locus-tag	class	description
ZPAH1_orf00027	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ZPAH1_orf00107	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZPAH1_orf00109	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZPAH1_orf00121	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZPAH1_orf00163	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZPAH1_orf00188	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZPAH1_orf00192	COG0187	DNA topoisomerase II activity
ZPAH1_orf00197	COG0756	dUTP diphosphatase activity
ZPAH1_orf00207	COG0417	DNA replication proofreading
ZPAH1_orf00216	COG0419	ATPase involved in DNA repair
ZPAH1_orf00228	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ZPAH1_orf00230	COG1328	CTP reductase activity
ZPAH1_orf00232	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZPAH1_orf00233	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZPAH1_orf00310	COG0484	heat shock protein binding
ZPAH1_orf00326	COG1435	thymidine kinase activity
ZPAH1_orf00347	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner