locus-tag	class	description
E4186_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4186_00010	COG0592	DNA-directed DNA polymerase activity
E4186_00020	COG0187	DNA topoisomerase II activity
E4186_00030	COG2378	regulation of single-species biofilm formation
E4186_00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4186_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
E4186_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
E4186_00055	COG3977	Valine--pyruvate aminotransferase
E4186_00070	COG2814	Major facilitator Superfamily
E4186_00075	COG0745	RESPONSE REGULATOR receiver
E4186_00080	COG2205	protein histidine kinase activity
E4186_00105	COG1733	regulation of RNA biosynthetic process
E4186_00110	COG2267	carboxylic ester hydrolase activity
E4186_00115	COG0604	alcohol dehydrogenase
E4186_00120	COG0300	oxidoreductase activity
E4186_00125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4186_00130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_00130	COG4191	Histidine kinase
E4186_00135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_00145	COG1309	transcriptional regulator
E4186_00175	COG0561	phosphatase activity
E4186_00180	COG2267	carboxylic ester hydrolase activity
E4186_00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4186_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4186_00195	COG1758	RNA polymerase activity
E4186_00210	COG0859	PFAM glycosyl transferase family 9
E4186_00215	COG3642	lipopolysaccharide core region biosynthetic process
E4186_00255	COG0589	response to stress
E4186_00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4186_00265	COG3706	GGDEF domain
E4186_00270	COG1528	Iron-storage protein
E4186_00275	COG2081	HI0933 family
E4186_00280	COG2223	nitrite transmembrane transporter activity
E4186_00290	COG3275	phosphorelay sensor kinase activity
E4186_00295	COG3279	Response regulator of the LytR AlgR family
E4186_00300	COG2223	nitrite transmembrane transporter activity
E4186_00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4186_00315	COG4206	TonB-dependent receptor
E4186_00320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4186_00355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4186_00360	COG2166	iron-sulfur cluster assembly
E4186_00365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4186_00370	COG0210	DNA helicase
E4186_00385	COG1063	alcohol dehydrogenase
E4186_00400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4186_00405	COG0438	transferase activity, transferring glycosyl groups
E4186_00410	COG3307	-O-antigen
E4186_00430	COG0604	alcohol dehydrogenase
E4186_00445	COG1580	Controls the rotational direction of flagella during chemotaxis
E4186_00450	COG3161	chorismate lyase activity
E4186_00455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4186_00460	COG2937	Belongs to the GPAT DAPAT family
E4186_00465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4186_00480	COG0534	Mate efflux family protein
E4186_00485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4186_00490	COG2205	protein histidine kinase activity
E4186_00495	COG0745	RESPONSE REGULATOR receiver
E4186_00505	COG1045	serine acetyltransferase
E4186_00515	COG3074	FtsZ-dependent cytokinesis
E4186_00520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4186_00530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4186_00530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4186_00535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4186_00575	COG1609	Transcriptional regulator
E4186_00580	COG3250	beta-galactosidase activity
E4186_00585	COG2731	YhcH YjgK YiaL family protein
E4186_00590	COG0531	amino acid
E4186_00595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4186_00600	COG0531	amino acid
E4186_00605	COG0385	Bile acid
E4186_00610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4186_00635	COG0583	DNA-binding transcription factor activity
E4186_00680	COG0210	DNA helicase
E4186_00700	COG5433	transposase activity
E4186_00720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4186_00755	COG2391	methyltransferase activity
E4186_00760	COG1280	lysine exporter protein (LysE YggA)
E4186_00770	COG2962	Rard protein
E4186_00780	COG1012	belongs to the aldehyde dehydrogenase family
E4186_00785	COG1396	sequence-specific DNA binding
E4186_00800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4186_00800	COG0519	Catalyzes the synthesis of GMP from XMP
E4186_00810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4186_00830	COG1322	Protein conserved in bacteria
E4186_00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4186_00840	COG0569	domain protein
E4186_00845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4186_00845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4186_00850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4186_00855	COG0242	peptide deformylase activity
E4186_00865	COG0758	DNA mediated transformation
E4186_00870	COG2922	Belongs to the Smg family
E4186_00875	COG0551	DNA topoisomerase type I activity
E4186_00880	COG0009	L-threonylcarbamoyladenylate synthase
E4186_00885	COG0408	coproporphyrinogen oxidase activity
E4186_00890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4186_00895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4186_00905	COG3078	GTPase activator activity
E4186_00915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4186_00920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4186_00930	COG3852	Histidine kinase
E4186_00940	COG0174	glutamine synthetase
E4186_00950	COG1295	ribonuclease BN
E4186_00955	COG1490	D-aminoacyl-tRNA deacylase activity
E4186_00965	COG0456	acetyltransferase
E4186_00975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4186_00985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4186_00990	COG2610	gluconate transmembrane transporter activity
E4186_00995	COG3265	gluconokinase activity
E4186_01000	COG0129	dihydroxy-acid dehydratase activity
E4186_01005	COG0800	Aldolase
E4186_01025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4186_01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4186_01035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4186_01040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4186_01045	COG0316	Belongs to the HesB IscA family
E4186_01045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4186_01050	COG1040	competence protein
E4186_01055	COG0596	Alpha beta hydrolase
E4186_01070	COG2183	response to ionizing radiation
E4186_01075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4186_01080	COG0745	RESPONSE REGULATOR receiver
E4186_01085	COG2205	protein histidine kinase activity
E4186_01095	COG0051	transcription antitermination factor activity, RNA binding
E4186_01100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4186_01105	COG0088	Forms part of the polypeptide exit tunnel
E4186_01110	COG0089	rRNA binding
E4186_01115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4186_01120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4186_01125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4186_01130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4186_01135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4186_01140	COG0255	Belongs to the universal ribosomal protein uL29 family
E4186_01145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4186_01150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4186_01155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4186_01160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4186_01165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4186_01170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4186_01175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4186_01180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4186_01185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4186_01190	COG1841	ribosomal large subunit assembly
E4186_01195	COG0200	Binds to the 23S rRNA
E4186_01200	COG0201	protein transport
E4186_01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4186_01210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4186_01215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4186_01220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4186_01225	COG0202	RNA polymerase activity
E4186_01230	COG0203	ribosomal protein L17
E4186_01280	COG5433	transposase activity
E4186_01305	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4186_01320	COG1770	oligopeptidase
E4186_01340	COG3714	YhhN family
E4186_01365	COG1301	dicarboxylic acid transport
E4186_01375	COG2095	MarC family integral membrane protein
E4186_01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4186_01395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4186_01400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4186_01430	COG0742	ribosomal rna small subunit methyltransferase
E4186_01435	COG0552	protein localization to endoplasmic reticulum
E4186_01440	COG2884	Cell division ATP-binding protein ftsE
E4186_01445	COG2177	Part of the ABC transporter FtsEX involved in
E4186_01455	COG0288	reversible hydration of carbon dioxide
E4186_01460	COG2188	Transcriptional regulator
E4186_01465	COG1228	amidohydrolase
E4186_01470	COG0010	Belongs to the arginase family
E4186_01475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4186_01480	COG2986	histidine ammonia-lyase
E4186_01485	COG0387	Pfam Sodium calcium exchanger
E4186_01490	COG2200	EAL domain
E4186_01525	COG5433	transposase activity
E4186_01545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4186_01550	COG1459	type II secretion system
E4186_01595	COG1077	Cell shape determining protein MreB Mrl
E4186_01600	COG1792	Involved in formation and maintenance of cell shape
E4186_01605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4186_01610	COG0424	maF-like protein
E4186_01615	COG1530	ribonuclease E activity
E4186_01620	COG3164	Protein of unknown function
E4186_01625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4186_01630	COG0312	modulator of DNA gyrase
E4186_01645	COG0477	Major facilitator Superfamily
E4186_01655	COG2321	neutral zinc metallopeptidase
E4186_01685	COG0189	ligase activity
E4186_01690	COG0642	Histidine kinase
E4186_01695	COG0745	RESPONSE REGULATOR receiver
E4186_01715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4186_01720	COG0352	thiamine-phosphate diphosphorylase activity
E4186_01725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4186_01735	COG2022	thiamine diphosphate biosynthetic process
E4186_01740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4186_01745	COG1943	Transposase
E4186_01755	COG0110	maltose O-acetyltransferase activity
E4186_01765	COG3706	GGDEF domain
E4186_01770	COG3932	Exopolysaccharide synthesis, ExoD
E4186_01790	COG1733	regulation of RNA biosynthetic process
E4186_01795	COG0456	acetyltransferase
E4186_01815	COG1247	-acetyltransferase
E4186_01825	COG1494	fructose-1,6-bisphosphatase
E4186_01835	COG3071	HemY protein
E4186_01840	COG2959	enzyme of heme biosynthesis
E4186_01850	COG0181	hydroxymethylbilane synthase activity
E4186_01855	COG3072	Adenylate cyclase
E4186_01860	COG0400	carboxylic ester hydrolase activity
E4186_01865	COG1965	Belongs to the frataxin family
E4186_01875	COG0019	diaminopimelate decarboxylase activity
E4186_01880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4186_01895	COG1011	Hydrolase
E4186_01905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4186_01910	COG0561	phosphatase activity
E4186_01920	COG1988	membrane-bound metal-dependent
E4186_01925	COG1546	Belongs to the CinA family
E4186_01925	COG1058	Belongs to the CinA family
E4186_01935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4186_01945	COG1522	sequence-specific DNA binding
E4186_01955	COG3135	benzoate transporter
E4186_01960	COG1396	sequence-specific DNA binding
E4186_01995	COG2926	Belongs to the UPF0265 family
E4186_02005	COG3028	Belongs to the UPF0307 family
E4186_02010	COG0312	modulator of DNA gyrase
E4186_02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4186_02020	COG5007	Belongs to the BolA IbaG family
E4186_02030	COG2854	intermembrane phospholipid transfer
E4186_02035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4186_02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4186_02045	COG1127	ABC transporter
E4186_02050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4186_02050	COG0517	IMP dehydrogenase activity
E4186_02055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4186_02060	COG3117	lipopolysaccharide transmembrane transporter activity
E4186_02065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4186_02070	COG1137	ATPase activity
E4186_02085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_02090	COG1660	Displays ATPase and GTPase activities
E4186_02095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4186_02110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4186_02120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4186_02125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4186_02130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4186_02135	COG0723	plastoquinol--plastocyanin reductase activity
E4186_02140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4186_02145	COG2857	Cytochrome c1
E4186_02150	COG0625	glutathione transferase activity
E4186_02155	COG2969	positive regulation of protein catabolic process
E4186_02160	COG2823	Periplasmic or secreted lipoprotein
E4186_02165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4186_02170	COG0792	nuclease activity
E4186_02175	COG3107	peptidoglycan biosynthetic process
E4186_02180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4186_02190	COG2001	Belongs to the MraZ family
E4186_02195	COG0275	rRNA processing
E4186_02200	COG3116	cell division
E4186_02205	COG0768	penicillin binding
E4186_02210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4186_02215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4186_02220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4186_02225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4186_02230	COG0772	Belongs to the SEDS family
E4186_02235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4186_02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4186_02245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4186_02250	COG0849	cell division
E4186_02255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4186_02260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4186_02270	COG0653	protein targeting
E4186_02280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4186_02285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4186_02295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4186_02300	COG1459	type II secretion system
E4186_02305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4186_02345	COG2186	Transcriptional regulator
E4186_02350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4186_02355	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4186_02360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4186_02380	COG0840	transmembrane signaling receptor activity
E4186_02385	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4186_02390	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4186_02395	COG2200	EAL domain
E4186_02405	COG1280	lysine exporter protein (LysE YggA)
E4186_02415	COG0523	cobalamin synthesis protein
E4186_02420	COG0477	Major facilitator Superfamily
E4186_02435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4186_02440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4186_02490	COG5006	permease, DMT superfamily
E4186_02495	COG1522	sequence-specific DNA binding
E4186_02500	COG0110	maltose O-acetyltransferase activity
E4186_02505	COG0366	Alpha amylase catalytic
E4186_02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4186_02510	COG1263	PTS System
E4186_02525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4186_02530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4186_02535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4186_02535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4186_02540	COG2723	6-phospho-beta-galactosidase activity
E4186_02545	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4186_02550	COG1940	carbohydrate kinase activity
E4186_02560	COG1609	Transcriptional regulator
E4186_02570	COG0252	asparaginase activity
E4186_02585	COG1803	Methylglyoxal synthase
E4186_02610	COG1444	tRNA N-acetyltransferase activity
E4186_02615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4186_02620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4186_02625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4186_02650	COG1612	heme a metabolic process
E4186_02655	COG0109	protoheme IX farnesyltransferase activity
E4186_02660	COG1012	belongs to the aldehyde dehydrogenase family
E4186_02665	COG1177	transmembrane transport
E4186_02670	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4186_02675	COG3842	ATPase activity
E4186_02680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4186_02685	COG0583	DNA-binding transcription factor activity
E4186_02690	COG1757	Na H antiporter
E4186_02730	COG0297	glycogen (starch) synthase activity
E4186_02735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4186_02740	COG2813	Specifically methylates the guanine in position
E4186_02745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4186_02750	COG4251	negative regulation of phosphorylation
E4186_02750	COG5001	Diguanylate cyclase
E4186_02750	COG3706	GGDEF domain
E4186_02750	COG2203	Gaf domain
E4186_02755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4186_02765	COG2995	paraquat-inducible protein a
E4186_02770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4186_02770	COG3008	intermembrane lipid transfer
E4186_02775	COG3009	Protein conserved in bacteria
E4186_02785	COG3240	lipase activity
E4186_02800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4186_02805	COG1194	a g-specific adenine glycosylase
E4186_02815	COG3409	Peptidoglycan-binding domain 1 protein
E4186_02815	COG3267	Type II secretory pathway component ExeA
E4186_02820	COG0617	tRNA 3'-terminal CCA addition
E4186_02825	COG0306	phosphate transporter
E4186_02830	COG1392	Phosphate transport regulator
E4186_02840	COG3133	Outer membrane lipoprotein
E4186_02860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4186_02865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4186_02875	COG3031	protein transport across the cell outer membrane
E4186_02885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4186_02890	COG1459	type II secretion system
E4186_02895	COG2165	general secretion pathway protein
E4186_02905	COG2165	general secretion pathway protein
E4186_02910	COG4795	General secretion pathway protein
E4186_02930	COG3156	type II secretion system protein K
E4186_02940	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4186_02955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4186_02960	COG1011	Hydrolase
E4186_02965	COG0494	nUDIX hydrolase
E4186_02970	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4186_02975	COG0814	amino acid
E4186_02980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4186_02995	COG0626	cystathionine gamma-synthase activity
E4186_03000	COG0527	aspartate kinase activity
E4186_03000	COG0460	homoserine dehydrogenase
E4186_03005	COG1346	cytolysis
E4186_03010	COG1380	Effector of murein hydrolase LrgA
E4186_03015	COG0583	DNA-binding transcription factor activity
E4186_03050	COG3447	MASE1 domain protein
E4186_03050	COG5001	Diguanylate cyclase
E4186_03050	COG5002	protein histidine kinase activity
E4186_03055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4186_03065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4186_03070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4186_03080	COG0137	argininosuccinate synthase activity
E4186_03085	COG0165	Argininosuccinate lyase
E4186_03095	COG3039	Transposase
E4186_03110	COG0110	maltose O-acetyltransferase activity
E4186_03115	COG3174	membrane
E4186_03120	COG1505	serine-type exopeptidase activity
E4186_03125	COG2982	Protein involved in outer membrane biogenesis
E4186_03130	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_03140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4186_03155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4186_03160	COG4991	sh3 domain protein
E4186_03170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4186_03175	COG1940	carbohydrate kinase activity
E4186_03180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4186_03185	COG0126	phosphoglycerate kinase activity
E4186_03190	COG0191	fructose-bisphosphate aldolase activity
E4186_03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4186_03245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4186_03250	COG1595	DNA-templated transcription, initiation
E4186_03270	COG0481	GTPase activity
E4186_03275	COG0681	Belongs to the peptidase S26 family
E4186_03280	COG0571	ribonuclease III activity
E4186_03290	COG1381	Involved in DNA repair and RecF pathway recombination
E4186_03295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4186_03300	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4186_03305	COG4807	Protein conserved in bacteria
E4186_03315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4186_03320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4186_03325	COG3956	TIGRFAM MazG family protein
E4186_03330	COG0504	CTP synthase activity
E4186_03335	COG0148	phosphopyruvate hydratase activity
E4186_03340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4186_03345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4186_03355	COG0585	pseudouridine synthase activity
E4186_03360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4186_03365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4186_03370	COG1238	metal cluster binding
E4186_03375	COG1388	LysM domain
E4186_03375	COG4942	peptidase
E4186_03385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4186_03390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4186_03395	COG1610	YqeY-like protein
E4186_03400	COG0358	DNA primase activity
E4186_03405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4186_03435	COG0151	Belongs to the GarS family
E4186_03440	COG0138	bifunctional purine biosynthesis protein purh
E4186_03455	COG3036	rescue of stalled ribosome
E4186_03460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4186_03465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4186_03475	COG0673	inositol 2-dehydrogenase activity
E4186_03485	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4186_03490	COG0330	HflC and HflK could
E4186_03495	COG1648	precorrin-2 dehydrogenase activity
E4186_03495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4186_03500	COG0175	sulfate reduction
E4186_03505	COG2895	sulfate adenylyltransferase (ATP) activity
E4186_03510	COG0471	metal ion transport
E4186_03510	COG3273	potassium ion transport
E4186_03515	COG0529	Catalyzes the synthesis of activated sulfate
E4186_03525	COG3039	Transposase
E4186_03535	COG5433	transposase activity
E4186_03585	COG1136	(ABC) transporter
E4186_03600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4186_03615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4186_03620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4186_03625	COG0163	prenyltransferase activity
E4186_03640	COG1131	(ABC) transporter
E4186_03645	COG0842	Transport permease protein
E4186_03655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4186_03660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4186_03670	COG0617	tRNA 3'-terminal CCA addition
E4186_03675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4186_03680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4186_03685	COG1489	DNA binding
E4186_03690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4186_03695	COG1643	Atp-dependent helicase
E4186_03700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4186_03705	COG0346	lactoylglutathione lyase activity
E4186_03720	COG2076	Multidrug Resistance protein
E4186_03725	COG0583	DNA-binding transcription factor activity
E4186_03735	COG0671	phosphoesterase, PA-phosphatase related
E4186_03750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4186_03755	COG0038	chloride channel
E4186_03765	COG0316	Belongs to the HesB IscA family
E4186_03810	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4186_03820	COG3311	Transcriptional regulator
E4186_03870	COG2003	Belongs to the UPF0758 family
E4186_03950	COG3293	Transposase
E4186_03965	COG4584	PFAM Integrase catalytic
E4186_03970	COG1484	DNA-dependent DNA replication
E4186_03980	COG0732	type I restriction modification DNA specificity domain
E4186_04005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4186_04010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4186_04020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_04050	COG0745	RESPONSE REGULATOR receiver
E4186_04055	COG3104	oligopeptide transport
E4186_04060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4186_04065	COG1555	photosystem II stabilization
E4186_04075	COG2350	Protein conserved in bacteria
E4186_04080	COG2917	probably involved in intracellular septation
E4186_04085	COG0076	glutamate decarboxylase activity
E4186_04095	COG2985	domain, Protein
E4186_04095	COG0569	domain protein
E4186_04105	COG0477	Major facilitator Superfamily
E4186_04110	COG0583	DNA-binding transcription factor activity
E4186_04120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4186_04125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4186_04135	COG2731	YhcH YjgK YiaL family protein
E4186_04145	COG0668	transmembrane transport
E4186_04150	COG1376	ErfK ybiS ycfS ynhG family protein
E4186_04155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4186_04180	COG3039	Transposase
E4186_04210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4186_04220	COG0488	(ABC) transporter
E4186_04225	COG0517	IMP dehydrogenase activity
E4186_04230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4186_04235	COG0835	chemotaxis
E4186_04235	COG0784	Response regulator, receiver
E4186_04240	COG2755	lipolytic protein G-D-S-L family
E4186_04245	COG4181	ATPase activity
E4186_04250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4186_04255	COG1090	epimerase
E4186_04260	COG2200	EAL domain
E4186_04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4186_04270	COG4935	Belongs to the peptidase S8 family
E4186_04270	COG2234	aminopeptidase activity
E4186_04275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4186_04280	COG3171	Protein conserved in bacteria
E4186_04285	COG2066	Belongs to the glutaminase family
E4186_04290	COG2897	thiosulfate sulfurtransferase activity
E4186_04300	COG1132	(ABC) transporter
E4186_04325	COG0583	DNA-binding transcription factor activity
E4186_04335	COG5433	transposase activity
E4186_04360	COG1609	Transcriptional regulator
E4186_04370	COG2017	converts alpha-aldose to the beta-anomer
E4186_04375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4186_04385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4186_04395	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4186_04400	COG3300	MHYT domain
E4186_04400	COG5001	Diguanylate cyclase
E4186_04410	COG2207	Transcriptional regulator
E4186_04415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4186_04430	COG4628	conserved protein (DUF2132)
E4186_04435	COG0688	phosphatidylethanolamine metabolic process
E4186_04445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4186_04485	COG1278	Cold shock
E4186_04495	COG0840	transmembrane signaling receptor activity
E4186_04500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4186_04505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4186_04550	COG0848	biopolymer transport protein
E4186_04555	COG0811	peptide transport
E4186_04560	COG0811	peptide transport
E4186_04570	COG4206	TonB-dependent receptor
E4186_04575	COG4174	ABC transporter (Permease)
E4186_04580	COG4239	(ABC) transporter, permease
E4186_04585	COG0747	negative chemotaxis
E4186_04595	COG4608	Belongs to the ABC transporter superfamily
E4186_04605	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4186_04620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4186_04640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4186_04665	COG0243	molybdopterin cofactor binding
E4186_04680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4186_04680	COG1116	anion transmembrane transporter activity
E4186_04685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4186_04690	COG1116	anion transmembrane transporter activity
E4186_04700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4186_04700	COG2146	nitrite reductase [NAD(P)H] activity
E4186_04705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4186_04710	COG2313	pseudouridylate synthase activity
E4186_04765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4186_04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4186_04820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4186_04830	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_04835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4186_04845	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4186_04850	COG5433	transposase activity
E4186_04875	COG2966	Psort location CytoplasmicMembrane, score
E4186_04880	COG3610	response to peptide
E4186_04890	COG4175	Glycine betaine
E4186_04895	COG4176	ABC-type proline glycine betaine transport system permease component
E4186_04900	COG2113	Glycine betaine
E4186_04905	COG0175	sulfate reduction
E4186_04910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4186_04915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4186_04920	COG0384	phenazine biosynthesis protein PhzF
E4186_04925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4186_04940	COG5001	Diguanylate cyclase
E4186_04945	COG0786	glutamate:sodium symporter activity
E4186_04950	COG0252	asparaginase activity
E4186_04955	COG3139	Protein of unknown function (DUF1315)
E4186_04975	COG0616	signal peptide processing
E4186_04980	COG1902	pentaerythritol trinitrate reductase activity
E4186_04980	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4186_04985	COG0778	Nitroreductase
E4186_04995	COG2264	protein methyltransferase activity
E4186_05000	COG0604	alcohol dehydrogenase
E4186_05005	COG0583	DNA-binding transcription factor activity
E4186_05010	COG2190	(PTS) system
E4186_05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4186_05010	COG1263	PTS System
E4186_05015	COG4145	pantothenate transmembrane transporter activity
E4186_05020	COG3924	membrane
E4186_05025	COG0439	Biotin carboxylase
E4186_05030	COG0511	ligase activity, forming carbon-carbon bonds
E4186_05035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4186_05040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4186_05060	COG3381	protein complex oligomerization
E4186_05070	COG3005	denitrification pathway
E4186_05075	COG0745	RESPONSE REGULATOR receiver
E4186_05085	COG1879	ABC-type sugar transport system periplasmic component
E4186_05090	COG0784	Response regulator, receiver
E4186_05090	COG2198	Histidine kinase
E4186_05090	COG2205	protein histidine kinase activity
E4186_05100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4186_05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4186_05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4186_05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4186_05135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4186_05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4186_05145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4186_05150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4186_05155	COG4172	Belongs to the ABC transporter superfamily
E4186_05175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4186_05180	COG0142	geranyltranstransferase activity
E4186_05185	COG1722	exodeoxyribonuclease VII activity
E4186_05190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4186_05195	COG1360	Flagellar Motor Protein
E4186_05210	COG1534	Rna-binding protein
E4186_05215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4186_05225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4186_05230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4186_05235	COG0149	triose-phosphate isomerase activity
E4186_05240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4186_05255	COG0779	Required for maturation of 30S ribosomal subunits
E4186_05260	COG0195	Participates in both transcription termination and antitermination
E4186_05265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4186_05270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4186_05275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4186_05280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4186_05285	COG1185	polyribonucleotide nucleotidyltransferase activity
E4186_05290	COG2211	Major facilitator Superfamily
E4186_05295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4186_05315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4186_05335	COG0312	modulator of DNA gyrase
E4186_05355	COG4974	Belongs to the 'phage' integrase family
E4186_05365	COG1970	mechanosensitive ion channel activity
E4186_05380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4186_05390	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4186_05400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4186_05410	COG0321	lipoyl(octanoyl) transferase activity
E4186_05415	COG2921	Belongs to the UPF0250 family
E4186_05420	COG1686	Belongs to the peptidase S11 family
E4186_05425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4186_05430	COG2951	lytic endotransglycosylase activity
E4186_05435	COG0772	Belongs to the SEDS family
E4186_05440	COG0768	penicillin binding
E4186_05445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4186_05450	COG0799	negative regulation of ribosome biogenesis
E4186_05455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4186_05470	COG0495	leucyl-tRNA aminoacylation
E4186_05475	COG2888	peptidyl-tyrosine sulfation
E4186_05480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4186_05485	COG4535	Mg2 and Co2 transporter CorC
E4186_05490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4186_05495	COG1702	phosphate starvation-inducible protein PhoH
E4186_05500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4186_05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4186_05510	COG1278	Cold shock
E4186_05515	COG0583	DNA-binding transcription factor activity
E4186_05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4186_05540	COG2199	diguanylate cyclase activity
E4186_05550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4186_05560	COG3647	Membrane
E4186_05565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4186_05575	COG0516	GMP reductase activity
E4186_05585	COG0642	Histidine kinase
E4186_05590	COG0745	RESPONSE REGULATOR receiver
E4186_05600	COG0300	oxidoreductase activity
E4186_05610	COG1022	Amp-dependent synthetase and ligase
E4186_05620	COG4106	trans-aconitate 2-methyltransferase activity
E4186_05625	COG3214	Protein conserved in bacteria
E4186_05635	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4186_05640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4186_05645	COG1053	succinate dehydrogenase
E4186_05655	COG0584	glycerophosphoryl diester phosphodiesterase
E4186_05660	COG3264	Mechanosensitive ion channel
E4186_05660	COG1511	domain protein
E4186_05670	COG0739	heme binding
E4186_05675	COG3121	Chaperone
E4186_05680	COG3188	usher protein
E4186_05685	COG3121	Chaperone
E4186_05700	COG0583	DNA-binding transcription factor activity
E4186_05715	COG0583	DNA-binding transcription factor activity
E4186_05720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4186_05755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4186_05760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4186_05770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4186_05775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4186_05785	COG0180	Tryptophanyl-tRNA synthetase
E4186_05800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4186_05810	COG1012	belongs to the aldehyde dehydrogenase family
E4186_05820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4186_05845	COG0490	domain, Protein
E4186_05845	COG0471	metal ion transport
E4186_05890	COG0012	GTP binding
E4186_05895	COG0193	aminoacyl-tRNA hydrolase activity
E4186_05900	COG0737	Belongs to the 5'-nucleotidase family
E4186_05905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4186_05915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4186_05920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4186_05925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4186_05930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4186_05935	COG2890	protein-(glutamine-N5) methyltransferase activity
E4186_05945	COG2912	Transglutaminase-like superfamily
E4186_05975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4186_05990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4186_05995	COG1115	amino acid carrier protein
E4186_06025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4186_06045	COG0189	ligase activity
E4186_06050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4186_06060	COG3091	SprT-like family
E4186_06070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4186_06105	COG5433	transposase activity
E4186_06115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4186_06120	COG0739	heme binding
E4186_06125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4186_06130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4186_06130	COG3408	Glycogen debranching enzyme
E4186_06140	COG1881	PFAM PEBP family protein
E4186_06150	COG0583	DNA-binding transcription factor activity
E4186_06160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4186_06170	COG0583	DNA-binding transcription factor activity
E4186_06175	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_06180	COG0616	signal peptide processing
E4186_06185	COG3724	N-succinylarginine dihydrolase activity
E4186_06210	COG0840	transmembrane signaling receptor activity
E4186_06220	COG2971	BadF BadG BcrA BcrD
E4186_06230	COG4608	Belongs to the ABC transporter superfamily
E4186_06235	COG0444	Belongs to the ABC transporter superfamily
E4186_06240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4186_06255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4186_06275	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4186_06335	COG1684	flagellar biosynthetic protein fliR
E4186_06350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4186_06375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4186_06380	COG0643	Histidine kinase
E4186_06380	COG0784	Response regulator, receiver
E4186_06380	COG2198	Histidine kinase
E4186_06385	COG2201	protein-glutamate methylesterase activity
E4186_06390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4186_06395	COG1360	Flagellar Motor Protein
E4186_06400	COG1192	Involved in chromosome partitioning
E4186_06410	COG0835	chemotaxis
E4186_06425	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4186_06430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4186_06435	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4186_06440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4186_06445	COG1138	Cytochrome C-type biogenesis protein
E4186_06450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4186_06455	COG3088	subunit of a heme lyase
E4186_06455	COG4235	cytochrome complex assembly
E4186_06475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4186_06480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4186_06480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4186_06505	COG0259	pyridoxamine-phosphate oxidase activity
E4186_06515	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4186_06520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4186_06535	COG0083	homoserine kinase activity
E4186_06540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4186_06545	COG4319	ketosteroid isomerase
E4186_06605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4186_06610	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4186_06615	COG0746	molybdenum cofactor guanylyltransferase activity
E4186_06620	COG0281	malic enzyme
E4186_06640	COG2706	6-phosphogluconolactonase activity
E4186_06650	COG1196	nuclear chromosome segregation
E4186_06650	COG3264	Mechanosensitive ion channel
E4186_06655	COG0469	pyruvate kinase activity
E4186_06660	COG2850	peptidyl-arginine hydroxylation
E4186_06665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4186_06670	COG2915	High frequency lysogenization protein hflD homolog
E4186_06675	COG0482	sulfurtransferase activity
E4186_06695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4186_06715	COG1484	DNA-dependent DNA replication
E4186_06720	COG4584	PFAM Integrase catalytic
E4186_06755	COG3436	PFAM IS66 Orf2 family protein
E4186_06760	COG4372	Transposase
E4186_06765	COG5492	domain, Protein
E4186_06765	COG4932	domain protein
E4186_06780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4186_06795	COG1482	cell wall glycoprotein biosynthetic process
E4186_06800	COG2207	Transcriptional regulator
E4186_06805	COG0538	isocitrate dehydrogenase activity
E4186_06815	COG3048	D-serine ammonia-lyase activity
E4186_06820	COG2610	gluconate transmembrane transporter activity
E4186_06825	COG0583	DNA-binding transcription factor activity
E4186_06830	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4186_06835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4186_06840	COG2375	cellular response to nickel ion
E4186_06850	COG0577	efflux transmembrane transporter activity
E4186_06850	COG1136	(ABC) transporter
E4186_06855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_06865	COG1227	inorganic diphosphatase activity
E4186_06870	COG0497	DNA recombination
E4186_06875	COG3706	GGDEF domain
E4186_06880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4186_06885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4186_06890	COG0443	Heat shock 70 kDa protein
E4186_06895	COG0484	heat shock protein binding
E4186_06925	COG1285	pathogenesis
E4186_06950	COG2391	methyltransferase activity
E4186_06970	COG0095	Lipoate-protein ligase
E4186_06985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_06990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_07000	COG0708	Exodeoxyribonuclease III
E4186_07025	COG0071	Belongs to the small heat shock protein (HSP20) family
E4186_07065	COG0583	DNA-binding transcription factor activity
E4186_07070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4186_07075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4186_07080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4186_07085	COG1845	cytochrome c oxidase, subunit III
E4186_07090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4186_07095	COG0109	protoheme IX farnesyltransferase activity
E4186_07105	COG2814	Major facilitator Superfamily
E4186_07110	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4186_07140	COG0675	Transposase, IS605 OrfB family
E4186_07155	COG3550	peptidyl-serine autophosphorylation
E4186_07160	COG1396	sequence-specific DNA binding
E4186_07165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4186_07175	COG3039	Transposase
E4186_07180	COG0159	tryptophan synthase activity
E4186_07185	COG0133	tryptophan synthase activity
E4186_07190	COG0134	indole-3-glycerol-phosphate synthase activity
E4186_07190	COG0135	phosphoribosylanthranilate isomerase activity
E4186_07195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4186_07200	COG0512	Glutamine amidotransferase of anthranilate synthase
E4186_07200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4186_07205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4186_07220	COG0009	L-threonylcarbamoyladenylate synthase
E4186_07230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4186_07240	COG1946	Acyl-CoA thioesterase
E4186_07255	COG1309	transcriptional regulator
E4186_07260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_07265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_07295	COG4584	PFAM Integrase catalytic
E4186_07300	COG1484	DNA-dependent DNA replication
E4186_07320	COG3657	addiction module killer protein
E4186_07370	COG0328	RNA-DNA hybrid ribonuclease activity
E4186_07395	COG3039	Transposase
E4186_07410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4186_07420	COG1960	acyl-CoA dehydrogenase activity
E4186_07425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_07435	COG0469	pyruvate kinase activity
E4186_07440	COG1737	Transcriptional regulator
E4186_07450	COG2205	protein histidine kinase activity
E4186_07465	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4186_07495	COG1215	transferase activity, transferring glycosyl groups
E4186_07500	COG1215	transferase activity, transferring glycosyl groups
E4186_07515	COG2895	sulfate adenylyltransferase (ATP) activity
E4186_07520	COG3273	potassium ion transport
E4186_07520	COG0471	metal ion transport
E4186_07525	COG0529	Catalyzes the synthesis of activated sulfate
E4186_07540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4186_07555	COG3039	Transposase
E4186_07585	COG1216	Glycosyl transferase, family 2
E4186_07605	COG3039	Transposase
E4186_07630	COG1086	Polysaccharide biosynthesis protein
E4186_07650	COG1596	polysaccharide export
E4186_07655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4186_07660	COG0489	protein tyrosine kinase activity
E4186_07660	COG3206	protein involved in exopolysaccharide biosynthesis
E4186_07665	COG3039	Transposase
E4186_07685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4186_07705	COG3132	Protein of unknown function, DUF480
E4186_07710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4186_07745	COG1278	Cold shock
E4186_07775	COG0697	spore germination
E4186_07795	COG0675	Transposase, IS605 OrfB family
E4186_07805	COG1187	pseudouridine synthase activity
E4186_07815	COG4166	transmembrane transport
E4186_07820	COG0622	Phosphoesterase
E4186_07835	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4186_07840	COG0835	chemotaxis
E4186_07840	COG0784	Response regulator, receiver
E4186_07845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4186_07850	COG1815	bacterial-type flagellum-dependent cell motility
E4186_07880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4186_07885	COG1706	bacterial-type flagellum-dependent cell motility
E4186_07890	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4186_07890	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4186_07925	COG0675	Transposase, IS605 OrfB family
E4186_07940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4186_07945	COG2716	regulation of RNA biosynthetic process
E4186_07965	COG3852	Histidine kinase
E4186_07975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4186_07980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4186_07985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4186_07990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4186_08010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4186_08025	COG0573	inorganic phosphate transmembrane transporter activity
E4186_08030	COG0581	inorganic phosphate transmembrane transporter activity
E4186_08045	COG1253	flavin adenine dinucleotide binding
E4186_08060	COG0531	amino acid
E4186_08070	COG1126	abc transporter atp-binding protein
E4186_08075	COG0765	amino acid transport
E4186_08080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_08090	COG2271	Major facilitator Superfamily
E4186_08100	COG2197	response regulator
E4186_08105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4186_08130	COG1785	Belongs to the alkaline phosphatase family
E4186_08135	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4186_08140	COG0477	Major facilitator Superfamily
E4186_08145	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4186_08155	COG1199	ATP-dependent helicase activity
E4186_08170	COG1448	Aminotransferase
E4186_08175	COG0433	COG0433 Predicted ATPase
E4186_08190	COG0658	competence protein
E4186_08190	COG2333	competence protein COMEC
E4186_08195	COG1132	(ABC) transporter
E4186_08200	COG1663	tetraacyldisaccharide 4'-kinase activity
E4186_08205	COG2835	tetraacyldisaccharide 4'-kinase activity
E4186_08210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4186_08215	COG2197	response regulator
E4186_08220	COG0322	excinuclease ABC activity
E4186_08285	COG0625	glutathione transferase activity
E4186_08290	COG2261	transglycosylase associated protein
E4186_08295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4186_08305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4186_08325	COG3039	Transposase
E4186_08340	COG2203	Gaf domain
E4186_08340	COG2199	diguanylate cyclase activity
E4186_08380	COG2119	membrane
E4186_08385	COG0023	Translation Initiation Factor
E4186_08395	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4186_08430	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4186_08435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4186_08440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4186_08445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4186_08450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4186_08455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4186_08460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4186_08470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4186_08475	COG0505	Belongs to the CarA family
E4186_08480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4186_08485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4186_08515	COG0513	Belongs to the DEAD box helicase family
E4186_08525	COG4104	PAAR repeat-containing protein
E4186_08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_08545	COG0765	amino acid transport
E4186_08550	COG1126	abc transporter atp-binding protein
E4186_08560	COG0493	'glutamate synthase
E4186_08565	COG0070	glutamate synthase
E4186_08565	COG0069	glutamate synthase activity
E4186_08565	COG0067	glutamate synthase
E4186_08570	COG1242	4 iron, 4 sulfur cluster binding
E4186_08615	COG1113	amino acid transport
E4186_08625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4186_08630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4186_08630	COG0574	Belongs to the PEP-utilizing enzyme family
E4186_08635	COG1119	ATPase activity
E4186_08655	COG1464	Belongs to the NlpA lipoprotein family
E4186_08660	COG0671	phosphoesterase, PA-phosphatase related
E4186_08665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4186_08670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4186_08680	COG0101	tRNA pseudouridine synthase activity
E4186_08685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4186_08690	COG0285	dihydrofolate synthase activity
E4186_08695	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4186_08700	COG2920	part of a sulfur-relay system
E4186_08705	COG1289	transmembrane transporter activity
E4186_08710	COG0670	Belongs to the BI1 family
E4186_08735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4186_08745	COG2175	clavaminate synthase activity
E4186_08750	COG3246	L-lysine catabolic process to acetate
E4186_08755	COG2814	Major facilitator Superfamily
E4186_08765	COG2855	membrane
E4186_08790	COG4447	cellulose binding
E4186_08810	COG0318	PFAM AMP-dependent synthetase and ligase
E4186_08815	COG0840	transmembrane signaling receptor activity
E4186_08825	COG3706	GGDEF domain
E4186_08830	COG0564	pseudouridine synthase activity
E4186_08845	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4186_08855	COG0625	glutathione transferase activity
E4186_08865	COG0367	asparagine synthase
E4186_08875	COG0647	UMP catabolic process
E4186_08880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4186_08885	COG1902	pentaerythritol trinitrate reductase activity
E4186_08890	COG1253	flavin adenine dinucleotide binding
E4186_08900	COG0247	lactate metabolic process
E4186_08900	COG0277	FAD linked oxidase domain protein
E4186_08910	COG2050	protein possibly involved in aromatic compounds catabolism
E4186_08915	COG0513	Belongs to the DEAD box helicase family
E4186_08930	COG0583	DNA-binding transcription factor activity
E4186_08935	COG2814	Major facilitator Superfamily
E4186_08940	COG2056	Na+-H+ antiporter family
E4186_08945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4186_08960	COG0483	inositol monophosphate 1-phosphatase activity
E4186_08975	COG0625	glutathione transferase activity
E4186_08985	COG0601	transmembrane transport
E4186_08990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4186_08995	COG0577	efflux transmembrane transporter activity
E4186_08995	COG1136	(ABC) transporter
E4186_09000	COG2814	Major facilitator Superfamily
E4186_09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4186_09025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4186_09030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4186_09035	COG0509	glycine decarboxylation via glycine cleavage system
E4186_09040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4186_09040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4186_09050	COG3039	Transposase
E4186_09080	COG3634	alkyl hydroperoxide reductase activity
E4186_09090	COG0517	IMP dehydrogenase activity
E4186_09095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4186_09100	COG0343	queuine tRNA-ribosyltransferase activity
E4186_09105	COG1862	Preprotein translocase
E4186_09110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4186_09115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4186_09130	COG0826	peptidase U32
E4186_09135	COG0826	peptidase U32
E4186_09140	COG3154	lipid carrier protein
E4186_09160	COG1104	cysteine desulfurase activity
E4186_09165	COG0822	iron-sulfur transferase activity
E4186_09175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4186_09180	COG0443	Heat shock 70 kDa protein
E4186_09185	COG0633	Ferredoxin
E4186_09195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4186_09200	COG0105	UTP biosynthetic process
E4186_09205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4186_09225	COG0124	histidyl-tRNA synthetase
E4186_09230	COG2976	Protein conserved in bacteria
E4186_09235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4186_09240	COG1160	GTP binding
E4186_09250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4186_09255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4186_09255	COG0047	phosphoribosylformylglycinamidine synthase activity
E4186_09260	COG1007	ATP synthesis coupled electron transport
E4186_09265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4186_09275	COG0713	ATP synthesis coupled electron transport
E4186_09280	COG0839	Belongs to the complex I subunit 6 family
E4186_09285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4186_09290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4186_09295	COG1034	ATP synthesis coupled electron transport
E4186_09310	COG0649	NAD binding
E4186_09310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4186_09315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4186_09320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4186_09325	COG1360	Flagellar Motor Protein
E4186_09330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4186_09340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4186_09385	COG4974	Belongs to the 'phage' integrase family
E4186_09395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4186_09400	COG1902	pentaerythritol trinitrate reductase activity
E4186_09405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4186_09410	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_09415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4186_09450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4186_09470	COG0724	RNA recognition motif
E4186_09475	COG4989	oxidoreductase activity
E4186_09500	COG3437	response regulator, receiver
E4186_09505	COG0583	DNA-binding transcription factor activity
E4186_09515	COG5001	Diguanylate cyclase
E4186_09515	COG3300	MHYT domain
E4186_09520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4186_09525	COG0778	Nitroreductase
E4186_09540	COG2814	Major facilitator Superfamily
E4186_09550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4186_09555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4186_09560	COG0539	negative regulation of cytoplasmic translation
E4186_09565	COG0776	regulation of translation
E4186_09575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4186_09595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4186_09600	COG0602	queuosine metabolic process
E4186_09605	COG3530	Putative quorum-sensing-regulated virulence factor
E4186_09610	COG2096	Adenosyltransferase
E4186_09620	COG5433	transposase activity
E4186_09625	COG5433	transposase activity
E4186_09630	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4186_09635	COG1757	Na H antiporter
E4186_09640	COG1435	thymidine kinase activity
E4186_09695	COG1002	Type II restriction enzyme, methylase subunits
E4186_09730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4186_09745	COG5642	Protein of unknown function (DUF2384)
E4186_09760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4186_09775	COG3550	peptidyl-serine autophosphorylation
E4186_09790	COG3328	transposase activity
E4186_09825	COG3436	PFAM IS66 Orf2 family protein
E4186_09830	COG4372	Transposase
E4186_09910	COG3039	Transposase
E4186_09935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4186_09950	COG2910	NAD(P)H-binding
E4186_09955	COG0583	DNA-binding transcription factor activity
E4186_09965	COG3708	Transcriptional regulator
E4186_09965	COG2207	Transcriptional regulator
E4186_09970	COG4774	siderophore transport
E4186_09980	COG0583	DNA-binding transcription factor activity
E4186_09985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4186_09995	COG0517	IMP dehydrogenase activity
E4186_10010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4186_10015	COG3046	protein related to deoxyribodipyrimidine photolyase
E4186_10035	COG3088	subunit of a heme lyase
E4186_10035	COG4235	cytochrome complex assembly
E4186_10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4186_10045	COG1138	Cytochrome C-type biogenesis protein
E4186_10050	COG3301	Polysulphide reductase, NrfD
E4186_10055	COG0437	4 iron, 4 sulfur cluster binding
E4186_10060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4186_10075	COG5433	transposase activity
E4186_10085	COG0247	lactate metabolic process
E4186_10090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4186_10095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4186_10100	COG3012	SEC-C Motif Domain Protein
E4186_10110	COG1846	Transcriptional regulator
E4186_10110	COG1940	carbohydrate kinase activity
E4186_10115	COG3290	protein histidine kinase activity
E4186_10120	COG4565	transcriptional regulatory protein
E4186_10140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4186_10145	COG0569	domain protein
E4186_10145	COG2985	domain, Protein
E4186_10160	COG0556	nucleotide-excision repair
E4186_10170	COG0586	Pfam SNARE associated Golgi protein
E4186_10180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4186_10185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4186_10195	COG2719	SpoVR family
E4186_10200	COG2718	Belongs to the UPF0229 family
E4186_10205	COG2766	serine protein kinase
E4186_10210	COG0514	ATP-dependent DNA helicase (RecQ)
E4186_10215	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4186_10220	COG0814	amino acid
E4186_10250	COG0058	SHG alpha-glucan phosphorylase activity
E4186_10260	COG0471	metal ion transport
E4186_10265	COG3118	belongs to the thioredoxin family
E4186_10275	COG1132	(ABC) transporter
E4186_10280	COG1132	(ABC) transporter
E4186_10295	COG2501	S4 domain
E4186_10325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4186_10330	COG2329	Antibiotic biosynthesis monooxygenase
E4186_10335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4186_10340	COG0673	inositol 2-dehydrogenase activity
E4186_10345	COG0583	DNA-binding transcription factor activity
E4186_10355	COG1560	Kdo2-lipid A biosynthetic process
E4186_10360	COG1560	Kdo2-lipid A biosynthetic process
E4186_10385	COG0417	DNA replication proofreading
E4186_10400	COG5433	transposase activity
E4186_10425	COG5433	transposase activity
E4186_10480	COG3328	transposase activity
E4186_10515	COG0307	riboflavin synthase, alpha
E4186_10525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4186_10530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4186_10535	COG0697	spore germination
E4186_10540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4186_10575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4186_10580	COG3099	Belongs to the UPF0263 family
E4186_10585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4186_10590	COG2894	cell division
E4186_10595	COG0850	regulation of cytokinetic process
E4186_10600	COG3100	YcgL domain-containing protein
E4186_10605	COG2951	lytic endotransglycosylase activity
E4186_10610	COG1760	l-serine dehydratase
E4186_10620	COG1760	l-serine dehydratase
E4186_10625	COG3123	guanosine phosphorylase activity
E4186_10630	COG1301	dicarboxylic acid transport
E4186_10645	COG2067	long-chain fatty acid transport protein
E4186_10650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4186_10655	COG2067	long-chain fatty acid transport protein
E4186_10660	COG2067	long-chain fatty acid transport protein
E4186_10670	COG1595	DNA-templated transcription, initiation
E4186_10680	COG2304	oxidoreductase activity
E4186_10705	COG0714	Associated with various cellular activities
E4186_10710	COG0183	Belongs to the thiolase family
E4186_10715	COG1024	Enoyl-CoA hydratase
E4186_10715	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4186_10725	COG4681	YaeQ
E4186_10750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4186_10765	COG3134	Outer membrane lipoprotein
E4186_10770	COG0318	PFAM AMP-dependent synthetase and ligase
E4186_10775	COG2378	regulation of single-species biofilm formation
E4186_10785	COG0140	phosphoribosyl-ATP diphosphatase activity
E4186_10785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4186_10790	COG0107	imidazoleglycerol-phosphate synthase activity
E4186_10795	COG2198	Histidine kinase
E4186_10795	COG0784	Response regulator, receiver
E4186_10795	COG2205	protein histidine kinase activity
E4186_10805	COG3437	response regulator, receiver
E4186_10810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4186_10815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4186_10820	COG0131	Imidazoleglycerol-phosphate dehydratase
E4186_10820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4186_10825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4186_10830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4186_10835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4186_10845	COG1199	ATP-dependent helicase activity
E4186_10850	COG1214	PFAM Peptidase M22, glycoprotease
E4186_10860	COG0596	Alpha beta hydrolase
E4186_10865	COG0318	PFAM AMP-dependent synthetase and ligase
E4186_10870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4186_10880	COG0697	spore germination
E4186_10890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4186_10895	COG2832	Protein of unknown function (DUF454)
E4186_10900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4186_10910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4186_10915	COG1335	isochorismatase
E4186_10945	COG2197	response regulator
E4186_10950	COG0617	tRNA 3'-terminal CCA addition
E4186_10950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4186_10950	COG0517	IMP dehydrogenase activity
E4186_10955	COG1643	Atp-dependent helicase
