380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7K70_11390	COG3437	response regulator, receiver
C7K70_11395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7K70_11400	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C7K70_11405	COG0709	Synthesizes selenophosphate from selenide and ATP
C7K70_11420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K70_11430	COG1254	Belongs to the acylphosphatase family
C7K70_11435	COG0625	glutathione transferase activity
C7K70_11440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_11440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_11445	COG0489	protein tyrosine kinase activity
C7K70_11450	COG0572	uridine kinase
C7K70_11455	COG0717	Belongs to the dCTP deaminase family
C7K70_11465	COG0306	phosphate transporter
C7K70_11470	COG1530	ribonuclease E activity
C7K70_11475	COG0564	pseudouridine synthase activity
C7K70_11480	COG0546	phosphoglycolate phosphatase activity
C7K70_11485	COG0424	maF-like protein
C7K70_11490	COG2814	Major facilitator Superfamily
C7K70_11505	COG1399	metal-binding, possibly nucleic acid-binding protein
C7K70_11510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K70_11515	COG0416	fatty acid biosynthetic process
C7K70_11520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K70_11530	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K70_11540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K70_11545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K70_11550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7K70_11555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7K70_11560	COG0470	DNA polymerase III
C7K70_11565	COG0084	hydrolase, TatD family'
C7K70_11580	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C7K70_11580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_11585	COG3008	intermembrane lipid transfer
C7K70_11590	COG2995	paraquat-inducible protein a
C7K70_11600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C7K70_11605	COG0372	Belongs to the citrate synthase family
C7K70_11650	COG4221	oxidoreductase activity
C7K70_11660	COG3141	response to X-ray
C7K70_11685	COG4128	Pfam Zonular occludens toxin
C7K70_11725	COG1067	ATP-dependent peptidase activity
C7K70_11730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K70_11755	COG0116	Belongs to the methyltransferase superfamily
C7K70_11755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K70_11765	COG0167	dihydroorotate dehydrogenase activity
C7K70_11770	COG2902	Dehydrogenase
C7K70_11780	COG0308	aminopeptidase N
C7K70_11790	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C7K70_11795	COG1956	GAF domain-containing protein
C7K70_11805	COG3278	Belongs to the heme-copper respiratory oxidase family
C7K70_11820	COG2010	Cytochrome c
C7K70_11845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K70_11850	COG0589	response to stress
C7K70_11855	COG0037	tRNA processing
C7K70_11875	COG1869	D-ribose catabolic process
C7K70_11880	COG1129	ABC transporter
C7K70_11885	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K70_11890	COG1879	ABC-type sugar transport system periplasmic component
C7K70_11895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_11900	COG1609	Transcriptional regulator
C7K70_11905	COG3300	MHYT domain
C7K70_11905	COG5001	Diguanylate cyclase
C7K70_11915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7K70_11935	COG0776	regulation of translation
C7K70_11940	COG0072	phenylalanine-tRNA ligase activity
C7K70_11940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_11945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7K70_11950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7K70_11955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7K70_11960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7K70_11965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K70_11985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7K70_11995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_12000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_12005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_12010	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C7K70_12015	COG3313	Fe-S protein
C7K70_12025	COG3716	PTS system mannose fructose sorbose family IID component
C7K70_12030	COG3715	PTS system
C7K70_12035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_12035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_12050	COG1609	Transcriptional regulator
C7K70_12055	COG2140	Oxalate decarboxylase
C7K70_12060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_12060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_12060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C7K70_12065	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K70_12070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_12070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_12075	COG1609	Transcriptional regulator
C7K70_12080	COG0814	amino acid
C7K70_12090	COG5654	RES domain protein
C7K70_12095	COG0513	Belongs to the DEAD box helicase family
C7K70_12105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7K70_12110	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K70_12115	COG2840	Smr protein MutS2
C7K70_12145	COG2824	Alkylphosphonate utilization operon protein PhnA
C7K70_12160	COG0384	phenazine biosynthesis protein PhzF
C7K70_12190	COG0242	peptide deformylase activity
C7K70_12210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C7K70_12215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C7K70_12225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7K70_12230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C7K70_12240	COG0205	6-phosphofructokinase activity
C7K70_12245	COG1473	amidohydrolase
C7K70_12250	COG1011	Hydrolase
C7K70_12255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_12305	COG3593	DNA synthesis involved in DNA repair
C7K70_12320	COG0583	DNA-binding transcription factor activity
C7K70_12325	COG0730	response to heat
C7K70_12340	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K70_12350	COG0386	Belongs to the glutathione peroxidase family
C7K70_12355	COG0513	Belongs to the DEAD box helicase family
C7K70_12360	COG0456	acetyltransferase
C7K70_12370	COG1742	UPF0060 membrane protein
C7K70_12400	COG2329	Antibiotic biosynthesis monooxygenase
C7K70_12405	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C7K70_12425	COG3243	poly(R)-hydroxyalkanoic acid synthase
C7K70_12435	COG2501	S4 domain
C7K70_12450	COG1132	(ABC) transporter
C7K70_12460	COG1132	(ABC) transporter
C7K70_12470	COG3118	belongs to the thioredoxin family
C7K70_12475	COG0471	metal ion transport
C7K70_12480	COG0058	SHG alpha-glucan phosphorylase activity
C7K70_12520	COG0814	amino acid
C7K70_12525	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C7K70_12530	COG0514	ATP-dependent DNA helicase (RecQ)
C7K70_12535	COG2766	serine protein kinase
C7K70_12545	COG2719	SpoVR family
C7K70_12550	COG2186	Transcriptional regulator
C7K70_12555	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_12560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C7K70_12565	COG0586	Pfam SNARE associated Golgi protein
C7K70_12575	COG0556	nucleotide-excision repair
C7K70_12590	COG0569	domain protein
C7K70_12590	COG2985	domain, Protein
C7K70_12595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C7K70_12615	COG4565	transcriptional regulatory protein
C7K70_12620	COG3290	protein histidine kinase activity
C7K70_12625	COG1846	Transcriptional regulator
C7K70_12625	COG1940	carbohydrate kinase activity
C7K70_12630	COG0840	transmembrane signaling receptor activity
C7K70_12635	COG3012	SEC-C Motif Domain Protein
C7K70_12640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7K70_12645	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C7K70_12650	COG0247	lactate metabolic process
C7K70_12660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C7K70_12665	COG0437	4 iron, 4 sulfur cluster binding
C7K70_12670	COG3301	Polysulphide reductase, NrfD
C7K70_12675	COG1138	Cytochrome C-type biogenesis protein
C7K70_12680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_12685	COG3088	subunit of a heme lyase
C7K70_12685	COG4235	cytochrome complex assembly
C7K70_12690	COG1051	belongs to the nudix hydrolase family
C7K70_12700	COG3033	Beta-eliminating lyase
C7K70_12710	COG3046	protein related to deoxyribodipyrimidine photolyase
C7K70_12715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_12740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K70_12745	COG0583	DNA-binding transcription factor activity
