locus-tag	class	description
B224_0003	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B224_0005	COG1522	sequence-specific DNA binding
B224_0007	COG3135	benzoate transporter
B224_0008	COG1396	sequence-specific DNA binding
B224_0011	COG2926	Belongs to the UPF0265 family
B224_0014	COG3028	Belongs to the UPF0307 family
B224_0015	COG0312	modulator of DNA gyrase
B224_0016	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B224_0017	COG5007	Belongs to the BolA IbaG family
B224_0020	COG2854	intermembrane phospholipid transfer
B224_0023	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B224_0024	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B224_0025	COG1127	ABC transporter
B224_0026	COG0517	IMP dehydrogenase activity
B224_0026	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B224_0027	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B224_0028	COG3117	lipopolysaccharide transmembrane transporter activity
B224_0029	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B224_0030	COG1137	ATPase activity
B224_0034	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_0035	COG1660	Displays ATPase and GTPase activities
B224_0036	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_0043	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B224_0044	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B224_0046	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B224_0047	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B224_0048	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B224_0049	COG0723	plastoquinol--plastocyanin reductase activity
B224_0050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B224_0053	COG2857	Cytochrome c1
B224_0054	COG0625	glutathione transferase activity
B224_0055	COG2969	positive regulation of protein catabolic process
B224_0056	COG2823	Periplasmic or secreted lipoprotein
B224_0057	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B224_0059	COG0792	nuclease activity
B224_0061	COG3107	peptidoglycan biosynthetic process
B224_0062	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B224_0069	COG5433	transposase activity
B224_0078	COG2001	Belongs to the MraZ family
B224_0079	COG0275	rRNA processing
B224_0080	COG3116	cell division
B224_0083	COG0768	penicillin binding
B224_0086	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B224_0087	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B224_0088	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B224_0091	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B224_0093	COG0772	Belongs to the SEDS family
B224_0094	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B224_0096	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B224_0098	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B224_0099	COG0849	cell division
B224_0101	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B224_0102	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B224_0104	COG0653	protein targeting
B224_0107	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B224_0108	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B224_0111	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B224_0112	COG1459	type II secretion system
B224_0113	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B224_0114	COG5433	transposase activity
B224_0120	COG2186	Transcriptional regulator
B224_0121	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B224_0122	COG0508	dehydrogenase complex catalyzes the overall conversion of
B224_0125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B224_0126	COG3706	GGDEF domain
B224_0130	COG0840	transmembrane signaling receptor activity
B224_0131	COG1752	Esterase of the alpha-beta hydrolase superfamily
B224_0132	COG1049	propionate catabolic process, 2-methylcitrate cycle
B224_0134	COG2200	EAL domain
B224_0136	COG1280	lysine exporter protein (LysE YggA)
B224_0140	COG0523	cobalamin synthesis protein
B224_0144	COG0477	Major facilitator Superfamily
B224_0148	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B224_0149	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B224_0156	COG3385	transposase activity
B224_0166	COG5006	permease, DMT superfamily
B224_0167	COG1522	sequence-specific DNA binding
B224_0168	COG5433	transposase activity
B224_0169	COG0110	maltose O-acetyltransferase activity
B224_0172	COG0366	Alpha amylase catalytic
B224_0174	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_0174	COG1263	PTS System
B224_0176	COG1609	Transcriptional regulator
B224_0178	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_0179	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_0180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_0180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_0181	COG2723	6-phospho-beta-galactosidase activity
B224_0183	COG1447	Phosphotransferase system cellobiose-specific component IIA
B224_0185	COG1940	carbohydrate kinase activity
B224_0190	COG1609	Transcriptional regulator
B224_0193	COG0252	asparaginase activity
B224_0194	COG5433	transposase activity
B224_0199	COG1803	Methylglyoxal synthase
B224_0205	COG1444	tRNA N-acetyltransferase activity
B224_0206	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B224_0207	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B224_0208	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B224_0214	COG1612	heme a metabolic process
B224_0215	COG0109	protoheme IX farnesyltransferase activity
B224_0217	COG1012	belongs to the aldehyde dehydrogenase family
B224_0218	COG1177	transmembrane transport
B224_0219	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_0220	COG3842	ATPase activity
B224_0222	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B224_0224	COG0583	DNA-binding transcription factor activity
B224_0226	COG1757	Na H antiporter
B224_0229	COG0297	glycogen (starch) synthase activity
B224_0231	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B224_0232	COG2813	Specifically methylates the guanine in position
B224_0233	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B224_0234	COG2203	Gaf domain
B224_0234	COG5001	Diguanylate cyclase
B224_0234	COG3706	GGDEF domain
B224_0234	COG4251	negative regulation of phosphorylation
B224_0236	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_0238	COG2995	paraquat-inducible protein a
B224_0240	COG3008	intermembrane lipid transfer
B224_0240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B224_0241	COG3009	Protein conserved in bacteria
B224_0243	COG3240	lipase activity
B224_0247	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B224_0248	COG1194	a g-specific adenine glycosylase
B224_0251	COG3409	Peptidoglycan-binding domain 1 protein
B224_0251	COG3267	Type II secretory pathway component ExeA
B224_0253	COG0617	tRNA 3'-terminal CCA addition
B224_0255	COG0306	phosphate transporter
B224_0256	COG1392	Phosphate transport regulator
B224_0260	COG3133	Outer membrane lipoprotein
B224_0266	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B224_0267	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B224_0270	COG3031	protein transport across the cell outer membrane
B224_0274	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B224_0275	COG1459	type II secretion system
B224_0276	COG2165	general secretion pathway protein
B224_0278	COG2165	general secretion pathway protein
B224_0279	COG4795	General secretion pathway protein
B224_0282	COG3156	type II secretion system protein K
B224_0286	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B224_0290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_0293	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_0295	COG1011	Hydrolase
B224_0296	COG0494	nUDIX hydrolase
B224_0297	COG1218	3'(2'),5'-bisphosphate nucleotidase
B224_0298	COG0814	amino acid
B224_0300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_0304	COG0626	cystathionine gamma-synthase activity
B224_0306	COG0527	aspartate kinase activity
B224_0306	COG0460	homoserine dehydrogenase
B224_0308	COG1346	cytolysis
B224_0309	COG1380	Effector of murein hydrolase LrgA
B224_0310	COG0583	DNA-binding transcription factor activity
B224_0320	COG3447	MASE1 domain protein
B224_0320	COG5001	Diguanylate cyclase
B224_0320	COG5002	protein histidine kinase activity
B224_0323	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B224_0326	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B224_0327	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B224_0330	COG0137	argininosuccinate synthase activity
B224_0332	COG0165	Argininosuccinate lyase
B224_0335	COG3039	Transposase
B224_0342	COG0110	maltose O-acetyltransferase activity
B224_0344	COG3174	membrane
B224_0345	COG1505	serine-type exopeptidase activity
B224_0349	COG1028	Short-chain dehydrogenase reductase Sdr
B224_0352	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B224_0356	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B224_0357	COG4991	sh3 domain protein
B224_0359	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B224_0361	COG1940	carbohydrate kinase activity
B224_0362	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B224_0363	COG0126	phosphoglycerate kinase activity
B224_0365	COG0191	fructose-bisphosphate aldolase activity
B224_0366	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_0376	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B224_0379	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B224_0380	COG1595	DNA-templated transcription, initiation
B224_0385	COG0481	GTPase activity
B224_0387	COG0681	Belongs to the peptidase S26 family
B224_0388	COG0571	ribonuclease III activity
B224_0390	COG1381	Involved in DNA repair and RecF pathway recombination
B224_0391	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B224_0392	COG3023	N-Acetylmuramoyl-L-alanine amidase
B224_0393	COG4807	Protein conserved in bacteria
B224_0396	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_0399	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B224_0401	COG3956	TIGRFAM MazG family protein
B224_0403	COG0504	CTP synthase activity
B224_0405	COG0148	phosphopyruvate hydratase activity
B224_0407	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B224_0408	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B224_0411	COG0585	pseudouridine synthase activity
B224_0412	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B224_0413	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B224_0414	COG1238	metal cluster binding
B224_0415	COG4942	peptidase
B224_0415	COG1388	LysM domain
B224_0416	COG3039	Transposase
B224_0418	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B224_0419	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B224_0420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B224_0421	COG1610	YqeY-like protein
B224_0423	COG0358	DNA primase activity
B224_0424	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B224_0432	COG0151	Belongs to the GarS family
B224_0434	COG0138	bifunctional purine biosynthesis protein purh
B224_0438	COG3036	rescue of stalled ribosome
B224_0440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B224_0441	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B224_0443	COG2814	Major facilitator Superfamily
B224_0445	COG0673	inositol 2-dehydrogenase activity
B224_0448	COG1585	Membrane protein implicated in regulation of membrane protease activity
B224_0449	COG0330	HflC and HflK could
B224_0450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B224_0450	COG1648	precorrin-2 dehydrogenase activity
B224_0452	COG0175	sulfate reduction
B224_0454	COG2895	sulfate adenylyltransferase (ATP) activity
B224_0455	COG0471	metal ion transport
B224_0455	COG3273	potassium ion transport
B224_0457	COG0529	Catalyzes the synthesis of activated sulfate
B224_0458	COG3039	Transposase
B224_0459	COG3385	transposase activity
B224_0460	COG3039	Transposase
B224_0463	COG0840	transmembrane signaling receptor activity
B224_0472	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B224_0475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B224_0476	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B224_0477	COG0163	prenyltransferase activity
B224_0481	COG1131	(ABC) transporter
B224_0482	COG0842	Transport permease protein
B224_0485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B224_0486	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B224_0489	COG0617	tRNA 3'-terminal CCA addition
B224_0491	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_0492	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B224_0497	COG1489	DNA binding
B224_0498	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B224_0499	COG1643	Atp-dependent helicase
B224_0501	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B224_0502	COG0346	lactoylglutathione lyase activity
B224_0506	COG2076	Multidrug Resistance protein
B224_0507	COG0583	DNA-binding transcription factor activity
B224_0509	COG0671	phosphoesterase, PA-phosphatase related
B224_0513	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B224_0518	COG0316	Belongs to the HesB IscA family
B224_0522	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B224_0523	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_0526	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_0536	COG0745	RESPONSE REGULATOR receiver
B224_0538	COG3104	oligopeptide transport
B224_0539	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B224_0540	COG1555	photosystem II stabilization
B224_0542	COG2350	Protein conserved in bacteria
B224_0544	COG2917	probably involved in intracellular septation
B224_0545	COG0076	glutamate decarboxylase activity
B224_0547	COG1272	protein, Hemolysin III
B224_0549	COG0569	domain protein
B224_0549	COG2985	domain, Protein
B224_0556	COG3039	Transposase
B224_0557	COG5433	transposase activity
B224_0561	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B224_0563	COG1376	ErfK ybiS ycfS ynhG family protein
B224_0565	COG0668	transmembrane transport
B224_0568	COG2731	YhcH YjgK YiaL family protein
B224_0571	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_0572	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_0577	COG5433	transposase activity
B224_0578	COG0583	DNA-binding transcription factor activity
B224_0580	COG0477	Major facilitator Superfamily
B224_0592	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B224_0595	COG0488	(ABC) transporter
B224_0596	COG0517	IMP dehydrogenase activity
B224_0598	COG3039	Transposase
B224_0599	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B224_0603	COG2755	lipolytic protein G-D-S-L family
B224_0604	COG4181	ATPase activity
B224_0606	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B224_0607	COG1090	epimerase
B224_0610	COG2200	EAL domain
B224_0613	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_0614	COG2234	aminopeptidase activity
B224_0614	COG4935	Belongs to the peptidase S8 family
B224_0616	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B224_0617	COG3171	Protein conserved in bacteria
B224_0619	COG2066	Belongs to the glutaminase family
B224_0620	COG2897	thiosulfate sulfurtransferase activity
B224_0625	COG1132	(ABC) transporter
B224_0633	COG3039	Transposase
B224_0635	COG1609	Transcriptional regulator
B224_0637	COG2017	converts alpha-aldose to the beta-anomer
B224_0638	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B224_0641	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_0643	COG4412	M6 family metalloprotease domain protein
B224_0643	COG3291	Pkd domain containing protein
B224_0644	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B224_0647	COG3706	GGDEF domain
B224_0647	COG2203	Gaf domain
B224_0647	COG4251	negative regulation of phosphorylation
B224_0647	COG5001	Diguanylate cyclase
B224_0651	COG3706	GGDEF domain
B224_0654	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_0658	COG4628	conserved protein (DUF2132)
B224_0659	COG0688	phosphatidylethanolamine metabolic process
B224_0662	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B224_0663	COG1278	Cold shock
B224_0666	COG0840	transmembrane signaling receptor activity
B224_0668	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_0669	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_0677	COG0848	biopolymer transport protein
B224_0680	COG0811	peptide transport
B224_0681	COG0811	peptide transport
B224_0684	COG4206	TonB-dependent receptor
B224_0688	COG5433	transposase activity
B224_0691	COG4174	ABC transporter (Permease)
B224_0692	COG4239	(ABC) transporter, permease
B224_0693	COG0747	negative chemotaxis
B224_0695	COG0444	Belongs to the ABC transporter superfamily
B224_0696	COG4608	Belongs to the ABC transporter superfamily
B224_0699	COG2195	Cleaves the N-terminal amino acid of tripeptides
B224_0701	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B224_0709	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B224_0717	COG0243	molybdopterin cofactor binding
B224_0721	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B224_0721	COG1116	anion transmembrane transporter activity
B224_0723	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B224_0724	COG1116	anion transmembrane transporter activity
B224_0726	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_0726	COG2146	nitrite reductase [NAD(P)H] activity
B224_0728	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_0728	COG2146	nitrite reductase [NAD(P)H] activity
B224_0730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_0731	COG2313	pseudouridylate synthase activity
B224_0735	COG5433	transposase activity
B224_0737	COG1028	Short-chain dehydrogenase reductase Sdr
B224_0739	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B224_0742	COG0521	Mo-molybdopterin cofactor biosynthetic process
B224_0747	COG2966	Psort location CytoplasmicMembrane, score
B224_0749	COG3610	response to peptide
B224_0752	COG4175	Glycine betaine
B224_0753	COG4176	ABC-type proline glycine betaine transport system permease component
B224_0755	COG2113	Glycine betaine
B224_0756	COG0175	sulfate reduction
B224_0758	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_0760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B224_0761	COG0384	phenazine biosynthesis protein PhzF
B224_0762	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B224_0764	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B224_0768	COG5001	Diguanylate cyclase
B224_0771	COG0786	glutamate:sodium symporter activity
B224_0772	COG0252	asparaginase activity
B224_0773	COG3139	Protein of unknown function (DUF1315)
B224_0778	COG0616	signal peptide processing
B224_0781	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_0781	COG1902	pentaerythritol trinitrate reductase activity
B224_0783	COG0778	Nitroreductase
B224_0785	COG2264	protein methyltransferase activity
B224_0787	COG0604	alcohol dehydrogenase
B224_0788	COG0583	DNA-binding transcription factor activity
B224_0789	COG2190	(PTS) system
B224_0789	COG1263	PTS System
B224_0789	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_0791	COG4145	pantothenate transmembrane transporter activity
B224_0792	COG3924	membrane
B224_0793	COG0439	Biotin carboxylase
B224_0795	COG0511	ligase activity, forming carbon-carbon bonds
B224_0796	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B224_0798	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B224_0804	COG3381	protein complex oligomerization
B224_0808	COG3005	denitrification pathway
B224_0809	COG0745	RESPONSE REGULATOR receiver
B224_0811	COG1879	ABC-type sugar transport system periplasmic component
B224_0812	COG2205	protein histidine kinase activity
B224_0812	COG0784	Response regulator, receiver
B224_0812	COG2198	Histidine kinase
B224_0815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B224_0817	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B224_0818	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B224_0818	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B224_0824	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B224_0825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_0826	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B224_0827	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B224_0836	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B224_0838	COG0142	geranyltranstransferase activity
B224_0840	COG1722	exodeoxyribonuclease VII activity
B224_0842	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B224_0843	COG1360	Flagellar Motor Protein
B224_0844	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B224_0846	COG1534	Rna-binding protein
B224_0847	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B224_0848	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B224_0850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B224_0852	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B224_0854	COG0149	triose-phosphate isomerase activity
B224_0855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B224_0856	COG0779	Required for maturation of 30S ribosomal subunits
B224_0857	COG0195	Participates in both transcription termination and antitermination
B224_0860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B224_0861	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B224_0862	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B224_0864	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B224_0865	COG1185	polyribonucleotide nucleotidyltransferase activity
B224_0869	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B224_0871	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B224_0877	COG0312	modulator of DNA gyrase
B224_0880	COG0716	FMN binding
B224_0881	COG4974	Belongs to the 'phage' integrase family
B224_0888	COG0180	Tryptophanyl-tRNA synthetase
B224_0891	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B224_0892	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B224_0895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B224_0897	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B224_0905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B224_0907	COG0583	DNA-binding transcription factor activity
B224_0910	COG0583	DNA-binding transcription factor activity
B224_0914	COG3121	Chaperone
B224_0917	COG3188	usher protein
B224_0918	COG3121	Chaperone
B224_0921	COG0739	heme binding
B224_0925	COG3264	Mechanosensitive ion channel
B224_0925	COG1511	domain protein
B224_0927	COG0584	glycerophosphoryl diester phosphodiesterase
B224_0930	COG1053	succinate dehydrogenase
B224_0932	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B224_0933	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B224_0936	COG3214	Protein conserved in bacteria
B224_0937	COG4106	trans-aconitate 2-methyltransferase activity
B224_0941	COG0300	oxidoreductase activity
B224_0943	COG0745	RESPONSE REGULATOR receiver
B224_0944	COG0642	Histidine kinase
B224_0947	COG0516	GMP reductase activity
B224_0951	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B224_0952	COG3647	Membrane
B224_0955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B224_0958	COG3706	GGDEF domain
B224_0963	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_0965	COG0583	DNA-binding transcription factor activity
B224_0966	COG1278	Cold shock
B224_0968	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_0969	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_0970	COG1702	phosphate starvation-inducible protein PhoH
B224_0972	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B224_0973	COG4535	Mg2 and Co2 transporter CorC
B224_0975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B224_0977	COG2888	peptidyl-tyrosine sulfation
B224_0979	COG0495	leucyl-tRNA aminoacylation
B224_0985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B224_0986	COG0799	negative regulation of ribosome biogenesis
B224_0988	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B224_0989	COG0768	penicillin binding
B224_0991	COG0772	Belongs to the SEDS family
B224_0992	COG2951	lytic endotransglycosylase activity
B224_0993	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B224_0994	COG1686	Belongs to the peptidase S11 family
B224_0996	COG2921	Belongs to the UPF0250 family
B224_0997	COG0321	lipoyl(octanoyl) transferase activity
B224_0998	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B224_1001	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_1005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B224_1010	COG1970	mechanosensitive ion channel activity
B224_1017	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B224_1021	COG1012	belongs to the aldehyde dehydrogenase family
B224_1024	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_1032	COG0471	metal ion transport
B224_1032	COG0490	domain, Protein
B224_1033	COG0012	GTP binding
B224_1035	COG0193	aminoacyl-tRNA hydrolase activity
B224_1036	COG0737	Belongs to the 5'-nucleotidase family
B224_1038	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B224_1040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B224_1042	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B224_1043	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B224_1044	COG2890	protein-(glutamine-N5) methyltransferase activity
B224_1047	COG2912	Transglutaminase-like superfamily
B224_1049	COG1301	dicarboxylic acid transport
B224_1051	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B224_1057	COG5433	transposase activity
B224_1058	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B224_1060	COG1115	amino acid carrier protein
B224_1066	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B224_1067	COG1678	Uncharacterized ACR, COG1678
B224_1068	COG0189	ligase activity
B224_1070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B224_1072	COG3091	SprT-like family
B224_1074	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B224_1077	COG2801	Transposase and inactivated derivatives
B224_1083	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B224_1085	COG0739	heme binding
B224_1087	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_1090	COG3408	Glycogen debranching enzyme
B224_1090	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B224_1094	COG0583	DNA-binding transcription factor activity
B224_1096	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B224_1101	COG0583	DNA-binding transcription factor activity
B224_1102	COG1028	Short-chain dehydrogenase reductase Sdr
B224_1103	COG0616	signal peptide processing
B224_1104	COG3724	N-succinylarginine dihydrolase activity
B224_1107	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B224_1111	COG0840	transmembrane signaling receptor activity
B224_1114	COG2971	BadF BadG BcrA BcrD
B224_1117	COG4608	Belongs to the ABC transporter superfamily
B224_1119	COG0444	Belongs to the ABC transporter superfamily
B224_1120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_1125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_1126	COG1073	alpha beta
B224_1126	COG3064	Membrane
B224_1126	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B224_1129	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_1133	COG3385	transposase activity
B224_1137	COG3385	transposase activity
B224_1138	COG3385	transposase activity
B224_1140	COG3039	Transposase
B224_1142	COG3039	Transposase
B224_1145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B224_1148	COG1136	(ABC) transporter
B224_1157	COG3039	Transposase
B224_1162	COG3385	transposase activity
B224_1164	COG0643	Histidine kinase
B224_1164	COG2198	Histidine kinase
B224_1166	COG2201	protein-glutamate methylesterase activity
B224_1168	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B224_1169	COG1360	Flagellar Motor Protein
B224_1170	COG1192	Involved in chromosome partitioning
B224_1173	COG0835	chemotaxis
B224_1176	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_1178	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_1180	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_1181	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B224_1182	COG1138	Cytochrome C-type biogenesis protein
B224_1184	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_1185	COG4235	cytochrome complex assembly
B224_1185	COG3088	subunit of a heme lyase
B224_1191	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B224_1193	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_1193	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_1198	COG0259	pyridoxamine-phosphate oxidase activity
B224_1214	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B224_1216	COG1763	Mo-molybdopterin cofactor biosynthetic process
B224_1217	COG0746	molybdenum cofactor guanylyltransferase activity
B224_1218	COG0281	malic enzyme
B224_1230	COG5433	transposase activity
B224_1231	COG5433	transposase activity
B224_1233	COG1129	ABC transporter
B224_1236	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_1238	COG1472	Belongs to the glycosyl hydrolase 3 family
B224_1244	COG1196	nuclear chromosome segregation
B224_1244	COG3264	Mechanosensitive ion channel
B224_1246	COG0469	pyruvate kinase activity
B224_1247	COG2850	peptidyl-arginine hydroxylation
B224_1248	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B224_1249	COG2915	High frequency lysogenization protein hflD homolog
B224_1251	COG0482	sulfurtransferase activity
B224_1255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_1261	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_1261	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_1261	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_1266	COG4932	domain protein
B224_1266	COG5492	domain, Protein
B224_1269	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_1274	COG1482	cell wall glycoprotein biosynthetic process
B224_1275	COG2207	Transcriptional regulator
B224_1276	COG0538	isocitrate dehydrogenase activity
B224_1280	COG3385	transposase activity
B224_1283	COG3048	D-serine ammonia-lyase activity
B224_1284	COG2610	gluconate transmembrane transporter activity
B224_1285	COG0583	DNA-binding transcription factor activity
B224_1286	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_1287	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_1288	COG2375	cellular response to nickel ion
B224_1291	COG0577	efflux transmembrane transporter activity
B224_1291	COG1136	(ABC) transporter
B224_1294	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_1296	COG1227	inorganic diphosphatase activity
B224_1297	COG0497	DNA recombination
B224_1300	COG3706	GGDEF domain
B224_1302	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B224_1303	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B224_1305	COG0443	Heat shock 70 kDa protein
B224_1307	COG0484	heat shock protein binding
B224_1317	COG1285	pathogenesis
B224_1321	COG0640	Transcriptional regulator
B224_1323	COG2391	methyltransferase activity
B224_1332	COG0095	Lipoate-protein ligase
B224_1336	COG0675	Transposase, IS605 OrfB family
B224_1339	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_1343	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_1346	COG0708	Exodeoxyribonuclease III
B224_1352	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_1361	COG0583	DNA-binding transcription factor activity
B224_1362	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_1364	COG5433	transposase activity
B224_1365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B224_1368	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B224_1370	COG1845	cytochrome c oxidase, subunit III
B224_1371	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B224_1372	COG0109	protoheme IX farnesyltransferase activity
B224_1375	COG2814	Major facilitator Superfamily
B224_1377	COG5507	3-demethylubiquinone-9 3-methyltransferase
B224_1387	COG3550	peptidyl-serine autophosphorylation
B224_1388	COG1396	sequence-specific DNA binding
B224_1389	COG5433	transposase activity
B224_1401	COG3385	transposase activity
B224_1405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B224_1409	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_1410	COG3039	Transposase
B224_1411	COG2271	Major facilitator Superfamily
B224_1415	COG1566	PFAM secretion protein HlyD family protein
B224_1421	COG2373	Large extracellular alpha-helical protein
B224_1422	COG4953	penicillin-binding protein 1C
B224_1425	COG0301	tRNA thio-modification
B224_1425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_1434	COG5433	transposase activity
B224_1436	COG3039	Transposase
B224_1440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_1443	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B224_1447	COG0346	lactoylglutathione lyase activity
B224_1448	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B224_1451	COG4659	FMN binding
B224_1454	COG4658	electron transport chain
B224_1457	COG4656	Part of a membrane complex involved in electron transport
B224_1458	COG2878	Part of a membrane complex involved in electron transport
B224_1459	COG4657	Part of a membrane complex involved in electron transport
B224_1460	COG0697	spore germination
B224_1466	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B224_1467	COG1288	antiporter activity
B224_1468	COG0436	Aminotransferase
B224_1471	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B224_1473	COG2027	D-alanyl-D-alanine carboxypeptidase
B224_1474	COG1061	Type III restriction enzyme res subunit
B224_1476	COG1566	PFAM secretion protein HlyD family protein
B224_1478	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B224_1478	COG3264	Mechanosensitive ion channel
B224_1479	COG1966	Carbon starvation protein
B224_1481	COG3279	Response regulator of the LytR AlgR family
B224_1482	COG3275	phosphorelay sensor kinase activity
B224_1485	COG1454	alcohol dehydrogenase
B224_1485	COG1012	belongs to the aldehyde dehydrogenase family
B224_1488	COG2095	MarC family integral membrane protein
B224_1491	COG0601	transmembrane transport
B224_1492	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_1493	COG0444	Belongs to the ABC transporter superfamily
B224_1495	COG0861	Integral membrane protein TerC family
B224_1498	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B224_1499	COG3385	transposase activity
B224_1501	COG1301	dicarboxylic acid transport
B224_1505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B224_1510	COG0537	adenosine 5'-monophosphoramidase activity
B224_1519	COG0675	Transposase, IS605 OrfB family
B224_1521	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_1524	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_1527	COG2354	Protein conserved in bacteria
B224_1535	COG1252	NADH dehydrogenase
B224_1538	COG0393	Putative heavy-metal-binding
B224_1540	COG1619	proteins homologs of microcin C7 resistance protein MccF
B224_1542	COG1619	proteins homologs of microcin C7 resistance protein MccF
B224_1544	COG1368	sulfuric ester hydrolase activity
B224_1547	COG0527	aspartate kinase activity
B224_1549	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B224_1549	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B224_1551	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B224_1554	COG2315	Protein conserved in bacteria
B224_1556	COG0583	DNA-binding transcription factor activity
B224_1557	COG1620	l-lactate permease
B224_1559	COG0247	lactate metabolic process
B224_1560	COG1139	Iron-sulfur cluster binding protein
B224_1564	COG3039	Transposase
B224_1569	COG1136	(ABC) transporter
B224_1575	COG2814	Major facilitator Superfamily
B224_1585	COG0672	)-iron permease
B224_1595	COG2308	Evidence 4 Homologs of previously reported genes of
B224_1601	COG0582	viral genome integration into host DNA
B224_1609	COG0659	secondary active sulfate transmembrane transporter activity
B224_1611	COG3039	Transposase
B224_1612	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B224_1614	COG0326	Molecular chaperone. Has ATPase activity
B224_1617	COG0563	adenylate kinase activity
B224_1619	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B224_1621	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_1623	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B224_1625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_1628	COG0840	transmembrane signaling receptor activity
B224_1633	COG3300	MHYT domain
B224_1633	COG5001	Diguanylate cyclase
B224_1635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B224_1642	COG1021	2,3-dihydroxybenzoate-AMP ligase
B224_1644	COG3433	isochorismatase activity
B224_1644	COG1535	isochorismatase
B224_1647	COG3385	transposase activity
B224_1648	COG1535	isochorismatase
B224_1648	COG3433	isochorismatase activity
B224_1649	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B224_1651	COG1028	Short-chain dehydrogenase reductase Sdr
B224_1657	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B224_1660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_1661	COG2977	Belongs to the P-Pant transferase superfamily
B224_1662	COG1120	ATPase activity
B224_1664	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_1665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_1666	COG4771	TonB-dependent receptor
B224_1673	COG0598	Magnesium transport protein CorA
B224_1678	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B224_1679	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B224_1681	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_1682	COG0861	Integral membrane protein TerC family
B224_1686	COG1022	Amp-dependent synthetase and ligase
B224_1688	COG0295	cytidine deaminase activity
B224_1689	COG1346	cytolysis
B224_1690	COG1380	Effector of murein hydrolase LrgA
B224_1691	COG3345	alpha-galactosidase
B224_1695	COG2925	Exonuclease
B224_1696	COG0582	viral genome integration into host DNA
B224_1709	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_1716	COG3646	Phage regulatory protein
B224_1724	COG4220	transposase activity
B224_1728	COG0740	serine-type endopeptidase activity
B224_1754	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B224_1754	COG0392	lysyltransferase activity
B224_1757	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_1762	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_1764	COG0436	Aminotransferase
B224_1765	COG0583	DNA-binding transcription factor activity
B224_1767	COG2160	L-arabinose isomerase activity
B224_1770	COG1069	ribulokinase activity
B224_1771	COG1879	ABC-type sugar transport system periplasmic component
B224_1772	COG1129	ABC transporter
B224_1774	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_1777	COG3366	ferrous iron transmembrane transporter activity
B224_1778	COG0700	Nucleoside recognition
B224_1779	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B224_1784	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_1786	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B224_1787	COG0254	rRNA binding
B224_1790	COG1451	nucleotide metabolic process
B224_1795	COG3069	C4-dicarboxylate transmembrane transporter activity
B224_1798	COG4584	PFAM Integrase catalytic
B224_1799	COG1484	DNA-dependent DNA replication
B224_1802	COG3385	transposase activity
B224_1804	COG3385	transposase activity
B224_1810	COG5433	transposase activity
B224_1811	COG3039	Transposase
B224_1813	COG3039	Transposase
B224_1814	COG5433	transposase activity
B224_1818	COG5433	transposase activity
B224_1825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B224_1827	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
B224_1829	COG0724	RNA recognition motif
B224_1830	COG4989	oxidoreductase activity
B224_1836	COG3437	response regulator, receiver
B224_1838	COG0583	DNA-binding transcription factor activity
B224_1840	COG5001	Diguanylate cyclase
B224_1840	COG3300	MHYT domain
B224_1844	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B224_1846	COG0778	Nitroreductase
B224_1853	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B224_1854	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B224_1855	COG0539	negative regulation of cytoplasmic translation
B224_1857	COG0776	regulation of translation
B224_1859	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B224_1863	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B224_1865	COG0602	queuosine metabolic process
B224_1866	COG3530	Putative quorum-sensing-regulated virulence factor
B224_1867	COG2096	Adenosyltransferase
B224_1869	COG5433	transposase activity
B224_1872	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_1873	COG1757	Na H antiporter
B224_1875	COG1435	thymidine kinase activity
B224_1890	COG2226	methyltransferase
B224_1893	COG3550	peptidyl-serine autophosphorylation
B224_1900	COG5433	transposase activity
B224_1918	COG5433	transposase activity
B224_1919	COG3039	Transposase
B224_1921	COG5433	transposase activity
B224_1925	COG0629	single-stranded DNA binding
B224_1926	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B224_1927	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_1930	COG1484	DNA-dependent DNA replication
B224_1947	COG1104	cysteine desulfurase activity
B224_1955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B224_1958	COG0626	cystathionine gamma-synthase activity
B224_1961	COG2910	NAD(P)H-binding
B224_1962	COG0583	DNA-binding transcription factor activity
B224_1966	COG2207	Transcriptional regulator
B224_1966	COG3708	Transcriptional regulator
B224_1968	COG4774	siderophore transport
B224_1971	COG0583	DNA-binding transcription factor activity
B224_1972	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B224_1981	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_1984	COG3046	protein related to deoxyribodipyrimidine photolyase
B224_1986	COG3088	subunit of a heme lyase
B224_1986	COG4235	cytochrome complex assembly
B224_1987	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_1989	COG1138	Cytochrome C-type biogenesis protein
B224_1991	COG3301	Polysulphide reductase, NrfD
B224_1992	COG0437	4 iron, 4 sulfur cluster binding
B224_1993	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B224_2003	COG0247	lactate metabolic process
B224_2005	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
B224_2007	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B224_2008	COG3012	SEC-C Motif Domain Protein
B224_2011	COG1846	Transcriptional regulator
B224_2011	COG1940	carbohydrate kinase activity
B224_2013	COG3290	protein histidine kinase activity
B224_2014	COG4565	transcriptional regulatory protein
B224_2022	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B224_2024	COG2985	domain, Protein
B224_2024	COG0569	domain protein
B224_2027	COG0556	nucleotide-excision repair
B224_2029	COG0586	Pfam SNARE associated Golgi protein
B224_2030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B224_2031	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B224_2033	COG2719	SpoVR family
B224_2034	COG2718	Belongs to the UPF0229 family
B224_2036	COG2766	serine protein kinase
B224_2039	COG0514	ATP-dependent DNA helicase (RecQ)
B224_2040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B224_2042	COG0814	amino acid
B224_2043	COG5433	transposase activity
B224_2054	COG0058	SHG alpha-glucan phosphorylase activity
B224_2057	COG0471	metal ion transport
B224_2060	COG3118	belongs to the thioredoxin family
B224_2064	COG1132	(ABC) transporter
B224_2066	COG1132	(ABC) transporter
B224_2071	COG5433	transposase activity
B224_2075	COG2501	S4 domain
B224_2083	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B224_2084	COG2329	Antibiotic biosynthesis monooxygenase
B224_2087	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B224_2088	COG0673	inositol 2-dehydrogenase activity
B224_2089	COG0583	DNA-binding transcription factor activity
B224_2092	COG1560	Kdo2-lipid A biosynthetic process
B224_2094	COG1560	Kdo2-lipid A biosynthetic process
B224_2101	COG0417	DNA replication proofreading
B224_2105	COG0307	riboflavin synthase, alpha
B224_2106	COG0675	Transposase, IS605 OrfB family
B224_2109	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_2110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B224_2111	COG0697	spore germination
B224_2112	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B224_2125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B224_2127	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B224_2128	COG2894	cell division
B224_2129	COG0850	regulation of cytokinetic process
B224_2130	COG3100	YcgL domain-containing protein
B224_2131	COG2951	lytic endotransglycosylase activity
B224_2133	COG1760	l-serine dehydratase
B224_2135	COG1760	l-serine dehydratase
B224_2137	COG3123	guanosine phosphorylase activity
B224_2138	COG1301	dicarboxylic acid transport
B224_2143	COG2067	long-chain fatty acid transport protein
B224_2146	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B224_2147	COG2067	long-chain fatty acid transport protein
B224_2148	COG2067	long-chain fatty acid transport protein
B224_2159	COG0714	Associated with various cellular activities
B224_2160	COG0183	Belongs to the thiolase family
B224_2161	COG1250	3-hydroxyacyl-CoA dehydrogenase
B224_2161	COG1024	Enoyl-CoA hydratase
B224_2165	COG4681	YaeQ
B224_2171	COG4372	Transposase
B224_2175	COG3328	transposase activity
B224_2182	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_2188	COG3134	Outer membrane lipoprotein
B224_2189	COG0318	PFAM AMP-dependent synthetase and ligase
B224_2190	COG2378	regulation of single-species biofilm formation
B224_2193	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B224_2193	COG0140	phosphoribosyl-ATP diphosphatase activity
B224_2194	COG0107	imidazoleglycerol-phosphate synthase activity
B224_2196	COG0784	Response regulator, receiver
B224_2196	COG2205	protein histidine kinase activity
B224_2196	COG2198	Histidine kinase
B224_2199	COG3437	response regulator, receiver
B224_2201	COG5433	transposase activity
B224_2205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B224_2206	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B224_2207	COG0131	Imidazoleglycerol-phosphate dehydratase
B224_2207	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B224_2209	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B224_2210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B224_2211	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B224_2214	COG1199	ATP-dependent helicase activity
B224_2215	COG1214	PFAM Peptidase M22, glycoprotease
B224_2218	COG0596	Alpha beta hydrolase
B224_2220	COG0318	PFAM AMP-dependent synthetase and ligase
B224_2221	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B224_2223	COG0697	spore germination
B224_2228	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_2229	COG2832	Protein of unknown function (DUF454)
B224_2230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B224_2234	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B224_2235	COG1335	isochorismatase
B224_2245	COG1643	Atp-dependent helicase
B224_2247	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B224_2252	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B224_2253	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B224_2254	COG0709	Synthesizes selenophosphate from selenide and ATP
B224_2256	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B224_2258	COG0840	transmembrane signaling receptor activity
B224_2260	COG1254	Belongs to the acylphosphatase family
B224_2263	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_2263	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_2264	COG0489	protein tyrosine kinase activity
B224_2265	COG0572	uridine kinase
B224_2266	COG0717	Belongs to the dCTP deaminase family
B224_2268	COG0306	phosphate transporter
B224_2270	COG4584	PFAM Integrase catalytic
B224_2274	COG1484	DNA-dependent DNA replication
B224_2278	COG1530	ribonuclease E activity
B224_2279	COG0564	pseudouridine synthase activity
B224_2280	COG0546	phosphoglycolate phosphatase activity
B224_2281	COG0424	maF-like protein
B224_2283	COG1399	metal-binding, possibly nucleic acid-binding protein
B224_2285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B224_2286	COG0416	fatty acid biosynthetic process
B224_2287	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B224_2290	COG1028	Short-chain dehydrogenase reductase Sdr
B224_2291	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B224_2295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B224_2296	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B224_2297	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B224_2299	COG0470	DNA polymerase III
B224_2300	COG0084	hydrolase, TatD family'
B224_2304	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_2304	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B224_2306	COG3008	intermembrane lipid transfer
B224_2308	COG2995	paraquat-inducible protein a
B224_2311	COG3141	response to X-ray
B224_2314	COG1067	ATP-dependent peptidase activity
B224_2315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B224_2318	COG0488	(ABC) transporter
B224_2320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B224_2320	COG0116	Belongs to the methyltransferase superfamily
B224_2322	COG0167	dihydroorotate dehydrogenase activity
B224_2325	COG2902	Dehydrogenase
B224_2327	COG0308	aminopeptidase N
B224_2330	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B224_2331	COG1956	GAF domain-containing protein
B224_2333	COG3278	Belongs to the heme-copper respiratory oxidase family
B224_2337	COG2010	Cytochrome c
B224_2343	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B224_2344	COG0589	response to stress
B224_2345	COG0037	tRNA processing
B224_2348	COG0625	glutathione transferase activity
B224_2349	COG1869	D-ribose catabolic process
B224_2351	COG1129	ABC transporter
B224_2352	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_2353	COG1879	ABC-type sugar transport system periplasmic component
B224_2354	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_2355	COG1609	Transcriptional regulator
B224_2357	COG3300	MHYT domain
B224_2357	COG5001	Diguanylate cyclase
B224_2359	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B224_2365	COG0784	Response regulator, receiver
B224_2365	COG2205	protein histidine kinase activity
B224_2366	COG0776	regulation of translation
B224_2368	COG0072	phenylalanine-tRNA ligase activity
B224_2368	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_2369	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B224_2371	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B224_2372	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B224_2373	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B224_2374	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B224_2382	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B224_2385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B224_2388	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_2390	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B224_2391	COG3313	Fe-S protein
B224_2394	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B224_2394	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_2394	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_2395	COG1105	Belongs to the carbohydrate kinase PfkB family
B224_2397	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_2397	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_2399	COG1609	Transcriptional regulator
B224_2400	COG0814	amino acid
B224_2401	COG3788	relative of glutathione S-transferase, MAPEG superfamily
B224_2403	COG0513	Belongs to the DEAD box helicase family
B224_2405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B224_2406	COG2890	protein-(glutamine-N5) methyltransferase activity
B224_2407	COG2840	Smr protein MutS2
B224_2409	COG0406	alpha-ribazole phosphatase activity
B224_2418	COG2824	Alkylphosphonate utilization operon protein PhnA
B224_2431	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B224_2433	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B224_2436	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B224_2437	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B224_2440	COG0205	6-phosphofructokinase activity
B224_2443	COG1473	amidohydrolase
B224_2444	COG1011	Hydrolase
B224_2445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_2448	COG3593	DNA synthesis involved in DNA repair
B224_2452	COG0583	DNA-binding transcription factor activity
B224_2453	COG0730	response to heat
B224_2456	COG1181	Belongs to the D-alanine--D-alanine ligase family
B224_2458	COG0386	Belongs to the glutathione peroxidase family
B224_2459	COG0513	Belongs to the DEAD box helicase family
B224_2463	COG1742	UPF0060 membrane protein
B224_2471	COG3039	Transposase
B224_2476	COG0583	DNA-binding transcription factor activity
B224_2478	COG1028	Short-chain dehydrogenase reductase Sdr
B224_2481	COG2723	6-phospho-beta-galactosidase activity
B224_2482	COG0583	DNA-binding transcription factor activity
B224_2484	COG3706	GGDEF domain
B224_2488	COG0243	molybdopterin cofactor binding
B224_2489	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B224_2493	COG0583	DNA-binding transcription factor activity
B224_2495	COG1879	ABC-type sugar transport system periplasmic component
B224_2498	COG1879	ABC-type sugar transport system periplasmic component
B224_2499	COG1129	ABC transporter
B224_2501	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_2503	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_2505	COG3039	Transposase
B224_2509	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B224_2513	COG2003	Belongs to the UPF0758 family
B224_2520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B224_2523	COG0730	response to heat
B224_2527	COG1028	Short-chain dehydrogenase reductase Sdr
B224_2531	COG1024	Enoyl-CoA hydratase
B224_2533	COG1024	Enoyl-CoA hydratase
B224_2534	COG1960	acyl-CoA dehydrogenase activity
B224_2537	COG1960	acyl-CoA dehydrogenase activity
B224_2538	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B224_2539	COG1024	Enoyl-CoA hydratase
B224_2548	COG1584	GPR1 FUN34 yaaH family protein
B224_2551	COG1115	amino acid carrier protein
B224_2553	COG1024	Enoyl-CoA hydratase
B224_2558	COG3162	membrane
B224_2560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B224_2562	COG0488	(ABC) transporter
B224_2564	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B224_2565	COG0776	regulation of translation
B224_2567	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B224_2568	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B224_2569	COG0740	serine-type endopeptidase activity
B224_2571	COG0544	peptidyl-prolyl cis-trans isomerase activity
B224_2576	COG4591	ABC-type transport system involved in lipoprotein release permease component
B224_2577	COG1136	(ABC) transporter
B224_2578	COG4591	ABC-type transport system involved in lipoprotein release permease component
B224_2583	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B224_2586	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B224_2588	COG4166	transmembrane transport
B224_2589	COG0697	spore germination
B224_2591	COG2062	phosphohistidine phosphatase, SixA
B224_2596	COG3039	Transposase
B224_2598	COG3039	Transposase
B224_2600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B224_2600	COG0519	Catalyzes the synthesis of GMP from XMP
B224_2602	COG0516	GMP reductase activity
B224_2602	COG0517	IMP dehydrogenase activity
B224_2611	COG1874	Beta-galactosidase
B224_2611	COG0366	Alpha amylase catalytic
B224_2615	COG1570	exodeoxyribonuclease VII activity
B224_2620	COG2885	chlorophyll binding
B224_2621	COG2199	diguanylate cyclase activity
B224_2627	COG2154	pterin-4-alpha-carbinolamine dehydratase
B224_2630	COG3768	UPF0283 membrane protein
B224_2633	COG3106	COG3106 Predicted ATPase
B224_2637	COG1842	Phage shock protein A
B224_2638	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B224_2641	COG4168	peptide transport system, permease
B224_2642	COG4171	peptide transport system, permease
B224_2646	COG4172	Belongs to the ABC transporter superfamily
B224_2649	COG1609	Transcriptional regulator
B224_2650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_2650	COG1263	PTS System
B224_2653	COG2723	6-phospho-beta-galactosidase activity
B224_2654	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B224_2655	COG1286	toxin biosynthetic process
B224_2658	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B224_2660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B224_2661	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B224_2663	COG1674	ftsk spoiiie
B224_2663	COG0531	amino acid
B224_2665	COG0686	Belongs to the AlaDH PNT family
B224_2667	COG0492	ferredoxin-NADP+ reductase activity
B224_2668	COG3706	GGDEF domain
B224_2669	COG3134	Outer membrane lipoprotein
B224_2670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B224_2671	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B224_2672	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B224_2673	COG0542	response to heat
B224_2674	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B224_2675	COG1278	Cold shock
B224_2676	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B224_2679	COG2076	Multidrug Resistance protein
B224_2682	COG1944	ATP diphosphatase activity
B224_2684	COG2116	formate transmembrane transporter activity
B224_2686	COG1882	Formate acetyltransferase
B224_2688	COG2983	Belongs to the UPF0260 family
B224_2691	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B224_2693	COG0045	succinate-CoA ligase (ADP-forming) activity
B224_2695	COG0508	dehydrogenase complex catalyzes the overall conversion of
B224_2698	COG0567	Dehydrogenase, E1 component
B224_2699	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B224_2700	COG1053	succinate dehydrogenase
B224_2702	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B224_2703	COG2009	succinate dehydrogenase
B224_2710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B224_2711	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_2711	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B224_2717	COG5433	transposase activity
B224_2721	COG3385	transposase activity
B224_2724	COG1484	DNA-dependent DNA replication
B224_2725	COG4584	PFAM Integrase catalytic
B224_2728	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B224_2729	COG1360	Flagellar Motor Protein
B224_2733	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_2734	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_2737	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_2737	COG0649	NAD binding
B224_2741	COG1034	ATP synthesis coupled electron transport
B224_2744	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B224_2745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_2746	COG0839	Belongs to the complex I subunit 6 family
B224_2747	COG0713	ATP synthesis coupled electron transport
B224_2749	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_2751	COG1007	ATP synthesis coupled electron transport
B224_2753	COG0047	phosphoribosylformylglycinamidine synthase activity
B224_2753	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B224_2756	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B224_2760	COG1160	GTP binding
B224_2762	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_2764	COG2976	Protein conserved in bacteria
B224_2765	COG0124	histidyl-tRNA synthetase
B224_2773	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B224_2774	COG0105	UTP biosynthetic process
B224_2775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_2778	COG0633	Ferredoxin
B224_2780	COG0443	Heat shock 70 kDa protein
B224_2781	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B224_2784	COG0822	iron-sulfur transferase activity
B224_2785	COG1104	cysteine desulfurase activity
B224_2796	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_2798	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_2799	COG1862	Preprotein translocase
B224_2801	COG0343	queuine tRNA-ribosyltransferase activity
B224_2803	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B224_2805	COG0517	IMP dehydrogenase activity
B224_2807	COG0450	alkyl hydroperoxide reductase
B224_2809	COG3634	alkyl hydroperoxide reductase activity
B224_2811	COG2814	Major facilitator Superfamily
B224_2816	COG2351	hydroxyisourate hydrolase activity
B224_2829	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B224_2829	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B224_2830	COG0509	glycine decarboxylation via glycine cleavage system
B224_2831	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B224_2832	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_2834	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_2837	COG2814	Major facilitator Superfamily
B224_2841	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_2842	COG0601	transmembrane transport
B224_2845	COG0625	glutathione transferase activity
B224_2850	COG0483	inositol monophosphate 1-phosphatase activity
B224_2857	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B224_2859	COG2056	Na+-H+ antiporter family
B224_2862	COG2814	Major facilitator Superfamily
B224_2863	COG0583	DNA-binding transcription factor activity
B224_2866	COG0513	Belongs to the DEAD box helicase family
B224_2867	COG2050	protein possibly involved in aromatic compounds catabolism
B224_2871	COG0277	FAD linked oxidase domain protein
B224_2871	COG0247	lactate metabolic process
B224_2873	COG1253	flavin adenine dinucleotide binding
B224_2876	COG1902	pentaerythritol trinitrate reductase activity
B224_2877	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B224_2878	COG0647	UMP catabolic process
B224_2880	COG0367	asparagine synthase
B224_2883	COG0625	glutathione transferase activity
B224_2885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B224_2889	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B224_2893	COG0564	pseudouridine synthase activity
B224_2896	COG3706	GGDEF domain
B224_2899	COG0840	transmembrane signaling receptor activity
B224_2901	COG0318	PFAM AMP-dependent synthetase and ligase
B224_2907	COG4447	cellulose binding
B224_2914	COG2855	membrane
B224_2917	COG2814	Major facilitator Superfamily
B224_2921	COG3246	L-lysine catabolic process to acetate
B224_2922	COG2175	clavaminate synthase activity
B224_2925	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B224_2933	COG0670	Belongs to the BI1 family
B224_2935	COG1289	transmembrane transporter activity
B224_2937	COG2920	part of a sulfur-relay system
B224_2938	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B224_2940	COG0285	dihydrofolate synthase activity
B224_2941	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B224_2942	COG0101	tRNA pseudouridine synthase activity
B224_2946	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B224_2948	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B224_2950	COG0671	phosphoesterase, PA-phosphatase related
B224_2951	COG1464	Belongs to the NlpA lipoprotein family
B224_2952	COG3039	Transposase
B224_2956	COG1119	ATPase activity
B224_2957	COG1484	DNA-dependent DNA replication
B224_2958	COG4584	PFAM Integrase catalytic
