locus-tag	class	description
AI20_00015	COG1444	tRNA N-acetyltransferase activity
AI20_00040	COG1803	Methylglyoxal synthase
AI20_00055	COG0252	asparaginase activity
AI20_00080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_00080	COG1263	PTS System
AI20_00085	COG0366	Alpha amylase catalytic
AI20_00090	COG0110	maltose O-acetyltransferase activity
AI20_00115	COG1012	belongs to the aldehyde dehydrogenase family
AI20_00120	COG1177	transmembrane transport
AI20_00130	COG1176	ABC-type spermidine putrescine transport system, permease component I
AI20_00135	COG3842	ATPase activity
AI20_00145	COG1757	Na H antiporter
AI20_00185	COG0297	glycogen (starch) synthase activity
AI20_00190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AI20_00195	COG2813	Specifically methylates the guanine in position
AI20_00200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AI20_00205	COG5001	Diguanylate cyclase
AI20_00205	COG2203	Gaf domain
AI20_00205	COG3706	GGDEF domain
AI20_00205	COG4251	negative regulation of phosphorylation
AI20_00215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_00225	COG2995	paraquat-inducible protein a
AI20_00230	COG3008	intermembrane lipid transfer
AI20_00230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AI20_00235	COG3009	Protein conserved in bacteria
AI20_00240	COG2885	chlorophyll binding
AI20_00240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AI20_00250	COG3240	lipase activity
AI20_00255	COG3111	PFAM Bacterial OB fold (BOF) protein
AI20_00265	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AI20_00270	COG1194	a g-specific adenine glycosylase
AI20_00280	COG3409	Peptidoglycan-binding domain 1 protein
AI20_00280	COG3267	Type II secretory pathway component ExeA
AI20_00285	COG0617	tRNA 3'-terminal CCA addition
AI20_00300	COG1346	cytolysis
AI20_00305	COG1380	Effector of murein hydrolase LrgA
AI20_00310	COG0583	DNA-binding transcription factor activity
AI20_00340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AI20_00345	COG0306	phosphate transporter
AI20_00350	COG1392	Phosphate transport regulator
AI20_00365	COG1560	Kdo2-lipid A biosynthetic process
AI20_00370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AI20_00370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AI20_00375	COG1538	Outer membrane efflux protein
AI20_00380	COG0494	nUDIX hydrolase
AI20_00385	COG3151	Protein conserved in bacteria
AI20_00395	COG3150	esterase
AI20_00400	COG1051	belongs to the nudix hydrolase family
AI20_00415	COG1566	PFAM secretion protein HlyD family protein
AI20_00420	COG1289	transmembrane transporter activity
AI20_00425	COG0187	DNA topoisomerase II activity
AI20_00435	COG0583	DNA-binding transcription factor activity
AI20_00445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AI20_00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_00515	COG0204	Acyl-transferase
AI20_00520	COG1842	Phage shock protein A
AI20_00535	COG2827	Endonuclease containing a URI domain
AI20_00545	COG2962	Rard protein
AI20_00550	COG1573	uracil-dna glycosylase
AI20_00555	COG0697	spore germination
AI20_00560	COG0583	DNA-binding transcription factor activity
AI20_00565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AI20_00570	COG1121	(ABC) transporter
AI20_00575	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AI20_00595	COG0739	heme binding
AI20_00605	COG3068	Protein conserved in bacteria
AI20_00625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AI20_00650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AI20_00690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AI20_00715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_00720	COG2003	Belongs to the UPF0758 family
AI20_00755	COG5377	YqaJ viral recombinase family
AI20_00765	COG1546	Belongs to the CinA family
AI20_00770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AI20_00780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AI20_00785	COG0527	aspartate kinase activity
AI20_00790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AI20_00825	COG1686	Belongs to the peptidase S11 family
AI20_00830	COG0586	Pfam SNARE associated Golgi protein
AI20_00835	COG1253	flavin adenine dinucleotide binding
AI20_00840	COG0525	valine-tRNA ligase activity
AI20_00845	COG2927	DNA polymerase III (CHI subunit)
AI20_00850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_00855	COG0795	lipopolysaccharide-transporting ATPase activity
AI20_00865	COG0795	lipopolysaccharide-transporting ATPase activity
AI20_00880	COG0004	ammonium transporteR
AI20_00885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_00900	COG0084	hydrolase, TatD family'
AI20_00905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_00915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AI20_00920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AI20_00925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AI20_00930	COG0813	purine-nucleoside phosphorylase activity
AI20_00935	COG5002	protein histidine kinase activity
AI20_00935	COG5001	Diguanylate cyclase
AI20_00935	COG3447	MASE1 domain protein
AI20_00945	COG0560	Phosphoserine phosphatase
AI20_00975	COG0776	regulation of translation
AI20_00990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AI20_01020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AI20_01025	COG0513	Belongs to the DEAD box helicase family
AI20_01030	COG3022	response to hydroperoxide
AI20_01035	COG2805	Type II/IV secretion system protein
AI20_01045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AI20_01050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AI20_01055	COG0762	integral membrane protein
AI20_01060	COG1872	DUF167
AI20_01075	COG4166	transmembrane transport
AI20_01085	COG0110	maltose O-acetyltransferase activity
AI20_01095	COG1024	Enoyl-CoA hydratase
AI20_01110	COG4221	oxidoreductase activity
AI20_01115	COG0442	prolyl-tRNA aminoacylation
AI20_01120	COG0840	transmembrane signaling receptor activity
AI20_01125	COG0632	four-way junction helicase activity
AI20_01130	COG2255	four-way junction helicase activity
AI20_01135	COG1271	oxidase subunit
AI20_01140	COG1294	oxidase, subunit
AI20_01145	COG4890	Cyd operon protein YbgT
AI20_01150	COG3790	cyd operon protein YbgE
AI20_01155	COG0824	Thioesterase
AI20_01160	COG0811	peptide transport
AI20_01175	COG0823	Involved in the tonB-independent uptake of proteins
AI20_01180	COG2885	chlorophyll binding
AI20_01185	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AI20_01260	COG0840	transmembrane signaling receptor activity
AI20_01265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AI20_01270	COG0676	glucose-6-phosphate 1-epimerase activity
AI20_01275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AI20_01280	COG1640	4-alpha-glucanotransferase
AI20_01285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AI20_01305	COG1051	belongs to the nudix hydrolase family
AI20_01310	COG2130	NADP-dependent
AI20_01315	COG1846	Transcriptional regulator
AI20_01330	COG1522	sequence-specific DNA binding
AI20_01345	COG0561	phosphatase activity
AI20_01360	COG0733	neurotransmitter:sodium symporter activity
AI20_01370	COG0733	neurotransmitter:sodium symporter activity
AI20_01395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_01410	COG1794	racemase activity, acting on amino acids and derivatives
AI20_01425	COG2731	YhcH YjgK YiaL family protein
AI20_01435	COG0668	transmembrane transport
AI20_01445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AI20_01485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AI20_01495	COG0488	(ABC) transporter
AI20_01500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AI20_01500	COG0517	IMP dehydrogenase activity
AI20_01505	COG1585	Membrane protein implicated in regulation of membrane protease activity
AI20_01510	COG0330	HflC and HflK could
AI20_01515	COG1648	precorrin-2 dehydrogenase activity
AI20_01515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AI20_01520	COG0175	sulfate reduction
AI20_01525	COG2895	sulfate adenylyltransferase (ATP) activity
AI20_01530	COG0471	metal ion transport
AI20_01530	COG3273	potassium ion transport
AI20_01535	COG0529	Catalyzes the synthesis of activated sulfate
AI20_01555	COG0840	transmembrane signaling receptor activity
AI20_01590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AI20_01605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AI20_01610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AI20_01615	COG0163	prenyltransferase activity
AI20_01630	COG1131	(ABC) transporter
AI20_01635	COG0842	Transport permease protein
AI20_01640	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AI20_01645	COG1924	4 iron, 4 sulfur cluster binding
AI20_01665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AI20_01670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AI20_01675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AI20_01680	COG0617	tRNA 3'-terminal CCA addition
AI20_01685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_01690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AI20_01695	COG1489	DNA binding
AI20_01705	COG1643	Atp-dependent helicase
AI20_01710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AI20_01715	COG0346	lactoylglutathione lyase activity
AI20_01725	COG2076	Multidrug Resistance protein
AI20_01735	COG0784	Response regulator, receiver
AI20_01735	COG3437	response regulator, receiver
AI20_01745	COG0671	phosphoesterase, PA-phosphatase related
AI20_01760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AI20_01765	COG0038	chloride channel
AI20_01775	COG0316	Belongs to the HesB IscA family
AI20_01805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AI20_01825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_01855	COG0745	RESPONSE REGULATOR receiver
AI20_01860	COG3104	oligopeptide transport
AI20_01865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AI20_01870	COG1555	photosystem II stabilization
AI20_01875	COG1218	3'(2'),5'-bisphosphate nucleotidase
AI20_01880	COG2350	Protein conserved in bacteria
AI20_01885	COG2917	probably involved in intracellular septation
AI20_01890	COG0076	glutamate decarboxylase activity
AI20_01895	COG1272	protein, Hemolysin III
AI20_01900	COG2985	domain, Protein
AI20_01900	COG0569	domain protein
AI20_01920	COG0835	chemotaxis
AI20_01920	COG0784	Response regulator, receiver
AI20_01925	COG2755	lipolytic protein G-D-S-L family
AI20_01930	COG4181	ATPase activity
AI20_01935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AI20_01940	COG1090	epimerase
AI20_01945	COG2200	EAL domain
AI20_01950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_01955	COG4935	Belongs to the peptidase S8 family
AI20_01955	COG2234	aminopeptidase activity
AI20_01960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AI20_01965	COG3171	Protein conserved in bacteria
AI20_01970	COG2066	Belongs to the glutaminase family
AI20_01975	COG2897	thiosulfate sulfurtransferase activity
AI20_01980	COG1404	Belongs to the peptidase S8 family
AI20_01990	COG1132	(ABC) transporter
AI20_02015	COG4412	M6 family metalloprotease domain protein
AI20_02015	COG3291	Pkd domain containing protein
AI20_02025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AI20_02030	COG5001	Diguanylate cyclase
AI20_02030	COG3300	MHYT domain
AI20_02055	COG4628	conserved protein (DUF2132)
AI20_02060	COG0688	phosphatidylethanolamine metabolic process
AI20_02065	COG1162	GTPase activity
AI20_02070	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AI20_02105	COG1278	Cold shock
AI20_02115	COG0840	transmembrane signaling receptor activity
AI20_02120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_02180	COG0848	biopolymer transport protein
AI20_02185	COG0811	peptide transport
AI20_02190	COG0811	peptide transport
AI20_02205	COG4174	ABC transporter (Permease)
AI20_02210	COG4239	(ABC) transporter, permease
AI20_02220	COG0444	Belongs to the ABC transporter superfamily
AI20_02225	COG4608	Belongs to the ABC transporter superfamily
AI20_02235	COG2195	Cleaves the N-terminal amino acid of tripeptides
AI20_02240	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AI20_02260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AI20_02290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_02295	COG2313	pseudouridylate synthase activity
AI20_02300	COG3338	carbonate dehydratase activity
AI20_02305	COG1858	cytochrome C peroxidase
AI20_02340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_02345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_02360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_02370	COG2986	histidine ammonia-lyase
AI20_02400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_02410	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_02415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_02425	COG0521	Mo-molybdopterin cofactor biosynthetic process
AI20_02435	COG2966	Psort location CytoplasmicMembrane, score
AI20_02440	COG3610	response to peptide
AI20_02460	COG4175	Glycine betaine
AI20_02465	COG4176	ABC-type proline glycine betaine transport system permease component
AI20_02470	COG2113	Glycine betaine
AI20_02475	COG0175	sulfate reduction
AI20_02480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AI20_02485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AI20_02495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AI20_02500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AI20_02510	COG0786	glutamate:sodium symporter activity
AI20_02515	COG0252	asparaginase activity
AI20_02520	COG3139	Protein of unknown function (DUF1315)
AI20_02540	COG0616	signal peptide processing
AI20_02545	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_02545	COG1902	pentaerythritol trinitrate reductase activity
AI20_02560	COG0778	Nitroreductase
AI20_02570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_02575	COG2264	protein methyltransferase activity
AI20_02580	COG0604	alcohol dehydrogenase
AI20_02585	COG0583	DNA-binding transcription factor activity
AI20_02590	COG1263	PTS System
AI20_02590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_02590	COG2190	(PTS) system
AI20_02595	COG4145	pantothenate transmembrane transporter activity
AI20_02600	COG3924	membrane
AI20_02605	COG0439	Biotin carboxylase
AI20_02610	COG0511	ligase activity, forming carbon-carbon bonds
AI20_02615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AI20_02620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AI20_02630	COG3300	MHYT domain
AI20_02630	COG5001	Diguanylate cyclase
AI20_02650	COG3381	protein complex oligomerization
AI20_02660	COG3005	denitrification pathway
AI20_02665	COG0745	RESPONSE REGULATOR receiver
AI20_02675	COG1879	ABC-type sugar transport system periplasmic component
AI20_02680	COG2205	protein histidine kinase activity
AI20_02680	COG2198	Histidine kinase
AI20_02680	COG0784	Response regulator, receiver
AI20_02690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AI20_02705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AI20_02710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AI20_02710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AI20_02725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AI20_02730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_02735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AI20_02740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AI20_02745	COG4172	Belongs to the ABC transporter superfamily
AI20_02765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AI20_02770	COG0142	geranyltranstransferase activity
AI20_02775	COG1722	exodeoxyribonuclease VII activity
AI20_02780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_02785	COG1360	Flagellar Motor Protein
AI20_02790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AI20_02800	COG1534	Rna-binding protein
AI20_02805	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AI20_02810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AI20_02815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AI20_02820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AI20_02825	COG0149	triose-phosphate isomerase activity
AI20_02830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AI20_02845	COG0779	Required for maturation of 30S ribosomal subunits
AI20_02850	COG0195	Participates in both transcription termination and antitermination
AI20_02855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AI20_02860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AI20_02865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AI20_02870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AI20_02875	COG1185	polyribonucleotide nucleotidyltransferase activity
AI20_02890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AI20_02900	COG0114	fumarate hydratase activity
AI20_02970	COG0312	modulator of DNA gyrase
AI20_02980	COG0312	modulator of DNA gyrase
AI20_02985	COG0716	FMN binding
AI20_02990	COG4974	Belongs to the 'phage' integrase family
AI20_02995	COG2203	Gaf domain
AI20_02995	COG2199	diguanylate cyclase activity
AI20_03000	COG1970	mechanosensitive ion channel activity
AI20_03010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AI20_03015	COG0789	Transcriptional regulator
AI20_03035	COG3545	Serine hydrolase
AI20_03040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AI20_03045	COG0321	lipoyl(octanoyl) transferase activity
AI20_03050	COG2921	Belongs to the UPF0250 family
AI20_03055	COG1686	Belongs to the peptidase S11 family
AI20_03060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AI20_03065	COG2951	lytic endotransglycosylase activity
AI20_03070	COG0772	Belongs to the SEDS family
AI20_03075	COG0768	penicillin binding
AI20_03080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AI20_03085	COG0799	negative regulation of ribosome biogenesis
AI20_03090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AI20_03105	COG0495	leucyl-tRNA aminoacylation
AI20_03110	COG2888	peptidyl-tyrosine sulfation
AI20_03115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AI20_03120	COG4535	Mg2 and Co2 transporter CorC
AI20_03125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AI20_03130	COG1702	phosphate starvation-inducible protein PhoH
AI20_03135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AI20_03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_03145	COG1335	isochorismatase
AI20_03155	COG3706	GGDEF domain
AI20_03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_03180	COG3706	GGDEF domain
AI20_03190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_03200	COG3647	Membrane
AI20_03205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AI20_03215	COG0516	GMP reductase activity
AI20_03225	COG0642	Histidine kinase
AI20_03230	COG0745	RESPONSE REGULATOR receiver
AI20_03260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AI20_03265	COG3214	Protein conserved in bacteria
AI20_03290	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AI20_03295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AI20_03300	COG1053	succinate dehydrogenase
AI20_03310	COG0584	glycerophosphoryl diester phosphodiesterase
AI20_03315	COG3264	Mechanosensitive ion channel
AI20_03315	COG1511	domain protein
AI20_03325	COG0739	heme binding
AI20_03340	COG0583	DNA-binding transcription factor activity
AI20_03360	COG0583	DNA-binding transcription factor activity
AI20_03365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AI20_03395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AI20_03400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AI20_03410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AI20_03415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AI20_03420	COG0546	phosphoglycolate phosphatase activity
AI20_03425	COG0180	Tryptophanyl-tRNA synthetase
AI20_03440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AI20_03450	COG1012	belongs to the aldehyde dehydrogenase family
AI20_03460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_03470	COG0674	pyruvate-flavodoxin oxidoreductase activity
AI20_03470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_03470	COG1013	pyruvate-flavodoxin oxidoreductase activity
AI20_03470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AI20_03500	COG0488	(ABC) transporter
AI20_03515	COG0366	Alpha amylase catalytic
AI20_03535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AI20_03545	COG0471	metal ion transport
AI20_03545	COG0490	domain, Protein
AI20_03590	COG0012	GTP binding
AI20_03595	COG0193	aminoacyl-tRNA hydrolase activity
AI20_03600	COG0737	Belongs to the 5'-nucleotidase family
AI20_03605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AI20_03620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AI20_03625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AI20_03630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AI20_03635	COG2890	protein-(glutamine-N5) methyltransferase activity
AI20_03645	COG2912	Transglutaminase-like superfamily
AI20_03650	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AI20_03655	COG1301	dicarboxylic acid transport
AI20_03665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AI20_03680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AI20_03685	COG1115	amino acid carrier protein
AI20_03700	COG0714	Associated with various cellular activities
AI20_03710	COG3104	oligopeptide transport
AI20_03715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AI20_03720	COG1678	Uncharacterized ACR, COG1678
AI20_03730	COG0189	ligase activity
AI20_03735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AI20_03745	COG3091	SprT-like family
AI20_03755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AI20_03775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AI20_03785	COG0739	heme binding
AI20_03790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AI20_03795	COG3408	Glycogen debranching enzyme
AI20_03795	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AI20_03805	COG1881	PFAM PEBP family protein
AI20_03815	COG0583	DNA-binding transcription factor activity
AI20_03825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AI20_03835	COG0583	DNA-binding transcription factor activity
AI20_03840	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_03845	COG0616	signal peptide processing
AI20_03850	COG3724	N-succinylarginine dihydrolase activity
AI20_03855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AI20_03870	COG0840	transmembrane signaling receptor activity
AI20_03880	COG2971	BadF BadG BcrA BcrD
AI20_03890	COG4608	Belongs to the ABC transporter superfamily
AI20_03895	COG0444	Belongs to the ABC transporter superfamily
AI20_03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_03905	COG0601	transmembrane transport
AI20_03910	COG4166	transmembrane transport
AI20_03955	COG3220	belongs to the UPF0276 family
AI20_03985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_03990	COG1289	transmembrane transporter activity
AI20_03995	COG0303	'Molybdopterin
AI20_04000	COG0746	molybdenum cofactor guanylyltransferase activity
AI20_04010	COG4662	Binding-protein-dependent transport system inner membrane component
AI20_04025	COG3852	Histidine kinase
AI20_04030	COG1910	domain protein
AI20_04035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AI20_04065	COG3383	formate dehydrogenase (NAD+) activity
AI20_04065	COG3383	formate dehydrogenase (NAD+) activity
AI20_04070	COG0437	4 iron, 4 sulfur cluster binding
AI20_04080	COG0281	malic enzyme
AI20_04100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_04115	COG2706	6-phosphogluconolactonase activity
AI20_04125	COG3264	Mechanosensitive ion channel
AI20_04125	COG1196	nuclear chromosome segregation
AI20_04130	COG0469	pyruvate kinase activity
AI20_04145	COG4651	solute:proton antiporter activity
AI20_04145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AI20_04155	COG2974	May be involved in recombination
AI20_04165	COG0420	3'-5' exonuclease activity
AI20_04170	COG0419	ATPase involved in DNA repair
AI20_04180	COG3038	cytochrome b561
AI20_04185	COG0745	RESPONSE REGULATOR receiver
AI20_04185	COG3706	GGDEF domain
AI20_04190	COG2190	(PTS) system
AI20_04195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AI20_04200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_04205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AI20_04210	COG0542	response to heat
AI20_04225	COG2770	Histidine kinase
AI20_04225	COG3437	response regulator, receiver
AI20_04230	COG1720	tRNA m6t6A37 methyltransferase activity
AI20_04250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AI20_04255	COG4988	ABC transporter
AI20_04270	COG0745	RESPONSE REGULATOR receiver
AI20_04280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AI20_04295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AI20_04300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AI20_04310	COG0083	homoserine kinase activity
AI20_04315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AI20_04320	COG4319	ketosteroid isomerase
AI20_04335	COG0488	(ABC) transporter
AI20_04350	COG0813	purine-nucleoside phosphorylase activity
AI20_04365	COG2205	protein histidine kinase activity
AI20_04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_04370	COG3706	GGDEF domain
AI20_04370	COG4251	negative regulation of phosphorylation
AI20_04370	COG2203	Gaf domain
AI20_04370	COG5001	Diguanylate cyclase
AI20_04375	COG5002	protein histidine kinase activity
AI20_04375	COG2205	protein histidine kinase activity
AI20_04375	COG0784	Response regulator, receiver
AI20_04380	COG3384	dioxygenase
AI20_04390	COG1283	sodium-dependent phosphate transmembrane transporter activity
AI20_04400	COG0531	amino acid
AI20_04410	COG0531	amino acid
AI20_04430	COG1917	Cupin 2, conserved barrel domain protein
AI20_04430	COG1396	sequence-specific DNA binding
AI20_04435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_04455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_04460	COG2375	cellular response to nickel ion
AI20_04465	COG1538	Outer membrane efflux protein
AI20_04470	COG0577	efflux transmembrane transporter activity
AI20_04470	COG1136	(ABC) transporter
AI20_04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_04485	COG1227	inorganic diphosphatase activity
AI20_04490	COG0497	DNA recombination
AI20_04495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AI20_04500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AI20_04505	COG0443	Heat shock 70 kDa protein
AI20_04510	COG0484	heat shock protein binding
AI20_04540	COG1285	pathogenesis
AI20_04555	COG0640	Transcriptional regulator
AI20_04585	COG0095	Lipoate-protein ligase
AI20_04600	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_04605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_04630	COG0708	Exodeoxyribonuclease III
AI20_04645	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_04650	COG2211	Major facilitator Superfamily
AI20_04690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AI20_04695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AI20_04700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AI20_04705	COG1845	cytochrome c oxidase, subunit III
AI20_04710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AI20_04715	COG0109	protoheme IX farnesyltransferase activity
AI20_04720	COG2814	Major facilitator Superfamily
AI20_04730	COG2175	clavaminate synthase activity
AI20_04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AI20_04740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AI20_04745	COG4521	taurine ABC transporter
AI20_04755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_04775	COG1988	membrane-bound metal-dependent
AI20_04810	COG0159	tryptophan synthase activity
AI20_04815	COG0133	tryptophan synthase activity
AI20_04820	COG0135	phosphoribosylanthranilate isomerase activity
AI20_04820	COG0134	indole-3-glycerol-phosphate synthase activity
AI20_04825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AI20_04830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AI20_04830	COG0512	Glutamine amidotransferase of anthranilate synthase
AI20_04835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AI20_04845	COG0009	L-threonylcarbamoyladenylate synthase
AI20_04855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AI20_04865	COG1946	Acyl-CoA thioesterase
AI20_04880	COG1309	transcriptional regulator
AI20_04885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_04890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_04895	COG1538	Outer membrane efflux protein
AI20_04905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AI20_04960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AI20_04980	COG3132	Protein of unknown function, DUF480
AI20_05020	COG1278	Cold shock
AI20_05045	COG4166	transmembrane transport
AI20_05050	COG0697	spore germination
AI20_05055	COG1349	DNA-binding transcription factor activity
AI20_05065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_05070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AI20_05085	COG1187	pseudouridine synthase activity
AI20_05095	COG4166	transmembrane transport
AI20_05100	COG0622	Phosphoesterase
AI20_05115	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AI20_05120	COG0784	Response regulator, receiver
AI20_05120	COG0835	chemotaxis
AI20_05125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AI20_05130	COG1815	bacterial-type flagellum-dependent cell motility
AI20_05135	COG1558	bacterial-type flagellum-dependent cell motility
AI20_05150	COG4787	bacterial-type flagellum-dependent cell motility
AI20_05155	COG4786	Flagellar basal body rod
AI20_05160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AI20_05165	COG1706	bacterial-type flagellum-dependent cell motility
AI20_05170	COG1705	Flagellar rod assembly protein muramidase FlgJ
AI20_05170	COG3951	Flagellar rod assembly protein muramidase FlgJ
AI20_05175	COG1256	bacterial-type flagellum assembly
AI20_05185	COG2239	Acts as a magnesium transporter
AI20_05190	COG0248	Ppx GppA phosphatase
AI20_05195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AI20_05200	COG2716	regulation of RNA biosynthetic process
AI20_05210	COG2204	response regulator
AI20_05215	COG3852	Histidine kinase
AI20_05220	COG2204	response regulator
AI20_05225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AI20_05230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AI20_05235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AI20_05240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AI20_05260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AI20_05280	COG0590	tRNA wobble adenosine to inosine editing
AI20_05285	COG0573	inorganic phosphate transmembrane transporter activity
AI20_05290	COG0581	inorganic phosphate transmembrane transporter activity
AI20_05300	COG0704	Plays a role in the regulation of phosphate uptake
AI20_05320	COG1253	flavin adenine dinucleotide binding
AI20_05335	COG0531	amino acid
AI20_05360	COG0765	amino acid transport
AI20_05365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_05370	COG2271	Major facilitator Superfamily
AI20_05385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AI20_05415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AI20_05420	COG0477	Major facilitator Superfamily
AI20_05425	COG0123	including yeast histone deacetylase and acetoin utilization protein
AI20_05435	COG1199	ATP-dependent helicase activity
AI20_05450	COG1448	Aminotransferase
AI20_05455	COG0433	COG0433 Predicted ATPase
AI20_05470	COG0658	competence protein
AI20_05470	COG2333	competence protein COMEC
AI20_05480	COG1663	tetraacyldisaccharide 4'-kinase activity
AI20_05485	COG2835	tetraacyldisaccharide 4'-kinase activity
AI20_05490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AI20_05495	COG2197	response regulator
AI20_05500	COG0322	excinuclease ABC activity
AI20_05525	COG4974	Belongs to the 'phage' integrase family
AI20_05565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_05640	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AI20_05645	COG0437	4 iron, 4 sulfur cluster binding
AI20_05650	COG3301	Polysulphide reductase, NrfD
AI20_05655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_05665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AI20_05670	COG0215	cysteine-tRNA ligase activity
AI20_05685	COG2199	diguanylate cyclase activity
AI20_05685	COG2203	Gaf domain
AI20_05715	COG2119	membrane
AI20_05720	COG0023	Translation Initiation Factor
AI20_05760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_05760	COG2205	protein histidine kinase activity
AI20_05770	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AI20_05775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_05780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AI20_05785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AI20_05790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AI20_05795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AI20_05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AI20_05810	COG0505	Belongs to the CarA family
AI20_05815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AI20_05820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AI20_05860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_05865	COG0513	Belongs to the DEAD box helicase family
AI20_05875	COG4104	PAAR repeat-containing protein
AI20_05890	COG0789	Transcriptional regulator
AI20_05905	COG0493	'glutamate synthase
AI20_05910	COG0069	glutamate synthase activity
AI20_05910	COG0067	glutamate synthase
AI20_05910	COG0070	glutamate synthase
AI20_05915	COG1242	4 iron, 4 sulfur cluster binding
AI20_05980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AI20_05985	COG0574	Belongs to the PEP-utilizing enzyme family
AI20_05985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AI20_06030	COG1464	Belongs to the NlpA lipoprotein family
AI20_06035	COG0671	phosphoesterase, PA-phosphatase related
AI20_06040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AI20_06045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AI20_06055	COG0101	tRNA pseudouridine synthase activity
AI20_06060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AI20_06065	COG0285	dihydrofolate synthase activity
AI20_06070	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AI20_06075	COG2920	part of a sulfur-relay system
AI20_06080	COG1289	transmembrane transporter activity
AI20_06085	COG0670	Belongs to the BI1 family
AI20_06105	COG2194	sulfuric ester hydrolase activity
AI20_06110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AI20_06110	COG0392	lysyltransferase activity
AI20_06120	COG0840	transmembrane signaling receptor activity
AI20_06125	COG5001	Diguanylate cyclase
AI20_06130	COG0564	pseudouridine synthase activity
AI20_06145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AI20_06155	COG0625	glutathione transferase activity
AI20_06165	COG0367	asparagine synthase
AI20_06175	COG4651	solute:proton antiporter activity
AI20_06175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AI20_06180	COG0647	UMP catabolic process
AI20_06185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AI20_06190	COG1902	pentaerythritol trinitrate reductase activity
AI20_06195	COG1253	flavin adenine dinucleotide binding
AI20_06205	COG0277	FAD linked oxidase domain protein
AI20_06205	COG0247	lactate metabolic process
AI20_06215	COG2050	protein possibly involved in aromatic compounds catabolism
AI20_06230	COG2056	Na+-H+ antiporter family
AI20_06235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AI20_06245	COG2885	chlorophyll binding
AI20_06250	COG0346	lactoylglutathione lyase activity
AI20_06255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AI20_06265	COG4659	FMN binding
AI20_06270	COG4658	electron transport chain
AI20_06280	COG2878	Part of a membrane complex involved in electron transport
AI20_06285	COG4657	Part of a membrane complex involved in electron transport
AI20_06290	COG0697	spore germination
AI20_06305	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AI20_06310	COG1288	antiporter activity
AI20_06315	COG3264	Mechanosensitive ion channel
AI20_06315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AI20_06320	COG0436	Aminotransferase
AI20_06330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AI20_06335	COG2027	D-alanyl-D-alanine carboxypeptidase
AI20_06340	COG1061	Type III restriction enzyme res subunit
AI20_06345	COG1566	PFAM secretion protein HlyD family protein
AI20_06355	COG1966	Carbon starvation protein
AI20_06360	COG3279	Response regulator of the LytR AlgR family
AI20_06365	COG3275	phosphorelay sensor kinase activity
AI20_06370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_06370	COG2199	diguanylate cyclase activity
AI20_06375	COG1012	belongs to the aldehyde dehydrogenase family
AI20_06375	COG1454	alcohol dehydrogenase
AI20_06385	COG2095	MarC family integral membrane protein
AI20_06395	COG0601	transmembrane transport
AI20_06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_06405	COG0444	Belongs to the ABC transporter superfamily
AI20_06415	COG0861	Integral membrane protein TerC family
AI20_06420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_06430	COG1301	dicarboxylic acid transport
AI20_06445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AI20_06460	COG0537	adenosine 5'-monophosphoramidase activity
AI20_06495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_06500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_06515	COG2354	Protein conserved in bacteria
AI20_06530	COG2233	PERMEase
AI20_06540	COG1252	NADH dehydrogenase
AI20_06565	COG0393	Putative heavy-metal-binding
AI20_06575	COG1619	proteins homologs of microcin C7 resistance protein MccF
AI20_06580	COG1368	sulfuric ester hydrolase activity
AI20_06590	COG0527	aspartate kinase activity
AI20_06595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AI20_06595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AI20_06600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AI20_06620	COG0596	Alpha beta hydrolase
AI20_06625	COG0583	DNA-binding transcription factor activity
AI20_06630	COG1620	l-lactate permease
AI20_06635	COG0247	lactate metabolic process
AI20_06640	COG1139	Iron-sulfur cluster binding protein
AI20_06665	COG1136	(ABC) transporter
AI20_06685	COG2814	Major facilitator Superfamily
AI20_06710	COG0672	)-iron permease
AI20_06750	COG0659	secondary active sulfate transmembrane transporter activity
AI20_06770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_06775	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AI20_06780	COG0437	4 iron, 4 sulfur cluster binding
AI20_06785	COG5557	Pfam Polysulphide reductase, NrfD
AI20_06790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AI20_06795	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AI20_06800	COG1773	rubredoxin
AI20_06805	COG0747	negative chemotaxis
AI20_06815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_06820	COG0444	Belongs to the ABC transporter superfamily
AI20_06825	COG3842	ATPase activity
AI20_06830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AI20_06840	COG0375	protein maturation
AI20_06845	COG0309	Hydrogenase expression formation protein (HypE)
AI20_06855	COG0298	carbon dioxide binding
AI20_06860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AI20_06870	COG1921	L-seryl-tRNASec selenium transferase activity
AI20_06875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AI20_06885	COG3260	NADH ubiquinone oxidoreductase 20
AI20_06890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_06895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AI20_06895	COG3261	NADH dehydrogenase
AI20_06900	COG0650	Formate hydrogenlyase subunit 4
AI20_06905	COG0651	ATP synthesis coupled electron transport
AI20_06910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_06915	COG3158	transport of potassium into the cell
AI20_06925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_06930	COG3383	formate dehydrogenase (NAD+) activity
AI20_06935	COG3383	formate dehydrogenase (NAD+) activity
AI20_06955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AI20_06960	COG0326	Molecular chaperone. Has ATPase activity
AI20_06965	COG0563	adenylate kinase activity
AI20_06970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AI20_06975	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AI20_06980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_06995	COG5001	Diguanylate cyclase
AI20_06995	COG3300	MHYT domain
AI20_07000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AI20_07020	COG1021	2,3-dihydroxybenzoate-AMP ligase
AI20_07025	COG1535	isochorismatase
AI20_07025	COG3433	isochorismatase activity
AI20_07030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_07035	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_07045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_07050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AI20_07055	COG2977	Belongs to the P-Pant transferase superfamily
AI20_07060	COG1120	ATPase activity
AI20_07065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_07070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_07075	COG4771	TonB-dependent receptor
AI20_07095	COG0598	Magnesium transport protein CorA
AI20_07120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AI20_07125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AI20_07130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_07145	COG1570	exodeoxyribonuclease VII activity
AI20_07150	COG0697	spore germination
AI20_07170	COG3158	transport of potassium into the cell
AI20_07175	COG0516	GMP reductase activity
AI20_07175	COG0517	IMP dehydrogenase activity
AI20_07180	COG0519	Catalyzes the synthesis of GMP from XMP
AI20_07180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AI20_07220	COG2062	phosphohistidine phosphatase, SixA
AI20_07230	COG0697	spore germination
AI20_07235	COG4166	transmembrane transport
AI20_07240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AI20_07245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AI20_07255	COG4591	ABC-type transport system involved in lipoprotein release permease component
AI20_07260	COG1136	(ABC) transporter
AI20_07265	COG4591	ABC-type transport system involved in lipoprotein release permease component
AI20_07270	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AI20_07285	COG0544	peptidyl-prolyl cis-trans isomerase activity
AI20_07290	COG0740	serine-type endopeptidase activity
AI20_07295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AI20_07300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AI20_07305	COG0776	regulation of translation
AI20_07310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AI20_07315	COG0488	(ABC) transporter
AI20_07320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AI20_07325	COG3162	membrane
AI20_07340	COG1024	Enoyl-CoA hydratase
AI20_07345	COG1115	amino acid carrier protein
AI20_07360	COG1584	GPR1 FUN34 yaaH family protein
AI20_07395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AI20_07400	COG1960	acyl-CoA dehydrogenase activity
AI20_07410	COG1960	acyl-CoA dehydrogenase activity
AI20_07415	COG1024	Enoyl-CoA hydratase
AI20_07420	COG1024	Enoyl-CoA hydratase
AI20_07430	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_07440	COG0730	response to heat
AI20_07450	COG1073	alpha beta
AI20_07455	COG1073	alpha beta
AI20_07460	COG0702	epimerase
AI20_07465	COG0583	DNA-binding transcription factor activity
AI20_07470	COG0667	Aldo Keto reductase
AI20_07490	COG0583	DNA-binding transcription factor activity
AI20_07495	COG2723	6-phospho-beta-galactosidase activity
AI20_07500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_07510	COG0583	DNA-binding transcription factor activity
AI20_07515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AI20_07520	COG0673	inositol 2-dehydrogenase activity
AI20_07525	COG0583	DNA-binding transcription factor activity
AI20_07535	COG1560	Kdo2-lipid A biosynthetic process
AI20_07540	COG1560	Kdo2-lipid A biosynthetic process
AI20_07555	COG2203	Gaf domain
AI20_07555	COG2199	diguanylate cyclase activity
AI20_07565	COG0417	DNA replication proofreading
AI20_07595	COG0534	Mate efflux family protein
AI20_07605	COG0307	riboflavin synthase, alpha
AI20_07620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_07625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AI20_07630	COG0697	spore germination
AI20_07635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AI20_07685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AI20_07695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AI20_07700	COG2894	cell division
AI20_07705	COG0850	regulation of cytokinetic process
AI20_07710	COG3100	YcgL domain-containing protein
AI20_07715	COG2951	lytic endotransglycosylase activity
AI20_07720	COG1760	l-serine dehydratase
AI20_07725	COG1760	l-serine dehydratase
AI20_07730	COG3123	guanosine phosphorylase activity
AI20_07750	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AI20_07755	COG2067	long-chain fatty acid transport protein
AI20_07770	COG1595	DNA-templated transcription, initiation
AI20_07800	COG0714	Associated with various cellular activities
AI20_07805	COG0183	Belongs to the thiolase family
AI20_07810	COG1024	Enoyl-CoA hydratase
AI20_07810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AI20_07820	COG4681	YaeQ
AI20_07840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AI20_07845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AI20_07850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AI20_07860	COG0549	Belongs to the carbamate kinase family
AI20_07865	COG0697	spore germination
AI20_07870	COG3608	succinylglutamate desuccinylase aspartoacylase
AI20_07870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AI20_07875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AI20_07885	COG0493	'glutamate synthase
AI20_07885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_07890	COG0402	S-adenosylhomocysteine deaminase activity
AI20_07895	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AI20_07900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AI20_07900	COG2080	2 iron, 2 sulfur cluster binding
AI20_07905	COG2233	PERMEase
AI20_07910	COG0402	S-adenosylhomocysteine deaminase activity
AI20_07915	COG2252	PERMEase
AI20_07920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AI20_07925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AI20_07930	COG2080	2 iron, 2 sulfur cluster binding
AI20_07940	COG3134	Outer membrane lipoprotein
AI20_07950	COG1288	antiporter activity
AI20_07955	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_07960	COG2378	regulation of single-species biofilm formation
AI20_07970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AI20_07970	COG0140	phosphoribosyl-ATP diphosphatase activity
AI20_07975	COG0107	imidazoleglycerol-phosphate synthase activity
AI20_07980	COG2205	protein histidine kinase activity
AI20_07980	COG0784	Response regulator, receiver
AI20_07980	COG2198	Histidine kinase
AI20_07990	COG3437	response regulator, receiver
AI20_07995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AI20_08000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AI20_08005	COG0131	Imidazoleglycerol-phosphate dehydratase
AI20_08005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AI20_08010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AI20_08015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AI20_08020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AI20_08030	COG1199	ATP-dependent helicase activity
AI20_08035	COG1214	PFAM Peptidase M22, glycoprotease
AI20_08045	COG1073	alpha beta
AI20_08045	COG2226	methyltransferase
AI20_08050	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_08070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AI20_08075	COG2832	Protein of unknown function (DUF454)
AI20_08080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AI20_08085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AI20_08090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AI20_08095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AI20_08120	COG1643	Atp-dependent helicase
AI20_08140	COG3437	response regulator, receiver
AI20_08145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AI20_08150	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AI20_08155	COG0709	Synthesizes selenophosphate from selenide and ATP
AI20_08170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AI20_08175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AI20_08180	COG0840	transmembrane signaling receptor activity
AI20_08185	COG1254	Belongs to the acylphosphatase family
AI20_08190	COG0625	glutathione transferase activity
AI20_08195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_08195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_08200	COG0489	protein tyrosine kinase activity
AI20_08205	COG0572	uridine kinase
AI20_08210	COG0717	Belongs to the dCTP deaminase family
AI20_08215	COG0306	phosphate transporter
AI20_08220	COG1530	ribonuclease E activity
AI20_08230	COG0546	phosphoglycolate phosphatase activity
AI20_08235	COG0424	maF-like protein
AI20_08245	COG1399	metal-binding, possibly nucleic acid-binding protein
AI20_08255	COG0416	fatty acid biosynthetic process
AI20_08260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AI20_08270	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_08275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_08280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_08285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AI20_08290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AI20_08295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AI20_08300	COG0470	DNA polymerase III
AI20_08305	COG0084	hydrolase, TatD family'
AI20_08320	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AI20_08320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_08325	COG3008	intermembrane lipid transfer
AI20_08330	COG2995	paraquat-inducible protein a
AI20_08340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AI20_08345	COG0372	Belongs to the citrate synthase family
AI20_08390	COG4221	oxidoreductase activity
AI20_08400	COG3141	response to X-ray
AI20_08410	COG1067	ATP-dependent peptidase activity
AI20_08415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_08430	COG0488	(ABC) transporter
AI20_08440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AI20_08440	COG0116	Belongs to the methyltransferase superfamily
AI20_08455	COG0167	dihydroorotate dehydrogenase activity
AI20_08460	COG2902	Dehydrogenase
AI20_08470	COG0308	aminopeptidase N
AI20_08480	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AI20_08485	COG1956	GAF domain-containing protein
AI20_08495	COG3278	Belongs to the heme-copper respiratory oxidase family
AI20_08510	COG2010	Cytochrome c
AI20_08535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AI20_08540	COG0589	response to stress
AI20_08545	COG0037	tRNA processing
AI20_08565	COG1869	D-ribose catabolic process
AI20_08570	COG1129	ABC transporter
AI20_08575	COG1172	Belongs to the binding-protein-dependent transport system permease family
AI20_08580	COG1879	ABC-type sugar transport system periplasmic component
AI20_08585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_08590	COG1609	Transcriptional regulator
AI20_08595	COG3300	MHYT domain
AI20_08595	COG5001	Diguanylate cyclase
AI20_08605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AI20_08620	COG0784	Response regulator, receiver
AI20_08620	COG2205	protein histidine kinase activity
AI20_08625	COG0776	regulation of translation
AI20_08630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_08630	COG0072	phenylalanine-tRNA ligase activity
AI20_08635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AI20_08640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AI20_08645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AI20_08650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AI20_08655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AI20_08680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AI20_08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AI20_08695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AI20_08700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_08705	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AI20_08710	COG3313	Fe-S protein
AI20_08715	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AI20_08715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_08715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_08720	COG1105	Belongs to the carbohydrate kinase PfkB family
AI20_08725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_08725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_08730	COG1609	Transcriptional regulator
AI20_08735	COG0814	amino acid
AI20_08745	COG0583	DNA-binding transcription factor activity
AI20_08750	COG0513	Belongs to the DEAD box helicase family
AI20_08760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AI20_08765	COG2890	protein-(glutamine-N5) methyltransferase activity
AI20_08770	COG2840	Smr protein MutS2
AI20_08780	COG3706	GGDEF domain
AI20_08810	COG2824	Alkylphosphonate utilization operon protein PhnA
AI20_08830	COG0384	phenazine biosynthesis protein PhzF
AI20_08855	COG0242	peptide deformylase activity
AI20_08870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AI20_08875	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AI20_08880	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AI20_08890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AI20_08895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AI20_08905	COG0205	6-phosphofructokinase activity
AI20_08910	COG1473	amidohydrolase
AI20_08915	COG1011	Hydrolase
AI20_08920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_08975	COG3593	DNA synthesis involved in DNA repair
AI20_08990	COG0583	DNA-binding transcription factor activity
AI20_08995	COG0730	response to heat
AI20_09010	COG1181	Belongs to the D-alanine--D-alanine ligase family
AI20_09025	COG0386	Belongs to the glutathione peroxidase family
AI20_09030	COG0513	Belongs to the DEAD box helicase family
AI20_09070	COG2329	Antibiotic biosynthesis monooxygenase
AI20_09075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AI20_09110	COG2501	S4 domain
AI20_09120	COG1132	(ABC) transporter
AI20_09125	COG1132	(ABC) transporter
AI20_09135	COG3118	belongs to the thioredoxin family
AI20_09140	COG0471	metal ion transport
AI20_09145	COG0058	SHG alpha-glucan phosphorylase activity
AI20_09175	COG0814	amino acid
AI20_09180	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AI20_09185	COG0514	ATP-dependent DNA helicase (RecQ)
AI20_09190	COG2766	serine protein kinase
AI20_09195	COG2718	Belongs to the UPF0229 family
AI20_09200	COG2719	SpoVR family
AI20_09205	COG2186	Transcriptional regulator
AI20_09210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_09215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AI20_09220	COG0586	Pfam SNARE associated Golgi protein
AI20_09230	COG0556	nucleotide-excision repair
AI20_09240	COG2985	domain, Protein
AI20_09240	COG0569	domain protein
AI20_09245	COG0739	heme binding
AI20_09245	COG1196	nuclear chromosome segregation
AI20_09245	COG0741	lytic transglycosylase activity
AI20_09265	COG4565	transcriptional regulatory protein
AI20_09270	COG3290	protein histidine kinase activity
AI20_09275	COG1846	Transcriptional regulator
AI20_09275	COG1940	carbohydrate kinase activity
AI20_09280	COG0840	transmembrane signaling receptor activity
AI20_09285	COG3012	SEC-C Motif Domain Protein
AI20_09290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AI20_09295	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AI20_09300	COG0247	lactate metabolic process
AI20_09315	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AI20_09320	COG0437	4 iron, 4 sulfur cluster binding
AI20_09325	COG3301	Polysulphide reductase, NrfD
AI20_09335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_09355	COG3033	Beta-eliminating lyase
AI20_09360	COG3046	protein related to deoxyribodipyrimidine photolyase
AI20_09365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_09385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AI20_09390	COG0583	DNA-binding transcription factor activity
AI20_09400	COG4774	siderophore transport
AI20_09405	COG4977	sequence-specific DNA binding
AI20_09415	COG0583	DNA-binding transcription factor activity
AI20_09420	COG2910	NAD(P)H-binding
AI20_09430	COG0626	cystathionine gamma-synthase activity
AI20_09435	COG0612	Peptidase, M16
AI20_09440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AI20_09445	COG2076	Multidrug Resistance protein
AI20_09450	COG1944	ATP diphosphatase activity
AI20_09455	COG2116	formate transmembrane transporter activity
AI20_09460	COG1882	Formate acetyltransferase
AI20_09465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_09475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AI20_09485	COG1840	ABC-type Fe3 transport system, periplasmic component
AI20_09490	COG3842	ATPase activity
AI20_09500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_09505	COG2983	Belongs to the UPF0260 family
AI20_09520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AI20_09525	COG0045	succinate-CoA ligase (ADP-forming) activity
AI20_09530	COG0508	dehydrogenase complex catalyzes the overall conversion of
AI20_09535	COG0567	Dehydrogenase, E1 component
AI20_09550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AI20_09555	COG2009	succinate dehydrogenase
AI20_09575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_09580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AI20_09580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_09590	COG3069	C4-dicarboxylate transmembrane transporter activity
AI20_09605	COG1451	nucleotide metabolic process
AI20_09620	COG0254	rRNA binding
AI20_09625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AI20_09635	COG0583	DNA-binding transcription factor activity
AI20_09640	COG2925	Exonuclease
AI20_09650	COG3345	alpha-galactosidase
AI20_09655	COG1380	Effector of murein hydrolase LrgA
AI20_09660	COG1346	cytolysis
AI20_09665	COG0295	cytidine deaminase activity
AI20_09670	COG1022	Amp-dependent synthetase and ligase
AI20_09685	COG0861	Integral membrane protein TerC family
AI20_09690	COG2885	chlorophyll binding
AI20_09710	COG2154	pterin-4-alpha-carbinolamine dehydratase
AI20_09720	COG3768	UPF0283 membrane protein
AI20_09725	COG3106	COG3106 Predicted ATPase
AI20_09740	COG1842	Phage shock protein A
AI20_09745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AI20_09755	COG4168	peptide transport system, permease
AI20_09760	COG4171	peptide transport system, permease
AI20_09770	COG4172	Belongs to the ABC transporter superfamily
AI20_09780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AI20_09785	COG1286	toxin biosynthetic process
AI20_09790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AI20_09795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AI20_09800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AI20_09805	COG0531	amino acid
AI20_09805	COG1674	ftsk spoiiie
AI20_09815	COG0492	ferredoxin-NADP+ reductase activity
AI20_09820	COG3706	GGDEF domain
AI20_09825	COG3134	Outer membrane lipoprotein
AI20_09830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AI20_09835	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AI20_09840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AI20_09845	COG0542	response to heat
AI20_09850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AI20_09855	COG1278	Cold shock
AI20_09860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AI20_09890	COG3501	Rhs element vgr protein
AI20_09900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AI20_09935	COG1435	thymidine kinase activity
AI20_09940	COG1757	Na H antiporter
AI20_09945	COG2916	Histone family protein nucleoid-structuring protein H-NS
AI20_09950	COG2096	Adenosyltransferase
AI20_09955	COG3530	Putative quorum-sensing-regulated virulence factor
AI20_09960	COG0602	queuosine metabolic process
AI20_09965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AI20_09985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AI20_09995	COG0776	regulation of translation
AI20_10000	COG0539	negative regulation of cytoplasmic translation
AI20_10005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AI20_10010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AI20_10020	COG0583	DNA-binding transcription factor activity
AI20_10040	COG0778	Nitroreductase
AI20_10045	COG3300	MHYT domain
AI20_10045	COG5001	Diguanylate cyclase
AI20_10055	COG0583	DNA-binding transcription factor activity
AI20_10060	COG3437	response regulator, receiver
AI20_10085	COG4989	oxidoreductase activity
AI20_10090	COG0724	RNA recognition motif
AI20_10110	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AI20_10125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_10130	COG1360	Flagellar Motor Protein
AI20_10135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_10140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_10145	COG0649	NAD binding
AI20_10145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_10160	COG1034	ATP synthesis coupled electron transport
AI20_10165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AI20_10170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_10175	COG0839	Belongs to the complex I subunit 6 family
AI20_10180	COG0713	ATP synthesis coupled electron transport
AI20_10190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_10195	COG1007	ATP synthesis coupled electron transport
AI20_10210	COG2199	diguanylate cyclase activity
AI20_10210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_10215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AI20_10215	COG0047	phosphoribosylformylglycinamidine synthase activity
AI20_10220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AI20_10230	COG1645	bacterial-type flagellum-dependent swarming motility
AI20_10235	COG1160	GTP binding
AI20_10240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_10245	COG2976	Protein conserved in bacteria
AI20_10250	COG0124	histidyl-tRNA synthetase
AI20_10255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AI20_10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AI20_10275	COG0105	UTP biosynthetic process
AI20_10280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_10290	COG0633	Ferredoxin
AI20_10295	COG0443	Heat shock 70 kDa protein
AI20_10300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AI20_10310	COG0822	iron-sulfur transferase activity
AI20_10315	COG1104	cysteine desulfurase activity
AI20_10360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_10365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_10370	COG1862	Preprotein translocase
AI20_10375	COG0343	queuine tRNA-ribosyltransferase activity
AI20_10380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AI20_10385	COG0517	IMP dehydrogenase activity
AI20_10390	COG0450	alkyl hydroperoxide reductase
AI20_10395	COG3634	alkyl hydroperoxide reductase activity
AI20_10400	COG0477	Major facilitator Superfamily
AI20_10405	COG3852	Histidine kinase
AI20_10420	COG3119	arylsulfatase activity
AI20_10425	COG0641	radical SAM
AI20_10430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AI20_10430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AI20_10435	COG0509	glycine decarboxylation via glycine cleavage system
AI20_10440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AI20_10445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_10450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_10470	COG2814	Major facilitator Superfamily
AI20_10475	COG0625	glutathione transferase activity
AI20_10485	COG0483	inositol monophosphate 1-phosphatase activity
AI20_10505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AI20_10515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AI20_10545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AI20_10565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_10565	COG0301	tRNA thio-modification
AI20_10575	COG4953	penicillin-binding protein 1C
AI20_10580	COG2373	Large extracellular alpha-helical protein
AI20_10585	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_10595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_10630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AI20_10640	COG1216	Glycosyl transferase, family 2
AI20_10660	COG4215	(ABC) transporter
AI20_10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_10675	COG2431	L-lysine efflux transmembrane transporter activity
AI20_10680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_10700	COG1393	Belongs to the ArsC family
AI20_10710	COG4783	chaperone-mediated protein folding
AI20_10715	COG0425	Belongs to the sulfur carrier protein TusA family
AI20_10740	COG3842	ATPase activity
AI20_10750	COG1175	transmembrane transport
AI20_10760	COG3081	Nucleoid-associated protein
AI20_10765	COG3082	Protein of unknown function (DUF1414)
AI20_10770	COG3083	sulfuric ester hydrolase activity
AI20_10775	COG4771	TonB-dependent receptor
AI20_10780	COG1770	oligopeptidase
AI20_10800	COG4574	serine-type endopeptidase inhibitor activity
AI20_10805	COG3085	chromosome segregation
AI20_10810	COG0583	DNA-binding transcription factor activity
AI20_10815	COG0287	Prephenate dehydrogenase
AI20_10815	COG1605	Chorismate mutase
AI20_10820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_10825	COG0584	glycerophosphoryl diester phosphodiesterase
AI20_10840	COG1349	DNA-binding transcription factor activity
AI20_10845	COG2271	Major facilitator Superfamily
AI20_10850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AI20_10855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AI20_10860	COG0840	transmembrane signaling receptor activity
