locus-tag	class	description
ASfcp2_198	COG1051	belongs to the nudix hydrolase family
ASfcp2_198	COG1056	cytidyltransferase-related domain
ASfcp2_208	COG0617	tRNA 3'-terminal CCA addition
ASfcp2_221	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASfcp2_245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASfcp2_254	COG0187	DNA topoisomerase II activity
ASfcp2_259	COG0756	dUTP diphosphatase activity
ASfcp2_269	COG2255	four-way junction helicase activity
ASfcp2_272	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASfcp2_282	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ASfcp2_283	COG1328	CTP reductase activity
ASfcp2_285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASfcp2_286	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASfcp2_73	COG1435	thymidine kinase activity