locus-tag	class	description
E4185_00080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4185_00090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4185_00105	COG4263	nitrous-oxide reductase activity
E4185_00110	COG3901	Regulator of nitric oxide reductase transcription
E4185_00110	COG0348	domain, Protein
E4185_00125	COG1388	LysM domain
E4185_00125	COG1376	ErfK ybiS ycfS ynhG family protein
E4185_00140	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4185_00145	COG0791	NLP P60 protein
E4185_00155	COG3118	belongs to the thioredoxin family
E4185_00165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4185_00170	COG0788	formyltetrahydrofolate deformylase activity
E4185_00195	COG0739	heme binding
E4185_00195	COG1196	nuclear chromosome segregation
E4185_00195	COG0741	lytic transglycosylase activity
E4185_00200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4185_00205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4185_00210	COG0673	inositol 2-dehydrogenase activity
E4185_00225	COG5433	transposase activity
E4185_00240	COG1032	radical SAM domain protein
E4185_00245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_00255	COG3706	GGDEF domain
E4185_00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4185_00265	COG0733	neurotransmitter:sodium symporter activity
E4185_00295	COG0281	malic enzyme
E4185_00320	COG2233	PERMEase
E4185_00325	COG0095	Lipoate-protein ligase
E4185_00330	COG1115	amino acid carrier protein
E4185_00335	COG0019	diaminopimelate decarboxylase activity
E4185_00345	COG0678	peroxiredoxin activity
E4185_00350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4185_00360	COG1126	abc transporter atp-binding protein
E4185_00365	COG0765	amino acid transport
E4185_00370	COG4597	amino acid ABC transporter
E4185_00375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_00390	COG1131	(ABC) transporter
E4185_00395	COG0545	Peptidyl-prolyl cis-trans isomerase
E4185_00410	COG3142	Participates in the control of copper homeostasis
E4185_00440	COG0745	RESPONSE REGULATOR receiver
E4185_00445	COG0346	lactoylglutathione lyase activity
E4185_00455	COG3284	Transcriptional regulator
E4185_00460	COG1012	belongs to the aldehyde dehydrogenase family
E4185_00470	COG0697	spore germination
E4185_00480	COG3290	protein histidine kinase activity
E4185_00500	COG1566	PFAM secretion protein HlyD family protein
E4185_00525	COG0602	queuosine metabolic process
E4185_00530	COG1328	CTP reductase activity
E4185_00540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4185_00545	COG3115	cell septum assembly
E4185_00560	COG2860	membrane
E4185_00570	COG3108	Peptidase M15
E4185_00575	COG2989	Protein conserved in bacteria
E4185_00590	COG0463	Glycosyl transferase, family 2
E4185_00605	COG0366	Alpha amylase catalytic
E4185_00650	COG3706	GGDEF domain
E4185_00655	COG0037	tRNA processing
E4185_00660	COG3590	peptidase
E4185_00670	COG0488	(ABC) transporter
E4185_00675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4185_00680	COG0531	amino acid
E4185_00685	COG0814	amino acid
E4185_00690	COG0583	DNA-binding transcription factor activity
E4185_00700	COG0825	malonyl-CoA metabolic process
E4185_00710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4185_00715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4185_00720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4185_00725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4185_00730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4185_00745	COG0750	zinc metalloprotease
E4185_00750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4185_00755	COG0575	Belongs to the CDS family
E4185_00760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4185_00765	COG0233	cytoplasmic translational termination
E4185_00770	COG0528	UMP kinase activity
E4185_00775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4185_00780	COG0052	Belongs to the universal ribosomal protein uS2 family
E4185_00785	COG0024	Methionine aminopeptidase
E4185_00790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4185_00795	COG2171	N-acyltransferase activity
E4185_00805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4185_00805	COG1263	PTS System
E4185_00815	COG4580	involved in the transport of maltose and maltodextrins
E4185_00825	COG0564	pseudouridine synthase activity
E4185_00830	COG3098	single-species biofilm formation
E4185_00855	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4185_00865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4185_00865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4185_00875	COG3706	GGDEF domain
E4185_00880	COG1611	Belongs to the LOG family
E4185_00885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4185_00890	COG0473	3-isopropylmalate dehydrogenase activity
E4185_00900	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4185_00905	COG2363	Small membrane protein
E4185_00915	COG0583	DNA-binding transcription factor activity
E4185_00920	COG0840	transmembrane signaling receptor activity
E4185_00925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4185_00940	COG1477	protein flavinylation
E4185_00945	COG2871	sodium ion transport
E4185_00950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4185_00955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4185_00960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4185_00965	COG1805	sodium ion transport
E4185_00970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4185_00975	COG0271	Belongs to the BolA IbaG family
E4185_00980	COG2813	Specifically methylates the guanine in position
E4185_00990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4185_01000	COG2211	Major facilitator Superfamily
E4185_01005	COG3248	Nucleoside-binding outer membrane protein
E4185_01010	COG1666	GTP binding
E4185_01015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4185_01025	COG0659	secondary active sulfate transmembrane transporter activity
E4185_01055	COG1393	Belongs to the ArsC family
E4185_01060	COG0798	PFAM Bile acid sodium symporter
E4185_01070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4185_01110	COG3718	enzyme involved in inositol metabolism
E4185_01125	COG0673	inositol 2-dehydrogenase activity
E4185_01130	COG2176	DNA-directed DNA polymerase activity
E4185_01140	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4185_01145	COG0673	inositol 2-dehydrogenase activity
E4185_01150	COG3962	Belongs to the TPP enzyme family
E4185_01200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_01200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4185_01200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_01205	COG0383	alpha-mannosidase activity
E4185_01210	COG3039	Transposase
E4185_01230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4185_01235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4185_01240	COG1151	hydroxylamine reductase activity
E4185_01245	COG0783	Belongs to the Dps family
E4185_01270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4185_01285	COG0300	oxidoreductase activity
E4185_01295	COG0415	Belongs to the DNA photolyase family
E4185_01300	COG0789	Transcriptional regulator
E4185_01305	COG3272	Protein of unknown function (DUF1722)
E4185_01330	COG1605	Chorismate mutase
E4185_01330	COG0077	Prephenate dehydratase
E4185_01355	COG3302	dmso reductase anchor subunit
E4185_01360	COG0437	4 iron, 4 sulfur cluster binding
E4185_01405	COG1349	DNA-binding transcription factor activity
E4185_01410	COG2084	Dehydrogenase
E4185_01415	COG3395	kinase activity
E4185_01420	COG0235	Class ii aldolase
E4185_01425	COG3622	Belongs to the hyi family
E4185_01430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4185_01435	COG2610	gluconate transmembrane transporter activity
E4185_01455	COG0300	oxidoreductase activity
E4185_01480	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4185_01500	COG3813	Protein conserved in bacteria
E4185_01510	COG0826	peptidase U32
E4185_01515	COG1280	lysine exporter protein (LysE YggA)
E4185_01550	COG2199	diguanylate cyclase activity
E4185_01550	COG2200	EAL domain
E4185_01550	COG2203	Gaf domain
E4185_01590	COG0114	fumarate hydratase activity
E4185_01600	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4185_01600	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4185_01600	COG0506	proline dehydrogenase activity
E4185_01605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4185_01625	COG0737	Belongs to the 5'-nucleotidase family
E4185_01650	COG0545	Peptidyl-prolyl cis-trans isomerase
E4185_01665	COG1047	Peptidyl-prolyl cis-trans
E4185_01670	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4185_01680	COG0835	chemotaxis
E4185_01680	COG0784	Response regulator, receiver
E4185_01685	COG0429	hydrolase of the alpha beta-hydrolase fold
E4185_01690	COG5001	Diguanylate cyclase
E4185_01690	COG2203	Gaf domain
E4185_01690	COG4251	negative regulation of phosphorylation
E4185_01690	COG3706	GGDEF domain
E4185_01695	COG3089	Belongs to the UPF0270 family
E4185_01700	COG3954	Phosphoribulokinase
E4185_01715	COG1765	OsmC-like protein
E4185_01745	COG2205	protein histidine kinase activity
E4185_01750	COG2814	Major facilitator Superfamily
E4185_01775	COG0748	coenzyme F420 binding
E4185_01780	COG3721	Heme iron utilization protein
E4185_01790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4185_01815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4185_01830	COG0741	lytic transglycosylase activity
E4185_01835	COG0488	(ABC) transporter
E4185_01845	COG2252	PERMEase
E4185_01850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4185_01855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4185_01860	COG3178	'Phosphotransferase
E4185_01865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4185_01875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4185_01880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4185_01885	COG2967	ApaG domain
E4185_01890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4185_01900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4185_01915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4185_01920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4185_01925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4185_01930	COG0142	geranyltranstransferase activity
E4185_01935	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4185_01940	COG0330	HflC and HflK could
E4185_01945	COG0330	HflC and HflK could
E4185_01950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4185_01955	COG1923	regulation of RNA biosynthetic process
E4185_01960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4185_01965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4185_01975	COG0802	atpase or kinase
E4185_01980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4185_01980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4185_02000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4185_02005	COG2011	ABC-type metal ion transport system permease component
E4185_02010	COG1464	Belongs to the NlpA lipoprotein family
E4185_02020	COG0840	transmembrane signaling receptor activity
E4185_02050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4185_02055	COG0784	Response regulator, receiver
E4185_02055	COG5002	protein histidine kinase activity
E4185_02055	COG2198	Histidine kinase
E4185_02090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4185_02095	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4185_02105	COG2716	regulation of RNA biosynthetic process
E4185_02110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4185_02115	COG3013	Belongs to the UPF0304 family
E4185_02120	COG3092	negative regulation of chromosome organization
E4185_02125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4185_02130	COG0280	phosphate acetyltransferase
E4185_02130	COG0857	belongs to the CobB CobQ family
E4185_02135	COG0440	acetolactate synthase activity
E4185_02140	COG0028	Belongs to the TPP enzyme family
E4185_02150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4185_02155	COG0671	phosphoesterase, PA-phosphatase related
E4185_02165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4185_02175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4185_02180	COG0066	3-isopropylmalate dehydratase activity
E4185_02195	COG4143	(ABC) transporter
E4185_02200	COG1178	ABC-type Fe3 transport system permease component
E4185_02205	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4185_02215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4185_02285	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4185_02295	COG3706	GGDEF domain
E4185_02300	COG0513	Belongs to the DEAD box helicase family
E4185_02320	COG0154	amidase activity
E4185_02325	COG2957	Belongs to the agmatine deiminase family
E4185_02345	COG1902	pentaerythritol trinitrate reductase activity
E4185_02365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4185_02380	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4185_02395	COG0456	acetyltransferase
E4185_02405	COG1022	Amp-dependent synthetase and ligase
E4185_02415	COG1794	racemase activity, acting on amino acids and derivatives
E4185_02430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4185_02445	COG0733	neurotransmitter:sodium symporter activity
E4185_02450	COG0733	neurotransmitter:sodium symporter activity
E4185_02465	COG0561	phosphatase activity
E4185_02495	COG1846	Transcriptional regulator
E4185_02500	COG2130	NADP-dependent
E4185_02525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4185_02530	COG1640	4-alpha-glucanotransferase
E4185_02535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4185_02545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4185_02620	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4185_02625	COG2885	chlorophyll binding
E4185_02630	COG0823	Involved in the tonB-independent uptake of proteins
E4185_02645	COG0811	peptide transport
E4185_02650	COG0824	Thioesterase
E4185_02655	COG3790	cyd operon protein YbgE
E4185_02660	COG4890	Cyd operon protein YbgT
E4185_02665	COG1294	oxidase, subunit
E4185_02670	COG1271	oxidase subunit
E4185_02675	COG2255	four-way junction helicase activity
E4185_02680	COG0632	four-way junction helicase activity
E4185_02685	COG0442	prolyl-tRNA aminoacylation
E4185_02690	COG4221	oxidoreductase activity
E4185_02705	COG1024	Enoyl-CoA hydratase
E4185_02715	COG0110	maltose O-acetyltransferase activity
E4185_02725	COG4166	transmembrane transport
E4185_02735	COG0840	transmembrane signaling receptor activity
E4185_02755	COG0513	Belongs to the DEAD box helicase family
E4185_02760	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4185_02800	COG1448	Aminotransferase
E4185_02815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4185_02820	COG1328	CTP reductase activity
E4185_02850	COG0840	transmembrane signaling receptor activity
E4185_02855	COG3397	chitin binding
E4185_02865	COG0583	DNA-binding transcription factor activity
E4185_02870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4185_02875	COG4208	sulfate ABC transporter
