locus-tag	class	description
AHA_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AHA_0002	COG0592	DNA-directed DNA polymerase activity
AHA_0004	COG0187	DNA topoisomerase II activity
AHA_0006	COG2378	regulation of single-species biofilm formation
AHA_0007	COG0071	Belongs to the small heat shock protein (HSP20) family
AHA_0008	COG0071	Belongs to the small heat shock protein (HSP20) family
AHA_0009	COG3977	Valine--pyruvate aminotransferase
AHA_0012	COG2814	Major facilitator Superfamily
AHA_0013	COG0745	RESPONSE REGULATOR receiver
AHA_0014	COG2205	protein histidine kinase activity
AHA_0019	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHA_0020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_0020	COG4191	Histidine kinase
AHA_0021	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_0022	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_0023	COG1309	transcriptional regulator
AHA_0029	COG0469	pyruvate kinase activity
AHA_0030	COG2271	Major facilitator Superfamily
AHA_0035	COG0561	phosphatase activity
AHA_0036	COG2267	carboxylic ester hydrolase activity
AHA_0038	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHA_0039	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHA_0040	COG1758	RNA polymerase activity
AHA_0042	COG0859	PFAM glycosyl transferase family 9
AHA_0043	COG3642	lipopolysaccharide core region biosynthetic process
AHA_0051	COG0589	response to stress
AHA_0052	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AHA_0053	COG3706	GGDEF domain
AHA_0054	COG1528	Iron-storage protein
AHA_0055	COG2081	HI0933 family
AHA_0056	COG2223	nitrite transmembrane transporter activity
AHA_0060	COG3188	usher protein
AHA_0064	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_0064	COG2205	protein histidine kinase activity
AHA_0066	COG3275	phosphorelay sensor kinase activity
AHA_0067	COG3279	Response regulator of the LytR AlgR family
AHA_0068	COG2223	nitrite transmembrane transporter activity
AHA_0069	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AHA_0070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AHA_0073	COG0583	DNA-binding transcription factor activity
AHA_0074	COG4206	TonB-dependent receptor
AHA_0075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AHA_0082	COG0402	S-adenosylhomocysteine deaminase activity
AHA_0083	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AHA_0085	COG3165	ubiquinone biosynthetic process from chorismate
AHA_0086	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AHA_0088	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AHA_0089	COG0805	protein transport
AHA_0090	COG0084	hydrolase, TatD family'
AHA_0094	COG0742	ribosomal rna small subunit methyltransferase
AHA_0096	COG0248	Ppx GppA phosphatase
AHA_0097	COG0513	Belongs to the DEAD box helicase family
AHA_0098	COG3118	belongs to the thioredoxin family
AHA_0099	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AHA_0101	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AHA_0106	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHA_0112	COG0559	Belongs to the binding-protein-dependent transport system permease family
AHA_0114	COG1609	Transcriptional regulator
AHA_0117	COG2188	Transcriptional regulator
AHA_0118	COG3604	Transcriptional regulator
AHA_0119	COG0426	domain, Protein
AHA_0119	COG1773	rubredoxin
AHA_0120	COG0446	pyridine nucleotide-disulphide oxidoreductase
AHA_0122	COG0348	domain, Protein
AHA_0123	COG0814	amino acid
AHA_0127	COG0751	glycine-tRNA ligase activity
AHA_0128	COG0752	glycyl-tRNA synthetase alpha subunit
AHA_0129	COG2818	Glycosylase
AHA_0131	COG2885	chlorophyll binding
AHA_0132	COG0251	oxidation-reduction process
AHA_0133	COG0425	Belongs to the sulfur carrier protein TusA family
AHA_0136	COG2205	protein histidine kinase activity
AHA_0137	COG0745	RESPONSE REGULATOR receiver
AHA_0138	COG0183	Belongs to the thiolase family
AHA_0139	COG1024	Enoyl-CoA hydratase
AHA_0139	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHA_0140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHA_0141	COG0006	proline dipeptidase activity
AHA_0142	COG1739	Uncharacterized protein family UPF0029
AHA_0143	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHA_0144	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AHA_0149	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHA_0149	COG1042	CoA-binding domain protein
AHA_0149	COG0045	succinate-CoA ligase (ADP-forming) activity
AHA_0151	COG0583	DNA-binding transcription factor activity
AHA_0153	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AHA_0154	COG0166	Belongs to the GPI family
AHA_0156	COG0668	transmembrane transport
AHA_0157	COG1309	transcriptional regulator
AHA_0158	COG0756	dUTP diphosphatase activity
AHA_0159	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AHA_0160	COG2003	Belongs to the UPF0758 family
AHA_0161	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AHA_0162	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AHA_0164	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AHA_0165	COG2990	Protein conserved in bacteria
AHA_0166	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AHA_0167	COG0859	PFAM glycosyl transferase family 9
AHA_0168	COG0463	Glycosyl transferase, family 2
AHA_0169	COG0859	PFAM glycosyl transferase family 9
AHA_0170	COG1519	Transferase
AHA_0174	COG1609	Transcriptional regulator
AHA_0175	COG0604	alcohol dehydrogenase
AHA_0179	COG1580	Controls the rotational direction of flagella during chemotaxis
AHA_0180	COG3161	chorismate lyase activity
AHA_0181	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AHA_0182	COG2937	Belongs to the GPAT DAPAT family
AHA_0183	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AHA_0187	COG0534	Mate efflux family protein
AHA_0188	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AHA_0189	COG2205	protein histidine kinase activity
AHA_0190	COG0745	RESPONSE REGULATOR receiver
AHA_0192	COG1045	serine acetyltransferase
AHA_0194	COG3074	FtsZ-dependent cytokinesis
AHA_0195	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AHA_0196	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHA_0196	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHA_0197	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AHA_0204	COG1609	Transcriptional regulator
AHA_0205	COG3250	beta-galactosidase activity
AHA_0206	COG2731	YhcH YjgK YiaL family protein
AHA_0207	COG0531	amino acid
AHA_0208	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHA_0209	COG0531	amino acid
AHA_0210	COG0385	Bile acid
AHA_0211	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AHA_0215	COG0583	DNA-binding transcription factor activity
AHA_0220	COG0210	DNA helicase
AHA_0234	COG1280	lysine exporter protein (LysE YggA)
AHA_0236	COG2391	methyltransferase activity
AHA_0237	COG0840	transmembrane signaling receptor activity
AHA_0239	COG1280	lysine exporter protein (LysE YggA)
AHA_0241	COG2962	Rard protein
AHA_0243	COG1012	belongs to the aldehyde dehydrogenase family
AHA_0244	COG1396	sequence-specific DNA binding
AHA_0247	COG0519	Catalyzes the synthesis of GMP from XMP
AHA_0247	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AHA_0248	COG0686	Belongs to the AlaDH PNT family
AHA_0249	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHA_0253	COG1322	Protein conserved in bacteria
AHA_0254	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHA_0255	COG0569	domain protein
AHA_0256	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AHA_0256	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AHA_0257	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHA_0258	COG0242	peptide deformylase activity
AHA_0260	COG0758	DNA mediated transformation
AHA_0261	COG2922	Belongs to the Smg family
AHA_0262	COG0551	DNA topoisomerase type I activity
AHA_0264	COG0009	L-threonylcarbamoyladenylate synthase
AHA_0265	COG0408	coproporphyrinogen oxidase activity
AHA_0266	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AHA_0268	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AHA_0270	COG3078	GTPase activator activity
AHA_0272	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AHA_0273	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHA_0274	COG2204	response regulator
AHA_0275	COG3852	Histidine kinase
AHA_0277	COG0174	glutamine synthetase
AHA_0279	COG1295	ribonuclease BN
AHA_0281	COG1490	D-aminoacyl-tRNA deacylase activity
AHA_0282	COG0456	acetyltransferase
AHA_0284	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AHA_0285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHA_0286	COG2610	gluconate transmembrane transporter activity
AHA_0287	COG3265	gluconokinase activity
AHA_0289	COG0800	Aldolase
AHA_0290	COG1609	Transcriptional regulator
AHA_0292	COG4942	peptidase
AHA_0293	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AHA_0294	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHA_0295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AHA_0296	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AHA_0297	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AHA_0297	COG0316	Belongs to the HesB IscA family
AHA_0298	COG1040	competence protein
AHA_0299	COG0596	Alpha beta hydrolase
AHA_0303	COG2183	response to ionizing radiation
AHA_0304	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AHA_0305	COG0745	RESPONSE REGULATOR receiver
AHA_0308	COG0051	transcription antitermination factor activity, RNA binding
AHA_0309	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AHA_0310	COG0088	Forms part of the polypeptide exit tunnel
AHA_0311	COG0089	rRNA binding
AHA_0312	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AHA_0313	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AHA_0314	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AHA_0315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AHA_0316	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AHA_0317	COG0255	Belongs to the universal ribosomal protein uL29 family
AHA_0318	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AHA_0319	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AHA_0320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AHA_0321	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AHA_0322	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AHA_0323	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AHA_0324	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AHA_0325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AHA_0326	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AHA_0327	COG1841	ribosomal large subunit assembly
AHA_0328	COG0200	Binds to the 23S rRNA
AHA_0329	COG0201	protein transport
AHA_0330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AHA_0331	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AHA_0332	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AHA_0333	COG0202	RNA polymerase activity
AHA_0334	COG0203	ribosomal protein L17
AHA_0343	COG2249	NAD(P)H dehydrogenase (quinone) activity
AHA_0344	COG0583	DNA-binding transcription factor activity
AHA_0345	COG4221	oxidoreductase activity
AHA_0348	COG1770	oligopeptidase
AHA_0353	COG3714	YhhN family
AHA_0358	COG1301	dicarboxylic acid transport
AHA_0360	COG2095	MarC family integral membrane protein
AHA_0364	COG0741	lytic transglycosylase activity
AHA_0365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHA_0370	COG0742	ribosomal rna small subunit methyltransferase
AHA_0371	COG0552	protein localization to endoplasmic reticulum
AHA_0372	COG2884	Cell division ATP-binding protein ftsE
AHA_0373	COG2177	Part of the ABC transporter FtsEX involved in
AHA_0375	COG0288	reversible hydration of carbon dioxide
AHA_0376	COG2188	Transcriptional regulator
AHA_0377	COG1228	amidohydrolase
AHA_0378	COG0010	Belongs to the arginase family
AHA_0379	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AHA_0380	COG2986	histidine ammonia-lyase
AHA_0381	COG0387	Pfam Sodium calcium exchanger
AHA_0382	COG2200	EAL domain
AHA_0383	COG2199	diguanylate cyclase activity
AHA_0383	COG2200	EAL domain
AHA_0392	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AHA_0393	COG1459	type II secretion system
AHA_0396	COG4968	Prepilin-type N-terminal cleavage methylation domain
AHA_0400	COG1077	Cell shape determining protein MreB Mrl
AHA_0401	COG1792	Involved in formation and maintenance of cell shape
AHA_0402	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AHA_0403	COG0424	maF-like protein
AHA_0404	COG1530	ribonuclease E activity
AHA_0405	COG3164	Protein of unknown function
AHA_0407	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AHA_0408	COG0312	modulator of DNA gyrase
AHA_0412	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_0412	COG1263	PTS System
AHA_0413	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AHA_0416	COG0477	Major facilitator Superfamily
AHA_0417	COG3437	response regulator, receiver
AHA_0419	COG2205	protein histidine kinase activity
AHA_0419	COG5002	protein histidine kinase activity
AHA_0419	COG0784	Response regulator, receiver
AHA_0420	COG2172	sigma factor antagonist activity
AHA_0421	COG1366	Belongs to the anti-sigma-factor antagonist family
AHA_0425	COG3700	Belongs to the class B bacterial acid phosphatase family
AHA_0426	COG2321	neutral zinc metallopeptidase
AHA_0428	COG1639	'signal transduction protein
AHA_0433	COG0189	ligase activity
AHA_0434	COG1114	Component of the transport system for branched-chain amino acids
AHA_0436	COG0745	RESPONSE REGULATOR receiver
AHA_0439	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AHA_0440	COG0352	thiamine-phosphate diphosphorylase activity
AHA_0441	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AHA_0443	COG2022	thiamine diphosphate biosynthetic process
AHA_0444	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AHA_0447	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AHA_0450	COG3706	GGDEF domain
AHA_0451	COG0814	amino acid
AHA_0452	COG3932	Exopolysaccharide synthesis, ExoD
AHA_0457	COG1733	regulation of RNA biosynthetic process
AHA_0464	COG1494	fructose-1,6-bisphosphatase
AHA_0467	COG2959	enzyme of heme biosynthesis
AHA_0469	COG0181	hydroxymethylbilane synthase activity
AHA_0470	COG3072	Adenylate cyclase
AHA_0471	COG0400	carboxylic ester hydrolase activity
AHA_0472	COG1965	Belongs to the frataxin family
AHA_0473	COG0019	diaminopimelate decarboxylase activity
AHA_0474	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AHA_0477	COG1011	Hydrolase
AHA_0481	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AHA_0482	COG0561	phosphatase activity
AHA_0485	COG1129	ABC transporter
AHA_0485	COG0842	Transport permease protein
AHA_0487	COG1546	Belongs to the CinA family
AHA_0487	COG1058	Belongs to the CinA family
AHA_0488	COG1418	mRNA catabolic process
AHA_0489	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AHA_0491	COG1522	sequence-specific DNA binding
AHA_0492	COG1368	sulfuric ester hydrolase activity
AHA_0496	COG1285	pathogenesis
AHA_0500	COG4221	oxidoreductase activity
AHA_0504	COG1979	alcohol dehydrogenase
AHA_0506	COG2873	o-acetylhomoserine
AHA_0511	COG5380	lipid catabolic process
AHA_0512	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AHA_0516	COG2949	membrane
AHA_0517	COG3291	Pkd domain containing protein
AHA_0519	COG3539	Fimbrial protein
AHA_0521	COG3188	usher protein
AHA_0523	COG3539	Fimbrial protein
AHA_0527	COG0318	PFAM AMP-dependent synthetase and ligase
AHA_0528	COG1441	menaquinone biosynthetic process
AHA_0529	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AHA_0530	COG0596	Alpha beta hydrolase
AHA_0531	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AHA_0532	COG1169	isochorismate synthase
AHA_0533	COG1575	Belongs to the MenA family. Type 1 subfamily
AHA_0538	COG0513	Belongs to the DEAD box helicase family
AHA_0539	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AHA_0540	COG1988	membrane-bound metal-dependent
AHA_0543	COG1671	Belongs to the UPF0178 family
AHA_0548	COG3263	regulation of cellular component size
AHA_0549	COG3722	fumarate hydratase activity
AHA_0550	COG0246	Mannitol dehydrogenase
AHA_0551	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_0551	COG2213	PTS system mannitol-specific
AHA_0553	COG1309	transcriptional regulator
