locus-tag	class	description
ASwh1_113	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASwh1_143	COG0187	DNA topoisomerase II activity
ASwh1_148	COG0756	dUTP diphosphatase activity
ASwh1_158	COG0417	DNA replication proofreading
ASwh1_167	COG0419	ATPase involved in DNA repair
ASwh1_180	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ASwh1_181	COG0602	queuosine metabolic process
ASwh1_182	COG1328	CTP reductase activity
ASwh1_183	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASwh1_184	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASwh1_262	COG0484	heat shock protein binding
ASwh1_280	COG1435	thymidine kinase activity
ASwh1_301	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASwh1_59	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis