locus-tag	class	description
HQ398_00005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQ398_00010	COG0473	3-isopropylmalate dehydrogenase activity
HQ398_00040	COG0028	Belongs to the TPP enzyme family
HQ398_00045	COG0440	acetolactate synthase activity
HQ398_00090	COG3311	Transcriptional regulator
HQ398_00105	COG3385	transposase activity
HQ398_00150	COG2003	Belongs to the UPF0758 family
HQ398_00185	COG5002	protein histidine kinase activity
HQ398_00195	COG0745	RESPONSE REGULATOR receiver
HQ398_00205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HQ398_00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_00250	COG0745	RESPONSE REGULATOR receiver
HQ398_00255	COG3104	oligopeptide transport
HQ398_00260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HQ398_00265	COG1555	photosystem II stabilization
HQ398_00270	COG0857	belongs to the CobB CobQ family
HQ398_00270	COG0280	phosphate acetyltransferase
HQ398_00275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ398_00285	COG3013	Belongs to the UPF0304 family
HQ398_00290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQ398_00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ398_00305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HQ398_00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQ398_00345	COG0784	Response regulator, receiver
HQ398_00345	COG2198	Histidine kinase
HQ398_00345	COG5002	protein histidine kinase activity
HQ398_00380	COG1464	Belongs to the NlpA lipoprotein family
HQ398_00385	COG2011	ABC-type metal ion transport system permease component
HQ398_00390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HQ398_00410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQ398_00410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQ398_00415	COG0802	atpase or kinase
HQ398_00425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQ398_00430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQ398_00435	COG1923	regulation of RNA biosynthetic process
HQ398_00440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQ398_00445	COG0330	HflC and HflK could
HQ398_00450	COG0330	HflC and HflK could
HQ398_00455	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HQ398_00460	COG0142	geranyltranstransferase activity
HQ398_00465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQ398_00470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQ398_00475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQ398_00480	COG3314	Sporulation integral membrane protein YlbJ
HQ398_00485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ398_00495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQ398_00500	COG2967	ApaG domain
HQ398_00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQ398_00510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ398_00515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_00520	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HQ398_00525	COG3178	'Phosphotransferase
HQ398_00530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ398_00535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ398_00540	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_00545	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HQ398_00550	COG1073	alpha beta
HQ398_00565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQ398_00580	COG4628	conserved protein (DUF2132)
HQ398_00585	COG0688	phosphatidylethanolamine metabolic process
HQ398_00590	COG1162	GTPase activity
HQ398_00595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HQ398_00635	COG1278	Cold shock
HQ398_00645	COG0840	transmembrane signaling receptor activity
HQ398_00650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_00655	COG2252	PERMEase
HQ398_00665	COG0488	(ABC) transporter
HQ398_00670	COG0582	viral genome integration into host DNA
HQ398_00765	COG1846	Transcriptional regulator
HQ398_00865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HQ398_00915	COG2771	luxR family
HQ398_00950	COG4626	Terminase
HQ398_00950	COG1802	Transcriptional regulator
HQ398_01005	COG4386	tail sheath protein
HQ398_01050	COG3299	homolog of phage Mu protein gp47
HQ398_01055	COG3778	Protein conserved in bacteria
HQ398_01090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ398_01095	COG0741	lytic transglycosylase activity
HQ398_01105	COG3416	Protein conserved in bacteria
HQ398_01130	COG4608	Belongs to the ABC transporter superfamily
HQ398_01135	COG0444	Belongs to the ABC transporter superfamily
HQ398_01140	COG4239	(ABC) transporter, permease
HQ398_01145	COG4174	ABC transporter (Permease)
HQ398_01160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_01160	COG1902	pentaerythritol trinitrate reductase activity
HQ398_01165	COG0778	Nitroreductase
HQ398_01170	COG0110	maltose O-acetyltransferase activity
HQ398_01175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_01180	COG2264	protein methyltransferase activity
HQ398_01185	COG0604	alcohol dehydrogenase
HQ398_01190	COG0583	DNA-binding transcription factor activity
HQ398_01195	COG2190	(PTS) system
HQ398_01195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_01195	COG1263	PTS System
HQ398_01200	COG4145	pantothenate transmembrane transporter activity
HQ398_01205	COG3924	membrane
HQ398_01210	COG0439	Biotin carboxylase
HQ398_01215	COG0511	ligase activity, forming carbon-carbon bonds
HQ398_01220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQ398_01225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ398_01240	COG3385	transposase activity
HQ398_01255	COG3381	protein complex oligomerization
HQ398_01270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQ398_01280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQ398_01285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ398_01285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ398_01305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_01310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQ398_01315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HQ398_01325	COG4166	transmembrane transport
HQ398_01330	COG0601	transmembrane transport
HQ398_01340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQ398_01345	COG0142	geranyltranstransferase activity
HQ398_01350	COG1722	exodeoxyribonuclease VII activity
HQ398_01355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_01360	COG1360	Flagellar Motor Protein
HQ398_01360	COG1360	Flagellar Motor Protein
HQ398_01375	COG1534	Rna-binding protein
HQ398_01380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HQ398_01390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQ398_01395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ398_01400	COG0149	triose-phosphate isomerase activity
HQ398_01405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HQ398_01420	COG0779	Required for maturation of 30S ribosomal subunits
HQ398_01425	COG0195	Participates in both transcription termination and antitermination
HQ398_01430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQ398_01435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQ398_01440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQ398_01445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQ398_01450	COG1185	polyribonucleotide nucleotidyltransferase activity
HQ398_01455	COG2201	protein-glutamate methylesterase activity
HQ398_01460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HQ398_01485	COG0643	Histidine kinase
HQ398_01485	COG2198	Histidine kinase
HQ398_01495	COG0745	RESPONSE REGULATOR receiver
HQ398_01505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ398_01520	COG0826	peptidase U32
HQ398_01525	COG3385	transposase activity
HQ398_01530	COG0737	Belongs to the 5'-nucleotidase family
HQ398_01550	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HQ398_01575	COG0300	oxidoreductase activity
HQ398_01620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_01665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HQ398_01675	COG2003	Belongs to the UPF0758 family
HQ398_01720	COG5377	YqaJ viral recombinase family
HQ398_01750	COG0077	Prephenate dehydratase
HQ398_01750	COG1605	Chorismate mutase
HQ398_01780	COG3272	Protein of unknown function (DUF1722)
HQ398_01785	COG0789	Transcriptional regulator
HQ398_01790	COG0415	Belongs to the DNA photolyase family
HQ398_01800	COG0300	oxidoreductase activity
HQ398_01815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ398_01845	COG1477	protein flavinylation
HQ398_01850	COG2871	sodium ion transport
HQ398_01855	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_01860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_01865	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_01870	COG1805	sodium ion transport
HQ398_01875	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_01880	COG0271	Belongs to the BolA IbaG family
HQ398_01885	COG2813	Specifically methylates the guanine in position
HQ398_01895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ398_01910	COG1666	GTP binding
HQ398_01915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HQ398_01930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_01935	COG0840	transmembrane signaling receptor activity
HQ398_01940	COG0583	DNA-binding transcription factor activity
HQ398_01950	COG2363	Small membrane protein
HQ398_01955	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HQ398_01965	COG0473	3-isopropylmalate dehydrogenase activity
HQ398_01970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ398_01975	COG1611	Belongs to the LOG family
HQ398_01990	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ398_01990	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ398_02000	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HQ398_02025	COG3098	single-species biofilm formation
HQ398_02030	COG0564	pseudouridine synthase activity
HQ398_02045	COG3385	transposase activity
HQ398_02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_02060	COG1263	PTS System
HQ398_02070	COG2171	N-acyltransferase activity
HQ398_02080	COG0024	Methionine aminopeptidase
HQ398_02085	COG0052	Belongs to the universal ribosomal protein uS2 family
HQ398_02090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQ398_02095	COG0528	UMP kinase activity
HQ398_02100	COG0233	cytoplasmic translational termination
HQ398_02105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HQ398_02110	COG0575	Belongs to the CDS family
HQ398_02115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQ398_02120	COG0750	zinc metalloprotease
HQ398_02125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_02135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_02140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_02145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_02150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_02155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQ398_02165	COG0825	malonyl-CoA metabolic process
HQ398_02175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ398_02180	COG1115	amino acid carrier protein
HQ398_02230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQ398_02235	COG1678	Uncharacterized ACR, COG1678
HQ398_02245	COG0189	ligase activity
HQ398_02250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQ398_02260	COG3091	SprT-like family
HQ398_02270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HQ398_02285	COG3385	transposase activity
HQ398_02300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HQ398_02305	COG0739	heme binding
HQ398_02310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ398_02340	COG0814	amino acid
HQ398_02370	COG0488	(ABC) transporter
HQ398_02375	COG3710	Transcriptional regulator
HQ398_02380	COG0531	amino acid
HQ398_02385	COG1982	Orn Lys Arg decarboxylase major
HQ398_02390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ398_02400	COG3590	peptidase
HQ398_02410	COG2199	diguanylate cyclase activity
HQ398_02410	COG2203	Gaf domain
HQ398_02445	COG0366	Alpha amylase catalytic
HQ398_02460	COG0463	Glycosyl transferase, family 2
HQ398_02475	COG2989	Protein conserved in bacteria
HQ398_02480	COG3108	Peptidase M15
HQ398_02490	COG2860	membrane
HQ398_02500	COG1196	nuclear chromosome segregation
HQ398_02505	COG3115	cell septum assembly
HQ398_02510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ398_02520	COG1328	CTP reductase activity
HQ398_02525	COG0602	queuosine metabolic process
HQ398_02570	COG0281	malic enzyme
HQ398_02575	COG3290	protein histidine kinase activity
HQ398_02585	COG0697	spore germination
HQ398_02595	COG3706	GGDEF domain
HQ398_02600	COG0346	lactoylglutathione lyase activity
HQ398_02605	COG0745	RESPONSE REGULATOR receiver
HQ398_02610	COG5002	protein histidine kinase activity
HQ398_02635	COG3142	Participates in the control of copper homeostasis
HQ398_02640	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ398_02655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HQ398_02675	COG0019	diaminopimelate decarboxylase activity
HQ398_02680	COG1115	amino acid carrier protein
HQ398_02700	COG0534	Mate efflux family protein
HQ398_02710	COG0281	malic enzyme
HQ398_02720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HQ398_02720	COG2885	chlorophyll binding
HQ398_02740	COG0733	neurotransmitter:sodium symporter activity
HQ398_02745	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ398_02750	COG3706	GGDEF domain
HQ398_02755	COG1566	PFAM secretion protein HlyD family protein
HQ398_02765	COG1032	radical SAM domain protein
HQ398_02800	COG0583	DNA-binding transcription factor activity
HQ398_02810	COG0673	inositol 2-dehydrogenase activity
HQ398_02815	COG2920	part of a sulfur-relay system
HQ398_02820	COG1289	transmembrane transporter activity
HQ398_02825	COG0670	Belongs to the BI1 family
HQ398_02840	COG1486	melibiose metabolic process
HQ398_02845	COG2169	Transcriptional regulator
HQ398_02845	COG1917	Cupin 2, conserved barrel domain protein
HQ398_02850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HQ398_02855	COG2723	6-phospho-beta-galactosidase activity
HQ398_02860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HQ398_02865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HQ398_02875	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HQ398_02885	COG3156	type II secretion system protein K
HQ398_02890	COG4795	General secretion pathway protein
HQ398_02895	COG2165	general secretion pathway protein
HQ398_02905	COG2165	general secretion pathway protein
HQ398_02910	COG1459	type II secretion system
HQ398_02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_02925	COG3031	protein transport across the cell outer membrane
HQ398_02935	COG3267	Type II secretory pathway component ExeA
HQ398_02935	COG3409	Peptidoglycan-binding domain 1 protein
HQ398_02940	COG2770	Histidine kinase
HQ398_02940	COG3437	response regulator, receiver
HQ398_02955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQ398_02960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HQ398_02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_02975	COG2190	(PTS) system
HQ398_02980	COG3706	GGDEF domain
HQ398_02985	COG3264	Mechanosensitive ion channel
HQ398_02985	COG1196	nuclear chromosome segregation
HQ398_02990	COG0469	pyruvate kinase activity
HQ398_03000	COG3384	dioxygenase
HQ398_03005	COG0419	ATPase involved in DNA repair
HQ398_03010	COG0420	3'-5' exonuclease activity
HQ398_03020	COG2974	May be involved in recombination
HQ398_03030	COG1283	sodium-dependent phosphate transmembrane transporter activity
HQ398_03040	COG0531	amino acid
HQ398_03050	COG0531	amino acid
HQ398_03065	COG1917	Cupin 2, conserved barrel domain protein
HQ398_03065	COG1396	sequence-specific DNA binding
HQ398_03070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_03095	COG3152	Membrane
HQ398_03100	COG3385	transposase activity
HQ398_03105	COG3161	chorismate lyase activity
HQ398_03150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HQ398_03155	COG4988	ABC transporter
HQ398_03170	COG0745	RESPONSE REGULATOR receiver
HQ398_03180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ398_03195	COG0640	Transcriptional regulator
HQ398_03200	COG0798	PFAM Bile acid sodium symporter
HQ398_03210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_03215	COG1988	membrane-bound metal-dependent
HQ398_03225	COG3385	transposase activity
HQ398_03235	COG0159	tryptophan synthase activity
HQ398_03240	COG0133	tryptophan synthase activity
HQ398_03245	COG0135	phosphoribosylanthranilate isomerase activity
HQ398_03245	COG0134	indole-3-glycerol-phosphate synthase activity
HQ398_03250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ398_03255	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ398_03255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ398_03260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQ398_03270	COG0009	L-threonylcarbamoyladenylate synthase
HQ398_03280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HQ398_03295	COG3210	domain, Protein
HQ398_03320	COG1993	acr, cog1993
HQ398_03335	COG1946	Acyl-CoA thioesterase
HQ398_03340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HQ398_03345	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HQ398_03360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ398_03380	COG0813	purine-nucleoside phosphorylase activity
HQ398_03405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ398_03430	COG1309	transcriptional regulator
HQ398_03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_03450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HQ398_03475	COG1216	Glycosyl transferase, family 2
HQ398_03490	COG3594	Acyltransferase
HQ398_03505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HQ398_03510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_03535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ398_03540	COG1091	dTDP-4-dehydrorhamnose reductase activity
HQ398_03560	COG3385	transposase activity
HQ398_03565	COG1538	Outer membrane efflux protein
HQ398_03570	COG1136	(ABC) transporter
HQ398_03570	COG0577	efflux transmembrane transporter activity
HQ398_03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_03580	COG1227	inorganic diphosphatase activity
HQ398_03585	COG0497	DNA recombination
HQ398_03590	COG1486	melibiose metabolic process
HQ398_03595	COG0583	DNA-binding transcription factor activity
HQ398_03600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQ398_03605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQ398_03610	COG0443	Heat shock 70 kDa protein
HQ398_03615	COG0484	heat shock protein binding
HQ398_03660	COG5001	Diguanylate cyclase
HQ398_03665	COG0095	Lipoate-protein ligase
HQ398_03675	COG0702	epimerase
HQ398_03680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_03685	COG1454	alcohol dehydrogenase
HQ398_03695	COG0564	pseudouridine synthase activity
HQ398_03700	COG1957	nucleoside hydrolase
HQ398_03730	COG1280	lysine exporter protein (LysE YggA)
HQ398_03735	COG3263	regulation of cellular component size
HQ398_03745	COG3263	regulation of cellular component size
HQ398_03755	COG1876	peptidase activity
HQ398_03760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ398_03765	COG1393	Belongs to the ArsC family
HQ398_03775	COG3385	transposase activity
HQ398_03780	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_03785	COG1473	amidohydrolase
HQ398_03795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ398_03805	COG0017	Asparaginyl-tRNA synthetase
HQ398_03820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HQ398_03825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ398_03830	COG0156	8-amino-7-oxononanoate synthase activity
HQ398_03835	COG1073	alpha beta
HQ398_03835	COG2226	methyltransferase
HQ398_03840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQ398_03845	COG0501	Belongs to the peptidase M48B family
HQ398_03850	COG0633	Ferredoxin
HQ398_03850	COG3217	Mosc domain protein beta barrel domain protein
HQ398_03850	COG0633	Ferredoxin
HQ398_03850	COG3217	Mosc domain protein beta barrel domain protein
HQ398_03860	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ398_03860	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ398_03860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ398_03860	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HQ398_03870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_03875	COG1607	acyl-coa hydrolase
HQ398_03885	COG3021	interspecies interaction between organisms
HQ398_03890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HQ398_03895	COG2027	D-alanyl-D-alanine carboxypeptidase
HQ398_03900	COG1061	Type III restriction enzyme res subunit
HQ398_03905	COG1566	PFAM secretion protein HlyD family protein
HQ398_03915	COG1966	Carbon starvation protein
HQ398_03920	COG3279	Response regulator of the LytR AlgR family
HQ398_03930	COG2199	diguanylate cyclase activity
HQ398_03930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_03940	COG1846	Transcriptional regulator
HQ398_03940	COG1940	carbohydrate kinase activity
HQ398_03945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_03950	COG0363	glucosamine-6-phosphate deaminase activity
HQ398_03955	COG1263	PTS System
HQ398_03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_03955	COG2190	(PTS) system
HQ398_03965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_03970	COG0735	belongs to the Fur family
HQ398_03980	COG0716	FMN binding
HQ398_04000	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HQ398_04005	COG0033	Phosphoglucomutase
HQ398_04010	COG2951	lytic endotransglycosylase activity
HQ398_04015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQ398_04020	COG4136	ATPase activity
HQ398_04030	COG4134	Bacterial extracellular solute-binding protein
HQ398_04040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ398_04050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_04060	COG0729	surface antigen
HQ398_04085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HQ398_04095	COG0741	lytic transglycosylase activity
HQ398_04105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_04110	COG4771	TonB-dependent receptor
HQ398_04115	COG1169	isochorismate synthase
HQ398_04120	COG1021	2,3-dihydroxybenzoate-AMP ligase
HQ398_04125	COG3433	isochorismatase activity
HQ398_04125	COG1535	isochorismatase
HQ398_04130	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_04160	COG1278	Cold shock
HQ398_04195	COG1349	DNA-binding transcription factor activity
HQ398_04200	COG1882	Formate acetyltransferase
HQ398_04205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_04210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ398_04235	COG4166	transmembrane transport
HQ398_04240	COG0622	Phosphoesterase
HQ398_04255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HQ398_04260	COG0835	chemotaxis
HQ398_04260	COG0784	Response regulator, receiver
HQ398_04265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQ398_04270	COG1815	bacterial-type flagellum-dependent cell motility
HQ398_04280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HQ398_04290	COG4787	bacterial-type flagellum-dependent cell motility
HQ398_04300	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ398_04305	COG1706	bacterial-type flagellum-dependent cell motility
HQ398_04310	COG3951	Flagellar rod assembly protein muramidase FlgJ
HQ398_04310	COG1705	Flagellar rod assembly protein muramidase FlgJ
HQ398_04325	COG2239	Acts as a magnesium transporter
HQ398_04335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ398_04340	COG2716	regulation of RNA biosynthetic process
HQ398_04365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQ398_04370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQ398_04375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQ398_04380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQ398_04400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQ398_04420	COG0590	tRNA wobble adenosine to inosine editing
HQ398_04425	COG0573	inorganic phosphate transmembrane transporter activity
HQ398_04430	COG0581	inorganic phosphate transmembrane transporter activity
HQ398_04435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQ398_04440	COG0704	Plays a role in the regulation of phosphate uptake
HQ398_04445	COG1253	flavin adenine dinucleotide binding
HQ398_04465	COG1126	abc transporter atp-binding protein
HQ398_04470	COG0765	amino acid transport
HQ398_04475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_04480	COG2199	diguanylate cyclase activity
HQ398_04480	COG2203	Gaf domain
HQ398_04495	COG2197	response regulator
HQ398_04500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ398_04525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HQ398_04530	COG0477	Major facilitator Superfamily
HQ398_04535	COG0123	including yeast histone deacetylase and acetoin utilization protein
HQ398_04545	COG1199	ATP-dependent helicase activity
HQ398_04555	COG0287	Prephenate dehydrogenase
HQ398_04555	COG1605	Chorismate mutase
HQ398_04560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_04570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_04575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_04610	COG0537	adenosine 5'-monophosphoramidase activity
HQ398_04625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ398_04640	COG1301	dicarboxylic acid transport
HQ398_04655	COG1164	Oligoendopeptidase f
HQ398_04660	COG2233	PERMEase
HQ398_04665	COG3150	esterase
HQ398_04670	COG1252	NADH dehydrogenase
HQ398_04680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_04705	COG4953	penicillin-binding protein 1C
HQ398_04715	COG0301	tRNA thio-modification
HQ398_04715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_04730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_04775	COG2089	acid synthase
HQ398_04785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ398_04790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ398_04800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ398_04805	COG1086	Polysaccharide biosynthesis protein
HQ398_04810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ398_04820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ398_04835	COG0483	inositol monophosphate 1-phosphatase activity
HQ398_04845	COG0625	glutathione transferase activity
HQ398_04850	COG2814	Major facilitator Superfamily
HQ398_04860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ398_04865	COG0243	molybdopterin cofactor binding
HQ398_04885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_04890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_04895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQ398_04900	COG0509	glycine decarboxylation via glycine cleavage system
HQ398_04905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ398_04905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ398_04915	COG5642	Protein of unknown function (DUF2384)
HQ398_04935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ398_04945	COG0840	transmembrane signaling receptor activity
HQ398_04970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HQ398_04975	COG0574	Belongs to the PEP-utilizing enzyme family
HQ398_04975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HQ398_04990	COG1464	Belongs to the NlpA lipoprotein family
HQ398_04995	COG3083	sulfuric ester hydrolase activity
HQ398_05000	COG3082	Protein of unknown function (DUF1414)
HQ398_05005	COG3081	Nucleoid-associated protein
HQ398_05015	COG1175	transmembrane transport
HQ398_05020	COG3833	ABC-type maltose transport systems, permease component
HQ398_05025	COG3842	ATPase activity
HQ398_05050	COG0425	Belongs to the sulfur carrier protein TusA family
HQ398_05055	COG4783	chaperone-mediated protein folding
HQ398_05065	COG1393	Belongs to the ArsC family
HQ398_05080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_05085	COG2431	L-lysine efflux transmembrane transporter activity
HQ398_05105	COG4160	amino acid transport
HQ398_05110	COG0564	pseudouridine synthase activity
HQ398_05135	COG0625	glutathione transferase activity
HQ398_05140	COG0367	asparagine synthase
HQ398_05150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQ398_05150	COG4651	solute:proton antiporter activity
HQ398_05155	COG0647	UMP catabolic process
HQ398_05170	COG1902	pentaerythritol trinitrate reductase activity
HQ398_05185	COG0247	lactate metabolic process
HQ398_05185	COG0277	FAD linked oxidase domain protein
HQ398_05195	COG2050	protein possibly involved in aromatic compounds catabolism
HQ398_05210	COG5001	Diguanylate cyclase
HQ398_05210	COG3300	MHYT domain
HQ398_05215	COG2056	Na+-H+ antiporter family
HQ398_05220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ398_05225	COG0671	phosphoesterase, PA-phosphatase related
HQ398_05235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ398_05245	COG0101	tRNA pseudouridine synthase activity
HQ398_05250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQ398_05255	COG0285	dihydrofolate synthase activity
HQ398_05260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HQ398_05265	COG0393	Putative heavy-metal-binding
HQ398_05275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_05275	COG1648	precorrin-2 dehydrogenase activity
HQ398_05295	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ398_05300	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ398_05305	COG1368	sulfuric ester hydrolase activity
HQ398_05315	COG0527	aspartate kinase activity
HQ398_05325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ398_05345	COG0596	Alpha beta hydrolase
HQ398_05350	COG0840	transmembrane signaling receptor activity
HQ398_05385	COG0672	)-iron permease
HQ398_05420	COG0659	secondary active sulfate transmembrane transporter activity
HQ398_05435	COG3501	Rhs element vgr protein
HQ398_05455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQ398_05460	COG0326	Molecular chaperone. Has ATPase activity
HQ398_05465	COG4172	Belongs to the ABC transporter superfamily
HQ398_05495	COG1842	Phage shock protein A
HQ398_05515	COG3768	UPF0283 membrane protein
HQ398_05525	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQ398_05540	COG2199	diguanylate cyclase activity
HQ398_05545	COG2885	chlorophyll binding
HQ398_05550	COG0861	Integral membrane protein TerC family
HQ398_05565	COG1022	Amp-dependent synthetase and ligase
HQ398_05580	COG2910	NAD(P)H-binding
HQ398_05585	COG0583	DNA-binding transcription factor activity
HQ398_05590	COG0583	DNA-binding transcription factor activity
HQ398_05595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HQ398_05610	COG0583	DNA-binding transcription factor activity
HQ398_05615	COG2723	6-phospho-beta-galactosidase activity
HQ398_05620	COG1944	ATP diphosphatase activity
HQ398_05625	COG2116	formate transmembrane transporter activity
HQ398_05630	COG1882	Formate acetyltransferase
HQ398_05635	COG2983	Belongs to the UPF0260 family
HQ398_05650	COG0058	SHG alpha-glucan phosphorylase activity
HQ398_05655	COG0471	metal ion transport
HQ398_05660	COG3118	belongs to the thioredoxin family
HQ398_05665	COG3850	Histidine kinase
HQ398_05665	COG2205	protein histidine kinase activity
HQ398_05665	COG4999	Histidine kinase
HQ398_05665	COG3437	response regulator, receiver
HQ398_05670	COG1132	(ABC) transporter
HQ398_05675	COG1132	(ABC) transporter
HQ398_05685	COG2501	S4 domain
HQ398_05700	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ398_05740	COG2009	succinate dehydrogenase
HQ398_05745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HQ398_05750	COG1053	succinate dehydrogenase
HQ398_05760	COG0567	Dehydrogenase, E1 component
HQ398_05765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ398_05770	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ398_05800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_05810	COG3842	ATPase activity
HQ398_05820	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ398_05830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HQ398_05840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_05845	COG3088	subunit of a heme lyase
HQ398_05845	COG4235	cytochrome complex assembly
HQ398_05865	COG0437	4 iron, 4 sulfur cluster binding
HQ398_05870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HQ398_05890	COG0247	lactate metabolic process
HQ398_05895	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HQ398_05900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQ398_05915	COG0840	transmembrane signaling receptor activity
HQ398_05920	COG1940	carbohydrate kinase activity
HQ398_05920	COG1846	Transcriptional regulator
HQ398_05925	COG3148	PFAM DTW domain containing protein
HQ398_05930	COG0730	response to heat
HQ398_05935	COG0583	DNA-binding transcription factor activity
HQ398_05950	COG3593	DNA synthesis involved in DNA repair
HQ398_05995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_06000	COG1011	Hydrolase
HQ398_06015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ398_06020	COG2832	Protein of unknown function (DUF454)
HQ398_06025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQ398_06035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQ398_06050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HQ398_06055	COG0583	DNA-binding transcription factor activity
HQ398_06065	COG1560	Kdo2-lipid A biosynthetic process
HQ398_06070	COG1560	Kdo2-lipid A biosynthetic process
HQ398_06090	COG0417	DNA replication proofreading
HQ398_06105	COG1451	nucleotide metabolic process
HQ398_06120	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_06135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HQ398_06135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_06140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ398_06170	COG0586	Pfam SNARE associated Golgi protein
HQ398_06175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ398_06180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ398_06205	COG3829	transcription factor binding
HQ398_06235	COG0534	Mate efflux family protein
HQ398_06250	COG0307	riboflavin synthase, alpha
HQ398_06265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_06270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HQ398_06275	COG0697	spore germination
HQ398_06280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ398_06320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ398_06325	COG3099	Belongs to the UPF0263 family
HQ398_06330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HQ398_06335	COG2894	cell division
HQ398_06340	COG0850	regulation of cytokinetic process
HQ398_06345	COG3100	YcgL domain-containing protein
HQ398_06350	COG3385	transposase activity
HQ398_06360	COG2824	Alkylphosphonate utilization operon protein PhnA
HQ398_06375	COG3791	Glutathione-dependent formaldehyde-activating
HQ398_06380	COG0406	alpha-ribazole phosphatase activity
HQ398_06385	COG3706	GGDEF domain
HQ398_06390	COG2840	Smr protein MutS2
HQ398_06395	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ398_06400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQ398_06410	COG0513	Belongs to the DEAD box helicase family
HQ398_06415	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HQ398_06430	COG0814	amino acid
HQ398_06435	COG1609	Transcriptional regulator
HQ398_06440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_06440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_06445	COG1105	Belongs to the carbohydrate kinase PfkB family
HQ398_06450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_06450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_06450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HQ398_06455	COG2140	Oxalate decarboxylase
HQ398_06475	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_06475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_06485	COG3716	PTS system mannose fructose sorbose family IID component
HQ398_06495	COG3313	Fe-S protein
HQ398_06500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HQ398_06505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_06510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ398_06515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ398_06525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ398_06535	COG0366	Alpha amylase catalytic
HQ398_06555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQ398_06560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQ398_06565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQ398_06570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQ398_06575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ398_06580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQ398_06585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_06585	COG0072	phenylalanine-tRNA ligase activity
HQ398_06590	COG0776	regulation of translation
HQ398_06595	COG2205	protein histidine kinase activity
HQ398_06595	COG0784	Response regulator, receiver
HQ398_06615	COG1609	Transcriptional regulator
HQ398_06620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_06625	COG1879	ABC-type sugar transport system periplasmic component
HQ398_06630	COG1172	Belongs to the binding-protein-dependent transport system permease family
HQ398_06635	COG1129	ABC transporter
HQ398_06640	COG1869	D-ribose catabolic process
HQ398_06645	COG0625	glutathione transferase activity
HQ398_06655	COG1177	transmembrane transport
HQ398_06680	COG0037	tRNA processing
HQ398_06685	COG0589	response to stress
HQ398_06690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_06715	COG2010	Cytochrome c
HQ398_06730	COG3278	Belongs to the heme-copper respiratory oxidase family
HQ398_06740	COG1956	GAF domain-containing protein
HQ398_06745	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HQ398_06755	COG0308	aminopeptidase N
HQ398_06765	COG2902	Dehydrogenase
HQ398_06770	COG0167	dihydroorotate dehydrogenase activity
HQ398_06795	COG3706	GGDEF domain
HQ398_06795	COG4251	negative regulation of phosphorylation
HQ398_06795	COG5001	Diguanylate cyclase
HQ398_06795	COG2203	Gaf domain
HQ398_06800	COG2201	protein-glutamate methylesterase activity
HQ398_06810	COG0835	chemotaxis
HQ398_06835	COG0116	Belongs to the methyltransferase superfamily
HQ398_06835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ398_06845	COG0488	(ABC) transporter
HQ398_06855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_06860	COG1067	ATP-dependent peptidase activity
HQ398_06875	COG3141	response to X-ray
HQ398_06885	COG4221	oxidoreductase activity
HQ398_06910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ398_06930	COG0372	Belongs to the citrate synthase family
HQ398_06935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HQ398_06945	COG2995	paraquat-inducible protein a
HQ398_06950	COG3008	intermembrane lipid transfer
HQ398_06955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_06955	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HQ398_06970	COG0084	hydrolase, TatD family'
HQ398_06975	COG0470	DNA polymerase III
HQ398_06980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HQ398_06985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQ398_06990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQ398_07000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ398_07005	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_07015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ398_07020	COG0416	fatty acid biosynthetic process
HQ398_07025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQ398_07030	COG1399	metal-binding, possibly nucleic acid-binding protein
HQ398_07035	COG0424	maF-like protein
HQ398_07040	COG3385	transposase activity
HQ398_07055	COG1530	ribonuclease E activity
HQ398_07065	COG0306	phosphate transporter
HQ398_07070	COG0717	Belongs to the dCTP deaminase family
HQ398_07075	COG0572	uridine kinase
HQ398_07080	COG0489	protein tyrosine kinase activity
HQ398_07085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_07085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_07095	COG1254	Belongs to the acylphosphatase family
HQ398_07105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ398_07115	COG0709	Synthesizes selenophosphate from selenide and ATP
HQ398_07120	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HQ398_07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ398_07135	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_07140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ398_07150	COG1214	PFAM Peptidase M22, glycoprotease
HQ398_07155	COG1199	ATP-dependent helicase activity
HQ398_07165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQ398_07170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ398_07175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ398_07180	COG0131	Imidazoleglycerol-phosphate dehydratase
HQ398_07180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ398_07185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQ398_07190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQ398_07195	COG0107	imidazoleglycerol-phosphate synthase activity
HQ398_07210	COG2199	diguanylate cyclase activity
HQ398_07220	COG1288	antiporter activity
HQ398_07230	COG3134	Outer membrane lipoprotein
HQ398_07235	COG2080	2 iron, 2 sulfur cluster binding
HQ398_07240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ398_07245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ398_07255	COG2252	PERMEase
HQ398_07260	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_07270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ398_07270	COG2080	2 iron, 2 sulfur cluster binding
HQ398_07275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ398_07280	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_07285	COG0493	'glutamate synthase
HQ398_07285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_07295	COG2068	MobA-Related Protein
HQ398_07300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ398_07305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQ398_07305	COG3608	succinylglutamate desuccinylase aspartoacylase
HQ398_07310	COG0697	spore germination
HQ398_07315	COG0549	Belongs to the carbamate kinase family
HQ398_07325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ398_07330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ398_07335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ398_07360	COG0242	peptide deformylase activity
HQ398_07370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQ398_07375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HQ398_07380	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HQ398_07390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ398_07395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HQ398_07405	COG0205	6-phosphofructokinase activity
HQ398_07410	COG1301	dicarboxylic acid transport
HQ398_07415	COG3123	guanosine phosphorylase activity
HQ398_07420	COG1760	l-serine dehydratase
HQ398_07425	COG1760	l-serine dehydratase
HQ398_07445	COG0814	amino acid
HQ398_07450	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HQ398_07455	COG0514	ATP-dependent DNA helicase (RecQ)
HQ398_07460	COG2766	serine protein kinase
HQ398_07465	COG2718	Belongs to the UPF0229 family
HQ398_07470	COG2719	SpoVR family
HQ398_07475	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ398_07475	COG1024	Enoyl-CoA hydratase
HQ398_07480	COG0183	Belongs to the thiolase family
HQ398_07485	COG0714	Associated with various cellular activities
HQ398_07515	COG1595	DNA-templated transcription, initiation
HQ398_07525	COG2067	long-chain fatty acid transport protein
HQ398_07530	COG2067	long-chain fatty acid transport protein
HQ398_07535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HQ398_07550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQ398_07560	COG1643	Atp-dependent helicase
HQ398_07565	COG0517	IMP dehydrogenase activity
HQ398_07565	COG0617	tRNA 3'-terminal CCA addition
HQ398_07565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQ398_07570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_07575	COG2925	Exonuclease
HQ398_07585	COG3345	alpha-galactosidase
HQ398_07590	COG1380	Effector of murein hydrolase LrgA
HQ398_07595	COG1346	cytolysis
HQ398_07600	COG0295	cytidine deaminase activity
HQ398_07605	COG3033	Beta-eliminating lyase
HQ398_07615	COG3046	protein related to deoxyribodipyrimidine photolyase
HQ398_07625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ398_07650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_07655	COG3385	transposase activity
HQ398_07670	COG0454	-acetyltransferase
HQ398_07675	COG3158	transport of potassium into the cell
HQ398_07680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_07685	COG0651	ATP synthesis coupled electron transport
HQ398_07690	COG0650	Formate hydrogenlyase subunit 4
HQ398_07695	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HQ398_07695	COG3261	NADH dehydrogenase
HQ398_07700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_07705	COG3260	NADH ubiquinone oxidoreductase 20
HQ398_07715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HQ398_07725	COG1921	L-seryl-tRNASec selenium transferase activity
HQ398_07735	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HQ398_07740	COG0298	carbon dioxide binding
HQ398_07755	COG0375	protein maturation
HQ398_07760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HQ398_07765	COG3842	ATPase activity
HQ398_07775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ398_07790	COG1773	rubredoxin
HQ398_07795	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HQ398_07800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HQ398_07805	COG5557	Pfam Polysulphide reductase, NrfD
HQ398_07810	COG0437	4 iron, 4 sulfur cluster binding
HQ398_07815	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HQ398_07850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HQ398_07865	COG2003	Belongs to the UPF0758 family
HQ398_07900	COG3385	transposase activity
HQ398_07910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HQ398_07930	COG0730	response to heat
HQ398_07950	COG1024	Enoyl-CoA hydratase
HQ398_07955	COG1024	Enoyl-CoA hydratase
HQ398_07960	COG1960	acyl-CoA dehydrogenase activity
HQ398_07965	COG1960	acyl-CoA dehydrogenase activity
HQ398_07970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQ398_07975	COG1024	Enoyl-CoA hydratase
HQ398_08005	COG1584	GPR1 FUN34 yaaH family protein
HQ398_08010	COG3228	Belongs to the MtfA family
HQ398_08020	COG1115	amino acid carrier protein
HQ398_08025	COG1024	Enoyl-CoA hydratase
HQ398_08040	COG3162	membrane
HQ398_08045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ398_08050	COG0488	(ABC) transporter
HQ398_08055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_08060	COG0776	regulation of translation
HQ398_08065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HQ398_08070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQ398_08075	COG0740	serine-type endopeptidase activity
HQ398_08080	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQ398_08090	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HQ398_08095	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ398_08100	COG1136	(ABC) transporter
HQ398_08105	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ398_08115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQ398_08120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQ398_08125	COG4166	transmembrane transport
HQ398_08130	COG0697	spore germination
HQ398_08140	COG2062	phosphohistidine phosphatase, SixA
HQ398_08170	COG3385	transposase activity
HQ398_08180	COG0519	Catalyzes the synthesis of GMP from XMP
HQ398_08180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ398_08185	COG0517	IMP dehydrogenase activity
HQ398_08185	COG0516	GMP reductase activity
HQ398_08200	COG3158	transport of potassium into the cell
HQ398_08220	COG1570	exodeoxyribonuclease VII activity
HQ398_08225	COG2188	Transcriptional regulator
HQ398_08230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_08230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_08230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_08235	COG0383	alpha-mannosidase activity
HQ398_08240	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQ398_08250	COG0386	Belongs to the glutathione peroxidase family
HQ398_08255	COG0513	Belongs to the DEAD box helicase family
HQ398_08270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HQ398_08345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_08355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ398_08360	COG0563	adenylate kinase activity
HQ398_08370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HQ398_08375	COG1286	toxin biosynthetic process
HQ398_08380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQ398_08390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HQ398_08395	COG0531	amino acid
HQ398_08395	COG1674	ftsk spoiiie
HQ398_08410	COG0492	ferredoxin-NADP+ reductase activity
HQ398_08415	COG3706	GGDEF domain
HQ398_08420	COG3134	Outer membrane lipoprotein
HQ398_08425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQ398_08430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HQ398_08435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQ398_08440	COG0542	response to heat
HQ398_08445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HQ398_08450	COG1278	Cold shock
HQ398_08455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQ398_08475	COG0745	RESPONSE REGULATOR receiver
HQ398_08480	COG2205	protein histidine kinase activity
HQ398_08490	COG0392	lysyltransferase activity
HQ398_08490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HQ398_08500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ398_08530	COG1435	thymidine kinase activity
HQ398_08535	COG1757	Na H antiporter
HQ398_08540	COG2916	Histone family protein nucleoid-structuring protein H-NS
HQ398_08545	COG2096	Adenosyltransferase
HQ398_08550	COG3530	Putative quorum-sensing-regulated virulence factor
HQ398_08555	COG0602	queuosine metabolic process
HQ398_08560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HQ398_08580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HQ398_08590	COG0776	regulation of translation
HQ398_08595	COG0539	negative regulation of cytoplasmic translation
HQ398_08600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQ398_08605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ398_08620	COG2814	Major facilitator Superfamily
HQ398_08640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HQ398_08645	COG5001	Diguanylate cyclase
HQ398_08645	COG3300	MHYT domain
HQ398_08650	COG0583	DNA-binding transcription factor activity
HQ398_08655	COG3437	response regulator, receiver
HQ398_08680	COG4989	oxidoreductase activity
HQ398_08685	COG0724	RNA recognition motif
HQ398_08695	COG1126	abc transporter atp-binding protein
HQ398_08700	COG0765	amino acid transport
HQ398_08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_08710	COG4597	amino acid ABC transporter
HQ398_08715	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HQ398_08725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HQ398_08740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_08745	COG1360	Flagellar Motor Protein
HQ398_08750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_08755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_08760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_08760	COG0649	NAD binding
HQ398_08775	COG1034	ATP synthesis coupled electron transport
HQ398_08780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ398_08785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_08790	COG0839	Belongs to the complex I subunit 6 family
HQ398_08795	COG0713	ATP synthesis coupled electron transport
HQ398_08805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_08810	COG1007	ATP synthesis coupled electron transport
HQ398_08815	COG0047	phosphoribosylformylglycinamidine synthase activity
HQ398_08815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQ398_08820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ398_08825	COG1645	bacterial-type flagellum-dependent swarming motility
HQ398_08830	COG1160	GTP binding
HQ398_08835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_08840	COG2976	Protein conserved in bacteria
HQ398_08845	COG0124	histidyl-tRNA synthetase
HQ398_08865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQ398_08870	COG0105	UTP biosynthetic process
HQ398_08875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_08885	COG0633	Ferredoxin
HQ398_08890	COG0443	Heat shock 70 kDa protein
HQ398_08895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ398_08905	COG0822	iron-sulfur transferase activity
HQ398_08910	COG1104	cysteine desulfurase activity
HQ398_08915	COG1959	2 iron, 2 sulfur cluster binding
HQ398_08930	COG3154	lipid carrier protein
HQ398_08935	COG0826	peptidase U32
HQ398_08940	COG0826	peptidase U32
HQ398_08955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_08960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_08965	COG1862	Preprotein translocase
HQ398_08970	COG0343	queuine tRNA-ribosyltransferase activity
HQ398_08975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQ398_08980	COG0517	IMP dehydrogenase activity
HQ398_08980	COG1125	glycine betaine transport
HQ398_08990	COG3634	alkyl hydroperoxide reductase activity
HQ398_09035	COG1242	4 iron, 4 sulfur cluster binding
HQ398_09045	COG0493	'glutamate synthase
HQ398_09050	COG1126	abc transporter atp-binding protein
HQ398_09055	COG0765	amino acid transport
HQ398_09060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_09075	COG0513	Belongs to the DEAD box helicase family
HQ398_09090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HQ398_09105	COG2119	membrane
HQ398_09155	COG0215	cysteine-tRNA ligase activity
HQ398_09160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ398_09170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_09180	COG2261	transglycosylase associated protein
HQ398_09185	COG0642	Histidine kinase
HQ398_09225	COG3501	Rhs element vgr protein
HQ398_09280	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_09280	COG1454	alcohol dehydrogenase
HQ398_09295	COG1882	Formate acetyltransferase
HQ398_09300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_09310	COG4869	propanediol catabolic process
HQ398_09355	COG0322	excinuclease ABC activity
HQ398_09360	COG2197	response regulator
HQ398_09365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ398_09370	COG2835	tetraacyldisaccharide 4'-kinase activity
HQ398_09375	COG1663	tetraacyldisaccharide 4'-kinase activity
HQ398_09400	COG1448	Aminotransferase
HQ398_09410	COG0583	DNA-binding transcription factor activity
HQ398_09415	COG3085	chromosome segregation
HQ398_09420	COG4574	serine-type endopeptidase inhibitor activity
HQ398_09425	COG0584	glycerophosphoryl diester phosphodiesterase
HQ398_09435	COG1349	DNA-binding transcription factor activity
HQ398_09440	COG2271	Major facilitator Superfamily
HQ398_09445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ398_09450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQ398_09455	COG0840	transmembrane signaling receptor activity
HQ398_09465	COG0583	DNA-binding transcription factor activity
HQ398_09490	COG0656	L-ascorbic acid biosynthetic process
HQ398_09495	COG2814	Major facilitator Superfamily
HQ398_09500	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ398_09515	COG3220	belongs to the UPF0276 family
HQ398_09535	COG1294	oxidase, subunit
HQ398_09545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ398_09575	COG2807	transmembrane transport
HQ398_09580	COG1187	pseudouridine synthase activity
HQ398_09585	COG0346	lactoylglutathione lyase activity
HQ398_09595	COG1403	HNH endonuclease
HQ398_09600	COG4657	Part of a membrane complex involved in electron transport
HQ398_09605	COG2878	Part of a membrane complex involved in electron transport
HQ398_09615	COG4658	electron transport chain
HQ398_09620	COG4659	FMN binding
HQ398_09625	COG4660	Part of a membrane complex involved in electron transport
HQ398_09630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQ398_09635	COG0346	lactoylglutathione lyase activity
HQ398_09650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HQ398_09670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQ398_09675	COG0505	Belongs to the CarA family
HQ398_09680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQ398_09690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQ398_09695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HQ398_09700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ398_09705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ398_09710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_09715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HQ398_09740	COG2020	methyltransferase activity
HQ398_09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ398_09750	COG0861	Integral membrane protein TerC family
HQ398_09780	COG2095	MarC family integral membrane protein
HQ398_09785	COG1454	alcohol dehydrogenase
HQ398_09785	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_09795	COG3385	transposase activity
HQ398_09800	COG2194	sulfuric ester hydrolase activity
HQ398_09805	COG0217	transcriptional regulatory protein
HQ398_09810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQ398_09820	COG1801	Protein of unknown function DUF72
HQ398_09825	COG4106	trans-aconitate 2-methyltransferase activity
HQ398_09830	COG0500	methyltransferase
HQ398_09850	COG0450	alkyl hydroperoxide reductase
HQ398_09855	COG0583	DNA-binding transcription factor activity
HQ398_09860	COG0791	NLP P60 protein
HQ398_09870	COG0583	DNA-binding transcription factor activity
HQ398_09875	COG2610	gluconate transmembrane transporter activity
HQ398_09880	COG3048	D-serine ammonia-lyase activity
HQ398_09885	COG0538	isocitrate dehydrogenase activity
HQ398_09890	COG2207	Transcriptional regulator
HQ398_09915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_09930	COG4521	taurine ABC transporter
HQ398_09935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HQ398_09945	COG2175	clavaminate synthase activity
HQ398_09950	COG3152	Membrane
HQ398_09955	COG2814	Major facilitator Superfamily
HQ398_09960	COG0109	protoheme IX farnesyltransferase activity
HQ398_09965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HQ398_09970	COG1845	cytochrome c oxidase, subunit III
HQ398_09980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQ398_10015	COG1309	transcriptional regulator
HQ398_10025	COG1454	alcohol dehydrogenase
HQ398_10045	COG0534	Mate efflux family protein
HQ398_10060	COG2841	Protein conserved in bacteria
HQ398_10065	COG3132	Protein of unknown function, DUF480
HQ398_10095	COG0708	Exodeoxyribonuclease III
HQ398_10115	COG1122	ATPase activity
HQ398_10120	COG1122	ATPase activity
HQ398_10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_10145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ398_10155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ398_10160	COG1120	ATPase activity
HQ398_10165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_10170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_10175	COG2375	cellular response to nickel ion
HQ398_10180	COG3437	response regulator, receiver
HQ398_10180	COG0784	Response regulator, receiver
HQ398_10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ398_10195	COG0328	RNA-DNA hybrid ribonuclease activity
HQ398_10200	COG2226	methyltransferase
HQ398_10205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ398_10210	COG0741	lytic transglycosylase activity
HQ398_10210	COG1388	LysM domain
HQ398_10240	COG1376	ErfK ybiS ycfS ynhG family protein
HQ398_10240	COG1388	LysM domain
HQ398_10250	COG0471	metal ion transport
HQ398_10260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HQ398_10265	COG0791	NLP P60 protein
HQ398_10275	COG3118	belongs to the thioredoxin family
HQ398_10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ398_10290	COG0788	formyltetrahydrofolate deformylase activity
HQ398_10315	COG0739	heme binding
HQ398_10315	COG0741	lytic transglycosylase activity
HQ398_10315	COG1196	nuclear chromosome segregation
HQ398_10320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ398_10330	COG0436	Aminotransferase
HQ398_10335	COG1288	antiporter activity
HQ398_10340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ398_10345	COG1879	ABC-type sugar transport system periplasmic component
HQ398_10355	COG0406	alpha-ribazole phosphatase activity
HQ398_10360	COG2964	Protein conserved in bacteria
HQ398_10365	COG3681	Belongs to the UPF0597 family
HQ398_10375	COG0814	amino acid
HQ398_10395	COG1166	arginine decarboxylase activity
HQ398_10400	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_10430	COG0583	DNA-binding transcription factor activity
HQ398_10445	COG0840	transmembrane signaling receptor activity
HQ398_10450	COG0302	gtp cyclohydrolase
HQ398_10455	COG0303	'Molybdopterin
HQ398_10460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ398_10480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HQ398_10495	COG0314	molybdopterin synthase activity
HQ398_10500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HQ398_10505	COG0315	cyclic pyranopterin monophosphate synthase activity
HQ398_10515	COG3005	denitrification pathway
HQ398_10525	COG0348	domain, Protein
HQ398_10530	COG0437	4 iron, 4 sulfur cluster binding
HQ398_10535	COG0243	molybdopterin cofactor binding
HQ398_10545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_10545	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_10550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQ398_10555	COG3850	Histidine kinase
HQ398_10560	COG2197	response regulator
HQ398_10590	COG0121	glutamine amidotransferase
HQ398_10595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ398_10600	COG1960	acyl-CoA dehydrogenase activity
HQ398_10605	COG1473	amidohydrolase
HQ398_10610	COG2914	Belongs to the UPF0125 (RnfH) family
HQ398_10615	COG2867	negative regulation of translational initiation
HQ398_10620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQ398_10630	COG0582	viral genome integration into host DNA
HQ398_10645	COG3311	Transcriptional regulator
HQ398_10655	COG5377	YqaJ viral recombinase family
HQ398_10700	COG2003	Belongs to the UPF0758 family
HQ398_10720	COG3385	transposase activity
HQ398_10780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_10820	COG1715	Restriction endonuclease
HQ398_10830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HQ398_10885	COG2814	Major facilitator Superfamily
HQ398_10885	COG0477	Major facilitator Superfamily
HQ398_10890	COG0457	Tetratricopeptide repeat
HQ398_10895	COG1940	carbohydrate kinase activity
HQ398_10900	COG3383	formate dehydrogenase (NAD+) activity
HQ398_10910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HQ398_10920	COG1960	acyl-CoA dehydrogenase activity
HQ398_10925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQ398_10940	COG1317	bacterial-type flagellum organization
HQ398_10995	COG3385	transposase activity
HQ398_11035	COG0457	Tetratricopeptide repeat
HQ398_11105	COG4790	Type iii secretion
HQ398_11110	COG4794	Type iii secretion
HQ398_11115	COG4791	protein targeting
HQ398_11120	COG4792	protein secretion
HQ398_11135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_11140	COG1263	PTS System
HQ398_11140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_11145	COG1609	Transcriptional regulator
HQ398_11155	COG4821	SIS domain
HQ398_11165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_11165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_11165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_11175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_11185	COG1187	pseudouridine synthase activity
HQ398_11190	COG1051	belongs to the nudix hydrolase family
HQ398_11195	COG0482	sulfurtransferase activity
HQ398_11200	COG2915	High frequency lysogenization protein hflD homolog
HQ398_11205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HQ398_11210	COG2850	peptidyl-arginine hydroxylation
HQ398_11230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_11250	COG0625	glutathione transferase activity
HQ398_11255	COG0259	pyridoxamine-phosphate oxidase activity
HQ398_11260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_11260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_11270	COG1882	Formate acetyltransferase
HQ398_11275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ398_11290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HQ398_11305	COG3088	subunit of a heme lyase
HQ398_11305	COG4235	cytochrome complex assembly
HQ398_11315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ398_11320	COG1138	Cytochrome C-type biogenesis protein
HQ398_11325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HQ398_11330	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_11335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_11340	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_11355	COG0835	chemotaxis
HQ398_11365	COG1192	Involved in chromosome partitioning
HQ398_11370	COG1360	Flagellar Motor Protein
HQ398_11375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_11380	COG2201	protein-glutamate methylesterase activity
HQ398_11385	COG2198	Histidine kinase
HQ398_11385	COG0643	Histidine kinase
HQ398_11385	COG0784	Response regulator, receiver
HQ398_11390	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HQ398_11415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HQ398_11480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ398_11490	COG1677	Flagellar hook-basal body complex protein FliE
HQ398_11500	COG0469	pyruvate kinase activity
HQ398_11505	COG1737	Transcriptional regulator
HQ398_11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_11545	COG2233	PERMEase
HQ398_11550	COG0281	malic enzyme
HQ398_11555	COG0745	RESPONSE REGULATOR receiver
HQ398_11565	COG0437	4 iron, 4 sulfur cluster binding
HQ398_11570	COG3383	formate dehydrogenase (NAD+) activity
HQ398_11570	COG3383	formate dehydrogenase (NAD+) activity
HQ398_11610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ398_11620	COG3852	Histidine kinase
HQ398_11625	COG2204	response regulator
HQ398_11635	COG4662	Binding-protein-dependent transport system inner membrane component
HQ398_11640	COG1136	(ABC) transporter
HQ398_11650	COG0303	'Molybdopterin
HQ398_11655	COG1289	transmembrane transporter activity
HQ398_11660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_11700	COG0784	Response regulator, receiver
HQ398_11700	COG2205	protein histidine kinase activity
HQ398_11705	COG4166	transmembrane transport
HQ398_11710	COG0601	transmembrane transport
HQ398_11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ398_11720	COG0444	Belongs to the ABC transporter superfamily
HQ398_11725	COG4608	Belongs to the ABC transporter superfamily
HQ398_11760	COG3724	N-succinylarginine dihydrolase activity
HQ398_11785	COG5002	protein histidine kinase activity
HQ398_11785	COG0784	Response regulator, receiver
HQ398_11785	COG2205	protein histidine kinase activity
HQ398_11790	COG2197	response regulator
HQ398_11815	COG2200	EAL domain
HQ398_11815	COG2203	Gaf domain
HQ398_11815	COG2199	diguanylate cyclase activity
HQ398_11820	COG0826	peptidase U32
HQ398_11825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_11835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ398_11840	COG2203	Gaf domain
HQ398_11840	COG2199	diguanylate cyclase activity
HQ398_11845	COG2211	Major facilitator Superfamily
HQ398_11850	COG0616	signal peptide processing
HQ398_11855	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_11860	COG0583	DNA-binding transcription factor activity
HQ398_11870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_11885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQ398_11890	COG1881	PFAM PEBP family protein
HQ398_11910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQ398_11925	COG1301	dicarboxylic acid transport
HQ398_11930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQ398_11935	COG2912	Transglutaminase-like superfamily
HQ398_11945	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ398_11950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ398_11955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQ398_11960	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HQ398_11965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQ398_11975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ398_11980	COG0737	Belongs to the 5'-nucleotidase family
HQ398_11985	COG0193	aminoacyl-tRNA hydrolase activity
HQ398_11990	COG0012	GTP binding
HQ398_11995	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_12000	COG1177	transmembrane transport
HQ398_12005	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_12010	COG3842	ATPase activity
HQ398_12015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HQ398_12020	COG0583	DNA-binding transcription factor activity
HQ398_12065	COG0471	metal ion transport
HQ398_12065	COG0490	domain, Protein
HQ398_12085	COG3097	Belongs to the UPF0267 family
HQ398_12095	COG0366	Alpha amylase catalytic
HQ398_12100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_12100	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ398_12100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ398_12100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ398_12110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_12125	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_12140	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ398_12150	COG0180	Tryptophanyl-tRNA synthetase
HQ398_12160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQ398_12165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HQ398_12175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ398_12180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQ398_12210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ398_12215	COG0583	DNA-binding transcription factor activity
HQ398_12245	COG0739	heme binding
HQ398_12255	COG1511	domain protein
HQ398_12255	COG3264	Mechanosensitive ion channel
HQ398_12260	COG0584	glycerophosphoryl diester phosphodiesterase
HQ398_12270	COG1053	succinate dehydrogenase
HQ398_12275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HQ398_12280	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HQ398_12290	COG3366	ferrous iron transmembrane transporter activity
HQ398_12295	COG0700	Nucleoside recognition
HQ398_12300	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_12310	COG3214	Protein conserved in bacteria
HQ398_12325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_12340	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_12350	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_12375	COG0516	GMP reductase activity
HQ398_12385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQ398_12395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_12405	COG0583	DNA-binding transcription factor activity
HQ398_12420	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_12445	COG3706	GGDEF domain
HQ398_12450	COG1335	isochorismatase
HQ398_12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_12465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ398_12470	COG1702	phosphate starvation-inducible protein PhoH
HQ398_12475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQ398_12480	COG4535	Mg2 and Co2 transporter CorC
HQ398_12490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_12510	COG1970	mechanosensitive ion channel activity
HQ398_12515	COG4974	Belongs to the 'phage' integrase family
HQ398_12520	COG0716	FMN binding
HQ398_12530	COG0312	modulator of DNA gyrase
HQ398_12540	COG2888	peptidyl-tyrosine sulfation
HQ398_12545	COG0495	leucyl-tRNA aminoacylation
HQ398_12560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQ398_12565	COG0799	negative regulation of ribosome biogenesis
HQ398_12575	COG0768	penicillin binding
HQ398_12580	COG0772	Belongs to the SEDS family
HQ398_12585	COG2951	lytic endotransglycosylase activity
HQ398_12595	COG1686	Belongs to the peptidase S11 family
HQ398_12600	COG2921	Belongs to the UPF0250 family
HQ398_12605	COG0321	lipoyl(octanoyl) transferase activity
HQ398_12610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQ398_12630	COG3139	Protein of unknown function (DUF1315)
HQ398_12635	COG0252	asparaginase activity
HQ398_12640	COG0786	glutamate:sodium symporter activity
HQ398_12655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQ398_12665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ398_12670	COG0175	sulfate reduction
HQ398_12685	COG2966	Psort location CytoplasmicMembrane, score
HQ398_12695	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ398_12710	COG2897	thiosulfate sulfurtransferase activity
HQ398_12715	COG2066	Belongs to the glutaminase family
HQ398_12720	COG3171	Protein conserved in bacteria
HQ398_12725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQ398_12730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ398_12735	COG2200	EAL domain
HQ398_12750	COG4181	ATPase activity
HQ398_12755	COG2755	lipolytic protein G-D-S-L family
HQ398_12760	COG0784	Response regulator, receiver
HQ398_12760	COG0835	chemotaxis
HQ398_12800	COG3397	chitin binding
HQ398_12825	COG3655	Transcriptional regulator
HQ398_12835	COG2814	Major facilitator Superfamily
HQ398_12840	COG3385	transposase activity
HQ398_12875	COG2771	luxR family
HQ398_12900	COG0748	coenzyme F420 binding
HQ398_12905	COG3721	Heme iron utilization protein
HQ398_12915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_12930	COG3275	phosphorelay sensor kinase activity
HQ398_12935	COG3279	Response regulator of the LytR AlgR family
HQ398_12940	COG1966	Carbon starvation protein
HQ398_12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ398_12970	COG0737	Belongs to the 5'-nucleotidase family
HQ398_12995	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ398_13010	COG1047	Peptidyl-prolyl cis-trans
HQ398_13015	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HQ398_13025	COG0784	Response regulator, receiver
HQ398_13025	COG0835	chemotaxis
HQ398_13035	COG4251	negative regulation of phosphorylation
HQ398_13035	COG5001	Diguanylate cyclase
HQ398_13035	COG3706	GGDEF domain
HQ398_13035	COG2203	Gaf domain
HQ398_13040	COG3089	Belongs to the UPF0270 family
HQ398_13045	COG3954	Phosphoribulokinase
HQ398_13060	COG1765	OsmC-like protein
HQ398_13110	COG2313	pseudouridylate synthase activity
HQ398_13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ398_13160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_13170	COG2986	histidine ammonia-lyase
HQ398_13195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ398_13200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_13205	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_13230	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HQ398_13300	COG2985	domain, Protein
HQ398_13300	COG0569	domain protein
HQ398_13310	COG0076	glutamate decarboxylase activity
HQ398_13315	COG2917	probably involved in intracellular septation
HQ398_13320	COG2350	Protein conserved in bacteria
HQ398_13330	COG1349	DNA-binding transcription factor activity
HQ398_13340	COG2222	sugar isomerase
HQ398_13345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_13355	COG3716	PTS system mannose fructose sorbose family IID component
HQ398_13360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_13365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_13375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_13375	COG1263	PTS System
HQ398_13380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_13385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQ398_13390	COG1381	Involved in DNA repair and RecF pathway recombination
HQ398_13405	COG0681	Belongs to the peptidase S26 family
HQ398_13410	COG0481	GTPase activity
HQ398_13420	COG3026	antisigma factor binding
HQ398_13425	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HQ398_13430	COG1595	DNA-templated transcription, initiation
HQ398_13435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQ398_13450	COG0354	folic acid binding
HQ398_13495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_13505	COG0126	phosphoglycerate kinase activity
HQ398_13510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ398_13515	COG1940	carbohydrate kinase activity
HQ398_13520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQ398_13525	COG2816	NAD+ diphosphatase activity
HQ398_13535	COG4991	sh3 domain protein
HQ398_13540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_13550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HQ398_13585	COG2816	NAD+ diphosphatase activity
HQ398_13625	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HQ398_13635	COG2203	Gaf domain
HQ398_13635	COG2199	diguanylate cyclase activity
HQ398_13640	COG0513	Belongs to the DEAD box helicase family
HQ398_13645	COG0471	metal ion transport
HQ398_13655	COG3385	transposase activity
HQ398_13665	COG0154	amidase activity
HQ398_13670	COG2957	Belongs to the agmatine deiminase family
HQ398_13685	COG1902	pentaerythritol trinitrate reductase activity
HQ398_13695	COG4942	peptidase
HQ398_13695	COG1388	LysM domain
HQ398_13700	COG1238	metal cluster binding
HQ398_13705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQ398_13710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQ398_13715	COG0585	pseudouridine synthase activity
HQ398_13730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HQ398_13735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ398_13745	COG1376	ErfK ybiS ycfS ynhG family protein
HQ398_13750	COG0668	transmembrane transport
HQ398_13760	COG2731	YhcH YjgK YiaL family protein
HQ398_13770	COG1794	racemase activity, acting on amino acids and derivatives
HQ398_13800	COG0517	IMP dehydrogenase activity
HQ398_13800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ398_13805	COG0488	(ABC) transporter
HQ398_13815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HQ398_13825	COG3385	transposase activity
HQ398_13830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ398_13840	COG0148	phosphopyruvate hydratase activity
HQ398_13845	COG0504	CTP synthase activity
HQ398_13850	COG3956	TIGRFAM MazG family protein
HQ398_13855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ398_13870	COG4807	Protein conserved in bacteria
HQ398_13875	COG3023	N-Acetylmuramoyl-L-alanine amidase
HQ398_13880	COG0783	Belongs to the Dps family
HQ398_13885	COG1151	hydroxylamine reductase activity
HQ398_13890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_13895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ398_13900	COG0671	phosphoesterase, PA-phosphatase related
HQ398_13905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ398_13910	COG0163	prenyltransferase activity
HQ398_13925	COG1131	(ABC) transporter
HQ398_13930	COG0842	Transport permease protein
HQ398_13935	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HQ398_13940	COG1924	4 iron, 4 sulfur cluster binding
HQ398_13960	COG1823	symporter activity
HQ398_13970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQ398_13975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQ398_13980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HQ398_13990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_13995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ398_14000	COG1489	DNA binding
HQ398_14010	COG1643	Atp-dependent helicase
HQ398_14015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ398_14020	COG0346	lactoylglutathione lyase activity
HQ398_14025	COG2076	Multidrug Resistance protein
HQ398_14030	COG2076	Multidrug Resistance protein
HQ398_14040	COG3437	response regulator, receiver
HQ398_14040	COG0784	Response regulator, receiver
HQ398_14045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQ398_14060	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HQ398_14075	COG1136	(ABC) transporter
HQ398_14095	COG0840	transmembrane signaling receptor activity
HQ398_14110	COG0529	Catalyzes the synthesis of activated sulfate
HQ398_14115	COG2895	sulfate adenylyltransferase (ATP) activity
HQ398_14120	COG0175	sulfate reduction
HQ398_14125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_14125	COG1648	precorrin-2 dehydrogenase activity
HQ398_14130	COG0330	HflC and HflK could
HQ398_14135	COG1585	Membrane protein implicated in regulation of membrane protease activity
HQ398_14140	COG0840	transmembrane signaling receptor activity
HQ398_14145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQ398_14155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ398_14160	COG1640	4-alpha-glucanotransferase
HQ398_14165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ398_14185	COG1051	belongs to the nudix hydrolase family
HQ398_14210	COG0561	phosphatase activity
HQ398_14225	COG0733	neurotransmitter:sodium symporter activity
HQ398_14235	COG0733	neurotransmitter:sodium symporter activity
HQ398_14300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HQ398_14305	COG2885	chlorophyll binding
HQ398_14310	COG0823	Involved in the tonB-independent uptake of proteins
HQ398_14325	COG0811	peptide transport
HQ398_14330	COG0824	Thioesterase
HQ398_14335	COG3790	cyd operon protein YbgE
HQ398_14340	COG4890	Cyd operon protein YbgT
HQ398_14345	COG1294	oxidase, subunit
HQ398_14350	COG1271	oxidase subunit
HQ398_14355	COG2255	four-way junction helicase activity
HQ398_14360	COG0632	four-way junction helicase activity
HQ398_14365	COG0840	transmembrane signaling receptor activity
HQ398_14375	COG2771	luxR family
HQ398_14390	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HQ398_14395	COG4251	negative regulation of phosphorylation
HQ398_14395	COG2203	Gaf domain
HQ398_14395	COG3706	GGDEF domain
HQ398_14395	COG5001	Diguanylate cyclase
HQ398_14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_14415	COG2995	paraquat-inducible protein a
HQ398_14420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ398_14420	COG3008	intermembrane lipid transfer
HQ398_14425	COG3009	Protein conserved in bacteria
HQ398_14430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ398_14435	COG0442	prolyl-tRNA aminoacylation
HQ398_14460	COG4221	oxidoreductase activity
HQ398_14475	COG1024	Enoyl-CoA hydratase
HQ398_14485	COG0110	maltose O-acetyltransferase activity
HQ398_14495	COG4166	transmembrane transport
HQ398_14505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ398_14510	COG0735	belongs to the Fur family
HQ398_14540	COG0513	Belongs to the DEAD box helicase family
HQ398_14545	COG2153	protein acetylation
HQ398_14560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ398_14565	COG0557	exoribonuclease II activity
HQ398_14570	COG3706	GGDEF domain
HQ398_14580	COG3240	lipase activity
HQ398_14595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HQ398_14600	COG1194	a g-specific adenine glycosylase
HQ398_14605	COG0617	tRNA 3'-terminal CCA addition
HQ398_14625	COG3068	Protein conserved in bacteria
HQ398_14635	COG0739	heme binding
HQ398_14655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HQ398_14660	COG1121	(ABC) transporter
HQ398_14665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HQ398_14670	COG0583	DNA-binding transcription factor activity
HQ398_14675	COG0697	spore germination
HQ398_14680	COG1573	uracil-dna glycosylase
HQ398_14695	COG2827	Endonuclease containing a URI domain
HQ398_14710	COG1842	Phage shock protein A
HQ398_14715	COG0204	Acyl-transferase
HQ398_14735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ398_14740	COG0583	DNA-binding transcription factor activity
HQ398_14745	COG2084	Dehydrogenase
HQ398_14775	COG3104	oligopeptide transport
HQ398_14785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ398_14800	COG0187	DNA topoisomerase II activity
HQ398_14805	COG1289	transmembrane transporter activity
HQ398_14810	COG1566	PFAM secretion protein HlyD family protein
HQ398_14820	COG1051	belongs to the nudix hydrolase family
HQ398_14825	COG3150	esterase
HQ398_14835	COG3151	Protein conserved in bacteria
HQ398_14840	COG0494	nUDIX hydrolase
HQ398_14845	COG1538	Outer membrane efflux protein
HQ398_14850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ398_14850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ398_14855	COG1560	Kdo2-lipid A biosynthetic process
HQ398_14860	COG2213	PTS system mannitol-specific
HQ398_14860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_14865	COG0246	Mannitol dehydrogenase
HQ398_14870	COG3722	fumarate hydratase activity
HQ398_14895	COG1671	Belongs to the UPF0178 family
HQ398_14910	COG1988	membrane-bound metal-dependent
HQ398_14915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_14920	COG0513	Belongs to the DEAD box helicase family
HQ398_14940	COG1575	Belongs to the MenA family. Type 1 subfamily
HQ398_14945	COG1169	isochorismate synthase
HQ398_14960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HQ398_14970	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_14975	COG3291	Pkd domain containing protein
HQ398_14980	COG2949	membrane
HQ398_14985	COG0784	Response regulator, receiver
HQ398_14985	COG0835	chemotaxis
HQ398_14995	COG1444	tRNA N-acetyltransferase activity
HQ398_15015	COG1803	Methylglyoxal synthase
HQ398_15020	COG1979	alcohol dehydrogenase
HQ398_15035	COG4221	oxidoreductase activity
HQ398_15055	COG1285	pathogenesis
HQ398_15075	COG1368	sulfuric ester hydrolase activity
HQ398_15080	COG1522	sequence-specific DNA binding
HQ398_15090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HQ398_15095	COG1418	mRNA catabolic process
HQ398_15100	COG1058	Belongs to the CinA family
HQ398_15100	COG1546	Belongs to the CinA family
HQ398_15110	COG0561	phosphatase activity
HQ398_15120	COG2926	Belongs to the UPF0265 family
HQ398_15150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ398_15155	COG0564	pseudouridine synthase activity
HQ398_15165	COG0110	maltose O-acetyltransferase activity
HQ398_15170	COG0366	Alpha amylase catalytic
HQ398_15175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_15175	COG1263	PTS System
HQ398_15195	COG0252	asparaginase activity
HQ398_15200	COG1253	flavin adenine dinucleotide binding
HQ398_15205	COG0586	Pfam SNARE associated Golgi protein
HQ398_15210	COG1686	Belongs to the peptidase S11 family
HQ398_15245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HQ398_15250	COG0527	aspartate kinase activity
HQ398_15255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQ398_15265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ398_15270	COG1546	Belongs to the CinA family
HQ398_15275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ398_15280	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ398_15290	COG1346	cytolysis
HQ398_15295	COG1380	Effector of murein hydrolase LrgA
HQ398_15315	COG0583	DNA-binding transcription factor activity
HQ398_15340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQ398_15350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HQ398_15355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ398_15365	COG0137	argininosuccinate synthase activity
HQ398_15370	COG0165	Argininosuccinate lyase
HQ398_15385	COG3314	Sporulation integral membrane protein YlbJ
HQ398_15410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQ398_15415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HQ398_15430	COG0477	Major facilitator Superfamily
HQ398_15435	COG0523	cobalamin synthesis protein
HQ398_15445	COG2200	EAL domain
HQ398_15450	COG1049	propionate catabolic process, 2-methylcitrate cycle
HQ398_15455	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ398_15460	COG0840	transmembrane signaling receptor activity
HQ398_15470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ398_15475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ398_15480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HQ398_15485	COG2186	Transcriptional regulator
HQ398_15510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_15515	COG1459	type II secretion system
HQ398_15530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HQ398_15535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HQ398_15540	COG0494	nUDIX hydrolase
HQ398_15545	COG0653	protein targeting
HQ398_15555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQ398_15560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQ398_15565	COG0849	cell division
HQ398_15575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ398_15580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQ398_15585	COG0772	Belongs to the SEDS family
HQ398_15590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQ398_15595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ398_15600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQ398_15605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ398_15610	COG0768	penicillin binding
HQ398_15615	COG3116	cell division
HQ398_15620	COG0275	rRNA processing
HQ398_15625	COG2001	Belongs to the MraZ family
HQ398_15635	COG0741	lytic transglycosylase activity
HQ398_15635	COG1388	LysM domain
HQ398_15650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_15655	COG1191	sigma factor activity
HQ398_15680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HQ398_15685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_15690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_15705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_15710	COG1256	bacterial-type flagellum assembly
HQ398_15710	COG4786	Flagellar basal body rod
HQ398_15720	COG1706	bacterial-type flagellum-dependent cell motility
HQ398_15725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ398_15730	COG4786	Flagellar basal body rod
HQ398_15755	COG1815	bacterial-type flagellum-dependent cell motility
HQ398_15765	COG2747	anti-sigma28 factor FlgM
HQ398_15790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ398_15800	COG1677	Flagellar hook-basal body complex protein FliE
HQ398_15850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQ398_15855	COG3107	peptidoglycan biosynthetic process
HQ398_15860	COG0792	nuclease activity
HQ398_15865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ398_15875	COG2969	positive regulation of protein catabolic process
HQ398_15880	COG0625	glutathione transferase activity
HQ398_15885	COG2857	Cytochrome c1
HQ398_15890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HQ398_15900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQ398_15905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQ398_15910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HQ398_15920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ398_15925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ398_15955	COG3964	amidohydrolase
HQ398_15970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_15970	COG3711	transcriptional antiterminator
HQ398_15975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_15980	COG1660	Displays ATPase and GTPase activities
HQ398_15985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_15995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQ398_16000	COG1137	ATPase activity
HQ398_16005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HQ398_16015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQ398_16020	COG0517	IMP dehydrogenase activity
HQ398_16020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ398_16025	COG1127	ABC transporter
HQ398_16030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ398_16035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ398_16040	COG2854	intermembrane phospholipid transfer
HQ398_16050	COG5007	Belongs to the BolA IbaG family
HQ398_16055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQ398_16060	COG0312	modulator of DNA gyrase
HQ398_16065	COG3028	Belongs to the UPF0307 family
HQ398_16070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HQ398_16080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_16085	COG1011	Hydrolase
HQ398_16100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQ398_16105	COG0019	diaminopimelate decarboxylase activity
HQ398_16115	COG1965	Belongs to the frataxin family
HQ398_16120	COG0400	carboxylic ester hydrolase activity
HQ398_16125	COG3072	Adenylate cyclase
HQ398_16130	COG0181	hydroxymethylbilane synthase activity
HQ398_16140	COG2959	enzyme of heme biosynthesis
HQ398_16155	COG1494	fructose-1,6-bisphosphatase
HQ398_16180	COG1686	Belongs to the peptidase S11 family
HQ398_16210	COG2932	Transcriptional regulator
HQ398_16305	COG4695	Portal protein
HQ398_16445	COG0795	lipopolysaccharide-transporting ATPase activity
HQ398_16450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_16455	COG2927	DNA polymerase III (CHI subunit)
HQ398_16480	COG0456	acetyltransferase
HQ398_16480	COG0454	-acetyltransferase
HQ398_16505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ398_16510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HQ398_16515	COG5380	lipid catabolic process
HQ398_16540	COG2873	o-acetylhomoserine
HQ398_16570	COG3842	ATPase activity
HQ398_16580	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_16605	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_16620	COG2203	Gaf domain
HQ398_16620	COG2199	diguanylate cyclase activity
HQ398_16635	COG1074	ATP-dependent DNA helicase activity
HQ398_16645	COG2259	Doxx family
HQ398_16650	COG1741	Belongs to the pirin family
HQ398_16660	COG0583	DNA-binding transcription factor activity
HQ398_16685	COG4771	TonB-dependent receptor
HQ398_16725	COG0203	ribosomal protein L17
HQ398_16730	COG0202	RNA polymerase activity
HQ398_16735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQ398_16740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQ398_16745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQ398_16750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ398_16755	COG0201	protein transport
HQ398_16760	COG0200	Binds to the 23S rRNA
HQ398_16765	COG1841	ribosomal large subunit assembly
HQ398_16770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQ398_16775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQ398_16780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQ398_16785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQ398_16790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQ398_16795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQ398_16800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQ398_16805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQ398_16810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQ398_16815	COG0255	Belongs to the universal ribosomal protein uL29 family
HQ398_16820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQ398_16825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQ398_16830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQ398_16835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQ398_16840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQ398_16845	COG0089	rRNA binding
HQ398_16850	COG0088	Forms part of the polypeptide exit tunnel
HQ398_16855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQ398_16860	COG0051	transcription antitermination factor activity, RNA binding
HQ398_16880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ398_16885	COG2183	response to ionizing radiation
HQ398_16905	COG0596	Alpha beta hydrolase
HQ398_16910	COG1040	competence protein
HQ398_16915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ398_16915	COG0316	Belongs to the HesB IscA family
HQ398_16920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQ398_16925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HQ398_16930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_16935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ398_16940	COG4942	peptidase
HQ398_16965	COG0800	Aldolase
HQ398_16975	COG3265	gluconokinase activity
HQ398_16980	COG2610	gluconate transmembrane transporter activity
HQ398_16985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ398_16990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQ398_17000	COG0456	acetyltransferase
HQ398_17005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HQ398_17010	COG1490	D-aminoacyl-tRNA deacylase activity
HQ398_17025	COG3385	transposase activity
HQ398_17030	COG3385	transposase activity
HQ398_17040	COG1295	ribonuclease BN
HQ398_17050	COG0814	amino acid
HQ398_17055	COG0702	epimerase
HQ398_17065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQ398_17070	COG0254	rRNA binding
HQ398_17085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ398_17090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HQ398_17100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQ398_17110	COG0514	ATP-dependent DNA helicase (RecQ)
HQ398_17115	COG2050	protein possibly involved in aromatic compounds catabolism
HQ398_17130	COG2258	MOSC domain
HQ398_17135	COG1177	transmembrane transport
HQ398_17140	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_17145	COG3842	ATPase activity
HQ398_17165	COG0174	glutamine synthetase
HQ398_17185	COG3045	CreA protein
HQ398_17190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_17195	COG0443	Heat shock 70 kDa protein
HQ398_17210	COG0366	Alpha amylase catalytic
HQ398_17225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ398_17250	COG3250	beta-galactosidase activity
HQ398_17255	COG1609	Transcriptional regulator
HQ398_17260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ398_17265	COG1085	galactose-1-phosphate uridylyltransferase
HQ398_17270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HQ398_17275	COG2017	converts alpha-aldose to the beta-anomer
HQ398_17280	COG1968	undecaprenyl-diphosphatase activity
HQ398_17290	COG1595	DNA-templated transcription, initiation
HQ398_17310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HQ398_17315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HQ398_17325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_17335	COG0842	Transport permease protein
HQ398_17340	COG0842	Transport permease protein
HQ398_17345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ398_17355	COG2116	formate transmembrane transporter activity
HQ398_17360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_17360	COG1648	precorrin-2 dehydrogenase activity
HQ398_17365	COG3177	Filamentation induced by cAMP protein fic
HQ398_17375	COG2239	Acts as a magnesium transporter
HQ398_17380	COG1079	Belongs to the binding-protein-dependent transport system permease family
HQ398_17385	COG4603	Belongs to the binding-protein-dependent transport system permease family
HQ398_17390	COG3845	ABC transporter
HQ398_17395	COG1744	ABC transporter substrate-binding protein PnrA-like
HQ398_17400	COG0210	DNA helicase
HQ398_17455	COG1280	lysine exporter protein (LysE YggA)
HQ398_17480	COG3306	glycosyltransferase involved in LPS biosynthesis
HQ398_17500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_17510	COG0156	8-amino-7-oxononanoate synthase activity
HQ398_17515	COG1063	alcohol dehydrogenase
HQ398_17520	COG3245	cytochrome
HQ398_17535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQ398_17540	COG2166	iron-sulfur cluster assembly
HQ398_17545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HQ398_17590	COG0583	DNA-binding transcription factor activity
HQ398_17605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQ398_17610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQ398_17615	COG2223	nitrite transmembrane transporter activity
HQ398_17620	COG3279	Response regulator of the LytR AlgR family
HQ398_17625	COG3275	phosphorelay sensor kinase activity
HQ398_17630	COG2081	HI0933 family
HQ398_17635	COG1528	Iron-storage protein
HQ398_17640	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ398_17645	COG0589	response to stress
HQ398_17685	COG3642	lipopolysaccharide core region biosynthetic process
HQ398_17690	COG0859	PFAM glycosyl transferase family 9
HQ398_17700	COG1758	RNA polymerase activity
HQ398_17705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ398_17710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ398_17725	COG0561	phosphatase activity
HQ398_17760	COG1309	transcriptional regulator
HQ398_17765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_17770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ398_17775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_17775	COG4191	Histidine kinase
HQ398_17780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ398_17800	COG2205	protein histidine kinase activity
HQ398_17805	COG0745	RESPONSE REGULATOR receiver
HQ398_17810	COG2814	Major facilitator Superfamily
HQ398_17820	COG3977	Valine--pyruvate aminotransferase
HQ398_17825	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ398_17830	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ398_17835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ398_17845	COG2378	regulation of single-species biofilm formation
HQ398_17865	COG0592	DNA-directed DNA polymerase activity
HQ398_17870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQ398_17885	COG1126	abc transporter atp-binding protein
HQ398_17890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQ398_17895	COG0594	ribonuclease P activity
HQ398_17900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQ398_17905	COG0706	membrane insertase activity
HQ398_17910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQ398_17915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HQ398_17920	COG0445	tRNA wobble uridine modification
HQ398_17925	COG0357	Ribosomal RNA small subunit methyltransferase G
HQ398_17930	COG1192	Involved in chromosome partitioning
HQ398_17935	COG1475	DNA binding
HQ398_17945	COG0356	it plays a direct role in the translocation of protons across the membrane
HQ398_17955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQ398_17960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ398_17965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQ398_17970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQ398_17975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQ398_17980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQ398_17985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ398_17990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ398_18035	COG0297	glycogen (starch) synthase activity
HQ398_18035	COG0438	transferase activity, transferring glycosyl groups
HQ398_18050	COG4452	Inner membrane protein CreD
HQ398_18070	COG0745	RESPONSE REGULATOR receiver
HQ398_18075	COG1349	DNA-binding transcription factor activity
HQ398_18080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQ398_18085	COG2771	luxR family
HQ398_18095	COG0811	peptide transport
HQ398_18100	COG0811	peptide transport
HQ398_18105	COG0848	biopolymer transport protein
HQ398_18110	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ398_18145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HQ398_18150	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_18155	COG2226	methyltransferase
HQ398_18165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HQ398_18175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ398_18180	COG0805	protein transport
HQ398_18185	COG0084	hydrolase, TatD family'
HQ398_18195	COG3469	chitinase activity
HQ398_18210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_18215	COG0742	ribosomal rna small subunit methyltransferase
HQ398_18225	COG0248	Ppx GppA phosphatase
HQ398_18230	COG0513	Belongs to the DEAD box helicase family
HQ398_18235	COG3118	belongs to the thioredoxin family
HQ398_18250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HQ398_18265	COG2960	long-chain fatty acid transporting porin activity
HQ398_18275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_18320	COG3706	GGDEF domain
HQ398_18320	COG4251	negative regulation of phosphorylation
HQ398_18320	COG2203	Gaf domain
HQ398_18320	COG5001	Diguanylate cyclase
HQ398_18330	COG0751	glycine-tRNA ligase activity
HQ398_18335	COG0752	glycyl-tRNA synthetase alpha subunit
HQ398_18340	COG2818	Glycosylase
HQ398_18345	COG0840	transmembrane signaling receptor activity
HQ398_18350	COG2885	chlorophyll binding
HQ398_18355	COG0251	oxidation-reduction process
HQ398_18360	COG0425	Belongs to the sulfur carrier protein TusA family
HQ398_18385	COG0183	Belongs to the thiolase family
HQ398_18390	COG1024	Enoyl-CoA hydratase
HQ398_18390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ398_18395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ398_18400	COG0006	proline dipeptidase activity
HQ398_18405	COG1739	Uncharacterized protein family UPF0029
HQ398_18410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_18415	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HQ398_18465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQ398_18470	COG0166	Belongs to the GPI family
HQ398_18475	COG0668	transmembrane transport
HQ398_18480	COG1309	transcriptional regulator
HQ398_18485	COG0756	dUTP diphosphatase activity
HQ398_18490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HQ398_18495	COG2003	Belongs to the UPF0758 family
HQ398_18500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQ398_18505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQ398_18515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HQ398_18520	COG2990	Protein conserved in bacteria
HQ398_18525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQ398_18530	COG0859	PFAM glycosyl transferase family 9
HQ398_18535	COG0463	Glycosyl transferase, family 2
HQ398_18540	COG0859	PFAM glycosyl transferase family 9
HQ398_18545	COG1519	Transferase
HQ398_18560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_18565	COG1609	Transcriptional regulator
HQ398_18570	COG0604	alcohol dehydrogenase
HQ398_18585	COG1580	Controls the rotational direction of flagella during chemotaxis
HQ398_18590	COG3161	chorismate lyase activity
HQ398_18595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HQ398_18600	COG2937	Belongs to the GPAT DAPAT family
HQ398_18605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQ398_18620	COG0534	Mate efflux family protein
HQ398_18625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HQ398_18630	COG2205	protein histidine kinase activity
HQ398_18635	COG0745	RESPONSE REGULATOR receiver
HQ398_18645	COG1045	serine acetyltransferase
HQ398_18655	COG3074	FtsZ-dependent cytokinesis
HQ398_18660	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HQ398_18670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HQ398_18705	COG1609	Transcriptional regulator
HQ398_18710	COG3250	beta-galactosidase activity
HQ398_18715	COG2731	YhcH YjgK YiaL family protein
HQ398_18720	COG0531	amino acid
HQ398_18725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_18730	COG0531	amino acid
HQ398_18735	COG0385	Bile acid
HQ398_18775	COG0583	DNA-binding transcription factor activity
HQ398_18790	COG0583	DNA-binding transcription factor activity
HQ398_18795	COG1561	YicC-like family, N-terminal region
HQ398_18800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HQ398_18805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQ398_18820	COG5001	Diguanylate cyclase
HQ398_18820	COG4251	negative regulation of phosphorylation
HQ398_18820	COG3706	GGDEF domain
HQ398_18820	COG2203	Gaf domain
HQ398_18825	COG3084	Protein conserved in bacteria
HQ398_18835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HQ398_18840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ398_18850	COG1335	isochorismatase
HQ398_18860	COG1683	Conserved Protein
HQ398_18865	COG0204	Acyl-transferase
HQ398_18870	COG0204	Acyl-transferase
HQ398_18875	COG0606	chelatase, subunit chli
HQ398_18885	COG3978	acetolactate synthase activity
HQ398_18895	COG0129	dihydroxy-acid dehydratase activity
HQ398_18905	COG1401	restriction endodeoxyribonuclease activity
HQ398_18910	COG1401	restriction endodeoxyribonuclease activity
HQ398_18950	COG2391	methyltransferase activity
HQ398_18955	COG2962	Rard protein
HQ398_18965	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_18990	COG0583	DNA-binding transcription factor activity
HQ398_19015	COG1322	Protein conserved in bacteria
HQ398_19025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HQ398_19045	COG0174	glutamine synthetase
HQ398_19050	COG1217	gtp-binding protein TYPA
HQ398_19055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_19060	COG0569	domain protein
HQ398_19065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_19065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_19070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ398_19075	COG0242	peptide deformylase activity
HQ398_19080	COG1652	LysM domain
HQ398_19085	COG0758	DNA mediated transformation
HQ398_19090	COG2922	Belongs to the Smg family
HQ398_19095	COG0551	DNA topoisomerase type I activity
HQ398_19105	COG0009	L-threonylcarbamoyladenylate synthase
HQ398_19110	COG0408	coproporphyrinogen oxidase activity
HQ398_19115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQ398_19125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQ398_19135	COG3078	GTPase activator activity
HQ398_19175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ398_19180	COG1288	antiporter activity
HQ398_19185	COG1438	arginine binding
HQ398_19190	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HQ398_19195	COG0540	Belongs to the ATCase OTCase family
HQ398_19210	COG0688	phosphatidylethanolamine metabolic process
HQ398_19215	COG0583	DNA-binding transcription factor activity
HQ398_19235	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HQ398_19250	COG3040	lipid binding
HQ398_19255	COG2207	Transcriptional regulator
HQ398_19260	COG1979	alcohol dehydrogenase
HQ398_19265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HQ398_19270	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HQ398_19280	COG3681	Belongs to the UPF0597 family
HQ398_19290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_19295	COG2076	Multidrug Resistance protein
HQ398_19300	COG2076	Multidrug Resistance protein
HQ398_19305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HQ398_19310	COG0726	polysaccharide deacetylase
HQ398_19325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ398_19330	COG3385	transposase activity
HQ398_19350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_19355	COG0564	pseudouridine synthase activity
HQ398_19365	COG0542	response to heat
HQ398_19370	COG2502	aspartate--ammonia ligase
HQ398_19375	COG1522	sequence-specific DNA binding
HQ398_19385	COG5413	integral membrane protein
HQ398_19405	COG2205	protein histidine kinase activity
HQ398_19415	COG2204	response regulator
HQ398_19430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HQ398_19460	COG0243	molybdopterin cofactor binding
HQ398_19465	COG3005	denitrification pathway
HQ398_19470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_19470	COG4191	Histidine kinase
HQ398_19480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQ398_19485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_19490	COG0569	domain protein
HQ398_19495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQ398_19520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ398_19535	COG0250	Participates in transcription elongation, termination and antitermination
HQ398_19540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQ398_19545	COG0081	regulation of translation
HQ398_19550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQ398_19555	COG0222	ribosome binding
HQ398_19560	COG0085	RNA polymerase activity
HQ398_19565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQ398_19570	COG2964	Protein conserved in bacteria
HQ398_19580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ398_19585	COG2923	Belongs to the DsrF TusC family
HQ398_19590	COG2168	tRNA wobble position uridine thiolation
HQ398_19595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQ398_19600	COG0049	tRNA binding
HQ398_19605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQ398_19610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ398_19615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ398_19685	COG0583	DNA-binding transcription factor activity
HQ398_19695	COG1301	dicarboxylic acid transport
HQ398_19705	COG2095	MarC family integral membrane protein
HQ398_19715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ398_19735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ398_19750	COG1770	oligopeptidase
HQ398_19765	COG4221	oxidoreductase activity
HQ398_19770	COG0583	DNA-binding transcription factor activity
HQ398_19775	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ398_19800	COG0742	ribosomal rna small subunit methyltransferase
HQ398_19805	COG0552	protein localization to endoplasmic reticulum
HQ398_19810	COG2884	Cell division ATP-binding protein ftsE
HQ398_19815	COG2177	Part of the ABC transporter FtsEX involved in
HQ398_19825	COG0288	reversible hydration of carbon dioxide
HQ398_19830	COG2188	Transcriptional regulator
HQ398_19835	COG1228	amidohydrolase
HQ398_19840	COG0010	Belongs to the arginase family
HQ398_19845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQ398_19850	COG2986	histidine ammonia-lyase
HQ398_19855	COG0387	Pfam Sodium calcium exchanger
HQ398_19865	COG2200	EAL domain
HQ398_19870	COG2200	EAL domain
HQ398_19870	COG2199	diguanylate cyclase activity
HQ398_19915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_19920	COG1459	type II secretion system
HQ398_19935	COG2165	general secretion pathway protein
HQ398_19965	COG1077	Cell shape determining protein MreB Mrl
HQ398_19970	COG1792	Involved in formation and maintenance of cell shape
HQ398_19975	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HQ398_19980	COG0424	maF-like protein
HQ398_19985	COG1530	ribonuclease E activity
HQ398_19990	COG3164	Protein of unknown function
HQ398_20000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ398_20005	COG0312	modulator of DNA gyrase
HQ398_20020	COG0477	Major facilitator Superfamily
HQ398_20060	COG0646	methionine synthase
HQ398_20060	COG1410	methionine synthase
HQ398_20065	COG0189	ligase activity
HQ398_20070	COG0642	Histidine kinase
HQ398_20075	COG0745	RESPONSE REGULATOR receiver
HQ398_20090	COG0789	Transcriptional regulator
HQ398_20095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HQ398_20100	COG0352	thiamine-phosphate diphosphorylase activity
HQ398_20105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ398_20115	COG2022	thiamine diphosphate biosynthetic process
HQ398_20120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ398_20125	COG1943	Transposase
HQ398_20145	COG0110	maltose O-acetyltransferase activity
HQ398_20160	COG0814	amino acid
HQ398_20165	COG3932	Exopolysaccharide synthesis, ExoD
HQ398_20180	COG0004	ammonium transporteR
HQ398_20185	COG3133	Outer membrane lipoprotein
HQ398_20190	COG0456	acetyltransferase
HQ398_20215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ398_20220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HQ398_20235	COG0671	phosphoesterase, PA-phosphatase related
HQ398_20240	COG0628	permease
HQ398_20250	COG2957	Belongs to the agmatine deiminase family
HQ398_20255	COG3284	Transcriptional regulator
HQ398_20270	COG1461	Dihydroxyacetone kinase
HQ398_20275	COG2376	Dihydroxyacetone kinase
HQ398_20280	COG2252	PERMEase
HQ398_20300	COG0629	single-stranded DNA binding
HQ398_20305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQ398_20315	COG3047	cAMP biosynthetic process
HQ398_20320	COG0840	transmembrane signaling receptor activity
HQ398_20345	COG3135	benzoate transporter
HQ398_20350	COG1396	sequence-specific DNA binding
HQ398_20385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_20385	COG1042	CoA-binding domain protein
HQ398_20385	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ398_20410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ398_20415	COG0038	chloride channel
HQ398_20425	COG0316	Belongs to the HesB IscA family
HQ398_20430	COG1757	Na H antiporter
HQ398_20470	COG0297	glycogen (starch) synthase activity
HQ398_20475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ398_20485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ398_20490	COG3025	triphosphatase activity
HQ398_20495	COG1392	Phosphate transport regulator
HQ398_20500	COG0306	phosphate transporter
HQ398_20505	COG0527	aspartate kinase activity
HQ398_20505	COG0460	homoserine dehydrogenase
HQ398_20510	COG0626	cystathionine gamma-synthase activity
HQ398_20525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_20530	COG0814	amino acid
HQ398_20535	COG1218	3'(2'),5'-bisphosphate nucleotidase
HQ398_20540	COG0494	nUDIX hydrolase
HQ398_20545	COG1011	Hydrolase
HQ398_20560	COG0110	maltose O-acetyltransferase activity
HQ398_20570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HQ398_20580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HQ398_20585	COG4208	sulfate ABC transporter
HQ398_20590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HQ398_20595	COG0583	DNA-binding transcription factor activity
HQ398_20605	COG0765	amino acid transport
HQ398_20615	COG1126	abc transporter atp-binding protein
HQ398_20620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_20625	COG3397	chitin binding
HQ398_20630	COG0840	transmembrane signaling receptor activity
HQ398_20645	COG0726	polysaccharide deacetylase
HQ398_20645	COG1649	PFAM Uncharacterised BCR, COG1649
HQ398_20650	COG1215	transferase activity, transferring glycosyl groups
HQ398_20680	COG1328	CTP reductase activity
HQ398_20685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_20700	COG1448	Aminotransferase
HQ398_20705	COG2194	sulfuric ester hydrolase activity
HQ398_20725	COG1215	transferase activity, transferring glycosyl groups
HQ398_20730	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HQ398_20735	COG3118	belongs to the thioredoxin family
HQ398_20735	COG0457	Tetratricopeptide repeat
HQ398_20775	COG0513	Belongs to the DEAD box helicase family
HQ398_20805	COG3112	Uncharacterised protein family (UPF0231)
HQ398_20810	COG3835	regulator
HQ398_20815	COG2610	gluconate transmembrane transporter activity
HQ398_20820	COG1929	Belongs to the glycerate kinase type-1 family
HQ398_20835	COG0583	DNA-binding transcription factor activity
HQ398_20840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_20850	COG1872	DUF167
HQ398_20855	COG0762	integral membrane protein
HQ398_20860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HQ398_20865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQ398_20880	COG3022	response to hydroperoxide
HQ398_20900	COG0347	Belongs to the P(II) protein family
HQ398_20905	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ398_20915	COG3842	ATPase activity
HQ398_20920	COG2837	iron assimilation
HQ398_20925	COG1438	arginine binding
HQ398_20930	COG1126	abc transporter atp-binding protein
HQ398_20935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_20940	COG4215	(ABC) transporter
HQ398_20945	COG4160	amino acid transport
HQ398_20950	COG0039	L-malate dehydrogenase activity
HQ398_20965	COG1017	nitric oxide dioxygenase activity
HQ398_20965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_20975	COG4536	flavin adenine dinucleotide binding
HQ398_20980	COG4137	Cytochrome C assembly protein
HQ398_20985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQ398_20990	COG0228	four-way junction DNA binding
HQ398_20995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQ398_21000	COG0336	Belongs to the RNA methyltransferase TrmD family
HQ398_21005	COG0335	large ribosomal subunit rRNA binding
HQ398_21020	COG1051	belongs to the nudix hydrolase family
HQ398_21030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQ398_21035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ398_21040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ398_21050	COG0583	DNA-binding transcription factor activity
HQ398_21055	COG0640	Transcriptional regulator
HQ398_21060	COG0268	Binds directly to 16S ribosomal RNA
HQ398_21070	COG0196	riboflavin kinase activity
HQ398_21080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQ398_21085	COG1047	Peptidyl-prolyl cis-trans
HQ398_21090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQ398_21125	COG4969	Belongs to the N-Me-Phe pilin family
HQ398_21130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQ398_21130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ398_21145	COG1854	S-ribosylhomocysteine lyase activity
HQ398_21155	COG2165	general secretion pathway protein
HQ398_21160	COG0084	hydrolase, TatD family'
HQ398_21165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_21175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQ398_21180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HQ398_21185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HQ398_21190	COG0813	purine-nucleoside phosphorylase activity
HQ398_21215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HQ398_21225	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HQ398_21230	COG0776	regulation of translation
HQ398_21245	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ398_21250	COG0360	Binds together with S18 to 16S ribosomal RNA
HQ398_21255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQ398_21260	COG0359	binds to the 23S rRNA
HQ398_21265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_21285	COG0604	alcohol dehydrogenase
HQ398_21285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ398_21285	COG3321	synthase
HQ398_21285	COG4221	oxidoreductase activity
HQ398_21290	COG1238	metal cluster binding
HQ398_21295	COG0612	Peptidase, M16
HQ398_21300	COG2918	glutathione biosynthetic process
HQ398_21305	COG1022	Amp-dependent synthetase and ligase
HQ398_21310	COG0456	acetyltransferase
HQ398_21325	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HQ398_21340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ398_21350	COG0477	Major facilitator Superfamily
HQ398_21355	COG0583	DNA-binding transcription factor activity
HQ398_21365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_21370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_21380	COG0673	inositol 2-dehydrogenase activity
HQ398_21390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQ398_21395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ398_21400	COG3036	rescue of stalled ribosome
HQ398_21415	COG0138	bifunctional purine biosynthesis protein purh
HQ398_21420	COG0151	Belongs to the GarS family
HQ398_21440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ398_21445	COG0358	DNA primase activity
HQ398_21450	COG1610	YqeY-like protein
HQ398_21455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQ398_21460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQ398_21465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ398_21470	COG1027	Aspartate ammonia-lyase
HQ398_21475	COG3030	protein affecting phage T7 exclusion by the F plasmid
HQ398_21480	COG0534	Mate efflux family protein
HQ398_21485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQ398_21490	COG0459	protein refolding
HQ398_21540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HQ398_21545	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HQ398_21550	COG1178	ABC-type Fe3 transport system permease component
HQ398_21555	COG4143	(ABC) transporter
HQ398_21570	COG0066	3-isopropylmalate dehydratase activity