AHA_0554	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AHA_0556	COG3916	Acyl-homoserine-lactone synthase
AHA_0557	COG2771	luxR family
AHA_0560	COG3133	Outer membrane lipoprotein
AHA_0561	COG0456	acetyltransferase
AHA_0566	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AHA_0568	COG3031	protein transport across the cell outer membrane
AHA_0570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AHA_0571	COG1459	type II secretion system
AHA_0572	COG2165	general secretion pathway protein
AHA_0574	COG2165	general secretion pathway protein
AHA_0575	COG4795	General secretion pathway protein
AHA_0576	COG3156	type II secretion system protein K
AHA_0578	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AHA_0581	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AHA_0582	COG1011	Hydrolase
AHA_0583	COG0494	nUDIX hydrolase
AHA_0584	COG1218	3'(2'),5'-bisphosphate nucleotidase
AHA_0585	COG0814	amino acid
AHA_0586	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHA_0587	COG3708	Transcriptional regulator
AHA_0587	COG2207	Transcriptional regulator
AHA_0589	COG0626	cystathionine gamma-synthase activity
AHA_0590	COG0460	homoserine dehydrogenase
AHA_0590	COG0527	aspartate kinase activity
AHA_0591	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AHA_0593	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AHA_0594	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AHA_0596	COG0137	argininosuccinate synthase activity
AHA_0597	COG0165	Argininosuccinate lyase
AHA_0598	COG2856	Zn peptidase
AHA_0602	COG0110	maltose O-acetyltransferase activity
AHA_0603	COG3174	membrane
AHA_0604	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AHA_0606	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AHA_0607	COG4208	sulfate ABC transporter
AHA_0608	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AHA_0609	COG0583	DNA-binding transcription factor activity
AHA_0610	COG3397	chitin binding
AHA_0611	COG0840	transmembrane signaling receptor activity
AHA_0617	COG4946	Tricorn protease homolog
AHA_0617	COG0793	Belongs to the peptidase S41A family
AHA_0620	COG1328	CTP reductase activity
AHA_0621	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AHA_0624	COG1448	Aminotransferase
AHA_0632	COG0513	Belongs to the DEAD box helicase family
AHA_0635	COG3568	Endonuclease Exonuclease Phosphatase
AHA_0636	COG0840	transmembrane signaling receptor activity
AHA_0639	COG3112	Uncharacterised protein family (UPF0231)
AHA_0640	COG3835	regulator
AHA_0641	COG2610	gluconate transmembrane transporter activity
AHA_0642	COG1929	Belongs to the glycerate kinase type-1 family
AHA_0645	COG0583	DNA-binding transcription factor activity
AHA_0646	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AHA_0649	COG0347	Belongs to the P(II) protein family
AHA_0650	COG1840	ABC-type Fe3 transport system, periplasmic component
AHA_0652	COG3842	ATPase activity
AHA_0653	COG2837	iron assimilation
AHA_0654	COG1438	arginine binding
AHA_0655	COG1126	abc transporter atp-binding protein
AHA_0656	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_0657	COG4215	(ABC) transporter
AHA_0658	COG4160	amino acid transport
AHA_0659	COG0039	L-malate dehydrogenase activity
AHA_0660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AHA_0661	COG1017	nitric oxide dioxygenase activity
AHA_0661	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHA_0663	COG4536	flavin adenine dinucleotide binding
AHA_0664	COG4137	Cytochrome C assembly protein
AHA_0665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AHA_0666	COG0228	four-way junction DNA binding
AHA_0667	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AHA_0668	COG0336	Belongs to the RNA methyltransferase TrmD family
AHA_0669	COG0335	large ribosomal subunit rRNA binding
AHA_0671	COG3066	DNA modification
AHA_0672	COG1051	belongs to the nudix hydrolase family
AHA_0674	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AHA_0675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AHA_0676	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHA_0677	COG0583	DNA-binding transcription factor activity
AHA_0678	COG0640	Transcriptional regulator
AHA_0679	COG0268	Binds directly to 16S ribosomal RNA
AHA_0680	COG0728	peptidoglycan biosynthetic process
AHA_0681	COG0196	riboflavin kinase activity
AHA_0682	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AHA_0683	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AHA_0684	COG1047	Peptidyl-prolyl cis-trans
AHA_0685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AHA_0697	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AHA_0697	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AHA_0700	COG1854	S-ribosylhomocysteine lyase activity
AHA_0701	COG3706	GGDEF domain
AHA_0702	COG0557	exoribonuclease II activity
AHA_0703	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AHA_0705	COG2153	protein acetylation
AHA_0709	COG1914	H( )-stimulated, divalent metal cation uptake system
AHA_0710	COG0360	Binds together with S18 to 16S ribosomal RNA
AHA_0711	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AHA_0712	COG0359	binds to the 23S rRNA
AHA_0713	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHA_0718	COG1238	metal cluster binding
AHA_0719	COG0612	Peptidase, M16
AHA_0720	COG2918	glutathione biosynthetic process
AHA_0722	COG1022	Amp-dependent synthetase and ligase
AHA_0724	COG0456	acetyltransferase
AHA_0725	COG0714	Associated with various cellular activities
AHA_0726	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AHA_0727	COG5001	Diguanylate cyclase
AHA_0727	COG3300	MHYT domain
AHA_0729	COG0745	RESPONSE REGULATOR receiver
AHA_0729	COG3706	GGDEF domain
AHA_0735	COG1902	pentaerythritol trinitrate reductase activity
AHA_0738	COG2957	Belongs to the agmatine deiminase family
AHA_0739	COG0154	amidase activity
AHA_0742	COG0513	Belongs to the DEAD box helicase family
AHA_0746	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AHA_0751	COG2070	2-Nitropropane dioxygenase
AHA_0758	COG2205	protein histidine kinase activity
AHA_0759	COG0745	RESPONSE REGULATOR receiver
AHA_0760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_0761	COG0577	efflux transmembrane transporter activity
AHA_0761	COG1136	(ABC) transporter
AHA_0762	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_0763	COG1126	abc transporter atp-binding protein
AHA_0764	COG0765	amino acid transport
AHA_0765	COG0765	amino acid transport
AHA_0766	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AHA_0767	COG1505	serine-type exopeptidase activity
AHA_0770	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_0771	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AHA_0774	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHA_0775	COG4991	sh3 domain protein
AHA_0777	COG2816	NAD+ diphosphatase activity
AHA_0778	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AHA_0779	COG1940	carbohydrate kinase activity
AHA_0780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AHA_0781	COG0126	phosphoglycerate kinase activity
AHA_0783	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHA_0791	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AHA_0793	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AHA_0794	COG1595	DNA-templated transcription, initiation
AHA_0795	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AHA_0798	COG0481	GTPase activity
AHA_0799	COG0681	Belongs to the peptidase S26 family
AHA_0800	COG0571	ribonuclease III activity
AHA_0802	COG1381	Involved in DNA repair and RecF pathway recombination
AHA_0803	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AHA_0806	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AHA_0807	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_0808	COG3716	PTS system mannose fructose sorbose family IID component
AHA_0810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_0811	COG2222	sugar isomerase
AHA_0813	COG1349	DNA-binding transcription factor activity
AHA_0814	COG3023	N-Acetylmuramoyl-L-alanine amidase
AHA_0815	COG4807	Protein conserved in bacteria
AHA_0817	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHA_0818	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AHA_0819	COG3956	TIGRFAM MazG family protein
AHA_0820	COG0504	CTP synthase activity
AHA_0821	COG0148	phosphopyruvate hydratase activity
AHA_0822	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AHA_0823	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AHA_0825	COG0585	pseudouridine synthase activity
AHA_0826	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AHA_0827	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AHA_0828	COG1238	metal cluster binding
AHA_0829	COG4942	peptidase
AHA_0829	COG1388	LysM domain
AHA_0831	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AHA_0832	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AHA_0833	COG1610	YqeY-like protein
AHA_0834	COG0358	DNA primase activity
AHA_0835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AHA_0840	COG0151	Belongs to the GarS family
AHA_0841	COG0138	bifunctional purine biosynthesis protein purh
AHA_0843	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AHA_0844	COG3036	rescue of stalled ribosome
AHA_0845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AHA_0846	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AHA_0848	COG0673	inositol 2-dehydrogenase activity
AHA_0849	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHA_0853	COG0477	Major facilitator Superfamily
AHA_0855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AHA_0856	COG1027	Aspartate ammonia-lyase
AHA_0857	COG3030	protein affecting phage T7 exclusion by the F plasmid
AHA_0858	COG0534	Mate efflux family protein
AHA_0859	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AHA_0860	COG0459	protein refolding
AHA_0862	COG5001	Diguanylate cyclase
AHA_0862	COG3300	MHYT domain
AHA_0863	COG0564	pseudouridine synthase activity
AHA_0864	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AHA_0870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHA_0872	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AHA_0874	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AHA_0875	COG1178	ABC-type Fe3 transport system permease component
AHA_0876	COG4143	(ABC) transporter
AHA_0879	COG0066	3-isopropylmalate dehydratase activity
AHA_0880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AHA_0881	COG0473	3-isopropylmalate dehydrogenase activity
AHA_0882	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHA_0884	COG0671	phosphoesterase, PA-phosphatase related
AHA_0885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AHA_0887	COG0028	Belongs to the TPP enzyme family
AHA_0890	COG0280	phosphate acetyltransferase
AHA_0890	COG0857	belongs to the CobB CobQ family
AHA_0891	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AHA_0892	COG3092	negative regulation of chromosome organization
AHA_0893	COG3013	Belongs to the UPF0304 family
AHA_0894	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AHA_0895	COG2716	regulation of RNA biosynthetic process
AHA_0897	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AHA_0898	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AHA_0901	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AHA_0905	COG2198	Histidine kinase
AHA_0905	COG5002	protein histidine kinase activity
AHA_0905	COG0784	Response regulator, receiver
AHA_0910	COG0840	transmembrane signaling receptor activity
AHA_0913	COG1464	Belongs to the NlpA lipoprotein family
AHA_0914	COG2011	ABC-type metal ion transport system permease component
AHA_0915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AHA_0918	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AHA_0919	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AHA_0919	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AHA_0920	COG0802	atpase or kinase
AHA_0922	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AHA_0923	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AHA_0924	COG1923	regulation of RNA biosynthetic process
AHA_0925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AHA_0926	COG0330	HflC and HflK could
AHA_0927	COG0330	HflC and HflK could
AHA_0928	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AHA_0929	COG0142	geranyltranstransferase activity
AHA_0930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AHA_0931	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AHA_0932	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AHA_0937	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AHA_0938	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AHA_0940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AHA_0942	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AHA_0943	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AHA_0945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AHA_0946	COG3178	'Phosphotransferase
AHA_0947	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AHA_0948	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AHA_0949	COG2252	PERMEase
AHA_0950	COG0488	(ABC) transporter
AHA_0953	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AHA_0954	COG0741	lytic transglycosylase activity
AHA_0958	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AHA_0959	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AHA_0960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AHA_0965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHA_0967	COG3721	Heme iron utilization protein
AHA_0968	COG0748	coenzyme F420 binding
AHA_0972	COG4771	TonB-dependent receptor
AHA_0973	COG2814	Major facilitator Superfamily
AHA_0974	COG3655	Transcriptional regulator
AHA_0976	COG2205	protein histidine kinase activity
AHA_0976	COG2202	Pas domain
AHA_0979	COG3397	chitin binding
AHA_0980	COG2226	methyltransferase
AHA_0981	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHA_0982	COG1765	OsmC-like protein
AHA_0985	COG3954	Phosphoribulokinase
AHA_0986	COG2076	Multidrug Resistance protein
AHA_0987	COG2076	Multidrug Resistance protein
AHA_0988	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AHA_0989	COG0726	polysaccharide deacetylase
AHA_0990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHA_0990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHA_0991	COG0463	Glycosyl transferase, family 2
AHA_0992	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AHA_0994	COG3089	Belongs to the UPF0270 family
AHA_0995	COG0429	hydrolase of the alpha beta-hydrolase fold
AHA_0996	COG4251	negative regulation of phosphorylation
AHA_0996	COG2203	Gaf domain
AHA_0996	COG3706	GGDEF domain
AHA_0996	COG5001	Diguanylate cyclase
AHA_0997	COG0835	chemotaxis
AHA_0997	COG0784	Response regulator, receiver
AHA_0999	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AHA_1000	COG1047	Peptidyl-prolyl cis-trans
AHA_1001	COG2900	Belongs to the SlyX family
AHA_1003	COG0545	Peptidyl-prolyl cis-trans isomerase
AHA_1004	COG2204	response regulator
AHA_1008	COG0737	Belongs to the 5'-nucleotidase family
AHA_1009	COG2200	EAL domain
AHA_1012	COG0305	Participates in initiation and elongation during chromosome replication
AHA_1013	COG0305	Participates in initiation and elongation during chromosome replication
AHA_1014	COG0305	Participates in initiation and elongation during chromosome replication
AHA_1015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHA_1016	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_1018	COG2203	Gaf domain
AHA_1018	COG2200	EAL domain
AHA_1018	COG2199	diguanylate cyclase activity
AHA_1021	COG3188	usher protein
AHA_1023	COG2197	response regulator
AHA_1029	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHA_1030	COG2201	protein-glutamate methylesterase activity
AHA_1031	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AHA_1033	COG0840	transmembrane signaling receptor activity
AHA_1034	COG0835	chemotaxis
AHA_1036	COG2198	Histidine kinase
AHA_1036	COG0643	Histidine kinase
AHA_1038	COG0745	RESPONSE REGULATOR receiver
AHA_1039	COG0840	transmembrane signaling receptor activity
AHA_1042	COG1280	lysine exporter protein (LysE YggA)
AHA_1043	COG0826	peptidase U32
AHA_1048	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AHA_1052	COG0300	oxidoreductase activity
AHA_1054	COG0840	transmembrane signaling receptor activity
AHA_1056	COG2610	gluconate transmembrane transporter activity
AHA_1057	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHA_1058	COG3622	Belongs to the hyi family
AHA_1059	COG0235	Class ii aldolase
AHA_1061	COG2084	Dehydrogenase
AHA_1062	COG1349	DNA-binding transcription factor activity
AHA_1064	COG2373	Large extracellular alpha-helical protein
AHA_1064	COG4932	domain protein
AHA_1064	COG1388	LysM domain
AHA_1068	COG5001	Diguanylate cyclase
AHA_1070	COG3710	Transcriptional regulator
AHA_1072	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AHA_1079	COG2003	Belongs to the UPF0758 family
AHA_1086	COG5377	YqaJ viral recombinase family
AHA_1092	COG1605	Chorismate mutase
AHA_1092	COG0077	Prephenate dehydratase
AHA_1099	COG3272	Protein of unknown function (DUF1722)
AHA_1100	COG0789	Transcriptional regulator
AHA_1101	COG0415	Belongs to the DNA photolyase family
AHA_1103	COG4221	oxidoreductase activity
AHA_1106	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AHA_1110	COG0783	Belongs to the Dps family
AHA_1111	COG1151	hydroxylamine reductase activity
AHA_1113	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AHA_1114	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHA_1114	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AHA_1117	COG2771	luxR family
AHA_1119	COG3501	Rhs element vgr protein
AHA_1127	COG0693	protein deglycase activity
AHA_1128	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AHA_1129	COG1666	GTP binding
AHA_1130	COG3248	Nucleoside-binding outer membrane protein
AHA_1132	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AHA_1134	COG2813	Specifically methylates the guanine in position
AHA_1135	COG0271	Belongs to the BolA IbaG family
AHA_1136	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AHA_1137	COG1805	sodium ion transport
AHA_1138	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AHA_1139	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AHA_1140	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AHA_1141	COG2871	sodium ion transport
AHA_1142	COG1477	protein flavinylation
AHA_1145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AHA_1146	COG0840	transmembrane signaling receptor activity
AHA_1147	COG0583	DNA-binding transcription factor activity
AHA_1149	COG2363	Small membrane protein
AHA_1150	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AHA_1152	COG0473	3-isopropylmalate dehydrogenase activity
AHA_1153	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AHA_1154	COG1611	Belongs to the LOG family
AHA_1155	COG3706	GGDEF domain
AHA_1157	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AHA_1157	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AHA_1159	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AHA_1163	COG3098	single-species biofilm formation
AHA_1164	COG0564	pseudouridine synthase activity
AHA_1166	COG4580	involved in the transport of maltose and maltodextrins
AHA_1168	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_1168	COG1263	PTS System
AHA_1170	COG2171	N-acyltransferase activity
AHA_1171	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AHA_1172	COG0024	Methionine aminopeptidase
AHA_1173	COG0052	Belongs to the universal ribosomal protein uS2 family
AHA_1174	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AHA_1175	COG0528	UMP kinase activity
AHA_1176	COG0233	cytoplasmic translational termination
AHA_1178	COG0575	Belongs to the CDS family
AHA_1179	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AHA_1180	COG0750	zinc metalloprotease
AHA_1183	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AHA_1184	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AHA_1185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AHA_1186	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AHA_1187	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AHA_1189	COG0825	malonyl-CoA metabolic process
AHA_1190	COG3710	Transcriptional regulator
AHA_1191	COG0531	amino acid
AHA_1192	COG1982	Orn Lys Arg decarboxylase major
AHA_1193	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AHA_1196	COG0814	amino acid
AHA_1199	COG1073	alpha beta
AHA_1200	COG1073	alpha beta
AHA_1202	COG0531	amino acid
AHA_1204	COG0488	(ABC) transporter
AHA_1206	COG3590	peptidase
AHA_1208	COG3706	GGDEF domain
AHA_1215	COG0366	Alpha amylase catalytic
AHA_1218	COG0463	Glycosyl transferase, family 2
AHA_1222	COG2989	Protein conserved in bacteria
AHA_1223	COG3108	Peptidase M15
AHA_1225	COG2860	membrane
AHA_1227	COG1196	nuclear chromosome segregation
AHA_1228	COG3115	cell septum assembly
AHA_1229	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AHA_1231	COG1328	CTP reductase activity
AHA_1232	COG0602	queuosine metabolic process
AHA_1239	COG1566	PFAM secretion protein HlyD family protein
AHA_1240	COG1846	Transcriptional regulator
AHA_1243	COG0281	malic enzyme
AHA_1244	COG3290	protein histidine kinase activity
AHA_1245	COG4565	transcriptional regulatory protein
AHA_1246	COG0697	spore germination
AHA_1248	COG1012	belongs to the aldehyde dehydrogenase family
AHA_1249	COG3284	Transcriptional regulator
AHA_1250	COG1960	acyl-CoA dehydrogenase activity
AHA_1251	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AHA_1252	COG0346	lactoylglutathione lyase activity
AHA_1253	COG0745	RESPONSE REGULATOR receiver
AHA_1254	COG5002	protein histidine kinase activity
AHA_1256	COG4783	chaperone-mediated protein folding
AHA_1259	COG3142	Participates in the control of copper homeostasis
AHA_1261	COG0545	Peptidyl-prolyl cis-trans isomerase
AHA_1262	COG1131	(ABC) transporter
AHA_1266	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AHA_1268	COG0678	peroxiredoxin activity
AHA_1270	COG0019	diaminopimelate decarboxylase activity
AHA_1271	COG1115	amino acid carrier protein
AHA_1272	COG0095	Lipoate-protein ligase
AHA_1273	COG2233	PERMEase
AHA_1274	COG0745	RESPONSE REGULATOR receiver
AHA_1274	COG3706	GGDEF domain
AHA_1276	COG0534	Mate efflux family protein
AHA_1278	COG0281	malic enzyme
AHA_1284	COG0733	neurotransmitter:sodium symporter activity
AHA_1285	COG1752	Esterase of the alpha-beta hydrolase superfamily
AHA_1286	COG2199	diguanylate cyclase activity
AHA_1286	COG2203	Gaf domain
AHA_1287	COG1566	PFAM secretion protein HlyD family protein
AHA_1288	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_1290	COG1032	radical SAM domain protein
AHA_1295	COG3152	Membrane
AHA_1300	COG0673	inositol 2-dehydrogenase activity
AHA_1301	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AHA_1302	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHA_1303	COG0741	lytic transglycosylase activity
AHA_1303	COG1196	nuclear chromosome segregation
AHA_1303	COG0739	heme binding
AHA_1304	COG0366	Alpha amylase catalytic
AHA_1308	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AHA_1310	COG0788	formyltetrahydrofolate deformylase activity
AHA_1311	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHA_1312	COG3118	belongs to the thioredoxin family
AHA_1313	COG2091	lysine biosynthetic process via aminoadipic acid
AHA_1314	COG0791	NLP P60 protein
AHA_1315	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AHA_1318	COG1388	LysM domain
AHA_1318	COG1376	ErfK ybiS ycfS ynhG family protein
AHA_1320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_1321	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_1322	COG0745	RESPONSE REGULATOR receiver
AHA_1323	COG5002	protein histidine kinase activity
AHA_1327	COG4869	propanediol catabolic process
AHA_1328	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AHA_1329	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AHA_1330	COG1882	Formate acetyltransferase
AHA_1331	COG1012	belongs to the aldehyde dehydrogenase family
AHA_1331	COG1454	alcohol dehydrogenase
AHA_1333	COG1454	alcohol dehydrogenase
AHA_1333	COG1012	belongs to the aldehyde dehydrogenase family
AHA_1334	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AHA_1335	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AHA_1336	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AHA_1340	COG0583	DNA-binding transcription factor activity
AHA_1341	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AHA_1342	COG0243	molybdopterin cofactor binding
AHA_1344	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AHA_1346	COG1960	acyl-CoA dehydrogenase activity
AHA_1347	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_1349	COG0469	pyruvate kinase activity
AHA_1350	COG1737	Transcriptional regulator
AHA_1353	COG0745	RESPONSE REGULATOR receiver
AHA_1354	COG2274	protein secretion by the type I secretion system
AHA_1355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_1356	COG2274	protein secretion by the type I secretion system
AHA_1358	COG2994	toxin metabolic process
AHA_1359	COG1073	alpha beta
AHA_1359	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AHA_1359	COG3064	Membrane
AHA_1361	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHA_1364	COG1677	Flagellar hook-basal body complex protein FliE
AHA_1366	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AHA_1376	COG1987	bacterial-type flagellum assembly
AHA_1377	COG1684	flagellar biosynthetic protein fliR
AHA_1379	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AHA_1381	COG0455	bacterial-type flagellum organization
AHA_1384	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AHA_1385	COG0643	Histidine kinase
AHA_1385	COG2198	Histidine kinase
AHA_1386	COG2201	protein-glutamate methylesterase activity
AHA_1387	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AHA_1388	COG1360	Flagellar Motor Protein
AHA_1389	COG1192	Involved in chromosome partitioning
AHA_1391	COG0835	chemotaxis
AHA_1394	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AHA_1395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AHA_1396	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AHA_1397	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AHA_1398	COG1138	Cytochrome C-type biogenesis protein
AHA_1399	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHA_1400	COG4235	cytochrome complex assembly
AHA_1400	COG3088	subunit of a heme lyase
AHA_1401	COG3088	subunit of a heme lyase
AHA_1401	COG4235	cytochrome complex assembly
AHA_1404	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AHA_1405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AHA_1405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AHA_1408	COG0259	pyridoxamine-phosphate oxidase activity
AHA_1409	COG0625	glutathione transferase activity
AHA_1411	COG3153	acetyltransferase
AHA_1412	COG2850	peptidyl-arginine hydroxylation
AHA_1413	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AHA_1414	COG2915	High frequency lysogenization protein hflD homolog
AHA_1415	COG0482	sulfurtransferase activity
AHA_1417	COG1187	pseudouridine synthase activity
AHA_1419	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_1421	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_1421	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_1421	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_1422	COG0456	acetyltransferase
AHA_1424	COG0789	Transcriptional regulator
AHA_1426	COG1609	Transcriptional regulator
AHA_1427	COG1263	PTS System
AHA_1427	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_1428	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AHA_1431	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_1435	COG2207	Transcriptional regulator
AHA_1436	COG0538	isocitrate dehydrogenase activity
AHA_1438	COG3048	D-serine ammonia-lyase activity
AHA_1439	COG0583	DNA-binding transcription factor activity
AHA_1440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AHA_1443	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AHA_1444	COG2867	negative regulation of translational initiation
AHA_1446	COG0702	epimerase
AHA_1447	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AHA_1453	COG4964	Belongs to the GSP D family
AHA_1463	COG1454	alcohol dehydrogenase
AHA_1471	COG1280	lysine exporter protein (LysE YggA)
AHA_1473	COG3263	regulation of cellular component size
AHA_1475	COG3263	regulation of cellular component size
AHA_1477	COG1876	peptidase activity
AHA_1478	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHA_1479	COG1393	Belongs to the ArsC family
AHA_1480	COG0583	DNA-binding transcription factor activity
AHA_1482	COG3069	C4-dicarboxylate transmembrane transporter activity
AHA_1485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AHA_1486	COG0017	Asparaginyl-tRNA synthetase
AHA_1489	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AHA_1490	COG0156	8-amino-7-oxononanoate synthase activity
AHA_1491	COG1073	alpha beta
AHA_1491	COG2226	methyltransferase
AHA_1492	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AHA_1493	COG0501	Belongs to the peptidase M48B family
AHA_1495	COG3217	Mosc domain protein beta barrel domain protein
AHA_1495	COG0633	Ferredoxin
AHA_1495	COG3217	Mosc domain protein beta barrel domain protein
AHA_1495	COG0633	Ferredoxin
AHA_1497	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AHA_1497	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AHA_1497	COG1013	pyruvate-flavodoxin oxidoreductase activity
AHA_1497	COG0674	pyruvate-flavodoxin oxidoreductase activity
AHA_1500	COG0534	Mate efflux family protein
AHA_1508	COG1309	transcriptional regulator
AHA_1511	COG0791	NLP P60 protein
AHA_1513	COG0583	DNA-binding transcription factor activity
AHA_1514	COG0450	alkyl hydroperoxide reductase
AHA_1518	COG0500	methyltransferase
AHA_1519	COG4106	trans-aconitate 2-methyltransferase activity
AHA_1520	COG1801	Protein of unknown function DUF72
AHA_1521	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AHA_1522	COG0217	transcriptional regulatory protein
AHA_1523	COG2194	sulfuric ester hydrolase activity
AHA_1524	COG1940	carbohydrate kinase activity
AHA_1524	COG1846	Transcriptional regulator
AHA_1525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AHA_1526	COG0363	glucosamine-6-phosphate deaminase activity
AHA_1527	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_1527	COG1263	PTS System
AHA_1527	COG2190	(PTS) system
AHA_1529	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHA_1530	COG0735	belongs to the Fur family
AHA_1532	COG0716	FMN binding
AHA_1535	COG0596	Alpha beta hydrolase
AHA_1536	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AHA_1537	COG0033	Phosphoglucomutase
AHA_1539	COG1846	Transcriptional regulator
AHA_1542	COG2951	lytic endotransglycosylase activity
AHA_1543	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AHA_1544	COG4136	ATPase activity
AHA_1546	COG4134	Bacterial extracellular solute-binding protein
AHA_1548	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHA_1550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHA_1551	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AHA_1553	COG0729	surface antigen
AHA_1554	COG2911	Protein conserved in bacteria
AHA_1558	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AHA_1560	COG0741	lytic transglycosylase activity
AHA_1563	COG1607	acyl-coa hydrolase
AHA_1565	COG3021	interspecies interaction between organisms
AHA_1566	COG1388	LysM domain
AHA_1566	COG0741	lytic transglycosylase activity
AHA_1567	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHA_1568	COG0328	RNA-DNA hybrid ribonuclease activity
AHA_1569	COG2226	methyltransferase
AHA_1570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AHA_1572	COG3437	response regulator, receiver
AHA_1572	COG0784	Response regulator, receiver
AHA_1573	COG1960	acyl-CoA dehydrogenase activity
AHA_1574	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AHA_1575	COG0121	glutamine amidotransferase
AHA_1579	COG2205	protein histidine kinase activity
AHA_1579	COG0784	Response regulator, receiver
AHA_1581	COG2197	response regulator
AHA_1582	COG3850	Histidine kinase
AHA_1583	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AHA_1584	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_1584	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_1586	COG0243	molybdopterin cofactor binding
AHA_1587	COG0437	4 iron, 4 sulfur cluster binding
AHA_1588	COG0348	domain, Protein
AHA_1590	COG3005	denitrification pathway
AHA_1591	COG0521	Mo-molybdopterin cofactor biosynthetic process
AHA_1592	COG0315	cyclic pyranopterin monophosphate synthase activity
AHA_1593	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AHA_1594	COG0314	molybdopterin synthase activity
AHA_1597	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AHA_1598	COG2267	carboxylic ester hydrolase activity
AHA_1599	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AHA_1601	COG0302	gtp cyclohydrolase
AHA_1602	COG0840	transmembrane signaling receptor activity
AHA_1603	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHA_1604	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AHA_1606	COG0583	DNA-binding transcription factor activity
AHA_1612	COG2195	Cleaves the N-terminal amino acid of tripeptides
AHA_1613	COG1166	arginine decarboxylase activity
AHA_1617	COG0814	amino acid
AHA_1619	COG3681	Belongs to the UPF0597 family
AHA_1620	COG2964	Protein conserved in bacteria
AHA_1622	COG1403	HNH endonuclease
AHA_1624	COG0346	lactoylglutathione lyase activity
AHA_1628	COG1187	pseudouridine synthase activity
AHA_1629	COG2807	transmembrane transport
AHA_1631	COG0583	DNA-binding transcription factor activity
AHA_1632	COG2271	Major facilitator Superfamily
AHA_1637	COG2979	Protein of unknown function (DUF533)
AHA_1639	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHA_1640	COG1271	oxidase subunit
AHA_1641	COG1294	oxidase, subunit
AHA_1643	COG2814	Major facilitator Superfamily
AHA_1644	COG0656	L-ascorbic acid biosynthetic process
AHA_1647	COG0583	DNA-binding transcription factor activity
AHA_1648	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AHA_1649	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AHA_1650	COG2271	Major facilitator Superfamily
AHA_1651	COG1349	DNA-binding transcription factor activity
AHA_1653	COG0584	glycerophosphoryl diester phosphodiesterase
AHA_1654	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHA_1655	COG0287	Prephenate dehydrogenase
AHA_1655	COG1605	Chorismate mutase
AHA_1656	COG0583	DNA-binding transcription factor activity
AHA_1657	COG3085	chromosome segregation
AHA_1658	COG4574	serine-type endopeptidase inhibitor activity
AHA_1662	COG1770	oligopeptidase
AHA_1663	COG4771	TonB-dependent receptor
AHA_1664	COG3083	sulfuric ester hydrolase activity
AHA_1665	COG3082	Protein of unknown function (DUF1414)
AHA_1666	COG3081	Nucleoid-associated protein
AHA_1668	COG1175	transmembrane transport
AHA_1670	COG3842	ATPase activity
AHA_1675	COG0425	Belongs to the sulfur carrier protein TusA family
AHA_1676	COG4783	chaperone-mediated protein folding
AHA_1678	COG1393	Belongs to the ArsC family
AHA_1682	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AHA_1683	COG2431	L-lysine efflux transmembrane transporter activity
AHA_1685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_1686	COG4215	(ABC) transporter
AHA_1689	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AHA_1691	COG0446	pyridine nucleotide-disulphide oxidoreductase
AHA_1692	COG2373	Large extracellular alpha-helical protein
AHA_1693	COG4953	penicillin-binding protein 1C
AHA_1695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AHA_1695	COG0301	tRNA thio-modification
AHA_1698	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AHA_1699	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AHA_1706	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AHA_1710	COG0483	inositol monophosphate 1-phosphatase activity
AHA_1712	COG0625	glutathione transferase activity
AHA_1713	COG2814	Major facilitator Superfamily
AHA_1716	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHA_1717	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHA_1718	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AHA_1719	COG0509	glycine decarboxylation via glycine cleavage system
AHA_1720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHA_1720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AHA_1726	COG0798	PFAM Bile acid sodium symporter
AHA_1727	COG1393	Belongs to the ArsC family
AHA_1731	COG3634	alkyl hydroperoxide reductase activity
AHA_1732	COG0450	alkyl hydroperoxide reductase
AHA_1733	COG0517	IMP dehydrogenase activity
AHA_1734	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AHA_1735	COG0343	queuine tRNA-ribosyltransferase activity
AHA_1736	COG1862	Preprotein translocase
AHA_1737	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHA_1738	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHA_1747	COG1104	cysteine desulfurase activity
AHA_1748	COG0822	iron-sulfur transferase activity
AHA_1750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AHA_1751	COG0443	Heat shock 70 kDa protein
AHA_1752	COG0633	Ferredoxin
AHA_1754	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHA_1755	COG0105	UTP biosynthetic process
AHA_1756	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AHA_1759	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AHA_1760	COG0124	histidyl-tRNA synthetase
AHA_1761	COG2976	Protein conserved in bacteria
AHA_1762	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AHA_1763	COG1160	GTP binding
AHA_1764	COG1645	bacterial-type flagellum-dependent swarming motility
AHA_1765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AHA_1766	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AHA_1766	COG0047	phosphoribosylformylglycinamidine synthase activity
AHA_1767	COG2199	diguanylate cyclase activity
AHA_1767	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AHA_1770	COG1007	ATP synthesis coupled electron transport
AHA_1771	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_1773	COG0713	ATP synthesis coupled electron transport
AHA_1774	COG0839	Belongs to the complex I subunit 6 family
AHA_1775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_1776	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AHA_1777	COG1034	ATP synthesis coupled electron transport
AHA_1780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_1780	COG0649	NAD binding
AHA_1781	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_1782	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_1783	COG1360	Flagellar Motor Protein
AHA_1784	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AHA_1787	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AHA_1791	COG0724	RNA recognition motif
AHA_1792	COG4989	oxidoreductase activity
AHA_1797	COG3437	response regulator, receiver
AHA_1798	COG0583	DNA-binding transcription factor activity
AHA_1800	COG5001	Diguanylate cyclase
AHA_1800	COG3300	MHYT domain
AHA_1801	COG0778	Nitroreductase
AHA_1805	COG0583	DNA-binding transcription factor activity
AHA_1807	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AHA_1808	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AHA_1809	COG0539	negative regulation of cytoplasmic translation
AHA_1810	COG0776	regulation of translation
AHA_1812	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AHA_1816	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AHA_1817	COG0602	queuosine metabolic process
AHA_1818	COG3530	Putative quorum-sensing-regulated virulence factor
AHA_1819	COG2096	Adenosyltransferase
AHA_1820	COG2916	Histone family protein nucleoid-structuring protein H-NS
AHA_1821	COG1757	Na H antiporter
AHA_1822	COG1435	thymidine kinase activity
AHA_1827	COG3501	Rhs element vgr protein
AHA_1848	COG3501	Rhs element vgr protein
AHA_1854	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AHA_1855	COG1278	Cold shock
AHA_1856	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AHA_1857	COG0542	response to heat
AHA_1858	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AHA_1859	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AHA_1860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AHA_1861	COG3134	Outer membrane lipoprotein
AHA_1862	COG3706	GGDEF domain
AHA_1863	COG0492	ferredoxin-NADP+ reductase activity
AHA_1865	COG0531	amino acid
AHA_1865	COG1674	ftsk spoiiie
AHA_1866	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AHA_1867	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AHA_1868	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AHA_1869	COG1286	toxin biosynthetic process
AHA_1870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AHA_1872	COG4172	Belongs to the ABC transporter superfamily
AHA_1874	COG4171	peptide transport system, permease
AHA_1875	COG4168	peptide transport system, permease
AHA_1877	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AHA_1878	COG1842	Phage shock protein A
AHA_1881	COG3106	COG3106 Predicted ATPase
AHA_1882	COG3768	UPF0283 membrane protein
AHA_1884	COG2154	pterin-4-alpha-carbinolamine dehydratase
AHA_1885	COG2154	pterin-4-alpha-carbinolamine dehydratase
AHA_1888	COG2199	diguanylate cyclase activity
AHA_1889	COG2885	chlorophyll binding
AHA_1890	COG0861	Integral membrane protein TerC family
AHA_1893	COG1022	Amp-dependent synthetase and ligase
AHA_1894	COG0295	cytidine deaminase activity
AHA_1895	COG1346	cytolysis
AHA_1896	COG1380	Effector of murein hydrolase LrgA
AHA_1897	COG3345	alpha-galactosidase
AHA_1899	COG2925	Exonuclease
AHA_1900	COG2160	L-arabinose isomerase activity
AHA_1902	COG1069	ribulokinase activity
AHA_1903	COG1879	ABC-type sugar transport system periplasmic component
AHA_1905	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHA_1908	COG0583	DNA-binding transcription factor activity
AHA_1910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AHA_1911	COG0254	rRNA binding
AHA_1914	COG1451	nucleotide metabolic process
AHA_1917	COG3069	C4-dicarboxylate transmembrane transporter activity
AHA_1919	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHA_1919	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AHA_1920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHA_1923	COG2009	succinate dehydrogenase
AHA_1924	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AHA_1925	COG1053	succinate dehydrogenase
AHA_1927	COG0567	Dehydrogenase, E1 component
AHA_1928	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHA_1929	COG0045	succinate-CoA ligase (ADP-forming) activity
AHA_1930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AHA_1932	COG2983	Belongs to the UPF0260 family
AHA_1933	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHA_1935	COG3842	ATPase activity
AHA_1936	COG1840	ABC-type Fe3 transport system, periplasmic component
AHA_1938	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AHA_1940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHA_1941	COG1882	Formate acetyltransferase
AHA_1942	COG2116	formate transmembrane transporter activity
AHA_1943	COG1944	ATP diphosphatase activity
AHA_1944	COG2076	Multidrug Resistance protein
AHA_1945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AHA_1946	COG0612	Peptidase, M16
AHA_1947	COG0626	cystathionine gamma-synthase activity
AHA_1949	COG2910	NAD(P)H-binding
AHA_1950	COG0583	DNA-binding transcription factor activity
AHA_1952	COG4977	sequence-specific DNA binding
AHA_1953	COG4774	siderophore transport
AHA_1955	COG0583	DNA-binding transcription factor activity
AHA_1956	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AHA_1961	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHA_1962	COG3046	protein related to deoxyribodipyrimidine photolyase
AHA_1963	COG3033	Beta-eliminating lyase
AHA_1964	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AHA_1966	COG1120	ATPase activity
AHA_1967	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHA_1968	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AHA_1969	COG4771	TonB-dependent receptor
AHA_1973	COG0598	Magnesium transport protein CorA
AHA_1978	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AHA_1979	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AHA_1980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHA_1983	COG1570	exodeoxyribonuclease VII activity
AHA_1984	COG0697	spore germination
AHA_1988	COG3158	transport of potassium into the cell
AHA_1989	COG0516	GMP reductase activity
AHA_1989	COG0517	IMP dehydrogenase activity
AHA_1990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AHA_1990	COG0519	Catalyzes the synthesis of GMP from XMP
AHA_1998	COG2062	phosphohistidine phosphatase, SixA
AHA_2000	COG0697	spore germination
AHA_2001	COG4166	transmembrane transport
AHA_2002	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AHA_2003	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AHA_2005	COG4591	ABC-type transport system involved in lipoprotein release permease component
AHA_2006	COG1136	(ABC) transporter
AHA_2007	COG4591	ABC-type transport system involved in lipoprotein release permease component
AHA_2008	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AHA_2010	COG0544	peptidyl-prolyl cis-trans isomerase activity
AHA_2011	COG0740	serine-type endopeptidase activity
AHA_2012	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AHA_2013	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AHA_2014	COG0776	regulation of translation
AHA_2015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AHA_2016	COG0488	(ABC) transporter
AHA_2036	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AHA_2044	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AHA_2045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AHA_2056	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHA_2057	COG3162	membrane
AHA_2060	COG1024	Enoyl-CoA hydratase
AHA_2067	COG1115	amino acid carrier protein
AHA_2069	COG3228	Belongs to the MtfA family
AHA_2070	COG1584	GPR1 FUN34 yaaH family protein
AHA_2077	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AHA_2078	COG1960	acyl-CoA dehydrogenase activity
AHA_2080	COG1960	acyl-CoA dehydrogenase activity
AHA_2081	COG1024	Enoyl-CoA hydratase
AHA_2082	COG1024	Enoyl-CoA hydratase
AHA_2084	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_2086	COG0730	response to heat
AHA_2089	COG5001	Diguanylate cyclase
AHA_2089	COG3300	MHYT domain
AHA_2090	COG0583	DNA-binding transcription factor activity
AHA_2091	COG2723	6-phospho-beta-galactosidase activity
AHA_2092	COG3300	MHYT domain
AHA_2092	COG5001	Diguanylate cyclase
AHA_2094	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AHA_2096	COG0583	DNA-binding transcription factor activity
AHA_2097	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AHA_2098	COG0673	inositol 2-dehydrogenase activity
AHA_2099	COG0583	DNA-binding transcription factor activity
AHA_2101	COG1560	Kdo2-lipid A biosynthetic process
AHA_2102	COG1560	Kdo2-lipid A biosynthetic process
AHA_2107	COG0417	DNA replication proofreading
AHA_2114	COG0534	Mate efflux family protein
AHA_2116	COG0307	riboflavin synthase, alpha
AHA_2118	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHA_2119	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AHA_2120	COG0697	spore germination
AHA_2121	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AHA_2130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHA_2132	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AHA_2133	COG2894	cell division
AHA_2134	COG0850	regulation of cytokinetic process
AHA_2135	COG3100	YcgL domain-containing protein
AHA_2136	COG2951	lytic endotransglycosylase activity
AHA_2137	COG1760	l-serine dehydratase
AHA_2138	COG1760	l-serine dehydratase
AHA_2139	COG3123	guanosine phosphorylase activity
AHA_2142	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AHA_2144	COG2067	long-chain fatty acid transport protein
AHA_2147	COG1595	DNA-templated transcription, initiation
AHA_2152	COG0714	Associated with various cellular activities
AHA_2153	COG0183	Belongs to the thiolase family
AHA_2154	COG1024	Enoyl-CoA hydratase
AHA_2154	COG1250	3-hydroxyacyl-CoA dehydrogenase
AHA_2156	COG4681	YaeQ
AHA_2161	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AHA_2162	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AHA_2163	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AHA_2165	COG0549	Belongs to the carbamate kinase family
AHA_2166	COG0697	spore germination
AHA_2167	COG3608	succinylglutamate desuccinylase aspartoacylase
AHA_2167	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AHA_2168	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AHA_2169	COG2068	MobA-Related Protein
AHA_2170	COG0493	'glutamate synthase
AHA_2170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_2171	COG0402	S-adenosylhomocysteine deaminase activity
AHA_2172	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AHA_2173	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHA_2173	COG2080	2 iron, 2 sulfur cluster binding
AHA_2174	COG2233	PERMEase
AHA_2175	COG0402	S-adenosylhomocysteine deaminase activity
AHA_2176	COG2252	PERMEase
AHA_2177	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AHA_2178	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AHA_2179	COG2080	2 iron, 2 sulfur cluster binding
AHA_2181	COG3134	Outer membrane lipoprotein
AHA_2183	COG1288	antiporter activity
AHA_2184	COG0318	PFAM AMP-dependent synthetase and ligase
AHA_2186	COG0140	phosphoribosyl-ATP diphosphatase activity
AHA_2186	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AHA_2187	COG0107	imidazoleglycerol-phosphate synthase activity
AHA_2188	COG2205	protein histidine kinase activity
AHA_2188	COG2198	Histidine kinase
AHA_2188	COG0784	Response regulator, receiver
AHA_2190	COG3437	response regulator, receiver
AHA_2191	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AHA_2192	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AHA_2193	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AHA_2193	COG0131	Imidazoleglycerol-phosphate dehydratase
AHA_2194	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AHA_2195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AHA_2196	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AHA_2199	COG1199	ATP-dependent helicase activity
AHA_2201	COG1214	PFAM Peptidase M22, glycoprotease
AHA_2203	COG0596	Alpha beta hydrolase
AHA_2203	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AHA_2203	COG2226	methyltransferase
AHA_2204	COG0318	PFAM AMP-dependent synthetase and ligase
AHA_2205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AHA_2208	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AHA_2209	COG2832	Protein of unknown function (DUF454)
AHA_2210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AHA_2212	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AHA_2217	COG1643	Atp-dependent helicase
AHA_2219	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AHA_2221	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AHA_2222	COG3437	response regulator, receiver
AHA_2223	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AHA_2224	COG0709	Synthesizes selenophosphate from selenide and ATP
AHA_2227	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AHA_2230	COG1254	Belongs to the acylphosphatase family
AHA_2231	COG0625	glutathione transferase activity
AHA_2233	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHA_2233	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHA_2234	COG0489	protein tyrosine kinase activity
AHA_2235	COG0572	uridine kinase
AHA_2236	COG0717	Belongs to the dCTP deaminase family
AHA_2238	COG0306	phosphate transporter
AHA_2239	COG1530	ribonuclease E activity
AHA_2240	COG0564	pseudouridine synthase activity
AHA_2241	COG0546	phosphoglycolate phosphatase activity
AHA_2242	COG0424	maF-like protein
AHA_2243	COG2814	Major facilitator Superfamily
AHA_2246	COG1399	metal-binding, possibly nucleic acid-binding protein
AHA_2247	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AHA_2248	COG0416	fatty acid biosynthetic process
AHA_2249	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AHA_2251	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_2252	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AHA_2254	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHA_2255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AHA_2256	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AHA_2257	COG0470	DNA polymerase III
AHA_2258	COG0084	hydrolase, TatD family'
AHA_2262	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AHA_2262	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AHA_2263	COG3008	intermembrane lipid transfer
AHA_2265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AHA_2266	COG0372	Belongs to the citrate synthase family
AHA_2275	COG4221	oxidoreductase activity
AHA_2277	COG3141	response to X-ray
AHA_2279	COG1067	ATP-dependent peptidase activity
AHA_2280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AHA_2283	COG0488	(ABC) transporter
AHA_2285	COG0116	Belongs to the methyltransferase superfamily
AHA_2285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AHA_2287	COG0167	dihydroorotate dehydrogenase activity
AHA_2288	COG2902	Dehydrogenase
AHA_2290	COG0308	aminopeptidase N
AHA_2292	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AHA_2293	COG1956	GAF domain-containing protein
AHA_2295	COG3278	Belongs to the heme-copper respiratory oxidase family
AHA_2298	COG2010	Cytochrome c
AHA_2303	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AHA_2304	COG0589	response to stress
AHA_2305	COG0037	tRNA processing
AHA_2309	COG1869	D-ribose catabolic process
AHA_2310	COG1129	ABC transporter
AHA_2311	COG1172	Belongs to the binding-protein-dependent transport system permease family
AHA_2312	COG1879	ABC-type sugar transport system periplasmic component
AHA_2313	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHA_2314	COG1609	Transcriptional regulator
AHA_2315	COG5001	Diguanylate cyclase
AHA_2315	COG3300	MHYT domain
AHA_2317	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AHA_2321	COG0776	regulation of translation
AHA_2322	COG0072	phenylalanine-tRNA ligase activity
AHA_2322	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AHA_2323	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AHA_2324	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AHA_2325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AHA_2326	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AHA_2327	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AHA_2331	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AHA_2333	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHA_2334	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AHA_2335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AHA_2336	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AHA_2337	COG3313	Fe-S protein
AHA_2338	COG2942	2-epimerase
AHA_2339	COG3716	PTS system mannose fructose sorbose family IID component
AHA_2340	COG3715	PTS system
AHA_2341	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_2341	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_2344	COG1609	Transcriptional regulator
AHA_2345	COG2140	Oxalate decarboxylase
AHA_2346	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AHA_2346	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_2346	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AHA_2347	COG1105	Belongs to the carbohydrate kinase PfkB family
AHA_2348	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_2348	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_2349	COG1609	Transcriptional regulator
AHA_2350	COG0814	amino acid
AHA_2352	COG5654	RES domain protein
AHA_2353	COG0513	Belongs to the DEAD box helicase family
AHA_2355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AHA_2356	COG2890	protein-(glutamine-N5) methyltransferase activity
AHA_2357	COG2840	Smr protein MutS2
AHA_2359	COG3706	GGDEF domain
AHA_2360	COG0588	phosphoglycerate mutase activity
AHA_2365	COG2824	Alkylphosphonate utilization operon protein PhnA
AHA_2368	COG0384	phenazine biosynthesis protein PhzF
AHA_2373	COG0242	peptide deformylase activity
AHA_2377	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AHA_2378	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AHA_2380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AHA_2381	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AHA_2383	COG0205	6-phosphofructokinase activity
AHA_2384	COG1473	amidohydrolase
AHA_2385	COG1011	Hydrolase
AHA_2386	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHA_2397	COG3593	DNA synthesis involved in DNA repair
AHA_2400	COG0583	DNA-binding transcription factor activity
AHA_2401	COG0730	response to heat
AHA_2404	COG1181	Belongs to the D-alanine--D-alanine ligase family
AHA_2406	COG0386	Belongs to the glutathione peroxidase family
AHA_2407	COG0513	Belongs to the DEAD box helicase family
AHA_2408	COG0456	acetyltransferase
AHA_2410	COG1742	UPF0060 membrane protein
AHA_2416	COG2329	Antibiotic biosynthesis monooxygenase
AHA_2417	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AHA_2421	COG3243	poly(R)-hydroxyalkanoic acid synthase
AHA_2423	COG2501	S4 domain
AHA_2425	COG1132	(ABC) transporter
AHA_2427	COG1132	(ABC) transporter
AHA_2429	COG3118	belongs to the thioredoxin family
AHA_2430	COG0471	metal ion transport
AHA_2431	COG0058	SHG alpha-glucan phosphorylase activity
AHA_2437	COG0814	amino acid
AHA_2438	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AHA_2439	COG0514	ATP-dependent DNA helicase (RecQ)
AHA_2440	COG2766	serine protein kinase
AHA_2441	COG2718	Belongs to the UPF0229 family
AHA_2442	COG2719	SpoVR family
AHA_2443	COG2186	Transcriptional regulator
AHA_2444	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AHA_2445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AHA_2446	COG0586	Pfam SNARE associated Golgi protein
AHA_2448	COG0556	nucleotide-excision repair
AHA_2450	COG0569	domain protein
AHA_2450	COG2985	domain, Protein
AHA_2451	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AHA_2455	COG4565	transcriptional regulatory protein
AHA_2456	COG3290	protein histidine kinase activity
AHA_2457	COG1846	Transcriptional regulator
AHA_2457	COG1940	carbohydrate kinase activity
AHA_2458	COG0840	transmembrane signaling receptor activity
AHA_2459	COG3012	SEC-C Motif Domain Protein
AHA_2460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AHA_2461	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AHA_2462	COG0247	lactate metabolic process
AHA_2465	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AHA_2466	COG0437	4 iron, 4 sulfur cluster binding
AHA_2467	COG3301	Polysulphide reductase, NrfD
AHA_2468	COG1138	Cytochrome C-type biogenesis protein
AHA_2469	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHA_2470	COG4235	cytochrome complex assembly
AHA_2470	COG3088	subunit of a heme lyase
AHA_2471	COG1051	belongs to the nudix hydrolase family
AHA_2473	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AHA_2475	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_2476	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AHA_2477	COG1535	isochorismatase
AHA_2477	COG3433	isochorismatase activity
AHA_2478	COG1021	2,3-dihydroxybenzoate-AMP ligase
AHA_2482	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHA_2484	COG5001	Diguanylate cyclase
AHA_2484	COG3300	MHYT domain
AHA_2486	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHA_2488	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AHA_2489	COG0563	adenylate kinase activity
AHA_2490	COG0326	Molecular chaperone. Has ATPase activity
AHA_2491	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AHA_2496	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_2498	COG3158	transport of potassium into the cell
AHA_2499	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AHA_2500	COG0651	ATP synthesis coupled electron transport
AHA_2501	COG0650	Formate hydrogenlyase subunit 4
AHA_2502	COG3261	NADH dehydrogenase
AHA_2502	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AHA_2503	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_2504	COG3260	NADH ubiquinone oxidoreductase 20
AHA_2506	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AHA_2508	COG1921	L-seryl-tRNASec selenium transferase activity
AHA_2510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AHA_2511	COG0298	carbon dioxide binding
AHA_2513	COG0309	Hydrogenase expression formation protein (HypE)
AHA_2514	COG0375	protein maturation
AHA_2515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AHA_2516	COG3842	ATPase activity
AHA_2517	COG0444	Belongs to the ABC transporter superfamily
AHA_2518	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHA_2519	COG0601	transmembrane transport
AHA_2521	COG1773	rubredoxin
AHA_2522	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AHA_2523	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AHA_2524	COG5557	Pfam Polysulphide reductase, NrfD
AHA_2525	COG0437	4 iron, 4 sulfur cluster binding
AHA_2526	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AHA_2527	COG0745	RESPONSE REGULATOR receiver
AHA_2529	COG0643	Histidine kinase
AHA_2529	COG2198	Histidine kinase
AHA_2530	COG0840	transmembrane signaling receptor activity
AHA_2530	COG3290	protein histidine kinase activity
AHA_2531	COG0835	chemotaxis
AHA_2533	COG2201	protein-glutamate methylesterase activity
AHA_2535	COG0840	transmembrane signaling receptor activity
AHA_2536	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHA_2540	COG0659	secondary active sulfate transmembrane transporter activity
AHA_2546	COG0672	)-iron permease
AHA_2550	COG2814	Major facilitator Superfamily
AHA_2552	COG1136	(ABC) transporter
AHA_2558	COG1139	Iron-sulfur cluster binding protein
AHA_2560	COG1620	l-lactate permease
AHA_2561	COG0583	DNA-binding transcription factor activity
AHA_2563	COG0346	lactoylglutathione lyase activity
AHA_2564	COG0596	Alpha beta hydrolase
AHA_2568	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AHA_2569	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AHA_2569	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AHA_2570	COG0527	aspartate kinase activity
AHA_2572	COG1368	sulfuric ester hydrolase activity
AHA_2573	COG1619	proteins homologs of microcin C7 resistance protein MccF
AHA_2574	COG4667	esterase of the alpha-beta hydrolase superfamily
AHA_2577	COG2221	Nitrite and sulphite reductase 4Fe-4S
AHA_2578	COG1648	precorrin-2 dehydrogenase activity
AHA_2578	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHA_2580	COG0393	Putative heavy-metal-binding
AHA_2584	COG1252	NADH dehydrogenase
AHA_2586	COG2233	PERMEase
AHA_2589	COG2354	Protein conserved in bacteria
AHA_2591	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHA_2592	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AHA_2599	COG0537	adenosine 5'-monophosphoramidase activity
AHA_2602	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AHA_2605	COG1301	dicarboxylic acid transport
AHA_2607	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AHA_2608	COG0861	Integral membrane protein TerC family
AHA_2610	COG0444	Belongs to the ABC transporter superfamily
AHA_2611	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHA_2612	COG0601	transmembrane transport
AHA_2614	COG2095	MarC family integral membrane protein
AHA_2616	COG1454	alcohol dehydrogenase
AHA_2616	COG1012	belongs to the aldehyde dehydrogenase family
AHA_2617	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AHA_2617	COG2199	diguanylate cyclase activity
AHA_2618	COG3275	phosphorelay sensor kinase activity
AHA_2619	COG3279	Response regulator of the LytR AlgR family
AHA_2620	COG1966	Carbon starvation protein
AHA_2622	COG1566	PFAM secretion protein HlyD family protein
AHA_2623	COG1061	Type III restriction enzyme res subunit
AHA_2624	COG2027	D-alanyl-D-alanine carboxypeptidase
AHA_2625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AHA_2627	COG0436	Aminotransferase
AHA_2628	COG1288	antiporter activity
AHA_2629	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AHA_2633	COG0697	spore germination
AHA_2634	COG4657	Part of a membrane complex involved in electron transport
AHA_2635	COG2878	Part of a membrane complex involved in electron transport
AHA_2637	COG4658	electron transport chain
AHA_2638	COG4659	FMN binding
AHA_2640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AHA_2641	COG0346	lactoylglutathione lyase activity
AHA_2644	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AHA_2645	COG2056	Na+-H+ antiporter family
AHA_2647	COG2050	protein possibly involved in aromatic compounds catabolism
AHA_2649	COG0277	FAD linked oxidase domain protein
AHA_2649	COG0247	lactate metabolic process
AHA_2651	COG1253	flavin adenine dinucleotide binding
AHA_2652	COG1902	pentaerythritol trinitrate reductase activity
