locus-tag	class	description
E4185_00010	ENOG4105XIQ	Protein of unknown function (DUF2517)
E4185_00045	ENOG4105ENX	hydrolase
E4185_00055	ENOG4107RTG	Major Facilitator superfamily
E4185_00080	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E4185_00090	ENOG4108T0W	nitrous oxide maturation protein NosY
E4185_00095	ENOG4105CIG	ABC transporter
E4185_00125	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4185_00140	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
E4185_00145	ENOG4107TT5	NLP P60 protein
E4185_00150	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
E4185_00155	ENOG4107QR8	Thioredoxin
E4185_00165	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E4185_00170	ENOG4105CIY	formyltetrahydrofolate deformylase
E4185_00195	ENOG4105E4C	Lytic transglycosylase catalytic
E4185_00200	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4185_00205	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
E4185_00210	ENOG4105EP9	oxidoreductase
E4185_00225	ENOG410600T	transposase
E4185_00240	ENOG4105CCT	upf0313 protein
E4185_00245	ENOG4105BZS	acriflavin resistance protein
E4185_00255	ENOG4105BZU	Histidine kinase
E4185_00260	ENOG4105D78	K07001 NTE family protein
E4185_00265	ENOG4105C8J	)-transporter
E4185_00280	ENOG4105UYK	outer membrane protein a
E4185_00295	ENOG4107R1I	NAD-dependent malic enzyme
E4185_00300	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4185_00310	ENOG4105RKX	Protein of unknown function (DUF2498)
E4185_00320	ENOG4105C2W	permease
E4185_00325	ENOG4108KMH	lipoate-protein ligase a
E4185_00330	ENOG4105BZG	amino acid carrier protein
E4185_00350	ENOG4105PTV	Nudix Hydrolase
E4185_00360	ENOG4105CDA	abc transporter atp-binding protein
E4185_00365	ENOG4105DRP	amino acid AbC transporter
E4185_00370	ENOG4105EZ7	amino acid ABC transporter
E4185_00390	ENOG4105CJ1	ABC, transporter
E4185_00395	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4185_00410	ENOG4106N3A	copper homeostasis protein cutc
E4185_00425	ENOG4105ERG	peptidase m48, ste24p
E4185_00430	ENOG4105DJH	phosphate
E4185_00440	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4185_00445	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
E4185_00455	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
E4185_00460	ENOG4105C26	Dehydrogenase
E4185_00470	ENOG4108IPJ	Membrane
E4185_00475	ENOG4106YYS	transcriptional regulatory protein
E4185_00480	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
E4185_00500	ENOG4105J12	Multidrug resistance protein mdtN
E4185_00525	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
E4185_00530	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
E4185_00540	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E4185_00545	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
E4185_00555	ENOG4105EXN	Sulfate transport protein CysZ
E4185_00560	ENOG4105EN6	Membrane
E4185_00570	ENOG4105EAQ	(twin-arginine translocation) pathway signal
E4185_00575	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
E4185_00605	ENOG4107T9C	Alpha amylase catalytic region
E4185_00650	ENOG4105BZU	Histidine kinase
E4185_00655	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E4185_00660	ENOG4105C9K	Endothelin-converting enzyme 1
E4185_00670	ENOG4105C5H	ABC transporter
E4185_00675	ENOG41068WN	
E4185_00680	ENOG4105DVH	amino acid
E4185_00685	ENOG4105C44	Serine transporter
E4185_00690	ENOG410642W	LysR family Transcriptional regulator
E4185_00700	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E4185_00705	ENOG4105C0B	DNA polymerase III (alpha subunit)
E4185_00710	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4185_00715	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4185_00720	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4185_00725	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E4185_00730	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4185_00735	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
E4185_00745	ENOG4105DZP	Membrane-associated zinc metalloprotease
E4185_00750	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E4185_00755	ENOG4105KNE	Phosphatidate cytidylyltransferase
E4185_00765	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E4185_00770	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E4185_00775	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E4185_00780	ENOG4105CE9	30S ribosomal protein S2
E4185_00785	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E4185_00790	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
E4185_00795	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E4185_00800	ENOG4108T8E	UPF0325 protein
E4185_00805	ENOG4105CI1	PTS System
E4185_00810	ENOG4107W52	maltose operon periplasmic protein
E4185_00815	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
E4185_00820	ENOG4105QDK	Flavodoxin
E4185_00825	ENOG4105DR9	pseudouridine synthase
E4185_00830	ENOG4105WP7	tRNA pseudouridine synthase C
E4185_00855	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
E4185_00860	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
E4185_00865	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E4185_00875	ENOG4105BZU	Histidine kinase
E4185_00880	ENOG4105EWT	decarboxylase family
E4185_00885	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
E4185_00890	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E4185_00900	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
E4185_00905	ENOG4105M08	Membrane
E4185_00915	ENOG4105ETT	transcriptional Regulator, LysR family
E4185_00920	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_00925	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E4185_00940	ENOG4105CJ2	(LipO)protein
E4185_00945	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
E4185_00950	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_00955	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_00960	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_00965	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_00970	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_00975	ENOG4105M85	Bola protein
E4185_00980	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E4185_00990	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E4185_01000	ENOG4105EYM	Major Facilitator superfamily
E4185_01005	ENOG4105DRB	nucleoside-specific channel-forming protein
E4185_01010	ENOG4108VPT	UPF0234 protein
E4185_01015	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E4185_01020	ENOG4107S0N	DJ-1 family
E4185_01025	ENOG4105CHH	sulfate transporter
E4185_01055	ENOG4105K89	arsenate reductase
E4185_01060	ENOG4105D6J	arsenicaL-resistance protein
E4185_01110	ENOG4105DH8	myo-inositol catabolism
E4185_01130	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E4185_01140	ENOG4107RUZ	Sss sodium solute transporter superfamily
E4185_01150	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
E4185_01160	ENOG4105C26	Dehydrogenase
E4185_01170	ENOG4105EQR	Transposase IS116 IS110 IS902
E4185_01180	ENOG4105J1P	transposase, IS3 IS911 family protein
E4185_01200	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
E4185_01205	ENOG4105C8I	hydrolase, family 38
E4185_01210	ENOG4105F2I	Transposase
E4185_01230	ENOG4105CMR	udp-glucose 4-epimerase
E4185_01235	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E4185_01240	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
E4185_01245	ENOG4108RMU	ferritin dps family protein
E4185_01270	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
E4185_01285	ENOG4107FW0	short-chain dehydrogenase reductase
E4185_01295	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E4185_01300	ENOG4108XDN	Transcriptional regulator
E4185_01305	ENOG4107SEY	Conserved Protein
E4185_01330	ENOG4105CQC	Prephenate dehydratase
E4185_01355	ENOG4107KGK	dmso reductase anchor subunit
E4185_01360	ENOG4105QAX	Iron-sulfur
E4185_01370	ENOG4105EQR	Transposase IS116 IS110 IS902
E4185_01405	ENOG4105MVE	transcriptional regulator
E4185_01415	ENOG4105G63	Type III effector Hrp-dependent
E4185_01420	ENOG4105FB2	class II Aldolase
E4185_01425	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
E4185_01430	ENOG4105EXW	epimerase dehydratase
E4185_01435	ENOG4105C6Z	Gluconate
E4185_01445	ENOG4108W2P	Methyl-accepting chemotaxis
E4185_01455	ENOG4105E1F	short-chain dehydrogenase reductase
E4185_01480	ENOG4105CTD	carboxy-peptidase
E4185_01500	ENOG4105XDF	Protein of unknown function (DUF1272)
E4185_01510	ENOG4105CFP	Peptidase U32
E4185_01515	ENOG4105N14	lysine exporter protein LysE YggA
E4185_01525	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4185_01550	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
E4185_01565	ENOG4106WHD	Tetrathionate reductase
E4185_01570	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E4185_01575	ENOG4105BZU	Histidine kinase
E4185_01580	ENOG4108ZXC	Two component transcriptional regulator, luxr family
E4185_01585	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
E4185_01600	ENOG4105C26	Dehydrogenase
E4185_01605	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E4185_01610	ENOG4105CDU	Replicative dna helicase
E4185_01615	ENOG4105CDU	Replicative dna helicase
E4185_01625	ENOG4105CGH	5'-nucleotidase
E4185_01645	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4185_01650	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4185_01665	ENOG4108YZY	peptidylprolyl cis-trans isomerase
E4185_01670	ENOG4105VKU	nucleicacid-binding protein
E4185_01685	ENOG4105DNZ	Alpha Beta Hydrolase
E4185_01695	ENOG4105YP7	UPF0270 protein
E4185_01700	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
E4185_01715	ENOG4108UKZ	OsmC family
E4185_01720	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
E4185_01730	ENOG4108MA4	Peptidase M66
E4185_01745	ENOG4105BZU	Histidine kinase
E4185_01750	ENOG4105D8G	Major Facilitator superfamily
E4185_01775	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
E4185_01780	ENOG41090JE	Utilization Protein
E4185_01790	ENOG4105EHG	Permease protein
E4185_01805	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
E4185_01815	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
E4185_01830	ENOG4105E4C	Lytic transglycosylase catalytic
E4185_01835	ENOG4105C5H	ABC transporter
E4185_01845	ENOG4105C7N	Xanthine uracil vitamin C permease
E4185_01850	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
E4185_01855	ENOG4108S0S	Nucleotidyl transferase
E4185_01860	ENOG4105EHM	Aminoglycoside phosphotransferase
E4185_01865	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
E4185_01875	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
E4185_01880	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E4185_01890	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E4185_01900	ENOG4105DEN	Luciferase family
E4185_01910	ENOG4105DWD	nucleoside recognition domain protein
E4185_01915	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4185_01920	ENOG4105K46	50S ribosomal protein l27
E4185_01925	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E4185_01930	ENOG4105EAH	synthase
E4185_01940	ENOG4105EPW	hflc protein
E4185_01945	ENOG4107QJR	hflk protein
E4185_01950	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E4185_01955	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E4185_01960	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E4185_01965	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E4185_01970	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E4185_01975	ENOG4105K8N	protein family UPF0079, ATPase
E4185_01980	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E4185_02000	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E4185_02005	ENOG4108UMI	ABC transporter, permease
E4185_02010	ENOG4105D01	(LipO)protein
E4185_02015	ENOG4105MDZ	Transcriptional activator rfaH
E4185_02020	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_02025	ENOG4105BZU	Histidine kinase
E4185_02050	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E4185_02055	ENOG4105BZU	Histidine kinase
E4185_02080	ENOG4105EXG	Transcriptional regulator
E4185_02090	ENOG4107QWK	SAICAR synthetase
E4185_02095	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4185_02100	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E4185_02105	ENOG4105RH4	Glycine cleavage system transcriptional repressor
E4185_02110	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4185_02115	ENOG4105XWI	UPF0304 protein
E4185_02120	ENOG4105PQ6	UPF0208 membrane protein
E4185_02125	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E4185_02130	ENOG4105C6K	Malic enzyme
E4185_02135	ENOG4108ZP8	Acetolactate synthase small subunit
E4185_02140	ENOG4105C7K	acetolactate synthase
E4185_02150	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E4185_02155	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
E4185_02165	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E4185_02175	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E4185_02180	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E4185_02195	ENOG4105DP9	ABC transporter
E4185_02200	ENOG4106SMU	thiamine transporter membrane protein
E4185_02215	ENOG4108IAB	Phoh family
E4185_02285	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
E4185_02295	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
E4185_02300	ENOG4105C1J	atp-dependent rna helicase
E4185_02310	ENOG4107YH7	Beta-lactamase (EC 3.5.2.6)
E4185_02320	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E4185_02325	ENOG4105DWY	Agmatine deiminase
E4185_02345	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4185_02350	ENOG4108MJ3	acetyltransferase
E4185_02365	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E4185_02380	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
E4185_02395	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
E4185_02405	ENOG4108IQE	Amp-dependent synthetase and ligase
E4185_02430	ENOG4107SQD	Transcriptional regulator, GntR family
E4185_02445	ENOG4105C8J	)-transporter
E4185_02450	ENOG4105C8J	)-transporter
E4185_02465	ENOG4108K4B	hydrolase
E4185_02480	ENOG4105EW9	transcriptional regulator AsnC family
E4185_02495	ENOG4105K56	Transcriptional regulator
E4185_02500	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
E4185_02515	ENOG4105E0X	reductase
E4185_02525	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
E4185_02530	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
E4185_02535	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E4185_02540	ENOG4105DSB	aldose 1-epimerase
E4185_02545	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
E4185_02620	ENOG4105UFD	tol-pal system protein YbgF
E4185_02625	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E4185_02630	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E4185_02640	ENOG4105M8F	Biopolymer transport protein exbD tolR
E4185_02645	ENOG4105E02	MotA TolQ exbB proton channel
E4185_02650	ENOG4107YD3	Thioesterase
E4185_02655	ENOG4105KJB	cyd operon protein YbgE
E4185_02665	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4185_02670	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4185_02675	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E4185_02680	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E4185_02685	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E4185_02690	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
E4185_02705	ENOG4105E39	Enoyl-CoA hydratase
E4185_02710	ENOG4106WH9	Protein of unknown function (DUF2753)
E4185_02715	ENOG4105EQK	-acetyltransferase
E4185_02725	ENOG4107QSI	ABC, transporter
E4185_02735	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
E4185_02740	ENOG4108QYW	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity)
E4185_02755	ENOG4105C1J	atp-dependent rna helicase
E4185_02760	ENOG4105EUZ	Beta-lactamase domain protein
E4185_02770	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
E4185_02800	ENOG4105CGF	Aromatic amino acid aminotransferase
E4185_02815	ENOG41076CZ	activating enzyme
E4185_02820	ENOG4105G0K	glycine radical enzyme YjjI family
E4185_02850	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_02855	ENOG4108M1A	Chitin-binding protein
E4185_02865	ENOG4107R11	Transcriptional regulator
E4185_02870	ENOG4108IJ6	ABC transporter
E4185_02875	ENOG4105ECW	sulfate abc transporter
E4185_02890	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
E4185_02925	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
E4185_02930	ENOG4105D3G	Pseudouridine synthase
E4185_02940	ENOG4105BZU	Histidine kinase
E4185_02950	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E4185_02955	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E4185_02965	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
E4185_02970	ENOG4108IJ0	Aspartate ammonia-lyase
E4185_02975	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
E4185_02980	ENOG4105D9M	gamma-glutamylcysteine synthetase
E4185_02990	ENOG4105W39	Membrane
E4185_02995	ENOG4105DQ4	alcohol dehydrogenase
E4185_03025	ENOG4105DP0	ferredoxin-NADP reductase
E4185_03030	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E4185_03035	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E4185_03040	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E4185_03045	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
E4185_03060	ENOG4107YB6	acetyltransferase, (GNAT) family
E4185_03070	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E4185_03075	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E4185_03080	ENOG4106TD9	Diguanylate cyclase
E4185_03085	ENOG4105VNT	transposase (IS4 family) protein
E4185_03090	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
E4185_03100	ENOG4108YZA	Nitrogen regulatory protein pii
E4185_03105	ENOG4105C4K	Nad synthetase
E4185_03135	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E4185_03140	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
E4185_03145	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E4185_03150	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E4185_03155	ENOG4105DTN	riboflavin biosynthesis protein ribF
E4185_03160	ENOG4105CJR	Integral membrane protein (MviN
E4185_03165	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E4185_03170	ENOG41080HT	Transcriptional regulator, arsr family
E4185_03175	ENOG41063Z6	transcriptional regulator, lysR family
E4185_03185	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E4185_03190	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E4185_03195	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E4185_03200	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
E4185_03205	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E4185_03220	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E4185_03225	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E4185_03230	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E4185_03235	ENOG4105K5M	30s ribosomal protein S16
E4185_03240	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4185_03245	ENOG4106KVJ	cytochrome C assembly protein
E4185_03250	ENOG4108JU6	CBS domain protein
E4185_03260	ENOG4108EGH	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E4185_03265	ENOG4108UV7	flagellar protein motX
E4185_03270	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E4185_03275	ENOG4105DMR	ABC, transporter
E4185_03280	ENOG4105GBT	ABC transporter
E4185_03285	ENOG4106PMH	Extracellular solute-binding protein family 3
E4185_03290	ENOG4105E5Z	arginine transporter ATP-binding subunit
E4185_03295	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
E4185_03300	ENOG4105EZR	dyp-type peroxidase family protein
E4185_03305	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4185_03315	ENOG4107QKW	extracellular solute-binding protein family 1
E4185_03320	ENOG4108YZA	Nitrogen regulatory protein pii
E4185_03335	ENOG4105D9N	nucleoside
E4185_03340	ENOG4105HEI	LysR family (Transcriptional regulator
E4185_03355	ENOG4105BZW	Glycerate kinase
E4185_03360	ENOG4107QQ0	gntp family
E4185_03365	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
E4185_03370	ENOG4105XTV	UPF0231 protein
E4185_03390	ENOG4105VZ9	UPF0235 protein
E4185_03395	ENOG4108VIA	integral membrane protein
E4185_03400	ENOG4105II7	pyrroline-5-carboxylate reductase
E4185_03405	ENOG4105DFA	alanine racemase domain protein
E4185_03410	ENOG4105CZX	twitching motility protein
E4185_03415	ENOG4105CZX	twitching motility protein
E4185_03420	ENOG4105D1Q	UPF0246 protein
E4185_03425	ENOG4105C1J	atp-dependent rna helicase
E4185_03430	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
E4185_03435	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
E4185_03450	ENOG4105MYN	Zinc uptake regulation protein
E4185_03455	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E4185_03470	ENOG4105K70	DNA-binding protein
E4185_03475	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
E4185_03485	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
E4185_03500	ENOG4105EAC	phosphoserine phosphatase
E4185_03510	ENOG4108NST	exported protein
E4185_03525	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E4185_03530	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
E4185_03535	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E4185_03545	ENOG4105D9N	nucleoside
E4185_03550	ENOG4105EYA	deoxyribonuclease
E4185_03570	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4185_03575	ENOG4105BZU	Histidine kinase
E4185_03585	ENOG4105F2I	Transposase
E4185_03595	ENOG4105VTR	Integrase
E4185_03600	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4185_03610	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E4185_03700	ENOG4105ED4	portal protein
E4185_03845	ENOG4108K5H	permease YjgP YjgQ family protein
E4185_03850	ENOG4108M8S	permease YjgP YjgQ family protein
E4185_03855	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4185_03860	ENOG4105MYG	DNA polymerase iii, chi subunit
E4185_03875	ENOG4106W5V	Membrane
E4185_03880	ENOG41061WM	D-Alanyl-D-Alanine
E4185_03915	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
E4185_03920	ENOG4105CFH	Aspartokinase
E4185_03925	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E4185_03930	ENOG4105Y3E	Modulates RecA activity (By similarity)
E4185_03935	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E4185_03940	ENOG4107TH8	cina domain protein
E4185_03950	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E4185_03970	ENOG4105R2J	Conserved Protein
E4185_03980	ENOG4105DR5	peptidase
E4185_04000	ENOG4105NXV	High-affinity zinc uptake system protein
E4185_04005	ENOG4105FDK	ABC transporter
E4185_04010	ENOG4105FAV	ABC, transporter
E4185_04015	ENOG4105ETT	transcriptional Regulator, LysR family
E4185_04025	ENOG4108RG0	uracil-dna glycosylase
E4185_04035	ENOG41082IR	Excinuclease ABC C subunit domain protein
E4185_04050	ENOG41087YS	Phage shock protein A
E4185_04055	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
E4185_04075	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4185_04085	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4185_04130	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4185_04135	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4185_04150	ENOG4105IPS	esterase
E4185_04155	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
E4185_04160	ENOG4108SX3	cytoplasmic protein
E4185_04165	ENOG41087AY	ADP-Ribose pyrophosphatase
E4185_04170	ENOG4105DFG	type I secretion outer membrane protein
E4185_04175	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
E4185_04180	ENOG4105D1S	lipid A biosynthesis
E4185_04185	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
E4185_04190	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
E4185_04195	ENOG4105VJY	transcriptional regulator
E4185_04200	ENOG4105NNS	Autoinducer synthesis protein
E4185_04210	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
E4185_04215	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
E4185_04220	ENOG4105CTS	PTS system mannitol-specific
E4185_04225	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
E4185_04230	ENOG4105E61	Mannitol repressor protein
E4185_04255	ENOG4108UPT	UPF0178 protein
E4185_04270	ENOG4105D9N	nucleoside
E4185_04275	ENOG4105C1J	atp-dependent rna helicase
E4185_04300	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
E4185_04310	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
E4185_04315	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
E4185_04320	ENOG4108IPT	Naphthoate synthase
E4185_04325	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
E4185_04335	ENOG4107MM9	BNR Asp-box repeat-containing protein
E4185_04340	ENOG4108UB4	uncharacterized protein ygjQ
E4185_04345	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E4185_04355	ENOG4107IFA	Lipase (EC 3.1.1.3)
E4185_04385	ENOG4108IQK	o-acetylhomoserine
E4185_04395	ENOG4108I6A	alcohol dehydrogenase
E4185_04410	ENOG4105EMU	Dehydrogenase
E4185_04445	ENOG4105E0M	Sulfatase
E4185_04450	ENOG4105SYT	Methylenetetrahydrofolate reductase
E4185_04470	ENOG4105EIF	outer membrane protein W
E4185_04475	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E4185_04480	ENOG41086KC	Transcriptional regulator
E4185_04485	ENOG4108UUM	single-stranded DNA-binding protein
E4185_04505	ENOG4105VEQ	Cold shock protein
E4185_04510	ENOG4105E0F	Histidine kinase
E4185_04525	ENOG4108NVR	Methyl-accepting chemotaxis
E4185_04535	ENOG4105BZU	Histidine kinase
E4185_04540	ENOG4108YZA	Nitrogen regulatory protein pii
E4185_04555	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
E4185_04575	ENOG4107QKA	exodeoxyribonuclease V beta
E4185_04580	ENOG4105DSY	exodeoxyribonuclease V, gamma
E4185_04585	ENOG4108VBZ	doxx family
E4185_04590	ENOG4105C2I	pirin domain protein
E4185_04600	ENOG4105CWB	LysR family transcriptional Regulator
E4185_04625	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
E4185_04635	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4185_04645	ENOG4105BZU	Histidine kinase
E4185_04660	ENOG4105CF7	AraC family transcriptional regulator
E4185_04665	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
E4185_04670	ENOG4105CH6	catalase
E4185_04695	ENOG4105IPI	Membrane
E4185_04710	ENOG4105DWY	Agmatine deiminase
E4185_04720	ENOG4105DWY	Agmatine deiminase
E4185_04725	ENOG4105ETT	transcriptional Regulator, LysR family
E4185_04730	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
E4185_04740	ENOG4108UTZ	Dihydroxyacetone kinase
E4185_04745	ENOG4105CMT	Dihydroxyacetone kinase
E4185_04750	ENOG4105C7N	Xanthine uracil vitamin C permease
E4185_04755	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
E4185_04790	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
E4185_04795	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4185_04800	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E4185_04805	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E4185_04810	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E4185_04815	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
E4185_04830	ENOG4105KME	endoribonuclease L-psp
E4185_04835	ENOG4105WWK	YheO domain protein
E4185_04840	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4185_04845	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4185_04850	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E4185_04855	ENOG4108VZM	50s ribosomal protein L10
E4185_04860	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E4185_04865	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E4185_04870	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E4185_04875	ENOG4105PM1	preprotein translocase subunit SecE
E4185_04885	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4185_04900	ENOG4105CS9	pantothenic acid kinase
E4185_04905	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E4185_04910	ENOG4105D4A	Cell wall formation (By similarity)
E4185_04915	ENOG4107ZYR	domain protein
E4185_04925	ENOG4108IYH	Dna topoisomerase
E4185_04930	ENOG4105CUW	cytochrome C-TYPE protein
E4185_04950	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4185_04965	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
E4185_04980	ENOG4108UQ5	membrane protein YcdZ
E4185_04985	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4185_04995	ENOG4107WP9	Histidine kinase
E4185_05010	ENOG410642E	Short chain dehydrogenase
E4185_05015	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4185_05030	ENOG4108VVK	transcriptional Regulator, AsnC
E4185_05035	ENOG4105CU9	asparagine synthetase A
E4185_05040	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4185_05045	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E4185_05050	ENOG4105C34	Pseudouridine synthase
E4185_05055	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4185_05060	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4185_05065	ENOG4107R6U	sodium dicarboxylate symporter
E4185_05070	ENOG4105CEM	UPF0597 protein
E4185_05075	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E4185_05080	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E4185_05085	ENOG4108I6A	alcohol dehydrogenase
E4185_05090	ENOG4105CF7	AraC family transcriptional regulator
E4185_05095	ENOG4105QNF	Outer membrane lipoprotein
E4185_05100	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_05110	ENOG4105DJ4	phosphatidylserine decarboxylase
E4185_05125	ENOG4105CXT	aspartate transcarbamylase
E4185_05130	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
E4185_05135	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
E4185_05140	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4185_05145	ENOG4105DBV	ornithine carbamoyltransferase
E4185_05150	ENOG4105C5B	carbamate kinase
E4185_05170	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_05175	ENOG4108HWV	)-transporter
E4185_05190	ENOG4105CNT	hydrolase family 2
E4185_05195	ENOG41060NJ	transcriptional regulator
E4185_05205	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
E4185_05210	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E4185_05215	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4185_05220	ENOG4105CPC	Aldo Keto reductase
E4185_05225	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E4185_05230	ENOG4108NIX	Factor ChrR
E4185_05235	ENOG4105K6V	RNA polymerase
E4185_05245	ENOG4105C75	arginyL-tRNA synthetase
E4185_05255	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E4185_05260	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E4185_05280	ENOG4105D0S	secretion protein (HlyD
E4185_05285	ENOG4105CJ1	ABC, transporter
E4185_05290	ENOG4107QWP	ABC-2 type transporter
E4185_05295	ENOG4107QWP	ABC-2 type transporter
E4185_05300	ENOG4107QZF	nitrite reductase NADPH large subunit
E4185_05305	ENOG4105WZK	nitrite reductase NADPH small subunit
E4185_05310	ENOG4107V9H	nitrite transporter
E4185_05315	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E4185_05320	ENOG4105CJW	magnesium transporter
E4185_05325	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E4185_05330	ENOG4105EX9	Membrane
E4185_05340	ENOG4105CNG	UPF0061 protein
E4185_05345	ENOG4105N7H	Cytochrome
E4185_05350	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4185_05355	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4185_05360	ENOG4108VUY	thioesterase Superfamily protein
E4185_05380	ENOG4108RPX	mosc domain containing protein
E4185_05385	ENOG4105D38	putrescine abc transporter
E4185_05390	ENOG4105F38	ABC transporter, permease
E4185_05395	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4185_05400	ENOG4108HM4	ABC transporter
E4185_05410	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E4185_05415	ENOG4105CFQ	glutamine synthetase
E4185_05420	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4185_05435	ENOG4108RH0	Crea protein
E4185_05440	ENOG4105C5I	Dehydrogenase
E4185_05445	ENOG4105R8A	Heat shock protein
E4185_05460	ENOG4107R28	alpha amylase, catalytic region
E4185_05475	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
E4185_05480	ENOG4107EXC	regulatoR
E4185_05485	ENOG4105JJR	Histidine kinase
E4185_05495	ENOG4105C6K	Malic enzyme
E4185_05500	ENOG4105CGD	Nad-dependent epimerase dehydratase
E4185_05505	ENOG4105VFB	Binds the 23S rRNA (By similarity)
E4185_05510	ENOG4105C25	Primosomal protein n'
E4185_05515	ENOG4105UYK	outer membrane protein a
E4185_05525	ENOG4105C7B	Threonine dehydratase
E4185_05530	ENOG4105C01	Dihydroxy-acid dehydratase
E4185_05535	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E4185_05540	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
E4185_05555	ENOG4105C0P	Mg chelatase subunit ChlI
E4185_05560	ENOG4106HNH	Acyl-transferase
E4185_05565	ENOG4106HNH	Acyl-transferase
E4185_05570	ENOG4105EWC	Purine nucleoside phosphorylase
E4185_05580	ENOG4108RWI	nicotinamidase
E4185_05585	ENOG4107RH7	Nicotinate phosphoribosyltransferase
E4185_05590	ENOG4105EHI	Phosphonate ABC transporter, periplasmic
E4185_05595	ENOG4108VA1	ABC transporter
E4185_05600	ENOG4105S7S	phosphonate abc transporter
E4185_05605	ENOG4108Z33	Thiol disulfide Interchange Protein
E4185_05610	ENOG4105E27	serine threonine protein kinase
E4185_05620	ENOG4105PC1	Conserved Protein
E4185_05640	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E4185_05645	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
E4185_05650	ENOG4105DSJ	YicC domain protein
E4185_05660	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E4185_05665	ENOG4105XA0	heptosyltransferase ii
E4185_05670	ENOG4106WTF	Glycosyl transferase, family 2
E4185_05675	ENOG4105M5K	heptosyltransferase
E4185_05680	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E4185_05685	ENOG4108MJ5	VirK protein
E4185_05690	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E4185_05700	ENOG4105W0E	50S ribosomal protein L33
E4185_05705	ENOG4105KDC	50s ribosomal protein l28
E4185_05715	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E4185_05725	ENOG4105F2I	Transposase
E4185_05735	ENOG4108IJF	Heavy metal efflux pump, CzcA
E4185_05745	ENOG4105F2I	Transposase
E4185_05750	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E4185_05760	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
E4185_05765	ENOG4105D64	Mechanosensitive ion channel
E4185_05775	ENOG4107QP8	phosphohexose isomerase
E4185_05780	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E4185_05785	ENOG4105EMY	transcriptional regulator
E4185_05795	ENOG4105CD5	CoA-binding domain protein
E4185_05825	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E4185_05830	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E4185_05835	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E4185_05840	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E4185_05845	ENOG4105FCD	Major Facilitator
E4185_05850	ENOG4105DY9	regulatoR
E4185_05855	ENOG4108HRK	Histidine kinase
E4185_05865	ENOG4105EU0	Major facilitator Superfamily
E4185_05870	ENOG4105CBX	hi0933 family
E4185_05875	ENOG41090A1	ferritin
E4185_05880	ENOG4105BZU	Histidine kinase
E4185_05885	ENOG4105RKW	reductase (By
E4185_05890	ENOG4108M6U	Universal stress protein A
E4185_05920	ENOG4105EMK	carboxylate amino acid amine transporter
E4185_05930	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
E4185_05935	ENOG4105DKP	glycosyl transferase, family 9
E4185_05950	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E4185_05955	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4185_05960	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
E4185_05965	ENOG4108EUD	Lysophospholipase
E4185_05975	ENOG4105DQF	Hydrolase
E4185_06005	ENOG4105Y7M	Transcriptional regulator, TetR family
E4185_06010	ENOG410624X	efflux transporter, rnd family, mfp subunit
E4185_06015	ENOG4105BZS	acriflavin resistance protein
E4185_06020	ENOG4105BZU	Histidine kinase
E4185_06025	ENOG4105DC8	reductase
E4185_06035	ENOG4105CB2	alcohol dehydrogenase
E4185_06040	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
E4185_06045	ENOG4105KVH	Transcriptional regulator
E4185_06055	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E4185_06060	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E4185_06065	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
E4185_06070	ENOG4105C08	Histidine kinase
E4185_06075	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
E4185_06080	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4185_06100	ENOG4108ZNX	Heat shock protein
E4185_06105	ENOG4108ZNX	Heat shock protein
E4185_06110	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
E4185_06115	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4185_06120	ENOG4105D29	Helix-turn-helix type 11 domain protein
E4185_06130	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4185_06135	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4185_06140	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E4185_06145	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E4185_06150	ENOG4105EAB	amino acid AbC transporter
E4185_06155	ENOG4105E5Q	amino acid AbC transporter
E4185_06160	ENOG4105CDA	abc transporter atp-binding protein
E4185_06165	ENOG4105VG0	50S ribosomal protein l34
E4185_06170	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E4185_06175	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E4185_06180	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E4185_06185	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E4185_06190	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
E4185_06195	ENOG4105J76	Periplasmic binding protein
E4185_06200	ENOG4105E0A	ABC, transporter
E4185_06205	ENOG4105IBP	Cyclic peptide transporter
E4185_06210	ENOG4105E0K	tonB-dependent siderophore receptor
E4185_06215	ENOG4105QTB	Flavodoxin
E4185_06220	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E4185_06225	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E4185_06230	ENOG4107QJE	Chromosome Partitioning Protein
E4185_06235	ENOG4105FA0	parb-like partition protein
E4185_06245	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
E4185_06250	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4185_06255	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4185_06260	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4185_06265	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E4185_06270	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E4185_06275	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E4185_06280	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E4185_06285	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E4185_06290	ENOG4105CT7	inner membrane cred family protein
E4185_06300	ENOG4105EB3	Histidine kinase
E4185_06305	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E4185_06310	ENOG410804X	Transcriptional regulator
E4185_06315	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E4185_06325	ENOG4105F2I	Transposase
E4185_06335	ENOG4105VJY	transcriptional regulator
E4185_06355	ENOG4109015	Biopolymer transport protein exbD tolR
E4185_06360	ENOG410822N	TonB family
E4185_06395	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
E4185_06400	ENOG4105DZC	cytosine deaminase
E4185_06405	ENOG4105WMR	Protein CrcB homolog
E4185_06410	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E4185_06415	ENOG4105JC1	sterol-binding domain protein
E4185_06420	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
E4185_06425	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E4185_06430	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
E4185_06435	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E4185_06440	ENOG4105F8V	Hydrolase, tatD family
E4185_06445	ENOG4105D52	delta-aminolevulinic acid dehydratase
E4185_06450	ENOG4105DGW	oligopeptidase A
E4185_06455	ENOG4105BZU	Histidine kinase
E4185_06460	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
E4185_06475	ENOG4105C9X	ppx gppa phosphatase
E4185_06480	ENOG4105C1J	atp-dependent rna helicase
E4185_06490	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E4185_06500	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
E4185_06505	ENOG4107QK7	reductase
E4185_06510	ENOG4105W0Z	cytoplasmic protein
E4185_06525	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E4185_06540	ENOG4108IV0	ABC, transporter
E4185_06545	ENOG4105C0Z	ABC transporter
E4185_06550	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
E4185_06555	ENOG4105C32	Amino acid ABC transporter (Permease)
E4185_06560	ENOG4105CP9	extracellular ligand-binding receptor
E4185_06565	ENOG4105ETE	Transcriptional regulator (LacI family
E4185_06570	ENOG4108JUA	Transcriptional regulator
E4185_06575	ENOG4105CNW	domain protein
E4185_06580	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
E4185_06590	ENOG4105HEE	Binding Domain protein
E4185_06605	ENOG4105CIC	tryptophan-specific transport protein
E4185_06620	ENOG4105F2I	Transposase
E4185_06645	ENOG41090VV	Protein of unknown function (DUF2846)
E4185_06650	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E4185_06655	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
E4185_06660	ENOG4108R3E	Dna-3-methyladenine glycosylase i
E4185_06690	ENOG4108ZG0	Ompa motb domain protein
E4185_06695	ENOG4105M4H	endoribonuclease L-psp
E4185_06700	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
E4185_06720	ENOG4105E0F	Histidine kinase
E4185_06730	ENOG4105CHU	acetyl-coa acetyltransferase
E4185_06735	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E4185_06740	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E4185_06745	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
E4185_06750	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E4185_06755	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E4185_06760	ENOG4108RR8	protoporphyrinogen oxidase
E4185_06790	ENOG4105CUZ	uba thif-type nad fad binding protein
E4185_06795	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
E4185_06800	ENOG4105C9B	Cysteine desulfurase
E4185_06805	ENOG4105C4R	Atp-dependent dna helicase
E4185_06810	ENOG4105BZU	Histidine kinase
E4185_06820	ENOG4105CPQ	Dehydrogenase
E4185_06825	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4185_06830	ENOG41062JF	Transcriptional regulator
E4185_06835	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
E4185_06840	ENOG4105E2K	Glycosyl transferase (Group 1
E4185_06845	ENOG4105PF3	O-Antigen polymerase
E4185_06860	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
E4185_06875	ENOG4105X6C	Flagellar basal body-associated protein FliL
E4185_06880	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
E4185_06885	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E4185_06895	ENOG4105E55	glycerol-3-phosphate acyltransferase
E4185_06900	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E4185_06915	ENOG4107R73	Mate efflux family protein
E4185_06920	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E4185_06925	ENOG4105E0F	Histidine kinase
E4185_06930	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E4185_06940	ENOG4105D7W	serine acetyltransferase
E4185_06950	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
E4185_06955	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
E4185_06965	ENOG4105C2M	dna polymerase I
E4185_06970	ENOG4108Z0R	Transferase
E4185_07010	ENOG4105CQ4	Transcriptional regulator
E4185_07015	ENOG4105CNT	hydrolase family 2
E4185_07020	ENOG4105FK9	beta-D-galactosidase beta subunit
E4185_07025	ENOG4105E5D	amino acid
E4185_07030	ENOG4108Y51	tRNA-binding protein
E4185_07035	ENOG4105E5D	amino acid
E4185_07040	ENOG4105DHU	Bile acid
E4185_07045	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
E4185_07065	ENOG4105CC0	LysR family Transcriptional regulator
E4185_07080	ENOG4105UIB	(ABC) transporter
E4185_07085	ENOG4108JQ9	ABC transporter
E4185_07090	ENOG4105DIH	basic membrane
E4185_07095	ENOG4105C4R	Atp-dependent dna helicase
E4185_07130	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4185_07140	ENOG41061EV	selenium-binding protein YdfZ
E4185_07160	ENOG4108YH8	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
E4185_07165	ENOG4105CUC	YeeE YedE family protein
E4185_07170	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
E4185_07175	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4185_07180	ENOG4105FR1	rard protein
E4185_07190	ENOG4105C26	Dehydrogenase
E4185_07195	ENOG4108JCI	Transcriptional regulator
E4185_07205	ENOG4105C26	Dehydrogenase
E4185_07210	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4185_07215	ENOG4107R11	Transcriptional regulator
E4185_07220	ENOG4108TFM	Kinase, PfkB family
E4185_07240	ENOG4105CGY	Dna recombination protein
E4185_07245	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E4185_07250	ENOG4105C1A	potassium transporter peripheral membrane
E4185_07255	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E4185_07260	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E4185_07265	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E4185_07275	ENOG4105C79	DNA protecting protein DprA
E4185_07280	ENOG4108RPN	Protein smg homolog
E4185_07285	ENOG4108WI1	Dna topoisomerase
E4185_07290	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4185_07295	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
E4185_07300	ENOG4105E2X	shikimate dehydrogenase
E4185_07305	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E4185_07310	ENOG4106RE7	Cytochrome
E4185_07315	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
E4185_07320	ENOG4105XCT	Protein of unknown function (DUF2489)
E4185_07325	ENOG4105D4P	Coproporphyrinogen iii oxidase
E4185_07330	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4185_07335	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4185_07340	ENOG4105CUX	Signal transduction histidine kinase
E4185_07350	ENOG4105C5F	glutamine synthetase
E4185_07355	ENOG4105CI3	gtp-binding protein typa
E4185_07360	ENOG4107S2Z	UPF0761 membrane protein
E4185_07365	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E4185_07375	ENOG4105SUU	thioesterase domain
E4185_07385	ENOG4105CB5	ATP-dependent DNA helicase recG
E4185_07395	ENOG4105C6Z	Gluconate
E4185_07400	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
E4185_07405	ENOG4105C01	Dihydroxy-acid dehydratase
E4185_07410	ENOG4108UHU	Aldolase
E4185_07415	ENOG4105DIQ	Transcriptional regulator
E4185_07425	ENOG41063SB	peptidase
E4185_07430	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E4185_07435	ENOG4107YZP	Rhodanese domain protein
E4185_07440	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E4185_07445	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E4185_07450	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
E4185_07455	ENOG4105MJ2	Competence protein
E4185_07460	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
E4185_07475	ENOG4105BZM	domain protein
E4185_07480	ENOG4108RRZ	Transcription elongation factor GreB
E4185_07490	ENOG4105E0F	Histidine kinase
E4185_07500	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E4185_07505	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E4185_07510	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E4185_07515	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E4185_07520	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4185_07525	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E4185_07530	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E4185_07535	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E4185_07540	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E4185_07545	ENOG41083MP	50s ribosomal protein l29
E4185_07550	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E4185_07555	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E4185_07560	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E4185_07565	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4185_07570	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E4185_07575	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E4185_07580	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E4185_07585	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E4185_07590	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E4185_07595	ENOG4105VPB	50S ribosomal protein L30
E4185_07600	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E4185_07605	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E4185_07610	ENOG41067V7	50S ribosomal protein L36
E4185_07615	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4185_07620	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E4185_07625	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E4185_07630	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4185_07635	ENOG4108ZT0	50S ribosomal protein l17
E4185_07690	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
E4185_07705	ENOG4105CUG	Oligopeptidase b
E4185_07730	ENOG4107FS9	Membrane
E4185_07745	ENOG4105JQN	Transcriptional regulator
E4185_07760	ENOG4105VVZ	metal-binding protein
E4185_07765	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
E4185_07785	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4185_07790	ENOG4107RZC	phospholipase d
E4185_07800	ENOG4105EJ2	Transcriptional regulator
E4185_07805	ENOG4108Y73	Membrane
E4185_07820	ENOG4106H78	methyltransferase
E4185_07825	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E4185_07830	ENOG4105CAK	Cell division ATP-binding protein ftsE
E4185_07835	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
E4185_07840	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4185_07845	ENOG41077A9	carbonic anhydrase
E4185_07850	ENOG4105CZE	histidine utilization repressor
E4185_07855	ENOG4105CI2	imidazolone-5-propionate hydrolase
E4185_07860	ENOG41088SP	formiminoglutamate hydrolase
E4185_07865	ENOG4105CGP	Urocanate hydratase
E4185_07870	ENOG4105C84	Histidine ammonia-lyase
E4185_07875	ENOG4105EWV	Sodium calcium exchanger membrane region
E4185_07880	ENOG4105CXC	rtn protein
E4185_07885	ENOG41062P1	Diguanylate cyclase phosphodiesterase
E4185_07915	ENOG4105GVR	general secretion pathway protein D
E4185_07930	ENOG4107QHF	type ii secretion system protein e
E4185_07935	ENOG4105D7Q	type ii secretion system
E4185_07950	ENOG4108VAU	general secretion pathway protein G
E4185_07985	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E4185_07990	ENOG4105VQ7	Rod shape-determining protein MreD
E4185_07995	ENOG4108Z03	MAF-like protein
E4185_08000	ENOG4105C03	ribonuclease
E4185_08005	ENOG4105QD6	exported protein
E4185_08015	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E4185_08030	ENOG4105CSH	Transporter
E4185_08040	ENOG4105CGZ	zinc metallopeptidase
E4185_08050	ENOG4105KNA	-acetyltransferase
E4185_08060	ENOG4105EEQ	Na H antiporter
E4185_08065	ENOG4105C3R	Methionine synthase
E4185_08070	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
E4185_08080	ENOG4105ETX	regulatoR
E4185_08095	ENOG4108MR7	Arylsulfotransferase
E4185_08100	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
E4185_08105	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
E4185_08110	ENOG4105D06	uba thif-type nad fad binding protein
E4185_08120	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
E4185_08125	ENOG4105D41	biosynthesis protein thiH
E4185_08130	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E4185_08145	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
E4185_08150	ENOG4105BZU	Histidine kinase
E4185_08155	ENOG4108TPP	exopolysaccharide synthesis
E4185_08170	ENOG4105N0V	mono-oxygenase ydhR
E4185_08195	ENOG4108Z7F	N-acetyltransferase
E4185_08200	ENOG4105FCK	Membrane
E4185_08205	ENOG4105CBT	Fructose-1,6-bisphosphatase
E4185_08210	ENOG4105KRS	Proteinase inhibitor
E4185_08215	ENOG410601J	HemY protein
E4185_08220	ENOG4105ECF	c-methyltransferase
E4185_08225	ENOG41076E6	Uroporphyrinogen-III Synthase
E4185_08235	ENOG4107T0K	Adenylate cyclase
E4185_08240	ENOG4106CJB	Phospholipase Carboxylesterase
E4185_08245	ENOG4105XQ6	frataxin-like protein
E4185_08255	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E4185_08260	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E4185_08270	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4185_08275	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
E4185_08285	ENOG4108Z86	Glutamine amidotransferase
E4185_08290	ENOG410667J	hydrolase
E4185_08300	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
E4185_08305	ENOG4108I62	cina-like protein
E4185_08315	ENOG4105CVG	Homoserine O-transsuccinylase
E4185_08325	ENOG4108YXU	transcriptional regulator AsnC family
E4185_08335	ENOG4105DKK	Benzoate
E4185_08340	ENOG4108JCI	Transcriptional regulator
E4185_08370	ENOG41090HJ	UPF0265 protein
E4185_08380	ENOG4105N42	UPF0307 protein
E4185_08390	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E4185_08395	ENOG4105VFK	BolA family
E4185_08405	ENOG4105E3I	toluene tolerance
E4185_08410	ENOG4107PE3	Mammalian cell entry related domain protein
E4185_08415	ENOG4105CY3	ABC transporter, permease
E4185_08420	ENOG4105DHJ	ABC, transporter
E4185_08425	ENOG4105C2X	Arabinose 5-phosphate isomerase
E4185_08435	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
E4185_08440	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
E4185_08445	ENOG4108IUZ	ABC transporter
E4185_08450	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4185_08455	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
E4185_08460	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
E4185_08465	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E4185_08470	ENOG41080Z8	PHOSPHOCARRIER protein
E4185_08480	ENOG4105C0H	protease
E4185_08485	ENOG4105C0H	protease
E4185_08495	ENOG4105D6Z	AFG1 family ATPase
E4185_08500	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E4185_08505	ENOG4108UJD	30S ribosomal protein S9
E4185_08510	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E4185_08520	ENOG4105EIX	cytochrome c1
E4185_08525	ENOG4107MKT	Stringent starvation protein a
E4185_08530	ENOG4105KB2	stringent starvation protein b
E4185_08535	ENOG4105W4M	Transport-associated protein
E4185_08545	ENOG41082RQ	UPF0102 protein
E4185_08550	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
E4185_08555	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E4185_08565	ENOG4108V6E	Cell division protein mraZ
E4185_08570	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E4185_08575	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E4185_08585	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E4185_08590	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
E4185_08595	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E4185_08605	ENOG4105CNI	cell division protein FtsW
E4185_08610	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E4185_08615	ENOG4105DFU	Cell wall formation (By similarity)
E4185_08620	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
E4185_08625	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E4185_08630	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E4185_08635	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4185_08645	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E4185_08655	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
E4185_08660	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
E4185_08670	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
E4185_08675	ENOG4105D7Q	type ii secretion system
E4185_08680	ENOG4107QHF	type ii secretion system protein e
E4185_08695	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
E4185_08710	ENOG41073TP	transcriptional regulator
E4185_08715	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
E4185_08720	ENOG4107QSN	dihydrolipoamide acetyltransferase
E4185_08725	ENOG4107QN2	dihydrolipoyl dehydrogenase
E4185_08730	ENOG4105BZU	Histidine kinase
E4185_08745	ENOG41069D7	Methyl-accepting chemotaxis
E4185_08755	ENOG4107QIJ	Aconitate hydratase 2
E4185_08760	ENOG4105BZU	Histidine kinase
E4185_08765	ENOG4108MGI	Transcriptional regulator
E4185_08770	ENOG4105E82	cytochrome subunit of dehydrogenase
E4185_08780	ENOG4105CKI	cobalamin synthesis protein
E4185_08795	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4185_08800	ENOG4107ZVW	dihydroneopterin aldolase
E4185_08805	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E4185_08910	ENOG4105UYK	outer membrane protein a
E4185_08935	ENOG4107AQZ	Membrane
E4185_08945	ENOG4108UW5	maltose o-acetyltransferase
E4185_08950	ENOG4105CG3	alpha amylase, catalytic region
E4185_08955	ENOG4105C5Y	PTS System
E4185_08960	ENOG4105D4X	repressor
E4185_08970	ENOG4105CK1	PTS System
E4185_08975	ENOG4105VZJ	PTS System
E4185_08980	ENOG4105CK1	PTS System
E4185_08985	ENOG4105CS2	ec 3.2.1.21
E4185_08990	ENOG4105VCP	PTS System
E4185_08995	ENOG4105DKQ	ROK family
E4185_09005	ENOG4105DDV	Transcriptional regulator (LacI family
E4185_09015	ENOG4105HDK	L-asparaginase
E4185_09030	ENOG4108Z5K	methylglyoxal synthase
E4185_09035	ENOG4108UQY	Iron-storage protein
E4185_09050	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
E4185_09065	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
E4185_09070	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
E4185_09090	ENOG4107VFP	cytochrome oxidase assembly
E4185_09095	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E4185_09100	ENOG4105C26	Dehydrogenase
E4185_09105	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
E4185_09110	ENOG4105D81	ABC transporter, permease
E4185_09115	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4185_09120	ENOG4107TYH	extracellular solute-binding protein family 1
E4185_09125	ENOG4108M0I	Transcriptional regulator
E4185_09130	ENOG4105DFD	Na H antiporter
E4185_09170	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
E4185_09175	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E4185_09180	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E4185_09185	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E4185_09195	ENOG4107VXZ	Hydrolase
E4185_09200	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E4185_09210	ENOG4105DY2	Paraquat-inducible protein b
E4185_09215	ENOG4108Q2G	(LipO)protein
E4185_09220	ENOG4105UYK	outer membrane protein a
E4185_09240	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
E4185_09245	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
E4185_09250	ENOG4105CEN	a g-specific adenine glycosylase
E4185_09265	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E4185_09270	ENOG4105CJ3	phosphate transporter
E4185_09275	ENOG4107IX6	phosphate transport regulator
E4185_09285	ENOG4108XTF	Outer Membrane Lipoprotein
E4185_09305	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E4185_09310	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E4185_09315	ENOG4105VEJ	Heat shock protein
E4185_09325	ENOG4105GVR	general secretion pathway protein D
E4185_09330	ENOG4107QHF	type ii secretion system protein e
E4185_09335	ENOG4105D7Q	type ii secretion system
E4185_09340	ENOG4108VAU	general secretion pathway protein G
E4185_09390	ENOG4108UDW	Transcriptional regulator, luxr family
E4185_09395	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4185_09400	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
E4185_09405	ENOG4107RK2	ADP-ribose diphosphatase NudE
E4185_09410	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E4185_09415	ENOG4105C44	Serine transporter
E4185_09420	ENOG4108Z7R	Chaperone CsaA
E4185_09430	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
E4185_09435	ENOG4105C28	cystathionine
E4185_09440	ENOG4105CFH	Aspartokinase
E4185_09445	ENOG41067MG	lrgb family
E4185_09455	ENOG4105CMU	LysR family (Transcriptional regulator
E4185_09485	ENOG4108Z66	YbaK ebsC protein
E4185_09490	ENOG4105BZU	Histidine kinase
E4185_09495	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
E4185_09505	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
E4185_09510	ENOG4105CAS	nag kinase
E4185_09520	ENOG4105CDH	Citrulline--aspartate ligase
E4185_09525	ENOG4105CH7	arginosuccinase
E4185_09550	ENOG4108UW5	maltose o-acetyltransferase
E4185_09555	ENOG4107PU6	Membrane
E4185_09570	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
E4185_09585	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_09590	ENOG4105EYW	Ion transport protein
E4185_09600	ENOG4105E09	nadh pyrophosphatase
E4185_09605	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E4185_09610	ENOG4105DKQ	ROK family
E4185_09615	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E4185_09620	ENOG4105BZA	Phosphoglycerate kinase
E4185_09625	ENOG4105D2N	Aldolase
E4185_09650	ENOG4105VF7	tolerance protein
E4185_09685	ENOG4108IYU	L-aspartate oxidase
E4185_09690	ENOG4105EMN	RNA polymerase sigma factor
E4185_09695	ENOG41069PW	sigma-e factor negative regulatory protein
E4185_09710	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E4185_09715	ENOG4105C3F	Signal peptidase i
E4185_09730	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
E4185_09735	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E4185_09740	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
E4185_09745	ENOG4108W15	Protein of unknown function (DUF1456)
E4185_09750	ENOG4105BZU	Histidine kinase
E4185_09755	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4185_09760	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4185_09765	ENOG4105DXN	mazG family
E4185_09770	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E4185_09775	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E4185_09780	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E4185_09785	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
E4185_09790	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
E4185_09795	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
E4185_09805	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
E4185_09810	ENOG4108UM1	dedA family
E4185_09815	ENOG4108K5P	(LipO)protein
E4185_09825	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4185_09830	ENOG4105VCC	30S ribosomal protein S21
E4185_09835	ENOG4105KTH	gatB Yqey
E4185_09840	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E4185_09845	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4185_09870	ENOG4105C12	Phosphoribosylglycinamide synthetase
E4185_09875	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E4185_09895	ENOG4105CSA	Coproporphyrinogen iii oxidase
E4185_09900	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E4185_09910	ENOG4105D9R	oxidoreductase
E4185_09920	ENOG4105G5H	Membrane
E4185_09925	ENOG4107QX8	SPFH domain, Band 7 family protein
E4185_09930	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E4185_09935	ENOG4105C11	sulfate adenylyltransferase), subunit 2
E4185_09940	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
E4185_09950	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
E4185_09955	ENOG4105F2I	Transposase
E4185_09990	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4185_10005	ENOG4108UUE	Transcriptional regulator
E4185_10020	ENOG4105F0N	pyrophosphate phospho-hydrolase
E4185_10025	ENOG4105DFU	Cell wall formation (By similarity)
E4185_10030	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
E4185_10035	ENOG410630P	Transcriptional regulator
E4185_10040	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E4185_10045	ENOG4105DA5	(ABC) transporter
E4185_10050	ENOG4105E3A	(ABC) transporter
E4185_10060	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
E4185_10065	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
E4185_10070	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4185_10075	ENOG4105DJ0	Poly(A) Polymerase
E4185_10080	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
E4185_10090	ENOG4105PW4	Sugar fermentation stimulation protein homolog
E4185_10095	ENOG4108784	2'-5' rna ligase
E4185_10100	ENOG4105CQ7	ATP-dependent helicase
E4185_10105	ENOG4105BZ4	penicillin-binding protein
E4185_10110	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
E4185_10115	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
E4185_10120	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
E4185_10125	ENOG4105EGI	Transcriptional regulator
E4185_10150	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E4185_10155	ENOG4105CMQ	Chloride channel
E4185_10165	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E4185_10190	ENOG4108NIW	Leucine export protein LeuE
E4185_10215	ENOG4105D70	Integrase catalytic subunit
E4185_10220	ENOG4105F5W	AtP-binding protein
E4185_10300	ENOG4108YGG	dna repair protein
E4185_10375	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4185_10385	ENOG4105E6M	Sulphatase-modifying factor protein
E4185_10395	ENOG4105YB8	TM2 domain containing protein
E4185_10400	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
E4185_10405	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E4185_10415	ENOG4107V40	secretion protein, HlyD family
E4185_10445	ENOG4105I93	response regulator
E4185_10450	ENOG4105DUX	Transporter
E4185_10455	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E4185_10460	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
E4185_10465	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E4185_10470	ENOG4105K9H	YciI-like protein
E4185_10475	ENOG4107835	probably involved in intracellular septation (By similarity)
E4185_10480	ENOG4105DY8	decarboxylase
E4185_10485	ENOG4108UT2	hemolysin iii
E4185_10490	ENOG4105D0C	transport protein