E4186_10965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4186_10975	COG3437	response regulator, receiver
E4186_10980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4186_10985	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4186_10990	COG0709	Synthesizes selenophosphate from selenide and ATP
E4186_11000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4186_11005	COG0840	transmembrane signaling receptor activity
E4186_11010	COG1254	Belongs to the acylphosphatase family
E4186_11020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4186_11020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4186_11025	COG0489	protein tyrosine kinase activity
E4186_11030	COG0572	uridine kinase
E4186_11035	COG0717	Belongs to the dCTP deaminase family
E4186_11040	COG0306	phosphate transporter
E4186_11045	COG4584	PFAM Integrase catalytic
E4186_11055	COG1530	ribonuclease E activity
E4186_11065	COG0546	phosphoglycolate phosphatase activity
E4186_11070	COG0424	maF-like protein
E4186_11080	COG1399	metal-binding, possibly nucleic acid-binding protein
E4186_11085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4186_11090	COG0416	fatty acid biosynthetic process
E4186_11095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4186_11105	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_11110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4186_11120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4186_11125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4186_11130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4186_11135	COG0470	DNA polymerase III
E4186_11140	COG0084	hydrolase, TatD family'
E4186_11155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4186_11155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4186_11160	COG3008	intermembrane lipid transfer
E4186_11165	COG2995	paraquat-inducible protein a
E4186_11175	COG3141	response to X-ray
E4186_11185	COG1067	ATP-dependent peptidase activity
E4186_11190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4186_11215	COG0116	Belongs to the methyltransferase superfamily
E4186_11215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4186_11225	COG0167	dihydroorotate dehydrogenase activity
E4186_11230	COG2902	Dehydrogenase
E4186_11240	COG0308	aminopeptidase N
E4186_11250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4186_11255	COG1956	GAF domain-containing protein
E4186_11265	COG3278	Belongs to the heme-copper respiratory oxidase family
E4186_11280	COG2010	Cytochrome c
E4186_11305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4186_11310	COG0589	response to stress
E4186_11315	COG0037	tRNA processing
E4186_11330	COG0625	glutathione transferase activity
E4186_11335	COG1869	D-ribose catabolic process
E4186_11340	COG1129	ABC transporter
E4186_11345	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4186_11350	COG1879	ABC-type sugar transport system periplasmic component
E4186_11355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4186_11360	COG1609	Transcriptional regulator
E4186_11365	COG5001	Diguanylate cyclase
E4186_11365	COG3300	MHYT domain
E4186_11390	COG2205	protein histidine kinase activity
E4186_11390	COG0784	Response regulator, receiver
E4186_11395	COG0776	regulation of translation
E4186_11400	COG0072	phenylalanine-tRNA ligase activity
E4186_11400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4186_11405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4186_11410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4186_11415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4186_11420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4186_11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4186_11460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4186_11470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4186_11475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4186_11480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4186_11485	COG4372	Transposase
E4186_11500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4186_11505	COG3313	Fe-S protein
E4186_11510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4186_11510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4186_11510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4186_11515	COG1105	Belongs to the carbohydrate kinase PfkB family
E4186_11520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_11520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_11525	COG1609	Transcriptional regulator
E4186_11530	COG0814	amino acid
E4186_11535	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4186_11540	COG0513	Belongs to the DEAD box helicase family
E4186_11550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4186_11555	COG2890	protein-(glutamine-N5) methyltransferase activity
E4186_11560	COG2840	Smr protein MutS2
E4186_11570	COG0406	alpha-ribazole phosphatase activity
E4186_11600	COG2824	Alkylphosphonate utilization operon protein PhnA
E4186_11620	COG0384	phenazine biosynthesis protein PhzF
E4186_11655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4186_11660	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4186_11670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4186_11675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4186_11685	COG0205	6-phosphofructokinase activity
E4186_11690	COG1473	amidohydrolase
E4186_11695	COG1011	Hydrolase
E4186_11700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4186_11750	COG3593	DNA synthesis involved in DNA repair
E4186_11765	COG0583	DNA-binding transcription factor activity
E4186_11770	COG0730	response to heat
E4186_11795	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4186_11805	COG0386	Belongs to the glutathione peroxidase family
E4186_11810	COG0513	Belongs to the DEAD box helicase family
E4186_11815	COG0456	acetyltransferase
E4186_11840	COG3039	Transposase
E4186_11860	COG3706	GGDEF domain
E4186_11875	COG0583	DNA-binding transcription factor activity
E4186_11880	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_11885	COG2723	6-phospho-beta-galactosidase activity
E4186_11890	COG0583	DNA-binding transcription factor activity
E4186_11895	COG3706	GGDEF domain
E4186_11905	COG0243	molybdopterin cofactor binding
E4186_11910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4186_11915	COG3039	Transposase
E4186_11930	COG0730	response to heat
E4186_11940	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_11950	COG1024	Enoyl-CoA hydratase
E4186_11955	COG1024	Enoyl-CoA hydratase
E4186_11960	COG1960	acyl-CoA dehydrogenase activity
E4186_11970	COG1960	acyl-CoA dehydrogenase activity
E4186_11975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4186_11980	COG1024	Enoyl-CoA hydratase
E4186_12005	COG1584	GPR1 FUN34 yaaH family protein
E4186_12020	COG1115	amino acid carrier protein
E4186_12025	COG1024	Enoyl-CoA hydratase
E4186_12040	COG3162	membrane
E4186_12045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4186_12050	COG0488	(ABC) transporter
E4186_12055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4186_12060	COG0776	regulation of translation
E4186_12065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4186_12070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4186_12075	COG0740	serine-type endopeptidase activity
E4186_12080	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4186_12100	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4186_12105	COG1136	(ABC) transporter
E4186_12110	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4186_12120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4186_12125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4186_12130	COG4166	transmembrane transport
E4186_12135	COG0697	spore germination
E4186_12145	COG2062	phosphohistidine phosphatase, SixA
E4186_12175	COG0519	Catalyzes the synthesis of GMP from XMP
E4186_12175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4186_12180	COG0517	IMP dehydrogenase activity
E4186_12180	COG0516	GMP reductase activity
E4186_12190	COG0366	Alpha amylase catalytic
E4186_12190	COG1874	Beta-galactosidase
E4186_12200	COG1570	exodeoxyribonuclease VII activity
E4186_12210	COG2885	chlorophyll binding
E4186_12215	COG2199	diguanylate cyclase activity
E4186_12230	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4186_12240	COG3768	UPF0283 membrane protein
E4186_12245	COG3106	COG3106 Predicted ATPase
E4186_12260	COG1842	Phage shock protein A
E4186_12265	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4186_12275	COG4168	peptide transport system, permease
E4186_12280	COG4171	peptide transport system, permease
E4186_12290	COG4172	Belongs to the ABC transporter superfamily
E4186_12300	COG1609	Transcriptional regulator
E4186_12305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4186_12305	COG1263	PTS System
E4186_12310	COG2723	6-phospho-beta-galactosidase activity
E4186_12315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4186_12320	COG1286	toxin biosynthetic process
E4186_12325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4186_12330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4186_12335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4186_12340	COG1674	ftsk spoiiie
E4186_12340	COG0531	amino acid
E4186_12350	COG0686	Belongs to the AlaDH PNT family
E4186_12355	COG0492	ferredoxin-NADP+ reductase activity
E4186_12360	COG3706	GGDEF domain
E4186_12365	COG3134	Outer membrane lipoprotein
E4186_12370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4186_12375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4186_12380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4186_12385	COG0542	response to heat
E4186_12390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4186_12395	COG1278	Cold shock
E4186_12400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4186_12415	COG1944	ATP diphosphatase activity
E4186_12420	COG2116	formate transmembrane transporter activity
E4186_12425	COG1882	Formate acetyltransferase
E4186_12430	COG2983	Belongs to the UPF0260 family
E4186_12445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4186_12450	COG0045	succinate-CoA ligase (ADP-forming) activity
E4186_12455	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4186_12460	COG0567	Dehydrogenase, E1 component
E4186_12475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4186_12500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4186_12505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4186_12505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4186_12515	COG3069	C4-dicarboxylate transmembrane transporter activity
E4186_12530	COG1451	nucleotide metabolic process
E4186_12545	COG0254	rRNA binding
E4186_12550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4186_12560	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4186_12565	COG1129	ABC transporter
E4186_12570	COG1879	ABC-type sugar transport system periplasmic component
E4186_12575	COG1069	ribulokinase activity
E4186_12585	COG2160	L-arabinose isomerase activity
E4186_12590	COG0583	DNA-binding transcription factor activity
E4186_12595	COG0436	Aminotransferase
E4186_12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4186_12615	COG0392	lysyltransferase activity
E4186_12615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4186_12620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4186_12625	COG2925	Exonuclease
E4186_12635	COG3345	alpha-galactosidase
E4186_12640	COG1380	Effector of murein hydrolase LrgA
E4186_12645	COG1346	cytolysis
E4186_12650	COG0295	cytidine deaminase activity
E4186_12655	COG1022	Amp-dependent synthetase and ligase
E4186_12670	COG0861	Integral membrane protein TerC family
E4186_12675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4186_12680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4186_12685	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4186_12705	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4186_12705	COG0644	oxidoreductase
E4186_12730	COG4771	TonB-dependent receptor
E4186_12735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4186_12740	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4186_12745	COG1120	ATPase activity
E4186_12755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4186_12760	COG3321	synthase
E4186_12760	COG0318	PFAM AMP-dependent synthetase and ligase
E4186_12760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4186_12760	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_12760	COG0300	oxidoreductase activity
E4186_12770	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_12775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4186_12780	COG1535	isochorismatase
E4186_12780	COG3433	isochorismatase activity
E4186_12785	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4186_12805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4186_12810	COG3300	MHYT domain
E4186_12810	COG5001	Diguanylate cyclase
E4186_12825	COG0840	transmembrane signaling receptor activity
E4186_12830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4186_12835	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4186_12840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4186_12845	COG0563	adenylate kinase activity
E4186_12850	COG0326	Molecular chaperone. Has ATPase activity
E4186_12855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4186_12860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4186_12865	COG0298	carbon dioxide binding
E4186_12875	COG0309	Hydrogenase expression formation protein (HypE)
E4186_12880	COG0375	protein maturation
E4186_12885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4186_12890	COG1124	(ABC) transporter
E4186_12900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4186_12905	COG0601	transmembrane transport
E4186_12915	COG1773	rubredoxin
E4186_12920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4186_12925	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4186_12930	COG5557	Pfam Polysulphide reductase, NrfD
E4186_12935	COG0437	4 iron, 4 sulfur cluster binding
E4186_12940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4186_12965	COG0659	secondary active sulfate transmembrane transporter activity
E4186_12980	COG2308	Evidence 4 Homologs of previously reported genes of
E4186_13015	COG0672	)-iron permease
E4186_13040	COG2814	Major facilitator Superfamily
E4186_13060	COG1136	(ABC) transporter
E4186_13075	COG3039	Transposase
E4186_13095	COG1139	Iron-sulfur cluster binding protein
E4186_13100	COG0247	lactate metabolic process
E4186_13105	COG1620	l-lactate permease
E4186_13110	COG0583	DNA-binding transcription factor activity
E4186_13120	COG2315	Protein conserved in bacteria
E4186_13135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4186_13140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4186_13140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4186_13150	COG0527	aspartate kinase activity
E4186_13160	COG1368	sulfuric ester hydrolase activity
E4186_13180	COG0393	Putative heavy-metal-binding
E4186_13185	COG1252	NADH dehydrogenase
E4186_13190	COG3150	esterase
E4186_13205	COG2354	Protein conserved in bacteria
E4186_13215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4186_13220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4186_13255	COG0537	adenosine 5'-monophosphoramidase activity
E4186_13275	COG3561	AntA/AntB antirepressor
E4186_13445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4186_13510	COG3646	Phage regulatory protein
E4186_13510	COG3645	SOS response
E4186_13550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4186_13580	COG2974	May be involved in recombination
E4186_13625	COG0582	viral genome integration into host DNA
E4186_13630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4186_13645	COG1301	dicarboxylic acid transport
E4186_13655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4186_13660	COG0861	Integral membrane protein TerC family
E4186_13670	COG0444	Belongs to the ABC transporter superfamily
E4186_13675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4186_13680	COG0601	transmembrane transport
E4186_13690	COG2095	MarC family integral membrane protein
E4186_13695	COG1012	belongs to the aldehyde dehydrogenase family
E4186_13695	COG1454	alcohol dehydrogenase
E4186_13705	COG3275	phosphorelay sensor kinase activity
E4186_13710	COG3279	Response regulator of the LytR AlgR family
E4186_13715	COG1966	Carbon starvation protein
E4186_13720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4186_13720	COG3264	Mechanosensitive ion channel
E4186_13730	COG1566	PFAM secretion protein HlyD family protein
E4186_13735	COG1061	Type III restriction enzyme res subunit
E4186_13740	COG2027	D-alanyl-D-alanine carboxypeptidase
E4186_13745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4186_13755	COG0436	Aminotransferase
E4186_13760	COG1288	antiporter activity
E4186_13765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4186_13810	COG3039	Transposase
E4186_13830	COG0697	spore germination
E4186_13835	COG4657	Part of a membrane complex involved in electron transport
E4186_13840	COG2878	Part of a membrane complex involved in electron transport
E4186_13845	COG4656	Part of a membrane complex involved in electron transport
E4186_13850	COG4658	electron transport chain
E4186_13855	COG4659	FMN binding
E4186_13860	COG4660	Part of a membrane complex involved in electron transport
E4186_13865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4186_13870	COG0346	lactoylglutathione lyase activity
E4186_13885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4186_13895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4186_13900	COG1086	Polysaccharide biosynthesis protein
E4186_13905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4186_13915	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E4186_13920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4186_13935	COG2089	acid synthase
E4186_13970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4186_13975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4186_13980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4186_13995	COG0301	tRNA thio-modification
E4186_13995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4186_14030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4186_14075	COG0328	RNA-DNA hybrid ribonuclease activity
E4186_14120	COG3436	PFAM IS66 Orf2 family protein
E4186_14125	COG4372	Transposase
E4186_14140	COG4953	penicillin-binding protein 1C
E4186_14145	COG2373	Large extracellular alpha-helical protein
E4186_14175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4186_14185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4186_14195	COG4160	amino acid transport
E4186_14205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_14215	COG2431	L-lysine efflux transmembrane transporter activity
E4186_14220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4186_14235	COG1228	amidohydrolase
E4186_14245	COG1393	Belongs to the ArsC family
E4186_14255	COG4783	chaperone-mediated protein folding
E4186_14285	COG3842	ATPase activity
E4186_14290	COG3833	ABC-type maltose transport systems, permease component
E4186_14295	COG1175	transmembrane transport
E4186_14300	COG2182	Extracellular solute-binding protein
E4186_14305	COG3081	Nucleoid-associated protein
E4186_14310	COG3082	Protein of unknown function (DUF1414)
E4186_14315	COG3083	sulfuric ester hydrolase activity
E4186_14325	COG1770	oligopeptidase
E4186_14345	COG4574	serine-type endopeptidase inhibitor activity
E4186_14350	COG3085	chromosome segregation
E4186_14360	COG0287	Prephenate dehydrogenase
E4186_14360	COG1605	Chorismate mutase
E4186_14365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4186_14370	COG0584	glycerophosphoryl diester phosphodiesterase
E4186_14375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4186_14380	COG1349	DNA-binding transcription factor activity
E4186_14385	COG2271	Major facilitator Superfamily
E4186_14390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4186_14395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4186_14400	COG0583	DNA-binding transcription factor activity
E4186_14425	COG0656	L-ascorbic acid biosynthetic process
E4186_14430	COG2814	Major facilitator Superfamily
E4186_14440	COG1294	oxidase, subunit
E4186_14450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4186_14465	COG1595	DNA-templated transcription, initiation
E4186_14480	COG2979	Protein of unknown function (DUF533)
E4186_14520	COG2807	transmembrane transport
E4186_14525	COG1187	pseudouridine synthase activity
E4186_14530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4186_14550	COG1061	Type III restriction enzyme res subunit
E4186_14575	COG1166	arginine decarboxylase activity
E4186_14590	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4186_14605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4186_14620	COG0583	DNA-binding transcription factor activity
E4186_14630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4186_14635	COG0840	transmembrane signaling receptor activity
E4186_14640	COG0302	gtp cyclohydrolase
E4186_14650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4186_14655	COG0596	Alpha beta hydrolase
E4186_14660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4186_14675	COG0314	molybdopterin synthase activity
E4186_14680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4186_14685	COG0315	cyclic pyranopterin monophosphate synthase activity
E4186_14690	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4186_14695	COG3005	denitrification pathway
E4186_14705	COG0348	domain, Protein
E4186_14710	COG0437	4 iron, 4 sulfur cluster binding
E4186_14715	COG0243	molybdopterin cofactor binding
E4186_14725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4186_14730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4186_14735	COG3850	Histidine kinase
E4186_14740	COG2197	response regulator
E4186_14765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4186_14775	COG0121	glutamine amidotransferase
E4186_14780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4186_14785	COG1960	acyl-CoA dehydrogenase activity
E4186_14790	COG0784	Response regulator, receiver
E4186_14790	COG3437	response regulator, receiver
E4186_14800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4186_14805	COG0328	RNA-DNA hybrid ribonuclease activity
E4186_14810	COG2226	methyltransferase
E4186_14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4186_14820	COG1388	LysM domain
E4186_14820	COG0741	lytic transglycosylase activity
E4186_14835	COG1607	acyl-coa hydrolase
E4186_14850	COG0741	lytic transglycosylase activity
E4186_14860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4186_14885	COG0729	surface antigen
E4186_14895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4186_14905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4186_14915	COG4134	Bacterial extracellular solute-binding protein
E4186_14925	COG4136	ATPase activity
E4186_14930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4186_14935	COG2951	lytic endotransglycosylase activity
E4186_14940	COG1846	Transcriptional regulator
E4186_14950	COG0033	Phosphoglucomutase
E4186_14955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4186_14960	COG0596	Alpha beta hydrolase
E4186_14975	COG0716	FMN binding
E4186_14985	COG0735	belongs to the Fur family
E4186_14990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4186_15000	COG2190	(PTS) system
E4186_15000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4186_15000	COG1263	PTS System
E4186_15005	COG0363	glucosamine-6-phosphate deaminase activity
E4186_15010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4186_15015	COG1940	carbohydrate kinase activity
E4186_15015	COG1846	Transcriptional regulator
E4186_15025	COG0217	transcriptional regulatory protein
E4186_15030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4186_15040	COG1801	Protein of unknown function DUF72
E4186_15045	COG4106	trans-aconitate 2-methyltransferase activity
E4186_15050	COG0500	methyltransferase
E4186_15070	COG0583	DNA-binding transcription factor activity
E4186_15075	COG0791	NLP P60 protein
E4186_15090	COG1309	transcriptional regulator
E4186_15125	COG0534	Mate efflux family protein
E4186_15135	COG2841	Protein conserved in bacteria
E4186_15140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4186_15140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4186_15140	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4186_15140	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4186_15150	COG3217	Mosc domain protein beta barrel domain protein
E4186_15150	COG0633	Ferredoxin
E4186_15150	COG0633	Ferredoxin
E4186_15150	COG3217	Mosc domain protein beta barrel domain protein
E4186_15155	COG0501	Belongs to the peptidase M48B family
E4186_15160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4186_15165	COG1073	alpha beta
E4186_15165	COG2226	methyltransferase
E4186_15170	COG0156	8-amino-7-oxononanoate synthase activity
E4186_15175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4186_15195	COG0017	Asparaginyl-tRNA synthetase
E4186_15200	COG0604	alcohol dehydrogenase
E4186_15200	COG1028	Short-chain dehydrogenase reductase Sdr
E4186_15200	COG3321	synthase
E4186_15210	COG1902	pentaerythritol trinitrate reductase activity
E4186_15220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4186_15235	COG1393	Belongs to the ArsC family
E4186_15240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4186_15245	COG1876	peptidase activity
E4186_15255	COG3263	regulation of cellular component size
E4186_15270	COG1280	lysine exporter protein (LysE YggA)
E4186_15300	COG0564	pseudouridine synthase activity
E4186_15310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4186_15315	COG0702	epimerase
E4186_15325	COG2867	negative regulation of translational initiation
E4186_15330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4186_15340	COG0582	viral genome integration into host DNA
E4186_15345	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4186_15355	COG3039	Transposase
E4186_15365	COG3039	Transposase
E4186_15375	COG5377	YqaJ viral recombinase family
E4186_15425	COG2003	Belongs to the UPF0758 family
E4186_15505	COG1136	(ABC) transporter
E4186_15515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4186_15530	COG5433	transposase activity
E4186_15545	COG2314	TM2 domain
E4186_15565	COG3039	Transposase
E4186_15605	COG3153	acetyltransferase
E4186_15640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4186_15650	COG0745	RESPONSE REGULATOR receiver
E4186_15665	COG4988	ABC transporter
E4186_15670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4186_15690	COG1720	tRNA m6t6A37 methyltransferase activity
E4186_15705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4186_15710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4186_15715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_15725	COG2190	(PTS) system
E4186_15730	COG3038	cytochrome b561
E4186_15740	COG0420	3'-5' exonuclease activity
E4186_15745	COG0456	acetyltransferase
E4186_15750	COG2974	May be involved in recombination
E4186_15765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4186_15770	COG1917	Cupin 2, conserved barrel domain protein
E4186_15770	COG1396	sequence-specific DNA binding
E4186_15785	COG0531	amino acid
E4186_15795	COG0531	amino acid
E4186_15805	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4186_15815	COG3384	dioxygenase
E4186_15825	COG1484	DNA-dependent DNA replication
E4186_15830	COG4584	PFAM Integrase catalytic
E4186_15835	COG0784	Response regulator, receiver
E4186_15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_15835	COG2198	Histidine kinase
E4186_15835	COG2205	protein histidine kinase activity
E4186_15910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4186_15920	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4186_15935	COG4263	nitrous-oxide reductase activity
E4186_15940	COG0348	domain, Protein
E4186_15940	COG3901	Regulator of nitric oxide reductase transcription
E4186_15960	COG1388	LysM domain
E4186_15960	COG1376	ErfK ybiS ycfS ynhG family protein
E4186_15975	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4186_15980	COG0791	NLP P60 protein
E4186_15990	COG3118	belongs to the thioredoxin family
E4186_16000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4186_16005	COG0788	formyltetrahydrofolate deformylase activity
E4186_16030	COG0739	heme binding
E4186_16030	COG0741	lytic transglycosylase activity
E4186_16030	COG1196	nuclear chromosome segregation
E4186_16035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4186_16040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4186_16045	COG0673	inositol 2-dehydrogenase activity
E4186_16090	COG1032	radical SAM domain protein
E4186_16095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_16105	COG3706	GGDEF domain
E4186_16110	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4186_16115	COG0733	neurotransmitter:sodium symporter activity
E4186_16145	COG0281	malic enzyme
E4186_16155	COG0534	Mate efflux family protein
E4186_16170	COG2233	PERMEase
E4186_16175	COG0095	Lipoate-protein ligase
E4186_16180	COG1115	amino acid carrier protein
E4186_16185	COG0019	diaminopimelate decarboxylase activity
E4186_16195	COG0678	peroxiredoxin activity
E4186_16200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4186_16210	COG1126	abc transporter atp-binding protein
E4186_16215	COG0765	amino acid transport
E4186_16220	COG4597	amino acid ABC transporter
E4186_16225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_16240	COG1131	(ABC) transporter
E4186_16245	COG0545	Peptidyl-prolyl cis-trans isomerase
E4186_16250	COG3142	Participates in the control of copper homeostasis
E4186_16255	COG1940	carbohydrate kinase activity
E4186_16265	COG4783	chaperone-mediated protein folding
E4186_16275	COG5002	protein histidine kinase activity
E4186_16280	COG0745	RESPONSE REGULATOR receiver
E4186_16285	COG0346	lactoylglutathione lyase activity
E4186_16290	COG3039	Transposase
E4186_16295	COG3706	GGDEF domain
E4186_16300	COG3284	Transcriptional regulator
E4186_16305	COG1012	belongs to the aldehyde dehydrogenase family
E4186_16315	COG0697	spore germination
E4186_16325	COG3290	protein histidine kinase activity
E4186_16330	COG0281	malic enzyme
E4186_16345	COG1566	PFAM secretion protein HlyD family protein
E4186_16370	COG0602	queuosine metabolic process
E4186_16375	COG1328	CTP reductase activity
E4186_16385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4186_16390	COG3115	cell septum assembly
E4186_16395	COG1196	nuclear chromosome segregation
E4186_16405	COG2860	membrane
E4186_16415	COG3108	Peptidase M15
E4186_16420	COG2989	Protein conserved in bacteria
E4186_16435	COG0463	Glycosyl transferase, family 2
E4186_16450	COG0366	Alpha amylase catalytic
E4186_16490	COG3706	GGDEF domain
E4186_16495	COG0037	tRNA processing
E4186_16500	COG3590	peptidase
E4186_16520	COG0531	amino acid
E4186_16525	COG0814	amino acid
E4186_16530	COG0583	DNA-binding transcription factor activity
E4186_16540	COG0825	malonyl-CoA metabolic process
E4186_16550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4186_16555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4186_16560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4186_16565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4186_16570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4186_16585	COG0750	zinc metalloprotease
E4186_16590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4186_16595	COG0575	Belongs to the CDS family
E4186_16600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4186_16605	COG0233	cytoplasmic translational termination
E4186_16610	COG0528	UMP kinase activity
E4186_16615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4186_16620	COG0052	Belongs to the universal ribosomal protein uS2 family
E4186_16625	COG0024	Methionine aminopeptidase
E4186_16630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4186_16635	COG2171	N-acyltransferase activity
E4186_16645	COG1263	PTS System
E4186_16645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4186_16655	COG4580	involved in the transport of maltose and maltodextrins
E4186_16665	COG0564	pseudouridine synthase activity
E4186_16670	COG3098	single-species biofilm formation
E4186_16695	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4186_16705	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4186_16705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4186_16715	COG3706	GGDEF domain
E4186_16720	COG1611	Belongs to the LOG family
E4186_16725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4186_16730	COG0473	3-isopropylmalate dehydrogenase activity
E4186_16740	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4186_16745	COG2363	Small membrane protein
E4186_16755	COG0583	DNA-binding transcription factor activity
E4186_16760	COG0840	transmembrane signaling receptor activity
E4186_16765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4186_16780	COG1477	protein flavinylation
E4186_16785	COG2871	sodium ion transport
E4186_16790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4186_16795	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4186_16800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4186_16805	COG1805	sodium ion transport
E4186_16810	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4186_16815	COG0271	Belongs to the BolA IbaG family
E4186_16820	COG2813	Specifically methylates the guanine in position
E4186_16830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4186_16840	COG2211	Major facilitator Superfamily
E4186_16845	COG3248	Nucleoside-binding outer membrane protein
E4186_16850	COG1666	GTP binding
E4186_16875	COG3039	Transposase
E4186_16890	COG3501	Rhs element vgr protein
E4186_16905	COG2771	luxR family
E4186_16910	COG0659	secondary active sulfate transmembrane transporter activity
E4186_16940	COG1393	Belongs to the ArsC family
E4186_16945	COG0798	PFAM Bile acid sodium symporter
E4186_16955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4186_16985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4186_16990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4186_16995	COG1151	hydroxylamine reductase activity
E4186_17000	COG0783	Belongs to the Dps family
E4186_17025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4186_17040	COG0300	oxidoreductase activity
E4186_17050	COG0415	Belongs to the DNA photolyase family
E4186_17055	COG0789	Transcriptional regulator
E4186_17060	COG3272	Protein of unknown function (DUF1722)
E4186_17085	COG0077	Prephenate dehydratase
E4186_17085	COG1605	Chorismate mutase
E4186_17115	COG5377	YqaJ viral recombinase family
E4186_17160	COG2003	Belongs to the UPF0758 family
E4186_17215	COG1715	Restriction endonuclease
E4186_17225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4186_17270	COG4467	Involved in initiation control of chromosome replication
E4186_17280	COG2963	transposase activity
E4186_17285	COG2826	transposase and inactivated derivatives, IS30 family
E4186_17355	COG4580	involved in the transport of maltose and maltodextrins
E4186_17365	COG3940	Belongs to the glycosyl hydrolase 43 family
E4186_17380	COG1175	transmembrane transport
E4186_17400	COG1609	Transcriptional regulator
E4186_17415	COG2133	pyrroloquinoline quinone binding
E4186_17425	COG1349	DNA-binding transcription factor activity
E4186_17430	COG2084	Dehydrogenase
E4186_17435	COG3395	kinase activity
E4186_17440	COG0235	Class ii aldolase
E4186_17445	COG3622	Belongs to the hyi family
E4186_17450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4186_17455	COG2610	gluconate transmembrane transporter activity
E4186_17475	COG0300	oxidoreductase activity
E4186_17500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4186_17520	COG3813	Protein conserved in bacteria
E4186_17530	COG0826	peptidase U32
E4186_17540	COG1280	lysine exporter protein (LysE YggA)
E4186_17575	COG2203	Gaf domain
E4186_17575	COG2200	EAL domain
E4186_17575	COG2199	diguanylate cyclase activity
E4186_17615	COG0114	fumarate hydratase activity
E4186_17625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4186_17625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4186_17625	COG0506	proline dehydrogenase activity
E4186_17630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4186_17650	COG0737	Belongs to the 5'-nucleotidase family
E4186_17675	COG0545	Peptidyl-prolyl cis-trans isomerase
E4186_17690	COG1047	Peptidyl-prolyl cis-trans
E4186_17695	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4186_17705	COG0784	Response regulator, receiver
E4186_17705	COG0835	chemotaxis
E4186_17710	COG0429	hydrolase of the alpha beta-hydrolase fold
E4186_17720	COG3089	Belongs to the UPF0270 family
E4186_17725	COG3954	Phosphoribulokinase
E4186_17740	COG1765	OsmC-like protein
E4186_17770	COG2205	protein histidine kinase activity
E4186_17775	COG2814	Major facilitator Superfamily
E4186_17800	COG0748	coenzyme F420 binding
E4186_17805	COG3721	Heme iron utilization protein
E4186_17815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4186_17840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4186_17850	COG0463	Glycosyl transferase, family 2
E4186_17855	COG0741	lytic transglycosylase activity
E4186_17860	COG0488	(ABC) transporter
E4186_17870	COG2252	PERMEase
E4186_17880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4186_17885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4186_17890	COG3178	'Phosphotransferase
E4186_17895	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4186_17905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4186_17910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4186_17915	COG2967	ApaG domain
E4186_17920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4186_17930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4186_17935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4186_17945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4186_17950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4186_17955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4186_17960	COG0142	geranyltranstransferase activity
E4186_17965	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4186_17970	COG0330	HflC and HflK could
E4186_17975	COG0330	HflC and HflK could
E4186_17980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4186_17985	COG1923	regulation of RNA biosynthetic process
E4186_17990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4186_17995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4186_18005	COG0802	atpase or kinase
E4186_18010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4186_18010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4186_18030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4186_18035	COG2011	ABC-type metal ion transport system permease component
E4186_18040	COG1464	Belongs to the NlpA lipoprotein family
E4186_18050	COG0840	transmembrane signaling receptor activity
E4186_18090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4186_18095	COG5002	protein histidine kinase activity
E4186_18095	COG2198	Histidine kinase
E4186_18095	COG0784	Response regulator, receiver
E4186_18130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4186_18135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4186_18140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4186_18145	COG2716	regulation of RNA biosynthetic process
E4186_18150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4186_18155	COG3013	Belongs to the UPF0304 family
E4186_18165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4186_18170	COG0280	phosphate acetyltransferase
E4186_18170	COG0857	belongs to the CobB CobQ family
E4186_18175	COG0440	acetolactate synthase activity
E4186_18180	COG0028	Belongs to the TPP enzyme family
E4186_18190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4186_18195	COG0671	phosphoesterase, PA-phosphatase related
E4186_18205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4186_18210	COG0473	3-isopropylmalate dehydrogenase activity
E4186_18215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4186_18220	COG0066	3-isopropylmalate dehydratase activity
E4186_18235	COG4143	(ABC) transporter
E4186_18240	COG1178	ABC-type Fe3 transport system permease component
E4186_18245	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4186_18250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4186_18320	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4186_18330	COG3706	GGDEF domain
E4186_18335	COG0513	Belongs to the DEAD box helicase family
E4186_18355	COG3039	Transposase
E4186_18365	COG0154	amidase activity
E4186_18370	COG2957	Belongs to the agmatine deiminase family
E4186_18390	COG1902	pentaerythritol trinitrate reductase activity
E4186_18400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4186_18410	COG3300	MHYT domain
E4186_18410	COG5001	Diguanylate cyclase
E4186_18415	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4186_18430	COG0456	acetyltransferase
E4186_18440	COG1022	Amp-dependent synthetase and ligase
E4186_18450	COG1794	racemase activity, acting on amino acids and derivatives
E4186_18465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4186_18480	COG0733	neurotransmitter:sodium symporter activity
E4186_18485	COG0733	neurotransmitter:sodium symporter activity
E4186_18500	COG0561	phosphatase activity
E4186_18530	COG1846	Transcriptional regulator
E4186_18535	COG2130	NADP-dependent
E4186_18560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4186_18565	COG1640	4-alpha-glucanotransferase
E4186_18570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4186_18580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4186_18655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4186_18660	COG2885	chlorophyll binding
E4186_18665	COG0823	Involved in the tonB-independent uptake of proteins
E4186_18680	COG0811	peptide transport
E4186_18685	COG0824	Thioesterase
E4186_18690	COG3790	cyd operon protein YbgE
E4186_18695	COG4890	Cyd operon protein YbgT
E4186_18700	COG1294	oxidase, subunit
E4186_18705	COG1271	oxidase subunit
E4186_18710	COG2255	four-way junction helicase activity
E4186_18715	COG0632	four-way junction helicase activity
E4186_18720	COG0442	prolyl-tRNA aminoacylation
E4186_18725	COG4221	oxidoreductase activity
E4186_18740	COG1024	Enoyl-CoA hydratase
E4186_18755	COG4166	transmembrane transport
E4186_18765	COG0840	transmembrane signaling receptor activity
E4186_18785	COG0513	Belongs to the DEAD box helicase family
E4186_18820	COG0457	Tetratricopeptide repeat
E4186_18820	COG3118	belongs to the thioredoxin family
E4186_18830	COG1215	transferase activity, transferring glycosyl groups
E4186_18855	COG1448	Aminotransferase
E4186_18870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4186_18875	COG1328	CTP reductase activity
E4186_18900	COG0840	transmembrane signaling receptor activity
E4186_18905	COG3397	chitin binding
E4186_18915	COG0583	DNA-binding transcription factor activity
E4186_18920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4186_18925	COG4208	sulfate ABC transporter
E4186_18930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4186_18940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4186_18970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4186_18975	COG0564	pseudouridine synthase activity
E4186_18995	COG0459	protein refolding
E4186_19000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4186_19005	COG0534	Mate efflux family protein
E4186_19010	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4186_19015	COG1027	Aspartate ammonia-lyase
E4186_19020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4186_19025	COG2918	glutathione biosynthetic process
E4186_19030	COG0612	Peptidase, M16
E4186_19035	COG1238	metal cluster binding
E4186_19040	COG1064	alcohol dehydrogenase
E4186_19070	COG0359	binds to the 23S rRNA
E4186_19075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4186_19080	COG0360	Binds together with S18 to 16S ribosomal RNA
E4186_19085	COG1914	H( )-stimulated, divalent metal cation uptake system
E4186_19100	COG2153	protein acetylation
E4186_19110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4186_19115	COG0557	exoribonuclease II activity
E4186_19120	COG3706	GGDEF domain
E4186_19125	COG1854	S-ribosylhomocysteine lyase activity
E4186_19140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4186_19140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4186_19180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4186_19185	COG1047	Peptidyl-prolyl cis-trans
E4186_19190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4186_19195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4186_19200	COG0196	riboflavin kinase activity
E4186_19205	COG0728	peptidoglycan biosynthetic process
E4186_19210	COG0268	Binds directly to 16S ribosomal RNA
E4186_19215	COG0640	Transcriptional regulator
E4186_19220	COG0583	DNA-binding transcription factor activity
E4186_19230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4186_19265	COG5433	transposase activity
E4186_19300	COG5642	Protein of unknown function (DUF2384)
E4186_19305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4186_19315	COG2194	sulfuric ester hydrolase activity
E4186_19325	COG3039	Transposase
E4186_19330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4186_19355	COG4974	Belongs to the 'phage' integrase family
E4186_19365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4186_19375	COG1051	belongs to the nudix hydrolase family
E4186_19390	COG0335	large ribosomal subunit rRNA binding
E4186_19395	COG0336	Belongs to the RNA methyltransferase TrmD family
E4186_19400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4186_19405	COG0228	four-way junction DNA binding
E4186_19410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4186_19415	COG4137	Cytochrome C assembly protein
E4186_19420	COG4536	flavin adenine dinucleotide binding
E4186_19430	COG1017	nitric oxide dioxygenase activity
E4186_19430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4186_19435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4186_19440	COG0039	L-malate dehydrogenase activity
E4186_19445	COG4160	amino acid transport
E4186_19450	COG4215	(ABC) transporter
E4186_19455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4186_19460	COG1126	abc transporter atp-binding protein
E4186_19465	COG1438	arginine binding
E4186_19470	COG2837	iron assimilation
E4186_19475	COG3842	ATPase activity
E4186_19485	COG1840	ABC-type Fe3 transport system, periplasmic component
E4186_19490	COG0347	Belongs to the P(II) protein family
E4186_19505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4186_19510	COG0583	DNA-binding transcription factor activity
E4186_19525	COG1929	Belongs to the glycerate kinase type-1 family
E4186_19530	COG2610	gluconate transmembrane transporter activity
E4186_19535	COG3835	regulator
E4186_19540	COG3112	Uncharacterised protein family (UPF0231)
E4186_19560	COG1872	DUF167
E4186_19565	COG0762	integral membrane protein
E4186_19570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4186_19575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4186_19590	COG3022	response to hydroperoxide
E4186_19595	COG0513	Belongs to the DEAD box helicase family
E4186_19600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4186_19620	COG0735	belongs to the Fur family
E4186_19625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4186_19640	COG0776	regulation of translation
E4186_19645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4186_19655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4186_19670	COG0560	Phosphoserine phosphatase
E4186_19680	COG3064	Membrane
E4186_19695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4186_19700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4186_19705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4186_19715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4186_19720	COG0084	hydrolase, TatD family'
