locus-tag	class	description
U876_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U876_00010	COG0592	DNA-directed DNA polymerase activity
U876_00020	COG0187	DNA topoisomerase II activity
U876_00030	COG2378	regulation of single-species biofilm formation
U876_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
U876_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
U876_00045	COG3977	Valine--pyruvate aminotransferase
U876_00060	COG2814	Major facilitator Superfamily
U876_00065	COG0745	RESPONSE REGULATOR receiver
U876_00070	COG2205	protein histidine kinase activity
U876_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U876_00100	COG4191	Histidine kinase
U876_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_00115	COG1309	transcriptional regulator
U876_00145	COG0469	pyruvate kinase activity
U876_00150	COG2271	Major facilitator Superfamily
U876_00155	COG1840	ABC-type Fe3 transport system, periplasmic component
U876_00175	COG0561	phosphatase activity
U876_00180	COG2267	carboxylic ester hydrolase activity
U876_00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U876_00200	COG1758	RNA polymerase activity
U876_00210	COG0859	PFAM glycosyl transferase family 9
U876_00215	COG3642	lipopolysaccharide core region biosynthetic process
U876_00255	COG0589	response to stress
U876_00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U876_00265	COG2199	diguanylate cyclase activity
U876_00270	COG1528	Iron-storage protein
U876_00275	COG2081	HI0933 family
U876_00280	COG2223	nitrite transmembrane transporter activity
U876_00300	COG3188	usher protein
U876_00320	COG2205	protein histidine kinase activity
U876_00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_00330	COG3275	phosphorelay sensor kinase activity
U876_00335	COG3279	Response regulator of the LytR AlgR family
U876_00340	COG2223	nitrite transmembrane transporter activity
U876_00345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U876_00350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U876_00365	COG0583	DNA-binding transcription factor activity
U876_00370	COG4206	TonB-dependent receptor
U876_00375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U876_00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U876_00415	COG2166	iron-sulfur cluster assembly
U876_00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U876_00425	COG0210	DNA helicase
U876_00435	COG3245	cytochrome
U876_00440	COG1063	alcohol dehydrogenase
U876_00445	COG0156	8-amino-7-oxononanoate synthase activity
U876_00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U876_00470	COG3306	glycosyltransferase involved in LPS biosynthesis
U876_00490	COG1561	YicC-like family, N-terminal region
U876_00495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
U876_00500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
U876_00515	COG0789	Transcriptional regulator
U876_00520	COG3706	GGDEF domain
U876_00520	COG4251	negative regulation of phosphorylation
U876_00520	COG2203	Gaf domain
U876_00520	COG5001	Diguanylate cyclase
U876_00525	COG3084	Protein conserved in bacteria
U876_00535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U876_00540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_00545	COG3639	organic phosphonate transmembrane transporter activity
U876_00550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
U876_00555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
U876_00565	COG1335	isochorismatase
U876_00575	COG1683	Conserved Protein
U876_00580	COG0204	Acyl-transferase
U876_00585	COG0204	Acyl-transferase
U876_00590	COG0606	chelatase, subunit chli
U876_00600	COG3978	acetolactate synthase activity
U876_00605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U876_00610	COG0129	dihydroxy-acid dehydratase activity
U876_00630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U876_00635	COG0254	rRNA binding
U876_00640	COG0702	epimerase
U876_00645	COG0281	malic enzyme
U876_00655	COG2205	protein histidine kinase activity
U876_00660	COG0745	RESPONSE REGULATOR receiver
U876_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_00680	COG0366	Alpha amylase catalytic
U876_00695	COG0443	Heat shock 70 kDa protein
U876_00700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U876_00705	COG3045	CreA protein
U876_00720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U876_00725	COG0174	glutamine synthetase
U876_00745	COG3842	ATPase activity
U876_00750	COG1176	ABC-type spermidine putrescine transport system, permease component I
U876_00755	COG1177	transmembrane transport
U876_00760	COG2258	MOSC domain
U876_00775	COG2050	protein possibly involved in aromatic compounds catabolism
U876_00780	COG0514	ATP-dependent DNA helicase (RecQ)
U876_00790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
U876_00800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
U876_00805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
U876_00815	COG2239	Acts as a magnesium transporter
U876_00820	COG1648	precorrin-2 dehydrogenase activity
U876_00820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_00825	COG2116	formate transmembrane transporter activity
U876_00830	COG2146	nitrite reductase [NAD(P)H] activity
U876_00840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_00855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
U876_00860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
U876_00880	COG1595	DNA-templated transcription, initiation
U876_00885	COG3806	Anti-sigma factor
U876_00890	COG1968	undecaprenyl-diphosphatase activity
U876_00895	COG0667	Aldo Keto reductase
U876_00900	COG2017	converts alpha-aldose to the beta-anomer
U876_00905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
U876_00915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U876_00920	COG1609	Transcriptional regulator
U876_00925	COG3250	beta-galactosidase activity
U876_00945	COG0840	transmembrane signaling receptor activity
U876_00975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U876_00980	COG1288	antiporter activity
U876_00985	COG1438	arginine binding
U876_00990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
U876_00995	COG0540	Belongs to the ATCase OTCase family
U876_01010	COG0688	phosphatidylethanolamine metabolic process
U876_01030	COG1979	alcohol dehydrogenase
U876_01035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
U876_01040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
U876_01050	COG2964	Protein conserved in bacteria
U876_01055	COG3681	Belongs to the UPF0597 family
U876_01065	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_01070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_01075	COG0564	pseudouridine synthase activity
U876_01085	COG0542	response to heat
U876_01090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U876_01095	COG2502	aspartate--ammonia ligase
U876_01100	COG1522	sequence-specific DNA binding
U876_01110	COG5413	integral membrane protein
U876_01135	COG2205	protein histidine kinase activity
U876_01145	COG2204	response regulator
U876_01165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
U876_01180	COG0745	RESPONSE REGULATOR receiver
U876_01185	COG2205	protein histidine kinase activity
U876_01195	COG0243	molybdopterin cofactor binding
U876_01200	COG3005	denitrification pathway
U876_01205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U876_01225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_01230	COG0569	domain protein
U876_01235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U876_01260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U876_01270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U876_01275	COG0250	Participates in transcription elongation, termination and antitermination
U876_01280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
U876_01285	COG0081	regulation of translation
U876_01290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
U876_01295	COG0222	ribosome binding
U876_01300	COG0085	RNA polymerase activity
U876_01305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U876_01315	COG2964	Protein conserved in bacteria
U876_01320	COG0251	oxidation-reduction process
U876_01330	COG2923	Belongs to the DsrF TusC family
U876_01335	COG2168	tRNA wobble position uridine thiolation
U876_01340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
U876_01345	COG0049	tRNA binding
U876_01350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U876_01355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U876_01360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U876_01390	COG2252	PERMEase
U876_01395	COG2376	Dihydroxyacetone kinase
U876_01400	COG1461	Dihydroxyacetone kinase
U876_01415	COG3284	Transcriptional regulator
U876_01425	COG2957	Belongs to the agmatine deiminase family
U876_01430	COG4221	oxidoreductase activity
U876_01435	COG0628	permease
U876_01440	COG0494	nUDIX hydrolase
U876_01465	COG0753	catalase activity
U876_01470	COG1247	-acetyltransferase
U876_01490	COG3706	GGDEF domain
U876_01500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U876_01510	COG1175	transmembrane transport
U876_01535	COG0583	DNA-binding transcription factor activity
U876_01545	COG1741	Belongs to the pirin family
U876_01550	COG2259	Doxx family
U876_01555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
U876_01560	COG1074	ATP-dependent DNA helicase activity
U876_01565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U876_01575	COG0346	lactoylglutathione lyase activity
U876_01605	COG0745	RESPONSE REGULATOR receiver
U876_01610	COG2205	protein histidine kinase activity
U876_01615	COG2203	Gaf domain
U876_01615	COG3706	GGDEF domain
U876_01615	COG4251	negative regulation of phosphorylation
U876_01615	COG5001	Diguanylate cyclase
U876_01620	COG4771	TonB-dependent receptor
U876_01625	COG1278	Cold shock
U876_01650	COG0629	single-stranded DNA binding
U876_01655	COG2197	response regulator
U876_01660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U876_01675	COG3047	cAMP biosynthetic process
U876_01680	COG0840	transmembrane signaling receptor activity
U876_01710	COG3135	benzoate transporter
U876_01715	COG1396	sequence-specific DNA binding
U876_01745	COG2926	Belongs to the UPF0265 family
U876_01755	COG3028	Belongs to the UPF0307 family
U876_01760	COG0312	modulator of DNA gyrase
U876_01765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U876_01770	COG5007	Belongs to the BolA IbaG family
U876_01780	COG2854	intermembrane phospholipid transfer
U876_01785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U876_01790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U876_01795	COG1127	ABC transporter
U876_01800	COG0517	IMP dehydrogenase activity
U876_01800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U876_01805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
U876_01810	COG3117	lipopolysaccharide transmembrane transporter activity
U876_01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
U876_01820	COG1137	ATPase activity
U876_01825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U876_01835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_01840	COG1660	Displays ATPase and GTPase activities
U876_01845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_01850	COG3711	transcriptional antiterminator
U876_01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_01865	COG3964	amidohydrolase
U876_01895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U876_01900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U876_01910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
U876_01915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
U876_01920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U876_01925	COG0723	plastoquinol--plastocyanin reductase activity
U876_01930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U876_01935	COG2857	Cytochrome c1
U876_01940	COG0625	glutathione transferase activity
U876_01945	COG2969	positive regulation of protein catabolic process
U876_01950	COG2823	Periplasmic or secreted lipoprotein
U876_01955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U876_01960	COG0792	nuclease activity
U876_01965	COG3107	peptidoglycan biosynthetic process
U876_01970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U876_01975	COG2001	Belongs to the MraZ family
U876_01980	COG0275	rRNA processing
U876_01985	COG3116	cell division
U876_01990	COG0768	penicillin binding
U876_02000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U876_02005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U876_02010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U876_02015	COG0772	Belongs to the SEDS family
U876_02020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U876_02025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U876_02030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U876_02035	COG0849	cell division
U876_02040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U876_02045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
U876_02055	COG0653	protein targeting
U876_02065	COG0494	nUDIX hydrolase
U876_02070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
U876_02075	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
U876_02090	COG1459	type II secretion system
U876_02095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_02120	COG2186	Transcriptional regulator
U876_02125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
U876_02130	COG0508	dehydrogenase complex catalyzes the overall conversion of
U876_02135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U876_02140	COG5001	Diguanylate cyclase
U876_02140	COG3447	MASE1 domain protein
U876_02140	COG5002	protein histidine kinase activity
U876_02150	COG0840	transmembrane signaling receptor activity
U876_02155	COG0840	transmembrane signaling receptor activity
U876_02160	COG1752	Esterase of the alpha-beta hydrolase superfamily
U876_02165	COG1049	propionate catabolic process, 2-methylcitrate cycle
U876_02180	COG1280	lysine exporter protein (LysE YggA)
U876_02190	COG0523	cobalamin synthesis protein
U876_02195	COG0477	Major facilitator Superfamily
U876_02210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U876_02215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U876_02260	COG0784	Response regulator, receiver
U876_02260	COG0835	chemotaxis
U876_02265	COG1028	Short-chain dehydrogenase reductase Sdr
U876_02270	COG1444	tRNA N-acetyltransferase activity
U876_02295	COG1803	Methylglyoxal synthase
U876_02310	COG0252	asparaginase activity
U876_02330	COG1263	PTS System
U876_02330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_02335	COG0366	Alpha amylase catalytic
U876_02340	COG0110	maltose O-acetyltransferase activity
U876_02345	COG1522	sequence-specific DNA binding
U876_02350	COG5006	permease, DMT superfamily
U876_02360	COG1012	belongs to the aldehyde dehydrogenase family
U876_02365	COG1177	transmembrane transport
U876_02370	COG1176	ABC-type spermidine putrescine transport system, permease component I
U876_02375	COG3842	ATPase activity
U876_02380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U876_02385	COG0583	DNA-binding transcription factor activity
U876_02390	COG1757	Na H antiporter
U876_02430	COG0297	glycogen (starch) synthase activity
U876_02435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_02440	COG2813	Specifically methylates the guanine in position
U876_02445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U876_02450	COG2203	Gaf domain
U876_02450	COG5001	Diguanylate cyclase
U876_02450	COG4251	negative regulation of phosphorylation
U876_02450	COG3706	GGDEF domain
U876_02460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_02470	COG2995	paraquat-inducible protein a
U876_02475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U876_02475	COG3008	intermembrane lipid transfer
U876_02480	COG3009	Protein conserved in bacteria
U876_02485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
U876_02485	COG2885	chlorophyll binding
U876_02495	COG3240	lipase activity
U876_02500	COG3111	PFAM Bacterial OB fold (BOF) protein
U876_02510	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
U876_02515	COG1194	a g-specific adenine glycosylase
U876_02525	COG3409	Peptidoglycan-binding domain 1 protein
U876_02525	COG3267	Type II secretory pathway component ExeA
U876_02535	COG0617	tRNA 3'-terminal CCA addition
U876_02550	COG1346	cytolysis
U876_02555	COG1380	Effector of murein hydrolase LrgA
U876_02560	COG0583	DNA-binding transcription factor activity
U876_02585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U876_02590	COG0306	phosphate transporter
U876_02595	COG1392	Phosphate transport regulator
U876_02610	COG1560	Kdo2-lipid A biosynthetic process
U876_02615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U876_02615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U876_02620	COG1538	Outer membrane efflux protein
U876_02625	COG0494	nUDIX hydrolase
U876_02630	COG3151	Protein conserved in bacteria
U876_02640	COG3150	esterase
U876_02645	COG1051	belongs to the nudix hydrolase family
U876_02660	COG1566	PFAM secretion protein HlyD family protein
U876_02665	COG1289	transmembrane transporter activity
U876_02670	COG0187	DNA topoisomerase II activity
U876_02715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U876_02740	COG0204	Acyl-transferase
U876_02745	COG1842	Phage shock protein A
U876_02760	COG2827	Endonuclease containing a URI domain
U876_02770	COG2962	Rard protein
U876_02775	COG1573	uracil-dna glycosylase
U876_02780	COG0697	spore germination
U876_02790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U876_02795	COG1121	(ABC) transporter
U876_02800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
U876_02820	COG0739	heme binding
U876_02830	COG3068	Protein conserved in bacteria
U876_02850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U876_02870	COG1546	Belongs to the CinA family
U876_02875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
U876_02885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U876_02890	COG0527	aspartate kinase activity
U876_02895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U876_02930	COG1686	Belongs to the peptidase S11 family
U876_02935	COG0586	Pfam SNARE associated Golgi protein
U876_02940	COG1253	flavin adenine dinucleotide binding
U876_02945	COG0525	valine-tRNA ligase activity
U876_02950	COG2927	DNA polymerase III (CHI subunit)
U876_02955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_02960	COG0795	lipopolysaccharide-transporting ATPase activity
U876_02970	COG0795	lipopolysaccharide-transporting ATPase activity
U876_02985	COG0582	viral genome integration into host DNA
U876_03000	COG3561	AntA/AntB antirepressor
U876_03035	COG0004	ammonium transporteR
U876_03040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_03050	COG0084	hydrolase, TatD family'
U876_03055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_03065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U876_03070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
U876_03075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U876_03080	COG0813	purine-nucleoside phosphorylase activity
U876_03085	COG3447	MASE1 domain protein
U876_03085	COG5002	protein histidine kinase activity
U876_03085	COG5001	Diguanylate cyclase
U876_03095	COG0560	Phosphoserine phosphatase
U876_03120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
U876_03125	COG0776	regulation of translation
U876_03140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U876_03145	COG0735	belongs to the Fur family
U876_03170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
U876_03175	COG0513	Belongs to the DEAD box helicase family
U876_03180	COG3022	response to hydroperoxide
U876_03195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U876_03200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U876_03205	COG0762	integral membrane protein
U876_03210	COG1872	DUF167
U876_03225	COG4166	transmembrane transport
U876_03235	COG0110	maltose O-acetyltransferase activity
U876_03245	COG1024	Enoyl-CoA hydratase
U876_03260	COG4221	oxidoreductase activity
U876_03265	COG0442	prolyl-tRNA aminoacylation
U876_03270	COG0840	transmembrane signaling receptor activity
U876_03275	COG0632	four-way junction helicase activity
U876_03280	COG2255	four-way junction helicase activity
U876_03285	COG1271	oxidase subunit
U876_03290	COG1294	oxidase, subunit
U876_03295	COG4890	Cyd operon protein YbgT
U876_03300	COG3790	cyd operon protein YbgE
U876_03305	COG0824	Thioesterase
U876_03310	COG0811	peptide transport
U876_03325	COG0823	Involved in the tonB-independent uptake of proteins
U876_03330	COG2885	chlorophyll binding
U876_03335	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
U876_03350	COG0840	transmembrane signaling receptor activity
U876_03355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U876_03360	COG0676	glucose-6-phosphate 1-epimerase activity
U876_03365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U876_03370	COG1640	4-alpha-glucanotransferase
U876_03375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
U876_03395	COG1051	belongs to the nudix hydrolase family
U876_03400	COG2130	NADP-dependent
U876_03405	COG1764	response to oxidative stress
U876_03410	COG1846	Transcriptional regulator
U876_03425	COG1522	sequence-specific DNA binding
U876_03440	COG0561	phosphatase activity
U876_03455	COG0733	neurotransmitter:sodium symporter activity
U876_03465	COG0733	neurotransmitter:sodium symporter activity
U876_03490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_03505	COG1794	racemase activity, acting on amino acids and derivatives
U876_03520	COG2731	YhcH YjgK YiaL family protein
U876_03530	COG0668	transmembrane transport
U876_03540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_03585	COG0583	DNA-binding transcription factor activity
U876_03590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
U876_03600	COG0488	(ABC) transporter
U876_03605	COG0517	IMP dehydrogenase activity
U876_03605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U876_03610	COG1585	Membrane protein implicated in regulation of membrane protease activity
U876_03615	COG0330	HflC and HflK could
U876_03620	COG1648	precorrin-2 dehydrogenase activity
U876_03620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_03625	COG0175	sulfate reduction
U876_03630	COG2895	sulfate adenylyltransferase (ATP) activity
U876_03635	COG0471	metal ion transport
U876_03635	COG3273	potassium ion transport
U876_03640	COG0529	Catalyzes the synthesis of activated sulfate
U876_03660	COG0840	transmembrane signaling receptor activity
U876_03695	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
U876_03710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U876_03715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U876_03720	COG0163	prenyltransferase activity
U876_03735	COG1131	(ABC) transporter
U876_03740	COG0842	Transport permease protein
U876_03745	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
U876_03750	COG1924	4 iron, 4 sulfur cluster binding
U876_03770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
U876_03775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
U876_03790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_03795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U876_03800	COG1489	DNA binding
U876_03810	COG1643	Atp-dependent helicase
U876_03815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U876_03820	COG0346	lactoylglutathione lyase activity
U876_03830	COG2076	Multidrug Resistance protein
U876_03840	COG3437	response regulator, receiver
U876_03840	COG0784	Response regulator, receiver
U876_03850	COG0671	phosphoesterase, PA-phosphatase related
U876_03865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U876_03870	COG0038	chloride channel
U876_03880	COG0316	Belongs to the HesB IscA family
U876_03905	COG1280	lysine exporter protein (LysE YggA)
U876_03910	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
U876_03925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_03955	COG0745	RESPONSE REGULATOR receiver
U876_03960	COG3104	oligopeptide transport
U876_03965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U876_03970	COG1555	photosystem II stabilization
U876_03980	COG2350	Protein conserved in bacteria
U876_03985	COG2917	probably involved in intracellular septation
U876_03990	COG0076	glutamate decarboxylase activity
U876_03995	COG1272	protein, Hemolysin III
U876_04000	COG0569	domain protein
U876_04000	COG2985	domain, Protein
U876_04015	COG0835	chemotaxis
U876_04015	COG0784	Response regulator, receiver
U876_04020	COG2755	lipolytic protein G-D-S-L family
U876_04025	COG4181	ATPase activity
U876_04030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
U876_04035	COG1090	epimerase
U876_04040	COG2200	EAL domain
U876_04045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_04050	COG4935	Belongs to the peptidase S8 family
U876_04050	COG2234	aminopeptidase activity
U876_04055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U876_04060	COG3171	Protein conserved in bacteria
U876_04065	COG2066	Belongs to the glutaminase family
U876_04070	COG2897	thiosulfate sulfurtransferase activity
U876_04075	COG1404	Belongs to the peptidase S8 family
U876_04085	COG1132	(ABC) transporter
U876_04110	COG4412	M6 family metalloprotease domain protein
U876_04110	COG3291	Pkd domain containing protein
U876_04115	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
U876_04120	COG5001	Diguanylate cyclase
U876_04120	COG3300	MHYT domain
U876_04140	COG4628	conserved protein (DUF2132)
U876_04145	COG0688	phosphatidylethanolamine metabolic process
U876_04150	COG1162	GTPase activity
U876_04155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
U876_04185	COG1278	Cold shock
U876_04195	COG0840	transmembrane signaling receptor activity
U876_04200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_04255	COG0848	biopolymer transport protein
U876_04260	COG0811	peptide transport
U876_04265	COG0811	peptide transport
U876_04280	COG4174	ABC transporter (Permease)
U876_04285	COG4239	(ABC) transporter, permease
U876_04295	COG0444	Belongs to the ABC transporter superfamily
U876_04300	COG4608	Belongs to the ABC transporter superfamily
U876_04310	COG2195	Cleaves the N-terminal amino acid of tripeptides
U876_04315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
U876_04335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U876_04360	COG0243	molybdopterin cofactor binding
U876_04375	COG1116	anion transmembrane transporter activity
U876_04375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U876_04380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U876_04385	COG1116	anion transmembrane transporter activity
U876_04390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_04390	COG2146	nitrite reductase [NAD(P)H] activity
U876_04395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_04395	COG2146	nitrite reductase [NAD(P)H] activity
U876_04400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_04405	COG2313	pseudouridylate synthase activity
U876_04415	COG1858	cytochrome C peroxidase
U876_04450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_04455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_04480	COG2986	histidine ammonia-lyase
U876_04505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U876_04515	COG1028	Short-chain dehydrogenase reductase Sdr
U876_04530	COG0521	Mo-molybdopterin cofactor biosynthetic process
U876_04540	COG2966	Psort location CytoplasmicMembrane, score
U876_04545	COG3610	response to peptide
U876_04555	COG4175	Glycine betaine
U876_04560	COG4176	ABC-type proline glycine betaine transport system permease component
U876_04565	COG2113	Glycine betaine
U876_04570	COG0175	sulfate reduction
U876_04575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_04580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U876_04585	COG0384	phenazine biosynthesis protein PhzF
U876_04590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U876_04595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U876_04605	COG0786	glutamate:sodium symporter activity
U876_04610	COG0252	asparaginase activity
U876_04615	COG3139	Protein of unknown function (DUF1315)
U876_04635	COG0616	signal peptide processing
U876_04640	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_04640	COG1902	pentaerythritol trinitrate reductase activity
U876_04645	COG0778	Nitroreductase
U876_04660	COG2264	protein methyltransferase activity
U876_04665	COG0604	alcohol dehydrogenase
U876_04670	COG0583	DNA-binding transcription factor activity
U876_04675	COG1263	PTS System
U876_04675	COG2190	(PTS) system
U876_04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_04680	COG4145	pantothenate transmembrane transporter activity
U876_04690	COG0439	Biotin carboxylase
U876_04695	COG0511	ligase activity, forming carbon-carbon bonds
U876_04700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U876_04710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U876_04720	COG3300	MHYT domain
U876_04720	COG5001	Diguanylate cyclase
U876_04740	COG3381	protein complex oligomerization
U876_04755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U876_04770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U876_04775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U876_04775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U876_04795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U876_04800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
U876_04810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U876_04835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U876_04840	COG0142	geranyltranstransferase activity
U876_04845	COG1722	exodeoxyribonuclease VII activity
U876_04850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_04855	COG1360	Flagellar Motor Protein
U876_04860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U876_04870	COG1534	Rna-binding protein
U876_04875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
U876_04880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U876_04885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U876_04890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U876_04895	COG0149	triose-phosphate isomerase activity
U876_04900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U876_04915	COG0779	Required for maturation of 30S ribosomal subunits
U876_04920	COG0195	Participates in both transcription termination and antitermination
U876_04925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
U876_04930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
U876_04935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
U876_04940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
U876_04945	COG1185	polyribonucleotide nucleotidyltransferase activity
U876_04960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
U876_04970	COG0114	fumarate hydratase activity
U876_04980	COG1966	Carbon starvation protein
U876_04985	COG3279	Response regulator of the LytR AlgR family
U876_05060	COG0312	modulator of DNA gyrase
U876_05065	COG0312	modulator of DNA gyrase
U876_05070	COG0716	FMN binding
U876_05075	COG4974	Belongs to the 'phage' integrase family
U876_05080	COG1970	mechanosensitive ion channel activity
U876_05085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_05095	COG0789	Transcriptional regulator
U876_05110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_05115	COG3545	Serine hydrolase
U876_05125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
U876_05135	COG0321	lipoyl(octanoyl) transferase activity
U876_05140	COG2921	Belongs to the UPF0250 family
U876_05145	COG1686	Belongs to the peptidase S11 family
U876_05150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U876_05155	COG2951	lytic endotransglycosylase activity
U876_05165	COG0772	Belongs to the SEDS family
U876_05170	COG0768	penicillin binding
U876_05175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
U876_05180	COG0799	negative regulation of ribosome biogenesis
U876_05185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U876_05200	COG0495	leucyl-tRNA aminoacylation
U876_05205	COG2888	peptidyl-tyrosine sulfation
U876_05210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
U876_05215	COG4535	Mg2 and Co2 transporter CorC
U876_05220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
U876_05225	COG1702	phosphate starvation-inducible protein PhoH
U876_05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U876_05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_05240	COG1335	isochorismatase
U876_05250	COG3706	GGDEF domain
U876_05265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_05275	COG3706	GGDEF domain
U876_05285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U876_05295	COG3647	Membrane
U876_05300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U876_05310	COG0516	GMP reductase activity
U876_05320	COG0642	Histidine kinase
U876_05325	COG0745	RESPONSE REGULATOR receiver
U876_05360	COG3214	Protein conserved in bacteria
U876_05385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
U876_05390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U876_05395	COG1053	succinate dehydrogenase
U876_05405	COG0584	glycerophosphoryl diester phosphodiesterase
U876_05410	COG1511	domain protein
U876_05410	COG3264	Mechanosensitive ion channel
U876_05420	COG0739	heme binding
U876_05435	COG0583	DNA-binding transcription factor activity
U876_05455	COG0583	DNA-binding transcription factor activity
U876_05460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
U876_05490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
U876_05495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
U876_05505	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U876_05510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U876_05520	COG0180	Tryptophanyl-tRNA synthetase
U876_05535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U876_05545	COG1012	belongs to the aldehyde dehydrogenase family
U876_05555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_05565	COG0674	pyruvate-flavodoxin oxidoreductase activity
U876_05565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U876_05565	COG1013	pyruvate-flavodoxin oxidoreductase activity
U876_05565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_05595	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
U876_05605	COG0471	metal ion transport
U876_05605	COG0490	domain, Protein
U876_05650	COG0012	GTP binding
U876_05655	COG0193	aminoacyl-tRNA hydrolase activity
U876_05660	COG0737	Belongs to the 5'-nucleotidase family
U876_05665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U876_05675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
U876_05680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
U876_05685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U876_05690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
U876_05695	COG2890	protein-(glutamine-N5) methyltransferase activity
U876_05705	COG2912	Transglutaminase-like superfamily
U876_05710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
U876_05715	COG1301	dicarboxylic acid transport
U876_05725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
U876_05740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U876_05745	COG1115	amino acid carrier protein
U876_05760	COG0714	Associated with various cellular activities
U876_05770	COG3104	oligopeptide transport
U876_05775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U876_05780	COG1678	Uncharacterized ACR, COG1678
U876_05790	COG0189	ligase activity
U876_05795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U876_05805	COG3091	SprT-like family
U876_05815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U876_05855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
U876_05870	COG0739	heme binding
U876_05875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U876_05880	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
U876_05880	COG3408	Glycogen debranching enzyme
U876_05890	COG1881	PFAM PEBP family protein
U876_05900	COG0583	DNA-binding transcription factor activity
U876_05910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U876_05920	COG0583	DNA-binding transcription factor activity
U876_05925	COG1028	Short-chain dehydrogenase reductase Sdr
U876_05930	COG0616	signal peptide processing
U876_05935	COG3724	N-succinylarginine dihydrolase activity
U876_05940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U876_05955	COG0840	transmembrane signaling receptor activity
U876_05970	COG2971	BadF BadG BcrA BcrD
U876_05980	COG4608	Belongs to the ABC transporter superfamily
U876_05985	COG0444	Belongs to the ABC transporter superfamily
U876_05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_05995	COG0601	transmembrane transport
U876_06000	COG4166	transmembrane transport
U876_06035	COG3220	belongs to the UPF0276 family
U876_06065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_06070	COG1289	transmembrane transporter activity
U876_06075	COG0303	'Molybdopterin
U876_06080	COG0746	molybdenum cofactor guanylyltransferase activity
U876_06090	COG4662	Binding-protein-dependent transport system inner membrane component
U876_06100	COG2204	response regulator
U876_06105	COG3852	Histidine kinase
U876_06110	COG1910	domain protein
U876_06115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U876_06155	COG3383	formate dehydrogenase (NAD+) activity
U876_06155	COG3383	formate dehydrogenase (NAD+) activity
U876_06160	COG0437	4 iron, 4 sulfur cluster binding
U876_06175	COG0281	malic enzyme
U876_06195	COG2706	6-phosphogluconolactonase activity
U876_06205	COG1196	nuclear chromosome segregation
U876_06205	COG3264	Mechanosensitive ion channel
U876_06210	COG0469	pyruvate kinase activity
U876_06225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U876_06225	COG4651	solute:proton antiporter activity
U876_06240	COG2974	May be involved in recombination
U876_06250	COG0420	3'-5' exonuclease activity
U876_06255	COG0419	ATPase involved in DNA repair
U876_06270	COG3038	cytochrome b561
U876_06285	COG2190	(PTS) system
U876_06295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_06300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U876_06305	COG0542	response to heat
U876_06320	COG1720	tRNA m6t6A37 methyltransferase activity
U876_06340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
U876_06345	COG4988	ABC transporter
U876_06360	COG0745	RESPONSE REGULATOR receiver
U876_06375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
U876_06395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
U876_06405	COG0083	homoserine kinase activity
U876_06410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U876_06415	COG4319	ketosteroid isomerase
U876_06430	COG0488	(ABC) transporter
U876_06450	COG0813	purine-nucleoside phosphorylase activity
U876_06465	COG2205	protein histidine kinase activity
U876_06465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_06470	COG3384	dioxygenase
U876_06485	COG1283	sodium-dependent phosphate transmembrane transporter activity
U876_06495	COG0531	amino acid
U876_06505	COG0531	amino acid
U876_06525	COG1396	sequence-specific DNA binding
U876_06525	COG1917	Cupin 2, conserved barrel domain protein
U876_06530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_06550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_06555	COG2375	cellular response to nickel ion
U876_06560	COG1538	Outer membrane efflux protein
U876_06565	COG1136	(ABC) transporter
U876_06565	COG0577	efflux transmembrane transporter activity
U876_06570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_06580	COG1227	inorganic diphosphatase activity
U876_06590	COG0497	DNA recombination
U876_06595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U876_06600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U876_06605	COG0443	Heat shock 70 kDa protein
U876_06610	COG0484	heat shock protein binding
U876_06640	COG1285	pathogenesis
U876_06655	COG0640	Transcriptional regulator
U876_06685	COG0095	Lipoate-protein ligase
U876_06705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_06710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_06730	COG0708	Exodeoxyribonuclease III
U876_06790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U876_06795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U876_06800	COG1845	cytochrome c oxidase, subunit III
U876_06805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U876_06810	COG0109	protoheme IX farnesyltransferase activity
U876_06815	COG2814	Major facilitator Superfamily
U876_06825	COG2175	clavaminate synthase activity
U876_06830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U876_06835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
U876_06840	COG4521	taurine ABC transporter
U876_06850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_06875	COG1988	membrane-bound metal-dependent
U876_06885	COG0159	tryptophan synthase activity
U876_06890	COG0133	tryptophan synthase activity
U876_06895	COG0135	phosphoribosylanthranilate isomerase activity
U876_06895	COG0134	indole-3-glycerol-phosphate synthase activity
U876_06900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U876_06905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U876_06905	COG0512	Glutamine amidotransferase of anthranilate synthase
U876_06910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U876_06920	COG0009	L-threonylcarbamoyladenylate synthase
U876_06930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
U876_06940	COG1946	Acyl-CoA thioesterase
U876_06960	COG1309	transcriptional regulator
U876_06965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_06970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_06975	COG1538	Outer membrane efflux protein
U876_06985	COG1091	dTDP-4-dehydrorhamnose reductase activity
U876_07025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U876_07045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
U876_07055	COG1086	Polysaccharide biosynthesis protein
U876_07085	COG3206	protein involved in exopolysaccharide biosynthesis
U876_07085	COG0489	protein tyrosine kinase activity
U876_07095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_07105	COG3132	Protein of unknown function, DUF480
U876_07145	COG1278	Cold shock
U876_07175	COG0697	spore germination
U876_07180	COG1349	DNA-binding transcription factor activity
U876_07190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_07195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U876_07210	COG1187	pseudouridine synthase activity
U876_07225	COG0622	Phosphoesterase
U876_07240	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
U876_07245	COG0784	Response regulator, receiver
U876_07245	COG0835	chemotaxis
U876_07250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U876_07255	COG1815	bacterial-type flagellum-dependent cell motility
U876_07260	COG1558	bacterial-type flagellum-dependent cell motility
U876_07275	COG4787	bacterial-type flagellum-dependent cell motility
U876_07280	COG4786	Flagellar basal body rod
U876_07285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
U876_07290	COG1706	bacterial-type flagellum-dependent cell motility
U876_07295	COG1705	Flagellar rod assembly protein muramidase FlgJ
U876_07295	COG3951	Flagellar rod assembly protein muramidase FlgJ
U876_07300	COG1256	bacterial-type flagellum assembly
U876_07310	COG2239	Acts as a magnesium transporter
U876_07315	COG0248	Ppx GppA phosphatase
U876_07320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
U876_07325	COG2716	regulation of RNA biosynthetic process
U876_07335	COG2204	response regulator
U876_07340	COG3852	Histidine kinase
U876_07345	COG2204	response regulator
U876_07350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U876_07355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
U876_07360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
U876_07365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
U876_07385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
U876_07400	COG0590	tRNA wobble adenosine to inosine editing
U876_07405	COG0573	inorganic phosphate transmembrane transporter activity
U876_07410	COG0581	inorganic phosphate transmembrane transporter activity
U876_07425	COG0704	Plays a role in the regulation of phosphate uptake
U876_07430	COG1253	flavin adenine dinucleotide binding
U876_07445	COG0531	amino acid
U876_07460	COG1126	abc transporter atp-binding protein
U876_07465	COG0765	amino acid transport
U876_07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_07475	COG3706	GGDEF domain
U876_07480	COG2271	Major facilitator Superfamily
U876_07495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U876_07525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U876_07530	COG0477	Major facilitator Superfamily
U876_07535	COG0123	including yeast histone deacetylase and acetoin utilization protein
U876_07545	COG1199	ATP-dependent helicase activity
U876_07550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
U876_07560	COG1448	Aminotransferase
U876_07565	COG0433	COG0433 Predicted ATPase
U876_07670	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_07715	COG1663	tetraacyldisaccharide 4'-kinase activity
U876_07720	COG2835	tetraacyldisaccharide 4'-kinase activity
U876_07725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
U876_07730	COG2197	response regulator
U876_07735	COG0322	excinuclease ABC activity
U876_07760	COG0582	viral genome integration into host DNA
U876_07785	COG4372	Transposase
U876_07805	COG3962	Belongs to the TPP enzyme family
U876_07820	COG0673	inositol 2-dehydrogenase activity
U876_07825	COG1879	ABC-type sugar transport system periplasmic component
U876_07835	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_07840	COG0673	inositol 2-dehydrogenase activity
U876_07845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_07855	COG3718	enzyme involved in inositol metabolism
U876_07865	COG2963	transposase activity
U876_07870	COG2801	Transposase and inactivated derivatives
U876_07935	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
U876_07940	COG0437	4 iron, 4 sulfur cluster binding
U876_07945	COG3301	Polysulphide reductase, NrfD
U876_07950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_07960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U876_07965	COG0215	cysteine-tRNA ligase activity
U876_07985	COG2203	Gaf domain
U876_07985	COG2199	diguanylate cyclase activity
U876_08015	COG2119	membrane
U876_08020	COG0023	Translation Initiation Factor
U876_08045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_08060	COG2205	protein histidine kinase activity
U876_08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_08070	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
U876_08080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_08085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U876_08090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U876_08095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U876_08100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U876_08105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U876_08115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
U876_08120	COG0505	Belongs to the CarA family
U876_08125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U876_08130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U876_08160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U876_08165	COG0513	Belongs to the DEAD box helicase family
U876_08175	COG4104	PAAR repeat-containing protein
U876_08190	COG0789	Transcriptional regulator
U876_08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_08210	COG0765	amino acid transport
U876_08220	COG0493	'glutamate synthase
U876_08225	COG0070	glutamate synthase
U876_08225	COG0069	glutamate synthase activity
U876_08225	COG0067	glutamate synthase
U876_08230	COG1242	4 iron, 4 sulfur cluster binding
U876_08290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
U876_08295	COG0574	Belongs to the PEP-utilizing enzyme family
U876_08295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U876_08350	COG1464	Belongs to the NlpA lipoprotein family
U876_08355	COG0671	phosphoesterase, PA-phosphatase related
U876_08360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U876_08365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U876_08375	COG0101	tRNA pseudouridine synthase activity
U876_08380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U876_08385	COG0285	dihydrofolate synthase activity
U876_08390	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
U876_08395	COG2920	part of a sulfur-relay system
U876_08400	COG1289	transmembrane transporter activity
U876_08405	COG0670	Belongs to the BI1 family
U876_08425	COG2194	sulfuric ester hydrolase activity
U876_08435	COG0392	lysyltransferase activity
U876_08435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
U876_08445	COG0840	transmembrane signaling receptor activity
U876_08450	COG5001	Diguanylate cyclase
U876_08455	COG0564	pseudouridine synthase activity
U876_08470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
U876_08480	COG0625	glutathione transferase activity
U876_08485	COG0625	glutathione transferase activity
U876_08495	COG0367	asparagine synthase
U876_08505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U876_08505	COG4651	solute:proton antiporter activity
U876_08510	COG0647	UMP catabolic process
U876_08515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
U876_08520	COG1902	pentaerythritol trinitrate reductase activity
U876_08525	COG1253	flavin adenine dinucleotide binding
U876_08535	COG0277	FAD linked oxidase domain protein
U876_08535	COG0247	lactate metabolic process
U876_08545	COG2050	protein possibly involved in aromatic compounds catabolism
U876_08555	COG2056	Na+-H+ antiporter family
U876_08560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_08575	COG0346	lactoylglutathione lyase activity
U876_08580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U876_08590	COG4659	FMN binding
U876_08595	COG4658	electron transport chain
U876_08605	COG2878	Part of a membrane complex involved in electron transport
U876_08610	COG4657	Part of a membrane complex involved in electron transport
U876_08615	COG0697	spore germination
U876_08630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U876_08635	COG1288	antiporter activity
U876_08640	COG0436	Aminotransferase
U876_08650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U876_08655	COG2027	D-alanyl-D-alanine carboxypeptidase
U876_08660	COG1061	Type III restriction enzyme res subunit
U876_08665	COG1566	PFAM secretion protein HlyD family protein
U876_08675	COG1966	Carbon starvation protein
U876_08680	COG3279	Response regulator of the LytR AlgR family
U876_08685	COG3275	phosphorelay sensor kinase activity
U876_08690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_08690	COG2199	diguanylate cyclase activity
U876_08695	COG1012	belongs to the aldehyde dehydrogenase family
U876_08695	COG1454	alcohol dehydrogenase
U876_08705	COG2095	MarC family integral membrane protein
U876_08715	COG0601	transmembrane transport
U876_08720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_08725	COG0444	Belongs to the ABC transporter superfamily
U876_08740	COG0861	Integral membrane protein TerC family
U876_08745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_08755	COG1301	dicarboxylic acid transport
U876_08770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U876_08775	COG0582	viral genome integration into host DNA
U876_08820	COG2974	May be involved in recombination
U876_08855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_08995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_09185	COG0537	adenosine 5'-monophosphoramidase activity
U876_09220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_09225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_09235	COG2354	Protein conserved in bacteria
U876_09250	COG2233	PERMEase
U876_09260	COG1252	NADH dehydrogenase
U876_09280	COG0393	Putative heavy-metal-binding
U876_09290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_09290	COG1648	precorrin-2 dehydrogenase activity
U876_09295	COG2221	Nitrite and sulphite reductase 4Fe-4S
U876_09310	COG4667	esterase of the alpha-beta hydrolase superfamily
U876_09315	COG1619	proteins homologs of microcin C7 resistance protein MccF
U876_09320	COG1368	sulfuric ester hydrolase activity
U876_09330	COG0527	aspartate kinase activity
U876_09335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U876_09335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U876_09340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U876_09365	COG0596	Alpha beta hydrolase
U876_09370	COG0346	lactoylglutathione lyase activity
U876_09380	COG0583	DNA-binding transcription factor activity
U876_09385	COG1620	l-lactate permease
U876_09395	COG1139	Iron-sulfur cluster binding protein
U876_09420	COG1136	(ABC) transporter
U876_09430	COG2814	Major facilitator Superfamily
U876_09450	COG0672	)-iron permease
U876_09480	COG0659	secondary active sulfate transmembrane transporter activity
U876_09545	COG2963	transposase activity
U876_09565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_09570	COG0840	transmembrane signaling receptor activity
U876_09580	COG2201	protein-glutamate methylesterase activity
U876_09590	COG0835	chemotaxis
U876_09595	COG3290	protein histidine kinase activity
U876_09595	COG0840	transmembrane signaling receptor activity
U876_09600	COG2198	Histidine kinase
U876_09600	COG0643	Histidine kinase
U876_09610	COG0745	RESPONSE REGULATOR receiver
U876_09615	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U876_09620	COG0437	4 iron, 4 sulfur cluster binding
U876_09625	COG5557	Pfam Polysulphide reductase, NrfD
U876_09630	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U876_09635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U876_09640	COG1773	rubredoxin
U876_09645	COG0747	negative chemotaxis
U876_09650	COG0601	transmembrane transport
U876_09655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_09660	COG0444	Belongs to the ABC transporter superfamily
U876_09665	COG3842	ATPase activity
U876_09670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
U876_09675	COG0375	protein maturation
U876_09680	COG0309	Hydrogenase expression formation protein (HypE)
U876_09690	COG0298	carbon dioxide binding
U876_09695	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
U876_09705	COG1921	L-seryl-tRNASec selenium transferase activity
U876_09715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U876_09725	COG3260	NADH ubiquinone oxidoreductase 20
U876_09730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_09735	COG3261	NADH dehydrogenase
U876_09735	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
U876_09740	COG0650	Formate hydrogenlyase subunit 4
U876_09745	COG0651	ATP synthesis coupled electron transport
U876_09750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_09755	COG3158	transport of potassium into the cell
U876_09765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_09770	COG3383	formate dehydrogenase (NAD+) activity
U876_09775	COG3383	formate dehydrogenase (NAD+) activity
U876_09795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
U876_09800	COG0326	Molecular chaperone. Has ATPase activity
U876_09805	COG0563	adenylate kinase activity
U876_09810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
U876_09820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_09835	COG5001	Diguanylate cyclase
U876_09835	COG3300	MHYT domain
U876_09840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_09860	COG1021	2,3-dihydroxybenzoate-AMP ligase
U876_09865	COG1535	isochorismatase
U876_09865	COG3433	isochorismatase activity
U876_09870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U876_09875	COG1028	Short-chain dehydrogenase reductase Sdr
U876_09885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U876_09890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U876_09895	COG2977	Belongs to the P-Pant transferase superfamily
U876_09900	COG1120	ATPase activity
U876_09905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_09910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_09915	COG4771	TonB-dependent receptor
U876_09935	COG0598	Magnesium transport protein CorA
U876_09960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U876_09965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
U876_09970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_09985	COG1570	exodeoxyribonuclease VII activity
U876_09990	COG0697	spore germination
U876_10010	COG3158	transport of potassium into the cell
U876_10015	COG0517	IMP dehydrogenase activity
U876_10015	COG0516	GMP reductase activity
U876_10020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U876_10020	COG0519	Catalyzes the synthesis of GMP from XMP
U876_10025	COG0582	viral genome integration into host DNA
U876_10090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U876_10090	COG2169	Transcriptional regulator
U876_10115	COG2062	phosphohistidine phosphatase, SixA
U876_10125	COG0697	spore germination
U876_10130	COG4166	transmembrane transport
U876_10135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
U876_10140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U876_10150	COG4591	ABC-type transport system involved in lipoprotein release permease component
U876_10155	COG1136	(ABC) transporter
U876_10160	COG4591	ABC-type transport system involved in lipoprotein release permease component
U876_10165	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
U876_10175	COG0544	peptidyl-prolyl cis-trans isomerase activity
U876_10180	COG0740	serine-type endopeptidase activity
U876_10185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U876_10190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U876_10195	COG0776	regulation of translation
U876_10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U876_10205	COG0488	(ABC) transporter
U876_10210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_10215	COG3162	membrane
U876_10230	COG1024	Enoyl-CoA hydratase
U876_10275	COG1115	amino acid carrier protein
U876_10290	COG1584	GPR1 FUN34 yaaH family protein
U876_10330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U876_10335	COG1960	acyl-CoA dehydrogenase activity
U876_10345	COG1960	acyl-CoA dehydrogenase activity
U876_10350	COG1024	Enoyl-CoA hydratase
U876_10355	COG1024	Enoyl-CoA hydratase
U876_10365	COG1028	Short-chain dehydrogenase reductase Sdr
U876_10375	COG0730	response to heat
U876_10390	COG2801	Transposase and inactivated derivatives
U876_10400	COG5002	protein histidine kinase activity
U876_10400	COG5001	Diguanylate cyclase
U876_10425	COG2003	Belongs to the UPF0758 family
U876_10445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U876_10460	COG1073	alpha beta
U876_10465	COG1506	peptidase
U876_10465	COG0823	Involved in the tonB-independent uptake of proteins
U876_10470	COG0702	epimerase
U876_10475	COG0583	DNA-binding transcription factor activity
U876_10480	COG0667	Aldo Keto reductase
U876_10495	COG3706	GGDEF domain
U876_10500	COG0583	DNA-binding transcription factor activity
U876_10505	COG2723	6-phospho-beta-galactosidase activity
U876_10510	COG5001	Diguanylate cyclase
U876_10510	COG3300	MHYT domain
U876_10525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_10530	COG1028	Short-chain dehydrogenase reductase Sdr
U876_10535	COG0583	DNA-binding transcription factor activity
U876_10540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
U876_10545	COG0673	inositol 2-dehydrogenase activity
U876_10550	COG0583	DNA-binding transcription factor activity
U876_10560	COG1560	Kdo2-lipid A biosynthetic process
U876_10565	COG1560	Kdo2-lipid A biosynthetic process
U876_10590	COG0417	DNA replication proofreading
U876_10620	COG0534	Mate efflux family protein
U876_10630	COG0307	riboflavin synthase, alpha
U876_10640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_10645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
U876_10650	COG0697	spore germination
U876_10655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U876_10695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U876_10705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
U876_10710	COG2894	cell division
U876_10715	COG0850	regulation of cytokinetic process
U876_10720	COG3100	YcgL domain-containing protein
U876_10725	COG2951	lytic endotransglycosylase activity
U876_10730	COG1760	l-serine dehydratase
U876_10735	COG1760	l-serine dehydratase
U876_10740	COG3123	guanosine phosphorylase activity
U876_10760	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
U876_10765	COG2067	long-chain fatty acid transport protein
U876_10780	COG1595	DNA-templated transcription, initiation
U876_10810	COG0714	Associated with various cellular activities
U876_10815	COG0183	Belongs to the thiolase family
U876_10820	COG1024	Enoyl-CoA hydratase
U876_10820	COG1250	3-hydroxyacyl-CoA dehydrogenase
U876_10830	COG4681	YaeQ
U876_10840	COG4383	Mu-like prophage protein gp29
U876_10855	COG4388	Caudovirus prohead serine protease
U876_10865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U876_10870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U876_10875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U876_10885	COG0549	Belongs to the carbamate kinase family
U876_10895	COG0697	spore germination
U876_10900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U876_10900	COG3608	succinylglutamate desuccinylase aspartoacylase
U876_10905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U876_10910	COG2068	MobA-Related Protein
U876_10920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_10920	COG0493	'glutamate synthase
U876_10925	COG0402	S-adenosylhomocysteine deaminase activity
U876_10930	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U876_10935	COG2080	2 iron, 2 sulfur cluster binding
U876_10935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U876_10940	COG2233	PERMEase
U876_10945	COG0402	S-adenosylhomocysteine deaminase activity
U876_10950	COG2252	PERMEase
U876_10955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U876_10960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U876_10965	COG2080	2 iron, 2 sulfur cluster binding
U876_10975	COG3134	Outer membrane lipoprotein
U876_10985	COG1288	antiporter activity
U876_10990	COG0318	PFAM AMP-dependent synthetase and ligase
U876_10995	COG0140	phosphoribosyl-ATP diphosphatase activity
U876_10995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U876_11000	COG0107	imidazoleglycerol-phosphate synthase activity
U876_11005	COG2205	protein histidine kinase activity
U876_11005	COG0784	Response regulator, receiver
U876_11005	COG2198	Histidine kinase
U876_11015	COG3437	response regulator, receiver
U876_11020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
U876_11025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U876_11030	COG0131	Imidazoleglycerol-phosphate dehydratase
U876_11030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U876_11035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U876_11040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U876_11045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
U876_11055	COG1199	ATP-dependent helicase activity
U876_11060	COG1214	PFAM Peptidase M22, glycoprotease
U876_11070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
U876_11070	COG0596	Alpha beta hydrolase
U876_11070	COG2226	methyltransferase
U876_11075	COG0318	PFAM AMP-dependent synthetase and ligase
U876_11080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
U876_11215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U876_11225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U876_11230	COG2832	Protein of unknown function (DUF454)
U876_11235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U876_11245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
U876_11250	COG0582	viral genome integration into host DNA
U876_11280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_11385	COG0753	catalase activity
U876_11410	COG3646	Phage regulatory protein
U876_11410	COG3645	SOS response
U876_11435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_11440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_11455	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_11625	COG1643	Atp-dependent helicase
U876_11645	COG3437	response regulator, receiver
U876_11650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U876_11655	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
U876_11660	COG0709	Synthesizes selenophosphate from selenide and ATP
U876_11685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U876_11690	COG0840	transmembrane signaling receptor activity
U876_11695	COG1254	Belongs to the acylphosphatase family
U876_11700	COG0625	glutathione transferase activity
U876_11705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_11705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_11710	COG0489	protein tyrosine kinase activity
U876_11715	COG0572	uridine kinase
U876_11720	COG0717	Belongs to the dCTP deaminase family
U876_11730	COG0306	phosphate transporter
U876_11735	COG1530	ribonuclease E activity
U876_11740	COG0564	pseudouridine synthase activity
U876_11750	COG0424	maF-like protein
U876_11755	COG2814	Major facilitator Superfamily
U876_11770	COG1399	metal-binding, possibly nucleic acid-binding protein
U876_11775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
U876_11780	COG0416	fatty acid biosynthetic process
U876_11785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U876_11795	COG1028	Short-chain dehydrogenase reductase Sdr
U876_11800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_11805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U876_11810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U876_11815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U876_11820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U876_11825	COG0470	DNA polymerase III
U876_11830	COG0084	hydrolase, TatD family'
U876_11845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
U876_11845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_11850	COG3008	intermembrane lipid transfer
U876_11855	COG2995	paraquat-inducible protein a
U876_11865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
U876_11870	COG0372	Belongs to the citrate synthase family
U876_11915	COG4221	oxidoreductase activity
U876_11925	COG3141	response to X-ray
U876_11935	COG1067	ATP-dependent peptidase activity
U876_11940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U876_11955	COG0488	(ABC) transporter
U876_11965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U876_11965	COG0116	Belongs to the methyltransferase superfamily
U876_11975	COG0167	dihydroorotate dehydrogenase activity
U876_11980	COG2902	Dehydrogenase
U876_11990	COG0308	aminopeptidase N
U876_12000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
U876_12005	COG1956	GAF domain-containing protein
U876_12015	COG3278	Belongs to the heme-copper respiratory oxidase family
U876_12030	COG2010	Cytochrome c
U876_12055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U876_12060	COG0589	response to stress
U876_12065	COG0037	tRNA processing
U876_12080	COG0625	glutathione transferase activity
U876_12085	COG1869	D-ribose catabolic process
U876_12090	COG1129	ABC transporter
U876_12095	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_12100	COG1879	ABC-type sugar transport system periplasmic component
U876_12105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_12110	COG1609	Transcriptional regulator
U876_12125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U876_12145	COG0776	regulation of translation
U876_12150	COG0072	phenylalanine-tRNA ligase activity
U876_12150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_12155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
U876_12160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U876_12165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
U876_12170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U876_12175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U876_12200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U876_12210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_12215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_12220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_12225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
U876_12230	COG3313	Fe-S protein
U876_12235	COG2942	2-epimerase
U876_12240	COG3716	PTS system mannose fructose sorbose family IID component
U876_12245	COG3715	PTS system
U876_12250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_12250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_12265	COG1609	Transcriptional regulator
U876_12270	COG2140	Oxalate decarboxylase
U876_12275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_12275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
U876_12275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_12280	COG1105	Belongs to the carbohydrate kinase PfkB family
U876_12285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_12285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_12290	COG1609	Transcriptional regulator
U876_12295	COG0814	amino acid
U876_12305	COG5654	RES domain protein
U876_12310	COG0513	Belongs to the DEAD box helicase family
U876_12320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U876_12325	COG2890	protein-(glutamine-N5) methyltransferase activity
U876_12330	COG2840	Smr protein MutS2
U876_12340	COG3706	GGDEF domain
U876_12345	COG0588	phosphoglycerate mutase activity
U876_12375	COG2824	Alkylphosphonate utilization operon protein PhnA
U876_12395	COG0384	phenazine biosynthesis protein PhzF
U876_12410	COG0242	peptide deformylase activity
U876_12430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
U876_12435	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
U876_12445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U876_12450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
U876_12460	COG0205	6-phosphofructokinase activity
U876_12465	COG1473	amidohydrolase
U876_12470	COG1011	Hydrolase
U876_12475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_12510	COG3593	DNA synthesis involved in DNA repair
U876_12525	COG0583	DNA-binding transcription factor activity
U876_12530	COG0730	response to heat
U876_12550	COG1181	Belongs to the D-alanine--D-alanine ligase family
U876_12560	COG0386	Belongs to the glutathione peroxidase family
U876_12565	COG0513	Belongs to the DEAD box helicase family
U876_12570	COG0456	acetyltransferase
U876_12580	COG1742	UPF0060 membrane protein
U876_12610	COG2329	Antibiotic biosynthesis monooxygenase
U876_12615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
U876_12645	COG3243	poly(R)-hydroxyalkanoic acid synthase
U876_12655	COG2501	S4 domain
U876_12670	COG1132	(ABC) transporter
U876_12680	COG1132	(ABC) transporter
U876_12690	COG3118	belongs to the thioredoxin family
U876_12695	COG0471	metal ion transport
U876_12700	COG0058	SHG alpha-glucan phosphorylase activity
U876_12735	COG0814	amino acid
U876_12740	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
U876_12745	COG0514	ATP-dependent DNA helicase (RecQ)
U876_12750	COG2766	serine protein kinase
U876_12760	COG2719	SpoVR family
U876_12765	COG2186	Transcriptional regulator
U876_12770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_12775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U876_12780	COG0586	Pfam SNARE associated Golgi protein
U876_12790	COG0556	nucleotide-excision repair
U876_12800	COG2985	domain, Protein
U876_12800	COG0569	domain protein
U876_12805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
U876_12825	COG4565	transcriptional regulatory protein
U876_12830	COG3290	protein histidine kinase activity
U876_12835	COG1940	carbohydrate kinase activity
U876_12835	COG1846	Transcriptional regulator
U876_12840	COG0840	transmembrane signaling receptor activity
U876_12845	COG3012	SEC-C Motif Domain Protein
U876_12850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U876_12855	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
U876_12860	COG0247	lactate metabolic process
U876_12880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
U876_12885	COG0437	4 iron, 4 sulfur cluster binding
U876_12890	COG3301	Polysulphide reductase, NrfD
U876_12895	COG1138	Cytochrome C-type biogenesis protein
U876_12910	COG1051	belongs to the nudix hydrolase family
U876_12920	COG3033	Beta-eliminating lyase
U876_12925	COG3046	protein related to deoxyribodipyrimidine photolyase
U876_12930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_12955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U876_12960	COG0583	DNA-binding transcription factor activity
U876_12970	COG4774	siderophore transport
U876_12975	COG4977	sequence-specific DNA binding
U876_12985	COG0583	DNA-binding transcription factor activity
U876_12990	COG2910	NAD(P)H-binding
U876_13000	COG0626	cystathionine gamma-synthase activity
U876_13005	COG0612	Peptidase, M16
U876_13010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U876_13015	COG2076	Multidrug Resistance protein
U876_13020	COG1944	ATP diphosphatase activity
U876_13025	COG2116	formate transmembrane transporter activity
U876_13030	COG1882	Formate acetyltransferase
U876_13035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_13045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U876_13055	COG1840	ABC-type Fe3 transport system, periplasmic component
U876_13060	COG3842	ATPase activity
U876_13070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_13075	COG2983	Belongs to the UPF0260 family
U876_13085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U876_13090	COG0045	succinate-CoA ligase (ADP-forming) activity
U876_13095	COG0508	dehydrogenase complex catalyzes the overall conversion of
U876_13100	COG0567	Dehydrogenase, E1 component
U876_13110	COG1053	succinate dehydrogenase
U876_13115	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
U876_13120	COG2009	succinate dehydrogenase
U876_13140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U876_13145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_13145	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
U876_13155	COG3069	C4-dicarboxylate transmembrane transporter activity
U876_13170	COG1451	nucleotide metabolic process
U876_13185	COG0254	rRNA binding
U876_13190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
U876_13200	COG0583	DNA-binding transcription factor activity
U876_13210	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_13220	COG1879	ABC-type sugar transport system periplasmic component
U876_13225	COG1069	ribulokinase activity
U876_13235	COG2160	L-arabinose isomerase activity
U876_13240	COG2925	Exonuclease
U876_13250	COG3345	alpha-galactosidase
U876_13255	COG1380	Effector of murein hydrolase LrgA
U876_13260	COG1346	cytolysis
U876_13265	COG0295	cytidine deaminase activity
U876_13270	COG1022	Amp-dependent synthetase and ligase
U876_13285	COG0861	Integral membrane protein TerC family
U876_13290	COG2885	chlorophyll binding
U876_13295	COG2199	diguanylate cyclase activity
U876_13310	COG2154	pterin-4-alpha-carbinolamine dehydratase
U876_13315	COG2154	pterin-4-alpha-carbinolamine dehydratase
U876_13325	COG3768	UPF0283 membrane protein
U876_13330	COG3106	COG3106 Predicted ATPase
U876_13345	COG1842	Phage shock protein A
U876_13350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U876_13360	COG4168	peptide transport system, permease
U876_13365	COG4171	peptide transport system, permease
U876_13380	COG4172	Belongs to the ABC transporter superfamily
U876_13390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
U876_13395	COG1286	toxin biosynthetic process
U876_13400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
U876_13405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U876_13410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U876_13415	COG1674	ftsk spoiiie
U876_13415	COG0531	amino acid
U876_13425	COG0492	ferredoxin-NADP+ reductase activity
U876_13430	COG3706	GGDEF domain
U876_13435	COG3134	Outer membrane lipoprotein
U876_13440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
U876_13445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
U876_13450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
U876_13455	COG0542	response to heat
U876_13460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
U876_13465	COG1278	Cold shock
U876_13470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
U876_13495	COG3179	chitinase
U876_13500	COG3501	Rhs element vgr protein
U876_13605	COG3501	Rhs element vgr protein
U876_13635	COG1435	thymidine kinase activity
U876_13640	COG1757	Na H antiporter
U876_13645	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_13650	COG2096	Adenosyltransferase
U876_13655	COG3530	Putative quorum-sensing-regulated virulence factor
U876_13660	COG0602	queuosine metabolic process
U876_13665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U876_13685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
U876_13695	COG0776	regulation of translation
U876_13700	COG0539	negative regulation of cytoplasmic translation
U876_13705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
U876_13710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U876_13720	COG0583	DNA-binding transcription factor activity
U876_13740	COG0778	Nitroreductase
U876_13745	COG5001	Diguanylate cyclase
U876_13745	COG3300	MHYT domain
U876_13755	COG0583	DNA-binding transcription factor activity
U876_13760	COG3437	response regulator, receiver
U876_13785	COG4989	oxidoreductase activity
U876_13790	COG0724	RNA recognition motif
U876_13810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U876_13825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_13830	COG1360	Flagellar Motor Protein
U876_13835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_13840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_13845	COG0649	NAD binding
U876_13845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_13860	COG1034	ATP synthesis coupled electron transport
U876_13865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
U876_13870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_13875	COG0839	Belongs to the complex I subunit 6 family
U876_13880	COG0713	ATP synthesis coupled electron transport
U876_13890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_13895	COG1007	ATP synthesis coupled electron transport
U876_13905	COG0047	phosphoribosylformylglycinamidine synthase activity
U876_13905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U876_13910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
U876_13915	COG1645	bacterial-type flagellum-dependent swarming motility
U876_13920	COG1160	GTP binding
U876_13925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_13930	COG2976	Protein conserved in bacteria
U876_13935	COG0124	histidyl-tRNA synthetase
U876_13940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
U876_13955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U876_13960	COG0105	UTP biosynthetic process
U876_13965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_13975	COG0633	Ferredoxin
U876_13980	COG0443	Heat shock 70 kDa protein
U876_13985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U876_13995	COG0822	iron-sulfur transferase activity
U876_14000	COG1104	cysteine desulfurase activity
U876_14045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_14050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_14055	COG1862	Preprotein translocase
U876_14060	COG0343	queuine tRNA-ribosyltransferase activity
U876_14065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
U876_14070	COG0517	IMP dehydrogenase activity
U876_14075	COG0450	alkyl hydroperoxide reductase
U876_14080	COG3634	alkyl hydroperoxide reductase activity
U876_14085	COG2814	Major facilitator Superfamily
U876_14100	COG1393	Belongs to the ArsC family
U876_14105	COG0798	PFAM Bile acid sodium symporter
U876_14110	COG0640	Transcriptional regulator
U876_14115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U876_14115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U876_14120	COG0509	glycine decarboxylation via glycine cleavage system
U876_14125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
U876_14130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_14135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_14150	COG2814	Major facilitator Superfamily
U876_14155	COG0625	glutathione transferase activity
U876_14165	COG0483	inositol monophosphate 1-phosphatase activity
U876_14185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U876_14200	COG1086	Polysaccharide biosynthesis protein
U876_14220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U876_14230	COG2089	acid synthase
U876_14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_14305	COG0301	tRNA thio-modification
U876_14315	COG4953	penicillin-binding protein 1C
U876_14320	COG2373	Large extracellular alpha-helical protein
U876_14325	COG1473	amidohydrolase
U876_14330	COG0628	permease
U876_14335	COG1538	Outer membrane efflux protein
U876_14340	COG1566	PFAM secretion protein HlyD family protein
U876_14355	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_14365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_14380	COG4215	(ABC) transporter
U876_14385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_14395	COG2431	L-lysine efflux transmembrane transporter activity
U876_14400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_14405	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
U876_14425	COG1393	Belongs to the ArsC family
U876_14435	COG4783	chaperone-mediated protein folding
U876_14465	COG3842	ATPase activity
U876_14475	COG1175	transmembrane transport
U876_14485	COG3081	Nucleoid-associated protein
U876_14490	COG3082	Protein of unknown function (DUF1414)
U876_14495	COG3083	sulfuric ester hydrolase activity
U876_14500	COG4771	TonB-dependent receptor
U876_14505	COG1770	oligopeptidase
U876_14525	COG4574	serine-type endopeptidase inhibitor activity
U876_14530	COG3085	chromosome segregation
U876_14535	COG0583	DNA-binding transcription factor activity
U876_14540	COG1605	Chorismate mutase
U876_14540	COG0287	Prephenate dehydrogenase
U876_14545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_14550	COG0584	glycerophosphoryl diester phosphodiesterase
U876_14560	COG1349	DNA-binding transcription factor activity
U876_14565	COG2271	Major facilitator Superfamily
U876_14570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U876_14575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
U876_14580	COG0583	DNA-binding transcription factor activity
U876_14600	COG0656	L-ascorbic acid biosynthetic process
U876_14605	COG2814	Major facilitator Superfamily
U876_14615	COG1294	oxidase, subunit
U876_14625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_14635	COG2979	Protein of unknown function (DUF533)
U876_14660	COG2271	Major facilitator Superfamily
U876_14665	COG0583	DNA-binding transcription factor activity
U876_14675	COG2807	transmembrane transport
U876_14680	COG1187	pseudouridine synthase activity
U876_14710	COG1061	Type III restriction enzyme res subunit
U876_14720	COG2964	Protein conserved in bacteria
U876_14725	COG3681	Belongs to the UPF0597 family
U876_14735	COG0814	amino acid
U876_14755	COG1166	arginine decarboxylase activity
U876_14760	COG2195	Cleaves the N-terminal amino acid of tripeptides
U876_14790	COG0583	DNA-binding transcription factor activity
U876_14800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
U876_14805	COG0840	transmembrane signaling receptor activity
U876_14810	COG0302	gtp cyclohydrolase
U876_14820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U876_14825	COG2267	carboxylic ester hydrolase activity
U876_14830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
U876_14845	COG0314	molybdopterin synthase activity
U876_14850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U876_14855	COG0315	cyclic pyranopterin monophosphate synthase activity
U876_14860	COG0521	Mo-molybdopterin cofactor biosynthetic process
U876_14865	COG3005	denitrification pathway
U876_14875	COG0348	domain, Protein
U876_14880	COG0437	4 iron, 4 sulfur cluster binding
U876_14885	COG0243	molybdopterin cofactor binding
U876_14900	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_14900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_14905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U876_14910	COG3850	Histidine kinase
U876_14915	COG2197	response regulator
U876_14945	COG0121	glutamine amidotransferase
U876_14950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U876_14960	COG1960	acyl-CoA dehydrogenase activity
U876_14970	COG3437	response regulator, receiver
U876_14970	COG0784	Response regulator, receiver
U876_14980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_14985	COG0328	RNA-DNA hybrid ribonuclease activity
U876_14990	COG2226	methyltransferase
U876_14995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U876_15000	COG1388	LysM domain
U876_15000	COG0741	lytic transglycosylase activity
U876_15005	COG3021	interspecies interaction between organisms
U876_15015	COG1607	acyl-coa hydrolase
U876_15030	COG0741	lytic transglycosylase activity
U876_15040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U876_15065	COG0729	surface antigen
U876_15075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U876_15080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U876_15090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U876_15100	COG4134	Bacterial extracellular solute-binding protein
U876_15110	COG4136	ATPase activity
U876_15115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U876_15120	COG2951	lytic endotransglycosylase activity
U876_15125	COG1846	Transcriptional regulator
U876_15135	COG0033	Phosphoglucomutase
U876_15140	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
U876_15145	COG0596	Alpha beta hydrolase
U876_15160	COG0716	FMN binding
U876_15170	COG0735	belongs to the Fur family
U876_15175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_15185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_15185	COG1263	PTS System
U876_15185	COG2190	(PTS) system
U876_15190	COG0363	glucosamine-6-phosphate deaminase activity
U876_15195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_15200	COG1940	carbohydrate kinase activity
U876_15200	COG1846	Transcriptional regulator
U876_15210	COG2194	sulfuric ester hydrolase activity
U876_15215	COG0217	transcriptional regulatory protein
U876_15220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U876_15225	COG1801	Protein of unknown function DUF72
U876_15230	COG4106	trans-aconitate 2-methyltransferase activity
U876_15235	COG0500	methyltransferase
U876_15255	COG0450	alkyl hydroperoxide reductase
U876_15260	COG0583	DNA-binding transcription factor activity
U876_15270	COG0791	NLP P60 protein
U876_15285	COG1309	transcriptional regulator
U876_15325	COG0534	Mate efflux family protein
U876_15345	COG2366	antibiotic biosynthetic process
U876_15350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U876_15350	COG0674	pyruvate-flavodoxin oxidoreductase activity
U876_15350	COG1013	pyruvate-flavodoxin oxidoreductase activity
U876_15350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
U876_15360	COG0633	Ferredoxin
U876_15360	COG0633	Ferredoxin
U876_15360	COG3217	Mosc domain protein beta barrel domain protein
U876_15360	COG3217	Mosc domain protein beta barrel domain protein
U876_15370	COG0501	Belongs to the peptidase M48B family
U876_15375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U876_15380	COG2226	methyltransferase
U876_15380	COG1073	alpha beta
U876_15385	COG0156	8-amino-7-oxononanoate synthase activity
U876_15390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U876_15410	COG0017	Asparaginyl-tRNA synthetase
U876_15415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U876_15430	COG3069	C4-dicarboxylate transmembrane transporter activity
U876_15440	COG0583	DNA-binding transcription factor activity
U876_15445	COG1393	Belongs to the ArsC family
U876_15450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U876_15455	COG1876	peptidase activity
U876_15465	COG3263	regulation of cellular component size
U876_15485	COG1280	lysine exporter protein (LysE YggA)
U876_15510	COG1957	nucleoside hydrolase
U876_15515	COG0564	pseudouridine synthase activity
U876_15525	COG1454	alcohol dehydrogenase
U876_15575	COG4964	Belongs to the GSP D family
U876_15605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_15610	COG0702	epimerase
U876_15620	COG2867	negative regulation of translational initiation
U876_15625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
U876_15700	COG4397	Mu-like prophage major head subunit gpT
U876_15705	COG4388	Caudovirus prohead serine protease
U876_15725	COG4383	Mu-like prophage protein gp29
U876_15730	COG4373	Mu-like prophage FluMu protein gp28
U876_15740	COG0640	Transcriptional regulator
U876_15780	COG5566	PFAM Mor transcription activator
U876_15885	COG0583	DNA-binding transcription factor activity
U876_15890	COG2610	gluconate transmembrane transporter activity
U876_15895	COG3048	D-serine ammonia-lyase activity
U876_15905	COG0538	isocitrate dehydrogenase activity
U876_15910	COG2207	Transcriptional regulator
U876_15930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_15940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U876_15945	COG1263	PTS System
U876_15945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_15950	COG1609	Transcriptional regulator
U876_15965	COG0456	acetyltransferase
U876_15985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_15985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_15985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_15995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_16005	COG1187	pseudouridine synthase activity
U876_16015	COG0482	sulfurtransferase activity
U876_16020	COG2915	High frequency lysogenization protein hflD homolog
U876_16025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U876_16030	COG2850	peptidyl-arginine hydroxylation
U876_16040	COG3153	acetyltransferase
U876_16050	COG0625	glutathione transferase activity
U876_16055	COG0259	pyridoxamine-phosphate oxidase activity
U876_16070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_16070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_16075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
U876_16090	COG3088	subunit of a heme lyase
U876_16090	COG4235	cytochrome complex assembly
U876_16095	COG4235	cytochrome complex assembly
U876_16095	COG3088	subunit of a heme lyase
U876_16100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U876_16105	COG1138	Cytochrome C-type biogenesis protein
U876_16110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
U876_16115	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_16120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_16125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_16140	COG0835	chemotaxis
U876_16150	COG1192	Involved in chromosome partitioning
U876_16155	COG1360	Flagellar Motor Protein
U876_16160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_16165	COG2201	protein-glutamate methylesterase activity
U876_16170	COG2198	Histidine kinase
U876_16170	COG0643	Histidine kinase
U876_16175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
U876_16190	COG0455	bacterial-type flagellum organization
U876_16200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U876_16210	COG1684	flagellar biosynthetic protein fliR
U876_16215	COG1987	bacterial-type flagellum assembly
U876_16265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U876_16275	COG1677	Flagellar hook-basal body complex protein FliE
U876_16290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U876_16300	COG1073	alpha beta
U876_16300	COG3064	Membrane
U876_16300	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
U876_16315	COG2274	protein secretion by the type I secretion system
U876_16325	COG2274	protein secretion by the type I secretion system
U876_16330	COG0745	RESPONSE REGULATOR receiver
U876_16345	COG1737	Transcriptional regulator
U876_16350	COG0469	pyruvate kinase activity
U876_16360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_16365	COG1960	acyl-CoA dehydrogenase activity
U876_16375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U876_16385	COG0243	molybdopterin cofactor binding
U876_16390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U876_16395	COG0583	DNA-binding transcription factor activity
U876_16415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U876_16420	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U876_16425	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U876_16430	COG1454	alcohol dehydrogenase
U876_16430	COG1012	belongs to the aldehyde dehydrogenase family
U876_16440	COG1012	belongs to the aldehyde dehydrogenase family
U876_16440	COG1454	alcohol dehydrogenase
U876_16445	COG1882	Formate acetyltransferase
U876_16450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_16455	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U876_16460	COG4869	propanediol catabolic process
U876_16505	COG2731	YhcH YjgK YiaL family protein
U876_16510	COG2826	transposase and inactivated derivatives, IS30 family
U876_16515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_16525	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
U876_16530	COG1737	Transcriptional regulator
U876_16535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U876_16540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
U876_16545	COG1349	DNA-binding transcription factor activity
U876_16550	COG0738	Major facilitator superfamily
U876_16560	COG1070	Carbohydrate kinase
U876_16580	COG4172	Belongs to the ABC transporter superfamily
U876_16585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_16595	COG0747	negative chemotaxis
U876_16605	COG1388	LysM domain
U876_16605	COG1376	ErfK ybiS ycfS ynhG family protein
U876_16620	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
U876_16625	COG0791	NLP P60 protein
U876_16630	COG2091	lysine biosynthetic process via aminoadipic acid
U876_16635	COG3118	belongs to the thioredoxin family
U876_16645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U876_16650	COG0788	formyltetrahydrofolate deformylase activity
U876_16660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_16680	COG0366	Alpha amylase catalytic
U876_16685	COG0739	heme binding
U876_16685	COG0741	lytic transglycosylase activity
U876_16685	COG1196	nuclear chromosome segregation
U876_16690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U876_16695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
U876_16705	COG0673	inositol 2-dehydrogenase activity
U876_16725	COG1032	radical SAM domain protein
U876_16735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_16740	COG1566	PFAM secretion protein HlyD family protein
U876_16745	COG2203	Gaf domain
U876_16745	COG2199	diguanylate cyclase activity
U876_16750	COG1752	Esterase of the alpha-beta hydrolase superfamily
U876_16755	COG0733	neurotransmitter:sodium symporter activity
U876_16785	COG0281	malic enzyme
U876_16795	COG0534	Mate efflux family protein
U876_16805	COG0745	RESPONSE REGULATOR receiver
U876_16805	COG3706	GGDEF domain
U876_16810	COG2233	PERMEase
U876_16815	COG0095	Lipoate-protein ligase
U876_16820	COG1115	amino acid carrier protein
U876_16825	COG0019	diaminopimelate decarboxylase activity
U876_16835	COG0678	peroxiredoxin activity
U876_16845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
U876_16865	COG1131	(ABC) transporter
U876_16870	COG0545	Peptidyl-prolyl cis-trans isomerase
U876_16875	COG3142	Participates in the control of copper homeostasis
U876_16890	COG4783	chaperone-mediated protein folding
U876_16900	COG5002	protein histidine kinase activity
U876_16905	COG0745	RESPONSE REGULATOR receiver
U876_16910	COG0346	lactoylglutathione lyase activity
U876_16915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
U876_16920	COG1960	acyl-CoA dehydrogenase activity
U876_16925	COG3284	Transcriptional regulator
U876_16930	COG1012	belongs to the aldehyde dehydrogenase family
U876_16940	COG0697	spore germination
U876_16945	COG4565	transcriptional regulatory protein
U876_16950	COG3290	protein histidine kinase activity
U876_16955	COG0281	malic enzyme
U876_16970	COG1846	Transcriptional regulator
U876_16975	COG1566	PFAM secretion protein HlyD family protein
U876_17005	COG0602	queuosine metabolic process
U876_17010	COG1328	CTP reductase activity
U876_17020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U876_17025	COG3115	cell septum assembly
U876_17030	COG1196	nuclear chromosome segregation
U876_17040	COG2860	membrane
U876_17050	COG3108	Peptidase M15
U876_17055	COG2989	Protein conserved in bacteria
U876_17070	COG0463	Glycosyl transferase, family 2
U876_17085	COG0366	Alpha amylase catalytic
U876_17120	COG3706	GGDEF domain
U876_17125	COG0037	tRNA processing
U876_17130	COG3590	peptidase
U876_17140	COG0488	(ABC) transporter
U876_17150	COG0531	amino acid
U876_17165	COG0814	amino acid
U876_17180	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
U876_17185	COG1982	Orn Lys Arg decarboxylase major
U876_17190	COG0531	amino acid
U876_17195	COG3710	Transcriptional regulator
U876_17200	COG0825	malonyl-CoA metabolic process
U876_17210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U876_17215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_17220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_17225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U876_17230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_17245	COG0750	zinc metalloprotease
U876_17255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U876_17260	COG0575	Belongs to the CDS family
U876_17270	COG0233	cytoplasmic translational termination
U876_17275	COG0528	UMP kinase activity
U876_17280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
U876_17285	COG0052	Belongs to the universal ribosomal protein uS2 family
U876_17290	COG0024	Methionine aminopeptidase
U876_17295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
U876_17300	COG2171	N-acyltransferase activity
U876_17310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_17310	COG1263	PTS System
U876_17320	COG4580	involved in the transport of maltose and maltodextrins
U876_17330	COG0564	pseudouridine synthase activity
U876_17335	COG3098	single-species biofilm formation
U876_17360	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
U876_17370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U876_17370	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U876_17380	COG3706	GGDEF domain
U876_17385	COG1611	Belongs to the LOG family
U876_17390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_17395	COG0473	3-isopropylmalate dehydrogenase activity
U876_17405	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
U876_17410	COG2363	Small membrane protein
U876_17420	COG0583	DNA-binding transcription factor activity
U876_17425	COG0840	transmembrane signaling receptor activity
U876_17430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_17445	COG1477	protein flavinylation
U876_17450	COG2871	sodium ion transport
U876_17455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_17460	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_17465	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_17470	COG1805	sodium ion transport
U876_17475	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_17480	COG0271	Belongs to the BolA IbaG family
U876_17485	COG2813	Specifically methylates the guanine in position
U876_17495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U876_17505	COG2211	Major facilitator Superfamily
U876_17510	COG3248	Nucleoside-binding outer membrane protein
U876_17515	COG1666	GTP binding
U876_17520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U876_17525	COG0693	protein deglycase activity
U876_17560	COG3501	Rhs element vgr protein
U876_17570	COG2771	luxR family
U876_17580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_17580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_17585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U876_17595	COG1151	hydroxylamine reductase activity
U876_17600	COG0783	Belongs to the Dps family
U876_17625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
U876_17640	COG4221	oxidoreductase activity
U876_17650	COG0415	Belongs to the DNA photolyase family
U876_17655	COG0789	Transcriptional regulator
U876_17660	COG3272	Protein of unknown function (DUF1722)
U876_17690	COG1605	Chorismate mutase
U876_17690	COG0077	Prephenate dehydratase
U876_17740	COG3501	Rhs element vgr protein
U876_17835	COG2003	Belongs to the UPF0758 family
U876_17920	COG2826	transposase and inactivated derivatives, IS30 family
U876_17940	COG5377	YqaJ viral recombinase family
U876_17985	COG2003	Belongs to the UPF0758 family
U876_17995	COG0602	queuosine metabolic process
U876_18000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U876_18040	COG0514	ATP-dependent DNA helicase (RecQ)
U876_18045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U876_18070	COG4771	TonB-dependent receptor
U876_18090	COG1116	anion transmembrane transporter activity
U876_18130	COG2226	methyltransferase
U876_18165	COG2133	pyrroloquinoline quinone binding
U876_18175	COG0840	transmembrane signaling receptor activity
U876_18185	COG0300	oxidoreductase activity
U876_18210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
U876_18225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U876_18230	COG0826	peptidase U32
U876_18235	COG1280	lysine exporter protein (LysE YggA)
U876_18250	COG0840	transmembrane signaling receptor activity
U876_18255	COG0745	RESPONSE REGULATOR receiver
U876_18265	COG0643	Histidine kinase
U876_18265	COG2198	Histidine kinase
U876_18275	COG0835	chemotaxis
U876_18280	COG0840	transmembrane signaling receptor activity
U876_18290	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U876_18295	COG2201	protein-glutamate methylesterase activity
U876_18300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U876_18330	COG2200	EAL domain
U876_18330	COG2203	Gaf domain
U876_18330	COG2199	diguanylate cyclase activity
U876_18340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_18350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_18355	COG0305	Participates in initiation and elongation during chromosome replication
U876_18370	COG2200	EAL domain
U876_18375	COG0737	Belongs to the 5'-nucleotidase family
U876_18395	COG2204	response regulator
U876_18400	COG0545	Peptidyl-prolyl cis-trans isomerase
U876_18410	COG2900	Belongs to the SlyX family
U876_18415	COG1047	Peptidyl-prolyl cis-trans
U876_18420	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
U876_18430	COG0784	Response regulator, receiver
U876_18430	COG0835	chemotaxis
U876_18435	COG0429	hydrolase of the alpha beta-hydrolase fold
U876_18440	COG5001	Diguanylate cyclase
U876_18440	COG4251	negative regulation of phosphorylation
U876_18440	COG2203	Gaf domain
U876_18440	COG3706	GGDEF domain
U876_18445	COG3089	Belongs to the UPF0270 family
U876_18455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U876_18460	COG0463	Glycosyl transferase, family 2
U876_18465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U876_18465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U876_18470	COG0726	polysaccharide deacetylase
U876_18475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U876_18480	COG2076	Multidrug Resistance protein
U876_18485	COG2076	Multidrug Resistance protein
U876_18490	COG3954	Phosphoribulokinase
U876_18505	COG1765	OsmC-like protein
U876_18510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U876_18515	COG2226	methyltransferase
U876_18520	COG3397	chitin binding
U876_18535	COG2202	Pas domain
U876_18535	COG2205	protein histidine kinase activity
U876_18545	COG3655	Transcriptional regulator
U876_18550	COG2814	Major facilitator Superfamily
U876_18555	COG4771	TonB-dependent receptor
U876_18575	COG0748	coenzyme F420 binding
U876_18580	COG3721	Heme iron utilization protein
U876_18590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_18615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U876_18620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_18625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
U876_18645	COG0741	lytic transglycosylase activity
U876_18650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U876_18750	COG0616	signal peptide processing
U876_18765	COG4626	Terminase
U876_18765	COG1802	Transcriptional regulator
U876_18805	COG0464	growth
U876_18940	COG0582	viral genome integration into host DNA
U876_18945	COG0488	(ABC) transporter
U876_18955	COG2252	PERMEase
U876_18960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U876_18965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U876_18975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U876_18985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
U876_18990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
U876_19000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U876_19010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U876_19015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_19030	COG0318	PFAM AMP-dependent synthetase and ligase
U876_19040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
U876_19045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
U876_19050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
U876_19055	COG0142	geranyltranstransferase activity
U876_19060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
U876_19065	COG0330	HflC and HflK could
U876_19070	COG0330	HflC and HflK could
U876_19075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U876_19080	COG1923	regulation of RNA biosynthetic process
U876_19085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
U876_19090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
U876_19105	COG0802	atpase or kinase
U876_19110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
U876_19110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U876_19130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U876_19135	COG2011	ABC-type metal ion transport system permease component
U876_19140	COG1464	Belongs to the NlpA lipoprotein family
U876_19150	COG0840	transmembrane signaling receptor activity
U876_19175	COG5002	protein histidine kinase activity
U876_19175	COG2198	Histidine kinase
U876_19175	COG0784	Response regulator, receiver
U876_19195	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
U876_19210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
U876_19215	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
U876_19225	COG2716	regulation of RNA biosynthetic process
U876_19230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U876_19235	COG3013	Belongs to the UPF0304 family
U876_19240	COG3092	negative regulation of chromosome organization
U876_19245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U876_19250	COG0280	phosphate acetyltransferase
U876_19250	COG0857	belongs to the CobB CobQ family
U876_19260	COG0028	Belongs to the TPP enzyme family
U876_19275	COG0671	phosphoesterase, PA-phosphatase related
U876_19285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U876_19290	COG0473	3-isopropylmalate dehydrogenase activity
U876_19295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
U876_19300	COG0066	3-isopropylmalate dehydratase activity
U876_19315	COG4143	(ABC) transporter
U876_19320	COG1178	ABC-type Fe3 transport system permease component
U876_19325	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
U876_19330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
U876_19340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_19370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U876_19375	COG0564	pseudouridine synthase activity
U876_19385	COG3300	MHYT domain
U876_19385	COG5001	Diguanylate cyclase
U876_19395	COG0459	protein refolding
U876_19400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
U876_19405	COG0534	Mate efflux family protein
U876_19410	COG3030	protein affecting phage T7 exclusion by the F plasmid
U876_19415	COG1027	Aspartate ammonia-lyase
U876_19420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U876_19430	COG0477	Major facilitator Superfamily
U876_19455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U876_19465	COG0673	inositol 2-dehydrogenase activity
U876_19475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U876_19480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U876_19485	COG3036	rescue of stalled ribosome
U876_19490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U876_19500	COG0138	bifunctional purine biosynthesis protein purh
U876_19505	COG0151	Belongs to the GarS family
U876_19535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U876_19540	COG0358	DNA primase activity
U876_19545	COG1610	YqeY-like protein
U876_19550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
U876_19555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
U876_19570	COG1238	metal cluster binding
U876_19575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
U876_19580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
U876_19585	COG0585	pseudouridine synthase activity
U876_19595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U876_19600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
U876_19605	COG0148	phosphopyruvate hydratase activity
U876_19610	COG0504	CTP synthase activity
U876_19615	COG3956	TIGRFAM MazG family protein
U876_19620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U876_19625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_19635	COG4807	Protein conserved in bacteria
U876_19640	COG3023	N-Acetylmuramoyl-L-alanine amidase
U876_19645	COG1349	DNA-binding transcription factor activity
U876_19655	COG2222	sugar isomerase
U876_19660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_19670	COG3716	PTS system mannose fructose sorbose family IID component
U876_19675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_19680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_19695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
U876_19700	COG1381	Involved in DNA repair and RecF pathway recombination
U876_19710	COG0571	ribonuclease III activity
U876_19715	COG0681	Belongs to the peptidase S26 family
U876_19720	COG0481	GTPase activity
U876_19740	COG1595	DNA-templated transcription, initiation
U876_19745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U876_19755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
U876_19760	COG0354	folic acid binding
U876_19795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_19800	COG0191	fructose-bisphosphate aldolase activity
U876_19805	COG0126	phosphoglycerate kinase activity
U876_19810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U876_19815	COG1940	carbohydrate kinase activity
U876_19820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
U876_19835	COG4991	sh3 domain protein
U876_19840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U876_19855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
U876_19875	COG1505	serine-type exopeptidase activity
U876_19880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U876_19885	COG0765	amino acid transport
U876_19890	COG0765	amino acid transport
U876_19895	COG1126	abc transporter atp-binding protein
U876_19900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_19905	COG1136	(ABC) transporter
U876_19905	COG0577	efflux transmembrane transporter activity
U876_19910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_19915	COG0745	RESPONSE REGULATOR receiver
U876_19920	COG2205	protein histidine kinase activity
U876_19955	COG2070	2-Nitropropane dioxygenase
U876_19980	COG1858	cytochrome C peroxidase
U876_19985	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
U876_20005	COG0513	Belongs to the DEAD box helicase family
U876_20035	COG0154	amidase activity
U876_20040	COG2957	Belongs to the agmatine deiminase family
U876_20055	COG1902	pentaerythritol trinitrate reductase activity
U876_20085	COG3706	GGDEF domain
U876_20085	COG0745	RESPONSE REGULATOR receiver
U876_20090	COG5001	Diguanylate cyclase
U876_20100	COG0714	Associated with various cellular activities
U876_20110	COG0456	acetyltransferase
U876_20120	COG1022	Amp-dependent synthetase and ligase
U876_20130	COG2918	glutathione biosynthetic process
U876_20135	COG0612	Peptidase, M16
U876_20140	COG1238	metal cluster binding
U876_20165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_20170	COG0359	binds to the 23S rRNA
U876_20175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
U876_20180	COG0360	Binds together with S18 to 16S ribosomal RNA
U876_20185	COG1914	H( )-stimulated, divalent metal cation uptake system
U876_20205	COG2153	protein acetylation
U876_20215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U876_20220	COG0557	exoribonuclease II activity
U876_20225	COG3706	GGDEF domain
U876_20230	COG1854	S-ribosylhomocysteine lyase activity
U876_20245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U876_20245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U876_20305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
U876_20310	COG1047	Peptidyl-prolyl cis-trans
U876_20315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U876_20320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U876_20325	COG0196	riboflavin kinase activity
U876_20330	COG0728	peptidoglycan biosynthetic process
U876_20335	COG0268	Binds directly to 16S ribosomal RNA
U876_20340	COG0640	Transcriptional regulator
U876_20345	COG0583	DNA-binding transcription factor activity
U876_20355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_20360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U876_20365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
U876_20375	COG1051	belongs to the nudix hydrolase family
U876_20380	COG3066	DNA modification
U876_20390	COG0335	large ribosomal subunit rRNA binding
U876_20395	COG0336	Belongs to the RNA methyltransferase TrmD family
U876_20400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U876_20405	COG0228	four-way junction DNA binding
U876_20410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U876_20415	COG4137	Cytochrome C assembly protein
U876_20420	COG4536	flavin adenine dinucleotide binding
U876_20430	COG1017	nitric oxide dioxygenase activity
U876_20430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_20435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U876_20440	COG0039	L-malate dehydrogenase activity
U876_20445	COG4160	amino acid transport
U876_20450	COG4215	(ABC) transporter
U876_20455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_20460	COG1126	abc transporter atp-binding protein
U876_20465	COG1438	arginine binding
U876_20470	COG2837	iron assimilation
U876_20475	COG3842	ATPase activity
U876_20485	COG1840	ABC-type Fe3 transport system, periplasmic component
U876_20490	COG0347	Belongs to the P(II) protein family
U876_20505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_20510	COG0583	DNA-binding transcription factor activity
U876_20525	COG1929	Belongs to the glycerate kinase type-1 family
U876_20530	COG2610	gluconate transmembrane transporter activity
U876_20535	COG3835	regulator
U876_20545	COG3112	Uncharacterised protein family (UPF0231)
U876_20560	COG0840	transmembrane signaling receptor activity
U876_20565	COG3568	Endonuclease Exonuclease Phosphatase
U876_20580	COG0513	Belongs to the DEAD box helicase family
U876_20620	COG1448	Aminotransferase
U876_20635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_20640	COG1328	CTP reductase activity
U876_20660	COG0793	Belongs to the peptidase S41A family
U876_20660	COG4946	Tricorn protease homolog
U876_20690	COG0840	transmembrane signaling receptor activity
U876_20695	COG3397	chitin binding
U876_20700	COG0583	DNA-binding transcription factor activity
U876_20710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U876_20715	COG4208	sulfate ABC transporter
U876_20720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
U876_20730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
U876_20735	COG3174	membrane
U876_20740	COG0110	maltose O-acetyltransferase activity
U876_20765	COG0165	Argininosuccinate lyase
U876_20770	COG0137	argininosuccinate synthase activity
U876_20780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U876_20785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U876_20795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
U876_20805	COG0527	aspartate kinase activity
U876_20805	COG0460	homoserine dehydrogenase
U876_20810	COG0626	cystathionine gamma-synthase activity
U876_20820	COG3708	Transcriptional regulator
U876_20820	COG2207	Transcriptional regulator
U876_20825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_20830	COG0814	amino acid
U876_20835	COG1218	3'(2'),5'-bisphosphate nucleotidase
U876_20840	COG0494	nUDIX hydrolase
U876_20845	COG1011	Hydrolase
U876_20850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U876_20865	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
U876_20875	COG3156	type II secretion system protein K
U876_20880	COG4795	General secretion pathway protein
U876_20885	COG2165	general secretion pathway protein
U876_20900	COG2165	general secretion pathway protein
U876_20905	COG1459	type II secretion system
U876_20910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_20920	COG3031	protein transport across the cell outer membrane
U876_20930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
U876_20955	COG0456	acetyltransferase
U876_20960	COG3133	Outer membrane lipoprotein
U876_20975	COG2771	luxR family
U876_20980	COG3916	Acyl-homoserine-lactone synthase
U876_20990	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
U876_20995	COG1309	transcriptional regulator
U876_21010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_21010	COG2213	PTS system mannitol-specific
U876_21015	COG0246	Mannitol dehydrogenase
U876_21020	COG3722	fumarate hydratase activity
U876_21025	COG3263	regulation of cellular component size
U876_21050	COG1671	Belongs to the UPF0178 family
U876_21065	COG1988	membrane-bound metal-dependent
U876_21070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_21075	COG0513	Belongs to the DEAD box helicase family
U876_21100	COG1575	Belongs to the MenA family. Type 1 subfamily
U876_21105	COG1169	isochorismate synthase
U876_21110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
U876_21115	COG0596	Alpha beta hydrolase
U876_21120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
U876_21125	COG1441	menaquinone biosynthetic process
U876_21130	COG0318	PFAM AMP-dependent synthetase and ligase
U876_21145	COG3539	Fimbrial protein
U876_21150	COG3121	Chaperone
U876_21155	COG3188	usher protein
U876_21165	COG3539	Fimbrial protein
U876_21175	COG3291	Pkd domain containing protein
U876_21180	COG2949	membrane
U876_21195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U876_21200	COG5380	lipid catabolic process
U876_21215	COG4533	DNA binding
U876_21225	COG2873	o-acetylhomoserine
U876_21235	COG1979	alcohol dehydrogenase
U876_21255	COG4221	oxidoreductase activity
U876_21275	COG1285	pathogenesis
U876_21295	COG1368	sulfuric ester hydrolase activity
U876_21300	COG1522	sequence-specific DNA binding
U876_21310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
U876_21315	COG1418	mRNA catabolic process
U876_21320	COG1546	Belongs to the CinA family
U876_21320	COG1058	Belongs to the CinA family
U876_21335	COG0842	Transport permease protein
U876_21335	COG1129	ABC transporter
U876_21350	COG0561	phosphatase activity
U876_21355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
U876_21375	COG1011	Hydrolase
U876_21390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U876_21395	COG0019	diaminopimelate decarboxylase activity
U876_21400	COG1965	Belongs to the frataxin family
U876_21405	COG0400	carboxylic ester hydrolase activity
U876_21410	COG3072	Adenylate cyclase
U876_21415	COG0181	hydroxymethylbilane synthase activity
U876_21425	COG2959	enzyme of heme biosynthesis
U876_21440	COG1494	fructose-1,6-bisphosphatase
U876_21480	COG1733	regulation of RNA biosynthetic process
U876_21500	COG3932	Exopolysaccharide synthesis, ExoD
U876_21505	COG0814	amino acid
U876_21510	COG3706	GGDEF domain
U876_21525	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
U876_21540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U876_21545	COG2022	thiamine diphosphate biosynthetic process
U876_21555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U876_21560	COG0352	thiamine-phosphate diphosphorylase activity
U876_21565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
U876_21585	COG0745	RESPONSE REGULATOR receiver
U876_21595	COG1114	Component of the transport system for branched-chain amino acids
U876_21600	COG0189	ligase activity
U876_21645	COG3171	Protein conserved in bacteria
U876_21660	COG3188	usher protein
U876_21715	COG1639	'signal transduction protein
U876_21725	COG2321	neutral zinc metallopeptidase
U876_21730	COG3700	Belongs to the class B bacterial acid phosphatase family
U876_21750	COG1366	Belongs to the anti-sigma-factor antagonist family
U876_21755	COG2172	sigma factor antagonist activity
U876_21760	COG0784	Response regulator, receiver
U876_21760	COG5002	protein histidine kinase activity
U876_21760	COG2205	protein histidine kinase activity
U876_21765	COG3437	response regulator, receiver
U876_21775	COG0477	Major facilitator Superfamily
U876_21790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
U876_21795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_21795	COG1263	PTS System
U876_21815	COG0312	modulator of DNA gyrase
U876_21820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U876_21830	COG3164	Protein of unknown function
U876_21835	COG1530	ribonuclease E activity
U876_21840	COG0424	maF-like protein
U876_21845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U876_21850	COG1792	Involved in formation and maintenance of cell shape
U876_21855	COG1077	Cell shape determining protein MreB Mrl
U876_21880	COG4968	Prepilin-type N-terminal cleavage methylation domain
U876_21900	COG1459	type II secretion system
U876_21905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_21915	COG2842	Transposition protein
U876_21950	COG2200	EAL domain
U876_21950	COG2199	diguanylate cyclase activity
U876_21955	COG2200	EAL domain
U876_21960	COG0387	Pfam Sodium calcium exchanger
U876_21965	COG2986	histidine ammonia-lyase
U876_21970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
U876_21975	COG0010	Belongs to the arginase family
U876_21980	COG1228	amidohydrolase
U876_21985	COG2188	Transcriptional regulator
U876_21990	COG0288	reversible hydration of carbon dioxide
U876_22000	COG2177	Part of the ABC transporter FtsEX involved in
U876_22005	COG2884	Cell division ATP-binding protein ftsE
U876_22010	COG0552	protein localization to endoplasmic reticulum
U876_22015	COG0742	ribosomal rna small subunit methyltransferase
U876_22040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_22050	COG0741	lytic transglycosylase activity
U876_22075	COG2095	MarC family integral membrane protein
U876_22085	COG1301	dicarboxylic acid transport
U876_22110	COG3714	YhhN family
U876_22135	COG1770	oligopeptidase
U876_22150	COG4221	oxidoreductase activity
U876_22155	COG0583	DNA-binding transcription factor activity
U876_22160	COG2249	NAD(P)H dehydrogenase (quinone) activity
U876_22210	COG0203	ribosomal protein L17
U876_22215	COG0202	RNA polymerase activity
U876_22220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U876_22225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
U876_22230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
U876_22235	COG0201	protein transport
U876_22240	COG0200	Binds to the 23S rRNA
U876_22245	COG1841	ribosomal large subunit assembly
U876_22250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
U876_22255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
U876_22260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
U876_22265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
U876_22270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
U876_22275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
U876_22280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
U876_22285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
U876_22290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
U876_22295	COG0255	Belongs to the universal ribosomal protein uL29 family
U876_22300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
U876_22305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
U876_22310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
U876_22315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
U876_22320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U876_22325	COG0089	rRNA binding
U876_22330	COG0088	Forms part of the polypeptide exit tunnel
U876_22335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U876_22340	COG0051	transcription antitermination factor activity, RNA binding
U876_22355	COG0745	RESPONSE REGULATOR receiver
U876_22360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U876_22365	COG2183	response to ionizing radiation
U876_22385	COG0596	Alpha beta hydrolase
U876_22390	COG1040	competence protein
U876_22395	COG0316	Belongs to the HesB IscA family
U876_22395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
U876_22400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
U876_22405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
U876_22410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_22415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U876_22420	COG4942	peptidase
U876_22430	COG1609	Transcriptional regulator
U876_22435	COG0800	Aldolase
U876_22440	COG0129	dihydroxy-acid dehydratase activity
U876_22445	COG3265	gluconokinase activity
U876_22450	COG2610	gluconate transmembrane transporter activity
U876_22455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_22460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U876_22470	COG0456	acetyltransferase
U876_22480	COG1490	D-aminoacyl-tRNA deacylase activity
U876_22485	COG1295	ribonuclease BN
U876_22495	COG0174	glutamine synthetase
U876_22505	COG3852	Histidine kinase
U876_22510	COG2204	response regulator
U876_22515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
U876_22520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U876_22530	COG3078	GTPase activator activity
U876_22545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U876_22555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U876_22560	COG0408	coproporphyrinogen oxidase activity
U876_22565	COG0009	L-threonylcarbamoyladenylate synthase
U876_22575	COG0551	DNA topoisomerase type I activity
U876_22580	COG2922	Belongs to the Smg family
U876_22585	COG0758	DNA mediated transformation
U876_22595	COG0242	peptide deformylase activity
U876_22600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U876_22605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_22605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_22610	COG0569	domain protein
U876_22615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_22640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_22645	COG0686	Belongs to the AlaDH PNT family
U876_22650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U876_22650	COG0519	Catalyzes the synthesis of GMP from XMP
U876_22665	COG1396	sequence-specific DNA binding
U876_22670	COG1012	belongs to the aldehyde dehydrogenase family
U876_22680	COG2962	Rard protein
U876_22690	COG1280	lysine exporter protein (LysE YggA)
U876_22700	COG2391	methyltransferase activity
U876_22705	COG1280	lysine exporter protein (LysE YggA)
U876_22750	COG0583	DNA-binding transcription factor activity
U876_22755	COG1943	Transposase
U876_22765	COG0210	DNA helicase
U876_22795	COG0583	DNA-binding transcription factor activity
U876_22815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U876_22820	COG0385	Bile acid
U876_22825	COG0531	amino acid
U876_22830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_22835	COG0531	amino acid
U876_22840	COG2731	YhcH YjgK YiaL family protein
U876_22845	COG3250	beta-galactosidase activity
U876_22850	COG1609	Transcriptional regulator
U876_22885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U876_22890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_22890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_22895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
U876_22900	COG3074	FtsZ-dependent cytokinesis
U876_22910	COG1045	serine acetyltransferase
U876_22920	COG0745	RESPONSE REGULATOR receiver
U876_22925	COG2205	protein histidine kinase activity
U876_22930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U876_22935	COG0534	Mate efflux family protein
U876_22950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_22955	COG2937	Belongs to the GPAT DAPAT family
U876_22960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
U876_22965	COG3161	chorismate lyase activity
U876_22970	COG1580	Controls the rotational direction of flagella during chemotaxis
U876_22990	COG0604	alcohol dehydrogenase
U876_22995	COG1609	Transcriptional regulator
U876_23015	COG1519	Transferase
U876_23020	COG0859	PFAM glycosyl transferase family 9
U876_23025	COG0463	Glycosyl transferase, family 2
U876_23030	COG0859	PFAM glycosyl transferase family 9
U876_23035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
U876_23040	COG2990	Protein conserved in bacteria
U876_23045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
U876_23055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
U876_23060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
U876_23065	COG2003	Belongs to the UPF0758 family
U876_23070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U876_23075	COG0756	dUTP diphosphatase activity
U876_23080	COG1309	transcriptional regulator
U876_23085	COG0668	transmembrane transport
U876_23095	COG0166	Belongs to the GPI family
U876_23100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U876_23105	COG0583	DNA-binding transcription factor activity
U876_23145	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
U876_23150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_23155	COG1739	Uncharacterized protein family UPF0029
U876_23160	COG0006	proline dipeptidase activity
U876_23165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U876_23170	COG1024	Enoyl-CoA hydratase
U876_23170	COG1250	3-hydroxyacyl-CoA dehydrogenase
U876_23175	COG0183	Belongs to the thiolase family
U876_23180	COG0745	RESPONSE REGULATOR receiver
U876_23185	COG2205	protein histidine kinase activity
U876_23200	COG0425	Belongs to the sulfur carrier protein TusA family
U876_23205	COG0251	oxidation-reduction process
U876_23210	COG2885	chlorophyll binding
U876_23215	COG1335	isochorismatase
U876_23220	COG2818	Glycosylase
U876_23225	COG0752	glycyl-tRNA synthetase alpha subunit
U876_23230	COG0751	glycine-tRNA ligase activity
U876_23245	COG0529	Catalyzes the synthesis of activated sulfate
U876_23245	COG2046	Belongs to the sulfate adenylyltransferase family
U876_23265	COG0814	amino acid
U876_23270	COG0348	domain, Protein
U876_23280	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_23285	COG0426	domain, Protein
U876_23285	COG1773	rubredoxin
U876_23290	COG3604	Transcriptional regulator
U876_23295	COG2188	Transcriptional regulator
U876_23310	COG1609	Transcriptional regulator
U876_23320	COG0559	Belongs to the binding-protein-dependent transport system permease family
U876_23350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_23375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U876_23385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
U876_23390	COG3118	belongs to the thioredoxin family
U876_23395	COG0513	Belongs to the DEAD box helicase family
U876_23400	COG0248	Ppx GppA phosphatase
U876_23415	COG0742	ribosomal rna small subunit methyltransferase
U876_23435	COG0084	hydrolase, TatD family'
U876_23440	COG0805	protein transport
U876_23445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U876_23455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
U876_23460	COG3165	ubiquinone biosynthetic process from chorismate
U876_23470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U876_23475	COG0402	S-adenosylhomocysteine deaminase activity
U876_23515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
U876_23520	COG0848	biopolymer transport protein
U876_23525	COG0811	peptide transport
U876_23530	COG0811	peptide transport
U876_23540	COG2771	luxR family
U876_23545	COG5433	transposase activity
U876_23565	COG4771	TonB-dependent receptor
U876_23570	COG4133	protoheme IX ABC transporter activity
U876_23575	COG4107	phosphonate C-P lyase system protein PhnK
U876_23580	COG3627	carbon phosphorus lyase activity
U876_23585	COG3626	phosphonate metabolism
U876_23750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U876_23795	COG1192	Involved in chromosome partitioning
U876_23850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U876_23865	COG0776	regulation of translation
U876_23930	COG2336	PFAM SpoVT AbrB
U876_24095	COG1121	(ABC) transporter
U876_24120	COG3550	peptidyl-serine autophosphorylation
U876_24125	COG1396	sequence-specific DNA binding
U876_24130	COG4974	Belongs to the 'phage' integrase family
U876_24170	COG2963	transposase activity
U876_24175	COG2801	Transposase and inactivated derivatives
U876_24220	COG5433	transposase activity
U876_24240	COG4771	TonB-dependent receptor
U876_24245	COG4133	protoheme IX ABC transporter activity
U876_24250	COG4107	phosphonate C-P lyase system protein PhnK
U876_24255	COG3627	carbon phosphorus lyase activity
U876_24260	COG3626	phosphonate metabolism
U876_24340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U876_24345	COG1349	DNA-binding transcription factor activity
U876_24350	COG0745	RESPONSE REGULATOR receiver
U876_24355	COG2205	protein histidine kinase activity
U876_24365	COG4452	Inner membrane protein CreD
U876_24370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U876_24375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U876_24380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U876_24385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
U876_24390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U876_24395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U876_24400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U876_24410	COG0356	it plays a direct role in the translocation of protons across the membrane
U876_24420	COG1475	DNA binding
U876_24425	COG1192	Involved in chromosome partitioning
U876_24430	COG0357	Ribosomal RNA small subunit methyltransferase G
U876_24435	COG0445	tRNA wobble uridine modification
U876_24440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U876_24445	COG4774	siderophore transport
U876_24450	COG4615	Cyclic peptide transporter
U876_24455	COG1120	ATPase activity
U876_24470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U876_24475	COG0706	membrane insertase activity
U876_24480	COG0594	ribonuclease P activity
U876_24485	COG0230	Belongs to the bacterial ribosomal protein bL34 family