AHA_2653	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AHA_2654	COG0647	UMP catabolic process
AHA_2655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AHA_2655	COG4651	solute:proton antiporter activity
AHA_2657	COG0367	asparagine synthase
AHA_2659	COG0625	glutathione transferase activity
AHA_2660	COG0625	glutathione transferase activity
AHA_2662	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AHA_2665	COG0564	pseudouridine synthase activity
AHA_2666	COG5001	Diguanylate cyclase
AHA_2667	COG0840	transmembrane signaling receptor activity
AHA_2669	COG0392	lysyltransferase activity
AHA_2669	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AHA_2670	COG2194	sulfuric ester hydrolase activity
AHA_2674	COG0670	Belongs to the BI1 family
AHA_2675	COG1289	transmembrane transporter activity
AHA_2676	COG2920	part of a sulfur-relay system
AHA_2677	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AHA_2678	COG0285	dihydrofolate synthase activity
AHA_2679	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AHA_2680	COG0101	tRNA pseudouridine synthase activity
AHA_2682	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AHA_2683	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHA_2684	COG0671	phosphoesterase, PA-phosphatase related
AHA_2685	COG1464	Belongs to the NlpA lipoprotein family
AHA_2691	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AHA_2691	COG0574	Belongs to the PEP-utilizing enzyme family
AHA_2692	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AHA_2702	COG1242	4 iron, 4 sulfur cluster binding
AHA_2703	COG0067	glutamate synthase
AHA_2703	COG0070	glutamate synthase
AHA_2703	COG0069	glutamate synthase activity
AHA_2704	COG0493	'glutamate synthase
AHA_2706	COG0765	amino acid transport
AHA_2707	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_2710	COG0789	Transcriptional regulator
AHA_2713	COG4104	PAAR repeat-containing protein
AHA_2715	COG0513	Belongs to the DEAD box helicase family
AHA_2716	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AHA_2722	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AHA_2723	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AHA_2724	COG0505	Belongs to the CarA family
AHA_2725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AHA_2727	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AHA_2728	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AHA_2729	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AHA_2730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AHA_2731	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AHA_2732	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AHA_2733	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHA_2735	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AHA_2737	COG2205	protein histidine kinase activity
AHA_2737	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_2740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHA_2745	COG0023	Translation Initiation Factor
AHA_2746	COG2119	membrane
AHA_2752	COG2199	diguanylate cyclase activity
AHA_2752	COG2203	Gaf domain
AHA_2754	COG1078	dGTPase activity
AHA_2756	COG0215	cysteine-tRNA ligase activity
AHA_2757	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AHA_2759	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AHA_2760	COG3301	Polysulphide reductase, NrfD
AHA_2761	COG0437	4 iron, 4 sulfur cluster binding
AHA_2762	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AHA_2773	COG0322	excinuclease ABC activity
AHA_2774	COG2197	response regulator
AHA_2775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AHA_2776	COG2835	tetraacyldisaccharide 4'-kinase activity
AHA_2777	COG1663	tetraacyldisaccharide 4'-kinase activity
AHA_2778	COG1132	(ABC) transporter
AHA_2779	COG2333	competence protein COMEC
AHA_2779	COG0658	competence protein
AHA_2782	COG0433	COG0433 Predicted ATPase
AHA_2783	COG1448	Aminotransferase
AHA_2785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AHA_2786	COG1199	ATP-dependent helicase activity
AHA_2788	COG0123	including yeast histone deacetylase and acetoin utilization protein
AHA_2789	COG0477	Major facilitator Superfamily
AHA_2790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AHA_2795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AHA_2798	COG2271	Major facilitator Superfamily
AHA_2799	COG3706	GGDEF domain
AHA_2800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_2801	COG0765	amino acid transport
AHA_2802	COG1126	abc transporter atp-binding protein
AHA_2806	COG0531	amino acid
AHA_2809	COG1253	flavin adenine dinucleotide binding
AHA_2810	COG0704	Plays a role in the regulation of phosphate uptake
AHA_2812	COG0581	inorganic phosphate transmembrane transporter activity
AHA_2813	COG0573	inorganic phosphate transmembrane transporter activity
AHA_2814	COG0590	tRNA wobble adenosine to inosine editing
AHA_2816	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AHA_2820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AHA_2821	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AHA_2822	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AHA_2823	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AHA_2824	COG2204	response regulator
AHA_2825	COG3852	Histidine kinase
AHA_2826	COG2204	response regulator
AHA_2828	COG2716	regulation of RNA biosynthetic process
AHA_2829	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AHA_2830	COG0248	Ppx GppA phosphatase
AHA_2831	COG2239	Acts as a magnesium transporter
AHA_2833	COG1256	bacterial-type flagellum assembly
AHA_2835	COG1706	bacterial-type flagellum-dependent cell motility
AHA_2836	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AHA_2837	COG4786	Flagellar basal body rod
AHA_2838	COG4787	bacterial-type flagellum-dependent cell motility
AHA_2841	COG1558	bacterial-type flagellum-dependent cell motility
AHA_2842	COG1815	bacterial-type flagellum-dependent cell motility
AHA_2843	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AHA_2844	COG0835	chemotaxis
AHA_2844	COG0784	Response regulator, receiver
AHA_2845	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AHA_2848	COG0622	Phosphoesterase
AHA_2851	COG1187	pseudouridine synthase activity
AHA_2854	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AHA_2855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AHA_2857	COG1349	DNA-binding transcription factor activity
AHA_2858	COG0697	spore germination
AHA_2864	COG1278	Cold shock
AHA_2872	COG3132	Protein of unknown function, DUF480
AHA_2874	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AHA_2877	COG3206	protein involved in exopolysaccharide biosynthesis
AHA_2877	COG0489	protein tyrosine kinase activity
AHA_2878	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AHA_2883	COG1215	transferase activity, transferring glycosyl groups
AHA_2885	COG0438	transferase activity, transferring glycosyl groups
AHA_2892	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AHA_2895	COG1051	belongs to the nudix hydrolase family
AHA_2901	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AHA_2902	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AHA_2903	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHA_2906	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AHA_2907	COG1091	dTDP-4-dehydrorhamnose reductase activity
AHA_2909	COG1538	Outer membrane efflux protein
AHA_2910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_2911	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_2912	COG1309	transcriptional regulator
AHA_2916	COG1946	Acyl-CoA thioesterase
AHA_2918	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AHA_2920	COG0009	L-threonylcarbamoyladenylate synthase
AHA_2923	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AHA_2924	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AHA_2924	COG0512	Glutamine amidotransferase of anthranilate synthase
AHA_2925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AHA_2926	COG0134	indole-3-glycerol-phosphate synthase activity
AHA_2926	COG0135	phosphoribosylanthranilate isomerase activity
AHA_2927	COG0133	tryptophan synthase activity
AHA_2928	COG0159	tryptophan synthase activity
AHA_2930	COG1988	membrane-bound metal-dependent
AHA_2934	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AHA_2936	COG4521	taurine ABC transporter
AHA_2937	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AHA_2938	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AHA_2939	COG2175	clavaminate synthase activity
AHA_2941	COG2814	Major facilitator Superfamily
AHA_2942	COG0109	protoheme IX farnesyltransferase activity
AHA_2943	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AHA_2944	COG1845	cytochrome c oxidase, subunit III
AHA_2945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AHA_2946	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AHA_2955	COG2211	Major facilitator Superfamily
AHA_2958	COG0708	Exodeoxyribonuclease III
AHA_2962	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_2963	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AHA_2967	COG0095	Lipoate-protein ligase
AHA_2973	COG0640	Transcriptional regulator
AHA_2976	COG1285	pathogenesis
AHA_2982	COG0484	heat shock protein binding
AHA_2983	COG0443	Heat shock 70 kDa protein
AHA_2984	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AHA_2985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AHA_2986	COG0497	DNA recombination
AHA_2987	COG1227	inorganic diphosphatase activity
AHA_2989	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_2990	COG1136	(ABC) transporter
AHA_2990	COG0577	efflux transmembrane transporter activity
AHA_2991	COG1538	Outer membrane efflux protein
AHA_2992	COG2375	cellular response to nickel ion
AHA_2993	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AHA_2997	COG3152	Membrane
AHA_2999	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AHA_3000	COG1396	sequence-specific DNA binding
AHA_3000	COG1917	Cupin 2, conserved barrel domain protein
AHA_3003	COG0531	amino acid
AHA_3004	COG0531	amino acid
AHA_3006	COG1283	sodium-dependent phosphate transmembrane transporter activity
AHA_3008	COG3384	dioxygenase
AHA_3009	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AHA_3009	COG2205	protein histidine kinase activity
AHA_3010	COG0813	purine-nucleoside phosphorylase activity
AHA_3013	COG0488	(ABC) transporter
AHA_3016	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AHA_3017	COG0083	homoserine kinase activity
AHA_3020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AHA_3021	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AHA_3024	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AHA_3026	COG0745	RESPONSE REGULATOR receiver
AHA_3029	COG4988	ABC transporter
AHA_3030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AHA_3034	COG1720	tRNA m6t6A37 methyltransferase activity
AHA_3037	COG0542	response to heat
AHA_3038	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AHA_3039	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_3041	COG2190	(PTS) system
AHA_3044	COG3038	cytochrome b561
AHA_3046	COG0420	3'-5' exonuclease activity
AHA_3048	COG2974	May be involved in recombination
AHA_3050	COG4651	solute:proton antiporter activity
AHA_3050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AHA_3052	COG0469	pyruvate kinase activity
AHA_3053	COG3264	Mechanosensitive ion channel
AHA_3053	COG1196	nuclear chromosome segregation
AHA_3055	COG2706	6-phosphogluconolactonase activity
AHA_3059	COG0281	malic enzyme
AHA_3062	COG0437	4 iron, 4 sulfur cluster binding
AHA_3063	COG3383	formate dehydrogenase (NAD+) activity
AHA_3063	COG3383	formate dehydrogenase (NAD+) activity
AHA_3070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AHA_3071	COG1910	domain protein
AHA_3072	COG3852	Histidine kinase
AHA_3073	COG2204	response regulator
AHA_3075	COG4662	Binding-protein-dependent transport system inner membrane component
AHA_3077	COG0746	molybdenum cofactor guanylyltransferase activity
AHA_3078	COG0303	'Molybdopterin
AHA_3079	COG1289	transmembrane transporter activity
AHA_3080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AHA_3086	COG3220	belongs to the UPF0276 family
AHA_3093	COG4166	transmembrane transport
AHA_3094	COG0601	transmembrane transport
AHA_3095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AHA_3096	COG0444	Belongs to the ABC transporter superfamily
AHA_3097	COG4608	Belongs to the ABC transporter superfamily
AHA_3099	COG2971	BadF BadG BcrA BcrD
AHA_3101	COG0840	transmembrane signaling receptor activity
AHA_3104	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHA_3105	COG3724	N-succinylarginine dihydrolase activity
AHA_3106	COG0616	signal peptide processing
AHA_3107	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_3108	COG0583	DNA-binding transcription factor activity
AHA_3110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AHA_3112	COG0583	DNA-binding transcription factor activity
AHA_3114	COG1881	PFAM PEBP family protein
AHA_3116	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AHA_3116	COG3408	Glycogen debranching enzyme
AHA_3117	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AHA_3118	COG0739	heme binding
AHA_3119	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AHA_3123	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AHA_3125	COG3091	SprT-like family
AHA_3127	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AHA_3128	COG0189	ligase activity
AHA_3130	COG1678	Uncharacterized ACR, COG1678
AHA_3131	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AHA_3132	COG3104	oligopeptide transport
AHA_3136	COG0714	Associated with various cellular activities
AHA_3139	COG1115	amino acid carrier protein
AHA_3140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AHA_3142	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AHA_3144	COG1301	dicarboxylic acid transport
AHA_3145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AHA_3146	COG2912	Transglutaminase-like superfamily
AHA_3148	COG2890	protein-(glutamine-N5) methyltransferase activity
AHA_3149	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AHA_3150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AHA_3151	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AHA_3152	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AHA_3154	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AHA_3155	COG0737	Belongs to the 5'-nucleotidase family
AHA_3156	COG0193	aminoacyl-tRNA hydrolase activity
AHA_3157	COG0012	GTP binding
AHA_3166	COG0490	domain, Protein
AHA_3166	COG0471	metal ion transport
AHA_3172	COG0366	Alpha amylase catalytic
AHA_3174	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AHA_3174	COG0674	pyruvate-flavodoxin oxidoreductase activity
AHA_3174	COG1013	pyruvate-flavodoxin oxidoreductase activity
AHA_3174	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AHA_3176	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHA_3178	COG1012	belongs to the aldehyde dehydrogenase family
AHA_3180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AHA_3183	COG0180	Tryptophanyl-tRNA synthetase
AHA_3185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AHA_3186	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AHA_3188	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AHA_3189	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AHA_3195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AHA_3196	COG0583	DNA-binding transcription factor activity
AHA_3200	COG0583	DNA-binding transcription factor activity
AHA_3203	COG0739	heme binding
AHA_3205	COG1511	domain protein
AHA_3205	COG3264	Mechanosensitive ion channel
AHA_3206	COG0584	glycerophosphoryl diester phosphodiesterase
AHA_3208	COG1053	succinate dehydrogenase
AHA_3209	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AHA_3210	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AHA_3215	COG3214	Protein conserved in bacteria
AHA_3222	COG0745	RESPONSE REGULATOR receiver
AHA_3223	COG0642	Histidine kinase
AHA_3225	COG0516	GMP reductase activity
AHA_3227	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AHA_3228	COG3647	Membrane
AHA_3230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AHA_3232	COG3706	GGDEF domain
AHA_3234	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHA_3237	COG3706	GGDEF domain
AHA_3239	COG1335	isochorismatase
AHA_3240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AHA_3241	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AHA_3242	COG1702	phosphate starvation-inducible protein PhoH
AHA_3243	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AHA_3244	COG4535	Mg2 and Co2 transporter CorC
AHA_3245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AHA_3246	COG2888	peptidyl-tyrosine sulfation
AHA_3247	COG0495	leucyl-tRNA aminoacylation
AHA_3251	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AHA_3252	COG0799	negative regulation of ribosome biogenesis
AHA_3253	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AHA_3254	COG0768	penicillin binding
AHA_3255	COG0772	Belongs to the SEDS family
AHA_3256	COG0772	Belongs to the SEDS family
AHA_3257	COG2951	lytic endotransglycosylase activity
AHA_3258	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AHA_3259	COG1686	Belongs to the peptidase S11 family
AHA_3260	COG2921	Belongs to the UPF0250 family
AHA_3261	COG0321	lipoyl(octanoyl) transferase activity
AHA_3263	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AHA_3265	COG3545	Serine hydrolase
AHA_3266	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AHA_3269	COG0789	Transcriptional regulator
AHA_3271	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AHA_3272	COG1970	mechanosensitive ion channel activity
AHA_3273	COG4974	Belongs to the 'phage' integrase family
AHA_3274	COG3706	GGDEF domain
AHA_3275	COG0716	FMN binding
AHA_3276	COG0312	modulator of DNA gyrase
AHA_3277	COG0312	modulator of DNA gyrase
AHA_3290	COG3275	phosphorelay sensor kinase activity
AHA_3291	COG3279	Response regulator of the LytR AlgR family
AHA_3292	COG1966	Carbon starvation protein
AHA_3294	COG0114	fumarate hydratase activity
AHA_3296	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AHA_3298	COG2211	Major facilitator Superfamily
AHA_3299	COG1185	polyribonucleotide nucleotidyltransferase activity
AHA_3300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AHA_3301	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AHA_3302	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AHA_3303	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AHA_3304	COG0195	Participates in both transcription termination and antitermination
AHA_3305	COG0779	Required for maturation of 30S ribosomal subunits
AHA_3308	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AHA_3309	COG0149	triose-phosphate isomerase activity
AHA_3310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AHA_3311	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AHA_3312	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AHA_3313	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AHA_3314	COG1534	Rna-binding protein
AHA_3316	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AHA_3317	COG1360	Flagellar Motor Protein
AHA_3318	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AHA_3319	COG1722	exodeoxyribonuclease VII activity
AHA_3320	COG0142	geranyltranstransferase activity
AHA_3321	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AHA_3326	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AHA_3327	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AHA_3328	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AHA_3329	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AHA_3333	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AHA_3333	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AHA_3334	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AHA_3336	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AHA_3338	COG3381	protein complex oligomerization
AHA_3342	COG3300	MHYT domain
AHA_3342	COG5001	Diguanylate cyclase
AHA_3344	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AHA_3345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AHA_3346	COG0511	ligase activity, forming carbon-carbon bonds
AHA_3347	COG0439	Biotin carboxylase
AHA_3349	COG4145	pantothenate transmembrane transporter activity
AHA_3350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_3350	COG2190	(PTS) system
AHA_3350	COG1263	PTS System
AHA_3351	COG0583	DNA-binding transcription factor activity
AHA_3352	COG0604	alcohol dehydrogenase
AHA_3353	COG2264	protein methyltransferase activity
AHA_3356	COG0778	Nitroreductase
AHA_3357	COG0446	pyridine nucleotide-disulphide oxidoreductase
AHA_3357	COG1902	pentaerythritol trinitrate reductase activity
AHA_3358	COG0616	signal peptide processing
AHA_3362	COG3139	Protein of unknown function (DUF1315)
AHA_3363	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AHA_3364	COG0714	Associated with various cellular activities
AHA_3365	COG0252	asparaginase activity
AHA_3366	COG0786	glutamate:sodium symporter activity
AHA_3369	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AHA_3370	COG0384	phenazine biosynthesis protein PhzF
AHA_3371	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AHA_3372	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHA_3373	COG0175	sulfate reduction
AHA_3374	COG2113	Glycine betaine
AHA_3375	COG4176	ABC-type proline glycine betaine transport system permease component
AHA_3376	COG4175	Glycine betaine
AHA_3378	COG3610	response to peptide
AHA_3379	COG2966	Psort location CytoplasmicMembrane, score
AHA_3381	COG0521	Mo-molybdopterin cofactor biosynthetic process
AHA_3382	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHA_3383	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_3385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AHA_3390	COG2986	histidine ammonia-lyase
AHA_3395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AHA_3396	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AHA_3403	COG1858	cytochrome C peroxidase
AHA_3405	COG2313	pseudouridylate synthase activity
AHA_3406	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AHA_3407	COG2146	nitrite reductase [NAD(P)H] activity
AHA_3407	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHA_3408	COG2146	nitrite reductase [NAD(P)H] activity
AHA_3408	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHA_3409	COG1116	anion transmembrane transporter activity
AHA_3410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AHA_3411	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AHA_3411	COG1116	anion transmembrane transporter activity
AHA_3414	COG0243	molybdopterin cofactor binding
AHA_3420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AHA_3424	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AHA_3426	COG2195	Cleaves the N-terminal amino acid of tripeptides
AHA_3428	COG4608	Belongs to the ABC transporter superfamily
AHA_3429	COG0444	Belongs to the ABC transporter superfamily
AHA_3431	COG4239	(ABC) transporter, permease
AHA_3432	COG4174	ABC transporter (Permease)
AHA_3435	COG0811	peptide transport
AHA_3436	COG0811	peptide transport
AHA_3437	COG0848	biopolymer transport protein
AHA_3447	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHA_3448	COG0840	transmembrane signaling receptor activity
AHA_3450	COG1278	Cold shock
AHA_3459	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AHA_3460	COG1162	GTPase activity
AHA_3461	COG0688	phosphatidylethanolamine metabolic process
AHA_3462	COG4628	conserved protein (DUF2132)
AHA_3465	COG3059	membrane
AHA_3466	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AHA_3469	COG5001	Diguanylate cyclase
AHA_3469	COG3300	MHYT domain
AHA_3470	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AHA_3471	COG4412	M6 family metalloprotease domain protein
AHA_3471	COG3291	Pkd domain containing protein
AHA_3476	COG1132	(ABC) transporter
AHA_3478	COG1404	Belongs to the peptidase S8 family
AHA_3479	COG2897	thiosulfate sulfurtransferase activity
AHA_3480	COG2066	Belongs to the glutaminase family
AHA_3481	COG3171	Protein conserved in bacteria
AHA_3482	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AHA_3483	COG4935	Belongs to the peptidase S8 family
AHA_3483	COG2234	aminopeptidase activity
AHA_3484	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHA_3485	COG2200	EAL domain
AHA_3486	COG1090	epimerase
AHA_3487	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AHA_3488	COG4181	ATPase activity
AHA_3489	COG2755	lipolytic protein G-D-S-L family
AHA_3490	COG0835	chemotaxis
AHA_3490	COG0784	Response regulator, receiver
AHA_3492	COG0569	domain protein
AHA_3492	COG2985	domain, Protein
AHA_3493	COG1272	protein, Hemolysin III
AHA_3494	COG0076	glutamate decarboxylase activity
AHA_3495	COG2917	probably involved in intracellular septation
AHA_3496	COG2350	Protein conserved in bacteria
AHA_3498	COG1555	photosystem II stabilization
AHA_3499	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AHA_3500	COG3104	oligopeptide transport
AHA_3501	COG0745	RESPONSE REGULATOR receiver
AHA_3508	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AHA_3511	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AHA_3512	COG1280	lysine exporter protein (LysE YggA)
AHA_3517	COG0316	Belongs to the HesB IscA family
AHA_3519	COG0038	chloride channel
AHA_3520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AHA_3523	COG0671	phosphoesterase, PA-phosphatase related
AHA_3525	COG3437	response regulator, receiver
AHA_3525	COG0784	Response regulator, receiver
AHA_3527	COG2076	Multidrug Resistance protein
AHA_3529	COG0346	lactoylglutathione lyase activity
AHA_3530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AHA_3531	COG1643	Atp-dependent helicase
AHA_3533	COG1489	DNA binding
AHA_3534	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AHA_3535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AHA_3538	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AHA_3539	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AHA_3542	COG1924	4 iron, 4 sulfur cluster binding
AHA_3543	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AHA_3544	COG0842	Transport permease protein
AHA_3545	COG1131	(ABC) transporter
AHA_3548	COG0163	prenyltransferase activity
AHA_3549	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AHA_3550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AHA_3554	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AHA_3561	COG0840	transmembrane signaling receptor activity
AHA_3564	COG0529	Catalyzes the synthesis of activated sulfate
AHA_3565	COG0471	metal ion transport
AHA_3565	COG3273	potassium ion transport
AHA_3566	COG2895	sulfate adenylyltransferase (ATP) activity
AHA_3567	COG0175	sulfate reduction
AHA_3568	COG1648	precorrin-2 dehydrogenase activity
AHA_3568	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHA_3569	COG0330	HflC and HflK could
AHA_3570	COG1585	Membrane protein implicated in regulation of membrane protease activity
AHA_3571	COG0517	IMP dehydrogenase activity
AHA_3571	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AHA_3572	COG0488	(ABC) transporter
AHA_3574	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AHA_3575	COG0583	DNA-binding transcription factor activity
AHA_3583	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AHA_3585	COG0668	transmembrane transport
AHA_3587	COG2731	YhcH YjgK YiaL family protein
AHA_3590	COG1794	racemase activity, acting on amino acids and derivatives
AHA_3592	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AHA_3598	COG0733	neurotransmitter:sodium symporter activity
AHA_3600	COG0733	neurotransmitter:sodium symporter activity
AHA_3603	COG0561	phosphatase activity
AHA_3606	COG1522	sequence-specific DNA binding
AHA_3609	COG1846	Transcriptional regulator
AHA_3610	COG1764	response to oxidative stress
AHA_3611	COG2130	NADP-dependent
AHA_3612	COG1051	belongs to the nudix hydrolase family
AHA_3616	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AHA_3617	COG1640	4-alpha-glucanotransferase
AHA_3618	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AHA_3619	COG0676	glucose-6-phosphate 1-epimerase activity
AHA_3620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AHA_3621	COG0840	transmembrane signaling receptor activity
AHA_3636	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AHA_3637	COG2885	chlorophyll binding
AHA_3638	COG0823	Involved in the tonB-independent uptake of proteins
AHA_3641	COG0811	peptide transport
AHA_3642	COG0824	Thioesterase
AHA_3643	COG3790	cyd operon protein YbgE
AHA_3644	COG4890	Cyd operon protein YbgT
AHA_3645	COG1294	oxidase, subunit
AHA_3646	COG1271	oxidase subunit
AHA_3647	COG2255	four-way junction helicase activity
AHA_3648	COG0632	four-way junction helicase activity
AHA_3649	COG0840	transmembrane signaling receptor activity
AHA_3650	COG0442	prolyl-tRNA aminoacylation
AHA_3651	COG4221	oxidoreductase activity
AHA_3654	COG1024	Enoyl-CoA hydratase
AHA_3658	COG4166	transmembrane transport
AHA_3661	COG1872	DUF167
AHA_3662	COG0762	integral membrane protein
AHA_3663	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AHA_3664	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AHA_3667	COG3022	response to hydroperoxide
AHA_3668	COG0513	Belongs to the DEAD box helicase family
AHA_3669	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AHA_3674	COG0735	belongs to the Fur family
AHA_3675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AHA_3678	COG0776	regulation of translation
AHA_3679	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AHA_3685	COG0560	Phosphoserine phosphatase
AHA_3686	COG5002	protein histidine kinase activity
AHA_3686	COG5001	Diguanylate cyclase
AHA_3686	COG3447	MASE1 domain protein
AHA_3687	COG0813	purine-nucleoside phosphorylase activity
AHA_3688	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AHA_3689	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AHA_3690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AHA_3691	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AHA_3692	COG0084	hydrolase, TatD family'
AHA_3694	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHA_3695	COG0004	ammonium transporteR
AHA_3698	COG0795	lipopolysaccharide-transporting ATPase activity
AHA_3699	COG0795	lipopolysaccharide-transporting ATPase activity
AHA_3700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AHA_3701	COG2927	DNA polymerase III (CHI subunit)
AHA_3702	COG0525	valine-tRNA ligase activity
AHA_3703	COG1253	flavin adenine dinucleotide binding
AHA_3704	COG0586	Pfam SNARE associated Golgi protein
AHA_3705	COG1686	Belongs to the peptidase S11 family
AHA_3712	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AHA_3713	COG0527	aspartate kinase activity
AHA_3714	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AHA_3716	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AHA_3717	COG1546	Belongs to the CinA family
AHA_3718	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AHA_3722	COG3068	Protein conserved in bacteria
AHA_3724	COG0739	heme binding
AHA_3728	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AHA_3729	COG1121	(ABC) transporter
AHA_3730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AHA_3731	COG0583	DNA-binding transcription factor activity
AHA_3732	COG0697	spore germination
AHA_3733	COG1573	uracil-dna glycosylase
AHA_3735	COG2962	Rard protein
AHA_3736	COG2827	Endonuclease containing a URI domain
AHA_3739	COG1842	Phage shock protein A
AHA_3740	COG0204	Acyl-transferase
AHA_3745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AHA_3753	COG0583	DNA-binding transcription factor activity
AHA_3756	COG0187	DNA topoisomerase II activity
AHA_3757	COG1289	transmembrane transporter activity
AHA_3758	COG1566	PFAM secretion protein HlyD family protein
AHA_3761	COG1051	belongs to the nudix hydrolase family
AHA_3762	COG3150	esterase
AHA_3764	COG3151	Protein conserved in bacteria
AHA_3765	COG0494	nUDIX hydrolase
AHA_3766	COG1538	Outer membrane efflux protein
AHA_3767	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AHA_3767	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AHA_3768	COG1560	Kdo2-lipid A biosynthetic process
AHA_3771	COG1392	Phosphate transport regulator
AHA_3772	COG0306	phosphate transporter
AHA_3773	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AHA_3779	COG0583	DNA-binding transcription factor activity
AHA_3780	COG1380	Effector of murein hydrolase LrgA
AHA_3781	COG1346	cytolysis
