locus-tag	class	description
E4188_00015	COG0297	glycogen (starch) synthase activity
E4188_00020	COG0438	transferase activity, transferring glycosyl groups
E4188_00070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4188_00125	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4188_00140	COG0745	RESPONSE REGULATOR receiver
E4188_00155	COG1737	Transcriptional regulator
E4188_00160	COG0469	pyruvate kinase activity
E4188_00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_00175	COG1960	acyl-CoA dehydrogenase activity
E4188_00185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4188_00215	COG5433	transposase activity
E4188_00225	COG3039	Transposase
E4188_00250	COG3657	addiction module killer protein
E4188_00270	COG1484	DNA-dependent DNA replication
E4188_00275	COG4584	PFAM Integrase catalytic
E4188_00290	COG3039	Transposase
E4188_00310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_00320	COG1309	transcriptional regulator
E4188_00335	COG1946	Acyl-CoA thioesterase
E4188_00345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4188_00355	COG0009	L-threonylcarbamoyladenylate synthase
E4188_00370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4188_00375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4188_00375	COG0512	Glutamine amidotransferase of anthranilate synthase
E4188_00380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4188_00385	COG0134	indole-3-glycerol-phosphate synthase activity
E4188_00385	COG0135	phosphoribosylanthranilate isomerase activity
E4188_00390	COG0133	tryptophan synthase activity
E4188_00395	COG0159	tryptophan synthase activity
E4188_00405	COG5433	transposase activity
E4188_00410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4188_00420	COG3550	peptidyl-serine autophosphorylation
E4188_00455	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4188_00460	COG2814	Major facilitator Superfamily
E4188_00470	COG0109	protoheme IX farnesyltransferase activity
E4188_00475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4188_00480	COG1845	cytochrome c oxidase, subunit III
E4188_00485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4188_00490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4188_00495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_00500	COG0583	DNA-binding transcription factor activity
E4188_00540	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_00565	COG0708	Exodeoxyribonuclease III
E4188_00575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_00580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_00595	COG0095	Lipoate-protein ligase
E4188_00615	COG2391	methyltransferase activity
E4188_00640	COG1285	pathogenesis
E4188_00670	COG0484	heat shock protein binding
E4188_00675	COG0443	Heat shock 70 kDa protein
E4188_00680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4188_00685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4188_00695	COG0497	DNA recombination
E4188_00700	COG1227	inorganic diphosphatase activity
E4188_00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_00715	COG0577	efflux transmembrane transporter activity
E4188_00715	COG1136	(ABC) transporter
E4188_00725	COG2375	cellular response to nickel ion
E4188_00730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_00735	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_00740	COG0583	DNA-binding transcription factor activity
E4188_00745	COG2610	gluconate transmembrane transporter activity
E4188_00750	COG3048	D-serine ammonia-lyase activity
E4188_00760	COG0538	isocitrate dehydrogenase activity
E4188_00765	COG2207	Transcriptional regulator
E4188_00770	COG1482	cell wall glycoprotein biosynthetic process
E4188_00790	COG5492	domain, Protein
E4188_00790	COG4932	domain protein
E4188_00810	COG0583	DNA-binding transcription factor activity
E4188_00815	COG4584	PFAM Integrase catalytic
E4188_00820	COG1484	DNA-dependent DNA replication
E4188_00855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_00855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_00855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_00865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_00885	COG0482	sulfurtransferase activity
E4188_00890	COG2915	High frequency lysogenization protein hflD homolog
E4188_00895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4188_00900	COG2850	peptidyl-arginine hydroxylation
E4188_00905	COG0469	pyruvate kinase activity
E4188_00910	COG1196	nuclear chromosome segregation
E4188_00910	COG3264	Mechanosensitive ion channel
E4188_00920	COG2706	6-phosphogluconolactonase activity
E4188_00940	COG0281	malic enzyme
E4188_00945	COG0746	molybdenum cofactor guanylyltransferase activity
E4188_00950	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4188_00955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4188_01015	COG4319	ketosteroid isomerase
E4188_01020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4188_01025	COG0083	homoserine kinase activity
E4188_01040	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4188_01045	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4188_01055	COG0259	pyridoxamine-phosphate oxidase activity
E4188_01080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_01080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_01085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4188_01105	COG4235	cytochrome complex assembly
E4188_01105	COG3088	subunit of a heme lyase
E4188_01110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_01115	COG1138	Cytochrome C-type biogenesis protein
E4188_01120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4188_01125	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_01130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_01135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_01150	COG0835	chemotaxis
E4188_01155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_01180	COG1192	Involved in chromosome partitioning
E4188_01185	COG1360	Flagellar Motor Protein
E4188_01190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_01195	COG2201	protein-glutamate methylesterase activity
E4188_01200	COG2198	Histidine kinase
E4188_01200	COG0784	Response regulator, receiver
E4188_01200	COG0643	Histidine kinase
E4188_01205	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4188_01230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4188_01245	COG1684	flagellar biosynthetic protein fliR
E4188_01305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4188_01325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4188_01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_01345	COG0444	Belongs to the ABC transporter superfamily
E4188_01350	COG4608	Belongs to the ABC transporter superfamily
E4188_01360	COG2971	BadF BadG BcrA BcrD
E4188_01370	COG0840	transmembrane signaling receptor activity
E4188_01385	COG3724	N-succinylarginine dihydrolase activity
E4188_01390	COG0616	signal peptide processing
E4188_01395	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_01400	COG0583	DNA-binding transcription factor activity
E4188_01410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4188_01420	COG0583	DNA-binding transcription factor activity
E4188_01430	COG1881	PFAM PEBP family protein
E4188_01440	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4188_01440	COG3408	Glycogen debranching enzyme
E4188_01445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4188_01450	COG0739	heme binding
E4188_01455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4188_01465	COG5433	transposase activity
E4188_01500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4188_01510	COG3091	SprT-like family
E4188_01520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4188_01525	COG0189	ligase activity
E4188_01545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4188_01575	COG1115	amino acid carrier protein
E4188_01580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4188_01595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4188_01630	COG2912	Transglutaminase-like superfamily
E4188_01640	COG2890	protein-(glutamine-N5) methyltransferase activity
E4188_01645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4188_01650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4188_01655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4188_01660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4188_01670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4188_01675	COG0737	Belongs to the 5'-nucleotidase family
E4188_01680	COG0193	aminoacyl-tRNA hydrolase activity
E4188_01685	COG0012	GTP binding
E4188_01730	COG0490	domain, Protein
E4188_01730	COG0471	metal ion transport
E4188_01755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_01765	COG1012	belongs to the aldehyde dehydrogenase family
E4188_01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4188_01790	COG0180	Tryptophanyl-tRNA synthetase
E4188_01800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4188_01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4188_01815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4188_01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4188_01855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4188_01860	COG0583	DNA-binding transcription factor activity
E4188_01875	COG0583	DNA-binding transcription factor activity
E4188_01890	COG3121	Chaperone
E4188_01900	COG3121	Chaperone
E4188_01905	COG0739	heme binding
E4188_01915	COG1511	domain protein
E4188_01915	COG3264	Mechanosensitive ion channel
E4188_01920	COG0584	glycerophosphoryl diester phosphodiesterase
E4188_01930	COG1053	succinate dehydrogenase
E4188_01935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4188_01940	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4188_01950	COG3214	Protein conserved in bacteria
E4188_01955	COG4106	trans-aconitate 2-methyltransferase activity
E4188_01965	COG1022	Amp-dependent synthetase and ligase
E4188_01975	COG0300	oxidoreductase activity
E4188_01985	COG0745	RESPONSE REGULATOR receiver
E4188_01990	COG0642	Histidine kinase
E4188_02000	COG0516	GMP reductase activity
E4188_02010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4188_02015	COG3647	Membrane
E4188_02025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4188_02035	COG2199	diguanylate cyclase activity
E4188_02055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_02065	COG0583	DNA-binding transcription factor activity
E4188_02070	COG1278	Cold shock
E4188_02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_02080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4188_02085	COG1702	phosphate starvation-inducible protein PhoH
E4188_02090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4188_02095	COG4535	Mg2 and Co2 transporter CorC
E4188_02100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4188_02105	COG2888	peptidyl-tyrosine sulfation
E4188_02110	COG0495	leucyl-tRNA aminoacylation
E4188_02125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4188_02130	COG0799	negative regulation of ribosome biogenesis
E4188_02135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4188_02140	COG0768	penicillin binding
E4188_02145	COG0772	Belongs to the SEDS family
E4188_02150	COG2951	lytic endotransglycosylase activity
E4188_02155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4188_02160	COG1686	Belongs to the peptidase S11 family
E4188_02165	COG2921	Belongs to the UPF0250 family
E4188_02170	COG0321	lipoyl(octanoyl) transferase activity
E4188_02180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4188_02190	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_02200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4188_02215	COG1970	mechanosensitive ion channel activity
E4188_02225	COG4974	Belongs to the 'phage' integrase family
E4188_02245	COG0312	modulator of DNA gyrase
E4188_02265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4188_02285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4188_02290	COG2211	Major facilitator Superfamily
E4188_02295	COG1185	polyribonucleotide nucleotidyltransferase activity
E4188_02300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4188_02305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4188_02310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4188_02315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4188_02320	COG0195	Participates in both transcription termination and antitermination
E4188_02325	COG0779	Required for maturation of 30S ribosomal subunits
E4188_02340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4188_02345	COG0149	triose-phosphate isomerase activity
E4188_02350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4188_02355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4188_02365	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4188_02370	COG1534	Rna-binding protein
E4188_02385	COG1360	Flagellar Motor Protein
E4188_02390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_02395	COG1722	exodeoxyribonuclease VII activity
E4188_02400	COG0142	geranyltranstransferase activity
E4188_02405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4188_02425	COG4172	Belongs to the ABC transporter superfamily
E4188_02430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4188_02435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4188_02440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_02445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4188_02460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4188_02460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4188_02465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4188_02480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4188_02490	COG2198	Histidine kinase
E4188_02490	COG2205	protein histidine kinase activity
E4188_02490	COG0784	Response regulator, receiver
E4188_02495	COG1879	ABC-type sugar transport system periplasmic component
E4188_02505	COG0745	RESPONSE REGULATOR receiver
E4188_02510	COG3005	denitrification pathway
E4188_02520	COG3381	protein complex oligomerization
E4188_02540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4188_02545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4188_02550	COG0511	ligase activity, forming carbon-carbon bonds
E4188_02555	COG0439	Biotin carboxylase
E4188_02560	COG3924	membrane
E4188_02565	COG4145	pantothenate transmembrane transporter activity
E4188_02570	COG1263	PTS System
E4188_02570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_02570	COG2190	(PTS) system
E4188_02575	COG0583	DNA-binding transcription factor activity
E4188_02580	COG0604	alcohol dehydrogenase
E4188_02585	COG2264	protein methyltransferase activity
E4188_02595	COG0778	Nitroreductase
E4188_02600	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_02600	COG1902	pentaerythritol trinitrate reductase activity
E4188_02605	COG0616	signal peptide processing
E4188_02625	COG3139	Protein of unknown function (DUF1315)
E4188_02630	COG0252	asparaginase activity
E4188_02635	COG0786	glutamate:sodium symporter activity
E4188_02645	COG5001	Diguanylate cyclase
E4188_02660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4188_02665	COG0384	phenazine biosynthesis protein PhzF
E4188_02670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4188_02675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_02680	COG0175	sulfate reduction
E4188_02685	COG2113	Glycine betaine
E4188_02690	COG4176	ABC-type proline glycine betaine transport system permease component
E4188_02695	COG4175	Glycine betaine
E4188_02705	COG3610	response to peptide
E4188_02710	COG2966	Psort location CytoplasmicMembrane, score
E4188_02720	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4188_02730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_02735	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_02745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_02795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_02800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_02850	COG2313	pseudouridylate synthase activity
E4188_02855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_02860	COG2146	nitrite reductase [NAD(P)H] activity
E4188_02860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_02865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_02865	COG2146	nitrite reductase [NAD(P)H] activity
E4188_02870	COG1116	anion transmembrane transporter activity
E4188_02875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4188_02880	COG1116	anion transmembrane transporter activity
E4188_02880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4188_02895	COG0243	molybdopterin cofactor binding
E4188_02920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4188_02940	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4188_02955	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4188_02965	COG4608	Belongs to the ABC transporter superfamily
E4188_02980	COG4239	(ABC) transporter, permease
E4188_02985	COG4174	ABC transporter (Permease)
E4188_02990	COG4206	TonB-dependent receptor
E4188_03000	COG0811	peptide transport
E4188_03005	COG0811	peptide transport
E4188_03010	COG0848	biopolymer transport protein
E4188_03055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_03060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_03065	COG0840	transmembrane signaling receptor activity
E4188_03075	COG1278	Cold shock
E4188_03115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4188_03125	COG0688	phosphatidylethanolamine metabolic process
E4188_03130	COG4628	conserved protein (DUF2132)
E4188_03145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_03150	COG2207	Transcriptional regulator
E4188_03160	COG3300	MHYT domain
E4188_03160	COG5001	Diguanylate cyclase
E4188_03165	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4188_03175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_03185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4188_03190	COG2017	converts alpha-aldose to the beta-anomer
E4188_03200	COG1609	Transcriptional regulator
E4188_03220	COG3039	Transposase
E4188_03225	COG0583	DNA-binding transcription factor activity
E4188_03250	COG1132	(ABC) transporter
E4188_03260	COG2897	thiosulfate sulfurtransferase activity
E4188_03265	COG2066	Belongs to the glutaminase family
E4188_03270	COG3171	Protein conserved in bacteria
E4188_03275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4188_03280	COG2234	aminopeptidase activity
E4188_03280	COG4935	Belongs to the peptidase S8 family
E4188_03285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_03290	COG2200	EAL domain
E4188_03295	COG1090	epimerase
E4188_03300	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4188_03305	COG4181	ATPase activity
E4188_03310	COG2755	lipolytic protein G-D-S-L family
E4188_03315	COG0784	Response regulator, receiver
E4188_03315	COG0835	chemotaxis
E4188_03320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4188_03325	COG0517	IMP dehydrogenase activity
E4188_03330	COG0488	(ABC) transporter
E4188_03340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4188_03370	COG3039	Transposase
E4188_03395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4188_03400	COG1376	ErfK ybiS ycfS ynhG family protein
E4188_03405	COG0668	transmembrane transport
E4188_03415	COG2731	YhcH YjgK YiaL family protein
E4188_03425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_03430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_03440	COG0583	DNA-binding transcription factor activity
E4188_03445	COG0477	Major facilitator Superfamily
E4188_03455	COG2985	domain, Protein
E4188_03455	COG0569	domain protein
E4188_03460	COG1272	protein, Hemolysin III
E4188_03465	COG0076	glutamate decarboxylase activity
E4188_03470	COG2917	probably involved in intracellular septation
E4188_03475	COG2350	Protein conserved in bacteria
E4188_03485	COG1555	photosystem II stabilization
E4188_03490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4188_03495	COG3104	oligopeptide transport
E4188_03500	COG0745	RESPONSE REGULATOR receiver
E4188_03530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_03560	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_03570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4188_03595	COG0732	type I restriction modification DNA specificity domain
E4188_03605	COG1484	DNA-dependent DNA replication
E4188_03610	COG4584	PFAM Integrase catalytic
E4188_03625	COG3293	Transposase
E4188_03670	COG5433	transposase activity
E4188_03740	COG2003	Belongs to the UPF0758 family
E4188_03790	COG3311	Transcriptional regulator
E4188_03850	COG0316	Belongs to the HesB IscA family
E4188_03860	COG0038	chloride channel
E4188_03865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4188_03880	COG0671	phosphoesterase, PA-phosphatase related
E4188_03890	COG0583	DNA-binding transcription factor activity
E4188_03895	COG2076	Multidrug Resistance protein
E4188_03910	COG0346	lactoylglutathione lyase activity
E4188_03915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4188_03920	COG1643	Atp-dependent helicase
E4188_03925	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4188_03930	COG1489	DNA binding
E4188_03935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4188_03940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_03945	COG0617	tRNA 3'-terminal CCA addition
E4188_03955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4188_03960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4188_03970	COG0842	Transport permease protein
E4188_03975	COG1131	(ABC) transporter
E4188_03990	COG0163	prenyltransferase activity
E4188_03995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4188_04000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4188_04015	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4188_04030	COG1136	(ABC) transporter
E4188_04065	COG3039	Transposase
E4188_04075	COG0529	Catalyzes the synthesis of activated sulfate
E4188_04080	COG0471	metal ion transport
E4188_04080	COG3273	potassium ion transport
E4188_04085	COG2895	sulfate adenylyltransferase (ATP) activity
E4188_04090	COG0175	sulfate reduction
E4188_04095	COG1648	precorrin-2 dehydrogenase activity
E4188_04095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4188_04100	COG0330	HflC and HflK could
E4188_04105	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4188_04115	COG0673	inositol 2-dehydrogenase activity
E4188_04125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4188_04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4188_04135	COG3036	rescue of stalled ribosome
E4188_04150	COG0138	bifunctional purine biosynthesis protein purh
E4188_04155	COG0151	Belongs to the GarS family
E4188_04180	COG4584	PFAM Integrase catalytic
E4188_04185	COG1484	DNA-dependent DNA replication
E4188_04195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4188_04200	COG0358	DNA primase activity
E4188_04205	COG1610	YqeY-like protein
E4188_04210	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4188_04215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4188_04225	COG1388	LysM domain
E4188_04225	COG4942	peptidase
E4188_04230	COG1238	metal cluster binding
E4188_04235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4188_04240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4188_04245	COG0585	pseudouridine synthase activity
E4188_04255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4188_04260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4188_04265	COG0148	phosphopyruvate hydratase activity
E4188_04270	COG0504	CTP synthase activity
E4188_04275	COG3956	TIGRFAM MazG family protein
E4188_04280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4188_04285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_04295	COG4807	Protein conserved in bacteria
E4188_04300	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4188_04305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4188_04310	COG1381	Involved in DNA repair and RecF pathway recombination
E4188_04320	COG0571	ribonuclease III activity
E4188_04325	COG0681	Belongs to the peptidase S26 family
E4188_04330	COG0481	GTPase activity
E4188_04350	COG1595	DNA-templated transcription, initiation
E4188_04355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4188_04405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_04410	COG0191	fructose-bisphosphate aldolase activity
E4188_04415	COG0126	phosphoglycerate kinase activity
E4188_04420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_04425	COG1940	carbohydrate kinase activity
E4188_04430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4188_04440	COG4991	sh3 domain protein
E4188_04445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4188_04460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4188_04470	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_04475	COG2982	Protein involved in outer membrane biogenesis
E4188_04480	COG1505	serine-type exopeptidase activity
E4188_04485	COG3174	membrane
E4188_04490	COG0110	maltose O-acetyltransferase activity
E4188_04505	COG3039	Transposase
E4188_04515	COG0165	Argininosuccinate lyase
E4188_04520	COG0137	argininosuccinate synthase activity
E4188_04530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4188_04535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4188_04545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4188_04550	COG5002	protein histidine kinase activity
E4188_04550	COG5001	Diguanylate cyclase
E4188_04550	COG3447	MASE1 domain protein
E4188_04585	COG0583	DNA-binding transcription factor activity
E4188_04590	COG1380	Effector of murein hydrolase LrgA
E4188_04595	COG1346	cytolysis
E4188_04600	COG0527	aspartate kinase activity
E4188_04600	COG0460	homoserine dehydrogenase
E4188_04605	COG0626	cystathionine gamma-synthase activity
E4188_04620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_04625	COG0814	amino acid
E4188_04630	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4188_04635	COG0494	nUDIX hydrolase
E4188_04640	COG1011	Hydrolase
E4188_04645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4188_04660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4188_04670	COG3156	type II secretion system protein K
E4188_04690	COG4795	General secretion pathway protein
E4188_04695	COG2165	general secretion pathway protein
E4188_04705	COG2165	general secretion pathway protein
E4188_04710	COG1459	type II secretion system
E4188_04715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_04725	COG3031	protein transport across the cell outer membrane
E4188_04735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4188_04740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4188_04760	COG3133	Outer membrane lipoprotein
E4188_04770	COG1392	Phosphate transport regulator
E4188_04775	COG0306	phosphate transporter
E4188_04780	COG0617	tRNA 3'-terminal CCA addition
E4188_04785	COG3267	Type II secretory pathway component ExeA
E4188_04785	COG3409	Peptidoglycan-binding domain 1 protein
E4188_04795	COG1194	a g-specific adenine glycosylase
E4188_04800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4188_04815	COG3240	lipase activity
E4188_04825	COG3009	Protein conserved in bacteria
E4188_04830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4188_04830	COG3008	intermembrane lipid transfer
E4188_04845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_04850	COG5001	Diguanylate cyclase
E4188_04850	COG4251	negative regulation of phosphorylation
E4188_04850	COG3706	GGDEF domain
E4188_04850	COG2203	Gaf domain
E4188_04855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4188_04860	COG2813	Specifically methylates the guanine in position
E4188_04865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4188_04870	COG0297	glycogen (starch) synthase activity
E4188_04910	COG1757	Na H antiporter
E4188_04915	COG0583	DNA-binding transcription factor activity
E4188_04920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4188_04925	COG3842	ATPase activity
E4188_04930	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_04935	COG1177	transmembrane transport
E4188_04940	COG1012	belongs to the aldehyde dehydrogenase family
E4188_04945	COG0109	protoheme IX farnesyltransferase activity
E4188_04950	COG1612	heme a metabolic process
E4188_04975	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4188_04980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4188_04985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4188_04990	COG1444	tRNA N-acetyltransferase activity
E4188_05010	COG1803	Methylglyoxal synthase
E4188_05025	COG0252	asparaginase activity
E4188_05035	COG1609	Transcriptional regulator
E4188_05045	COG1940	carbohydrate kinase activity
E4188_05050	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4188_05055	COG2723	6-phospho-beta-galactosidase activity
E4188_05060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_05060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_05065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_05070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_05085	COG1263	PTS System
E4188_05085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_05090	COG0366	Alpha amylase catalytic
E4188_05095	COG0110	maltose O-acetyltransferase activity
E4188_05100	COG1522	sequence-specific DNA binding
E4188_05105	COG5006	permease, DMT superfamily
E4188_05155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4188_05160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4188_05175	COG0477	Major facilitator Superfamily
E4188_05180	COG0523	cobalamin synthesis protein
E4188_05190	COG1280	lysine exporter protein (LysE YggA)
E4188_05200	COG2200	EAL domain
E4188_05205	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4188_05210	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4188_05215	COG0840	transmembrane signaling receptor activity
E4188_05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4188_05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4188_05245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4188_05250	COG2186	Transcriptional regulator
E4188_05290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_05295	COG1459	type II secretion system
E4188_05300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4188_05310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4188_05315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4188_05325	COG0653	protein targeting
E4188_05335	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4188_05340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4188_05345	COG0849	cell division
E4188_05350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4188_05355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4188_05360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4188_05365	COG0772	Belongs to the SEDS family
E4188_05370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4188_05375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4188_05380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4188_05385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4188_05390	COG0768	penicillin binding
E4188_05395	COG3116	cell division
E4188_05400	COG0275	rRNA processing
E4188_05405	COG2001	Belongs to the MraZ family
E4188_05415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4188_05420	COG3107	peptidoglycan biosynthetic process
E4188_05425	COG0792	nuclease activity
E4188_05430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4188_05435	COG2823	Periplasmic or secreted lipoprotein
E4188_05440	COG2969	positive regulation of protein catabolic process
E4188_05445	COG0625	glutathione transferase activity
E4188_05450	COG2857	Cytochrome c1
E4188_05455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4188_05460	COG0723	plastoquinol--plastocyanin reductase activity
E4188_05465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4188_05470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4188_05475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4188_05485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4188_05490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4188_05500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_05505	COG1660	Displays ATPase and GTPase activities
E4188_05510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_05525	COG1137	ATPase activity
E4188_05530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4188_05535	COG3117	lipopolysaccharide transmembrane transporter activity
E4188_05540	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4188_05545	COG0517	IMP dehydrogenase activity
E4188_05545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4188_05550	COG1127	ABC transporter
E4188_05555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4188_05560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4188_05565	COG2854	intermembrane phospholipid transfer
E4188_05575	COG5007	Belongs to the BolA IbaG family
E4188_05580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4188_05585	COG0312	modulator of DNA gyrase
E4188_05590	COG3028	Belongs to the UPF0307 family
E4188_05600	COG2926	Belongs to the UPF0265 family
E4188_05630	COG1396	sequence-specific DNA binding
E4188_05635	COG3135	benzoate transporter
E4188_05645	COG1522	sequence-specific DNA binding
E4188_05655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4188_05665	COG1058	Belongs to the CinA family
E4188_05665	COG1546	Belongs to the CinA family
E4188_05670	COG1988	membrane-bound metal-dependent
E4188_05680	COG0561	phosphatase activity
E4188_05685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4188_05695	COG1011	Hydrolase
E4188_05710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4188_05715	COG0019	diaminopimelate decarboxylase activity
E4188_05725	COG1965	Belongs to the frataxin family
E4188_05730	COG0400	carboxylic ester hydrolase activity
E4188_05735	COG3072	Adenylate cyclase
E4188_05740	COG0181	hydroxymethylbilane synthase activity
E4188_05750	COG2959	enzyme of heme biosynthesis
E4188_05755	COG3071	HemY protein
E4188_05765	COG1494	fructose-1,6-bisphosphatase
E4188_05775	COG1247	-acetyltransferase
E4188_05795	COG0456	acetyltransferase
E4188_05800	COG1733	regulation of RNA biosynthetic process
E4188_05820	COG3932	Exopolysaccharide synthesis, ExoD
E4188_05825	COG3706	GGDEF domain
E4188_05835	COG0110	maltose O-acetyltransferase activity
E4188_05845	COG1943	Transposase
E4188_05850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4188_05855	COG2022	thiamine diphosphate biosynthetic process
E4188_05865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4188_05870	COG0352	thiamine-phosphate diphosphorylase activity
E4188_05875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4188_05895	COG0745	RESPONSE REGULATOR receiver
E4188_05900	COG0642	Histidine kinase
E4188_05905	COG0189	ligase activity
E4188_05935	COG2321	neutral zinc metallopeptidase
E4188_05945	COG0477	Major facilitator Superfamily
E4188_05960	COG0312	modulator of DNA gyrase
E4188_05965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_05970	COG3164	Protein of unknown function
E4188_05975	COG1530	ribonuclease E activity
E4188_05980	COG0424	maF-like protein
E4188_05985	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4188_05990	COG1792	Involved in formation and maintenance of cell shape
E4188_05995	COG1077	Cell shape determining protein MreB Mrl
E4188_06040	COG1459	type II secretion system
E4188_06045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_06065	COG5433	transposase activity
E4188_06100	COG2200	EAL domain
E4188_06105	COG0387	Pfam Sodium calcium exchanger
E4188_06115	COG2986	histidine ammonia-lyase
E4188_06120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4188_06125	COG0010	Belongs to the arginase family
E4188_06130	COG1228	amidohydrolase
E4188_06135	COG2188	Transcriptional regulator
E4188_06140	COG0288	reversible hydration of carbon dioxide
E4188_06150	COG2177	Part of the ABC transporter FtsEX involved in
E4188_06155	COG2884	Cell division ATP-binding protein ftsE
E4188_06160	COG0552	protein localization to endoplasmic reticulum
E4188_06165	COG0742	ribosomal rna small subunit methyltransferase
E4188_06195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4188_06200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_06210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_06220	COG2095	MarC family integral membrane protein
E4188_06230	COG1301	dicarboxylic acid transport
E4188_06255	COG3714	YhhN family
E4188_06275	COG1770	oligopeptidase
E4188_06290	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4188_06315	COG5433	transposase activity
E4188_06365	COG0203	ribosomal protein L17
E4188_06370	COG0202	RNA polymerase activity
E4188_06375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4188_06380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4188_06385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4188_06390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4188_06395	COG0201	protein transport
E4188_06400	COG0200	Binds to the 23S rRNA
E4188_06405	COG1841	ribosomal large subunit assembly
E4188_06410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4188_06415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4188_06420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4188_06425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4188_06430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4188_06435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4188_06440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4188_06445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4188_06450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4188_06455	COG0255	Belongs to the universal ribosomal protein uL29 family
E4188_06460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4188_06465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4188_06470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4188_06475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4188_06480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4188_06485	COG0089	rRNA binding
E4188_06490	COG0088	Forms part of the polypeptide exit tunnel
E4188_06495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4188_06500	COG0051	transcription antitermination factor activity, RNA binding
E4188_06510	COG2205	protein histidine kinase activity
E4188_06515	COG0745	RESPONSE REGULATOR receiver
E4188_06550	COG3344	reverse transcriptase
E4188_06555	COG3385	transposase activity
E4188_06585	COG5433	transposase activity
E4188_06605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06640	COG4584	PFAM Integrase catalytic
E4188_06645	COG1484	DNA-dependent DNA replication
E4188_06655	COG3706	GGDEF domain
E4188_06660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4188_06680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_06725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4188_06735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_06745	COG5433	transposase activity
E4188_06765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4188_06790	COG2183	response to ionizing radiation
E4188_06805	COG0596	Alpha beta hydrolase
E4188_06810	COG1040	competence protein
E4188_06815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4188_06815	COG0316	Belongs to the HesB IscA family
E4188_06820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4188_06825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4188_06830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_06835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4188_06840	COG4942	peptidase
E4188_06850	COG1609	Transcriptional regulator
E4188_06855	COG0800	Aldolase
E4188_06860	COG0129	dihydroxy-acid dehydratase activity
E4188_06865	COG3265	gluconokinase activity
E4188_06870	COG2610	gluconate transmembrane transporter activity
E4188_06875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4188_06885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4188_06895	COG0456	acetyltransferase
E4188_06905	COG1490	D-aminoacyl-tRNA deacylase activity
E4188_06910	COG1295	ribonuclease BN
E4188_06920	COG0174	glutamine synthetase
E4188_06930	COG3852	Histidine kinase
E4188_06940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4188_06945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4188_06955	COG3078	GTPase activator activity
E4188_06965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4188_06970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4188_06975	COG0408	coproporphyrinogen oxidase activity
E4188_06980	COG0009	L-threonylcarbamoyladenylate synthase
E4188_06985	COG0551	DNA topoisomerase type I activity
E4188_06990	COG2922	Belongs to the Smg family
E4188_06995	COG0758	DNA mediated transformation
E4188_07005	COG0242	peptide deformylase activity
E4188_07010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4188_07015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_07015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_07020	COG0569	domain protein
E4188_07025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_07030	COG1322	Protein conserved in bacteria
E4188_07050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_07060	COG0519	Catalyzes the synthesis of GMP from XMP
E4188_07060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4188_07075	COG1396	sequence-specific DNA binding
E4188_07080	COG1012	belongs to the aldehyde dehydrogenase family
E4188_07090	COG2962	Rard protein
E4188_07100	COG1280	lysine exporter protein (LysE YggA)
E4188_07105	COG2391	methyltransferase activity
E4188_07140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_07160	COG5433	transposase activity
E4188_07180	COG0210	DNA helicase
E4188_07225	COG0583	DNA-binding transcription factor activity
E4188_07250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4188_07255	COG0385	Bile acid
E4188_07260	COG0531	amino acid
E4188_07265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_07270	COG0531	amino acid
E4188_07275	COG2731	YhcH YjgK YiaL family protein
E4188_07280	COG3250	beta-galactosidase activity
E4188_07285	COG1609	Transcriptional regulator
E4188_07325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4188_07330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_07330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_07340	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4188_07345	COG3074	FtsZ-dependent cytokinesis
E4188_07355	COG1045	serine acetyltransferase
E4188_07365	COG0745	RESPONSE REGULATOR receiver
E4188_07370	COG2205	protein histidine kinase activity
E4188_07375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4188_07380	COG0534	Mate efflux family protein
E4188_07395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4188_07400	COG2937	Belongs to the GPAT DAPAT family
E4188_07405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4188_07410	COG3161	chorismate lyase activity
E4188_07415	COG1580	Controls the rotational direction of flagella during chemotaxis
E4188_07430	COG0604	alcohol dehydrogenase
E4188_07450	COG3307	-O-antigen
E4188_07455	COG0438	transferase activity, transferring glycosyl groups
E4188_07460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4188_07475	COG1063	alcohol dehydrogenase
E4188_07490	COG0210	DNA helicase
E4188_07495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4188_07500	COG2166	iron-sulfur cluster assembly
E4188_07505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4188_07540	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4188_07545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_07550	COG1739	Uncharacterized protein family UPF0029
E4188_07555	COG0006	proline dipeptidase activity
E4188_07560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4188_07565	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4188_07565	COG1024	Enoyl-CoA hydratase
E4188_07570	COG0183	Belongs to the thiolase family
E4188_07575	COG0745	RESPONSE REGULATOR receiver
E4188_07585	COG1653	transport
E4188_07595	COG0425	Belongs to the sulfur carrier protein TusA family
E4188_07600	COG0251	oxidation-reduction process
E4188_07605	COG2885	chlorophyll binding
E4188_07630	COG2818	Glycosylase
E4188_07635	COG0752	glycyl-tRNA synthetase alpha subunit
E4188_07640	COG0751	glycine-tRNA ligase activity
E4188_07670	COG0814	amino acid
E4188_07675	COG0814	amino acid
E4188_07680	COG3033	Beta-eliminating lyase
E4188_07690	COG0348	domain, Protein
E4188_07700	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_07705	COG0426	domain, Protein
E4188_07705	COG1773	rubredoxin
E4188_07710	COG3604	Transcriptional regulator
E4188_07715	COG1609	Transcriptional regulator
E4188_07755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_07770	COG2960	long-chain fatty acid transporting porin activity
E4188_07780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4188_07795	COG3118	belongs to the thioredoxin family
E4188_07800	COG0513	Belongs to the DEAD box helicase family
E4188_07805	COG0248	Ppx GppA phosphatase
E4188_07820	COG0742	ribosomal rna small subunit methyltransferase
E4188_07840	COG0084	hydrolase, TatD family'
E4188_07845	COG0805	protein transport
E4188_07850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_07855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_07860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4188_07865	COG3165	ubiquinone biosynthetic process from chorismate
E4188_07870	COG2226	methyltransferase
E4188_07875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4188_07880	COG0402	S-adenosylhomocysteine deaminase activity
E4188_07885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4188_07920	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4188_07925	COG0848	biopolymer transport protein
E4188_07930	COG0811	peptide transport
E4188_07935	COG0811	peptide transport
E4188_07945	COG2771	luxR family
E4188_07955	COG1205	dead DEAH box helicase
E4188_07955	COG1111	helicase
E4188_07970	COG3039	Transposase
E4188_08010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4188_08015	COG1349	DNA-binding transcription factor activity
E4188_08020	COG0745	RESPONSE REGULATOR receiver
E4188_08025	COG2205	protein histidine kinase activity
E4188_08040	COG4452	Inner membrane protein CreD
E4188_08045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4188_08050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4188_08055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4188_08060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4188_08065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4188_08070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4188_08075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4188_08085	COG0356	it plays a direct role in the translocation of protons across the membrane
E4188_08095	COG1475	DNA binding
E4188_08100	COG1192	Involved in chromosome partitioning
E4188_08105	COG0357	Ribosomal RNA small subunit methyltransferase G
E4188_08110	COG0445	tRNA wobble uridine modification
E4188_08115	COG0716	FMN binding
E4188_08120	COG4774	siderophore transport
E4188_08125	COG4615	Cyclic peptide transporter
E4188_08130	COG1120	ATPase activity
E4188_08135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_08140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_08150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4188_08155	COG0706	membrane insertase activity
E4188_08160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4188_08165	COG0594	ribonuclease P activity
E4188_08170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4188_08190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4188_08195	COG0592	DNA-directed DNA polymerase activity
E4188_08205	COG0187	DNA topoisomerase II activity
E4188_08215	COG2378	regulation of single-species biofilm formation
E4188_08225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4188_08230	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_08235	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_08240	COG3977	Valine--pyruvate aminotransferase
E4188_08255	COG2814	Major facilitator Superfamily
E4188_08260	COG0745	RESPONSE REGULATOR receiver
E4188_08265	COG2205	protein histidine kinase activity
E4188_08290	COG1733	regulation of RNA biosynthetic process
E4188_08295	COG2267	carboxylic ester hydrolase activity
E4188_08300	COG0604	alcohol dehydrogenase
E4188_08305	COG0300	oxidoreductase activity
E4188_08310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4188_08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_08315	COG4191	Histidine kinase
E4188_08320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_08325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_08330	COG1309	transcriptional regulator
E4188_08360	COG0561	phosphatase activity
E4188_08365	COG2267	carboxylic ester hydrolase activity
E4188_08370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4188_08375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4188_08380	COG1758	RNA polymerase activity
E4188_08395	COG0859	PFAM glycosyl transferase family 9
E4188_08400	COG3642	lipopolysaccharide core region biosynthetic process
E4188_08440	COG0589	response to stress
E4188_08445	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4188_08450	COG3706	GGDEF domain
E4188_08455	COG1528	Iron-storage protein
E4188_08460	COG2081	HI0933 family
E4188_08465	COG2223	nitrite transmembrane transporter activity
E4188_08475	COG3275	phosphorelay sensor kinase activity
E4188_08480	COG3279	Response regulator of the LytR AlgR family
E4188_08485	COG2223	nitrite transmembrane transporter activity
E4188_08490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4188_08500	COG4206	TonB-dependent receptor
E4188_08505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4188_08535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_08535	COG1042	CoA-binding domain protein
E4188_08535	COG0045	succinate-CoA ligase (ADP-forming) activity
E4188_08545	COG0583	DNA-binding transcription factor activity
E4188_08550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4188_08555	COG0166	Belongs to the GPI family
E4188_08565	COG0668	transmembrane transport
E4188_08570	COG1309	transcriptional regulator
E4188_08580	COG0756	dUTP diphosphatase activity
E4188_08585	COG3039	Transposase
E4188_08615	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_08620	COG1538	Outer membrane efflux protein
E4188_08625	COG1484	DNA-dependent DNA replication
E4188_08630	COG4584	PFAM Integrase catalytic
E4188_08650	COG0745	RESPONSE REGULATOR receiver
E4188_08700	COG2132	Multicopper oxidase
E4188_08715	COG3039	Transposase
E4188_08730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4188_08735	COG2003	Belongs to the UPF0758 family
E4188_08740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4188_08745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4188_08755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4188_08760	COG2990	Protein conserved in bacteria
E4188_08765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4188_08770	COG0859	PFAM glycosyl transferase family 9
E4188_08775	COG0463	Glycosyl transferase, family 2
E4188_08780	COG0859	PFAM glycosyl transferase family 9
E4188_08785	COG1519	Transferase
E4188_08795	COG1561	YicC-like family, N-terminal region
E4188_08800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4188_08805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4188_08815	COG0789	Transcriptional regulator
E4188_08820	COG5001	Diguanylate cyclase
E4188_08820	COG4251	negative regulation of phosphorylation
E4188_08820	COG3706	GGDEF domain
E4188_08820	COG2203	Gaf domain
E4188_08825	COG3084	Protein conserved in bacteria
E4188_08835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4188_08840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4188_08845	COG3639	organic phosphonate transmembrane transporter activity
E4188_08850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4188_08855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4188_08865	COG1335	isochorismatase
E4188_08875	COG1683	Conserved Protein
E4188_08880	COG0204	Acyl-transferase
E4188_08885	COG0204	Acyl-transferase
E4188_08890	COG0606	chelatase, subunit chli
E4188_08905	COG3978	acetolactate synthase activity
E4188_08915	COG0129	dihydroxy-acid dehydratase activity
E4188_08945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4188_08950	COG0254	rRNA binding
E4188_08955	COG0702	epimerase
E4188_08960	COG0281	malic enzyme
E4188_08970	COG2205	protein histidine kinase activity
E4188_08975	COG0745	RESPONSE REGULATOR receiver
E4188_08980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_08995	COG0366	Alpha amylase catalytic
E4188_09010	COG0443	Heat shock 70 kDa protein
E4188_09015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4188_09020	COG3045	CreA protein
E4188_09040	COG0174	glutamine synthetase
E4188_09060	COG3842	ATPase activity
E4188_09065	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_09070	COG1177	transmembrane transport
E4188_09075	COG2258	MOSC domain
E4188_09095	COG2050	protein possibly involved in aromatic compounds catabolism
E4188_09100	COG0514	ATP-dependent DNA helicase (RecQ)
E4188_09110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4188_09120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4188_09125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4188_09130	COG2239	Acts as a magnesium transporter
E4188_09135	COG1648	precorrin-2 dehydrogenase activity
E4188_09135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4188_09140	COG2116	formate transmembrane transporter activity
E4188_09155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_09160	COG0842	Transport permease protein
E4188_09165	COG0842	Transport permease protein
E4188_09170	COG1131	(ABC) transporter
E4188_09175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_09195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4188_09200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4188_09210	COG0018	arginyl-trna synthetase
E4188_09220	COG1595	DNA-templated transcription, initiation
E4188_09225	COG3806	Anti-sigma factor
E4188_09230	COG1968	undecaprenyl-diphosphatase activity
E4188_09235	COG0667	Aldo Keto reductase
E4188_09240	COG2017	converts alpha-aldose to the beta-anomer
E4188_09245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4188_09255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_09260	COG1609	Transcriptional regulator
E4188_09265	COG3250	beta-galactosidase activity
E4188_09280	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4188_09305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4188_09310	COG1288	antiporter activity
E4188_09315	COG1438	arginine binding
E4188_09320	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4188_09325	COG0540	Belongs to the ATCase OTCase family
E4188_09355	COG3040	lipid binding
E4188_09360	COG2207	Transcriptional regulator
E4188_09365	COG1979	alcohol dehydrogenase
E4188_09370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4188_09375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4188_09380	COG3681	Belongs to the UPF0597 family
E4188_09390	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_09395	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_09400	COG0564	pseudouridine synthase activity
E4188_09410	COG0542	response to heat
E4188_09415	COG2502	aspartate--ammonia ligase
E4188_09420	COG1522	sequence-specific DNA binding
E4188_09430	COG5413	integral membrane protein
E4188_09435	COG0517	IMP dehydrogenase activity
E4188_09435	COG0516	GMP reductase activity
E4188_09455	COG2205	protein histidine kinase activity
E4188_09465	COG2204	response regulator
E4188_09485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4188_09500	COG0745	RESPONSE REGULATOR receiver
E4188_09505	COG2205	protein histidine kinase activity
E4188_09515	COG0243	molybdopterin cofactor binding
E4188_09520	COG3005	denitrification pathway
E4188_09525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4188_09530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_09535	COG0569	domain protein
E4188_09540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4188_09565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4188_09580	COG0250	Participates in transcription elongation, termination and antitermination
E4188_09585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4188_09590	COG0081	regulation of translation
E4188_09595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4188_09600	COG0222	ribosome binding
E4188_09605	COG0085	RNA polymerase activity
E4188_09610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4188_09615	COG2964	Protein conserved in bacteria
E4188_09635	COG2168	tRNA wobble position uridine thiolation
E4188_09640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4188_09645	COG0049	tRNA binding
E4188_09650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4188_09655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4188_09660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4188_09695	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4188_09700	COG2252	PERMEase
E4188_09705	COG2376	Dihydroxyacetone kinase
E4188_09710	COG1461	Dihydroxyacetone kinase
E4188_09725	COG3284	Transcriptional regulator
E4188_09735	COG0628	permease
E4188_09760	COG0753	catalase activity
E4188_09765	COG0456	acetyltransferase
E4188_09765	COG0454	-acetyltransferase
E4188_09785	COG2203	Gaf domain
E4188_09785	COG2199	diguanylate cyclase activity
E4188_09795	COG3842	ATPase activity
E4188_09805	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_09830	COG0583	DNA-binding transcription factor activity
E4188_09840	COG1741	Belongs to the pirin family
E4188_09845	COG2259	Doxx family
E4188_09850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4188_09855	COG1074	ATP-dependent DNA helicase activity
E4188_09860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4188_09880	COG0346	lactoylglutathione lyase activity
E4188_09890	COG0004	ammonium transporteR
E4188_09895	COG0347	Belongs to the P(II) protein family
E4188_09900	COG3706	GGDEF domain
E4188_09920	COG0745	RESPONSE REGULATOR receiver
E4188_09925	COG2205	protein histidine kinase activity
E4188_09930	COG1278	Cold shock
E4188_09960	COG1396	sequence-specific DNA binding
E4188_09995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4188_10035	COG2197	response regulator
E4188_10040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4188_10045	COG3047	cAMP biosynthetic process
E4188_10095	COG4221	oxidoreductase activity
E4188_10110	COG1979	alcohol dehydrogenase
E4188_10120	COG2873	o-acetylhomoserine
E4188_10150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4188_10160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4188_10165	COG2949	membrane
E4188_10170	COG3291	Pkd domain containing protein
E4188_10175	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_10180	COG1441	menaquinone biosynthetic process
E4188_10185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4188_10190	COG0596	Alpha beta hydrolase
E4188_10195	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4188_10200	COG1169	isochorismate synthase
E4188_10205	COG1575	Belongs to the MenA family. Type 1 subfamily
E4188_10230	COG0513	Belongs to the DEAD box helicase family
E4188_10235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_10265	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_10270	COG1671	Belongs to the UPF0178 family
E4188_10295	COG3722	fumarate hydratase activity
E4188_10300	COG0246	Mannitol dehydrogenase
E4188_10305	COG2213	PTS system mannitol-specific
E4188_10305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_10310	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4188_10325	COG2771	luxR family
E4188_10340	COG1560	Kdo2-lipid A biosynthetic process
E4188_10345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4188_10345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4188_10350	COG1538	Outer membrane efflux protein
E4188_10355	COG0494	nUDIX hydrolase
E4188_10360	COG3151	Protein conserved in bacteria
E4188_10370	COG3150	esterase
E4188_10375	COG1051	belongs to the nudix hydrolase family
E4188_10465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_10485	COG0204	Acyl-transferase
E4188_10490	COG1842	Phage shock protein A
E4188_10505	COG2827	Endonuclease containing a URI domain
E4188_10510	COG2962	Rard protein
E4188_10515	COG1573	uracil-dna glycosylase
E4188_10525	COG0583	DNA-binding transcription factor activity
E4188_10530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4188_10535	COG1121	(ABC) transporter
E4188_10540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4188_10560	COG0739	heme binding
E4188_10570	COG3068	Protein conserved in bacteria
E4188_10590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4188_10600	COG1546	Belongs to the CinA family
E4188_10605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4188_10615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4188_10620	COG0527	aspartate kinase activity
E4188_10625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4188_10660	COG1686	Belongs to the peptidase S11 family
E4188_10665	COG0586	Pfam SNARE associated Golgi protein
E4188_10670	COG1253	flavin adenine dinucleotide binding
E4188_10685	COG2927	DNA polymerase III (CHI subunit)
E4188_10690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_10695	COG0795	lipopolysaccharide-transporting ATPase activity
E4188_10700	COG0795	lipopolysaccharide-transporting ATPase activity
E4188_10720	COG0004	ammonium transporteR
E4188_10725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_10745	COG0084	hydrolase, TatD family'
E4188_10750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_10760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4188_10765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4188_10770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4188_10785	COG3064	Membrane
E4188_10795	COG0560	Phosphoserine phosphatase
E4188_10810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4188_10820	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4188_10825	COG0776	regulation of translation
E4188_10840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4188_10845	COG0735	belongs to the Fur family
E4188_10865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4188_10870	COG0513	Belongs to the DEAD box helicase family
E4188_10875	COG3022	response to hydroperoxide
E4188_10890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4188_10895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4188_10900	COG0762	integral membrane protein
E4188_10905	COG1872	DUF167
E4188_10925	COG3112	Uncharacterised protein family (UPF0231)
E4188_10930	COG3835	regulator
E4188_10935	COG2610	gluconate transmembrane transporter activity
E4188_10940	COG1929	Belongs to the glycerate kinase type-1 family
E4188_10955	COG0583	DNA-binding transcription factor activity
E4188_10960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_10975	COG0347	Belongs to the P(II) protein family
E4188_10980	COG1840	ABC-type Fe3 transport system, periplasmic component
E4188_10990	COG3842	ATPase activity
E4188_10995	COG2837	iron assimilation
E4188_11000	COG1438	arginine binding
E4188_11005	COG1126	abc transporter atp-binding protein
E4188_11010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_11015	COG4215	(ABC) transporter
E4188_11020	COG4160	amino acid transport
E4188_11025	COG0039	L-malate dehydrogenase activity
E4188_11035	COG1017	nitric oxide dioxygenase activity
E4188_11035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_11045	COG4536	flavin adenine dinucleotide binding
E4188_11050	COG4137	Cytochrome C assembly protein
E4188_11055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4188_11060	COG0228	four-way junction DNA binding
E4188_11065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4188_11070	COG0336	Belongs to the RNA methyltransferase TrmD family
E4188_11075	COG0335	large ribosomal subunit rRNA binding
E4188_11090	COG1051	belongs to the nudix hydrolase family
E4188_11100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4188_11110	COG4974	Belongs to the 'phage' integrase family
E4188_11135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4188_11140	COG3039	Transposase
E4188_11150	COG2194	sulfuric ester hydrolase activity
E4188_11160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4188_11165	COG5642	Protein of unknown function (DUF2384)
E4188_11200	COG5433	transposase activity
E4188_11230	COG4584	PFAM Integrase catalytic
E4188_11235	COG1484	DNA-dependent DNA replication
E4188_11250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4188_11260	COG0583	DNA-binding transcription factor activity
E4188_11265	COG0640	Transcriptional regulator
E4188_11270	COG0268	Binds directly to 16S ribosomal RNA
E4188_11275	COG0728	peptidoglycan biosynthetic process
E4188_11280	COG0196	riboflavin kinase activity
E4188_11285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4188_11290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4188_11295	COG1047	Peptidyl-prolyl cis-trans
E4188_11300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4188_11330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_11330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4188_11345	COG1854	S-ribosylhomocysteine lyase activity
E4188_11350	COG3706	GGDEF domain
E4188_11355	COG0557	exoribonuclease II activity
E4188_11360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4188_11370	COG2153	protein acetylation
E4188_11385	COG1914	H( )-stimulated, divalent metal cation uptake system
E4188_11390	COG0360	Binds together with S18 to 16S ribosomal RNA
E4188_11395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4188_11400	COG0359	binds to the 23S rRNA
E4188_11430	COG1064	alcohol dehydrogenase
E4188_11435	COG1238	metal cluster binding
E4188_11440	COG0612	Peptidase, M16
E4188_11445	COG2918	glutathione biosynthetic process
E4188_11450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4188_11455	COG1027	Aspartate ammonia-lyase
E4188_11460	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4188_11465	COG0534	Mate efflux family protein
E4188_11470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4188_11475	COG0459	protein refolding
E4188_11495	COG0564	pseudouridine synthase activity
E4188_11500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4188_11530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4188_11540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4188_11545	COG4208	sulfate ABC transporter
E4188_11550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4188_11555	COG0583	DNA-binding transcription factor activity
E4188_11565	COG3397	chitin binding
E4188_11570	COG0840	transmembrane signaling receptor activity
E4188_11595	COG1328	CTP reductase activity
E4188_11600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4188_11615	COG1448	Aminotransferase
E4188_11640	COG1215	transferase activity, transferring glycosyl groups
E4188_11650	COG0457	Tetratricopeptide repeat
E4188_11650	COG3118	belongs to the thioredoxin family
E4188_11685	COG0513	Belongs to the DEAD box helicase family
E4188_11705	COG0840	transmembrane signaling receptor activity
E4188_11715	COG4166	transmembrane transport
E4188_11730	COG1024	Enoyl-CoA hydratase
E4188_11745	COG4221	oxidoreductase activity
E4188_11750	COG0442	prolyl-tRNA aminoacylation
E4188_11755	COG0632	four-way junction helicase activity
E4188_11760	COG2255	four-way junction helicase activity
E4188_11770	COG1271	oxidase subunit
E4188_11775	COG1294	oxidase, subunit
E4188_11780	COG4890	Cyd operon protein YbgT
E4188_11785	COG3790	cyd operon protein YbgE
E4188_11790	COG0824	Thioesterase
E4188_11795	COG0811	peptide transport
E4188_11810	COG0823	Involved in the tonB-independent uptake of proteins
E4188_11815	COG2885	chlorophyll binding
E4188_11820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4188_11895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4188_11905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_11910	COG1640	4-alpha-glucanotransferase
E4188_11915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4188_11940	COG2130	NADP-dependent
E4188_11945	COG1846	Transcriptional regulator
E4188_11975	COG0561	phosphatase activity
E4188_11990	COG0733	neurotransmitter:sodium symporter activity
E4188_11995	COG0733	neurotransmitter:sodium symporter activity
E4188_12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_12025	COG1794	racemase activity, acting on amino acids and derivatives
E4188_12035	COG1022	Amp-dependent synthetase and ligase
E4188_12045	COG0456	acetyltransferase
E4188_12060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4188_12065	COG5001	Diguanylate cyclase
E4188_12065	COG3300	MHYT domain
E4188_12075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4188_12085	COG1902	pentaerythritol trinitrate reductase activity
E4188_12105	COG2957	Belongs to the agmatine deiminase family
E4188_12110	COG0154	amidase activity
E4188_12120	COG3039	Transposase
E4188_12140	COG0513	Belongs to the DEAD box helicase family
E4188_12145	COG3706	GGDEF domain
E4188_12155	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4188_12220	COG1484	DNA-dependent DNA replication
E4188_12225	COG4584	PFAM Integrase catalytic
E4188_12240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4188_12245	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4188_12250	COG1178	ABC-type Fe3 transport system permease component
E4188_12255	COG4143	(ABC) transporter
E4188_12270	COG0066	3-isopropylmalate dehydratase activity
E4188_12275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4188_12280	COG0473	3-isopropylmalate dehydrogenase activity
E4188_12285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4188_12295	COG0671	phosphoesterase, PA-phosphatase related
E4188_12300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4188_12310	COG0028	Belongs to the TPP enzyme family
E4188_12315	COG0440	acetolactate synthase activity
E4188_12320	COG0857	belongs to the CobB CobQ family
E4188_12320	COG0280	phosphate acetyltransferase
E4188_12325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4188_12335	COG3013	Belongs to the UPF0304 family
E4188_12340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4188_12345	COG2716	regulation of RNA biosynthetic process
E4188_12350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4188_12355	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4188_12360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4188_12395	COG0784	Response regulator, receiver
E4188_12395	COG2198	Histidine kinase
E4188_12395	COG5002	protein histidine kinase activity
E4188_12400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4188_12440	COG0840	transmembrane signaling receptor activity
E4188_12450	COG1464	Belongs to the NlpA lipoprotein family
E4188_12455	COG2011	ABC-type metal ion transport system permease component
E4188_12460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4188_12480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4188_12480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4188_12485	COG0802	atpase or kinase
E4188_12495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4188_12500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4188_12505	COG1923	regulation of RNA biosynthetic process
E4188_12510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4188_12515	COG0330	HflC and HflK could
E4188_12520	COG0330	HflC and HflK could
E4188_12525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4188_12530	COG0142	geranyltranstransferase activity
E4188_12535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4188_12540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4188_12545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4188_12555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4188_12560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4188_12570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4188_12575	COG2967	ApaG domain
E4188_12580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4188_12585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4188_12595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4188_12600	COG3178	'Phosphotransferase
E4188_12605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4188_12610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4188_12620	COG2252	PERMEase
E4188_12630	COG0488	(ABC) transporter
E4188_12635	COG0741	lytic transglycosylase activity
E4188_12640	COG0463	Glycosyl transferase, family 2
E4188_12650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4188_12675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_12685	COG3721	Heme iron utilization protein
E4188_12690	COG0748	coenzyme F420 binding
E4188_12715	COG2814	Major facilitator Superfamily
E4188_12720	COG2205	protein histidine kinase activity
E4188_12750	COG1765	OsmC-like protein
E4188_12765	COG3954	Phosphoribulokinase
E4188_12770	COG3089	Belongs to the UPF0270 family
E4188_12780	COG0429	hydrolase of the alpha beta-hydrolase fold
E4188_12785	COG0784	Response regulator, receiver
E4188_12785	COG0835	chemotaxis
E4188_12795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4188_12800	COG1047	Peptidyl-prolyl cis-trans
E4188_12815	COG0545	Peptidyl-prolyl cis-trans isomerase
E4188_12840	COG0737	Belongs to the 5'-nucleotidase family
E4188_12860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4188_12865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4188_12865	COG0506	proline dehydrogenase activity
E4188_12865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4188_12875	COG0114	fumarate hydratase activity
E4188_12915	COG2203	Gaf domain
E4188_12915	COG2200	EAL domain
E4188_12915	COG2199	diguanylate cyclase activity
E4188_12950	COG1280	lysine exporter protein (LysE YggA)
E4188_12960	COG0826	peptidase U32
E4188_12970	COG3813	Protein conserved in bacteria
E4188_12990	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4188_13015	COG0300	oxidoreductase activity
E4188_13035	COG2610	gluconate transmembrane transporter activity
E4188_13040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4188_13045	COG3622	Belongs to the hyi family
E4188_13050	COG0235	Class ii aldolase
E4188_13055	COG3395	kinase activity
E4188_13060	COG2084	Dehydrogenase
E4188_13065	COG1349	DNA-binding transcription factor activity
E4188_13075	COG2133	pyrroloquinoline quinone binding
E4188_13090	COG1609	Transcriptional regulator
E4188_13110	COG1175	transmembrane transport
E4188_13125	COG3940	Belongs to the glycosyl hydrolase 43 family
E4188_13140	COG4580	involved in the transport of maltose and maltodextrins
E4188_13145	COG5433	transposase activity
E4188_13150	COG4580	involved in the transport of maltose and maltodextrins
E4188_13175	COG0077	Prephenate dehydratase
E4188_13175	COG1605	Chorismate mutase
E4188_13200	COG3272	Protein of unknown function (DUF1722)
E4188_13205	COG0789	Transcriptional regulator
E4188_13210	COG0415	Belongs to the DNA photolyase family
E4188_13220	COG0300	oxidoreductase activity
E4188_13235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4188_13260	COG0783	Belongs to the Dps family
E4188_13265	COG1151	hydroxylamine reductase activity
E4188_13270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_13275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_13305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_13315	COG0798	PFAM Bile acid sodium symporter
E4188_13320	COG1393	Belongs to the ArsC family
E4188_13350	COG0659	secondary active sulfate transmembrane transporter activity
E4188_13355	COG2771	luxR family
E4188_13370	COG3501	Rhs element vgr protein
E4188_13385	COG3039	Transposase
E4188_13410	COG1666	GTP binding
E4188_13415	COG3248	Nucleoside-binding outer membrane protein
E4188_13420	COG2211	Major facilitator Superfamily
E4188_13430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4188_13440	COG2813	Specifically methylates the guanine in position
E4188_13445	COG0271	Belongs to the BolA IbaG family
E4188_13450	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_13455	COG1805	sodium ion transport
E4188_13460	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_13465	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_13470	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_13475	COG2871	sodium ion transport
E4188_13480	COG1477	protein flavinylation
E4188_13495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4188_13500	COG0840	transmembrane signaling receptor activity
E4188_13505	COG0583	DNA-binding transcription factor activity
E4188_13515	COG2363	Small membrane protein
E4188_13520	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4188_13530	COG0473	3-isopropylmalate dehydrogenase activity
E4188_13535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_13540	COG1611	Belongs to the LOG family
E4188_13545	COG3706	GGDEF domain
E4188_13555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4188_13555	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4188_13565	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4188_13590	COG3098	single-species biofilm formation
E4188_13595	COG0564	pseudouridine synthase activity
E4188_13605	COG4580	involved in the transport of maltose and maltodextrins
E4188_13615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_13615	COG1263	PTS System
E4188_13625	COG2171	N-acyltransferase activity
E4188_13630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4188_13635	COG0024	Methionine aminopeptidase
E4188_13640	COG0052	Belongs to the universal ribosomal protein uS2 family
E4188_13645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4188_13650	COG0528	UMP kinase activity
E4188_13655	COG0233	cytoplasmic translational termination
E4188_13660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4188_13665	COG0575	Belongs to the CDS family
E4188_13670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4188_13675	COG0750	zinc metalloprotease
E4188_13690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_13695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4188_13700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_13705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_13710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4188_13720	COG0825	malonyl-CoA metabolic process
E4188_13730	COG0583	DNA-binding transcription factor activity
E4188_13735	COG0814	amino acid
E4188_13740	COG0531	amino acid
E4188_13760	COG3590	peptidase
E4188_13770	COG3706	GGDEF domain
E4188_13810	COG0366	Alpha amylase catalytic
E4188_13825	COG0463	Glycosyl transferase, family 2
E4188_13840	COG2989	Protein conserved in bacteria
E4188_13845	COG3108	Peptidase M15
E4188_13855	COG2860	membrane
E4188_13865	COG1196	nuclear chromosome segregation
E4188_13870	COG3115	cell septum assembly
E4188_13875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4188_13885	COG1328	CTP reductase activity
E4188_13890	COG0602	queuosine metabolic process
E4188_13915	COG1566	PFAM secretion protein HlyD family protein
E4188_13930	COG0281	malic enzyme
E4188_13935	COG3290	protein histidine kinase activity
E4188_13945	COG0697	spore germination
E4188_13955	COG1012	belongs to the aldehyde dehydrogenase family
E4188_13960	COG3284	Transcriptional regulator
E4188_13965	COG3706	GGDEF domain
E4188_13970	COG3039	Transposase
E4188_13975	COG0346	lactoylglutathione lyase activity
E4188_13980	COG0745	RESPONSE REGULATOR receiver
E4188_13985	COG5002	protein histidine kinase activity
E4188_13995	COG4783	chaperone-mediated protein folding
E4188_14005	COG1940	carbohydrate kinase activity
E4188_14010	COG3142	Participates in the control of copper homeostasis
E4188_14015	COG0545	Peptidyl-prolyl cis-trans isomerase
E4188_14020	COG1131	(ABC) transporter
E4188_14035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_14040	COG4597	amino acid ABC transporter
E4188_14045	COG0765	amino acid transport
E4188_14050	COG1126	abc transporter atp-binding protein
E4188_14060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4188_14065	COG0678	peroxiredoxin activity
E4188_14075	COG0019	diaminopimelate decarboxylase activity
E4188_14080	COG1115	amino acid carrier protein
E4188_14085	COG0095	Lipoate-protein ligase
E4188_14090	COG2233	PERMEase
E4188_14105	COG0534	Mate efflux family protein
E4188_14115	COG0281	malic enzyme
E4188_14145	COG0733	neurotransmitter:sodium symporter activity
E4188_14150	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4188_14155	COG3706	GGDEF domain
E4188_14170	COG1032	radical SAM domain protein
E4188_14180	COG5433	transposase activity
E4188_14215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_14230	COG0673	inositol 2-dehydrogenase activity
E4188_14235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4188_14240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4188_14245	COG1196	nuclear chromosome segregation
E4188_14245	COG0741	lytic transglycosylase activity
E4188_14245	COG0739	heme binding
E4188_14270	COG0788	formyltetrahydrofolate deformylase activity
E4188_14275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4188_14285	COG3118	belongs to the thioredoxin family
E4188_14295	COG0791	NLP P60 protein
E4188_14300	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4188_14315	COG1388	LysM domain
E4188_14315	COG1376	ErfK ybiS ycfS ynhG family protein
E4188_14335	COG0348	domain, Protein
E4188_14335	COG3901	Regulator of nitric oxide reductase transcription
E4188_14340	COG4263	nitrous-oxide reductase activity
E4188_14355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4188_14365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_14440	COG0784	Response regulator, receiver
E4188_14440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_14440	COG2198	Histidine kinase
E4188_14440	COG2205	protein histidine kinase activity
E4188_14445	COG4584	PFAM Integrase catalytic
E4188_14450	COG1484	DNA-dependent DNA replication
E4188_14460	COG3384	dioxygenase
E4188_14470	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4188_14480	COG0531	amino acid
E4188_14490	COG0531	amino acid
E4188_14505	COG1917	Cupin 2, conserved barrel domain protein
E4188_14505	COG1396	sequence-specific DNA binding
E4188_14510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_14525	COG2974	May be involved in recombination
E4188_14530	COG0456	acetyltransferase
E4188_14535	COG0420	3'-5' exonuclease activity
E4188_14545	COG3038	cytochrome b561
E4188_14550	COG2190	(PTS) system
E4188_14560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_14565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4188_14570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4188_14585	COG1720	tRNA m6t6A37 methyltransferase activity
E4188_14605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4188_14610	COG4988	ABC transporter
E4188_14625	COG0745	RESPONSE REGULATOR receiver
E4188_14635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4188_14670	COG3153	acetyltransferase
E4188_14690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4188_14695	COG2867	negative regulation of translational initiation
E4188_14720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_14730	COG0564	pseudouridine synthase activity
E4188_14760	COG1280	lysine exporter protein (LysE YggA)
E4188_14775	COG3263	regulation of cellular component size
E4188_14785	COG1876	peptidase activity
E4188_14790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4188_14795	COG1393	Belongs to the ArsC family
E4188_14810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4188_14820	COG1902	pentaerythritol trinitrate reductase activity
E4188_14830	COG3321	synthase
E4188_14830	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_14830	COG0604	alcohol dehydrogenase
E4188_14835	COG0017	Asparaginyl-tRNA synthetase
E4188_14855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4188_14860	COG0156	8-amino-7-oxononanoate synthase activity
E4188_14865	COG1073	alpha beta
E4188_14865	COG2226	methyltransferase
E4188_14870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4188_14875	COG0501	Belongs to the peptidase M48B family
E4188_14880	COG0633	Ferredoxin
E4188_14880	COG3217	Mosc domain protein beta barrel domain protein
E4188_14880	COG0633	Ferredoxin
E4188_14880	COG3217	Mosc domain protein beta barrel domain protein
E4188_14890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4188_14890	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4188_14890	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4188_14890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4188_14900	COG2841	Protein conserved in bacteria
E4188_14910	COG0534	Mate efflux family protein
E4188_14945	COG1309	transcriptional regulator
E4188_14960	COG0791	NLP P60 protein
E4188_14965	COG0583	DNA-binding transcription factor activity
E4188_14985	COG0500	methyltransferase
E4188_14990	COG4106	trans-aconitate 2-methyltransferase activity
E4188_14995	COG1801	Protein of unknown function DUF72
E4188_15005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4188_15010	COG0217	transcriptional regulatory protein
E4188_15020	COG1846	Transcriptional regulator
E4188_15020	COG1940	carbohydrate kinase activity
E4188_15025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4188_15030	COG0363	glucosamine-6-phosphate deaminase activity
E4188_15035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_15035	COG2190	(PTS) system
E4188_15035	COG1263	PTS System
E4188_15045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_15050	COG0735	belongs to the Fur family
E4188_15060	COG0716	FMN binding
E4188_15075	COG0596	Alpha beta hydrolase
E4188_15080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4188_15085	COG0033	Phosphoglucomutase
E4188_15095	COG1846	Transcriptional regulator
E4188_15100	COG2951	lytic endotransglycosylase activity
E4188_15105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4188_15110	COG4136	ATPase activity
E4188_15120	COG4134	Bacterial extracellular solute-binding protein
E4188_15130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_15140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4188_15150	COG0729	surface antigen
E4188_15175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4188_15185	COG0741	lytic transglycosylase activity
E4188_15200	COG1607	acyl-coa hydrolase
E4188_15215	COG1388	LysM domain
E4188_15215	COG0741	lytic transglycosylase activity
E4188_15220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4188_15225	COG2226	methyltransferase
E4188_15230	COG0328	RNA-DNA hybrid ribonuclease activity
E4188_15235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_15245	COG3437	response regulator, receiver
E4188_15245	COG0784	Response regulator, receiver
E4188_15250	COG1960	acyl-CoA dehydrogenase activity
E4188_15255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4188_15260	COG0121	glutamine amidotransferase
E4188_15270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4188_15295	COG2197	response regulator
E4188_15300	COG3850	Histidine kinase
E4188_15305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4188_15310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4188_15320	COG0243	molybdopterin cofactor binding
E4188_15325	COG0437	4 iron, 4 sulfur cluster binding
E4188_15330	COG0348	domain, Protein
E4188_15340	COG3005	denitrification pathway
E4188_15345	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4188_15350	COG0315	cyclic pyranopterin monophosphate synthase activity
E4188_15355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4188_15360	COG0314	molybdopterin synthase activity
E4188_15375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4188_15380	COG0596	Alpha beta hydrolase
E4188_15385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4188_15395	COG0302	gtp cyclohydrolase
E4188_15400	COG0840	transmembrane signaling receptor activity
E4188_15405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4188_15415	COG0583	DNA-binding transcription factor activity
E4188_15420	COG2353	YceI-like domain
E4188_15430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4188_15445	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4188_15460	COG1166	arginine decarboxylase activity
E4188_15515	COG5433	transposase activity
E4188_15530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4188_15535	COG1187	pseudouridine synthase activity
E4188_15540	COG2807	transmembrane transport
E4188_15580	COG2979	Protein of unknown function (DUF533)
E4188_15595	COG1595	DNA-templated transcription, initiation
E4188_15610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_15620	COG1294	oxidase, subunit
E4188_15630	COG2814	Major facilitator Superfamily
E4188_15635	COG0656	L-ascorbic acid biosynthetic process
E4188_15655	COG0583	DNA-binding transcription factor activity
E4188_15660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4188_15665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4188_15670	COG2271	Major facilitator Superfamily
E4188_15675	COG1349	DNA-binding transcription factor activity
E4188_15685	COG0584	glycerophosphoryl diester phosphodiesterase
E4188_15690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_15695	COG0287	Prephenate dehydrogenase
E4188_15695	COG1605	Chorismate mutase
E4188_15705	COG3085	chromosome segregation
E4188_15710	COG4574	serine-type endopeptidase inhibitor activity
E4188_15730	COG1770	oligopeptidase
E4188_15735	COG4206	TonB-dependent receptor
E4188_15740	COG3083	sulfuric ester hydrolase activity
E4188_15745	COG3082	Protein of unknown function (DUF1414)
E4188_15750	COG3081	Nucleoid-associated protein
E4188_15755	COG2182	Extracellular solute-binding protein
E4188_15760	COG1175	transmembrane transport
E4188_15765	COG3833	ABC-type maltose transport systems, permease component
E4188_15770	COG3842	ATPase activity
E4188_15800	COG4783	chaperone-mediated protein folding
E4188_15810	COG1393	Belongs to the ArsC family
E4188_15820	COG1228	amidohydrolase
E4188_15835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4188_15840	COG2431	L-lysine efflux transmembrane transporter activity
E4188_15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_15870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4188_15880	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_15900	COG2271	Major facilitator Superfamily
E4188_15940	COG2373	Large extracellular alpha-helical protein
E4188_15945	COG4953	penicillin-binding protein 1C
E4188_15965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_15965	COG0301	tRNA thio-modification
E4188_15985	COG1334	flagellar protein FlaG
E4188_16020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_16030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4188_16045	COG0346	lactoylglutathione lyase activity
E4188_16050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4188_16055	COG4660	Part of a membrane complex involved in electron transport
E4188_16060	COG4659	FMN binding
E4188_16065	COG4658	electron transport chain
E4188_16070	COG4656	Part of a membrane complex involved in electron transport
E4188_16075	COG2878	Part of a membrane complex involved in electron transport
E4188_16080	COG4657	Part of a membrane complex involved in electron transport
E4188_16105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4188_16110	COG1288	antiporter activity
E4188_16115	COG0436	Aminotransferase
E4188_16125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4188_16130	COG2027	D-alanyl-D-alanine carboxypeptidase
E4188_16135	COG1061	Type III restriction enzyme res subunit
E4188_16140	COG1566	PFAM secretion protein HlyD family protein
E4188_16150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4188_16150	COG3264	Mechanosensitive ion channel
E4188_16155	COG1966	Carbon starvation protein
E4188_16160	COG3279	Response regulator of the LytR AlgR family
E4188_16165	COG3275	phosphorelay sensor kinase activity
E4188_16175	COG1454	alcohol dehydrogenase
E4188_16175	COG1012	belongs to the aldehyde dehydrogenase family
E4188_16180	COG2095	MarC family integral membrane protein
E4188_16190	COG0601	transmembrane transport
E4188_16195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_16200	COG0444	Belongs to the ABC transporter superfamily
E4188_16210	COG0861	Integral membrane protein TerC family
E4188_16215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4188_16225	COG1301	dicarboxylic acid transport
E4188_16240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4188_16255	COG0537	adenosine 5'-monophosphoramidase activity
E4188_16290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_16295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_16305	COG2354	Protein conserved in bacteria
E4188_16320	COG3150	esterase
E4188_16325	COG1252	NADH dehydrogenase
E4188_16340	COG0393	Putative heavy-metal-binding
E4188_16345	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4188_16350	COG1368	sulfuric ester hydrolase activity
E4188_16360	COG0527	aspartate kinase activity
E4188_16370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4188_16370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4188_16375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_16390	COG2315	Protein conserved in bacteria
E4188_16400	COG0583	DNA-binding transcription factor activity
E4188_16405	COG1620	l-lactate permease
E4188_16410	COG0247	lactate metabolic process
E4188_16415	COG1139	Iron-sulfur cluster binding protein
E4188_16460	COG3039	Transposase
E4188_16480	COG1136	(ABC) transporter
E4188_16500	COG2814	Major facilitator Superfamily
E4188_16520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E4188_16520	COG0493	'glutamate synthase
E4188_16525	COG0672	)-iron permease
E4188_16560	COG2308	Evidence 4 Homologs of previously reported genes of
E4188_16580	COG0659	secondary active sulfate transmembrane transporter activity
E4188_16595	COG5433	transposase activity
E4188_16605	COG3039	Transposase
E4188_16620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_16625	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_16630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_16635	COG1902	pentaerythritol trinitrate reductase activity
E4188_16640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4188_16650	COG4974	Belongs to the 'phage' integrase family
E4188_16655	COG3039	Transposase
E4188_16665	COG3039	Transposase
E4188_16670	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4188_16675	COG0437	4 iron, 4 sulfur cluster binding
E4188_16680	COG5557	Pfam Polysulphide reductase, NrfD
E4188_16685	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4188_16690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4188_16695	COG1773	rubredoxin
E4188_16705	COG0601	transmembrane transport
E4188_16710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_16715	COG0444	Belongs to the ABC transporter superfamily
E4188_16720	COG1124	(ABC) transporter
E4188_16725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4188_16730	COG0375	protein maturation
E4188_16735	COG0309	Hydrogenase expression formation protein (HypE)
E4188_16745	COG0298	carbon dioxide binding
E4188_16750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4188_16760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4188_16765	COG0326	Molecular chaperone. Has ATPase activity
E4188_16770	COG0563	adenylate kinase activity
E4188_16775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4188_16785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_16790	COG0840	transmembrane signaling receptor activity
E4188_16805	COG3300	MHYT domain
E4188_16805	COG5001	Diguanylate cyclase
E4188_16810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4188_16830	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4188_16835	COG3433	isochorismatase activity
E4188_16835	COG1535	isochorismatase
E4188_16840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4188_16845	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_16855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4188_16860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_16870	COG1120	ATPase activity
E4188_16875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_16880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_16885	COG4771	TonB-dependent receptor
E4188_16910	COG0644	oxidoreductase
E4188_16910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4188_16930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4188_16935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4188_16940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_16945	COG0861	Integral membrane protein TerC family
E4188_16960	COG1022	Amp-dependent synthetase and ligase
E4188_16965	COG0295	cytidine deaminase activity
E4188_16970	COG1346	cytolysis
E4188_16975	COG1380	Effector of murein hydrolase LrgA
E4188_16980	COG3345	alpha-galactosidase
E4188_16990	COG2925	Exonuclease
E4188_16995	COG0582	viral genome integration into host DNA
E4188_17060	COG1846	Transcriptional regulator
E4188_17075	COG3646	Phage regulatory protein
E4188_17090	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4188_17135	COG4626	Terminase
E4188_17135	COG1802	Transcriptional regulator
E4188_17240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4188_17245	COG0392	lysyltransferase activity
E4188_17245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4188_17260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_17265	COG0436	Aminotransferase
E4188_17270	COG0583	DNA-binding transcription factor activity
E4188_17275	COG2160	L-arabinose isomerase activity
E4188_17285	COG1069	ribulokinase activity
E4188_17290	COG1879	ABC-type sugar transport system periplasmic component
E4188_17300	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_17310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4188_17315	COG0254	rRNA binding
E4188_17325	COG2731	YhcH YjgK YiaL family protein
E4188_17330	COG0800	Aldolase
E4188_17335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_17350	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_17370	COG1451	nucleotide metabolic process
E4188_17385	COG3069	C4-dicarboxylate transmembrane transporter activity
E4188_17395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4188_17395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_17400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_17425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4188_17430	COG1053	succinate dehydrogenase
E4188_17440	COG0567	Dehydrogenase, E1 component
E4188_17445	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4188_17450	COG0045	succinate-CoA ligase (ADP-forming) activity
E4188_17455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4188_17470	COG2983	Belongs to the UPF0260 family
E4188_17475	COG1882	Formate acetyltransferase
E4188_17480	COG2116	formate transmembrane transporter activity
E4188_17485	COG1944	ATP diphosphatase activity
E4188_17505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4188_17510	COG1278	Cold shock
E4188_17515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4188_17520	COG0542	response to heat
E4188_17525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4188_17530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4188_17535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4188_17540	COG3134	Outer membrane lipoprotein
E4188_17545	COG3706	GGDEF domain
E4188_17550	COG0492	ferredoxin-NADP+ reductase activity
E4188_17555	COG0686	Belongs to the AlaDH PNT family
E4188_17565	COG1674	ftsk spoiiie
E4188_17565	COG0531	amino acid
E4188_17570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4188_17575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4188_17580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4188_17585	COG1286	toxin biosynthetic process
E4188_17590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4188_17595	COG2723	6-phospho-beta-galactosidase activity
E4188_17600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_17600	COG1263	PTS System
E4188_17605	COG1609	Transcriptional regulator
E4188_17615	COG4172	Belongs to the ABC transporter superfamily
E4188_17625	COG4171	peptide transport system, permease
E4188_17630	COG4168	peptide transport system, permease
E4188_17640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4188_17645	COG1842	Phage shock protein A
E4188_17660	COG3106	COG3106 Predicted ATPase
E4188_17665	COG3768	UPF0283 membrane protein
E4188_17675	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4188_17690	COG2199	diguanylate cyclase activity
E4188_17695	COG2885	chlorophyll binding
E4188_17705	COG1570	exodeoxyribonuclease VII activity
E4188_17715	COG0366	Alpha amylase catalytic
E4188_17715	COG1874	Beta-galactosidase
E4188_17725	COG0516	GMP reductase activity
E4188_17725	COG0517	IMP dehydrogenase activity
E4188_17730	COG0519	Catalyzes the synthesis of GMP from XMP
E4188_17730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4188_17760	COG2062	phosphohistidine phosphatase, SixA
E4188_17770	COG0697	spore germination
E4188_17775	COG4166	transmembrane transport
E4188_17780	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4188_17785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4188_17795	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4188_17800	COG1136	(ABC) transporter
E4188_17805	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4188_17825	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4188_17830	COG0740	serine-type endopeptidase activity
E4188_17835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4188_17840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4188_17845	COG0776	regulation of translation
E4188_17850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4188_17855	COG0488	(ABC) transporter
E4188_17860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4188_17865	COG3162	membrane
E4188_17870	COG2176	DNA-directed DNA polymerase activity
E4188_17880	COG1024	Enoyl-CoA hydratase
E4188_17885	COG1115	amino acid carrier protein
E4188_17900	COG1584	GPR1 FUN34 yaaH family protein
E4188_17925	COG1024	Enoyl-CoA hydratase
E4188_17935	COG1960	acyl-CoA dehydrogenase activity
E4188_17945	COG1960	acyl-CoA dehydrogenase activity
E4188_17950	COG1024	Enoyl-CoA hydratase
E4188_17955	COG1024	Enoyl-CoA hydratase
E4188_17965	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_17975	COG0730	response to heat
E4188_17995	COG3039	Transposase
E4188_18010	COG3039	Transposase
E4188_18025	COG5433	transposase activity
E4188_18045	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_18050	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_18055	COG1129	ABC transporter
E4188_18060	COG1879	ABC-type sugar transport system periplasmic component
E4188_18065	COG0583	DNA-binding transcription factor activity
E4188_18080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4188_18085	COG0243	molybdopterin cofactor binding
E4188_18095	COG3706	GGDEF domain
E4188_18100	COG0583	DNA-binding transcription factor activity
E4188_18105	COG2723	6-phospho-beta-galactosidase activity
E4188_18110	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_18115	COG0583	DNA-binding transcription factor activity
E4188_18135	COG5433	transposase activity
E4188_18140	COG3706	GGDEF domain
E4188_18170	COG1742	UPF0060 membrane protein
E4188_18185	COG0513	Belongs to the DEAD box helicase family
E4188_18190	COG0386	Belongs to the glutathione peroxidase family
E4188_18200	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4188_18215	COG0730	response to heat
E4188_18220	COG0583	DNA-binding transcription factor activity
E4188_18235	COG3593	DNA synthesis involved in DNA repair
E4188_18285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_18290	COG1011	Hydrolase
E4188_18295	COG1473	amidohydrolase
E4188_18300	COG0205	6-phosphofructokinase activity
E4188_18310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4188_18315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4188_18325	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4188_18330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4188_18400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_18405	COG2824	Alkylphosphonate utilization operon protein PhnA
E4188_18435	COG0406	alpha-ribazole phosphatase activity
E4188_18445	COG2840	Smr protein MutS2
E4188_18450	COG2890	protein-(glutamine-N5) methyltransferase activity
E4188_18455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4188_18465	COG0513	Belongs to the DEAD box helicase family
E4188_18470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4188_18475	COG0814	amino acid
E4188_18480	COG1609	Transcriptional regulator
E4188_18485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_18485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_18490	COG1105	Belongs to the carbohydrate kinase PfkB family
E4188_18495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_18495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_18495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4188_18500	COG3313	Fe-S protein
E4188_18505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4188_18510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_18520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4188_18530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4188_18555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4188_18560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4188_18565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4188_18570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4188_18590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_18595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4188_18600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_18600	COG0072	phenylalanine-tRNA ligase activity
E4188_18605	COG0776	regulation of translation
E4188_18610	COG0784	Response regulator, receiver
E4188_18610	COG2205	protein histidine kinase activity
E4188_18635	COG5001	Diguanylate cyclase
E4188_18635	COG3300	MHYT domain
E4188_18640	COG1609	Transcriptional regulator
E4188_18645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_18650	COG1879	ABC-type sugar transport system periplasmic component
E4188_18655	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_18660	COG1129	ABC transporter
E4188_18665	COG1869	D-ribose catabolic process
E4188_18685	COG0037	tRNA processing
E4188_18690	COG0589	response to stress
E4188_18695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4188_18720	COG2010	Cytochrome c
E4188_18735	COG3278	Belongs to the heme-copper respiratory oxidase family
E4188_18745	COG1956	GAF domain-containing protein
E4188_18750	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4188_18760	COG0308	aminopeptidase N
E4188_18770	COG2902	Dehydrogenase
E4188_18775	COG0167	dihydroorotate dehydrogenase activity
E4188_18785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4188_18785	COG0116	Belongs to the methyltransferase superfamily
E4188_18795	COG0488	(ABC) transporter
E4188_18810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4188_18815	COG1067	ATP-dependent peptidase activity
E4188_18880	COG3141	response to X-ray
E4188_18890	COG2995	paraquat-inducible protein a
E4188_18895	COG3008	intermembrane lipid transfer
E4188_18900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_18900	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4188_18915	COG0084	hydrolase, TatD family'
E4188_18920	COG0470	DNA polymerase III
E4188_18925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4188_18930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4188_18935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4188_18945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_18950	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_18960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4188_18965	COG0416	fatty acid biosynthetic process
E4188_18970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4188_18975	COG1399	metal-binding, possibly nucleic acid-binding protein
E4188_18985	COG0424	maF-like protein
E4188_18990	COG0546	phosphoglycolate phosphatase activity
E4188_19000	COG1530	ribonuclease E activity
E4188_19005	COG0306	phosphate transporter
E4188_19010	COG0717	Belongs to the dCTP deaminase family
E4188_19015	COG0572	uridine kinase
E4188_19020	COG0489	protein tyrosine kinase activity
E4188_19025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_19025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_19035	COG1254	Belongs to the acylphosphatase family
E4188_19040	COG0840	transmembrane signaling receptor activity
E4188_19045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4188_19055	COG0709	Synthesizes selenophosphate from selenide and ATP
E4188_19060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4188_19065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4188_19070	COG3437	response regulator, receiver
E4188_19080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4188_19090	COG1643	Atp-dependent helicase
E4188_19095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4188_19095	COG0617	tRNA 3'-terminal CCA addition
E4188_19095	COG0517	IMP dehydrogenase activity
E4188_19100	COG2197	response regulator
E4188_19120	COG1335	isochorismatase
E4188_19125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4188_19135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4188_19140	COG2832	Protein of unknown function (DUF454)
E4188_19145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4188_19155	COG0697	spore germination
E4188_19165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4188_19170	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_19175	COG0596	Alpha beta hydrolase
E4188_19185	COG1214	PFAM Peptidase M22, glycoprotease
E4188_19190	COG1199	ATP-dependent helicase activity
E4188_19200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4188_19205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4188_19210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4188_19215	COG0131	Imidazoleglycerol-phosphate dehydratase
E4188_19215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4188_19220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4188_19225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4188_19230	COG3437	response regulator, receiver
E4188_19240	COG2205	protein histidine kinase activity
E4188_19240	COG2198	Histidine kinase
E4188_19240	COG0784	Response regulator, receiver
E4188_19245	COG0107	imidazoleglycerol-phosphate synthase activity
E4188_19250	COG0140	phosphoribosyl-ATP diphosphatase activity
E4188_19250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4188_19260	COG2378	regulation of single-species biofilm formation
E4188_19265	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_19270	COG3134	Outer membrane lipoprotein
E4188_19285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_19310	COG4681	YaeQ
E4188_19320	COG1024	Enoyl-CoA hydratase
E4188_19320	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4188_19325	COG0183	Belongs to the thiolase family
E4188_19330	COG0714	Associated with various cellular activities
E4188_19355	COG2304	oxidoreductase activity
E4188_19365	COG1595	DNA-templated transcription, initiation
E4188_19375	COG2067	long-chain fatty acid transport protein
E4188_19380	COG2067	long-chain fatty acid transport protein
E4188_19385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4188_19390	COG2067	long-chain fatty acid transport protein
E4188_19405	COG1301	dicarboxylic acid transport
E4188_19410	COG3123	guanosine phosphorylase activity
E4188_19415	COG1760	l-serine dehydratase
E4188_19425	COG1760	l-serine dehydratase
E4188_19430	COG2951	lytic endotransglycosylase activity
E4188_19435	COG3100	YcgL domain-containing protein
E4188_19440	COG0850	regulation of cytokinetic process
E4188_19445	COG2894	cell division
E4188_19450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4188_19455	COG3099	Belongs to the UPF0263 family
E4188_19460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4188_19495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4188_19500	COG0697	spore germination
E4188_19505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4188_19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_19520	COG0307	riboflavin synthase, alpha
E4188_19560	COG0417	DNA replication proofreading
E4188_19585	COG1560	Kdo2-lipid A biosynthetic process
E4188_19590	COG1560	Kdo2-lipid A biosynthetic process
E4188_19600	COG0583	DNA-binding transcription factor activity
E4188_19605	COG0673	inositol 2-dehydrogenase activity
E4188_19610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4188_19615	COG2329	Antibiotic biosynthesis monooxygenase
E4188_19620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4188_19650	COG2501	S4 domain
E4188_19665	COG1132	(ABC) transporter
E4188_19670	COG1132	(ABC) transporter
E4188_19680	COG3118	belongs to the thioredoxin family
E4188_19685	COG0471	metal ion transport
E4188_19695	COG0058	SHG alpha-glucan phosphorylase activity
E4188_19725	COG0814	amino acid
E4188_19730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4188_19735	COG0514	ATP-dependent DNA helicase (RecQ)
E4188_19740	COG2766	serine protein kinase
E4188_19745	COG2718	Belongs to the UPF0229 family
E4188_19750	COG2719	SpoVR family
E4188_19760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4188_19765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4188_19775	COG0586	Pfam SNARE associated Golgi protein
E4188_19785	COG0556	nucleotide-excision repair
E4188_19800	COG2985	domain, Protein
E4188_19800	COG0569	domain protein
E4188_19805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_19825	COG4565	transcriptional regulatory protein
E4188_19830	COG3290	protein histidine kinase activity
E4188_19835	COG1940	carbohydrate kinase activity
E4188_19835	COG1846	Transcriptional regulator
E4188_19845	COG3012	SEC-C Motif Domain Protein
E4188_19850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4188_19855	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4188_19860	COG0247	lactate metabolic process
E4188_19870	COG5433	transposase activity
E4188_19885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4188_19890	COG0437	4 iron, 4 sulfur cluster binding
E4188_19895	COG3301	Polysulphide reductase, NrfD
E4188_19900	COG1138	Cytochrome C-type biogenesis protein
E4188_19905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_19910	COG4235	cytochrome complex assembly
E4188_19910	COG3088	subunit of a heme lyase
E4188_19930	COG3046	protein related to deoxyribodipyrimidine photolyase
E4188_19935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_19950	COG0517	IMP dehydrogenase activity
E4188_19960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4188_19965	COG0583	DNA-binding transcription factor activity
E4188_19975	COG4774	siderophore transport
E4188_19980	COG3708	Transcriptional regulator
E4188_19980	COG2207	Transcriptional regulator
E4188_19990	COG0583	DNA-binding transcription factor activity
E4188_19995	COG2910	NAD(P)H-binding
E4188_20010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4188_20035	COG3039	Transposase
E4188_20145	COG3328	transposase activity
E4188_20160	COG3550	peptidyl-serine autophosphorylation
E4188_20175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4188_20200	COG1435	thymidine kinase activity
E4188_20205	COG1757	Na H antiporter
E4188_20210	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_20215	COG2096	Adenosyltransferase
E4188_20220	COG3530	Putative quorum-sensing-regulated virulence factor
E4188_20225	COG0602	queuosine metabolic process
E4188_20230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4188_20250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4188_20260	COG0776	regulation of translation
E4188_20265	COG0539	negative regulation of cytoplasmic translation
E4188_20270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4188_20275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4188_20285	COG2814	Major facilitator Superfamily
E4188_20305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4188_20310	COG5001	Diguanylate cyclase
E4188_20310	COG3300	MHYT domain
E4188_20320	COG0583	DNA-binding transcription factor activity
E4188_20325	COG3437	response regulator, receiver
E4188_20350	COG4989	oxidoreductase activity
E4188_20355	COG0724	RNA recognition motif
E4188_20375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4188_20395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_20400	COG1360	Flagellar Motor Protein
E4188_20405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_20410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_20415	COG0649	NAD binding
E4188_20415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_20430	COG1034	ATP synthesis coupled electron transport
E4188_20435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4188_20440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_20445	COG0839	Belongs to the complex I subunit 6 family
E4188_20450	COG0713	ATP synthesis coupled electron transport
E4188_20460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_20465	COG1007	ATP synthesis coupled electron transport
E4188_20470	COG0047	phosphoribosylformylglycinamidine synthase activity
E4188_20470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4188_20475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_20485	COG1160	GTP binding
E4188_20490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_20495	COG2976	Protein conserved in bacteria
E4188_20500	COG0124	histidyl-tRNA synthetase
E4188_20520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4188_20525	COG0105	UTP biosynthetic process
E4188_20530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_20540	COG0633	Ferredoxin
E4188_20545	COG0443	Heat shock 70 kDa protein
E4188_20550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4188_20560	COG0822	iron-sulfur transferase activity
E4188_20565	COG1104	cysteine desulfurase activity
E4188_20585	COG3154	lipid carrier protein
E4188_20590	COG0826	peptidase U32
E4188_20595	COG0826	peptidase U32
E4188_20610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_20615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_20620	COG1862	Preprotein translocase
E4188_20625	COG0343	queuine tRNA-ribosyltransferase activity
E4188_20630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4188_20635	COG0517	IMP dehydrogenase activity
E4188_20645	COG3634	alkyl hydroperoxide reductase activity
E4188_20675	COG3039	Transposase
E4188_20685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4188_20685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4188_20690	COG0509	glycine decarboxylation via glycine cleavage system
E4188_20695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4188_20700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_20705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_20715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_20750	COG2814	Major facilitator Superfamily
E4188_20755	COG1136	(ABC) transporter
E4188_20755	COG0577	efflux transmembrane transporter activity
E4188_20760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_20765	COG0601	transmembrane transport
E4188_20775	COG0625	glutathione transferase activity
E4188_20790	COG0483	inositol monophosphate 1-phosphatase activity
E4188_20805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_20810	COG2056	Na+-H+ antiporter family
E4188_20815	COG2814	Major facilitator Superfamily
E4188_20820	COG0583	DNA-binding transcription factor activity
E4188_20825	COG5001	Diguanylate cyclase
E4188_20835	COG0513	Belongs to the DEAD box helicase family
E4188_20840	COG2050	protein possibly involved in aromatic compounds catabolism
E4188_20850	COG0247	lactate metabolic process
E4188_20850	COG0277	FAD linked oxidase domain protein
E4188_20860	COG1253	flavin adenine dinucleotide binding
E4188_20865	COG1902	pentaerythritol trinitrate reductase activity
E4188_20870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4188_20875	COG0647	UMP catabolic process
E4188_20885	COG0367	asparagine synthase
E4188_20895	COG0625	glutathione transferase activity
E4188_20905	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4188_20920	COG0564	pseudouridine synthase activity
E4188_20925	COG3706	GGDEF domain
E4188_20935	COG0840	transmembrane signaling receptor activity
E4188_20940	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_20960	COG4447	cellulose binding
E4188_20985	COG2855	membrane
E4188_20995	COG2814	Major facilitator Superfamily
E4188_21000	COG3246	L-lysine catabolic process to acetate
E4188_21005	COG2175	clavaminate synthase activity
E4188_21015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4188_21040	COG0670	Belongs to the BI1 family
E4188_21045	COG1289	transmembrane transporter activity
E4188_21050	COG2920	part of a sulfur-relay system
E4188_21055	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4188_21060	COG0285	dihydrofolate synthase activity
E4188_21065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4188_21070	COG0101	tRNA pseudouridine synthase activity
E4188_21080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4188_21085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4188_21090	COG0671	phosphoesterase, PA-phosphatase related
E4188_21095	COG1464	Belongs to the NlpA lipoprotein family
E4188_21115	COG1119	ATPase activity
E4188_21120	COG0574	Belongs to the PEP-utilizing enzyme family
E4188_21120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4188_21125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4188_21135	COG1113	amino acid transport
E4188_21180	COG1242	4 iron, 4 sulfur cluster binding
E4188_21185	COG0067	glutamate synthase
E4188_21185	COG0069	glutamate synthase activity
E4188_21185	COG0070	glutamate synthase
E4188_21190	COG0493	'glutamate synthase
E4188_21200	COG1126	abc transporter atp-binding protein
E4188_21205	COG0765	amino acid transport
E4188_21210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_21225	COG4104	PAAR repeat-containing protein
E4188_21235	COG0513	Belongs to the DEAD box helicase family
E4188_21265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4188_21270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4188_21275	COG0505	Belongs to the CarA family
E4188_21280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4188_21290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4188_21295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4188_21300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4188_21305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4188_21310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_21315	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4188_21365	COG2119	membrane
E4188_21430	COG3039	Transposase
E4188_21440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4188_21450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_21455	COG2261	transglycosylase associated protein
E4188_21460	COG0625	glutathione transferase activity
E4188_21545	COG0322	excinuclease ABC activity
E4188_21550	COG2197	response regulator
E4188_21555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4188_21560	COG2835	tetraacyldisaccharide 4'-kinase activity
E4188_21565	COG1663	tetraacyldisaccharide 4'-kinase activity
E4188_21570	COG1132	(ABC) transporter
E4188_21575	COG0658	competence protein
E4188_21575	COG2333	competence protein COMEC
E4188_21590	COG0433	COG0433 Predicted ATPase
E4188_21595	COG1448	Aminotransferase
E4188_21625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_21630	COG1199	ATP-dependent helicase activity
E4188_21640	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4188_21645	COG0477	Major facilitator Superfamily
E4188_21650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4188_21655	COG1785	Belongs to the alkaline phosphatase family
E4188_21680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4188_21685	COG2197	response regulator
E4188_21695	COG2271	Major facilitator Superfamily
E4188_21705	COG0675	Transposase, IS605 OrfB family
E4188_21720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_21725	COG0765	amino acid transport
E4188_21730	COG1126	abc transporter atp-binding protein
E4188_21740	COG0531	amino acid
E4188_21755	COG1253	flavin adenine dinucleotide binding
E4188_21770	COG0581	inorganic phosphate transmembrane transporter activity
E4188_21775	COG0573	inorganic phosphate transmembrane transporter activity
E4188_21790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4188_21815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4188_21820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4188_21825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4188_21840	COG3852	Histidine kinase
E4188_21855	COG2716	regulation of RNA biosynthetic process
E4188_21860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4188_21885	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4188_21885	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4188_21890	COG1706	bacterial-type flagellum-dependent cell motility
E4188_21895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4188_21910	COG4786	Flagellar basal body rod
E4188_21925	COG1815	bacterial-type flagellum-dependent cell motility
E4188_21930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4188_21935	COG0835	chemotaxis
E4188_21935	COG0784	Response regulator, receiver
E4188_21940	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4188_21955	COG0622	Phosphoesterase
E4188_21960	COG4166	transmembrane transport
E4188_21970	COG1187	pseudouridine synthase activity
E4188_21980	COG0675	Transposase, IS605 OrfB family
E4188_22000	COG0697	spore germination
E4188_22030	COG1278	Cold shock
E4188_22070	COG3132	Protein of unknown function, DUF480
E4188_22085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_22110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4188_22140	COG0297	glycogen (starch) synthase activity
E4188_22145	COG0438	transferase activity, transferring glycosyl groups
E4188_22485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_22520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4188_22715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_22830	COG1988	membrane-bound metal-dependent
E4188_22905	COG0681	Belongs to the peptidase S26 family
E4188_22975	COG4676	Protein conserved in bacteria
E4188_23030	COG1192	Involved in chromosome partitioning
E4188_23045	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_23105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4188_23115	COG4804	nuclease activity
E4188_23120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_23130	COG2771	luxR family
E4188_23130	COG2200	EAL domain
E4188_23245	COG4372	Transposase
E4188_23250	COG3436	PFAM IS66 Orf2 family protein
E4188_23285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_23335	COG4372	Transposase
E4188_23350	COG3173	Aminoglycoside phosphotransferase
E4188_23395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_23400	COG4644	lycopene metabolic process
E4188_23420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_23520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_23525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_23940	COG4372	Transposase
E4188_23955	COG0592	DNA-directed DNA polymerase activity