E4186_19740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4186_19745	COG0004	ammonium transporteR
E4186_19765	COG0795	lipopolysaccharide-transporting ATPase activity
E4186_19770	COG0795	lipopolysaccharide-transporting ATPase activity
E4186_19775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4186_19780	COG2927	DNA polymerase III (CHI subunit)
E4186_19795	COG1253	flavin adenine dinucleotide binding
E4186_19800	COG0586	Pfam SNARE associated Golgi protein
E4186_19805	COG1686	Belongs to the peptidase S11 family
E4186_19840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4186_19845	COG0527	aspartate kinase activity
E4186_19850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4186_19860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4186_19865	COG1546	Belongs to the CinA family
E4186_19875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4186_19895	COG3068	Protein conserved in bacteria
E4186_19905	COG0739	heme binding
E4186_19925	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4186_19930	COG1121	(ABC) transporter
E4186_19935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4186_19940	COG0583	DNA-binding transcription factor activity
E4186_19950	COG1573	uracil-dna glycosylase
E4186_19955	COG2962	Rard protein
E4186_19960	COG2827	Endonuclease containing a URI domain
E4186_19975	COG1842	Phage shock protein A
E4186_19980	COG0204	Acyl-transferase
E4186_20000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4186_20090	COG1051	belongs to the nudix hydrolase family
E4186_20095	COG3150	esterase
E4186_20105	COG3151	Protein conserved in bacteria
E4186_20110	COG0494	nUDIX hydrolase
E4186_20115	COG1538	Outer membrane efflux protein
E4186_20120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4186_20120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4186_20125	COG1560	Kdo2-lipid A biosynthetic process
E4186_20140	COG2771	luxR family
E4186_20155	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4186_20160	COG2213	PTS system mannitol-specific
E4186_20160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4186_20165	COG0246	Mannitol dehydrogenase
E4186_20170	COG3722	fumarate hydratase activity
E4186_20195	COG1671	Belongs to the UPF0178 family
E4186_20210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4186_20215	COG0513	Belongs to the DEAD box helicase family
E4186_20240	COG1575	Belongs to the MenA family. Type 1 subfamily
E4186_20245	COG1169	isochorismate synthase
E4186_20250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4186_20255	COG0596	Alpha beta hydrolase
E4186_20260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4186_20265	COG1441	menaquinone biosynthetic process
E4186_20270	COG0318	PFAM AMP-dependent synthetase and ligase
E4186_20275	COG3291	Pkd domain containing protein
E4186_20280	COG2949	membrane
E4186_20285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4186_20295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4186_20325	COG2873	o-acetylhomoserine
E4186_20335	COG1979	alcohol dehydrogenase
E4186_20350	COG4221	oxidoreductase activity
E4186_20400	COG3047	cAMP biosynthetic process
E4186_20405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4186_20410	COG2197	response regulator
E4186_20445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4186_20470	COG5433	transposase activity
E4186_20485	COG1396	sequence-specific DNA binding
E4186_20510	COG1278	Cold shock
E4186_20515	COG2205	protein histidine kinase activity
E4186_20520	COG0745	RESPONSE REGULATOR receiver
E4186_20540	COG3706	GGDEF domain
E4186_20545	COG0347	Belongs to the P(II) protein family
E4186_20550	COG0004	ammonium transporteR
E4186_20565	COG0346	lactoylglutathione lyase activity
E4186_20575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4186_20580	COG1074	ATP-dependent DNA helicase activity
E4186_20585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4186_20590	COG2259	Doxx family
E4186_20595	COG1741	Belongs to the pirin family
E4186_20605	COG0583	DNA-binding transcription factor activity
E4186_20630	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4186_20640	COG3842	ATPase activity
E4186_20650	COG2199	diguanylate cyclase activity
E4186_20650	COG2203	Gaf domain
E4186_20670	COG0456	acetyltransferase
E4186_20670	COG0454	-acetyltransferase
E4186_20675	COG0753	catalase activity
E4186_20700	COG0628	permease
E4186_20710	COG3284	Transcriptional regulator
E4186_20725	COG1461	Dihydroxyacetone kinase
E4186_20730	COG2376	Dihydroxyacetone kinase
E4186_20735	COG2252	PERMEase
E4186_20740	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4186_20775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4186_20780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4186_20785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4186_20790	COG0049	tRNA binding
E4186_20795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4186_20800	COG2168	tRNA wobble position uridine thiolation
E4186_20820	COG2964	Protein conserved in bacteria
E4186_20825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4186_20830	COG0085	RNA polymerase activity
E4186_20835	COG0222	ribosome binding
E4186_20840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4186_20845	COG0081	regulation of translation
E4186_20850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4186_20855	COG0250	Participates in transcription elongation, termination and antitermination
E4186_20870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4186_20895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4186_20900	COG0569	domain protein
E4186_20905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4186_20910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4186_20915	COG3005	denitrification pathway
E4186_20920	COG0243	molybdopterin cofactor binding
E4186_20930	COG2205	protein histidine kinase activity
E4186_20935	COG0745	RESPONSE REGULATOR receiver
E4186_20950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4186_20970	COG2204	response regulator
E4186_20980	COG2205	protein histidine kinase activity
E4186_21000	COG0516	GMP reductase activity
E4186_21000	COG0517	IMP dehydrogenase activity
E4186_21005	COG5413	integral membrane protein
E4186_21015	COG1522	sequence-specific DNA binding
E4186_21020	COG2502	aspartate--ammonia ligase
E4186_21025	COG0542	response to heat
E4186_21035	COG0564	pseudouridine synthase activity
E4186_21040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4186_21045	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4186_21055	COG3681	Belongs to the UPF0597 family
E4186_21060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4186_21065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4186_21070	COG1979	alcohol dehydrogenase
E4186_21075	COG2207	Transcriptional regulator
E4186_21080	COG3040	lipid binding
E4186_21110	COG0540	Belongs to the ATCase OTCase family
E4186_21115	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4186_21120	COG1438	arginine binding
E4186_21125	COG1288	antiporter activity
E4186_21130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4186_21155	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4186_21170	COG3250	beta-galactosidase activity
E4186_21175	COG1609	Transcriptional regulator
E4186_21180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4186_21190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4186_21195	COG2017	converts alpha-aldose to the beta-anomer
E4186_21200	COG0667	Aldo Keto reductase
E4186_21205	COG1968	undecaprenyl-diphosphatase activity
E4186_21210	COG3806	Anti-sigma factor
E4186_21215	COG1595	DNA-templated transcription, initiation
E4186_21225	COG0018	arginyl-trna synthetase
E4186_21235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4186_21240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4186_21260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4186_21265	COG1131	(ABC) transporter
E4186_21270	COG0842	Transport permease protein
E4186_21275	COG0842	Transport permease protein
E4186_21280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4186_21295	COG2116	formate transmembrane transporter activity
E4186_21300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4186_21300	COG1648	precorrin-2 dehydrogenase activity
E4186_21305	COG2239	Acts as a magnesium transporter
E4186_21310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4186_21315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4186_21325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4186_21335	COG0514	ATP-dependent DNA helicase (RecQ)
E4186_21340	COG2050	protein possibly involved in aromatic compounds catabolism
E4186_21360	COG2258	MOSC domain
E4186_21365	COG1177	transmembrane transport
E4186_21370	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4186_21375	COG3842	ATPase activity
E4186_21395	COG0174	glutamine synthetase
E4186_21415	COG3045	CreA protein
E4186_21420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4186_21425	COG0443	Heat shock 70 kDa protein
E4186_21440	COG0366	Alpha amylase catalytic
E4186_21455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4186_21460	COG0745	RESPONSE REGULATOR receiver
E4186_21465	COG2205	protein histidine kinase activity
E4186_21475	COG0281	malic enzyme
E4186_21480	COG0702	epimerase
E4186_21485	COG0254	rRNA binding
E4186_21490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4186_21510	COG0129	dihydroxy-acid dehydratase activity
E4186_21520	COG3978	acetolactate synthase activity
E4186_21535	COG0606	chelatase, subunit chli
E4186_21540	COG0204	Acyl-transferase
E4186_21545	COG0204	Acyl-transferase
E4186_21550	COG1683	Conserved Protein
E4186_21560	COG1335	isochorismatase
E4186_21570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4186_21575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4186_21580	COG3639	organic phosphonate transmembrane transporter activity
E4186_21585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4186_21590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4186_21600	COG3084	Protein conserved in bacteria
E4186_21605	COG4251	negative regulation of phosphorylation
E4186_21605	COG3706	GGDEF domain
E4186_21605	COG5001	Diguanylate cyclase
E4186_21605	COG2203	Gaf domain
E4186_21610	COG0789	Transcriptional regulator
E4186_21620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4186_21625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4186_21640	COG1519	Transferase
E4186_21645	COG0859	PFAM glycosyl transferase family 9
E4186_21650	COG0463	Glycosyl transferase, family 2
E4186_21655	COG0859	PFAM glycosyl transferase family 9
E4186_21660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4186_21665	COG2990	Protein conserved in bacteria
E4186_21670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4186_21680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4186_21685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4186_21690	COG2003	Belongs to the UPF0758 family
E4186_21695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4186_21710	COG3039	Transposase
E4186_21725	COG2132	Multicopper oxidase
E4186_21775	COG0745	RESPONSE REGULATOR receiver
E4186_21790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4186_21795	COG1538	Outer membrane efflux protein
E4186_21800	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4186_21835	COG5433	transposase activity
E4186_21845	COG0756	dUTP diphosphatase activity
E4186_21855	COG1309	transcriptional regulator
E4186_21860	COG0668	transmembrane transport
E4186_21870	COG0166	Belongs to the GPI family
E4186_21875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4186_21880	COG0583	DNA-binding transcription factor activity
E4186_21890	COG0045	succinate-CoA ligase (ADP-forming) activity
E4186_21890	COG1042	CoA-binding domain protein
E4186_21890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4186_21920	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4186_21925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4186_21930	COG1739	Uncharacterized protein family UPF0029
E4186_21935	COG0006	proline dipeptidase activity
E4186_21940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4186_21945	COG1024	Enoyl-CoA hydratase
E4186_21945	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4186_21950	COG0183	Belongs to the thiolase family
E4186_21955	COG0745	RESPONSE REGULATOR receiver
E4186_21965	COG1653	transport
E4186_21975	COG0425	Belongs to the sulfur carrier protein TusA family
E4186_21980	COG0251	oxidation-reduction process
E4186_21985	COG2885	chlorophyll binding
E4186_22010	COG2818	Glycosylase
E4186_22015	COG0752	glycyl-tRNA synthetase alpha subunit
E4186_22020	COG0751	glycine-tRNA ligase activity
E4186_22050	COG0814	amino acid
E4186_22055	COG0814	amino acid
E4186_22060	COG3033	Beta-eliminating lyase
E4186_22070	COG0348	domain, Protein
E4186_22080	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4186_22085	COG1773	rubredoxin
E4186_22085	COG0426	domain, Protein
E4186_22090	COG3604	Transcriptional regulator
E4186_22095	COG1609	Transcriptional regulator
E4186_22135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4186_22150	COG2960	long-chain fatty acid transporting porin activity
E4186_22160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4186_22175	COG3118	belongs to the thioredoxin family
E4186_22185	COG0513	Belongs to the DEAD box helicase family
E4186_22190	COG0248	Ppx GppA phosphatase
E4186_22205	COG0742	ribosomal rna small subunit methyltransferase
E4186_22225	COG0084	hydrolase, TatD family'
E4186_22230	COG0805	protein transport
E4186_22235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4186_22240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4186_22245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4186_22250	COG3165	ubiquinone biosynthetic process from chorismate
E4186_22255	COG2226	methyltransferase
E4186_22260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4186_22265	COG0402	S-adenosylhomocysteine deaminase activity
E4186_22270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4186_22305	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4186_22310	COG0848	biopolymer transport protein
E4186_22315	COG0811	peptide transport
E4186_22320	COG0811	peptide transport
E4186_22330	COG2771	luxR family
E4186_22335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4186_22340	COG1349	DNA-binding transcription factor activity
E4186_22345	COG0745	RESPONSE REGULATOR receiver
E4186_22350	COG2205	protein histidine kinase activity
E4186_22365	COG4452	Inner membrane protein CreD
E4186_22370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4186_22375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4186_22380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4186_22385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4186_22390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4186_22395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4186_22400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4186_22410	COG0356	it plays a direct role in the translocation of protons across the membrane
E4186_22420	COG1475	DNA binding
E4186_22425	COG1192	Involved in chromosome partitioning
E4186_22430	COG0357	Ribosomal RNA small subunit methyltransferase G
E4186_22435	COG0445	tRNA wobble uridine modification
E4186_22440	COG0716	FMN binding
E4186_22445	COG4774	siderophore transport
E4186_22450	COG4615	Cyclic peptide transporter
E4186_22455	COG1120	ATPase activity
E4186_22460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4186_22465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4186_22475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4186_22480	COG0706	membrane insertase activity
E4186_22485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4186_22490	COG0594	ribonuclease P activity
E4186_22495	COG0230	Belongs to the bacterial ribosomal protein bL34 family