AI20_10870	COG0583	DNA-binding transcription factor activity
AI20_10895	COG0656	L-ascorbic acid biosynthetic process
AI20_10900	COG2814	Major facilitator Superfamily
AI20_10915	COG3220	belongs to the UPF0276 family
AI20_10935	COG1294	oxidase, subunit
AI20_10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_10955	COG2979	Protein of unknown function (DUF533)
AI20_10985	COG2271	Major facilitator Superfamily
AI20_10990	COG0583	DNA-binding transcription factor activity
AI20_11000	COG2807	transmembrane transport
AI20_11010	COG1187	pseudouridine synthase activity
AI20_11035	COG1403	HNH endonuclease
AI20_11045	COG2964	Protein conserved in bacteria
AI20_11050	COG3681	Belongs to the UPF0597 family
AI20_11060	COG0814	amino acid
AI20_11065	COG0840	transmembrane signaling receptor activity
AI20_11080	COG0583	DNA-binding transcription factor activity
AI20_11085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AI20_11095	COG1166	arginine decarboxylase activity
AI20_11105	COG2195	Cleaves the N-terminal amino acid of tripeptides
AI20_11135	COG0583	DNA-binding transcription factor activity
AI20_11145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AI20_11155	COG0840	transmembrane signaling receptor activity
AI20_11160	COG0302	gtp cyclohydrolase
AI20_11170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AI20_11175	COG2267	carboxylic ester hydrolase activity
AI20_11180	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AI20_11195	COG0314	molybdopterin synthase activity
AI20_11200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AI20_11205	COG0315	cyclic pyranopterin monophosphate synthase activity
AI20_11210	COG0521	Mo-molybdopterin cofactor biosynthetic process
AI20_11215	COG3005	denitrification pathway
AI20_11225	COG0348	domain, Protein
AI20_11230	COG0437	4 iron, 4 sulfur cluster binding
AI20_11235	COG0243	molybdopterin cofactor binding
AI20_11245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_11245	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_11250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AI20_11255	COG3850	Histidine kinase
AI20_11260	COG2197	response regulator
AI20_11270	COG2205	protein histidine kinase activity
AI20_11270	COG0784	Response regulator, receiver
AI20_11290	COG0121	glutamine amidotransferase
AI20_11295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AI20_11300	COG1960	acyl-CoA dehydrogenase activity
AI20_11310	COG0784	Response regulator, receiver
AI20_11310	COG3437	response regulator, receiver
AI20_11320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AI20_11325	COG0328	RNA-DNA hybrid ribonuclease activity
AI20_11330	COG2226	methyltransferase
AI20_11335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AI20_11340	COG1388	LysM domain
AI20_11340	COG0741	lytic transglycosylase activity
AI20_11345	COG3021	interspecies interaction between organisms
AI20_11355	COG1607	acyl-coa hydrolase
AI20_11370	COG0741	lytic transglycosylase activity
AI20_11380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AI20_11405	COG0729	surface antigen
AI20_11415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AI20_11420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AI20_11430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AI20_11440	COG4134	Bacterial extracellular solute-binding protein
AI20_11450	COG4136	ATPase activity
AI20_11455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AI20_11460	COG2951	lytic endotransglycosylase activity
AI20_11475	COG1846	Transcriptional regulator
AI20_11485	COG0033	Phosphoglucomutase
AI20_11490	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AI20_11495	COG0596	Alpha beta hydrolase
AI20_11510	COG0716	FMN binding
AI20_11520	COG0735	belongs to the Fur family
AI20_11525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_11535	COG1263	PTS System
AI20_11535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_11535	COG2190	(PTS) system
AI20_11540	COG0363	glucosamine-6-phosphate deaminase activity
AI20_11545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_11550	COG1940	carbohydrate kinase activity
AI20_11550	COG1846	Transcriptional regulator
AI20_11555	COG2194	sulfuric ester hydrolase activity
AI20_11560	COG0217	transcriptional regulatory protein
AI20_11565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AI20_11575	COG4106	trans-aconitate 2-methyltransferase activity
AI20_11580	COG0500	methyltransferase
AI20_11600	COG0450	alkyl hydroperoxide reductase
AI20_11605	COG0583	DNA-binding transcription factor activity
AI20_11620	COG0791	NLP P60 protein
AI20_11635	COG1309	transcriptional regulator
AI20_11675	COG0534	Mate efflux family protein
AI20_11685	COG2841	Protein conserved in bacteria
AI20_11690	COG2169	Transcriptional regulator
AI20_11690	COG1917	Cupin 2, conserved barrel domain protein
AI20_11695	COG2366	antibiotic biosynthetic process
AI20_11700	COG0674	pyruvate-flavodoxin oxidoreductase activity
AI20_11700	COG1013	pyruvate-flavodoxin oxidoreductase activity
AI20_11700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AI20_11700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AI20_11710	COG3217	Mosc domain protein beta barrel domain protein
AI20_11710	COG3217	Mosc domain protein beta barrel domain protein
AI20_11710	COG0633	Ferredoxin
AI20_11710	COG0633	Ferredoxin
AI20_11720	COG0501	Belongs to the peptidase M48B family
AI20_11725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AI20_11730	COG0596	Alpha beta hydrolase
AI20_11730	COG2226	methyltransferase
AI20_11730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AI20_11735	COG0156	8-amino-7-oxononanoate synthase activity
AI20_11740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AI20_11760	COG0017	Asparaginyl-tRNA synthetase
AI20_11765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AI20_11780	COG3069	C4-dicarboxylate transmembrane transporter activity
AI20_11790	COG0583	DNA-binding transcription factor activity
AI20_11795	COG1393	Belongs to the ArsC family
AI20_11800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AI20_11805	COG1876	peptidase activity
AI20_11815	COG3263	regulation of cellular component size
AI20_11835	COG1280	lysine exporter protein (LysE YggA)
AI20_11860	COG1957	nucleoside hydrolase
AI20_11865	COG0564	pseudouridine synthase activity
AI20_11870	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AI20_11875	COG1454	alcohol dehydrogenase
AI20_11880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_11885	COG0702	epimerase
AI20_11890	COG2914	Belongs to the UPF0125 (RnfH) family
AI20_11895	COG2867	negative regulation of translational initiation
AI20_11900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AI20_11915	COG0732	type I restriction modification DNA specificity domain
AI20_11940	COG0583	DNA-binding transcription factor activity
AI20_11945	COG3048	D-serine ammonia-lyase activity
AI20_11955	COG0659	secondary active sulfate transmembrane transporter activity
AI20_11960	COG0538	isocitrate dehydrogenase activity
AI20_11965	COG2207	Transcriptional regulator
AI20_11985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_11995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AI20_12000	COG1263	PTS System
AI20_12000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_12005	COG1609	Transcriptional regulator
AI20_12015	COG0456	acetyltransferase
AI20_12025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_12025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_12025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_12035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_12045	COG1187	pseudouridine synthase activity
AI20_12055	COG0482	sulfurtransferase activity
AI20_12060	COG2915	High frequency lysogenization protein hflD homolog
AI20_12065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AI20_12070	COG2850	peptidyl-arginine hydroxylation
AI20_12080	COG3153	acetyltransferase
AI20_12090	COG0625	glutathione transferase activity
AI20_12095	COG0259	pyridoxamine-phosphate oxidase activity
AI20_12110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_12110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_12115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AI20_12135	COG4235	cytochrome complex assembly
AI20_12135	COG3088	subunit of a heme lyase
AI20_12140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_12145	COG1138	Cytochrome C-type biogenesis protein
AI20_12150	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AI20_12155	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_12160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_12165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_12180	COG0835	chemotaxis
AI20_12190	COG1192	Involved in chromosome partitioning
AI20_12200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_12210	COG0643	Histidine kinase
AI20_12210	COG2198	Histidine kinase
AI20_12215	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AI20_12230	COG0455	bacterial-type flagellum organization
AI20_12240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AI20_12250	COG1684	flagellar biosynthetic protein fliR
AI20_12255	COG1987	bacterial-type flagellum assembly
AI20_12305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AI20_12315	COG1677	Flagellar hook-basal body complex protein FliE
AI20_12330	COG1393	Belongs to the ArsC family
AI20_12335	COG0798	PFAM Bile acid sodium symporter
AI20_12350	COG0640	Transcriptional regulator
AI20_12355	COG1342	Belongs to the UPF0251 family
AI20_12370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AI20_12375	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AI20_12375	COG3064	Membrane
AI20_12375	COG1073	alpha beta
AI20_12390	COG2274	protein secretion by the type I secretion system
AI20_12400	COG2274	protein secretion by the type I secretion system
AI20_12405	COG0745	RESPONSE REGULATOR receiver
AI20_12420	COG1737	Transcriptional regulator
AI20_12425	COG0469	pyruvate kinase activity
AI20_12435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_12440	COG1960	acyl-CoA dehydrogenase activity
AI20_12450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AI20_12460	COG0243	molybdopterin cofactor binding
AI20_12465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AI20_12470	COG0583	DNA-binding transcription factor activity
AI20_12490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AI20_12495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AI20_12500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AI20_12505	COG1012	belongs to the aldehyde dehydrogenase family
AI20_12505	COG1454	alcohol dehydrogenase
AI20_12515	COG1454	alcohol dehydrogenase
AI20_12515	COG1012	belongs to the aldehyde dehydrogenase family
AI20_12520	COG1882	Formate acetyltransferase
AI20_12525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_12530	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AI20_12535	COG4869	propanediol catabolic process
AI20_12555	COG5002	protein histidine kinase activity
AI20_12560	COG0745	RESPONSE REGULATOR receiver
AI20_12565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_12570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_12595	COG1376	ErfK ybiS ycfS ynhG family protein
AI20_12595	COG1388	LysM domain
AI20_12610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AI20_12615	COG0791	NLP P60 protein
AI20_12625	COG3118	belongs to the thioredoxin family
AI20_12635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AI20_12645	COG0788	formyltetrahydrofolate deformylase activity
AI20_12655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_12680	COG0366	Alpha amylase catalytic
AI20_12690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AI20_12695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AI20_12700	COG0673	inositol 2-dehydrogenase activity
AI20_12735	COG1032	radical SAM domain protein
AI20_12755	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_12760	COG1280	lysine exporter protein (LysE YggA)
AI20_12770	COG1032	radical SAM domain protein
AI20_12780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_12785	COG1566	PFAM secretion protein HlyD family protein
AI20_12790	COG2199	diguanylate cyclase activity
AI20_12790	COG2203	Gaf domain
AI20_12795	COG1752	Esterase of the alpha-beta hydrolase superfamily
AI20_12800	COG0733	neurotransmitter:sodium symporter activity
AI20_12830	COG0281	malic enzyme
AI20_12835	COG2207	Transcriptional regulator
AI20_12840	COG0534	Mate efflux family protein
AI20_12850	COG0745	RESPONSE REGULATOR receiver
AI20_12850	COG3706	GGDEF domain
AI20_12855	COG2233	PERMEase
AI20_12860	COG0095	Lipoate-protein ligase
AI20_12865	COG1115	amino acid carrier protein
AI20_12870	COG0019	diaminopimelate decarboxylase activity
AI20_12890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AI20_12900	COG1126	abc transporter atp-binding protein
AI20_12905	COG0765	amino acid transport
AI20_12910	COG4597	amino acid ABC transporter
AI20_12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_12930	COG1131	(ABC) transporter
AI20_12935	COG0545	Peptidyl-prolyl cis-trans isomerase
AI20_12960	COG4783	chaperone-mediated protein folding
AI20_12970	COG5002	protein histidine kinase activity
AI20_12975	COG0745	RESPONSE REGULATOR receiver
AI20_12980	COG0346	lactoylglutathione lyase activity
AI20_12985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AI20_12990	COG1960	acyl-CoA dehydrogenase activity
AI20_12995	COG3284	Transcriptional regulator
AI20_13000	COG1012	belongs to the aldehyde dehydrogenase family
AI20_13010	COG0697	spore germination
AI20_13015	COG4565	transcriptional regulatory protein
AI20_13020	COG3290	protein histidine kinase activity
AI20_13025	COG0281	malic enzyme
AI20_13040	COG1846	Transcriptional regulator
AI20_13045	COG1566	PFAM secretion protein HlyD family protein
AI20_13075	COG0602	queuosine metabolic process
AI20_13080	COG1328	CTP reductase activity
AI20_13090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AI20_13095	COG3115	cell septum assembly
AI20_13100	COG1196	nuclear chromosome segregation
AI20_13110	COG2860	membrane
AI20_13120	COG3108	Peptidase M15
AI20_13125	COG2989	Protein conserved in bacteria
AI20_13140	COG0463	Glycosyl transferase, family 2
AI20_13155	COG0366	Alpha amylase catalytic
AI20_13195	COG3706	GGDEF domain
AI20_13200	COG0037	tRNA processing
AI20_13205	COG3590	peptidase
AI20_13215	COG0488	(ABC) transporter
AI20_13225	COG0531	amino acid
AI20_13230	COG0814	amino acid
AI20_13245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AI20_13250	COG1982	Orn Lys Arg decarboxylase major
AI20_13255	COG0531	amino acid
AI20_13260	COG3710	Transcriptional regulator
AI20_13265	COG0825	malonyl-CoA metabolic process
AI20_13275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AI20_13280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_13285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_13290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_13295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_13310	COG0750	zinc metalloprotease
AI20_13315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AI20_13320	COG0575	Belongs to the CDS family
AI20_13330	COG0233	cytoplasmic translational termination
AI20_13335	COG0528	UMP kinase activity
AI20_13340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AI20_13345	COG0052	Belongs to the universal ribosomal protein uS2 family
AI20_13350	COG0024	Methionine aminopeptidase
AI20_13355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AI20_13360	COG2171	N-acyltransferase activity
AI20_13390	COG0564	pseudouridine synthase activity
AI20_13395	COG3098	single-species biofilm formation
AI20_13420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AI20_13430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AI20_13430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AI20_13440	COG3706	GGDEF domain
AI20_13445	COG1611	Belongs to the LOG family
AI20_13450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_13455	COG0473	3-isopropylmalate dehydrogenase activity
AI20_13465	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AI20_13470	COG2363	Small membrane protein
AI20_13480	COG0583	DNA-binding transcription factor activity
AI20_13485	COG0840	transmembrane signaling receptor activity
AI20_13490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AI20_13505	COG1477	protein flavinylation
AI20_13510	COG2871	sodium ion transport
AI20_13515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_13520	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_13525	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_13530	COG1805	sodium ion transport
AI20_13535	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_13540	COG0271	Belongs to the BolA IbaG family
AI20_13545	COG2813	Specifically methylates the guanine in position
AI20_13555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AI20_13565	COG2211	Major facilitator Superfamily
AI20_13570	COG3248	Nucleoside-binding outer membrane protein
AI20_13575	COG1666	GTP binding
AI20_13580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AI20_13585	COG0693	protein deglycase activity
AI20_13640	COG2771	luxR family
AI20_13655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_13655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AI20_13660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AI20_13670	COG1151	hydroxylamine reductase activity
AI20_13675	COG0783	Belongs to the Dps family
AI20_13700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AI20_13715	COG4221	oxidoreductase activity
AI20_13725	COG0415	Belongs to the DNA photolyase family
AI20_13730	COG0789	Transcriptional regulator
AI20_13735	COG3272	Protein of unknown function (DUF1722)
AI20_13765	COG1605	Chorismate mutase
AI20_13765	COG0077	Prephenate dehydratase
AI20_13850	COG5377	YqaJ viral recombinase family
AI20_13895	COG2003	Belongs to the UPF0758 family
AI20_13940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_13980	COG1349	DNA-binding transcription factor activity
AI20_13985	COG2084	Dehydrogenase
AI20_13995	COG0235	Class ii aldolase
AI20_14000	COG3622	Belongs to the hyi family
AI20_14005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_14010	COG2610	gluconate transmembrane transporter activity
AI20_14020	COG0840	transmembrane signaling receptor activity
AI20_14030	COG0300	oxidoreductase activity
AI20_14055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AI20_14085	COG0826	peptidase U32
AI20_14090	COG1280	lysine exporter protein (LysE YggA)
AI20_14120	COG2198	Histidine kinase
AI20_14120	COG0643	Histidine kinase
AI20_14130	COG0835	chemotaxis
AI20_14135	COG0840	transmembrane signaling receptor activity
AI20_14145	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AI20_14150	COG2201	protein-glutamate methylesterase activity
AI20_14155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AI20_14190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_14200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_14205	COG0305	Participates in initiation and elongation during chromosome replication
AI20_14220	COG2200	EAL domain
AI20_14225	COG0737	Belongs to the 5'-nucleotidase family
AI20_14245	COG2204	response regulator
AI20_14250	COG0545	Peptidyl-prolyl cis-trans isomerase
AI20_14260	COG2900	Belongs to the SlyX family
AI20_14265	COG1047	Peptidyl-prolyl cis-trans
AI20_14270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AI20_14280	COG0835	chemotaxis
AI20_14280	COG0784	Response regulator, receiver
AI20_14285	COG0429	hydrolase of the alpha beta-hydrolase fold
AI20_14290	COG3089	Belongs to the UPF0270 family
AI20_14300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_14305	COG0463	Glycosyl transferase, family 2
AI20_14310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AI20_14310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_14315	COG0726	polysaccharide deacetylase
AI20_14320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AI20_14325	COG2076	Multidrug Resistance protein
AI20_14330	COG2076	Multidrug Resistance protein
AI20_14335	COG3954	Phosphoribulokinase
AI20_14350	COG1765	OsmC-like protein
AI20_14355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AI20_14365	COG3397	chitin binding
AI20_14380	COG2202	Pas domain
AI20_14380	COG2205	protein histidine kinase activity
AI20_14390	COG3655	Transcriptional regulator
AI20_14400	COG2814	Major facilitator Superfamily
AI20_14405	COG4771	TonB-dependent receptor
AI20_14425	COG0748	coenzyme F420 binding
AI20_14430	COG3721	Heme iron utilization protein
AI20_14440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_14445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AI20_14470	COG0741	lytic transglycosylase activity
AI20_14475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AI20_14490	COG0488	(ABC) transporter
AI20_14500	COG2252	PERMEase
AI20_14505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AI20_14510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AI20_14515	COG3178	'Phosphotransferase
AI20_14520	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AI20_14530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AI20_14535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AI20_14545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AI20_14555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AI20_14560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_14575	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_14585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AI20_14590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AI20_14600	COG0142	geranyltranstransferase activity
AI20_14605	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AI20_14610	COG0330	HflC and HflK could
AI20_14615	COG0330	HflC and HflK could
AI20_14620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AI20_14625	COG1923	regulation of RNA biosynthetic process
AI20_14630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AI20_14635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AI20_14650	COG0802	atpase or kinase
AI20_14655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AI20_14655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AI20_14680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AI20_14685	COG2011	ABC-type metal ion transport system permease component
AI20_14690	COG1464	Belongs to the NlpA lipoprotein family
AI20_14700	COG0840	transmembrane signaling receptor activity
AI20_14725	COG0784	Response regulator, receiver
AI20_14725	COG2198	Histidine kinase
AI20_14725	COG5002	protein histidine kinase activity
AI20_14745	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AI20_14760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AI20_14765	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AI20_14775	COG2716	regulation of RNA biosynthetic process
AI20_14780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AI20_14785	COG3013	Belongs to the UPF0304 family
AI20_14790	COG3092	negative regulation of chromosome organization
AI20_14795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AI20_14800	COG0280	phosphate acetyltransferase
AI20_14800	COG0857	belongs to the CobB CobQ family
AI20_14805	COG0440	acetolactate synthase activity
AI20_14810	COG0028	Belongs to the TPP enzyme family
AI20_14825	COG0671	phosphoesterase, PA-phosphatase related
AI20_14835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AI20_14840	COG0473	3-isopropylmalate dehydrogenase activity
AI20_14845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AI20_14850	COG0066	3-isopropylmalate dehydratase activity
AI20_14865	COG4143	(ABC) transporter
AI20_14870	COG1178	ABC-type Fe3 transport system permease component
AI20_14875	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AI20_14880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AI20_14890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AI20_14925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_14930	COG0564	pseudouridine synthase activity
AI20_14935	COG3300	MHYT domain
AI20_14935	COG5001	Diguanylate cyclase
AI20_14945	COG0459	protein refolding
AI20_14950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AI20_14960	COG3030	protein affecting phage T7 exclusion by the F plasmid
AI20_14965	COG1027	Aspartate ammonia-lyase
AI20_14970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AI20_14975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AI20_14980	COG0477	Major facilitator Superfamily
AI20_14990	COG3227	Zinc metalloprotease (Elastase)
AI20_14995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_15000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_15010	COG0673	inositol 2-dehydrogenase activity
AI20_15020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AI20_15025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AI20_15030	COG3036	rescue of stalled ribosome
AI20_15045	COG0138	bifunctional purine biosynthesis protein purh
AI20_15050	COG0151	Belongs to the GarS family
AI20_15070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AI20_15075	COG0358	DNA primase activity
AI20_15080	COG1610	YqeY-like protein
AI20_15090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AI20_15100	COG4942	peptidase
AI20_15100	COG1388	LysM domain
AI20_15105	COG1238	metal cluster binding
AI20_15110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AI20_15115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AI20_15120	COG0585	pseudouridine synthase activity
AI20_15130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AI20_15135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AI20_15140	COG0148	phosphopyruvate hydratase activity
AI20_15145	COG0504	CTP synthase activity
AI20_15150	COG3956	TIGRFAM MazG family protein
AI20_15155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AI20_15160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_15170	COG4807	Protein conserved in bacteria
AI20_15175	COG3023	N-Acetylmuramoyl-L-alanine amidase
AI20_15180	COG1349	DNA-binding transcription factor activity
AI20_15190	COG2222	sugar isomerase
AI20_15195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_15205	COG3716	PTS system mannose fructose sorbose family IID component
AI20_15210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_15215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_15225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AI20_15230	COG1381	Involved in DNA repair and RecF pathway recombination
AI20_15240	COG0571	ribonuclease III activity
AI20_15245	COG0681	Belongs to the peptidase S26 family
AI20_15250	COG0481	GTPase activity
AI20_15265	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AI20_15270	COG1595	DNA-templated transcription, initiation
AI20_15275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AI20_15285	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AI20_15335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_15345	COG0126	phosphoglycerate kinase activity
AI20_15350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AI20_15355	COG1940	carbohydrate kinase activity
AI20_15360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AI20_15365	COG2816	NAD+ diphosphatase activity
AI20_15375	COG4991	sh3 domain protein
AI20_15380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AI20_15395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AI20_15410	COG2982	Protein involved in outer membrane biogenesis
AI20_15415	COG1505	serine-type exopeptidase activity
AI20_15420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AI20_15425	COG0765	amino acid transport
AI20_15430	COG0765	amino acid transport
AI20_15435	COG1126	abc transporter atp-binding protein
AI20_15440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_15445	COG1136	(ABC) transporter
AI20_15445	COG0577	efflux transmembrane transporter activity
AI20_15450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_15455	COG0745	RESPONSE REGULATOR receiver
AI20_15460	COG2205	protein histidine kinase activity
AI20_15495	COG2070	2-Nitropropane dioxygenase
AI20_15520	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AI20_15540	COG0513	Belongs to the DEAD box helicase family
AI20_15550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AI20_15555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AI20_15575	COG2957	Belongs to the agmatine deiminase family
AI20_15585	COG2852	Protein conserved in bacteria
AI20_15595	COG1902	pentaerythritol trinitrate reductase activity
AI20_15615	COG3706	GGDEF domain
AI20_15615	COG0745	RESPONSE REGULATOR receiver
AI20_15620	COG5001	Diguanylate cyclase
AI20_15640	COG0714	Associated with various cellular activities
AI20_15650	COG0456	acetyltransferase
AI20_15660	COG1022	Amp-dependent synthetase and ligase
AI20_15665	COG2918	glutathione biosynthetic process
AI20_15670	COG0612	Peptidase, M16
AI20_15675	COG1238	metal cluster binding
AI20_15715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_15720	COG0359	binds to the 23S rRNA
AI20_15725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AI20_15730	COG0360	Binds together with S18 to 16S ribosomal RNA
AI20_15735	COG1914	H( )-stimulated, divalent metal cation uptake system
AI20_15745	COG0583	DNA-binding transcription factor activity
AI20_15755	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_15760	COG2814	Major facilitator Superfamily
AI20_15780	COG0697	spore germination
AI20_15785	COG2153	protein acetylation
AI20_15795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AI20_15820	COG0557	exoribonuclease II activity
AI20_15825	COG3706	GGDEF domain
AI20_15830	COG1854	S-ribosylhomocysteine lyase activity
AI20_15845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AI20_15845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AI20_15905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AI20_15910	COG1047	Peptidyl-prolyl cis-trans
AI20_15915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AI20_15920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AI20_15925	COG0196	riboflavin kinase activity
AI20_15930	COG0728	peptidoglycan biosynthetic process
AI20_15935	COG0268	Binds directly to 16S ribosomal RNA
AI20_15940	COG0640	Transcriptional regulator
AI20_15945	COG0583	DNA-binding transcription factor activity
AI20_15955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_15960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AI20_15965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AI20_15975	COG1051	belongs to the nudix hydrolase family
AI20_15980	COG3066	DNA modification
AI20_15990	COG0335	large ribosomal subunit rRNA binding
AI20_15995	COG0336	Belongs to the RNA methyltransferase TrmD family
AI20_16000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AI20_16005	COG0228	four-way junction DNA binding
AI20_16010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AI20_16015	COG4137	Cytochrome C assembly protein
AI20_16020	COG4536	flavin adenine dinucleotide binding
AI20_16025	COG1959	2 iron, 2 sulfur cluster binding
AI20_16030	COG1017	nitric oxide dioxygenase activity
AI20_16030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_16035	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AI20_16040	COG0039	L-malate dehydrogenase activity
AI20_16045	COG4160	amino acid transport
AI20_16050	COG4215	(ABC) transporter
AI20_16055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_16060	COG1126	abc transporter atp-binding protein
AI20_16065	COG1438	arginine binding
AI20_16070	COG2837	iron assimilation
AI20_16075	COG3842	ATPase activity
AI20_16085	COG1840	ABC-type Fe3 transport system, periplasmic component
AI20_16090	COG0347	Belongs to the P(II) protein family
AI20_16105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_16110	COG0583	DNA-binding transcription factor activity
AI20_16125	COG1929	Belongs to the glycerate kinase type-1 family
AI20_16130	COG2610	gluconate transmembrane transporter activity
AI20_16135	COG3835	regulator
AI20_16140	COG3112	Uncharacterised protein family (UPF0231)
AI20_16155	COG3568	Endonuclease Exonuclease Phosphatase
AI20_16170	COG0513	Belongs to the DEAD box helicase family
AI20_16210	COG1448	Aminotransferase
AI20_16225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_16230	COG1328	CTP reductase activity
AI20_16250	COG4946	Tricorn protease homolog
AI20_16250	COG0793	Belongs to the peptidase S41A family
AI20_16285	COG3397	chitin binding
AI20_16290	COG0583	DNA-binding transcription factor activity
AI20_16300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AI20_16305	COG4208	sulfate ABC transporter
AI20_16310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AI20_16320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AI20_16325	COG3174	membrane
AI20_16330	COG0110	maltose O-acetyltransferase activity
AI20_16355	COG0165	Argininosuccinate lyase
AI20_16360	COG0137	argininosuccinate synthase activity