E4185_02890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4185_02925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4185_02930	COG0564	pseudouridine synthase activity
E4185_02950	COG0459	protein refolding
E4185_02955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4185_02960	COG0534	Mate efflux family protein
E4185_02965	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4185_02970	COG1027	Aspartate ammonia-lyase
E4185_02975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4185_02980	COG2918	glutathione biosynthetic process
E4185_02985	COG0612	Peptidase, M16
E4185_02990	COG1238	metal cluster binding
E4185_02995	COG1064	alcohol dehydrogenase
E4185_03030	COG0359	binds to the 23S rRNA
E4185_03035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4185_03040	COG0360	Binds together with S18 to 16S ribosomal RNA
E4185_03045	COG1914	H( )-stimulated, divalent metal cation uptake system
E4185_03060	COG2153	protein acetylation
E4185_03070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4185_03075	COG0557	exoribonuclease II activity
E4185_03080	COG3706	GGDEF domain
E4185_03085	COG3385	transposase activity
E4185_03090	COG1854	S-ribosylhomocysteine lyase activity
E4185_03105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4185_03105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4185_03135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4185_03140	COG1047	Peptidyl-prolyl cis-trans
E4185_03145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4185_03150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4185_03155	COG0196	riboflavin kinase activity
E4185_03160	COG0728	peptidoglycan biosynthetic process
E4185_03165	COG0268	Binds directly to 16S ribosomal RNA
E4185_03170	COG0640	Transcriptional regulator
E4185_03175	COG0583	DNA-binding transcription factor activity
E4185_03185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4185_03190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4185_03195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4185_03205	COG1051	belongs to the nudix hydrolase family
E4185_03220	COG0335	large ribosomal subunit rRNA binding
E4185_03225	COG0336	Belongs to the RNA methyltransferase TrmD family
E4185_03230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4185_03235	COG0228	four-way junction DNA binding
E4185_03240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4185_03245	COG4137	Cytochrome C assembly protein
E4185_03250	COG4536	flavin adenine dinucleotide binding
E4185_03260	COG1017	nitric oxide dioxygenase activity
E4185_03260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4185_03265	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4185_03270	COG0039	L-malate dehydrogenase activity
E4185_03275	COG4160	amino acid transport
E4185_03280	COG4215	(ABC) transporter
E4185_03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_03290	COG1126	abc transporter atp-binding protein
E4185_03295	COG1438	arginine binding
E4185_03300	COG2837	iron assimilation
E4185_03315	COG1840	ABC-type Fe3 transport system, periplasmic component
E4185_03320	COG0347	Belongs to the P(II) protein family
E4185_03335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4185_03340	COG0583	DNA-binding transcription factor activity
E4185_03355	COG1929	Belongs to the glycerate kinase type-1 family
E4185_03360	COG2610	gluconate transmembrane transporter activity
E4185_03365	COG3835	regulator
E4185_03370	COG3112	Uncharacterised protein family (UPF0231)
E4185_03390	COG1872	DUF167
E4185_03395	COG0762	integral membrane protein
E4185_03400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4185_03405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4185_03420	COG3022	response to hydroperoxide
E4185_03425	COG0513	Belongs to the DEAD box helicase family
E4185_03430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4185_03450	COG0735	belongs to the Fur family
E4185_03455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4185_03470	COG0776	regulation of translation
E4185_03475	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4185_03485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4185_03500	COG0560	Phosphoserine phosphatase
E4185_03510	COG3064	Membrane
E4185_03525	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4185_03530	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4185_03535	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4185_03545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4185_03550	COG0084	hydrolase, TatD family'
E4185_03570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4185_03575	COG0004	ammonium transporteR
E4185_03585	COG3039	Transposase
E4185_03595	COG0582	viral genome integration into host DNA
E4185_03600	COG4974	Belongs to the 'phage' integrase family
E4185_03610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4185_03700	COG4695	Portal protein
E4185_03845	COG0795	lipopolysaccharide-transporting ATPase activity
E4185_03850	COG0795	lipopolysaccharide-transporting ATPase activity
E4185_03855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4185_03860	COG2927	DNA polymerase III (CHI subunit)
E4185_03870	COG1253	flavin adenine dinucleotide binding
E4185_03875	COG0586	Pfam SNARE associated Golgi protein
E4185_03880	COG1686	Belongs to the peptidase S11 family
E4185_03915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4185_03920	COG0527	aspartate kinase activity
E4185_03925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4185_03930	COG2137	regulation of response to DNA damage stimulus
E4185_03935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4185_03940	COG1546	Belongs to the CinA family
E4185_03950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4185_03970	COG3068	Protein conserved in bacteria
E4185_03980	COG0739	heme binding
E4185_04000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4185_04005	COG1121	(ABC) transporter
E4185_04010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4185_04015	COG0583	DNA-binding transcription factor activity
E4185_04025	COG1573	uracil-dna glycosylase
E4185_04035	COG2827	Endonuclease containing a URI domain
E4185_04050	COG1842	Phage shock protein A
E4185_04055	COG0204	Acyl-transferase
E4185_04075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4185_04145	COG1051	belongs to the nudix hydrolase family
E4185_04150	COG3150	esterase
E4185_04160	COG3151	Protein conserved in bacteria
E4185_04165	COG0494	nUDIX hydrolase
E4185_04170	COG1538	Outer membrane efflux protein
E4185_04175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4185_04175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4185_04180	COG1560	Kdo2-lipid A biosynthetic process
E4185_04195	COG2771	luxR family
E4185_04215	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4185_04220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_04220	COG2213	PTS system mannitol-specific
E4185_04225	COG0246	Mannitol dehydrogenase
E4185_04230	COG3722	fumarate hydratase activity
E4185_04255	COG1671	Belongs to the UPF0178 family
E4185_04270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4185_04275	COG0513	Belongs to the DEAD box helicase family
E4185_04300	COG1575	Belongs to the MenA family. Type 1 subfamily
E4185_04310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4185_04315	COG0596	Alpha beta hydrolase
E4185_04320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4185_04325	COG1441	menaquinone biosynthetic process
E4185_04335	COG3291	Pkd domain containing protein
E4185_04340	COG2949	membrane
E4185_04345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4185_04355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4185_04385	COG2873	o-acetylhomoserine
E4185_04395	COG1979	alcohol dehydrogenase
E4185_04410	COG4221	oxidoreductase activity
E4185_04445	COG1368	sulfuric ester hydrolase activity
E4185_04470	COG3047	cAMP biosynthetic process
E4185_04475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4185_04480	COG2197	response regulator
E4185_04505	COG1278	Cold shock
E4185_04510	COG2205	protein histidine kinase activity
E4185_04515	COG0745	RESPONSE REGULATOR receiver
E4185_04535	COG3706	GGDEF domain
E4185_04540	COG0347	Belongs to the P(II) protein family
E4185_04545	COG0004	ammonium transporteR
E4185_04555	COG0346	lactoylglutathione lyase activity
E4185_04575	COG1074	ATP-dependent DNA helicase activity
E4185_04580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4185_04585	COG2259	Doxx family
E4185_04590	COG1741	Belongs to the pirin family
E4185_04600	COG0583	DNA-binding transcription factor activity
E4185_04625	COG1175	transmembrane transport
E4185_04635	COG3842	ATPase activity
E4185_04645	COG2203	Gaf domain
E4185_04645	COG2199	diguanylate cyclase activity
E4185_04660	COG2207	Transcriptional regulator
E4185_04665	COG0454	-acetyltransferase
E4185_04665	COG0456	acetyltransferase
E4185_04670	COG0753	catalase activity
E4185_04695	COG0628	permease
E4185_04710	COG2957	Belongs to the agmatine deiminase family
E4185_04720	COG2957	Belongs to the agmatine deiminase family
E4185_04725	COG0583	DNA-binding transcription factor activity
E4185_04730	COG3284	Transcriptional regulator
E4185_04740	COG1461	Dihydroxyacetone kinase
E4185_04745	COG2376	Dihydroxyacetone kinase
E4185_04750	COG2252	PERMEase
E4185_04755	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4185_04790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4185_04795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4185_04800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4185_04805	COG0049	tRNA binding
E4185_04810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4185_04815	COG2168	tRNA wobble position uridine thiolation
E4185_04835	COG2964	Protein conserved in bacteria
E4185_04840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4185_04845	COG0085	RNA polymerase activity
E4185_04850	COG0222	ribosome binding
E4185_04855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4185_04860	COG0081	regulation of translation
E4185_04865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4185_04870	COG0250	Participates in transcription elongation, termination and antitermination
E4185_04885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4185_04910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4185_04915	COG0569	domain protein
E4185_04920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4185_04930	COG3005	denitrification pathway
E4185_04950	COG0745	RESPONSE REGULATOR receiver
E4185_04965	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4185_04985	COG2204	response regulator
E4185_04995	COG2205	protein histidine kinase activity
E4185_05015	COG0516	GMP reductase activity
E4185_05015	COG0517	IMP dehydrogenase activity
E4185_05030	COG1522	sequence-specific DNA binding
E4185_05035	COG2502	aspartate--ammonia ligase
E4185_05040	COG0542	response to heat
E4185_05050	COG0564	pseudouridine synthase activity
E4185_05055	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4185_05060	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4185_05070	COG3681	Belongs to the UPF0597 family
E4185_05075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4185_05080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4185_05085	COG1979	alcohol dehydrogenase
E4185_05090	COG2207	Transcriptional regulator
E4185_05095	COG3040	lipid binding
E4185_05110	COG0688	phosphatidylethanolamine metabolic process
E4185_05125	COG0540	Belongs to the ATCase OTCase family
E4185_05130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4185_05135	COG1438	arginine binding
E4185_05140	COG1288	antiporter activity
E4185_05145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4185_05175	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4185_05190	COG3250	beta-galactosidase activity
E4185_05195	COG1609	Transcriptional regulator
E4185_05210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4185_05215	COG2017	converts alpha-aldose to the beta-anomer
E4185_05220	COG0667	Aldo Keto reductase
E4185_05225	COG1968	undecaprenyl-diphosphatase activity
E4185_05230	COG3806	Anti-sigma factor
E4185_05235	COG1595	DNA-templated transcription, initiation
E4185_05245	COG0018	arginyl-trna synthetase
E4185_05255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4185_05260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4185_05280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_05285	COG1131	(ABC) transporter
E4185_05290	COG0842	Transport permease protein
E4185_05295	COG0842	Transport permease protein
E4185_05300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4185_05310	COG2116	formate transmembrane transporter activity
E4185_05315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4185_05315	COG1648	precorrin-2 dehydrogenase activity
E4185_05320	COG2239	Acts as a magnesium transporter
E4185_05325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4185_05330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4185_05340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4185_05350	COG0514	ATP-dependent DNA helicase (RecQ)
E4185_05355	COG0514	ATP-dependent DNA helicase (RecQ)
E4185_05360	COG2050	protein possibly involved in aromatic compounds catabolism
E4185_05380	COG2258	MOSC domain
E4185_05385	COG1177	transmembrane transport
E4185_05390	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4185_05395	COG3842	ATPase activity
E4185_05415	COG0174	glutamine synthetase
E4185_05435	COG3045	CreA protein
E4185_05440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4185_05445	COG0443	Heat shock 70 kDa protein
E4185_05460	COG0366	Alpha amylase catalytic
E4185_05475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4185_05480	COG0745	RESPONSE REGULATOR receiver
E4185_05485	COG2205	protein histidine kinase activity
E4185_05495	COG0281	malic enzyme
E4185_05500	COG0702	epimerase
E4185_05505	COG0254	rRNA binding
E4185_05510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4185_05530	COG0129	dihydroxy-acid dehydratase activity
E4185_05540	COG3978	acetolactate synthase activity
E4185_05555	COG0606	chelatase, subunit chli
E4185_05560	COG0204	Acyl-transferase
E4185_05565	COG0204	Acyl-transferase
E4185_05570	COG1683	Conserved Protein
E4185_05580	COG1335	isochorismatase
E4185_05590	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4185_05595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4185_05600	COG3639	organic phosphonate transmembrane transporter activity
E4185_05605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4185_05610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4185_05620	COG3084	Protein conserved in bacteria
E4185_05625	COG2203	Gaf domain
E4185_05625	COG5001	Diguanylate cyclase
E4185_05625	COG4251	negative regulation of phosphorylation
E4185_05625	COG3706	GGDEF domain
E4185_05630	COG0789	Transcriptional regulator
E4185_05640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4185_05645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4185_05650	COG1561	YicC-like family, N-terminal region
E4185_05660	COG1519	Transferase
E4185_05665	COG0859	PFAM glycosyl transferase family 9
E4185_05670	COG0463	Glycosyl transferase, family 2
E4185_05675	COG0859	PFAM glycosyl transferase family 9
E4185_05680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4185_05685	COG2990	Protein conserved in bacteria
E4185_05690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4185_05700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4185_05705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4185_05715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4185_05725	COG3039	Transposase
E4185_05735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_05745	COG3039	Transposase
E4185_05750	COG0756	dUTP diphosphatase activity
E4185_05760	COG1309	transcriptional regulator
E4185_05765	COG0668	transmembrane transport
E4185_05775	COG0166	Belongs to the GPI family
E4185_05780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4185_05785	COG0583	DNA-binding transcription factor activity
E4185_05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4185_05795	COG1042	CoA-binding domain protein
E4185_05795	COG0045	succinate-CoA ligase (ADP-forming) activity
E4185_05825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4185_05830	COG4206	TonB-dependent receptor
E4185_05835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4185_05840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4185_05845	COG2223	nitrite transmembrane transporter activity
E4185_05850	COG3279	Response regulator of the LytR AlgR family
E4185_05855	COG3275	phosphorelay sensor kinase activity
E4185_05865	COG2223	nitrite transmembrane transporter activity
E4185_05870	COG2081	HI0933 family
E4185_05875	COG1528	Iron-storage protein
E4185_05880	COG3706	GGDEF domain
E4185_05885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4185_05890	COG0589	response to stress
E4185_05930	COG3642	lipopolysaccharide core region biosynthetic process
E4185_05935	COG0859	PFAM glycosyl transferase family 9
E4185_05950	COG1758	RNA polymerase activity
E4185_05955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4185_05960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4185_05965	COG2267	carboxylic ester hydrolase activity
E4185_05975	COG0561	phosphatase activity
E4185_06005	COG1309	transcriptional regulator
E4185_06010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_06015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_06020	COG4191	Histidine kinase
E4185_06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4185_06035	COG0604	alcohol dehydrogenase
E4185_06040	COG2267	carboxylic ester hydrolase activity
E4185_06045	COG1733	regulation of RNA biosynthetic process
E4185_06070	COG2205	protein histidine kinase activity
E4185_06075	COG0745	RESPONSE REGULATOR receiver
E4185_06080	COG2814	Major facilitator Superfamily
E4185_06100	COG0071	Belongs to the small heat shock protein (HSP20) family
E4185_06105	COG0071	Belongs to the small heat shock protein (HSP20) family
E4185_06110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4185_06120	COG2378	regulation of single-species biofilm formation
E4185_06130	COG0187	DNA topoisomerase II activity
E4185_06140	COG0592	DNA-directed DNA polymerase activity
E4185_06145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4185_06165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4185_06170	COG0594	ribonuclease P activity
E4185_06175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4185_06180	COG0706	membrane insertase activity
E4185_06185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4185_06195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4185_06200	COG1120	ATPase activity
E4185_06205	COG4615	Cyclic peptide transporter
E4185_06210	COG4774	siderophore transport
E4185_06215	COG0716	FMN binding
E4185_06220	COG0445	tRNA wobble uridine modification
E4185_06225	COG0357	Ribosomal RNA small subunit methyltransferase G
E4185_06230	COG1192	Involved in chromosome partitioning
E4185_06235	COG1475	DNA binding
E4185_06245	COG0356	it plays a direct role in the translocation of protons across the membrane
E4185_06255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4185_06260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4185_06265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4185_06270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4185_06275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4185_06280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4185_06285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4185_06290	COG4452	Inner membrane protein CreD
E4185_06300	COG2205	protein histidine kinase activity
E4185_06305	COG0745	RESPONSE REGULATOR receiver
E4185_06310	COG1349	DNA-binding transcription factor activity
E4185_06315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4185_06325	COG3039	Transposase
E4185_06335	COG2771	luxR family
E4185_06345	COG0811	peptide transport
E4185_06350	COG0811	peptide transport
E4185_06355	COG0848	biopolymer transport protein
E4185_06360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4185_06395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4185_06400	COG0402	S-adenosylhomocysteine deaminase activity
E4185_06405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4185_06410	COG2226	methyltransferase
E4185_06415	COG3165	ubiquinone biosynthetic process from chorismate
E4185_06420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4185_06425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4185_06430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4185_06435	COG0805	protein transport
E4185_06440	COG0084	hydrolase, TatD family'
E4185_06460	COG0742	ribosomal rna small subunit methyltransferase
E4185_06475	COG0248	Ppx GppA phosphatase
E4185_06480	COG0513	Belongs to the DEAD box helicase family
E4185_06485	COG3118	belongs to the thioredoxin family
E4185_06500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4185_06510	COG2960	long-chain fatty acid transporting porin activity
E4185_06525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4185_06565	COG1609	Transcriptional regulator
E4185_06570	COG3604	Transcriptional regulator
E4185_06575	COG1773	rubredoxin
E4185_06575	COG0426	domain, Protein
E4185_06580	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4185_06590	COG0348	domain, Protein
E4185_06600	COG3033	Beta-eliminating lyase
E4185_06605	COG0814	amino acid
E4185_06620	COG3039	Transposase
E4185_06650	COG0751	glycine-tRNA ligase activity
E4185_06655	COG0752	glycyl-tRNA synthetase alpha subunit
E4185_06660	COG2818	Glycosylase
E4185_06690	COG2885	chlorophyll binding
E4185_06695	COG0251	oxidation-reduction process
E4185_06700	COG0425	Belongs to the sulfur carrier protein TusA family
E4185_06725	COG0745	RESPONSE REGULATOR receiver
E4185_06730	COG0183	Belongs to the thiolase family
E4185_06735	COG1024	Enoyl-CoA hydratase
E4185_06735	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4185_06740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4185_06745	COG0006	proline dipeptidase activity
E4185_06750	COG1739	Uncharacterized protein family UPF0029
E4185_06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4185_06760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4185_06790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4185_06795	COG2166	iron-sulfur cluster assembly
E4185_06800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4185_06805	COG0210	DNA helicase
E4185_06810	COG5001	Diguanylate cyclase
E4185_06810	COG3300	MHYT domain
E4185_06820	COG1063	alcohol dehydrogenase
E4185_06835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4185_06840	COG0438	transferase activity, transferring glycosyl groups
E4185_06845	COG3307	-O-antigen
E4185_06860	COG0604	alcohol dehydrogenase
E4185_06875	COG1580	Controls the rotational direction of flagella during chemotaxis
E4185_06880	COG3161	chorismate lyase activity
E4185_06885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4185_06895	COG2937	Belongs to the GPAT DAPAT family
E4185_06900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4185_06915	COG0534	Mate efflux family protein
E4185_06920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4185_06925	COG2205	protein histidine kinase activity
E4185_06930	COG0745	RESPONSE REGULATOR receiver
E4185_06940	COG1045	serine acetyltransferase
E4185_06950	COG3074	FtsZ-dependent cytokinesis
E4185_06955	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4185_06965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4185_06965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4185_06970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4185_07010	COG1609	Transcriptional regulator
E4185_07015	COG3250	beta-galactosidase activity
E4185_07020	COG2731	YhcH YjgK YiaL family protein
E4185_07025	COG0531	amino acid
E4185_07030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4185_07035	COG0531	amino acid
E4185_07040	COG0385	Bile acid
E4185_07045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4185_07065	COG0583	DNA-binding transcription factor activity
E4185_07095	COG0210	DNA helicase
E4185_07130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4185_07165	COG2391	methyltransferase activity
E4185_07170	COG1280	lysine exporter protein (LysE YggA)
E4185_07180	COG2962	Rard protein
E4185_07190	COG1012	belongs to the aldehyde dehydrogenase family
E4185_07195	COG1396	sequence-specific DNA binding
E4185_07210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4185_07210	COG0519	Catalyzes the synthesis of GMP from XMP
E4185_07220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4185_07240	COG1322	Protein conserved in bacteria
E4185_07245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4185_07250	COG0569	domain protein
E4185_07255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4185_07255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4185_07260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4185_07265	COG0242	peptide deformylase activity
E4185_07275	COG0758	DNA mediated transformation
E4185_07280	COG2922	Belongs to the Smg family
E4185_07285	COG0551	DNA topoisomerase type I activity
E4185_07290	COG0009	L-threonylcarbamoyladenylate synthase
E4185_07295	COG0408	coproporphyrinogen oxidase activity
E4185_07300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4185_07305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4185_07315	COG3078	GTPase activator activity
E4185_07325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4185_07330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4185_07340	COG3852	Histidine kinase
E4185_07350	COG0174	glutamine synthetase
E4185_07360	COG1295	ribonuclease BN
E4185_07365	COG1490	D-aminoacyl-tRNA deacylase activity
E4185_07375	COG0456	acetyltransferase
E4185_07385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4185_07395	COG2610	gluconate transmembrane transporter activity
E4185_07400	COG3265	gluconokinase activity
E4185_07405	COG0129	dihydroxy-acid dehydratase activity
E4185_07410	COG0800	Aldolase
E4185_07415	COG1609	Transcriptional regulator
E4185_07425	COG4942	peptidase
E4185_07430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4185_07435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4185_07440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4185_07445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4185_07450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4185_07450	COG0316	Belongs to the HesB IscA family
E4185_07455	COG1040	competence protein
E4185_07460	COG0596	Alpha beta hydrolase
E4185_07475	COG2183	response to ionizing radiation
E4185_07480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4185_07485	COG0745	RESPONSE REGULATOR receiver
E4185_07490	COG2205	protein histidine kinase activity
E4185_07500	COG0051	transcription antitermination factor activity, RNA binding
E4185_07505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4185_07510	COG0088	Forms part of the polypeptide exit tunnel
E4185_07515	COG0089	rRNA binding
E4185_07520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4185_07525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4185_07530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4185_07535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4185_07540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4185_07545	COG0255	Belongs to the universal ribosomal protein uL29 family
E4185_07550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4185_07555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4185_07560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4185_07565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4185_07570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4185_07575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4185_07580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4185_07585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4185_07590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4185_07595	COG1841	ribosomal large subunit assembly
E4185_07600	COG0200	Binds to the 23S rRNA
E4185_07605	COG0201	protein transport
E4185_07610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4185_07615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4185_07620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4185_07625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4185_07630	COG0202	RNA polymerase activity
E4185_07635	COG0203	ribosomal protein L17
E4185_07690	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4185_07705	COG1770	oligopeptidase
E4185_07730	COG3714	YhhN family
E4185_07755	COG1301	dicarboxylic acid transport
E4185_07765	COG2095	MarC family integral membrane protein
E4185_07775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4185_07785	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4185_07790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4185_07820	COG0742	ribosomal rna small subunit methyltransferase
E4185_07825	COG0552	protein localization to endoplasmic reticulum
E4185_07830	COG2884	Cell division ATP-binding protein ftsE
E4185_07835	COG2177	Part of the ABC transporter FtsEX involved in
E4185_07845	COG0288	reversible hydration of carbon dioxide
E4185_07850	COG2188	Transcriptional regulator
E4185_07855	COG1228	amidohydrolase
E4185_07860	COG0010	Belongs to the arginase family
E4185_07865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4185_07870	COG2986	histidine ammonia-lyase
E4185_07875	COG0387	Pfam Sodium calcium exchanger
E4185_07880	COG2200	EAL domain
E4185_07885	COG2199	diguanylate cyclase activity
E4185_07885	COG2200	EAL domain
E4185_07930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4185_07935	COG1459	type II secretion system
E4185_07980	COG1077	Cell shape determining protein MreB Mrl
E4185_07985	COG1792	Involved in formation and maintenance of cell shape
E4185_07990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4185_07995	COG0424	maF-like protein
E4185_08000	COG1530	ribonuclease E activity
E4185_08005	COG3164	Protein of unknown function
E4185_08010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4185_08015	COG0312	modulator of DNA gyrase
E4185_08030	COG0477	Major facilitator Superfamily
E4185_08040	COG2321	neutral zinc metallopeptidase
E4185_08070	COG0189	ligase activity
E4185_08080	COG0745	RESPONSE REGULATOR receiver
E4185_08100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4185_08105	COG0352	thiamine-phosphate diphosphorylase activity
E4185_08110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4185_08120	COG2022	thiamine diphosphate biosynthetic process
E4185_08125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4185_08130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4185_08150	COG3706	GGDEF domain
E4185_08155	COG3932	Exopolysaccharide synthesis, ExoD
E4185_08195	COG1247	-acetyltransferase
E4185_08205	COG1494	fructose-1,6-bisphosphatase
E4185_08215	COG3071	HemY protein
E4185_08220	COG2959	enzyme of heme biosynthesis
E4185_08235	COG3072	Adenylate cyclase
E4185_08240	COG0400	carboxylic ester hydrolase activity
E4185_08245	COG1965	Belongs to the frataxin family
E4185_08255	COG0019	diaminopimelate decarboxylase activity
E4185_08260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4185_08275	COG1011	Hydrolase
E4185_08285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4185_08290	COG0561	phosphatase activity
E4185_08300	COG1988	membrane-bound metal-dependent
E4185_08305	COG1546	Belongs to the CinA family
E4185_08305	COG1058	Belongs to the CinA family
E4185_08315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4185_08325	COG1522	sequence-specific DNA binding
E4185_08335	COG3135	benzoate transporter
E4185_08340	COG1396	sequence-specific DNA binding
E4185_08370	COG2926	Belongs to the UPF0265 family
E4185_08380	COG3028	Belongs to the UPF0307 family
E4185_08390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4185_08395	COG5007	Belongs to the BolA IbaG family
E4185_08405	COG2854	intermembrane phospholipid transfer
E4185_08410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4185_08415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4185_08420	COG1127	ABC transporter
E4185_08425	COG0517	IMP dehydrogenase activity
E4185_08425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4185_08435	COG3117	lipopolysaccharide transmembrane transporter activity
E4185_08440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4185_08445	COG1137	ATPase activity
E4185_08460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_08465	COG1660	Displays ATPase and GTPase activities
E4185_08470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_08480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4185_08485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4185_08495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4185_08500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4185_08505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4185_08510	COG0723	plastoquinol--plastocyanin reductase activity
E4185_08520	COG2857	Cytochrome c1
E4185_08525	COG0625	glutathione transferase activity
E4185_08530	COG2969	positive regulation of protein catabolic process
E4185_08535	COG2823	Periplasmic or secreted lipoprotein
E4185_08545	COG0792	nuclease activity
E4185_08550	COG3107	peptidoglycan biosynthetic process
E4185_08555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4185_08565	COG2001	Belongs to the MraZ family
E4185_08570	COG0275	rRNA processing
E4185_08575	COG3116	cell division
E4185_08585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4185_08590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4185_08595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4185_08605	COG0772	Belongs to the SEDS family
E4185_08610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4185_08615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4185_08620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4185_08625	COG0849	cell division
E4185_08630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4185_08635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4185_08645	COG0653	protein targeting
E4185_08655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4185_08660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4185_08670	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4185_08675	COG1459	type II secretion system
E4185_08680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4185_08710	COG2186	Transcriptional regulator
E4185_08715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4185_08720	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4185_08725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4185_08730	COG3706	GGDEF domain
E4185_08745	COG0840	transmembrane signaling receptor activity
E4185_08755	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4185_08760	COG2200	EAL domain
E4185_08770	COG1280	lysine exporter protein (LysE YggA)
E4185_08780	COG0523	cobalamin synthesis protein
E4185_08800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4185_08805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4185_08935	COG5006	permease, DMT superfamily
E4185_08940	COG1522	sequence-specific DNA binding
E4185_08945	COG0110	maltose O-acetyltransferase activity
E4185_08950	COG0366	Alpha amylase catalytic
E4185_08955	COG1263	PTS System
E4185_08955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4185_08970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4185_08975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4185_08980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4185_08980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4185_08985	COG2723	6-phospho-beta-galactosidase activity
E4185_08990	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4185_08995	COG1940	carbohydrate kinase activity
E4185_09005	COG1609	Transcriptional regulator
E4185_09015	COG0252	asparaginase activity
E4185_09030	COG1803	Methylglyoxal synthase
E4185_09050	COG1444	tRNA N-acetyltransferase activity
E4185_09055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4185_09065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4185_09090	COG1612	heme a metabolic process
E4185_09095	COG0109	protoheme IX farnesyltransferase activity
E4185_09100	COG1012	belongs to the aldehyde dehydrogenase family
E4185_09105	COG1177	transmembrane transport
E4185_09110	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4185_09115	COG3842	ATPase activity
E4185_09120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4185_09125	COG0583	DNA-binding transcription factor activity
E4185_09130	COG1757	Na H antiporter
E4185_09170	COG0297	glycogen (starch) synthase activity
E4185_09175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4185_09180	COG2813	Specifically methylates the guanine in position
E4185_09185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4185_09190	COG4251	negative regulation of phosphorylation
E4185_09190	COG5001	Diguanylate cyclase
E4185_09190	COG3706	GGDEF domain
E4185_09190	COG2203	Gaf domain
E4185_09195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4185_09210	COG3008	intermembrane lipid transfer
E4185_09210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4185_09215	COG3009	Protein conserved in bacteria
E4185_09230	COG3240	lipase activity
E4185_09245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4185_09250	COG1194	a g-specific adenine glycosylase
E4185_09260	COG3267	Type II secretory pathway component ExeA
E4185_09260	COG3409	Peptidoglycan-binding domain 1 protein
E4185_09265	COG0617	tRNA 3'-terminal CCA addition
E4185_09270	COG0306	phosphate transporter
E4185_09275	COG1392	Phosphate transport regulator
E4185_09285	COG3133	Outer membrane lipoprotein
E4185_09305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4185_09310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4185_09320	COG3031	protein transport across the cell outer membrane
E4185_09330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4185_09335	COG1459	type II secretion system
E4185_09340	COG2165	general secretion pathway protein
E4185_09350	COG2165	general secretion pathway protein
E4185_09355	COG4795	General secretion pathway protein
E4185_09370	COG3156	type II secretion system protein K
E4185_09380	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4185_09395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4185_09400	COG1011	Hydrolase
E4185_09405	COG0494	nUDIX hydrolase
E4185_09410	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4185_09415	COG0814	amino acid
E4185_09420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4185_09435	COG0626	cystathionine gamma-synthase activity
E4185_09440	COG0460	homoserine dehydrogenase
E4185_09440	COG0527	aspartate kinase activity
E4185_09445	COG1346	cytolysis
E4185_09450	COG1380	Effector of murein hydrolase LrgA
E4185_09455	COG0583	DNA-binding transcription factor activity
E4185_09490	COG5002	protein histidine kinase activity
E4185_09490	COG5001	Diguanylate cyclase
E4185_09490	COG3447	MASE1 domain protein
E4185_09495	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4185_09505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4185_09510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4185_09520	COG0137	argininosuccinate synthase activity
E4185_09525	COG0165	Argininosuccinate lyase
E4185_09550	COG0110	maltose O-acetyltransferase activity
E4185_09555	COG3174	membrane
E4185_09560	COG1505	serine-type exopeptidase activity
E4185_09570	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_09590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4185_09600	COG2816	NAD+ diphosphatase activity
E4185_09605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4185_09610	COG1940	carbohydrate kinase activity
E4185_09615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4185_09620	COG0126	phosphoglycerate kinase activity
E4185_09625	COG0191	fructose-bisphosphate aldolase activity
E4185_09685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4185_09690	COG1595	DNA-templated transcription, initiation
E4185_09695	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4185_09710	COG0481	GTPase activity
E4185_09715	COG0681	Belongs to the peptidase S26 family
E4185_09720	COG0571	ribonuclease III activity
E4185_09730	COG1381	Involved in DNA repair and RecF pathway recombination
E4185_09735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4185_09740	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4185_09745	COG4807	Protein conserved in bacteria
E4185_09755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4185_09760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4185_09765	COG3956	TIGRFAM MazG family protein
E4185_09770	COG0504	CTP synthase activity
E4185_09775	COG0148	phosphopyruvate hydratase activity
E4185_09780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4185_09785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4185_09795	COG0585	pseudouridine synthase activity
E4185_09805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4185_09810	COG1238	metal cluster binding
E4185_09815	COG1388	LysM domain
E4185_09815	COG4942	peptidase
E4185_09825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4185_09830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4185_09835	COG1610	YqeY-like protein
E4185_09840	COG0358	DNA primase activity
E4185_09845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4185_09870	COG0151	Belongs to the GarS family
E4185_09875	COG0138	bifunctional purine biosynthesis protein purh
E4185_09890	COG3036	rescue of stalled ribosome
E4185_09895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4185_09900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4185_09910	COG0673	inositol 2-dehydrogenase activity
E4185_09920	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4185_09925	COG0330	HflC and HflK could
E4185_09930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4185_09930	COG1648	precorrin-2 dehydrogenase activity
E4185_09935	COG0175	sulfate reduction
E4185_09940	COG2895	sulfate adenylyltransferase (ATP) activity
E4185_09945	COG0471	metal ion transport
E4185_09945	COG3273	potassium ion transport
E4185_09950	COG0529	Catalyzes the synthesis of activated sulfate
E4185_09955	COG3039	Transposase
E4185_09990	COG1136	(ABC) transporter
E4185_10005	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4185_10020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4185_10025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4185_10030	COG0163	prenyltransferase activity
E4185_10045	COG1131	(ABC) transporter
E4185_10050	COG0842	Transport permease protein
E4185_10060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4185_10065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4185_10075	COG0617	tRNA 3'-terminal CCA addition
E4185_10080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4185_10085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4185_10090	COG1489	DNA binding
E4185_10095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4185_10100	COG1643	Atp-dependent helicase
E4185_10105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4185_10110	COG0346	lactoylglutathione lyase activity
E4185_10120	COG2076	Multidrug Resistance protein
E4185_10125	COG0583	DNA-binding transcription factor activity
E4185_10150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4185_10155	COG0038	chloride channel
E4185_10165	COG0316	Belongs to the HesB IscA family
E4185_10190	COG1280	lysine exporter protein (LysE YggA)
E4185_10215	COG4584	PFAM Integrase catalytic
E4185_10220	COG1484	DNA-dependent DNA replication
E4185_10265	COG4372	Transposase
E4185_10300	COG2003	Belongs to the UPF0758 family
E4185_10375	COG1136	(ABC) transporter
E4185_10385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4185_10395	COG2314	TM2 domain
E4185_10400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4185_10405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4185_10415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_10445	COG0745	RESPONSE REGULATOR receiver
E4185_10450	COG3104	oligopeptide transport
E4185_10455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4185_10460	COG1555	photosystem II stabilization
E4185_10470	COG2350	Protein conserved in bacteria
E4185_10475	COG2917	probably involved in intracellular septation
E4185_10480	COG0076	glutamate decarboxylase activity
E4185_10485	COG1272	protein, Hemolysin III
E4185_10490	COG0569	domain protein
E4185_10490	COG2985	domain, Protein
E4185_10500	COG0477	Major facilitator Superfamily
E4185_10505	COG0583	DNA-binding transcription factor activity
E4185_10510	COG3227	Zinc metalloprotease (Elastase)
E4185_10515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4185_10520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4185_10540	COG0668	transmembrane transport
E4185_10545	COG1376	ErfK ybiS ycfS ynhG family protein
E4185_10550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4185_10590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4185_10605	COG0517	IMP dehydrogenase activity
E4185_10610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4185_10615	COG0784	Response regulator, receiver
E4185_10615	COG0835	chemotaxis
E4185_10620	COG2755	lipolytic protein G-D-S-L family
E4185_10625	COG4181	ATPase activity
E4185_10635	COG1090	epimerase
E4185_10640	COG2200	EAL domain
E4185_10645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4185_10650	COG4935	Belongs to the peptidase S8 family
E4185_10650	COG2234	aminopeptidase activity
E4185_10655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4185_10660	COG3171	Protein conserved in bacteria
E4185_10665	COG2066	Belongs to the glutaminase family
E4185_10670	COG2897	thiosulfate sulfurtransferase activity
E4185_10710	COG0582	viral genome integration into host DNA
E4185_10730	COG3447	MASE1 domain protein
E4185_10730	COG5002	protein histidine kinase activity
E4185_10730	COG5001	Diguanylate cyclase
E4185_10735	COG4974	Belongs to the 'phage' integrase family
E4185_10770	COG3039	Transposase
E4185_10795	COG3039	Transposase
E4185_10800	COG2211	Major facilitator Superfamily
E4185_10810	COG1609	Transcriptional regulator
E4185_10820	COG2017	converts alpha-aldose to the beta-anomer
E4185_10825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4185_10835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4185_10850	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4185_10855	COG3300	MHYT domain
E4185_10855	COG5001	Diguanylate cyclase
E4185_10865	COG2207	Transcriptional regulator
E4185_10870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4185_10885	COG4628	conserved protein (DUF2132)
E4185_10890	COG0688	phosphatidylethanolamine metabolic process
E4185_10900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4185_10935	COG1278	Cold shock
E4185_10945	COG0840	transmembrane signaling receptor activity
E4185_10950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4185_10955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4185_11005	COG0848	biopolymer transport protein
E4185_11010	COG0811	peptide transport
E4185_11015	COG0811	peptide transport
E4185_11025	COG4206	TonB-dependent receptor
E4185_11030	COG4174	ABC transporter (Permease)
E4185_11035	COG4239	(ABC) transporter, permease
E4185_11040	COG0747	negative chemotaxis
E4185_11045	COG0444	Belongs to the ABC transporter superfamily
E4185_11050	COG4608	Belongs to the ABC transporter superfamily
E4185_11060	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4185_11075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4185_11095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4185_11120	COG0243	molybdopterin cofactor binding
E4185_11135	COG1116	anion transmembrane transporter activity
E4185_11135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4185_11140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4185_11145	COG1116	anion transmembrane transporter activity
E4185_11150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4185_11150	COG2146	nitrite reductase [NAD(P)H] activity
E4185_11155	COG2146	nitrite reductase [NAD(P)H] activity
E4185_11155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4185_11160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4185_11165	COG2313	pseudouridylate synthase activity
E4185_11210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4185_11215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4185_11240	COG2986	histidine ammonia-lyase
E4185_11265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4185_11275	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_11280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4185_11290	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4185_11305	COG2966	Psort location CytoplasmicMembrane, score
E4185_11310	COG3610	response to peptide
E4185_11320	COG4175	Glycine betaine
E4185_11325	COG4176	ABC-type proline glycine betaine transport system permease component
E4185_11330	COG2113	Glycine betaine
E4185_11335	COG0175	sulfate reduction
E4185_11340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4185_11345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4185_11350	COG0384	phenazine biosynthesis protein PhzF
E4185_11355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4185_11370	COG5001	Diguanylate cyclase
E4185_11385	COG0786	glutamate:sodium symporter activity
E4185_11390	COG0252	asparaginase activity
E4185_11395	COG3139	Protein of unknown function (DUF1315)
E4185_11415	COG0616	signal peptide processing
E4185_11420	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4185_11420	COG1902	pentaerythritol trinitrate reductase activity
E4185_11425	COG0778	Nitroreductase
E4185_11435	COG2264	protein methyltransferase activity
E4185_11440	COG0604	alcohol dehydrogenase
E4185_11445	COG0583	DNA-binding transcription factor activity
E4185_11450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4185_11450	COG2190	(PTS) system
E4185_11450	COG1263	PTS System
E4185_11455	COG4145	pantothenate transmembrane transporter activity
E4185_11460	COG3924	membrane
E4185_11465	COG0439	Biotin carboxylase
E4185_11470	COG0511	ligase activity, forming carbon-carbon bonds
E4185_11475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4185_11480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4185_11495	COG3381	protein complex oligomerization
E4185_11505	COG3005	denitrification pathway
E4185_11510	COG0745	RESPONSE REGULATOR receiver
E4185_11520	COG1879	ABC-type sugar transport system periplasmic component
E4185_11525	COG2205	protein histidine kinase activity
E4185_11525	COG2198	Histidine kinase
E4185_11525	COG0784	Response regulator, receiver
E4185_11535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4185_11550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4185_11570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4185_11575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4185_11580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4185_11585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4185_11590	COG4172	Belongs to the ABC transporter superfamily
E4185_11610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4185_11615	COG0142	geranyltranstransferase activity
E4185_11620	COG1722	exodeoxyribonuclease VII activity
E4185_11625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4185_11630	COG1360	Flagellar Motor Protein
E4185_11645	COG1534	Rna-binding protein
E4185_11650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4185_11660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4185_11665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4185_11670	COG0149	triose-phosphate isomerase activity
E4185_11675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4185_11690	COG0779	Required for maturation of 30S ribosomal subunits
E4185_11695	COG0195	Participates in both transcription termination and antitermination
E4185_11700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4185_11705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4185_11710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4185_11715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4185_11720	COG1185	polyribonucleotide nucleotidyltransferase activity
E4185_11725	COG2211	Major facilitator Superfamily
E4185_11730	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4185_11735	COG1422	Protein of unknown function (DUF1090)
E4185_11740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4185_11760	COG0312	modulator of DNA gyrase
E4185_11790	COG1970	mechanosensitive ion channel activity
E4185_11805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4185_11815	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4185_11825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4185_11835	COG0321	lipoyl(octanoyl) transferase activity
E4185_11840	COG2921	Belongs to the UPF0250 family
E4185_11845	COG1686	Belongs to the peptidase S11 family
E4185_11850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4185_11855	COG2951	lytic endotransglycosylase activity
E4185_11860	COG0772	Belongs to the SEDS family
E4185_11865	COG0768	penicillin binding
E4185_11870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4185_11875	COG0799	negative regulation of ribosome biogenesis
E4185_11880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4185_11895	COG0495	leucyl-tRNA aminoacylation
E4185_11900	COG2888	peptidyl-tyrosine sulfation
E4185_11905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4185_11910	COG4535	Mg2 and Co2 transporter CorC
E4185_11915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4185_11920	COG1702	phosphate starvation-inducible protein PhoH
E4185_11925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4185_11930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4185_11935	COG1278	Cold shock
E4185_11940	COG0583	DNA-binding transcription factor activity
E4185_11950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4185_11980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4185_11995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4185_12005	COG0516	GMP reductase activity
E4185_12015	COG0642	Histidine kinase
E4185_12020	COG0745	RESPONSE REGULATOR receiver
E4185_12030	COG0300	oxidoreductase activity
E4185_12040	COG1022	Amp-dependent synthetase and ligase
E4185_12050	COG4106	trans-aconitate 2-methyltransferase activity
E4185_12055	COG3214	Protein conserved in bacteria
E4185_12065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4185_12070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4185_12075	COG1053	succinate dehydrogenase
E4185_12085	COG0584	glycerophosphoryl diester phosphodiesterase
E4185_12090	COG1511	domain protein
E4185_12090	COG3264	Mechanosensitive ion channel
E4185_12100	COG0739	heme binding
E4185_12105	COG3121	Chaperone
E4185_12115	COG3121	Chaperone
E4185_12130	COG0583	DNA-binding transcription factor activity
E4185_12145	COG0583	DNA-binding transcription factor activity
E4185_12150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4185_12185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4185_12190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4185_12200	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4185_12205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4185_12215	COG0180	Tryptophanyl-tRNA synthetase
E4185_12230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4185_12240	COG1012	belongs to the aldehyde dehydrogenase family
E4185_12250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4185_12275	COG0490	domain, Protein
E4185_12275	COG0471	metal ion transport
E4185_12320	COG0012	GTP binding
E4185_12325	COG0193	aminoacyl-tRNA hydrolase activity
E4185_12330	COG0737	Belongs to the 5'-nucleotidase family
E4185_12335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4185_12345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4185_12350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4185_12355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4185_12360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4185_12365	COG2890	protein-(glutamine-N5) methyltransferase activity
E4185_12375	COG2912	Transglutaminase-like superfamily
E4185_12385	COG1301	dicarboxylic acid transport
E4185_12395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4185_12410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4185_12415	COG1115	amino acid carrier protein
E4185_12445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4185_12465	COG0189	ligase activity
E4185_12470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4185_12480	COG3091	SprT-like family
E4185_12490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4185_12510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4185_12515	COG0739	heme binding
E4185_12520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4185_12525	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4185_12525	COG3408	Glycogen debranching enzyme
E4185_12535	COG1881	PFAM PEBP family protein
E4185_12545	COG0583	DNA-binding transcription factor activity
E4185_12555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4185_12565	COG0583	DNA-binding transcription factor activity
E4185_12570	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_12575	COG0616	signal peptide processing
E4185_12580	COG3724	N-succinylarginine dihydrolase activity
E4185_12595	COG0840	transmembrane signaling receptor activity
E4185_12605	COG2971	BadF BadG BcrA BcrD
E4185_12615	COG4608	Belongs to the ABC transporter superfamily
E4185_12620	COG0444	Belongs to the ABC transporter superfamily
E4185_12625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4185_12640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4185_12660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4185_12715	COG1684	flagellar biosynthetic protein fliR
E4185_12725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4185_12750	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4185_12755	COG0643	Histidine kinase
E4185_12755	COG2198	Histidine kinase
E4185_12755	COG0784	Response regulator, receiver
E4185_12760	COG2201	protein-glutamate methylesterase activity
E4185_12765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4185_12770	COG1360	Flagellar Motor Protein
E4185_12775	COG1192	Involved in chromosome partitioning
E4185_12785	COG0835	chemotaxis
E4185_12805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4185_12810	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4185_12815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4185_12820	COG1138	Cytochrome C-type biogenesis protein
E4185_12825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4185_12830	COG4235	cytochrome complex assembly
E4185_12830	COG3088	subunit of a heme lyase
E4185_12855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4185_12860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4185_12860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4185_12875	COG0259	pyridoxamine-phosphate oxidase activity
E4185_12885	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4185_12890	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4185_12905	COG0083	homoserine kinase activity
E4185_12910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4185_12915	COG4319	ketosteroid isomerase
E4185_12935	COG5433	transposase activity
E4185_12965	COG1943	Transposase
E4185_12980	COG3220	belongs to the UPF0276 family
E4185_13010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4185_13015	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4185_13020	COG0746	molybdenum cofactor guanylyltransferase activity
E4185_13025	COG0281	malic enzyme
E4185_13045	COG2706	6-phosphogluconolactonase activity
E4185_13055	COG3264	Mechanosensitive ion channel
E4185_13055	COG1196	nuclear chromosome segregation
E4185_13060	COG0469	pyruvate kinase activity
E4185_13065	COG2850	peptidyl-arginine hydroxylation
E4185_13070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4185_13075	COG2915	High frequency lysogenization protein hflD homolog
E4185_13080	COG0482	sulfurtransferase activity
E4185_13100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4185_13110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4185_13110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_13110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4185_13140	COG5492	domain, Protein
E4185_13140	COG4932	domain protein
E4185_13160	COG1482	cell wall glycoprotein biosynthetic process
E4185_13165	COG2207	Transcriptional regulator
E4185_13170	COG0538	isocitrate dehydrogenase activity
E4185_13180	COG3048	D-serine ammonia-lyase activity
E4185_13185	COG2610	gluconate transmembrane transporter activity
E4185_13190	COG0583	DNA-binding transcription factor activity
E4185_13195	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4185_13200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4185_13215	COG0577	efflux transmembrane transporter activity
E4185_13215	COG1136	(ABC) transporter
E4185_13220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_13230	COG1227	inorganic diphosphatase activity
E4185_13235	COG0497	DNA recombination
E4185_13240	COG3706	GGDEF domain
E4185_13245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4185_13250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4185_13255	COG0443	Heat shock 70 kDa protein
E4185_13260	COG0484	heat shock protein binding
E4185_13290	COG1285	pathogenesis
E4185_13315	COG2391	methyltransferase activity
E4185_13330	COG1566	PFAM secretion protein HlyD family protein
E4185_13335	COG1136	(ABC) transporter
E4185_13335	COG0577	efflux transmembrane transporter activity
E4185_13340	COG0577	efflux transmembrane transporter activity
E4185_13340	COG1136	(ABC) transporter
E4185_13345	COG1136	(ABC) transporter
E4185_13345	COG0577	efflux transmembrane transporter activity
E4185_13355	COG0095	Lipoate-protein ligase
E4185_13360	COG5433	transposase activity
E4185_13385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_13390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_13400	COG0708	Exodeoxyribonuclease III
E4185_13415	COG0071	Belongs to the small heat shock protein (HSP20) family
E4185_13455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4185_13460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4185_13465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4185_13470	COG1845	cytochrome c oxidase, subunit III
E4185_13475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4185_13525	COG3550	peptidyl-serine autophosphorylation
E4185_13530	COG1396	sequence-specific DNA binding
E4185_13545	COG3039	Transposase
E4185_13555	COG0133	tryptophan synthase activity
E4185_13560	COG0135	phosphoribosylanthranilate isomerase activity
E4185_13560	COG0134	indole-3-glycerol-phosphate synthase activity
E4185_13570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4185_13570	COG0512	Glutamine amidotransferase of anthranilate synthase
E4185_13575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4185_13590	COG0009	L-threonylcarbamoyladenylate synthase
E4185_13600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4185_13615	COG1946	Acyl-CoA thioesterase
E4185_13630	COG1309	transcriptional regulator
E4185_13635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4185_13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_13655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4185_13665	COG1960	acyl-CoA dehydrogenase activity
E4185_13670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4185_13680	COG0469	pyruvate kinase activity
E4185_13685	COG1737	Transcriptional regulator
E4185_13695	COG2205	protein histidine kinase activity
E4185_13700	COG0745	RESPONSE REGULATOR receiver
E4185_13710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4185_13735	COG0463	Glycosyl transferase, family 2
E4185_13740	COG1215	transferase activity, transferring glycosyl groups
E4185_13745	COG0438	transferase activity, transferring glycosyl groups
E4185_13755	COG0297	glycogen (starch) synthase activity
E4185_13765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4185_13770	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4185_13780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4185_13795	COG3132	Protein of unknown function, DUF480
E4185_13835	COG1278	Cold shock
E4185_13865	COG0697	spore germination
E4185_13880	COG1187	pseudouridine synthase activity
E4185_13890	COG4166	transmembrane transport
E4185_13895	COG0622	Phosphoesterase
E4185_13910	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4185_13915	COG0784	Response regulator, receiver
E4185_13915	COG0835	chemotaxis
E4185_13920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4185_13925	COG1815	bacterial-type flagellum-dependent cell motility
E4185_13940	COG1749	Flagellar hook protein flgE
E4185_13955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4185_13960	COG1706	bacterial-type flagellum-dependent cell motility
E4185_13980	COG2239	Acts as a magnesium transporter
E4185_13990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4185_13995	COG2716	regulation of RNA biosynthetic process
E4185_14010	COG3852	Histidine kinase
E4185_14025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4185_14030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4185_14035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4185_14055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4185_14070	COG0590	tRNA wobble adenosine to inosine editing
E4185_14075	COG0573	inorganic phosphate transmembrane transporter activity
E4185_14080	COG0581	inorganic phosphate transmembrane transporter activity
E4185_14095	COG1253	flavin adenine dinucleotide binding
E4185_14110	COG0531	amino acid
E4185_14125	COG1126	abc transporter atp-binding protein
E4185_14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_14140	COG3706	GGDEF domain
E4185_14145	COG2271	Major facilitator Superfamily
E4185_14155	COG2197	response regulator
E4185_14160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4185_14185	COG1785	Belongs to the alkaline phosphatase family
E4185_14190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4185_14195	COG0477	Major facilitator Superfamily
E4185_14200	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4185_14210	COG1199	ATP-dependent helicase activity
E4185_14225	COG1448	Aminotransferase
E4185_14230	COG0433	COG0433 Predicted ATPase
E4185_14245	COG0658	competence protein
E4185_14245	COG2333	competence protein COMEC
E4185_14250	COG1132	(ABC) transporter
E4185_14255	COG1663	tetraacyldisaccharide 4'-kinase activity
E4185_14260	COG2835	tetraacyldisaccharide 4'-kinase activity
E4185_14265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4185_14270	COG2197	response regulator
E4185_14330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4185_14390	COG3039	Transposase
E4185_14400	COG2314	TM2 domain
E4185_14440	COG0625	glutathione transferase activity
E4185_14445	COG2261	transglycosylase associated protein
E4185_14450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4185_14460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4185_14500	COG2203	Gaf domain
E4185_14500	COG2199	diguanylate cyclase activity
E4185_14535	COG2119	membrane
E4185_14580	COG4139	cobalamin transport
E4185_14590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4185_14595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4185_14600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4185_14605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4185_14610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4185_14625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4185_14630	COG0505	Belongs to the CarA family
E4185_14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4185_14645	COG3706	GGDEF domain
E4185_14670	COG0513	Belongs to the DEAD box helicase family
E4185_14685	COG0789	Transcriptional regulator
E4185_14695	COG0493	'glutamate synthase
E4185_14700	COG0067	glutamate synthase
E4185_14700	COG0070	glutamate synthase
E4185_14700	COG0069	glutamate synthase activity
E4185_14705	COG1242	4 iron, 4 sulfur cluster binding
E4185_14770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4185_14775	COG0574	Belongs to the PEP-utilizing enzyme family
E4185_14775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4185_14790	COG1119	ATPase activity
E4185_14800	COG3039	Transposase
E4185_14810	COG1464	Belongs to the NlpA lipoprotein family
E4185_14815	COG0671	phosphoesterase, PA-phosphatase related
E4185_14820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4185_14825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4185_14835	COG0101	tRNA pseudouridine synthase activity
E4185_14840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4185_14845	COG0285	dihydrofolate synthase activity
E4185_14850	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4185_14855	COG2920	part of a sulfur-relay system
E4185_14860	COG1289	transmembrane transporter activity
E4185_14865	COG0670	Belongs to the BI1 family
E4185_14890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4185_14905	COG3246	L-lysine catabolic process to acetate
E4185_14910	COG2814	Major facilitator Superfamily
E4185_14920	COG2855	membrane
E4185_14945	COG4447	cellulose binding
E4185_14975	COG3706	GGDEF domain
E4185_14980	COG0564	pseudouridine synthase activity
E4185_14995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4185_15005	COG0625	glutathione transferase activity
E4185_15020	COG0367	asparagine synthase
E4185_15030	COG0647	UMP catabolic process
E4185_15035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4185_15040	COG1902	pentaerythritol trinitrate reductase activity
E4185_15045	COG1253	flavin adenine dinucleotide binding
E4185_15065	COG2050	protein possibly involved in aromatic compounds catabolism
E4185_15070	COG0513	Belongs to the DEAD box helicase family
E4185_15080	COG2814	Major facilitator Superfamily
E4185_15085	COG2056	Na+-H+ antiporter family
E4185_15090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4185_15105	COG0483	inositol monophosphate 1-phosphatase activity
E4185_15120	COG0625	glutathione transferase activity
E4185_15130	COG0601	transmembrane transport
E4185_15135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4185_15145	COG2814	Major facilitator Superfamily
E4185_15165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4185_15170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4185_15175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4185_15180	COG0509	glycine decarboxylation via glycine cleavage system
E4185_15185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4185_15185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4185_15190	COG5002	protein histidine kinase activity
E4185_15195	COG3328	transposase activity
E4185_15220	COG3634	alkyl hydroperoxide reductase activity
E4185_15230	COG0517	IMP dehydrogenase activity
E4185_15235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4185_15240	COG0343	queuine tRNA-ribosyltransferase activity
E4185_15245	COG1862	Preprotein translocase
E4185_15250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4185_15270	COG0826	peptidase U32
E4185_15275	COG0826	peptidase U32
E4185_15280	COG3154	lipid carrier protein
E4185_15300	COG1104	cysteine desulfurase activity
E4185_15305	COG0822	iron-sulfur transferase activity
E4185_15320	COG0443	Heat shock 70 kDa protein
E4185_15325	COG0633	Ferredoxin
E4185_15335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4185_15340	COG0105	UTP biosynthetic process
E4185_15345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4185_15365	COG0124	histidyl-tRNA synthetase
E4185_15370	COG2976	Protein conserved in bacteria
E4185_15375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4185_15380	COG1160	GTP binding
E4185_15390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4185_15400	COG1007	ATP synthesis coupled electron transport
E4185_15405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4185_15415	COG0713	ATP synthesis coupled electron transport
E4185_15420	COG0839	Belongs to the complex I subunit 6 family
E4185_15425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4185_15430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4185_15435	COG1034	ATP synthesis coupled electron transport
E4185_15450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4185_15450	COG0649	NAD binding
E4185_15455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4185_15460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4185_15465	COG1360	Flagellar Motor Protein
E4185_15470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4185_15485	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4185_15505	COG0724	RNA recognition motif
E4185_15510	COG4989	oxidoreductase activity
E4185_15535	COG3437	response regulator, receiver
E4185_15540	COG0583	DNA-binding transcription factor activity
E4185_15555	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4185_15560	COG0778	Nitroreductase
E4185_15585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4185_15590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4185_15595	COG0539	negative regulation of cytoplasmic translation
E4185_15600	COG0776	regulation of translation
E4185_15630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4185_15635	COG0602	queuosine metabolic process
E4185_15640	COG3530	Putative quorum-sensing-regulated virulence factor
E4185_15645	COG2096	Adenosyltransferase
E4185_15650	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4185_15655	COG1757	Na H antiporter
E4185_15660	COG1435	thymidine kinase activity
E4185_15680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4185_15695	COG3550	peptidyl-serine autophosphorylation
E4185_15795	COG2197	response regulator
E4185_15875	COG4584	PFAM Integrase catalytic
E4185_15880	COG1484	DNA-dependent DNA replication
E4185_15910	COG0629	single-stranded DNA binding
E4185_15915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4185_15960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4185_16005	COG3335	DDE superfamily endonuclease
E4185_16040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4185_16120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4185_16135	COG2910	NAD(P)H-binding
E4185_16170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4185_16175	COG3620	sequence-specific DNA binding
E4185_16175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4185_16175	COG0617	tRNA 3'-terminal CCA addition
E4185_16190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4185_16195	COG3046	protein related to deoxyribodipyrimidine photolyase
E4185_16210	COG3088	subunit of a heme lyase
E4185_16210	COG4235	cytochrome complex assembly
E4185_16215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4185_16225	COG3301	Polysulphide reductase, NrfD
E4185_16230	COG0437	4 iron, 4 sulfur cluster binding
E4185_16235	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4185_16250	COG0247	lactate metabolic process
E4185_16260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4185_16265	COG3012	SEC-C Motif Domain Protein
E4185_16275	COG1846	Transcriptional regulator
E4185_16275	COG1940	carbohydrate kinase activity
E4185_16280	COG3290	protein histidine kinase activity
E4185_16285	COG4565	transcriptional regulatory protein
E4185_16310	COG0569	domain protein
E4185_16310	COG2985	domain, Protein
E4185_16325	COG0556	nucleotide-excision repair
E4185_16335	COG0586	Pfam SNARE associated Golgi protein
E4185_16350	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4185_16360	COG2719	SpoVR family
E4185_16365	COG2718	Belongs to the UPF0229 family
E4185_16370	COG2766	serine protein kinase
E4185_16375	COG0514	ATP-dependent DNA helicase (RecQ)
E4185_16380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4185_16385	COG0814	amino acid
E4185_16415	COG0058	SHG alpha-glucan phosphorylase activity
E4185_16425	COG0471	metal ion transport
E4185_16430	COG3118	belongs to the thioredoxin family
E4185_16445	COG1132	(ABC) transporter
E4185_16460	COG2501	S4 domain
E4185_16490	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4185_16495	COG2329	Antibiotic biosynthesis monooxygenase
E4185_16500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4185_16510	COG0583	DNA-binding transcription factor activity
E4185_16520	COG1560	Kdo2-lipid A biosynthetic process
E4185_16550	COG0417	DNA replication proofreading
E4185_16590	COG0307	riboflavin synthase, alpha
E4185_16600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4185_16605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4185_16610	COG0697	spore germination
E4185_16615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4185_16650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4185_16655	COG3099	Belongs to the UPF0263 family
E4185_16660	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4185_16665	COG2894	cell division
E4185_16670	COG0850	regulation of cytokinetic process
E4185_16675	COG3100	YcgL domain-containing protein
E4185_16680	COG2951	lytic endotransglycosylase activity
E4185_16685	COG1760	l-serine dehydratase
E4185_16695	COG1760	l-serine dehydratase
E4185_16700	COG3123	guanosine phosphorylase activity
E4185_16740	COG5433	transposase activity
E4185_16770	COG3328	transposase activity
E4185_16785	COG4372	Transposase
E4185_16845	COG5433	transposase activity
E4185_16930	COG2067	long-chain fatty acid transport protein
E4185_16935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4185_16940	COG2067	long-chain fatty acid transport protein
E4185_16945	COG2067	long-chain fatty acid transport protein
E4185_16965	COG2304	oxidoreductase activity
E4185_16990	COG0714	Associated with various cellular activities
E4185_16995	COG0183	Belongs to the thiolase family
E4185_17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4185_17000	COG1024	Enoyl-CoA hydratase
E4185_17010	COG4681	YaeQ
E4185_17035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4185_17050	COG3134	Outer membrane lipoprotein
E4185_17055	COG0318	PFAM AMP-dependent synthetase and ligase
E4185_17060	COG2378	regulation of single-species biofilm formation
E4185_17070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4185_17070	COG0140	phosphoribosyl-ATP diphosphatase activity
E4185_17075	COG0107	imidazoleglycerol-phosphate synthase activity
E4185_17090	COG3437	response regulator, receiver
E4185_17095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4185_17100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4185_17105	COG0131	Imidazoleglycerol-phosphate dehydratase
E4185_17105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4185_17110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4185_17120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4185_17130	COG1199	ATP-dependent helicase activity
E4185_17170	COG0318	PFAM AMP-dependent synthetase and ligase
E4185_17175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4185_17185	COG0697	spore germination
E4185_17195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4185_17200	COG2832	Protein of unknown function (DUF454)
E4185_17205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4185_17215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4185_17220	COG1335	isochorismatase
E4185_17240	COG2197	response regulator
E4185_17245	COG0517	IMP dehydrogenase activity
E4185_17245	COG0617	tRNA 3'-terminal CCA addition
E4185_17245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4185_17250	COG1643	Atp-dependent helicase
E4185_17260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4185_17270	COG3437	response regulator, receiver
E4185_17275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4185_17280	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4185_17285	COG0709	Synthesizes selenophosphate from selenide and ATP
E4185_17295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4185_17305	COG0840	transmembrane signaling receptor activity
E4185_17310	COG1254	Belongs to the acylphosphatase family
E4185_17320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4185_17320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4185_17325	COG0489	protein tyrosine kinase activity
E4185_17330	COG0572	uridine kinase
E4185_17335	COG0717	Belongs to the dCTP deaminase family
E4185_17340	COG0306	phosphate transporter
E4185_17345	COG4584	PFAM Integrase catalytic
E4185_17430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4185_17435	COG2801	Transposase and inactivated derivatives
E4185_17465	COG4644	lycopene metabolic process
E4185_17470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4185_17480	COG3328	transposase activity
E4185_17485	COG1530	ribonuclease E activity
E4185_17495	COG0546	phosphoglycolate phosphatase activity
E4185_17500	COG0424	maF-like protein
E4185_17510	COG1399	metal-binding, possibly nucleic acid-binding protein
E4185_17515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4185_17520	COG0416	fatty acid biosynthetic process
E4185_17525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4185_17535	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_17540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4185_17550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4185_17555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4185_17560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4185_17565	COG0470	DNA polymerase III
E4185_17570	COG0084	hydrolase, TatD family'
E4185_17590	COG2801	Transposase and inactivated derivatives
E4185_17605	COG3008	intermembrane lipid transfer
E4185_17610	COG2995	paraquat-inducible protein a
E4185_17620	COG3141	response to X-ray
E4185_17625	COG4974	Belongs to the 'phage' integrase family
E4185_17705	COG1067	ATP-dependent peptidase activity
E4185_17710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4185_17725	COG0488	(ABC) transporter
E4185_17735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4185_17735	COG0116	Belongs to the methyltransferase superfamily
E4185_17745	COG0167	dihydroorotate dehydrogenase activity
E4185_17750	COG2902	Dehydrogenase
E4185_17760	COG0308	aminopeptidase N
E4185_17770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4185_17775	COG1956	GAF domain-containing protein
E4185_17785	COG3278	Belongs to the heme-copper respiratory oxidase family
E4185_17800	COG2010	Cytochrome c
E4185_17825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4185_17830	COG0589	response to stress
E4185_17835	COG0037	tRNA processing
E4185_17855	COG1869	D-ribose catabolic process
E4185_17860	COG1129	ABC transporter
E4185_17865	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4185_17870	COG1879	ABC-type sugar transport system periplasmic component
E4185_17875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4185_17880	COG1609	Transcriptional regulator
E4185_17885	COG5001	Diguanylate cyclase
E4185_17885	COG3300	MHYT domain
E4185_17915	COG0776	regulation of translation
E4185_17920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4185_17920	COG0072	phenylalanine-tRNA ligase activity
E4185_17925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4185_17930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4185_17935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4185_17940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4185_17945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4185_17970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4185_17980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4185_17985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4185_17990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4185_17995	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4185_18000	COG3313	Fe-S protein
E4185_18005	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4185_18005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4185_18005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4185_18010	COG1105	Belongs to the carbohydrate kinase PfkB family
E4185_18015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_18015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_18020	COG1609	Transcriptional regulator
E4185_18025	COG0814	amino acid
E4185_18030	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4185_18035	COG0513	Belongs to the DEAD box helicase family
E4185_18045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4185_18065	COG0406	alpha-ribazole phosphatase activity
E4185_18095	COG2824	Alkylphosphonate utilization operon protein PhnA
E4185_18155	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4185_18165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4185_18170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4185_18180	COG0205	6-phosphofructokinase activity
E4185_18185	COG1473	amidohydrolase
E4185_18190	COG1011	Hydrolase
E4185_18195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4185_18245	COG3593	DNA synthesis involved in DNA repair
E4185_18260	COG0583	DNA-binding transcription factor activity
E4185_18285	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4185_18295	COG0386	Belongs to the glutathione peroxidase family
E4185_18300	COG0513	Belongs to the DEAD box helicase family
E4185_18315	COG1742	UPF0060 membrane protein
E4185_18340	COG3706	GGDEF domain
E4185_18350	COG3706	GGDEF domain
E4185_18355	COG5433	transposase activity
E4185_18375	COG0583	DNA-binding transcription factor activity
E4185_18380	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_18390	COG0583	DNA-binding transcription factor activity
E4185_18395	COG3706	GGDEF domain
E4185_18405	COG0243	molybdopterin cofactor binding
E4185_18410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4185_18425	COG0583	DNA-binding transcription factor activity
E4185_18430	COG5433	transposase activity
E4185_18435	COG1879	ABC-type sugar transport system periplasmic component
E4185_18440	COG1129	ABC transporter
E4185_18445	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4185_18500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4185_18510	COG0789	Transcriptional regulator
E4185_18580	COG2003	Belongs to the UPF0758 family
E4185_18610	COG3586	endonuclease activity
E4185_18625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4185_18645	COG0730	response to heat
E4185_18655	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_18665	COG1024	Enoyl-CoA hydratase
E4185_18670	COG1024	Enoyl-CoA hydratase
E4185_18675	COG1960	acyl-CoA dehydrogenase activity
E4185_18685	COG1960	acyl-CoA dehydrogenase activity
E4185_18690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4185_18695	COG1024	Enoyl-CoA hydratase
E4185_18720	COG1584	GPR1 FUN34 yaaH family protein
E4185_18735	COG1115	amino acid carrier protein
E4185_18740	COG1024	Enoyl-CoA hydratase
E4185_18750	COG2176	DNA-directed DNA polymerase activity
E4185_18755	COG3162	membrane
E4185_18760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4185_18765	COG0488	(ABC) transporter
E4185_18770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4185_18775	COG0776	regulation of translation
E4185_18780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4185_18785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4185_18790	COG0740	serine-type endopeptidase activity
E4185_18795	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4185_18815	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4185_18820	COG1136	(ABC) transporter
E4185_18835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4185_18840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4185_18845	COG4166	transmembrane transport
E4185_18855	COG0697	spore germination
E4185_18865	COG2062	phosphohistidine phosphatase, SixA
E4185_18910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4185_18910	COG0519	Catalyzes the synthesis of GMP from XMP
E4185_18915	COG0517	IMP dehydrogenase activity
E4185_18915	COG0516	GMP reductase activity
E4185_18925	COG0366	Alpha amylase catalytic
E4185_18925	COG1874	Beta-galactosidase
E4185_18935	COG1570	exodeoxyribonuclease VII activity
E4185_18945	COG2885	chlorophyll binding
E4185_18950	COG2199	diguanylate cyclase activity
E4185_18965	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4185_18975	COG3768	UPF0283 membrane protein
E4185_18980	COG3106	COG3106 Predicted ATPase
E4185_18995	COG1842	Phage shock protein A
E4185_19000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4185_19010	COG4168	peptide transport system, permease
E4185_19015	COG4171	peptide transport system, permease
E4185_19030	COG4172	Belongs to the ABC transporter superfamily
E4185_19040	COG1609	Transcriptional regulator
E4185_19045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4185_19045	COG1263	PTS System
E4185_19050	COG2723	6-phospho-beta-galactosidase activity
E4185_19055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4185_19060	COG1286	toxin biosynthetic process
E4185_19065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4185_19070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4185_19075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4185_19080	COG1674	ftsk spoiiie
E4185_19080	COG0531	amino acid
E4185_19090	COG0686	Belongs to the AlaDH PNT family
E4185_19095	COG0492	ferredoxin-NADP+ reductase activity
E4185_19100	COG3706	GGDEF domain
E4185_19105	COG3134	Outer membrane lipoprotein
E4185_19110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4185_19115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4185_19120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4185_19125	COG0542	response to heat
E4185_19130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4185_19135	COG1278	Cold shock
E4185_19140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4185_19155	COG1944	ATP diphosphatase activity
E4185_19160	COG2116	formate transmembrane transporter activity
E4185_19165	COG1882	Formate acetyltransferase
E4185_19170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4185_19180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4185_19190	COG1840	ABC-type Fe3 transport system, periplasmic component
E4185_19195	COG3842	ATPase activity
E4185_19205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4185_19210	COG2983	Belongs to the UPF0260 family
E4185_19230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4185_19235	COG0045	succinate-CoA ligase (ADP-forming) activity
E4185_19240	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4185_19245	COG0567	Dehydrogenase, E1 component
E4185_19255	COG1053	succinate dehydrogenase
E4185_19260	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4185_19285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4185_19300	COG3069	C4-dicarboxylate transmembrane transporter activity
E4185_19315	COG1451	nucleotide metabolic process
E4185_19330	COG0254	rRNA binding
E4185_19335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4185_19345	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4185_19355	COG1879	ABC-type sugar transport system periplasmic component
E4185_19360	COG1069	ribulokinase activity
E4185_19370	COG2160	L-arabinose isomerase activity
E4185_19375	COG0583	DNA-binding transcription factor activity
E4185_19380	COG0436	Aminotransferase
E4185_19385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4185_19400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4185_19400	COG0392	lysyltransferase activity
E4185_19405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4185_19410	COG2925	Exonuclease
E4185_19420	COG3345	alpha-galactosidase
E4185_19425	COG1380	Effector of murein hydrolase LrgA
E4185_19430	COG1346	cytolysis
E4185_19435	COG0295	cytidine deaminase activity
E4185_19440	COG1022	Amp-dependent synthetase and ligase
E4185_19455	COG0861	Integral membrane protein TerC family
E4185_19460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4185_19465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4185_19470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4185_19510	COG4771	TonB-dependent receptor
E4185_19515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4185_19520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4185_19525	COG1120	ATPase activity
E4185_19535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4185_19540	COG0300	oxidoreductase activity
E4185_19540	COG3321	synthase
E4185_19540	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_19540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4185_19540	COG0318	PFAM AMP-dependent synthetase and ligase
E4185_19550	COG1028	Short-chain dehydrogenase reductase Sdr
E4185_19560	COG3433	isochorismatase activity
E4185_19560	COG1535	isochorismatase
E4185_19565	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4185_19610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4185_19620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4185_19625	COG0563	adenylate kinase activity
E4185_19630	COG0326	Molecular chaperone. Has ATPase activity
E4185_19635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4185_19640	COG3039	Transposase
E4185_19670	COG2308	Evidence 4 Homologs of previously reported genes of
E4185_19705	COG0672	)-iron permease
E4185_19730	COG2814	Major facilitator Superfamily
E4185_19750	COG1136	(ABC) transporter
E4185_19765	COG3039	Transposase
E4185_19780	COG1139	Iron-sulfur cluster binding protein
E4185_19785	COG0247	lactate metabolic process
E4185_19795	COG0583	DNA-binding transcription factor activity
E4185_19805	COG2315	Protein conserved in bacteria
E4185_19820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4185_19825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4185_19825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4185_19835	COG0527	aspartate kinase activity
E4185_19845	COG1368	sulfuric ester hydrolase activity
E4185_19850	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4185_19855	COG0393	Putative heavy-metal-binding
E4185_19865	COG1252	NADH dehydrogenase
E4185_19870	COG3150	esterase
E4185_19885	COG2354	Protein conserved in bacteria
E4185_19895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4185_19900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4185_19940	COG0537	adenosine 5'-monophosphoramidase activity
E4185_19955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4185_19975	COG0675	Transposase, IS605 OrfB family
E4185_19995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4185_20000	COG0861	Integral membrane protein TerC family
E4185_20010	COG0444	Belongs to the ABC transporter superfamily
E4185_20015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4185_20020	COG0601	transmembrane transport
E4185_20030	COG2095	MarC family integral membrane protein
E4185_20035	COG1012	belongs to the aldehyde dehydrogenase family
E4185_20035	COG1454	alcohol dehydrogenase
E4185_20045	COG3275	phosphorelay sensor kinase activity
E4185_20050	COG3279	Response regulator of the LytR AlgR family
E4185_20055	COG1966	Carbon starvation protein
E4185_20060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4185_20060	COG3264	Mechanosensitive ion channel
E4185_20070	COG1566	PFAM secretion protein HlyD family protein
E4185_20075	COG1061	Type III restriction enzyme res subunit
E4185_20080	COG2027	D-alanyl-D-alanine carboxypeptidase
E4185_20085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4185_20095	COG0436	Aminotransferase
E4185_20100	COG1288	antiporter activity
E4185_20105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4185_20125	COG0697	spore germination
E4185_20130	COG4657	Part of a membrane complex involved in electron transport
E4185_20135	COG2878	Part of a membrane complex involved in electron transport
E4185_20140	COG4656	Part of a membrane complex involved in electron transport
E4185_20145	COG4658	electron transport chain
E4185_20150	COG4659	FMN binding
E4185_20155	COG4660	Part of a membrane complex involved in electron transport
E4185_20160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4185_20165	COG0346	lactoylglutathione lyase activity
E4185_20180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4185_20190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4185_20200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4185_20210	COG2089	acid synthase
E4185_20215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4185_20225	COG2226	methyltransferase
E4185_20230	COG1083	cytidylyl-transferase
E4185_20265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4185_20270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4185_20285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4185_20285	COG0301	tRNA thio-modification
E4185_20295	COG4953	penicillin-binding protein 1C
E4185_20300	COG2373	Large extracellular alpha-helical protein
E4185_20310	COG5433	transposase activity
E4185_20315	COG5433	transposase activity
E4185_20345	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4185_20355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4185_20375	COG5433	transposase activity
E4185_20430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_20440	COG2431	L-lysine efflux transmembrane transporter activity
E4185_20465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4185_20480	COG1228	amidohydrolase
E4185_20490	COG1393	Belongs to the ArsC family
E4185_20500	COG4783	chaperone-mediated protein folding
E4185_20530	COG3842	ATPase activity
E4185_20535	COG3833	ABC-type maltose transport systems, permease component
E4185_20540	COG1175	transmembrane transport
E4185_20545	COG2182	Extracellular solute-binding protein
E4185_20550	COG3081	Nucleoid-associated protein
E4185_20555	COG3082	Protein of unknown function (DUF1414)
E4185_20560	COG3083	sulfuric ester hydrolase activity
E4185_20565	COG4771	TonB-dependent receptor
E4185_20570	COG1770	oligopeptidase
E4185_20590	COG4574	serine-type endopeptidase inhibitor activity
E4185_20595	COG3085	chromosome segregation
E4185_20605	COG0287	Prephenate dehydrogenase
E4185_20605	COG1605	Chorismate mutase
E4185_20610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4185_20615	COG0584	glycerophosphoryl diester phosphodiesterase
E4185_20625	COG1349	DNA-binding transcription factor activity
E4185_20630	COG2271	Major facilitator Superfamily
E4185_20635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4185_20640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4185_20645	COG0583	DNA-binding transcription factor activity
E4185_20665	COG0656	L-ascorbic acid biosynthetic process
E4185_20670	COG2814	Major facilitator Superfamily
E4185_20680	COG1294	oxidase, subunit
E4185_20690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4185_20705	COG1595	DNA-templated transcription, initiation
E4185_20720	COG2979	Protein of unknown function (DUF533)
E4185_20760	COG2807	transmembrane transport
E4185_20765	COG1187	pseudouridine synthase activity
E4185_20770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4185_20825	COG1166	arginine decarboxylase activity
E4185_20845	COG0675	Transposase, IS605 OrfB family
E4185_20865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4185_20880	COG0583	DNA-binding transcription factor activity
E4185_20890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4185_20895	COG0840	transmembrane signaling receptor activity
E4185_20900	COG0302	gtp cyclohydrolase
E4185_20910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4185_20915	COG0596	Alpha beta hydrolase
E4185_20920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4185_20935	COG0314	molybdopterin synthase activity
E4185_20940	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4185_20945	COG0315	cyclic pyranopterin monophosphate synthase activity
E4185_20950	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4185_20955	COG3005	denitrification pathway
E4185_20965	COG0348	domain, Protein
E4185_20970	COG0437	4 iron, 4 sulfur cluster binding
E4185_20975	COG0243	molybdopterin cofactor binding
E4185_20980	COG3062	negative regulation of establishment of protein localization
E4185_20985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4185_20990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4185_20995	COG3850	Histidine kinase
E4185_21000	COG2197	response regulator
E4185_21025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4185_21035	COG0121	glutamine amidotransferase
E4185_21040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4185_21045	COG1960	acyl-CoA dehydrogenase activity
E4185_21055	COG5433	transposase activity
E4185_21075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4185_21080	COG0328	RNA-DNA hybrid ribonuclease activity
E4185_21085	COG2226	methyltransferase
E4185_21090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4185_21095	COG1388	LysM domain
E4185_21095	COG0741	lytic transglycosylase activity
E4185_21110	COG1607	acyl-coa hydrolase
E4185_21125	COG0741	lytic transglycosylase activity
E4185_21135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4185_21155	COG2911	Protein conserved in bacteria
E4185_21170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4185_21180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4185_21190	COG4134	Bacterial extracellular solute-binding protein
E4185_21205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4185_21210	COG2951	lytic endotransglycosylase activity
E4185_21215	COG1846	Transcriptional regulator
E4185_21225	COG0033	Phosphoglucomutase
E4185_21230	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4185_21235	COG0596	Alpha beta hydrolase
E4185_21250	COG0716	FMN binding
E4185_21260	COG0735	belongs to the Fur family
E4185_21265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4185_21275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4185_21275	COG1263	PTS System
E4185_21275	COG2190	(PTS) system
E4185_21280	COG0363	glucosamine-6-phosphate deaminase activity
E4185_21285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4185_21290	COG1846	Transcriptional regulator
E4185_21290	COG1940	carbohydrate kinase activity
E4185_21300	COG0217	transcriptional regulatory protein
E4185_21305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4185_21315	COG1801	Protein of unknown function DUF72
E4185_21320	COG4106	trans-aconitate 2-methyltransferase activity
E4185_21325	COG0500	methyltransferase
E4185_21345	COG0583	DNA-binding transcription factor activity
E4185_21350	COG0791	NLP P60 protein
E4185_21365	COG1309	transcriptional regulator
E4185_21400	COG0534	Mate efflux family protein
E4185_21410	COG2841	Protein conserved in bacteria
E4185_21420	COG2366	antibiotic biosynthetic process
E4185_21425	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4185_21425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4185_21425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4185_21425	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4185_21435	COG0633	Ferredoxin
E4185_21435	COG3217	Mosc domain protein beta barrel domain protein
E4185_21435	COG0633	Ferredoxin
E4185_21435	COG3217	Mosc domain protein beta barrel domain protein
E4185_21440	COG0501	Belongs to the peptidase M48B family
E4185_21450	COG2226	methyltransferase
E4185_21450	COG1073	alpha beta
E4185_21455	COG0156	8-amino-7-oxononanoate synthase activity
E4185_21460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4185_21480	COG0017	Asparaginyl-tRNA synthetase
E4185_21485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4185_21505	COG1393	Belongs to the ArsC family
E4185_21510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4185_21515	COG1876	peptidase activity
E4185_21525	COG3263	regulation of cellular component size
E4185_21540	COG1280	lysine exporter protein (LysE YggA)
E4185_21570	COG0564	pseudouridine synthase activity
E4185_21580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4185_21585	COG0702	epimerase
E4185_21595	COG2867	negative regulation of translational initiation
E4185_21600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4185_21815	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4185_21830	COG3645	SOS response
E4185_21830	COG3646	Phage regulatory protein
E4185_21865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4185_21970	COG3328	transposase activity
E4185_21975	COG0582	viral genome integration into host DNA
E4185_22010	COG3153	acetyltransferase
E4185_22045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4185_22055	COG0745	RESPONSE REGULATOR receiver
E4185_22070	COG4988	ABC transporter
E4185_22075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4185_22095	COG1720	tRNA m6t6A37 methyltransferase activity
E4185_22110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4185_22115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4185_22120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4185_22130	COG2190	(PTS) system
E4185_22135	COG3038	cytochrome b561
E4185_22145	COG0420	3'-5' exonuclease activity
E4185_22150	COG0456	acetyltransferase
E4185_22155	COG2974	May be involved in recombination
E4185_22175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4185_22180	COG1396	sequence-specific DNA binding
E4185_22180	COG1917	Cupin 2, conserved barrel domain protein
E4185_22195	COG0531	amino acid
E4185_22200	COG0531	amino acid
E4185_22210	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4185_22220	COG3384	dioxygenase
E4185_22225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4185_22225	COG2205	protein histidine kinase activity
E4185_22250	COG0784	Response regulator, receiver
E4185_22250	COG2205	protein histidine kinase activity
E4185_22300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes