locus-tag	class	description
E4184_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4184_00010	COG0592	DNA-directed DNA polymerase activity
E4184_00020	COG0187	DNA topoisomerase II activity
E4184_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4184_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
E4184_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
E4184_00045	COG3977	Valine--pyruvate aminotransferase
E4184_00060	COG2814	Major facilitator Superfamily
E4184_00065	COG0745	RESPONSE REGULATOR receiver
E4184_00070	COG2205	protein histidine kinase activity
E4184_00125	COG1484	DNA-dependent DNA replication
E4184_00130	COG4584	PFAM Integrase catalytic
E4184_00155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4184_00160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_00160	COG4191	Histidine kinase
E4184_00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_00175	COG1309	transcriptional regulator
E4184_00210	COG0561	phosphatase activity
E4184_00215	COG2267	carboxylic ester hydrolase activity
E4184_00225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4184_00235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4184_00240	COG1758	RNA polymerase activity
E4184_00255	COG0859	PFAM glycosyl transferase family 9
E4184_00260	COG3642	lipopolysaccharide core region biosynthetic process
E4184_00300	COG0589	response to stress
E4184_00305	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4184_00310	COG3706	GGDEF domain
E4184_00315	COG1528	Iron-storage protein
E4184_00320	COG2081	HI0933 family
E4184_00325	COG2223	nitrite transmembrane transporter activity
E4184_00335	COG3275	phosphorelay sensor kinase activity
E4184_00340	COG3279	Response regulator of the LytR AlgR family
E4184_00345	COG2223	nitrite transmembrane transporter activity
E4184_00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4184_00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4184_00360	COG4206	TonB-dependent receptor
E4184_00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4184_00400	COG1042	CoA-binding domain protein
E4184_00400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4184_00400	COG0045	succinate-CoA ligase (ADP-forming) activity
E4184_00410	COG0583	DNA-binding transcription factor activity
E4184_00415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4184_00420	COG0166	Belongs to the GPI family
E4184_00425	COG0668	transmembrane transport
E4184_00440	COG1309	transcriptional regulator
E4184_00450	COG0756	dUTP diphosphatase activity
E4184_00470	COG3385	transposase activity
E4184_00525	COG3385	transposase activity
E4184_00530	COG1538	Outer membrane efflux protein
E4184_00555	COG1484	DNA-dependent DNA replication
E4184_00560	COG4584	PFAM Integrase catalytic
E4184_00600	COG0745	RESPONSE REGULATOR receiver
E4184_00605	COG5002	protein histidine kinase activity
E4184_00610	COG5433	transposase activity
E4184_00625	COG4584	PFAM Integrase catalytic
E4184_00630	COG1484	DNA-dependent DNA replication
E4184_00660	COG2132	Multicopper oxidase
E4184_00675	COG3039	Transposase
E4184_00685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4184_00690	COG2003	Belongs to the UPF0758 family
E4184_00695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4184_00700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4184_00710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4184_00715	COG2990	Protein conserved in bacteria
E4184_00720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4184_00725	COG0859	PFAM glycosyl transferase family 9
E4184_00730	COG0463	Glycosyl transferase, family 2
E4184_00735	COG0859	PFAM glycosyl transferase family 9
E4184_00740	COG1519	Transferase
E4184_00750	COG3550	peptidyl-serine autophosphorylation
E4184_00770	COG5433	transposase activity
E4184_00790	COG1857	crispr-associated protein
E4184_00805	COG1518	maintenance of DNA repeat elements
E4184_00810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4184_00855	COG1561	YicC-like family, N-terminal region
E4184_00860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4184_00865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4184_00875	COG0789	Transcriptional regulator
E4184_00880	COG2203	Gaf domain
E4184_00880	COG4251	negative regulation of phosphorylation
E4184_00880	COG5001	Diguanylate cyclase
E4184_00880	COG3706	GGDEF domain
E4184_00885	COG3084	Protein conserved in bacteria
E4184_00895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4184_00900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4184_00910	COG1335	isochorismatase
E4184_00920	COG1683	Conserved Protein
E4184_00925	COG0204	Acyl-transferase
E4184_00930	COG0204	Acyl-transferase
E4184_00935	COG0606	chelatase, subunit chli
E4184_00950	COG3978	acetolactate synthase activity
E4184_00960	COG0129	dihydroxy-acid dehydratase activity
E4184_00975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4184_00980	COG0254	rRNA binding
E4184_00985	COG0702	epimerase
E4184_00990	COG0281	malic enzyme
E4184_01000	COG2205	protein histidine kinase activity
E4184_01005	COG0745	RESPONSE REGULATOR receiver
E4184_01010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4184_01025	COG0366	Alpha amylase catalytic
E4184_01040	COG0443	Heat shock 70 kDa protein
E4184_01045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4184_01050	COG3045	CreA protein
E4184_01070	COG0174	glutamine synthetase
E4184_01090	COG3842	ATPase activity
E4184_01095	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4184_01100	COG1177	transmembrane transport
E4184_01105	COG2258	MOSC domain
E4184_01120	COG2050	protein possibly involved in aromatic compounds catabolism
E4184_01125	COG0514	ATP-dependent DNA helicase (RecQ)
E4184_01135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4184_01145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4184_01150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4184_01155	COG2239	Acts as a magnesium transporter
E4184_01160	COG1648	precorrin-2 dehydrogenase activity
E4184_01160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4184_01165	COG2116	formate transmembrane transporter activity
E4184_01175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4184_01180	COG0842	Transport permease protein
E4184_01185	COG0842	Transport permease protein
E4184_01190	COG1131	(ABC) transporter
E4184_01195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_01210	COG0477	Major facilitator Superfamily
E4184_01215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4184_01220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4184_01240	COG1595	DNA-templated transcription, initiation
E4184_01245	COG3806	Anti-sigma factor
E4184_01250	COG1968	undecaprenyl-diphosphatase activity
E4184_01255	COG0667	Aldo Keto reductase
E4184_01260	COG2017	converts alpha-aldose to the beta-anomer
E4184_01265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4184_01275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4184_01280	COG1609	Transcriptional regulator
E4184_01285	COG3250	beta-galactosidase activity
E4184_01300	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4184_01325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4184_01330	COG1288	antiporter activity
E4184_01335	COG1438	arginine binding
E4184_01340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4184_01345	COG0540	Belongs to the ATCase OTCase family
E4184_01370	COG3040	lipid binding
E4184_01375	COG2207	Transcriptional regulator
E4184_01380	COG1979	alcohol dehydrogenase
E4184_01385	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4184_01390	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4184_01395	COG3681	Belongs to the UPF0597 family
E4184_01405	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4184_01410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4184_01415	COG0564	pseudouridine synthase activity
E4184_01425	COG0542	response to heat
E4184_01435	COG2863	cytochrome
E4184_01440	COG3258	Cytochrome c
E4184_01445	COG2502	aspartate--ammonia ligase
E4184_01450	COG1522	sequence-specific DNA binding
E4184_01460	COG5413	integral membrane protein
E4184_01465	COG0517	IMP dehydrogenase activity
E4184_01465	COG0516	GMP reductase activity
E4184_01470	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_01485	COG2205	protein histidine kinase activity
E4184_01495	COG2204	response regulator
E4184_01510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4184_01515	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4184_01530	COG0745	RESPONSE REGULATOR receiver
E4184_01535	COG2205	protein histidine kinase activity
E4184_01545	COG0243	molybdopterin cofactor binding
E4184_01550	COG3005	denitrification pathway
E4184_01555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4184_01560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4184_01565	COG0569	domain protein
E4184_01570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4184_01595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4184_01610	COG0250	Participates in transcription elongation, termination and antitermination
E4184_01615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4184_01620	COG0081	regulation of translation
E4184_01625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4184_01630	COG0222	ribosome binding
E4184_01635	COG0085	RNA polymerase activity
E4184_01640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4184_01645	COG2964	Protein conserved in bacteria
E4184_01665	COG2168	tRNA wobble position uridine thiolation
E4184_01670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4184_01675	COG0049	tRNA binding
E4184_01680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4184_01685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4184_01690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4184_01730	COG1538	Outer membrane efflux protein
E4184_01740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_01765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4184_01780	COG0789	Transcriptional regulator
E4184_01785	COG3039	Transposase
E4184_01790	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4184_01795	COG2252	PERMEase
E4184_01800	COG2376	Dihydroxyacetone kinase
E4184_01805	COG1461	Dihydroxyacetone kinase
E4184_01810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4184_01810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4184_01810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_01815	COG3284	Transcriptional regulator
E4184_01820	COG0583	DNA-binding transcription factor activity
E4184_01825	COG2957	Belongs to the agmatine deiminase family
E4184_01835	COG2957	Belongs to the agmatine deiminase family
E4184_01845	COG0628	permease
E4184_01850	COG0671	phosphoesterase, PA-phosphatase related
E4184_01870	COG0753	catalase activity
E4184_01875	COG1247	-acetyltransferase
E4184_01880	COG2207	Transcriptional regulator
E4184_01900	COG2199	diguanylate cyclase activity
E4184_01910	COG3842	ATPase activity
E4184_01920	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4184_01945	COG0583	DNA-binding transcription factor activity
E4184_01955	COG1741	Belongs to the pirin family
E4184_01960	COG2259	Doxx family
E4184_01965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4184_01970	COG1074	ATP-dependent DNA helicase activity
E4184_01975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4184_01985	COG3385	transposase activity
E4184_01990	COG0346	lactoylglutathione lyase activity
E4184_02000	COG0004	ammonium transporteR
E4184_02005	COG0347	Belongs to the P(II) protein family
E4184_02010	COG3706	GGDEF domain
E4184_02025	COG2197	response regulator
E4184_02050	COG1278	Cold shock
E4184_02055	COG4771	TonB-dependent receptor
E4184_02060	COG2205	protein histidine kinase activity
E4184_02065	COG0745	RESPONSE REGULATOR receiver
E4184_02085	COG3071	HemY protein
E4184_02090	COG2959	enzyme of heme biosynthesis
E4184_02100	COG0181	hydroxymethylbilane synthase activity
E4184_02105	COG3072	Adenylate cyclase
E4184_02110	COG0400	carboxylic ester hydrolase activity
E4184_02115	COG1965	Belongs to the frataxin family
E4184_02125	COG0019	diaminopimelate decarboxylase activity
E4184_02130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4184_02145	COG1011	Hydrolase
E4184_02165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4184_02170	COG0561	phosphatase activity
E4184_02180	COG1988	membrane-bound metal-dependent
E4184_02185	COG1058	Belongs to the CinA family
E4184_02185	COG1546	Belongs to the CinA family
E4184_02195	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4184_02205	COG1522	sequence-specific DNA binding
E4184_02210	COG1368	sulfuric ester hydrolase activity
E4184_02225	COG1285	pathogenesis
E4184_02245	COG4221	oxidoreductase activity
E4184_02260	COG1979	alcohol dehydrogenase
E4184_02270	COG2873	o-acetylhomoserine
E4184_02295	COG5380	lipid catabolic process
E4184_02300	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4184_02315	COG2949	membrane
E4184_02320	COG0318	PFAM AMP-dependent synthetase and ligase
E4184_02325	COG1441	menaquinone biosynthetic process
E4184_02330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4184_02335	COG0596	Alpha beta hydrolase
E4184_02340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4184_02345	COG1169	isochorismate synthase
E4184_02350	COG1575	Belongs to the MenA family. Type 1 subfamily
E4184_02355	COG1966	Carbon starvation protein
E4184_02360	COG2879	small protein
E4184_02365	COG0523	cobalamin synthesis protein
E4184_02390	COG0513	Belongs to the DEAD box helicase family
E4184_02400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4184_02405	COG4932	domain protein
E4184_02405	COG5492	domain, Protein
E4184_02410	COG1671	Belongs to the UPF0178 family
E4184_02435	COG3722	fumarate hydratase activity
E4184_02440	COG0246	Mannitol dehydrogenase
E4184_02445	COG2213	PTS system mannitol-specific
E4184_02445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_02450	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4184_02465	COG2771	luxR family
E4184_02480	COG1560	Kdo2-lipid A biosynthetic process
E4184_02485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4184_02485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4184_02490	COG1538	Outer membrane efflux protein
E4184_02495	COG0494	nUDIX hydrolase
E4184_02500	COG3151	Protein conserved in bacteria
E4184_02510	COG3150	esterase
E4184_02515	COG1051	belongs to the nudix hydrolase family
E4184_02530	COG1566	PFAM secretion protein HlyD family protein
E4184_02535	COG1289	transmembrane transporter activity
E4184_02565	COG0456	acetyltransferase
E4184_02610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4184_02630	COG0204	Acyl-transferase
E4184_02635	COG1842	Phage shock protein A
E4184_02650	COG2827	Endonuclease containing a URI domain
E4184_02655	COG2962	Rard protein
E4184_02660	COG1573	uracil-dna glycosylase
E4184_02670	COG0583	DNA-binding transcription factor activity
E4184_02675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4184_02680	COG1121	(ABC) transporter
E4184_02685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4184_02705	COG0739	heme binding
E4184_02715	COG3068	Protein conserved in bacteria
E4184_02735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4184_02745	COG1546	Belongs to the CinA family
E4184_02750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4184_02760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4184_02765	COG0527	aspartate kinase activity
E4184_02770	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4184_02805	COG1686	Belongs to the peptidase S11 family
E4184_02810	COG0586	Pfam SNARE associated Golgi protein
E4184_02815	COG1253	flavin adenine dinucleotide binding
E4184_02825	COG2927	DNA polymerase III (CHI subunit)
E4184_02830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4184_02835	COG0795	lipopolysaccharide-transporting ATPase activity
E4184_02840	COG0795	lipopolysaccharide-transporting ATPase activity
E4184_02855	COG0582	viral genome integration into host DNA
E4184_02870	COG4584	PFAM Integrase catalytic
E4184_02875	COG1484	DNA-dependent DNA replication
E4184_02895	COG1160	GTP binding
E4184_02945	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4184_02960	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4184_02975	COG0004	ammonium transporteR
E4184_02980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4184_03000	COG0084	hydrolase, TatD family'
E4184_03005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4184_03015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4184_03020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4184_03025	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4184_03040	COG3064	Membrane
E4184_03050	COG0560	Phosphoserine phosphatase
E4184_03065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4184_03075	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4184_03080	COG0776	regulation of translation
E4184_03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4184_03100	COG0735	belongs to the Fur family
E4184_03120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4184_03125	COG0513	Belongs to the DEAD box helicase family
E4184_03130	COG3022	response to hydroperoxide
E4184_03145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4184_03150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4184_03155	COG0762	integral membrane protein
E4184_03160	COG1872	DUF167
E4184_03180	COG3112	Uncharacterised protein family (UPF0231)
E4184_03190	COG3835	regulator
E4184_03195	COG2610	gluconate transmembrane transporter activity
E4184_03200	COG1929	Belongs to the glycerate kinase type-1 family
E4184_03215	COG0583	DNA-binding transcription factor activity
E4184_03220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4184_03235	COG0347	Belongs to the P(II) protein family
E4184_03260	COG2837	iron assimilation
E4184_03265	COG1438	arginine binding
E4184_03270	COG1126	abc transporter atp-binding protein
E4184_03275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_03280	COG4215	(ABC) transporter
E4184_03285	COG4160	amino acid transport
E4184_03290	COG0039	L-malate dehydrogenase activity
E4184_03295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4184_03300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4184_03300	COG1017	nitric oxide dioxygenase activity
E4184_03310	COG4536	flavin adenine dinucleotide binding
E4184_03315	COG4137	Cytochrome C assembly protein
E4184_03320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4184_03325	COG0228	four-way junction DNA binding
E4184_03330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4184_03335	COG0336	Belongs to the RNA methyltransferase TrmD family
E4184_03340	COG0335	large ribosomal subunit rRNA binding
E4184_03355	COG1051	belongs to the nudix hydrolase family
E4184_03365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4184_03370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4184_03375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4184_03385	COG0583	DNA-binding transcription factor activity
E4184_03390	COG0640	Transcriptional regulator
E4184_03395	COG0268	Binds directly to 16S ribosomal RNA
E4184_03400	COG0728	peptidoglycan biosynthetic process
E4184_03405	COG0196	riboflavin kinase activity
E4184_03410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4184_03415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4184_03420	COG1047	Peptidyl-prolyl cis-trans
E4184_03425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4184_03430	COG4968	Prepilin-type N-terminal cleavage methylation domain
E4184_03455	COG5433	transposase activity
E4184_03475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4184_03475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4184_03490	COG1854	S-ribosylhomocysteine lyase activity
E4184_03495	COG3706	GGDEF domain
E4184_03500	COG0557	exoribonuclease II activity
E4184_03505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4184_03515	COG2153	protein acetylation
E4184_03530	COG1914	H( )-stimulated, divalent metal cation uptake system
E4184_03535	COG0360	Binds together with S18 to 16S ribosomal RNA
E4184_03540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4184_03545	COG0359	binds to the 23S rRNA
E4184_03585	COG1238	metal cluster binding
E4184_03590	COG0612	Peptidase, M16
E4184_03595	COG2918	glutathione biosynthetic process
E4184_03600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4184_03605	COG1027	Aspartate ammonia-lyase
E4184_03610	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4184_03615	COG0534	Mate efflux family protein
E4184_03620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4184_03625	COG0459	protein refolding
E4184_03645	COG0564	pseudouridine synthase activity
E4184_03650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4184_03680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4184_03690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4184_03695	COG4208	sulfate ABC transporter
E4184_03700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4184_03705	COG0583	DNA-binding transcription factor activity
E4184_03710	COG3397	chitin binding
E4184_03715	COG0840	transmembrane signaling receptor activity
E4184_03740	COG1328	CTP reductase activity
E4184_03745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4184_03760	COG1448	Aminotransferase
E4184_03765	COG2194	sulfuric ester hydrolase activity
E4184_03775	COG1192	Involved in chromosome partitioning
E4184_03785	COG1215	transferase activity, transferring glycosyl groups
E4184_03795	COG0457	Tetratricopeptide repeat
E4184_03795	COG3118	belongs to the thioredoxin family
E4184_03830	COG0513	Belongs to the DEAD box helicase family
E4184_03840	COG0840	transmembrane signaling receptor activity
E4184_03850	COG4166	transmembrane transport
E4184_03860	COG0110	maltose O-acetyltransferase activity
E4184_03870	COG1024	Enoyl-CoA hydratase
E4184_03885	COG4221	oxidoreductase activity
E4184_03890	COG0442	prolyl-tRNA aminoacylation
E4184_03895	COG0840	transmembrane signaling receptor activity
E4184_03900	COG0632	four-way junction helicase activity
E4184_03905	COG2255	four-way junction helicase activity
E4184_03910	COG1271	oxidase subunit
E4184_03915	COG1294	oxidase, subunit
E4184_03920	COG4890	Cyd operon protein YbgT
E4184_03925	COG3790	cyd operon protein YbgE
E4184_03930	COG0824	Thioesterase
E4184_03935	COG0811	peptide transport
E4184_03950	COG0823	Involved in the tonB-independent uptake of proteins
E4184_03955	COG2885	chlorophyll binding
E4184_03960	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4184_04035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4184_04045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4184_04050	COG1640	4-alpha-glucanotransferase
E4184_04055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4184_04080	COG2130	NADP-dependent
E4184_04085	COG1846	Transcriptional regulator
E4184_04115	COG0561	phosphatase activity
E4184_04130	COG0733	neurotransmitter:sodium symporter activity
E4184_04135	COG0733	neurotransmitter:sodium symporter activity
E4184_04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4184_04160	COG1794	racemase activity, acting on amino acids and derivatives
E4184_04170	COG1022	Amp-dependent synthetase and ligase
E4184_04180	COG0456	acetyltransferase
E4184_04195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4184_04200	COG5001	Diguanylate cyclase
E4184_04200	COG3300	MHYT domain
E4184_04210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4184_04220	COG1902	pentaerythritol trinitrate reductase activity
E4184_04240	COG2957	Belongs to the agmatine deiminase family
E4184_04245	COG0154	amidase activity
E4184_04285	COG0513	Belongs to the DEAD box helicase family
E4184_04290	COG3706	GGDEF domain
E4184_04325	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4184_04415	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4184_04420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4184_04430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_04460	COG0745	RESPONSE REGULATOR receiver
E4184_04465	COG3104	oligopeptide transport
E4184_04470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4184_04475	COG1555	photosystem II stabilization
E4184_04485	COG2350	Protein conserved in bacteria
E4184_04490	COG2917	probably involved in intracellular septation
E4184_04500	COG1272	protein, Hemolysin III
E4184_04505	COG2985	domain, Protein
E4184_04505	COG0569	domain protein
E4184_04515	COG0477	Major facilitator Superfamily
E4184_04520	COG0583	DNA-binding transcription factor activity
E4184_04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4184_04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4184_04545	COG2731	YhcH YjgK YiaL family protein
E4184_04555	COG0668	transmembrane transport
E4184_04560	COG1376	ErfK ybiS ycfS ynhG family protein
E4184_04565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4184_04580	COG0789	Transcriptional regulator
E4184_04605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4184_04615	COG0488	(ABC) transporter
E4184_04620	COG0516	GMP reductase activity
E4184_04620	COG0517	IMP dehydrogenase activity
E4184_04625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4184_04630	COG0784	Response regulator, receiver
E4184_04630	COG0835	chemotaxis
E4184_04635	COG2755	lipolytic protein G-D-S-L family
E4184_04640	COG4181	ATPase activity
E4184_04645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4184_04650	COG1090	epimerase
E4184_04655	COG2200	EAL domain
E4184_04660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4184_04665	COG2234	aminopeptidase activity
E4184_04665	COG4935	Belongs to the peptidase S8 family
E4184_04670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4184_04675	COG3171	Protein conserved in bacteria
E4184_04680	COG2066	Belongs to the glutaminase family
E4184_04685	COG2897	thiosulfate sulfurtransferase activity
E4184_04725	COG3385	transposase activity
E4184_04740	COG0582	viral genome integration into host DNA
E4184_04760	COG5001	Diguanylate cyclase
E4184_04760	COG5002	protein histidine kinase activity
E4184_04760	COG3447	MASE1 domain protein
E4184_04765	COG4974	Belongs to the 'phage' integrase family
E4184_04770	COG5433	transposase activity
E4184_04800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4184_04800	COG0784	Response regulator, receiver
E4184_04825	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4184_04830	COG3300	MHYT domain
E4184_04830	COG5001	Diguanylate cyclase
E4184_04855	COG4628	conserved protein (DUF2132)
E4184_04860	COG0688	phosphatidylethanolamine metabolic process
E4184_04870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4184_04910	COG1278	Cold shock
E4184_04925	COG0840	transmembrane signaling receptor activity
E4184_04930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4184_04935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4184_04985	COG0848	biopolymer transport protein
E4184_04990	COG0811	peptide transport
E4184_04995	COG0811	peptide transport
E4184_05005	COG4206	TonB-dependent receptor
E4184_05010	COG4174	ABC transporter (Permease)
E4184_05015	COG4239	(ABC) transporter, permease
E4184_05020	COG0747	negative chemotaxis
E4184_05025	COG0444	Belongs to the ABC transporter superfamily
E4184_05030	COG4608	Belongs to the ABC transporter superfamily
E4184_05040	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4184_05055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4184_05075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4184_05115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4184_05115	COG1116	anion transmembrane transporter activity
E4184_05120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4184_05125	COG1116	anion transmembrane transporter activity
E4184_05130	COG2146	nitrite reductase [NAD(P)H] activity
E4184_05130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4184_05135	COG2146	nitrite reductase [NAD(P)H] activity
E4184_05135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4184_05140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4184_05145	COG2313	pseudouridylate synthase activity
E4184_05165	COG5433	transposase activity
E4184_05170	COG1858	cytochrome C peroxidase
E4184_05185	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4184_05195	COG2966	Psort location CytoplasmicMembrane, score
E4184_05200	COG3610	response to peptide
E4184_05210	COG4175	Glycine betaine
E4184_05215	COG4176	ABC-type proline glycine betaine transport system permease component
E4184_05220	COG2113	Glycine betaine
E4184_05230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4184_05240	COG0384	phenazine biosynthesis protein PhzF
E4184_05245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4184_05260	COG0786	glutamate:sodium symporter activity
E4184_05265	COG0252	asparaginase activity
E4184_05270	COG3139	Protein of unknown function (DUF1315)
E4184_05295	COG0616	signal peptide processing
E4184_05300	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4184_05300	COG1902	pentaerythritol trinitrate reductase activity
E4184_05305	COG0778	Nitroreductase
E4184_05315	COG2264	protein methyltransferase activity
E4184_05320	COG0604	alcohol dehydrogenase
E4184_05325	COG0583	DNA-binding transcription factor activity
E4184_05330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_05330	COG1263	PTS System
E4184_05330	COG2190	(PTS) system
E4184_05335	COG4145	pantothenate transmembrane transporter activity
E4184_05340	COG3924	membrane
E4184_05345	COG0439	Biotin carboxylase
E4184_05350	COG0511	ligase activity, forming carbon-carbon bonds
E4184_05355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4184_05360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4184_05375	COG3381	protein complex oligomerization
E4184_05385	COG3005	denitrification pathway
E4184_05390	COG0745	RESPONSE REGULATOR receiver
E4184_05400	COG0784	Response regulator, receiver
E4184_05400	COG2198	Histidine kinase
E4184_05400	COG2205	protein histidine kinase activity
E4184_05410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4184_05415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4184_05420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4184_05420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4184_05435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4184_05440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4184_05445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4184_05450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4184_05455	COG4172	Belongs to the ABC transporter superfamily
E4184_05475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4184_05480	COG0142	geranyltranstransferase activity
E4184_05485	COG1722	exodeoxyribonuclease VII activity
E4184_05490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4184_05495	COG1360	Flagellar Motor Protein
E4184_05500	COG2823	Periplasmic or secreted lipoprotein
E4184_05510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4184_05525	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
E4184_05540	COG1534	Rna-binding protein
E4184_05545	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4184_05555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4184_05560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4184_05565	COG0149	triose-phosphate isomerase activity
E4184_05570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4184_05585	COG0779	Required for maturation of 30S ribosomal subunits
E4184_05590	COG0195	Participates in both transcription termination and antitermination
E4184_05595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4184_05600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4184_05605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4184_05610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4184_05615	COG1185	polyribonucleotide nucleotidyltransferase activity
E4184_05620	COG2211	Major facilitator Superfamily
E4184_05625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4184_05635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4184_05655	COG0312	modulator of DNA gyrase
E4184_05665	COG3385	transposase activity
E4184_05680	COG4974	Belongs to the 'phage' integrase family
E4184_05685	COG1970	mechanosensitive ion channel activity
E4184_05700	COG0789	Transcriptional regulator
E4184_05715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4184_05725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4184_05735	COG0321	lipoyl(octanoyl) transferase activity
E4184_05740	COG2921	Belongs to the UPF0250 family
E4184_05745	COG1686	Belongs to the peptidase S11 family
E4184_05750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4184_05755	COG2951	lytic endotransglycosylase activity
E4184_05765	COG0772	Belongs to the SEDS family
E4184_05770	COG0768	penicillin binding
E4184_05775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4184_05780	COG0799	negative regulation of ribosome biogenesis
E4184_05785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4184_05800	COG0495	leucyl-tRNA aminoacylation
E4184_05805	COG2888	peptidyl-tyrosine sulfation
E4184_05810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4184_05815	COG4535	Mg2 and Co2 transporter CorC
E4184_05825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4184_05830	COG1702	phosphate starvation-inducible protein PhoH
E4184_05835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4184_05840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4184_05855	COG0583	DNA-binding transcription factor activity
E4184_05865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_05875	COG3706	GGDEF domain
E4184_05885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4184_05895	COG3647	Membrane
E4184_05900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4184_05915	COG0516	GMP reductase activity
E4184_05925	COG0642	Histidine kinase
E4184_05930	COG0745	RESPONSE REGULATOR receiver
E4184_05940	COG0300	oxidoreductase activity
E4184_05950	COG1022	Amp-dependent synthetase and ligase
E4184_05960	COG4106	trans-aconitate 2-methyltransferase activity
E4184_05965	COG3214	Protein conserved in bacteria
E4184_05970	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4184_05975	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4184_05980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4184_05985	COG1053	succinate dehydrogenase
E4184_05995	COG0584	glycerophosphoryl diester phosphodiesterase
E4184_06000	COG1511	domain protein
E4184_06000	COG3264	Mechanosensitive ion channel
E4184_06005	COG0534	Mate efflux family protein
E4184_06010	COG0739	heme binding
E4184_06020	COG3121	Chaperone
E4184_06025	COG3188	usher protein
E4184_06045	COG0583	DNA-binding transcription factor activity
E4184_06060	COG0583	DNA-binding transcription factor activity
E4184_06065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4184_06095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4184_06100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4184_06110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4184_06115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4184_06120	COG0546	phosphoglycolate phosphatase activity
E4184_06125	COG0180	Tryptophanyl-tRNA synthetase
E4184_06140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4184_06150	COG1012	belongs to the aldehyde dehydrogenase family
E4184_06160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_06175	COG0488	(ABC) transporter
E4184_06185	COG0366	Alpha amylase catalytic
E4184_06205	COG0490	domain, Protein
E4184_06205	COG0471	metal ion transport
E4184_06250	COG0012	GTP binding
E4184_06260	COG0193	aminoacyl-tRNA hydrolase activity
E4184_06265	COG0737	Belongs to the 5'-nucleotidase family
E4184_06270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4184_06280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4184_06285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4184_06290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4184_06295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4184_06300	COG2890	protein-(glutamine-N5) methyltransferase activity
E4184_06310	COG2912	Transglutaminase-like superfamily
E4184_06330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4184_06345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4184_06350	COG1115	amino acid carrier protein
E4184_06370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4184_06380	COG0189	ligase activity
E4184_06385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4184_06395	COG3091	SprT-like family
E4184_06405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4184_06435	COG0456	acetyltransferase
E4184_06445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4184_06450	COG0739	heme binding
E4184_06455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4184_06460	COG3408	Glycogen debranching enzyme
E4184_06460	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4184_06470	COG1881	PFAM PEBP family protein
E4184_06480	COG0583	DNA-binding transcription factor activity
E4184_06490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4184_06500	COG0583	DNA-binding transcription factor activity
E4184_06505	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_06510	COG0616	signal peptide processing
E4184_06515	COG3724	N-succinylarginine dihydrolase activity
E4184_06530	COG0840	transmembrane signaling receptor activity
E4184_06540	COG2971	BadF BadG BcrA BcrD
E4184_06550	COG4608	Belongs to the ABC transporter superfamily
E4184_06555	COG0444	Belongs to the ABC transporter superfamily
E4184_06560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4184_06580	COG1073	alpha beta
E4184_06580	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E4184_06580	COG3064	Membrane
E4184_06590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4184_06610	COG1677	Flagellar hook-basal body complex protein FliE
E4184_06620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4184_06675	COG1684	flagellar biosynthetic protein fliR
E4184_06685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4184_06710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4184_06715	COG2198	Histidine kinase
E4184_06715	COG0643	Histidine kinase
E4184_06715	COG0784	Response regulator, receiver
E4184_06720	COG2201	protein-glutamate methylesterase activity
E4184_06725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4184_06730	COG1360	Flagellar Motor Protein
E4184_06735	COG1192	Involved in chromosome partitioning
E4184_06745	COG0835	chemotaxis
E4184_06760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4184_06765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4184_06770	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4184_06775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4184_06780	COG1138	Cytochrome C-type biogenesis protein
E4184_06785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4184_06790	COG4235	cytochrome complex assembly
E4184_06790	COG3088	subunit of a heme lyase
E4184_06810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4184_06815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4184_06815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4184_06830	COG0259	pyridoxamine-phosphate oxidase activity
E4184_06860	COG3153	acetyltransferase
E4184_06885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4184_06910	COG2801	Transposase and inactivated derivatives
E4184_06920	COG0582	viral genome integration into host DNA
E4184_06930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4184_06935	COG2867	negative regulation of translational initiation
E4184_06945	COG0702	epimerase
E4184_06950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4184_06955	COG1454	alcohol dehydrogenase
E4184_06965	COG0564	pseudouridine synthase activity
E4184_06995	COG1280	lysine exporter protein (LysE YggA)
E4184_07005	COG3263	regulation of cellular component size
E4184_07020	COG1876	peptidase activity
E4184_07025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4184_07030	COG1393	Belongs to the ArsC family
E4184_07040	COG3069	C4-dicarboxylate transmembrane transporter activity
E4184_07055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4184_07060	COG0017	Asparaginyl-tRNA synthetase
E4184_07080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4184_07085	COG0156	8-amino-7-oxononanoate synthase activity
E4184_07090	COG2226	methyltransferase
E4184_07090	COG1073	alpha beta
E4184_07095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4184_07100	COG0501	Belongs to the peptidase M48B family
E4184_07105	COG0633	Ferredoxin
E4184_07105	COG3217	Mosc domain protein beta barrel domain protein
E4184_07105	COG0633	Ferredoxin
E4184_07105	COG3217	Mosc domain protein beta barrel domain protein
E4184_07115	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4184_07115	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4184_07115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4184_07115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4184_07120	COG2841	Protein conserved in bacteria
E4184_07130	COG0534	Mate efflux family protein
E4184_07165	COG1309	transcriptional regulator
E4184_07180	COG0791	NLP P60 protein
E4184_07185	COG0583	DNA-binding transcription factor activity
E4184_07205	COG0500	methyltransferase
E4184_07210	COG4106	trans-aconitate 2-methyltransferase activity
E4184_07215	COG1801	Protein of unknown function DUF72
E4184_07225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4184_07230	COG0217	transcriptional regulatory protein
E4184_07240	COG1846	Transcriptional regulator
E4184_07240	COG1940	carbohydrate kinase activity
E4184_07245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4184_07250	COG0363	glucosamine-6-phosphate deaminase activity
E4184_07255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_07255	COG2190	(PTS) system
E4184_07255	COG1263	PTS System
E4184_07275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4184_07275	COG2010	Cytochrome c
E4184_07280	COG2080	2 iron, 2 sulfur cluster binding
E4184_07285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4184_07295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4184_07300	COG0735	belongs to the Fur family
E4184_07310	COG0716	FMN binding
E4184_07325	COG0596	Alpha beta hydrolase
E4184_07330	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4184_07335	COG0033	Phosphoglucomutase
E4184_07350	COG2951	lytic endotransglycosylase activity
E4184_07355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4184_07360	COG4136	ATPase activity
E4184_07370	COG4134	Bacterial extracellular solute-binding protein
E4184_07380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4184_07390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4184_07400	COG0729	surface antigen
E4184_07425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4184_07435	COG0741	lytic transglycosylase activity
E4184_07450	COG1607	acyl-coa hydrolase
E4184_07465	COG0741	lytic transglycosylase activity
E4184_07465	COG1388	LysM domain
E4184_07470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4184_07475	COG2226	methyltransferase
E4184_07480	COG0328	RNA-DNA hybrid ribonuclease activity
E4184_07485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4184_07505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4184_07510	COG0121	glutamine amidotransferase
E4184_07520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4184_07545	COG2197	response regulator
E4184_07550	COG3850	Histidine kinase
E4184_07555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4184_07560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4184_07570	COG0243	molybdopterin cofactor binding
E4184_07575	COG0437	4 iron, 4 sulfur cluster binding
E4184_07580	COG0348	domain, Protein
E4184_07590	COG3005	denitrification pathway
E4184_07595	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4184_07600	COG0315	cyclic pyranopterin monophosphate synthase activity
E4184_07605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4184_07610	COG0314	molybdopterin synthase activity
E4184_07625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4184_07630	COG0596	Alpha beta hydrolase
E4184_07635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4184_07640	COG0303	'Molybdopterin
E4184_07645	COG0302	gtp cyclohydrolase
E4184_07650	COG0840	transmembrane signaling receptor activity
E4184_07655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4184_07665	COG0583	DNA-binding transcription factor activity
E4184_07680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4184_07695	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4184_07710	COG1166	arginine decarboxylase activity
E4184_07725	COG1061	Type III restriction enzyme res subunit
E4184_07745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4184_07750	COG1187	pseudouridine synthase activity
E4184_07755	COG2807	transmembrane transport
E4184_07765	COG0583	DNA-binding transcription factor activity
E4184_07795	COG2979	Protein of unknown function (DUF533)
E4184_07805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4184_07815	COG1294	oxidase, subunit
E4184_07825	COG2814	Major facilitator Superfamily
E4184_07830	COG0656	L-ascorbic acid biosynthetic process
E4184_07855	COG0583	DNA-binding transcription factor activity
E4184_07860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4184_07865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4184_07870	COG2271	Major facilitator Superfamily
E4184_07875	COG1349	DNA-binding transcription factor activity
E4184_07885	COG0584	glycerophosphoryl diester phosphodiesterase
E4184_07890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4184_07895	COG0287	Prephenate dehydrogenase
E4184_07895	COG1605	Chorismate mutase
E4184_07905	COG3085	chromosome segregation
E4184_07910	COG4574	serine-type endopeptidase inhibitor activity
E4184_07930	COG1770	oligopeptidase
E4184_07940	COG3083	sulfuric ester hydrolase activity
E4184_07945	COG3082	Protein of unknown function (DUF1414)
E4184_07950	COG3081	Nucleoid-associated protein
E4184_07955	COG2182	Extracellular solute-binding protein
E4184_07960	COG1175	transmembrane transport
E4184_07965	COG3833	ABC-type maltose transport systems, permease component
E4184_07970	COG3842	ATPase activity
E4184_07995	COG0425	Belongs to the sulfur carrier protein TusA family
E4184_08000	COG4783	chaperone-mediated protein folding
E4184_08010	COG1393	Belongs to the ArsC family
E4184_08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_08030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4184_08035	COG2431	L-lysine efflux transmembrane transporter activity
E4184_08045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_08065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4184_08075	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4184_08110	COG3039	Transposase
E4184_08115	COG2373	Large extracellular alpha-helical protein
E4184_08120	COG4953	penicillin-binding protein 1C
E4184_08130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4184_08130	COG0301	tRNA thio-modification
E4184_08150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4184_08155	COG1334	flagellar protein FlaG
E4184_08185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4184_08195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4184_08215	COG0346	lactoylglutathione lyase activity
E4184_08220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4184_08230	COG4659	FMN binding
E4184_08235	COG4658	electron transport chain
E4184_08240	COG4656	Part of a membrane complex involved in electron transport
E4184_08245	COG2878	Part of a membrane complex involved in electron transport
E4184_08250	COG4657	Part of a membrane complex involved in electron transport
E4184_08255	COG0697	spore germination
E4184_08275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4184_08285	COG0436	Aminotransferase
E4184_08295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4184_08300	COG2027	D-alanyl-D-alanine carboxypeptidase
E4184_08305	COG1061	Type III restriction enzyme res subunit
E4184_08310	COG1566	PFAM secretion protein HlyD family protein
E4184_08320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4184_08320	COG3264	Mechanosensitive ion channel
E4184_08325	COG1966	Carbon starvation protein
E4184_08330	COG3279	Response regulator of the LytR AlgR family
E4184_08335	COG3275	phosphorelay sensor kinase activity
E4184_08345	COG1012	belongs to the aldehyde dehydrogenase family
E4184_08345	COG1454	alcohol dehydrogenase
E4184_08350	COG2095	MarC family integral membrane protein
E4184_08360	COG0601	transmembrane transport
E4184_08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4184_08370	COG0444	Belongs to the ABC transporter superfamily
E4184_08385	COG0861	Integral membrane protein TerC family
E4184_08390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4184_08400	COG1301	dicarboxylic acid transport
E4184_08415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4184_08430	COG0537	adenosine 5'-monophosphoramidase activity
E4184_08465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4184_08470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4184_08480	COG2354	Protein conserved in bacteria
E4184_08495	COG3150	esterase
E4184_08500	COG1252	NADH dehydrogenase
E4184_08510	COG0393	Putative heavy-metal-binding
E4184_08515	COG1368	sulfuric ester hydrolase activity
E4184_08525	COG0527	aspartate kinase activity
E4184_08530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4184_08530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4184_08535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4184_08595	COG1136	(ABC) transporter
E4184_08620	COG2814	Major facilitator Superfamily
E4184_08640	COG0493	'glutamate synthase
E4184_08640	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E4184_08645	COG0672	)-iron permease
E4184_08680	COG2308	Evidence 4 Homologs of previously reported genes of
E4184_08695	COG0659	secondary active sulfate transmembrane transporter activity
E4184_08760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4184_08820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4184_08885	COG2003	Belongs to the UPF0758 family
E4184_08930	COG5377	YqaJ viral recombinase family
E4184_08970	COG1160	GTP binding
E4184_09010	COG4584	PFAM Integrase catalytic
E4184_09055	COG3206	protein involved in exopolysaccharide biosynthesis
E4184_09055	COG0489	protein tyrosine kinase activity
E4184_09075	COG0438	transferase activity, transferring glycosyl groups
E4184_09100	COG1442	glycosyl transferase family 8
E4184_09120	COG3152	Membrane
E4184_09125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4184_09130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4184_09135	COG1845	cytochrome c oxidase, subunit III
E4184_09140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4184_09145	COG0109	protoheme IX farnesyltransferase activity
E4184_09150	COG2814	Major facilitator Superfamily
E4184_09185	COG1484	DNA-dependent DNA replication
E4184_09225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_09230	COG0842	Transport permease protein
E4184_09230	COG1129	ABC transporter
E4184_09235	COG0842	Transport permease protein
E4184_09250	COG3501	Rhs element vgr protein
E4184_09275	COG0582	viral genome integration into host DNA
E4184_09295	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4184_09300	COG0437	4 iron, 4 sulfur cluster binding
E4184_09305	COG5557	Pfam Polysulphide reductase, NrfD
E4184_09310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4184_09315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4184_09320	COG1773	rubredoxin
E4184_09335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4184_09345	COG1124	(ABC) transporter
E4184_09350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4184_09355	COG0375	protein maturation
E4184_09360	COG0309	Hydrogenase expression formation protein (HypE)
E4184_09370	COG0298	carbon dioxide binding
E4184_09375	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4184_09380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4184_09385	COG0326	Molecular chaperone. Has ATPase activity
E4184_09390	COG0563	adenylate kinase activity
E4184_09395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4184_09405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4184_09410	COG0840	transmembrane signaling receptor activity
E4184_09425	COG5001	Diguanylate cyclase
E4184_09425	COG3300	MHYT domain
E4184_09430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4184_09450	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4184_09455	COG1535	isochorismatase
E4184_09455	COG3433	isochorismatase activity
E4184_09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4184_09465	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_09480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4184_09485	COG2977	Belongs to the P-Pant transferase superfamily
E4184_09490	COG1120	ATPase activity
E4184_09495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4184_09500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4184_09505	COG4771	TonB-dependent receptor
E4184_09530	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4184_09530	COG0644	oxidoreductase
E4184_09535	COG0644	oxidoreductase
E4184_09535	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4184_09540	COG0644	oxidoreductase
E4184_09540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4184_09560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4184_09565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4184_09570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4184_09575	COG0861	Integral membrane protein TerC family
E4184_09590	COG1022	Amp-dependent synthetase and ligase
E4184_09595	COG0295	cytidine deaminase activity
E4184_09600	COG1346	cytolysis
E4184_09605	COG1380	Effector of murein hydrolase LrgA
E4184_09610	COG3345	alpha-galactosidase
E4184_09620	COG2925	Exonuclease
E4184_09625	COG0582	viral genome integration into host DNA
E4184_09670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4184_09700	COG1396	sequence-specific DNA binding
E4184_09745	COG3646	Phage regulatory protein
E4184_09915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4184_09925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4184_09930	COG0436	Aminotransferase
E4184_09935	COG0583	DNA-binding transcription factor activity
E4184_09940	COG2160	L-arabinose isomerase activity
E4184_09950	COG1069	ribulokinase activity
E4184_09955	COG1879	ABC-type sugar transport system periplasmic component
E4184_09960	COG1129	ABC transporter
E4184_09965	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4184_09975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4184_09980	COG0254	rRNA binding
E4184_09995	COG1451	nucleotide metabolic process
E4184_10010	COG3069	C4-dicarboxylate transmembrane transporter activity
E4184_10020	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4184_10020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4184_10025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4184_10050	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4184_10055	COG1053	succinate dehydrogenase
E4184_10065	COG0567	Dehydrogenase, E1 component
E4184_10070	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4184_10075	COG0045	succinate-CoA ligase (ADP-forming) activity
E4184_10080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4184_10090	COG2983	Belongs to the UPF0260 family
E4184_10095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4184_10105	COG3842	ATPase activity
E4184_10110	COG1840	ABC-type Fe3 transport system, periplasmic component
E4184_10120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4184_10130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_10135	COG1882	Formate acetyltransferase
E4184_10140	COG2116	formate transmembrane transporter activity
E4184_10145	COG1944	ATP diphosphatase activity
E4184_10165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4184_10170	COG1278	Cold shock
E4184_10175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4184_10180	COG0542	response to heat
E4184_10185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4184_10190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4184_10195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4184_10200	COG3134	Outer membrane lipoprotein
E4184_10205	COG3706	GGDEF domain
E4184_10210	COG0492	ferredoxin-NADP+ reductase activity
E4184_10215	COG0686	Belongs to the AlaDH PNT family
E4184_10225	COG0531	amino acid
E4184_10225	COG1674	ftsk spoiiie
E4184_10230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4184_10235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4184_10240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4184_10245	COG1286	toxin biosynthetic process
E4184_10250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4184_10255	COG2723	6-phospho-beta-galactosidase activity
E4184_10260	COG1263	PTS System
E4184_10260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_10265	COG1609	Transcriptional regulator
E4184_10275	COG4172	Belongs to the ABC transporter superfamily
E4184_10285	COG4171	peptide transport system, permease
E4184_10290	COG4168	peptide transport system, permease
E4184_10300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4184_10305	COG1842	Phage shock protein A
E4184_10320	COG3106	COG3106 Predicted ATPase
E4184_10325	COG3768	UPF0283 membrane protein
E4184_10335	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4184_10350	COG2199	diguanylate cyclase activity
E4184_10355	COG2885	chlorophyll binding
E4184_10365	COG1570	exodeoxyribonuclease VII activity
E4184_10375	COG1874	Beta-galactosidase
E4184_10375	COG0366	Alpha amylase catalytic
E4184_10385	COG0517	IMP dehydrogenase activity
E4184_10385	COG0516	GMP reductase activity
E4184_10390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4184_10390	COG0519	Catalyzes the synthesis of GMP from XMP
E4184_10420	COG2062	phosphohistidine phosphatase, SixA
E4184_10430	COG0697	spore germination
E4184_10435	COG4166	transmembrane transport
E4184_10440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4184_10445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4184_10455	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4184_10460	COG1136	(ABC) transporter
E4184_10465	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4184_10485	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4184_10490	COG0740	serine-type endopeptidase activity
E4184_10495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4184_10500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4184_10505	COG0776	regulation of translation
E4184_10510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4184_10515	COG0488	(ABC) transporter
E4184_10520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4184_10525	COG3162	membrane
E4184_10540	COG1024	Enoyl-CoA hydratase
E4184_10545	COG1115	amino acid carrier protein
E4184_10560	COG1584	GPR1 FUN34 yaaH family protein
E4184_10585	COG1024	Enoyl-CoA hydratase
E4184_10595	COG1960	acyl-CoA dehydrogenase activity
E4184_10605	COG1960	acyl-CoA dehydrogenase activity
E4184_10610	COG1024	Enoyl-CoA hydratase
E4184_10615	COG1024	Enoyl-CoA hydratase
E4184_10630	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_10640	COG0730	response to heat
E4184_10675	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4184_10680	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4184_10685	COG1129	ABC transporter
E4184_10695	COG5433	transposase activity
E4184_10705	COG0583	DNA-binding transcription factor activity
E4184_10720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4184_10725	COG0243	molybdopterin cofactor binding
E4184_10735	COG3706	GGDEF domain
E4184_10740	COG0583	DNA-binding transcription factor activity
E4184_10745	COG2723	6-phospho-beta-galactosidase activity
E4184_10750	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_10755	COG0583	DNA-binding transcription factor activity
E4184_10770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4184_10775	COG0673	inositol 2-dehydrogenase activity
E4184_10780	COG0583	DNA-binding transcription factor activity
E4184_10790	COG1560	Kdo2-lipid A biosynthetic process
E4184_10795	COG1560	Kdo2-lipid A biosynthetic process
E4184_10820	COG0417	DNA replication proofreading
E4184_10850	COG0534	Mate efflux family protein
E4184_10860	COG0307	riboflavin synthase, alpha
E4184_10870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_10875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4184_10880	COG0697	spore germination
E4184_10885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4184_10920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4184_10925	COG3099	Belongs to the UPF0263 family
E4184_10930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4184_10935	COG2894	cell division
E4184_10940	COG0850	regulation of cytokinetic process
E4184_10945	COG3100	YcgL domain-containing protein
E4184_10950	COG2951	lytic endotransglycosylase activity
E4184_10955	COG1760	l-serine dehydratase
E4184_10965	COG1760	l-serine dehydratase
E4184_10970	COG3123	guanosine phosphorylase activity
E4184_10990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4184_10995	COG2067	long-chain fatty acid transport protein
E4184_11000	COG2067	long-chain fatty acid transport protein
E4184_11020	COG2304	oxidoreductase activity
E4184_11045	COG0714	Associated with various cellular activities
E4184_11050	COG0183	Belongs to the thiolase family
E4184_11055	COG1024	Enoyl-CoA hydratase
E4184_11055	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4184_11065	COG4681	YaeQ
E4184_11090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4184_11110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_11125	COG3134	Outer membrane lipoprotein
E4184_11130	COG0318	PFAM AMP-dependent synthetase and ligase
E4184_11160	COG0140	phosphoribosyl-ATP diphosphatase activity
E4184_11160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4184_11165	COG0107	imidazoleglycerol-phosphate synthase activity
E4184_11170	COG2205	protein histidine kinase activity
E4184_11170	COG2198	Histidine kinase
E4184_11170	COG0784	Response regulator, receiver
E4184_11180	COG3437	response regulator, receiver
E4184_11185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4184_11190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4184_11195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4184_11195	COG0131	Imidazoleglycerol-phosphate dehydratase
E4184_11200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4184_11205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4184_11210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4184_11220	COG1199	ATP-dependent helicase activity
E4184_11225	COG1214	PFAM Peptidase M22, glycoprotease
E4184_11235	COG0596	Alpha beta hydrolase
E4184_11240	COG0318	PFAM AMP-dependent synthetase and ligase
E4184_11255	COG0697	spore germination
E4184_11265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4184_11270	COG2832	Protein of unknown function (DUF454)
E4184_11275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4184_11285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4184_11290	COG1335	isochorismatase
E4184_11300	COG0583	DNA-binding transcription factor activity
E4184_11310	COG2197	response regulator
E4184_11315	COG0517	IMP dehydrogenase activity
E4184_11315	COG0617	tRNA 3'-terminal CCA addition
E4184_11315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4184_11320	COG1643	Atp-dependent helicase
E4184_11330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4184_11335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4184_11340	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4184_11345	COG0709	Synthesizes selenophosphate from selenide and ATP
E4184_11360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4184_11365	COG0840	transmembrane signaling receptor activity
E4184_11370	COG1254	Belongs to the acylphosphatase family
E4184_11380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4184_11380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4184_11385	COG0489	protein tyrosine kinase activity
E4184_11390	COG0572	uridine kinase
E4184_11395	COG0717	Belongs to the dCTP deaminase family
E4184_11400	COG0306	phosphate transporter
E4184_11405	COG1530	ribonuclease E activity
E4184_11420	COG0424	maF-like protein
E4184_11430	COG1399	metal-binding, possibly nucleic acid-binding protein
E4184_11435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4184_11440	COG0416	fatty acid biosynthetic process
E4184_11445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4184_11455	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_11460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4184_11465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4184_11470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4184_11480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4184_11485	COG0470	DNA polymerase III
E4184_11490	COG0084	hydrolase, TatD family'
E4184_11505	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4184_11505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4184_11510	COG3008	intermembrane lipid transfer
E4184_11515	COG2995	paraquat-inducible protein a
E4184_11525	COG3141	response to X-ray
E4184_11535	COG1067	ATP-dependent peptidase activity
E4184_11540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4184_11565	COG0116	Belongs to the methyltransferase superfamily
E4184_11565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4184_11575	COG0167	dihydroorotate dehydrogenase activity
E4184_11580	COG2902	Dehydrogenase
E4184_11590	COG0308	aminopeptidase N
E4184_11600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4184_11605	COG1956	GAF domain-containing protein
E4184_11615	COG3278	Belongs to the heme-copper respiratory oxidase family
E4184_11630	COG2010	Cytochrome c
E4184_11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4184_11660	COG0589	response to stress
E4184_11665	COG0037	tRNA processing
E4184_11685	COG1869	D-ribose catabolic process
E4184_11690	COG1129	ABC transporter
E4184_11695	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4184_11700	COG1879	ABC-type sugar transport system periplasmic component
E4184_11705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4184_11710	COG1609	Transcriptional regulator
E4184_11715	COG5001	Diguanylate cyclase
E4184_11715	COG3300	MHYT domain
E4184_11740	COG0784	Response regulator, receiver
E4184_11740	COG2205	protein histidine kinase activity
E4184_11745	COG0776	regulation of translation
E4184_11750	COG0072	phenylalanine-tRNA ligase activity
E4184_11750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4184_11755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4184_11760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4184_11765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4184_11770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4184_11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4184_11800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4184_11810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4184_11815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4184_11820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4184_11825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4184_11830	COG3313	Fe-S protein
E4184_11835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4184_11835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_11835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_11840	COG1105	Belongs to the carbohydrate kinase PfkB family
E4184_11845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_11845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_11850	COG1609	Transcriptional regulator
E4184_11855	COG0814	amino acid
E4184_11860	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4184_11865	COG0513	Belongs to the DEAD box helicase family
E4184_11875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4184_11880	COG2890	protein-(glutamine-N5) methyltransferase activity
E4184_11885	COG2840	Smr protein MutS2
E4184_11920	COG2824	Alkylphosphonate utilization operon protein PhnA
E4184_11950	COG0588	phosphoglycerate mutase activity
E4184_11975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4184_11980	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4184_11990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4184_11995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4184_12005	COG0205	6-phosphofructokinase activity
E4184_12010	COG1473	amidohydrolase
E4184_12015	COG1011	Hydrolase
E4184_12020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4184_12070	COG3593	DNA synthesis involved in DNA repair
E4184_12085	COG0583	DNA-binding transcription factor activity
E4184_12090	COG0730	response to heat
E4184_12105	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4184_12115	COG0386	Belongs to the glutathione peroxidase family
E4184_12120	COG0513	Belongs to the DEAD box helicase family
E4184_12135	COG1742	UPF0060 membrane protein
E4184_12160	COG2329	Antibiotic biosynthesis monooxygenase
E4184_12165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4184_12195	COG2501	S4 domain
E4184_12220	COG1132	(ABC) transporter
E4184_12225	COG1132	(ABC) transporter
E4184_12235	COG3118	belongs to the thioredoxin family
E4184_12240	COG0471	metal ion transport
E4184_12250	COG0058	SHG alpha-glucan phosphorylase activity
E4184_12280	COG0814	amino acid
E4184_12285	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4184_12290	COG0514	ATP-dependent DNA helicase (RecQ)
E4184_12295	COG2766	serine protein kinase
E4184_12300	COG2718	Belongs to the UPF0229 family
E4184_12305	COG2719	SpoVR family
E4184_12320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4184_12330	COG0586	Pfam SNARE associated Golgi protein
E4184_12340	COG0556	nucleotide-excision repair
E4184_12355	COG0569	domain protein
E4184_12355	COG2985	domain, Protein
E4184_12360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4184_12390	COG4565	transcriptional regulatory protein
E4184_12395	COG3290	protein histidine kinase activity
E4184_12400	COG1940	carbohydrate kinase activity
E4184_12400	COG1846	Transcriptional regulator
E4184_12410	COG3012	SEC-C Motif Domain Protein
E4184_12415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4184_12420	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4184_12425	COG0247	lactate metabolic process
E4184_12440	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4184_12445	COG0437	4 iron, 4 sulfur cluster binding
E4184_12450	COG3301	Polysulphide reductase, NrfD
E4184_12455	COG1138	Cytochrome C-type biogenesis protein
E4184_12465	COG4235	cytochrome complex assembly
E4184_12465	COG3088	subunit of a heme lyase
E4184_12480	COG3046	protein related to deoxyribodipyrimidine photolyase
E4184_12485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4184_12500	COG0517	IMP dehydrogenase activity
E4184_12510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4184_12515	COG0583	DNA-binding transcription factor activity
E4184_12525	COG4774	siderophore transport
E4184_12530	COG3706	GGDEF domain
E4184_12535	COG2207	Transcriptional regulator
E4184_12535	COG3708	Transcriptional regulator
E4184_12545	COG0583	DNA-binding transcription factor activity
E4184_12550	COG2910	NAD(P)H-binding
E4184_12565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4184_12595	COG3039	Transposase
E4184_12660	COG3550	peptidyl-serine autophosphorylation
E4184_12675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4184_12700	COG1435	thymidine kinase activity
E4184_12710	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4184_12715	COG2096	Adenosyltransferase
E4184_12720	COG3530	Putative quorum-sensing-regulated virulence factor
E4184_12725	COG0602	queuosine metabolic process
E4184_12730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4184_12750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4184_12760	COG0776	regulation of translation
E4184_12765	COG0539	negative regulation of cytoplasmic translation
E4184_12770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4184_12775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4184_12785	COG2814	Major facilitator Superfamily
E4184_12800	COG0778	Nitroreductase
E4184_12805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4184_12810	COG5001	Diguanylate cyclase
E4184_12810	COG3300	MHYT domain
E4184_12820	COG0583	DNA-binding transcription factor activity
E4184_12825	COG3437	response regulator, receiver
E4184_12850	COG4989	oxidoreductase activity
E4184_12855	COG0724	RNA recognition motif
E4184_12875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4184_12890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4184_12895	COG1360	Flagellar Motor Protein
E4184_12900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4184_12905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4184_12910	COG0649	NAD binding
E4184_12910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4184_12925	COG1034	ATP synthesis coupled electron transport
E4184_12930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4184_12935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4184_12940	COG0839	Belongs to the complex I subunit 6 family
E4184_12945	COG0713	ATP synthesis coupled electron transport
E4184_12955	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4184_12960	COG1007	ATP synthesis coupled electron transport
E4184_12970	COG0047	phosphoribosylformylglycinamidine synthase activity
E4184_12970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4184_12975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4184_12985	COG1645	bacterial-type flagellum-dependent swarming motility
E4184_12990	COG1160	GTP binding
E4184_12995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4184_13000	COG2976	Protein conserved in bacteria
E4184_13005	COG0124	histidyl-tRNA synthetase
E4184_13010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4184_13025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4184_13030	COG0105	UTP biosynthetic process
E4184_13035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4184_13045	COG0633	Ferredoxin
E4184_13050	COG0443	Heat shock 70 kDa protein
E4184_13055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4184_13065	COG0822	iron-sulfur transferase activity
E4184_13070	COG1104	cysteine desulfurase activity
E4184_13090	COG3154	lipid carrier protein
E4184_13095	COG0826	peptidase U32
E4184_13100	COG0826	peptidase U32
E4184_13115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4184_13120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4184_13125	COG1862	Preprotein translocase
E4184_13130	COG0343	queuine tRNA-ribosyltransferase activity
E4184_13135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4184_13140	COG0517	IMP dehydrogenase activity
E4184_13150	COG3634	alkyl hydroperoxide reductase activity
E4184_13165	COG2203	Gaf domain
E4184_13165	COG2199	diguanylate cyclase activity
E4184_13190	COG5642	Protein of unknown function (DUF2384)
E4184_13240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4184_13265	COG5433	transposase activity
E4184_13285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4184_13285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4184_13290	COG0509	glycine decarboxylation via glycine cleavage system
E4184_13295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4184_13300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4184_13305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4184_13325	COG1609	Transcriptional regulator
E4184_13330	COG1129	ABC transporter
E4184_13335	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4184_13340	COG1879	ABC-type sugar transport system periplasmic component
E4184_13350	COG0673	inositol 2-dehydrogenase activity
E4184_13355	COG2814	Major facilitator Superfamily
E4184_13365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4184_13370	COG0601	transmembrane transport
E4184_13380	COG0625	glutathione transferase activity
E4184_13395	COG0483	inositol monophosphate 1-phosphatase activity
E4184_13405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4184_13410	COG2056	Na+-H+ antiporter family
E4184_13415	COG3300	MHYT domain
E4184_13415	COG5001	Diguanylate cyclase
E4184_13425	COG0513	Belongs to the DEAD box helicase family
E4184_13430	COG2050	protein possibly involved in aromatic compounds catabolism
E4184_13440	COG0247	lactate metabolic process
E4184_13440	COG0277	FAD linked oxidase domain protein
E4184_13455	COG5433	transposase activity
E4184_13465	COG1253	flavin adenine dinucleotide binding
E4184_13470	COG1902	pentaerythritol trinitrate reductase activity
E4184_13480	COG0647	UMP catabolic process
E4184_13490	COG0367	asparagine synthase
E4184_13500	COG0625	glutathione transferase activity
E4184_13510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4184_13525	COG0564	pseudouridine synthase activity
E4184_13530	COG3706	GGDEF domain
E4184_13540	COG0318	PFAM AMP-dependent synthetase and ligase
E4184_13585	COG2855	membrane
E4184_13595	COG2814	Major facilitator Superfamily
E4184_13600	COG3246	L-lysine catabolic process to acetate
E4184_13605	COG2175	clavaminate synthase activity
E4184_13615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4184_13640	COG0670	Belongs to the BI1 family
E4184_13650	COG1289	transmembrane transporter activity
E4184_13655	COG2920	part of a sulfur-relay system
E4184_13660	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4184_13665	COG0285	dihydrofolate synthase activity
E4184_13670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4184_13675	COG0101	tRNA pseudouridine synthase activity
E4184_13685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4184_13690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4184_13695	COG0671	phosphoesterase, PA-phosphatase related
E4184_13700	COG1464	Belongs to the NlpA lipoprotein family
E4184_13715	COG1119	ATPase activity
E4184_13730	COG0574	Belongs to the PEP-utilizing enzyme family
E4184_13730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4184_13735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4184_13790	COG1242	4 iron, 4 sulfur cluster binding
E4184_13795	COG0070	glutamate synthase
E4184_13795	COG0069	glutamate synthase activity
E4184_13795	COG0067	glutamate synthase
E4184_13800	COG0493	'glutamate synthase
E4184_13815	COG0513	Belongs to the DEAD box helicase family
E4184_13840	COG3706	GGDEF domain
E4184_13845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4184_13850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4184_13855	COG0505	Belongs to the CarA family
E4184_13860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4184_13870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4184_13875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4184_13880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4184_13885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4184_13890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4184_13940	COG0023	Translation Initiation Factor
E4184_13945	COG2119	membrane
E4184_13980	COG2199	diguanylate cyclase activity
E4184_13980	COG2203	Gaf domain
E4184_14015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4184_14020	COG2261	transglycosylase associated protein
E4184_14025	COG0625	glutathione transferase activity
E4184_14065	COG5433	transposase activity
E4184_14080	COG3039	Transposase
E4184_14145	COG0322	excinuclease ABC activity
E4184_14150	COG2197	response regulator
E4184_14155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4184_14160	COG2835	tetraacyldisaccharide 4'-kinase activity
E4184_14165	COG1663	tetraacyldisaccharide 4'-kinase activity
E4184_14170	COG1132	(ABC) transporter
E4184_14175	COG0658	competence protein
E4184_14175	COG2333	competence protein COMEC
E4184_14190	COG0433	COG0433 Predicted ATPase
E4184_14195	COG1448	Aminotransferase
E4184_14210	COG1199	ATP-dependent helicase activity
E4184_14220	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4184_14225	COG0477	Major facilitator Superfamily
E4184_14230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4184_14260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4184_14265	COG2197	response regulator
E4184_14275	COG2271	Major facilitator Superfamily
E4184_14285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_14290	COG0765	amino acid transport
E4184_14295	COG1126	abc transporter atp-binding protein
E4184_14305	COG0531	amino acid
E4184_14320	COG1253	flavin adenine dinucleotide binding
E4184_14335	COG0581	inorganic phosphate transmembrane transporter activity
E4184_14340	COG0573	inorganic phosphate transmembrane transporter activity
E4184_14360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4184_14380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4184_14385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4184_14390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4184_14395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4184_14405	COG3852	Histidine kinase
E4184_14420	COG2716	regulation of RNA biosynthetic process
E4184_14425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4184_14435	COG2239	Acts as a magnesium transporter
E4184_14460	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4184_14460	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4184_14465	COG1706	bacterial-type flagellum-dependent cell motility
E4184_14470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4184_14485	COG1749	Flagellar hook protein flgE
E4184_14500	COG1815	bacterial-type flagellum-dependent cell motility
E4184_14505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4184_14510	COG0835	chemotaxis
E4184_14510	COG0784	Response regulator, receiver
E4184_14515	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4184_14530	COG0622	Phosphoesterase
E4184_14535	COG4166	transmembrane transport
E4184_14545	COG1187	pseudouridine synthase activity
E4184_14560	COG0697	spore germination
E4184_14590	COG1278	Cold shock
E4184_14630	COG3132	Protein of unknown function, DUF480
E4184_14650	COG3039	Transposase
E4184_14660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4184_14675	COG0529	Catalyzes the synthesis of activated sulfate
E4184_14680	COG0471	metal ion transport
E4184_14680	COG3273	potassium ion transport
E4184_14685	COG2895	sulfate adenylyltransferase (ATP) activity
E4184_14705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4184_14710	COG1216	Glycosyl transferase, family 2
E4184_14735	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4184_14750	COG2205	protein histidine kinase activity
E4184_14755	COG0837	glucose binding
E4184_14760	COG1737	Transcriptional regulator
E4184_14765	COG0469	pyruvate kinase activity
E4184_14780	COG1960	acyl-CoA dehydrogenase activity
E4184_14790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4184_14805	COG5377	YqaJ viral recombinase family
E4184_14825	COG2003	Belongs to the UPF0758 family
E4184_14845	COG5433	transposase activity
E4184_14875	COG3385	transposase activity
E4184_14940	COG0625	glutathione transferase activity
E4184_14945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4184_14955	COG0583	DNA-binding transcription factor activity
E4184_14965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4184_14980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4184_15000	COG1846	Transcriptional regulator
E4184_15005	COG0583	DNA-binding transcription factor activity
E4184_15015	COG2948	multi-organism process
E4184_15025	COG4983	Phage plasmid primase, P4 family domain protein
E4184_15035	COG0582	viral genome integration into host DNA
E4184_15040	COG5433	transposase activity
E4184_15045	COG0582	viral genome integration into host DNA
E4184_15055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4184_15065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_15070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_15075	COG1309	transcriptional regulator
E4184_15090	COG1946	Acyl-CoA thioesterase
E4184_15100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4184_15110	COG0009	L-threonylcarbamoyladenylate synthase
E4184_15115	COG0613	PHP domain protein
E4184_15125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4184_15130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4184_15130	COG0512	Glutamine amidotransferase of anthranilate synthase
E4184_15135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4184_15140	COG0134	indole-3-glycerol-phosphate synthase activity
E4184_15140	COG0135	phosphoribosylanthranilate isomerase activity
E4184_15145	COG0133	tryptophan synthase activity
E4184_15150	COG0159	tryptophan synthase activity
E4184_15185	COG1988	membrane-bound metal-dependent
E4184_15190	COG1396	sequence-specific DNA binding
E4184_15195	COG3550	peptidyl-serine autophosphorylation
E4184_15215	COG0583	DNA-binding transcription factor activity
E4184_15225	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4184_15230	COG2814	Major facilitator Superfamily
E4184_15240	COG0109	protoheme IX farnesyltransferase activity
E4184_15245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4184_15250	COG1845	cytochrome c oxidase, subunit III
E4184_15255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4184_15260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4184_15265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4184_15270	COG0583	DNA-binding transcription factor activity
E4184_15300	COG0071	Belongs to the small heat shock protein (HSP20) family
E4184_15315	COG0708	Exodeoxyribonuclease III
E4184_15325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_15330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_15345	COG0095	Lipoate-protein ligase
E4184_15350	COG1136	(ABC) transporter
E4184_15350	COG0577	efflux transmembrane transporter activity
E4184_15355	COG1136	(ABC) transporter
E4184_15355	COG0577	efflux transmembrane transporter activity
E4184_15360	COG1136	(ABC) transporter
E4184_15360	COG0577	efflux transmembrane transporter activity
E4184_15365	COG1566	PFAM secretion protein HlyD family protein
E4184_15380	COG2391	methyltransferase activity
E4184_15390	COG0640	Transcriptional regulator
E4184_15405	COG1285	pathogenesis
E4184_15435	COG0484	heat shock protein binding
E4184_15440	COG0443	Heat shock 70 kDa protein
E4184_15445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4184_15450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4184_15455	COG3706	GGDEF domain
E4184_15460	COG0497	DNA recombination
E4184_15465	COG1227	inorganic diphosphatase activity
E4184_15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4184_15480	COG0577	efflux transmembrane transporter activity
E4184_15480	COG1136	(ABC) transporter
E4184_15490	COG2375	cellular response to nickel ion
E4184_15495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4184_15500	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4184_15505	COG0583	DNA-binding transcription factor activity
E4184_15510	COG2610	gluconate transmembrane transporter activity
E4184_15515	COG3048	D-serine ammonia-lyase activity
E4184_15525	COG0538	isocitrate dehydrogenase activity
E4184_15530	COG2207	Transcriptional regulator
E4184_15535	COG1482	cell wall glycoprotein biosynthetic process
E4184_15550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_15555	COG5492	domain, Protein
E4184_15555	COG4932	domain protein
E4184_15565	COG0477	Major facilitator Superfamily
E4184_15565	COG2814	Major facilitator Superfamily
E4184_15570	COG0457	Tetratricopeptide repeat
E4184_15575	COG1940	carbohydrate kinase activity
E4184_15585	COG3039	Transposase
E4184_15595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_15595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_15595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_15605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4184_15625	COG0482	sulfurtransferase activity
E4184_15630	COG2915	High frequency lysogenization protein hflD homolog
E4184_15635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4184_15640	COG2850	peptidyl-arginine hydroxylation
E4184_15645	COG0469	pyruvate kinase activity
E4184_15650	COG3264	Mechanosensitive ion channel
E4184_15650	COG1196	nuclear chromosome segregation
E4184_15655	COG0582	viral genome integration into host DNA
E4184_15725	COG2706	6-phosphogluconolactonase activity
E4184_15750	COG0281	malic enzyme
E4184_15755	COG0746	molybdenum cofactor guanylyltransferase activity
E4184_15760	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4184_15765	COG1289	transmembrane transporter activity
E4184_15770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4184_15800	COG3220	belongs to the UPF0276 family
E4184_15815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4184_15845	COG4319	ketosteroid isomerase
E4184_15850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4184_15855	COG0083	homoserine kinase activity
E4184_15870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4184_15875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4184_15890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4184_15900	COG0745	RESPONSE REGULATOR receiver
E4184_15915	COG4988	ABC transporter
E4184_15920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4184_15940	COG1720	tRNA m6t6A37 methyltransferase activity
E4184_15955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4184_15960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4184_15965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_15975	COG2190	(PTS) system
E4184_15980	COG3038	cytochrome b561
E4184_15990	COG0420	3'-5' exonuclease activity
E4184_15995	COG0456	acetyltransferase
E4184_16000	COG2974	May be involved in recombination
E4184_16015	COG4651	solute:proton antiporter activity
E4184_16015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4184_16050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4184_16055	COG1396	sequence-specific DNA binding
E4184_16055	COG1917	Cupin 2, conserved barrel domain protein
E4184_16070	COG0531	amino acid
E4184_16075	COG0531	amino acid
E4184_16085	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4184_16095	COG3384	dioxygenase
E4184_16100	COG2205	protein histidine kinase activity
E4184_16100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_16125	COG2205	protein histidine kinase activity
E4184_16125	COG0784	Response regulator, receiver
E4184_16175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4184_16185	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4184_16200	COG4263	nitrous-oxide reductase activity
E4184_16205	COG0348	domain, Protein
E4184_16205	COG3901	Regulator of nitric oxide reductase transcription
E4184_16220	COG1388	LysM domain
E4184_16220	COG1376	ErfK ybiS ycfS ynhG family protein
E4184_16235	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4184_16240	COG0791	NLP P60 protein
E4184_16250	COG3118	belongs to the thioredoxin family
E4184_16260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4184_16265	COG0788	formyltetrahydrofolate deformylase activity
E4184_16290	COG1196	nuclear chromosome segregation
E4184_16290	COG0741	lytic transglycosylase activity
E4184_16290	COG0739	heme binding
E4184_16295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4184_16300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4184_16305	COG0673	inositol 2-dehydrogenase activity
E4184_16325	COG3039	Transposase
E4184_16330	COG1032	radical SAM domain protein
E4184_16335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4184_16345	COG3706	GGDEF domain
E4184_16350	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4184_16355	COG0733	neurotransmitter:sodium symporter activity
E4184_16385	COG0281	malic enzyme
E4184_16395	COG0534	Mate efflux family protein
E4184_16415	COG2233	PERMEase
E4184_16425	COG0095	Lipoate-protein ligase
E4184_16430	COG1115	amino acid carrier protein
E4184_16435	COG0019	diaminopimelate decarboxylase activity
E4184_16445	COG0678	peroxiredoxin activity
E4184_16450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4184_16460	COG1126	abc transporter atp-binding protein
E4184_16465	COG0765	amino acid transport
E4184_16470	COG4597	amino acid ABC transporter
E4184_16475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4184_16495	COG0545	Peptidyl-prolyl cis-trans isomerase
E4184_16510	COG3142	Participates in the control of copper homeostasis
E4184_16515	COG1940	carbohydrate kinase activity
E4184_16540	COG0745	RESPONSE REGULATOR receiver
E4184_16545	COG0346	lactoylglutathione lyase activity
E4184_16550	COG3706	GGDEF domain
E4184_16555	COG3284	Transcriptional regulator
E4184_16560	COG1012	belongs to the aldehyde dehydrogenase family
E4184_16570	COG0697	spore germination
E4184_16580	COG3290	protein histidine kinase activity
E4184_16585	COG0281	malic enzyme
E4184_16600	COG1566	PFAM secretion protein HlyD family protein
E4184_16630	COG0602	queuosine metabolic process
E4184_16635	COG1328	CTP reductase activity
E4184_16645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4184_16650	COG3115	cell septum assembly
E4184_16655	COG1196	nuclear chromosome segregation
E4184_16665	COG2860	membrane
E4184_16675	COG3108	Peptidase M15
E4184_16680	COG2989	Protein conserved in bacteria
E4184_16695	COG0463	Glycosyl transferase, family 2
E4184_16710	COG0366	Alpha amylase catalytic
E4184_16750	COG3706	GGDEF domain
E4184_16755	COG0037	tRNA processing
E4184_16760	COG3590	peptidase
E4184_16775	COG0488	(ABC) transporter
E4184_16785	COG0531	amino acid
E4184_16795	COG0675	Transposase, IS605 OrfB family
E4184_16810	COG0583	DNA-binding transcription factor activity
E4184_16820	COG0825	malonyl-CoA metabolic process
E4184_16830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4184_16835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4184_16840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4184_16845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4184_16850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4184_16865	COG0750	zinc metalloprotease
E4184_16870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4184_16875	COG0575	Belongs to the CDS family
E4184_16880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4184_16885	COG0233	cytoplasmic translational termination
E4184_16890	COG0528	UMP kinase activity
E4184_16895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4184_16900	COG0052	Belongs to the universal ribosomal protein uS2 family
E4184_16905	COG0024	Methionine aminopeptidase
E4184_16910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4184_16915	COG2171	N-acyltransferase activity
E4184_16925	COG1263	PTS System
E4184_16925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_16945	COG0564	pseudouridine synthase activity
E4184_16950	COG3098	single-species biofilm formation
E4184_16975	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4184_16985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4184_16985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4184_16995	COG3706	GGDEF domain
E4184_17000	COG1611	Belongs to the LOG family
E4184_17005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4184_17015	COG0473	3-isopropylmalate dehydrogenase activity
E4184_17025	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4184_17030	COG2363	Small membrane protein
E4184_17040	COG0583	DNA-binding transcription factor activity
E4184_17045	COG0840	transmembrane signaling receptor activity
E4184_17050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4184_17065	COG1477	protein flavinylation
E4184_17070	COG2871	sodium ion transport
E4184_17075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4184_17080	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4184_17085	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4184_17090	COG1805	sodium ion transport
E4184_17095	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4184_17105	COG0271	Belongs to the BolA IbaG family
E4184_17110	COG2813	Specifically methylates the guanine in position
E4184_17120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4184_17130	COG2211	Major facilitator Superfamily
E4184_17135	COG3248	Nucleoside-binding outer membrane protein
E4184_17140	COG1666	GTP binding
E4184_17145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4184_17200	COG1393	Belongs to the ArsC family
E4184_17205	COG0798	PFAM Bile acid sodium symporter
E4184_17215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4184_17240	COG0582	viral genome integration into host DNA
E4184_17250	COG3311	Transcriptional regulator
E4184_17340	COG2003	Belongs to the UPF0758 family
E4184_17420	COG1136	(ABC) transporter
E4184_17430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4184_17440	COG2314	TM2 domain
E4184_17460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4184_17465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4184_17470	COG1151	hydroxylamine reductase activity
E4184_17475	COG0783	Belongs to the Dps family
E4184_17500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4184_17515	COG0300	oxidoreductase activity
E4184_17530	COG0789	Transcriptional regulator
E4184_17535	COG3272	Protein of unknown function (DUF1722)
E4184_17560	COG1605	Chorismate mutase
E4184_17560	COG0077	Prephenate dehydratase
E4184_17595	COG2133	pyrroloquinoline quinone binding
E4184_17605	COG1349	DNA-binding transcription factor activity
E4184_17610	COG2084	Dehydrogenase
E4184_17615	COG3395	kinase activity
E4184_17620	COG0235	Class ii aldolase
E4184_17625	COG3622	Belongs to the hyi family
E4184_17630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4184_17635	COG2610	gluconate transmembrane transporter activity
E4184_17655	COG0300	oxidoreductase activity
E4184_17680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4184_17700	COG3813	Protein conserved in bacteria
E4184_17715	COG5433	transposase activity
E4184_17725	COG0826	peptidase U32
E4184_17735	COG1280	lysine exporter protein (LysE YggA)
E4184_17745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4184_17815	COG1566	PFAM secretion protein HlyD family protein
E4184_17825	COG0114	fumarate hydratase activity
E4184_17835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4184_17835	COG0506	proline dehydrogenase activity
E4184_17835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4184_17840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4184_17855	COG0737	Belongs to the 5'-nucleotidase family
E4184_17875	COG2204	response regulator
E4184_17880	COG0545	Peptidyl-prolyl cis-trans isomerase
E4184_17895	COG1047	Peptidyl-prolyl cis-trans
E4184_17900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4184_17910	COG0835	chemotaxis
E4184_17910	COG0784	Response regulator, receiver
E4184_17915	COG0429	hydrolase of the alpha beta-hydrolase fold
E4184_17920	COG5001	Diguanylate cyclase
E4184_17920	COG3706	GGDEF domain
E4184_17920	COG4251	negative regulation of phosphorylation
E4184_17920	COG2203	Gaf domain
E4184_17925	COG3089	Belongs to the UPF0270 family
E4184_17930	COG3954	Phosphoribulokinase
E4184_17945	COG1765	OsmC-like protein
E4184_17965	COG2205	protein histidine kinase activity
E4184_17970	COG2814	Major facilitator Superfamily
E4184_17995	COG0748	coenzyme F420 binding
E4184_18000	COG3721	Heme iron utilization protein
E4184_18010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4184_18035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4184_18045	COG0463	Glycosyl transferase, family 2
E4184_18050	COG0741	lytic transglycosylase activity
E4184_18055	COG0488	(ABC) transporter
E4184_18065	COG2252	PERMEase
E4184_18070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4184_18075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4184_18080	COG3178	'Phosphotransferase
E4184_18085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4184_18095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4184_18100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4184_18105	COG2967	ApaG domain
E4184_18110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4184_18120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4184_18125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4184_18135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4184_18140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4184_18145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4184_18150	COG0142	geranyltranstransferase activity
E4184_18155	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4184_18160	COG0330	HflC and HflK could
E4184_18165	COG0330	HflC and HflK could
E4184_18170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4184_18175	COG1923	regulation of RNA biosynthetic process
E4184_18180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4184_18185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4184_18195	COG0802	atpase or kinase
E4184_18200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4184_18200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4184_18220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4184_18225	COG2011	ABC-type metal ion transport system permease component
E4184_18230	COG1464	Belongs to the NlpA lipoprotein family
E4184_18240	COG0840	transmembrane signaling receptor activity
E4184_18260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4184_18265	COG5002	protein histidine kinase activity
E4184_18265	COG2198	Histidine kinase
E4184_18265	COG0784	Response regulator, receiver
E4184_18300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4184_18305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4184_18315	COG2716	regulation of RNA biosynthetic process
E4184_18320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4184_18325	COG3013	Belongs to the UPF0304 family
E4184_18335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4184_18340	COG0857	belongs to the CobB CobQ family
E4184_18340	COG0280	phosphate acetyltransferase
E4184_18345	COG0440	acetolactate synthase activity
E4184_18350	COG0028	Belongs to the TPP enzyme family
E4184_18360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4184_18365	COG0671	phosphoesterase, PA-phosphatase related
E4184_18375	COG3385	transposase activity
E4184_18385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4184_18390	COG0473	3-isopropylmalate dehydrogenase activity
E4184_18395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4184_18400	COG0066	3-isopropylmalate dehydratase activity
E4184_18425	COG1178	ABC-type Fe3 transport system permease component
E4184_18430	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4184_18435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4184_18475	COG0316	Belongs to the HesB IscA family
E4184_18485	COG0038	chloride channel
E4184_18490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4184_18505	COG0671	phosphoesterase, PA-phosphatase related
E4184_18515	COG0583	DNA-binding transcription factor activity
E4184_18520	COG2076	Multidrug Resistance protein
E4184_18530	COG0346	lactoylglutathione lyase activity
E4184_18535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4184_18550	COG1489	DNA binding
E4184_18555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4184_18560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4184_18565	COG0617	tRNA 3'-terminal CCA addition
E4184_18575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4184_18580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4184_18590	COG0842	Transport permease protein
E4184_18595	COG1131	(ABC) transporter
E4184_18610	COG0163	prenyltransferase activity
E4184_18615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4184_18620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4184_18635	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4184_18650	COG1136	(ABC) transporter
E4184_18680	COG3039	Transposase
E4184_18690	COG0529	Catalyzes the synthesis of activated sulfate
E4184_18695	COG0471	metal ion transport
E4184_18695	COG3273	potassium ion transport
E4184_18700	COG2895	sulfate adenylyltransferase (ATP) activity
E4184_18705	COG0175	sulfate reduction
E4184_18710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4184_18710	COG1648	precorrin-2 dehydrogenase activity
E4184_18715	COG0330	HflC and HflK could
E4184_18720	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4184_18730	COG0673	inositol 2-dehydrogenase activity
E4184_18740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4184_18745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4184_18750	COG3036	rescue of stalled ribosome
E4184_18765	COG0138	bifunctional purine biosynthesis protein purh
E4184_18770	COG0151	Belongs to the GarS family
E4184_18800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4184_18810	COG1610	YqeY-like protein
E4184_18815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4184_18820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4184_18830	COG4942	peptidase
E4184_18830	COG1388	LysM domain
E4184_18835	COG1238	metal cluster binding
E4184_18840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4184_18845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4184_18850	COG0585	pseudouridine synthase activity
E4184_18860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4184_18865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4184_18870	COG0148	phosphopyruvate hydratase activity
E4184_18875	COG0504	CTP synthase activity
E4184_18880	COG3956	TIGRFAM MazG family protein
E4184_18885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4184_18890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4184_18900	COG4807	Protein conserved in bacteria
E4184_18905	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4184_18910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4184_18915	COG1381	Involved in DNA repair and RecF pathway recombination
E4184_18925	COG0571	ribonuclease III activity
E4184_18930	COG0681	Belongs to the peptidase S26 family
E4184_18935	COG0481	GTPase activity
E4184_18945	COG3026	antisigma factor binding
E4184_18955	COG1595	DNA-templated transcription, initiation
E4184_18960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4184_18980	COG0583	DNA-binding transcription factor activity
E4184_19010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4184_19015	COG0191	fructose-bisphosphate aldolase activity
E4184_19020	COG0126	phosphoglycerate kinase activity
E4184_19025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4184_19030	COG1940	carbohydrate kinase activity
E4184_19035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4184_19040	COG2816	NAD+ diphosphatase activity
E4184_19045	COG4991	sh3 domain protein
E4184_19050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4184_19065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4184_19070	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_19080	COG1505	serine-type exopeptidase activity
E4184_19085	COG3174	membrane
E4184_19090	COG0110	maltose O-acetyltransferase activity
E4184_19100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_19100	COG1263	PTS System
E4184_19105	COG1653	transport
E4184_19110	COG0642	Histidine kinase
E4184_19115	COG0745	RESPONSE REGULATOR receiver
E4184_19135	COG1942	4-Oxalocrotonate Tautomerase
E4184_19145	COG0583	DNA-binding transcription factor activity
E4184_19150	COG0165	Argininosuccinate lyase
E4184_19160	COG0137	argininosuccinate synthase activity
E4184_19170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4184_19175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4184_19185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4184_19195	COG5002	protein histidine kinase activity
E4184_19195	COG3447	MASE1 domain protein
E4184_19195	COG5001	Diguanylate cyclase
E4184_19230	COG0583	DNA-binding transcription factor activity
E4184_19235	COG1380	Effector of murein hydrolase LrgA
E4184_19240	COG1346	cytolysis
E4184_19245	COG0460	homoserine dehydrogenase
E4184_19245	COG0527	aspartate kinase activity
E4184_19250	COG0626	cystathionine gamma-synthase activity
E4184_19265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4184_19270	COG0814	amino acid
E4184_19275	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4184_19280	COG0494	nUDIX hydrolase
E4184_19285	COG1011	Hydrolase
E4184_19290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4184_19305	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4184_19315	COG3156	type II secretion system protein K
E4184_19320	COG4795	General secretion pathway protein
E4184_19325	COG2165	general secretion pathway protein
E4184_19335	COG2165	general secretion pathway protein
E4184_19340	COG1459	type II secretion system
E4184_19345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4184_19350	COG1450	Type ii and iii secretion system protein
E4184_19355	COG3031	protein transport across the cell outer membrane
E4184_19365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4184_19370	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4184_19390	COG3133	Outer membrane lipoprotein
E4184_19395	COG3025	triphosphatase activity
E4184_19400	COG1392	Phosphate transport regulator
E4184_19405	COG0306	phosphate transporter
E4184_19410	COG0617	tRNA 3'-terminal CCA addition
E4184_19415	COG3267	Type II secretory pathway component ExeA
E4184_19415	COG3409	Peptidoglycan-binding domain 1 protein
E4184_19425	COG1194	a g-specific adenine glycosylase
E4184_19430	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4184_19445	COG3240	lipase activity
E4184_19455	COG3009	Protein conserved in bacteria
E4184_19460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4184_19460	COG3008	intermembrane lipid transfer
E4184_19465	COG2995	paraquat-inducible protein a
E4184_19475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_19480	COG2203	Gaf domain
E4184_19480	COG3706	GGDEF domain
E4184_19480	COG5001	Diguanylate cyclase
E4184_19480	COG4251	negative regulation of phosphorylation
E4184_19485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4184_19490	COG2813	Specifically methylates the guanine in position
E4184_19495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4184_19500	COG0297	glycogen (starch) synthase activity
E4184_19530	COG1757	Na H antiporter
E4184_19535	COG0583	DNA-binding transcription factor activity
E4184_19540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4184_19545	COG3842	ATPase activity
E4184_19550	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4184_19555	COG1177	transmembrane transport
E4184_19560	COG1012	belongs to the aldehyde dehydrogenase family
E4184_19565	COG0109	protoheme IX farnesyltransferase activity
E4184_19570	COG1612	heme a metabolic process
E4184_19595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4184_19605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4184_19610	COG1444	tRNA N-acetyltransferase activity
E4184_19630	COG1803	Methylglyoxal synthase
E4184_19645	COG0252	asparaginase activity
E4184_19655	COG1609	Transcriptional regulator
E4184_19665	COG1940	carbohydrate kinase activity
E4184_19670	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4184_19675	COG2723	6-phospho-beta-galactosidase activity
E4184_19680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4184_19680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4184_19685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4184_19690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4184_19700	COG1609	Transcriptional regulator
E4184_19705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4184_19705	COG1263	PTS System
E4184_19710	COG0366	Alpha amylase catalytic
E4184_19715	COG0110	maltose O-acetyltransferase activity
E4184_19720	COG1522	sequence-specific DNA binding
E4184_19770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4184_19775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4184_19790	COG0477	Major facilitator Superfamily
E4184_19795	COG0523	cobalamin synthesis protein
E4184_19805	COG1280	lysine exporter protein (LysE YggA)
E4184_19815	COG0583	DNA-binding transcription factor activity
E4184_19820	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_19825	COG2200	EAL domain
E4184_19830	COG2200	EAL domain
E4184_19835	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4184_19840	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4184_19845	COG0840	transmembrane signaling receptor activity
E4184_19850	COG0840	transmembrane signaling receptor activity
E4184_19855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4184_19860	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4184_19865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4184_19870	COG2186	Transcriptional regulator
E4184_19900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4184_19905	COG1459	type II secretion system
E4184_19920	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4184_19925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4184_19930	COG0494	nUDIX hydrolase
E4184_19935	COG0653	protein targeting
E4184_19945	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4184_19950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4184_19955	COG0849	cell division
E4184_19960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4184_19965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4184_19970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4184_19975	COG0772	Belongs to the SEDS family
E4184_19980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4184_19985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4184_19990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4184_19995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4184_20000	COG0768	penicillin binding
E4184_20005	COG3116	cell division
E4184_20010	COG0275	rRNA processing
E4184_20015	COG2001	Belongs to the MraZ family
E4184_20025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4184_20030	COG3107	peptidoglycan biosynthetic process
E4184_20035	COG0792	nuclease activity
E4184_20040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4184_20045	COG2823	Periplasmic or secreted lipoprotein
E4184_20050	COG2969	positive regulation of protein catabolic process
E4184_20055	COG0625	glutathione transferase activity
E4184_20060	COG2857	Cytochrome c1
E4184_20065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4184_20070	COG0723	plastoquinol--plastocyanin reductase activity
E4184_20075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4184_20080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4184_20085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4184_20095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4184_20100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4184_20130	COG3964	amidohydrolase
E4184_20145	COG3711	transcriptional antiterminator
E4184_20145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_20150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_20155	COG1660	Displays ATPase and GTPase activities
E4184_20160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4184_20175	COG1137	ATPase activity
E4184_20180	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4184_20185	COG3117	lipopolysaccharide transmembrane transporter activity
E4184_20190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4184_20195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4184_20195	COG0517	IMP dehydrogenase activity
E4184_20200	COG1127	ABC transporter
E4184_20205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4184_20210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4184_20215	COG2854	intermembrane phospholipid transfer
E4184_20225	COG5007	Belongs to the BolA IbaG family
E4184_20230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4184_20240	COG0312	modulator of DNA gyrase
E4184_20245	COG3028	Belongs to the UPF0307 family
E4184_20255	COG2926	Belongs to the UPF0265 family
E4184_20285	COG1396	sequence-specific DNA binding
E4184_20290	COG3135	benzoate transporter
E4184_20320	COG3047	cAMP biosynthetic process
E4184_20325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4184_20340	COG1494	fructose-1,6-bisphosphatase
E4184_20380	COG3932	Exopolysaccharide synthesis, ExoD
E4184_20385	COG2199	diguanylate cyclase activity
E4184_20385	COG2203	Gaf domain
E4184_20405	COG1943	Transposase
E4184_20410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4184_20415	COG2022	thiamine diphosphate biosynthetic process
E4184_20425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4184_20430	COG0352	thiamine-phosphate diphosphorylase activity
E4184_20435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4184_20475	COG0745	RESPONSE REGULATOR receiver
E4184_20485	COG0189	ligase activity
E4184_20515	COG0582	viral genome integration into host DNA
E4184_20555	COG3171	Protein conserved in bacteria
E4184_20575	COG1196	nuclear chromosome segregation
E4184_20595	COG2321	neutral zinc metallopeptidase
E4184_20605	COG0477	Major facilitator Superfamily
E4184_20620	COG0312	modulator of DNA gyrase
E4184_20625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4184_20630	COG3164	Protein of unknown function
E4184_20635	COG1530	ribonuclease E activity
E4184_20640	COG0424	maF-like protein
E4184_20645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4184_20650	COG1792	Involved in formation and maintenance of cell shape
E4184_20655	COG1077	Cell shape determining protein MreB Mrl
E4184_20700	COG1459	type II secretion system
E4184_20755	COG2200	EAL domain
E4184_20760	COG0387	Pfam Sodium calcium exchanger
E4184_20765	COG2986	histidine ammonia-lyase
E4184_20770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4184_20775	COG0010	Belongs to the arginase family
E4184_20780	COG1228	amidohydrolase
E4184_20785	COG2188	Transcriptional regulator
E4184_20790	COG0288	reversible hydration of carbon dioxide
E4184_20800	COG2177	Part of the ABC transporter FtsEX involved in
E4184_20805	COG2884	Cell division ATP-binding protein ftsE
E4184_20810	COG0552	protein localization to endoplasmic reticulum
E4184_20815	COG0742	ribosomal rna small subunit methyltransferase
E4184_20845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4184_20850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4184_20860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4184_20870	COG2095	MarC family integral membrane protein
E4184_20880	COG1301	dicarboxylic acid transport
E4184_20905	COG3714	YhhN family
E4184_20925	COG1770	oligopeptidase
E4184_20940	COG4221	oxidoreductase activity
E4184_20945	COG0583	DNA-binding transcription factor activity
E4184_20950	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4184_20970	COG4584	PFAM Integrase catalytic
E4184_20975	COG1484	DNA-dependent DNA replication
E4184_21020	COG0203	ribosomal protein L17
E4184_21025	COG0202	RNA polymerase activity
E4184_21030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4184_21035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4184_21040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4184_21045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4184_21050	COG0201	protein transport
E4184_21055	COG0200	Binds to the 23S rRNA
E4184_21060	COG1841	ribosomal large subunit assembly
E4184_21065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4184_21070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4184_21075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4184_21080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4184_21085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4184_21090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4184_21095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4184_21100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4184_21105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4184_21110	COG0255	Belongs to the universal ribosomal protein uL29 family
E4184_21115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4184_21120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4184_21125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4184_21130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4184_21135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4184_21140	COG0089	rRNA binding
E4184_21145	COG0088	Forms part of the polypeptide exit tunnel
E4184_21150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4184_21155	COG0051	transcription antitermination factor activity, RNA binding
E4184_21165	COG2205	protein histidine kinase activity
E4184_21170	COG0745	RESPONSE REGULATOR receiver
E4184_21180	COG2183	response to ionizing radiation
E4184_21200	COG0596	Alpha beta hydrolase
E4184_21205	COG1040	competence protein
E4184_21210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4184_21210	COG0316	Belongs to the HesB IscA family
E4184_21215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4184_21220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4184_21225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4184_21230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4184_21235	COG4942	peptidase
E4184_21245	COG1609	Transcriptional regulator
E4184_21260	COG0800	Aldolase
E4184_21265	COG0129	dihydroxy-acid dehydratase activity
E4184_21270	COG3265	gluconokinase activity
E4184_21275	COG2610	gluconate transmembrane transporter activity
E4184_21280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4184_21285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4184_21295	COG0456	acetyltransferase
E4184_21305	COG1490	D-aminoacyl-tRNA deacylase activity
E4184_21310	COG1295	ribonuclease BN
E4184_21315	COG1295	ribonuclease BN
E4184_21325	COG0174	glutamine synthetase
E4184_21335	COG3852	Histidine kinase
E4184_21345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4184_21350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4184_21360	COG3078	GTPase activator activity
E4184_21370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4184_21375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4184_21380	COG0408	coproporphyrinogen oxidase activity
E4184_21385	COG0009	L-threonylcarbamoyladenylate synthase
E4184_21390	COG0551	DNA topoisomerase type I activity
E4184_21395	COG2922	Belongs to the Smg family
E4184_21400	COG0758	DNA mediated transformation
E4184_21410	COG0242	peptide deformylase activity
E4184_21415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4184_21420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4184_21420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4184_21425	COG0569	domain protein
E4184_21430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4184_21435	COG1322	Protein conserved in bacteria
E4184_21455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4184_21465	COG0519	Catalyzes the synthesis of GMP from XMP
E4184_21465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4184_21480	COG1396	sequence-specific DNA binding
E4184_21485	COG1012	belongs to the aldehyde dehydrogenase family
E4184_21495	COG2962	Rard protein
E4184_21505	COG1280	lysine exporter protein (LysE YggA)
E4184_21510	COG2391	methyltransferase activity
E4184_21515	COG1280	lysine exporter protein (LysE YggA)
E4184_21520	COG0583	DNA-binding transcription factor activity
E4184_21555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4184_21580	COG2823	Periplasmic or secreted lipoprotein
E4184_21595	COG0583	DNA-binding transcription factor activity
E4184_21600	COG1943	Transposase
E4184_21620	COG5433	transposase activity
E4184_21625	COG3385	transposase activity
E4184_21635	COG0210	DNA helicase
E4184_21670	COG0583	DNA-binding transcription factor activity
E4184_21695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4184_21705	COG0583	DNA-binding transcription factor activity
E4184_21735	COG0385	Bile acid
E4184_21740	COG0531	amino acid
E4184_21745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4184_21750	COG0531	amino acid
E4184_21755	COG2731	YhcH YjgK YiaL family protein
E4184_21760	COG3250	beta-galactosidase activity
E4184_21765	COG1609	Transcriptional regulator
E4184_21805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4184_21810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4184_21810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4184_21815	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4184_21820	COG3074	FtsZ-dependent cytokinesis
E4184_21830	COG1045	serine acetyltransferase
E4184_21840	COG0745	RESPONSE REGULATOR receiver
E4184_21845	COG2205	protein histidine kinase activity
E4184_21850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4184_21855	COG0534	Mate efflux family protein
E4184_21870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4184_21875	COG2937	Belongs to the GPAT DAPAT family
E4184_21885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4184_21890	COG3161	chorismate lyase activity
E4184_21895	COG1580	Controls the rotational direction of flagella during chemotaxis
E4184_21910	COG0604	alcohol dehydrogenase
E4184_21915	COG1609	Transcriptional regulator
E4184_21965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4184_21980	COG1063	alcohol dehydrogenase
E4184_21995	COG0210	DNA helicase
E4184_22000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4184_22005	COG2166	iron-sulfur cluster assembly
E4184_22010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4184_22040	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4184_22045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4184_22050	COG1739	Uncharacterized protein family UPF0029
E4184_22055	COG0006	proline dipeptidase activity
E4184_22060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4184_22065	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4184_22065	COG1024	Enoyl-CoA hydratase
E4184_22070	COG0183	Belongs to the thiolase family
E4184_22075	COG0745	RESPONSE REGULATOR receiver
E4184_22100	COG0425	Belongs to the sulfur carrier protein TusA family
E4184_22105	COG0251	oxidation-reduction process
E4184_22110	COG2885	chlorophyll binding
E4184_22135	COG2818	Glycosylase
E4184_22140	COG0752	glycyl-tRNA synthetase alpha subunit
E4184_22145	COG0751	glycine-tRNA ligase activity
E4184_22185	COG0640	Transcriptional regulator
E4184_22195	COG0814	amino acid
E4184_22200	COG0814	amino acid
E4184_22205	COG3033	Beta-eliminating lyase
E4184_22215	COG0348	domain, Protein
E4184_22225	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4184_22230	COG1773	rubredoxin
E4184_22230	COG0426	domain, Protein
E4184_22235	COG3604	Transcriptional regulator
E4184_22245	COG1609	Transcriptional regulator
E4184_22285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4184_22300	COG2960	long-chain fatty acid transporting porin activity
E4184_22310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4184_22325	COG3118	belongs to the thioredoxin family
E4184_22330	COG0513	Belongs to the DEAD box helicase family
E4184_22335	COG0248	Ppx GppA phosphatase
E4184_22345	COG0742	ribosomal rna small subunit methyltransferase
E4184_22365	COG0084	hydrolase, TatD family'
E4184_22370	COG0805	protein transport
E4184_22375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4184_22380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4184_22385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4184_22390	COG3165	ubiquinone biosynthetic process from chorismate
E4184_22395	COG2226	methyltransferase
E4184_22400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4184_22405	COG0402	S-adenosylhomocysteine deaminase activity
E4184_22445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4184_22450	COG0848	biopolymer transport protein
E4184_22455	COG0811	peptide transport
E4184_22460	COG0811	peptide transport
E4184_22470	COG2771	luxR family
E4184_22485	COG1349	DNA-binding transcription factor activity
E4184_22495	COG1028	Short-chain dehydrogenase reductase Sdr
E4184_22530	COG0166	Belongs to the GPI family
E4184_22535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4184_22625	COG1349	DNA-binding transcription factor activity
E4184_22630	COG0745	RESPONSE REGULATOR receiver
E4184_22635	COG2205	protein histidine kinase activity
E4184_22645	COG4452	Inner membrane protein CreD
E4184_22650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4184_22655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4184_22660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4184_22665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4184_22670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4184_22675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4184_22680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4184_22690	COG0356	it plays a direct role in the translocation of protons across the membrane
E4184_22700	COG1475	DNA binding
E4184_22705	COG1192	Involved in chromosome partitioning
E4184_22710	COG0357	Ribosomal RNA small subunit methyltransferase G
E4184_22715	COG0445	tRNA wobble uridine modification
E4184_22720	COG0716	FMN binding
E4184_22725	COG4774	siderophore transport
E4184_22730	COG4615	Cyclic peptide transporter
E4184_22735	COG1120	ATPase activity
E4184_22740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4184_22750	COG3550	peptidyl-serine autophosphorylation
E4184_22845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4184_22890	COG3344	reverse transcriptase
E4184_22895	COG3385	transposase activity
E4184_22935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4184_22945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4184_22950	COG0732	type I restriction modification DNA specificity domain
E4184_22980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4184_23000	COG4974	Belongs to the 'phage' integrase family
E4184_23005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4184_23010	COG0706	membrane insertase activity
E4184_23015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4184_23020	COG0594	ribonuclease P activity
E4184_23025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4184_23055	COG0640	Transcriptional regulator