C7K70_12755	COG4774	siderophore transport
C7K70_12760	COG4977	sequence-specific DNA binding
C7K70_12770	COG0583	DNA-binding transcription factor activity
C7K70_12775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_12790	COG0612	Peptidase, M16
C7K70_12795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K70_12800	COG2076	Multidrug Resistance protein
C7K70_12805	COG1944	ATP diphosphatase activity
C7K70_12810	COG2116	formate transmembrane transporter activity
C7K70_12815	COG1882	Formate acetyltransferase
C7K70_12820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_12830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C7K70_12840	COG1840	ABC-type Fe3 transport system, periplasmic component
C7K70_12845	COG3842	ATPase activity
C7K70_12855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_12860	COG2983	Belongs to the UPF0260 family
C7K70_12865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7K70_12870	COG0045	succinate-CoA ligase (ADP-forming) activity
C7K70_12875	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K70_12880	COG0567	Dehydrogenase, E1 component
C7K70_12890	COG1053	succinate dehydrogenase
C7K70_12895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C7K70_12900	COG2009	succinate dehydrogenase
C7K70_12920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K70_12925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C7K70_12925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_12935	COG3069	C4-dicarboxylate transmembrane transporter activity
C7K70_12950	COG1451	nucleotide metabolic process
C7K70_12965	COG0254	rRNA binding
C7K70_12970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K70_12980	COG0583	DNA-binding transcription factor activity
C7K70_12990	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K70_13000	COG1879	ABC-type sugar transport system periplasmic component
C7K70_13005	COG1069	ribulokinase activity
C7K70_13015	COG2160	L-arabinose isomerase activity
C7K70_13020	COG2925	Exonuclease
C7K70_13030	COG3345	alpha-galactosidase
C7K70_13035	COG1380	Effector of murein hydrolase LrgA
C7K70_13040	COG1346	cytolysis
C7K70_13045	COG0295	cytidine deaminase activity
C7K70_13065	COG0861	Integral membrane protein TerC family
C7K70_13070	COG2885	chlorophyll binding
C7K70_13075	COG2199	diguanylate cyclase activity
C7K70_13095	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7K70_13105	COG3768	UPF0283 membrane protein
C7K70_13110	COG3106	COG3106 Predicted ATPase
C7K70_13125	COG1842	Phage shock protein A
C7K70_13130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K70_13140	COG4168	peptide transport system, permease
C7K70_13145	COG4171	peptide transport system, permease
C7K70_13155	COG4172	Belongs to the ABC transporter superfamily
C7K70_13165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C7K70_13170	COG1286	toxin biosynthetic process
C7K70_13175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7K70_13185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K70_13190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C7K70_13195	COG1674	ftsk spoiiie
C7K70_13195	COG0531	amino acid
C7K70_13205	COG0686	Belongs to the AlaDH PNT family
C7K70_13210	COG0492	ferredoxin-NADP+ reductase activity
C7K70_13215	COG3706	GGDEF domain
C7K70_13220	COG3134	Outer membrane lipoprotein
C7K70_13225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C7K70_13230	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C7K70_13235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7K70_13240	COG0542	response to heat
C7K70_13245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C7K70_13250	COG1278	Cold shock
C7K70_13255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7K70_13285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_13290	COG0861	Integral membrane protein TerC family
C7K70_13300	COG0444	Belongs to the ABC transporter superfamily
C7K70_13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_13310	COG0601	transmembrane transport
C7K70_13320	COG2095	MarC family integral membrane protein
C7K70_13330	COG1454	alcohol dehydrogenase
C7K70_13330	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_13335	COG2199	diguanylate cyclase activity
C7K70_13335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_13340	COG3275	phosphorelay sensor kinase activity
C7K70_13345	COG3279	Response regulator of the LytR AlgR family
C7K70_13350	COG1966	Carbon starvation protein
C7K70_13360	COG1566	PFAM secretion protein HlyD family protein
C7K70_13365	COG1061	Type III restriction enzyme res subunit
C7K70_13370	COG2027	D-alanyl-D-alanine carboxypeptidase
C7K70_13375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7K70_13385	COG0436	Aminotransferase
C7K70_13390	COG1288	antiporter activity
C7K70_13395	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K70_13415	COG0697	spore germination
C7K70_13420	COG4657	Part of a membrane complex involved in electron transport
C7K70_13425	COG2878	Part of a membrane complex involved in electron transport
C7K70_13430	COG4656	Part of a membrane complex involved in electron transport
C7K70_13435	COG4658	electron transport chain
C7K70_13440	COG4659	FMN binding
C7K70_13450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K70_13455	COG0346	lactoylglutathione lyase activity
C7K70_13470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7K70_13475	COG2056	Na+-H+ antiporter family
C7K70_13485	COG2050	protein possibly involved in aromatic compounds catabolism
C7K70_13495	COG0277	FAD linked oxidase domain protein
C7K70_13495	COG0247	lactate metabolic process
C7K70_13505	COG1253	flavin adenine dinucleotide binding
C7K70_13510	COG1902	pentaerythritol trinitrate reductase activity
C7K70_13515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7K70_13520	COG0647	UMP catabolic process
C7K70_13525	COG4651	solute:proton antiporter activity
C7K70_13525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7K70_13535	COG0367	asparagine synthase
C7K70_13545	COG0625	glutathione transferase activity
C7K70_13550	COG0625	glutathione transferase activity
C7K70_13560	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C7K70_13575	COG0564	pseudouridine synthase activity
C7K70_13580	COG5001	Diguanylate cyclase
C7K70_13585	COG0840	transmembrane signaling receptor activity
C7K70_13595	COG0392	lysyltransferase activity
C7K70_13595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7K70_13605	COG2194	sulfuric ester hydrolase activity
C7K70_13620	COG1317	bacterial-type flagellum organization
C7K70_13775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C7K70_13780	COG4790	Type iii secretion
C7K70_13785	COG4794	Type iii secretion
C7K70_13790	COG4791	protein targeting
C7K70_13795	COG4792	protein secretion
C7K70_13805	COG0582	viral genome integration into host DNA
C7K70_13870	COG3209	COG3209 Rhs family protein
C7K70_13915	COG3501	Rhs element vgr protein
C7K70_13950	COG0670	Belongs to the BI1 family
C7K70_13955	COG1289	transmembrane transporter activity
C7K70_13960	COG2920	part of a sulfur-relay system
C7K70_13965	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C7K70_13970	COG0285	dihydrofolate synthase activity
C7K70_13975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7K70_13980	COG0101	tRNA pseudouridine synthase activity
C7K70_13990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K70_13995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K70_14000	COG0671	phosphoesterase, PA-phosphatase related
C7K70_14005	COG1464	Belongs to the NlpA lipoprotein family
C7K70_14045	COG0574	Belongs to the PEP-utilizing enzyme family
C7K70_14045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K70_14050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K70_14075	COG2304	oxidoreductase activity
C7K70_14115	COG1242	4 iron, 4 sulfur cluster binding
C7K70_14125	COG0067	glutamate synthase
C7K70_14125	COG0070	glutamate synthase
C7K70_14125	COG0069	glutamate synthase activity
C7K70_14130	COG0493	'glutamate synthase
C7K70_14140	COG0765	amino acid transport
C7K70_14145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_14160	COG0789	Transcriptional regulator
C7K70_14175	COG4104	PAAR repeat-containing protein
C7K70_14185	COG0513	Belongs to the DEAD box helicase family
C7K70_14190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_14220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7K70_14225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K70_14230	COG0505	Belongs to the CarA family
C7K70_14235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7K70_14250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7K70_14255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7K70_14260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K70_14265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7K70_14270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_14280	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C7K70_14290	COG2205	protein histidine kinase activity
C7K70_14290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_14305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_14330	COG0023	Translation Initiation Factor
C7K70_14335	COG2119	membrane
C7K70_14365	COG2203	Gaf domain
C7K70_14365	COG2199	diguanylate cyclase activity
C7K70_14385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K70_14395	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_14400	COG3301	Polysulphide reductase, NrfD
C7K70_14405	COG0437	4 iron, 4 sulfur cluster binding
C7K70_14410	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C7K70_14455	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C7K70_14480	COG0322	excinuclease ABC activity
C7K70_14485	COG2197	response regulator
C7K70_14490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C7K70_14495	COG2835	tetraacyldisaccharide 4'-kinase activity
C7K70_14500	COG1663	tetraacyldisaccharide 4'-kinase activity
C7K70_14505	COG1132	(ABC) transporter
C7K70_14510	COG0658	competence protein
C7K70_14510	COG2333	competence protein COMEC
C7K70_14525	COG0433	COG0433 Predicted ATPase
C7K70_14530	COG1448	Aminotransferase
C7K70_14540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C7K70_14545	COG1199	ATP-dependent helicase activity
C7K70_14555	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7K70_14560	COG0477	Major facilitator Superfamily
C7K70_14565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K70_14590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K70_14605	COG2271	Major facilitator Superfamily
C7K70_14610	COG3706	GGDEF domain
C7K70_14615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_14620	COG0765	amino acid transport
C7K70_14625	COG1126	abc transporter atp-binding protein
C7K70_14645	COG0531	amino acid
C7K70_14660	COG1253	flavin adenine dinucleotide binding
C7K70_14665	COG4974	Belongs to the 'phage' integrase family
C7K70_14735	COG4695	Portal protein
C7K70_14875	COG0704	Plays a role in the regulation of phosphate uptake
C7K70_14885	COG0581	inorganic phosphate transmembrane transporter activity
C7K70_14890	COG0573	inorganic phosphate transmembrane transporter activity
C7K70_14895	COG0590	tRNA wobble adenosine to inosine editing
C7K70_14905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C7K70_14925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7K70_14930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7K70_14935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7K70_14940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7K70_14945	COG2204	response regulator
C7K70_14950	COG3852	Histidine kinase
C7K70_14955	COG2204	response regulator
C7K70_14965	COG2716	regulation of RNA biosynthetic process
C7K70_14970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7K70_14975	COG0248	Ppx GppA phosphatase
C7K70_14980	COG2239	Acts as a magnesium transporter
C7K70_14990	COG1256	bacterial-type flagellum assembly
C7K70_15000	COG1706	bacterial-type flagellum-dependent cell motility
C7K70_15005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C7K70_15010	COG4786	Flagellar basal body rod
C7K70_15015	COG4787	bacterial-type flagellum-dependent cell motility
C7K70_15030	COG1558	bacterial-type flagellum-dependent cell motility
C7K70_15035	COG1815	bacterial-type flagellum-dependent cell motility
C7K70_15040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C7K70_15045	COG0835	chemotaxis
C7K70_15045	COG0784	Response regulator, receiver
C7K70_15050	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C7K70_15065	COG0622	Phosphoesterase
C7K70_15080	COG1187	pseudouridine synthase activity
C7K70_15095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K70_15100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_15110	COG1349	DNA-binding transcription factor activity
C7K70_15115	COG0697	spore germination
C7K70_15145	COG1278	Cold shock
C7K70_15185	COG3132	Protein of unknown function, DUF480
C7K70_15195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7K70_15205	COG0438	transferase activity, transferring glycosyl groups
C7K70_15210	COG1215	transferase activity, transferring glycosyl groups
C7K70_15225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K70_15240	COG0529	Catalyzes the synthesis of activated sulfate
C7K70_15245	COG0471	metal ion transport
C7K70_15245	COG0490	domain, Protein
C7K70_15250	COG2895	sulfate adenylyltransferase (ATP) activity
C7K70_15260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7K70_15265	COG1215	transferase activity, transferring glycosyl groups
C7K70_15300	COG1450	Type ii and iii secretion system protein
C7K70_15350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_15370	COG1091	dTDP-4-dehydrorhamnose reductase activity
C7K70_15380	COG1538	Outer membrane efflux protein
C7K70_15385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_15395	COG1309	transcriptional regulator
C7K70_15410	COG1946	Acyl-CoA thioesterase
C7K70_15420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7K70_15430	COG0009	L-threonylcarbamoyladenylate synthase
C7K70_15440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7K70_15445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7K70_15445	COG0512	Glutamine amidotransferase of anthranilate synthase
C7K70_15450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7K70_15455	COG0135	phosphoribosylanthranilate isomerase activity
C7K70_15455	COG0134	indole-3-glycerol-phosphate synthase activity
C7K70_15460	COG0133	tryptophan synthase activity
C7K70_15465	COG0159	tryptophan synthase activity
C7K70_15510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_15520	COG4521	taurine ABC transporter
C7K70_15525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C7K70_15530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7K70_15535	COG2175	clavaminate synthase activity
C7K70_15545	COG2814	Major facilitator Superfamily
C7K70_15550	COG0109	protoheme IX farnesyltransferase activity
C7K70_15555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C7K70_15560	COG1845	cytochrome c oxidase, subunit III
C7K70_15565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7K70_15570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7K70_15615	COG2211	Major facilitator Superfamily
C7K70_15630	COG0708	Exodeoxyribonuclease III
C7K70_15650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_15655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_15675	COG0095	Lipoate-protein ligase
C7K70_15705	COG0640	Transcriptional regulator
C7K70_15720	COG1285	pathogenesis
C7K70_15750	COG0484	heat shock protein binding
C7K70_15755	COG0443	Heat shock 70 kDa protein
C7K70_15760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7K70_15765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7K70_15770	COG0497	DNA recombination
C7K70_15775	COG1227	inorganic diphosphatase activity
C7K70_15785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_15790	COG1136	(ABC) transporter
C7K70_15790	COG0577	efflux transmembrane transporter activity
C7K70_15795	COG1538	Outer membrane efflux protein
C7K70_15800	COG2375	cellular response to nickel ion
C7K70_15810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_15830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_15835	COG1396	sequence-specific DNA binding
C7K70_15835	COG1917	Cupin 2, conserved barrel domain protein
C7K70_15850	COG0531	amino acid
C7K70_15860	COG0531	amino acid
C7K70_15870	COG1283	sodium-dependent phosphate transmembrane transporter activity
C7K70_15880	COG3384	dioxygenase
C7K70_15885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_15885	COG2205	protein histidine kinase activity
C7K70_15900	COG0813	purine-nucleoside phosphorylase activity
C7K70_15920	COG0488	(ABC) transporter
C7K70_15925	COG4319	ketosteroid isomerase
C7K70_15930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7K70_15935	COG0083	homoserine kinase activity
C7K70_15950	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C7K70_15955	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C7K70_15970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7K70_15980	COG0745	RESPONSE REGULATOR receiver
C7K70_15995	COG4988	ABC transporter
C7K70_16000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7K70_16020	COG1720	tRNA m6t6A37 methyltransferase activity
C7K70_16035	COG0542	response to heat
C7K70_16040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K70_16045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_16055	COG2190	(PTS) system
C7K70_16070	COG3038	cytochrome b561
C7K70_16085	COG0419	ATPase involved in DNA repair
C7K70_16090	COG0420	3'-5' exonuclease activity
C7K70_16100	COG2974	May be involved in recombination
C7K70_16110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7K70_16110	COG4651	solute:proton antiporter activity
C7K70_16125	COG0469	pyruvate kinase activity
C7K70_16130	COG1196	nuclear chromosome segregation
C7K70_16130	COG3264	Mechanosensitive ion channel
C7K70_16140	COG2706	6-phosphogluconolactonase activity
C7K70_16160	COG0281	malic enzyme
C7K70_16175	COG0437	4 iron, 4 sulfur cluster binding
C7K70_16180	COG3383	formate dehydrogenase (NAD+) activity
C7K70_16180	COG3383	formate dehydrogenase (NAD+) activity
C7K70_16210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7K70_16215	COG1910	domain protein
C7K70_16220	COG3852	Histidine kinase
C7K70_16225	COG2204	response regulator
C7K70_16235	COG4662	Binding-protein-dependent transport system inner membrane component
C7K70_16245	COG0746	molybdenum cofactor guanylyltransferase activity
C7K70_16250	COG0303	'Molybdopterin
C7K70_16255	COG1289	transmembrane transporter activity
C7K70_16260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_16290	COG3220	belongs to the UPF0276 family
C7K70_16330	COG4166	transmembrane transport
C7K70_16335	COG0601	transmembrane transport
C7K70_16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_16345	COG0444	Belongs to the ABC transporter superfamily
C7K70_16350	COG4608	Belongs to the ABC transporter superfamily
C7K70_16360	COG2971	BadF BadG BcrA BcrD
C7K70_16370	COG0840	transmembrane signaling receptor activity
C7K70_16385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K70_16390	COG3724	N-succinylarginine dihydrolase activity
C7K70_16395	COG0616	signal peptide processing
C7K70_16400	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_16405	COG0583	DNA-binding transcription factor activity
C7K70_16415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K70_16425	COG0583	DNA-binding transcription factor activity
C7K70_16435	COG1881	PFAM PEBP family protein
C7K70_16445	COG3408	Glycogen debranching enzyme
C7K70_16445	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C7K70_16450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K70_16455	COG0739	heme binding
C7K70_16460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C7K70_16490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7K70_16500	COG3091	SprT-like family
C7K70_16510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7K70_16515	COG0189	ligase activity
C7K70_16525	COG1678	Uncharacterized ACR, COG1678
C7K70_16530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7K70_16535	COG3104	oligopeptide transport
C7K70_16545	COG0714	Associated with various cellular activities
C7K70_16560	COG1115	amino acid carrier protein
C7K70_16565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K70_16580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7K70_16590	COG1301	dicarboxylic acid transport
C7K70_16600	COG2912	Transglutaminase-like superfamily
C7K70_16610	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K70_16615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7K70_16620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C7K70_16625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C7K70_16630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7K70_16640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K70_16645	COG0737	Belongs to the 5'-nucleotidase family
C7K70_16650	COG0193	aminoacyl-tRNA hydrolase activity
C7K70_16655	COG0012	GTP binding
C7K70_16700	COG0471	metal ion transport
C7K70_16700	COG0490	domain, Protein
C7K70_16735	COG0443	Heat shock 70 kDa protein
C7K70_16745	COG0366	Alpha amylase catalytic
C7K70_16770	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7K70_16770	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7K70_16770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7K70_16770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_16780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_16790	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_16800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7K70_16815	COG0180	Tryptophanyl-tRNA synthetase
C7K70_16825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K70_16830	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C7K70_16840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7K70_16845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7K70_16875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7K70_16880	COG0583	DNA-binding transcription factor activity
C7K70_16900	COG0583	DNA-binding transcription factor activity
C7K70_16915	COG0739	heme binding
C7K70_16925	COG3264	Mechanosensitive ion channel
C7K70_16925	COG1511	domain protein
C7K70_16930	COG0584	glycerophosphoryl diester phosphodiesterase
C7K70_16940	COG1053	succinate dehydrogenase
C7K70_16945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C7K70_16950	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C7K70_16975	COG3214	Protein conserved in bacteria
C7K70_17010	COG0745	RESPONSE REGULATOR receiver
C7K70_17015	COG0642	Histidine kinase
C7K70_17035	COG0516	GMP reductase activity
C7K70_17050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7K70_17055	COG3647	Membrane
C7K70_17065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K70_17075	COG3706	GGDEF domain
C7K70_17085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_17095	COG0583	DNA-binding transcription factor activity
C7K70_17100	COG3706	GGDEF domain
C7K70_17105	COG1278	Cold shock
C7K70_17115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_17120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7K70_17125	COG1702	phosphate starvation-inducible protein PhoH
C7K70_17130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7K70_17135	COG4535	Mg2 and Co2 transporter CorC
C7K70_17140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C7K70_17145	COG2888	peptidyl-tyrosine sulfation
C7K70_17150	COG0495	leucyl-tRNA aminoacylation
C7K70_17165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7K70_17170	COG0799	negative regulation of ribosome biogenesis
C7K70_17175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7K70_17180	COG0768	penicillin binding
C7K70_17185	COG0772	Belongs to the SEDS family
C7K70_17190	COG2951	lytic endotransglycosylase activity
C7K70_17200	COG1686	Belongs to the peptidase S11 family
C7K70_17205	COG2921	Belongs to the UPF0250 family
C7K70_17210	COG0321	lipoyl(octanoyl) transferase activity
C7K70_17220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7K70_17230	COG3545	Serine hydrolase
C7K70_17235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_17250	COG0789	Transcriptional regulator
C7K70_17260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_17265	COG1970	mechanosensitive ion channel activity
C7K70_17270	COG4974	Belongs to the 'phage' integrase family
C7K70_17275	COG0716	FMN binding
C7K70_17285	COG0312	modulator of DNA gyrase
C7K70_17290	COG0312	modulator of DNA gyrase
C7K70_17355	COG3275	phosphorelay sensor kinase activity
C7K70_17360	COG3279	Response regulator of the LytR AlgR family
C7K70_17365	COG1966	Carbon starvation protein
C7K70_17375	COG0114	fumarate hydratase activity
C7K70_17385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C7K70_17395	COG2211	Major facilitator Superfamily
C7K70_17400	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K70_17405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7K70_17410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7K70_17415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7K70_17420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7K70_17425	COG0195	Participates in both transcription termination and antitermination
C7K70_17430	COG0779	Required for maturation of 30S ribosomal subunits
C7K70_17445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K70_17450	COG0149	triose-phosphate isomerase activity
C7K70_17455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K70_17460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7K70_17465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7K70_17470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7K70_17475	COG1534	Rna-binding protein
C7K70_17485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K70_17490	COG1360	Flagellar Motor Protein
C7K70_17495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_17500	COG1722	exodeoxyribonuclease VII activity
C7K70_17505	COG0142	geranyltranstransferase activity
C7K70_17510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7K70_17535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K70_17540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C7K70_17545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_17550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7K70_17570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7K70_17570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7K70_17575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7K70_17585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7K70_17595	COG3381	protein complex oligomerization
C7K70_17615	COG5001	Diguanylate cyclase
C7K70_17615	COG3300	MHYT domain
C7K70_17625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7K70_17630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7K70_17635	COG0511	ligase activity, forming carbon-carbon bonds
C7K70_17640	COG0439	Biotin carboxylase
C7K70_17650	COG4145	pantothenate transmembrane transporter activity
C7K70_17655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_17655	COG2190	(PTS) system
C7K70_17655	COG1263	PTS System
C7K70_17660	COG0583	DNA-binding transcription factor activity
C7K70_17665	COG0604	alcohol dehydrogenase
C7K70_17675	COG2264	protein methyltransferase activity
C7K70_17690	COG0778	Nitroreductase
C7K70_17695	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_17695	COG1902	pentaerythritol trinitrate reductase activity
C7K70_17700	COG0616	signal peptide processing
C7K70_17720	COG3139	Protein of unknown function (DUF1315)
C7K70_17725	COG0252	asparaginase activity
C7K70_17730	COG0786	glutamate:sodium symporter activity
C7K70_17745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7K70_17750	COG0384	phenazine biosynthesis protein PhzF
C7K70_17755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7K70_17760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_17765	COG0175	sulfate reduction
C7K70_17775	COG2113	Glycine betaine
C7K70_17780	COG4176	ABC-type proline glycine betaine transport system permease component
C7K70_17785	COG4175	Glycine betaine
C7K70_17795	COG3610	response to peptide
C7K70_17800	COG2966	Psort location CytoplasmicMembrane, score
C7K70_17810	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7K70_17825	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_17835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K70_17860	COG2986	histidine ammonia-lyase
C7K70_17885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K70_17890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K70_17925	COG1858	cytochrome C peroxidase
C7K70_17935	COG2313	pseudouridylate synthase activity
C7K70_17940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_17945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_17945	COG2146	nitrite reductase [NAD(P)H] activity
C7K70_17950	COG2146	nitrite reductase [NAD(P)H] activity
C7K70_17950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_17955	COG1116	anion transmembrane transporter activity
C7K70_17960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7K70_17965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C7K70_17965	COG1116	anion transmembrane transporter activity
C7K70_17980	COG0243	molybdopterin cofactor binding
C7K70_18015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7K70_18035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C7K70_18050	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K70_18060	COG4608	Belongs to the ABC transporter superfamily
C7K70_18065	COG0444	Belongs to the ABC transporter superfamily
C7K70_18075	COG4239	(ABC) transporter, permease
C7K70_18080	COG4174	ABC transporter (Permease)
C7K70_18095	COG0811	peptide transport
C7K70_18100	COG0811	peptide transport
C7K70_18105	COG0848	biopolymer transport protein
C7K70_18155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_18160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_18165	COG0840	transmembrane signaling receptor activity
C7K70_18175	COG1278	Cold shock
C7K70_18215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C7K70_18225	COG0688	phosphatidylethanolamine metabolic process
C7K70_18230	COG4628	conserved protein (DUF2132)
C7K70_18245	COG3059	membrane
C7K70_18250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K70_18270	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C7K70_18275	COG3291	Pkd domain containing protein
C7K70_18275	COG4412	M6 family metalloprotease domain protein
C7K70_18340	COG1132	(ABC) transporter
C7K70_18350	COG1404	Belongs to the peptidase S8 family
C7K70_18355	COG2897	thiosulfate sulfurtransferase activity
C7K70_18360	COG2066	Belongs to the glutaminase family
C7K70_18365	COG3171	Protein conserved in bacteria
C7K70_18370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7K70_18375	COG2234	aminopeptidase activity
C7K70_18375	COG4935	Belongs to the peptidase S8 family
C7K70_18380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_18385	COG2200	EAL domain
C7K70_18390	COG1090	epimerase
C7K70_18395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C7K70_18400	COG4181	ATPase activity
C7K70_18405	COG2755	lipolytic protein G-D-S-L family
C7K70_18410	COG0835	chemotaxis
C7K70_18410	COG0784	Response regulator, receiver
C7K70_18420	COG0569	domain protein
C7K70_18420	COG2985	domain, Protein
C7K70_18425	COG1272	protein, Hemolysin III
C7K70_18430	COG0076	glutamate decarboxylase activity
C7K70_18435	COG2917	probably involved in intracellular septation
C7K70_18440	COG2350	Protein conserved in bacteria
C7K70_18450	COG1555	photosystem II stabilization
C7K70_18455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K70_18460	COG3104	oligopeptide transport
C7K70_18465	COG0745	RESPONSE REGULATOR receiver
C7K70_18495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_18510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C7K70_18515	COG1280	lysine exporter protein (LysE YggA)
C7K70_18545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K70_18550	COG0564	pseudouridine synthase activity
C7K70_18560	COG3300	MHYT domain
C7K70_18560	COG5001	Diguanylate cyclase
C7K70_18570	COG0459	protein refolding
C7K70_18575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7K70_18580	COG0534	Mate efflux family protein
C7K70_18585	COG3030	protein affecting phage T7 exclusion by the F plasmid
C7K70_18590	COG1027	Aspartate ammonia-lyase
C7K70_18595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C7K70_18605	COG0477	Major facilitator Superfamily
C7K70_18620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_18625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_18635	COG0673	inositol 2-dehydrogenase activity
C7K70_18645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7K70_18650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K70_18655	COG3036	rescue of stalled ribosome
C7K70_18660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7K70_18670	COG0138	bifunctional purine biosynthesis protein purh
C7K70_18675	COG0151	Belongs to the GarS family
C7K70_18700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7K70_18705	COG0358	DNA primase activity
C7K70_18710	COG1610	YqeY-like protein
C7K70_18715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7K70_18720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7K70_18730	COG1388	LysM domain
C7K70_18730	COG4942	peptidase
C7K70_18735	COG1238	metal cluster binding
C7K70_18740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7K70_18745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C7K70_18750	COG0585	pseudouridine synthase activity
C7K70_18760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7K70_18765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C7K70_18770	COG0148	phosphopyruvate hydratase activity
C7K70_18775	COG0504	CTP synthase activity
C7K70_18780	COG3956	TIGRFAM MazG family protein
C7K70_18785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K70_18790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_18800	COG4807	Protein conserved in bacteria
C7K70_18805	COG3023	N-Acetylmuramoyl-L-alanine amidase
C7K70_18815	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C7K70_18820	COG1381	Involved in DNA repair and RecF pathway recombination
C7K70_18830	COG0571	ribonuclease III activity
C7K70_18835	COG0681	Belongs to the peptidase S26 family
C7K70_18840	COG0481	GTPase activity
C7K70_18855	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C7K70_18860	COG1595	DNA-templated transcription, initiation
C7K70_18865	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C7K70_18875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C7K70_18915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_18925	COG0126	phosphoglycerate kinase activity
C7K70_18930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7K70_18935	COG1940	carbohydrate kinase activity
C7K70_18940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7K70_18955	COG4991	sh3 domain protein
C7K70_18960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K70_18975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C7K70_18980	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_18990	COG2982	Protein involved in outer membrane biogenesis
C7K70_18995	COG1505	serine-type exopeptidase activity
C7K70_19000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7K70_19005	COG0765	amino acid transport
C7K70_19010	COG0765	amino acid transport
C7K70_19015	COG1126	abc transporter atp-binding protein
C7K70_19020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_19025	COG0577	efflux transmembrane transporter activity
C7K70_19025	COG1136	(ABC) transporter
C7K70_19030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_19035	COG0745	RESPONSE REGULATOR receiver
C7K70_19040	COG2205	protein histidine kinase activity
C7K70_19045	COG2816	NAD+ diphosphatase activity
C7K70_19085	COG2070	2-Nitropropane dioxygenase
C7K70_19115	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C7K70_19150	COG0513	Belongs to the DEAD box helicase family
C7K70_19170	COG0154	amidase activity
C7K70_19175	COG2957	Belongs to the agmatine deiminase family
C7K70_19190	COG1902	pentaerythritol trinitrate reductase activity
C7K70_19230	COG3300	MHYT domain
C7K70_19230	COG5001	Diguanylate cyclase
C7K70_19240	COG0714	Associated with various cellular activities
C7K70_19250	COG0456	acetyltransferase
C7K70_19260	COG1022	Amp-dependent synthetase and ligase
C7K70_19270	COG2918	glutathione biosynthetic process
C7K70_19275	COG0612	Peptidase, M16
C7K70_19280	COG1238	metal cluster binding
C7K70_19305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_19310	COG0359	binds to the 23S rRNA
C7K70_19315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7K70_19320	COG0360	Binds together with S18 to 16S ribosomal RNA
C7K70_19325	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K70_19345	COG2153	protein acetylation
C7K70_19355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K70_19370	COG0557	exoribonuclease II activity
C7K70_19375	COG3706	GGDEF domain
C7K70_19380	COG1854	S-ribosylhomocysteine lyase activity
C7K70_19395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7K70_19395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7K70_19455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C7K70_19460	COG1047	Peptidyl-prolyl cis-trans
C7K70_19465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7K70_19470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7K70_19475	COG0196	riboflavin kinase activity
C7K70_19480	COG0728	peptidoglycan biosynthetic process
C7K70_19485	COG0268	Binds directly to 16S ribosomal RNA
C7K70_19490	COG0640	Transcriptional regulator
C7K70_19495	COG0583	DNA-binding transcription factor activity
C7K70_19505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_19510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7K70_19515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K70_19525	COG1051	belongs to the nudix hydrolase family
C7K70_19535	COG3066	DNA modification
C7K70_19545	COG0335	large ribosomal subunit rRNA binding
C7K70_19550	COG0336	Belongs to the RNA methyltransferase TrmD family
C7K70_19555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7K70_19560	COG0228	four-way junction DNA binding
C7K70_19565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7K70_19570	COG4137	Cytochrome C assembly protein
C7K70_19575	COG4536	flavin adenine dinucleotide binding
C7K70_19585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_19585	COG1017	nitric oxide dioxygenase activity
C7K70_19590	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C7K70_19595	COG0039	L-malate dehydrogenase activity
C7K70_19600	COG4160	amino acid transport
C7K70_19605	COG4215	(ABC) transporter
C7K70_19610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_19615	COG1126	abc transporter atp-binding protein
C7K70_19620	COG1438	arginine binding
C7K70_19625	COG2837	iron assimilation
C7K70_19630	COG3842	ATPase activity
C7K70_19640	COG1840	ABC-type Fe3 transport system, periplasmic component
C7K70_19645	COG0347	Belongs to the P(II) protein family
C7K70_19660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_19665	COG0583	DNA-binding transcription factor activity
C7K70_19680	COG1929	Belongs to the glycerate kinase type-1 family
C7K70_19685	COG2610	gluconate transmembrane transporter activity
C7K70_19690	COG3835	regulator
C7K70_19695	COG3112	Uncharacterised protein family (UPF0231)
C7K70_19710	COG0840	transmembrane signaling receptor activity
C7K70_19715	COG3568	Endonuclease Exonuclease Phosphatase
C7K70_19730	COG0513	Belongs to the DEAD box helicase family
C7K70_19770	COG1448	Aminotransferase
C7K70_19785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_19790	COG1328	CTP reductase activity
C7K70_19810	COG0793	Belongs to the peptidase S41A family
C7K70_19810	COG4946	Tricorn protease homolog
C7K70_19850	COG0840	transmembrane signaling receptor activity
C7K70_19855	COG3397	chitin binding
C7K70_19860	COG0583	DNA-binding transcription factor activity
C7K70_19870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7K70_19875	COG4208	sulfate ABC transporter
C7K70_19880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C7K70_19890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C7K70_19895	COG3174	membrane
C7K70_19900	COG0110	maltose O-acetyltransferase activity
C7K70_19925	COG0165	Argininosuccinate lyase
C7K70_19935	COG0137	argininosuccinate synthase activity
C7K70_19945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7K70_19950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7K70_19960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C7K70_19965	COG0527	aspartate kinase activity
C7K70_19965	COG0460	homoserine dehydrogenase
C7K70_19970	COG0626	cystathionine gamma-synthase activity
C7K70_19980	COG3708	Transcriptional regulator
C7K70_19980	COG2207	Transcriptional regulator
C7K70_19985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_19990	COG0814	amino acid
C7K70_19995	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7K70_20000	COG0494	nUDIX hydrolase
C7K70_20005	COG1011	Hydrolase
C7K70_20010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K70_20025	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C7K70_20035	COG3156	type II secretion system protein K
C7K70_20050	COG4795	General secretion pathway protein
C7K70_20055	COG2165	general secretion pathway protein
C7K70_20065	COG2165	general secretion pathway protein
C7K70_20070	COG1459	type II secretion system
C7K70_20075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_20085	COG3031	protein transport across the cell outer membrane
C7K70_20095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7K70_20120	COG0456	acetyltransferase
C7K70_20125	COG3133	Outer membrane lipoprotein
C7K70_20140	COG2771	luxR family
C7K70_20145	COG3916	Acyl-homoserine-lactone synthase
C7K70_20155	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C7K70_20160	COG1309	transcriptional regulator
C7K70_20170	COG2213	PTS system mannitol-specific
C7K70_20170	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_20175	COG0246	Mannitol dehydrogenase
C7K70_20180	COG3722	fumarate hydratase activity
C7K70_20185	COG3263	regulation of cellular component size
C7K70_20210	COG1671	Belongs to the UPF0178 family
C7K70_20225	COG1988	membrane-bound metal-dependent
C7K70_20230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_20235	COG0513	Belongs to the DEAD box helicase family
C7K70_20265	COG1575	Belongs to the MenA family. Type 1 subfamily
C7K70_20270	COG1169	isochorismate synthase
C7K70_20275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C7K70_20280	COG0596	Alpha beta hydrolase
C7K70_20285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7K70_20290	COG1441	menaquinone biosynthetic process
C7K70_20295	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_20310	COG3539	Fimbrial protein
C7K70_20320	COG3188	usher protein
C7K70_20330	COG3539	Fimbrial protein
C7K70_20340	COG3291	Pkd domain containing protein
C7K70_20345	COG2949	membrane
C7K70_20365	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C7K70_20370	COG5380	lipid catabolic process
C7K70_20385	COG4533	DNA binding
C7K70_20395	COG2873	o-acetylhomoserine
C7K70_20405	COG1979	alcohol dehydrogenase
C7K70_20425	COG4221	oxidoreductase activity
C7K70_20445	COG1285	pathogenesis
C7K70_20465	COG1368	sulfuric ester hydrolase activity
C7K70_20470	COG1522	sequence-specific DNA binding
C7K70_20480	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C7K70_20485	COG1418	mRNA catabolic process
C7K70_20490	COG1546	Belongs to the CinA family
C7K70_20490	COG1058	Belongs to the CinA family
C7K70_20500	COG1129	ABC transporter
C7K70_20500	COG0842	Transport permease protein
C7K70_20515	COG0561	phosphatase activity
C7K70_20520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7K70_20540	COG1011	Hydrolase
C7K70_20555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7K70_20560	COG0019	diaminopimelate decarboxylase activity
C7K70_20565	COG1965	Belongs to the frataxin family
C7K70_20575	COG3072	Adenylate cyclase
C7K70_20580	COG0181	hydroxymethylbilane synthase activity
C7K70_20590	COG2959	enzyme of heme biosynthesis
C7K70_20605	COG1494	fructose-1,6-bisphosphatase
C7K70_20645	COG1733	regulation of RNA biosynthetic process
C7K70_20665	COG3932	Exopolysaccharide synthesis, ExoD
C7K70_20670	COG0814	amino acid
C7K70_20675	COG3706	GGDEF domain
C7K70_20690	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C7K70_20710	COG2856	Zn peptidase
C7K70_20720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7K70_20725	COG2022	thiamine diphosphate biosynthetic process
C7K70_20735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7K70_20740	COG0352	thiamine-phosphate diphosphorylase activity
C7K70_20745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7K70_20750	COG0754	glutathionylspermidine amidase activity
C7K70_20760	COG3766	membrane
C7K70_20775	COG0745	RESPONSE REGULATOR receiver
C7K70_20785	COG1114	Component of the transport system for branched-chain amino acids
C7K70_20790	COG0189	ligase activity
C7K70_20815	COG1639	'signal transduction protein
C7K70_20825	COG2321	neutral zinc metallopeptidase
C7K70_20830	COG3700	Belongs to the class B bacterial acid phosphatase family
C7K70_20850	COG1366	Belongs to the anti-sigma-factor antagonist family
C7K70_20855	COG2172	sigma factor antagonist activity
C7K70_20860	COG0784	Response regulator, receiver
C7K70_20860	COG2205	protein histidine kinase activity
C7K70_20860	COG5002	protein histidine kinase activity
C7K70_20865	COG3437	response regulator, receiver
C7K70_20875	COG0477	Major facilitator Superfamily
C7K70_20890	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7K70_20895	COG1263	PTS System
C7K70_20895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_20915	COG0312	modulator of DNA gyrase
C7K70_20920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7K70_20935	COG3164	Protein of unknown function
C7K70_20940	COG1530	ribonuclease E activity
C7K70_20945	COG0424	maF-like protein
C7K70_20950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C7K70_20955	COG1792	Involved in formation and maintenance of cell shape
C7K70_20960	COG1077	Cell shape determining protein MreB Mrl
C7K70_20985	COG4968	Prepilin-type N-terminal cleavage methylation domain
C7K70_21005	COG1459	type II secretion system
C7K70_21010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_21060	COG2200	EAL domain
C7K70_21060	COG2199	diguanylate cyclase activity
C7K70_21065	COG2200	EAL domain
C7K70_21070	COG0387	Pfam Sodium calcium exchanger
C7K70_21075	COG2986	histidine ammonia-lyase
C7K70_21080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C7K70_21085	COG0010	Belongs to the arginase family
C7K70_21090	COG1228	amidohydrolase
C7K70_21095	COG2188	Transcriptional regulator
C7K70_21100	COG0288	reversible hydration of carbon dioxide
C7K70_21110	COG2177	Part of the ABC transporter FtsEX involved in
C7K70_21115	COG2884	Cell division ATP-binding protein ftsE
C7K70_21120	COG0552	protein localization to endoplasmic reticulum
C7K70_21125	COG0742	ribosomal rna small subunit methyltransferase
C7K70_21155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_21160	COG0741	lytic transglycosylase activity
C7K70_21180	COG2095	MarC family integral membrane protein
C7K70_21190	COG1301	dicarboxylic acid transport
C7K70_21215	COG3714	YhhN family
C7K70_21240	COG1770	oligopeptidase
C7K70_21255	COG4221	oxidoreductase activity
C7K70_21260	COG0583	DNA-binding transcription factor activity
C7K70_21265	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K70_21325	COG0203	ribosomal protein L17
C7K70_21330	COG0202	RNA polymerase activity
C7K70_21335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7K70_21340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7K70_21345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7K70_21350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K70_21355	COG0201	protein transport
C7K70_21360	COG0200	Binds to the 23S rRNA
C7K70_21365	COG1841	ribosomal large subunit assembly
C7K70_21370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7K70_21375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7K70_21380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7K70_21385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7K70_21390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7K70_21395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7K70_21400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7K70_21405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7K70_21410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7K70_21415	COG0255	Belongs to the universal ribosomal protein uL29 family
C7K70_21420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7K70_21425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7K70_21430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7K70_21435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7K70_21440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7K70_21445	COG0089	rRNA binding
C7K70_21450	COG0088	Forms part of the polypeptide exit tunnel
C7K70_21455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7K70_21460	COG0051	transcription antitermination factor activity, RNA binding
C7K70_21475	COG0745	RESPONSE REGULATOR receiver
C7K70_21480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K70_21485	COG2183	response to ionizing radiation
C7K70_21505	COG0596	Alpha beta hydrolase
C7K70_21510	COG1040	competence protein
C7K70_21515	COG0316	Belongs to the HesB IscA family
C7K70_21515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7K70_21520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7K70_21525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C7K70_21530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_21535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C7K70_21540	COG4942	peptidase
C7K70_21550	COG1609	Transcriptional regulator
C7K70_21555	COG0800	Aldolase
C7K70_21565	COG3265	gluconokinase activity
C7K70_21570	COG2610	gluconate transmembrane transporter activity
C7K70_21575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_21580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7K70_21590	COG0456	acetyltransferase
C7K70_21600	COG1490	D-aminoacyl-tRNA deacylase activity
C7K70_21605	COG1295	ribonuclease BN
C7K70_21615	COG0174	glutamine synthetase
C7K70_21625	COG3852	Histidine kinase
C7K70_21630	COG2204	response regulator
C7K70_21635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7K70_21640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K70_21650	COG3078	GTPase activator activity
C7K70_21665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7K70_21675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K70_21680	COG0408	coproporphyrinogen oxidase activity
C7K70_21685	COG0009	L-threonylcarbamoyladenylate synthase
C7K70_21695	COG0551	DNA topoisomerase type I activity
C7K70_21700	COG2922	Belongs to the Smg family
C7K70_21705	COG0758	DNA mediated transformation
C7K70_21715	COG0242	peptide deformylase activity
C7K70_21720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K70_21725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_21725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_21730	COG0569	domain protein
C7K70_21735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_21740	COG1322	Protein conserved in bacteria
C7K70_21760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_21765	COG0686	Belongs to the AlaDH PNT family
C7K70_21770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K70_21770	COG0519	Catalyzes the synthesis of GMP from XMP
C7K70_21785	COG1396	sequence-specific DNA binding
C7K70_21790	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_21800	COG2962	Rard protein
C7K70_21810	COG1280	lysine exporter protein (LysE YggA)
C7K70_21820	COG2391	methyltransferase activity
C7K70_21830	COG1280	lysine exporter protein (LysE YggA)
C7K70_21890	COG0210	DNA helicase
C7K70_21925	COG0583	DNA-binding transcription factor activity
C7K70_21945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7K70_21950	COG0385	Bile acid
C7K70_21955	COG0531	amino acid
C7K70_21960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_21965	COG0531	amino acid
C7K70_21970	COG2731	YhcH YjgK YiaL family protein
C7K70_21975	COG3250	beta-galactosidase activity
C7K70_21980	COG1609	Transcriptional regulator
C7K70_22015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7K70_22020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_22020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_22025	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C7K70_22030	COG3074	FtsZ-dependent cytokinesis
C7K70_22040	COG1045	serine acetyltransferase
C7K70_22050	COG0745	RESPONSE REGULATOR receiver
C7K70_22055	COG2205	protein histidine kinase activity
C7K70_22060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7K70_22065	COG0534	Mate efflux family protein
C7K70_22090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7K70_22095	COG2937	Belongs to the GPAT DAPAT family
C7K70_22100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7K70_22105	COG3161	chorismate lyase activity
C7K70_22110	COG1580	Controls the rotational direction of flagella during chemotaxis
C7K70_22130	COG0604	alcohol dehydrogenase
C7K70_22135	COG1609	Transcriptional regulator
C7K70_22155	COG1519	Transferase
C7K70_22160	COG0859	PFAM glycosyl transferase family 9
C7K70_22165	COG0463	Glycosyl transferase, family 2
C7K70_22170	COG0859	PFAM glycosyl transferase family 9
C7K70_22175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7K70_22180	COG2990	Protein conserved in bacteria
C7K70_22185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7K70_22195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K70_22200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7K70_22205	COG2003	Belongs to the UPF0758 family
C7K70_22210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7K70_22215	COG0756	dUTP diphosphatase activity
C7K70_22220	COG1309	transcriptional regulator
C7K70_22225	COG0668	transmembrane transport
C7K70_22240	COG0166	Belongs to the GPI family
C7K70_22245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7K70_22250	COG0583	DNA-binding transcription factor activity
C7K70_22265	COG0045	succinate-CoA ligase (ADP-forming) activity
C7K70_22265	COG1042	CoA-binding domain protein
C7K70_22265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_22295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7K70_22305	COG0583	DNA-binding transcription factor activity
C7K70_22320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7K70_22325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7K70_22330	COG2223	nitrite transmembrane transporter activity
C7K70_22335	COG3279	Response regulator of the LytR AlgR family
C7K70_22340	COG3275	phosphorelay sensor kinase activity
C7K70_22350	COG2223	nitrite transmembrane transporter activity
C7K70_22355	COG2081	HI0933 family
C7K70_22360	COG1528	Iron-storage protein
C7K70_22365	COG3706	GGDEF domain
C7K70_22370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K70_22375	COG0589	response to stress
C7K70_22415	COG3642	lipopolysaccharide core region biosynthetic process
C7K70_22420	COG0859	PFAM glycosyl transferase family 9
C7K70_22430	COG1758	RNA polymerase activity
C7K70_22435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K70_22440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K70_22445	COG2267	carboxylic ester hydrolase activity
C7K70_22450	COG0561	phosphatase activity
C7K70_22470	COG1840	ABC-type Fe3 transport system, periplasmic component
C7K70_22475	COG2271	Major facilitator Superfamily
C7K70_22480	COG0469	pyruvate kinase activity
C7K70_22510	COG1309	transcriptional regulator
C7K70_22515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_22520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_22525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_22525	COG4191	Histidine kinase
C7K70_22530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K70_22555	COG2205	protein histidine kinase activity
C7K70_22560	COG0745	RESPONSE REGULATOR receiver
C7K70_22565	COG2814	Major facilitator Superfamily
C7K70_22580	COG3977	Valine--pyruvate aminotransferase
C7K70_22585	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K70_22590	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K70_22595	COG2378	regulation of single-species biofilm formation
C7K70_22605	COG0187	DNA topoisomerase II activity
C7K70_22610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7K70_22615	COG0592	DNA-directed DNA polymerase activity
C7K70_22620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7K70_22635	COG1126	abc transporter atp-binding protein
C7K70_22640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7K70_22645	COG0594	ribonuclease P activity
C7K70_22650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7K70_22655	COG0706	membrane insertase activity
C7K70_22660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7K70_22675	COG1120	ATPase activity
C7K70_22680	COG4615	Cyclic peptide transporter
C7K70_22685	COG4774	siderophore transport
C7K70_22690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7K70_22695	COG0445	tRNA wobble uridine modification
C7K70_22700	COG0357	Ribosomal RNA small subunit methyltransferase G
C7K70_22705	COG1192	Involved in chromosome partitioning
C7K70_22710	COG1475	DNA binding
C7K70_22720	COG0356	it plays a direct role in the translocation of protons across the membrane
C7K70_22730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7K70_22735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K70_22740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7K70_22745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7K70_22750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7K70_22755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7K70_22760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7K70_22765	COG4452	Inner membrane protein CreD
C7K70_22775	COG2205	protein histidine kinase activity
C7K70_22780	COG0745	RESPONSE REGULATOR receiver
C7K70_22785	COG1349	DNA-binding transcription factor activity
C7K70_22790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7K70_22795	COG2771	luxR family
C7K70_22805	COG0811	peptide transport
C7K70_22810	COG0811	peptide transport
C7K70_22815	COG0848	biopolymer transport protein
C7K70_22820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C7K70_22870	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_22875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7K70_22885	COG3165	ubiquinone biosynthetic process from chorismate
C7K70_22890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C7K70_22900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7K70_22905	COG0805	protein transport
C7K70_22910	COG0084	hydrolase, TatD family'
C7K70_22930	COG0742	ribosomal rna small subunit methyltransferase
C7K70_22945	COG0248	Ppx GppA phosphatase
C7K70_22950	COG0513	Belongs to the DEAD box helicase family
C7K70_22955	COG3118	belongs to the thioredoxin family
C7K70_22960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7K70_22970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7K70_22995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_23025	COG0559	Belongs to the binding-protein-dependent transport system permease family
C7K70_23035	COG1609	Transcriptional regulator
C7K70_23050	COG2188	Transcriptional regulator
C7K70_23055	COG3604	Transcriptional regulator
C7K70_23060	COG0426	domain, Protein
C7K70_23060	COG1773	rubredoxin
C7K70_23065	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_23075	COG0348	domain, Protein
C7K70_23080	COG0814	amino acid
C7K70_23115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate