locus-tag	class	description
HQ400_00005	COG1272	protein, Hemolysin III
HQ400_00010	COG0569	domain protein
HQ400_00010	COG2985	domain, Protein
HQ400_00055	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HQ400_00075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ400_00080	COG1028	Short-chain dehydrogenase reductase Sdr
HQ400_00090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ400_00125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ400_00140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ400_00175	COG2313	pseudouridylate synthase activity
HQ400_00180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ400_00195	COG3385	transposase activity
HQ400_00230	COG1765	OsmC-like protein
HQ400_00245	COG3954	Phosphoribulokinase
HQ400_00250	COG3089	Belongs to the UPF0270 family
HQ400_00255	COG4251	negative regulation of phosphorylation
HQ400_00255	COG5001	Diguanylate cyclase
HQ400_00255	COG2203	Gaf domain
HQ400_00255	COG3706	GGDEF domain
HQ400_00260	COG0429	hydrolase of the alpha beta-hydrolase fold
HQ400_00265	COG0784	Response regulator, receiver
HQ400_00265	COG0835	chemotaxis
HQ400_00275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HQ400_00280	COG1047	Peptidyl-prolyl cis-trans
HQ400_00295	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ400_00300	COG2204	response regulator
HQ400_00320	COG0737	Belongs to the 5'-nucleotidase family
HQ400_00335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ400_00355	COG3279	Response regulator of the LytR AlgR family
HQ400_00375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ400_00385	COG3721	Heme iron utilization protein
HQ400_00390	COG0748	coenzyme F420 binding
HQ400_00415	COG2814	Major facilitator Superfamily
HQ400_00425	COG3655	Transcriptional regulator
HQ400_00450	COG3397	chitin binding
HQ400_00490	COG0835	chemotaxis
HQ400_00490	COG0784	Response regulator, receiver
HQ400_00495	COG2755	lipolytic protein G-D-S-L family
HQ400_00500	COG4181	ATPase activity
HQ400_00505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HQ400_00510	COG1090	epimerase
HQ400_00515	COG2200	EAL domain
HQ400_00520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ400_00525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQ400_00530	COG3171	Protein conserved in bacteria
HQ400_00535	COG2066	Belongs to the glutaminase family
HQ400_00540	COG2897	thiosulfate sulfurtransferase activity
HQ400_00555	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ400_00560	COG3385	transposase activity
HQ400_00570	COG2966	Psort location CytoplasmicMembrane, score
HQ400_00575	COG3610	response to peptide
HQ400_00585	COG0175	sulfate reduction
HQ400_00590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ400_00600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQ400_00615	COG0786	glutamate:sodium symporter activity
HQ400_00620	COG0252	asparaginase activity
HQ400_00625	COG3139	Protein of unknown function (DUF1315)
HQ400_00650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQ400_00655	COG0321	lipoyl(octanoyl) transferase activity
HQ400_00660	COG2921	Belongs to the UPF0250 family
HQ400_00665	COG1686	Belongs to the peptidase S11 family
HQ400_00670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQ400_00675	COG2951	lytic endotransglycosylase activity
HQ400_00680	COG0772	Belongs to the SEDS family
HQ400_00685	COG0768	penicillin binding
HQ400_00690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HQ400_00695	COG0799	negative regulation of ribosome biogenesis
HQ400_00700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQ400_00720	COG2888	peptidyl-tyrosine sulfation
HQ400_00730	COG0312	modulator of DNA gyrase
HQ400_00740	COG0716	FMN binding
HQ400_00745	COG4974	Belongs to the 'phage' integrase family
HQ400_00750	COG1970	mechanosensitive ion channel activity
HQ400_00765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HQ400_00770	COG4535	Mg2 and Co2 transporter CorC
HQ400_00775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQ400_00780	COG1702	phosphate starvation-inducible protein PhoH
HQ400_00785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ400_00790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ400_00795	COG1335	isochorismatase
HQ400_00800	COG1278	Cold shock
HQ400_00830	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ400_00840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HQ400_00845	COG0583	DNA-binding transcription factor activity
HQ400_00865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQ400_00875	COG0516	GMP reductase activity
HQ400_00900	COG1028	Short-chain dehydrogenase reductase Sdr
HQ400_00910	COG0318	PFAM AMP-dependent synthetase and ligase
HQ400_00925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ400_00950	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ400_00955	COG0700	Nucleoside recognition
HQ400_00960	COG3366	ferrous iron transmembrane transporter activity
HQ400_00970	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HQ400_00975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HQ400_00980	COG1053	succinate dehydrogenase
HQ400_01005	COG0739	heme binding
HQ400_01015	COG0583	DNA-binding transcription factor activity
HQ400_01040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ400_01070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQ400_01075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ400_01085	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HQ400_01090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQ400_01100	COG0180	Tryptophanyl-tRNA synthetase
HQ400_01110	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ400_01115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQ400_01125	COG1012	belongs to the aldehyde dehydrogenase family
HQ400_01140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ400_01155	COG0366	Alpha amylase catalytic
HQ400_01175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HQ400_01185	COG0471	metal ion transport
HQ400_01185	COG0490	domain, Protein
HQ400_01230	COG0583	DNA-binding transcription factor activity
HQ400_01245	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ400_01250	COG1177	transmembrane transport
HQ400_01290	COG3385	transposase activity
HQ400_01300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ400_01335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HQ400_01355	COG4735	regulation of single-species biofilm formation
HQ400_01370	COG2003	Belongs to the UPF0758 family
HQ400_01415	COG5377	YqaJ viral recombinase family
HQ400_01425	COG0012	GTP binding
HQ400_01430	COG0193	aminoacyl-tRNA hydrolase activity
HQ400_01435	COG0737	Belongs to the 5'-nucleotidase family
HQ400_01440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ400_01450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQ400_01455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HQ400_01460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQ400_01465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ400_01470	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ400_01480	COG2912	Transglutaminase-like superfamily
HQ400_01485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQ400_01490	COG1301	dicarboxylic acid transport
HQ400_01505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQ400_01515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HQ400_01515	COG3408	Glycogen debranching enzyme
HQ400_01525	COG1881	PFAM PEBP family protein
HQ400_01530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQ400_01545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ400_01560	COG1028	Short-chain dehydrogenase reductase Sdr
HQ400_01565	COG0616	signal peptide processing
HQ400_01570	COG2211	Major facilitator Superfamily
HQ400_01575	COG2199	diguanylate cyclase activity
HQ400_01575	COG2203	Gaf domain
HQ400_01580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ400_01590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ400_01595	COG0826	peptidase U32
HQ400_01600	COG2199	diguanylate cyclase activity
HQ400_01600	COG2200	EAL domain
HQ400_01600	COG2203	Gaf domain
HQ400_01630	COG2197	response regulator
HQ400_01635	COG2205	protein histidine kinase activity
HQ400_01635	COG5002	protein histidine kinase activity
HQ400_01635	COG0784	Response regulator, receiver
HQ400_01695	COG4608	Belongs to the ABC transporter superfamily
HQ400_01700	COG0444	Belongs to the ABC transporter superfamily
HQ400_01715	COG4166	transmembrane transport
HQ400_01720	COG2205	protein histidine kinase activity
HQ400_01720	COG0784	Response regulator, receiver
HQ400_01760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ400_01770	COG0303	'Molybdopterin
HQ400_01785	COG4662	Binding-protein-dependent transport system inner membrane component
HQ400_01795	COG2204	response regulator
HQ400_01800	COG3852	Histidine kinase
HQ400_01810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ400_01850	COG3383	formate dehydrogenase (NAD+) activity
HQ400_01850	COG3383	formate dehydrogenase (NAD+) activity
HQ400_01855	COG0437	4 iron, 4 sulfur cluster binding
HQ400_01865	COG0745	RESPONSE REGULATOR receiver
HQ400_01885	COG2233	PERMEase
HQ400_01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_01925	COG1737	Transcriptional regulator
HQ400_01930	COG0469	pyruvate kinase activity
HQ400_01940	COG1677	Flagellar hook-basal body complex protein FliE
HQ400_01950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ400_02005	COG1684	flagellar biosynthetic protein fliR
HQ400_02015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HQ400_02040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HQ400_02045	COG0643	Histidine kinase
HQ400_02045	COG0784	Response regulator, receiver
HQ400_02045	COG2198	Histidine kinase
HQ400_02050	COG2201	protein-glutamate methylesterase activity
HQ400_02055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ400_02060	COG1360	Flagellar Motor Protein
HQ400_02065	COG1192	Involved in chromosome partitioning
HQ400_02075	COG0835	chemotaxis
HQ400_02095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ400_02100	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ400_02105	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HQ400_02115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ400_02125	COG3088	subunit of a heme lyase
HQ400_02125	COG4235	cytochrome complex assembly
HQ400_02140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HQ400_02155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ400_02160	COG1882	Formate acetyltransferase
HQ400_02170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ400_02170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ400_02200	COG0259	pyridoxamine-phosphate oxidase activity
HQ400_02205	COG0625	glutathione transferase activity
HQ400_02225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ400_02245	COG2850	peptidyl-arginine hydroxylation
HQ400_02250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HQ400_02255	COG2915	High frequency lysogenization protein hflD homolog
HQ400_02260	COG0482	sulfurtransferase activity
HQ400_02265	COG1051	belongs to the nudix hydrolase family
HQ400_02280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_02290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_02290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_02290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_02320	COG1609	Transcriptional regulator
HQ400_02330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ400_02345	COG4792	protein secretion
HQ400_02355	COG4794	Type iii secretion
HQ400_02435	COG0457	Tetratricopeptide repeat
HQ400_02465	COG3385	transposase activity
HQ400_02475	COG3385	transposase activity
HQ400_02530	COG1317	bacterial-type flagellum organization
HQ400_02545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQ400_02550	COG1960	acyl-CoA dehydrogenase activity
HQ400_02560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HQ400_02570	COG3383	formate dehydrogenase (NAD+) activity
HQ400_02575	COG1940	carbohydrate kinase activity
HQ400_02585	COG2814	Major facilitator Superfamily
HQ400_02585	COG0477	Major facilitator Superfamily
HQ400_02600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQ400_02605	COG2867	negative regulation of translational initiation
HQ400_02610	COG2914	Belongs to the UPF0125 (RnfH) family
HQ400_02615	COG1473	amidohydrolase
HQ400_02620	COG1960	acyl-CoA dehydrogenase activity
HQ400_02625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ400_02630	COG0121	glutamine amidotransferase
HQ400_02660	COG2197	response regulator
HQ400_02665	COG3850	Histidine kinase
HQ400_02670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQ400_02675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ400_02675	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ400_02690	COG0437	4 iron, 4 sulfur cluster binding
HQ400_02705	COG3005	denitrification pathway
HQ400_02710	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ400_02720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HQ400_02725	COG0314	molybdopterin synthase activity
HQ400_02760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ400_02770	COG0302	gtp cyclohydrolase
HQ400_02775	COG0840	transmembrane signaling receptor activity
HQ400_02795	COG3385	transposase activity
HQ400_02835	COG3385	transposase activity
HQ400_02845	COG3385	transposase activity
HQ400_02850	COG2129	metallophosphoesterase
HQ400_02855	COG3385	transposase activity
HQ400_02860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HQ400_02900	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ400_02905	COG1166	arginine decarboxylase activity
HQ400_02925	COG0814	amino acid
HQ400_02940	COG2964	Protein conserved in bacteria
HQ400_02945	COG0406	alpha-ribazole phosphatase activity
HQ400_02960	COG1879	ABC-type sugar transport system periplasmic component
HQ400_02970	COG1288	antiporter activity
HQ400_02975	COG0436	Aminotransferase
HQ400_02985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ400_03015	COG0788	formyltetrahydrofolate deformylase activity
HQ400_03020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ400_03030	COG3118	belongs to the thioredoxin family
HQ400_03040	COG0791	NLP P60 protein
HQ400_03045	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HQ400_03055	COG0471	metal ion transport
HQ400_03065	COG1376	ErfK ybiS ycfS ynhG family protein
HQ400_03065	COG1388	LysM domain
HQ400_03110	COG0328	RNA-DNA hybrid ribonuclease activity
HQ400_03115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ400_03130	COG0784	Response regulator, receiver
HQ400_03130	COG3437	response regulator, receiver
HQ400_03140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ400_03145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ400_03150	COG1120	ATPase activity
HQ400_03155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ400_03190	COG0708	Exodeoxyribonuclease III
HQ400_03220	COG3132	Protein of unknown function, DUF480
HQ400_03225	COG2841	Protein conserved in bacteria
HQ400_03255	COG1454	alcohol dehydrogenase
HQ400_03265	COG1309	transcriptional regulator
HQ400_03300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQ400_03305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HQ400_03310	COG1845	cytochrome c oxidase, subunit III
HQ400_03315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HQ400_03320	COG0109	protoheme IX farnesyltransferase activity
HQ400_03325	COG2814	Major facilitator Superfamily
HQ400_03330	COG3152	Membrane
HQ400_03345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_03360	COG1482	cell wall glycoprotein biosynthetic process
HQ400_03370	COG0538	isocitrate dehydrogenase activity
HQ400_03375	COG3048	D-serine ammonia-lyase activity
HQ400_03380	COG2610	gluconate transmembrane transporter activity
HQ400_03385	COG0583	DNA-binding transcription factor activity
HQ400_03395	COG0791	NLP P60 protein
HQ400_03400	COG0583	DNA-binding transcription factor activity
HQ400_03405	COG0450	alkyl hydroperoxide reductase
HQ400_03425	COG0500	methyltransferase
HQ400_03430	COG4106	trans-aconitate 2-methyltransferase activity
HQ400_03435	COG1801	Protein of unknown function DUF72
HQ400_03445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQ400_03450	COG0217	transcriptional regulatory protein
HQ400_03460	COG2095	MarC family integral membrane protein
HQ400_03470	COG0601	transmembrane transport
HQ400_03475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ400_03490	COG0861	Integral membrane protein TerC family
HQ400_03495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ400_03500	COG2020	methyltransferase activity
HQ400_03520	COG4139	cobalamin transport
HQ400_03530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ400_03535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ400_03540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ400_03545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HQ400_03550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQ400_03560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQ400_03565	COG0505	Belongs to the CarA family
HQ400_03570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQ400_03605	COG0346	lactoylglutathione lyase activity
HQ400_03610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQ400_03620	COG4659	FMN binding
HQ400_03625	COG4658	electron transport chain
HQ400_03635	COG2878	Part of a membrane complex involved in electron transport
HQ400_03640	COG4657	Part of a membrane complex involved in electron transport
HQ400_03655	COG3385	transposase activity
HQ400_03670	COG3385	transposase activity
HQ400_03675	COG0346	lactoylglutathione lyase activity
HQ400_03680	COG1187	pseudouridine synthase activity
HQ400_03685	COG2807	transmembrane transport
HQ400_03710	COG2979	Protein of unknown function (DUF533)
HQ400_03715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ400_03745	COG3220	belongs to the UPF0276 family
HQ400_03760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ400_03770	COG0656	L-ascorbic acid biosynthetic process
HQ400_03785	COG0693	protein deglycase activity
HQ400_03790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ400_03815	COG0583	DNA-binding transcription factor activity
HQ400_03830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQ400_03835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ400_03840	COG2271	Major facilitator Superfamily
HQ400_03845	COG1349	DNA-binding transcription factor activity
HQ400_03855	COG0584	glycerophosphoryl diester phosphodiesterase
HQ400_03860	COG4574	serine-type endopeptidase inhibitor activity
HQ400_03865	COG3085	chromosome segregation
HQ400_03870	COG0583	DNA-binding transcription factor activity
HQ400_03880	COG1448	Aminotransferase
HQ400_03895	COG2333	competence protein COMEC
HQ400_03895	COG0658	competence protein
HQ400_03905	COG1663	tetraacyldisaccharide 4'-kinase activity
HQ400_03910	COG2835	tetraacyldisaccharide 4'-kinase activity
HQ400_03915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ400_03920	COG2197	response regulator
HQ400_03925	COG0322	excinuclease ABC activity
HQ400_03955	COG0582	viral genome integration into host DNA
HQ400_03975	COG3385	transposase activity
HQ400_03995	COG3385	transposase activity
HQ400_04050	COG0642	Histidine kinase
HQ400_04055	COG2261	transglycosylase associated protein
HQ400_04065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ400_04075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ400_04080	COG0215	cysteine-tRNA ligase activity
HQ400_04090	COG0419	ATPase involved in DNA repair
HQ400_04105	COG3385	transposase activity
HQ400_04140	COG2119	membrane
HQ400_04145	COG0023	Translation Initiation Factor
HQ400_04155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HQ400_04170	COG0513	Belongs to the DEAD box helicase family
HQ400_04185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_04190	COG0765	amino acid transport
HQ400_04195	COG1126	abc transporter atp-binding protein
HQ400_04200	COG0493	'glutamate synthase
HQ400_04210	COG1242	4 iron, 4 sulfur cluster binding
HQ400_04255	COG3634	alkyl hydroperoxide reductase activity
HQ400_04270	COG0517	IMP dehydrogenase activity
HQ400_04270	COG1125	glycine betaine transport
HQ400_04275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQ400_04280	COG0343	queuine tRNA-ribosyltransferase activity
HQ400_04285	COG1862	Preprotein translocase
HQ400_04290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ400_04295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ400_04310	COG0826	peptidase U32
HQ400_04315	COG0826	peptidase U32
HQ400_04320	COG3154	lipid carrier protein
HQ400_04335	COG1959	2 iron, 2 sulfur cluster binding
HQ400_04340	COG1104	cysteine desulfurase activity
HQ400_04345	COG0822	iron-sulfur transferase activity
HQ400_04355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ400_04360	COG0443	Heat shock 70 kDa protein
HQ400_04365	COG0633	Ferredoxin
HQ400_04375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ400_04380	COG0105	UTP biosynthetic process
HQ400_04385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQ400_04405	COG0124	histidyl-tRNA synthetase
HQ400_04410	COG2976	Protein conserved in bacteria
HQ400_04415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ400_04420	COG1160	GTP binding
HQ400_04425	COG1645	bacterial-type flagellum-dependent swarming motility
HQ400_04430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ400_04435	COG0047	phosphoribosylformylglycinamidine synthase activity
HQ400_04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQ400_04440	COG1007	ATP synthesis coupled electron transport
HQ400_04445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ400_04455	COG0713	ATP synthesis coupled electron transport
HQ400_04460	COG0839	Belongs to the complex I subunit 6 family
HQ400_04465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ400_04470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ400_04475	COG1034	ATP synthesis coupled electron transport
HQ400_04490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ400_04490	COG0649	NAD binding
HQ400_04495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ400_04500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ400_04505	COG1360	Flagellar Motor Protein
HQ400_04510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ400_04525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HQ400_04535	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HQ400_04550	COG0765	amino acid transport
HQ400_04555	COG1126	abc transporter atp-binding protein
HQ400_04565	COG0724	RNA recognition motif
HQ400_04570	COG4989	oxidoreductase activity
HQ400_04595	COG3437	response regulator, receiver
HQ400_04600	COG0583	DNA-binding transcription factor activity
HQ400_04605	COG3300	MHYT domain
HQ400_04605	COG5001	Diguanylate cyclase
HQ400_04610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HQ400_04630	COG2814	Major facilitator Superfamily
HQ400_04640	COG0583	DNA-binding transcription factor activity
HQ400_04645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ400_04650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQ400_04655	COG0539	negative regulation of cytoplasmic translation
HQ400_04660	COG0776	regulation of translation
HQ400_04670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HQ400_04690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HQ400_04695	COG0602	queuosine metabolic process
HQ400_04700	COG3530	Putative quorum-sensing-regulated virulence factor
HQ400_04705	COG2096	Adenosyltransferase
HQ400_04710	COG2916	Histone family protein nucleoid-structuring protein H-NS
HQ400_04715	COG1757	Na H antiporter
HQ400_04720	COG1435	thymidine kinase activity
HQ400_04750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ400_04770	COG2205	protein histidine kinase activity
HQ400_04775	COG0745	RESPONSE REGULATOR receiver
HQ400_04800	COG1278	Cold shock
HQ400_04805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HQ400_04810	COG0542	response to heat
HQ400_04815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQ400_04820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HQ400_04825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQ400_04830	COG3134	Outer membrane lipoprotein
HQ400_04835	COG3706	GGDEF domain
HQ400_04840	COG0492	ferredoxin-NADP+ reductase activity
HQ400_04845	COG0686	Belongs to the AlaDH PNT family
HQ400_04855	COG1674	ftsk spoiiie
HQ400_04855	COG0531	amino acid
HQ400_04860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HQ400_04865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HQ400_04870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQ400_04875	COG1286	toxin biosynthetic process
HQ400_04880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HQ400_04890	COG0563	adenylate kinase activity
HQ400_04895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ400_04905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ400_04920	COG5001	Diguanylate cyclase
HQ400_04920	COG3300	MHYT domain
HQ400_04975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HQ400_04980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ400_04995	COG0513	Belongs to the DEAD box helicase family
HQ400_05010	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQ400_05015	COG0383	alpha-mannosidase activity
HQ400_05020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_05020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ400_05020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_05025	COG2188	Transcriptional regulator
HQ400_05030	COG1570	exodeoxyribonuclease VII activity
HQ400_05040	COG3385	transposase activity
HQ400_05060	COG0517	IMP dehydrogenase activity
HQ400_05060	COG0516	GMP reductase activity
HQ400_05065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ400_05065	COG0519	Catalyzes the synthesis of GMP from XMP
HQ400_05085	COG3385	transposase activity
HQ400_05105	COG2062	phosphohistidine phosphatase, SixA
HQ400_05115	COG0697	spore germination
HQ400_05125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQ400_05140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ400_05145	COG1136	(ABC) transporter
HQ400_05150	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ400_05155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HQ400_05165	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQ400_05170	COG0740	serine-type endopeptidase activity
HQ400_05175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQ400_05185	COG0776	regulation of translation
HQ400_05190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ400_05200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ400_05205	COG3162	membrane
HQ400_05220	COG1024	Enoyl-CoA hydratase
HQ400_05235	COG3228	Belongs to the MtfA family
HQ400_05240	COG1584	GPR1 FUN34 yaaH family protein
HQ400_05270	COG1024	Enoyl-CoA hydratase
HQ400_05275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQ400_05290	COG1024	Enoyl-CoA hydratase
HQ400_05295	COG1024	Enoyl-CoA hydratase
HQ400_05315	COG0730	response to heat
HQ400_05335	COG3385	transposase activity
HQ400_05355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ400_05360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ400_05380	COG0295	cytidine deaminase activity
HQ400_05385	COG1346	cytolysis
HQ400_05390	COG1380	Effector of murein hydrolase LrgA
HQ400_05395	COG3345	alpha-galactosidase
HQ400_05405	COG2925	Exonuclease
HQ400_05415	COG3706	GGDEF domain
HQ400_05420	COG2840	Smr protein MutS2
HQ400_05425	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ400_05440	COG0513	Belongs to the DEAD box helicase family
HQ400_05445	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HQ400_05455	COG2719	SpoVR family
HQ400_05460	COG2718	Belongs to the UPF0229 family
HQ400_05470	COG0514	ATP-dependent DNA helicase (RecQ)
HQ400_05475	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HQ400_05480	COG0814	amino acid
HQ400_05500	COG1760	l-serine dehydratase
HQ400_05510	COG3123	guanosine phosphorylase activity
HQ400_05520	COG0205	6-phosphofructokinase activity
HQ400_05530	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HQ400_05535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ400_05545	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HQ400_05565	COG0242	peptide deformylase activity
HQ400_05585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ400_05590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ400_05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ400_05605	COG0549	Belongs to the carbamate kinase family
HQ400_05610	COG0697	spore germination
HQ400_05615	COG3608	succinylglutamate desuccinylase aspartoacylase
HQ400_05615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQ400_05620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ400_05625	COG2068	MobA-Related Protein
HQ400_05635	COG0493	'glutamate synthase
HQ400_05635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ400_05640	COG0402	S-adenosylhomocysteine deaminase activity
HQ400_05660	COG0402	S-adenosylhomocysteine deaminase activity
HQ400_05665	COG2252	PERMEase
HQ400_05670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ400_05675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ400_05680	COG2080	2 iron, 2 sulfur cluster binding
HQ400_05685	COG3134	Outer membrane lipoprotein
HQ400_05700	COG2199	diguanylate cyclase activity
HQ400_05735	COG0107	imidazoleglycerol-phosphate synthase activity
HQ400_05740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQ400_05745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQ400_05755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ400_05760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ400_05765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQ400_05775	COG1199	ATP-dependent helicase activity
HQ400_05780	COG1214	PFAM Peptidase M22, glycoprotease
HQ400_05790	COG0596	Alpha beta hydrolase
HQ400_05795	COG0318	PFAM AMP-dependent synthetase and ligase
HQ400_05805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ400_05810	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HQ400_05815	COG0709	Synthesizes selenophosphate from selenide and ATP
HQ400_05825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ400_05830	COG0840	transmembrane signaling receptor activity
HQ400_05835	COG1254	Belongs to the acylphosphatase family
HQ400_05845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ400_05845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ400_05850	COG0489	protein tyrosine kinase activity
HQ400_05855	COG0572	uridine kinase
HQ400_05860	COG0717	Belongs to the dCTP deaminase family
HQ400_05865	COG0306	phosphate transporter
HQ400_05875	COG1530	ribonuclease E activity
HQ400_05890	COG0424	maF-like protein
HQ400_05895	COG1399	metal-binding, possibly nucleic acid-binding protein
HQ400_05900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQ400_05905	COG0416	fatty acid biosynthetic process
HQ400_05910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ400_05920	COG1028	Short-chain dehydrogenase reductase Sdr
HQ400_05925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ400_05935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQ400_05940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQ400_05945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HQ400_05950	COG0470	DNA polymerase III
HQ400_05955	COG0084	hydrolase, TatD family'
HQ400_05975	COG3008	intermembrane lipid transfer
HQ400_05980	COG2995	paraquat-inducible protein a
HQ400_05990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HQ400_05995	COG0372	Belongs to the citrate synthase family
HQ400_06020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ400_06035	COG3385	transposase activity
HQ400_06040	COG4221	oxidoreductase activity
HQ400_06050	COG3141	response to X-ray
HQ400_06070	COG1067	ATP-dependent peptidase activity
HQ400_06085	COG0488	(ABC) transporter
HQ400_06095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ400_06095	COG0116	Belongs to the methyltransferase superfamily
HQ400_06115	COG0840	transmembrane signaling receptor activity
HQ400_06120	COG0835	chemotaxis
HQ400_06130	COG2201	protein-glutamate methylesterase activity
HQ400_06135	COG5001	Diguanylate cyclase
HQ400_06135	COG4251	negative regulation of phosphorylation
HQ400_06135	COG3706	GGDEF domain
HQ400_06135	COG2203	Gaf domain
HQ400_06155	COG0167	dihydroorotate dehydrogenase activity
HQ400_06170	COG0308	aminopeptidase N
HQ400_06180	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HQ400_06185	COG1956	GAF domain-containing protein
HQ400_06195	COG3278	Belongs to the heme-copper respiratory oxidase family
HQ400_06210	COG2010	Cytochrome c
HQ400_06235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ400_06240	COG0589	response to stress
HQ400_06245	COG0037	tRNA processing
HQ400_06270	COG1177	transmembrane transport
HQ400_06280	COG0625	glutathione transferase activity
HQ400_06285	COG1869	D-ribose catabolic process
HQ400_06290	COG1129	ABC transporter
HQ400_06305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ400_06310	COG1609	Transcriptional regulator
HQ400_06335	COG0776	regulation of translation
HQ400_06340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ400_06340	COG0072	phenylalanine-tRNA ligase activity
HQ400_06345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQ400_06355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQ400_06360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQ400_06365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQ400_06370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQ400_06390	COG0366	Alpha amylase catalytic
HQ400_06400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ400_06410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ400_06420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ400_06425	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HQ400_06430	COG3313	Fe-S protein
HQ400_06440	COG1105	Belongs to the carbohydrate kinase PfkB family
HQ400_06445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_06445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_06450	COG1609	Transcriptional regulator
HQ400_06455	COG0814	amino acid
HQ400_06465	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ400_06465	COG1024	Enoyl-CoA hydratase
HQ400_06470	COG0183	Belongs to the thiolase family
HQ400_06475	COG0714	Associated with various cellular activities
HQ400_06505	COG1595	DNA-templated transcription, initiation
HQ400_06515	COG2067	long-chain fatty acid transport protein
HQ400_06520	COG2067	long-chain fatty acid transport protein
HQ400_06525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HQ400_06555	COG0617	tRNA 3'-terminal CCA addition
HQ400_06555	COG0517	IMP dehydrogenase activity
HQ400_06555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQ400_06560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ400_06575	COG3385	transposase activity
HQ400_06580	COG3385	transposase activity
HQ400_06615	COG3385	transposase activity
HQ400_06625	COG3385	transposase activity
HQ400_06635	COG2824	Alkylphosphonate utilization operon protein PhnA
HQ400_06640	COG3100	YcgL domain-containing protein
HQ400_06645	COG0850	regulation of cytokinetic process
HQ400_06650	COG2894	cell division
HQ400_06655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HQ400_06660	COG3099	Belongs to the UPF0263 family
HQ400_06665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ400_06705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ400_06710	COG0697	spore germination
HQ400_06720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ400_06735	COG0307	riboflavin synthase, alpha
HQ400_06805	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ400_06810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ400_06840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ400_06845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ400_06845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HQ400_06860	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ400_06890	COG0417	DNA replication proofreading
HQ400_06915	COG1560	Kdo2-lipid A biosynthetic process
HQ400_06930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HQ400_06945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQ400_06955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQ400_06960	COG2832	Protein of unknown function (DUF454)
HQ400_06965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ400_06975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HQ400_07065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ400_07115	COG3593	DNA synthesis involved in DNA repair
HQ400_07130	COG0583	DNA-binding transcription factor activity
HQ400_07135	COG0730	response to heat
HQ400_07140	COG3148	PFAM DTW domain containing protein
HQ400_07145	COG1846	Transcriptional regulator
HQ400_07145	COG1940	carbohydrate kinase activity
HQ400_07150	COG0840	transmembrane signaling receptor activity
HQ400_07165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQ400_07170	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HQ400_07175	COG0247	lactate metabolic process
HQ400_07190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ400_07195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HQ400_07200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HQ400_07210	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ400_07215	COG3842	ATPase activity
HQ400_07225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ400_07255	COG3385	transposase activity
HQ400_07265	COG3385	transposase activity
HQ400_07275	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ400_07280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ400_07285	COG0567	Dehydrogenase, E1 component
HQ400_07295	COG1053	succinate dehydrogenase
HQ400_07300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HQ400_07305	COG2009	succinate dehydrogenase
HQ400_07355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ400_07370	COG2501	S4 domain
HQ400_07380	COG1132	(ABC) transporter
HQ400_07385	COG1132	(ABC) transporter
HQ400_07390	COG3437	response regulator, receiver
HQ400_07390	COG3850	Histidine kinase
HQ400_07390	COG4999	Histidine kinase
HQ400_07390	COG2205	protein histidine kinase activity
HQ400_07395	COG3118	belongs to the thioredoxin family
HQ400_07400	COG0471	metal ion transport
HQ400_07405	COG0058	SHG alpha-glucan phosphorylase activity
HQ400_07420	COG2983	Belongs to the UPF0260 family
HQ400_07425	COG1882	Formate acetyltransferase
HQ400_07430	COG2116	formate transmembrane transporter activity
HQ400_07435	COG1944	ATP diphosphatase activity
HQ400_07445	COG0583	DNA-binding transcription factor activity
HQ400_07460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HQ400_07465	COG0583	DNA-binding transcription factor activity
HQ400_07470	COG0583	DNA-binding transcription factor activity
HQ400_07475	COG2910	NAD(P)H-binding
HQ400_07490	COG1022	Amp-dependent synthetase and ligase
HQ400_07505	COG0861	Integral membrane protein TerC family
HQ400_07510	COG2885	chlorophyll binding
HQ400_07530	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQ400_07540	COG3768	UPF0283 membrane protein
HQ400_07560	COG1842	Phage shock protein A
HQ400_07565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HQ400_07590	COG4172	Belongs to the ABC transporter superfamily
HQ400_07595	COG0326	Molecular chaperone. Has ATPase activity
HQ400_07600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQ400_07640	COG0672	)-iron permease
HQ400_07660	COG2814	Major facilitator Superfamily
HQ400_07675	COG0840	transmembrane signaling receptor activity
HQ400_07680	COG0596	Alpha beta hydrolase
HQ400_07860	COG3646	Phage regulatory protein
HQ400_07920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ400_07930	COG0527	aspartate kinase activity
HQ400_07945	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ400_07950	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ400_07980	COG0393	Putative heavy-metal-binding
HQ400_07985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HQ400_07990	COG0285	dihydrofolate synthase activity
HQ400_07995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQ400_08000	COG0101	tRNA pseudouridine synthase activity
HQ400_08010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ400_08015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ400_08020	COG0671	phosphoesterase, PA-phosphatase related
HQ400_08025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ400_08030	COG2056	Na+-H+ antiporter family
HQ400_08035	COG5001	Diguanylate cyclase
HQ400_08035	COG3300	MHYT domain
HQ400_08050	COG2050	protein possibly involved in aromatic compounds catabolism
HQ400_08060	COG0247	lactate metabolic process
HQ400_08060	COG0277	FAD linked oxidase domain protein
HQ400_08070	COG1253	flavin adenine dinucleotide binding
HQ400_08075	COG1902	pentaerythritol trinitrate reductase activity
HQ400_08090	COG0647	UMP catabolic process
HQ400_08120	COG0625	glutathione transferase activity
HQ400_08130	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HQ400_08145	COG0564	pseudouridine synthase activity
HQ400_08150	COG4160	amino acid transport
HQ400_08170	COG2431	L-lysine efflux transmembrane transporter activity
HQ400_08175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ400_08190	COG1393	Belongs to the ArsC family
HQ400_08200	COG4783	chaperone-mediated protein folding
HQ400_08205	COG0425	Belongs to the sulfur carrier protein TusA family
HQ400_08230	COG3842	ATPase activity
HQ400_08235	COG3833	ABC-type maltose transport systems, permease component
HQ400_08240	COG1175	transmembrane transport
HQ400_08255	COG3082	Protein of unknown function (DUF1414)
HQ400_08265	COG1464	Belongs to the NlpA lipoprotein family
HQ400_08320	COG0509	glycine decarboxylation via glycine cleavage system
HQ400_08325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQ400_08330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ400_08335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ400_08355	COG0243	molybdopterin cofactor binding
HQ400_08360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ400_08365	COG0583	DNA-binding transcription factor activity
HQ400_08375	COG0625	glutathione transferase activity
HQ400_08385	COG0483	inositol monophosphate 1-phosphatase activity
HQ400_08400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ400_08410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ400_08415	COG1086	Polysaccharide biosynthesis protein
HQ400_08430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ400_08435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ400_08445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HQ400_08460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQ400_08510	COG0301	tRNA thio-modification
HQ400_08510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ400_08530	COG2373	Large extracellular alpha-helical protein
HQ400_08550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ400_08560	COG1252	NADH dehydrogenase
HQ400_08565	COG3150	esterase
HQ400_08570	COG2233	PERMEase
HQ400_08575	COG1164	Oligoendopeptidase f
HQ400_08580	COG2354	Protein conserved in bacteria
HQ400_08590	COG1301	dicarboxylic acid transport
HQ400_08605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ400_08620	COG0537	adenosine 5'-monophosphoramidase activity
HQ400_08655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ400_08660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ400_08670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ400_08700	COG0123	including yeast histone deacetylase and acetoin utilization protein
HQ400_08705	COG0477	Major facilitator Superfamily
HQ400_08735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ400_08740	COG2197	response regulator
HQ400_08760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_08765	COG0765	amino acid transport
HQ400_08785	COG0531	amino acid
HQ400_08800	COG1253	flavin adenine dinucleotide binding
HQ400_08805	COG0704	Plays a role in the regulation of phosphate uptake
HQ400_08810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQ400_08815	COG0581	inorganic phosphate transmembrane transporter activity
HQ400_08820	COG0573	inorganic phosphate transmembrane transporter activity
HQ400_08825	COG0590	tRNA wobble adenosine to inosine editing
HQ400_08845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQ400_08865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQ400_08870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQ400_08875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQ400_08880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQ400_08905	COG2716	regulation of RNA biosynthetic process
HQ400_08910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ400_08920	COG2239	Acts as a magnesium transporter
HQ400_08935	COG3951	Flagellar rod assembly protein muramidase FlgJ
HQ400_08935	COG1705	Flagellar rod assembly protein muramidase FlgJ
HQ400_08940	COG1706	bacterial-type flagellum-dependent cell motility
HQ400_08945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ400_08955	COG4787	bacterial-type flagellum-dependent cell motility
HQ400_08965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HQ400_08975	COG1815	bacterial-type flagellum-dependent cell motility
HQ400_08980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQ400_08985	COG0784	Response regulator, receiver
HQ400_08985	COG0835	chemotaxis
HQ400_08990	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HQ400_09005	COG0622	Phosphoesterase
HQ400_09010	COG4166	transmembrane transport
HQ400_09035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ400_09040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ400_09050	COG1349	DNA-binding transcription factor activity
HQ400_09085	COG1278	Cold shock
HQ400_09115	COG1028	Short-chain dehydrogenase reductase Sdr
HQ400_09120	COG3433	isochorismatase activity
HQ400_09120	COG1535	isochorismatase
HQ400_09130	COG1169	isochorismate synthase
HQ400_09135	COG4771	TonB-dependent receptor
HQ400_09140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ400_09150	COG0741	lytic transglycosylase activity
HQ400_09160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HQ400_09180	COG2911	Protein conserved in bacteria
HQ400_09185	COG0729	surface antigen
HQ400_09195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ400_09205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ400_09215	COG4134	Bacterial extracellular solute-binding protein
HQ400_09220	COG4135	transport system, permease component
HQ400_09225	COG4136	ATPase activity
HQ400_09230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQ400_09235	COG2951	lytic endotransglycosylase activity
HQ400_09240	COG0033	Phosphoglucomutase
HQ400_09245	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HQ400_09250	COG0596	Alpha beta hydrolase
HQ400_09265	COG0716	FMN binding
HQ400_09275	COG0735	belongs to the Fur family
HQ400_09280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ400_09290	COG2190	(PTS) system
HQ400_09290	COG1263	PTS System
HQ400_09290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ400_09295	COG0363	glucosamine-6-phosphate deaminase activity
HQ400_09300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ400_09305	COG1940	carbohydrate kinase activity
HQ400_09305	COG1846	Transcriptional regulator
HQ400_09315	COG2199	diguanylate cyclase activity
HQ400_09315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ400_09320	COG3275	phosphorelay sensor kinase activity
HQ400_09325	COG3279	Response regulator of the LytR AlgR family
HQ400_09330	COG1966	Carbon starvation protein
HQ400_09345	COG1566	PFAM secretion protein HlyD family protein
HQ400_09350	COG1061	Type III restriction enzyme res subunit
HQ400_09360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HQ400_09365	COG3021	interspecies interaction between organisms
HQ400_09375	COG1607	acyl-coa hydrolase
HQ400_09380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ400_09390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ400_09390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HQ400_09390	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ400_09390	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ400_09400	COG0633	Ferredoxin
HQ400_09400	COG3217	Mosc domain protein beta barrel domain protein
HQ400_09400	COG0633	Ferredoxin
HQ400_09400	COG3217	Mosc domain protein beta barrel domain protein
HQ400_09405	COG0501	Belongs to the peptidase M48B family
HQ400_09410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQ400_09415	COG1073	alpha beta
HQ400_09415	COG2226	methyltransferase
HQ400_09420	COG0156	8-amino-7-oxononanoate synthase activity
HQ400_09425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ400_09430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HQ400_09445	COG0017	Asparaginyl-tRNA synthetase
HQ400_09455	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ400_09465	COG1473	amidohydrolase
HQ400_09470	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ400_09480	COG1393	Belongs to the ArsC family
HQ400_09485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ400_09490	COG1876	peptidase activity
HQ400_09500	COG3263	regulation of cellular component size
HQ400_09545	COG1957	nucleoside hydrolase
HQ400_09550	COG0564	pseudouridine synthase activity
HQ400_09560	COG1454	alcohol dehydrogenase
HQ400_09565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ400_09570	COG0702	epimerase
HQ400_09580	COG0095	Lipoate-protein ligase
HQ400_09585	COG5001	Diguanylate cyclase
HQ400_09620	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ400_09630	COG1285	pathogenesis
HQ400_09635	COG0484	heat shock protein binding
HQ400_09640	COG0443	Heat shock 70 kDa protein
HQ400_09645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQ400_09650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQ400_09655	COG0497	DNA recombination
HQ400_09660	COG1227	inorganic diphosphatase activity
HQ400_09665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ400_09675	COG1538	Outer membrane efflux protein
HQ400_09680	COG3385	transposase activity
HQ400_09690	COG3385	transposase activity
HQ400_09730	COG3385	transposase activity
HQ400_09735	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HQ400_09740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ400_09755	COG0438	transferase activity, transferring glycosyl groups
HQ400_09780	COG0562	UDP-galactopyranose mutase
HQ400_09785	COG2244	polysaccharide biosynthetic process
HQ400_09800	COG1091	dTDP-4-dehydrorhamnose reductase activity
HQ400_09810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ400_09815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ400_09820	COG1309	transcriptional regulator
HQ400_09835	COG1342	Belongs to the UPF0251 family
HQ400_09855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ400_09880	COG0813	purine-nucleoside phosphorylase activity
HQ400_09905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ400_09910	COG0083	homoserine kinase activity
HQ400_09920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HQ400_09930	COG1946	Acyl-CoA thioesterase
HQ400_09940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HQ400_09945	COG1993	acr, cog1993
HQ400_09955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HQ400_09965	COG0009	L-threonylcarbamoyladenylate synthase
HQ400_09975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQ400_09980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ400_09980	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ400_09985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ400_09990	COG0135	phosphoribosylanthranilate isomerase activity
HQ400_09990	COG0134	indole-3-glycerol-phosphate synthase activity
HQ400_09995	COG0133	tryptophan synthase activity
HQ400_10000	COG0159	tryptophan synthase activity
HQ400_10005	COG3385	transposase activity
HQ400_10015	COG3385	transposase activity
HQ400_10025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ400_10035	COG0798	PFAM Bile acid sodium symporter
HQ400_10050	COG0640	Transcriptional regulator
HQ400_10065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ400_10075	COG0745	RESPONSE REGULATOR receiver
HQ400_10090	COG4988	ABC transporter
HQ400_10095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HQ400_10140	COG3161	chorismate lyase activity
HQ400_10150	COG3152	Membrane
HQ400_10165	COG3385	transposase activity
HQ400_10205	COG0531	amino acid
HQ400_10215	COG0531	amino acid
HQ400_10225	COG1283	sodium-dependent phosphate transmembrane transporter activity
HQ400_10235	COG2974	May be involved in recombination
HQ400_10250	COG0419	ATPase involved in DNA repair
HQ400_10255	COG3384	dioxygenase
HQ400_10265	COG0469	pyruvate kinase activity
HQ400_10270	COG1196	nuclear chromosome segregation
HQ400_10270	COG3264	Mechanosensitive ion channel
HQ400_10275	COG3706	GGDEF domain
HQ400_10280	COG2190	(PTS) system
HQ400_10290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_10295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HQ400_10300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQ400_10315	COG2770	Histidine kinase
HQ400_10315	COG3437	response regulator, receiver
HQ400_10320	COG3267	Type II secretory pathway component ExeA
HQ400_10320	COG3409	Peptidoglycan-binding domain 1 protein
HQ400_10345	COG1459	type II secretion system
HQ400_10350	COG2165	general secretion pathway protein
HQ400_10360	COG2165	general secretion pathway protein
HQ400_10365	COG4795	General secretion pathway protein
HQ400_10370	COG3156	type II secretion system protein K
HQ400_10380	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HQ400_10395	COG0670	Belongs to the BI1 family
HQ400_10400	COG1289	transmembrane transporter activity
HQ400_10405	COG2920	part of a sulfur-relay system
HQ400_10410	COG0673	inositol 2-dehydrogenase activity
HQ400_10435	COG3385	transposase activity
HQ400_10450	COG1032	radical SAM domain protein
HQ400_10460	COG1566	PFAM secretion protein HlyD family protein
HQ400_10465	COG3706	GGDEF domain
HQ400_10470	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ400_10475	COG0733	neurotransmitter:sodium symporter activity
HQ400_10495	COG2885	chlorophyll binding
HQ400_10495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HQ400_10500	COG0281	malic enzyme
HQ400_10525	COG3385	transposase activity
HQ400_10535	COG2233	PERMEase
HQ400_10540	COG1115	amino acid carrier protein
HQ400_10545	COG0019	diaminopimelate decarboxylase activity
HQ400_10565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HQ400_10580	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ400_10585	COG3142	Participates in the control of copper homeostasis
HQ400_10610	COG5002	protein histidine kinase activity
HQ400_10620	COG0346	lactoylglutathione lyase activity
HQ400_10635	COG0697	spore germination
HQ400_10695	COG0602	queuosine metabolic process
HQ400_10700	COG1328	CTP reductase activity
HQ400_10710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ400_10715	COG3115	cell septum assembly
HQ400_10720	COG1196	nuclear chromosome segregation
HQ400_10730	COG2860	membrane
HQ400_10740	COG3108	Peptidase M15
HQ400_10745	COG2989	Protein conserved in bacteria
HQ400_10760	COG0463	Glycosyl transferase, family 2
HQ400_10775	COG0366	Alpha amylase catalytic
HQ400_10810	COG2199	diguanylate cyclase activity
HQ400_10810	COG2203	Gaf domain
HQ400_10820	COG3590	peptidase
HQ400_10830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ400_10835	COG1982	Orn Lys Arg decarboxylase major
HQ400_10840	COG0531	amino acid
HQ400_10845	COG3710	Transcriptional regulator
HQ400_10850	COG0488	(ABC) transporter
HQ400_10860	COG0531	amino acid
HQ400_10880	COG0814	amino acid
HQ400_10940	COG3385	transposase activity
HQ400_10945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HQ400_10955	COG3091	SprT-like family
HQ400_10965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQ400_10985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQ400_11015	COG3385	transposase activity
HQ400_11030	COG3385	transposase activity
HQ400_11065	COG1115	amino acid carrier protein
HQ400_11070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ400_11080	COG0825	malonyl-CoA metabolic process
HQ400_11090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQ400_11095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ400_11100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ400_11105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ400_11110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ400_11120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ400_11125	COG0750	zinc metalloprotease
HQ400_11130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQ400_11135	COG0575	Belongs to the CDS family
HQ400_11145	COG0233	cytoplasmic translational termination
HQ400_11155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQ400_11160	COG0052	Belongs to the universal ribosomal protein uS2 family
HQ400_11165	COG0024	Methionine aminopeptidase
HQ400_11175	COG2171	N-acyltransferase activity
HQ400_11195	COG4580	involved in the transport of maltose and maltodextrins
HQ400_11200	COG0716	FMN binding
HQ400_11205	COG0564	pseudouridine synthase activity
HQ400_11210	COG3098	single-species biofilm formation
HQ400_11235	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HQ400_11255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HQ400_11315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HQ400_11325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ400_11325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ400_11340	COG1611	Belongs to the LOG family
HQ400_11345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ400_11350	COG0473	3-isopropylmalate dehydrogenase activity
HQ400_11360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HQ400_11365	COG2363	Small membrane protein
HQ400_11375	COG0583	DNA-binding transcription factor activity
HQ400_11380	COG0840	transmembrane signaling receptor activity
HQ400_11385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ400_11400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HQ400_11405	COG1666	GTP binding
HQ400_11420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ400_11435	COG0271	Belongs to the BolA IbaG family
HQ400_11440	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ400_11450	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ400_11455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ400_11460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ400_11465	COG2871	sodium ion transport
HQ400_11470	COG1477	protein flavinylation
HQ400_11500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ400_11515	COG0300	oxidoreductase activity
HQ400_11535	COG3272	Protein of unknown function (DUF1722)
HQ400_11565	COG0077	Prephenate dehydratase
HQ400_11565	COG1605	Chorismate mutase
HQ400_11590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HQ400_11635	COG3385	transposase activity
HQ400_11715	COG0300	oxidoreductase activity
HQ400_11740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HQ400_11755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HQ400_11760	COG0826	peptidase U32
HQ400_11765	COG1280	lysine exporter protein (LysE YggA)
HQ400_11775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ400_11785	COG0745	RESPONSE REGULATOR receiver
HQ400_11815	COG0835	chemotaxis
HQ400_11820	COG0840	transmembrane signaling receptor activity
HQ400_11830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HQ400_11835	COG2201	protein-glutamate methylesterase activity
HQ400_11840	COG1185	polyribonucleotide nucleotidyltransferase activity
HQ400_11845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQ400_11850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQ400_11855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQ400_11865	COG0195	Participates in both transcription termination and antitermination
HQ400_11870	COG0779	Required for maturation of 30S ribosomal subunits
HQ400_11885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HQ400_11890	COG0149	triose-phosphate isomerase activity
HQ400_11895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ400_11900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQ400_11915	COG1534	Rna-binding protein
HQ400_11935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ400_11940	COG1722	exodeoxyribonuclease VII activity
HQ400_11945	COG0142	geranyltranstransferase activity
HQ400_11960	COG0601	transmembrane transport
HQ400_11965	COG4166	transmembrane transport
HQ400_11975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HQ400_11980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQ400_11985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ400_12010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQ400_12020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQ400_12035	COG3381	protein complex oligomerization
HQ400_12055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ400_12060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQ400_12065	COG0511	ligase activity, forming carbon-carbon bonds
HQ400_12070	COG0439	Biotin carboxylase
HQ400_12075	COG3924	membrane
HQ400_12080	COG4145	pantothenate transmembrane transporter activity
HQ400_12085	COG2190	(PTS) system
HQ400_12085	COG1263	PTS System
HQ400_12085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ400_12095	COG0604	alcohol dehydrogenase
HQ400_12100	COG2264	protein methyltransferase activity
HQ400_12105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ400_12115	COG0778	Nitroreductase
HQ400_12120	COG1902	pentaerythritol trinitrate reductase activity
HQ400_12120	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ400_12125	COG0616	signal peptide processing
HQ400_12145	COG0848	biopolymer transport protein
HQ400_12150	COG0811	peptide transport
HQ400_12155	COG0811	peptide transport
HQ400_12170	COG3385	transposase activity
HQ400_12180	COG4174	ABC transporter (Permease)
HQ400_12185	COG4239	(ABC) transporter, permease
HQ400_12195	COG0444	Belongs to the ABC transporter superfamily
HQ400_12200	COG4608	Belongs to the ABC transporter superfamily
HQ400_12240	COG0741	lytic transglycosylase activity
HQ400_12255	COG0488	(ABC) transporter
HQ400_12265	COG2252	PERMEase
HQ400_12270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ400_12285	COG1278	Cold shock
HQ400_12325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HQ400_12330	COG1162	GTPase activity
HQ400_12335	COG0688	phosphatidylethanolamine metabolic process
HQ400_12340	COG4628	conserved protein (DUF2132)
HQ400_12375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HQ400_12380	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ400_12385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ400_12390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ400_12395	COG3178	'Phosphotransferase
HQ400_12400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HQ400_12405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ400_12410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ400_12415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQ400_12420	COG2967	ApaG domain
HQ400_12425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQ400_12435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ400_12440	COG3314	Sporulation integral membrane protein YlbJ
HQ400_12445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQ400_12450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQ400_12455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQ400_12460	COG0142	geranyltranstransferase activity
HQ400_12465	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HQ400_12470	COG0330	HflC and HflK could
HQ400_12475	COG0330	HflC and HflK could
HQ400_12480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQ400_12485	COG1923	regulation of RNA biosynthetic process
HQ400_12490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQ400_12495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQ400_12505	COG0802	atpase or kinase
HQ400_12510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQ400_12510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQ400_12535	COG2011	ABC-type metal ion transport system permease component
HQ400_12540	COG1464	Belongs to the NlpA lipoprotein family
HQ400_12575	COG0784	Response regulator, receiver
HQ400_12575	COG2198	Histidine kinase
HQ400_12575	COG5002	protein histidine kinase activity
HQ400_12610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQ400_12615	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HQ400_12620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ400_12625	COG2716	regulation of RNA biosynthetic process
HQ400_12630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQ400_12635	COG3013	Belongs to the UPF0304 family
HQ400_12645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ400_12650	COG0857	belongs to the CobB CobQ family
HQ400_12650	COG0280	phosphate acetyltransferase
HQ400_12655	COG1555	photosystem II stabilization
HQ400_12660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HQ400_12665	COG3104	oligopeptide transport
HQ400_12670	COG0745	RESPONSE REGULATOR receiver
HQ400_12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ400_12715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HQ400_12725	COG0745	RESPONSE REGULATOR receiver
HQ400_12735	COG5002	protein histidine kinase activity
HQ400_12775	COG2003	Belongs to the UPF0758 family
HQ400_12815	COG3311	Transcriptional regulator
HQ400_12825	COG3385	transposase activity
HQ400_12865	COG0440	acetolactate synthase activity
HQ400_12870	COG0028	Belongs to the TPP enzyme family
HQ400_12895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQ400_12900	COG0473	3-isopropylmalate dehydrogenase activity
HQ400_12905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQ400_12910	COG0066	3-isopropylmalate dehydratase activity
HQ400_12930	COG1178	ABC-type Fe3 transport system permease component
HQ400_12935	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HQ400_12940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HQ400_12990	COG0459	protein refolding
HQ400_12995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQ400_13000	COG0534	Mate efflux family protein
HQ400_13005	COG3030	protein affecting phage T7 exclusion by the F plasmid
HQ400_13010	COG1027	Aspartate ammonia-lyase
HQ400_13015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ400_13025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQ400_13030	COG1610	YqeY-like protein
HQ400_13040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ400_13060	COG0151	Belongs to the GarS family
HQ400_13065	COG0138	bifunctional purine biosynthesis protein purh
HQ400_13075	COG3036	rescue of stalled ribosome
HQ400_13080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ400_13085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQ400_13095	COG0673	inositol 2-dehydrogenase activity
HQ400_13105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ400_13120	COG0583	DNA-binding transcription factor activity
HQ400_13125	COG0477	Major facilitator Superfamily
HQ400_13135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ400_13150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HQ400_13165	COG0456	acetyltransferase
HQ400_13170	COG1022	Amp-dependent synthetase and ligase
HQ400_13175	COG2918	glutathione biosynthetic process
HQ400_13180	COG0612	Peptidase, M16
HQ400_13185	COG1238	metal cluster binding
HQ400_13210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ400_13215	COG0359	binds to the 23S rRNA
HQ400_13220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQ400_13225	COG0360	Binds together with S18 to 16S ribosomal RNA
HQ400_13230	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ400_13245	COG0776	regulation of translation
HQ400_13250	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HQ400_13260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HQ400_13275	COG0560	Phosphoserine phosphatase
HQ400_13285	COG0813	purine-nucleoside phosphorylase activity
HQ400_13290	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HQ400_13295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HQ400_13300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQ400_13310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ400_13315	COG0084	hydrolase, TatD family'
HQ400_13320	COG2165	general secretion pathway protein
HQ400_13325	COG1854	S-ribosylhomocysteine lyase activity
HQ400_13340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQ400_13340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ400_13345	COG4969	Belongs to the N-Me-Phe pilin family
HQ400_13390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQ400_13395	COG1047	Peptidyl-prolyl cis-trans
HQ400_13405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HQ400_13410	COG0196	riboflavin kinase activity
HQ400_13415	COG0728	peptidoglycan biosynthetic process
HQ400_13420	COG0268	Binds directly to 16S ribosomal RNA
HQ400_13425	COG0640	Transcriptional regulator
HQ400_13430	COG0583	DNA-binding transcription factor activity
HQ400_13440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ400_13445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ400_13450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQ400_13455	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HQ400_13460	COG1051	belongs to the nudix hydrolase family
HQ400_13475	COG0335	large ribosomal subunit rRNA binding
HQ400_13480	COG0336	Belongs to the RNA methyltransferase TrmD family
HQ400_13485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQ400_13490	COG0228	four-way junction DNA binding
HQ400_13495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQ400_13500	COG4137	Cytochrome C assembly protein
HQ400_13505	COG4536	flavin adenine dinucleotide binding
HQ400_13515	COG1017	nitric oxide dioxygenase activity
HQ400_13515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ400_13520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HQ400_13525	COG0039	L-malate dehydrogenase activity
HQ400_13530	COG4160	amino acid transport
HQ400_13535	COG4215	(ABC) transporter
HQ400_13540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_13545	COG1126	abc transporter atp-binding protein
HQ400_13550	COG1438	arginine binding
HQ400_13555	COG2837	iron assimilation
HQ400_13560	COG3842	ATPase activity
HQ400_13570	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ400_13575	COG0347	Belongs to the P(II) protein family
HQ400_13595	COG3022	response to hydroperoxide
HQ400_13610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQ400_13615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HQ400_13620	COG0762	integral membrane protein
HQ400_13625	COG1872	DUF167
HQ400_13635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ400_13640	COG0583	DNA-binding transcription factor activity
HQ400_13660	COG2610	gluconate transmembrane transporter activity
HQ400_13670	COG3112	Uncharacterised protein family (UPF0231)
HQ400_13700	COG0513	Belongs to the DEAD box helicase family
HQ400_13720	COG3385	transposase activity
HQ400_13745	COG1448	Aminotransferase
HQ400_13760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ400_13765	COG1328	CTP reductase activity
HQ400_13780	COG0543	2 iron, 2 sulfur cluster binding
HQ400_13780	COG0633	Ferredoxin
HQ400_13795	COG0840	transmembrane signaling receptor activity
HQ400_13800	COG3397	chitin binding
HQ400_13805	COG0583	DNA-binding transcription factor activity
HQ400_13810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HQ400_13815	COG4208	sulfate ABC transporter
HQ400_13820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HQ400_13830	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HQ400_13835	COG3174	membrane
HQ400_13840	COG0110	maltose O-acetyltransferase activity
HQ400_13855	COG1011	Hydrolase
HQ400_13860	COG0494	nUDIX hydrolase
HQ400_13865	COG1218	3'(2'),5'-bisphosphate nucleotidase
HQ400_13870	COG0814	amino acid
HQ400_13875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ400_13895	COG0460	homoserine dehydrogenase
HQ400_13895	COG0527	aspartate kinase activity
HQ400_13900	COG0306	phosphate transporter
HQ400_13905	COG1392	Phosphate transport regulator
HQ400_13910	COG3025	triphosphatase activity
HQ400_13915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ400_13925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ400_13930	COG0297	glycogen (starch) synthase activity
HQ400_13970	COG1757	Na H antiporter
HQ400_13975	COG0316	Belongs to the HesB IscA family
HQ400_13985	COG0038	chloride channel
HQ400_13990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ400_14055	COG1396	sequence-specific DNA binding
HQ400_14060	COG3135	benzoate transporter
HQ400_14085	COG0840	transmembrane signaling receptor activity
HQ400_14090	COG3047	cAMP biosynthetic process
HQ400_14105	COG0629	single-stranded DNA binding
HQ400_14110	COG3385	transposase activity
HQ400_14135	COG2376	Dihydroxyacetone kinase
HQ400_14140	COG1461	Dihydroxyacetone kinase
HQ400_14155	COG3284	Transcriptional regulator
HQ400_14160	COG2957	Belongs to the agmatine deiminase family
HQ400_14170	COG0628	permease
HQ400_14175	COG0494	nUDIX hydrolase
HQ400_14195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ400_14220	COG0456	acetyltransferase
HQ400_14225	COG3133	Outer membrane lipoprotein
HQ400_14230	COG0004	ammonium transporteR
HQ400_14245	COG3932	Exopolysaccharide synthesis, ExoD
HQ400_14250	COG0814	amino acid
HQ400_14255	COG3385	transposase activity
HQ400_14275	COG0110	maltose O-acetyltransferase activity
HQ400_14295	COG3385	transposase activity
HQ400_14315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ400_14320	COG2022	thiamine diphosphate biosynthetic process
HQ400_14330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ400_14335	COG0352	thiamine-phosphate diphosphorylase activity
HQ400_14340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HQ400_14360	COG0745	RESPONSE REGULATOR receiver
HQ400_14365	COG0642	Histidine kinase
HQ400_14370	COG0189	ligase activity
HQ400_14375	COG0646	methionine synthase
HQ400_14375	COG1410	methionine synthase
HQ400_14390	COG2169	Transcriptional regulator
HQ400_14400	COG2211	Major facilitator Superfamily
HQ400_14405	COG1486	melibiose metabolic process
HQ400_14435	COG0477	Major facilitator Superfamily
HQ400_14450	COG0312	modulator of DNA gyrase
HQ400_14455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ400_14465	COG3164	Protein of unknown function
HQ400_14470	COG1530	ribonuclease E activity
HQ400_14475	COG0424	maF-like protein
HQ400_14480	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HQ400_14485	COG1792	Involved in formation and maintenance of cell shape
HQ400_14490	COG1077	Cell shape determining protein MreB Mrl
HQ400_14515	COG4968	Prepilin-type N-terminal cleavage methylation domain
HQ400_14535	COG1459	type II secretion system
HQ400_14540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ400_14555	COG1450	Type ii and iii secretion system protein
HQ400_14585	COG2199	diguanylate cyclase activity
HQ400_14585	COG2200	EAL domain
HQ400_14590	COG2200	EAL domain
HQ400_14600	COG0387	Pfam Sodium calcium exchanger
HQ400_14605	COG2986	histidine ammonia-lyase
HQ400_14610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQ400_14615	COG0010	Belongs to the arginase family
HQ400_14625	COG2188	Transcriptional regulator
HQ400_14630	COG0288	reversible hydration of carbon dioxide
HQ400_14640	COG2177	Part of the ABC transporter FtsEX involved in
HQ400_14650	COG0552	protein localization to endoplasmic reticulum
HQ400_14655	COG0742	ribosomal rna small subunit methyltransferase
HQ400_14680	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ400_14685	COG0583	DNA-binding transcription factor activity
HQ400_14690	COG4221	oxidoreductase activity
HQ400_14705	COG1770	oligopeptidase
HQ400_14720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ400_14730	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ400_14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ400_14750	COG2095	MarC family integral membrane protein
HQ400_14760	COG1301	dicarboxylic acid transport
HQ400_14785	COG3714	YhhN family
HQ400_14835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ400_14840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ400_14845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQ400_14850	COG0049	tRNA binding
HQ400_14855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQ400_14860	COG2168	tRNA wobble position uridine thiolation
HQ400_14865	COG2923	Belongs to the DsrF TusC family
HQ400_14870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ400_14880	COG2964	Protein conserved in bacteria
HQ400_14885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQ400_14890	COG0085	RNA polymerase activity
HQ400_14895	COG0222	ribosome binding
HQ400_14900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQ400_14905	COG0081	regulation of translation
HQ400_14910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQ400_14915	COG0250	Participates in transcription elongation, termination and antitermination
HQ400_14930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ400_14955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQ400_14960	COG0569	domain protein
HQ400_14965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ400_14970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQ400_14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_14980	COG4191	Histidine kinase
HQ400_14985	COG3005	denitrification pathway
HQ400_14990	COG0243	molybdopterin cofactor binding
HQ400_15020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HQ400_15025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HQ400_15035	COG2204	response regulator
HQ400_15045	COG2205	protein histidine kinase activity
HQ400_15065	COG5413	integral membrane protein
HQ400_15075	COG1522	sequence-specific DNA binding
HQ400_15080	COG2502	aspartate--ammonia ligase
HQ400_15085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ400_15090	COG0542	response to heat
HQ400_15100	COG0564	pseudouridine synthase activity
HQ400_15105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ400_15130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ400_15135	COG0463	Glycosyl transferase, family 2
HQ400_15140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ400_15140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ400_15145	COG0726	polysaccharide deacetylase
HQ400_15155	COG2076	Multidrug Resistance protein
HQ400_15160	COG2076	Multidrug Resistance protein
HQ400_15185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HQ400_15190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HQ400_15195	COG1979	alcohol dehydrogenase
HQ400_15205	COG3040	lipid binding
HQ400_15220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HQ400_15260	COG0540	Belongs to the ATCase OTCase family
HQ400_15265	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HQ400_15270	COG1438	arginine binding
HQ400_15275	COG1288	antiporter activity
HQ400_15320	COG3078	GTPase activator activity
HQ400_15330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQ400_15345	COG0408	coproporphyrinogen oxidase activity
HQ400_15350	COG0009	L-threonylcarbamoyladenylate synthase
HQ400_15360	COG0551	DNA topoisomerase type I activity
HQ400_15365	COG2922	Belongs to the Smg family
HQ400_15370	COG0758	DNA mediated transformation
HQ400_15375	COG1652	LysM domain
HQ400_15380	COG0242	peptide deformylase activity
HQ400_15385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ400_15390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ400_15390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ400_15395	COG0569	domain protein
HQ400_15410	COG0203	ribosomal protein L17
HQ400_15415	COG0202	RNA polymerase activity
HQ400_15420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQ400_15425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQ400_15430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQ400_15435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ400_15440	COG0201	protein transport
HQ400_15445	COG0200	Binds to the 23S rRNA
HQ400_15450	COG1841	ribosomal large subunit assembly
HQ400_15455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQ400_15460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQ400_15465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQ400_15470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQ400_15475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQ400_15480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQ400_15485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQ400_15490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQ400_15495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQ400_15500	COG0255	Belongs to the universal ribosomal protein uL29 family
HQ400_15505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQ400_15510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQ400_15515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQ400_15520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQ400_15525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQ400_15530	COG0089	rRNA binding
HQ400_15535	COG0088	Forms part of the polypeptide exit tunnel
HQ400_15540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQ400_15545	COG0051	transcription antitermination factor activity, RNA binding
HQ400_15565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ400_15570	COG2183	response to ionizing radiation
HQ400_15590	COG0596	Alpha beta hydrolase
HQ400_15595	COG1040	competence protein
HQ400_15600	COG0316	Belongs to the HesB IscA family
HQ400_15600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ400_15605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQ400_15610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HQ400_15615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ400_15620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ400_15625	COG4942	peptidase
HQ400_15635	COG1609	Transcriptional regulator
HQ400_15650	COG0800	Aldolase
HQ400_15660	COG3265	gluconokinase activity
HQ400_15665	COG2610	gluconate transmembrane transporter activity
HQ400_15670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ400_15685	COG0456	acetyltransferase
HQ400_15690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HQ400_15695	COG1490	D-aminoacyl-tRNA deacylase activity
HQ400_15700	COG1295	ribonuclease BN
HQ400_15705	COG0281	malic enzyme
HQ400_15715	COG0702	epimerase
HQ400_15725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQ400_15730	COG0254	rRNA binding
HQ400_15745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ400_15750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HQ400_15760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQ400_15770	COG0514	ATP-dependent DNA helicase (RecQ)
HQ400_15775	COG2050	protein possibly involved in aromatic compounds catabolism
HQ400_15790	COG2258	MOSC domain
HQ400_15795	COG1177	transmembrane transport
HQ400_15800	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ400_15805	COG3842	ATPase activity
HQ400_15825	COG0174	glutamine synthetase
HQ400_15845	COG3045	CreA protein
HQ400_15850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ400_15855	COG0443	Heat shock 70 kDa protein
HQ400_15870	COG0366	Alpha amylase catalytic
HQ400_15885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ400_15895	COG4211	Belongs to the binding-protein-dependent transport system permease family
HQ400_15915	COG1609	Transcriptional regulator
HQ400_15920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ400_15925	COG1085	galactose-1-phosphate uridylyltransferase
HQ400_15930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HQ400_15935	COG2017	converts alpha-aldose to the beta-anomer
HQ400_15940	COG1968	undecaprenyl-diphosphatase activity
HQ400_15950	COG1595	DNA-templated transcription, initiation
HQ400_15970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HQ400_15975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HQ400_15985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ400_15995	COG0842	Transport permease protein
HQ400_16000	COG0842	Transport permease protein
HQ400_16005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ400_16015	COG2116	formate transmembrane transporter activity
HQ400_16025	COG2239	Acts as a magnesium transporter
HQ400_16030	COG0737	Belongs to the 5'-nucleotidase family
HQ400_16035	COG1079	Belongs to the binding-protein-dependent transport system permease family
HQ400_16040	COG4603	Belongs to the binding-protein-dependent transport system permease family
HQ400_16045	COG3845	ABC transporter
HQ400_16050	COG1744	ABC transporter substrate-binding protein PnrA-like
HQ400_16070	COG0210	DNA helicase
HQ400_16115	COG1280	lysine exporter protein (LysE YggA)
HQ400_16145	COG3385	transposase activity
HQ400_16150	COG3306	glycosyltransferase involved in LPS biosynthesis
HQ400_16165	COG0438	transferase activity, transferring glycosyl groups
HQ400_16170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ400_16180	COG0156	8-amino-7-oxononanoate synthase activity
HQ400_16185	COG1063	alcohol dehydrogenase
HQ400_16190	COG3245	cytochrome
HQ400_16205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQ400_16210	COG2166	iron-sulfur cluster assembly
HQ400_16215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HQ400_16255	COG4206	TonB-dependent receptor
HQ400_16260	COG0583	DNA-binding transcription factor activity
HQ400_16275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQ400_16285	COG2223	nitrite transmembrane transporter activity
HQ400_16290	COG3279	Response regulator of the LytR AlgR family
HQ400_16300	COG2081	HI0933 family
HQ400_16305	COG1528	Iron-storage protein
HQ400_16310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ400_16315	COG0589	response to stress
HQ400_16355	COG3642	lipopolysaccharide core region biosynthetic process
HQ400_16360	COG0859	PFAM glycosyl transferase family 9
HQ400_16365	COG0194	GDP metabolic process
HQ400_16370	COG1758	RNA polymerase activity
HQ400_16375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ400_16380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ400_16385	COG2267	carboxylic ester hydrolase activity
HQ400_16390	COG0561	phosphatase activity
HQ400_16425	COG1309	transcriptional regulator
HQ400_16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ400_16435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ400_16440	COG4191	Histidine kinase
HQ400_16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_16445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ400_16470	COG0745	RESPONSE REGULATOR receiver
HQ400_16475	COG3385	transposase activity
HQ400_16480	COG2814	Major facilitator Superfamily
HQ400_16490	COG3977	Valine--pyruvate aminotransferase
HQ400_16495	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ400_16500	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ400_16505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ400_16535	COG0592	DNA-directed DNA polymerase activity
HQ400_16555	COG1126	abc transporter atp-binding protein
HQ400_16560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQ400_16565	COG0594	ribonuclease P activity
HQ400_16570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQ400_16575	COG0706	membrane insertase activity
HQ400_16580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQ400_16585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HQ400_16590	COG0445	tRNA wobble uridine modification
HQ400_16595	COG0357	Ribosomal RNA small subunit methyltransferase G
HQ400_16600	COG1192	Involved in chromosome partitioning
HQ400_16605	COG1475	DNA binding
HQ400_16615	COG0356	it plays a direct role in the translocation of protons across the membrane
HQ400_16625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQ400_16630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ400_16635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQ400_16640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQ400_16645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQ400_16650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQ400_16655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ400_16660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ400_16710	COG0297	glycogen (starch) synthase activity
HQ400_16710	COG0438	transferase activity, transferring glycosyl groups
HQ400_16725	COG4452	Inner membrane protein CreD
HQ400_16740	COG2205	protein histidine kinase activity
HQ400_16745	COG0745	RESPONSE REGULATOR receiver
HQ400_16750	COG1349	DNA-binding transcription factor activity
HQ400_16755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQ400_16760	COG2771	luxR family
HQ400_16770	COG0811	peptide transport
HQ400_16775	COG0811	peptide transport
HQ400_16780	COG0848	biopolymer transport protein
HQ400_16785	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ400_16820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HQ400_16825	COG0402	S-adenosylhomocysteine deaminase activity
HQ400_16830	COG2226	methyltransferase
HQ400_16850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ400_16855	COG0805	protein transport
HQ400_16860	COG0084	hydrolase, TatD family'
HQ400_16875	COG3469	chitinase activity
HQ400_16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ400_16895	COG0742	ribosomal rna small subunit methyltransferase
HQ400_16905	COG0248	Ppx GppA phosphatase
HQ400_16910	COG0513	Belongs to the DEAD box helicase family
HQ400_16915	COG3118	belongs to the thioredoxin family
HQ400_16930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HQ400_16945	COG2960	long-chain fatty acid transporting porin activity
HQ400_16960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ400_17010	COG2203	Gaf domain
HQ400_17010	COG5001	Diguanylate cyclase
HQ400_17010	COG4251	negative regulation of phosphorylation
HQ400_17010	COG3706	GGDEF domain
HQ400_17015	COG3385	transposase activity
HQ400_17030	COG0751	glycine-tRNA ligase activity
HQ400_17035	COG0752	glycyl-tRNA synthetase alpha subunit
HQ400_17040	COG2818	Glycosylase
HQ400_17055	COG0251	oxidation-reduction process
HQ400_17060	COG0425	Belongs to the sulfur carrier protein TusA family
HQ400_17085	COG0183	Belongs to the thiolase family
HQ400_17095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ400_17105	COG1739	Uncharacterized protein family UPF0029
HQ400_17110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ400_17115	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HQ400_17165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQ400_17170	COG0166	Belongs to the GPI family
HQ400_17175	COG0668	transmembrane transport
HQ400_17180	COG1309	transcriptional regulator
HQ400_17185	COG0756	dUTP diphosphatase activity
HQ400_17190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HQ400_17195	COG2003	Belongs to the UPF0758 family
HQ400_17200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQ400_17205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQ400_17215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HQ400_17220	COG2990	Protein conserved in bacteria
HQ400_17225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQ400_17230	COG0859	PFAM glycosyl transferase family 9
HQ400_17235	COG0463	Glycosyl transferase, family 2
HQ400_17240	COG0859	PFAM glycosyl transferase family 9
HQ400_17245	COG1519	Transferase
HQ400_17260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_17265	COG1609	Transcriptional regulator
HQ400_17270	COG0604	alcohol dehydrogenase
HQ400_17285	COG1580	Controls the rotational direction of flagella during chemotaxis
HQ400_17290	COG3161	chorismate lyase activity
HQ400_17295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HQ400_17300	COG2937	Belongs to the GPAT DAPAT family
HQ400_17305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQ400_17325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HQ400_17330	COG2205	protein histidine kinase activity
HQ400_17335	COG0745	RESPONSE REGULATOR receiver
HQ400_17345	COG1045	serine acetyltransferase
HQ400_17355	COG3074	FtsZ-dependent cytokinesis
HQ400_17360	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HQ400_17365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ400_17365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ400_17370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HQ400_17410	COG3250	beta-galactosidase activity
HQ400_17415	COG2731	YhcH YjgK YiaL family protein
HQ400_17420	COG0531	amino acid
HQ400_17425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ400_17435	COG0385	Bile acid
HQ400_17440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ400_17460	COG0583	DNA-binding transcription factor activity
HQ400_17465	COG1561	YicC-like family, N-terminal region
HQ400_17470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HQ400_17475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQ400_17490	COG5001	Diguanylate cyclase
HQ400_17490	COG4251	negative regulation of phosphorylation
HQ400_17490	COG3706	GGDEF domain
HQ400_17490	COG2203	Gaf domain
HQ400_17495	COG3084	Protein conserved in bacteria
HQ400_17510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ400_17520	COG1335	isochorismatase
HQ400_17530	COG1683	Conserved Protein
HQ400_17535	COG0204	Acyl-transferase
HQ400_17540	COG0204	Acyl-transferase
HQ400_17545	COG0606	chelatase, subunit chli
HQ400_17555	COG3978	acetolactate synthase activity
HQ400_17565	COG0129	dihydroxy-acid dehydratase activity
HQ400_17580	COG1401	restriction endodeoxyribonuclease activity
HQ400_17585	COG1401	restriction endodeoxyribonuclease activity
HQ400_17630	COG2391	methyltransferase activity
HQ400_17635	COG2962	Rard protein
HQ400_17650	COG1396	sequence-specific DNA binding
HQ400_17655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HQ400_17670	COG0583	DNA-binding transcription factor activity
HQ400_17675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ400_17695	COG1322	Protein conserved in bacteria
HQ400_17700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HQ400_17705	COG2204	response regulator
HQ400_17720	COG0174	glutamine synthetase
HQ400_17725	COG1217	gtp-binding protein TYPA
HQ400_17765	COG4771	TonB-dependent receptor
HQ400_17800	COG0583	DNA-binding transcription factor activity
HQ400_17810	COG1741	Belongs to the pirin family
HQ400_17815	COG2259	Doxx family
HQ400_17840	COG2199	diguanylate cyclase activity
HQ400_17840	COG2203	Gaf domain
HQ400_17855	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ400_17880	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ400_17890	COG3842	ATPase activity
HQ400_17920	COG2873	o-acetylhomoserine
HQ400_17950	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HQ400_17955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ400_17980	COG0456	acetyltransferase
HQ400_17980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HQ400_17985	COG0456	acetyltransferase
HQ400_17985	COG0454	-acetyltransferase
HQ400_18010	COG2927	DNA polymerase III (CHI subunit)
HQ400_18015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ400_18020	COG0795	lipopolysaccharide-transporting ATPase activity
HQ400_18025	COG0795	lipopolysaccharide-transporting ATPase activity
HQ400_18040	COG0582	viral genome integration into host DNA
HQ400_18080	COG3385	transposase activity
HQ400_18120	COG1686	Belongs to the peptidase S11 family
HQ400_18155	COG1494	fructose-1,6-bisphosphatase
HQ400_18170	COG2959	enzyme of heme biosynthesis
HQ400_18180	COG0181	hydroxymethylbilane synthase activity
HQ400_18190	COG0400	carboxylic ester hydrolase activity
HQ400_18195	COG1965	Belongs to the frataxin family
HQ400_18205	COG0019	diaminopimelate decarboxylase activity
HQ400_18225	COG1011	Hydrolase
HQ400_18230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ400_18240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HQ400_18245	COG3028	Belongs to the UPF0307 family
HQ400_18250	COG0312	modulator of DNA gyrase
HQ400_18255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQ400_18260	COG5007	Belongs to the BolA IbaG family
HQ400_18270	COG2854	intermembrane phospholipid transfer
HQ400_18275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ400_18280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ400_18285	COG1127	ABC transporter
HQ400_18290	COG0517	IMP dehydrogenase activity
HQ400_18290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ400_18295	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQ400_18305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HQ400_18310	COG1137	ATPase activity
HQ400_18315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQ400_18325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_18330	COG1660	Displays ATPase and GTPase activities
HQ400_18335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_18340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_18340	COG3711	transcriptional antiterminator
HQ400_18355	COG3964	amidohydrolase
HQ400_18385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ400_18390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ400_18400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HQ400_18405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQ400_18410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQ400_18415	COG0723	plastoquinol--plastocyanin reductase activity
HQ400_18420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HQ400_18425	COG2857	Cytochrome c1
HQ400_18430	COG0625	glutathione transferase activity
HQ400_18435	COG2969	positive regulation of protein catabolic process
HQ400_18445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ400_18450	COG0792	nuclease activity
HQ400_18455	COG3107	peptidoglycan biosynthetic process
HQ400_18510	COG1677	Flagellar hook-basal body complex protein FliE
HQ400_18520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ400_18545	COG2747	anti-sigma28 factor FlgM
HQ400_18555	COG1815	bacterial-type flagellum-dependent cell motility
HQ400_18580	COG4786	Flagellar basal body rod
HQ400_18585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ400_18590	COG1706	bacterial-type flagellum-dependent cell motility
HQ400_18600	COG1256	bacterial-type flagellum assembly
HQ400_18600	COG4786	Flagellar basal body rod
HQ400_18605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ400_18615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ400_18620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ400_18625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HQ400_18650	COG1191	sigma factor activity
HQ400_18655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ400_18660	COG1360	Flagellar Motor Protein
HQ400_18665	COG0741	lytic transglycosylase activity
HQ400_18665	COG1388	LysM domain
HQ400_18675	COG2001	Belongs to the MraZ family
HQ400_18680	COG0275	rRNA processing
HQ400_18685	COG3116	cell division
HQ400_18690	COG0768	penicillin binding
HQ400_18695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ400_18700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQ400_18705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ400_18710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQ400_18715	COG0772	Belongs to the SEDS family
HQ400_18720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQ400_18725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ400_18735	COG0849	cell division
HQ400_18740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQ400_18745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQ400_18755	COG0653	protein targeting
HQ400_18765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HQ400_18770	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HQ400_18785	COG1459	type II secretion system
HQ400_18790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ400_18815	COG2186	Transcriptional regulator
HQ400_18820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HQ400_18825	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ400_18830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ400_18840	COG0840	transmembrane signaling receptor activity
HQ400_18845	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ400_18850	COG1049	propionate catabolic process, 2-methylcitrate cycle
HQ400_18855	COG2200	EAL domain
HQ400_18865	COG0523	cobalamin synthesis protein
HQ400_18870	COG0477	Major facilitator Superfamily
HQ400_18885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HQ400_18890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQ400_18915	COG3314	Sporulation integral membrane protein YlbJ
HQ400_18930	COG0165	Argininosuccinate lyase
HQ400_18945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ400_18960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQ400_18970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HQ400_18985	COG0583	DNA-binding transcription factor activity
HQ400_19005	COG1380	Effector of murein hydrolase LrgA
HQ400_19010	COG1346	cytolysis
HQ400_19020	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ400_19025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ400_19030	COG0582	viral genome integration into host DNA
HQ400_19035	COG3385	transposase activity
HQ400_19075	COG3385	transposase activity
HQ400_19090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ400_19135	COG1518	maintenance of DNA repeat elements
HQ400_19190	COG5377	YqaJ viral recombinase family
HQ400_19200	COG3385	transposase activity
HQ400_19205	COG1546	Belongs to the CinA family
HQ400_19210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ400_19220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQ400_19225	COG0527	aspartate kinase activity
HQ400_19230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HQ400_19270	COG1686	Belongs to the peptidase S11 family
HQ400_19275	COG0586	Pfam SNARE associated Golgi protein
HQ400_19280	COG1253	flavin adenine dinucleotide binding
HQ400_19285	COG0252	asparaginase activity
HQ400_19300	COG1609	Transcriptional regulator
HQ400_19305	COG1263	PTS System
HQ400_19305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ400_19310	COG0366	Alpha amylase catalytic
HQ400_19315	COG0110	maltose O-acetyltransferase activity
HQ400_19325	COG0564	pseudouridine synthase activity
HQ400_19330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ400_19360	COG2926	Belongs to the UPF0265 family
HQ400_19370	COG0561	phosphatase activity
HQ400_19385	COG1418	mRNA catabolic process
HQ400_19390	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HQ400_19400	COG1522	sequence-specific DNA binding
HQ400_19405	COG1368	sulfuric ester hydrolase activity
HQ400_19425	COG1285	pathogenesis
HQ400_19445	COG4221	oxidoreductase activity
HQ400_19465	COG1803	Methylglyoxal synthase
HQ400_19485	COG1444	tRNA N-acetyltransferase activity
HQ400_19495	COG0835	chemotaxis
HQ400_19495	COG0784	Response regulator, receiver
HQ400_19500	COG2949	membrane
HQ400_19505	COG3291	Pkd domain containing protein
HQ400_19525	COG0596	Alpha beta hydrolase
HQ400_19535	COG1169	isochorismate synthase
HQ400_19540	COG1575	Belongs to the MenA family. Type 1 subfamily
HQ400_19560	COG0513	Belongs to the DEAD box helicase family
HQ400_19570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ400_19575	COG1988	membrane-bound metal-dependent
HQ400_19590	COG1671	Belongs to the UPF0178 family
HQ400_19620	COG0246	Mannitol dehydrogenase
HQ400_19625	COG2213	PTS system mannitol-specific
HQ400_19625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_19630	COG1560	Kdo2-lipid A biosynthetic process
HQ400_19635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ400_19635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ400_19640	COG1538	Outer membrane efflux protein
HQ400_19645	COG0494	nUDIX hydrolase
HQ400_19650	COG3151	Protein conserved in bacteria
HQ400_19660	COG3150	esterase
HQ400_19675	COG1566	PFAM secretion protein HlyD family protein
HQ400_19680	COG1289	transmembrane transporter activity
HQ400_19685	COG0187	DNA topoisomerase II activity
HQ400_19705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ400_19755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ400_19775	COG0204	Acyl-transferase
HQ400_19780	COG1842	Phage shock protein A
HQ400_19795	COG2827	Endonuclease containing a URI domain
HQ400_19810	COG1573	uracil-dna glycosylase
HQ400_19815	COG0697	spore germination
HQ400_19820	COG0583	DNA-binding transcription factor activity
HQ400_19825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HQ400_19830	COG1121	(ABC) transporter
HQ400_19835	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HQ400_19855	COG0739	heme binding
HQ400_19865	COG3068	Protein conserved in bacteria
HQ400_19885	COG0617	tRNA 3'-terminal CCA addition
HQ400_19890	COG1194	a g-specific adenine glycosylase
HQ400_19895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HQ400_19910	COG3240	lipase activity
HQ400_19920	COG3706	GGDEF domain
HQ400_19925	COG0557	exoribonuclease II activity
HQ400_19930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ400_19940	COG2153	protein acetylation
HQ400_19945	COG0513	Belongs to the DEAD box helicase family
HQ400_19975	COG0735	belongs to the Fur family
HQ400_19980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ400_20000	COG0110	maltose O-acetyltransferase activity
HQ400_20010	COG1024	Enoyl-CoA hydratase
HQ400_20025	COG4221	oxidoreductase activity
HQ400_20030	COG0442	prolyl-tRNA aminoacylation
HQ400_20035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ400_20040	COG3009	Protein conserved in bacteria
HQ400_20050	COG2995	paraquat-inducible protein a
HQ400_20070	COG2203	Gaf domain
HQ400_20070	COG3706	GGDEF domain
HQ400_20070	COG4251	negative regulation of phosphorylation
HQ400_20070	COG5001	Diguanylate cyclase
HQ400_20075	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HQ400_20090	COG2771	luxR family
HQ400_20100	COG0840	transmembrane signaling receptor activity
HQ400_20105	COG0632	four-way junction helicase activity
HQ400_20110	COG2255	four-way junction helicase activity
HQ400_20115	COG1271	oxidase subunit
HQ400_20120	COG1294	oxidase, subunit
HQ400_20125	COG4890	Cyd operon protein YbgT
HQ400_20130	COG3790	cyd operon protein YbgE
HQ400_20135	COG0824	Thioesterase
HQ400_20140	COG0811	peptide transport
HQ400_20155	COG0823	Involved in the tonB-independent uptake of proteins
HQ400_20160	COG2885	chlorophyll binding
HQ400_20165	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HQ400_20230	COG0733	neurotransmitter:sodium symporter activity
HQ400_20240	COG0733	neurotransmitter:sodium symporter activity
HQ400_20255	COG0561	phosphatase activity
HQ400_20280	COG1051	belongs to the nudix hydrolase family
HQ400_20300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ400_20310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ400_20320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQ400_20325	COG0840	transmembrane signaling receptor activity
HQ400_20330	COG1585	Membrane protein implicated in regulation of membrane protease activity
HQ400_20335	COG0330	HflC and HflK could
HQ400_20340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ400_20340	COG1648	precorrin-2 dehydrogenase activity
HQ400_20345	COG0175	sulfate reduction
HQ400_20350	COG2895	sulfate adenylyltransferase (ATP) activity
HQ400_20355	COG0529	Catalyzes the synthesis of activated sulfate
HQ400_20360	COG3385	transposase activity
HQ400_20375	COG0840	transmembrane signaling receptor activity
HQ400_20410	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HQ400_20425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQ400_20430	COG0784	Response regulator, receiver
HQ400_20430	COG3437	response regulator, receiver
HQ400_20440	COG2076	Multidrug Resistance protein
HQ400_20445	COG2076	Multidrug Resistance protein
HQ400_20450	COG0346	lactoylglutathione lyase activity
HQ400_20455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ400_20460	COG1643	Atp-dependent helicase
HQ400_20470	COG1489	DNA binding
HQ400_20475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ400_20480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ400_20490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HQ400_20495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQ400_20500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQ400_20530	COG1924	4 iron, 4 sulfur cluster binding
HQ400_20540	COG0842	Transport permease protein
HQ400_20545	COG1131	(ABC) transporter
HQ400_20560	COG0163	prenyltransferase activity
HQ400_20565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ400_20570	COG0671	phosphoesterase, PA-phosphatase related
HQ400_20575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ400_20580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ400_20585	COG1151	hydroxylamine reductase activity
HQ400_20590	COG0783	Belongs to the Dps family
HQ400_20595	COG3023	N-Acetylmuramoyl-L-alanine amidase
HQ400_20600	COG4807	Protein conserved in bacteria
HQ400_20610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ400_20615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ400_20620	COG3956	TIGRFAM MazG family protein
HQ400_20625	COG0504	CTP synthase activity
HQ400_20630	COG0148	phosphopyruvate hydratase activity
HQ400_20640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ400_20660	COG0789	Transcriptional regulator
HQ400_20680	COG0583	DNA-binding transcription factor activity
HQ400_20685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HQ400_20695	COG0488	(ABC) transporter
HQ400_20715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ400_20730	COG1794	racemase activity, acting on amino acids and derivatives
HQ400_20740	COG2731	YhcH YjgK YiaL family protein
HQ400_20750	COG0668	transmembrane transport
HQ400_20755	COG1376	ErfK ybiS ycfS ynhG family protein
HQ400_20765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ400_20770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HQ400_20775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HQ400_20785	COG0585	pseudouridine synthase activity
HQ400_20790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQ400_20795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQ400_20800	COG1238	metal cluster binding
HQ400_20805	COG4942	peptidase
HQ400_20805	COG1388	LysM domain
HQ400_20815	COG1902	pentaerythritol trinitrate reductase activity
HQ400_20830	COG2957	Belongs to the agmatine deiminase family
HQ400_20855	COG0471	metal ion transport
HQ400_20875	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HQ400_20880	COG1858	cytochrome C peroxidase
HQ400_20920	COG2816	NAD+ diphosphatase activity
HQ400_20930	COG4191	Histidine kinase
HQ400_20955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HQ400_20970	COG4991	sh3 domain protein
HQ400_20985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQ400_20990	COG1940	carbohydrate kinase activity
HQ400_20995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ400_21000	COG0126	phosphoglycerate kinase activity
HQ400_21010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ400_21055	COG0354	folic acid binding
HQ400_21070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQ400_21075	COG1595	DNA-templated transcription, initiation
HQ400_21080	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HQ400_21085	COG3026	antisigma factor binding
HQ400_21095	COG0481	GTPase activity
HQ400_21100	COG0681	Belongs to the peptidase S26 family
HQ400_21115	COG1381	Involved in DNA repair and RecF pathway recombination
HQ400_21120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQ400_21130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ400_21135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ400_21140	COG3716	PTS system mannose fructose sorbose family IID component
HQ400_21150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ400_21165	COG1349	DNA-binding transcription factor activity
HQ400_21180	COG2917	probably involved in intracellular septation
HQ400_21185	COG0076	glutamate decarboxylase activity
HQ400_21245	COG0556	nucleotide-excision repair
HQ400_21290	COG3385	transposase activity
HQ400_21300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ400_21300	COG1372	Participates in initiation and elongation during chromosome replication
HQ400_21320	COG0776	regulation of translation
HQ400_21410	COG3550	peptidyl-serine autophosphorylation
HQ400_21435	COG0419	ATPase involved in DNA repair
HQ400_21475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ400_21525	COG5642	Protein of unknown function (DUF2384)
HQ400_21595	COG4974	Belongs to the 'phage' integrase family
HQ400_21605	COG3385	transposase activity
HQ400_21615	COG3385	transposase activity
HQ400_21620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ400_21620	COG1372	Participates in initiation and elongation during chromosome replication
HQ400_21640	COG3385	transposase activity
HQ400_21715	COG1192	Involved in chromosome partitioning
HQ400_21755	COG0358	DNA primase activity
HQ400_21775	COG1923	regulation of RNA biosynthetic process
HQ400_21800	COG5301	cellulose 1,4-beta-cellobiosidase activity