locus-tag	class	description
HFP99_00010	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
HFP99_00040	ENOG4107QWG	2-Nitropropane dioxygenase
HFP99_00070	ENOG4108NIW	Leucine export protein LeuE
HFP99_00125	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HFP99_00130	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_00170	ENOG4105I93	response regulator
HFP99_00175	ENOG4105DUX	Transporter
HFP99_00180	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HFP99_00185	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HFP99_00190	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HFP99_00195	ENOG4105K9H	YciI-like protein
HFP99_00200	ENOG4107835	probably involved in intracellular septation (By similarity)
HFP99_00205	ENOG4105DY8	decarboxylase
HFP99_00210	ENOG4108UT2	hemolysin iii
HFP99_00215	ENOG4105D0C	transport protein
HFP99_00245	ENOG4105EV4	Multidrug resistance protein mdtH
HFP99_00265	ENOG4105D9U	N-acetyltransferase
HFP99_00275	ENOG4105XEP	YhcH YjgK YiaL family protein
HFP99_00285	ENOG4105CUY	Mechanosensitive ion channel
HFP99_00290	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_00295	ENOG4105CK7	Sodium proline symporter
HFP99_00310	ENOG4108Z6Z	Transcriptional regulator
HFP99_00335	ENOG4105D6S	protein involved in catabolism of external DNA
HFP99_00345	ENOG4105C5H	ABC transporter
HFP99_00350	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_00355	ENOG4105FCK	Membrane
HFP99_00365	ENOG4108UJV	acyl-CoA thioesterase i
HFP99_00370	ENOG4108I0Y	(ABC) transporter
HFP99_00375	ENOG4105CV6	ABC transporter, permease
HFP99_00380	ENOG4105ECP	epimerase
HFP99_00385	ENOG4105BZU	Histidine kinase
HFP99_00390	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HFP99_00395	ENOG4105IIU	Aminopeptidase
HFP99_00400	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HFP99_00405	ENOG41090ED	Protein with unknown function (DUF469)
HFP99_00410	ENOG4105CSV	Glutaminase
HFP99_00415	ENOG4107RM6	sulfurtransferase
HFP99_00420	ENOG4105E3R	(LipO)protein
HFP99_00425	ENOG4108W78	Pfam:DUF1017
HFP99_00430	ENOG4108MDC	(LipO)protein
HFP99_00450	ENOG4105SUV	lipoprotein YgdR
HFP99_00480	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
HFP99_00485	ENOG4105BZU	Histidine kinase
HFP99_00505	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HFP99_00510	ENOG4105DJ4	phosphatidylserine decarboxylase
HFP99_00520	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HFP99_00560	ENOG4105VEQ	Cold shock protein
HFP99_00570	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_00575	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HFP99_00625	ENOG4109015	Biopolymer transport protein exbD tolR
HFP99_00650	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HFP99_00655	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HFP99_00670	ENOG4108JQ7	(ABC) transporter
HFP99_00675	ENOG4105CIN	aminoacyl-histidine dipeptidase
HFP99_00680	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HFP99_00685	ENOG4105V1F	Fermentation respiration switch protein
HFP99_00690	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HFP99_00700	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HFP99_00750	ENOG4105D7T	ABC transporter
HFP99_00755	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_00760	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_00770	ENOG4105DD7	kinase (PfkB family
HFP99_00775	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
HFP99_00785	ENOG4105CA0	peroxidase
HFP99_00800	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HFP99_00810	ENOG4105DWK	Membrane
HFP99_00815	ENOG4107XM3	UPF0442 protein
HFP99_00825	ENOG4108IJ7	Glycine betaine
HFP99_00830	ENOG4108HQS	Glycine betaine
HFP99_00840	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HFP99_00845	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HFP99_00850	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HFP99_00855	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HFP99_00860	ENOG4105CRK	lysyL-tRNA synthetase
HFP99_00870	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_00875	ENOG4105D6U	Sodium Glutamate Symporter
HFP99_00880	ENOG4105HDK	L-asparaginase
HFP99_00885	ENOG4105VUT	cytoplasmic protein
HFP99_00905	ENOG4105D07	Signal peptide peptidase, SppA
HFP99_00910	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_00915	ENOG41069NU	Nitroreductase
HFP99_00925	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HFP99_00930	ENOG4105CIS	alcohol dehydrogenase
HFP99_00935	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_00940	ENOG4105CI1	PTS System
HFP99_00945	ENOG4108IA2	Sodium pantothenate symporter
HFP99_00950	ENOG4105RG0	Membrane
HFP99_00955	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HFP99_00960	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HFP99_00965	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HFP99_00970	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HFP99_00985	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HFP99_00990	ENOG4108EM1	reductase
HFP99_00995	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_01000	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HFP99_01010	ENOG4105BZU	Histidine kinase
HFP99_01020	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HFP99_01030	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HFP99_01035	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HFP99_01050	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HFP99_01055	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HFP99_01060	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HFP99_01065	ENOG4108ZAI	phosphatidylglycerophosphatase a
HFP99_01070	ENOG4108JQ6	ABC transporter
HFP99_01080	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_01090	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HFP99_01095	ENOG4105CTB	Polyprenyl synthetase
HFP99_01100	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HFP99_01105	ENOG4105E14	MotA TolQ exbB proton channel
HFP99_01110	ENOG4107XSU	flagellar motor protein motb
HFP99_01120	ENOG4105CY3	ABC transporter, permease
HFP99_01125	ENOG4108IJ6	ABC transporter
HFP99_01145	ENOG4105T2N	Domain of unknown function (DUF2382)
HFP99_01150	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HFP99_01160	ENOG4105HBR	Rna-binding protein
HFP99_01165	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HFP99_01170	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HFP99_01175	ENOG4105EEI	dihydropteroate synthase
HFP99_01180	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HFP99_01185	ENOG4105CP7	Triose-phosphate isomerase
HFP99_01190	ENOG4105NTZ	Preprotein translocase subunit SecG
HFP99_01205	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HFP99_01210	ENOG4105CHV	Transcription elongation factor NusA
HFP99_01215	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HFP99_01220	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HFP99_01225	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HFP99_01230	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HFP99_01235	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HFP99_01240	ENOG4105E5W	Transporter
HFP99_01245	ENOG41090EX	DsrE family
HFP99_01250	ENOG4105WAY	exported protein
HFP99_01255	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HFP99_01260	ENOG4105CFP	Peptidase U32
HFP99_01265	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_01280	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HFP99_01285	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HFP99_01290	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HFP99_01305	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HFP99_01325	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_01335	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HFP99_01340	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HFP99_01345	ENOG4108Z43	UPF0250 protein
HFP99_01350	ENOG4105DZ1	carboxypeptidase
HFP99_01355	ENOG4105K6T	rare lipoprotein A
HFP99_01360	ENOG4105CVE	Lytic murein transglycosylase
HFP99_01365	ENOG4105CNI	cell division protein FtsW
HFP99_01370	ENOG4105CNI	cell division protein FtsW
HFP99_01375	ENOG4105CJN	penicillin-binding protein
HFP99_01380	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HFP99_01385	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HFP99_01390	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HFP99_01405	ENOG4105C8T	Leucyl-tRNA synthetase
HFP99_01410	ENOG4107PAI	alpha helical protein
HFP99_01415	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HFP99_01420	ENOG4108JU5	Magnesium and cobalt efflux protein
HFP99_01430	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HFP99_01435	ENOG4105C9A	Phoh family
HFP99_01440	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HFP99_01445	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HFP99_01455	ENOG4105F04	LysR family Transcriptional regulator
HFP99_01465	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_01475	ENOG4105BZU	Histidine kinase
HFP99_01485	ENOG4105C5I	Dehydrogenase
HFP99_01495	ENOG4108R5S	membrane
HFP99_01500	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HFP99_01510	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_01520	ENOG4105DHQ	Histidine kinase
HFP99_01525	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HFP99_01535	ENOG4108IXY	short-chain dehydrogenase reductase
HFP99_01545	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_01555	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HFP99_01560	ENOG4105T0Z	Conserved Protein
HFP99_01565	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HFP99_01570	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HFP99_01575	ENOG4105E33	succinate dehydrogenase
HFP99_01585	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_01590	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HFP99_01595	ENOG4105EGS	Mechanosensitive ion channel
HFP99_01605	ENOG4105DR5	peptidase
HFP99_01615	ENOG4108VEV	chaperone
HFP99_01625	ENOG4108VEV	chaperone
HFP99_01640	ENOG4105EJC	lysr family transcriptional regulator
HFP99_01655	ENOG4105C5Q	Transcriptional regulator
HFP99_01660	ENOG4108JQC	penicillin-binding protein 1A
HFP99_01685	ENOG4105E4G	Type IV pilus
HFP99_01690	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HFP99_01695	ENOG4105D49	3-dehydroquinate synthase
HFP99_01705	ENOG4105DFE	Dna adenine methylase
HFP99_01710	ENOG4105DJV	ribulose-phosphate 3-epimerase
HFP99_01715	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HFP99_01720	ENOG4105C31	Tryptophanyl-tRNA synthetase
HFP99_01735	ENOG4105C8Y	Acetylornithine aminotransferase
HFP99_01740	ENOG4105F4X	arginine
HFP99_01745	ENOG4105C26	Dehydrogenase
HFP99_01755	ENOG4107VXZ	Hydrolase
HFP99_01765	ENOG4107QF7	multi-drug
HFP99_01770	ENOG4105C5H	ABC transporter
HFP99_01780	ENOG4105CG3	alpha amylase, catalytic region
HFP99_01795	ENOG4105N5Z	UPF0267 protein
HFP99_01800	ENOG4107QWE	)-transporter
HFP99_01845	ENOG4105C3G	gtp-binding protein
HFP99_01855	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HFP99_01860	ENOG4105CGH	5'-nucleotidase
HFP99_01865	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HFP99_01875	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HFP99_01880	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HFP99_01885	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HFP99_01890	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HFP99_01895	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HFP99_01905	ENOG41063JG	Transcriptional regulator
HFP99_01910	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HFP99_01915	ENOG4105CK2	sodium dicarboxylate symporter
HFP99_01920	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HFP99_01940	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HFP99_01945	ENOG4105BZG	amino acid carrier protein
HFP99_01960	ENOG4105G2Y	Transcriptional regulator
HFP99_01965	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HFP99_01975	ENOG4105D7Z	glutathione synthase
HFP99_01980	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HFP99_01990	ENOG4105GPY	SprT protein
HFP99_01995	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HFP99_02000	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HFP99_02010	ENOG4105KME	endoribonuclease L-psp
HFP99_02015	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HFP99_02025	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HFP99_02030	ENOG4105DR5	peptidase
HFP99_02035	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HFP99_02040	ENOG4107WCA	isomerase
HFP99_02055	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HFP99_02085	ENOG4105XIQ	Protein of unknown function (DUF2517)
HFP99_02090	ENOG4105BZU	Histidine kinase
HFP99_02095	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HFP99_02100	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_02120	ENOG4105CUB	amino acid
HFP99_02125	ENOG4105CUB	amino acid
HFP99_02130	ENOG4108JPW	Aminotransferase
HFP99_02135	ENOG4105C26	Dehydrogenase
HFP99_02140	ENOG4107VRI	Transcriptional regulator
HFP99_02145	ENOG4105CJP	fad dependent oxidoreductase
HFP99_02185	ENOG4108UJV	acyl-CoA thioesterase i
HFP99_02190	ENOG4105DH7	May be involved in recombination (By similarity)
HFP99_02195	ENOG4105K5X	acetyltransferase
HFP99_02200	ENOG4107RH8	nuclease SbcCD subunit D
HFP99_02205	ENOG4105EYH	Exonuclease
HFP99_02210	ENOG4105CPW	cytochrome b561
HFP99_02215	ENOG4105C5Y	PTS System
HFP99_02220	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HFP99_02225	ENOG4105KZ7	phosphocarrier protein hpr
HFP99_02230	ENOG4105C6T	cysteine synthase
HFP99_02235	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HFP99_02255	ENOG4108R96	Methyltransferase, YaeB family
HFP99_02275	ENOG4108JJ8	(ABC) transporter
HFP99_02280	ENOG4108JJ9	ABC, transporter
HFP99_02295	ENOG41065U4	response regulator
HFP99_02305	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HFP99_02320	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HFP99_02325	ENOG4106FVC	RNA methyltransferase
HFP99_02335	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HFP99_02340	ENOG4105D98	threonine synthase
HFP99_02345	ENOG4108VSZ	Inherit from COG: ketosteroid isomerase-like protein
HFP99_02385	ENOG4107SDU	Methyl-accepting chemotaxis
HFP99_02395	ENOG4108ESY	Metal dependent phosphohydrolase
HFP99_02400	ENOG4105DR8	Membrane
HFP99_02405	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
HFP99_02410	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HFP99_02425	ENOG4105C2W	permease
HFP99_02440	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HFP99_02450	ENOG4105EGS	Mechanosensitive ion channel
HFP99_02455	ENOG4105CA9	Pyruvate kinase
HFP99_02460	ENOG4105EZE	Cupin 4 family protein
HFP99_02465	ENOG4107QTF	adenylosuccinate lyase
HFP99_02470	ENOG41075W9	High frequency lysogenization protein HflD homolog
HFP99_02475	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HFP99_02495	ENOG4108YRF	PTS System
HFP99_02500	ENOG4105CXY	transporter
HFP99_02505	ENOG4105DM4	PTS System
HFP99_02520	ENOG4107NQ8	LysR family Transcriptional regulator
HFP99_02530	ENOG4108NZE	NAGC-like transcriptional regulator
HFP99_02540	ENOG4107QNK	)-transporter
HFP99_02550	ENOG4107VGF	ig domain protein group 2 domain protein
HFP99_02555	ENOG4105DM4	PTS System
HFP99_02570	ENOG4105EIP	mannose-6-phosphate isomerase
HFP99_02575	ENOG4106R3P	AraC family transcriptional regulator
HFP99_02580	ENOG4108HMX	isocitrate dehydrogenase (NADP)
HFP99_02590	ENOG4105BZC	d-serine deaminase
HFP99_02595	ENOG4105C6Z	Gluconate
HFP99_02600	ENOG4105W8I	Transcriptional regulator
HFP99_02615	ENOG4105Q26	Siderophore-interacting protein
HFP99_02620	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HFP99_02625	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_02630	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HFP99_02640	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HFP99_02650	ENOG4105BZU	Histidine kinase
HFP99_02655	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HFP99_02660	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFP99_02665	ENOG4105CFG	Acts as a chaperone (By similarity)
HFP99_02670	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HFP99_02680	ENOG4105D7K	pfkb domain protein
HFP99_02695	ENOG4105WBN	Transcriptional regulator (LacI family
HFP99_02715	ENOG41080HT	Transcriptional regulator, arsr family
HFP99_02740	ENOG4105EFX	secretion protein, HlyD family
HFP99_02745	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_02750	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_02755	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_02760	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HFP99_02775	ENOG4108IJF	Heavy metal efflux pump, CzcA
HFP99_02780	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
HFP99_02790	ENOG4105CGK	Exodeoxyribonuclease III
HFP99_02805	ENOG4105VN1	Heat shock protein
HFP99_02815	ENOG41090JD	Blue (Type 1) copper domain protein
HFP99_02835	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_02840	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HFP99_02845	ENOG4105E2S	oxidase) subunit II
HFP99_02850	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HFP99_02855	ENOG4105CCU	oxidase (Subunit III)
HFP99_02860	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HFP99_02865	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HFP99_02875	ENOG4107RDB	Major Facilitator
HFP99_02880	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
HFP99_02890	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_02910	ENOG4105CAF	HipA N-terminal domain protein
HFP99_02930	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HFP99_02935	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HFP99_02940	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HFP99_02945	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HFP99_02950	ENOG4108EFP	Anthranilate synthase component II
HFP99_02955	ENOG4105CRQ	synthase (Component I)
HFP99_02960	ENOG4105DB7	PHP domain protein
HFP99_02965	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HFP99_02975	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HFP99_02980	ENOG4105FE9	pseudouridine synthase
HFP99_02985	ENOG4105C29	acyl-CoA thioesterase
HFP99_03000	ENOG4107XI7	Tetr family transcriptional regulator
HFP99_03005	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HFP99_03010	ENOG4105BZS	acriflavin resistance protein
HFP99_03015	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HFP99_03020	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_03030	ENOG4107SSZ	Phosphatase
HFP99_03040	ENOG4107QPN	acyl-Coa dehydrogenase
HFP99_03045	ENOG4105BZS	acriflavin resistance protein
HFP99_03055	ENOG4105CA9	Pyruvate kinase
HFP99_03060	ENOG4106KNT	transcriptional regulator
HFP99_03065	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HFP99_03070	ENOG4105IFJ	Histidine kinase
HFP99_03080	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HFP99_03085	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HFP99_03095	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HFP99_03150	ENOG4108RT7	Glycosyl transferase, family 2
HFP99_03160	ENOG4105D3Q	Sugar transferase
HFP99_03170	ENOG4108KPN	Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12)
HFP99_03185	ENOG4108YXG	UPF0502 protein
HFP99_03195	ENOG4105KR1	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)
HFP99_03210	ENOG4107RUY	(E1 component), alpha subunit
HFP99_03215	ENOG4105CPP	Dehydrogenase, E1 component
HFP99_03220	ENOG4107QSN	dihydrolipoamide acetyltransferase
HFP99_03225	ENOG4105VEQ	Cold shock protein
HFP99_03255	ENOG4108594	Permease of the drug metabolite transporter
HFP99_03265	ENOG4105CPI	Metal Dependent Phosphohydrolase
HFP99_03270	ENOG4105I08	Pseudouridine synthase
HFP99_03280	ENOG4107QSI	ABC, transporter
HFP99_03285	ENOG4108RE9	Phosphodiesterase
HFP99_03300	ENOG4107ESN	Flagella basal body P-ring formation protein flgA
HFP99_03310	ENOG4105BZU	Histidine kinase
HFP99_03315	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HFP99_03320	ENOG4108ZC9	flagellar basal-body rod protein flgc
HFP99_03330	ENOG4105BZE	flagellar hook protein, FlgE
HFP99_03335	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HFP99_03340	ENOG4105CGA	flagellar basal-body rod protein FlgG
HFP99_03345	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_03350	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_03355	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HFP99_03370	ENOG4105CJW	magnesium transporter
HFP99_03375	ENOG4105C9X	ppx gppa phosphatase
HFP99_03380	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HFP99_03385	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HFP99_03400	ENOG4105BZU	Histidine kinase
HFP99_03410	ENOG4107QNR	UPF0135 protein
HFP99_03430	ENOG4105J12	Multidrug resistance protein mdtN
HFP99_03445	ENOG4105DN3	alpha-2-macroglobulin domain protein
HFP99_03450	ENOG4108JQB	penicillin-binding protein 1C
HFP99_03460	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HFP99_03470	ENOG4105EN6	Membrane
HFP99_03475	ENOG4105I03	Flagellin
HFP99_03480	ENOG4105I03	Flagellin
HFP99_03495	ENOG4105MQ3	flagellar protein FliS
HFP99_03530	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HFP99_03535	ENOG4107TY6	Acylneuraminate cytidylyltransferase
HFP99_03545	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HFP99_03550	ENOG4105C5E	polysaccharide biosynthesis protein
HFP99_03555	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HFP99_03565	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HFP99_03585	ENOG4108UYE	Lactoylglutathione lyase
HFP99_03590	ENOG4105CSM	endonuclease III
HFP99_03600	ENOG4108UQQ	Electron transport complex
HFP99_03605	ENOG4105D6A	Electron transport complex
HFP99_03615	ENOG4108R3D	Electron transport complex
HFP99_03620	ENOG4105DGN	Electron transport complex
HFP99_03635	ENOG4107SDU	Methyl-accepting chemotaxis
HFP99_03645	ENOG4105M7P	phage repressor
HFP99_03760	ENOG4108Z6H	mu-like prophage Flumu protein gp27
HFP99_03765	ENOG4105CF2	Mu-like prophage FluMu protein GP28
HFP99_03770	ENOG4105QIB	mu-like prophage Flumu protein gp29
HFP99_03790	ENOG4108TVE	i protein
HFP99_03795	ENOG4105EFV	Major head subunit
HFP99_03870	ENOG4105RKW	reductase (By
HFP99_03875	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HFP99_03880	ENOG4105CHM	Aminotransferase
HFP99_03890	ENOG41090BQ	Glutaredoxin
HFP99_03895	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HFP99_03900	ENOG4105CFI	type iii restriction protein res subunit
HFP99_03905	ENOG4105EFX	secretion protein, HlyD family
HFP99_03910	ENOG4105KK7	inner membrane protein YiaW
HFP99_03915	ENOG4105EGS	Mechanosensitive ion channel
HFP99_03925	ENOG4108NEV	two component transcriptional regulator, LytTR family
HFP99_03935	ENOG4105CPI	Metal Dependent Phosphohydrolase
HFP99_03940	ENOG4105C0A	alcohol dehydrogenase
HFP99_03945	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HFP99_03950	ENOG4107QSI	ABC, transporter
HFP99_03955	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_03960	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_03965	ENOG4105C3U	ABC transporter
HFP99_03975	ENOG4108JQ7	(ABC) transporter
HFP99_03980	ENOG4105DU1	integral membrane protein, terc
HFP99_03985	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HFP99_03995	ENOG4105CK2	sodium dicarboxylate symporter
HFP99_04010	ENOG4105CD3	dihydroorotase
HFP99_04020	ENOG4108NVR	Methyl-accepting chemotaxis
HFP99_04025	ENOG4105K59	histidine triad (HIT) protein
HFP99_04060	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_04065	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_04080	ENOG4105CKW	Inner membrane protein yedI
HFP99_04085	ENOG4105DPN	Oligoendopeptidase f
HFP99_04090	ENOG4105DPN	Oligoendopeptidase f
HFP99_04095	ENOG4105D0Y	UPF0227 protein
HFP99_04100	ENOG4105CEP	NADH dehydrogenase
HFP99_04105	ENOG4105K8R	UPF0145 protein
HFP99_04110	ENOG4107T7U	Sulfatase
HFP99_04120	ENOG4105CFH	Aspartokinase
HFP99_04125	ENOG4107QZM	n-acetylglutamate synthase
HFP99_04130	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HFP99_04170	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_04190	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_04210	ENOG4105CVN	desaturase
HFP99_04215	ENOG4107SJW	iron permease, FTR1
HFP99_04265	ENOG4105CHH	sulfate transporter
HFP99_04300	ENOG4108WC9	type VI secretion system effector, hcp1 family
HFP99_04310	ENOG4105CS6	Rhs element vgr protein
HFP99_04320	ENOG4105CNA	YD repeat protein
HFP99_04385	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_04420	ENOG4105CS6	Rhs element vgr protein
HFP99_04445	ENOG4105E3S	small subunit
HFP99_04450	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_04455	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
HFP99_04460	ENOG4105DPX	Hydrogenase, large subunit
HFP99_04465	ENOG4108USZ	hydrogenase
HFP99_04470	ENOG4108WGS	hydrogenase 2-specific chaperone
HFP99_04480	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_04485	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_04495	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_04500	ENOG4107RSS	Hydrogenase accessory protein HypB
HFP99_04505	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HFP99_04510	ENOG4105C45	hydrogenase expression formation protein (HypE)
HFP99_04515	ENOG4105CQS	hydrogenase expression formation protein HypD
HFP99_04520	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
HFP99_04530	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HFP99_04535	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HFP99_04540	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HFP99_04545	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HFP99_04555	ENOG4107RE1	Inosine-guanosine kinase
HFP99_04560	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_04575	ENOG4105BZU	Histidine kinase
HFP99_04580	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HFP99_04590	ENOG4105F3T	(LipO)protein
HFP99_04605	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HFP99_04610	ENOG4105WQI	isochorismatase
HFP99_04615	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_04620	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HFP99_04630	ENOG4105C0W	non-ribosomal peptide synthetase
HFP99_04640	ENOG4108TSE	Transferase
HFP99_04645	ENOG4105E0A	ABC, transporter
HFP99_04650	ENOG4105TVJ	transport system, permease
HFP99_04655	ENOG4105DQ5	transport system permease protein
HFP99_04660	ENOG4105D05	Receptor
HFP99_04675	ENOG4105QZU	Inner membrane protein YfeZ
HFP99_04685	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HFP99_04690	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HFP99_04695	ENOG4105BZJ	Electron transfer flavoprotein
HFP99_04700	ENOG4105C10	Electron transfer flavoprotein
HFP99_04705	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HFP99_04710	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HFP99_04715	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_04720	ENOG4105EE5	Membrane protein terC
HFP99_04730	ENOG4105MH2	YfcL protein
HFP99_04735	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_04740	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
HFP99_04745	ENOG41067MG	lrgb family
HFP99_04755	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
HFP99_04765	ENOG4105CJB	Exodeoxyribonuclease I
HFP99_04785	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HFP99_04825	ENOG4105DZR	Type I site-specific deoxyribonuclease
HFP99_04855	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HFP99_04895	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HFP99_04910	ENOG4105CHM	Aminotransferase
HFP99_04915	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_04920	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HFP99_04930	ENOG4105EF1	ribulokinase
HFP99_04935	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
HFP99_04945	ENOG4105CNN	ABC, transporter
HFP99_04955	ENOG4105YK5	50S ribosomal protein L36
HFP99_04960	ENOG4105NRA	50s ribosomal protein l31 type b
HFP99_04965	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
HFP99_04970	ENOG4105XEP	YhcH YjgK YiaL family protein
HFP99_04975	ENOG4108UHU	Aldolase
HFP99_04980	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
HFP99_04985	ENOG4105J4Q	Transcriptional regulator
HFP99_04990	ENOG4105P66	Membrane
HFP99_04995	ENOG4105CHR	reductase
HFP99_05015	ENOG4108VKG	metal-dependent hydrolase
HFP99_05030	ENOG4105CEE	C4-dicarboxylate transporter
HFP99_05040	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HFP99_05045	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_05060	ENOG4105BZN	citrate synthase
HFP99_05065	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HFP99_05070	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HFP99_05075	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HFP99_05080	ENOG4105E33	succinate dehydrogenase
HFP99_05085	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HFP99_05090	ENOG4105C7S	Dehydrogenase
HFP99_05095	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HFP99_05100	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HFP99_05115	ENOG4105CJP	fad dependent oxidoreductase
HFP99_05120	ENOG4107RCV	ABC transporter, permease
HFP99_05130	ENOG4105C4Y	ABC transporter
HFP99_05140	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HFP99_05145	ENOG4108JPW	Aminotransferase
HFP99_05150	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HFP99_05155	ENOG4105C6N	Formate acetyltransferase
HFP99_05160	ENOG4105TMB	Formate nitrite transporter
HFP99_05165	ENOG4105DDY	UPF0142 protein ycaO
HFP99_05180	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HFP99_05185	ENOG4105VEQ	Cold shock protein
HFP99_05190	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HFP99_05195	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_05200	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HFP99_05205	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HFP99_05210	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HFP99_05215	ENOG4107MBR	17 kDa surface antigen
HFP99_05220	ENOG4105BZU	Histidine kinase
HFP99_05225	ENOG4105C3M	thioredoxin reductase
HFP99_05230	ENOG4105DCF	alanine dehydrogenase
HFP99_05235	ENOG4105EW9	transcriptional regulator AsnC family
HFP99_05240	ENOG4105CNU	cell division protein FtsK
HFP99_05245	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HFP99_05250	ENOG4105D1H	recombination factor protein RarA
HFP99_05255	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HFP99_05260	ENOG4105E96	Colicin v production protein
HFP99_05265	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HFP99_05270	ENOG4105CS2	ec 3.2.1.21
HFP99_05275	ENOG4105C5Y	PTS System
HFP99_05280	ENOG4105DDV	Transcriptional regulator (LacI family
HFP99_05285	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HFP99_05290	ENOG4108JQ2	peptide transport system atp-binding protein
HFP99_05300	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HFP99_05310	ENOG4108I5W	peptide transport system, permease protein
HFP99_05315	ENOG4108J59	Extracellular solute-binding protein, family 5
HFP99_05320	ENOG4105E51	psp operon transcriptional activator
HFP99_05325	ENOG41087YS	Phage shock protein A
HFP99_05330	ENOG4105YYT	phage shock protein B
HFP99_05340	ENOG4105CM6	amino acid regulated cytosolic protein
HFP99_05345	ENOG4106K28	UPF0283 membrane protein
HFP99_05350	ENOG4105MIR	Phenylalanine 4-monooxygenase
HFP99_05355	ENOG41090A4	Pterin carbinolamine dehydratase
HFP99_05365	ENOG4108WS1	
HFP99_05370	ENOG4108KHX	Diguanylate cyclase
HFP99_05375	ENOG41090EK	ompa motb domain protein
HFP99_05380	ENOG4105D4P	Coproporphyrinogen iii oxidase
HFP99_05385	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HFP99_05400	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_05405	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HFP99_05430	ENOG4105FQ6	thiopurine methyltransferase
HFP99_05435	ENOG4107QXK	peptidase
HFP99_05440	ENOG4108BY2	phosphohistidine phosphatase
HFP99_05450	ENOG4108IPJ	Membrane
HFP99_05455	ENOG4108J59	Extracellular solute-binding protein, family 5
HFP99_05460	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HFP99_05475	ENOG4105D60	lipoprotein releasing system transmembrane protein
HFP99_05480	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_05485	ENOG4105D60	lipoprotein releasing system transmembrane protein
HFP99_05490	ENOG4105DK2	UPF0207 protein
HFP99_05500	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HFP99_05505	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HFP99_05510	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HFP99_05515	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HFP99_05520	ENOG4105K70	DNA-binding protein
HFP99_05525	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HFP99_05530	ENOG4105C5H	ABC transporter
HFP99_05535	ENOG4107QN1	sodium solute
HFP99_05540	ENOG41062QD	Membrane
HFP99_05555	ENOG41060WC	Enoyl-CoA hydratase
HFP99_05560	ENOG4105BZG	amino acid carrier protein
HFP99_05575	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HFP99_05590	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HFP99_05605	ENOG4105E39	Enoyl-CoA hydratase
HFP99_05610	ENOG4107QX3	carboxylase
HFP99_05615	ENOG4105C1G	acyl-Coa dehydrogenase
HFP99_05620	ENOG4105C26	Dehydrogenase
HFP99_05625	ENOG4105C1G	acyl-Coa dehydrogenase
HFP99_05630	ENOG4105E39	Enoyl-CoA hydratase
HFP99_05635	ENOG4105E39	Enoyl-CoA hydratase
HFP99_05640	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HFP99_05645	ENOG4105CHR	reductase
