locus-tag	class	description
HFP99_00010	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HFP99_00125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HFP99_00130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFP99_00170	COG0745	RESPONSE REGULATOR receiver
HFP99_00175	COG3104	oligopeptide transport
HFP99_00180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFP99_00185	COG1555	photosystem II stabilization
HFP99_00195	COG2350	Protein conserved in bacteria
HFP99_00200	COG2917	probably involved in intracellular septation
HFP99_00205	COG0076	glutamate decarboxylase activity
HFP99_00210	COG1272	protein, Hemolysin III
HFP99_00215	COG0569	domain protein
HFP99_00215	COG2985	domain, Protein
HFP99_00245	COG0477	Major facilitator Superfamily
HFP99_00250	COG0583	DNA-binding transcription factor activity
HFP99_00260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP99_00265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP99_00275	COG2731	YhcH YjgK YiaL family protein
HFP99_00285	COG0668	transmembrane transport
HFP99_00290	COG1376	ErfK ybiS ycfS ynhG family protein
HFP99_00295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP99_00310	COG0789	Transcriptional regulator
HFP99_00335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFP99_00345	COG0488	(ABC) transporter
HFP99_00350	COG0516	GMP reductase activity
HFP99_00350	COG0517	IMP dehydrogenase activity
HFP99_00355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HFP99_00360	COG0835	chemotaxis
HFP99_00360	COG0784	Response regulator, receiver
HFP99_00365	COG2755	lipolytic protein G-D-S-L family
HFP99_00370	COG4181	ATPase activity
HFP99_00375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFP99_00380	COG1090	epimerase
HFP99_00385	COG2200	EAL domain
HFP99_00390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP99_00395	COG2234	aminopeptidase activity
HFP99_00395	COG4935	Belongs to the peptidase S8 family
HFP99_00400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFP99_00405	COG3171	Protein conserved in bacteria
HFP99_00410	COG2066	Belongs to the glutaminase family
HFP99_00415	COG2897	thiosulfate sulfurtransferase activity
HFP99_00420	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_00480	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HFP99_00485	COG3300	MHYT domain
HFP99_00485	COG5001	Diguanylate cyclase
HFP99_00505	COG4628	conserved protein (DUF2132)
HFP99_00510	COG0688	phosphatidylethanolamine metabolic process
HFP99_00520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HFP99_00560	COG1278	Cold shock
HFP99_00570	COG0840	transmembrane signaling receptor activity
HFP99_00575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFP99_00625	COG0848	biopolymer transport protein
HFP99_00630	COG0811	peptide transport
HFP99_00635	COG0811	peptide transport
HFP99_00645	COG4206	TonB-dependent receptor
HFP99_00650	COG4174	ABC transporter (Permease)
HFP99_00655	COG4239	(ABC) transporter, permease
HFP99_00665	COG0444	Belongs to the ABC transporter superfamily
HFP99_00670	COG4608	Belongs to the ABC transporter superfamily
HFP99_00675	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFP99_00680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HFP99_00700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFP99_00725	COG0243	molybdopterin cofactor binding
HFP99_00740	COG1116	anion transmembrane transporter activity
HFP99_00740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFP99_00750	COG1116	anion transmembrane transporter activity
HFP99_00755	COG2146	nitrite reductase [NAD(P)H] activity
HFP99_00755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP99_00760	COG2146	nitrite reductase [NAD(P)H] activity
HFP99_00760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP99_00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP99_00775	COG2313	pseudouridylate synthase activity
HFP99_00785	COG1858	cytochrome C peroxidase
HFP99_00800	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFP99_00810	COG2966	Psort location CytoplasmicMembrane, score
HFP99_00815	COG3610	response to peptide
HFP99_00825	COG4175	Glycine betaine
HFP99_00830	COG4176	ABC-type proline glycine betaine transport system permease component
HFP99_00840	COG0175	sulfate reduction
HFP99_00845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP99_00855	COG0384	phenazine biosynthesis protein PhzF
HFP99_00860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HFP99_00875	COG0786	glutamate:sodium symporter activity
HFP99_00880	COG0252	asparaginase activity
HFP99_00885	COG3139	Protein of unknown function (DUF1315)
HFP99_00905	COG0616	signal peptide processing
HFP99_00910	COG1902	pentaerythritol trinitrate reductase activity
HFP99_00910	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP99_00915	COG0778	Nitroreductase
HFP99_00925	COG2264	protein methyltransferase activity
HFP99_00930	COG0604	alcohol dehydrogenase
HFP99_00935	COG0583	DNA-binding transcription factor activity
HFP99_00940	COG2190	(PTS) system
HFP99_00940	COG1263	PTS System
HFP99_00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFP99_00945	COG4145	pantothenate transmembrane transporter activity
HFP99_00950	COG3924	membrane
HFP99_00955	COG0439	Biotin carboxylase
HFP99_00960	COG0511	ligase activity, forming carbon-carbon bonds
HFP99_00965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HFP99_00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP99_00985	COG3381	protein complex oligomerization
HFP99_00995	COG3005	denitrification pathway
HFP99_01000	COG0745	RESPONSE REGULATOR receiver
HFP99_01010	COG0784	Response regulator, receiver
HFP99_01010	COG2205	protein histidine kinase activity
HFP99_01010	COG2198	Histidine kinase
HFP99_01020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFP99_01030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFP99_01035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFP99_01035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFP99_01050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HFP99_01055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFP99_01060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFP99_01065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFP99_01070	COG4172	Belongs to the ABC transporter superfamily
HFP99_01090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFP99_01095	COG0142	geranyltranstransferase activity
HFP99_01100	COG1722	exodeoxyribonuclease VII activity
HFP99_01105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HFP99_01110	COG1360	Flagellar Motor Protein
HFP99_01120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP99_01125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFP99_01145	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HFP99_01160	COG1534	Rna-binding protein
HFP99_01165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HFP99_01175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFP99_01180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFP99_01185	COG0149	triose-phosphate isomerase activity
HFP99_01190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFP99_01205	COG0779	Required for maturation of 30S ribosomal subunits
HFP99_01210	COG0195	Participates in both transcription termination and antitermination
HFP99_01215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HFP99_01220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFP99_01225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFP99_01230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFP99_01235	COG1185	polyribonucleotide nucleotidyltransferase activity
HFP99_01240	COG2211	Major facilitator Superfamily
HFP99_01245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFP99_01250	COG1422	Protein of unknown function (DUF1090)
HFP99_01255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFP99_01275	COG0312	modulator of DNA gyrase
HFP99_01290	COG4974	Belongs to the 'phage' integrase family
HFP99_01325	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HFP99_01335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFP99_01340	COG0321	lipoyl(octanoyl) transferase activity
HFP99_01345	COG2921	Belongs to the UPF0250 family
HFP99_01350	COG1686	Belongs to the peptidase S11 family
HFP99_01355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFP99_01360	COG2951	lytic endotransglycosylase activity
HFP99_01365	COG0772	Belongs to the SEDS family
HFP99_01370	COG0772	Belongs to the SEDS family
HFP99_01375	COG0768	penicillin binding
HFP99_01380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HFP99_01385	COG0799	negative regulation of ribosome biogenesis
HFP99_01390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFP99_01405	COG0495	leucyl-tRNA aminoacylation
HFP99_01410	COG2888	peptidyl-tyrosine sulfation
HFP99_01415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HFP99_01420	COG4535	Mg2 and Co2 transporter CorC
HFP99_01430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HFP99_01435	COG1702	phosphate starvation-inducible protein PhoH
HFP99_01440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFP99_01445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP99_01455	COG0583	DNA-binding transcription factor activity
HFP99_01465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP99_01475	COG3706	GGDEF domain
HFP99_01485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFP99_01495	COG3647	Membrane
HFP99_01500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFP99_01510	COG0516	GMP reductase activity
HFP99_01520	COG0642	Histidine kinase
HFP99_01525	COG0745	RESPONSE REGULATOR receiver
HFP99_01535	COG0300	oxidoreductase activity
HFP99_01545	COG1022	Amp-dependent synthetase and ligase
HFP99_01555	COG4106	trans-aconitate 2-methyltransferase activity
HFP99_01560	COG3214	Protein conserved in bacteria
HFP99_01565	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HFP99_01570	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HFP99_01575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFP99_01580	COG1053	succinate dehydrogenase
HFP99_01590	COG0584	glycerophosphoryl diester phosphodiesterase
HFP99_01595	COG1511	domain protein
HFP99_01595	COG3264	Mechanosensitive ion channel
HFP99_01605	COG0739	heme binding
HFP99_01615	COG3121	Chaperone
HFP99_01625	COG3121	Chaperone
HFP99_01640	COG0583	DNA-binding transcription factor activity
HFP99_01655	COG0583	DNA-binding transcription factor activity
HFP99_01660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HFP99_01690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFP99_01695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HFP99_01705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HFP99_01710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFP99_01715	COG0546	phosphoglycolate phosphatase activity
HFP99_01720	COG0180	Tryptophanyl-tRNA synthetase
HFP99_01735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFP99_01745	COG1012	belongs to the aldehyde dehydrogenase family
HFP99_01755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP99_01770	COG0488	(ABC) transporter
HFP99_01780	COG0366	Alpha amylase catalytic
HFP99_01800	COG0471	metal ion transport
HFP99_01800	COG0490	domain, Protein
HFP99_01845	COG0012	GTP binding
HFP99_01855	COG0193	aminoacyl-tRNA hydrolase activity
HFP99_01860	COG0737	Belongs to the 5'-nucleotidase family
HFP99_01865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFP99_01875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HFP99_01880	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HFP99_01885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HFP99_01890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFP99_01895	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP99_01905	COG2912	Transglutaminase-like superfamily
HFP99_01915	COG1301	dicarboxylic acid transport
HFP99_01940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFP99_01945	COG1115	amino acid carrier protein
HFP99_01965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFP99_01975	COG0189	ligase activity
HFP99_01980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFP99_01990	COG3091	SprT-like family
HFP99_02000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFP99_02015	COG0456	acetyltransferase
HFP99_02025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HFP99_02030	COG0739	heme binding
HFP99_02035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFP99_02040	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HFP99_02040	COG3408	Glycogen debranching enzyme
HFP99_02055	COG3158	transport of potassium into the cell
HFP99_02065	COG0784	Response regulator, receiver
HFP99_02065	COG2205	protein histidine kinase activity
HFP99_02090	COG2205	protein histidine kinase activity
HFP99_02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_02095	COG3384	dioxygenase
HFP99_02100	COG0545	Peptidyl-prolyl cis-trans isomerase
HFP99_02120	COG0531	amino acid
HFP99_02125	COG0531	amino acid
HFP99_02140	COG1917	Cupin 2, conserved barrel domain protein
HFP99_02140	COG1396	sequence-specific DNA binding
HFP99_02145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP99_02190	COG2974	May be involved in recombination
HFP99_02195	COG0456	acetyltransferase
HFP99_02200	COG0420	3'-5' exonuclease activity
HFP99_02205	COG0419	ATPase involved in DNA repair
HFP99_02210	COG3038	cytochrome b561
HFP99_02215	COG2190	(PTS) system
HFP99_02225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_02230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFP99_02235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFP99_02255	COG1720	tRNA m6t6A37 methyltransferase activity
HFP99_02275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFP99_02280	COG4988	ABC transporter
HFP99_02295	COG0745	RESPONSE REGULATOR receiver
HFP99_02305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFP99_02320	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HFP99_02325	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HFP99_02335	COG0083	homoserine kinase activity
HFP99_02340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFP99_02345	COG4319	ketosteroid isomerase
HFP99_02365	COG3220	belongs to the UPF0276 family
HFP99_02395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HFP99_02400	COG1289	transmembrane transporter activity
HFP99_02405	COG1763	Mo-molybdopterin cofactor biosynthetic process
HFP99_02410	COG0746	molybdenum cofactor guanylyltransferase activity
HFP99_02440	COG2706	6-phosphogluconolactonase activity
HFP99_02450	COG3264	Mechanosensitive ion channel
HFP99_02450	COG1196	nuclear chromosome segregation
HFP99_02455	COG0469	pyruvate kinase activity
HFP99_02460	COG2850	peptidyl-arginine hydroxylation
HFP99_02465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFP99_02470	COG2915	High frequency lysogenization protein hflD homolog
HFP99_02475	COG0482	sulfurtransferase activity
HFP99_02495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_02505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_02505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_02505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_02520	COG0583	DNA-binding transcription factor activity
HFP99_02530	COG1940	carbohydrate kinase activity
HFP99_02540	COG2814	Major facilitator Superfamily
HFP99_02540	COG0477	Major facilitator Superfamily
HFP99_02550	COG5492	domain, Protein
HFP99_02550	COG4932	domain protein
HFP99_02555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_02570	COG1482	cell wall glycoprotein biosynthetic process
HFP99_02575	COG2207	Transcriptional regulator
HFP99_02580	COG0538	isocitrate dehydrogenase activity
HFP99_02590	COG3048	D-serine ammonia-lyase activity
HFP99_02595	COG2610	gluconate transmembrane transporter activity
HFP99_02600	COG0583	DNA-binding transcription factor activity
HFP99_02605	COG2916	Histone family protein nucleoid-structuring protein H-NS
HFP99_02610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFP99_02615	COG2375	cellular response to nickel ion
HFP99_02625	COG1136	(ABC) transporter
HFP99_02625	COG0577	efflux transmembrane transporter activity
HFP99_02630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_02640	COG1227	inorganic diphosphatase activity
HFP99_02650	COG3706	GGDEF domain
HFP99_02655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFP99_02660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFP99_02665	COG0443	Heat shock 70 kDa protein
HFP99_02670	COG0484	heat shock protein binding
HFP99_02700	COG1285	pathogenesis
HFP99_02715	COG0640	Transcriptional regulator
HFP99_02740	COG1566	PFAM secretion protein HlyD family protein
HFP99_02745	COG0577	efflux transmembrane transporter activity
HFP99_02745	COG1136	(ABC) transporter
HFP99_02750	COG0577	efflux transmembrane transporter activity
HFP99_02750	COG1136	(ABC) transporter
HFP99_02755	COG1136	(ABC) transporter
HFP99_02755	COG0577	efflux transmembrane transporter activity
HFP99_02760	COG0095	Lipoate-protein ligase
HFP99_02775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_02790	COG0708	Exodeoxyribonuclease III
HFP99_02805	COG0071	Belongs to the small heat shock protein (HSP20) family
HFP99_02815	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HFP99_02835	COG0583	DNA-binding transcription factor activity
HFP99_02840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFP99_02845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFP99_02850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFP99_02855	COG1845	cytochrome c oxidase, subunit III
HFP99_02860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFP99_02865	COG0109	protoheme IX farnesyltransferase activity
HFP99_02875	COG2814	Major facilitator Superfamily
HFP99_02880	COG5507	3-demethylubiquinone-9 3-methyltransferase
HFP99_02890	COG0583	DNA-binding transcription factor activity
HFP99_02910	COG3550	peptidyl-serine autophosphorylation
HFP99_02915	COG1396	sequence-specific DNA binding
HFP99_02930	COG0159	tryptophan synthase activity
HFP99_02935	COG0133	tryptophan synthase activity
HFP99_02940	COG0134	indole-3-glycerol-phosphate synthase activity
HFP99_02940	COG0135	phosphoribosylanthranilate isomerase activity
HFP99_02945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFP99_02950	COG0512	Glutamine amidotransferase of anthranilate synthase
HFP99_02950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFP99_02955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFP99_02960	COG0613	PHP domain protein
HFP99_02965	COG0009	L-threonylcarbamoyladenylate synthase
HFP99_02975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFP99_02985	COG1946	Acyl-CoA thioesterase
HFP99_03000	COG1309	transcriptional regulator
HFP99_03005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_03010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_03020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_03030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFP99_03040	COG1960	acyl-CoA dehydrogenase activity
HFP99_03045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_03055	COG0469	pyruvate kinase activity
HFP99_03060	COG1737	Transcriptional regulator
HFP99_03065	COG0837	glucose binding
HFP99_03070	COG2205	protein histidine kinase activity
HFP99_03085	COG1091	dTDP-4-dehydrorhamnose reductase activity
HFP99_03115	COG1442	glycosyl transferase family 8
HFP99_03115	COG1216	Glycosyl transferase, family 2
HFP99_03130	COG1215	transferase activity, transferring glycosyl groups
HFP99_03135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HFP99_03160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFP99_03185	COG3132	Protein of unknown function, DUF480
HFP99_03225	COG1278	Cold shock
HFP99_03255	COG0697	spore germination
HFP99_03270	COG1187	pseudouridine synthase activity
HFP99_03280	COG4166	transmembrane transport
HFP99_03285	COG0622	Phosphoesterase
HFP99_03300	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HFP99_03305	COG0835	chemotaxis
HFP99_03305	COG0784	Response regulator, receiver
HFP99_03310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HFP99_03315	COG1815	bacterial-type flagellum-dependent cell motility
HFP99_03345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HFP99_03350	COG1706	bacterial-type flagellum-dependent cell motility
HFP99_03355	COG3951	Flagellar rod assembly protein muramidase FlgJ
HFP99_03355	COG1705	Flagellar rod assembly protein muramidase FlgJ
HFP99_03370	COG2239	Acts as a magnesium transporter
HFP99_03380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HFP99_03385	COG2716	regulation of RNA biosynthetic process
HFP99_03400	COG3852	Histidine kinase
HFP99_03410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFP99_03445	COG2373	Large extracellular alpha-helical protein
HFP99_03450	COG4953	penicillin-binding protein 1C
HFP99_03460	COG0301	tRNA thio-modification
HFP99_03460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP99_03515	COG2089	acid synthase
HFP99_03530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFP99_03535	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HFP99_03545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFP99_03550	COG1086	Polysaccharide biosynthesis protein
HFP99_03555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFP99_03565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFP99_03585	COG0346	lactoylglutathione lyase activity
HFP99_03590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFP99_03595	COG4660	Part of a membrane complex involved in electron transport
HFP99_03600	COG4659	FMN binding
HFP99_03605	COG4658	electron transport chain
HFP99_03610	COG4656	Part of a membrane complex involved in electron transport
HFP99_03615	COG2878	Part of a membrane complex involved in electron transport
HFP99_03620	COG4657	Part of a membrane complex involved in electron transport
HFP99_03645	COG2932	Transcriptional regulator
HFP99_03715	COG5566	PFAM Mor transcription activator
HFP99_03755	COG0640	Transcriptional regulator
HFP99_03765	COG4373	Mu-like prophage FluMu protein gp28
HFP99_03770	COG4383	Mu-like prophage protein gp29
HFP99_03790	COG4388	Caudovirus prohead serine protease
HFP99_03795	COG4397	Mu-like prophage major head subunit gpT
HFP99_03870	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFP99_03875	COG1288	antiporter activity
HFP99_03880	COG0436	Aminotransferase
HFP99_03890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFP99_03895	COG2027	D-alanyl-D-alanine carboxypeptidase
HFP99_03900	COG1061	Type III restriction enzyme res subunit
HFP99_03905	COG1566	PFAM secretion protein HlyD family protein
HFP99_03915	COG3264	Mechanosensitive ion channel
HFP99_03915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HFP99_03920	COG1966	Carbon starvation protein
HFP99_03925	COG3279	Response regulator of the LytR AlgR family
HFP99_03940	COG1454	alcohol dehydrogenase
HFP99_03940	COG1012	belongs to the aldehyde dehydrogenase family
HFP99_03945	COG2095	MarC family integral membrane protein
HFP99_03955	COG0601	transmembrane transport
HFP99_03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFP99_03965	COG0444	Belongs to the ABC transporter superfamily
HFP99_03980	COG0861	Integral membrane protein TerC family
HFP99_03985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFP99_03995	COG1301	dicarboxylic acid transport
HFP99_04010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFP99_04025	COG0537	adenosine 5'-monophosphoramidase activity
HFP99_04060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFP99_04065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFP99_04080	COG2354	Protein conserved in bacteria
HFP99_04095	COG3150	esterase
HFP99_04100	COG1252	NADH dehydrogenase
HFP99_04105	COG0393	Putative heavy-metal-binding
HFP99_04110	COG1368	sulfuric ester hydrolase activity
HFP99_04120	COG0527	aspartate kinase activity
HFP99_04125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFP99_04125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HFP99_04130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFP99_04170	COG1136	(ABC) transporter
HFP99_04190	COG2814	Major facilitator Superfamily
HFP99_04210	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HFP99_04210	COG0493	'glutamate synthase
HFP99_04215	COG0672	)-iron permease
HFP99_04250	COG2308	Evidence 4 Homologs of previously reported genes of
HFP99_04265	COG0659	secondary active sulfate transmembrane transporter activity
HFP99_04310	COG3501	Rhs element vgr protein
HFP99_04320	COG3209	COG3209 Rhs family protein
HFP99_04420	COG3501	Rhs element vgr protein
HFP99_04445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HFP99_04450	COG0437	4 iron, 4 sulfur cluster binding
HFP99_04455	COG5557	Pfam Polysulphide reductase, NrfD
HFP99_04460	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFP99_04465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HFP99_04470	COG1773	rubredoxin
HFP99_04485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFP99_04495	COG3842	ATPase activity
HFP99_04500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HFP99_04505	COG0375	protein maturation
HFP99_04510	COG0309	Hydrogenase expression formation protein (HypE)
HFP99_04520	COG0298	carbon dioxide binding
HFP99_04525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HFP99_04530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFP99_04535	COG0326	Molecular chaperone. Has ATPase activity
HFP99_04540	COG0563	adenylate kinase activity
HFP99_04545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HFP99_04555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP99_04560	COG0840	transmembrane signaling receptor activity
HFP99_04575	COG3300	MHYT domain
HFP99_04575	COG5001	Diguanylate cyclase
HFP99_04580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFP99_04605	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFP99_04610	COG1535	isochorismatase
HFP99_04610	COG3433	isochorismatase activity
HFP99_04615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFP99_04620	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_04630	COG0300	oxidoreductase activity
HFP99_04630	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_04630	COG3321	synthase
HFP99_04630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFP99_04630	COG0318	PFAM AMP-dependent synthetase and ligase
HFP99_04635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFP99_04640	COG2977	Belongs to the P-Pant transferase superfamily
HFP99_04645	COG1120	ATPase activity
HFP99_04650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP99_04655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP99_04660	COG4771	TonB-dependent receptor
HFP99_04685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFP99_04685	COG0644	oxidoreductase
HFP99_04705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HFP99_04710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFP99_04715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFP99_04720	COG0861	Integral membrane protein TerC family
HFP99_04735	COG1022	Amp-dependent synthetase and ligase
HFP99_04740	COG0295	cytidine deaminase activity
HFP99_04745	COG1346	cytolysis
HFP99_04750	COG1380	Effector of murein hydrolase LrgA
HFP99_04755	COG3345	alpha-galactosidase
HFP99_04765	COG2925	Exonuclease
HFP99_04785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFP99_04825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HFP99_04855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFP99_04895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFP99_04905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFP99_04910	COG0436	Aminotransferase
HFP99_04915	COG0583	DNA-binding transcription factor activity
HFP99_04920	COG2160	L-arabinose isomerase activity
HFP99_04930	COG1069	ribulokinase activity
HFP99_04935	COG1879	ABC-type sugar transport system periplasmic component
HFP99_04945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP99_04955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFP99_04960	COG0254	rRNA binding
HFP99_04970	COG2731	YhcH YjgK YiaL family protein
HFP99_04975	COG0800	Aldolase
HFP99_04980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP99_04985	COG1414	Transcriptional regulator
HFP99_04995	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_05015	COG1451	nucleotide metabolic process
HFP99_05030	COG3069	C4-dicarboxylate transmembrane transporter activity
HFP99_05040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HFP99_05040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP99_05045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFP99_05070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFP99_05075	COG1053	succinate dehydrogenase
HFP99_05085	COG0567	Dehydrogenase, E1 component
HFP99_05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP99_05095	COG0045	succinate-CoA ligase (ADP-forming) activity
HFP99_05100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFP99_05110	COG2983	Belongs to the UPF0260 family
HFP99_05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP99_05125	COG3842	ATPase activity
HFP99_05130	COG1840	ABC-type Fe3 transport system, periplasmic component
HFP99_05140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HFP99_05150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP99_05155	COG1882	Formate acetyltransferase
HFP99_05160	COG2116	formate transmembrane transporter activity
HFP99_05165	COG1944	ATP diphosphatase activity
HFP99_05180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFP99_05185	COG1278	Cold shock
HFP99_05190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFP99_05195	COG0542	response to heat
HFP99_05200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFP99_05205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HFP99_05210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HFP99_05215	COG3134	Outer membrane lipoprotein
HFP99_05220	COG3706	GGDEF domain
HFP99_05225	COG0492	ferredoxin-NADP+ reductase activity
HFP99_05230	COG0686	Belongs to the AlaDH PNT family
HFP99_05240	COG1674	ftsk spoiiie
HFP99_05240	COG0531	amino acid
HFP99_05245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFP99_05250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFP99_05255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HFP99_05260	COG1286	toxin biosynthetic process
HFP99_05265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFP99_05270	COG2723	6-phospho-beta-galactosidase activity
HFP99_05275	COG1263	PTS System
HFP99_05275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFP99_05280	COG1609	Transcriptional regulator
HFP99_05290	COG4172	Belongs to the ABC transporter superfamily
HFP99_05310	COG4168	peptide transport system, permease
HFP99_05320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFP99_05325	COG1842	Phage shock protein A
HFP99_05340	COG3106	COG3106 Predicted ATPase
HFP99_05345	COG3768	UPF0283 membrane protein
HFP99_05355	COG2154	pterin-4-alpha-carbinolamine dehydratase
HFP99_05370	COG2199	diguanylate cyclase activity
HFP99_05375	COG2885	chlorophyll binding
HFP99_05385	COG1570	exodeoxyribonuclease VII activity
HFP99_05400	COG0516	GMP reductase activity
HFP99_05400	COG0517	IMP dehydrogenase activity
HFP99_05405	COG0519	Catalyzes the synthesis of GMP from XMP
HFP99_05405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFP99_05440	COG2062	phosphohistidine phosphatase, SixA
HFP99_05450	COG0697	spore germination
HFP99_05455	COG4166	transmembrane transport
HFP99_05460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HFP99_05475	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFP99_05480	COG1136	(ABC) transporter
HFP99_05485	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFP99_05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
HFP99_05505	COG0740	serine-type endopeptidase activity
HFP99_05510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HFP99_05515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFP99_05520	COG0776	regulation of translation
HFP99_05525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFP99_05530	COG0488	(ABC) transporter
HFP99_05535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP99_05540	COG3162	membrane
HFP99_05555	COG1024	Enoyl-CoA hydratase
HFP99_05560	COG1115	amino acid carrier protein
HFP99_05575	COG1584	GPR1 FUN34 yaaH family protein
HFP99_05605	COG1024	Enoyl-CoA hydratase
HFP99_05610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFP99_05615	COG1960	acyl-CoA dehydrogenase activity
HFP99_05625	COG1960	acyl-CoA dehydrogenase activity
HFP99_05630	COG1024	Enoyl-CoA hydratase
HFP99_05635	COG1024	Enoyl-CoA hydratase
HFP99_05645	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_05655	COG0730	response to heat
HFP99_05665	COG0583	DNA-binding transcription factor activity
HFP99_05675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP99_05680	COG0583	DNA-binding transcription factor activity
HFP99_05690	COG0583	DNA-binding transcription factor activity
HFP99_05695	COG1979	alcohol dehydrogenase
HFP99_05700	COG0667	Aldo Keto reductase
HFP99_05715	COG2814	Major facilitator Superfamily
HFP99_05720	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_05725	COG0656	L-ascorbic acid biosynthetic process
HFP99_05730	COG1464	Belongs to the NlpA lipoprotein family
HFP99_05745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP99_05750	COG1129	ABC transporter
HFP99_05755	COG1879	ABC-type sugar transport system periplasmic component
HFP99_05775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFP99_05780	COG0243	molybdopterin cofactor binding
HFP99_05795	COG3706	GGDEF domain
HFP99_05800	COG0583	DNA-binding transcription factor activity
HFP99_05805	COG2723	6-phospho-beta-galactosidase activity
HFP99_05810	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_05815	COG0583	DNA-binding transcription factor activity
HFP99_05830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HFP99_05835	COG0673	inositol 2-dehydrogenase activity
HFP99_05850	COG1560	Kdo2-lipid A biosynthetic process
HFP99_05855	COG1560	Kdo2-lipid A biosynthetic process
HFP99_05880	COG0417	DNA replication proofreading
HFP99_05910	COG0534	Mate efflux family protein
HFP99_05920	COG0307	riboflavin synthase, alpha
HFP99_05930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP99_05935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HFP99_05940	COG0697	spore germination
HFP99_05945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFP99_05985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFP99_05990	COG3099	Belongs to the UPF0263 family
HFP99_05995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HFP99_06000	COG2894	cell division
HFP99_06005	COG0850	regulation of cytokinetic process
HFP99_06010	COG3100	YcgL domain-containing protein
HFP99_06015	COG2951	lytic endotransglycosylase activity
HFP99_06020	COG1760	l-serine dehydratase
HFP99_06025	COG1760	l-serine dehydratase
HFP99_06030	COG3123	guanosine phosphorylase activity
HFP99_06050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HFP99_06055	COG2067	long-chain fatty acid transport protein
HFP99_06060	COG2067	long-chain fatty acid transport protein
HFP99_06080	COG2304	oxidoreductase activity
HFP99_06110	COG0714	Associated with various cellular activities
HFP99_06115	COG0183	Belongs to the thiolase family
HFP99_06120	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP99_06120	COG1024	Enoyl-CoA hydratase
HFP99_06130	COG4681	YaeQ
HFP99_06160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP99_06175	COG3134	Outer membrane lipoprotein
HFP99_06180	COG0318	PFAM AMP-dependent synthetase and ligase
HFP99_06210	COG0140	phosphoribosyl-ATP diphosphatase activity
HFP99_06210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFP99_06215	COG0107	imidazoleglycerol-phosphate synthase activity
HFP99_06220	COG0784	Response regulator, receiver
HFP99_06220	COG2198	Histidine kinase
HFP99_06220	COG2205	protein histidine kinase activity
HFP99_06230	COG3437	response regulator, receiver
HFP99_06235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HFP99_06240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFP99_06245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HFP99_06245	COG0131	Imidazoleglycerol-phosphate dehydratase
HFP99_06250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFP99_06255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFP99_06260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFP99_06270	COG1199	ATP-dependent helicase activity
HFP99_06275	COG1214	PFAM Peptidase M22, glycoprotease
HFP99_06285	COG0596	Alpha beta hydrolase
HFP99_06290	COG0318	PFAM AMP-dependent synthetase and ligase
HFP99_06305	COG0697	spore germination
HFP99_06315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFP99_06320	COG2832	Protein of unknown function (DUF454)
HFP99_06325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFP99_06335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFP99_06340	COG1335	isochorismatase
HFP99_06345	COG1335	isochorismatase
HFP99_06355	COG0583	DNA-binding transcription factor activity
HFP99_06365	COG2197	response regulator
HFP99_06370	COG0517	IMP dehydrogenase activity
HFP99_06370	COG0617	tRNA 3'-terminal CCA addition
HFP99_06370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HFP99_06375	COG1643	Atp-dependent helicase
HFP99_06385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HFP99_06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP99_06400	COG0709	Synthesizes selenophosphate from selenide and ATP
HFP99_06415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HFP99_06420	COG0840	transmembrane signaling receptor activity
HFP99_06425	COG1254	Belongs to the acylphosphatase family
HFP99_06435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP99_06435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP99_06440	COG0489	protein tyrosine kinase activity
HFP99_06445	COG0572	uridine kinase
HFP99_06450	COG0717	Belongs to the dCTP deaminase family
HFP99_06455	COG0306	phosphate transporter
HFP99_06510	COG1530	ribonuclease E activity
HFP99_06525	COG0424	maF-like protein
HFP99_06535	COG1399	metal-binding, possibly nucleic acid-binding protein
HFP99_06540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HFP99_06545	COG0416	fatty acid biosynthetic process
HFP99_06550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFP99_06560	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_06565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFP99_06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFP99_06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFP99_06585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HFP99_06590	COG0470	DNA polymerase III
HFP99_06595	COG0084	hydrolase, TatD family'
HFP99_06610	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HFP99_06610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFP99_06615	COG3008	intermembrane lipid transfer
HFP99_06620	COG2995	paraquat-inducible protein a
HFP99_06630	COG3141	response to X-ray
HFP99_06640	COG1067	ATP-dependent peptidase activity
HFP99_06645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HFP99_06660	COG0488	(ABC) transporter
HFP99_06670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HFP99_06670	COG0116	Belongs to the methyltransferase superfamily
HFP99_06680	COG0167	dihydroorotate dehydrogenase activity
HFP99_06685	COG2902	Dehydrogenase
HFP99_06695	COG0308	aminopeptidase N
HFP99_06710	COG1956	GAF domain-containing protein
HFP99_06720	COG3278	Belongs to the heme-copper respiratory oxidase family
HFP99_06735	COG2010	Cytochrome c
HFP99_06760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFP99_06765	COG0589	response to stress
HFP99_06770	COG0037	tRNA processing
HFP99_06790	COG1869	D-ribose catabolic process
HFP99_06795	COG1129	ABC transporter
HFP99_06800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP99_06805	COG1879	ABC-type sugar transport system periplasmic component
HFP99_06810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP99_06815	COG1609	Transcriptional regulator
HFP99_06820	COG5001	Diguanylate cyclase
HFP99_06820	COG3300	MHYT domain
HFP99_06845	COG2205	protein histidine kinase activity
HFP99_06845	COG0784	Response regulator, receiver
HFP99_06850	COG0776	regulation of translation
HFP99_06855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP99_06855	COG0072	phenylalanine-tRNA ligase activity
HFP99_06860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFP99_06865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFP99_06870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HFP99_06875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HFP99_06880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFP99_06915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFP99_06925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFP99_06930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFP99_06935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP99_06940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HFP99_06945	COG3313	Fe-S protein
HFP99_06950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_06950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP99_06950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFP99_06955	COG1105	Belongs to the carbohydrate kinase PfkB family
HFP99_06960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_06960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_06965	COG1609	Transcriptional regulator
HFP99_06970	COG0814	amino acid
HFP99_06980	COG5654	RES domain protein
HFP99_06985	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HFP99_06990	COG0513	Belongs to the DEAD box helicase family
HFP99_07000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HFP99_07005	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP99_07010	COG2840	Smr protein MutS2
HFP99_07045	COG2824	Alkylphosphonate utilization operon protein PhnA
HFP99_07070	COG0588	phosphoglycerate mutase activity
HFP99_07085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFP99_07090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HFP99_07150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HFP99_07155	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HFP99_07165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFP99_07170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HFP99_07180	COG0205	6-phosphofructokinase activity
HFP99_07190	COG1473	amidohydrolase
HFP99_07195	COG1011	Hydrolase
HFP99_07200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFP99_07265	COG0583	DNA-binding transcription factor activity
HFP99_07270	COG0730	response to heat
HFP99_07285	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFP99_07295	COG0386	Belongs to the glutathione peroxidase family
HFP99_07300	COG0513	Belongs to the DEAD box helicase family
HFP99_07315	COG1742	UPF0060 membrane protein
HFP99_07340	COG2329	Antibiotic biosynthesis monooxygenase
HFP99_07345	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HFP99_07375	COG2501	S4 domain
HFP99_07390	COG1132	(ABC) transporter
HFP99_07395	COG1132	(ABC) transporter
HFP99_07405	COG3118	belongs to the thioredoxin family
HFP99_07410	COG0471	metal ion transport
HFP99_07420	COG0058	SHG alpha-glucan phosphorylase activity
HFP99_07450	COG0814	amino acid
HFP99_07455	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HFP99_07460	COG0514	ATP-dependent DNA helicase (RecQ)
HFP99_07465	COG2766	serine protein kinase
HFP99_07470	COG2718	Belongs to the UPF0229 family
HFP99_07475	COG2719	SpoVR family
HFP99_07485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFP99_07490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HFP99_07495	COG0586	Pfam SNARE associated Golgi protein
HFP99_07505	COG0556	nucleotide-excision repair
HFP99_07515	COG2985	domain, Protein
HFP99_07515	COG0569	domain protein
HFP99_07520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HFP99_07540	COG4565	transcriptional regulatory protein
HFP99_07545	COG3290	protein histidine kinase activity
HFP99_07550	COG1846	Transcriptional regulator
HFP99_07550	COG1940	carbohydrate kinase activity
HFP99_07560	COG3012	SEC-C Motif Domain Protein
HFP99_07565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFP99_07570	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HFP99_07575	COG0247	lactate metabolic process
HFP99_07590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HFP99_07595	COG0437	4 iron, 4 sulfur cluster binding
HFP99_07600	COG3301	Polysulphide reductase, NrfD
HFP99_07605	COG1138	Cytochrome C-type biogenesis protein
HFP99_07615	COG3088	subunit of a heme lyase
HFP99_07615	COG4235	cytochrome complex assembly
HFP99_07635	COG3046	protein related to deoxyribodipyrimidine photolyase
HFP99_07640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP99_07655	COG0517	IMP dehydrogenase activity
HFP99_07665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HFP99_07670	COG0583	DNA-binding transcription factor activity
HFP99_07680	COG4774	siderophore transport
HFP99_07685	COG3706	GGDEF domain
HFP99_07690	COG3708	Transcriptional regulator
HFP99_07690	COG2207	Transcriptional regulator
HFP99_07700	COG0583	DNA-binding transcription factor activity
HFP99_07705	COG2910	NAD(P)H-binding
HFP99_07715	COG0626	cystathionine gamma-synthase activity
HFP99_07720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFP99_07740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HFP99_07760	COG2223	nitrite transmembrane transporter activity
HFP99_07780	COG1435	thymidine kinase activity
HFP99_07785	COG1757	Na H antiporter
HFP99_07790	COG2916	Histone family protein nucleoid-structuring protein H-NS
HFP99_07795	COG2096	Adenosyltransferase
HFP99_07800	COG3530	Putative quorum-sensing-regulated virulence factor
HFP99_07805	COG0602	queuosine metabolic process
HFP99_07810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HFP99_07830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HFP99_07840	COG0776	regulation of translation
HFP99_07845	COG0539	negative regulation of cytoplasmic translation
HFP99_07850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HFP99_07855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP99_07880	COG0778	Nitroreductase
HFP99_07885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HFP99_07890	COG3300	MHYT domain
HFP99_07890	COG5001	Diguanylate cyclase
HFP99_07900	COG0583	DNA-binding transcription factor activity
HFP99_07905	COG3437	response regulator, receiver
HFP99_07930	COG4989	oxidoreductase activity
HFP99_07935	COG0724	RNA recognition motif
HFP99_07955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFP99_07980	COG1360	Flagellar Motor Protein
HFP99_07985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP99_07990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP99_07995	COG0649	NAD binding
HFP99_07995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP99_08010	COG1034	ATP synthesis coupled electron transport
HFP99_08015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFP99_08020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP99_08025	COG0839	Belongs to the complex I subunit 6 family
HFP99_08030	COG0713	ATP synthesis coupled electron transport
HFP99_08040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP99_08045	COG1007	ATP synthesis coupled electron transport
HFP99_08050	COG0047	phosphoribosylformylglycinamidine synthase activity
HFP99_08050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFP99_08055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HFP99_08060	COG1645	bacterial-type flagellum-dependent swarming motility
HFP99_08065	COG1160	GTP binding
HFP99_08070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_08075	COG2976	Protein conserved in bacteria
HFP99_08080	COG0124	histidyl-tRNA synthetase
HFP99_08085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HFP99_08100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFP99_08105	COG0105	UTP biosynthetic process
HFP99_08120	COG0633	Ferredoxin
HFP99_08125	COG0443	Heat shock 70 kDa protein
HFP99_08130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HFP99_08140	COG0822	iron-sulfur transferase activity
HFP99_08145	COG1104	cysteine desulfurase activity
HFP99_08165	COG3154	lipid carrier protein
HFP99_08170	COG0826	peptidase U32
HFP99_08175	COG0826	peptidase U32
HFP99_08190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFP99_08195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFP99_08200	COG1862	Preprotein translocase
HFP99_08205	COG0343	queuine tRNA-ribosyltransferase activity
HFP99_08210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFP99_08215	COG0517	IMP dehydrogenase activity
HFP99_08225	COG3634	alkyl hydroperoxide reductase activity
HFP99_08240	COG2203	Gaf domain
HFP99_08240	COG2199	diguanylate cyclase activity
HFP99_08280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFP99_08280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFP99_08285	COG0509	glycine decarboxylation via glycine cleavage system
HFP99_08290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFP99_08295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP99_08300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP99_08320	COG1609	Transcriptional regulator
HFP99_08325	COG1129	ABC transporter
HFP99_08330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP99_08335	COG1879	ABC-type sugar transport system periplasmic component
HFP99_08345	COG0673	inositol 2-dehydrogenase activity
HFP99_08350	COG2814	Major facilitator Superfamily
HFP99_08360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFP99_08365	COG0601	transmembrane transport
HFP99_08375	COG0625	glutathione transferase activity
HFP99_08390	COG0483	inositol monophosphate 1-phosphatase activity
HFP99_08400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFP99_08405	COG2056	Na+-H+ antiporter family
HFP99_08410	COG2814	Major facilitator Superfamily
HFP99_08415	COG0583	DNA-binding transcription factor activity
HFP99_08420	COG0513	Belongs to the DEAD box helicase family
HFP99_08425	COG2050	protein possibly involved in aromatic compounds catabolism
HFP99_08435	COG0277	FAD linked oxidase domain protein
HFP99_08435	COG0247	lactate metabolic process
HFP99_08455	COG1902	pentaerythritol trinitrate reductase activity
HFP99_08465	COG0647	UMP catabolic process
HFP99_08475	COG0367	asparagine synthase
HFP99_08485	COG0625	glutathione transferase activity
HFP99_08495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HFP99_08510	COG0564	pseudouridine synthase activity
HFP99_08520	COG0840	transmembrane signaling receptor activity
HFP99_08525	COG0318	PFAM AMP-dependent synthetase and ligase
HFP99_08580	COG2814	Major facilitator Superfamily
HFP99_08585	COG3246	L-lysine catabolic process to acetate
HFP99_08590	COG2175	clavaminate synthase activity
HFP99_08600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HFP99_08625	COG0670	Belongs to the BI1 family
HFP99_08630	COG1289	transmembrane transporter activity
HFP99_08635	COG2920	part of a sulfur-relay system
HFP99_08640	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HFP99_08645	COG0285	dihydrofolate synthase activity
HFP99_08650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HFP99_08655	COG0101	tRNA pseudouridine synthase activity
HFP99_08665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFP99_08670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFP99_08675	COG0671	phosphoesterase, PA-phosphatase related
HFP99_08680	COG1464	Belongs to the NlpA lipoprotein family
HFP99_08695	COG1119	ATPase activity
HFP99_08710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFP99_08710	COG0574	Belongs to the PEP-utilizing enzyme family
HFP99_08715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HFP99_08770	COG1242	4 iron, 4 sulfur cluster binding
HFP99_08775	COG0067	glutamate synthase
HFP99_08775	COG0069	glutamate synthase activity
HFP99_08775	COG0070	glutamate synthase
HFP99_08780	COG0493	'glutamate synthase
HFP99_08795	COG0513	Belongs to the DEAD box helicase family
HFP99_08825	COG3706	GGDEF domain
HFP99_08830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFP99_08840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFP99_08845	COG0505	Belongs to the CarA family
HFP99_08850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HFP99_08860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFP99_08865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HFP99_08870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFP99_08875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HFP99_08880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFP99_08885	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HFP99_08930	COG0023	Translation Initiation Factor
HFP99_08935	COG2119	membrane
HFP99_08970	COG2199	diguanylate cyclase activity
HFP99_08970	COG2203	Gaf domain
HFP99_08975	COG1196	nuclear chromosome segregation
HFP99_08980	COG1074	ATP-dependent DNA helicase activity
HFP99_08995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFP99_09005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFP99_09010	COG2261	transglycosylase associated protein
HFP99_09015	COG0625	glutathione transferase activity
HFP99_09055	COG0322	excinuclease ABC activity
HFP99_09060	COG2197	response regulator
HFP99_09065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HFP99_09070	COG2835	tetraacyldisaccharide 4'-kinase activity
HFP99_09075	COG1663	tetraacyldisaccharide 4'-kinase activity
HFP99_09080	COG1132	(ABC) transporter
HFP99_09100	COG0433	COG0433 Predicted ATPase
HFP99_09105	COG1448	Aminotransferase
HFP99_09120	COG1199	ATP-dependent helicase activity
HFP99_09130	COG0123	including yeast histone deacetylase and acetoin utilization protein
HFP99_09135	COG0477	Major facilitator Superfamily
HFP99_09140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HFP99_09145	COG1785	Belongs to the alkaline phosphatase family
HFP99_09165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFP99_09170	COG2197	response regulator
HFP99_09190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_09195	COG0765	amino acid transport
HFP99_09200	COG1126	abc transporter atp-binding protein
HFP99_09215	COG0531	amino acid
HFP99_09230	COG1253	flavin adenine dinucleotide binding
HFP99_09245	COG0581	inorganic phosphate transmembrane transporter activity
HFP99_09250	COG0573	inorganic phosphate transmembrane transporter activity
HFP99_09255	COG0590	tRNA wobble adenosine to inosine editing
HFP99_09280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFP99_09300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFP99_09305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HFP99_09310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFP99_09320	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP99_09330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFP99_09350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_09365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFP99_09370	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HFP99_09380	COG1393	Belongs to the ArsC family
HFP99_09385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP99_09390	COG4783	chaperone-mediated protein folding
HFP99_09395	COG0425	Belongs to the sulfur carrier protein TusA family
HFP99_09425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_09435	COG3842	ATPase activity
HFP99_09440	COG3833	ABC-type maltose transport systems, permease component
HFP99_09445	COG1175	transmembrane transport
HFP99_09455	COG3081	Nucleoid-associated protein
HFP99_09460	COG3082	Protein of unknown function (DUF1414)
HFP99_09465	COG3083	sulfuric ester hydrolase activity
HFP99_09470	COG4771	TonB-dependent receptor
HFP99_09475	COG1770	oligopeptidase
HFP99_09495	COG4574	serine-type endopeptidase inhibitor activity
HFP99_09500	COG3085	chromosome segregation
HFP99_09510	COG0287	Prephenate dehydrogenase
HFP99_09510	COG1605	Chorismate mutase
HFP99_09515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFP99_09520	COG0584	glycerophosphoryl diester phosphodiesterase
HFP99_09530	COG1349	DNA-binding transcription factor activity
HFP99_09535	COG2271	Major facilitator Superfamily
HFP99_09540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFP99_09545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFP99_09550	COG0583	DNA-binding transcription factor activity
HFP99_09575	COG0656	L-ascorbic acid biosynthetic process
HFP99_09580	COG2814	Major facilitator Superfamily
HFP99_09590	COG1294	oxidase, subunit
HFP99_09600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP99_09605	COG2979	Protein of unknown function (DUF533)
HFP99_09635	COG0583	DNA-binding transcription factor activity
HFP99_09645	COG2807	transmembrane transport
HFP99_09650	COG1187	pseudouridine synthase activity
HFP99_09655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFP99_09675	COG1403	HNH endonuclease
HFP99_09690	COG1166	arginine decarboxylase activity
HFP99_09695	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFP99_09710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HFP99_09725	COG0583	DNA-binding transcription factor activity
HFP99_09735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HFP99_09745	COG0840	transmembrane signaling receptor activity
HFP99_09750	COG0302	gtp cyclohydrolase
HFP99_09760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFP99_09775	COG2267	carboxylic ester hydrolase activity
HFP99_09780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFP99_09795	COG0314	molybdopterin synthase activity
HFP99_09800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HFP99_09805	COG0315	cyclic pyranopterin monophosphate synthase activity
HFP99_09810	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFP99_09815	COG3005	denitrification pathway
HFP99_09825	COG0348	domain, Protein
HFP99_09830	COG0437	4 iron, 4 sulfur cluster binding
HFP99_09835	COG0243	molybdopterin cofactor binding
HFP99_09845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFP99_09850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFP99_09855	COG3850	Histidine kinase
HFP99_09860	COG2197	response regulator
HFP99_09885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HFP99_09895	COG0121	glutamine amidotransferase
HFP99_09900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HFP99_09910	COG3437	response regulator, receiver
HFP99_09910	COG0784	Response regulator, receiver
HFP99_09920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFP99_09925	COG0328	RNA-DNA hybrid ribonuclease activity
HFP99_09930	COG2226	methyltransferase
HFP99_09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP99_09940	COG0741	lytic transglycosylase activity
HFP99_09940	COG1388	LysM domain
HFP99_09955	COG1607	acyl-coa hydrolase
HFP99_09970	COG0741	lytic transglycosylase activity
HFP99_09980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFP99_10005	COG0729	surface antigen
HFP99_10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFP99_10025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFP99_10035	COG4134	Bacterial extracellular solute-binding protein
HFP99_10045	COG4136	ATPase activity
HFP99_10050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFP99_10055	COG2951	lytic endotransglycosylase activity
HFP99_10060	COG1846	Transcriptional regulator
HFP99_10070	COG0033	Phosphoglucomutase
HFP99_10075	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HFP99_10080	COG0596	Alpha beta hydrolase
HFP99_10095	COG0716	FMN binding
HFP99_10105	COG0735	belongs to the Fur family
HFP99_10110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFP99_10120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFP99_10125	COG2080	2 iron, 2 sulfur cluster binding
HFP99_10130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFP99_10130	COG2010	Cytochrome c
HFP99_10175	COG0463	Glycosyl transferase, family 2
HFP99_10210	COG2190	(PTS) system
HFP99_10210	COG1263	PTS System
HFP99_10210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFP99_10215	COG0363	glucosamine-6-phosphate deaminase activity
HFP99_10220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFP99_10225	COG1846	Transcriptional regulator
HFP99_10225	COG1940	carbohydrate kinase activity
HFP99_10235	COG0217	transcriptional regulatory protein
HFP99_10240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HFP99_10250	COG1801	Protein of unknown function DUF72
HFP99_10255	COG4106	trans-aconitate 2-methyltransferase activity
HFP99_10260	COG0500	methyltransferase
HFP99_10280	COG0583	DNA-binding transcription factor activity
HFP99_10285	COG0791	NLP P60 protein
HFP99_10300	COG1309	transcriptional regulator
HFP99_10335	COG0534	Mate efflux family protein
HFP99_10345	COG2841	Protein conserved in bacteria
HFP99_10350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFP99_10350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFP99_10350	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFP99_10350	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFP99_10360	COG0633	Ferredoxin
HFP99_10360	COG3217	Mosc domain protein beta barrel domain protein
HFP99_10360	COG0633	Ferredoxin
HFP99_10360	COG3217	Mosc domain protein beta barrel domain protein
HFP99_10365	COG0501	Belongs to the peptidase M48B family
HFP99_10370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HFP99_10375	COG2226	methyltransferase
HFP99_10375	COG1073	alpha beta
HFP99_10380	COG0156	8-amino-7-oxononanoate synthase activity
HFP99_10385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HFP99_10390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFP99_10405	COG0017	Asparaginyl-tRNA synthetase
HFP99_10410	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFP99_10425	COG3069	C4-dicarboxylate transmembrane transporter activity
HFP99_10435	COG1393	Belongs to the ArsC family
HFP99_10440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFP99_10445	COG1876	peptidase activity
HFP99_10455	COG3263	regulation of cellular component size
HFP99_10465	COG1280	lysine exporter protein (LysE YggA)
HFP99_10495	COG0564	pseudouridine synthase activity
HFP99_10505	COG1454	alcohol dehydrogenase
HFP99_10510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_10515	COG0702	epimerase
HFP99_10525	COG2867	negative regulation of translational initiation
HFP99_10530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HFP99_10540	COG0582	viral genome integration into host DNA
HFP99_10580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HFP99_10595	COG3153	acetyltransferase
HFP99_10625	COG0259	pyridoxamine-phosphate oxidase activity
HFP99_10640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFP99_10640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFP99_10645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFP99_10665	COG4235	cytochrome complex assembly
HFP99_10665	COG3088	subunit of a heme lyase
HFP99_10670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP99_10675	COG1138	Cytochrome C-type biogenesis protein
HFP99_10680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HFP99_10685	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFP99_10690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFP99_10695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFP99_10710	COG0835	chemotaxis
HFP99_10720	COG1192	Involved in chromosome partitioning
HFP99_10725	COG1360	Flagellar Motor Protein
HFP99_10730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HFP99_10735	COG2201	protein-glutamate methylesterase activity
HFP99_10740	COG0784	Response regulator, receiver
HFP99_10740	COG2198	Histidine kinase
HFP99_10740	COG0643	Histidine kinase
HFP99_10770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HFP99_10780	COG1684	flagellar biosynthetic protein fliR
HFP99_10835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HFP99_10845	COG1677	Flagellar hook-basal body complex protein FliE
HFP99_10860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFP99_10885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFP99_10890	COG0444	Belongs to the ABC transporter superfamily
HFP99_10895	COG4608	Belongs to the ABC transporter superfamily
HFP99_10905	COG2971	BadF BadG BcrA BcrD
HFP99_10915	COG0840	transmembrane signaling receptor activity
HFP99_10935	COG3724	N-succinylarginine dihydrolase activity
HFP99_10940	COG0616	signal peptide processing
HFP99_10945	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_10950	COG0583	DNA-binding transcription factor activity
HFP99_10960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFP99_10970	COG0583	DNA-binding transcription factor activity
HFP99_11005	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_11010	COG0583	DNA-binding transcription factor activity
HFP99_11030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP99_11035	COG2259	Doxx family
HFP99_11045	COG1388	LysM domain
HFP99_11045	COG1376	ErfK ybiS ycfS ynhG family protein
HFP99_11060	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HFP99_11065	COG0791	NLP P60 protein
HFP99_11075	COG3118	belongs to the thioredoxin family
HFP99_11085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP99_11090	COG0788	formyltetrahydrofolate deformylase activity
HFP99_11115	COG1196	nuclear chromosome segregation
HFP99_11115	COG0741	lytic transglycosylase activity
HFP99_11115	COG0739	heme binding
HFP99_11125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFP99_11130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HFP99_11135	COG0673	inositol 2-dehydrogenase activity
HFP99_11160	COG1943	Transposase
HFP99_11170	COG1032	radical SAM domain protein
HFP99_11180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_11190	COG3706	GGDEF domain
HFP99_11195	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFP99_11200	COG0733	neurotransmitter:sodium symporter activity
HFP99_11230	COG0281	malic enzyme
HFP99_11235	COG2207	Transcriptional regulator
HFP99_11240	COG0534	Mate efflux family protein
HFP99_11255	COG2233	PERMEase
HFP99_11260	COG0095	Lipoate-protein ligase
HFP99_11265	COG1115	amino acid carrier protein
HFP99_11270	COG0019	diaminopimelate decarboxylase activity
HFP99_11280	COG0678	peroxiredoxin activity
HFP99_11285	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HFP99_11295	COG1126	abc transporter atp-binding protein
HFP99_11300	COG0765	amino acid transport
HFP99_11305	COG4597	amino acid ABC transporter
HFP99_11310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_11325	COG1131	(ABC) transporter
HFP99_11330	COG0545	Peptidyl-prolyl cis-trans isomerase
HFP99_11350	COG4783	chaperone-mediated protein folding
HFP99_11360	COG5002	protein histidine kinase activity
HFP99_11365	COG0745	RESPONSE REGULATOR receiver
HFP99_11370	COG0346	lactoylglutathione lyase activity
HFP99_11375	COG3706	GGDEF domain
HFP99_11385	COG1012	belongs to the aldehyde dehydrogenase family
HFP99_11395	COG0697	spore germination
HFP99_11410	COG0281	malic enzyme
HFP99_11420	COG1846	Transcriptional regulator
HFP99_11425	COG1566	PFAM secretion protein HlyD family protein
HFP99_11455	COG0602	queuosine metabolic process
HFP99_11460	COG1328	CTP reductase activity
HFP99_11470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFP99_11475	COG3115	cell septum assembly
HFP99_11480	COG1196	nuclear chromosome segregation
HFP99_11490	COG2860	membrane
HFP99_11500	COG3108	Peptidase M15
HFP99_11505	COG2989	Protein conserved in bacteria
HFP99_11520	COG0463	Glycosyl transferase, family 2
HFP99_11535	COG0366	Alpha amylase catalytic
HFP99_11570	COG3706	GGDEF domain
HFP99_11580	COG3590	peptidase
HFP99_11590	COG0488	(ABC) transporter
HFP99_11600	COG0531	amino acid
HFP99_11605	COG0814	amino acid
HFP99_11610	COG0583	DNA-binding transcription factor activity
HFP99_11640	COG0825	malonyl-CoA metabolic process
HFP99_11650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFP99_11655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFP99_11660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFP99_11665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HFP99_11670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFP99_11685	COG0750	zinc metalloprotease
HFP99_11690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HFP99_11695	COG0575	Belongs to the CDS family
HFP99_11700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFP99_11705	COG0233	cytoplasmic translational termination
HFP99_11710	COG0528	UMP kinase activity
HFP99_11715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFP99_11720	COG0052	Belongs to the universal ribosomal protein uS2 family
HFP99_11725	COG0024	Methionine aminopeptidase
HFP99_11730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HFP99_11735	COG2171	N-acyltransferase activity
HFP99_11745	COG1263	PTS System
HFP99_11745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFP99_11755	COG4580	involved in the transport of maltose and maltodextrins
HFP99_11760	COG0716	FMN binding
HFP99_11765	COG0564	pseudouridine synthase activity
HFP99_11770	COG3098	single-species biofilm formation
HFP99_11795	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HFP99_11805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HFP99_11805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HFP99_11820	COG1611	Belongs to the LOG family
HFP99_11825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFP99_11830	COG0473	3-isopropylmalate dehydrogenase activity
HFP99_11840	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HFP99_11845	COG2363	Small membrane protein
HFP99_11855	COG0583	DNA-binding transcription factor activity
HFP99_11860	COG0840	transmembrane signaling receptor activity
HFP99_11865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFP99_11880	COG1477	protein flavinylation
HFP99_11885	COG2871	sodium ion transport
HFP99_11890	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HFP99_11895	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HFP99_11900	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HFP99_11905	COG1805	sodium ion transport
HFP99_11910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HFP99_11915	COG0271	Belongs to the BolA IbaG family
HFP99_11930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFP99_11940	COG2211	Major facilitator Superfamily
HFP99_11950	COG1666	GTP binding
HFP99_11955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFP99_11985	COG3501	Rhs element vgr protein
HFP99_11995	COG2771	luxR family
HFP99_12000	COG0659	secondary active sulfate transmembrane transporter activity
HFP99_12005	COG1393	Belongs to the ArsC family
HFP99_12010	COG0798	PFAM Bile acid sodium symporter
HFP99_12020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFP99_12060	COG0745	RESPONSE REGULATOR receiver
HFP99_12065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_12070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_12090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFP99_12095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP99_12100	COG1151	hydroxylamine reductase activity
HFP99_12105	COG0783	Belongs to the Dps family
HFP99_12130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFP99_12145	COG0300	oxidoreductase activity
HFP99_12155	COG0415	Belongs to the DNA photolyase family
HFP99_12160	COG0789	Transcriptional regulator
HFP99_12165	COG3272	Protein of unknown function (DUF1722)
HFP99_12190	COG0077	Prephenate dehydratase
HFP99_12190	COG1605	Chorismate mutase
HFP99_12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_12230	COG0457	Tetratricopeptide repeat
HFP99_12255	COG2133	pyrroloquinoline quinone binding
HFP99_12265	COG1349	DNA-binding transcription factor activity
HFP99_12270	COG2084	Dehydrogenase
HFP99_12275	COG3395	kinase activity
HFP99_12280	COG0235	Class ii aldolase
HFP99_12285	COG3622	Belongs to the hyi family
HFP99_12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFP99_12295	COG2610	gluconate transmembrane transporter activity
HFP99_12305	COG0840	transmembrane signaling receptor activity
HFP99_12315	COG0300	oxidoreductase activity
HFP99_12340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFP99_12360	COG3813	Protein conserved in bacteria
HFP99_12370	COG0826	peptidase U32
HFP99_12375	COG1280	lysine exporter protein (LysE YggA)
HFP99_12410	COG2205	protein histidine kinase activity
HFP99_12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_12415	COG2197	response regulator
HFP99_12440	COG2200	EAL domain
HFP99_12440	COG2199	diguanylate cyclase activity
HFP99_12440	COG2203	Gaf domain
HFP99_12485	COG1566	PFAM secretion protein HlyD family protein
HFP99_12495	COG0114	fumarate hydratase activity
HFP99_12505	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFP99_12505	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFP99_12505	COG0506	proline dehydrogenase activity
HFP99_12510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFP99_12525	COG0737	Belongs to the 5'-nucleotidase family
HFP99_12545	COG2204	response regulator
HFP99_12550	COG0545	Peptidyl-prolyl cis-trans isomerase
HFP99_12565	COG1047	Peptidyl-prolyl cis-trans
HFP99_12570	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFP99_12580	COG0784	Response regulator, receiver
HFP99_12580	COG0835	chemotaxis
HFP99_12585	COG0429	hydrolase of the alpha beta-hydrolase fold
HFP99_12590	COG2203	Gaf domain
HFP99_12590	COG5001	Diguanylate cyclase
HFP99_12590	COG3706	GGDEF domain
HFP99_12590	COG4251	negative regulation of phosphorylation
HFP99_12595	COG3089	Belongs to the UPF0270 family
HFP99_12600	COG3954	Phosphoribulokinase
HFP99_12615	COG1765	OsmC-like protein
HFP99_12635	COG2205	protein histidine kinase activity
HFP99_12640	COG2814	Major facilitator Superfamily
HFP99_12665	COG0748	coenzyme F420 binding
HFP99_12670	COG3721	Heme iron utilization protein
HFP99_12680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP99_12705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HFP99_12715	COG0463	Glycosyl transferase, family 2
HFP99_12720	COG0741	lytic transglycosylase activity
HFP99_12725	COG0488	(ABC) transporter
HFP99_12735	COG2252	PERMEase
HFP99_12740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HFP99_12745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFP99_12750	COG3178	'Phosphotransferase
HFP99_12755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HFP99_12765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HFP99_12770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFP99_12775	COG2967	ApaG domain
HFP99_12780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFP99_12790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP99_12795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HFP99_12805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFP99_12810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HFP99_12815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HFP99_12820	COG0142	geranyltranstransferase activity
HFP99_12825	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HFP99_12830	COG0330	HflC and HflK could
HFP99_12835	COG0330	HflC and HflK could
HFP99_12840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFP99_12845	COG1923	regulation of RNA biosynthetic process
HFP99_12850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFP99_12855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFP99_12865	COG0802	atpase or kinase
HFP99_12870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFP99_12870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFP99_12890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFP99_12895	COG2011	ABC-type metal ion transport system permease component
HFP99_12900	COG1464	Belongs to the NlpA lipoprotein family
HFP99_12910	COG0840	transmembrane signaling receptor activity
HFP99_12930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HFP99_12935	COG0784	Response regulator, receiver
HFP99_12935	COG2198	Histidine kinase
HFP99_12935	COG5002	protein histidine kinase activity
HFP99_12970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFP99_12975	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HFP99_12985	COG2716	regulation of RNA biosynthetic process
HFP99_12990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_13000	COG3013	Belongs to the UPF0304 family
HFP99_13010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFP99_13015	COG0857	belongs to the CobB CobQ family
HFP99_13015	COG0280	phosphate acetyltransferase
HFP99_13020	COG0440	acetolactate synthase activity
HFP99_13025	COG0028	Belongs to the TPP enzyme family
HFP99_13035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFP99_13040	COG0671	phosphoesterase, PA-phosphatase related
HFP99_13050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFP99_13055	COG0473	3-isopropylmalate dehydrogenase activity
HFP99_13060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HFP99_13065	COG0066	3-isopropylmalate dehydratase activity
HFP99_13080	COG4143	(ABC) transporter
HFP99_13085	COG1178	ABC-type Fe3 transport system permease component
HFP99_13090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HFP99_13095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HFP99_13135	COG0316	Belongs to the HesB IscA family
HFP99_13145	COG0038	chloride channel
HFP99_13150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFP99_13165	COG0671	phosphoesterase, PA-phosphatase related
HFP99_13180	COG2076	Multidrug Resistance protein
HFP99_13190	COG0346	lactoylglutathione lyase activity
HFP99_13195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFP99_13200	COG1643	Atp-dependent helicase
HFP99_13210	COG1489	DNA binding
HFP99_13215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFP99_13220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFP99_13225	COG0617	tRNA 3'-terminal CCA addition
HFP99_13230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFP99_13235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HFP99_13240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HFP99_13250	COG0842	Transport permease protein
HFP99_13255	COG1131	(ABC) transporter
HFP99_13270	COG0163	prenyltransferase activity
HFP99_13275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFP99_13280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HFP99_13295	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HFP99_13310	COG1136	(ABC) transporter
HFP99_13340	COG0529	Catalyzes the synthesis of activated sulfate
HFP99_13345	COG3273	potassium ion transport
HFP99_13345	COG0471	metal ion transport
HFP99_13350	COG2895	sulfate adenylyltransferase (ATP) activity
HFP99_13355	COG0175	sulfate reduction
HFP99_13360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFP99_13360	COG1648	precorrin-2 dehydrogenase activity
HFP99_13365	COG0330	HflC and HflK could
HFP99_13370	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFP99_13380	COG0673	inositol 2-dehydrogenase activity
HFP99_13390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFP99_13395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFP99_13400	COG3036	rescue of stalled ribosome
HFP99_13415	COG0138	bifunctional purine biosynthesis protein purh
HFP99_13420	COG0151	Belongs to the GarS family
HFP99_13450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFP99_13460	COG1610	YqeY-like protein
HFP99_13465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HFP99_13470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HFP99_13480	COG1388	LysM domain
HFP99_13480	COG4942	peptidase
HFP99_13490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFP99_13495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HFP99_13500	COG0585	pseudouridine synthase activity
HFP99_13510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HFP99_13515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HFP99_13520	COG0148	phosphopyruvate hydratase activity
HFP99_13525	COG0504	CTP synthase activity
HFP99_13530	COG3956	TIGRFAM MazG family protein
HFP99_13535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFP99_13540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFP99_13550	COG4807	Protein conserved in bacteria
HFP99_13555	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFP99_13560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFP99_13565	COG1381	Involved in DNA repair and RecF pathway recombination
HFP99_13575	COG0571	ribonuclease III activity
HFP99_13580	COG0681	Belongs to the peptidase S26 family
HFP99_13585	COG0481	GTPase activity
HFP99_13605	COG1595	DNA-templated transcription, initiation
HFP99_13610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFP99_13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP99_13665	COG0191	fructose-bisphosphate aldolase activity
HFP99_13670	COG0126	phosphoglycerate kinase activity
HFP99_13675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFP99_13680	COG1940	carbohydrate kinase activity
HFP99_13685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HFP99_13695	COG4991	sh3 domain protein
HFP99_13700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFP99_13715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HFP99_13725	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_13735	COG1505	serine-type exopeptidase activity
HFP99_13740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFP99_13745	COG0765	amino acid transport
HFP99_13750	COG0765	amino acid transport
HFP99_13760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_13765	COG3174	membrane
HFP99_13770	COG0110	maltose O-acetyltransferase activity
HFP99_13795	COG1942	4-Oxalocrotonate Tautomerase
HFP99_13805	COG0583	DNA-binding transcription factor activity
HFP99_13810	COG0165	Argininosuccinate lyase
HFP99_13815	COG0137	argininosuccinate synthase activity
HFP99_13825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFP99_13830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HFP99_13840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HFP99_13845	COG3447	MASE1 domain protein
HFP99_13845	COG5001	Diguanylate cyclase
HFP99_13845	COG5002	protein histidine kinase activity
HFP99_13880	COG0583	DNA-binding transcription factor activity
HFP99_13885	COG1380	Effector of murein hydrolase LrgA
HFP99_13890	COG1346	cytolysis
HFP99_13895	COG0527	aspartate kinase activity
HFP99_13895	COG0460	homoserine dehydrogenase
HFP99_13900	COG0626	cystathionine gamma-synthase activity
HFP99_13915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP99_13920	COG0814	amino acid
HFP99_13925	COG1218	3'(2'),5'-bisphosphate nucleotidase
HFP99_13930	COG0494	nUDIX hydrolase
HFP99_13935	COG1011	Hydrolase
HFP99_13940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFP99_13955	COG1486	melibiose metabolic process
HFP99_13960	COG2169	Transcriptional regulator
HFP99_13960	COG1917	Cupin 2, conserved barrel domain protein
HFP99_13965	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFP99_13970	COG2723	6-phospho-beta-galactosidase activity
HFP99_13975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_13980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_13990	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HFP99_14000	COG3156	type II secretion system protein K
HFP99_14010	COG4795	General secretion pathway protein
HFP99_14015	COG2165	general secretion pathway protein
HFP99_14025	COG2165	general secretion pathway protein
HFP99_14030	COG1459	type II secretion system
HFP99_14035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFP99_14040	COG1450	Type ii and iii secretion system protein
HFP99_14045	COG3031	protein transport across the cell outer membrane
HFP99_14055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFP99_14060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HFP99_14080	COG3133	Outer membrane lipoprotein
HFP99_14085	COG3025	triphosphatase activity
HFP99_14090	COG1392	Phosphate transport regulator
HFP99_14095	COG0306	phosphate transporter
HFP99_14100	COG0617	tRNA 3'-terminal CCA addition
HFP99_14105	COG3267	Type II secretory pathway component ExeA
HFP99_14105	COG3409	Peptidoglycan-binding domain 1 protein
HFP99_14120	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HFP99_14135	COG3240	lipase activity
HFP99_14145	COG3009	Protein conserved in bacteria
HFP99_14150	COG3008	intermembrane lipid transfer
HFP99_14150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFP99_14155	COG2995	paraquat-inducible protein a
HFP99_14165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP99_14170	COG2203	Gaf domain
HFP99_14170	COG4251	negative regulation of phosphorylation
HFP99_14170	COG3706	GGDEF domain
HFP99_14170	COG5001	Diguanylate cyclase
HFP99_14175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFP99_14180	COG2813	Specifically methylates the guanine in position
HFP99_14185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFP99_14190	COG0297	glycogen (starch) synthase activity
HFP99_14230	COG1757	Na H antiporter
HFP99_14235	COG0583	DNA-binding transcription factor activity
HFP99_14240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HFP99_14245	COG3842	ATPase activity
HFP99_14250	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFP99_14255	COG1177	transmembrane transport
HFP99_14260	COG1012	belongs to the aldehyde dehydrogenase family
HFP99_14265	COG0109	protoheme IX farnesyltransferase activity
HFP99_14270	COG1612	heme a metabolic process
HFP99_14295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HFP99_14305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFP99_14310	COG1444	tRNA N-acetyltransferase activity
HFP99_14330	COG1803	Methylglyoxal synthase
HFP99_14345	COG0252	asparaginase activity
HFP99_14355	COG1609	Transcriptional regulator
HFP99_14365	COG1940	carbohydrate kinase activity
HFP99_14370	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFP99_14375	COG2723	6-phospho-beta-galactosidase activity
HFP99_14380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_14380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_14385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_14390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFP99_14405	COG1609	Transcriptional regulator
HFP99_14410	COG1263	PTS System
HFP99_14410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFP99_14415	COG0366	Alpha amylase catalytic
HFP99_14420	COG0110	maltose O-acetyltransferase activity
HFP99_14425	COG1522	sequence-specific DNA binding
HFP99_14430	COG5006	permease, DMT superfamily
HFP99_14475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HFP99_14480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFP99_14495	COG0477	Major facilitator Superfamily
HFP99_14500	COG0523	cobalamin synthesis protein
HFP99_14510	COG1280	lysine exporter protein (LysE YggA)
HFP99_14520	COG0583	DNA-binding transcription factor activity
HFP99_14525	COG1028	Short-chain dehydrogenase reductase Sdr
HFP99_14530	COG2200	EAL domain
HFP99_14535	COG2200	EAL domain
HFP99_14540	COG1049	propionate catabolic process, 2-methylcitrate cycle
HFP99_14550	COG0840	transmembrane signaling receptor activity
HFP99_14555	COG0840	transmembrane signaling receptor activity
HFP99_14570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFP99_14575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP99_14580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HFP99_14585	COG2186	Transcriptional regulator
HFP99_14610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFP99_14615	COG1459	type II secretion system
HFP99_14630	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HFP99_14635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HFP99_14640	COG0494	nUDIX hydrolase
HFP99_14645	COG0653	protein targeting
HFP99_14655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HFP99_14660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFP99_14665	COG0849	cell division
HFP99_14670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFP99_14675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFP99_14680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFP99_14685	COG0772	Belongs to the SEDS family
HFP99_14690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFP99_14695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFP99_14700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFP99_14710	COG0768	penicillin binding
HFP99_14715	COG3116	cell division
HFP99_14720	COG0275	rRNA processing
HFP99_14725	COG2001	Belongs to the MraZ family
HFP99_14735	COG1388	LysM domain
HFP99_14735	COG0741	lytic transglycosylase activity
HFP99_14745	COG1360	Flagellar Motor Protein
HFP99_14750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HFP99_14755	COG1191	sigma factor activity
HFP99_14780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HFP99_14785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HFP99_14790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HFP99_14805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HFP99_14810	COG1256	bacterial-type flagellum assembly
HFP99_14810	COG4786	Flagellar basal body rod
HFP99_14820	COG1706	bacterial-type flagellum-dependent cell motility
HFP99_14825	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HFP99_14830	COG4786	Flagellar basal body rod
HFP99_14840	COG1749	Flagellar hook protein flgE
HFP99_14855	COG1815	bacterial-type flagellum-dependent cell motility
HFP99_14865	COG2747	anti-sigma28 factor FlgM
HFP99_14890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HFP99_14900	COG1677	Flagellar hook-basal body complex protein FliE
HFP99_14925	COG1987	bacterial-type flagellum assembly
HFP99_14950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFP99_14955	COG3107	peptidoglycan biosynthetic process
HFP99_14960	COG0792	nuclease activity
HFP99_14965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HFP99_14970	COG2823	Periplasmic or secreted lipoprotein
HFP99_14975	COG2969	positive regulation of protein catabolic process
HFP99_14980	COG0625	glutathione transferase activity
HFP99_14985	COG2857	Cytochrome c1
HFP99_14990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HFP99_14995	COG0723	plastoquinol--plastocyanin reductase activity
HFP99_15000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFP99_15005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HFP99_15010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFP99_15020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFP99_15025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFP99_15055	COG3964	amidohydrolase
HFP99_15070	COG3711	transcriptional antiterminator
HFP99_15070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_15075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_15080	COG1660	Displays ATPase and GTPase activities
HFP99_15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_15100	COG1137	ATPase activity
HFP99_15105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFP99_15110	COG3117	lipopolysaccharide transmembrane transporter activity
HFP99_15115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFP99_15120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFP99_15120	COG0517	IMP dehydrogenase activity
HFP99_15125	COG1127	ABC transporter
HFP99_15130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP99_15135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFP99_15140	COG2854	intermembrane phospholipid transfer
HFP99_15150	COG5007	Belongs to the BolA IbaG family
HFP99_15155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFP99_15165	COG0312	modulator of DNA gyrase
HFP99_15170	COG3028	Belongs to the UPF0307 family
HFP99_15180	COG2926	Belongs to the UPF0265 family
HFP99_15210	COG1396	sequence-specific DNA binding
HFP99_15215	COG3135	benzoate transporter
HFP99_15245	COG3047	cAMP biosynthetic process
HFP99_15250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFP99_15255	COG2197	response regulator
HFP99_15275	COG1278	Cold shock
HFP99_15280	COG4771	TonB-dependent receptor
HFP99_15285	COG2205	protein histidine kinase activity
HFP99_15290	COG0745	RESPONSE REGULATOR receiver
HFP99_15310	COG3706	GGDEF domain
HFP99_15315	COG0347	Belongs to the P(II) protein family
HFP99_15320	COG0004	ammonium transporteR
HFP99_15330	COG0346	lactoylglutathione lyase activity
HFP99_15340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFP99_15345	COG1074	ATP-dependent DNA helicase activity
HFP99_15355	COG2259	Doxx family
HFP99_15360	COG1741	Belongs to the pirin family
HFP99_15370	COG0583	DNA-binding transcription factor activity
HFP99_15405	COG3842	ATPase activity
HFP99_15415	COG2199	diguanylate cyclase activity
HFP99_15430	COG2207	Transcriptional regulator
HFP99_15435	COG1247	-acetyltransferase
HFP99_15440	COG0753	catalase activity
HFP99_15460	COG0671	phosphoesterase, PA-phosphatase related
HFP99_15465	COG0628	permease
HFP99_15475	COG2957	Belongs to the agmatine deiminase family
HFP99_15485	COG2957	Belongs to the agmatine deiminase family
HFP99_15490	COG0583	DNA-binding transcription factor activity
HFP99_15495	COG3284	Transcriptional regulator
HFP99_15500	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HFP99_15500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_15500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFP99_15505	COG1461	Dihydroxyacetone kinase
HFP99_15510	COG2376	Dihydroxyacetone kinase
HFP99_15515	COG2252	PERMEase
HFP99_15520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HFP99_15550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HFP99_15555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFP99_15560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HFP99_15565	COG0049	tRNA binding
HFP99_15570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFP99_15575	COG2168	tRNA wobble position uridine thiolation
HFP99_15605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFP99_15610	COG0085	RNA polymerase activity
HFP99_15615	COG0222	ribosome binding
HFP99_15620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HFP99_15625	COG0081	regulation of translation
HFP99_15630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HFP99_15635	COG0250	Participates in transcription elongation, termination and antitermination
HFP99_15650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFP99_15675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFP99_15680	COG0569	domain protein
HFP99_15685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFP99_15695	COG3005	denitrification pathway
HFP99_15700	COG0243	molybdopterin cofactor binding
HFP99_15710	COG2205	protein histidine kinase activity
HFP99_15715	COG0745	RESPONSE REGULATOR receiver
HFP99_15735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFP99_15745	COG2204	response regulator
HFP99_15755	COG2205	protein histidine kinase activity
HFP99_15775	COG0517	IMP dehydrogenase activity
HFP99_15775	COG0516	GMP reductase activity
HFP99_15780	COG5413	integral membrane protein
HFP99_15790	COG1522	sequence-specific DNA binding
HFP99_15795	COG2502	aspartate--ammonia ligase
HFP99_15800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFP99_15800	COG0321	lipoyl(octanoyl) transferase activity
HFP99_15805	COG0542	response to heat
HFP99_15815	COG0564	pseudouridine synthase activity
HFP99_15820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_15835	COG3681	Belongs to the UPF0597 family
HFP99_15840	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HFP99_15845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFP99_15855	COG2207	Transcriptional regulator
HFP99_15860	COG3040	lipid binding
HFP99_15865	COG0840	transmembrane signaling receptor activity
HFP99_15880	COG0540	Belongs to the ATCase OTCase family
HFP99_15885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HFP99_15890	COG1438	arginine binding
HFP99_15895	COG1288	antiporter activity
HFP99_15900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HFP99_15930	COG4211	Belongs to the binding-protein-dependent transport system permease family
HFP99_15945	COG3250	beta-galactosidase activity
HFP99_15950	COG1609	Transcriptional regulator
HFP99_15955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFP99_15965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HFP99_15970	COG2017	converts alpha-aldose to the beta-anomer
HFP99_15975	COG0667	Aldo Keto reductase
HFP99_15980	COG1968	undecaprenyl-diphosphatase activity
HFP99_15985	COG3806	Anti-sigma factor
HFP99_15990	COG1595	DNA-templated transcription, initiation
HFP99_16000	COG0018	arginyl-trna synthetase
HFP99_16010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HFP99_16015	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HFP99_16020	COG0477	Major facilitator Superfamily
HFP99_16035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_16040	COG1131	(ABC) transporter
HFP99_16045	COG0842	Transport permease protein
HFP99_16050	COG0842	Transport permease protein
HFP99_16055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP99_16065	COG2116	formate transmembrane transporter activity
HFP99_16070	COG1648	precorrin-2 dehydrogenase activity
HFP99_16070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFP99_16075	COG2239	Acts as a magnesium transporter
HFP99_16080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFP99_16085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HFP99_16095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFP99_16105	COG0514	ATP-dependent DNA helicase (RecQ)
HFP99_16110	COG2050	protein possibly involved in aromatic compounds catabolism
HFP99_16125	COG2258	MOSC domain
HFP99_16130	COG1177	transmembrane transport
HFP99_16135	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFP99_16140	COG3842	ATPase activity
HFP99_16160	COG0174	glutamine synthetase
HFP99_16180	COG3045	CreA protein
HFP99_16185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFP99_16190	COG0443	Heat shock 70 kDa protein
HFP99_16205	COG0366	Alpha amylase catalytic
HFP99_16215	COG4310	Domain of unknown function (DUF2172)
HFP99_16250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFP99_16255	COG0745	RESPONSE REGULATOR receiver
HFP99_16265	COG2205	protein histidine kinase activity
HFP99_16275	COG0281	malic enzyme
HFP99_16280	COG0702	epimerase
HFP99_16285	COG0254	rRNA binding
HFP99_16290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFP99_16295	COG2885	chlorophyll binding
HFP99_16295	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFP99_16305	COG0129	dihydroxy-acid dehydratase activity
HFP99_16315	COG3978	acetolactate synthase activity
HFP99_16325	COG0606	chelatase, subunit chli
HFP99_16330	COG0204	Acyl-transferase
HFP99_16335	COG0204	Acyl-transferase
HFP99_16340	COG1683	Conserved Protein
HFP99_16350	COG1335	isochorismatase
HFP99_16360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HFP99_16365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFP99_16370	COG3639	organic phosphonate transmembrane transporter activity
HFP99_16375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFP99_16380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFP99_16390	COG3084	Protein conserved in bacteria
HFP99_16395	COG5001	Diguanylate cyclase
HFP99_16395	COG3706	GGDEF domain
HFP99_16395	COG2203	Gaf domain
HFP99_16395	COG4251	negative regulation of phosphorylation
HFP99_16400	COG0789	Transcriptional regulator
HFP99_16410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HFP99_16415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HFP99_16420	COG1561	YicC-like family, N-terminal region
HFP99_16430	COG1519	Transferase
HFP99_16435	COG0859	PFAM glycosyl transferase family 9
HFP99_16440	COG0463	Glycosyl transferase, family 2
HFP99_16445	COG0859	PFAM glycosyl transferase family 9
HFP99_16450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFP99_16455	COG2990	Protein conserved in bacteria
HFP99_16460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFP99_16470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFP99_16475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFP99_16480	COG2003	Belongs to the UPF0758 family
HFP99_16485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFP99_16490	COG0756	dUTP diphosphatase activity
HFP99_16495	COG1309	transcriptional regulator
HFP99_16510	COG0668	transmembrane transport
HFP99_16515	COG0166	Belongs to the GPI family
HFP99_16520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HFP99_16525	COG0583	DNA-binding transcription factor activity
HFP99_16535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP99_16535	COG0045	succinate-CoA ligase (ADP-forming) activity
HFP99_16535	COG1042	CoA-binding domain protein
HFP99_16565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFP99_16570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFP99_16570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFP99_16575	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HFP99_16580	COG3074	FtsZ-dependent cytokinesis
HFP99_16590	COG1045	serine acetyltransferase
HFP99_16600	COG0745	RESPONSE REGULATOR receiver
HFP99_16605	COG2205	protein histidine kinase activity
HFP99_16610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFP99_16615	COG0534	Mate efflux family protein
HFP99_16630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFP99_16635	COG2937	Belongs to the GPAT DAPAT family
HFP99_16640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFP99_16645	COG3161	chorismate lyase activity
HFP99_16650	COG1580	Controls the rotational direction of flagella during chemotaxis
HFP99_16665	COG0604	alcohol dehydrogenase
HFP99_16680	COG1215	transferase activity, transferring glycosyl groups
HFP99_16685	COG3307	-O-antigen
HFP99_16695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFP99_16700	COG1309	transcriptional regulator
HFP99_16710	COG1063	alcohol dehydrogenase
HFP99_16725	COG0210	DNA helicase
HFP99_16730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFP99_16735	COG2166	iron-sulfur cluster assembly
HFP99_16740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFP99_16775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFP99_16780	COG4206	TonB-dependent receptor
HFP99_16785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFP99_16790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFP99_16795	COG2223	nitrite transmembrane transporter activity
HFP99_16800	COG3279	Response regulator of the LytR AlgR family
HFP99_16805	COG3275	phosphorelay sensor kinase activity
HFP99_16815	COG2223	nitrite transmembrane transporter activity
HFP99_16820	COG2081	HI0933 family
HFP99_16825	COG1528	Iron-storage protein
HFP99_16830	COG3706	GGDEF domain
HFP99_16835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFP99_16840	COG0589	response to stress
HFP99_16880	COG3642	lipopolysaccharide core region biosynthetic process
HFP99_16885	COG0859	PFAM glycosyl transferase family 9
HFP99_16900	COG1758	RNA polymerase activity
HFP99_16905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFP99_16910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFP99_16920	COG2267	carboxylic ester hydrolase activity
HFP99_16925	COG0561	phosphatase activity
HFP99_16960	COG1309	transcriptional regulator
HFP99_16965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFP99_16970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP99_16980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFP99_17000	COG2205	protein histidine kinase activity
HFP99_17005	COG0745	RESPONSE REGULATOR receiver
HFP99_17010	COG2814	Major facilitator Superfamily
HFP99_17025	COG3977	Valine--pyruvate aminotransferase
HFP99_17030	COG0071	Belongs to the small heat shock protein (HSP20) family
HFP99_17035	COG0071	Belongs to the small heat shock protein (HSP20) family
HFP99_17040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFP99_17050	COG0187	DNA topoisomerase II activity
HFP99_17060	COG0592	DNA-directed DNA polymerase activity
HFP99_17065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HFP99_17085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HFP99_17090	COG0594	ribonuclease P activity
HFP99_17095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HFP99_17100	COG0706	membrane insertase activity
HFP99_17105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HFP99_17115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFP99_17120	COG1120	ATPase activity
HFP99_17125	COG4615	Cyclic peptide transporter
HFP99_17130	COG4774	siderophore transport
HFP99_17135	COG0716	FMN binding
HFP99_17140	COG0445	tRNA wobble uridine modification
HFP99_17145	COG0357	Ribosomal RNA small subunit methyltransferase G
HFP99_17150	COG1192	Involved in chromosome partitioning
HFP99_17155	COG1475	DNA binding
HFP99_17165	COG0356	it plays a direct role in the translocation of protons across the membrane
HFP99_17175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFP99_17180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFP99_17185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFP99_17190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFP99_17195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFP99_17200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HFP99_17205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFP99_17210	COG4452	Inner membrane protein CreD
HFP99_17220	COG2205	protein histidine kinase activity
HFP99_17225	COG0745	RESPONSE REGULATOR receiver
HFP99_17230	COG1349	DNA-binding transcription factor activity
HFP99_17240	COG2771	luxR family
HFP99_17250	COG0811	peptide transport
HFP99_17255	COG0811	peptide transport
HFP99_17260	COG0848	biopolymer transport protein
HFP99_17265	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HFP99_17310	COG0402	S-adenosylhomocysteine deaminase activity
HFP99_17315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFP99_17325	COG3165	ubiquinone biosynthetic process from chorismate
HFP99_17330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HFP99_17335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFP99_17340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFP99_17345	COG0805	protein transport
HFP99_17350	COG0084	hydrolase, TatD family'
HFP99_17370	COG0742	ribosomal rna small subunit methyltransferase
HFP99_17385	COG0248	Ppx GppA phosphatase
HFP99_17390	COG0513	Belongs to the DEAD box helicase family
HFP99_17395	COG3118	belongs to the thioredoxin family
HFP99_17410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HFP99_17420	COG2960	long-chain fatty acid transporting porin activity
HFP99_17435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP99_17475	COG1609	Transcriptional regulator
HFP99_17480	COG3604	Transcriptional regulator
HFP99_17485	COG1773	rubredoxin
HFP99_17485	COG0426	domain, Protein
HFP99_17490	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP99_17500	COG0348	domain, Protein
HFP99_17510	COG3033	Beta-eliminating lyase
HFP99_17515	COG0814	amino acid
HFP99_17520	COG0814	amino acid
HFP99_17550	COG0751	glycine-tRNA ligase activity
HFP99_17555	COG0752	glycyl-tRNA synthetase alpha subunit
HFP99_17560	COG2818	Glycosylase
HFP99_17565	COG1335	isochorismatase
HFP99_17585	COG2885	chlorophyll binding
HFP99_17590	COG0251	oxidation-reduction process
HFP99_17595	COG0425	Belongs to the sulfur carrier protein TusA family
HFP99_17620	COG0745	RESPONSE REGULATOR receiver
HFP99_17625	COG0183	Belongs to the thiolase family
HFP99_17630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP99_17630	COG1024	Enoyl-CoA hydratase
HFP99_17635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP99_17640	COG0006	proline dipeptidase activity
HFP99_17645	COG1739	Uncharacterized protein family UPF0029
HFP99_17650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFP99_17655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HFP99_17690	COG1609	Transcriptional regulator
HFP99_17695	COG3250	beta-galactosidase activity
HFP99_17700	COG2731	YhcH YjgK YiaL family protein
HFP99_17705	COG0531	amino acid
HFP99_17710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP99_17715	COG0531	amino acid
HFP99_17720	COG0385	Bile acid
HFP99_17750	COG0583	DNA-binding transcription factor activity
HFP99_17760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFP99_17785	COG0583	DNA-binding transcription factor activity
HFP99_17820	COG0210	DNA helicase
HFP99_17835	COG1943	Transposase
HFP99_17840	COG0583	DNA-binding transcription factor activity
HFP99_17860	COG2823	Periplasmic or secreted lipoprotein
HFP99_17875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFP99_17910	COG0583	DNA-binding transcription factor activity
HFP99_17915	COG1280	lysine exporter protein (LysE YggA)
HFP99_17920	COG2391	methyltransferase activity
HFP99_17925	COG1280	lysine exporter protein (LysE YggA)
HFP99_17935	COG2962	Rard protein
HFP99_17945	COG1012	belongs to the aldehyde dehydrogenase family
HFP99_17950	COG1396	sequence-specific DNA binding
HFP99_17965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFP99_17965	COG0519	Catalyzes the synthesis of GMP from XMP
HFP99_17975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP99_17995	COG1322	Protein conserved in bacteria
HFP99_18000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFP99_18005	COG0569	domain protein
HFP99_18010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFP99_18010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFP99_18015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HFP99_18020	COG0242	peptide deformylase activity
HFP99_18030	COG0758	DNA mediated transformation
HFP99_18035	COG2922	Belongs to the Smg family
HFP99_18040	COG0551	DNA topoisomerase type I activity
HFP99_18045	COG0009	L-threonylcarbamoyladenylate synthase
HFP99_18050	COG0408	coproporphyrinogen oxidase activity
HFP99_18055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFP99_18060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HFP99_18070	COG3078	GTPase activator activity
HFP99_18080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFP99_18085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFP99_18095	COG3852	Histidine kinase
HFP99_18105	COG0174	glutamine synthetase
HFP99_18115	COG1295	ribonuclease BN
HFP99_18120	COG1490	D-aminoacyl-tRNA deacylase activity
HFP99_18130	COG0456	acetyltransferase
HFP99_18140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFP99_18145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFP99_18150	COG2610	gluconate transmembrane transporter activity
HFP99_18155	COG3265	gluconokinase activity
HFP99_18160	COG0129	dihydroxy-acid dehydratase activity
HFP99_18165	COG0800	Aldolase
HFP99_18180	COG1609	Transcriptional regulator
HFP99_18190	COG4942	peptidase
HFP99_18195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFP99_18200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP99_18205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HFP99_18210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFP99_18215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HFP99_18215	COG0316	Belongs to the HesB IscA family
HFP99_18220	COG1040	competence protein
HFP99_18225	COG0596	Alpha beta hydrolase
HFP99_18240	COG2183	response to ionizing radiation
HFP99_18245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFP99_18250	COG0745	RESPONSE REGULATOR receiver
HFP99_18255	COG2205	protein histidine kinase activity
HFP99_18265	COG0051	transcription antitermination factor activity, RNA binding
HFP99_18270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HFP99_18275	COG0088	Forms part of the polypeptide exit tunnel
HFP99_18280	COG0089	rRNA binding
HFP99_18285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFP99_18290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFP99_18295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HFP99_18300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFP99_18305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HFP99_18310	COG0255	Belongs to the universal ribosomal protein uL29 family
HFP99_18315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HFP99_18320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFP99_18325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFP99_18330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFP99_18335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFP99_18340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HFP99_18345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFP99_18350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HFP99_18355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFP99_18360	COG1841	ribosomal large subunit assembly
HFP99_18365	COG0200	Binds to the 23S rRNA
HFP99_18370	COG0201	protein transport
HFP99_18375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFP99_18380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFP99_18385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HFP99_18390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HFP99_18395	COG0202	RNA polymerase activity
HFP99_18400	COG0203	ribosomal protein L17
HFP99_18450	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFP99_18455	COG0583	DNA-binding transcription factor activity
HFP99_18460	COG4221	oxidoreductase activity
HFP99_18475	COG1770	oligopeptidase
HFP99_18495	COG3714	YhhN family
HFP99_18520	COG1301	dicarboxylic acid transport
HFP99_18530	COG2095	MarC family integral membrane protein
HFP99_18540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFP99_18550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HFP99_18560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFP99_18585	COG0742	ribosomal rna small subunit methyltransferase
HFP99_18590	COG0552	protein localization to endoplasmic reticulum
HFP99_18595	COG2884	Cell division ATP-binding protein ftsE
HFP99_18600	COG2177	Part of the ABC transporter FtsEX involved in
HFP99_18610	COG0288	reversible hydration of carbon dioxide
HFP99_18615	COG2188	Transcriptional regulator
HFP99_18620	COG1228	amidohydrolase
HFP99_18625	COG0010	Belongs to the arginase family
HFP99_18630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HFP99_18635	COG2986	histidine ammonia-lyase
HFP99_18640	COG0387	Pfam Sodium calcium exchanger
HFP99_18645	COG2200	EAL domain
HFP99_18700	COG1459	type II secretion system
HFP99_18745	COG1077	Cell shape determining protein MreB Mrl
HFP99_18750	COG1792	Involved in formation and maintenance of cell shape
HFP99_18755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFP99_18760	COG0424	maF-like protein
HFP99_18765	COG1530	ribonuclease E activity
HFP99_18770	COG3164	Protein of unknown function
HFP99_18775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFP99_18780	COG0312	modulator of DNA gyrase
HFP99_18795	COG0477	Major facilitator Superfamily
HFP99_18805	COG2321	neutral zinc metallopeptidase
HFP99_18825	COG1715	Restriction endonuclease
HFP99_18830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HFP99_18835	COG0732	type I restriction modification DNA specificity domain
HFP99_18850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HFP99_18855	COG3171	Protein conserved in bacteria
HFP99_18885	COG0582	viral genome integration into host DNA
HFP99_18910	COG0189	ligase activity
HFP99_18940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HFP99_18945	COG0352	thiamine-phosphate diphosphorylase activity
HFP99_18950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFP99_18960	COG2022	thiamine diphosphate biosynthetic process
HFP99_18965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HFP99_18970	COG1943	Transposase
HFP99_18990	COG2203	Gaf domain
HFP99_18990	COG2199	diguanylate cyclase activity
HFP99_18995	COG3932	Exopolysaccharide synthesis, ExoD
HFP99_19015	COG1733	regulation of RNA biosynthetic process
HFP99_19035	COG0456	acetyltransferase
HFP99_19035	COG0454	-acetyltransferase
HFP99_19045	COG1494	fructose-1,6-bisphosphatase
HFP99_19055	COG3071	HemY protein
HFP99_19060	COG2959	enzyme of heme biosynthesis
HFP99_19070	COG0181	hydroxymethylbilane synthase activity
HFP99_19075	COG3072	Adenylate cyclase
HFP99_19080	COG0400	carboxylic ester hydrolase activity
HFP99_19085	COG1965	Belongs to the frataxin family
HFP99_19095	COG0019	diaminopimelate decarboxylase activity
HFP99_19100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HFP99_19115	COG1011	Hydrolase
HFP99_19135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HFP99_19140	COG0561	phosphatase activity
HFP99_19150	COG1988	membrane-bound metal-dependent
HFP99_19155	COG1546	Belongs to the CinA family
HFP99_19155	COG1058	Belongs to the CinA family
HFP99_19165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HFP99_19175	COG1522	sequence-specific DNA binding
HFP99_19180	COG1368	sulfuric ester hydrolase activity
HFP99_19195	COG1285	pathogenesis
HFP99_19215	COG4221	oxidoreductase activity
HFP99_19230	COG1979	alcohol dehydrogenase
HFP99_19265	COG5380	lipid catabolic process
HFP99_19270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HFP99_19280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFP99_19285	COG2949	membrane
HFP99_19290	COG0318	PFAM AMP-dependent synthetase and ligase
HFP99_19295	COG1441	menaquinone biosynthetic process
HFP99_19300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFP99_19305	COG0596	Alpha beta hydrolase
HFP99_19310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HFP99_19315	COG1169	isochorismate synthase
HFP99_19320	COG1575	Belongs to the MenA family. Type 1 subfamily
HFP99_19325	COG1966	Carbon starvation protein
HFP99_19330	COG2879	small protein
HFP99_19335	COG0523	cobalamin synthesis protein
HFP99_19360	COG0513	Belongs to the DEAD box helicase family
HFP99_19365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFP99_19370	COG5492	domain, Protein
HFP99_19370	COG4932	domain protein
HFP99_19375	COG1671	Belongs to the UPF0178 family
HFP99_19400	COG3722	fumarate hydratase activity
HFP99_19405	COG0246	Mannitol dehydrogenase
HFP99_19410	COG2213	PTS system mannitol-specific
HFP99_19410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFP99_19415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HFP99_19430	COG2771	luxR family
HFP99_19445	COG1560	Kdo2-lipid A biosynthetic process
HFP99_19450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HFP99_19450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HFP99_19455	COG1538	Outer membrane efflux protein
HFP99_19460	COG0494	nUDIX hydrolase
HFP99_19465	COG3151	Protein conserved in bacteria
HFP99_19475	COG3150	esterase
HFP99_19480	COG1051	belongs to the nudix hydrolase family
HFP99_19490	COG1566	PFAM secretion protein HlyD family protein
HFP99_19495	COG1289	transmembrane transporter activity
HFP99_19525	COG0456	acetyltransferase
HFP99_19570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP99_19590	COG0204	Acyl-transferase
HFP99_19595	COG1842	Phage shock protein A
HFP99_19610	COG2827	Endonuclease containing a URI domain
HFP99_19615	COG2962	Rard protein
HFP99_19620	COG1573	uracil-dna glycosylase
HFP99_19630	COG0583	DNA-binding transcription factor activity
HFP99_19635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFP99_19640	COG1121	(ABC) transporter
HFP99_19645	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HFP99_19665	COG0739	heme binding
HFP99_19710	COG1546	Belongs to the CinA family
HFP99_19715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFP99_19720	COG2137	regulation of response to DNA damage stimulus
HFP99_19725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFP99_19730	COG0527	aspartate kinase activity
HFP99_19735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HFP99_19770	COG1686	Belongs to the peptidase S11 family
HFP99_19775	COG0586	Pfam SNARE associated Golgi protein
HFP99_19780	COG1253	flavin adenine dinucleotide binding
HFP99_19795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFP99_19800	COG0795	lipopolysaccharide-transporting ATPase activity
HFP99_19805	COG0795	lipopolysaccharide-transporting ATPase activity
HFP99_19825	COG0004	ammonium transporteR
HFP99_19830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFP99_19845	COG0084	hydrolase, TatD family'
HFP99_19850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFP99_19860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFP99_19865	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HFP99_19870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HFP99_19875	COG0813	purine-nucleoside phosphorylase activity
HFP99_19885	COG3064	Membrane
HFP99_19895	COG0560	Phosphoserine phosphatase
HFP99_19910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HFP99_19920	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HFP99_19925	COG0776	regulation of translation
HFP99_19940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFP99_19945	COG0735	belongs to the Fur family
HFP99_19965	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HFP99_19970	COG0513	Belongs to the DEAD box helicase family
HFP99_19975	COG3022	response to hydroperoxide
HFP99_19990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFP99_19995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFP99_20000	COG0762	integral membrane protein
HFP99_20005	COG1872	DUF167
HFP99_20025	COG3112	Uncharacterised protein family (UPF0231)
HFP99_20035	COG3835	regulator
HFP99_20040	COG2610	gluconate transmembrane transporter activity
HFP99_20045	COG1929	Belongs to the glycerate kinase type-1 family
HFP99_20060	COG0583	DNA-binding transcription factor activity
HFP99_20065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFP99_20085	COG0347	Belongs to the P(II) protein family
HFP99_20110	COG3842	ATPase activity
HFP99_20115	COG2837	iron assimilation
HFP99_20120	COG1438	arginine binding
HFP99_20125	COG1126	abc transporter atp-binding protein
HFP99_20130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP99_20135	COG4215	(ABC) transporter
HFP99_20140	COG4160	amino acid transport
HFP99_20145	COG0039	L-malate dehydrogenase activity
HFP99_20150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HFP99_20155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP99_20155	COG1017	nitric oxide dioxygenase activity
HFP99_20165	COG4536	flavin adenine dinucleotide binding
HFP99_20170	COG4137	Cytochrome C assembly protein
HFP99_20175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFP99_20180	COG0228	four-way junction DNA binding
HFP99_20185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFP99_20190	COG0336	Belongs to the RNA methyltransferase TrmD family
HFP99_20195	COG0335	large ribosomal subunit rRNA binding
HFP99_20210	COG1051	belongs to the nudix hydrolase family
HFP99_20220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFP99_20225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HFP99_20230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFP99_20240	COG0583	DNA-binding transcription factor activity
HFP99_20245	COG0640	Transcriptional regulator
HFP99_20250	COG0268	Binds directly to 16S ribosomal RNA
HFP99_20255	COG0728	peptidoglycan biosynthetic process
HFP99_20260	COG0196	riboflavin kinase activity
HFP99_20265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFP99_20270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFP99_20275	COG1047	Peptidyl-prolyl cis-trans
HFP99_20280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HFP99_20340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFP99_20340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HFP99_20355	COG1854	S-ribosylhomocysteine lyase activity
HFP99_20360	COG3706	GGDEF domain
HFP99_20365	COG0557	exoribonuclease II activity
HFP99_20370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFP99_20380	COG2153	protein acetylation
HFP99_20395	COG1914	H( )-stimulated, divalent metal cation uptake system
HFP99_20400	COG0360	Binds together with S18 to 16S ribosomal RNA
HFP99_20405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFP99_20410	COG0359	binds to the 23S rRNA
HFP99_20450	COG1238	metal cluster binding
HFP99_20455	COG0612	Peptidase, M16
HFP99_20460	COG2918	glutathione biosynthetic process
HFP99_20465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HFP99_20470	COG1027	Aspartate ammonia-lyase
HFP99_20475	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFP99_20480	COG0534	Mate efflux family protein
HFP99_20485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HFP99_20490	COG0459	protein refolding
HFP99_20515	COG0564	pseudouridine synthase activity
HFP99_20520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFP99_20550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_20560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HFP99_20565	COG4208	sulfate ABC transporter
HFP99_20570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFP99_20575	COG0583	DNA-binding transcription factor activity
HFP99_20580	COG3397	chitin binding
HFP99_20585	COG0840	transmembrane signaling receptor activity
HFP99_20610	COG1328	CTP reductase activity
HFP99_20615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFP99_20630	COG1448	Aminotransferase
HFP99_20665	COG0513	Belongs to the DEAD box helicase family
HFP99_20675	COG0840	transmembrane signaling receptor activity
HFP99_20685	COG4166	transmembrane transport
HFP99_20695	COG0110	maltose O-acetyltransferase activity
HFP99_20705	COG1024	Enoyl-CoA hydratase
HFP99_20720	COG4221	oxidoreductase activity
HFP99_20725	COG0442	prolyl-tRNA aminoacylation
HFP99_20730	COG1199	ATP-dependent helicase activity
HFP99_20730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFP99_20735	COG0442	prolyl-tRNA aminoacylation
HFP99_20740	COG0840	transmembrane signaling receptor activity
HFP99_20745	COG0632	four-way junction helicase activity
HFP99_20750	COG2255	four-way junction helicase activity
HFP99_20755	COG1271	oxidase subunit
HFP99_20760	COG1294	oxidase, subunit
HFP99_20765	COG4890	Cyd operon protein YbgT
HFP99_20770	COG3790	cyd operon protein YbgE
HFP99_20775	COG0824	Thioesterase
HFP99_20780	COG0811	peptide transport
HFP99_20795	COG0823	Involved in the tonB-independent uptake of proteins
HFP99_20800	COG2885	chlorophyll binding
HFP99_20805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HFP99_20870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFP99_20880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFP99_20885	COG1640	4-alpha-glucanotransferase
HFP99_20890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HFP99_20915	COG2130	NADP-dependent
HFP99_20920	COG1846	Transcriptional regulator
HFP99_20950	COG0561	phosphatase activity
HFP99_20970	COG0733	neurotransmitter:sodium symporter activity
HFP99_20985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP99_21000	COG1794	racemase activity, acting on amino acids and derivatives
HFP99_21010	COG1022	Amp-dependent synthetase and ligase
HFP99_21020	COG0456	acetyltransferase
HFP99_21035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HFP99_21040	COG5001	Diguanylate cyclase
HFP99_21040	COG3300	MHYT domain
HFP99_21050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFP99_21065	COG1902	pentaerythritol trinitrate reductase activity
HFP99_21085	COG2957	Belongs to the agmatine deiminase family
HFP99_21115	COG0513	Belongs to the DEAD box helicase family