AI20_16370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AI20_16375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AI20_16385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AI20_16405	COG1280	lysine exporter protein (LysE YggA)
AI20_16415	COG0460	homoserine dehydrogenase
AI20_16415	COG0527	aspartate kinase activity
AI20_16420	COG0626	cystathionine gamma-synthase activity
AI20_16430	COG2207	Transcriptional regulator
AI20_16430	COG3708	Transcriptional regulator
AI20_16435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_16440	COG0814	amino acid
AI20_16445	COG1218	3'(2'),5'-bisphosphate nucleotidase
AI20_16450	COG0494	nUDIX hydrolase
AI20_16455	COG1011	Hydrolase
AI20_16470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AI20_16485	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AI20_16495	COG3156	type II secretion system protein K
AI20_16500	COG4795	General secretion pathway protein
AI20_16505	COG2165	general secretion pathway protein
AI20_16515	COG2165	general secretion pathway protein
AI20_16520	COG1459	type II secretion system
AI20_16525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_16535	COG3031	protein transport across the cell outer membrane
AI20_16545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AI20_16570	COG0456	acetyltransferase
AI20_16575	COG3133	Outer membrane lipoprotein
AI20_16590	COG2771	luxR family
AI20_16595	COG3916	Acyl-homoserine-lactone synthase
AI20_16605	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AI20_16610	COG1309	transcriptional regulator
AI20_16625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_16625	COG2213	PTS system mannitol-specific
AI20_16630	COG0246	Mannitol dehydrogenase
AI20_16635	COG3722	fumarate hydratase activity
AI20_16640	COG3263	regulation of cellular component size
AI20_16665	COG1671	Belongs to the UPF0178 family
AI20_16680	COG1988	membrane-bound metal-dependent
AI20_16685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_16690	COG0513	Belongs to the DEAD box helicase family
AI20_16725	COG1575	Belongs to the MenA family. Type 1 subfamily
AI20_16730	COG1169	isochorismate synthase
AI20_16735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AI20_16740	COG0596	Alpha beta hydrolase
AI20_16745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AI20_16750	COG1441	menaquinone biosynthetic process
AI20_16755	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_16770	COG3539	Fimbrial protein
AI20_16775	COG3121	Chaperone
AI20_16780	COG3188	usher protein
AI20_16790	COG3539	Fimbrial protein
AI20_16805	COG3291	Pkd domain containing protein
AI20_16810	COG2949	membrane
AI20_16825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AI20_16830	COG5380	lipid catabolic process
AI20_16845	COG4533	DNA binding
AI20_16855	COG2873	o-acetylhomoserine
AI20_16865	COG1979	alcohol dehydrogenase
AI20_16880	COG4221	oxidoreductase activity
AI20_16900	COG1285	pathogenesis
AI20_16920	COG1368	sulfuric ester hydrolase activity
AI20_16925	COG1522	sequence-specific DNA binding
AI20_16935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AI20_16940	COG1418	mRNA catabolic process
AI20_16945	COG1058	Belongs to the CinA family
AI20_16945	COG1546	Belongs to the CinA family
AI20_16955	COG0842	Transport permease protein
AI20_16955	COG1129	ABC transporter
AI20_16975	COG0561	phosphatase activity
AI20_16980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AI20_17000	COG1011	Hydrolase
AI20_17015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AI20_17020	COG0019	diaminopimelate decarboxylase activity
AI20_17025	COG1965	Belongs to the frataxin family
AI20_17030	COG0400	carboxylic ester hydrolase activity
AI20_17035	COG3072	Adenylate cyclase
AI20_17040	COG0181	hydroxymethylbilane synthase activity
AI20_17050	COG2959	enzyme of heme biosynthesis
AI20_17065	COG1494	fructose-1,6-bisphosphatase
AI20_17100	COG0456	acetyltransferase
AI20_17105	COG1733	regulation of RNA biosynthetic process
AI20_17125	COG3932	Exopolysaccharide synthesis, ExoD
AI20_17130	COG0814	amino acid
AI20_17135	COG3706	GGDEF domain
AI20_17150	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AI20_17165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AI20_17170	COG2022	thiamine diphosphate biosynthetic process
AI20_17180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AI20_17185	COG0352	thiamine-phosphate diphosphorylase activity
AI20_17190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AI20_17215	COG0745	RESPONSE REGULATOR receiver
AI20_17225	COG0189	ligase activity
AI20_17245	COG0582	viral genome integration into host DNA
AI20_17265	COG1715	Restriction endonuclease
AI20_17275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AI20_17310	COG1639	'signal transduction protein
AI20_17320	COG2321	neutral zinc metallopeptidase
AI20_17325	COG3700	Belongs to the class B bacterial acid phosphatase family
AI20_17345	COG1366	Belongs to the anti-sigma-factor antagonist family
AI20_17355	COG5002	protein histidine kinase activity
AI20_17355	COG0784	Response regulator, receiver
AI20_17355	COG2205	protein histidine kinase activity
AI20_17360	COG3437	response regulator, receiver
AI20_17370	COG0477	Major facilitator Superfamily
AI20_17385	COG0312	modulator of DNA gyrase
AI20_17390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AI20_17405	COG3164	Protein of unknown function
AI20_17410	COG1530	ribonuclease E activity
AI20_17415	COG0424	maF-like protein
AI20_17420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AI20_17425	COG1792	Involved in formation and maintenance of cell shape
AI20_17430	COG1077	Cell shape determining protein MreB Mrl
AI20_17475	COG1459	type II secretion system
AI20_17480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_17530	COG2199	diguanylate cyclase activity
AI20_17530	COG2200	EAL domain
AI20_17535	COG2200	EAL domain
AI20_17540	COG0387	Pfam Sodium calcium exchanger
AI20_17545	COG2986	histidine ammonia-lyase
AI20_17550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AI20_17555	COG0010	Belongs to the arginase family
AI20_17560	COG1228	amidohydrolase
AI20_17565	COG2188	Transcriptional regulator
AI20_17570	COG0288	reversible hydration of carbon dioxide
AI20_17580	COG2177	Part of the ABC transporter FtsEX involved in
AI20_17585	COG2884	Cell division ATP-binding protein ftsE
AI20_17590	COG0552	protein localization to endoplasmic reticulum
AI20_17595	COG0742	ribosomal rna small subunit methyltransferase
AI20_17620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_17630	COG0741	lytic transglycosylase activity
AI20_17655	COG2095	MarC family integral membrane protein
AI20_17670	COG1301	dicarboxylic acid transport
AI20_17695	COG3714	YhhN family
AI20_17720	COG1770	oligopeptidase
AI20_17735	COG4221	oxidoreductase activity
AI20_17740	COG0583	DNA-binding transcription factor activity
AI20_17745	COG2249	NAD(P)H dehydrogenase (quinone) activity
AI20_17800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AI20_17805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AI20_17810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AI20_17815	COG0201	protein transport
AI20_17820	COG0200	Binds to the 23S rRNA
AI20_17830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AI20_17835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AI20_17840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AI20_17845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AI20_17850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AI20_17855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AI20_17860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AI20_17865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AI20_17870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AI20_17875	COG0255	Belongs to the universal ribosomal protein uL29 family
AI20_17880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AI20_17885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AI20_17890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AI20_17895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AI20_17900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AI20_17905	COG0089	rRNA binding
AI20_17910	COG0088	Forms part of the polypeptide exit tunnel
AI20_17915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AI20_17920	COG0051	transcription antitermination factor activity, RNA binding
AI20_17935	COG0745	RESPONSE REGULATOR receiver
AI20_17940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AI20_17945	COG2183	response to ionizing radiation
AI20_17965	COG0596	Alpha beta hydrolase
AI20_17970	COG1040	competence protein
AI20_17975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AI20_17975	COG0316	Belongs to the HesB IscA family
AI20_17980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AI20_17985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AI20_17990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_17995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AI20_18000	COG4942	peptidase
AI20_18010	COG1609	Transcriptional regulator
AI20_18015	COG0800	Aldolase
AI20_18020	COG0129	dihydroxy-acid dehydratase activity
AI20_18025	COG3265	gluconokinase activity
AI20_18030	COG2610	gluconate transmembrane transporter activity
AI20_18035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_18040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AI20_18050	COG0456	acetyltransferase
AI20_18070	COG1490	D-aminoacyl-tRNA deacylase activity
AI20_18075	COG1295	ribonuclease BN
AI20_18085	COG0174	glutamine synthetase
AI20_18095	COG3852	Histidine kinase
AI20_18100	COG2204	response regulator
AI20_18105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AI20_18110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AI20_18120	COG3078	GTPase activator activity
AI20_18135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AI20_18145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AI20_18155	COG0009	L-threonylcarbamoyladenylate synthase
AI20_18165	COG0551	DNA topoisomerase type I activity
AI20_18170	COG2922	Belongs to the Smg family
AI20_18175	COG0758	DNA mediated transformation
AI20_18185	COG0242	peptide deformylase activity
AI20_18190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AI20_18195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_18195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_18200	COG0569	domain protein
AI20_18205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_18210	COG1322	Protein conserved in bacteria
AI20_18230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_18235	COG0686	Belongs to the AlaDH PNT family
AI20_18240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AI20_18240	COG0519	Catalyzes the synthesis of GMP from XMP
AI20_18255	COG1396	sequence-specific DNA binding
AI20_18260	COG1012	belongs to the aldehyde dehydrogenase family
AI20_18270	COG2962	Rard protein
AI20_18280	COG1280	lysine exporter protein (LysE YggA)
AI20_18290	COG2391	methyltransferase activity
AI20_18300	COG1280	lysine exporter protein (LysE YggA)
AI20_18335	COG3161	chorismate lyase activity
AI20_18365	COG0583	DNA-binding transcription factor activity
AI20_18385	COG1943	Transposase
AI20_18395	COG0210	DNA helicase
AI20_18425	COG0583	DNA-binding transcription factor activity
AI20_18445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AI20_18450	COG0385	Bile acid
AI20_18455	COG0531	amino acid
AI20_18460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_18465	COG0531	amino acid
AI20_18470	COG2731	YhcH YjgK YiaL family protein
AI20_18475	COG3250	beta-galactosidase activity
AI20_18480	COG1609	Transcriptional regulator
AI20_18520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AI20_18525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_18525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_18530	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AI20_18535	COG3074	FtsZ-dependent cytokinesis
AI20_18545	COG1045	serine acetyltransferase
AI20_18555	COG0745	RESPONSE REGULATOR receiver
AI20_18560	COG2205	protein histidine kinase activity
AI20_18565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AI20_18570	COG0534	Mate efflux family protein
AI20_18590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AI20_18595	COG2937	Belongs to the GPAT DAPAT family
AI20_18600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AI20_18605	COG3161	chorismate lyase activity
AI20_18610	COG1580	Controls the rotational direction of flagella during chemotaxis
AI20_18630	COG0604	alcohol dehydrogenase
AI20_18635	COG1609	Transcriptional regulator
AI20_18655	COG1519	Transferase
AI20_18660	COG0859	PFAM glycosyl transferase family 9
AI20_18665	COG0463	Glycosyl transferase, family 2
AI20_18670	COG0859	PFAM glycosyl transferase family 9
AI20_18675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AI20_18680	COG2990	Protein conserved in bacteria
AI20_18685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AI20_18695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AI20_18705	COG2003	Belongs to the UPF0758 family
AI20_18710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AI20_18715	COG0756	dUTP diphosphatase activity
AI20_18720	COG1309	transcriptional regulator
AI20_18725	COG0668	transmembrane transport
AI20_18735	COG0166	Belongs to the GPI family
AI20_18740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AI20_18745	COG0583	DNA-binding transcription factor activity
AI20_18760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_18760	COG0045	succinate-CoA ligase (ADP-forming) activity
AI20_18760	COG1042	CoA-binding domain protein
AI20_18785	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AI20_18790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_18795	COG1739	Uncharacterized protein family UPF0029
AI20_18800	COG0006	proline dipeptidase activity
AI20_18805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AI20_18810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AI20_18810	COG1024	Enoyl-CoA hydratase
AI20_18815	COG0183	Belongs to the thiolase family
AI20_18820	COG0745	RESPONSE REGULATOR receiver
AI20_18825	COG2205	protein histidine kinase activity
AI20_18840	COG0425	Belongs to the sulfur carrier protein TusA family
AI20_18845	COG0251	oxidation-reduction process
AI20_18855	COG2885	chlorophyll binding
AI20_18860	COG1335	isochorismatase
AI20_18865	COG2818	Glycosylase
AI20_18870	COG0752	glycyl-tRNA synthetase alpha subunit
AI20_18875	COG0751	glycine-tRNA ligase activity
AI20_18880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AI20_18910	COG0814	amino acid
AI20_18915	COG0348	domain, Protein
AI20_18925	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_18930	COG1773	rubredoxin
AI20_18930	COG0426	domain, Protein
AI20_18935	COG3604	Transcriptional regulator
AI20_18940	COG2188	Transcriptional regulator
AI20_18955	COG1609	Transcriptional regulator
AI20_18965	COG0559	Belongs to the binding-protein-dependent transport system permease family
AI20_19000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_19025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AI20_19035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AI20_19040	COG3118	belongs to the thioredoxin family
AI20_19045	COG0513	Belongs to the DEAD box helicase family
AI20_19050	COG0248	Ppx GppA phosphatase
AI20_19065	COG0742	ribosomal rna small subunit methyltransferase
AI20_19070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_19090	COG0084	hydrolase, TatD family'
AI20_19095	COG0805	protein transport
AI20_19100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AI20_19110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AI20_19115	COG3165	ubiquinone biosynthetic process from chorismate
AI20_19125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AI20_19130	COG0402	S-adenosylhomocysteine deaminase activity
AI20_19170	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AI20_19175	COG0848	biopolymer transport protein
AI20_19180	COG0811	peptide transport
AI20_19185	COG0811	peptide transport
AI20_19195	COG2771	luxR family
AI20_19200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AI20_19205	COG1349	DNA-binding transcription factor activity
AI20_19210	COG0745	RESPONSE REGULATOR receiver
AI20_19215	COG2205	protein histidine kinase activity
AI20_19225	COG4452	Inner membrane protein CreD
AI20_19230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AI20_19235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AI20_19240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AI20_19245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AI20_19250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AI20_19255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AI20_19260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AI20_19270	COG0356	it plays a direct role in the translocation of protons across the membrane
AI20_19280	COG1475	DNA binding
AI20_19285	COG1192	Involved in chromosome partitioning
AI20_19290	COG0357	Ribosomal RNA small subunit methyltransferase G
AI20_19295	COG0445	tRNA wobble uridine modification
AI20_19300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AI20_19305	COG4774	siderophore transport
AI20_19310	COG4615	Cyclic peptide transporter
AI20_19315	COG1120	ATPase activity
AI20_19330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AI20_19335	COG0706	membrane insertase activity
AI20_19340	COG0594	ribonuclease P activity
AI20_19350	COG1126	abc transporter atp-binding protein
AI20_19365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AI20_19370	COG0592	DNA-directed DNA polymerase activity
AI20_19380	COG0187	DNA topoisomerase II activity
AI20_19390	COG2378	regulation of single-species biofilm formation
AI20_19395	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_19400	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_19405	COG3977	Valine--pyruvate aminotransferase
AI20_19420	COG2814	Major facilitator Superfamily
AI20_19425	COG0745	RESPONSE REGULATOR receiver
AI20_19430	COG2205	protein histidine kinase activity
AI20_19455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AI20_19460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_19460	COG4191	Histidine kinase
AI20_19465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_19475	COG1309	transcriptional regulator
AI20_19510	COG2271	Major facilitator Superfamily
AI20_19515	COG1840	ABC-type Fe3 transport system, periplasmic component
AI20_19530	COG0561	phosphatase activity
AI20_19535	COG2267	carboxylic ester hydrolase activity
AI20_19545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AI20_19550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AI20_19555	COG1758	RNA polymerase activity
AI20_19565	COG0859	PFAM glycosyl transferase family 9
AI20_19570	COG3642	lipopolysaccharide core region biosynthetic process
AI20_19610	COG0589	response to stress
AI20_19615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AI20_19620	COG2199	diguanylate cyclase activity
AI20_19625	COG1528	Iron-storage protein
AI20_19630	COG2081	HI0933 family
AI20_19635	COG2223	nitrite transmembrane transporter activity
AI20_19655	COG3188	usher protein
AI20_19675	COG2205	protein histidine kinase activity
AI20_19675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_19685	COG3275	phosphorelay sensor kinase activity
AI20_19690	COG3279	Response regulator of the LytR AlgR family
AI20_19695	COG2223	nitrite transmembrane transporter activity
AI20_19700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AI20_19705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AI20_19720	COG0583	DNA-binding transcription factor activity
AI20_19730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AI20_19770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AI20_19775	COG2166	iron-sulfur cluster assembly
AI20_19780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AI20_19790	COG5001	Diguanylate cyclase
AI20_19790	COG3300	MHYT domain
AI20_19795	COG3245	cytochrome
AI20_19800	COG1063	alcohol dehydrogenase
AI20_19815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_19830	COG3306	glycosyltransferase involved in LPS biosynthesis
AI20_19850	COG4774	siderophore transport
AI20_19855	COG4607	ABC-type enterochelin transport system periplasmic component
AI20_19860	COG4604	ABC transporter, ATP-binding protein
AI20_19865	COG4605	iron ion homeostasis
AI20_19870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_19895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_19905	COG3433	isochorismatase activity
AI20_19905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_19905	COG2226	methyltransferase
AI20_19920	COG1561	YicC-like family, N-terminal region
AI20_19925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AI20_19930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AI20_19940	COG0789	Transcriptional regulator
AI20_19945	COG5001	Diguanylate cyclase
AI20_19945	COG4251	negative regulation of phosphorylation
AI20_19945	COG3706	GGDEF domain
AI20_19945	COG2203	Gaf domain
AI20_19950	COG3084	Protein conserved in bacteria
AI20_19960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AI20_19965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AI20_19970	COG3639	organic phosphonate transmembrane transporter activity
AI20_19975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AI20_19980	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AI20_19990	COG1335	isochorismatase
AI20_20000	COG1683	Conserved Protein
AI20_20005	COG0204	Acyl-transferase
AI20_20010	COG0204	Acyl-transferase
AI20_20015	COG0606	chelatase, subunit chli
AI20_20025	COG3978	acetolactate synthase activity
AI20_20030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AI20_20035	COG0129	dihydroxy-acid dehydratase activity
AI20_20065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AI20_20070	COG0254	rRNA binding
AI20_20075	COG0702	epimerase
AI20_20080	COG0281	malic enzyme
AI20_20090	COG2205	protein histidine kinase activity
AI20_20095	COG0745	RESPONSE REGULATOR receiver
AI20_20100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_20135	COG4310	Domain of unknown function (DUF2172)
AI20_20155	COG2089	acid synthase
AI20_20165	COG1083	cytidylyl-transferase
AI20_20180	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_20185	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_20200	COG1215	transferase activity, transferring glycosyl groups
AI20_20260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_20265	COG2801	Transposase and inactivated derivatives
AI20_20270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_20275	COG1086	Polysaccharide biosynthesis protein
AI20_20280	COG0366	Alpha amylase catalytic
AI20_20290	COG3187	Heat shock protein
AI20_20295	COG0443	Heat shock 70 kDa protein
AI20_20300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_20305	COG3045	CreA protein
AI20_20320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AI20_20325	COG0174	glutamine synthetase
AI20_20345	COG3842	ATPase activity
AI20_20350	COG1176	ABC-type spermidine putrescine transport system, permease component I
AI20_20355	COG1177	transmembrane transport
AI20_20360	COG2258	MOSC domain
AI20_20375	COG2050	protein possibly involved in aromatic compounds catabolism
AI20_20380	COG0514	ATP-dependent DNA helicase (RecQ)
AI20_20395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AI20_20405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AI20_20410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AI20_20420	COG2239	Acts as a magnesium transporter
AI20_20425	COG1648	precorrin-2 dehydrogenase activity
AI20_20425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AI20_20430	COG2116	formate transmembrane transporter activity
AI20_20435	COG2146	nitrite reductase [NAD(P)H] activity
AI20_20440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AI20_20450	COG0477	Major facilitator Superfamily
AI20_20455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AI20_20460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AI20_20480	COG1595	DNA-templated transcription, initiation
AI20_20485	COG3806	Anti-sigma factor
AI20_20490	COG1968	undecaprenyl-diphosphatase activity
AI20_20495	COG0667	Aldo Keto reductase
AI20_20500	COG2017	converts alpha-aldose to the beta-anomer
AI20_20505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AI20_20515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AI20_20520	COG1609	Transcriptional regulator
AI20_20525	COG3250	beta-galactosidase activity
AI20_20575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AI20_20580	COG1288	antiporter activity
AI20_20585	COG1438	arginine binding
AI20_20590	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AI20_20595	COG0540	Belongs to the ATCase OTCase family
AI20_20610	COG0688	phosphatidylethanolamine metabolic process
AI20_20625	COG3040	lipid binding
AI20_20630	COG2207	Transcriptional regulator
AI20_20635	COG1979	alcohol dehydrogenase
AI20_20640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AI20_20645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AI20_20650	COG2964	Protein conserved in bacteria
AI20_20655	COG3681	Belongs to the UPF0597 family
AI20_20665	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_20670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_20675	COG0564	pseudouridine synthase activity
AI20_20685	COG0542	response to heat
AI20_20690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AI20_20695	COG2502	aspartate--ammonia ligase
AI20_20700	COG1522	sequence-specific DNA binding
AI20_20710	COG5413	integral membrane protein
AI20_20715	COG0516	GMP reductase activity
AI20_20715	COG0517	IMP dehydrogenase activity
AI20_20720	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_20735	COG2205	protein histidine kinase activity
AI20_20745	COG2204	response regulator
AI20_20765	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AI20_20780	COG0745	RESPONSE REGULATOR receiver
AI20_20785	COG2205	protein histidine kinase activity
AI20_20795	COG0243	molybdopterin cofactor binding
AI20_20800	COG3005	denitrification pathway
AI20_20805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AI20_20825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_20830	COG0569	domain protein
AI20_20835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AI20_20860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AI20_20870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AI20_20875	COG0250	Participates in transcription elongation, termination and antitermination
AI20_20880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AI20_20885	COG0081	regulation of translation
AI20_20890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AI20_20895	COG0222	ribosome binding
AI20_20900	COG0085	RNA polymerase activity
AI20_20905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AI20_20910	COG2964	Protein conserved in bacteria
AI20_20915	COG0251	oxidation-reduction process
AI20_20930	COG2168	tRNA wobble position uridine thiolation
AI20_20940	COG0049	tRNA binding
AI20_20945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AI20_20950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AI20_20955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AI20_20990	COG2252	PERMEase
AI20_20995	COG2376	Dihydroxyacetone kinase
AI20_21000	COG1461	Dihydroxyacetone kinase
AI20_21015	COG3284	Transcriptional regulator
AI20_21025	COG2957	Belongs to the agmatine deiminase family
AI20_21030	COG4221	oxidoreductase activity
AI20_21035	COG0628	permease
AI20_21065	COG1247	-acetyltransferase
AI20_21085	COG3706	GGDEF domain
AI20_21095	COG3842	ATPase activity
AI20_21105	COG1175	transmembrane transport
AI20_21130	COG0583	DNA-binding transcription factor activity
AI20_21140	COG1741	Belongs to the pirin family
AI20_21145	COG2259	Doxx family
AI20_21150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AI20_21155	COG1074	ATP-dependent DNA helicase activity
AI20_21160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AI20_21165	COG0583	DNA-binding transcription factor activity
AI20_21175	COG0346	lactoylglutathione lyase activity
AI20_21185	COG0745	RESPONSE REGULATOR receiver
AI20_21185	COG3706	GGDEF domain
AI20_21210	COG0745	RESPONSE REGULATOR receiver
AI20_21220	COG4251	negative regulation of phosphorylation
AI20_21220	COG2203	Gaf domain
AI20_21220	COG5001	Diguanylate cyclase
AI20_21220	COG3706	GGDEF domain
AI20_21225	COG4771	TonB-dependent receptor
AI20_21230	COG1278	Cold shock
AI20_21285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AI20_21305	COG2197	response regulator
AI20_21310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AI20_21315	COG3706	GGDEF domain
AI20_21325	COG3047	cAMP biosynthetic process
AI20_21330	COG0840	transmembrane signaling receptor activity
AI20_21360	COG3135	benzoate transporter
AI20_21365	COG1396	sequence-specific DNA binding
AI20_21395	COG2926	Belongs to the UPF0265 family
AI20_21405	COG3028	Belongs to the UPF0307 family
AI20_21410	COG0312	modulator of DNA gyrase
AI20_21415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AI20_21420	COG5007	Belongs to the BolA IbaG family
AI20_21430	COG2854	intermembrane phospholipid transfer
AI20_21435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AI20_21440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AI20_21445	COG1127	ABC transporter
AI20_21450	COG0517	IMP dehydrogenase activity
AI20_21450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AI20_21455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AI20_21460	COG3117	lipopolysaccharide transmembrane transporter activity
AI20_21465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AI20_21470	COG1137	ATPase activity
AI20_21475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AI20_21485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_21490	COG1660	Displays ATPase and GTPase activities
AI20_21495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_21500	COG3711	transcriptional antiterminator
AI20_21500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_21515	COG3964	amidohydrolase
AI20_21545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AI20_21550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AI20_21560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AI20_21565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AI20_21570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AI20_21575	COG0723	plastoquinol--plastocyanin reductase activity
AI20_21580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AI20_21585	COG2857	Cytochrome c1
AI20_21590	COG0625	glutathione transferase activity
AI20_21595	COG2969	positive regulation of protein catabolic process
AI20_21600	COG2823	Periplasmic or secreted lipoprotein
AI20_21605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AI20_21610	COG0792	nuclease activity
AI20_21615	COG3107	peptidoglycan biosynthetic process
AI20_21620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AI20_21625	COG2001	Belongs to the MraZ family
AI20_21630	COG0275	rRNA processing
AI20_21635	COG3116	cell division
AI20_21640	COG0768	penicillin binding
AI20_21650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AI20_21660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AI20_21665	COG0772	Belongs to the SEDS family
AI20_21670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AI20_21675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AI20_21680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AI20_21685	COG0849	cell division
AI20_21690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AI20_21695	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AI20_21705	COG0653	protein targeting
AI20_21715	COG0494	nUDIX hydrolase
AI20_21720	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AI20_21725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AI20_21740	COG1459	type II secretion system
AI20_21745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_21770	COG2186	Transcriptional regulator
AI20_21775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AI20_21780	COG0508	dehydrogenase complex catalyzes the overall conversion of
AI20_21785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AI20_21795	COG0840	transmembrane signaling receptor activity
AI20_21800	COG0840	transmembrane signaling receptor activity
AI20_21805	COG1752	Esterase of the alpha-beta hydrolase superfamily
AI20_21810	COG1049	propionate catabolic process, 2-methylcitrate cycle
AI20_21815	COG2200	EAL domain
AI20_21825	COG1280	lysine exporter protein (LysE YggA)
AI20_21835	COG0523	cobalamin synthesis protein
AI20_21840	COG0477	Major facilitator Superfamily
AI20_21855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AI20_21860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AI20_21950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_22030	COG0835	chemotaxis
AI20_22030	COG0784	Response regulator, receiver
AI20_22135	COG3179	chitinase
AI20_22140	COG3088	subunit of a heme lyase
AI20_22140	COG4235	cytochrome complex assembly