B224_2959	COG2801	Transposase and inactivated derivatives
B224_2961	COG1119	ATPase activity
B224_2963	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B224_2963	COG0574	Belongs to the PEP-utilizing enzyme family
B224_2964	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B224_2967	COG1113	amino acid transport
B224_2982	COG1242	4 iron, 4 sulfur cluster binding
B224_2985	COG0069	glutamate synthase activity
B224_2985	COG0070	glutamate synthase
B224_2985	COG0067	glutamate synthase
B224_2986	COG0493	'glutamate synthase
B224_2989	COG0789	Transcriptional regulator
B224_2992	COG4104	PAAR repeat-containing protein
B224_2997	COG0513	Belongs to the DEAD box helicase family
B224_3007	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B224_3009	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B224_3011	COG0505	Belongs to the CarA family
B224_3013	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B224_3017	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B224_3018	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B224_3019	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B224_3020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B224_3021	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_3022	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
B224_3037	COG0023	Translation Initiation Factor
B224_3038	COG2119	membrane
B224_3048	COG2199	diguanylate cyclase activity
B224_3048	COG2203	Gaf domain
B224_3051	COG5433	transposase activity
B224_3052	COG3039	Transposase
B224_3054	COG5433	transposase activity
B224_3064	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B224_3066	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_3067	COG2261	transglycosylase associated protein
B224_3068	COG0625	glutathione transferase activity
B224_3074	COG5433	transposase activity
B224_3081	COG0322	excinuclease ABC activity
B224_3082	COG2197	response regulator
B224_3084	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B224_3085	COG2835	tetraacyldisaccharide 4'-kinase activity
B224_3087	COG1663	tetraacyldisaccharide 4'-kinase activity
B224_3088	COG1132	(ABC) transporter
B224_3089	COG2333	competence protein COMEC
B224_3089	COG0658	competence protein
B224_3098	COG2731	YhcH YjgK YiaL family protein
B224_3102	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_3103	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_3110	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_3112	COG0443	Heat shock 70 kDa protein
B224_3115	COG2801	Transposase and inactivated derivatives
B224_3116	COG4584	PFAM Integrase catalytic
B224_3121	COG1484	DNA-dependent DNA replication
B224_3129	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B224_3142	COG0675	Transposase, IS605 OrfB family
B224_3156	COG3385	transposase activity
B224_3161	COG2333	competence protein COMEC
B224_3161	COG0658	competence protein
B224_3169	COG0433	COG0433 Predicted ATPase
B224_3173	COG1448	Aminotransferase
B224_3176	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B224_3179	COG1199	ATP-dependent helicase activity
B224_3181	COG0123	including yeast histone deacetylase and acetoin utilization protein
B224_3182	COG0477	Major facilitator Superfamily
B224_3183	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B224_3185	COG1785	Belongs to the alkaline phosphatase family
B224_3192	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B224_3193	COG2197	response regulator
B224_3195	COG2271	Major facilitator Superfamily
B224_3198	COG0675	Transposase, IS605 OrfB family
B224_3200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_3201	COG0765	amino acid transport
B224_3202	COG1126	abc transporter atp-binding protein
B224_3205	COG3385	transposase activity
B224_3208	COG0531	amino acid
B224_3212	COG1253	flavin adenine dinucleotide binding
B224_3213	COG0704	Plays a role in the regulation of phosphate uptake
B224_3216	COG0581	inorganic phosphate transmembrane transporter activity
B224_3219	COG0573	inorganic phosphate transmembrane transporter activity
B224_3221	COG0590	tRNA wobble adenosine to inosine editing
B224_3223	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B224_3229	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B224_3230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B224_3231	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B224_3232	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B224_3234	COG2204	response regulator
B224_3236	COG3852	Histidine kinase
B224_3237	COG2204	response regulator
B224_3240	COG2716	regulation of RNA biosynthetic process
B224_3242	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B224_3244	COG0248	Ppx GppA phosphatase
B224_3246	COG2239	Acts as a magnesium transporter
B224_3247	COG0675	Transposase, IS605 OrfB family
B224_3248	COG2239	Acts as a magnesium transporter
B224_3254	COG3951	Flagellar rod assembly protein muramidase FlgJ
B224_3254	COG1705	Flagellar rod assembly protein muramidase FlgJ
B224_3257	COG1706	bacterial-type flagellum-dependent cell motility
B224_3258	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B224_3259	COG4786	Flagellar basal body rod
B224_3263	COG1558	bacterial-type flagellum-dependent cell motility
B224_3264	COG1815	bacterial-type flagellum-dependent cell motility
B224_3265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B224_3266	COG0835	chemotaxis
B224_3266	COG0784	Response regulator, receiver
B224_3267	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B224_3271	COG0622	Phosphoesterase
B224_3273	COG4166	transmembrane transport
B224_3275	COG1187	pseudouridine synthase activity
B224_3277	COG0675	Transposase, IS605 OrfB family
B224_3280	COG0697	spore germination
B224_3287	COG1278	Cold shock
B224_3299	COG3132	Protein of unknown function, DUF480
B224_3303	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_3307	COG2801	Transposase and inactivated derivatives
B224_3310	COG3206	protein involved in exopolysaccharide biosynthesis
B224_3310	COG0489	protein tyrosine kinase activity
B224_3311	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B224_3319	COG3039	Transposase
B224_3325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B224_3326	COG3385	transposase activity
B224_3329	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B224_3331	COG1091	dTDP-4-dehydrorhamnose reductase activity
B224_3334	COG0745	RESPONSE REGULATOR receiver
B224_3338	COG1737	Transcriptional regulator
B224_3339	COG0469	pyruvate kinase activity
B224_3343	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_3345	COG1960	acyl-CoA dehydrogenase activity
B224_3348	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B224_3350	COG3039	Transposase
B224_3351	COG5433	transposase activity
B224_3355	COG1484	DNA-dependent DNA replication
B224_3356	COG4584	PFAM Integrase catalytic
B224_3359	COG1538	Outer membrane efflux protein
B224_3362	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_3363	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_3366	COG1309	transcriptional regulator
B224_3370	COG1946	Acyl-CoA thioesterase
B224_3372	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B224_3374	COG0009	L-threonylcarbamoyladenylate synthase
B224_3377	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B224_3378	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B224_3378	COG0512	Glutamine amidotransferase of anthranilate synthase
B224_3380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B224_3381	COG0134	indole-3-glycerol-phosphate synthase activity
B224_3381	COG0135	phosphoribosylanthranilate isomerase activity
B224_3383	COG0133	tryptophan synthase activity
B224_3384	COG0159	tryptophan synthase activity
B224_3394	COG0438	transferase activity, transferring glycosyl groups
B224_3394	COG1216	Glycosyl transferase, family 2
B224_3396	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B224_3398	COG1091	dTDP-4-dehydrorhamnose reductase activity
B224_3405	COG4160	amino acid transport
B224_3406	COG4215	(ABC) transporter
B224_3407	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_3411	COG2431	L-lysine efflux transmembrane transporter activity
B224_3414	COG3385	transposase activity
B224_3415	COG0675	Transposase, IS605 OrfB family
B224_3417	COG1393	Belongs to the ArsC family
B224_3420	COG4783	chaperone-mediated protein folding
B224_3427	COG0675	Transposase, IS605 OrfB family
B224_3432	COG3842	ATPase activity
B224_3435	COG1175	transmembrane transport
B224_3437	COG2182	Extracellular solute-binding protein
B224_3438	COG3081	Nucleoid-associated protein
B224_3439	COG3082	Protein of unknown function (DUF1414)
B224_3440	COG3083	sulfuric ester hydrolase activity
B224_3443	COG4206	TonB-dependent receptor
B224_3444	COG1770	oligopeptidase
B224_3452	COG4574	serine-type endopeptidase inhibitor activity
B224_3453	COG3085	chromosome segregation
B224_3456	COG1605	Chorismate mutase
B224_3456	COG0287	Prephenate dehydrogenase
B224_3460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_3461	COG0584	glycerophosphoryl diester phosphodiesterase
B224_3465	COG1349	DNA-binding transcription factor activity
B224_3466	COG2271	Major facilitator Superfamily
B224_3468	COG5433	transposase activity
B224_3470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B224_3473	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B224_3474	COG0583	DNA-binding transcription factor activity
B224_3482	COG0656	L-ascorbic acid biosynthetic process
B224_3484	COG2814	Major facilitator Superfamily
B224_3486	COG1294	oxidase, subunit
B224_3489	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_3492	COG1595	DNA-templated transcription, initiation
B224_3497	COG2979	Protein of unknown function (DUF533)
B224_3511	COG1187	pseudouridine synthase activity
B224_3512	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B224_3519	COG1061	Type III restriction enzyme res subunit
B224_3529	COG1166	arginine decarboxylase activity
B224_3533	COG2195	Cleaves the N-terminal amino acid of tripeptides
B224_3538	COG0675	Transposase, IS605 OrfB family
B224_3544	COG0583	DNA-binding transcription factor activity
B224_3547	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B224_3550	COG0840	transmembrane signaling receptor activity
B224_3551	COG0302	gtp cyclohydrolase
B224_3555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B224_3557	COG0596	Alpha beta hydrolase
B224_3559	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B224_3562	COG0314	molybdopterin synthase activity
B224_3563	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B224_3564	COG0315	cyclic pyranopterin monophosphate synthase activity
B224_3566	COG0521	Mo-molybdopterin cofactor biosynthetic process
B224_3567	COG3005	denitrification pathway
B224_3570	COG0348	domain, Protein
B224_3571	COG0437	4 iron, 4 sulfur cluster binding
B224_3573	COG0243	molybdopterin cofactor binding
B224_3576	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B224_3577	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B224_3579	COG3850	Histidine kinase
B224_3580	COG2197	response regulator
B224_3588	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B224_3590	COG0121	glutamine amidotransferase
B224_3591	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B224_3593	COG1960	acyl-CoA dehydrogenase activity
B224_3595	COG0784	Response regulator, receiver
B224_3595	COG3437	response regulator, receiver
B224_3598	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B224_3600	COG0328	RNA-DNA hybrid ribonuclease activity
B224_3601	COG2226	methyltransferase
B224_3602	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B224_3603	COG1388	LysM domain
B224_3603	COG0741	lytic transglycosylase activity
B224_3607	COG1607	acyl-coa hydrolase
B224_3611	COG0741	lytic transglycosylase activity
B224_3616	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B224_3623	COG0729	surface antigen
B224_3625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B224_3627	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_3631	COG4134	Bacterial extracellular solute-binding protein
B224_3634	COG4136	ATPase activity
B224_3635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B224_3637	COG2951	lytic endotransglycosylase activity
B224_3639	COG1846	Transcriptional regulator
B224_3643	COG0033	Phosphoglucomutase
B224_3644	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B224_3645	COG0596	Alpha beta hydrolase
B224_3648	COG0716	FMN binding
B224_3650	COG0735	belongs to the Fur family
B224_3651	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_3656	COG1263	PTS System
B224_3656	COG2190	(PTS) system
B224_3656	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_3657	COG0363	glucosamine-6-phosphate deaminase activity
B224_3659	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B224_3660	COG1940	carbohydrate kinase activity
B224_3660	COG1846	Transcriptional regulator
B224_3663	COG0217	transcriptional regulatory protein
B224_3665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B224_3666	COG1801	Protein of unknown function DUF72
B224_3667	COG4106	trans-aconitate 2-methyltransferase activity
B224_3668	COG0500	methyltransferase
B224_3673	COG0583	DNA-binding transcription factor activity
B224_3674	COG0791	NLP P60 protein
B224_3678	COG1309	transcriptional regulator
B224_3686	COG0534	Mate efflux family protein
B224_3689	COG2841	Protein conserved in bacteria
B224_3690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B224_3690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B224_3690	COG1013	pyruvate-flavodoxin oxidoreductase activity
B224_3690	COG0674	pyruvate-flavodoxin oxidoreductase activity
B224_3694	COG0633	Ferredoxin
B224_3694	COG3217	Mosc domain protein beta barrel domain protein
B224_3694	COG3217	Mosc domain protein beta barrel domain protein
B224_3694	COG0633	Ferredoxin
B224_3696	COG0501	Belongs to the peptidase M48B family
B224_3697	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B224_3698	COG2226	methyltransferase
B224_3698	COG1073	alpha beta
B224_3699	COG0156	8-amino-7-oxononanoate synthase activity
B224_3702	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B224_3708	COG0017	Asparaginyl-tRNA synthetase
B224_3710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B224_3716	COG1393	Belongs to the ArsC family
B224_3717	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B224_3719	COG1876	peptidase activity
B224_3723	COG3263	regulation of cellular component size
B224_3728	COG1280	lysine exporter protein (LysE YggA)
B224_3734	COG0564	pseudouridine synthase activity
B224_3737	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_3738	COG0702	epimerase
B224_3741	COG2867	negative regulation of translational initiation
B224_3742	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B224_3743	COG0582	viral genome integration into host DNA
B224_3750	COG1598	PFAM Uncharacterised protein family UPF0150
B224_3752	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B224_3758	COG3153	acetyltransferase
B224_3769	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B224_3772	COG0745	RESPONSE REGULATOR receiver
B224_3775	COG4988	ABC transporter
B224_3778	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B224_3782	COG1720	tRNA m6t6A37 methyltransferase activity
B224_3787	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B224_3788	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B224_3789	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_3792	COG2190	(PTS) system
B224_3793	COG3038	cytochrome b561
B224_3798	COG0420	3'-5' exonuclease activity
B224_3799	COG0456	acetyltransferase
B224_3801	COG2974	May be involved in recombination
B224_3804	COG0405	Gamma-glutamyltransferase
B224_3808	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_3809	COG1917	Cupin 2, conserved barrel domain protein
B224_3809	COG1396	sequence-specific DNA binding
B224_3816	COG0531	amino acid
B224_3818	COG0531	amino acid
B224_3821	COG1283	sodium-dependent phosphate transmembrane transporter activity
B224_3824	COG3384	dioxygenase
B224_3827	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_3827	COG2205	protein histidine kinase activity
B224_3847	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_3850	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B224_3855	COG4263	nitrous-oxide reductase activity
B224_3858	COG3901	Regulator of nitric oxide reductase transcription
B224_3858	COG0348	domain, Protein
B224_3861	COG5433	transposase activity
B224_3862	COG3901	Regulator of nitric oxide reductase transcription
B224_3862	COG0348	domain, Protein
B224_3864	COG1376	ErfK ybiS ycfS ynhG family protein
B224_3864	COG1388	LysM domain
B224_3869	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B224_3870	COG0791	NLP P60 protein
B224_3873	COG3118	belongs to the thioredoxin family
B224_3875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B224_3876	COG0788	formyltetrahydrofolate deformylase activity
B224_3885	COG0741	lytic transglycosylase activity
B224_3885	COG1196	nuclear chromosome segregation
B224_3885	COG0739	heme binding
B224_3888	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B224_3889	COG0673	inositol 2-dehydrogenase activity
B224_3898	COG1032	radical SAM domain protein
B224_3900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_3903	COG3706	GGDEF domain
B224_3904	COG1752	Esterase of the alpha-beta hydrolase superfamily
B224_3906	COG0733	neurotransmitter:sodium symporter activity
B224_3918	COG0281	malic enzyme
B224_3921	COG0534	Mate efflux family protein
B224_3925	COG0745	RESPONSE REGULATOR receiver
B224_3925	COG3706	GGDEF domain
B224_3926	COG2233	PERMEase
B224_3928	COG0095	Lipoate-protein ligase
B224_3930	COG1115	amino acid carrier protein
B224_3931	COG0019	diaminopimelate decarboxylase activity
B224_3935	COG0678	peroxiredoxin activity
B224_3936	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B224_3938	COG1126	abc transporter atp-binding protein
B224_3939	COG0765	amino acid transport
B224_3944	COG4597	amino acid ABC transporter
B224_3946	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_3949	COG1131	(ABC) transporter
B224_3950	COG0545	Peptidyl-prolyl cis-trans isomerase
B224_3952	COG3142	Participates in the control of copper homeostasis
B224_3956	COG4783	chaperone-mediated protein folding
B224_3960	COG5002	protein histidine kinase activity
B224_3961	COG0745	RESPONSE REGULATOR receiver
B224_3962	COG0346	lactoylglutathione lyase activity
B224_3964	COG3706	GGDEF domain
B224_3966	COG3284	Transcriptional regulator
B224_3968	COG1012	belongs to the aldehyde dehydrogenase family
B224_3971	COG0697	spore germination
B224_3976	COG3290	protein histidine kinase activity
B224_3977	COG0281	malic enzyme
B224_3981	COG1566	PFAM secretion protein HlyD family protein
B224_3989	COG0602	queuosine metabolic process
B224_3991	COG1328	CTP reductase activity
B224_3995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B224_3996	COG3115	cell septum assembly
B224_3997	COG1196	nuclear chromosome segregation
B224_3999	COG2860	membrane
B224_4003	COG3108	Peptidase M15
B224_4004	COG2989	Protein conserved in bacteria
B224_4009	COG0463	Glycosyl transferase, family 2
B224_4013	COG0366	Alpha amylase catalytic
B224_4025	COG3706	GGDEF domain
B224_4026	COG0037	tRNA processing
B224_4027	COG3590	peptidase
B224_4035	COG0531	amino acid
B224_4036	COG0814	amino acid
B224_4038	COG0583	DNA-binding transcription factor activity
B224_4040	COG3385	transposase activity
B224_4041	COG0825	malonyl-CoA metabolic process
B224_4045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B224_4047	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_4048	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_4049	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B224_4050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_4056	COG0750	zinc metalloprotease
B224_4058	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B224_4059	COG0575	Belongs to the CDS family
B224_4061	COG0233	cytoplasmic translational termination
B224_4062	COG0528	UMP kinase activity
B224_4064	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B224_4065	COG0052	Belongs to the universal ribosomal protein uS2 family
B224_4066	COG0024	Methionine aminopeptidase
B224_4068	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B224_4070	COG2171	N-acyltransferase activity
B224_4073	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_4073	COG1263	PTS System
B224_4077	COG0564	pseudouridine synthase activity
B224_4078	COG3098	single-species biofilm formation
B224_4084	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B224_4087	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B224_4087	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B224_4092	COG3706	GGDEF domain
B224_4093	COG1611	Belongs to the LOG family
B224_4094	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_4096	COG0473	3-isopropylmalate dehydrogenase activity
B224_4098	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B224_4100	COG2363	Small membrane protein
B224_4102	COG0583	DNA-binding transcription factor activity
B224_4104	COG0840	transmembrane signaling receptor activity
B224_4105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B224_4108	COG1477	protein flavinylation
B224_4109	COG2871	sodium ion transport
B224_4112	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_4114	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_4116	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_4117	COG1805	sodium ion transport
B224_4119	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_4121	COG0271	Belongs to the BolA IbaG family
B224_4122	COG2813	Specifically methylates the guanine in position
B224_4125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B224_4128	COG2211	Major facilitator Superfamily
B224_4129	COG3248	Nucleoside-binding outer membrane protein
B224_4131	COG1666	GTP binding
B224_4136	COG3039	Transposase
B224_4144	COG3501	Rhs element vgr protein
B224_4148	COG2771	luxR family
B224_4149	COG0659	secondary active sulfate transmembrane transporter activity
B224_4158	COG1393	Belongs to the ArsC family
B224_4160	COG0798	PFAM Bile acid sodium symporter
B224_4167	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_4168	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_4169	COG1151	hydroxylamine reductase activity
B224_4171	COG0783	Belongs to the Dps family
B224_4178	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B224_4182	COG0300	oxidoreductase activity
B224_4186	COG0789	Transcriptional regulator
B224_4187	COG3272	Protein of unknown function (DUF1722)
B224_4194	COG0077	Prephenate dehydratase
B224_4194	COG1605	Chorismate mutase
B224_4201	COG4580	involved in the transport of maltose and maltodextrins
B224_4202	COG5433	transposase activity
B224_4205	COG5433	transposase activity
B224_4206	COG3385	transposase activity
B224_4207	COG3940	Belongs to the glycosyl hydrolase 43 family
B224_4212	COG1175	transmembrane transport
B224_4222	COG2133	pyrroloquinoline quinone binding
B224_4224	COG1349	DNA-binding transcription factor activity
B224_4225	COG2084	Dehydrogenase
B224_4226	COG3395	kinase activity
B224_4227	COG0235	Class ii aldolase
B224_4228	COG3622	Belongs to the hyi family
B224_4230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B224_4232	COG2610	gluconate transmembrane transporter activity
B224_4237	COG0300	oxidoreductase activity
B224_4242	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B224_4247	COG3813	Protein conserved in bacteria
B224_4249	COG0826	peptidase U32
B224_4252	COG1280	lysine exporter protein (LysE YggA)
B224_4258	COG2203	Gaf domain
B224_4258	COG2200	EAL domain
B224_4258	COG2199	diguanylate cyclase activity
B224_4270	COG0114	fumarate hydratase activity
B224_4276	COG0506	proline dehydrogenase activity
B224_4276	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B224_4276	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B224_4279	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B224_4280	COG0305	Participates in initiation and elongation during chromosome replication
B224_4285	COG0737	Belongs to the 5'-nucleotidase family
B224_4291	COG0545	Peptidyl-prolyl cis-trans isomerase
B224_4293	COG2900	Belongs to the SlyX family
B224_4294	COG1047	Peptidyl-prolyl cis-trans
B224_4296	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B224_4298	COG0835	chemotaxis
B224_4298	COG0784	Response regulator, receiver
B224_4300	COG0429	hydrolase of the alpha beta-hydrolase fold
B224_4301	COG4251	negative regulation of phosphorylation
B224_4301	COG3706	GGDEF domain
B224_4301	COG2203	Gaf domain
B224_4301	COG5001	Diguanylate cyclase
B224_4305	COG3089	Belongs to the UPF0270 family
B224_4306	COG3954	Phosphoribulokinase
B224_4309	COG1765	OsmC-like protein
B224_4310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B224_4318	COG2205	protein histidine kinase activity
B224_4320	COG2814	Major facilitator Superfamily
B224_4324	COG1629	transport
B224_4324	COG4771	TonB-dependent receptor
B224_4334	COG0748	coenzyme F420 binding
B224_4335	COG3721	Heme iron utilization protein
B224_4337	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_4345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B224_4348	COG0463	Glycosyl transferase, family 2
B224_4350	COG0741	lytic transglycosylase activity
B224_4352	COG0488	(ABC) transporter
B224_4355	COG2252	PERMEase
B224_4357	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B224_4359	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B224_4360	COG3178	'Phosphotransferase
B224_4361	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B224_4365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B224_4366	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B224_4368	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B224_4371	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B224_4373	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B224_4377	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B224_4378	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B224_4379	COG0142	geranyltranstransferase activity
B224_4380	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B224_4381	COG0330	HflC and HflK could
B224_4383	COG0330	HflC and HflK could
B224_4384	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B224_4385	COG1923	regulation of RNA biosynthetic process
B224_4387	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B224_4389	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B224_4392	COG0802	atpase or kinase
B224_4393	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B224_4393	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B224_4400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B224_4402	COG2011	ABC-type metal ion transport system permease component
B224_4404	COG1464	Belongs to the NlpA lipoprotein family
B224_4409	COG0840	transmembrane signaling receptor activity
B224_4421	COG3300	MHYT domain
B224_4421	COG5001	Diguanylate cyclase
B224_4423	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B224_4424	COG5002	protein histidine kinase activity
B224_4424	COG2198	Histidine kinase
B224_4424	COG0784	Response regulator, receiver
B224_4436	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B224_4438	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B224_4440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B224_4442	COG2716	regulation of RNA biosynthetic process
B224_4443	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B224_4446	COG3013	Belongs to the UPF0304 family
B224_4448	COG3092	negative regulation of chromosome organization
B224_4449	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B224_4452	COG0857	belongs to the CobB CobQ family
B224_4452	COG0280	phosphate acetyltransferase
B224_4453	COG0440	acetolactate synthase activity
B224_4455	COG0028	Belongs to the TPP enzyme family
B224_4458	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B224_4459	COG0671	phosphoesterase, PA-phosphatase related
B224_4462	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B224_4464	COG0473	3-isopropylmalate dehydrogenase activity
B224_4466	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B224_4467	COG0066	3-isopropylmalate dehydratase activity
B224_4472	COG4143	(ABC) transporter
B224_4475	COG1178	ABC-type Fe3 transport system permease component
B224_4476	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B224_4477	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B224_4482	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B224_4484	COG0564	pseudouridine synthase activity
B224_4488	COG0459	protein refolding
B224_4490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B224_4495	COG3030	protein affecting phage T7 exclusion by the F plasmid
B224_4496	COG1027	Aspartate ammonia-lyase
B224_4498	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B224_4499	COG2918	glutathione biosynthetic process
B224_4502	COG0612	Peptidase, M16
B224_4503	COG1238	metal cluster binding
B224_4504	COG1064	alcohol dehydrogenase
B224_4511	COG0359	binds to the 23S rRNA
B224_4513	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B224_4514	COG0360	Binds together with S18 to 16S ribosomal RNA
B224_4515	COG1914	H( )-stimulated, divalent metal cation uptake system
B224_4519	COG2153	protein acetylation
B224_4523	COG0557	exoribonuclease II activity
B224_4525	COG3706	GGDEF domain
B224_4527	COG1854	S-ribosylhomocysteine lyase activity
B224_4531	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B224_4531	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_4532	COG5433	transposase activity
B224_4536	COG1484	DNA-dependent DNA replication
B224_4537	COG4584	PFAM Integrase catalytic
B224_4540	COG3385	transposase activity
B224_4546	COG5433	transposase activity
B224_4548	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B224_4549	COG1047	Peptidyl-prolyl cis-trans
B224_4550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B224_4553	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B224_4554	COG0196	riboflavin kinase activity
B224_4556	COG0728	peptidoglycan biosynthetic process
B224_4559	COG0268	Binds directly to 16S ribosomal RNA
B224_4560	COG0640	Transcriptional regulator
B224_4562	COG0583	DNA-binding transcription factor activity
B224_4564	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B224_4565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B224_4566	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B224_4569	COG1051	belongs to the nudix hydrolase family
B224_4572	COG0335	large ribosomal subunit rRNA binding
B224_4573	COG0336	Belongs to the RNA methyltransferase TrmD family
B224_4574	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B224_4575	COG0228	four-way junction DNA binding
B224_4577	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B224_4578	COG4137	Cytochrome C assembly protein
B224_4580	COG4536	flavin adenine dinucleotide binding
B224_4582	COG1017	nitric oxide dioxygenase activity
B224_4582	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_4584	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B224_4585	COG0039	L-malate dehydrogenase activity
B224_4586	COG4160	amino acid transport
B224_4587	COG4215	(ABC) transporter
B224_4589	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_4591	COG1126	abc transporter atp-binding protein
B224_4592	COG1438	arginine binding
B224_4593	COG2837	iron assimilation
B224_4598	COG1840	ABC-type Fe3 transport system, periplasmic component
B224_4599	COG0347	Belongs to the P(II) protein family
B224_4603	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_4605	COG0583	DNA-binding transcription factor activity
B224_4611	COG1929	Belongs to the glycerate kinase type-1 family
B224_4612	COG2610	gluconate transmembrane transporter activity
B224_4615	COG3835	regulator
B224_4616	COG3112	Uncharacterised protein family (UPF0231)
B224_4620	COG1872	DUF167
B224_4621	COG0762	integral membrane protein
B224_4622	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B224_4623	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B224_4628	COG3022	response to hydroperoxide
B224_4629	COG0513	Belongs to the DEAD box helicase family
B224_4631	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B224_4637	COG0735	belongs to the Fur family
B224_4639	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_4643	COG0776	regulation of translation
B224_4645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
B224_4647	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B224_4652	COG0560	Phosphoserine phosphatase
B224_4654	COG3064	Membrane
B224_4658	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B224_4659	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B224_4661	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B224_4665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_4666	COG0084	hydrolase, TatD family'
B224_4672	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_4674	COG0004	ammonium transporteR
B224_4677	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_4680	COG0438	transferase activity, transferring glycosyl groups
B224_4686	COG1401	restriction endodeoxyribonuclease activity
B224_4690	COG3385	transposase activity
B224_4700	COG0795	lipopolysaccharide-transporting ATPase activity
B224_4703	COG0795	lipopolysaccharide-transporting ATPase activity
B224_4704	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_4706	COG2927	DNA polymerase III (CHI subunit)
B224_4708	COG0525	valine-tRNA ligase activity
B224_4709	COG1253	flavin adenine dinucleotide binding
B224_4711	COG0586	Pfam SNARE associated Golgi protein
B224_4712	COG1686	Belongs to the peptidase S11 family
B224_4713	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B224_4714	COG0527	aspartate kinase activity
B224_4716	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B224_4721	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B224_4722	COG1546	Belongs to the CinA family
B224_4725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B224_4730	COG3068	Protein conserved in bacteria
B224_4734	COG0739	heme binding
B224_4741	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B224_4742	COG1121	(ABC) transporter
B224_4743	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B224_4744	COG0583	DNA-binding transcription factor activity
B224_4746	COG1573	uracil-dna glycosylase
B224_4748	COG2827	Endonuclease containing a URI domain
B224_4751	COG1842	Phage shock protein A
B224_4752	COG0204	Acyl-transferase
B224_4758	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_4774	COG3039	Transposase
B224_4779	COG0187	DNA topoisomerase II activity
B224_4781	COG1051	belongs to the nudix hydrolase family
B224_4782	COG3150	esterase
B224_4784	COG3151	Protein conserved in bacteria
B224_4785	COG0494	nUDIX hydrolase
B224_4786	COG1538	Outer membrane efflux protein
B224_4788	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B224_4788	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B224_4790	COG1560	Kdo2-lipid A biosynthetic process
B224_4799	COG2771	luxR family
B224_4804	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B224_4807	COG4584	PFAM Integrase catalytic
B224_4808	COG1484	DNA-dependent DNA replication
B224_4811	COG2213	PTS system mannitol-specific
B224_4811	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_4813	COG0246	Mannitol dehydrogenase
B224_4815	COG3722	fumarate hydratase activity
B224_4823	COG1671	Belongs to the UPF0178 family
B224_4827	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_4831	COG5433	transposase activity
B224_4832	COG0513	Belongs to the DEAD box helicase family
B224_4840	COG1575	Belongs to the MenA family. Type 1 subfamily
B224_4841	COG1169	isochorismate synthase
B224_4842	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B224_4844	COG0596	Alpha beta hydrolase
B224_4846	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B224_4847	COG1441	menaquinone biosynthetic process
B224_4849	COG0318	PFAM AMP-dependent synthetase and ligase
B224_4851	COG3291	Pkd domain containing protein
B224_4852	COG2949	membrane
B224_4857	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B224_4864	COG2873	o-acetylhomoserine
B224_4868	COG1979	alcohol dehydrogenase
B224_4871	COG4221	oxidoreductase activity
B224_4880	COG1368	sulfuric ester hydrolase activity
B224_4887	COG3047	cAMP biosynthetic process
B224_4893	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B224_4894	COG2197	response regulator
B224_4895	COG0629	single-stranded DNA binding
B224_4900	COG2205	protein histidine kinase activity
B224_4902	COG0745	RESPONSE REGULATOR receiver
B224_4909	COG3706	GGDEF domain
B224_4910	COG0347	Belongs to the P(II) protein family
B224_4911	COG0004	ammonium transporteR
B224_4914	COG0346	lactoylglutathione lyase activity
B224_4917	COG5433	transposase activity
B224_4919	COG3039	Transposase
B224_4920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B224_4923	COG1074	ATP-dependent DNA helicase activity
B224_4926	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B224_4927	COG2259	Doxx family
B224_4929	COG1741	Belongs to the pirin family
B224_4931	COG0583	DNA-binding transcription factor activity
B224_4938	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_4941	COG3842	ATPase activity
B224_4945	COG2199	diguanylate cyclase activity
B224_4945	COG2203	Gaf domain
B224_4948	COG2207	Transcriptional regulator
B224_4949	COG0456	acetyltransferase
B224_4949	COG0454	-acetyltransferase
B224_4951	COG0753	catalase activity
B224_4960	COG0628	permease
B224_4964	COG3284	Transcriptional regulator
B224_4969	COG1461	Dihydroxyacetone kinase
B224_4970	COG2376	Dihydroxyacetone kinase
B224_4972	COG2252	PERMEase
B224_4974	COG4584	PFAM Integrase catalytic
B224_4975	COG1484	DNA-dependent DNA replication
B224_4979	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B224_4981	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B224_4984	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B224_4985	COG0049	tRNA binding
B224_4986	COG2168	tRNA wobble position uridine thiolation
B224_4991	COG2964	Protein conserved in bacteria
B224_4994	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B224_4997	COG0085	RNA polymerase activity
B224_4998	COG0222	ribosome binding
B224_4999	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B224_5000	COG0081	regulation of translation
B224_5002	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B224_5003	COG0250	Participates in transcription elongation, termination and antitermination
B224_5005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B224_5006	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B224_5010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B224_5013	COG0569	domain protein
B224_5014	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_5017	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B224_5018	COG3005	denitrification pathway
B224_5020	COG0243	molybdopterin cofactor binding
B224_5023	COG2205	protein histidine kinase activity
B224_5025	COG0745	RESPONSE REGULATOR receiver
B224_5029	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B224_5033	COG2204	response regulator
B224_5037	COG2205	protein histidine kinase activity
B224_5040	COG0516	GMP reductase activity
B224_5040	COG0517	IMP dehydrogenase activity
B224_5042	COG5413	integral membrane protein
B224_5046	COG1522	sequence-specific DNA binding
B224_5047	COG2502	aspartate--ammonia ligase
B224_5049	COG0542	response to heat
B224_5051	COG0564	pseudouridine synthase activity
B224_5052	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_5053	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_5055	COG3681	Belongs to the UPF0597 family
B224_5058	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B224_5059	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B224_5062	COG1979	alcohol dehydrogenase
B224_5063	COG2207	Transcriptional regulator
B224_5065	COG3040	lipid binding
B224_5071	COG0688	phosphatidylethanolamine metabolic process
B224_5073	COG0540	Belongs to the ATCase OTCase family
B224_5074	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B224_5075	COG1438	arginine binding
B224_5076	COG1288	antiporter activity
B224_5077	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B224_5084	COG3385	transposase activity
B224_5089	COG4211	Belongs to the binding-protein-dependent transport system permease family
B224_5091	COG1129	ABC transporter
B224_5095	COG3250	beta-galactosidase activity
B224_5096	COG1609	Transcriptional regulator
B224_5097	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_5099	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B224_5101	COG2017	converts alpha-aldose to the beta-anomer
B224_5102	COG0667	Aldo Keto reductase
B224_5103	COG1968	undecaprenyl-diphosphatase activity
B224_5104	COG3806	Anti-sigma factor
B224_5105	COG1595	DNA-templated transcription, initiation
B224_5107	COG0018	arginyl-trna synthetase
B224_5110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B224_5111	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B224_5116	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_5117	COG1131	(ABC) transporter
B224_5118	COG0842	Transport permease protein
B224_5120	COG0842	Transport permease protein
B224_5123	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_5125	COG2146	nitrite reductase [NAD(P)H] activity
B224_5126	COG2116	formate transmembrane transporter activity
B224_5127	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B224_5127	COG1648	precorrin-2 dehydrogenase activity
B224_5128	COG2239	Acts as a magnesium transporter
B224_5130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B224_5131	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B224_5133	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B224_5138	COG0514	ATP-dependent DNA helicase (RecQ)
B224_5141	COG2050	protein possibly involved in aromatic compounds catabolism
B224_5148	COG2258	MOSC domain
B224_5150	COG1177	transmembrane transport
B224_5152	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_5155	COG3842	ATPase activity
B224_5162	COG0174	glutamine synthetase
B224_5163	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B224_5169	COG3045	CreA protein
B224_5170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B224_5172	COG0443	Heat shock 70 kDa protein
B224_5175	COG0366	Alpha amylase catalytic
B224_5182	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_5183	COG0745	RESPONSE REGULATOR receiver
B224_5185	COG2205	protein histidine kinase activity
B224_5188	COG0281	malic enzyme
B224_5189	COG0702	epimerase
B224_5190	COG0254	rRNA binding
B224_5192	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B224_5196	COG3039	Transposase
B224_5200	COG5433	transposase activity
B224_5204	COG0129	dihydroxy-acid dehydratase activity
B224_5206	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B224_5207	COG3978	acetolactate synthase activity
B224_5210	COG0606	chelatase, subunit chli
B224_5211	COG0204	Acyl-transferase
B224_5212	COG0204	Acyl-transferase
B224_5217	COG1335	isochorismatase
B224_5219	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B224_5220	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B224_5221	COG3639	organic phosphonate transmembrane transporter activity
B224_5223	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B224_5224	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B224_5229	COG3084	Protein conserved in bacteria
B224_5230	COG4251	negative regulation of phosphorylation
B224_5230	COG3706	GGDEF domain
B224_5230	COG2203	Gaf domain
B224_5230	COG5001	Diguanylate cyclase
B224_5231	COG0789	Transcriptional regulator
B224_5234	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B224_5235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B224_5236	COG1561	YicC-like family, N-terminal region
B224_5239	COG1519	Transferase
B224_5241	COG0859	PFAM glycosyl transferase family 9
B224_5242	COG0463	Glycosyl transferase, family 2
B224_5244	COG0859	PFAM glycosyl transferase family 9
B224_5246	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B224_5247	COG2990	Protein conserved in bacteria
B224_5249	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B224_5251	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B224_5252	COG2003	Belongs to the UPF0758 family
B224_5254	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B224_5255	COG0756	dUTP diphosphatase activity
B224_5257	COG1309	transcriptional regulator
B224_5258	COG0668	transmembrane transport
B224_5260	COG0166	Belongs to the GPI family
B224_5262	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B224_5264	COG0583	DNA-binding transcription factor activity
B224_5266	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_5266	COG1042	CoA-binding domain protein
B224_5266	COG0045	succinate-CoA ligase (ADP-forming) activity
B224_5269	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B224_5272	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B224_5273	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B224_5276	COG2223	nitrite transmembrane transporter activity
B224_5277	COG3279	Response regulator of the LytR AlgR family
B224_5279	COG3275	phosphorelay sensor kinase activity
B224_5283	COG2223	nitrite transmembrane transporter activity
B224_5284	COG2081	HI0933 family
B224_5286	COG1528	Iron-storage protein
B224_5287	COG3706	GGDEF domain
B224_5288	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B224_5289	COG0589	response to stress
B224_5298	COG0859	PFAM glycosyl transferase family 9
B224_5301	COG1758	RNA polymerase activity
B224_5302	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B224_5305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B224_5306	COG2267	carboxylic ester hydrolase activity
B224_5307	COG0561	phosphatase activity
B224_5309	COG1309	transcriptional regulator
B224_5310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_5312	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_5315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_5315	COG4191	Histidine kinase
B224_5316	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B224_5319	COG0604	alcohol dehydrogenase
B224_5321	COG1733	regulation of RNA biosynthetic process
B224_5329	COG2205	protein histidine kinase activity
B224_5331	COG0745	RESPONSE REGULATOR receiver
B224_5333	COG2814	Major facilitator Superfamily
B224_5336	COG3977	Valine--pyruvate aminotransferase
B224_5338	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_5340	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_5342	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B224_5344	COG2378	regulation of single-species biofilm formation
B224_5347	COG0187	DNA topoisomerase II activity
B224_5349	COG0592	DNA-directed DNA polymerase activity
B224_5351	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B224_5355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B224_5356	COG0594	ribonuclease P activity
B224_5357	COG0706	membrane insertase activity
B224_5358	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B224_5359	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_5360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_5361	COG1120	ATPase activity
B224_5363	COG4615	Cyclic peptide transporter
B224_5365	COG4774	siderophore transport
B224_5367	COG0716	FMN binding
B224_5370	COG0445	tRNA wobble uridine modification
B224_5371	COG0357	Ribosomal RNA small subunit methyltransferase G
B224_5373	COG1192	Involved in chromosome partitioning
B224_5374	COG1475	DNA binding
B224_5375	COG0356	it plays a direct role in the translocation of protons across the membrane
B224_5377	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B224_5379	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B224_5380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B224_5382	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B224_5384	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B224_5385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B224_5387	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B224_5388	COG4452	Inner membrane protein CreD
B224_5392	COG2205	protein histidine kinase activity
B224_5393	COG0745	RESPONSE REGULATOR receiver
B224_5395	COG1349	DNA-binding transcription factor activity
B224_5397	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B224_5399	COG2771	luxR family
B224_5401	COG0811	peptide transport
B224_5404	COG0811	peptide transport
B224_5405	COG0848	biopolymer transport protein
B224_5406	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B224_5410	COG1609	Transcriptional regulator
B224_5413	COG3250	beta-galactosidase activity
B224_5414	COG2731	YhcH YjgK YiaL family protein
B224_5415	COG0531	amino acid
B224_5417	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_5418	COG0531	amino acid
B224_5419	COG0385	Bile acid
B224_5422	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B224_5429	COG0583	DNA-binding transcription factor activity
B224_5443	COG0210	DNA helicase
B224_5451	COG2391	methyltransferase activity
B224_5453	COG1280	lysine exporter protein (LysE YggA)
B224_5456	COG2962	Rard protein
B224_5460	COG1012	belongs to the aldehyde dehydrogenase family
B224_5463	COG1396	sequence-specific DNA binding
B224_5468	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B224_5468	COG0519	Catalyzes the synthesis of GMP from XMP
B224_5470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_5475	COG1322	Protein conserved in bacteria
B224_5477	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_5478	COG0569	domain protein
B224_5479	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_5479	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_5480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B224_5482	COG0242	peptide deformylase activity
B224_5485	COG0758	DNA mediated transformation
B224_5486	COG2922	Belongs to the Smg family
B224_5487	COG0551	DNA topoisomerase type I activity
B224_5488	COG0009	L-threonylcarbamoyladenylate synthase
B224_5489	COG0408	coproporphyrinogen oxidase activity
B224_5490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B224_5491	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B224_5493	COG3078	GTPase activator activity
B224_5496	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B224_5499	COG5433	transposase activity
B224_5501	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B224_5504	COG3852	Histidine kinase
B224_5508	COG0174	glutamine synthetase
B224_5510	COG1295	ribonuclease BN
B224_5512	COG1295	ribonuclease BN
B224_5514	COG1490	D-aminoacyl-tRNA deacylase activity
B224_5518	COG0456	acetyltransferase
B224_5522	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B224_5523	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B224_5524	COG2610	gluconate transmembrane transporter activity
B224_5525	COG3265	gluconokinase activity
B224_5526	COG0129	dihydroxy-acid dehydratase activity
B224_5527	COG0800	Aldolase
B224_5529	COG1609	Transcriptional regulator
B224_5533	COG4942	peptidase
B224_5534	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_5535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B224_5536	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B224_5537	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B224_5538	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B224_5538	COG0316	Belongs to the HesB IscA family
B224_5540	COG1040	competence protein
B224_5541	COG0596	Alpha beta hydrolase
B224_5545	COG2183	response to ionizing radiation
B224_5547	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B224_5548	COG0745	RESPONSE REGULATOR receiver
B224_5549	COG2205	protein histidine kinase activity
B224_5551	COG0051	transcription antitermination factor activity, RNA binding
B224_5552	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B224_5553	COG0088	Forms part of the polypeptide exit tunnel
B224_5554	COG0089	rRNA binding
B224_5555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B224_5556	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B224_5557	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B224_5558	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B224_5560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B224_5561	COG0255	Belongs to the universal ribosomal protein uL29 family
B224_5562	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B224_5563	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B224_5564	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B224_5565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B224_5566	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B224_5567	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B224_5568	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B224_5569	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B224_5571	COG0201	protein transport
B224_5573	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B224_5574	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B224_5576	COG0202	RNA polymerase activity
B224_5579	COG1484	DNA-dependent DNA replication
B224_5580	COG4584	PFAM Integrase catalytic
B224_5581	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B224_5582	COG0402	S-adenosylhomocysteine deaminase activity
B224_5584	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B224_5586	COG3165	ubiquinone biosynthetic process from chorismate
B224_5588	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B224_5589	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_5590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_5591	COG0805	protein transport
B224_5593	COG0084	hydrolase, TatD family'
B224_5600	COG0742	ribosomal rna small subunit methyltransferase
B224_5604	COG0248	Ppx GppA phosphatase
B224_5605	COG0513	Belongs to the DEAD box helicase family
B224_5606	COG3118	belongs to the thioredoxin family
B224_5607	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B224_5609	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B224_5618	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_5627	COG0559	Belongs to the binding-protein-dependent transport system permease family
B224_5629	COG1609	Transcriptional regulator
B224_5631	COG3604	Transcriptional regulator
B224_5633	COG1773	rubredoxin
B224_5633	COG0426	domain, Protein
B224_5635	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_5639	COG0348	domain, Protein
B224_5643	COG5433	transposase activity
B224_5644	COG0814	amino acid
B224_5645	COG0814	amino acid
B224_5650	COG0751	glycine-tRNA ligase activity
B224_5652	COG0752	glycyl-tRNA synthetase alpha subunit
B224_5653	COG2818	Glycosylase
B224_5660	COG2885	chlorophyll binding
B224_5661	COG0251	oxidation-reduction process
B224_5663	COG0425	Belongs to the sulfur carrier protein TusA family
B224_5666	COG1653	transport
B224_5670	COG0745	RESPONSE REGULATOR receiver
B224_5671	COG0183	Belongs to the thiolase family
B224_5673	COG1250	3-hydroxyacyl-CoA dehydrogenase
B224_5673	COG1024	Enoyl-CoA hydratase
B224_5674	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B224_5676	COG0006	proline dipeptidase activity
B224_5677	COG1739	Uncharacterized protein family UPF0029
B224_5679	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_5680	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B224_5682	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B224_5685	COG2166	iron-sulfur cluster assembly
B224_5686	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B224_5687	COG0210	DNA helicase
B224_5691	COG1063	alcohol dehydrogenase
B224_5694	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B224_5696	COG0438	transferase activity, transferring glycosyl groups
B224_5698	COG3307	-O-antigen
B224_5703	COG5433	transposase activity
B224_5706	COG0604	alcohol dehydrogenase
B224_5711	COG1580	Controls the rotational direction of flagella during chemotaxis
B224_5712	COG3161	chorismate lyase activity
B224_5713	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B224_5715	COG2937	Belongs to the GPAT DAPAT family
B224_5716	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_5721	COG0534	Mate efflux family protein
B224_5722	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B224_5723	COG2205	protein histidine kinase activity
B224_5724	COG0745	RESPONSE REGULATOR receiver
B224_5727	COG1045	serine acetyltransferase
B224_5729	COG3074	FtsZ-dependent cytokinesis
B224_5730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B224_5732	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_5732	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_5734	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B224_5742	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
B224_5744	COG3706	GGDEF domain
B224_5745	COG0513	Belongs to the DEAD box helicase family
B224_5762	COG0154	amidase activity
B224_5764	COG2957	Belongs to the agmatine deiminase family
B224_5771	COG1902	pentaerythritol trinitrate reductase activity
B224_5775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B224_5777	COG3706	GGDEF domain
B224_5777	COG0745	RESPONSE REGULATOR receiver
B224_5778	COG5001	Diguanylate cyclase
B224_5778	COG3300	MHYT domain
B224_5781	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B224_5785	COG0456	acetyltransferase
B224_5788	COG1022	Amp-dependent synthetase and ligase
B224_5791	COG1794	racemase activity, acting on amino acids and derivatives
B224_5794	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_5798	COG0733	neurotransmitter:sodium symporter activity
B224_5799	COG0733	neurotransmitter:sodium symporter activity
B224_5802	COG0561	phosphatase activity
B224_5808	COG1522	sequence-specific DNA binding
B224_5813	COG1846	Transcriptional regulator
B224_5814	COG2130	NADP-dependent
B224_5827	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B224_5829	COG1640	4-alpha-glucanotransferase
B224_5830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B224_5833	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B224_5835	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B224_5836	COG2885	chlorophyll binding
B224_5837	COG0823	Involved in the tonB-independent uptake of proteins
B224_5840	COG0811	peptide transport
B224_5842	COG0824	Thioesterase
B224_5843	COG3790	cyd operon protein YbgE
B224_5844	COG4890	Cyd operon protein YbgT
B224_5845	COG1294	oxidase, subunit
B224_5847	COG1271	oxidase subunit
B224_5849	COG2255	four-way junction helicase activity
B224_5851	COG0632	four-way junction helicase activity
B224_5852	COG0442	prolyl-tRNA aminoacylation
B224_5854	COG4221	oxidoreductase activity
B224_5858	COG1024	Enoyl-CoA hydratase
B224_5861	COG4166	transmembrane transport
B224_5864	COG0840	transmembrane signaling receptor activity
B224_5866	COG3568	Endonuclease Exonuclease Phosphatase
B224_5871	COG0513	Belongs to the DEAD box helicase family
B224_5877	COG3385	transposase activity
B224_5884	COG0457	Tetratricopeptide repeat
B224_5884	COG3118	belongs to the thioredoxin family
B224_5887	COG1215	transferase activity, transferring glycosyl groups
B224_5895	COG2194	sulfuric ester hydrolase activity
B224_5900	COG1448	Aminotransferase
B224_5904	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B224_5906	COG1328	CTP reductase activity
B224_5916	COG0840	transmembrane signaling receptor activity
B224_5919	COG3397	chitin binding
B224_5923	COG0583	DNA-binding transcription factor activity
B224_5924	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B224_5926	COG4208	sulfate ABC transporter
B224_5927	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B224_5929	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B224_5932	COG1396	sequence-specific DNA binding
B224_5933	COG3135	benzoate transporter
B224_5935	COG1522	sequence-specific DNA binding
B224_5938	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B224_5942	COG1058	Belongs to the CinA family
B224_5942	COG1546	Belongs to the CinA family
B224_5943	COG1988	membrane-bound metal-dependent
B224_5945	COG0561	phosphatase activity
B224_5946	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B224_5949	COG1011	Hydrolase
B224_5953	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B224_5955	COG0019	diaminopimelate decarboxylase activity
B224_5957	COG1965	Belongs to the frataxin family
B224_5958	COG0400	carboxylic ester hydrolase activity
B224_5961	COG3072	Adenylate cyclase
B224_5962	COG0181	hydroxymethylbilane synthase activity
B224_5966	COG2959	enzyme of heme biosynthesis
B224_5968	COG3071	HemY protein
B224_5972	COG1494	fructose-1,6-bisphosphatase
B224_5975	COG1247	-acetyltransferase
B224_5983	COG1733	regulation of RNA biosynthetic process
B224_5986	COG3932	Exopolysaccharide synthesis, ExoD
B224_5988	COG3706	GGDEF domain
B224_5996	COG3039	Transposase
B224_5997	COG3039	Transposase
B224_5998	COG3385	transposase activity
B224_6000	COG3385	transposase activity
B224_6001	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B224_6002	COG2022	thiamine diphosphate biosynthetic process
B224_6005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B224_6006	COG0352	thiamine-phosphate diphosphorylase activity
B224_6007	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B224_6010	COG3385	transposase activity
B224_6012	COG5433	transposase activity
B224_6016	COG0745	RESPONSE REGULATOR receiver
B224_6019	COG0189	ligase activity
B224_6027	COG3039	Transposase
B224_6028	COG5433	transposase activity
B224_6030	COG5433	transposase activity
B224_6032	COG3039	Transposase
B224_6033	COG1484	DNA-dependent DNA replication
B224_6039	COG2321	neutral zinc metallopeptidase
B224_6040	COG3385	transposase activity
B224_6041	COG2321	neutral zinc metallopeptidase
B224_6043	COG0477	Major facilitator Superfamily
B224_6049	COG0312	modulator of DNA gyrase
B224_6050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_6053	COG3164	Protein of unknown function
B224_6055	COG1530	ribonuclease E activity
B224_6056	COG0424	maF-like protein
B224_6057	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B224_6058	COG1792	Involved in formation and maintenance of cell shape
B224_6059	COG1077	Cell shape determining protein MreB Mrl
B224_6061	COG5433	transposase activity
B224_6074	COG2199	diguanylate cyclase activity
B224_6074	COG2200	EAL domain
B224_6075	COG3039	Transposase
B224_6077	COG2200	EAL domain
B224_6078	COG0387	Pfam Sodium calcium exchanger
B224_6080	COG2986	histidine ammonia-lyase
B224_6082	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B224_6084	COG0010	Belongs to the arginase family
B224_6086	COG1228	amidohydrolase
B224_6088	COG2188	Transcriptional regulator
B224_6089	COG0288	reversible hydration of carbon dioxide
B224_6091	COG2177	Part of the ABC transporter FtsEX involved in
B224_6092	COG2884	Cell division ATP-binding protein ftsE
B224_6094	COG0552	protein localization to endoplasmic reticulum
B224_p00003	COG1192	Involved in chromosome partitioning