E4185_10500	ENOG4105EV4	Multidrug resistance protein mdtH
E4185_10510	ENOG4105D4Y	metalloprotease
E4185_10520	ENOG4105D9U	N-acetyltransferase
E4185_10540	ENOG4105CUY	Mechanosensitive ion channel
E4185_10545	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4185_10550	ENOG4105CK7	Sodium proline symporter
E4185_10590	ENOG4105D6S	protein involved in catabolism of external DNA
E4185_10605	ENOG41080XP	Cbs domain
E4185_10610	ENOG4105FCK	Membrane
E4185_10620	ENOG4108UJV	acyl-CoA thioesterase i
E4185_10625	ENOG4108I0Y	(ABC) transporter
E4185_10635	ENOG4105ECP	epimerase
E4185_10640	ENOG4105BZU	Histidine kinase
E4185_10645	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E4185_10650	ENOG4105IIU	Aminopeptidase
E4185_10655	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E4185_10660	ENOG41090ED	Protein with unknown function (DUF469)
E4185_10665	ENOG4105CSV	Glutaminase
E4185_10670	ENOG4107RM6	sulfurtransferase
E4185_10675	ENOG4105SUV	lipoprotein YgdR
E4185_10730	ENOG4105BZU	Histidine kinase
E4185_10735	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4185_10770	ENOG4105F2I	Transposase
E4185_10795	ENOG4105F2I	Transposase
E4185_10800	ENOG4105CT4	transporter
E4185_10810	ENOG4105ETE	Transcriptional regulator (LacI family
E4185_10815	ENOG4105W3H	MtN3 and saliva related transmembrane protein
E4185_10820	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4185_10825	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E4185_10830	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
E4185_10835	ENOG4105CMR	udp-glucose 4-epimerase
E4185_10850	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
E4185_10855	ENOG4105BZU	Histidine kinase
E4185_10865	ENOG4108K01	transcriptional regulator
E4185_10885	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
E4185_10890	ENOG4105DJ4	phosphatidylserine decarboxylase
E4185_10900	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
E4185_10935	ENOG4105VEQ	Cold shock protein
E4185_10945	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_10950	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E4185_10955	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E4185_11005	ENOG4109015	Biopolymer transport protein exbD tolR
E4185_11030	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
E4185_11035	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
E4185_11040	ENOG4107QRA	Extracellular solute-binding protein, family 5
E4185_11050	ENOG4108JQ7	(ABC) transporter
E4185_11060	ENOG4105CIN	aminoacyl-histidine dipeptidase
E4185_11075	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
E4185_11080	ENOG4105V1F	Fermentation respiration switch protein
E4185_11085	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
E4185_11095	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
E4185_11140	ENOG4105DG7	nitrate ABC transporter
E4185_11145	ENOG4105D7T	ABC transporter
E4185_11150	ENOG4107QZF	nitrite reductase NADPH large subunit
E4185_11155	ENOG4107QZF	nitrite reductase NADPH large subunit
E4185_11160	ENOG4105DD7	kinase (PfkB family
E4185_11165	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
E4185_11210	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4185_11240	ENOG4105C84	Histidine ammonia-lyase
E4185_11265	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4185_11275	ENOG4105C2D	reductase
E4185_11280	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4185_11290	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
E4185_11305	ENOG4105DWK	Membrane
E4185_11310	ENOG4107XM3	UPF0442 protein
E4185_11320	ENOG4108IJ7	Glycine betaine
E4185_11325	ENOG4108HQS	Glycine betaine
E4185_11330	ENOG4105GIJ	Glycine betaine
E4185_11335	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
E4185_11340	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
E4185_11345	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
E4185_11350	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
E4185_11355	ENOG4105CRK	lysyL-tRNA synthetase
E4185_11365	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_11370	ENOG4105BZU	Histidine kinase
E4185_11380	ENOG4105BZU	Histidine kinase
E4185_11385	ENOG4105D6U	Sodium Glutamate Symporter
E4185_11390	ENOG4105HDK	L-asparaginase
E4185_11395	ENOG4105VUT	cytoplasmic protein
E4185_11415	ENOG4105D07	Signal peptide peptidase, SppA
E4185_11420	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4185_11425	ENOG41069NU	Nitroreductase
E4185_11435	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E4185_11440	ENOG4105CIS	alcohol dehydrogenase
E4185_11445	ENOG4105HEI	LysR family (Transcriptional regulator
E4185_11450	ENOG4105CI1	PTS System
E4185_11455	ENOG4108IA2	Sodium pantothenate symporter
E4185_11460	ENOG4105RG0	Membrane
E4185_11465	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E4185_11470	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E4185_11475	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
E4185_11480	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E4185_11485	ENOG4105BZU	Histidine kinase
E4185_11495	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
E4185_11500	ENOG4108EM1	reductase
E4185_11505	ENOG4105CUW	cytochrome C-TYPE protein
E4185_11510	ENOG4106WF9	DNA-binding transcriptional regulator TorR
E4185_11520	ENOG4108SV3	Tmao reductase system periplasmic protein tort
E4185_11525	ENOG4105BZU	Histidine kinase
E4185_11535	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E4185_11550	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E4185_11570	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E4185_11575	ENOG4107YIM	Involved in the transcription termination process (By similarity)
E4185_11580	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
E4185_11585	ENOG4108ZAI	phosphatidylglycerophosphatase a
E4185_11590	ENOG4108JQ6	ABC transporter
E4185_11600	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4185_11610	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E4185_11615	ENOG4105CTB	Polyprenyl synthetase
E4185_11620	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4185_11625	ENOG4105E14	MotA TolQ exbB proton channel
E4185_11630	ENOG4107XSU	flagellar motor protein motb
E4185_11635	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E4185_11645	ENOG4105HBR	Rna-binding protein
E4185_11650	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E4185_11655	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E4185_11660	ENOG4105EEI	dihydropteroate synthase
E4185_11665	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E4185_11670	ENOG4105CP7	Triose-phosphate isomerase
E4185_11675	ENOG4105NTZ	Preprotein translocase subunit SecG
E4185_11690	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E4185_11695	ENOG4105CHV	Transcription elongation factor NusA
E4185_11700	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E4185_11705	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E4185_11710	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E4185_11715	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E4185_11720	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E4185_11725	ENOG4105E5W	Transporter
E4185_11730	ENOG41090EX	DsrE family
E4185_11735	ENOG4105WAY	exported protein
E4185_11740	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
E4185_11745	ENOG4105CFP	Peptidase U32
E4185_11750	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4185_11765	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E4185_11775	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
E4185_11790	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E4185_11805	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E4185_11815	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4185_11825	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E4185_11835	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E4185_11840	ENOG4108Z43	UPF0250 protein
E4185_11845	ENOG4105DZ1	carboxypeptidase
E4185_11850	ENOG4105K6T	rare lipoprotein A
E4185_11855	ENOG4105CVE	Lytic murein transglycosylase
E4185_11860	ENOG4105CNI	cell division protein FtsW
E4185_11865	ENOG4105CJN	penicillin-binding protein
E4185_11870	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E4185_11875	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
E4185_11880	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E4185_11895	ENOG4105C8T	Leucyl-tRNA synthetase
E4185_11900	ENOG4107PAI	alpha helical protein
E4185_11905	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E4185_11910	ENOG4108JU5	Magnesium and cobalt efflux protein
E4185_11915	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E4185_11920	ENOG4105C9A	Phoh family
E4185_11925	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E4185_11930	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E4185_11935	ENOG4105VEQ	Cold shock protein
E4185_11940	ENOG4105F04	LysR family Transcriptional regulator
E4185_11950	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
E4185_11980	ENOG4105C5I	Dehydrogenase
E4185_11995	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E4185_12005	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4185_12015	ENOG4105DHQ	Histidine kinase
E4185_12020	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4185_12030	ENOG4108IXY	short-chain dehydrogenase reductase
E4185_12040	ENOG4108IQE	Amp-dependent synthetase and ligase
E4185_12050	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
E4185_12055	ENOG4105T0Z	Conserved Protein
E4185_12060	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
E4185_12065	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
E4185_12070	ENOG4105E33	succinate dehydrogenase
E4185_12080	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_12085	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E4185_12090	ENOG4105EGS	Mechanosensitive ion channel
E4185_12100	ENOG4105DR5	peptidase
E4185_12105	ENOG4108VEV	chaperone
E4185_12115	ENOG4108VEV	chaperone
E4185_12130	ENOG4105EJC	lysr family transcriptional regulator
E4185_12145	ENOG4105C5Q	Transcriptional regulator
E4185_12150	ENOG4108JQC	penicillin-binding protein 1A
E4185_12180	ENOG4105E4G	Type IV pilus
E4185_12185	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E4185_12190	ENOG4105D49	3-dehydroquinate synthase
E4185_12200	ENOG4105DFE	Dna adenine methylase
E4185_12205	ENOG4105DJV	ribulose-phosphate 3-epimerase
E4185_12210	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E4185_12215	ENOG4105C31	Tryptophanyl-tRNA synthetase
E4185_12230	ENOG4105C8Y	Acetylornithine aminotransferase
E4185_12235	ENOG4105F4X	arginine
E4185_12240	ENOG4105C26	Dehydrogenase
E4185_12250	ENOG4107VXZ	Hydrolase
E4185_12270	ENOG4105N5Z	UPF0267 protein
E4185_12275	ENOG4107QWE	)-transporter
E4185_12320	ENOG4105C3G	gtp-binding protein
E4185_12325	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E4185_12330	ENOG4105CGH	5'-nucleotidase
E4185_12335	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E4185_12345	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E4185_12350	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
E4185_12355	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
E4185_12360	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E4185_12365	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E4185_12375	ENOG41063JG	Transcriptional regulator
E4185_12380	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E4185_12385	ENOG4105CK2	sodium dicarboxylate symporter
E4185_12390	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
E4185_12395	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E4185_12410	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E4185_12415	ENOG4105BZG	amino acid carrier protein
E4185_12420	ENOG41066YJ	Beta-lactamase
E4185_12440	ENOG4105G2Y	Transcriptional regulator
E4185_12445	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E4185_12465	ENOG4105D7Z	glutathione synthase
E4185_12470	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E4185_12480	ENOG4105GPY	SprT protein
E4185_12485	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E4185_12490	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E4185_12510	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
E4185_12515	ENOG4105DR5	peptidase
E4185_12520	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4185_12525	ENOG4107WCA	isomerase
E4185_12535	ENOG4108V1U	phospholipid-binding protein
E4185_12540	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E4185_12555	ENOG4105C87	Aminotransferase class I and II
E4185_12565	ENOG4105C5Q	Transcriptional regulator
E4185_12570	ENOG4105UBK	short-chain dehydrogenase reductase
E4185_12575	ENOG4105ERU	peptidase
E4185_12580	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
E4185_12585	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E4185_12595	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
E4185_12605	ENOG4105RD7	BadF BadG BcrA BcrD
E4185_12615	ENOG4108JQ7	(ABC) transporter
E4185_12625	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4185_12640	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
E4185_12655	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
E4185_12660	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
E4185_12670	ENOG4108JIR	Flagellum-specific ATP synthase
E4185_12690	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
E4185_12695	ENOG4105DD5	Flagellar motor switch protein
E4185_12700	ENOG4105VTB	flagellar biosynthesis protein fliO
E4185_12705	ENOG4105CN7	Flagellar biosynthetic protein FliP
E4185_12710	ENOG4105VS8	Flagellar biosynthetic protein fliq
E4185_12715	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
E4185_12720	ENOG4105D00	flagellar biosynthetic protein flhB
E4185_12725	ENOG4105D7B	Flagellar biosynthesis protein flha
E4185_12730	ENOG4105FZW	flagellar biosynthesis regulator FlhF
E4185_12740	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4185_12745	ENOG4108VYJ	response regulator receiver protein
E4185_12750	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
E4185_12760	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
E4185_12765	ENOG4105E14	MotA TolQ exbB proton channel
E4185_12770	ENOG4108SEK	ompa motb domain protein
E4185_12775	ENOG4107QJE	Chromosome Partitioning Protein
E4185_12785	ENOG4108V3W	Chemotaxis protein, CheW
E4185_12805	ENOG41060IM	Heme exporter protein
E4185_12810	ENOG4105X3C	heme exporter protein
E4185_12815	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E4185_12820	ENOG4105DA4	cytochrome c-type biogenesis protein
E4185_12825	ENOG4107QX9	Thiol disulfide interChange protein
E4185_12830	ENOG4105KWW	Biogenesis protein
E4185_12840	ENOG410903C	(LipO)protein
E4185_12850	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E4185_12855	ENOG4105M2J	Glutaredoxin
E4185_12875	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E4185_12880	ENOG4107R11	Transcriptional regulator
E4185_12885	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
E4185_12890	ENOG4106FVC	RNA methyltransferase
E4185_12905	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
E4185_12910	ENOG4105D98	threonine synthase
E4185_12915	ENOG4108VSZ	Inherit from COG: ketosteroid isomerase-like protein
E4185_12935	ENOG410600T	transposase
E4185_12965	ENOG4108UK5	Transposase
E4185_13000	ENOG4107SDU	Methyl-accepting chemotaxis
E4185_13010	ENOG4108ESY	Metal dependent phosphohydrolase
E4185_13015	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
E4185_13020	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
E4185_13025	ENOG4107R1I	NAD-dependent malic enzyme
E4185_13030	ENOG4105C2W	permease
E4185_13045	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E4185_13055	ENOG4105EGS	Mechanosensitive ion channel
E4185_13060	ENOG4105CA9	Pyruvate kinase
E4185_13065	ENOG4105EZE	Cupin 4 family protein
E4185_13070	ENOG4107QTF	adenylosuccinate lyase
E4185_13075	ENOG41075W9	High frequency lysogenization protein HflD homolog
E4185_13080	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E4185_13090	ENOG4108R99	pseudouridine synthase
E4185_13100	ENOG4108YRF	PTS System
E4185_13105	ENOG4105CXY	transporter
E4185_13110	ENOG4105DM4	PTS System
E4185_13140	ENOG4107VGF	ig domain protein group 2 domain protein
E4185_13160	ENOG4105EIP	mannose-6-phosphate isomerase
E4185_13165	ENOG4106R3P	AraC family transcriptional regulator
E4185_13170	ENOG4108HMX	isocitrate dehydrogenase (NADP)
E4185_13180	ENOG4105BZC	d-serine deaminase
E4185_13190	ENOG4105W8I	Transcriptional regulator
E4185_13210	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E4185_13215	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4185_13220	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
E4185_13230	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
E4185_13235	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E4185_13240	ENOG4105BZU	Histidine kinase
E4185_13245	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E4185_13250	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4185_13255	ENOG4105CFG	Acts as a chaperone (By similarity)
E4185_13260	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4185_13280	ENOG4108HKT	sucrose-6-phosphate hydrolase
E4185_13285	ENOG4105WBN	Transcriptional regulator (LacI family
E4185_13315	ENOG4105KFG	YeeE YedE family protein
E4185_13330	ENOG4105EFX	secretion protein, HlyD family
E4185_13335	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4185_13340	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4185_13345	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4185_13350	ENOG4105BZU	Histidine kinase
E4185_13355	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
E4185_13360	ENOG410600T	transposase
E4185_13385	ENOG4108IJF	Heavy metal efflux pump, CzcA
E4185_13390	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
E4185_13400	ENOG4105CGK	Exodeoxyribonuclease III
E4185_13415	ENOG4105VN1	Heat shock protein
E4185_13455	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
E4185_13460	ENOG4105E2S	oxidase) subunit II
E4185_13465	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E4185_13470	ENOG4105CCU	oxidase (Subunit III)
E4185_13475	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
E4185_13505	ENOG4105JQN	Transcriptional regulator
E4185_13525	ENOG4105CAF	HipA N-terminal domain protein
E4185_13545	ENOG4105F2I	Transposase
E4185_13555	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
E4185_13560	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E4185_13570	ENOG4108EFP	Anthranilate synthase component II
E4185_13575	ENOG4105CRQ	synthase (Component I)
E4185_13585	ENOG4105DB7	PHP domain protein
E4185_13590	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
E4185_13600	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E4185_13605	ENOG4105FE9	pseudouridine synthase
E4185_13615	ENOG4105C29	acyl-CoA thioesterase
E4185_13630	ENOG4108IG5	Transcriptional regulator
E4185_13635	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
E4185_13640	ENOG4105BZS	acriflavin resistance protein
E4185_13645	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E4185_13655	ENOG4107SSZ	Phosphatase
E4185_13665	ENOG4107QPN	acyl-Coa dehydrogenase
E4185_13670	ENOG4105BZS	acriflavin resistance protein
E4185_13680	ENOG4105CA9	Pyruvate kinase
E4185_13685	ENOG4106KNT	transcriptional regulator
E4185_13695	ENOG4105IFJ	Histidine kinase
E4185_13700	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4185_13705	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E4185_13710	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
E4185_13720	ENOG4105J5G	Transferase hexapeptide repeat containing protein
E4185_13735	ENOG4105CKK	Glycosyl transferase, family 2
E4185_13740	ENOG4105K64	Glycosyl transferase, family 2
E4185_13745	ENOG4105CG5	Glycosyl transferase (Group 1
E4185_13755	ENOG4107QPH	glycogen) synthase
E4185_13770	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
E4185_13775	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
E4185_13780	ENOG4108QY5	Ferric enterobactin transport protein
E4185_13795	ENOG4108YXG	UPF0502 protein
E4185_13805	ENOG4105KR1	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)
E4185_13820	ENOG4107RUY	(E1 component), alpha subunit
E4185_13825	ENOG4105CPP	Dehydrogenase, E1 component
E4185_13830	ENOG4107QSN	dihydrolipoamide acetyltransferase
E4185_13835	ENOG4105VEQ	Cold shock protein
E4185_13865	ENOG4108594	Permease of the drug metabolite transporter
E4185_13875	ENOG4105CPI	Metal Dependent Phosphohydrolase
E4185_13880	ENOG4105I08	Pseudouridine synthase
E4185_13890	ENOG4107QSI	ABC, transporter
E4185_13895	ENOG4108RE9	Phosphodiesterase
E4185_13910	ENOG4107ESN	Flagella basal body P-ring formation protein flgA
E4185_13920	ENOG4105BZU	Histidine kinase
E4185_13925	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
E4185_13930	ENOG4108ZC9	flagellar basal-body rod protein flgc
E4185_13940	ENOG4105BZE	flagellar hook protein, FlgE
E4185_13945	ENOG4108KPB	Flagellar basal-body rod protein FlgF
E4185_13950	ENOG4105CGA	flagellar basal-body rod protein FlgG
E4185_13955	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E4185_13960	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E4185_13980	ENOG4105CJW	magnesium transporter
E4185_13985	ENOG4105C9X	ppx gppa phosphatase
E4185_13990	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
E4185_13995	ENOG4105RH4	Glycine cleavage system transcriptional repressor
E4185_14010	ENOG4105BZU	Histidine kinase
E4185_14025	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E4185_14030	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E4185_14035	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E4185_14045	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
E4185_14050	ENOG4108I9X	Isocitrate lyase
E4185_14055	ENOG4107QP3	malate synthase g
E4185_14070	ENOG4108Z6B	deaminase
E4185_14075	ENOG4105C8U	phosphate abc transporter
E4185_14080	ENOG4105E2Z	phosphate ABC transporter (Permease
E4185_14085	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E4185_14090	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
E4185_14095	ENOG4105C37	(CBS) domain
E4185_14105	ENOG4105C3R	Methionine synthase
E4185_14110	ENOG4105D5Q	Arginine ornithine antiporter
E4185_14125	ENOG4105CDA	abc transporter atp-binding protein
E4185_14135	ENOG4106PMH	Extracellular solute-binding protein family 3
E4185_14140	ENOG4105BZU	Histidine kinase
E4185_14145	ENOG4105CXY	transporter
E4185_14150	ENOG4105BZU	Histidine kinase
E4185_14155	ENOG4108KX4	response regulator
E4185_14160	ENOG4105NXH	GreA GreB family elongation factor
E4185_14185	ENOG4105G6Z	alkaline phosphatase
E4185_14190	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E4185_14195	ENOG4108ISG	Major Facilitator
E4185_14200	ENOG4105DGU	Histone deacetylase
E4185_14210	ENOG4105DVT	helicase
E4185_14225	ENOG4105CGF	Aromatic amino acid aminotransferase
E4185_14230	ENOG4105D7A	ATP-binding protein
E4185_14245	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E4185_14250	ENOG4105BZ1	(ABC) transporter
E4185_14255	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
E4185_14260	ENOG4105W49	UPF0434 protein
E4185_14265	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
E4185_14270	ENOG4105WH1	Two component transcriptional regulator luxr family
E4185_14330	ENOG4105C0D	helicase
E4185_14390	ENOG4105F2I	Transposase
E4185_14400	ENOG4105YB8	TM2 domain containing protein
E4185_14430	ENOG4107R3N	Filamentation induced by cAMP protein fic
E4185_14440	ENOG4108TGY	Glutathione S-transferase
E4185_14445	ENOG4105Y3U	Transglycosylase-associated protein
E4185_14450	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
E4185_14460	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E4185_14465	ENOG4105C8N	cysteinyl-tRNA synthetase
E4185_14500	ENOG410620I	Diguanylate cyclase
E4185_14540	ENOG4108ZJT	translation initiation factor, Sui1
E4185_14560	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E4185_14565	ENOG4105CZX	twitching motility protein
E4185_14580	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
E4185_14590	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4185_14595	ENOG41080IJ	Diacylglycerol kinase
E4185_14600	ENOG4108JQ1	Dehydrogenase
E4185_14605	ENOG4105E66	phosphoriboisomerase A
E4185_14610	ENOG4105E66	phosphoriboisomerase A
E4185_14625	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E4185_14630	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E4185_14635	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E4185_14645	ENOG4106TD9	Diguanylate cyclase
E4185_14650	ENOG4107QS8	(LipO)protein
E4185_14670	ENOG4105C1J	atp-dependent rna helicase
E4185_14685	ENOG4108Z4X	TRANSCRIPTIONal
E4185_14695	ENOG4105BZ8	glutamate synthase
E4185_14700	ENOG4105CBC	glutamate synthase
E4185_14705	ENOG4105N5T	Radical SAM Protein
E4185_14715	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
E4185_14760	ENOG4105C85	amino acid
E4185_14770	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4185_14775	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E4185_14790	ENOG4105DKW	ABC transporter
E4185_14800	ENOG4105F2I	Transposase
E4185_14810	ENOG4105D01	(LipO)protein
E4185_14815	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
E4185_14820	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
E4185_14825	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E4185_14835	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E4185_14840	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E4185_14845	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E4185_14850	ENOG4108S3P	Sporulation domain protein
E4185_14855	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
E4185_14860	ENOG4105EM2	membrane
E4185_14865	ENOG4108MN8	Membrane
E4185_14875	ENOG4105C7F	AcnD-accessory protein PrpF
E4185_14880	ENOG4108I0Z	Aconitate hydratase
E4185_14885	ENOG4105BZN	citrate synthase
E4185_14890	ENOG4105CR4	methylisocitrate lyase
E4185_14895	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
E4185_14910	ENOG4108J8C	transporter major facilitator family protein
E4185_14920	ENOG4105HMI	Membrane
E4185_14945	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
E4185_14975	ENOG4105BZU	Histidine kinase
E4185_14980	ENOG4108W1A	pseudouridine synthase
E4185_14990	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
E4185_14995	ENOG4105F1J	Homogentisate 1,2-dioxygenase
E4185_15005	ENOG4108RXX	maleylacetoacetate isomerase
E4185_15020	ENOG4105CAQ	asparagine synthetase
E4185_15030	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
E4185_15035	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4185_15040	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4185_15045	ENOG4105EE5	Membrane protein terC
E4185_15065	ENOG4105KA0	thioesterase Superfamily protein
E4185_15070	ENOG4105C1J	atp-dependent rna helicase
E4185_15085	ENOG4105D3Y	Na H antiporter
E4185_15090	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
E4185_15100	ENOG4105EIY	sodium-type flagellar protein motY
E4185_15105	ENOG4105ECY	inositol monophosphatase
E4185_15120	ENOG4105CYM	Glutathione S-transferase
E4185_15130	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4185_15135	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4185_15140	ENOG4105C3U	ABC transporter
E4185_15145	ENOG4105E5M	Multidrug resistance protein D
E4185_15155	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
E4185_15165	ENOG4105D0A	hydroxylase
E4185_15170	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E4185_15175	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E4185_15180	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E4185_15185	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4185_15190	ENOG4105GR3	Histidine kinase
E4185_15195	ENOG4105D5G	Transposase
E4185_15225	ENOG4105D3R	alkyl hydroperoxide reductase
E4185_15230	ENOG4105W87	Cbs domain
E4185_15235	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E4185_15240	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E4185_15245	ENOG4105VIE	preprotein translocase, subunit YajC
E4185_15250	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4185_15260	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E4185_15295	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
E4185_15300	ENOG4105C3J	Cysteine desulfurase
E4185_15305	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
E4185_15310	ENOG4108Z4V	iron-sulfur cluster assembly
E4185_15320	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
E4185_15325	ENOG4108ZIT	Ferredoxin, 2FE-2S
E4185_15335	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4185_15340	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E4185_15345	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E4185_15355	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
E4185_15360	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E4185_15365	ENOG4105CUT	histidyl-tRNA synthetase
E4185_15370	ENOG4105N21	Membrane
E4185_15375	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4185_15380	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E4185_15390	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4185_15400	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4185_15405	ENOG4105C8S	subunit m
E4185_15410	ENOG4105D65	subunit l
E4185_15415	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4185_15420	ENOG4107UFS	subunit j
E4185_15425	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4185_15430	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
E4185_15435	ENOG4108IEH	NADH dehydrogenase subunit g
E4185_15445	ENOG4105GKE	subunit e
E4185_15450	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4185_15455	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4185_15460	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4185_15465	ENOG4105ER2	Ompa motb domain protein
E4185_15470	ENOG4105E14	MotA TolQ exbB proton channel
E4185_15485	ENOG4105HA9	of methanol dehydrogenase type
E4185_15495	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
E4185_15505	ENOG4105VFU	Rna-binding protein
E4185_15510	ENOG4107RGM	aldo keto reductase
E4185_15535	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4185_15540	ENOG4105CBN	LysR family transcriptional regulator
E4185_15555	ENOG4105CFC	Transporter
E4185_15560	ENOG4108DBC	nitroreductase
E4185_15575	ENOG4105D2S	major facilitator superfamily
E4185_15580	ENOG4105DUM	transcriptional regulator, lysR family
E4185_15585	ENOG4108JEN	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
E4185_15590	ENOG4105CAT	Cytidine monophosphate kinase
E4185_15595	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E4185_15600	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E4185_15615	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E4185_15630	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
E4185_15635	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E4185_15640	ENOG4105VRT	cytoplasmic protein
E4185_15645	ENOG4108WBT	adenosyltransferase
E4185_15655	ENOG4107S6Z	Na H antiporter
E4185_15660	ENOG4107104	thymidine kinase
E4185_15670	ENOG4108RMJ	sensory transduction regulator
E4185_15680	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
E4185_15695	ENOG4105CAF	HipA N-terminal domain protein
E4185_15795	ENOG41086KC	Transcriptional regulator
E4185_15800	ENOG4108XDW	curli assembly protein CsgE
E4185_15810	ENOG4105P8Q	Curli production assembly transport component CsgG
E4185_15875	ENOG4105D70	Integrase catalytic subunit
E4185_15880	ENOG4105F5W	AtP-binding protein
E4185_15910	ENOG4108UUM	single-stranded DNA-binding protein
E4185_15915	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E4185_15960	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4185_16040	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
E4185_16080	ENOG4105EQR	Transposase IS116 IS110 IS902
E4185_16120	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E4185_16135	ENOG4108RYK	Nad-dependent epimerase dehydratase
E4185_16140	ENOG4105JQN	Transcriptional regulator
E4185_16165	ENOG4105DZ2	Transcriptional regulator
E4185_16170	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
E4185_16190	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
E4185_16195	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
E4185_16205	ENOG41061WM	D-Alanyl-D-Alanine
E4185_16210	ENOG4108DMF	Cytochrome C biogenesis protein
E4185_16215	ENOG4107QX9	Thiol disulfide interChange protein
E4185_16225	ENOG4105DVI	reductase, NrfD
E4185_16230	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E4185_16235	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
E4185_16250	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
E4185_16260	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
E4185_16265	ENOG4105K5B	UPF0225 protein
E4185_16270	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_16275	ENOG4105E2R	ROK family
E4185_16280	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
E4185_16285	ENOG4108MRH	transcriptional regulatory protein
E4185_16310	ENOG4105D0C	transport protein
E4185_16325	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E4185_16335	ENOG4105DQR	SNARE associated Golgi
E4185_16350	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E4185_16355	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
E4185_16360	ENOG4105ED1	spovr family
E4185_16365	ENOG4106AKX	UPF0229 protein
E4185_16370	ENOG4105CYN	Serine protein kinase
E4185_16375	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4185_16380	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
E4185_16385	ENOG4105C44	Serine transporter
E4185_16395	ENOG4105CRQ	synthase (Component I)
E4185_16415	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
E4185_16425	ENOG4105C8P	)-transporter
E4185_16430	ENOG4105K63	Thioredoxin
E4185_16445	ENOG4105BZ1	(ABC) transporter
E4185_16460	ENOG4105WQ3	Rna-binding protein
E4185_16470	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
E4185_16490	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
E4185_16495	ENOG41061CK	Antibiotic biosynthesis monooxygenase
E4185_16500	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
E4185_16510	ENOG4105DUM	transcriptional regulator, lysR family
E4185_16520	ENOG4105D1S	lipid A biosynthesis
E4185_16540	ENOG4105EUB	pirin domain protein
E4185_16550	ENOG4105CQ2	DNA polymerase
E4185_16580	ENOG4107QI1	Mate efflux family protein
E4185_16585	ENOG4105W1I	UPF0253 protein
E4185_16590	ENOG4108R6K	riboflavin synthase, subunit alpha
E4185_16600	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
E4185_16605	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
E4185_16610	ENOG4108SXK	Transporter Drug Metabolite Exporter family
E4185_16615	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
E4185_16645	ENOG4105XW2	UPF0263 protein
E4185_16650	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
E4185_16655	ENOG4108W5H	UPF0263 protein
E4185_16660	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
E4185_16665	ENOG4107QMS	site-determining protein
E4185_16670	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
E4185_16675	ENOG4105VNG	YcgL domain-containing protein
E4185_16680	ENOG4105CVE	Lytic murein transglycosylase
E4185_16685	ENOG4105EJQ	L-serine dehydratase
E4185_16695	ENOG4105EJQ	L-serine dehydratase
E4185_16700	ENOG4105NBK	UPF0345 protein
E4185_16740	ENOG410600T	transposase
E4185_16770	ENOG4105D5G	Transposase
E4185_16845	ENOG410600T	transposase
E4185_16925	ENOG4105CHU	acetyl-coa acetyltransferase
E4185_16930	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4185_16935	ENOG4105D58	Diguanylate phosphodiesterase
E4185_16940	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4185_16945	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4185_16990	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E4185_16995	ENOG4105CHU	acetyl-coa acetyltransferase
E4185_17000	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E4185_17010	ENOG4108VWS	Yaeq family
E4185_17035	ENOG4105EHG	Permease protein
E4185_17050	ENOG4107MBR	17 kDa surface antigen
E4185_17055	ENOG4105CEY	Amp-dependent synthetase and ligase
E4185_17060	ENOG4105D29	Helix-turn-helix type 11 domain protein
E4185_17070	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
E4185_17075	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
E4185_17090	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4185_17095	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
E4185_17100	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
E4185_17110	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E4185_17120	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
E4185_17130	ENOG4105DVT	helicase
E4185_17170	ENOG4105CEY	Amp-dependent synthetase and ligase
E4185_17175	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E4185_17185	ENOG4105DXC	membrane
E4185_17195	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
E4185_17200	ENOG4105WD1	Membrane
E4185_17205	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E4185_17215	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E4185_17220	ENOG4105CHJ	isochorismatase hydrolase
E4185_17225	ENOG4105EUB	pirin domain protein
E4185_17235	ENOG4105DWD	nucleoside recognition domain protein
E4185_17240	ENOG4105WH1	Two component transcriptional regulator luxr family
E4185_17250	ENOG4105CQ7	ATP-dependent helicase
E4185_17260	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E4185_17270	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4185_17275	ENOG4105C5X	domain protein
E4185_17280	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
E4185_17285	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
E4185_17295	ENOG4105DR4	Methyltransferase
E4185_17305	ENOG4108N3W	hemolysin secretion protein
E4185_17310	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
E4185_17320	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E4185_17325	ENOG4105D1F	ATP-binding protein
E4185_17330	ENOG4105DBI	uridine monophosphokinase
E4185_17335	ENOG4105DHP	deoxycytidine triphosphate deaminase
E4185_17340	ENOG4105CJ3	phosphate transporter
E4185_17345	ENOG4105D70	Integrase catalytic subunit
E4185_17415	ENOG4108BUD	transposase
E4185_17430	ENOG4108C33	Resolvase
E4185_17480	ENOG4105D5G	Transposase
E4185_17485	ENOG4105C03	ribonuclease
E4185_17490	ENOG4105EI2	Pseudouridine synthase
E4185_17495	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
E4185_17500	ENOG4108UHJ	MAF-like protein
E4185_17510	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
E4185_17515	ENOG4105VGS	50s ribosomal protein l32
E4185_17520	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E4185_17525	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4185_17530	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E4185_17535	ENOG4105CHR	reductase
E4185_17540	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4185_17545	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4185_17550	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
E4185_17555	ENOG4105HHA	aminodeoxychorismate lyase
E4185_17560	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E4185_17565	ENOG4107QRG	dna polymerase iii
E4185_17570	ENOG4105F8V	Hydrolase, tatD family
E4185_17605	ENOG4105DY2	Paraquat-inducible protein b
E4185_17610	ENOG4105H2K	paraquat-inducible protein a
E4185_17620	ENOG4105X2V	dna damage-inducible protein
E4185_17625	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4185_17705	ENOG4105DAN	ATP-dependent protease
E4185_17710	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
E4185_17715	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
E4185_17725	ENOG4105C5H	ABC transporter
E4185_17735	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E4185_17740	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
E4185_17745	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E4185_17750	ENOG4105C7I	Dehydrogenase
E4185_17760	ENOG4105CD8	aminopeptidase N
E4185_17765	ENOG4105CN1	protease
E4185_17770	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
E4185_17775	ENOG4108ZGC	gaf domain protein
E4185_17785	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
E4185_17800	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
E4185_17825	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E4185_17830	ENOG4105Q9Y	Universal stress protein
E4185_17835	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
E4185_17850	ENOG4108RXX	maleylacetoacetate isomerase
E4185_17855	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
E4185_17860	ENOG4105C2J	ABC transporter
E4185_17865	ENOG4105CNN	ABC, transporter
E4185_17870	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
E4185_17875	ENOG4108RVA	ribokinase
E4185_17880	ENOG4105ETE	Transcriptional regulator (LacI family
E4185_17885	ENOG4105BZU	Histidine kinase
E4185_17895	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E4185_17915	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E4185_17920	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E4185_17925	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E4185_17930	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E4185_17940	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E4185_17945	ENOG4105C22	threonyL-tRNA synthetase
E4185_17965	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4185_17970	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E4185_17975	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E4185_17980	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4185_17985	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4185_17990	ENOG4105XPH	Ferredoxin
E4185_17995	ENOG4105CA3	membrane-bound lytic murein transglycosylase
E4185_18000	ENOG4105XZD	Fe-S protein
E4185_18005	ENOG4105DM4	PTS System
E4185_18010	ENOG4105DE4	1-phosphofructokinase
E4185_18015	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
E4185_18020	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
E4185_18025	ENOG4105E0U	tyrosine-specific transport protein
E4185_18030	ENOG4105WJG	Glutathione
E4185_18035	ENOG4105C1J	atp-dependent rna helicase
E4185_18045	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E4185_18065	ENOG4107TB6	phosphoglycerate mutase
E4185_18095	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E4185_18105	ENOG410829K	Lysine exporter protein (Lyse ygga)
E4185_18115	ENOG4105JAB	phenazine biosynthesis protein, phzf family
E4185_18155	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
E4185_18160	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
E4185_18165	ENOG4106371	Methyltransferase
E4185_18170	ENOG4107S90	membrAne
E4185_18180	ENOG4105CTQ	phosphohexokinase
E4185_18185	ENOG4105CH2	amidohydrolase
E4185_18190	ENOG4105PAD	Hydrolase
E4185_18195	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4185_18245	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
E4185_18250	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4185_18260	ENOG4105VP0	transcriptional regulator, lysR family
E4185_18270	ENOG4106IUH	DTW domain containing protein
E4185_18285	ENOG4105CPF	Cell wall formation (By similarity)
E4185_18300	ENOG4105C1J	atp-dependent rna helicase
E4185_18305	ENOG4105K5X	acetyltransferase
E4185_18315	ENOG4105KK4	UPF0060 membrane protein
E4185_18340	ENOG4105BZU	Histidine kinase
E4185_18350	ENOG4105BZU	Histidine kinase
E4185_18355	ENOG410600T	transposase
E4185_18375	ENOG4105CBN	LysR family transcriptional regulator
E4185_18380	ENOG4105CHR	reductase
E4185_18390	ENOG4105DND	Transcriptional regulator
E4185_18395	ENOG4105BZU	Histidine kinase
E4185_18405	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
E4185_18410	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
E4185_18425	ENOG410642W	LysR family Transcriptional regulator
E4185_18430	ENOG410600T	transposase
E4185_18435	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
E4185_18440	ENOG4105C2J	ABC transporter
E4185_18445	ENOG4107R9N	ABC transporter
E4185_18500	ENOG4108C33	Resolvase
E4185_18580	ENOG4108YGG	dna repair protein
E4185_18610	ENOG4108HFV	
E4185_18625	ENOG4105CVR	type I restriction-modification system
E4185_18645	ENOG4105HF0	Membrane
E4185_18650	ENOG4105D5Q	Arginine ornithine antiporter
E4185_18655	ENOG4105CHR	reductase
E4185_18660	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E4185_18665	ENOG4105E39	Enoyl-CoA hydratase
E4185_18670	ENOG4105E39	Enoyl-CoA hydratase
E4185_18675	ENOG4105C1G	acyl-Coa dehydrogenase
E4185_18680	ENOG4105C26	Dehydrogenase
E4185_18685	ENOG4105C1G	acyl-Coa dehydrogenase
E4185_18690	ENOG4107QX3	carboxylase
E4185_18695	ENOG4105E39	Enoyl-CoA hydratase
E4185_18705	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
E4185_18720	ENOG4106HK8	GPR1 FUN34 yaaH family protein
E4185_18735	ENOG4105BZG	amino acid carrier protein
E4185_18740	ENOG41060WC	Enoyl-CoA hydratase
E4185_18750	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E4185_18755	ENOG41062QD	Membrane
E4185_18760	ENOG4107QN1	sodium solute
E4185_18765	ENOG4105C5H	ABC transporter
E4185_18770	ENOG4105EIN	peptidylprolyl cis-trans isomerase
E4185_18775	ENOG4105K70	DNA-binding protein
E4185_18780	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E4185_18785	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E4185_18790	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E4185_18795	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E4185_18815	ENOG4105D60	lipoprotein releasing system transmembrane protein
E4185_18820	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4185_18835	ENOG4108JA2	transcriptioN-repair coupling factor
E4185_18840	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4185_18845	ENOG4108J59	Extracellular solute-binding protein, family 5
E4185_18855	ENOG4108IPJ	Membrane
E4185_18865	ENOG4108BY2	phosphohistidine phosphatase
E4185_18875	ENOG4105FQ6	thiopurine methyltransferase
E4185_18910	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4185_18915	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4185_18925	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
E4185_18935	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4185_18940	ENOG4105D4P	Coproporphyrinogen iii oxidase
E4185_18945	ENOG41090EK	ompa motb domain protein
E4185_18950	ENOG4108KHX	Diguanylate cyclase
E4185_18955	ENOG4108WS1	
E4185_18965	ENOG41090A4	Pterin carbinolamine dehydratase
E4185_18970	ENOG4105MIR	Phenylalanine 4-monooxygenase
E4185_18975	ENOG4106K28	UPF0283 membrane protein
E4185_18980	ENOG4105CM6	amino acid regulated cytosolic protein
E4185_18990	ENOG4105YYT	phage shock protein B
E4185_18995	ENOG41087YS	Phage shock protein A
E4185_19000	ENOG4105E51	psp operon transcriptional activator
E4185_19010	ENOG4108I5W	peptide transport system, permease protein
E4185_19015	ENOG4108EU3	peptide transport system, permease
E4185_19020	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
E4185_19030	ENOG4108JQ2	peptide transport system atp-binding protein
E4185_19035	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
E4185_19040	ENOG4105DDV	Transcriptional regulator (LacI family
E4185_19045	ENOG4105C5Y	PTS System
E4185_19050	ENOG4105CS2	ec 3.2.1.21
E4185_19055	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E4185_19060	ENOG4105E96	Colicin v production protein
E4185_19065	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E4185_19070	ENOG4105D1H	recombination factor protein RarA
E4185_19075	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
E4185_19080	ENOG4105CNU	cell division protein FtsK
E4185_19085	ENOG4105EW9	transcriptional regulator AsnC family
E4185_19090	ENOG4105DCF	alanine dehydrogenase
E4185_19095	ENOG4105C3M	thioredoxin reductase
E4185_19100	ENOG4106TD9	Diguanylate cyclase
E4185_19105	ENOG4107MBR	17 kDa surface antigen
E4185_19110	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
E4185_19115	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
E4185_19120	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E4185_19125	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4185_19130	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
E4185_19135	ENOG4105VEQ	Cold shock protein
E4185_19140	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E4185_19155	ENOG4105DDY	UPF0142 protein ycaO
E4185_19160	ENOG4105TMB	Formate nitrite transporter
E4185_19165	ENOG4105C6N	Formate acetyltransferase
E4185_19170	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
E4185_19180	ENOG4107STF	Involved in phosphonate degradation (By similarity)
E4185_19190	ENOG4105C4Y	ABC transporter
E4185_19200	ENOG4107RCV	ABC transporter, permease
E4185_19205	ENOG4105CJP	fad dependent oxidoreductase
E4185_19230	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
E4185_19235	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
E4185_19240	ENOG4105C7S	Dehydrogenase
E4185_19245	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E4185_19250	ENOG4105E33	succinate dehydrogenase
E4185_19255	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E4185_19260	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
E4185_19265	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
E4185_19270	ENOG4105BZN	citrate synthase
E4185_19285	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4185_19300	ENOG4105CEE	C4-dicarboxylate transporter
E4185_19315	ENOG4108VKG	metal-dependent hydrolase
E4185_19330	ENOG4105NRA	50s ribosomal protein l31 type b
E4185_19335	ENOG4105YK5	50S ribosomal protein L36
E4185_19345	ENOG4105CNN	ABC, transporter
E4185_19355	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
E4185_19360	ENOG4105EF1	ribulokinase
E4185_19370	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
E4185_19375	ENOG4105ETT	transcriptional Regulator, LysR family
E4185_19380	ENOG4105CHM	Aminotransferase
E4185_19400	ENOG4105FF5	Membrane
E4185_19405	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E4185_19410	ENOG4105CJB	Exodeoxyribonuclease I
E4185_19420	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
E4185_19430	ENOG41067MG	lrgb family
E4185_19435	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
E4185_19440	ENOG4108IQE	Amp-dependent synthetase and ligase
E4185_19455	ENOG4105EE5	Membrane protein terC
E4185_19460	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4185_19465	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E4185_19470	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
E4185_19475	ENOG4105C10	Electron transfer flavoprotein
E4185_19480	ENOG4105BZJ	Electron transfer flavoprotein
E4185_19495	ENOG4105QZU	Inner membrane protein YfeZ
E4185_19510	ENOG4105D05	Receptor
E4185_19515	ENOG4105DQ5	transport system permease protein
E4185_19520	ENOG4105TVJ	transport system, permease
E4185_19525	ENOG4105E0A	ABC, transporter
E4185_19530	ENOG4108TSE	Transferase
E4185_19540	ENOG4105C0W	non-ribosomal peptide synthetase
E4185_19550	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
E4185_19560	ENOG4105WQI	isochorismatase
E4185_19565	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
E4185_19575	ENOG4105F3T	(LipO)protein
E4185_19610	ENOG4107RE1	Inosine-guanosine kinase
E4185_19620	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
E4185_19625	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E4185_19630	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E4185_19635	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E4185_19640	ENOG4105F2I	Transposase
E4185_19730	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4185_19750	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4185_19765	ENOG4105F2I	Transposase
E4185_19775	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
E4185_19780	ENOG4107QR9	Iron-sulfur cluster binding protein
E4185_19785	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
E4185_19795	ENOG4105CR8	Transcriptional regulator
E4185_19805	ENOG4105MSB	protein, conserved in bacteria
E4185_19820	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4185_19825	ENOG4107QZM	n-acetylglutamate synthase
E4185_19835	ENOG4105CFH	Aspartokinase
E4185_19845	ENOG4107T7U	Sulfatase
E4185_19850	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
E4185_19855	ENOG4105K8R	UPF0145 protein
E4185_19865	ENOG4105CEP	NADH dehydrogenase
E4185_19870	ENOG4105D0Y	UPF0227 protein
E4185_19875	ENOG4105DPN	Oligoendopeptidase f
E4185_19885	ENOG4105CKW	Inner membrane protein yedI
E4185_19895	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4185_19900	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4185_19940	ENOG4105K59	histidine triad (HIT) protein
E4185_19945	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_19955	ENOG4105CD3	dihydroorotase
E4185_19975	ENOG4105D7V	transposase
E4185_19995	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E4185_20000	ENOG4105DU1	integral membrane protein, terc
E4185_20005	ENOG4108JQ7	(ABC) transporter
E4185_20010	ENOG4105C3U	ABC transporter
E4185_20015	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4185_20020	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4185_20025	ENOG4107QSI	ABC, transporter
E4185_20030	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
E4185_20035	ENOG4105C0A	alcohol dehydrogenase
E4185_20040	ENOG4105CPI	Metal Dependent Phosphohydrolase
E4185_20045	ENOG4108HRK	Histidine kinase
E4185_20050	ENOG4108NEV	two component transcriptional regulator, LytTR family
E4185_20060	ENOG4105EGS	Mechanosensitive ion channel
E4185_20065	ENOG4105KK7	inner membrane protein YiaW
E4185_20070	ENOG4105EFX	secretion protein, HlyD family
E4185_20075	ENOG4105CFI	type iii restriction protein res subunit
E4185_20080	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
E4185_20085	ENOG41090BQ	Glutaredoxin
E4185_20095	ENOG4105CHM	Aminotransferase
E4185_20100	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4185_20105	ENOG4105RKW	reductase (By
E4185_20115	ENOG4107SDU	Methyl-accepting chemotaxis
E4185_20125	ENOG4108PCN	EamA-like transporter family
E4185_20130	ENOG4105DGN	Electron transport complex
E4185_20135	ENOG4108R3D	Electron transport complex
E4185_20140	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
E4185_20145	ENOG4105D6A	Electron transport complex
E4185_20150	ENOG4108UQQ	Electron transport complex
E4185_20160	ENOG4105CSM	endonuclease III
E4185_20165	ENOG4108UYE	Lactoylglutathione lyase
E4185_20180	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E4185_20190	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
E4185_20200	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
E4185_20210	ENOG4105D2T	synthase
E4185_20215	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
E4185_20225	ENOG4108YRB	methyltransferase
E4185_20230	ENOG4105F0R	Cytidylyltransferase
E4185_20235	ENOG4108S0S	Nucleotidyl transferase
E4185_20250	ENOG4105MQ3	flagellar protein FliS
E4185_20265	ENOG4105I03	Flagellin
E4185_20270	ENOG4105I03	Flagellin
E4185_20275	ENOG4105EN6	Membrane
E4185_20285	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E4185_20295	ENOG4108JQB	penicillin-binding protein 1C
E4185_20300	ENOG4105DN3	alpha-2-macroglobulin domain protein
E4185_20310	ENOG410600T	transposase
E4185_20315	ENOG410600T	transposase
E4185_20330	ENOG4105J12	Multidrug resistance protein mdtN
E4185_20345	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4185_20350	ENOG4105BZU	Histidine kinase
E4185_20355	ENOG4105F1A	Pyruvate formate-lyase
E4185_20375	ENOG410600T	transposase
E4185_20405	ENOG4107RGC	Glycosyl transferase, family 2
E4185_20410	ENOG4105E12	capsule polysaccharide
E4185_20415	ENOG41084CK	capsule polysaccharide
E4185_20420	ENOG4106YG3	ABC transporter
E4185_20425	ENOG4105DSP	amino acid AbC transporter
E4185_20430	ENOG4106PMH	Extracellular solute-binding protein family 3
E4185_20435	ENOG4108JEH	abc transporter atp-binding protein
E4185_20440	ENOG4105DWU	Membrane
E4185_20465	ENOG4105DYB	Isoaspartyl dipeptidase
E4185_20475	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
E4185_20480	ENOG4105CI2	imidazolone-5-propionate hydrolase
E4185_20490	ENOG4105K89	arsenate reductase
E4185_20500	ENOG4105ERG	peptidase m48, ste24p
E4185_20525	ENOG4105CSR	polyphosphate kinase 2
E4185_20530	ENOG4108IJ9	(ABC) transporter
E4185_20540	ENOG4105D56	permease protein
E4185_20545	ENOG4107FKK	extracellular solute-binding protein family 1
E4185_20550	ENOG4106V8H	Nucleoid-associated protein
E4185_20555	ENOG4105PAN	UPF0352 protein
E4185_20560	ENOG4105E68	Sulfatase
E4185_20565	ENOG4105D05	Receptor
E4185_20570	ENOG4105CUG	Oligopeptidase b
E4185_20590	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
E4185_20595	ENOG4108WFC	UPF0438 protein yifE
E4185_20610	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4185_20615	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
E4185_20620	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
E4185_20625	ENOG4105E98	transcriptional regulator DeoR family
E4185_20630	ENOG4105CXY	transporter
E4185_20635	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4185_20640	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
E4185_20645	ENOG4105HEI	LysR family (Transcriptional regulator
E4185_20665	ENOG4105CV8	reductase
E4185_20670	ENOG4105F27	Major Facilitator
E4185_20680	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4185_20685	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4185_20690	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E4185_20705	ENOG4105DU6	RNA polymerase
E4185_20720	ENOG4108Q2J	Inner membrane protein YebE
E4185_20740	ENOG4106428	Protein of unknown function (DUF2496)
E4185_20750	ENOG4105JQN	Transcriptional regulator
E4185_20760	ENOG4105DJ2	Major Facilitator Superfamily
E4185_20765	ENOG4105FE9	pseudouridine synthase
E4185_20770	ENOG4105D82	Glutamate dehydrogenase
E4185_20810	ENOG4105BZU	Histidine kinase
E4185_20825	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
E4185_20845	ENOG4105D7V	transposase
E4185_20875	ENOG4108YYC	ycei family
E4185_20880	ENOG4105CC0	LysR family Transcriptional regulator
E4185_20890	ENOG4105CKU	formyltetrahydrofolate synthetase
E4185_20895	ENOG4105C8Q	Methyl-accepting chemotaxis
E4185_20900	ENOG4105EUJ	GTP cyclohydrolase i
E4185_20905	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
E4185_20910	ENOG4105D06	uba thif-type nad fad binding protein
E4185_20915	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
E4185_20920	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
E4185_20925	ENOG4105E0C	molybdate abc transporter
E4185_20930	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
E4185_20935	ENOG4108ZAF	Molybdopterin
E4185_20940	ENOG4105M00	molybdopterin converting factor, subunit 1
E4185_20945	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E4185_20950	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
E4185_20955	ENOG4105CUW	cytochrome C-TYPE protein
E4185_20965	ENOG4105GXZ	Ferredoxin-type protein NapH
E4185_20970	ENOG4108BGM	Quinol dehydrogenase periplasmic component
E4185_20975	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
E4185_20980	ENOG41061Q0	Assembly protein for periplasmic nitrate reductase
E4185_20990	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E4185_20995	ENOG4105BZU	Histidine kinase
E4185_21000	ENOG4105WH1	Two component transcriptional regulator luxr family
E4185_21015	ENOG4105BZU	Histidine kinase
E4185_21025	ENOG4105CHW	UPF0052 protein
E4185_21035	ENOG4105E7A	Glutamine amidotransferase
E4185_21040	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
E4185_21045	ENOG4107QPN	acyl-Coa dehydrogenase
E4185_21055	ENOG410600T	transposase
E4185_21075	ENOG4107RZZ	dna polymerase iii epsilon subunit
E4185_21080	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4185_21085	ENOG4105D1A	Methyltransferase
E4185_21090	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E4185_21095	ENOG4105E9H	Lytic Murein transglycosylase
E4185_21110	ENOG4105NAU	thioesterase Superfamily protein
E4185_21120	ENOG41060NJ	transcriptional regulator
E4185_21125	ENOG4107SC1	transglycosylase
E4185_21130	ENOG4105BZU	Histidine kinase
E4185_21135	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
E4185_21155	ENOG4105MA0	exported protein
E4185_21170	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
E4185_21180	ENOG4107ZN8	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
E4185_21190	ENOG4105VNH	ABC transporter solute-binding protein
E4185_21205	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
E4185_21210	ENOG4105CVE	Lytic murein transglycosylase
E4185_21225	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
E4185_21230	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
E4185_21235	ENOG4105EV9	Alpha Beta Hydrolase
E4185_21245	ENOG4105NNH	LexA regulated protein
E4185_21250	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
E4185_21260	ENOG41090R7	Ferric uptake
E4185_21265	ENOG4105CX6	glutaminyL-tRNA synthetase
E4185_21270	ENOG4105E2D	ec 3.2.1.52
E4185_21275	ENOG4105CI1	PTS System
E4185_21280	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E4185_21285	ENOG4105CE4	GlcNAc 6-P deacetylase
E4185_21290	ENOG4105E2R	ROK family
E4185_21295	ENOG4105DIJ	Phosphoethanolamine transferase
E4185_21300	ENOG4105CDY	transcriptional regulatory protein
E4185_21305	ENOG4105C9M	aspartyl-trna synthetase
E4185_21315	ENOG41081XQ	Conserved Protein
E4185_21320	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
E4185_21325	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
E4185_21345	ENOG4105C5Q	Transcriptional regulator
E4185_21350	ENOG4107TT5	NLP P60 protein
E4185_21360	ENOG4107RGH	Aldehyde dehydrogenase
E4185_21365	ENOG4108RZE	Tetr family transcriptional regulator
E4185_21380	ENOG4105C6T	cysteine synthase
E4185_21400	ENOG4105UQX	Mate efflux family protein
E4185_21410	ENOG4105Z2P	Protein of unknown function (DUF465)
E4185_21420	ENOG4107SQI	penicillin amidase
E4185_21425	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
E4185_21435	ENOG4105QVC	MOSC domain-containing protein
E4185_21435	ENOG4105QVC	MOSC domain-containing protein
E4185_21440	ENOG4105D0M	Protease HtpX homolog
E4185_21450	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E4185_21455	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4185_21460	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E4185_21465	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E4185_21480	ENOG4105C5S	asparaginyl-tRNA synthetase
E4185_21485	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
E4185_21505	ENOG4105KUZ	arsenate reductase
E4185_21510	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E4185_21525	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
E4185_21540	ENOG410829K	Lysine exporter protein (Lyse ygga)
E4185_21550	ENOG4105RX8	Protein of unknown function (DUF1523)
E4185_21565	ENOG4105DU0	nucleoside hydrolase
E4185_21570	ENOG4105D3G	Pseudouridine synthase
E4185_21575	ENOG4107SXA	Phosphorylase
E4185_21580	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4185_21585	ENOG4105K4T	epimerase
E4185_21590	ENOG4105VDB	UPF0125 protein
E4185_21595	ENOG4108Z1B	Cyclase dehydrase
E4185_21600	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E4185_21790	ENOG4105NY2	NinB protein
E4185_21815	ENOG4105NI8	Cytosine-specific methyltransferase
E4185_21830	ENOG4108ZUE	Phage regulatory protein rha
E4185_21865	ENOG41076J9	exonuclease VIII
E4185_21955	ENOG4108C33	Resolvase
E4185_21960	ENOG4106BHJ	Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non- cognate toxin LsoA
E4185_21965	ENOG4106K8T	Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA
E4185_21970	ENOG4105D5G	Transposase
E4185_21975	ENOG4105DFP	Integrase
E4185_21990	ENOG4105NI8	Cytosine-specific methyltransferase
E4185_22010	ENOG4108YYD	acetyltransferase
E4185_22045	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E4185_22055	ENOG41065U4	response regulator
E4185_22070	ENOG4108JJ9	ABC, transporter
E4185_22075	ENOG4108JJ8	(ABC) transporter
E4185_22095	ENOG4108R96	Methyltransferase, YaeB family
E4185_22115	ENOG4105C6T	cysteine synthase
E4185_22120	ENOG4105KZ7	phosphocarrier protein hpr
E4185_22125	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
E4185_22130	ENOG4105C5Y	PTS System
E4185_22135	ENOG4108VKM	cytochrome b561
E4185_22140	ENOG4105EYH	Exonuclease
E4185_22145	ENOG4107RH8	nuclease SbcCD subunit D
E4185_22150	ENOG4105K5X	acetyltransferase
E4185_22155	ENOG4105DH7	May be involved in recombination (By similarity)
E4185_22160	ENOG4108UJV	acyl-CoA thioesterase i
E4185_22175	ENOG4105CJP	fad dependent oxidoreductase
E4185_22180	ENOG4107VRI	Transcriptional regulator
E4185_22185	ENOG4105C26	Dehydrogenase
E4185_22195	ENOG4105CUB	amino acid
E4185_22200	ENOG4105CUB	amino acid
E4185_22215	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4185_22220	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
E4185_22225	ENOG4105BZU	Histidine kinase
E4185_22230	ENOG4105XIQ	Protein of unknown function (DUF2517)
E4185_22260	ENOG4105EQ2	LysR family Transcriptional regulator
E4185_22265	ENOG4105ENX	hydrolase
E4185_22275	ENOG4107RTG	Major Facilitator superfamily
E4185_22300	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)