locus-tag	class	description
E4625_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4625_00010	COG0592	DNA-directed DNA polymerase activity
E4625_00020	COG0187	DNA topoisomerase II activity
E4625_00030	COG2378	regulation of single-species biofilm formation
E4625_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
E4625_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
E4625_00045	COG3977	Valine--pyruvate aminotransferase
E4625_00060	COG2814	Major facilitator Superfamily
E4625_00065	COG0745	RESPONSE REGULATOR receiver
E4625_00070	COG2205	protein histidine kinase activity
E4625_00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4625_00100	COG4191	Histidine kinase
E4625_00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4625_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_00115	COG1309	transcriptional regulator
E4625_00145	COG0469	pyruvate kinase activity
E4625_00150	COG2271	Major facilitator Superfamily
E4625_00155	COG1840	ABC-type Fe3 transport system, periplasmic component
E4625_00175	COG0561	phosphatase activity
E4625_00180	COG2267	carboxylic ester hydrolase activity
E4625_00190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4625_00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4625_00200	COG1758	RNA polymerase activity
E4625_00210	COG0859	PFAM glycosyl transferase family 9
E4625_00215	COG3642	lipopolysaccharide core region biosynthetic process
E4625_00255	COG0589	response to stress
E4625_00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4625_00265	COG3706	GGDEF domain
E4625_00270	COG1528	Iron-storage protein
E4625_00275	COG2081	HI0933 family
E4625_00280	COG2223	nitrite transmembrane transporter activity
E4625_00300	COG3188	usher protein
E4625_00320	COG2205	protein histidine kinase activity
E4625_00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_00330	COG3275	phosphorelay sensor kinase activity
E4625_00335	COG3279	Response regulator of the LytR AlgR family
E4625_00340	COG2223	nitrite transmembrane transporter activity
E4625_00345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4625_00350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4625_00365	COG0583	DNA-binding transcription factor activity
E4625_00370	COG4206	TonB-dependent receptor
E4625_00375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4625_00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4625_00415	COG2166	iron-sulfur cluster assembly
E4625_00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4625_00425	COG0210	DNA helicase
E4625_00435	COG3245	cytochrome
E4625_00440	COG1063	alcohol dehydrogenase
E4625_00445	COG0156	8-amino-7-oxononanoate synthase activity
E4625_00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4625_00470	COG3306	glycosyltransferase involved in LPS biosynthesis
E4625_00490	COG1561	YicC-like family, N-terminal region
E4625_00495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4625_00500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4625_00510	COG0789	Transcriptional regulator
E4625_00515	COG5001	Diguanylate cyclase
E4625_00515	COG2203	Gaf domain
E4625_00515	COG3706	GGDEF domain
E4625_00515	COG4251	negative regulation of phosphorylation
E4625_00520	COG3084	Protein conserved in bacteria
E4625_00530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4625_00535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4625_00545	COG1335	isochorismatase
E4625_00555	COG1683	Conserved Protein
E4625_00560	COG0204	Acyl-transferase
E4625_00565	COG0204	Acyl-transferase
E4625_00570	COG0606	chelatase, subunit chli
E4625_00585	COG3978	acetolactate synthase activity
E4625_00590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4625_00595	COG0129	dihydroxy-acid dehydratase activity
E4625_00615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4625_00620	COG0254	rRNA binding
E4625_00625	COG0702	epimerase
E4625_00630	COG0281	malic enzyme
E4625_00640	COG2205	protein histidine kinase activity
E4625_00645	COG0745	RESPONSE REGULATOR receiver
E4625_00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4625_00685	COG4310	Domain of unknown function (DUF2172)
E4625_00705	COG2089	acid synthase
E4625_00715	COG1083	cytidylyl-transferase
E4625_00730	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_00735	COG0318	PFAM AMP-dependent synthetase and ligase
E4625_00750	COG1215	transferase activity, transferring glycosyl groups
E4625_00760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4625_00805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4625_00810	COG1086	Polysaccharide biosynthesis protein
E4625_00815	COG0366	Alpha amylase catalytic
E4625_00830	COG0443	Heat shock 70 kDa protein
E4625_00835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4625_00840	COG3045	CreA protein
E4625_00855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4625_00860	COG0174	glutamine synthetase
E4625_00880	COG3842	ATPase activity
E4625_00885	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4625_00890	COG1177	transmembrane transport
E4625_00895	COG2258	MOSC domain
E4625_00915	COG2050	protein possibly involved in aromatic compounds catabolism
E4625_00920	COG0514	ATP-dependent DNA helicase (RecQ)
E4625_00930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4625_00940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4625_00945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4625_00955	COG2239	Acts as a magnesium transporter
E4625_00960	COG1648	precorrin-2 dehydrogenase activity
E4625_00960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4625_00965	COG2116	formate transmembrane transporter activity
E4625_00970	COG2146	nitrite reductase [NAD(P)H] activity
E4625_00975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4625_00990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4625_00995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4625_01015	COG1595	DNA-templated transcription, initiation
E4625_01020	COG3806	Anti-sigma factor
E4625_01025	COG1968	undecaprenyl-diphosphatase activity
E4625_01030	COG0667	Aldo Keto reductase
E4625_01035	COG2017	converts alpha-aldose to the beta-anomer
E4625_01040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4625_01050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4625_01055	COG1609	Transcriptional regulator
E4625_01060	COG3250	beta-galactosidase activity
E4625_01110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4625_01115	COG1288	antiporter activity
E4625_01120	COG1438	arginine binding
E4625_01125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4625_01130	COG0540	Belongs to the ATCase OTCase family
E4625_01150	COG0688	phosphatidylethanolamine metabolic process
E4625_01165	COG3040	lipid binding
E4625_01170	COG2207	Transcriptional regulator
E4625_01175	COG1979	alcohol dehydrogenase
E4625_01180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4625_01185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4625_01195	COG3681	Belongs to the UPF0597 family
E4625_01205	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4625_01210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4625_01215	COG0564	pseudouridine synthase activity
E4625_01230	COG0542	response to heat
E4625_01235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4625_01245	COG2502	aspartate--ammonia ligase
E4625_01250	COG1522	sequence-specific DNA binding
E4625_01260	COG5413	integral membrane protein
E4625_01285	COG2205	protein histidine kinase activity
E4625_01295	COG2204	response regulator
E4625_01315	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4625_01330	COG0745	RESPONSE REGULATOR receiver
E4625_01335	COG2205	protein histidine kinase activity
E4625_01345	COG0243	molybdopterin cofactor binding
E4625_01350	COG3005	denitrification pathway
E4625_01355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4625_01375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4625_01380	COG0569	domain protein
E4625_01385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4625_01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4625_01420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4625_01425	COG0250	Participates in transcription elongation, termination and antitermination
E4625_01430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4625_01435	COG0081	regulation of translation
E4625_01440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4625_01445	COG0222	ribosome binding
E4625_01450	COG0085	RNA polymerase activity
E4625_01455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4625_01460	COG2964	Protein conserved in bacteria
E4625_01465	COG0251	oxidation-reduction process
E4625_01475	COG2923	Belongs to the DsrF TusC family
E4625_01480	COG2168	tRNA wobble position uridine thiolation
E4625_01485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4625_01490	COG0049	tRNA binding
E4625_01495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4625_01500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4625_01505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4625_01545	COG2252	PERMEase
E4625_01550	COG2376	Dihydroxyacetone kinase
E4625_01555	COG1461	Dihydroxyacetone kinase
E4625_01570	COG3284	Transcriptional regulator
E4625_01580	COG2957	Belongs to the agmatine deiminase family
E4625_01590	COG0628	permease
E4625_01595	COG0494	nUDIX hydrolase
E4625_01620	COG0753	catalase activity
E4625_01625	COG1247	-acetyltransferase
E4625_01645	COG3706	GGDEF domain
E4625_01655	COG3842	ATPase activity
E4625_01665	COG1175	transmembrane transport
E4625_01695	COG0583	DNA-binding transcription factor activity
E4625_01705	COG1741	Belongs to the pirin family
E4625_01710	COG2259	Doxx family
E4625_01715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4625_01720	COG1074	ATP-dependent DNA helicase activity
E4625_01725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4625_01745	COG0346	lactoylglutathione lyase activity
E4625_01755	COG3706	GGDEF domain
E4625_01780	COG0745	RESPONSE REGULATOR receiver
E4625_01790	COG3706	GGDEF domain
E4625_01795	COG4771	TonB-dependent receptor
E4625_01800	COG1278	Cold shock
E4625_01825	COG0629	single-stranded DNA binding
E4625_01830	COG2197	response regulator
E4625_01835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4625_01840	COG3706	GGDEF domain
E4625_01845	COG3047	cAMP biosynthetic process
E4625_01850	COG0840	transmembrane signaling receptor activity
E4625_01875	COG3135	benzoate transporter
E4625_01880	COG1396	sequence-specific DNA binding
E4625_01915	COG2926	Belongs to the UPF0265 family
E4625_01925	COG3028	Belongs to the UPF0307 family
E4625_01930	COG0312	modulator of DNA gyrase
E4625_01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4625_01940	COG5007	Belongs to the BolA IbaG family
E4625_01950	COG2854	intermembrane phospholipid transfer
E4625_01955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4625_01960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4625_01965	COG1127	ABC transporter
E4625_01970	COG0517	IMP dehydrogenase activity
E4625_01970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4625_01975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4625_01980	COG3117	lipopolysaccharide transmembrane transporter activity
E4625_01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4625_01990	COG1137	ATPase activity
E4625_01995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4625_02005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_02010	COG1660	Displays ATPase and GTPase activities
E4625_02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_02020	COG3711	transcriptional antiterminator
E4625_02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_02035	COG3964	amidohydrolase
E4625_02065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4625_02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4625_02080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4625_02085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4625_02090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4625_02095	COG0723	plastoquinol--plastocyanin reductase activity
E4625_02100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4625_02105	COG2857	Cytochrome c1
E4625_02110	COG0625	glutathione transferase activity
E4625_02115	COG2969	positive regulation of protein catabolic process
E4625_02120	COG2823	Periplasmic or secreted lipoprotein
E4625_02125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4625_02130	COG0792	nuclease activity
E4625_02135	COG3107	peptidoglycan biosynthetic process
E4625_02140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4625_02150	COG2001	Belongs to the MraZ family
E4625_02155	COG0275	rRNA processing
E4625_02160	COG3116	cell division
E4625_02165	COG0768	penicillin binding
E4625_02170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4625_02175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4625_02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4625_02185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4625_02190	COG0772	Belongs to the SEDS family
E4625_02195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4625_02200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4625_02205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4625_02210	COG0849	cell division
E4625_02215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4625_02220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4625_02230	COG0653	protein targeting
E4625_02245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4625_02250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4625_02265	COG1459	type II secretion system
E4625_02270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4625_02300	COG2186	Transcriptional regulator
E4625_02305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4625_02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4625_02315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4625_02320	COG3706	GGDEF domain
E4625_02330	COG0840	transmembrane signaling receptor activity
E4625_02335	COG0840	transmembrane signaling receptor activity
E4625_02340	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4625_02345	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4625_02350	COG2200	EAL domain
E4625_02360	COG1280	lysine exporter protein (LysE YggA)
E4625_02370	COG0523	cobalamin synthesis protein
E4625_02375	COG0477	Major facilitator Superfamily
E4625_02390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4625_02395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4625_02440	COG0784	Response regulator, receiver
E4625_02440	COG0835	chemotaxis
E4625_02450	COG1444	tRNA N-acetyltransferase activity
E4625_02475	COG1803	Methylglyoxal synthase
E4625_02490	COG0252	asparaginase activity
E4625_02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_02510	COG1263	PTS System
E4625_02515	COG0366	Alpha amylase catalytic
E4625_02520	COG0110	maltose O-acetyltransferase activity
E4625_02525	COG1522	sequence-specific DNA binding
E4625_02530	COG5006	permease, DMT superfamily
E4625_02540	COG1012	belongs to the aldehyde dehydrogenase family
E4625_02545	COG1177	transmembrane transport
E4625_02550	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4625_02555	COG3842	ATPase activity
E4625_02560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4625_02565	COG0583	DNA-binding transcription factor activity
E4625_02570	COG1757	Na H antiporter
E4625_02610	COG0297	glycogen (starch) synthase activity
E4625_02615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4625_02620	COG2813	Specifically methylates the guanine in position
E4625_02625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4625_02630	COG5001	Diguanylate cyclase
E4625_02630	COG4251	negative regulation of phosphorylation
E4625_02630	COG3706	GGDEF domain
E4625_02630	COG2203	Gaf domain
E4625_02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4625_02650	COG2995	paraquat-inducible protein a
E4625_02655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4625_02655	COG3008	intermembrane lipid transfer
E4625_02660	COG3009	Protein conserved in bacteria
E4625_02665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4625_02665	COG2885	chlorophyll binding
E4625_02675	COG3240	lipase activity
E4625_02680	COG3111	PFAM Bacterial OB fold (BOF) protein
E4625_02690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4625_02695	COG1194	a g-specific adenine glycosylase
E4625_02705	COG3409	Peptidoglycan-binding domain 1 protein
E4625_02705	COG3267	Type II secretory pathway component ExeA
E4625_02710	COG0617	tRNA 3'-terminal CCA addition
E4625_02725	COG1346	cytolysis
E4625_02730	COG1380	Effector of murein hydrolase LrgA
E4625_02735	COG0583	DNA-binding transcription factor activity
E4625_02765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4625_02770	COG0306	phosphate transporter
E4625_02775	COG1392	Phosphate transport regulator
E4625_02790	COG1560	Kdo2-lipid A biosynthetic process
E4625_02795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4625_02795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4625_02800	COG1538	Outer membrane efflux protein
E4625_02805	COG0494	nUDIX hydrolase
E4625_02810	COG3151	Protein conserved in bacteria
E4625_02820	COG3150	esterase
E4625_02825	COG1051	belongs to the nudix hydrolase family
E4625_02840	COG1566	PFAM secretion protein HlyD family protein
E4625_02845	COG1289	transmembrane transporter activity
E4625_02850	COG0187	DNA topoisomerase II activity
E4625_02860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4625_02895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4625_02915	COG0204	Acyl-transferase
E4625_02920	COG1842	Phage shock protein A
E4625_02935	COG2827	Endonuclease containing a URI domain
E4625_02945	COG2962	Rard protein
E4625_02950	COG1573	uracil-dna glycosylase
E4625_02955	COG0697	spore germination
E4625_02960	COG0583	DNA-binding transcription factor activity
E4625_02965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4625_02970	COG1121	(ABC) transporter
E4625_02975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4625_02995	COG0739	heme binding
E4625_03000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4625_03005	COG3068	Protein conserved in bacteria
E4625_03025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4625_03030	COG1546	Belongs to the CinA family
E4625_03035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4625_03045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4625_03050	COG0527	aspartate kinase activity
E4625_03055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4625_03090	COG1686	Belongs to the peptidase S11 family
E4625_03095	COG0586	Pfam SNARE associated Golgi protein
E4625_03100	COG1253	flavin adenine dinucleotide binding
E4625_03105	COG0525	valine-tRNA ligase activity
E4625_03110	COG2927	DNA polymerase III (CHI subunit)
E4625_03115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4625_03120	COG0795	lipopolysaccharide-transporting ATPase activity
E4625_03125	COG0795	lipopolysaccharide-transporting ATPase activity
E4625_03140	COG0004	ammonium transporteR
E4625_03145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4625_03160	COG0084	hydrolase, TatD family'
E4625_03165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4625_03175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4625_03180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4625_03185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4625_03190	COG0813	purine-nucleoside phosphorylase activity
E4625_03195	COG3447	MASE1 domain protein
E4625_03195	COG5001	Diguanylate cyclase
E4625_03195	COG5002	protein histidine kinase activity
E4625_03205	COG0560	Phosphoserine phosphatase
E4625_03230	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4625_03240	COG0776	regulation of translation
E4625_03255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4625_03260	COG0735	belongs to the Fur family
E4625_03285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4625_03290	COG0513	Belongs to the DEAD box helicase family
E4625_03295	COG3022	response to hydroperoxide
E4625_03310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4625_03315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4625_03320	COG0762	integral membrane protein
E4625_03325	COG1872	DUF167
E4625_03340	COG4166	transmembrane transport
E4625_03360	COG1024	Enoyl-CoA hydratase
E4625_03375	COG4221	oxidoreductase activity
E4625_03380	COG0442	prolyl-tRNA aminoacylation
E4625_03385	COG0840	transmembrane signaling receptor activity
E4625_03390	COG0632	four-way junction helicase activity
E4625_03395	COG2255	four-way junction helicase activity
E4625_03400	COG1271	oxidase subunit
E4625_03405	COG1294	oxidase, subunit
E4625_03410	COG4890	Cyd operon protein YbgT
E4625_03415	COG3790	cyd operon protein YbgE
E4625_03420	COG0824	Thioesterase
E4625_03425	COG0811	peptide transport
E4625_03440	COG0823	Involved in the tonB-independent uptake of proteins
E4625_03445	COG2885	chlorophyll binding
E4625_03450	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4625_03530	COG0840	transmembrane signaling receptor activity
E4625_03535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4625_03540	COG0676	glucose-6-phosphate 1-epimerase activity
E4625_03545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4625_03550	COG1640	4-alpha-glucanotransferase
E4625_03555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4625_03575	COG1051	belongs to the nudix hydrolase family
E4625_03580	COG2130	NADP-dependent
E4625_03585	COG1764	response to oxidative stress
E4625_03590	COG1846	Transcriptional regulator
E4625_03605	COG1522	sequence-specific DNA binding
E4625_03625	COG0561	phosphatase activity
E4625_03640	COG0733	neurotransmitter:sodium symporter activity
E4625_03650	COG0733	neurotransmitter:sodium symporter activity
E4625_03675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4625_03685	COG1794	racemase activity, acting on amino acids and derivatives
E4625_03700	COG2731	YhcH YjgK YiaL family protein
E4625_03710	COG0668	transmembrane transport
E4625_03720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4625_03730	COG3436	PFAM IS66 Orf2 family protein
E4625_03735	COG4372	Transposase
E4625_03745	COG0789	Transcriptional regulator
E4625_03785	COG0583	DNA-binding transcription factor activity
E4625_03790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4625_03800	COG0488	(ABC) transporter
E4625_03805	COG0517	IMP dehydrogenase activity
E4625_03805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4625_03810	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4625_03815	COG0330	HflC and HflK could
E4625_03820	COG1648	precorrin-2 dehydrogenase activity
E4625_03820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4625_03825	COG0175	sulfate reduction
E4625_03830	COG2895	sulfate adenylyltransferase (ATP) activity
E4625_03835	COG0471	metal ion transport
E4625_03835	COG3273	potassium ion transport
E4625_03840	COG0529	Catalyzes the synthesis of activated sulfate
E4625_03870	COG0840	transmembrane signaling receptor activity
E4625_03905	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4625_03925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4625_03930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4625_03935	COG0163	prenyltransferase activity
E4625_03950	COG1131	(ABC) transporter
E4625_03955	COG0842	Transport permease protein
E4625_03960	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4625_03965	COG1924	4 iron, 4 sulfur cluster binding
E4625_03985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4625_03990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4625_03995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4625_04005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4625_04010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4625_04015	COG1489	DNA binding
E4625_04025	COG1643	Atp-dependent helicase
E4625_04030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4625_04035	COG0346	lactoylglutathione lyase activity
E4625_04045	COG2076	Multidrug Resistance protein
E4625_04055	COG0784	Response regulator, receiver
E4625_04055	COG3437	response regulator, receiver
E4625_04065	COG0671	phosphoesterase, PA-phosphatase related
E4625_04085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4625_04090	COG0038	chloride channel
E4625_04100	COG0316	Belongs to the HesB IscA family
E4625_04125	COG1280	lysine exporter protein (LysE YggA)
E4625_04130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4625_04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_04175	COG0745	RESPONSE REGULATOR receiver
E4625_04180	COG3104	oligopeptide transport
E4625_04185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4625_04190	COG1555	photosystem II stabilization
E4625_04200	COG2350	Protein conserved in bacteria
E4625_04205	COG2917	probably involved in intracellular septation
E4625_04210	COG0076	glutamate decarboxylase activity
E4625_04215	COG1272	protein, Hemolysin III
E4625_04220	COG0569	domain protein
E4625_04220	COG2985	domain, Protein
E4625_04320	COG0784	Response regulator, receiver
E4625_04320	COG0835	chemotaxis
E4625_04325	COG2755	lipolytic protein G-D-S-L family
E4625_04330	COG4181	ATPase activity
E4625_04335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4625_04340	COG1090	epimerase
E4625_04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4625_04355	COG2234	aminopeptidase activity
E4625_04355	COG4935	Belongs to the peptidase S8 family
E4625_04360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4625_04365	COG3171	Protein conserved in bacteria
E4625_04370	COG2066	Belongs to the glutaminase family
E4625_04375	COG2897	thiosulfate sulfurtransferase activity
E4625_04390	COG1132	(ABC) transporter
E4625_04415	COG3291	Pkd domain containing protein
E4625_04415	COG4412	M6 family metalloprotease domain protein
E4625_04425	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4625_04430	COG5001	Diguanylate cyclase
E4625_04430	COG3300	MHYT domain
E4625_04440	COG2207	Transcriptional regulator
E4625_04445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4625_04450	COG3059	membrane
E4625_04465	COG4628	conserved protein (DUF2132)
E4625_04470	COG0688	phosphatidylethanolamine metabolic process
E4625_04475	COG1162	GTPase activity
E4625_04480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4625_04520	COG1278	Cold shock
E4625_04530	COG0840	transmembrane signaling receptor activity
E4625_04535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4625_04585	COG0848	biopolymer transport protein
E4625_04590	COG0811	peptide transport
E4625_04595	COG0811	peptide transport
E4625_04610	COG4174	ABC transporter (Permease)
E4625_04615	COG4239	(ABC) transporter, permease
E4625_04625	COG0444	Belongs to the ABC transporter superfamily
E4625_04630	COG4608	Belongs to the ABC transporter superfamily
E4625_04640	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4625_04655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4625_04675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4625_04705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_04710	COG2313	pseudouridylate synthase activity
E4625_04720	COG1858	cytochrome C peroxidase
E4625_04755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4625_04760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4625_04785	COG2986	histidine ammonia-lyase
E4625_04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4625_04820	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_04825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4625_04835	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4625_04845	COG2966	Psort location CytoplasmicMembrane, score
E4625_04850	COG3610	response to peptide
E4625_04860	COG4175	Glycine betaine
E4625_04865	COG4176	ABC-type proline glycine betaine transport system permease component
E4625_04870	COG2113	Glycine betaine
E4625_04875	COG0175	sulfate reduction
E4625_04880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4625_04885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4625_04890	COG0384	phenazine biosynthesis protein PhzF
E4625_04895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4625_04910	COG0786	glutamate:sodium symporter activity
E4625_04915	COG0252	asparaginase activity
E4625_04920	COG3139	Protein of unknown function (DUF1315)
E4625_04940	COG0616	signal peptide processing
E4625_04945	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4625_04945	COG1902	pentaerythritol trinitrate reductase activity
E4625_04950	COG0778	Nitroreductase
E4625_04965	COG2264	protein methyltransferase activity
E4625_04970	COG0604	alcohol dehydrogenase
E4625_04975	COG0583	DNA-binding transcription factor activity
E4625_04980	COG2190	(PTS) system
E4625_04980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_04980	COG1263	PTS System
E4625_04985	COG4145	pantothenate transmembrane transporter activity
E4625_04995	COG0439	Biotin carboxylase
E4625_05000	COG0511	ligase activity, forming carbon-carbon bonds
E4625_05005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4625_05010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4625_05020	COG3300	MHYT domain
E4625_05020	COG5001	Diguanylate cyclase
E4625_05040	COG3381	protein complex oligomerization
E4625_05050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4625_05060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4625_05065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4625_05065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4625_05085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4625_05090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4625_05095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4625_05100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4625_05125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4625_05130	COG0142	geranyltranstransferase activity
E4625_05135	COG1722	exodeoxyribonuclease VII activity
E4625_05140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4625_05145	COG1360	Flagellar Motor Protein
E4625_05150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4625_05160	COG1534	Rna-binding protein
E4625_05165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4625_05170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4625_05175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4625_05180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4625_05185	COG0149	triose-phosphate isomerase activity
E4625_05190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4625_05205	COG0779	Required for maturation of 30S ribosomal subunits
E4625_05210	COG0195	Participates in both transcription termination and antitermination
E4625_05215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4625_05220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4625_05225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4625_05230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4625_05235	COG1185	polyribonucleotide nucleotidyltransferase activity
E4625_05240	COG2211	Major facilitator Superfamily
E4625_05250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4625_05260	COG0114	fumarate hydratase activity
E4625_05270	COG1966	Carbon starvation protein
E4625_05275	COG3279	Response regulator of the LytR AlgR family
E4625_05280	COG3275	phosphorelay sensor kinase activity
E4625_05345	COG0312	modulator of DNA gyrase
E4625_05350	COG0312	modulator of DNA gyrase
E4625_05355	COG0716	FMN binding
E4625_05360	COG4974	Belongs to the 'phage' integrase family
E4625_05365	COG3706	GGDEF domain
E4625_05370	COG1970	mechanosensitive ion channel activity
E4625_05375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4625_05385	COG0789	Transcriptional regulator
E4625_05400	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4625_05405	COG3545	Serine hydrolase
E4625_05415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4625_05425	COG0321	lipoyl(octanoyl) transferase activity
E4625_05430	COG2921	Belongs to the UPF0250 family
E4625_05435	COG1686	Belongs to the peptidase S11 family
E4625_05440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4625_05445	COG2951	lytic endotransglycosylase activity
E4625_05450	COG0772	Belongs to the SEDS family
E4625_05455	COG0772	Belongs to the SEDS family
E4625_05460	COG0768	penicillin binding
E4625_05465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4625_05470	COG0799	negative regulation of ribosome biogenesis
E4625_05475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4625_05495	COG0495	leucyl-tRNA aminoacylation
E4625_05500	COG2888	peptidyl-tyrosine sulfation
E4625_05505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4625_05510	COG4535	Mg2 and Co2 transporter CorC
E4625_05515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4625_05520	COG1702	phosphate starvation-inducible protein PhoH
E4625_05525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4625_05530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4625_05535	COG1335	isochorismatase
E4625_05545	COG3706	GGDEF domain
E4625_05560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4625_05570	COG3706	GGDEF domain
E4625_05580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4625_05590	COG3647	Membrane
E4625_05595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4625_05605	COG0516	GMP reductase activity
E4625_05625	COG0642	Histidine kinase
E4625_05630	COG0745	RESPONSE REGULATOR receiver
E4625_05660	COG4106	trans-aconitate 2-methyltransferase activity
E4625_05665	COG3214	Protein conserved in bacteria
E4625_05690	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4625_05695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4625_05700	COG1053	succinate dehydrogenase
E4625_05710	COG0584	glycerophosphoryl diester phosphodiesterase
E4625_05715	COG3264	Mechanosensitive ion channel
E4625_05715	COG1511	domain protein
E4625_05725	COG0739	heme binding
E4625_05740	COG0583	DNA-binding transcription factor activity
E4625_05760	COG0583	DNA-binding transcription factor activity
E4625_05765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4625_05795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4625_05800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4625_05810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4625_05825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4625_05835	COG0180	Tryptophanyl-tRNA synthetase
E4625_05850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4625_05860	COG1012	belongs to the aldehyde dehydrogenase family
E4625_05870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4625_05880	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4625_05880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_05880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4625_05880	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4625_05890	COG0366	Alpha amylase catalytic
E4625_05910	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4625_05920	COG0490	domain, Protein
E4625_05920	COG0471	metal ion transport
E4625_05965	COG0012	GTP binding
E4625_05970	COG0193	aminoacyl-tRNA hydrolase activity
E4625_05975	COG0737	Belongs to the 5'-nucleotidase family
E4625_05980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4625_05990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4625_05995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4625_06000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4625_06005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4625_06010	COG2890	protein-(glutamine-N5) methyltransferase activity
E4625_06020	COG2912	Transglutaminase-like superfamily
E4625_06025	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4625_06030	COG1301	dicarboxylic acid transport
E4625_06040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4625_06055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4625_06060	COG1115	amino acid carrier protein
E4625_06075	COG0714	Associated with various cellular activities
E4625_06085	COG3104	oligopeptide transport
E4625_06090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4625_06095	COG1678	Uncharacterized ACR, COG1678
E4625_06105	COG0189	ligase activity
E4625_06110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4625_06120	COG3091	SprT-like family
E4625_06130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4625_06155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4625_06160	COG0739	heme binding
E4625_06165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4625_06170	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4625_06170	COG3408	Glycogen debranching enzyme
E4625_06180	COG1881	PFAM PEBP family protein
E4625_06190	COG0583	DNA-binding transcription factor activity
E4625_06200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4625_06210	COG0583	DNA-binding transcription factor activity
E4625_06215	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_06220	COG0616	signal peptide processing
E4625_06225	COG3724	N-succinylarginine dihydrolase activity
E4625_06230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4625_06245	COG0840	transmembrane signaling receptor activity
E4625_06255	COG2971	BadF BadG BcrA BcrD
E4625_06265	COG4608	Belongs to the ABC transporter superfamily
E4625_06270	COG0444	Belongs to the ABC transporter superfamily
E4625_06275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4625_06280	COG0601	transmembrane transport
E4625_06285	COG4166	transmembrane transport
E4625_06320	COG3220	belongs to the UPF0276 family
E4625_06350	COG1289	transmembrane transporter activity
E4625_06360	COG0746	molybdenum cofactor guanylyltransferase activity
E4625_06370	COG4662	Binding-protein-dependent transport system inner membrane component
E4625_06380	COG2204	response regulator
E4625_06385	COG3852	Histidine kinase
E4625_06390	COG1910	domain protein
E4625_06395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4625_06435	COG3383	formate dehydrogenase (NAD+) activity
E4625_06435	COG3383	formate dehydrogenase (NAD+) activity
E4625_06440	COG0437	4 iron, 4 sulfur cluster binding
E4625_06455	COG0281	malic enzyme
E4625_06475	COG2706	6-phosphogluconolactonase activity
E4625_06485	COG1196	nuclear chromosome segregation
E4625_06485	COG3264	Mechanosensitive ion channel
E4625_06490	COG0469	pyruvate kinase activity
E4625_06505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4625_06505	COG4651	solute:proton antiporter activity
E4625_06515	COG2974	May be involved in recombination
E4625_06525	COG0420	3'-5' exonuclease activity
E4625_06535	COG3038	cytochrome b561
E4625_06545	COG0745	RESPONSE REGULATOR receiver
E4625_06545	COG3706	GGDEF domain
E4625_06550	COG2190	(PTS) system
E4625_06560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_06565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4625_06570	COG0542	response to heat
E4625_06585	COG2770	Histidine kinase
E4625_06585	COG3437	response regulator, receiver
E4625_06590	COG1720	tRNA m6t6A37 methyltransferase activity
E4625_06610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4625_06615	COG4988	ABC transporter
E4625_06630	COG0745	RESPONSE REGULATOR receiver
E4625_06640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4625_06655	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4625_06660	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4625_06675	COG0083	homoserine kinase activity
E4625_06680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4625_06685	COG4319	ketosteroid isomerase
E4625_06700	COG0488	(ABC) transporter
E4625_06715	COG0813	purine-nucleoside phosphorylase activity
E4625_06730	COG2205	protein histidine kinase activity
E4625_06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_06735	COG3384	dioxygenase
E4625_06745	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4625_06755	COG0531	amino acid
E4625_06760	COG0531	amino acid
E4625_06775	COG1917	Cupin 2, conserved barrel domain protein
E4625_06775	COG1396	sequence-specific DNA binding
E4625_06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4625_06795	COG3152	Membrane
E4625_06815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4625_06820	COG2375	cellular response to nickel ion
E4625_06825	COG1538	Outer membrane efflux protein
E4625_06830	COG1136	(ABC) transporter
E4625_06830	COG0577	efflux transmembrane transporter activity
E4625_06835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_06845	COG1227	inorganic diphosphatase activity
E4625_06850	COG0497	DNA recombination
E4625_06855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4625_06860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4625_06865	COG0443	Heat shock 70 kDa protein
E4625_06870	COG0484	heat shock protein binding
E4625_06900	COG1285	pathogenesis
E4625_06915	COG0640	Transcriptional regulator
E4625_06945	COG0095	Lipoate-protein ligase
E4625_06965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4625_06970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_06990	COG0708	Exodeoxyribonuclease III
E4625_07050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4625_07055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4625_07060	COG1845	cytochrome c oxidase, subunit III
E4625_07065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4625_07070	COG0109	protoheme IX farnesyltransferase activity
E4625_07075	COG2814	Major facilitator Superfamily
E4625_07085	COG2198	Histidine kinase
E4625_07085	COG2205	protein histidine kinase activity
E4625_07085	COG0784	Response regulator, receiver
E4625_07090	COG1879	ABC-type sugar transport system periplasmic component
E4625_07100	COG0745	RESPONSE REGULATOR receiver
E4625_07105	COG3005	denitrification pathway
E4625_07115	COG3381	protein complex oligomerization
E4625_07155	COG2003	Belongs to the UPF0758 family
E4625_07195	COG0583	DNA-binding transcription factor activity
E4625_07210	COG0549	Belongs to the carbamate kinase family
E4625_07215	COG1304	FMN binding
E4625_07220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4625_07225	COG1335	isochorismatase
E4625_07240	COG3311	Transcriptional regulator
E4625_07265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4625_07295	COG0549	Belongs to the carbamate kinase family
E4625_07305	COG1304	FMN binding
E4625_07310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4625_07320	COG0666	response to abiotic stimulus
E4625_07325	COG0583	DNA-binding transcription factor activity
E4625_07365	COG2351	hydroxyisourate hydrolase activity
E4625_07390	COG0019	diaminopimelate decarboxylase activity
E4625_07395	COG4264	IucA IucC family
E4625_07420	COG4772	TonB-dependent receptor
E4625_07425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4625_07430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4625_07435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4625_07440	COG1120	ATPase activity
E4625_07485	COG4792	protein secretion
E4625_07490	COG4791	protein targeting
E4625_07495	COG4794	Type iii secretion
E4625_07500	COG4790	Type iii secretion
E4625_07505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4625_07575	COG0457	Tetratricopeptide repeat
E4625_07665	COG1317	bacterial-type flagellum organization
E4625_07695	COG3436	PFAM IS66 Orf2 family protein
E4625_07705	COG0159	tryptophan synthase activity
E4625_07710	COG0133	tryptophan synthase activity
E4625_07715	COG0135	phosphoribosylanthranilate isomerase activity
E4625_07715	COG0134	indole-3-glycerol-phosphate synthase activity
E4625_07720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4625_07725	COG0512	Glutamine amidotransferase of anthranilate synthase
E4625_07725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4625_07730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4625_07740	COG0009	L-threonylcarbamoyladenylate synthase
E4625_07750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4625_07760	COG1946	Acyl-CoA thioesterase
E4625_07775	COG1309	transcriptional regulator
E4625_07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_07785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4625_07790	COG1538	Outer membrane efflux protein
E4625_07800	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4625_07830	COG3754	Rhamnan synthesis protein F
E4625_07835	COG1215	transferase activity, transferring glycosyl groups
E4625_07850	COG2895	sulfate adenylyltransferase (ATP) activity
E4625_07855	COG0471	metal ion transport
E4625_07855	COG3273	potassium ion transport
E4625_07860	COG0529	Catalyzes the synthesis of activated sulfate
E4625_07875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4625_07945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4625_07970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4625_07980	COG3132	Protein of unknown function, DUF480
E4625_08020	COG1278	Cold shock
E4625_08045	COG4166	transmembrane transport
E4625_08050	COG0697	spore germination
E4625_08055	COG1349	DNA-binding transcription factor activity
E4625_08065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4625_08070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4625_08085	COG1187	pseudouridine synthase activity
E4625_08100	COG0622	Phosphoesterase
E4625_08115	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4625_08120	COG0784	Response regulator, receiver
E4625_08120	COG0835	chemotaxis
E4625_08125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4625_08130	COG1815	bacterial-type flagellum-dependent cell motility
E4625_08135	COG1558	bacterial-type flagellum-dependent cell motility
E4625_08150	COG4787	bacterial-type flagellum-dependent cell motility
E4625_08155	COG4786	Flagellar basal body rod
E4625_08160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4625_08165	COG1706	bacterial-type flagellum-dependent cell motility
E4625_08170	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4625_08170	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4625_08185	COG2239	Acts as a magnesium transporter
E4625_08190	COG0248	Ppx GppA phosphatase
E4625_08195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4625_08200	COG2716	regulation of RNA biosynthetic process
E4625_08210	COG2204	response regulator
E4625_08215	COG3852	Histidine kinase
E4625_08220	COG2204	response regulator
E4625_08225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4625_08230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4625_08235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4625_08240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4625_08260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4625_08270	COG0590	tRNA wobble adenosine to inosine editing
E4625_08275	COG0573	inorganic phosphate transmembrane transporter activity
E4625_08280	COG0581	inorganic phosphate transmembrane transporter activity
E4625_08290	COG0704	Plays a role in the regulation of phosphate uptake
E4625_08295	COG1253	flavin adenine dinucleotide binding
E4625_08310	COG0531	amino acid
E4625_08325	COG1126	abc transporter atp-binding protein
E4625_08330	COG0765	amino acid transport
E4625_08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_08340	COG3706	GGDEF domain
E4625_08345	COG2271	Major facilitator Superfamily
E4625_08360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4625_08385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4625_08390	COG0477	Major facilitator Superfamily
E4625_08395	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4625_08405	COG1199	ATP-dependent helicase activity
E4625_08410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4625_08420	COG1448	Aminotransferase
E4625_08425	COG0433	COG0433 Predicted ATPase
E4625_08440	COG2333	competence protein COMEC
E4625_08440	COG0658	competence protein
E4625_08445	COG1132	(ABC) transporter
E4625_08450	COG1663	tetraacyldisaccharide 4'-kinase activity
E4625_08455	COG2835	tetraacyldisaccharide 4'-kinase activity
E4625_08460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4625_08465	COG2197	response regulator
E4625_08470	COG0322	excinuclease ABC activity
E4625_08495	COG0582	viral genome integration into host DNA
E4625_08575	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4625_08580	COG0437	4 iron, 4 sulfur cluster binding
E4625_08585	COG3301	Polysulphide reductase, NrfD
E4625_08590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4625_08600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4625_08610	COG1196	nuclear chromosome segregation
E4625_08620	COG2199	diguanylate cyclase activity
E4625_08620	COG2203	Gaf domain
E4625_08650	COG2119	membrane
E4625_08655	COG0023	Translation Initiation Factor
E4625_08680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4625_08695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_08695	COG2205	protein histidine kinase activity
E4625_08705	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4625_08715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4625_08720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4625_08725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4625_08730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4625_08735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4625_08740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4625_08750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4625_08755	COG0505	Belongs to the CarA family
E4625_08760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4625_08765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4625_08775	COG2131	deaminase
E4625_08795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4625_08800	COG0513	Belongs to the DEAD box helicase family
E4625_08810	COG4104	PAAR repeat-containing protein
E4625_08825	COG0789	Transcriptional regulator
E4625_08840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_08845	COG0765	amino acid transport
E4625_08855	COG0493	'glutamate synthase
E4625_08860	COG0067	glutamate synthase
E4625_08860	COG0069	glutamate synthase activity
E4625_08860	COG0070	glutamate synthase
E4625_08865	COG1242	4 iron, 4 sulfur cluster binding
E4625_08920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4625_08925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4625_08925	COG0574	Belongs to the PEP-utilizing enzyme family
E4625_08955	COG1464	Belongs to the NlpA lipoprotein family
E4625_08960	COG0671	phosphoesterase, PA-phosphatase related
E4625_08965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4625_08970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4625_08980	COG0101	tRNA pseudouridine synthase activity
E4625_08985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4625_08990	COG0285	dihydrofolate synthase activity
E4625_08995	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4625_09000	COG2920	part of a sulfur-relay system
E4625_09005	COG1289	transmembrane transporter activity
E4625_09010	COG0670	Belongs to the BI1 family
E4625_09030	COG2194	sulfuric ester hydrolase activity
E4625_09040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4625_09040	COG0392	lysyltransferase activity
E4625_09050	COG0840	transmembrane signaling receptor activity
E4625_09055	COG5001	Diguanylate cyclase
E4625_09060	COG0564	pseudouridine synthase activity
E4625_09075	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4625_09085	COG0625	glutathione transferase activity
E4625_09090	COG0625	glutathione transferase activity
E4625_09100	COG0367	asparagine synthase
E4625_09110	COG4651	solute:proton antiporter activity
E4625_09110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4625_09115	COG0647	UMP catabolic process
E4625_09120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4625_09125	COG1902	pentaerythritol trinitrate reductase activity
E4625_09130	COG1253	flavin adenine dinucleotide binding
E4625_09140	COG0247	lactate metabolic process
E4625_09140	COG0277	FAD linked oxidase domain protein
E4625_09150	COG2050	protein possibly involved in aromatic compounds catabolism
E4625_09160	COG2056	Na+-H+ antiporter family
E4625_09165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4625_09180	COG0346	lactoylglutathione lyase activity
E4625_09185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4625_09195	COG4659	FMN binding
E4625_09200	COG4658	electron transport chain
E4625_09210	COG2878	Part of a membrane complex involved in electron transport
E4625_09215	COG4657	Part of a membrane complex involved in electron transport
E4625_09220	COG0697	spore germination
E4625_09240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4625_09245	COG1288	antiporter activity
E4625_09250	COG3422	double-strand break repair
E4625_09255	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4625_09325	COG4974	Belongs to the 'phage' integrase family
E4625_09330	COG0436	Aminotransferase
E4625_09340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4625_09345	COG2027	D-alanyl-D-alanine carboxypeptidase
E4625_09350	COG1061	Type III restriction enzyme res subunit
E4625_09355	COG1566	PFAM secretion protein HlyD family protein
E4625_09365	COG1966	Carbon starvation protein
E4625_09370	COG3279	Response regulator of the LytR AlgR family
E4625_09375	COG3275	phosphorelay sensor kinase activity
E4625_09380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4625_09380	COG2199	diguanylate cyclase activity
E4625_09385	COG1012	belongs to the aldehyde dehydrogenase family
E4625_09385	COG1454	alcohol dehydrogenase
E4625_09395	COG2095	MarC family integral membrane protein
E4625_09405	COG0601	transmembrane transport
E4625_09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4625_09415	COG0444	Belongs to the ABC transporter superfamily
E4625_09430	COG0861	Integral membrane protein TerC family
E4625_09435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4625_09445	COG1301	dicarboxylic acid transport
E4625_09465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4625_09480	COG0537	adenosine 5'-monophosphoramidase activity
E4625_09515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4625_09520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4625_09530	COG2354	Protein conserved in bacteria
E4625_09545	COG2233	PERMEase
E4625_09555	COG1252	NADH dehydrogenase
E4625_09575	COG0393	Putative heavy-metal-binding
E4625_09585	COG1648	precorrin-2 dehydrogenase activity
E4625_09585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4625_09590	COG2221	Nitrite and sulphite reductase 4Fe-4S
E4625_09605	COG4667	esterase of the alpha-beta hydrolase superfamily
E4625_09610	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4625_09615	COG1368	sulfuric ester hydrolase activity
E4625_09625	COG0527	aspartate kinase activity
E4625_09630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4625_09630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4625_09635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4625_09805	COG0596	Alpha beta hydrolase
E4625_09810	COG0346	lactoylglutathione lyase activity
E4625_09820	COG0583	DNA-binding transcription factor activity
E4625_09825	COG1620	l-lactate permease
E4625_09830	COG0247	lactate metabolic process
E4625_09835	COG1139	Iron-sulfur cluster binding protein
E4625_09880	COG1136	(ABC) transporter
E4625_09890	COG2814	Major facilitator Superfamily
E4625_09910	COG0672	)-iron permease
E4625_09940	COG0659	secondary active sulfate transmembrane transporter activity
E4625_09965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4625_09970	COG0840	transmembrane signaling receptor activity
E4625_09980	COG2201	protein-glutamate methylesterase activity
E4625_09990	COG0835	chemotaxis
E4625_09995	COG3290	protein histidine kinase activity
E4625_09995	COG0840	transmembrane signaling receptor activity
E4625_10000	COG2198	Histidine kinase
E4625_10000	COG0643	Histidine kinase
E4625_10010	COG0745	RESPONSE REGULATOR receiver
E4625_10015	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4625_10020	COG0437	4 iron, 4 sulfur cluster binding
E4625_10025	COG5557	Pfam Polysulphide reductase, NrfD
E4625_10030	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4625_10035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4625_10040	COG1773	rubredoxin
E4625_10050	COG0601	transmembrane transport
E4625_10055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4625_10065	COG3842	ATPase activity
E4625_10070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4625_10075	COG0375	protein maturation
E4625_10080	COG0309	Hydrogenase expression formation protein (HypE)
E4625_10090	COG0298	carbon dioxide binding
E4625_10095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4625_10105	COG1921	L-seryl-tRNASec selenium transferase activity
E4625_10110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4625_10120	COG3260	NADH ubiquinone oxidoreductase 20
E4625_10125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_10130	COG3261	NADH dehydrogenase
E4625_10130	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4625_10135	COG0650	Formate hydrogenlyase subunit 4
E4625_10140	COG0651	ATP synthesis coupled electron transport
E4625_10145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_10150	COG3158	transport of potassium into the cell
E4625_10160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_10185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4625_10195	COG0326	Molecular chaperone. Has ATPase activity
E4625_10205	COG0563	adenylate kinase activity
E4625_10210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4625_10220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_10235	COG5001	Diguanylate cyclase
E4625_10235	COG3300	MHYT domain
E4625_10240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4625_10260	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4625_10265	COG3433	isochorismatase activity
E4625_10265	COG1535	isochorismatase
E4625_10270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4625_10275	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4625_10295	COG1051	belongs to the nudix hydrolase family
E4625_10300	COG4235	cytochrome complex assembly
E4625_10300	COG3088	subunit of a heme lyase
E4625_10305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4625_10310	COG1138	Cytochrome C-type biogenesis protein
E4625_10315	COG3301	Polysulphide reductase, NrfD
E4625_10320	COG0437	4 iron, 4 sulfur cluster binding
E4625_10325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4625_10340	COG0247	lactate metabolic process
E4625_10345	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4625_10350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4625_10355	COG3012	SEC-C Motif Domain Protein
E4625_10360	COG0840	transmembrane signaling receptor activity
E4625_10365	COG1846	Transcriptional regulator
E4625_10365	COG1940	carbohydrate kinase activity
E4625_10370	COG3290	protein histidine kinase activity
E4625_10375	COG4565	transcriptional regulatory protein
E4625_10395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4625_10400	COG2985	domain, Protein
E4625_10400	COG0569	domain protein
E4625_10415	COG0556	nucleotide-excision repair
E4625_10425	COG0586	Pfam SNARE associated Golgi protein
E4625_10430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4625_10435	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4625_10440	COG2186	Transcriptional regulator
E4625_10445	COG2719	SpoVR family
E4625_10455	COG2766	serine protein kinase
E4625_10460	COG0514	ATP-dependent DNA helicase (RecQ)
E4625_10465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4625_10470	COG0814	amino acid
E4625_10505	COG0058	SHG alpha-glucan phosphorylase activity
E4625_10510	COG0471	metal ion transport
E4625_10515	COG3118	belongs to the thioredoxin family
E4625_10525	COG1132	(ABC) transporter
E4625_10535	COG1132	(ABC) transporter
E4625_10550	COG2501	S4 domain
E4625_10560	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4625_10585	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4625_10590	COG2329	Antibiotic biosynthesis monooxygenase
E4625_10625	COG0456	acetyltransferase
E4625_10630	COG0513	Belongs to the DEAD box helicase family
E4625_10635	COG0386	Belongs to the glutathione peroxidase family
E4625_10650	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4625_10665	COG0730	response to heat
E4625_10670	COG0583	DNA-binding transcription factor activity
E4625_10685	COG3593	DNA synthesis involved in DNA repair
E4625_10740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4625_10745	COG1011	Hydrolase
E4625_10750	COG1473	amidohydrolase
E4625_10755	COG0205	6-phosphofructokinase activity
E4625_10765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4625_10770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4625_10780	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4625_10785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4625_10805	COG0242	peptide deformylase activity
E4625_10835	COG0384	phenazine biosynthesis protein PhzF
E4625_10855	COG2824	Alkylphosphonate utilization operon protein PhnA
E4625_10885	COG3706	GGDEF domain
E4625_10895	COG2840	Smr protein MutS2
E4625_10900	COG2890	protein-(glutamine-N5) methyltransferase activity
E4625_10905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4625_10915	COG0513	Belongs to the DEAD box helicase family
E4625_10920	COG5654	RES domain protein
E4625_10930	COG0814	amino acid
E4625_10935	COG1609	Transcriptional regulator
E4625_10940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_10940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_10945	COG1105	Belongs to the carbohydrate kinase PfkB family
E4625_10950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4625_10950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_10950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_10955	COG2140	Oxalate decarboxylase
E4625_10960	COG1609	Transcriptional regulator
E4625_10975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_10975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_10980	COG3715	PTS system
E4625_10985	COG3716	PTS system mannose fructose sorbose family IID component
E4625_10990	COG2942	2-epimerase
E4625_10995	COG3313	Fe-S protein
E4625_11000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4625_11005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4625_11010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4625_11015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4625_11025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4625_11045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4625_11050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4625_11055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4625_11060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4625_11065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4625_11070	COG0072	phenylalanine-tRNA ligase activity
E4625_11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4625_11075	COG0776	regulation of translation
E4625_11095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4625_11105	COG2199	diguanylate cyclase activity
E4625_11110	COG1609	Transcriptional regulator
E4625_11115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_11120	COG1879	ABC-type sugar transport system periplasmic component
E4625_11125	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4625_11130	COG1129	ABC transporter
E4625_11135	COG1869	D-ribose catabolic process
E4625_11155	COG0037	tRNA processing
E4625_11160	COG0589	response to stress
E4625_11165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4625_11190	COG2010	Cytochrome c
E4625_11205	COG3278	Belongs to the heme-copper respiratory oxidase family
E4625_11215	COG1956	GAF domain-containing protein
E4625_11220	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4625_11230	COG0308	aminopeptidase N
E4625_11240	COG2902	Dehydrogenase
E4625_11245	COG0167	dihydroorotate dehydrogenase activity
E4625_11255	COG0116	Belongs to the methyltransferase superfamily
E4625_11255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4625_11280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4625_11285	COG1067	ATP-dependent peptidase activity
E4625_11295	COG3141	response to X-ray
E4625_11305	COG4221	oxidoreductase activity
E4625_11350	COG0372	Belongs to the citrate synthase family
E4625_11355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4625_11365	COG2995	paraquat-inducible protein a
E4625_11370	COG3008	intermembrane lipid transfer
E4625_11375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4625_11375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4625_11390	COG0084	hydrolase, TatD family'
E4625_11395	COG0470	DNA polymerase III
E4625_11400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4625_11405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4625_11410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4625_11415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4625_11420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4625_11425	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_11435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4625_11440	COG0416	fatty acid biosynthetic process
E4625_11445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4625_11450	COG1399	metal-binding, possibly nucleic acid-binding protein
E4625_11465	COG2814	Major facilitator Superfamily
E4625_11470	COG0424	maF-like protein
E4625_11475	COG0546	phosphoglycolate phosphatase activity
E4625_11480	COG0564	pseudouridine synthase activity
E4625_11485	COG1530	ribonuclease E activity
E4625_11490	COG0306	phosphate transporter
E4625_11495	COG0717	Belongs to the dCTP deaminase family
E4625_11500	COG0572	uridine kinase
E4625_11505	COG0489	protein tyrosine kinase activity
E4625_11510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4625_11510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4625_11515	COG0625	glutathione transferase activity
E4625_11520	COG1254	Belongs to the acylphosphatase family
E4625_11525	COG0840	transmembrane signaling receptor activity
E4625_11530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4625_11545	COG0709	Synthesizes selenophosphate from selenide and ATP
E4625_11550	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4625_11555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4625_11560	COG3437	response regulator, receiver
E4625_11570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4625_11580	COG1643	Atp-dependent helicase
E4625_11735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4625_11740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4625_11885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4625_11910	COG0582	viral genome integration into host DNA
E4625_11915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4625_11925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4625_11930	COG2832	Protein of unknown function (DUF454)
E4625_11935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4625_11955	COG0318	PFAM AMP-dependent synthetase and ligase
E4625_11960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4625_11960	COG2226	methyltransferase
E4625_11960	COG0596	Alpha beta hydrolase
E4625_11970	COG1214	PFAM Peptidase M22, glycoprotease
E4625_11980	COG1199	ATP-dependent helicase activity
E4625_11990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4625_11995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4625_12000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4625_12005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4625_12005	COG0131	Imidazoleglycerol-phosphate dehydratase
E4625_12010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4625_12015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4625_12020	COG3437	response regulator, receiver
E4625_12030	COG2205	protein histidine kinase activity
E4625_12030	COG0784	Response regulator, receiver
E4625_12030	COG2198	Histidine kinase
E4625_12035	COG0107	imidazoleglycerol-phosphate synthase activity
E4625_12040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4625_12040	COG0140	phosphoribosyl-ATP diphosphatase activity
E4625_12050	COG0318	PFAM AMP-dependent synthetase and ligase
E4625_12055	COG1288	antiporter activity
E4625_12065	COG3134	Outer membrane lipoprotein
E4625_12075	COG2080	2 iron, 2 sulfur cluster binding
E4625_12080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4625_12085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4625_12090	COG2252	PERMEase
E4625_12095	COG0402	S-adenosylhomocysteine deaminase activity
E4625_12100	COG2233	PERMEase
E4625_12105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4625_12105	COG2080	2 iron, 2 sulfur cluster binding
E4625_12110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4625_12115	COG0402	S-adenosylhomocysteine deaminase activity
E4625_12120	COG0493	'glutamate synthase
E4625_12120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_12125	COG2068	MobA-Related Protein
E4625_12130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4625_12135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4625_12135	COG3608	succinylglutamate desuccinylase aspartoacylase
E4625_12140	COG0697	spore germination
E4625_12145	COG0549	Belongs to the carbamate kinase family
E4625_12155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4625_12160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4625_12165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4625_12180	COG4681	YaeQ
E4625_12190	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4625_12190	COG1024	Enoyl-CoA hydratase
E4625_12195	COG0183	Belongs to the thiolase family
E4625_12200	COG0714	Associated with various cellular activities
E4625_12230	COG1595	DNA-templated transcription, initiation
E4625_12245	COG2067	long-chain fatty acid transport protein
E4625_12250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4625_12455	COG3123	guanosine phosphorylase activity
E4625_12460	COG1760	l-serine dehydratase
E4625_12470	COG1760	l-serine dehydratase
E4625_12475	COG2951	lytic endotransglycosylase activity
E4625_12480	COG3100	YcgL domain-containing protein
E4625_12485	COG0850	regulation of cytokinetic process
E4625_12490	COG2894	cell division
E4625_12495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4625_12505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4625_12545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4625_12550	COG0697	spore germination
E4625_12555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4625_12560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4625_12570	COG0307	riboflavin synthase, alpha
E4625_12580	COG0534	Mate efflux family protein
E4625_12610	COG0417	DNA replication proofreading
E4625_12635	COG1560	Kdo2-lipid A biosynthetic process
E4625_12640	COG1560	Kdo2-lipid A biosynthetic process
E4625_12650	COG0583	DNA-binding transcription factor activity
E4625_12655	COG0673	inositol 2-dehydrogenase activity
E4625_12660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4625_12665	COG0583	DNA-binding transcription factor activity
E4625_12675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4625_12685	COG3300	MHYT domain
E4625_12685	COG5001	Diguanylate cyclase
E4625_12690	COG2723	6-phospho-beta-galactosidase activity
E4625_12695	COG0583	DNA-binding transcription factor activity
E4625_12700	COG3300	MHYT domain
E4625_12700	COG5001	Diguanylate cyclase
E4625_12740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4625_12750	COG2003	Belongs to the UPF0758 family
E4625_12785	COG0730	response to heat
E4625_12795	COG1028	Short-chain dehydrogenase reductase Sdr
E4625_12805	COG1024	Enoyl-CoA hydratase
E4625_12810	COG1024	Enoyl-CoA hydratase
E4625_12815	COG1960	acyl-CoA dehydrogenase activity
E4625_12825	COG1960	acyl-CoA dehydrogenase activity
E4625_12830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4625_12865	COG1584	GPR1 FUN34 yaaH family protein
E4625_12880	COG1115	amino acid carrier protein
E4625_12915	COG1024	Enoyl-CoA hydratase
E4625_12930	COG3162	membrane
E4625_12935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4625_12940	COG0488	(ABC) transporter
E4625_12945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4625_12950	COG0776	regulation of translation
E4625_12955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4625_12960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4625_12965	COG0740	serine-type endopeptidase activity
E4625_12970	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4625_12985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4625_12990	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4625_12995	COG1136	(ABC) transporter
E4625_13000	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4625_13010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4625_13015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4625_13020	COG4166	transmembrane transport
E4625_13025	COG0697	spore germination
E4625_13035	COG2062	phosphohistidine phosphatase, SixA
E4625_13075	COG0519	Catalyzes the synthesis of GMP from XMP
E4625_13075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4625_13080	COG0516	GMP reductase activity
E4625_13080	COG0517	IMP dehydrogenase activity
E4625_13090	COG3158	transport of potassium into the cell
E4625_13110	COG0697	spore germination
E4625_13115	COG1570	exodeoxyribonuclease VII activity
E4625_13130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4625_13135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4625_13140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4625_13160	COG0598	Magnesium transport protein CorA
E4625_13180	COG4771	TonB-dependent receptor
E4625_13185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4625_13190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4625_13195	COG1120	ATPase activity
E4625_13200	COG2977	Belongs to the P-Pant transferase superfamily
E4625_13205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4625_13210	COG3033	Beta-eliminating lyase
E4625_13220	COG3046	protein related to deoxyribodipyrimidine photolyase
E4625_13225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4625_13250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4625_13255	COG0583	DNA-binding transcription factor activity
E4625_13265	COG1335	isochorismatase
E4625_13285	COG4774	siderophore transport
E4625_13290	COG4977	sequence-specific DNA binding
E4625_13300	COG0583	DNA-binding transcription factor activity
E4625_13305	COG2910	NAD(P)H-binding
E4625_13320	COG0612	Peptidase, M16
E4625_13325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4625_13330	COG2076	Multidrug Resistance protein
E4625_13335	COG1944	ATP diphosphatase activity
E4625_13340	COG2116	formate transmembrane transporter activity
E4625_13345	COG1882	Formate acetyltransferase
E4625_13350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4625_13360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4625_13370	COG1840	ABC-type Fe3 transport system, periplasmic component
E4625_13375	COG3842	ATPase activity
E4625_13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4625_13390	COG2983	Belongs to the UPF0260 family
E4625_13400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4625_13405	COG0045	succinate-CoA ligase (ADP-forming) activity
E4625_13410	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4625_13415	COG0567	Dehydrogenase, E1 component
E4625_13425	COG1053	succinate dehydrogenase
E4625_13430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4625_13435	COG2009	succinate dehydrogenase
E4625_13455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4625_13460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4625_13460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4625_13470	COG3069	C4-dicarboxylate transmembrane transporter activity
E4625_13485	COG1451	nucleotide metabolic process
E4625_13500	COG0254	rRNA binding
E4625_13505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4625_13515	COG0583	DNA-binding transcription factor activity
E4625_13525	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4625_13535	COG1879	ABC-type sugar transport system periplasmic component
E4625_13540	COG1069	ribulokinase activity
E4625_13550	COG2160	L-arabinose isomerase activity
E4625_13585	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4625_13595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4625_13630	COG0753	catalase activity
E4625_13685	COG2925	Exonuclease
E4625_13695	COG3345	alpha-galactosidase
E4625_13700	COG1380	Effector of murein hydrolase LrgA
E4625_13705	COG1346	cytolysis
E4625_13710	COG0295	cytidine deaminase activity
E4625_13715	COG1022	Amp-dependent synthetase and ligase
E4625_13730	COG0861	Integral membrane protein TerC family
E4625_13735	COG2885	chlorophyll binding
E4625_13740	COG2199	diguanylate cyclase activity
E4625_13760	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4625_13770	COG3768	UPF0283 membrane protein
E4625_13775	COG3106	COG3106 Predicted ATPase
E4625_13790	COG1842	Phage shock protein A
E4625_13795	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4625_13805	COG4168	peptide transport system, permease
E4625_13810	COG4171	peptide transport system, permease
E4625_13820	COG4172	Belongs to the ABC transporter superfamily
E4625_13830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4625_13835	COG1286	toxin biosynthetic process
E4625_13840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4625_13845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4625_13850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4625_13855	COG0531	amino acid
E4625_13855	COG1674	ftsk spoiiie
E4625_13865	COG0686	Belongs to the AlaDH PNT family
E4625_13870	COG0492	ferredoxin-NADP+ reductase activity
E4625_13875	COG3706	GGDEF domain
E4625_13880	COG3134	Outer membrane lipoprotein
E4625_13885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4625_13890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4625_13895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4625_13900	COG0542	response to heat
E4625_13905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4625_13910	COG1278	Cold shock
E4625_13915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4625_13955	COG3501	Rhs element vgr protein
E4625_14060	COG3501	Rhs element vgr protein
E4625_14075	COG0582	viral genome integration into host DNA
E4625_14080	COG3718	enzyme involved in inositol metabolism
E4625_14090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_14100	COG2176	DNA-directed DNA polymerase activity
E4625_14110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4625_14115	COG0673	inositol 2-dehydrogenase activity
E4625_14160	COG3501	Rhs element vgr protein
E4625_14255	COG4983	Phage plasmid primase, P4 family domain protein
E4625_14305	COG2003	Belongs to the UPF0758 family
E4625_14345	COG2188	Transcriptional regulator
E4625_14350	COG1397	ADP-ribosylglycohydrolase
E4625_14360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_14370	COG1484	DNA-dependent DNA replication
E4625_14375	COG3829	transcription factor binding
E4625_14405	COG1435	thymidine kinase activity
E4625_14410	COG1757	Na H antiporter
E4625_14415	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4625_14420	COG2096	Adenosyltransferase
E4625_14425	COG3530	Putative quorum-sensing-regulated virulence factor
E4625_14430	COG0602	queuosine metabolic process
E4625_14435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4625_14455	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4625_14465	COG0776	regulation of translation
E4625_14470	COG0539	negative regulation of cytoplasmic translation
E4625_14475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4625_14480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4625_14490	COG0583	DNA-binding transcription factor activity
E4625_14510	COG0778	Nitroreductase
E4625_14515	COG5001	Diguanylate cyclase
E4625_14515	COG3300	MHYT domain
E4625_14525	COG0583	DNA-binding transcription factor activity
E4625_14530	COG3437	response regulator, receiver
E4625_14555	COG4989	oxidoreductase activity
E4625_14560	COG0724	RNA recognition motif
E4625_14580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4625_14605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4625_14610	COG1192	Involved in chromosome partitioning
E4625_14620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4625_14625	COG1360	Flagellar Motor Protein
E4625_14630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_14635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_14640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_14640	COG0649	NAD binding
E4625_14655	COG1034	ATP synthesis coupled electron transport
E4625_14660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4625_14665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_14670	COG0839	Belongs to the complex I subunit 6 family
E4625_14675	COG0713	ATP synthesis coupled electron transport
E4625_14685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4625_14690	COG1007	ATP synthesis coupled electron transport
E4625_14705	COG2199	diguanylate cyclase activity
E4625_14705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4625_14710	COG0047	phosphoribosylformylglycinamidine synthase activity
E4625_14710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4625_14715	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4625_14725	COG1645	bacterial-type flagellum-dependent swarming motility
E4625_14730	COG1160	GTP binding
E4625_14735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4625_14740	COG2976	Protein conserved in bacteria
E4625_14745	COG0124	histidyl-tRNA synthetase
E4625_14750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4625_14765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4625_14770	COG0105	UTP biosynthetic process
E4625_14775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4625_14785	COG0633	Ferredoxin
E4625_14790	COG0443	Heat shock 70 kDa protein
E4625_14795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4625_14805	COG0822	iron-sulfur transferase activity
E4625_14810	COG1104	cysteine desulfurase activity
E4625_14855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4625_14860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4625_14865	COG1862	Preprotein translocase
E4625_14870	COG0343	queuine tRNA-ribosyltransferase activity
E4625_14875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4625_14880	COG0517	IMP dehydrogenase activity
E4625_14885	COG0450	alkyl hydroperoxide reductase
E4625_14890	COG3634	alkyl hydroperoxide reductase activity
E4625_14905	COG1393	Belongs to the ArsC family
E4625_14910	COG0798	PFAM Bile acid sodium symporter
E4625_14915	COG0640	Transcriptional regulator
E4625_14920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4625_14920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4625_14925	COG0509	glycine decarboxylation via glycine cleavage system
E4625_14930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4625_14935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4625_14940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4625_14960	COG2814	Major facilitator Superfamily
E4625_14965	COG0625	glutathione transferase activity
E4625_14975	COG0483	inositol monophosphate 1-phosphatase activity
E4625_14995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4625_15035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4625_15040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4625_15060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4625_15060	COG0301	tRNA thio-modification
E4625_15070	COG4953	penicillin-binding protein 1C
E4625_15075	COG2373	Large extracellular alpha-helical protein
E4625_15080	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4625_15090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4625_15105	COG4215	(ABC) transporter
E4625_15110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_15120	COG2431	L-lysine efflux transmembrane transporter activity
E4625_15125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4625_15130	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E4625_15145	COG1393	Belongs to the ArsC family
E4625_15155	COG4783	chaperone-mediated protein folding
E4625_15160	COG0425	Belongs to the sulfur carrier protein TusA family
E4625_15185	COG3842	ATPase activity
E4625_15195	COG1175	transmembrane transport
E4625_15205	COG3081	Nucleoid-associated protein
E4625_15210	COG3082	Protein of unknown function (DUF1414)
E4625_15215	COG3083	sulfuric ester hydrolase activity
E4625_15220	COG4771	TonB-dependent receptor
E4625_15225	COG1770	oligopeptidase
E4625_15245	COG4574	serine-type endopeptidase inhibitor activity
E4625_15250	COG3085	chromosome segregation
E4625_15255	COG0583	DNA-binding transcription factor activity
E4625_15260	COG0287	Prephenate dehydrogenase
E4625_15260	COG1605	Chorismate mutase
E4625_15265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4625_15270	COG0584	glycerophosphoryl diester phosphodiesterase
E4625_15280	COG1349	DNA-binding transcription factor activity
E4625_15285	COG2271	Major facilitator Superfamily
E4625_15290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4625_15295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4625_15300	COG0583	DNA-binding transcription factor activity
E4625_15330	COG0656	L-ascorbic acid biosynthetic process
E4625_15335	COG2814	Major facilitator Superfamily
E4625_15345	COG1294	oxidase, subunit
E4625_15350	COG1271	oxidase subunit
E4625_15355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4625_15365	COG2979	Protein of unknown function (DUF533)
E4625_15390	COG2271	Major facilitator Superfamily
E4625_15395	COG0583	DNA-binding transcription factor activity
E4625_15405	COG2807	transmembrane transport
E4625_15410	COG1187	pseudouridine synthase activity
E4625_15430	COG0346	lactoylglutathione lyase activity
E4625_15440	COG1061	Type III restriction enzyme res subunit
E4625_15450	COG2964	Protein conserved in bacteria
E4625_15455	COG3681	Belongs to the UPF0597 family
E4625_15465	COG0814	amino acid
E4625_15485	COG1166	arginine decarboxylase activity
E4625_15505	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4625_15535	COG0583	DNA-binding transcription factor activity
E4625_15545	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4625_15555	COG0840	transmembrane signaling receptor activity
E4625_15560	COG0302	gtp cyclohydrolase
E4625_15570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4625_15575	COG2267	carboxylic ester hydrolase activity
E4625_15580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4625_15595	COG0314	molybdopterin synthase activity
E4625_15600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4625_15605	COG0315	cyclic pyranopterin monophosphate synthase activity
E4625_15610	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4625_15615	COG3005	denitrification pathway
E4625_15625	COG0348	domain, Protein
E4625_15630	COG0437	4 iron, 4 sulfur cluster binding
E4625_15635	COG0243	molybdopterin cofactor binding
E4625_15645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_15645	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_15650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4625_15655	COG3850	Histidine kinase
E4625_15660	COG2197	response regulator
E4625_15670	COG0784	Response regulator, receiver
E4625_15670	COG2205	protein histidine kinase activity
E4625_15690	COG0121	glutamine amidotransferase
E4625_15695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4625_15700	COG1960	acyl-CoA dehydrogenase activity
E4625_15705	COG0784	Response regulator, receiver
E4625_15705	COG3437	response regulator, receiver
E4625_15715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4625_15720	COG0328	RNA-DNA hybrid ribonuclease activity
E4625_15725	COG2226	methyltransferase
E4625_15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4625_15735	COG1388	LysM domain
E4625_15735	COG0741	lytic transglycosylase activity
E4625_15740	COG3021	interspecies interaction between organisms
E4625_15750	COG1607	acyl-coa hydrolase
E4625_15765	COG0741	lytic transglycosylase activity
E4625_15775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4625_15795	COG2911	Protein conserved in bacteria
E4625_15800	COG0729	surface antigen
E4625_15810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4625_15815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4625_15825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4625_15835	COG4134	Bacterial extracellular solute-binding protein
E4625_15845	COG4136	ATPase activity
E4625_15850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4625_15855	COG2951	lytic endotransglycosylase activity
E4625_15870	COG1846	Transcriptional regulator
E4625_15880	COG0033	Phosphoglucomutase
E4625_15885	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4625_15890	COG0596	Alpha beta hydrolase
E4625_15905	COG0716	FMN binding
E4625_15915	COG0735	belongs to the Fur family
E4625_15920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4625_15930	COG2190	(PTS) system
E4625_15930	COG1263	PTS System
E4625_15930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_15935	COG0363	glucosamine-6-phosphate deaminase activity
E4625_15940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4625_15945	COG1846	Transcriptional regulator
E4625_15945	COG1940	carbohydrate kinase activity
E4625_15950	COG2194	sulfuric ester hydrolase activity
E4625_15955	COG0217	transcriptional regulatory protein
E4625_15960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4625_15965	COG1801	Protein of unknown function DUF72
E4625_15970	COG4106	trans-aconitate 2-methyltransferase activity
E4625_15975	COG0500	methyltransferase
E4625_15995	COG0450	alkyl hydroperoxide reductase
E4625_16000	COG0583	DNA-binding transcription factor activity
E4625_16010	COG0791	NLP P60 protein
E4625_16025	COG1309	transcriptional regulator
E4625_16065	COG0534	Mate efflux family protein
E4625_16085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4625_16085	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4625_16085	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4625_16085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4625_16095	COG3217	Mosc domain protein beta barrel domain protein
E4625_16095	COG3217	Mosc domain protein beta barrel domain protein
E4625_16095	COG0633	Ferredoxin
E4625_16095	COG0633	Ferredoxin
E4625_16105	COG0501	Belongs to the peptidase M48B family
E4625_16110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4625_16115	COG2226	methyltransferase
E4625_16115	COG1073	alpha beta
E4625_16120	COG0156	8-amino-7-oxononanoate synthase activity
E4625_16125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4625_16145	COG0017	Asparaginyl-tRNA synthetase
E4625_16150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4625_16165	COG3069	C4-dicarboxylate transmembrane transporter activity
E4625_16175	COG0583	DNA-binding transcription factor activity
E4625_16180	COG1393	Belongs to the ArsC family
E4625_16185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4625_16190	COG1876	peptidase activity
E4625_16200	COG3263	regulation of cellular component size
E4625_16225	COG1280	lysine exporter protein (LysE YggA)
E4625_16265	COG1454	alcohol dehydrogenase
E4625_16270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4625_16275	COG0702	epimerase
E4625_16285	COG2867	negative regulation of translational initiation
E4625_16290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4625_16300	COG3561	AntA/AntB antirepressor
E4625_16540	COG3645	SOS response
E4625_16540	COG3646	Phage regulatory protein
E4625_16565	COG3646	Phage regulatory protein
E4625_16580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4625_16620	COG2974	May be involved in recombination
E4625_16680	COG1715	Restriction endonuclease
E4625_16685	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4625_16700	COG3171	Protein conserved in bacteria
E4625_16710	COG0583	DNA-binding transcription factor activity
E4625_16715	COG2610	gluconate transmembrane transporter activity
E4625_16720	COG3048	D-serine ammonia-lyase activity
E4625_16730	COG0538	isocitrate dehydrogenase activity
E4625_16735	COG2207	Transcriptional regulator
E4625_16740	COG1482	cell wall glycoprotein biosynthetic process
E4625_16755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_16780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4625_16785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_16785	COG1263	PTS System
E4625_16790	COG1609	Transcriptional regulator
E4625_16805	COG0456	acetyltransferase
E4625_16825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_16825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_16825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_16835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4625_16845	COG1187	pseudouridine synthase activity
E4625_16855	COG0482	sulfurtransferase activity
E4625_16860	COG2915	High frequency lysogenization protein hflD homolog
E4625_16865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4625_16870	COG2850	peptidyl-arginine hydroxylation
E4625_16875	COG3153	acetyltransferase
E4625_16885	COG0625	glutathione transferase activity
E4625_16890	COG0259	pyridoxamine-phosphate oxidase activity
E4625_16905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4625_16905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4625_16910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4625_16925	COG4235	cytochrome complex assembly
E4625_16925	COG3088	subunit of a heme lyase
E4625_16930	COG3088	subunit of a heme lyase
E4625_16930	COG4235	cytochrome complex assembly
E4625_16935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4625_16940	COG1138	Cytochrome C-type biogenesis protein
E4625_16945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4625_16950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4625_16955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4625_16960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4625_16975	COG0835	chemotaxis
E4625_16985	COG1192	Involved in chromosome partitioning
E4625_16990	COG1360	Flagellar Motor Protein
E4625_16995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4625_17000	COG2201	protein-glutamate methylesterase activity
E4625_17005	COG0643	Histidine kinase
E4625_17005	COG2198	Histidine kinase
E4625_17010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4625_17025	COG0455	bacterial-type flagellum organization
E4625_17035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4625_17045	COG1684	flagellar biosynthetic protein fliR
E4625_17050	COG1987	bacterial-type flagellum assembly
E4625_17100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4625_17110	COG1677	Flagellar hook-basal body complex protein FliE
E4625_17125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4625_17140	COG2994	toxin metabolic process
E4625_17150	COG2274	protein secretion by the type I secretion system
E4625_17160	COG2274	protein secretion by the type I secretion system
E4625_17165	COG0745	RESPONSE REGULATOR receiver
E4625_17180	COG1737	Transcriptional regulator
E4625_17185	COG0469	pyruvate kinase activity
E4625_17195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4625_17200	COG1960	acyl-CoA dehydrogenase activity
E4625_17215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4625_17260	COG0243	molybdopterin cofactor binding
E4625_17265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4625_17270	COG0583	DNA-binding transcription factor activity
E4625_17290	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4625_17295	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4625_17300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4625_17305	COG1454	alcohol dehydrogenase
E4625_17305	COG1012	belongs to the aldehyde dehydrogenase family
E4625_17315	COG1454	alcohol dehydrogenase
E4625_17315	COG1012	belongs to the aldehyde dehydrogenase family
E4625_17320	COG1882	Formate acetyltransferase
E4625_17325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4625_17330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4625_17335	COG4869	propanediol catabolic process
E4625_17360	COG1073	alpha beta
E4625_17365	COG0823	Involved in the tonB-independent uptake of proteins
E4625_17365	COG1506	peptidase
E4625_17370	COG0702	epimerase
E4625_17415	COG4409	exo-alpha-(2->6)-sialidase activity
E4625_17420	COG2731	YhcH YjgK YiaL family protein
E4625_17425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4625_17435	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4625_17440	COG1737	Transcriptional regulator
E4625_17445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4625_17450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4625_17455	COG1349	DNA-binding transcription factor activity
E4625_17460	COG0738	Major facilitator superfamily
E4625_17470	COG1070	Carbohydrate kinase
E4625_17490	COG4172	Belongs to the ABC transporter superfamily
E4625_17495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4625_17505	COG0747	negative chemotaxis
E4625_17525	COG1388	LysM domain
E4625_17525	COG1376	ErfK ybiS ycfS ynhG family protein
E4625_17540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4625_17545	COG0791	NLP P60 protein
E4625_17555	COG3118	belongs to the thioredoxin family
E4625_17565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4625_17570	COG0788	formyltetrahydrofolate deformylase activity
E4625_17580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4625_17600	COG0366	Alpha amylase catalytic
E4625_17605	COG0739	heme binding
E4625_17605	COG0741	lytic transglycosylase activity
E4625_17605	COG1196	nuclear chromosome segregation
E4625_17610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4625_17615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4625_17625	COG0673	inositol 2-dehydrogenase activity
E4625_17645	COG3152	Membrane
E4625_17665	COG1032	radical SAM domain protein
E4625_17675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4625_17680	COG1566	PFAM secretion protein HlyD family protein
E4625_17685	COG2199	diguanylate cyclase activity
E4625_17685	COG2203	Gaf domain
E4625_17690	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4625_17695	COG0733	neurotransmitter:sodium symporter activity
E4625_17725	COG0281	malic enzyme
E4625_17735	COG0534	Mate efflux family protein
E4625_17745	COG0745	RESPONSE REGULATOR receiver
E4625_17745	COG3706	GGDEF domain
E4625_17750	COG2233	PERMEase
E4625_17755	COG0095	Lipoate-protein ligase
E4625_17760	COG1115	amino acid carrier protein
E4625_17765	COG0019	diaminopimelate decarboxylase activity
E4625_17775	COG0678	peroxiredoxin activity
E4625_17785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4625_17805	COG1131	(ABC) transporter
E4625_17810	COG0545	Peptidyl-prolyl cis-trans isomerase
E4625_17820	COG3142	Participates in the control of copper homeostasis
E4625_17835	COG4783	chaperone-mediated protein folding
E4625_17845	COG5002	protein histidine kinase activity
E4625_17850	COG0745	RESPONSE REGULATOR receiver
E4625_17855	COG0346	lactoylglutathione lyase activity
E4625_17860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4625_17865	COG1960	acyl-CoA dehydrogenase activity
E4625_17870	COG3284	Transcriptional regulator
E4625_17875	COG1012	belongs to the aldehyde dehydrogenase family
E4625_17885	COG0697	spore germination
E4625_17890	COG4565	transcriptional regulatory protein
E4625_17895	COG3290	protein histidine kinase activity
E4625_17900	COG0281	malic enzyme
E4625_17915	COG1846	Transcriptional regulator
E4625_17920	COG1566	PFAM secretion protein HlyD family protein
E4625_17950	COG0602	queuosine metabolic process
E4625_17955	COG1328	CTP reductase activity
E4625_17965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4625_17970	COG3115	cell septum assembly
E4625_17975	COG1196	nuclear chromosome segregation
E4625_17985	COG2860	membrane
E4625_17995	COG3108	Peptidase M15
E4625_18000	COG2989	Protein conserved in bacteria
E4625_18015	COG0463	Glycosyl transferase, family 2
E4625_18030	COG0366	Alpha amylase catalytic
E4625_18070	COG3706	GGDEF domain
E4625_18080	COG3590	peptidase
E4625_18090	COG0488	(ABC) transporter
E4625_18100	COG0531	amino acid
E4625_18110	COG1234	tRNA 3'-trailer cleavage
E4625_18115	COG0814	amino acid
E4625_18130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4625_18135	COG1982	Orn Lys Arg decarboxylase major
E4625_18140	COG0531	amino acid
E4625_18150	COG3710	Transcriptional regulator
E4625_18160	COG0825	malonyl-CoA metabolic process
E4625_18170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4625_18175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4625_18180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4625_18185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4625_18190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4625_18205	COG0750	zinc metalloprotease
E4625_18210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4625_18215	COG0575	Belongs to the CDS family
E4625_18225	COG0233	cytoplasmic translational termination
E4625_18230	COG0528	UMP kinase activity
E4625_18235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4625_18240	COG0052	Belongs to the universal ribosomal protein uS2 family
E4625_18245	COG0024	Methionine aminopeptidase
E4625_18250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4625_18255	COG2171	N-acyltransferase activity
E4625_18265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_18265	COG1263	PTS System
E4625_18275	COG4580	involved in the transport of maltose and maltodextrins
E4625_18285	COG0564	pseudouridine synthase activity
E4625_18290	COG3098	single-species biofilm formation
E4625_18315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4625_18325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4625_18325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4625_18335	COG3706	GGDEF domain
E4625_18340	COG1611	Belongs to the LOG family
E4625_18345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4625_18350	COG0473	3-isopropylmalate dehydrogenase activity
E4625_18360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4625_18365	COG2363	Small membrane protein
E4625_18375	COG0583	DNA-binding transcription factor activity
E4625_18380	COG0840	transmembrane signaling receptor activity
E4625_18385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4625_18400	COG1477	protein flavinylation
E4625_18405	COG2871	sodium ion transport
E4625_18410	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4625_18415	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4625_18420	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4625_18425	COG1805	sodium ion transport
E4625_18430	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4625_18435	COG0271	Belongs to the BolA IbaG family
E4625_18440	COG2813	Specifically methylates the guanine in position
E4625_18450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4625_18460	COG2211	Major facilitator Superfamily
E4625_18470	COG1666	GTP binding
E4625_18475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4625_18480	COG0693	protein deglycase activity
E4625_18520	COG3501	Rhs element vgr protein
E4625_18535	COG2771	luxR family
E4625_18555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4625_18555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4625_18560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4625_18570	COG1151	hydroxylamine reductase activity
E4625_18575	COG0783	Belongs to the Dps family
E4625_18600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4625_18615	COG4221	oxidoreductase activity
E4625_18625	COG0415	Belongs to the DNA photolyase family
E4625_18630	COG0789	Transcriptional regulator
E4625_18635	COG3272	Protein of unknown function (DUF1722)
E4625_18665	COG0077	Prephenate dehydratase
E4625_18665	COG1605	Chorismate mutase
E4625_18695	COG3710	Transcriptional regulator
E4625_18710	COG5001	Diguanylate cyclase
E4625_18730	COG2373	Large extracellular alpha-helical protein
E4625_18730	COG1388	LysM domain
E4625_18730	COG4932	domain protein
E4625_18740	COG1349	DNA-binding transcription factor activity
E4625_18745	COG2084	Dehydrogenase
E4625_18755	COG0235	Class ii aldolase
E4625_18760	COG3622	Belongs to the hyi family
E4625_18765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4625_18770	COG2610	gluconate transmembrane transporter activity
E4625_18780	COG0840	transmembrane signaling receptor activity
E4625_18790	COG0300	oxidoreductase activity
E4625_18815	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4625_18840	COG0826	peptidase U32
E4625_18845	COG1280	lysine exporter protein (LysE YggA)
E4625_18860	COG0840	transmembrane signaling receptor activity
E4625_18865	COG0745	RESPONSE REGULATOR receiver
E4625_18875	COG0643	Histidine kinase
E4625_18875	COG2198	Histidine kinase
E4625_18885	COG0835	chemotaxis
E4625_18890	COG0840	transmembrane signaling receptor activity
E4625_18900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E4625_18905	COG2201	protein-glutamate methylesterase activity
E4625_18910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4625_18940	COG2197	response regulator
E4625_18965	COG2203	Gaf domain
E4625_18965	COG2200	EAL domain
E4625_18965	COG2199	diguanylate cyclase activity
E4625_18975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4625_18985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4625_18990	COG0305	Participates in initiation and elongation during chromosome replication
E4625_19005	COG2200	EAL domain
E4625_19010	COG0737	Belongs to the 5'-nucleotidase family
E4625_19030	COG2204	response regulator
E4625_19035	COG0545	Peptidyl-prolyl cis-trans isomerase
E4625_19045	COG2900	Belongs to the SlyX family
E4625_19050	COG1047	Peptidyl-prolyl cis-trans
E4625_19055	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4625_19065	COG0784	Response regulator, receiver
E4625_19065	COG0835	chemotaxis
E4625_19070	COG0429	hydrolase of the alpha beta-hydrolase fold
E4625_19075	COG5001	Diguanylate cyclase
E4625_19075	COG2203	Gaf domain
E4625_19075	COG3706	GGDEF domain
E4625_19075	COG4251	negative regulation of phosphorylation
E4625_19080	COG3089	Belongs to the UPF0270 family
E4625_19090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4625_19095	COG0463	Glycosyl transferase, family 2
E4625_19100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4625_19100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4625_19105	COG0726	polysaccharide deacetylase
E4625_19110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4625_19115	COG2076	Multidrug Resistance protein
E4625_19120	COG2076	Multidrug Resistance protein
E4625_19125	COG3954	Phosphoribulokinase
E4625_19140	COG1765	OsmC-like protein
E4625_19145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4625_19150	COG2226	methyltransferase
E4625_19160	COG3397	chitin binding
E4625_19175	COG2205	protein histidine kinase activity
E4625_19175	COG2202	Pas domain
E4625_19185	COG3655	Transcriptional regulator
E4625_19190	COG2814	Major facilitator Superfamily
E4625_19200	COG4771	TonB-dependent receptor
E4625_19220	COG0748	coenzyme F420 binding
E4625_19225	COG3721	Heme iron utilization protein
E4625_19235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4625_19260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4625_19265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4625_19270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4625_19290	COG0741	lytic transglycosylase activity
E4625_19295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4625_19310	COG0488	(ABC) transporter
E4625_19320	COG2252	PERMEase
E4625_19325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4625_19330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4625_19335	COG3178	'Phosphotransferase
E4625_19340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4625_19350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4625_19355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4625_19365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4625_19375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4625_19380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4625_19395	COG0318	PFAM AMP-dependent synthetase and ligase
E4625_19405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4625_19410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4625_19415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4625_19420	COG0142	geranyltranstransferase activity
E4625_19425	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4625_19430	COG0330	HflC and HflK could
E4625_19435	COG0330	HflC and HflK could
E4625_19440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4625_19445	COG1923	regulation of RNA biosynthetic process
E4625_19450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4625_19455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4625_19465	COG0802	atpase or kinase
E4625_19470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4625_19470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4625_19475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4625_19495	COG2011	ABC-type metal ion transport system permease component
E4625_19500	COG1464	Belongs to the NlpA lipoprotein family
E4625_19510	COG0840	transmembrane signaling receptor activity
E4625_19535	COG0784	Response regulator, receiver
E4625_19535	COG5002	protein histidine kinase activity
E4625_19535	COG2198	Histidine kinase
E4625_19555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E4625_19570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4625_19575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4625_19585	COG2716	regulation of RNA biosynthetic process
E4625_19590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4625_19595	COG3013	Belongs to the UPF0304 family
E4625_19600	COG3092	negative regulation of chromosome organization
E4625_19605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4625_19610	COG0857	belongs to the CobB CobQ family
E4625_19610	COG0280	phosphate acetyltransferase
E4625_19625	COG0028	Belongs to the TPP enzyme family
E4625_19640	COG0671	phosphoesterase, PA-phosphatase related
E4625_19650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4625_19655	COG0473	3-isopropylmalate dehydrogenase activity
E4625_19660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4625_19665	COG0066	3-isopropylmalate dehydratase activity
E4625_19680	COG4143	(ABC) transporter
E4625_19685	COG1178	ABC-type Fe3 transport system permease component
E4625_19690	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4625_19695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4625_19705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4625_19735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4625_19740	COG0564	pseudouridine synthase activity
E4625_19750	COG5001	Diguanylate cyclase
E4625_19750	COG3300	MHYT domain
E4625_19760	COG0459	protein refolding
E4625_19765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4625_19770	COG0534	Mate efflux family protein
E4625_19775	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4625_19780	COG1027	Aspartate ammonia-lyase
E4625_19785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4625_19795	COG0477	Major facilitator Superfamily
E4625_19810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4625_19815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4625_19825	COG0673	inositol 2-dehydrogenase activity
E4625_19835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4625_19840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4625_19845	COG3036	rescue of stalled ribosome
E4625_19850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4625_19860	COG0138	bifunctional purine biosynthesis protein purh
E4625_19865	COG0151	Belongs to the GarS family
E4625_19965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4625_19985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4625_19990	COG0358	DNA primase activity
E4625_19995	COG1610	YqeY-like protein
E4625_20000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4625_20005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4625_20015	COG1388	LysM domain
E4625_20015	COG4942	peptidase
E4625_20020	COG1238	metal cluster binding
E4625_20025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4625_20030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4625_20035	COG0585	pseudouridine synthase activity
E4625_20045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4625_20050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4625_20055	COG0148	phosphopyruvate hydratase activity
E4625_20060	COG0504	CTP synthase activity
E4625_20065	COG3956	TIGRFAM MazG family protein
E4625_20070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4625_20075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4625_20085	COG4807	Protein conserved in bacteria
E4625_20090	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4625_20095	COG1349	DNA-binding transcription factor activity
E4625_20105	COG2222	sugar isomerase
E4625_20110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_20120	COG3716	PTS system mannose fructose sorbose family IID component
E4625_20125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_20130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4625_20145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4625_20150	COG1381	Involved in DNA repair and RecF pathway recombination
E4625_20160	COG0571	ribonuclease III activity
E4625_20165	COG0681	Belongs to the peptidase S26 family
E4625_20170	COG0481	GTPase activity
E4625_20185	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4625_20190	COG1595	DNA-templated transcription, initiation
E4625_20195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4625_20205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4625_20245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4625_20255	COG0126	phosphoglycerate kinase activity
E4625_20260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4625_20265	COG1940	carbohydrate kinase activity
E4625_20270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4625_20285	COG4991	sh3 domain protein
E4625_20290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4625_20305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4625_20330	COG1505	serine-type exopeptidase activity
E4625_20335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4625_20340	COG0765	amino acid transport
E4625_20345	COG0765	amino acid transport
E4625_20350	COG1126	abc transporter atp-binding protein
E4625_20355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_20360	COG0577	efflux transmembrane transporter activity
E4625_20360	COG1136	(ABC) transporter
E4625_20365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4625_20370	COG0745	RESPONSE REGULATOR receiver
E4625_20375	COG2205	protein histidine kinase activity
E4625_20380	COG2816	NAD+ diphosphatase activity
E4625_20415	COG2070	2-Nitropropane dioxygenase
E4625_20440	COG1858	cytochrome C peroxidase
E4625_20445	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4625_20465	COG0513	Belongs to the DEAD box helicase family
E4625_20485	COG0154	amidase activity
E4625_20490	COG2957	Belongs to the agmatine deiminase family
E4625_20505	COG1902	pentaerythritol trinitrate reductase activity
E4625_20535	COG3706	GGDEF domain
E4625_20535	COG0745	RESPONSE REGULATOR receiver
E4625_20545	COG3300	MHYT domain
E4625_20545	COG5001	Diguanylate cyclase
E4625_20555	COG0714	Associated with various cellular activities
E4625_20565	COG0456	acetyltransferase
E4625_20575	COG1022	Amp-dependent synthetase and ligase
E4625_20585	COG2918	glutathione biosynthetic process
E4625_20590	COG0612	Peptidase, M16
E4625_20595	COG1238	metal cluster binding
E4625_20620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4625_20625	COG0359	binds to the 23S rRNA
E4625_20630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4625_20635	COG0360	Binds together with S18 to 16S ribosomal RNA
E4625_20640	COG1914	H( )-stimulated, divalent metal cation uptake system
E4625_20660	COG2153	protein acetylation
E4625_20670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4625_20675	COG0557	exoribonuclease II activity
E4625_20680	COG3706	GGDEF domain
E4625_20685	COG1854	S-ribosylhomocysteine lyase activity
E4625_20700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4625_20700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4625_20760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4625_20765	COG1047	Peptidyl-prolyl cis-trans
E4625_20770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4625_20775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4625_20780	COG0196	riboflavin kinase activity
E4625_20785	COG0728	peptidoglycan biosynthetic process
E4625_20790	COG0268	Binds directly to 16S ribosomal RNA
E4625_20795	COG0640	Transcriptional regulator
E4625_20800	COG0583	DNA-binding transcription factor activity
E4625_20810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4625_20815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4625_20820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4625_20830	COG1051	belongs to the nudix hydrolase family
E4625_20835	COG3066	DNA modification
E4625_20845	COG0335	large ribosomal subunit rRNA binding
E4625_20850	COG0336	Belongs to the RNA methyltransferase TrmD family
E4625_20855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4625_20860	COG0228	four-way junction DNA binding
E4625_20865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4625_20870	COG4137	Cytochrome C assembly protein
E4625_20875	COG4536	flavin adenine dinucleotide binding
E4625_20885	COG1017	nitric oxide dioxygenase activity
E4625_20885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4625_20890	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4625_20895	COG0039	L-malate dehydrogenase activity
E4625_20900	COG4160	amino acid transport
E4625_20905	COG4215	(ABC) transporter
E4625_20910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4625_20915	COG1126	abc transporter atp-binding protein
E4625_20920	COG1438	arginine binding
E4625_20925	COG2837	iron assimilation
E4625_20930	COG3842	ATPase activity
E4625_20940	COG1840	ABC-type Fe3 transport system, periplasmic component
E4625_20945	COG0347	Belongs to the P(II) protein family
E4625_20960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4625_20965	COG0583	DNA-binding transcription factor activity
E4625_20980	COG1929	Belongs to the glycerate kinase type-1 family
E4625_20985	COG2610	gluconate transmembrane transporter activity
E4625_20990	COG3835	regulator
E4625_21000	COG3112	Uncharacterised protein family (UPF0231)
E4625_21015	COG0840	transmembrane signaling receptor activity
E4625_21020	COG3568	Endonuclease Exonuclease Phosphatase
E4625_21035	COG0513	Belongs to the DEAD box helicase family
E4625_21075	COG1448	Aminotransferase
E4625_21090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4625_21095	COG1328	CTP reductase activity
E4625_21115	COG4946	Tricorn protease homolog
E4625_21115	COG0793	Belongs to the peptidase S41A family
E4625_21145	COG0840	transmembrane signaling receptor activity
E4625_21150	COG3397	chitin binding
E4625_21155	COG0583	DNA-binding transcription factor activity
E4625_21160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4625_21165	COG4208	sulfate ABC transporter
E4625_21170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4625_21180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4625_21185	COG3174	membrane
E4625_21190	COG0110	maltose O-acetyltransferase activity
E4625_21215	COG0165	Argininosuccinate lyase
E4625_21220	COG0137	argininosuccinate synthase activity
E4625_21230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4625_21235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4625_21245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4625_21250	COG3621	Patatin-like phospholipase
E4625_21260	COG3436	PFAM IS66 Orf2 family protein
E4625_21265	COG4372	Transposase
E4625_21280	COG0460	homoserine dehydrogenase
E4625_21280	COG0527	aspartate kinase activity
E4625_21285	COG0626	cystathionine gamma-synthase activity
E4625_21295	COG3708	Transcriptional regulator
E4625_21295	COG2207	Transcriptional regulator
E4625_21300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4625_21305	COG0814	amino acid
E4625_21310	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4625_21315	COG0494	nUDIX hydrolase
E4625_21320	COG1011	Hydrolase
E4625_21325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4625_21340	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4625_21350	COG3156	type II secretion system protein K
E4625_21360	COG4795	General secretion pathway protein
E4625_21365	COG2165	general secretion pathway protein
E4625_21380	COG2165	general secretion pathway protein
E4625_21385	COG1459	type II secretion system
E4625_21390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4625_21400	COG3031	protein transport across the cell outer membrane
E4625_21410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4625_21435	COG0456	acetyltransferase
E4625_21440	COG3133	Outer membrane lipoprotein
E4625_21455	COG2771	luxR family
E4625_21460	COG3916	Acyl-homoserine-lactone synthase
E4625_21470	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4625_21475	COG1309	transcriptional regulator
E4625_21485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4625_21485	COG2213	PTS system mannitol-specific
E4625_21490	COG0246	Mannitol dehydrogenase
E4625_21495	COG3722	fumarate hydratase activity
E4625_21500	COG3263	regulation of cellular component size
E4625_21525	COG1671	Belongs to the UPF0178 family
E4625_21540	COG1988	membrane-bound metal-dependent
E4625_21545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4625_21550	COG0513	Belongs to the DEAD box helicase family
E4625_21575	COG1575	Belongs to the MenA family. Type 1 subfamily
E4625_21580	COG1169	isochorismate synthase
E4625_21585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4625_21590	COG0596	Alpha beta hydrolase
E4625_21595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4625_21600	COG1441	menaquinone biosynthetic process
E4625_21620	COG3539	Fimbrial protein
E4625_21630	COG3188	usher protein
E4625_21640	COG3539	Fimbrial protein
E4625_21655	COG3291	Pkd domain containing protein
E4625_21660	COG2949	membrane
E4625_21680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4625_21685	COG5380	lipid catabolic process
E4625_21700	COG4533	DNA binding
E4625_21710	COG2873	o-acetylhomoserine
E4625_21720	COG1979	alcohol dehydrogenase
E4625_21740	COG4221	oxidoreductase activity
E4625_21760	COG1285	pathogenesis
E4625_21780	COG1368	sulfuric ester hydrolase activity
E4625_21785	COG1522	sequence-specific DNA binding
E4625_21795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4625_21800	COG1418	mRNA catabolic process
E4625_21805	COG1058	Belongs to the CinA family
E4625_21805	COG1546	Belongs to the CinA family
E4625_21815	COG0842	Transport permease protein
E4625_21815	COG1129	ABC transporter
E4625_21830	COG0561	phosphatase activity
E4625_21835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4625_21855	COG1011	Hydrolase
E4625_21870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4625_21875	COG0019	diaminopimelate decarboxylase activity
E4625_21885	COG1965	Belongs to the frataxin family
E4625_21890	COG0400	carboxylic ester hydrolase activity
E4625_21895	COG3072	Adenylate cyclase
E4625_21900	COG0181	hydroxymethylbilane synthase activity
E4625_21905	COG1587	Uroporphyrinogen-III synthase
E4625_21910	COG2959	enzyme of heme biosynthesis
E4625_21925	COG1494	fructose-1,6-bisphosphatase
E4625_21965	COG1733	regulation of RNA biosynthetic process
E4625_21985	COG3932	Exopolysaccharide synthesis, ExoD
E4625_21990	COG0814	amino acid
E4625_21995	COG3706	GGDEF domain
E4625_22010	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4625_22045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4625_22050	COG2022	thiamine diphosphate biosynthetic process
E4625_22060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4625_22065	COG0352	thiamine-phosphate diphosphorylase activity
E4625_22070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4625_22090	COG0745	RESPONSE REGULATOR receiver
E4625_22100	COG1114	Component of the transport system for branched-chain amino acids
E4625_22105	COG0189	ligase activity
E4625_22130	COG1639	'signal transduction protein
E4625_22140	COG2321	neutral zinc metallopeptidase
E4625_22145	COG3700	Belongs to the class B bacterial acid phosphatase family
E4625_22165	COG1366	Belongs to the anti-sigma-factor antagonist family
E4625_22170	COG2172	sigma factor antagonist activity
E4625_22175	COG5002	protein histidine kinase activity
E4625_22175	COG2205	protein histidine kinase activity
E4625_22175	COG0784	Response regulator, receiver
E4625_22180	COG3437	response regulator, receiver
E4625_22190	COG0477	Major facilitator Superfamily
E4625_22210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4625_22215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4625_22215	COG1263	PTS System
E4625_22240	COG0312	modulator of DNA gyrase
E4625_22245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4625_22255	COG3164	Protein of unknown function
E4625_22260	COG1530	ribonuclease E activity
E4625_22265	COG0424	maF-like protein
E4625_22270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4625_22275	COG1792	Involved in formation and maintenance of cell shape
E4625_22280	COG1077	Cell shape determining protein MreB Mrl
E4625_22305	COG4968	Prepilin-type N-terminal cleavage methylation domain
E4625_22325	COG1459	type II secretion system
E4625_22330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4625_22375	COG2200	EAL domain
E4625_22375	COG2199	diguanylate cyclase activity
E4625_22380	COG2200	EAL domain
E4625_22385	COG0387	Pfam Sodium calcium exchanger
E4625_22390	COG2986	histidine ammonia-lyase
E4625_22395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4625_22400	COG0010	Belongs to the arginase family
E4625_22405	COG1228	amidohydrolase
E4625_22410	COG2188	Transcriptional regulator
E4625_22415	COG0288	reversible hydration of carbon dioxide
E4625_22425	COG2177	Part of the ABC transporter FtsEX involved in
E4625_22430	COG2884	Cell division ATP-binding protein ftsE
E4625_22435	COG0552	protein localization to endoplasmic reticulum
E4625_22440	COG0742	ribosomal rna small subunit methyltransferase
E4625_22465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4625_22470	COG0741	lytic transglycosylase activity
E4625_22490	COG2095	MarC family integral membrane protein
E4625_22500	COG1301	dicarboxylic acid transport
E4625_22525	COG3714	YhhN family
E4625_22550	COG1770	oligopeptidase
E4625_22565	COG4221	oxidoreductase activity
E4625_22570	COG0583	DNA-binding transcription factor activity
E4625_22575	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4625_22630	COG0203	ribosomal protein L17
E4625_22635	COG0202	RNA polymerase activity
E4625_22640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4625_22645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4625_22650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4625_22655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4625_22660	COG0201	protein transport
E4625_22665	COG0200	Binds to the 23S rRNA
E4625_22670	COG1841	ribosomal large subunit assembly
E4625_22675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4625_22680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4625_22685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4625_22690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4625_22695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4625_22700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4625_22705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4625_22710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4625_22715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4625_22720	COG0255	Belongs to the universal ribosomal protein uL29 family
E4625_22725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4625_22730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4625_22735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4625_22740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4625_22745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4625_22750	COG0089	rRNA binding
E4625_22755	COG0088	Forms part of the polypeptide exit tunnel
E4625_22760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4625_22765	COG0051	transcription antitermination factor activity, RNA binding
E4625_22780	COG0745	RESPONSE REGULATOR receiver
E4625_22785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4625_22790	COG2183	response to ionizing radiation
E4625_22810	COG0596	Alpha beta hydrolase
E4625_22815	COG1040	competence protein
E4625_22820	COG0316	Belongs to the HesB IscA family
E4625_22820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4625_22825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4625_22830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4625_22835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4625_22840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4625_22845	COG4942	peptidase
E4625_22855	COG1609	Transcriptional regulator
E4625_22860	COG0800	Aldolase
E4625_22865	COG0129	dihydroxy-acid dehydratase activity
E4625_22870	COG3265	gluconokinase activity
E4625_22875	COG2610	gluconate transmembrane transporter activity
E4625_22880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4625_22885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4625_22895	COG0456	acetyltransferase
E4625_22905	COG1490	D-aminoacyl-tRNA deacylase activity
E4625_22910	COG1295	ribonuclease BN
E4625_22915	COG1295	ribonuclease BN
E4625_22925	COG0174	glutamine synthetase
E4625_22935	COG3852	Histidine kinase
E4625_22940	COG2204	response regulator
E4625_22945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4625_22950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4625_22960	COG3078	GTPase activator activity
E4625_22975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4625_22985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4625_22990	COG0408	coproporphyrinogen oxidase activity
E4625_22995	COG0009	L-threonylcarbamoyladenylate synthase
E4625_23005	COG0551	DNA topoisomerase type I activity
E4625_23010	COG2922	Belongs to the Smg family
E4625_23015	COG0758	DNA mediated transformation
E4625_23025	COG0242	peptide deformylase activity
E4625_23030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4625_23035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4625_23035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4625_23040	COG0569	domain protein
E4625_23045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4625_23050	COG1322	Protein conserved in bacteria
E4625_23070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4625_23075	COG0686	Belongs to the AlaDH PNT family
E4625_23080	COG0519	Catalyzes the synthesis of GMP from XMP
E4625_23080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4625_23095	COG1396	sequence-specific DNA binding
E4625_23100	COG1012	belongs to the aldehyde dehydrogenase family
E4625_23110	COG2962	Rard protein
E4625_23120	COG1280	lysine exporter protein (LysE YggA)
E4625_23135	COG2391	methyltransferase activity
E4625_23145	COG1280	lysine exporter protein (LysE YggA)
E4625_23195	COG0583	DNA-binding transcription factor activity
E4625_23215	COG0210	DNA helicase
E4625_23240	COG0583	DNA-binding transcription factor activity
E4625_23260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4625_23265	COG0385	Bile acid
E4625_23270	COG0531	amino acid
E4625_23275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4625_23280	COG0531	amino acid
E4625_23285	COG2731	YhcH YjgK YiaL family protein
E4625_23290	COG3250	beta-galactosidase activity
E4625_23295	COG1609	Transcriptional regulator
E4625_23335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4625_23340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4625_23340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4625_23350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4625_23355	COG3074	FtsZ-dependent cytokinesis
E4625_23365	COG1045	serine acetyltransferase
E4625_23375	COG0745	RESPONSE REGULATOR receiver
E4625_23380	COG2205	protein histidine kinase activity
E4625_23385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4625_23390	COG0534	Mate efflux family protein
E4625_23415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4625_23420	COG2937	Belongs to the GPAT DAPAT family
E4625_23425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4625_23430	COG3161	chorismate lyase activity
E4625_23435	COG1580	Controls the rotational direction of flagella during chemotaxis
E4625_23455	COG0604	alcohol dehydrogenase
E4625_23460	COG1609	Transcriptional regulator
E4625_23480	COG1519	Transferase
E4625_23485	COG0859	PFAM glycosyl transferase family 9
E4625_23490	COG0463	Glycosyl transferase, family 2
E4625_23495	COG0859	PFAM glycosyl transferase family 9
E4625_23500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4625_23505	COG2990	Protein conserved in bacteria
E4625_23510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4625_23520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4625_23525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4625_23530	COG2003	Belongs to the UPF0758 family
E4625_23535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4625_23540	COG0756	dUTP diphosphatase activity
E4625_23545	COG1309	transcriptional regulator
E4625_23550	COG0668	transmembrane transport
E4625_23565	COG0166	Belongs to the GPI family
E4625_23570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4625_23575	COG0583	DNA-binding transcription factor activity
E4625_23590	COG1042	CoA-binding domain protein
E4625_23590	COG0045	succinate-CoA ligase (ADP-forming) activity
E4625_23590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4625_23615	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4625_23620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4625_23625	COG1739	Uncharacterized protein family UPF0029
E4625_23630	COG0006	proline dipeptidase activity
E4625_23635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4625_23640	COG1024	Enoyl-CoA hydratase
E4625_23640	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4625_23645	COG0183	Belongs to the thiolase family
E4625_23650	COG0745	RESPONSE REGULATOR receiver
E4625_23655	COG2205	protein histidine kinase activity
E4625_23670	COG0425	Belongs to the sulfur carrier protein TusA family
E4625_23675	COG0251	oxidation-reduction process
E4625_23685	COG2885	chlorophyll binding
E4625_23695	COG2818	Glycosylase
E4625_23700	COG0752	glycyl-tRNA synthetase alpha subunit
E4625_23705	COG0751	glycine-tRNA ligase activity
E4625_23715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4625_23735	COG0814	amino acid
E4625_23740	COG0348	domain, Protein
E4625_23750	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4625_23755	COG0426	domain, Protein
E4625_23755	COG1773	rubredoxin
E4625_23760	COG3604	Transcriptional regulator
E4625_23765	COG2188	Transcriptional regulator
E4625_23780	COG1609	Transcriptional regulator
E4625_23790	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4625_23820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4625_23845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4625_23855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4625_23860	COG3118	belongs to the thioredoxin family
E4625_23865	COG0513	Belongs to the DEAD box helicase family
E4625_23870	COG0248	Ppx GppA phosphatase
E4625_23885	COG0742	ribosomal rna small subunit methyltransferase
E4625_23905	COG0084	hydrolase, TatD family'
E4625_23910	COG0805	protein transport
E4625_23915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4625_23925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4625_23930	COG3165	ubiquinone biosynthetic process from chorismate
E4625_23940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4625_23945	COG0402	S-adenosylhomocysteine deaminase activity
E4625_23985	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4625_23990	COG0848	biopolymer transport protein
E4625_23995	COG0811	peptide transport
E4625_24000	COG0811	peptide transport
E4625_24010	COG2771	luxR family
E4625_24015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4625_24020	COG1349	DNA-binding transcription factor activity
E4625_24025	COG0745	RESPONSE REGULATOR receiver
E4625_24030	COG2205	protein histidine kinase activity
E4625_24040	COG4452	Inner membrane protein CreD
E4625_24045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4625_24050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4625_24055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4625_24060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4625_24065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4625_24070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4625_24075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4625_24085	COG0356	it plays a direct role in the translocation of protons across the membrane
E4625_24095	COG1475	DNA binding
E4625_24100	COG1192	Involved in chromosome partitioning
E4625_24105	COG0357	Ribosomal RNA small subunit methyltransferase G
E4625_24110	COG0445	tRNA wobble uridine modification
E4625_24115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4625_24120	COG4774	siderophore transport
E4625_24125	COG4615	Cyclic peptide transporter
E4625_24130	COG1120	ATPase activity
E4625_24145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4625_24150	COG0706	membrane insertase activity
E4625_24155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4625_24160	COG0594	ribonuclease P activity
E4625_24165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4625_24190	COG5001	Diguanylate cyclase
E4625_24225	COG0714	Associated with various cellular activities
E4625_24235	COG0629	single-stranded DNA binding
E4625_24285	COG0633	Ferredoxin
E4625_24425	COG1357	PFAM Pentapeptide repeats (8 copies)
E4625_24475	COG3316	Transposase and inactivated derivatives
E4625_24500	COG3173	Aminoglycoside phosphotransferase
E4625_24510	COG3316	Transposase and inactivated derivatives
E4625_24530	COG3436	PFAM IS66 Orf2 family protein
E4625_24535	COG4372	Transposase
E4625_24655	COG4974	Belongs to the 'phage' integrase family
E4625_24810	COG0616	signal peptide processing
E4625_24860	COG0776	regulation of translation
E4625_24925	COG3316	Transposase and inactivated derivatives
E4625_24935	COG3316	Transposase and inactivated derivatives
E4625_25025	COG1192	Involved in chromosome partitioning
E4625_25105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4625_25220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process