HFP99_05650	ENOG4105D5Q	Arginine ornithine antiporter
HFP99_05655	ENOG4105HF0	Membrane
HFP99_05665	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_05675	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
HFP99_05680	ENOG410642W	LysR family Transcriptional regulator
HFP99_05690	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_05695	ENOG4107QW4	alcohol dehydrogenase
HFP99_05700	ENOG4107SET	aldo keto reductase
HFP99_05715	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_05720	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HFP99_05730	ENOG4105D01	(LipO)protein
HFP99_05745	ENOG4107R9N	ABC transporter
HFP99_05750	ENOG4105C2J	ABC transporter
HFP99_05755	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
HFP99_05775	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HFP99_05780	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HFP99_05795	ENOG4105BZU	Histidine kinase
HFP99_05800	ENOG4105DND	Transcriptional regulator
HFP99_05805	ENOG4105CS2	ec 3.2.1.21
HFP99_05810	ENOG4105CHR	reductase
HFP99_05815	ENOG4105CBN	LysR family transcriptional regulator
HFP99_05830	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HFP99_05850	ENOG4105D1S	lipid A biosynthesis
HFP99_05855	ENOG4105D1S	lipid A biosynthesis
HFP99_05865	ENOG4105EUB	pirin domain protein
HFP99_05880	ENOG4105CQ2	DNA polymerase
HFP99_05910	ENOG4107QI1	Mate efflux family protein
HFP99_05915	ENOG4105W1I	UPF0253 protein
HFP99_05920	ENOG4108R6K	riboflavin synthase, subunit alpha
HFP99_05930	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_05935	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
HFP99_05940	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HFP99_05945	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HFP99_05980	ENOG4105XW2	UPF0263 protein
HFP99_05985	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HFP99_05990	ENOG4108W5H	UPF0263 protein
HFP99_05995	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HFP99_06000	ENOG4107QMS	site-determining protein
HFP99_06005	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HFP99_06010	ENOG4105VNG	YcgL domain-containing protein
HFP99_06015	ENOG4105CVE	Lytic murein transglycosylase
HFP99_06020	ENOG4105EJQ	L-serine dehydratase
HFP99_06025	ENOG4105EJQ	L-serine dehydratase
HFP99_06030	ENOG4105NBK	UPF0345 protein
HFP99_06045	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_06050	ENOG4105D58	Diguanylate phosphodiesterase
HFP99_06055	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HFP99_06060	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HFP99_06110	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HFP99_06115	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_06120	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HFP99_06130	ENOG4108VWS	Yaeq family
HFP99_06160	ENOG4105EHG	Permease protein
HFP99_06175	ENOG4107MBR	17 kDa surface antigen
HFP99_06180	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_06210	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HFP99_06215	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HFP99_06220	ENOG4105BZU	Histidine kinase
HFP99_06230	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_06235	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HFP99_06240	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HFP99_06250	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HFP99_06260	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HFP99_06270	ENOG4105DVT	helicase
HFP99_06275	ENOG41072GX	Peptidase M22 Glycoprotease
HFP99_06285	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HFP99_06290	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_06305	ENOG4105DXC	membrane
HFP99_06315	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_06320	ENOG4105WD1	Membrane
HFP99_06325	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HFP99_06330	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HFP99_06335	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HFP99_06340	ENOG4105CHJ	isochorismatase hydrolase
HFP99_06345	ENOG4105CHJ	isochorismatase hydrolase
HFP99_06355	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_06360	ENOG4105DWD	nucleoside recognition domain protein
HFP99_06365	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_06375	ENOG4105CQ7	ATP-dependent helicase
HFP99_06385	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HFP99_06390	ENOG4105C5X	domain protein
HFP99_06400	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HFP99_06405	ENOG4105FAT	Acyl-transferase
HFP99_06415	ENOG4105DR4	Methyltransferase
HFP99_06420	ENOG4108N3W	hemolysin secretion protein
HFP99_06425	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HFP99_06435	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HFP99_06440	ENOG4105D1F	ATP-binding protein
HFP99_06445	ENOG4105DBI	uridine monophosphokinase
HFP99_06450	ENOG4105DHP	deoxycytidine triphosphate deaminase
HFP99_06455	ENOG4105CJ3	phosphate transporter
HFP99_06465	ENOG41086KC	Transcriptional regulator
HFP99_06485	ENOG4108JJ6	Type I secretion system ATPase
HFP99_06510	ENOG4105C03	ribonuclease
HFP99_06515	ENOG4105EI2	Pseudouridine synthase
HFP99_06525	ENOG4108UHJ	MAF-like protein
HFP99_06535	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HFP99_06540	ENOG4105VGS	50s ribosomal protein l32
HFP99_06545	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HFP99_06550	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HFP99_06555	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HFP99_06560	ENOG4105CHR	reductase
HFP99_06565	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HFP99_06570	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_06575	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HFP99_06580	ENOG4105HHA	aminodeoxychorismate lyase
HFP99_06585	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HFP99_06590	ENOG4107QRG	dna polymerase iii
HFP99_06595	ENOG4105F8V	Hydrolase, tatD family
HFP99_06610	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HFP99_06615	ENOG4105DY2	Paraquat-inducible protein b
HFP99_06620	ENOG4105H2K	paraquat-inducible protein a
HFP99_06630	ENOG4105X2V	dna damage-inducible protein
HFP99_06640	ENOG4105DAN	ATP-dependent protease
HFP99_06645	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HFP99_06650	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
HFP99_06660	ENOG4105C5H	ABC transporter
HFP99_06670	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HFP99_06675	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HFP99_06680	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HFP99_06685	ENOG4105C7I	Dehydrogenase
HFP99_06695	ENOG4105CD8	aminopeptidase N
HFP99_06700	ENOG4105CN1	protease
HFP99_06710	ENOG4108ZGC	gaf domain protein
HFP99_06720	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HFP99_06735	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HFP99_06760	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HFP99_06765	ENOG4105Q9Y	Universal stress protein
HFP99_06770	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HFP99_06785	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_06790	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HFP99_06795	ENOG4105C2J	ABC transporter
HFP99_06800	ENOG4105CNN	ABC, transporter
HFP99_06805	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HFP99_06810	ENOG4108RVA	ribokinase
HFP99_06815	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_06820	ENOG4105BZU	Histidine kinase
HFP99_06830	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HFP99_06845	ENOG4105BZU	Histidine kinase
HFP99_06850	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HFP99_06855	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HFP99_06860	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HFP99_06865	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HFP99_06875	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HFP99_06880	ENOG4105C22	threonyL-tRNA synthetase
HFP99_06910	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_06915	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HFP99_06920	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HFP99_06925	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HFP99_06930	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HFP99_06935	ENOG4105XPH	Ferredoxin
HFP99_06940	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HFP99_06945	ENOG4105XZD	Fe-S protein
HFP99_06950	ENOG4105DM4	PTS System
HFP99_06955	ENOG4105DE4	1-phosphofructokinase
HFP99_06960	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HFP99_06965	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HFP99_06970	ENOG4105E0U	tyrosine-specific transport protein
HFP99_06985	ENOG4105WJG	Glutathione
HFP99_06990	ENOG4105C1J	atp-dependent rna helicase
HFP99_07000	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HFP99_07005	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HFP99_07010	ENOG4108DG9	Smr protein MutS2
HFP99_07045	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HFP99_07055	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HFP99_07070	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HFP99_07085	ENOG4105D9N	nucleoside
HFP99_07090	ENOG4107U5R	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HFP99_07150	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
HFP99_07155	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HFP99_07160	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HFP99_07165	ENOG4106371	Methyltransferase
HFP99_07170	ENOG4107S90	membrAne
HFP99_07180	ENOG4105CTQ	phosphohexokinase
HFP99_07190	ENOG4105CH2	amidohydrolase
HFP99_07195	ENOG4105PAD	Hydrolase
HFP99_07200	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HFP99_07265	ENOG4105VP0	transcriptional regulator, lysR family
HFP99_07270	ENOG4105EJ9	Membrane
HFP99_07275	ENOG4106IUH	DTW domain containing protein
HFP99_07285	ENOG4105CPF	Cell wall formation (By similarity)
HFP99_07300	ENOG4105C1J	atp-dependent rna helicase
HFP99_07305	ENOG4105K5X	acetyltransferase
HFP99_07315	ENOG4105KK4	UPF0060 membrane protein
HFP99_07340	ENOG41061CK	Antibiotic biosynthesis monooxygenase
HFP99_07345	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HFP99_07365	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HFP99_07375	ENOG4105WQ3	Rna-binding protein
HFP99_07390	ENOG4105BZ1	(ABC) transporter
HFP99_07395	ENOG4105BZ1	(ABC) transporter
HFP99_07400	ENOG4105BZU	Histidine kinase
HFP99_07405	ENOG4105K63	Thioredoxin
HFP99_07410	ENOG4105C8P	)-transporter
HFP99_07420	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HFP99_07440	ENOG4105CRQ	synthase (Component I)
HFP99_07445	ENOG4105P8F	nudix hydrolase
HFP99_07450	ENOG4105C44	Serine transporter
HFP99_07455	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HFP99_07460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HFP99_07465	ENOG4105CYN	Serine protein kinase
HFP99_07470	ENOG4106AKX	UPF0229 protein
HFP99_07475	ENOG4105ED1	spovr family
HFP99_07480	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HFP99_07485	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HFP99_07490	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HFP99_07495	ENOG4105DQR	SNARE associated Golgi
HFP99_07505	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HFP99_07515	ENOG4105D0C	transport protein
HFP99_07520	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_07540	ENOG4108MRH	transcriptional regulatory protein
HFP99_07545	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HFP99_07550	ENOG4105E2R	ROK family
HFP99_07555	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_07560	ENOG4105K5B	UPF0225 protein
HFP99_07565	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HFP99_07570	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HFP99_07575	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HFP99_07590	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
HFP99_07595	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_07600	ENOG4105DVI	reductase, NrfD
HFP99_07605	ENOG4105DA4	cytochrome c-type biogenesis protein
HFP99_07610	ENOG4107QX9	Thiol disulfide interChange protein
HFP99_07615	ENOG4108DMF	Cytochrome C biogenesis protein
HFP99_07625	ENOG41061WM	D-Alanyl-D-Alanine
HFP99_07635	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HFP99_07640	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HFP99_07655	ENOG4105W87	Cbs domain
HFP99_07665	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HFP99_07670	ENOG4105DZ2	Transcriptional regulator
HFP99_07680	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_07685	ENOG4106TD9	Diguanylate cyclase
HFP99_07690	ENOG4105UEI	Transcriptional Regulator AraC Family
HFP99_07700	ENOG4105CR8	Transcriptional regulator
HFP99_07705	ENOG4108RYK	Nad-dependent epimerase dehydratase
HFP99_07715	ENOG4105C28	cystathionine
HFP99_07720	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HFP99_07740	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HFP99_07750	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_07755	ENOG4105CNT	hydrolase family 2
HFP99_07760	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
HFP99_07770	ENOG4108RMJ	sensory transduction regulator
HFP99_07780	ENOG4107104	thymidine kinase
HFP99_07785	ENOG4107S6Z	Na H antiporter
HFP99_07795	ENOG4108WBT	adenosyltransferase
HFP99_07800	ENOG4105VRT	cytoplasmic protein
HFP99_07805	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HFP99_07810	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HFP99_07825	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HFP99_07830	ENOG4105CFV	Tetratricopeptide repeat protein
HFP99_07840	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HFP99_07845	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HFP99_07850	ENOG4105CAT	Cytidine monophosphate kinase
HFP99_07855	ENOG4108JEN	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HFP99_07860	ENOG4105DUM	transcriptional regulator, lysR family
HFP99_07865	ENOG4105D2S	major facilitator superfamily
HFP99_07880	ENOG4108DBC	nitroreductase
HFP99_07885	ENOG4105CFC	Transporter
HFP99_07890	ENOG4105BZU	Histidine kinase
HFP99_07900	ENOG4105CBN	LysR family transcriptional regulator
HFP99_07905	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_07930	ENOG4107RGM	aldo keto reductase
HFP99_07935	ENOG4105VFU	Rna-binding protein
HFP99_07945	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
HFP99_07955	ENOG4105HA9	of methanol dehydrogenase type
HFP99_07980	ENOG4105ER2	Ompa motb domain protein
HFP99_07985	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFP99_07990	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_07995	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_08000	ENOG4105GKE	subunit e
HFP99_08005	ENOG4107QIZ	NADH dehydrogenase
HFP99_08010	ENOG4108IEH	NADH dehydrogenase subunit g
HFP99_08015	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HFP99_08020	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_08025	ENOG4107UFS	subunit j
HFP99_08030	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_08035	ENOG4105D65	subunit l
HFP99_08040	ENOG4105C8S	subunit m
HFP99_08045	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_08050	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HFP99_08055	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_08060	ENOG4105VPD	cellular component movement
HFP99_08065	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HFP99_08070	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_08075	ENOG4105N21	Membrane
HFP99_08080	ENOG4105CUT	histidyl-tRNA synthetase
HFP99_08085	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HFP99_08090	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
HFP99_08100	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HFP99_08105	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HFP99_08120	ENOG4108ZIT	Ferredoxin, 2FE-2S
HFP99_08125	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HFP99_08130	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HFP99_08135	ENOG4108Z4V	iron-sulfur cluster assembly
HFP99_08140	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HFP99_08145	ENOG4105C3J	Cysteine desulfurase
HFP99_08150	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HFP99_08155	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HFP99_08185	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HFP99_08190	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_08195	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_08200	ENOG4105VIE	preprotein translocase, subunit YajC
HFP99_08205	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HFP99_08210	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HFP99_08215	ENOG4105W87	Cbs domain
HFP99_08220	ENOG4105D3R	alkyl hydroperoxide reductase
HFP99_08240	ENOG4105BZU	Histidine kinase
HFP99_08280	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFP99_08285	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HFP99_08290	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HFP99_08295	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HFP99_08300	ENOG4105D0A	hydroxylase
HFP99_08320	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_08325	ENOG4105C2J	ABC transporter
HFP99_08330	ENOG4105CNN	ABC, transporter
HFP99_08335	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HFP99_08350	ENOG4105E5M	Multidrug resistance protein D
HFP99_08355	ENOG4105C3U	ABC transporter
HFP99_08360	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_08365	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_08375	ENOG4105CYM	Glutathione S-transferase
HFP99_08380	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_08390	ENOG4105ECY	inositol monophosphatase
HFP99_08395	ENOG4105EIY	sodium-type flagellar protein motY
HFP99_08400	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HFP99_08405	ENOG4105D3Y	Na H antiporter
HFP99_08415	ENOG4105EQ2	LysR family Transcriptional regulator
HFP99_08420	ENOG4105C1J	atp-dependent rna helicase
HFP99_08425	ENOG4105KA0	thioesterase Superfamily protein
HFP99_08435	ENOG4105CQB	FAD linked oxidase domain protein
HFP99_08455	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_08465	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HFP99_08475	ENOG4105CAQ	asparagine synthetase
HFP99_08485	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_08495	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HFP99_08500	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HFP99_08510	ENOG4108W1A	pseudouridine synthase
HFP99_08520	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_08525	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_08550	ENOG4105D25	secreted protein
HFP99_08580	ENOG4108J8C	transporter major facilitator family protein
HFP99_08590	ENOG4105E2B	Taurine dioxygenase
HFP99_08595	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HFP99_08600	ENOG4105CR4	methylisocitrate lyase
HFP99_08605	ENOG4105BZN	citrate synthase
HFP99_08610	ENOG4108I0Z	Aconitate hydratase
HFP99_08615	ENOG4105C7F	AcnD-accessory protein PrpF
HFP99_08625	ENOG4108MN8	Membrane
HFP99_08630	ENOG4105EM2	membrane
HFP99_08635	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HFP99_08640	ENOG4108S3P	Sporulation domain protein
HFP99_08645	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HFP99_08650	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HFP99_08655	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HFP99_08665	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HFP99_08670	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HFP99_08675	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HFP99_08680	ENOG4105D01	(LipO)protein
HFP99_08695	ENOG4105DKW	ABC transporter
HFP99_08710	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HFP99_08715	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HFP99_08725	ENOG4105C85	amino acid
HFP99_08760	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
HFP99_08770	ENOG4105N5T	Radical SAM Protein
HFP99_08775	ENOG4105CBC	glutamate synthase
HFP99_08780	ENOG4105BZ8	glutamate synthase
HFP99_08795	ENOG4105C1J	atp-dependent rna helicase
HFP99_08820	ENOG4107QS8	(LipO)protein
HFP99_08825	ENOG4105BZU	Histidine kinase
HFP99_08830	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HFP99_08840	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HFP99_08845	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HFP99_08850	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HFP99_08860	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HFP99_08865	ENOG4105E66	phosphoriboisomerase A
HFP99_08870	ENOG4108JQ1	Dehydrogenase
HFP99_08875	ENOG41080IJ	Diacylglycerol kinase
HFP99_08880	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_08885	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HFP99_08890	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HFP99_08905	ENOG4105CZX	twitching motility protein
HFP99_08930	ENOG4108ZJT	translation initiation factor, Sui1
HFP99_08970	ENOG410620I	Diguanylate cyclase
HFP99_08975	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HFP99_08980	ENOG4107QKA	exodeoxyribonuclease V beta
HFP99_08990	ENOG4105C8N	cysteinyl-tRNA synthetase
HFP99_08995	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HFP99_09005	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HFP99_09010	ENOG4105Y3U	Transglycosylase-associated protein
HFP99_09015	ENOG4108TGY	Glutathione S-transferase
HFP99_09055	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HFP99_09060	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_09065	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HFP99_09070	ENOG4105W49	UPF0434 protein
HFP99_09075	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HFP99_09080	ENOG4105BZ1	(ABC) transporter
HFP99_09100	ENOG4105D7A	ATP-binding protein
HFP99_09105	ENOG4105CGF	Aromatic amino acid aminotransferase
HFP99_09120	ENOG4105DVT	helicase
HFP99_09130	ENOG4105DGU	Histone deacetylase
HFP99_09135	ENOG4108ISG	Major Facilitator
HFP99_09140	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HFP99_09145	ENOG4105G6Z	alkaline phosphatase
HFP99_09165	ENOG4105NXH	GreA GreB family elongation factor
HFP99_09170	ENOG4108KX4	response regulator
HFP99_09175	ENOG4105BZU	Histidine kinase
HFP99_09180	ENOG4105CXY	transporter
HFP99_09190	ENOG4106TNF	Periplasmic binding protein
HFP99_09195	ENOG4105E5Q	amino acid AbC transporter
HFP99_09200	ENOG4105CDA	abc transporter atp-binding protein
HFP99_09215	ENOG4105D5Q	Arginine ornithine antiporter
HFP99_09230	ENOG4105C37	(CBS) domain
HFP99_09235	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HFP99_09240	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HFP99_09245	ENOG4105E2Z	phosphate ABC transporter (Permease
HFP99_09250	ENOG4105C8U	phosphate abc transporter
HFP99_09255	ENOG4108Z6B	deaminase
HFP99_09280	ENOG4107QP3	malate synthase g
HFP99_09285	ENOG4108I9X	Isocitrate lyase
HFP99_09290	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
HFP99_09300	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HFP99_09305	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HFP99_09310	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HFP99_09320	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HFP99_09330	ENOG4105F1A	Pyruvate formate-lyase
HFP99_09340	ENOG4106YG3	ABC transporter
HFP99_09345	ENOG4105DSP	amino acid AbC transporter
HFP99_09350	ENOG4106PMH	Extracellular solute-binding protein family 3
HFP99_09355	ENOG4108JEH	abc transporter atp-binding protein
HFP99_09365	ENOG4105DYB	Isoaspartyl dipeptidase
HFP99_09370	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HFP99_09380	ENOG4105K89	arsenate reductase
HFP99_09390	ENOG4105ERG	peptidase m48, ste24p
HFP99_09395	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HFP99_09415	ENOG4105CSR	polyphosphate kinase 2
HFP99_09425	ENOG4105E89	ABC transporter
HFP99_09435	ENOG4108IJ9	(ABC) transporter
HFP99_09445	ENOG4105D56	permease protein
HFP99_09450	ENOG4107FKK	extracellular solute-binding protein family 1
HFP99_09455	ENOG4106V8H	Nucleoid-associated protein
HFP99_09460	ENOG4105PAN	UPF0352 protein
HFP99_09465	ENOG4105E68	Sulfatase
HFP99_09470	ENOG4105D05	Receptor
HFP99_09475	ENOG4105CUG	Oligopeptidase b
HFP99_09495	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
HFP99_09500	ENOG4108WFC	UPF0438 protein yifE
HFP99_09515	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_09520	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HFP99_09525	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HFP99_09530	ENOG4105E98	transcriptional regulator DeoR family
HFP99_09535	ENOG4105CXY	transporter
HFP99_09540	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HFP99_09545	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HFP99_09550	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_09575	ENOG4105CV8	reductase
HFP99_09580	ENOG4105F27	Major Facilitator
HFP99_09590	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HFP99_09595	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HFP99_09600	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HFP99_09605	ENOG4108Q2J	Inner membrane protein YebE
HFP99_09625	ENOG4106428	Protein of unknown function (DUF2496)
HFP99_09645	ENOG4105DJ2	Major Facilitator Superfamily
HFP99_09650	ENOG4105FE9	pseudouridine synthase
HFP99_09655	ENOG4105D82	Glutamate dehydrogenase
HFP99_09665	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
HFP99_09675	ENOG4108R4U	Hnh endonuclease
HFP99_09680	ENOG4105BZU	Histidine kinase
HFP99_09690	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HFP99_09695	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HFP99_09720	ENOG4108YYC	ycei family
HFP99_09725	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_09735	ENOG4105CKU	formyltetrahydrofolate synthetase
HFP99_09745	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_09750	ENOG4105EUJ	GTP cyclohydrolase i
HFP99_09755	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HFP99_09760	ENOG4105D06	uba thif-type nad fad binding protein
HFP99_09775	ENOG410832A	alpha/beta hydrolase fold
HFP99_09780	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HFP99_09785	ENOG4105E0C	molybdate abc transporter
HFP99_09790	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HFP99_09795	ENOG4108ZAF	Molybdopterin
HFP99_09800	ENOG4105M00	molybdopterin converting factor, subunit 1
HFP99_09805	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HFP99_09810	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HFP99_09815	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_09825	ENOG4105GXZ	Ferredoxin-type protein NapH
HFP99_09830	ENOG4108BGM	Quinol dehydrogenase periplasmic component
HFP99_09835	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HFP99_09850	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HFP99_09855	ENOG4105BZU	Histidine kinase
HFP99_09860	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_09875	ENOG4105BZU	Histidine kinase
HFP99_09885	ENOG4105CHW	UPF0052 protein
HFP99_09895	ENOG4105E7A	Glutamine amidotransferase
HFP99_09900	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HFP99_09905	ENOG4107QPN	acyl-Coa dehydrogenase
HFP99_09910	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_09920	ENOG4107RZZ	dna polymerase iii epsilon subunit
HFP99_09925	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HFP99_09930	ENOG4105D1A	Methyltransferase
HFP99_09935	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HFP99_09940	ENOG4105E9H	Lytic Murein transglycosylase
HFP99_09955	ENOG4105NAU	thioesterase Superfamily protein
HFP99_09965	ENOG41060NJ	transcriptional regulator
HFP99_09970	ENOG4107SC1	transglycosylase
HFP99_09975	ENOG4105BZU	Histidine kinase
HFP99_09980	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HFP99_10005	ENOG4105CFU	surface antigen
HFP99_10015	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HFP99_10025	ENOG4107ZN8	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HFP99_10035	ENOG4105VNH	ABC transporter solute-binding protein
HFP99_10045	ENOG4108VGW	abc transporter atp-binding protein
HFP99_10050	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HFP99_10055	ENOG4105CVE	Lytic murein transglycosylase
HFP99_10070	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HFP99_10075	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HFP99_10080	ENOG4105EV9	Alpha Beta Hydrolase
HFP99_10090	ENOG4105NNH	LexA regulated protein
HFP99_10095	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HFP99_10105	ENOG41090R7	Ferric uptake
HFP99_10110	ENOG4105CX6	glutaminyL-tRNA synthetase
HFP99_10120	ENOG4105C7W	Xanthine dehydrogenase
HFP99_10125	ENOG4108XHQ	(2Fe-2S)-binding domain protein
HFP99_10130	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HFP99_10150	ENOG4108JJA	ABC, transporter
HFP99_10175	ENOG4107R0E	Glycosyl transferase, family 2
HFP99_10205	ENOG4105E2D	ec 3.2.1.52
HFP99_10210	ENOG4105CI1	PTS System
HFP99_10215	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HFP99_10220	ENOG4105CE4	GlcNAc 6-P deacetylase
HFP99_10225	ENOG4105E2R	ROK family
HFP99_10230	ENOG4105DIJ	Phosphoethanolamine transferase
HFP99_10235	ENOG4105CDY	transcriptional regulatory protein
HFP99_10240	ENOG4105C9M	aspartyl-trna synthetase
HFP99_10250	ENOG41081XQ	Conserved Protein
HFP99_10255	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HFP99_10260	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HFP99_10280	ENOG4105C5Q	Transcriptional regulator
HFP99_10285	ENOG4107TT5	NLP P60 protein
HFP99_10295	ENOG4107RGH	Aldehyde dehydrogenase
HFP99_10300	ENOG4107Z3H	Transcriptional regulator, TetR family
HFP99_10315	ENOG4105C6T	cysteine synthase
HFP99_10335	ENOG4105UQX	Mate efflux family protein
HFP99_10345	ENOG4105Z2P	Protein of unknown function (DUF465)
HFP99_10350	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HFP99_10360	ENOG4105QVC	MOSC domain-containing protein
HFP99_10360	ENOG4105QVC	MOSC domain-containing protein
HFP99_10365	ENOG4105D0M	Protease HtpX homolog
HFP99_10370	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HFP99_10375	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HFP99_10380	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HFP99_10385	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HFP99_10390	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HFP99_10405	ENOG4105C5S	asparaginyl-tRNA synthetase
HFP99_10410	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HFP99_10425	ENOG4105CEE	C4-dicarboxylate transporter
HFP99_10435	ENOG4105KUZ	arsenate reductase
HFP99_10440	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HFP99_10455	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HFP99_10465	ENOG410829K	Lysine exporter protein (Lyse ygga)
HFP99_10475	ENOG4105RX8	Protein of unknown function (DUF1523)
HFP99_10490	ENOG4105DU0	nucleoside hydrolase
HFP99_10495	ENOG4105D3G	Pseudouridine synthase
HFP99_10500	ENOG4107SXA	Phosphorylase
HFP99_10505	ENOG4105C0A	alcohol dehydrogenase
HFP99_10510	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_10515	ENOG4105K4T	epimerase
HFP99_10520	ENOG4105VDB	UPF0125 protein
HFP99_10525	ENOG4108Z1B	Cyclase dehydrase
HFP99_10530	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HFP99_10540	ENOG4105DFP	Integrase
HFP99_10580	ENOG4105CVR	type I restriction-modification system
HFP99_10595	ENOG4108YYD	acetyltransferase
HFP99_10620	ENOG4107R11	Transcriptional regulator
HFP99_10625	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HFP99_10645	ENOG4105M2J	Glutaredoxin
HFP99_10650	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HFP99_10655	ENOG410903C	(LipO)protein
HFP99_10665	ENOG4105KWW	Biogenesis protein
HFP99_10670	ENOG4107QX9	Thiol disulfide interChange protein
HFP99_10675	ENOG4105DA4	cytochrome c-type biogenesis protein
HFP99_10680	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HFP99_10685	ENOG4105X3C	heme exporter protein
HFP99_10690	ENOG41060IM	Heme exporter protein
HFP99_10695	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HFP99_10710	ENOG4108V3W	Chemotaxis protein, CheW
HFP99_10720	ENOG4107QJE	Chromosome Partitioning Protein
HFP99_10725	ENOG4108SEK	ompa motb domain protein
HFP99_10730	ENOG4105E14	MotA TolQ exbB proton channel
HFP99_10735	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HFP99_10750	ENOG4108VYJ	response regulator receiver protein
HFP99_10755	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_10765	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HFP99_10770	ENOG4105D7B	Flagellar biosynthesis protein flha
HFP99_10775	ENOG4105D00	flagellar biosynthetic protein flhB
HFP99_10780	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HFP99_10785	ENOG4105VS8	Flagellar biosynthetic protein fliq
HFP99_10790	ENOG4105CN7	Flagellar biosynthetic protein FliP
HFP99_10795	ENOG4105VTB	flagellar biosynthesis protein fliO
HFP99_10800	ENOG4105DD5	Flagellar motor switch protein
HFP99_10805	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_10825	ENOG4108JIR	Flagellum-specific ATP synthase
HFP99_10835	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_10840	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HFP99_10845	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HFP99_10860	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HFP99_10885	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_10895	ENOG4108JQ7	(ABC) transporter
HFP99_10905	ENOG4105RD7	BadF BadG BcrA BcrD
HFP99_10910	ENOG4105E2D	ec 3.2.1.52
HFP99_10915	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_10930	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HFP99_10935	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
HFP99_10940	ENOG4105ERU	peptidase
HFP99_10945	ENOG4105UBK	short-chain dehydrogenase reductase
HFP99_10950	ENOG4105C5Q	Transcriptional regulator
HFP99_10960	ENOG4105C87	Aminotransferase class I and II
HFP99_10975	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HFP99_11005	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HFP99_11010	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_11030	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_11035	ENOG4105NQG	DoxX
HFP99_11045	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_11060	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HFP99_11065	ENOG4107TT5	NLP P60 protein
HFP99_11070	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
HFP99_11075	ENOG4107QR8	Thioredoxin
HFP99_11085	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HFP99_11090	ENOG4105CIY	formyltetrahydrofolate deformylase
HFP99_11115	ENOG4105E4C	Lytic transglycosylase catalytic
HFP99_11125	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HFP99_11130	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HFP99_11135	ENOG4105EP9	oxidoreductase
HFP99_11160	ENOG4108UK5	Transposase
HFP99_11170	ENOG4105CCT	upf0313 protein
HFP99_11180	ENOG4105BZS	acriflavin resistance protein
HFP99_11190	ENOG4106TD9	Diguanylate cyclase
HFP99_11195	ENOG4105D78	K07001 NTE family protein
HFP99_11200	ENOG4105C8J	)-transporter
HFP99_11215	ENOG4105UYK	outer membrane protein a
HFP99_11220	ENOG4105UYK	outer membrane protein a
HFP99_11225	ENOG4105UYK	outer membrane protein a
HFP99_11230	ENOG4107R1I	NAD-dependent malic enzyme
HFP99_11235	ENOG41075H3	AraC family transcriptional regulator
HFP99_11240	ENOG4105UQX	Mate efflux family protein
HFP99_11245	ENOG4105RKX	Protein of unknown function (DUF2498)
HFP99_11255	ENOG4105C2W	permease
HFP99_11260	ENOG4108KMH	lipoate-protein ligase a
HFP99_11265	ENOG4105BZG	amino acid carrier protein
HFP99_11285	ENOG4105PTV	Nudix Hydrolase
HFP99_11295	ENOG4105CDA	abc transporter atp-binding protein
HFP99_11300	ENOG4105DRP	amino acid AbC transporter
HFP99_11305	ENOG4105EZ7	amino acid ABC transporter
HFP99_11325	ENOG4105CJ1	ABC, transporter
HFP99_11330	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_11335	ENOG4106N3A	copper homeostasis protein cutc
HFP99_11350	ENOG4105ERG	peptidase m48, ste24p
HFP99_11355	ENOG4105DJH	phosphate
HFP99_11360	ENOG4105BZU	Histidine kinase
HFP99_11365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HFP99_11370	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HFP99_11375	ENOG4105BZU	Histidine kinase
HFP99_11385	ENOG4105C26	Dehydrogenase
HFP99_11395	ENOG4108IPJ	Membrane
HFP99_11400	ENOG4106YYS	transcriptional regulatory protein
HFP99_11410	ENOG4107R1I	NAD-dependent malic enzyme
HFP99_11415	ENOG4105D2K	citrate carrier protein
HFP99_11420	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
HFP99_11425	ENOG4105J12	Multidrug resistance protein mdtN
HFP99_11455	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HFP99_11460	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HFP99_11470	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HFP99_11480	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HFP99_11485	ENOG4105EXN	Sulfate transport protein CysZ
HFP99_11490	ENOG4105EN6	Membrane
HFP99_11500	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HFP99_11505	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HFP99_11535	ENOG4107T9C	Alpha amylase catalytic region
HFP99_11570	ENOG4105BZU	Histidine kinase
HFP99_11575	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HFP99_11580	ENOG4105C9K	Endothelin-converting enzyme 1
HFP99_11590	ENOG4105C5H	ABC transporter
HFP99_11600	ENOG4105DVH	amino acid
HFP99_11605	ENOG4105C44	Serine transporter
HFP99_11610	ENOG410642W	LysR family Transcriptional regulator
HFP99_11640	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HFP99_11645	ENOG4105C0B	DNA polymerase III (alpha subunit)
HFP99_11650	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HFP99_11655	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_11660	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_11665	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HFP99_11670	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_11675	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HFP99_11685	ENOG4105DZP	Membrane-associated zinc metalloprotease
HFP99_11690	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HFP99_11695	ENOG4105KNE	Phosphatidate cytidylyltransferase
HFP99_11705	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HFP99_11710	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HFP99_11715	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HFP99_11720	ENOG4105CE9	30S ribosomal protein S2
HFP99_11725	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HFP99_11730	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HFP99_11735	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HFP99_11740	ENOG4108T8E	UPF0325 protein
HFP99_11745	ENOG4105CI1	PTS System
HFP99_11750	ENOG4107W52	maltose operon periplasmic protein
HFP99_11755	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HFP99_11760	ENOG4105QDK	Flavodoxin
HFP99_11765	ENOG4105DR9	pseudouridine synthase
HFP99_11770	ENOG4105WP7	tRNA pseudouridine synthase C
HFP99_11795	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HFP99_11800	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HFP99_11805	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HFP99_11820	ENOG4105EWT	decarboxylase family
HFP99_11825	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HFP99_11830	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HFP99_11840	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HFP99_11845	ENOG4105M08	Membrane
HFP99_11855	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_11860	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_11865	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HFP99_11880	ENOG4105CJ2	(LipO)protein
HFP99_11885	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HFP99_11890	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_11895	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_11900	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_11905	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_11910	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_11915	ENOG4105M85	Bola protein
HFP99_11930	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HFP99_11940	ENOG4105EYM	Major Facilitator superfamily
HFP99_11950	ENOG4108VPT	UPF0234 protein
HFP99_11955	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HFP99_11960	ENOG4107S0N	DJ-1 family
HFP99_11985	ENOG4105CS6	Rhs element vgr protein
HFP99_11990	ENOG4108WC9	type VI secretion system effector, hcp1 family
HFP99_11995	ENOG4105VJY	transcriptional regulator
HFP99_12000	ENOG4105CHH	sulfate transporter
HFP99_12005	ENOG4105K89	arsenate reductase
HFP99_12010	ENOG4105D6J	arsenicaL-resistance protein
HFP99_12060	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HFP99_12065	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HFP99_12070	ENOG4105BZS	acriflavin resistance protein
HFP99_12090	ENOG4105CMR	udp-glucose 4-epimerase
HFP99_12095	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HFP99_12100	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
HFP99_12105	ENOG4108RMU	ferritin dps family protein
HFP99_12130	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HFP99_12145	ENOG4107FW0	short-chain dehydrogenase reductase
HFP99_12155	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HFP99_12160	ENOG4108XDN	Transcriptional regulator
HFP99_12165	ENOG4107SEY	Conserved Protein
HFP99_12190	ENOG4105CQC	Prephenate dehydratase
HFP99_12230	ENOG4107RDJ	Sulfotransferase
HFP99_12255	ENOG4105D8V	Glucose sorbosone dehydrogenase
HFP99_12265	ENOG4105MVE	transcriptional regulator
HFP99_12275	ENOG4105G63	Type III effector Hrp-dependent
HFP99_12280	ENOG4105FB2	class II Aldolase
HFP99_12285	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HFP99_12290	ENOG4105EXW	epimerase dehydratase
HFP99_12295	ENOG4105C6Z	Gluconate
HFP99_12305	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_12315	ENOG4105E1F	short-chain dehydrogenase reductase
HFP99_12340	ENOG4105CTD	carboxy-peptidase
HFP99_12360	ENOG4105XDF	Protein of unknown function (DUF1272)
HFP99_12370	ENOG4105CFP	Peptidase U32
HFP99_12375	ENOG4105N14	lysine exporter protein LysE YggA
HFP99_12385	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HFP99_12410	ENOG4105BZU	Histidine kinase
HFP99_12415	ENOG41068CG	regulatoR
HFP99_12440	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
HFP99_12450	ENOG4105DB1	molybdopterin oxidoreductase
HFP99_12455	ENOG4106WHD	Tetrathionate reductase
HFP99_12460	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_12465	ENOG4105BZU	Histidine kinase
HFP99_12470	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HFP99_12475	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
HFP99_12480	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HFP99_12485	ENOG4105CW7	secretion protein, HlyD family
HFP99_12505	ENOG4105C26	Dehydrogenase
HFP99_12510	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HFP99_12515	ENOG4105CDU	Replicative dna helicase
HFP99_12525	ENOG4105CGH	5'-nucleotidase
HFP99_12550	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_12565	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HFP99_12570	ENOG4105VKU	nucleicacid-binding protein
HFP99_12585	ENOG4105DNZ	Alpha Beta Hydrolase
HFP99_12595	ENOG4105YP7	UPF0270 protein
HFP99_12600	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HFP99_12615	ENOG4108UKZ	OsmC family
HFP99_12620	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HFP99_12635	ENOG4105BZU	Histidine kinase
HFP99_12640	ENOG4105D8G	Major Facilitator superfamily
HFP99_12665	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HFP99_12670	ENOG41090JE	Utilization Protein
HFP99_12680	ENOG4105EHG	Permease protein
HFP99_12695	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HFP99_12705	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HFP99_12715	ENOG4105CKK	Glycosyl transferase, family 2
HFP99_12720	ENOG4105E4C	Lytic transglycosylase catalytic
HFP99_12725	ENOG4105C5H	ABC transporter
HFP99_12735	ENOG4105C7N	Xanthine uracil vitamin C permease
HFP99_12740	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HFP99_12745	ENOG4108S0S	Nucleotidyl transferase
HFP99_12750	ENOG4105EHM	Aminoglycoside phosphotransferase
HFP99_12755	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HFP99_12765	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HFP99_12770	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HFP99_12780	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HFP99_12790	ENOG4105DEN	Luciferase family
HFP99_12795	ENOG4105DHT	Metal Dependent Phosphohydrolase
HFP99_12800	ENOG4105DWD	nucleoside recognition domain protein
HFP99_12805	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFP99_12810	ENOG4105K46	50S ribosomal protein l27
HFP99_12815	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HFP99_12820	ENOG4105EAH	synthase
HFP99_12830	ENOG4105EPW	hflc protein
HFP99_12835	ENOG4107QJR	hflk protein
HFP99_12840	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HFP99_12845	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HFP99_12850	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HFP99_12855	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HFP99_12860	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HFP99_12865	ENOG4105K8N	protein family UPF0079, ATPase
HFP99_12870	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HFP99_12890	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_12895	ENOG4108UMI	ABC transporter, permease
HFP99_12900	ENOG4105D01	(LipO)protein
HFP99_12905	ENOG4105MDZ	Transcriptional activator rfaH
HFP99_12910	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_12915	ENOG4105BZU	Histidine kinase
HFP99_12930	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HFP99_12935	ENOG4105BZU	Histidine kinase
HFP99_12960	ENOG4105EXG	Transcriptional regulator
HFP99_12970	ENOG4107QWK	SAICAR synthetase
HFP99_12975	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_12980	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HFP99_12985	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HFP99_12990	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_13000	ENOG4105XWI	UPF0304 protein
HFP99_13010	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HFP99_13015	ENOG4105C6K	Malic enzyme
HFP99_13020	ENOG4108ZP8	Acetolactate synthase small subunit
HFP99_13025	ENOG4105C7K	acetolactate synthase
HFP99_13035	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HFP99_13040	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HFP99_13050	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HFP99_13060	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HFP99_13065	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HFP99_13080	ENOG4105DP9	ABC transporter
HFP99_13085	ENOG4106SMU	thiamine transporter membrane protein
HFP99_13090	ENOG4107T0D	ABC, transporter
HFP99_13095	ENOG4108IAB	Phoh family
HFP99_13135	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HFP99_13145	ENOG4105CMQ	Chloride channel
HFP99_13150	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HFP99_13165	ENOG41076MN	Phosphoesterase, PA-phosphatase related
HFP99_13180	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
HFP99_13185	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
HFP99_13190	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HFP99_13195	ENOG4105BZ4	penicillin-binding protein
HFP99_13200	ENOG4105CQ7	ATP-dependent helicase
HFP99_13210	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HFP99_13220	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HFP99_13225	ENOG4105DJ0	Poly(A) Polymerase
HFP99_13230	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFP99_13235	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HFP99_13240	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HFP99_13250	ENOG4105E3A	(ABC) transporter
HFP99_13255	ENOG4105DA5	(ABC) transporter
HFP99_13260	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HFP99_13265	ENOG410630P	Transcriptional regulator
HFP99_13270	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HFP99_13275	ENOG4105DFU	Cell wall formation (By similarity)
HFP99_13280	ENOG4105F0N	pyrophosphate phospho-hydrolase
HFP99_13295	ENOG4108UUE	Transcriptional regulator
HFP99_13310	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_13340	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HFP99_13350	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HFP99_13355	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HFP99_13360	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HFP99_13365	ENOG4107QX8	SPFH domain, Band 7 family protein
HFP99_13370	ENOG4105G5H	Membrane
HFP99_13380	ENOG4105D9R	oxidoreductase
HFP99_13390	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HFP99_13395	ENOG4105CSA	Coproporphyrinogen iii oxidase
HFP99_13400	ENOG4105VCN	Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system
HFP99_13415	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HFP99_13420	ENOG4105C12	Phosphoribosylglycinamide synthetase
HFP99_13450	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_13455	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HFP99_13460	ENOG4105KTH	gatB Yqey
HFP99_13465	ENOG4105VCC	30S ribosomal protein S21
HFP99_13470	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HFP99_13480	ENOG4108K5P	(LipO)protein
HFP99_13490	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HFP99_13495	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HFP99_13500	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HFP99_13505	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HFP99_13510	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HFP99_13515	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HFP99_13520	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HFP99_13525	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HFP99_13530	ENOG4105DXN	mazG family
HFP99_13535	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HFP99_13540	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HFP99_13545	ENOG4105BZU	Histidine kinase
HFP99_13550	ENOG4108W15	Protein of unknown function (DUF1456)
HFP99_13555	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HFP99_13560	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HFP99_13565	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HFP99_13580	ENOG4105C3F	Signal peptidase i
HFP99_13585	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HFP99_13605	ENOG4105EMN	RNA polymerase sigma factor
HFP99_13610	ENOG4108IYU	L-aspartate oxidase
HFP99_13650	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HFP99_13660	ENOG4105CJP	fad dependent oxidoreductase
HFP99_13665	ENOG4105D2N	Aldolase
HFP99_13670	ENOG4105BZA	Phosphoglycerate kinase
HFP99_13675	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HFP99_13680	ENOG4105DKQ	ROK family
HFP99_13685	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HFP99_13695	ENOG4106MWK	domain protein
HFP99_13700	ENOG4105EYW	Ion transport protein
HFP99_13705	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_13715	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HFP99_13725	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HFP99_13740	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HFP99_13745	ENOG4105DRP	amino acid AbC transporter
HFP99_13750	ENOG4105E5Q	amino acid AbC transporter
HFP99_13760	ENOG4105CT1	(ABC) transporter
HFP99_13765	ENOG4107PU6	Membrane
HFP99_13770	ENOG4108UW5	maltose o-acetyltransferase
HFP99_13795	ENOG41090U3	tautomerase
HFP99_13805	ENOG4107NQ8	LysR family Transcriptional regulator
HFP99_13810	ENOG4105CH7	arginosuccinase
HFP99_13815	ENOG4105CDH	Citrulline--aspartate ligase
HFP99_13825	ENOG4105CAS	nag kinase
HFP99_13830	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HFP99_13840	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HFP99_13845	ENOG4105BZU	Histidine kinase
HFP99_13850	ENOG4108Z66	YbaK ebsC protein
HFP99_13880	ENOG4105CMU	LysR family (Transcriptional regulator
HFP99_13890	ENOG41067MG	lrgb family
HFP99_13895	ENOG4105CFH	Aspartokinase
HFP99_13900	ENOG4105C28	cystathionine
HFP99_13905	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HFP99_13915	ENOG4108Z7R	Chaperone CsaA
HFP99_13920	ENOG4105C44	Serine transporter
HFP99_13925	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HFP99_13930	ENOG4107RK2	ADP-ribose diphosphatase NudE
HFP99_13935	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_13940	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HFP99_13945	ENOG4108UDW	Transcriptional regulator, luxr family
HFP99_13955	ENOG4105F8D	glycoside hydrolase family 4
HFP99_13960	ENOG4105EZV	Transcriptional regulator
HFP99_13965	ENOG4105VCP	PTS System
HFP99_13970	ENOG4105CS2	ec 3.2.1.21
HFP99_13975	ENOG4105CK1	PTS System
HFP99_13980	ENOG4105VZJ	PTS System
HFP99_14025	ENOG4108VAU	general secretion pathway protein G
HFP99_14030	ENOG4105D7Q	type ii secretion system
HFP99_14035	ENOG4107QHF	type ii secretion system protein e
HFP99_14050	ENOG4105VEJ	Heat shock protein
HFP99_14055	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HFP99_14060	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HFP99_14080	ENOG4108XTF	Outer Membrane Lipoprotein
HFP99_14085	ENOG4105I7R	Adenylate cyclase
HFP99_14090	ENOG4107IX6	phosphate transport regulator
HFP99_14095	ENOG4105CJ3	phosphate transporter
HFP99_14100	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HFP99_14120	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HFP99_14125	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HFP99_14145	ENOG4108Q2G	(LipO)protein
HFP99_14150	ENOG4105DY2	Paraquat-inducible protein b
HFP99_14155	ENOG4105F1S	paraquat-inducible protein a
HFP99_14160	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HFP99_14165	ENOG4107VXZ	Hydrolase
HFP99_14175	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HFP99_14180	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HFP99_14185	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HFP99_14190	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HFP99_14230	ENOG4105DFD	Na H antiporter
HFP99_14235	ENOG4108M0I	Transcriptional regulator
HFP99_14240	ENOG4107TYH	extracellular solute-binding protein family 1
HFP99_14245	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_14250	ENOG4105D81	ABC transporter, permease
HFP99_14255	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
HFP99_14260	ENOG4105C26	Dehydrogenase
HFP99_14265	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HFP99_14270	ENOG4107VFP	cytochrome oxidase assembly
HFP99_14290	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HFP99_14295	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HFP99_14310	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HFP99_14325	ENOG4108UQY	Iron-storage protein
HFP99_14330	ENOG4108Z5K	methylglyoxal synthase
HFP99_14345	ENOG4105HDK	L-asparaginase
HFP99_14355	ENOG4105DDV	Transcriptional regulator (LacI family
HFP99_14365	ENOG4105DKQ	ROK family
HFP99_14370	ENOG4105VCP	PTS System
HFP99_14375	ENOG4105CS2	ec 3.2.1.21
HFP99_14380	ENOG4105CK1	PTS System
HFP99_14385	ENOG4105VZJ	PTS System
HFP99_14390	ENOG4105CK1	PTS System
HFP99_14405	ENOG4105D4X	repressor
HFP99_14410	ENOG4105C5Y	PTS System
HFP99_14415	ENOG4105CG3	alpha amylase, catalytic region
HFP99_14420	ENOG4108UW5	maltose o-acetyltransferase
HFP99_14430	ENOG4107AQZ	Membrane
HFP99_14450	ENOG4105UYK	outer membrane protein a
HFP99_14475	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HFP99_14480	ENOG4107ZVW	dihydroneopterin aldolase
HFP99_14485	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFP99_14495	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HFP99_14500	ENOG4105CKI	cobalamin synthesis protein
HFP99_14510	ENOG4105E82	cytochrome subunit of dehydrogenase
HFP99_14520	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_14525	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HFP99_14530	ENOG4105BZU	Histidine kinase
HFP99_14535	ENOG4105BZU	Histidine kinase
HFP99_14540	ENOG4107QIJ	Aconitate hydratase 2
HFP99_14550	ENOG41069D7	Methyl-accepting chemotaxis
HFP99_14555	ENOG4108N3W	hemolysin secretion protein
HFP99_14570	ENOG4107QN2	dihydrolipoyl dehydrogenase
HFP99_14575	ENOG4107QSN	dihydrolipoamide acetyltransferase
HFP99_14580	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HFP99_14585	ENOG41073TP	transcriptional regulator
HFP99_14600	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HFP99_14610	ENOG4107QHF	type ii secretion system protein e
HFP99_14615	ENOG4105D7Q	type ii secretion system
HFP99_14630	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HFP99_14635	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HFP99_14640	ENOG4105M6F	mutator MutT protein
HFP99_14645	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HFP99_14655	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_14660	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HFP99_14665	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HFP99_14670	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HFP99_14675	ENOG4105DFU	Cell wall formation (By similarity)
HFP99_14680	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HFP99_14685	ENOG4105CNI	cell division protein FtsW
HFP99_14690	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HFP99_14695	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HFP99_14700	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HFP99_14705	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HFP99_14710	ENOG4105CJN	penicillin-binding protein
HFP99_14715	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HFP99_14720	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HFP99_14725	ENOG4108V6E	Cell division protein mraZ
HFP99_14735	ENOG4105E9H	Lytic Murein transglycosylase
HFP99_14745	ENOG4105ER2	Ompa motb domain protein
HFP99_14750	ENOG4107RD7	Flagellar Motor Protein, MotA
HFP99_14775	ENOG4105MQ3	flagellar protein FliS
HFP99_14780	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
HFP99_14785	ENOG4105I03	Flagellin
HFP99_14790	ENOG4105I03	Flagellin
HFP99_14795	ENOG4108C80	FliB family
HFP99_14805	ENOG4105DTJ	flagellar hook-associated protein
HFP99_14810	ENOG4105E1Q	flagellar hook-associated protein
HFP99_14820	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_14825	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_14830	ENOG4105CGA	flagellar basal-body rod protein FlgG
HFP99_14835	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HFP99_14840	ENOG4105BZE	flagellar hook protein, FlgE
HFP99_14845	ENOG4105W00	Flagellar hook capping protein
HFP99_14850	ENOG4108ZC9	flagellar basal-body rod protein flgc
HFP99_14855	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HFP99_14865	ENOG4105M9M	anti-sigma28 factor FlgM
HFP99_14880	ENOG4108JIR	Flagellum-specific ATP synthase
HFP99_14890	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_14895	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HFP99_14900	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HFP99_14915	ENOG4105D00	flagellar biosynthetic protein flhB
HFP99_14920	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HFP99_14925	ENOG4105VS8	Flagellar biosynthetic protein fliq
HFP99_14930	ENOG4105CN7	Flagellar biosynthetic protein FliP
HFP99_14935	ENOG4105DD5	Flagellar motor switch protein
HFP99_14950	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HFP99_14955	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HFP99_14960	ENOG41082RQ	UPF0102 protein
HFP99_14965	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HFP99_14970	ENOG4105W4M	Transport-associated protein
HFP99_14975	ENOG4105KB2	stringent starvation protein b
HFP99_14980	ENOG4107MKT	Stringent starvation protein a
HFP99_14985	ENOG4105EIX	cytochrome c1
HFP99_14990	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HFP99_14995	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HFP99_15000	ENOG4108UJD	30S ribosomal protein S9
HFP99_15005	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HFP99_15010	ENOG4105D6Z	AFG1 family ATPase
HFP99_15020	ENOG4105C0H	protease
HFP99_15025	ENOG4105C0H	protease
HFP99_15055	ENOG41069H0	dihydroorotase EC 3.5.2.3
HFP99_15075	ENOG41080Z8	PHOSPHOCARRIER protein
HFP99_15080	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HFP99_15085	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HFP99_15090	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HFP99_15095	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_15100	ENOG4108IUZ	ABC transporter
HFP99_15105	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HFP99_15110	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
HFP99_15120	ENOG4105C2X	Arabinose 5-phosphate isomerase
HFP99_15125	ENOG4105DHJ	ABC, transporter
HFP99_15130	ENOG4105CY3	ABC transporter, permease
HFP99_15135	ENOG4107PE3	Mammalian cell entry related domain protein
HFP99_15140	ENOG4105E3I	toluene tolerance
HFP99_15150	ENOG4105VFK	BolA family
HFP99_15155	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HFP99_15165	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HFP99_15170	ENOG4105N42	UPF0307 protein
HFP99_15180	ENOG41090HJ	UPF0265 protein
HFP99_15210	ENOG4108JCI	Transcriptional regulator
HFP99_15215	ENOG4105DKK	Benzoate
HFP99_15225	ENOG4105SYT	Methylenetetrahydrofolate reductase
HFP99_15245	ENOG4105EIF	outer membrane protein W
HFP99_15250	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HFP99_15255	ENOG41086KC	Transcriptional regulator
HFP99_15260	ENOG4108UUM	single-stranded DNA-binding protein
HFP99_15275	ENOG4105VEQ	Cold shock protein
HFP99_15280	ENOG4105D05	Receptor
HFP99_15285	ENOG4105E0F	Histidine kinase
HFP99_15300	ENOG4108NVR	Methyl-accepting chemotaxis
HFP99_15310	ENOG4105BZU	Histidine kinase
HFP99_15315	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_15330	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
HFP99_15340	ENOG4107QYX	exodeoxyribonuclease v alpha
HFP99_15345	ENOG4107QKA	exodeoxyribonuclease V beta
HFP99_15355	ENOG4108VBZ	doxx family
HFP99_15360	ENOG4105C2I	pirin domain protein
HFP99_15370	ENOG4105CWB	LysR family transcriptional Regulator
HFP99_15405	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_15415	ENOG4105BZU	Histidine kinase
HFP99_15430	ENOG4105CF7	AraC family transcriptional regulator
HFP99_15435	ENOG4105WCN	acetyltransferase
HFP99_15440	ENOG4105CH6	catalase
HFP99_15460	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HFP99_15465	ENOG4105IPI	Membrane
HFP99_15475	ENOG4105DWY	Agmatine deiminase
HFP99_15485	ENOG4105DWY	Agmatine deiminase
HFP99_15490	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_15495	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HFP99_15500	ENOG4105VDH	Dihydroxyacetone kinase
HFP99_15505	ENOG4108UTZ	Dihydroxyacetone kinase
HFP99_15510	ENOG4105CMT	Dihydroxyacetone kinase
HFP99_15515	ENOG4105C7N	Xanthine uracil vitamin C permease
HFP99_15520	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HFP99_15550	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HFP99_15555	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HFP99_15560	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HFP99_15565	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HFP99_15570	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HFP99_15575	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HFP99_15590	ENOG4105KME	endoribonuclease L-psp
HFP99_15605	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_15610	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_15615	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HFP99_15620	ENOG4108VZM	50s ribosomal protein L10
HFP99_15625	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HFP99_15630	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HFP99_15635	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HFP99_15640	ENOG4105PM1	preprotein translocase subunit SecE
HFP99_15650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HFP99_15665	ENOG4105CS9	pantothenic acid kinase
HFP99_15670	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HFP99_15675	ENOG4105D4A	Cell wall formation (By similarity)
HFP99_15680	ENOG4107ZYR	domain protein
HFP99_15690	ENOG4108IYH	Dna topoisomerase
HFP99_15695	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_15700	ENOG4107QY8	reductase
HFP99_15710	ENOG4105IFJ	Histidine kinase
HFP99_15715	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HFP99_15735	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HFP99_15740	ENOG4108UQ5	membrane protein YcdZ
HFP99_15745	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HFP99_15755	ENOG4107WP9	Histidine kinase
HFP99_15775	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_15790	ENOG4108VVK	transcriptional Regulator, AsnC
HFP99_15795	ENOG4105CU9	asparagine synthetase A
HFP99_15800	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HFP99_15805	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_15810	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HFP99_15815	ENOG4105C34	Pseudouridine synthase
HFP99_15820	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_15830	ENOG4107R6U	sodium dicarboxylate symporter
HFP99_15835	ENOG4105CEM	UPF0597 protein
HFP99_15840	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HFP99_15845	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HFP99_15855	ENOG4105CF7	AraC family transcriptional regulator
HFP99_15860	ENOG4105QNF	Outer membrane lipoprotein
HFP99_15865	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_15880	ENOG4105CXT	aspartate transcarbamylase
HFP99_15885	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
HFP99_15890	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HFP99_15895	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HFP99_15900	ENOG4105DBV	ornithine carbamoyltransferase
HFP99_15905	ENOG4105C5B	carbamate kinase
HFP99_15925	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_15930	ENOG4108HWV	)-transporter
HFP99_15945	ENOG4105CNT	hydrolase family 2
HFP99_15950	ENOG41060NJ	transcriptional regulator
HFP99_15955	ENOG4105CMR	udp-glucose 4-epimerase
HFP99_15960	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HFP99_15965	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HFP99_15970	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HFP99_15975	ENOG4105CPC	Aldo Keto reductase
HFP99_15980	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HFP99_15985	ENOG4108NIX	Factor ChrR
HFP99_15990	ENOG4105K6V	RNA polymerase
HFP99_16000	ENOG4105C75	arginyL-tRNA synthetase
HFP99_16010	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HFP99_16015	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HFP99_16020	ENOG4105C57	major facilitator superfamily
HFP99_16035	ENOG4105D0S	secretion protein (HlyD
HFP99_16040	ENOG4105CJ1	ABC, transporter
HFP99_16045	ENOG4107QWP	ABC-2 type transporter
HFP99_16050	ENOG4107QWP	ABC-2 type transporter
HFP99_16055	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_16060	ENOG4105WZK	nitrite reductase NADPH small subunit
HFP99_16065	ENOG4107V9H	nitrite transporter
HFP99_16070	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HFP99_16075	ENOG4105CJW	magnesium transporter
HFP99_16080	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HFP99_16085	ENOG4105EX9	Membrane
HFP99_16095	ENOG4105CNG	UPF0061 protein
HFP99_16100	ENOG4105N7H	Cytochrome
HFP99_16105	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HFP99_16110	ENOG4108VUY	thioesterase Superfamily protein
HFP99_16125	ENOG4108RPX	mosc domain containing protein
HFP99_16130	ENOG4105D38	putrescine abc transporter
HFP99_16135	ENOG4105F38	ABC transporter, permease
HFP99_16140	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_16145	ENOG4108HM4	ABC transporter
HFP99_16155	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HFP99_16160	ENOG4105CFQ	glutamine synthetase
HFP99_16165	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFP99_16180	ENOG4108RH0	Crea protein
HFP99_16185	ENOG4105C5I	Dehydrogenase
HFP99_16190	ENOG4105R8A	Heat shock protein
HFP99_16205	ENOG4107R28	alpha amylase, catalytic region
HFP99_16215	ENOG4105EQQ	protein containing aminopeptidase domain
HFP99_16250	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HFP99_16255	ENOG4107EXC	regulatoR
HFP99_16265	ENOG4105JJR	Histidine kinase
HFP99_16275	ENOG4105C6K	Malic enzyme
HFP99_16280	ENOG4105CGD	Nad-dependent epimerase dehydratase
HFP99_16285	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HFP99_16290	ENOG4105C25	Primosomal protein n'
HFP99_16295	ENOG4105UYK	outer membrane protein a
HFP99_16300	ENOG4105C7B	Threonine dehydratase
HFP99_16305	ENOG4105C01	Dihydroxy-acid dehydratase
HFP99_16310	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HFP99_16315	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
HFP99_16325	ENOG4105C0P	Mg chelatase subunit ChlI
HFP99_16330	ENOG4106HNH	Acyl-transferase
HFP99_16335	ENOG4106HNH	Acyl-transferase
HFP99_16340	ENOG4105EWC	Purine nucleoside phosphorylase
HFP99_16350	ENOG4108RWI	nicotinamidase
HFP99_16355	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HFP99_16360	ENOG4105EHI	Phosphonate ABC transporter, periplasmic
HFP99_16365	ENOG4108VA1	ABC transporter
HFP99_16370	ENOG4105S7S	phosphonate abc transporter
HFP99_16375	ENOG4108Z33	Thiol disulfide Interchange Protein
HFP99_16380	ENOG4105E27	serine threonine protein kinase
HFP99_16390	ENOG4105PC1	Conserved Protein
HFP99_16410	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HFP99_16415	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HFP99_16420	ENOG4105DSJ	YicC domain protein
HFP99_16430	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HFP99_16435	ENOG4105XA0	heptosyltransferase ii
HFP99_16440	ENOG4106WTF	Glycosyl transferase, family 2
HFP99_16445	ENOG4105M5K	heptosyltransferase
HFP99_16450	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HFP99_16455	ENOG4108MJ5	VirK protein
HFP99_16460	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HFP99_16470	ENOG4105W0E	50S ribosomal protein L33
HFP99_16475	ENOG4105KDC	50s ribosomal protein l28
HFP99_16480	ENOG4105W5Q	DNA repair protein (RadC
HFP99_16485	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HFP99_16490	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HFP99_16495	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HFP99_16510	ENOG4105D64	Mechanosensitive ion channel
HFP99_16515	ENOG4107QP8	phosphohexose isomerase
HFP99_16520	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HFP99_16525	ENOG4105EMY	transcriptional regulator
HFP99_16535	ENOG4105CD5	CoA-binding domain protein
HFP99_16565	ENOG4108Z0R	Transferase
HFP99_16570	ENOG4105C2M	dna polymerase I
HFP99_16575	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HFP99_16580	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HFP99_16590	ENOG4105D7W	serine acetyltransferase
HFP99_16595	ENOG41076HS	cation diffusion facilitator family transporter
HFP99_16600	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HFP99_16605	ENOG4105E0F	Histidine kinase
HFP99_16610	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HFP99_16615	ENOG4107R73	Mate efflux family protein
HFP99_16630	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HFP99_16635	ENOG4105E55	glycerol-3-phosphate acyltransferase
HFP99_16640	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HFP99_16645	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HFP99_16650	ENOG4105X6C	Flagellar basal body-associated protein FliL
HFP99_16665	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HFP99_16685	ENOG4105PF3	O-Antigen polymerase
HFP99_16695	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HFP99_16700	ENOG4107Z3H	Transcriptional regulator, TetR family
HFP99_16705	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HFP99_16710	ENOG4105CPQ	Dehydrogenase
HFP99_16720	ENOG4105BZU	Histidine kinase
HFP99_16725	ENOG4105C4R	Atp-dependent dna helicase
HFP99_16730	ENOG4105C9B	Cysteine desulfurase
HFP99_16735	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HFP99_16740	ENOG4105CUZ	uba thif-type nad fad binding protein
HFP99_16775	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HFP99_16780	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HFP99_16785	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HFP99_16790	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HFP99_16795	ENOG4105FCD	Major Facilitator
HFP99_16800	ENOG4105DY9	regulatoR
HFP99_16805	ENOG4108HRK	Histidine kinase
HFP99_16815	ENOG4105EU0	Major facilitator Superfamily
HFP99_16820	ENOG4105CBX	hi0933 family
HFP99_16825	ENOG41090A1	ferritin
HFP99_16830	ENOG4105BZU	Histidine kinase
HFP99_16835	ENOG4105RKW	reductase (By
HFP99_16840	ENOG4108M6U	Universal stress protein A
HFP99_16870	ENOG4105EMK	carboxylate amino acid amine transporter
HFP99_16885	ENOG4105DKP	glycosyl transferase, family 9
HFP99_16900	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HFP99_16905	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HFP99_16910	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HFP99_16920	ENOG4108EUD	Lysophospholipase
HFP99_16925	ENOG4105DQF	Hydrolase
HFP99_16960	ENOG4105Y7M	Transcriptional regulator, TetR family
HFP99_16965	ENOG410624X	efflux transporter, rnd family, mfp subunit
HFP99_16970	ENOG4105BZS	acriflavin resistance protein
HFP99_16980	ENOG4105DC8	reductase
HFP99_16985	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HFP99_16990	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HFP99_16995	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HFP99_17000	ENOG4105C08	Histidine kinase
HFP99_17005	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HFP99_17010	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_17025	ENOG4105JKW	Valine--pyruvate aminotransferase
HFP99_17030	ENOG4108ZNX	Heat shock protein
HFP99_17035	ENOG4108ZNX	Heat shock protein
HFP99_17040	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
HFP99_17045	ENOG4105ECQ	AraC Family Transcriptional Regulator
HFP99_17050	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_17055	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HFP99_17060	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HFP99_17065	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HFP99_17070	ENOG4105EAB	amino acid AbC transporter
HFP99_17075	ENOG4105E5Q	amino acid AbC transporter
HFP99_17080	ENOG4105CDA	abc transporter atp-binding protein
HFP99_17085	ENOG4105VG0	50S ribosomal protein l34
HFP99_17090	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HFP99_17095	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HFP99_17100	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HFP99_17105	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HFP99_17110	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HFP99_17115	ENOG4105J76	Periplasmic binding protein
HFP99_17120	ENOG4105E0A	ABC, transporter
HFP99_17125	ENOG4105IBP	Cyclic peptide transporter
HFP99_17130	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_17135	ENOG4105QTB	Flavodoxin
HFP99_17140	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HFP99_17145	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HFP99_17150	ENOG4107QJE	Chromosome Partitioning Protein
HFP99_17155	ENOG4105FA0	parb-like partition protein
HFP99_17165	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HFP99_17170	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_17175	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_17180	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_17185	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HFP99_17190	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HFP99_17195	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HFP99_17200	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HFP99_17205	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HFP99_17210	ENOG4105CT7	inner membrane cred family protein
HFP99_17220	ENOG4105EB3	Histidine kinase
HFP99_17225	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HFP99_17230	ENOG410804X	Transcriptional regulator
HFP99_17240	ENOG4105VJY	transcriptional regulator
HFP99_17260	ENOG4109015	Biopolymer transport protein exbD tolR
HFP99_17265	ENOG410822N	TonB family
HFP99_17310	ENOG4105DZC	cytosine deaminase
HFP99_17315	ENOG4105WMR	Protein CrcB homolog
HFP99_17320	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HFP99_17325	ENOG4105JC1	sterol-binding domain protein
HFP99_17330	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HFP99_17335	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HFP99_17340	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HFP99_17345	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HFP99_17350	ENOG4105F8V	Hydrolase, tatD family
HFP99_17355	ENOG4105D52	delta-aminolevulinic acid dehydratase
HFP99_17360	ENOG4105DGW	oligopeptidase A
HFP99_17365	ENOG4105BZU	Histidine kinase
HFP99_17370	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HFP99_17385	ENOG4105C9X	ppx gppa phosphatase
HFP99_17390	ENOG4105C1J	atp-dependent rna helicase
HFP99_17400	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HFP99_17410	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HFP99_17415	ENOG4107QK7	reductase
HFP99_17420	ENOG4105W0Z	cytoplasmic protein
HFP99_17435	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HFP99_17450	ENOG4108IV0	ABC, transporter
HFP99_17455	ENOG4105C0Z	ABC transporter
HFP99_17460	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HFP99_17465	ENOG4105C32	Amino acid ABC transporter (Permease)
HFP99_17470	ENOG4105CP9	extracellular ligand-binding receptor
HFP99_17475	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_17480	ENOG4108JUA	Transcriptional regulator
HFP99_17485	ENOG4105CNW	domain protein
HFP99_17490	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
HFP99_17500	ENOG4105HEE	Binding Domain protein
HFP99_17515	ENOG4105CIC	tryptophan-specific transport protein
HFP99_17520	ENOG4105CIC	tryptophan-specific transport protein
HFP99_17550	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HFP99_17555	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HFP99_17560	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HFP99_17565	ENOG4105D3W	isochorismatase
HFP99_17585	ENOG4108ZG0	Ompa motb domain protein
HFP99_17590	ENOG4105M4H	endoribonuclease L-psp
HFP99_17595	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HFP99_17615	ENOG4105E0F	Histidine kinase
HFP99_17625	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_17630	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HFP99_17635	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HFP99_17640	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
HFP99_17645	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HFP99_17650	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HFP99_17655	ENOG4108RR8	protoporphyrinogen oxidase
HFP99_17690	ENOG4105CQ4	Transcriptional regulator
HFP99_17695	ENOG4105CNT	hydrolase family 2
HFP99_17700	ENOG4105FK9	beta-D-galactosidase beta subunit
HFP99_17705	ENOG4105E5D	amino acid
HFP99_17710	ENOG4108Y51	tRNA-binding protein
HFP99_17715	ENOG4105E5D	amino acid
HFP99_17720	ENOG4105DHU	Bile acid
HFP99_17750	ENOG4105CR8	Transcriptional regulator
HFP99_17760	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HFP99_17785	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_17795	ENOG4105UIB	(ABC) transporter
HFP99_17800	ENOG4108JQ9	ABC transporter
HFP99_17805	ENOG4105DIH	basic membrane
HFP99_17820	ENOG4105C4R	Atp-dependent dna helicase
HFP99_17835	ENOG4108UK5	Transposase
HFP99_17840	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_17860	ENOG4105K3G	Periplasmic Protein
HFP99_17875	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_17885	ENOG41061EV	selenium-binding protein YdfZ
HFP99_17905	ENOG4108YH8	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
HFP99_17910	ENOG4105EJC	lysr family transcriptional regulator
HFP99_17915	ENOG410829K	Lysine exporter protein (Lyse ygga)
HFP99_17920	ENOG4105CUC	YeeE YedE family protein
HFP99_17925	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HFP99_17930	ENOG4105ECQ	AraC Family Transcriptional Regulator
HFP99_17935	ENOG4105FR1	rard protein
HFP99_17945	ENOG4105C26	Dehydrogenase
HFP99_17950	ENOG4108JCI	Transcriptional regulator
HFP99_17960	ENOG4105C26	Dehydrogenase
HFP99_17965	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HFP99_17970	ENOG4107R11	Transcriptional regulator
HFP99_17975	ENOG4108TFM	Kinase, PfkB family
HFP99_17995	ENOG4105CGY	Dna recombination protein
HFP99_18000	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HFP99_18005	ENOG4105C1A	potassium transporter peripheral membrane
HFP99_18010	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HFP99_18015	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HFP99_18020	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HFP99_18030	ENOG4105C79	DNA protecting protein DprA
HFP99_18035	ENOG4108RPN	Protein smg homolog
HFP99_18040	ENOG4108WI1	Dna topoisomerase
HFP99_18045	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HFP99_18050	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HFP99_18055	ENOG4105E2X	shikimate dehydrogenase
HFP99_18060	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HFP99_18065	ENOG4106RE7	Cytochrome
HFP99_18070	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HFP99_18075	ENOG4105XCT	Protein of unknown function (DUF2489)
HFP99_18080	ENOG4105D4P	Coproporphyrinogen iii oxidase
HFP99_18085	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HFP99_18090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HFP99_18095	ENOG4105CUX	Signal transduction histidine kinase
HFP99_18105	ENOG4105C5F	glutamine synthetase
HFP99_18110	ENOG4105CI3	gtp-binding protein typa
HFP99_18115	ENOG4107S2Z	UPF0761 membrane protein
HFP99_18120	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HFP99_18130	ENOG4105SUU	thioesterase domain
HFP99_18140	ENOG4105CB5	ATP-dependent DNA helicase recG
HFP99_18145	ENOG4105JIM	Phosphatidylserine synthase
HFP99_18150	ENOG4105C6Z	Gluconate
HFP99_18155	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HFP99_18160	ENOG4105C01	Dihydroxy-acid dehydratase
HFP99_18165	ENOG4108UHU	Aldolase
HFP99_18180	ENOG4105DIQ	Transcriptional regulator
HFP99_18190	ENOG41063SB	peptidase
HFP99_18195	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HFP99_18200	ENOG4107YZP	Rhodanese domain protein
HFP99_18205	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HFP99_18210	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HFP99_18215	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HFP99_18220	ENOG4105MJ2	Competence protein
HFP99_18225	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HFP99_18240	ENOG4105BZM	domain protein
HFP99_18245	ENOG4108RRZ	Transcription elongation factor GreB
HFP99_18255	ENOG4105E0F	Histidine kinase
HFP99_18265	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HFP99_18270	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HFP99_18275	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HFP99_18280	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HFP99_18285	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFP99_18290	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HFP99_18295	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HFP99_18300	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HFP99_18305	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HFP99_18310	ENOG41083MP	50s ribosomal protein l29
HFP99_18315	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HFP99_18320	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HFP99_18325	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HFP99_18330	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFP99_18335	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HFP99_18340	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HFP99_18345	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HFP99_18350	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HFP99_18355	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HFP99_18360	ENOG4105VPB	50S ribosomal protein L30
HFP99_18365	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HFP99_18370	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HFP99_18375	ENOG41067V7	50S ribosomal protein L36
HFP99_18380	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFP99_18385	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HFP99_18390	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HFP99_18395	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_18400	ENOG4108ZT0	50S ribosomal protein l17
HFP99_18450	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HFP99_18455	ENOG4108W5M	transcriptional regulator
HFP99_18460	ENOG4105EMU	Dehydrogenase
HFP99_18475	ENOG4105CUG	Oligopeptidase b
HFP99_18495	ENOG4107FS9	Membrane
HFP99_18510	ENOG4105JQN	Transcriptional regulator
HFP99_18525	ENOG4105VVZ	metal-binding protein
HFP99_18530	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HFP99_18550	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_18560	ENOG4107RZC	phospholipase d
HFP99_18570	ENOG4105EJ2	Transcriptional regulator
HFP99_18575	ENOG4108Y73	Membrane
HFP99_18585	ENOG4106H78	methyltransferase
HFP99_18590	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HFP99_18595	ENOG4105CAK	Cell division ATP-binding protein ftsE
HFP99_18600	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HFP99_18605	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_18610	ENOG41077A9	carbonic anhydrase
HFP99_18615	ENOG4105CZE	histidine utilization repressor
HFP99_18620	ENOG4105CI2	imidazolone-5-propionate hydrolase
HFP99_18625	ENOG41088SP	formiminoglutamate hydrolase
HFP99_18630	ENOG4105CGP	Urocanate hydratase
HFP99_18635	ENOG4105C84	Histidine ammonia-lyase
HFP99_18640	ENOG4105EWV	Sodium calcium exchanger membrane region
HFP99_18645	ENOG4107XTP	(EAL) domain protein
HFP99_18700	ENOG4105D7Q	type ii secretion system
HFP99_18715	ENOG4108VAU	general secretion pathway protein G
HFP99_18750	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HFP99_18755	ENOG4105VQ7	Rod shape-determining protein MreD
HFP99_18760	ENOG4108Z03	MAF-like protein
HFP99_18765	ENOG4105C03	ribonuclease
HFP99_18770	ENOG4105QD6	exported protein
HFP99_18780	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HFP99_18795	ENOG4105CSH	Transporter
HFP99_18805	ENOG4105CGZ	zinc metallopeptidase
HFP99_18825	ENOG4106H3A	restriction
HFP99_18830	ENOG4105CVR	type I restriction-modification system
HFP99_18835	ENOG4105EKX	Restriction modification system DNA (Specificity
HFP99_18850	ENOG4105DZR	Type I site-specific deoxyribonuclease
HFP99_18855	ENOG41090ED	Protein with unknown function (DUF469)
HFP99_18885	ENOG4105DFP	Integrase
HFP99_18895	ENOG4105EEQ	Na H antiporter
HFP99_18900	ENOG4105C3R	Methionine synthase
HFP99_18910	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HFP99_18935	ENOG4108MR7	Arylsulfotransferase
HFP99_18940	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HFP99_18945	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HFP99_18950	ENOG4105D06	uba thif-type nad fad binding protein
HFP99_18960	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HFP99_18965	ENOG4105D41	biosynthesis protein thiH
HFP99_18970	ENOG4108UK5	Transposase
HFP99_18980	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
HFP99_18990	ENOG4105BZU	Histidine kinase
HFP99_18995	ENOG4108TPP	exopolysaccharide synthesis
HFP99_19010	ENOG4105N0V	mono-oxygenase ydhR
HFP99_19015	ENOG4105KVH	Transcriptional regulator
HFP99_19030	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_19035	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HFP99_19040	ENOG4105FCK	Membrane
HFP99_19045	ENOG4105CBT	Fructose-1,6-bisphosphatase
HFP99_19050	ENOG4105KRS	Proteinase inhibitor
HFP99_19055	ENOG410601J	HemY protein
HFP99_19060	ENOG4105ECF	c-methyltransferase
HFP99_19065	ENOG41076E6	Uroporphyrinogen-III Synthase
HFP99_19070	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HFP99_19075	ENOG4107T0K	Adenylate cyclase
HFP99_19080	ENOG4106CJB	Phospholipase Carboxylesterase
HFP99_19085	ENOG4105XQ6	frataxin-like protein
HFP99_19095	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HFP99_19100	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HFP99_19110	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HFP99_19115	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HFP99_19135	ENOG4108Z86	Glutamine amidotransferase
HFP99_19140	ENOG410667J	hydrolase
HFP99_19150	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
HFP99_19155	ENOG4108I62	cina-like protein
HFP99_19165	ENOG4105CVG	Homoserine O-transsuccinylase
HFP99_19175	ENOG4108YXU	transcriptional regulator AsnC family
HFP99_19180	ENOG4105E0M	Sulfatase
HFP99_19195	ENOG4105KT7	mgtC SapB transporter
HFP99_19215	ENOG4105EMU	Dehydrogenase
HFP99_19230	ENOG4108I6A	alcohol dehydrogenase
HFP99_19270	ENOG4107IFA	Lipase (EC 3.1.1.3)
HFP99_19280	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HFP99_19285	ENOG4108UB4	uncharacterized protein ygjQ
HFP99_19290	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_19295	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
HFP99_19300	ENOG4108IPT	Naphthoate synthase
HFP99_19305	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HFP99_19310	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HFP99_19315	ENOG4105E4F	Isochorismate synthase
HFP99_19320	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HFP99_19325	ENOG4105D22	carbon starvation protein
HFP99_19330	ENOG4105VCD	cytoplasmic protein
HFP99_19335	ENOG4105CKI	cobalamin synthesis protein
HFP99_19360	ENOG4105C1J	atp-dependent rna helicase
HFP99_19365	ENOG4105D9N	nucleoside
HFP99_19370	ENOG4107VGF	ig domain protein group 2 domain protein
HFP99_19375	ENOG4108UPT	UPF0178 protein
HFP99_19400	ENOG4105E61	Mannitol repressor protein
HFP99_19405	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HFP99_19410	ENOG4105CTS	PTS system mannitol-specific
HFP99_19415	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
HFP99_19420	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HFP99_19425	ENOG4105NNS	Autoinducer synthesis protein
HFP99_19430	ENOG4105VJY	transcriptional regulator
HFP99_19435	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HFP99_19440	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HFP99_19445	ENOG4105D1S	lipid A biosynthesis
HFP99_19450	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HFP99_19455	ENOG4105DFG	type I secretion outer membrane protein
HFP99_19460	ENOG41087AY	ADP-Ribose pyrophosphatase
HFP99_19465	ENOG4108SX3	cytoplasmic protein
HFP99_19475	ENOG4105IPS	esterase
HFP99_19490	ENOG4105Y49	secretion protein, HlyD family
HFP99_19495	ENOG4105DSW	Fusaric acid resistance protein
HFP99_19500	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_19505	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_19525	ENOG4105KD7	acetyltransferase
HFP99_19560	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HFP99_19570	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_19590	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HFP99_19595	ENOG41087YS	Phage shock protein A
HFP99_19610	ENOG41082IR	Excinuclease ABC C subunit domain protein
HFP99_19615	ENOG4105FR1	rard protein
HFP99_19620	ENOG4108RG0	uracil-dna glycosylase
HFP99_19630	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_19635	ENOG4105FAV	ABC, transporter
HFP99_19640	ENOG4105FDK	ABC transporter
HFP99_19645	ENOG4105NXV	High-affinity zinc uptake system protein
HFP99_19665	ENOG4105DR5	peptidase
HFP99_19710	ENOG4107TH8	cina domain protein
HFP99_19715	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HFP99_19720	ENOG4105Y3E	Modulates RecA activity (By similarity)
HFP99_19725	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HFP99_19730	ENOG4105CFH	Aspartokinase
HFP99_19735	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HFP99_19770	ENOG41061WM	D-Alanyl-D-Alanine
HFP99_19775	ENOG4106W5V	Membrane
HFP99_19795	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HFP99_19800	ENOG4108M8S	permease YjgP YjgQ family protein
HFP99_19805	ENOG4108K5H	permease YjgP YjgQ family protein
HFP99_19825	ENOG4105BZU	Histidine kinase
HFP99_19830	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HFP99_19845	ENOG4105EYA	deoxyribonuclease
HFP99_19850	ENOG4105D9N	nucleoside
HFP99_19860	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HFP99_19865	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HFP99_19870	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HFP99_19875	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HFP99_19885	ENOG4108NST	exported protein
HFP99_19895	ENOG4105EAC	phosphoserine phosphatase
HFP99_19910	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HFP99_19920	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HFP99_19925	ENOG4105K70	DNA-binding protein
HFP99_19940	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_19945	ENOG4105MYN	Zinc uptake regulation protein
HFP99_19960	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HFP99_19965	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HFP99_19970	ENOG4105C1J	atp-dependent rna helicase
HFP99_19975	ENOG4105D1Q	UPF0246 protein
HFP99_19980	ENOG4105CZX	twitching motility protein
HFP99_19985	ENOG4105CZX	twitching motility protein
HFP99_19990	ENOG4105DFA	alanine racemase domain protein
HFP99_19995	ENOG4105II7	pyrroline-5-carboxylate reductase
HFP99_20000	ENOG4108VIA	integral membrane protein
HFP99_20005	ENOG4105VZ9	UPF0235 protein
HFP99_20025	ENOG4105XTV	UPF0231 protein
HFP99_20035	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HFP99_20040	ENOG4107QQ0	gntp family
HFP99_20045	ENOG4105BZW	Glycerate kinase
HFP99_20060	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_20065	ENOG4105D9N	nucleoside
HFP99_20080	ENOG4108YZN	class I peptide chain release factor
HFP99_20085	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_20095	ENOG4107QKW	extracellular solute-binding protein family 1
HFP99_20110	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_20115	ENOG4105EZR	dyp-type peroxidase family protein
HFP99_20120	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HFP99_20125	ENOG4105E5Z	arginine transporter ATP-binding subunit
HFP99_20130	ENOG4106PMH	Extracellular solute-binding protein family 3
HFP99_20135	ENOG4105GBT	ABC transporter
HFP99_20140	ENOG4105DMR	ABC, transporter
HFP99_20145	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HFP99_20150	ENOG4108UV7	flagellar protein motX
HFP99_20155	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HFP99_20165	ENOG4108JU6	CBS domain protein
HFP99_20170	ENOG4106KVJ	cytochrome C assembly protein
HFP99_20175	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFP99_20180	ENOG4105K5M	30s ribosomal protein S16
HFP99_20185	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HFP99_20190	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HFP99_20195	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HFP99_20210	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HFP99_20220	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HFP99_20225	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HFP99_20230	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HFP99_20240	ENOG41063Z6	transcriptional regulator, lysR family
HFP99_20245	ENOG41080HT	Transcriptional regulator, arsr family
HFP99_20250	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HFP99_20255	ENOG4105CJR	Integral membrane protein (MviN
HFP99_20260	ENOG4105DTN	riboflavin biosynthesis protein ribF
HFP99_20265	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HFP99_20270	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HFP99_20275	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HFP99_20280	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HFP99_20310	ENOG4105X0D	Fimbrial protein
HFP99_20340	ENOG4105C4K	Nad synthetase
HFP99_20345	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_20355	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HFP99_20360	ENOG4106TD9	Diguanylate cyclase
HFP99_20365	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HFP99_20370	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HFP99_20380	ENOG4107YB6	acetyltransferase, (GNAT) family
HFP99_20395	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HFP99_20400	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HFP99_20405	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HFP99_20410	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HFP99_20415	ENOG4105DP0	ferredoxin-NADP reductase
HFP99_20450	ENOG4105W39	Membrane
HFP99_20460	ENOG4105D9M	gamma-glutamylcysteine synthetase
HFP99_20465	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HFP99_20470	ENOG4108IJ0	Aspartate ammonia-lyase
HFP99_20475	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HFP99_20485	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HFP99_20490	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HFP99_20500	ENOG4105BZU	Histidine kinase
HFP99_20515	ENOG4105D3G	Pseudouridine synthase
HFP99_20520	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HFP99_20550	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_20560	ENOG4108I5D	sulfate abc transporter
HFP99_20565	ENOG4105ECW	sulfate abc transporter
HFP99_20570	ENOG4108IJ6	ABC transporter
HFP99_20575	ENOG4107R11	Transcriptional regulator
HFP99_20580	ENOG4108M1A	Chitin-binding protein
HFP99_20585	ENOG4108N3W	hemolysin secretion protein
HFP99_20610	ENOG4105G0K	glycine radical enzyme YjjI family
HFP99_20615	ENOG41076CZ	activating enzyme
HFP99_20630	ENOG4105CGF	Aromatic amino acid aminotransferase
HFP99_20660	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HFP99_20665	ENOG4105C1J	atp-dependent rna helicase
HFP99_20675	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_20685	ENOG4107QSI	ABC, transporter
HFP99_20695	ENOG4105EQK	-acetyltransferase
HFP99_20700	ENOG4106WH9	Protein of unknown function (DUF2753)
HFP99_20705	ENOG4105E39	Enoyl-CoA hydratase
HFP99_20720	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
HFP99_20725	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HFP99_20730	ENOG4105DVT	helicase
HFP99_20735	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HFP99_20740	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_20745	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HFP99_20750	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HFP99_20755	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HFP99_20760	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HFP99_20770	ENOG4105KJB	cyd operon protein YbgE
HFP99_20775	ENOG4107YD3	Thioesterase
HFP99_20780	ENOG4105E02	MotA TolQ exbB proton channel
HFP99_20785	ENOG4105M8F	Biopolymer transport protein exbD tolR
HFP99_20795	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HFP99_20800	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HFP99_20805	ENOG4105UFD	tol-pal system protein YbgF
HFP99_20870	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HFP99_20875	ENOG4105DSB	aldose 1-epimerase
HFP99_20880	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HFP99_20885	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HFP99_20890	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HFP99_20900	ENOG4105E0X	reductase
HFP99_20915	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HFP99_20920	ENOG4105K56	Transcriptional regulator
HFP99_20935	ENOG4105EW9	transcriptional regulator AsnC family
HFP99_20950	ENOG410667J	hydrolase
HFP99_20970	ENOG4105C8J	)-transporter
HFP99_20985	ENOG4107SQD	Transcriptional regulator, GntR family
HFP99_21010	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_21020	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
HFP99_21035	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HFP99_21040	ENOG4105BZU	Histidine kinase
HFP99_21050	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HFP99_21055	ENOG4105C09	Bile acid
HFP99_21060	ENOG4108MJ3	acetyltransferase
HFP99_21065	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_21085	ENOG4105DWY	Agmatine deiminase
HFP99_21090	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HFP99_21115	ENOG4105C1J	atp-dependent rna helicase
HFP99_21125	ENOG4107Y60	(LipO)protein
HFP99_21135	ENOG4106B0W	Curli production assembly transport component CsgG