AHA_3784	COG0617	tRNA 3'-terminal CCA addition
AHA_3785	COG3409	Peptidoglycan-binding domain 1 protein
AHA_3785	COG3267	Type II secretory pathway component ExeA
AHA_3787	COG1194	a g-specific adenine glycosylase
AHA_3788	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AHA_3790	COG3111	PFAM Bacterial OB fold (BOF) protein
AHA_3791	COG3240	lipase activity
AHA_3793	COG2885	chlorophyll binding
AHA_3793	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AHA_3794	COG3009	Protein conserved in bacteria
AHA_3795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AHA_3795	COG3008	intermembrane lipid transfer
AHA_3796	COG2995	paraquat-inducible protein a
AHA_3798	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AHA_3800	COG4251	negative regulation of phosphorylation
AHA_3800	COG5001	Diguanylate cyclase
AHA_3800	COG3706	GGDEF domain
AHA_3800	COG2203	Gaf domain
AHA_3801	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AHA_3802	COG2813	Specifically methylates the guanine in position
AHA_3803	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AHA_3804	COG0297	glycogen (starch) synthase activity
AHA_3812	COG1757	Na H antiporter
AHA_3813	COG0583	DNA-binding transcription factor activity
AHA_3814	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AHA_3815	COG3842	ATPase activity
AHA_3816	COG1176	ABC-type spermidine putrescine transport system, permease component I
AHA_3817	COG1177	transmembrane transport
AHA_3818	COG1012	belongs to the aldehyde dehydrogenase family
AHA_3820	COG5006	permease, DMT superfamily
AHA_3821	COG1522	sequence-specific DNA binding
AHA_3822	COG0110	maltose O-acetyltransferase activity
AHA_3823	COG0366	Alpha amylase catalytic
AHA_3824	COG1263	PTS System
AHA_3824	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AHA_3828	COG0252	asparaginase activity
AHA_3831	COG1803	Methylglyoxal synthase
AHA_3837	COG1444	tRNA N-acetyltransferase activity
AHA_3838	COG0784	Response regulator, receiver
AHA_3838	COG0835	chemotaxis
AHA_3846	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AHA_3847	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AHA_3850	COG0477	Major facilitator Superfamily
AHA_3851	COG0523	cobalamin synthesis protein
AHA_3853	COG1280	lysine exporter protein (LysE YggA)
AHA_3855	COG2200	EAL domain
AHA_3856	COG1049	propionate catabolic process, 2-methylcitrate cycle
AHA_3857	COG1752	Esterase of the alpha-beta hydrolase superfamily
AHA_3858	COG0840	transmembrane signaling receptor activity
AHA_3859	COG0840	transmembrane signaling receptor activity
AHA_3861	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AHA_3862	COG0508	dehydrogenase complex catalyzes the overall conversion of
AHA_3863	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AHA_3864	COG2186	Transcriptional regulator
AHA_3869	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AHA_3870	COG1459	type II secretion system
AHA_3873	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AHA_3874	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AHA_3875	COG0494	nUDIX hydrolase
AHA_3877	COG0653	protein targeting
AHA_3879	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AHA_3880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AHA_3881	COG0849	cell division
AHA_3882	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AHA_3883	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AHA_3884	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AHA_3885	COG0772	Belongs to the SEDS family
AHA_3886	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AHA_3887	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AHA_3888	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AHA_3890	COG0768	penicillin binding
AHA_3891	COG3116	cell division
AHA_3892	COG0275	rRNA processing
AHA_3893	COG2001	Belongs to the MraZ family
AHA_3894	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AHA_3895	COG3107	peptidoglycan biosynthetic process
AHA_3896	COG0792	nuclease activity
AHA_3897	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AHA_3898	COG2823	Periplasmic or secreted lipoprotein
AHA_3899	COG2969	positive regulation of protein catabolic process
AHA_3900	COG0625	glutathione transferase activity
AHA_3901	COG2857	Cytochrome c1
AHA_3902	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AHA_3903	COG0723	plastoquinol--plastocyanin reductase activity
AHA_3904	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AHA_3905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AHA_3906	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AHA_3908	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AHA_3909	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AHA_3915	COG3964	amidohydrolase
AHA_3918	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_3918	COG3711	transcriptional antiterminator
AHA_3919	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_3920	COG1660	Displays ATPase and GTPase activities
AHA_3921	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AHA_3923	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AHA_3924	COG1137	ATPase activity
AHA_3925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AHA_3926	COG3117	lipopolysaccharide transmembrane transporter activity
AHA_3927	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AHA_3928	COG0517	IMP dehydrogenase activity
AHA_3928	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AHA_3929	COG1127	ABC transporter
AHA_3930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AHA_3931	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AHA_3932	COG2854	intermembrane phospholipid transfer
AHA_3934	COG5007	Belongs to the BolA IbaG family
AHA_3935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AHA_3936	COG0312	modulator of DNA gyrase
AHA_3937	COG3028	Belongs to the UPF0307 family
AHA_3939	COG2926	Belongs to the UPF0265 family
AHA_3946	COG1396	sequence-specific DNA binding
AHA_3947	COG3135	benzoate transporter
AHA_3952	COG0840	transmembrane signaling receptor activity
AHA_3953	COG3047	cAMP biosynthetic process
AHA_3954	COG3706	GGDEF domain
AHA_3955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AHA_3956	COG2197	response regulator
AHA_3957	COG0629	single-stranded DNA binding
AHA_3960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AHA_3962	COG1278	Cold shock
AHA_3963	COG4771	TonB-dependent receptor
AHA_3964	COG2203	Gaf domain
AHA_3964	COG3706	GGDEF domain
AHA_3964	COG5001	Diguanylate cyclase
AHA_3964	COG4251	negative regulation of phosphorylation
AHA_3966	COG0745	RESPONSE REGULATOR receiver
AHA_3972	COG0346	lactoylglutathione lyase activity
AHA_3974	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AHA_3975	COG1074	ATP-dependent DNA helicase activity
AHA_3976	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AHA_3977	COG2259	Doxx family
AHA_3978	COG1741	Belongs to the pirin family
AHA_3980	COG0583	DNA-binding transcription factor activity
AHA_3985	COG1175	transmembrane transport
AHA_3987	COG3842	ATPase activity
AHA_3989	COG3706	GGDEF domain
AHA_3993	COG1247	-acetyltransferase
AHA_3994	COG0753	catalase activity
AHA_3999	COG0494	nUDIX hydrolase
AHA_4000	COG0628	permease
AHA_4002	COG2957	Belongs to the agmatine deiminase family
AHA_4003	COG0583	DNA-binding transcription factor activity
AHA_4004	COG3284	Transcriptional regulator
AHA_4007	COG1461	Dihydroxyacetone kinase
AHA_4008	COG2376	Dihydroxyacetone kinase
AHA_4009	COG2252	PERMEase
AHA_4017	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AHA_4018	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AHA_4019	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AHA_4020	COG0049	tRNA binding
AHA_4021	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AHA_4022	COG2168	tRNA wobble position uridine thiolation
AHA_4023	COG2923	Belongs to the DsrF TusC family
AHA_4025	COG0251	oxidation-reduction process
AHA_4026	COG2964	Protein conserved in bacteria
AHA_4027	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AHA_4028	COG0085	RNA polymerase activity
AHA_4029	COG0222	ribosome binding
AHA_4030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AHA_4031	COG0081	regulation of translation
AHA_4032	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AHA_4033	COG0250	Participates in transcription elongation, termination and antitermination
AHA_4034	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AHA_4036	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AHA_4041	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AHA_4042	COG0569	domain protein
AHA_4043	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AHA_4047	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AHA_4048	COG3005	denitrification pathway
AHA_4049	COG0243	molybdopterin cofactor binding
AHA_4051	COG2205	protein histidine kinase activity
AHA_4052	COG0745	RESPONSE REGULATOR receiver
AHA_4055	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AHA_4059	COG2204	response regulator
AHA_4061	COG2205	protein histidine kinase activity
AHA_4064	COG5413	integral membrane protein
AHA_4067	COG1522	sequence-specific DNA binding
AHA_4068	COG2502	aspartate--ammonia ligase
AHA_4070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AHA_4071	COG0542	response to heat
AHA_4073	COG0564	pseudouridine synthase activity
AHA_4074	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AHA_4075	COG0446	pyridine nucleotide-disulphide oxidoreductase
AHA_4077	COG3681	Belongs to the UPF0597 family
AHA_4079	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AHA_4080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AHA_4081	COG1979	alcohol dehydrogenase
AHA_4082	COG2207	Transcriptional regulator
AHA_4084	COG0688	phosphatidylethanolamine metabolic process
AHA_4087	COG0540	Belongs to the ATCase OTCase family
AHA_4088	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AHA_4089	COG1438	arginine binding
AHA_4090	COG1288	antiporter activity
AHA_4091	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AHA_4097	COG0840	transmembrane signaling receptor activity
AHA_4101	COG3250	beta-galactosidase activity
AHA_4102	COG1609	Transcriptional regulator
AHA_4103	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AHA_4105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AHA_4106	COG2017	converts alpha-aldose to the beta-anomer
AHA_4107	COG0667	Aldo Keto reductase
AHA_4108	COG1968	undecaprenyl-diphosphatase activity
AHA_4109	COG3806	Anti-sigma factor
AHA_4110	COG1595	DNA-templated transcription, initiation
AHA_4114	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AHA_4115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AHA_4116	COG0477	Major facilitator Superfamily
AHA_4118	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AHA_4119	COG2146	nitrite reductase [NAD(P)H] activity
AHA_4120	COG2116	formate transmembrane transporter activity
AHA_4121	COG1648	precorrin-2 dehydrogenase activity
AHA_4121	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AHA_4122	COG2239	Acts as a magnesium transporter
AHA_4124	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AHA_4125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AHA_4127	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AHA_4129	COG0514	ATP-dependent DNA helicase (RecQ)
AHA_4130	COG2050	protein possibly involved in aromatic compounds catabolism
AHA_4133	COG2258	MOSC domain
AHA_4134	COG1177	transmembrane transport
AHA_4135	COG1176	ABC-type spermidine putrescine transport system, permease component I
AHA_4136	COG3842	ATPase activity
AHA_4140	COG0174	glutamine synthetase
AHA_4141	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AHA_4144	COG3045	CreA protein
AHA_4145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AHA_4146	COG0443	Heat shock 70 kDa protein
AHA_4149	COG0366	Alpha amylase catalytic
AHA_4150	COG1086	Polysaccharide biosynthesis protein
AHA_4151	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AHA_4152	COG1213	nucleotidyl transferase
AHA_4153	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AHA_4154	COG0574	Belongs to the PEP-utilizing enzyme family
AHA_4154	COG3848	Pyruvate phosphate dikinase
AHA_4155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AHA_4157	COG0529	Catalyzes the synthesis of activated sulfate
AHA_4162	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AHA_4166	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AHA_4170	COG1442	glycosyl transferase family 8
AHA_4171	COG1215	transferase activity, transferring glycosyl groups
AHA_4174	COG0318	PFAM AMP-dependent synthetase and ligase
AHA_4175	COG1028	Short-chain dehydrogenase reductase Sdr
AHA_4178	COG1083	cytidylyl-transferase
AHA_4180	COG2089	acid synthase
AHA_4183	COG4310	Domain of unknown function (DUF2172)
AHA_4191	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AHA_4192	COG0745	RESPONSE REGULATOR receiver
AHA_4193	COG2205	protein histidine kinase activity
AHA_4195	COG0281	malic enzyme
AHA_4196	COG0702	epimerase
AHA_4197	COG0254	rRNA binding
AHA_4198	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AHA_4202	COG0129	dihydroxy-acid dehydratase activity
AHA_4203	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AHA_4206	COG0606	chelatase, subunit chli
AHA_4207	COG0204	Acyl-transferase
AHA_4208	COG1683	Conserved Protein
AHA_4209	COG0204	Acyl-transferase
AHA_4211	COG1335	isochorismatase
AHA_4213	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AHA_4214	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AHA_4215	COG3639	organic phosphonate transmembrane transporter activity
AHA_4216	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AHA_4217	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AHA_4219	COG3084	Protein conserved in bacteria
AHA_4220	COG2203	Gaf domain
AHA_4220	COG3706	GGDEF domain
AHA_4220	COG4251	negative regulation of phosphorylation
AHA_4220	COG5001	Diguanylate cyclase
AHA_4221	COG0789	Transcriptional regulator
AHA_4223	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AHA_4224	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AHA_4225	COG1561	YicC-like family, N-terminal region
AHA_4229	COG3306	glycosyltransferase involved in LPS biosynthesis
AHA_4232	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AHA_4234	COG0156	8-amino-7-oxononanoate synthase activity
AHA_4235	COG1063	alcohol dehydrogenase
AHA_4236	COG3245	cytochrome
AHA_4238	COG0210	DNA helicase
AHA_4239	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AHA_4240	COG2166	iron-sulfur cluster assembly
AHA_4241	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AHA_4248	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AHA_4249	COG0848	biopolymer transport protein
AHA_4250	COG0811	peptide transport
AHA_4251	COG0811	peptide transport
AHA_4253	COG2771	luxR family
AHA_4254	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AHA_4255	COG1349	DNA-binding transcription factor activity
AHA_4256	COG0745	RESPONSE REGULATOR receiver
AHA_4257	COG2205	protein histidine kinase activity
AHA_4259	COG4452	Inner membrane protein CreD
AHA_4260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AHA_4261	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AHA_4262	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AHA_4263	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AHA_4264	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AHA_4265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AHA_4266	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AHA_4268	COG0356	it plays a direct role in the translocation of protons across the membrane
AHA_4270	COG1475	DNA binding
AHA_4271	COG1192	Involved in chromosome partitioning
AHA_4272	COG0357	Ribosomal RNA small subunit methyltransferase G
AHA_4273	COG0445	tRNA wobble uridine modification
AHA_4274	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AHA_4275	COG4774	siderophore transport
AHA_4276	COG4615	Cyclic peptide transporter
AHA_4277	COG1120	ATPase activity
AHA_4280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AHA_4281	COG0706	membrane insertase activity
AHA_4282	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AHA_4283	COG0594	ribonuclease P activity
AHA_4284	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AHA_4285	COG1126	abc transporter atp-binding protein