locus-tag	class	description
O23A_P3p0004	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O23A_P3p0022	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_P3p0035	COG3451	type IV secretory pathway VirB4
O23A_P3p0046	COG2771	luxR family
O23A_P3p0062	COG1192	Involved in chromosome partitioning
O23A_P4p0008	COG2003	Belongs to the UPF0758 family
O23A_P4p0017	COG1598	PFAM Uncharacterised protein family UPF0150
O23A_P4p0018	COG1724	mRNA binding
O23A_P4p0027	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_P4p0037	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_P4p0043	COG1192	Involved in chromosome partitioning
O23A_p0001	COG0835	chemotaxis
O23A_p0001	COG0784	Response regulator, receiver
O23A_p0002	COG2755	lipolytic protein G-D-S-L family
O23A_p0003	COG4181	ATPase activity
O23A_p0004	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O23A_p0005	COG1090	epimerase
O23A_p0006	COG2200	EAL domain
O23A_p0007	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_p0009	COG2234	aminopeptidase activity
O23A_p0009	COG4935	Belongs to the peptidase S8 family
O23A_p0010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O23A_p0011	COG3171	Protein conserved in bacteria
O23A_p0012	COG2066	Belongs to the glutaminase family
O23A_p0013	COG2897	thiosulfate sulfurtransferase activity
O23A_p0015	COG1132	(ABC) transporter
O23A_p0019	COG1012	belongs to the aldehyde dehydrogenase family
O23A_p0020	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O23A_p0023	COG3291	Pkd domain containing protein
O23A_p0023	COG4412	M6 family metalloprotease domain protein
O23A_p0025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
O23A_p0026	COG3300	MHYT domain
O23A_p0026	COG5001	Diguanylate cyclase
O23A_p0030	COG4628	conserved protein (DUF2132)
O23A_p0031	COG0688	phosphatidylethanolamine metabolic process
O23A_p0032	COG1162	GTPase activity
O23A_p0033	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O23A_p0034	COG1278	Cold shock
O23A_p0036	COG0840	transmembrane signaling receptor activity
O23A_p0037	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_p0038	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_p0043	COG0848	biopolymer transport protein
O23A_p0044	COG0811	peptide transport
O23A_p0045	COG0811	peptide transport
O23A_p0047	COG4206	TonB-dependent receptor
O23A_p0048	COG4174	ABC transporter (Permease)
O23A_p0049	COG4239	(ABC) transporter, permease
O23A_p0050	COG0747	negative chemotaxis
O23A_p0051	COG0444	Belongs to the ABC transporter superfamily
O23A_p0052	COG4608	Belongs to the ABC transporter superfamily
O23A_p0054	COG2195	Cleaves the N-terminal amino acid of tripeptides
O23A_p0057	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O23A_p0060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O23A_p0061	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O23A_p0067	COG0243	molybdopterin cofactor binding
O23A_p0070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O23A_p0071	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O23A_p0072	COG1116	anion transmembrane transporter activity
O23A_p0073	COG2146	nitrite reductase [NAD(P)H] activity
O23A_p0073	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_p0074	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_p0074	COG2146	nitrite reductase [NAD(P)H] activity
O23A_p0076	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_p0077	COG2313	pseudouridylate synthase activity
O23A_p0080	COG1858	cytochrome C peroxidase
O23A_p0087	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_p0088	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_p0090	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p0093	COG2986	histidine ammonia-lyase
O23A_p0099	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_p0101	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p0102	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_p0104	COG0521	Mo-molybdopterin cofactor biosynthetic process
O23A_p0106	COG2966	Psort location CytoplasmicMembrane, score
O23A_p0108	COG3610	response to peptide
O23A_p0110	COG4175	Glycine betaine
O23A_p0111	COG4176	ABC-type proline glycine betaine transport system permease component
O23A_p0112	COG2113	Glycine betaine
O23A_p0113	COG0175	sulfate reduction
O23A_p0114	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_p0115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O23A_p0116	COG0384	phenazine biosynthesis protein PhzF
O23A_p0117	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O23A_p0118	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O23A_p0120	COG0786	glutamate:sodium symporter activity
O23A_p0121	COG0252	asparaginase activity
O23A_p0122	COG3139	Protein of unknown function (DUF1315)
O23A_p0126	COG0616	signal peptide processing
O23A_p0127	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_p0127	COG1902	pentaerythritol trinitrate reductase activity
O23A_p0128	COG0778	Nitroreductase
O23A_p0129	COG0110	maltose O-acetyltransferase activity
O23A_p0130	COG2264	protein methyltransferase activity
O23A_p0132	COG0604	alcohol dehydrogenase
O23A_p0133	COG0583	DNA-binding transcription factor activity
O23A_p0134	COG1263	PTS System
O23A_p0134	COG2190	(PTS) system
O23A_p0134	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_p0135	COG4145	pantothenate transmembrane transporter activity
O23A_p0136	COG3924	membrane
O23A_p0137	COG0439	Biotin carboxylase
O23A_p0138	COG0511	ligase activity, forming carbon-carbon bonds
O23A_p0139	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O23A_p0140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O23A_p0146	COG3381	protein complex oligomerization
O23A_p0150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O23A_p0153	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O23A_p0154	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O23A_p0154	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O23A_p0157	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O23A_p0158	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_p0159	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O23A_p0160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O23A_p0165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O23A_p0166	COG0142	geranyltranstransferase activity
O23A_p0167	COG1722	exodeoxyribonuclease VII activity
O23A_p0168	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_p0169	COG1360	Flagellar Motor Protein
O23A_p0173	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O23A_p0175	COG1534	Rna-binding protein
O23A_p0176	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O23A_p0177	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O23A_p0178	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O23A_p0179	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O23A_p0180	COG0149	triose-phosphate isomerase activity
O23A_p0181	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O23A_p0182	COG0779	Required for maturation of 30S ribosomal subunits
O23A_p0183	COG0195	Participates in both transcription termination and antitermination
O23A_p0184	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O23A_p0185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O23A_p0186	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O23A_p0187	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O23A_p0188	COG1185	polyribonucleotide nucleotidyltransferase activity
O23A_p0189	COG2211	Major facilitator Superfamily
O23A_p0190	COG3706	GGDEF domain
O23A_p0191	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O23A_p0192	COG1422	Protein of unknown function (DUF1090)
O23A_p0193	COG0114	fumarate hydratase activity
O23A_p0194	COG2197	response regulator
O23A_p0212	COG0312	modulator of DNA gyrase
O23A_p0214	COG0716	FMN binding
O23A_p0215	COG4974	Belongs to the 'phage' integrase family
O23A_p0216	COG1970	mechanosensitive ion channel activity
O23A_p0218	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O23A_p0222	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p0223	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O23A_p0225	COG0321	lipoyl(octanoyl) transferase activity
O23A_p0226	COG2921	Belongs to the UPF0250 family
O23A_p0227	COG1686	Belongs to the peptidase S11 family
O23A_p0228	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O23A_p0229	COG2951	lytic endotransglycosylase activity
O23A_p0230	COG0772	Belongs to the SEDS family
O23A_p0231	COG0768	penicillin binding
O23A_p0232	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O23A_p0233	COG0799	negative regulation of ribosome biogenesis
O23A_p0234	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O23A_p0238	COG0495	leucyl-tRNA aminoacylation
O23A_p0239	COG2888	peptidyl-tyrosine sulfation
O23A_p0240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O23A_p0241	COG4535	Mg2 and Co2 transporter CorC
O23A_p0242	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O23A_p0243	COG1702	phosphate starvation-inducible protein PhoH
O23A_p0244	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O23A_p0245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_p0247	COG3706	GGDEF domain
O23A_p0250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_p0257	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O23A_p0259	COG0516	GMP reductase activity
O23A_p0261	COG0642	Histidine kinase
O23A_p0262	COG0745	RESPONSE REGULATOR receiver
O23A_p0266	COG1022	Amp-dependent synthetase and ligase
O23A_p0269	COG3214	Protein conserved in bacteria
O23A_p0273	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O23A_p0274	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O23A_p0275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O23A_p0276	COG1053	succinate dehydrogenase
O23A_p0280	COG0584	glycerophosphoryl diester phosphodiesterase
O23A_p0281	COG1511	domain protein
O23A_p0281	COG3264	Mechanosensitive ion channel
O23A_p0283	COG0739	heme binding
O23A_p0286	COG0583	DNA-binding transcription factor activity
O23A_p0289	COG0840	transmembrane signaling receptor activity
O23A_p0290	COG0583	DNA-binding transcription factor activity
O23A_p0291	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O23A_p0297	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O23A_p0298	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O23A_p0300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O23A_p0302	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O23A_p0303	COG0546	phosphoglycolate phosphatase activity
O23A_p0304	COG0180	Tryptophanyl-tRNA synthetase
O23A_p0307	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O23A_p0309	COG1012	belongs to the aldehyde dehydrogenase family
O23A_p0311	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_p0313	COG0674	pyruvate-flavodoxin oxidoreductase activity
O23A_p0313	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O23A_p0313	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p0313	COG1013	pyruvate-flavodoxin oxidoreductase activity
O23A_p0315	COG0488	(ABC) transporter
O23A_p0318	COG0366	Alpha amylase catalytic
O23A_p0322	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O23A_p0324	COG0490	domain, Protein
O23A_p0324	COG0471	metal ion transport
O23A_p0325	COG0012	GTP binding
O23A_p0326	COG0193	aminoacyl-tRNA hydrolase activity
O23A_p0327	COG0737	Belongs to the 5'-nucleotidase family
O23A_p0328	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O23A_p0329	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O23A_p0330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O23A_p0331	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O23A_p0332	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O23A_p0333	COG2890	protein-(glutamine-N5) methyltransferase activity
O23A_p0335	COG2912	Transglutaminase-like superfamily
O23A_p0337	COG1301	dicarboxylic acid transport
O23A_p0339	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O23A_p0342	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O23A_p0343	COG1115	amino acid carrier protein
O23A_p0346	COG0714	Associated with various cellular activities
O23A_p0349	COG0583	DNA-binding transcription factor activity
O23A_p0350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O23A_p0351	COG1678	Uncharacterized ACR, COG1678
O23A_p0353	COG0189	ligase activity
O23A_p0354	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O23A_p0356	COG3091	SprT-like family
O23A_p0358	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O23A_p0362	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O23A_p0363	COG0739	heme binding
O23A_p0364	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O23A_p0367	COG0463	Glycosyl transferase, family 2
O23A_p0370	COG2989	Protein conserved in bacteria
O23A_p0371	COG3108	Peptidase M15
O23A_p0373	COG2860	membrane
O23A_p0375	COG1196	nuclear chromosome segregation
O23A_p0376	COG3115	cell septum assembly
O23A_p0377	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O23A_p0379	COG1328	CTP reductase activity
O23A_p0380	COG0602	queuosine metabolic process
O23A_p0385	COG1566	PFAM secretion protein HlyD family protein
O23A_p0386	COG1846	Transcriptional regulator
O23A_p0391	COG0281	malic enzyme
O23A_p0392	COG3290	protein histidine kinase activity
O23A_p0395	COG0667	Aldo Keto reductase
O23A_p0397	COG0697	spore germination
O23A_p0399	COG1012	belongs to the aldehyde dehydrogenase family
O23A_p0400	COG3284	Transcriptional regulator
O23A_p0402	COG3706	GGDEF domain
O23A_p0403	COG0346	lactoylglutathione lyase activity
O23A_p0404	COG0745	RESPONSE REGULATOR receiver
O23A_p0405	COG5002	protein histidine kinase activity
O23A_p0407	COG4783	chaperone-mediated protein folding
O23A_p0409	COG1940	carbohydrate kinase activity
O23A_p0410	COG3142	Participates in the control of copper homeostasis
O23A_p0411	COG0545	Peptidyl-prolyl cis-trans isomerase
O23A_p0412	COG1131	(ABC) transporter
O23A_p0416	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O23A_p0420	COG0019	diaminopimelate decarboxylase activity
O23A_p0422	COG1115	amino acid carrier protein
O23A_p0423	COG0095	Lipoate-protein ligase
O23A_p0424	COG2233	PERMEase
O23A_p0425	COG3706	GGDEF domain
O23A_p0425	COG0745	RESPONSE REGULATOR receiver
O23A_p0427	COG0534	Mate efflux family protein
O23A_p0428	COG2207	Transcriptional regulator
O23A_p0429	COG0281	malic enzyme
O23A_p0430	COG2885	chlorophyll binding
O23A_p0430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
O23A_p0438	COG0733	neurotransmitter:sodium symporter activity
O23A_p0439	COG1752	Esterase of the alpha-beta hydrolase superfamily
O23A_p0440	COG3706	GGDEF domain
O23A_p0441	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p0442	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p0444	COG1032	radical SAM domain protein
O23A_p0450	COG0673	inositol 2-dehydrogenase activity
O23A_p0451	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O23A_p0452	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O23A_p0453	COG1196	nuclear chromosome segregation
O23A_p0453	COG0739	heme binding
O23A_p0453	COG0741	lytic transglycosylase activity
O23A_p0454	COG0366	Alpha amylase catalytic
O23A_p0458	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_p0460	COG0788	formyltetrahydrofolate deformylase activity
O23A_p0461	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O23A_p0464	COG3118	belongs to the thioredoxin family
O23A_p0465	COG2091	lysine biosynthetic process via aminoadipic acid
O23A_p0466	COG0791	NLP P60 protein
O23A_p0467	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
O23A_p0470	COG1388	LysM domain
O23A_p0470	COG1376	ErfK ybiS ycfS ynhG family protein
O23A_p0476	COG3501	Rhs element vgr protein
O23A_p0483	COG3311	Transcriptional regulator
O23A_p0497	COG2003	Belongs to the UPF0758 family
O23A_p0508	COG1518	maintenance of DNA repeat elements
O23A_p0509	COG1203	CRISPR-associated helicase, Cas3
O23A_p0519	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O23A_p0521	COG1960	acyl-CoA dehydrogenase activity
O23A_p0522	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p0524	COG0469	pyruvate kinase activity
O23A_p0525	COG1737	Transcriptional regulator
O23A_p0527	COG3290	protein histidine kinase activity
O23A_p0528	COG0745	RESPONSE REGULATOR receiver
O23A_p0529	COG2274	protein secretion by the type I secretion system
O23A_p0531	COG2274	protein secretion by the type I secretion system
O23A_p0533	COG2994	toxin metabolic process
O23A_p0534	COG1073	alpha beta
O23A_p0534	COG3064	Membrane
O23A_p0534	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O23A_p0537	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O23A_p0540	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p0542	COG1414	Transcriptional regulator
O23A_p0543	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_p0544	COG0800	Aldolase
O23A_p0545	COG2731	YhcH YjgK YiaL family protein
O23A_p0550	COG1342	Belongs to the UPF0251 family
O23A_p0553	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O23A_p0555	COG1677	Flagellar hook-basal body complex protein FliE
O23A_p0557	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O23A_p0567	COG1987	bacterial-type flagellum assembly
O23A_p0568	COG1684	flagellar biosynthetic protein fliR
O23A_p0570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O23A_p0572	COG0455	bacterial-type flagellum organization
O23A_p0575	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O23A_p0576	COG2198	Histidine kinase
O23A_p0576	COG0643	Histidine kinase
O23A_p0577	COG2201	protein-glutamate methylesterase activity
O23A_p0578	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_p0579	COG1360	Flagellar Motor Protein
O23A_p0580	COG1192	Involved in chromosome partitioning
O23A_p0582	COG0835	chemotaxis
O23A_p0585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_p0586	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_p0587	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_p0588	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O23A_p0589	COG1138	Cytochrome C-type biogenesis protein
O23A_p0590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O23A_p0591	COG3088	subunit of a heme lyase
O23A_p0591	COG4235	cytochrome complex assembly
O23A_p0592	COG3088	subunit of a heme lyase
O23A_p0592	COG4235	cytochrome complex assembly
O23A_p0595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O23A_p0596	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_p0596	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_p0599	COG0259	pyridoxamine-phosphate oxidase activity
O23A_p0602	COG3153	acetyltransferase
O23A_p0606	COG2850	peptidyl-arginine hydroxylation
O23A_p0607	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O23A_p0608	COG2915	High frequency lysogenization protein hflD homolog
O23A_p0610	COG0482	sulfurtransferase activity
O23A_p0615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p0619	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p0619	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p0619	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p0624	COG0783	Belongs to the Dps family
O23A_p0627	COG1988	membrane-bound metal-dependent
O23A_p0632	COG0159	tryptophan synthase activity
O23A_p0633	COG0133	tryptophan synthase activity
O23A_p0634	COG0135	phosphoribosylanthranilate isomerase activity
O23A_p0634	COG0134	indole-3-glycerol-phosphate synthase activity
O23A_p0635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O23A_p0636	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O23A_p0636	COG0512	Glutamine amidotransferase of anthranilate synthase
O23A_p0637	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O23A_p0640	COG0613	PHP domain protein
O23A_p0641	COG0009	L-threonylcarbamoyladenylate synthase
O23A_p0643	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O23A_p0646	COG1946	Acyl-CoA thioesterase
O23A_p0649	COG1309	transcriptional regulator
O23A_p0650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p0651	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p0652	COG1538	Outer membrane efflux protein
O23A_p0654	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O23A_p0666	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O23A_p0668	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_p0673	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
O23A_p0675	COG3132	Protein of unknown function, DUF480
O23A_p0684	COG1278	Cold shock
O23A_p0689	COG4166	transmembrane transport
O23A_p0690	COG0697	spore germination
O23A_p0693	COG1187	pseudouridine synthase activity
O23A_p0696	COG4166	transmembrane transport
O23A_p0697	COG0622	Phosphoesterase
O23A_p0701	COG0835	chemotaxis
O23A_p0701	COG0784	Response regulator, receiver
O23A_p0702	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O23A_p0703	COG1815	bacterial-type flagellum-dependent cell motility
O23A_p0704	COG1558	bacterial-type flagellum-dependent cell motility
O23A_p0707	COG4787	bacterial-type flagellum-dependent cell motility
O23A_p0708	COG4786	Flagellar basal body rod
O23A_p0709	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O23A_p0710	COG1706	bacterial-type flagellum-dependent cell motility
O23A_p0714	COG2239	Acts as a magnesium transporter
O23A_p0715	COG0248	Ppx GppA phosphatase
O23A_p0716	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O23A_p0719	COG2204	response regulator
O23A_p0720	COG3852	Histidine kinase
O23A_p0721	COG2204	response regulator
O23A_p0722	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O23A_p0723	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O23A_p0724	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O23A_p0725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O23A_p0729	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O23A_p0732	COG0590	tRNA wobble adenosine to inosine editing
O23A_p0733	COG0573	inorganic phosphate transmembrane transporter activity
O23A_p0734	COG0581	inorganic phosphate transmembrane transporter activity
O23A_p0737	COG0704	Plays a role in the regulation of phosphate uptake
O23A_p0738	COG1253	flavin adenine dinucleotide binding
O23A_p0741	COG0531	amino acid
O23A_p0743	COG1126	abc transporter atp-binding protein
O23A_p0744	COG0765	amino acid transport
O23A_p0745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p0746	COG3706	GGDEF domain
O23A_p0747	COG2271	Major facilitator Superfamily
O23A_p0750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O23A_p0755	COG1785	Belongs to the alkaline phosphatase family
O23A_p0757	COG0123	including yeast histone deacetylase and acetoin utilization protein
O23A_p0759	COG1199	ATP-dependent helicase activity
O23A_p0762	COG1448	Aminotransferase
O23A_p0763	COG0433	COG0433 Predicted ATPase
O23A_p0766	COG2333	competence protein COMEC
O23A_p0766	COG0658	competence protein
O23A_p0767	COG1132	(ABC) transporter
O23A_p0768	COG1663	tetraacyldisaccharide 4'-kinase activity
O23A_p0769	COG2835	tetraacyldisaccharide 4'-kinase activity
O23A_p0770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O23A_p0771	COG2197	response regulator
O23A_p0772	COG0322	excinuclease ABC activity
O23A_p0792	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O23A_p0802	COG4695	Portal protein
O23A_p0821	COG4974	Belongs to the 'phage' integrase family
O23A_p0831	COG2261	transglycosylase associated protein
O23A_p0832	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_p0834	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O23A_p0842	COG2203	Gaf domain
O23A_p0842	COG2199	diguanylate cyclase activity
O23A_p0848	COG2119	membrane
O23A_p0849	COG0023	Translation Initiation Factor
O23A_p0857	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p0857	COG2205	protein histidine kinase activity
O23A_p0859	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
O23A_p0861	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_p0862	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O23A_p0863	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O23A_p0864	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O23A_p0865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O23A_p0869	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O23A_p0871	COG0505	Belongs to the CarA family
O23A_p0872	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O23A_p0874	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O23A_p0876	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O23A_p0880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p0881	COG0513	Belongs to the DEAD box helicase family
O23A_p0883	COG4104	PAAR repeat-containing protein
O23A_p0886	COG0789	Transcriptional regulator
O23A_p0889	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p0890	COG0765	amino acid transport
O23A_p0891	COG1126	abc transporter atp-binding protein
O23A_p0892	COG0493	'glutamate synthase
O23A_p0893	COG0069	glutamate synthase activity
O23A_p0893	COG0070	glutamate synthase
O23A_p0893	COG0067	glutamate synthase
O23A_p0894	COG1242	4 iron, 4 sulfur cluster binding
O23A_p0908	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O23A_p0909	COG0574	Belongs to the PEP-utilizing enzyme family
O23A_p0909	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O23A_p0917	COG1464	Belongs to the NlpA lipoprotein family
O23A_p0918	COG0671	phosphoesterase, PA-phosphatase related
O23A_p0919	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O23A_p0920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O23A_p0922	COG0101	tRNA pseudouridine synthase activity
O23A_p0923	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O23A_p0924	COG0285	dihydrofolate synthase activity
O23A_p0925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
O23A_p0926	COG2920	part of a sulfur-relay system
O23A_p0927	COG1289	transmembrane transporter activity
O23A_p0928	COG0670	Belongs to the BI1 family
O23A_p0929	COG0840	transmembrane signaling receptor activity
O23A_p0930	COG5001	Diguanylate cyclase
O23A_p0931	COG0564	pseudouridine synthase activity
O23A_p0934	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O23A_p0936	COG0625	glutathione transferase activity
O23A_p0938	COG0367	asparagine synthase
O23A_p0940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O23A_p0940	COG4651	solute:proton antiporter activity
O23A_p0941	COG0647	UMP catabolic process
O23A_p0942	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O23A_p0943	COG1902	pentaerythritol trinitrate reductase activity
O23A_p0944	COG1253	flavin adenine dinucleotide binding
O23A_p0947	COG0277	FAD linked oxidase domain protein
O23A_p0947	COG0247	lactate metabolic process
O23A_p0949	COG2050	protein possibly involved in aromatic compounds catabolism
O23A_p0950	COG0513	Belongs to the DEAD box helicase family
O23A_p0952	COG3300	MHYT domain
O23A_p0952	COG5001	Diguanylate cyclase
O23A_p0953	COG2056	Na+-H+ antiporter family
O23A_p0954	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O23A_p0957	COG0346	lactoylglutathione lyase activity
O23A_p0958	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O23A_p0960	COG4659	FMN binding
O23A_p0961	COG4658	electron transport chain
O23A_p0963	COG2878	Part of a membrane complex involved in electron transport
O23A_p0964	COG4657	Part of a membrane complex involved in electron transport
O23A_p0965	COG0697	spore germination
O23A_p0968	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O23A_p0969	COG1288	antiporter activity
O23A_p0970	COG0436	Aminotransferase
O23A_p0972	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O23A_p0974	COG2027	D-alanyl-D-alanine carboxypeptidase
O23A_p0975	COG1061	Type III restriction enzyme res subunit
O23A_p0976	COG1566	PFAM secretion protein HlyD family protein
O23A_p0979	COG1966	Carbon starvation protein
O23A_p0980	COG3279	Response regulator of the LytR AlgR family
O23A_p0981	COG3275	phosphorelay sensor kinase activity
O23A_p0983	COG1012	belongs to the aldehyde dehydrogenase family
O23A_p0983	COG1454	alcohol dehydrogenase
O23A_p0985	COG2095	MarC family integral membrane protein
O23A_p0987	COG0601	transmembrane transport
O23A_p0988	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_p0989	COG0444	Belongs to the ABC transporter superfamily
O23A_p0991	COG0861	Integral membrane protein TerC family
O23A_p0992	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_p0994	COG1301	dicarboxylic acid transport
O23A_p0996	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O23A_p0999	COG0537	adenosine 5'-monophosphoramidase activity
O23A_p1006	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_p1007	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_p1012	COG1007	ATP synthesis coupled electron transport
O23A_p1013	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1015	COG0713	ATP synthesis coupled electron transport
O23A_p1016	COG0839	Belongs to the complex I subunit 6 family
O23A_p1017	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1018	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O23A_p1019	COG1034	ATP synthesis coupled electron transport
O23A_p1022	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1022	COG0649	NAD binding
O23A_p1023	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1024	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1025	COG1360	Flagellar Motor Protein
O23A_p1026	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_p1028	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O23A_p1031	COG4597	amino acid ABC transporter
O23A_p1032	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p1033	COG0765	amino acid transport
O23A_p1034	COG1126	abc transporter atp-binding protein
O23A_p1037	COG0724	RNA recognition motif
O23A_p1038	COG4989	oxidoreductase activity
O23A_p1043	COG3437	response regulator, receiver
O23A_p1044	COG0583	DNA-binding transcription factor activity
O23A_p1046	COG5001	Diguanylate cyclase
O23A_p1046	COG3300	MHYT domain
O23A_p1053	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O23A_p1054	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O23A_p1055	COG0539	negative regulation of cytoplasmic translation
O23A_p1056	COG0776	regulation of translation
O23A_p1058	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O23A_p1059	COG0284	orotidine-5'-phosphate decarboxylase activity
O23A_p1062	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O23A_p1063	COG0602	queuosine metabolic process
O23A_p1064	COG3530	Putative quorum-sensing-regulated virulence factor
O23A_p1065	COG2096	Adenosyltransferase
O23A_p1066	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_p1068	COG1757	Na H antiporter
O23A_p1069	COG1435	thymidine kinase activity
O23A_p1072	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_p1076	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
O23A_p1077	COG0437	4 iron, 4 sulfur cluster binding
O23A_p1078	COG5557	Pfam Polysulphide reductase, NrfD
O23A_p1079	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
O23A_p1080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O23A_p1081	COG1773	rubredoxin
O23A_p1083	COG0601	transmembrane transport
O23A_p1084	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_p1086	COG1124	(ABC) transporter
O23A_p1087	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O23A_p1089	COG0375	protein maturation
O23A_p1090	COG0309	Hydrogenase expression formation protein (HypE)
O23A_p1092	COG0298	carbon dioxide binding
O23A_p1093	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
O23A_p1095	COG1921	L-seryl-tRNASec selenium transferase activity
O23A_p1096	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O23A_p1098	COG3260	NADH ubiquinone oxidoreductase 20
O23A_p1099	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_p1100	COG3261	NADH dehydrogenase
O23A_p1100	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
O23A_p1101	COG0650	Formate hydrogenlyase subunit 4
O23A_p1102	COG0651	ATP synthesis coupled electron transport
O23A_p1103	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_p1104	COG3158	transport of potassium into the cell
O23A_p1107	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_p1108	COG3383	formate dehydrogenase (NAD+) activity
O23A_p1109	COG3383	formate dehydrogenase (NAD+) activity
O23A_p1113	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O23A_p1114	COG0326	Molecular chaperone. Has ATPase activity
O23A_p1116	COG0563	adenylate kinase activity
O23A_p1117	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O23A_p1118	COG3788	relative of glutathione S-transferase, MAPEG superfamily
O23A_p1119	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_p1120	COG0840	transmembrane signaling receptor activity
O23A_p1123	COG3300	MHYT domain
O23A_p1123	COG5001	Diguanylate cyclase
O23A_p1124	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O23A_p1128	COG1021	2,3-dihydroxybenzoate-AMP ligase
O23A_p1129	COG1535	isochorismatase
O23A_p1129	COG3433	isochorismatase activity
O23A_p1130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_p1131	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p1133	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p1133	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_p1133	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p1133	COG0300	oxidoreductase activity
O23A_p1133	COG3321	synthase
O23A_p1135	COG2977	Belongs to the P-Pant transferase superfamily
O23A_p1136	COG1120	ATPase activity
O23A_p1137	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_p1138	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_p1139	COG4771	TonB-dependent receptor
O23A_p1143	COG0598	Magnesium transport protein CorA
O23A_p1145	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
O23A_p1145	COG0644	oxidoreductase
O23A_p1149	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O23A_p1150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O23A_p1151	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_p1154	COG1570	exodeoxyribonuclease VII activity
O23A_p1155	COG3038	cytochrome b561
O23A_p1159	COG0517	IMP dehydrogenase activity
O23A_p1159	COG0516	GMP reductase activity
O23A_p1160	COG0519	Catalyzes the synthesis of GMP from XMP
O23A_p1160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O23A_p1166	COG2062	phosphohistidine phosphatase, SixA
O23A_p1168	COG0697	spore germination
O23A_p1169	COG4166	transmembrane transport
O23A_p1170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O23A_p1171	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O23A_p1173	COG4591	ABC-type transport system involved in lipoprotein release permease component
O23A_p1174	COG1136	(ABC) transporter
O23A_p1175	COG4591	ABC-type transport system involved in lipoprotein release permease component
O23A_p1176	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
O23A_p1178	COG0544	peptidyl-prolyl cis-trans isomerase activity
O23A_p1179	COG0740	serine-type endopeptidase activity
O23A_p1180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O23A_p1181	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O23A_p1183	COG0776	regulation of translation
O23A_p1184	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O23A_p1185	COG0488	(ABC) transporter
O23A_p1186	COG0582	viral genome integration into host DNA
O23A_p1190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O23A_p1190	COG0784	Response regulator, receiver
O23A_p1202	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O23A_p1203	COG3162	membrane
O23A_p1206	COG1024	Enoyl-CoA hydratase
O23A_p1206	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_p1207	COG1115	amino acid carrier protein
O23A_p1210	COG1584	GPR1 FUN34 yaaH family protein
O23A_p1218	COG1024	Enoyl-CoA hydratase
O23A_p1219	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O23A_p1220	COG1960	acyl-CoA dehydrogenase activity
O23A_p1222	COG1960	acyl-CoA dehydrogenase activity
O23A_p1223	COG1024	Enoyl-CoA hydratase
O23A_p1224	COG1024	Enoyl-CoA hydratase
O23A_p1227	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p1229	COG0730	response to heat
O23A_p1242	COG2823	Periplasmic or secreted lipoprotein
O23A_p1244	COG3706	GGDEF domain
O23A_p1244	COG2203	Gaf domain
O23A_p1244	COG4251	negative regulation of phosphorylation
O23A_p1244	COG5001	Diguanylate cyclase
O23A_p1245	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_p1246	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_p1247	COG1129	ABC transporter
O23A_p1248	COG1879	ABC-type sugar transport system periplasmic component
O23A_p1250	COG0583	DNA-binding transcription factor activity
O23A_p1252	COG2723	6-phospho-beta-galactosidase activity
O23A_p1255	COG0583	DNA-binding transcription factor activity
O23A_p1256	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O23A_p1257	COG0673	inositol 2-dehydrogenase activity
O23A_p1258	COG0583	DNA-binding transcription factor activity
O23A_p1260	COG1560	Kdo2-lipid A biosynthetic process
O23A_p1262	COG1560	Kdo2-lipid A biosynthetic process
O23A_p1265	COG2203	Gaf domain
O23A_p1265	COG2199	diguanylate cyclase activity
O23A_p1268	COG0417	DNA replication proofreading
O23A_p1270	COG0534	Mate efflux family protein
O23A_p1272	COG0307	riboflavin synthase, alpha
O23A_p1274	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_p1275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O23A_p1276	COG0697	spore germination
O23A_p1277	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O23A_p1286	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O23A_p1288	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O23A_p1289	COG2894	cell division
O23A_p1290	COG0850	regulation of cytokinetic process
O23A_p1291	COG3100	YcgL domain-containing protein
O23A_p1292	COG2951	lytic endotransglycosylase activity
O23A_p1293	COG1760	l-serine dehydratase
O23A_p1295	COG1760	l-serine dehydratase
O23A_p1296	COG3123	guanosine phosphorylase activity
O23A_p1300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O23A_p1301	COG2067	long-chain fatty acid transport protein
O23A_p1302	COG2067	long-chain fatty acid transport protein
O23A_p1311	COG0714	Associated with various cellular activities
O23A_p1312	COG0183	Belongs to the thiolase family
O23A_p1313	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_p1313	COG1024	Enoyl-CoA hydratase
O23A_p1314	COG2824	Alkylphosphonate utilization operon protein PhnA
O23A_p1321	COG3706	GGDEF domain
O23A_p1322	COG2840	Smr protein MutS2
O23A_p1323	COG2890	protein-(glutamine-N5) methyltransferase activity
O23A_p1324	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O23A_p1327	COG0513	Belongs to the DEAD box helicase family
O23A_p1328	COG5654	RES domain protein
O23A_p1330	COG0814	amino acid
O23A_p1331	COG1609	Transcriptional regulator
O23A_p1332	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p1332	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p1333	COG1105	Belongs to the carbohydrate kinase PfkB family
O23A_p1334	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O23A_p1334	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p1334	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p1335	COG3313	Fe-S protein
O23A_p1336	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
O23A_p1337	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O23A_p1338	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_p1339	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_p1342	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O23A_p1348	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O23A_p1349	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O23A_p1350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O23A_p1351	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O23A_p1352	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O23A_p1353	COG0072	phenylalanine-tRNA ligase activity
O23A_p1353	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_p1354	COG0776	regulation of translation
O23A_p1355	COG0784	Response regulator, receiver
O23A_p1355	COG2205	protein histidine kinase activity
O23A_p1358	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O23A_p1360	COG2199	diguanylate cyclase activity
O23A_p1361	COG1609	Transcriptional regulator
O23A_p1362	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_p1363	COG1879	ABC-type sugar transport system periplasmic component
O23A_p1364	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_p1365	COG1129	ABC transporter
O23A_p1366	COG1869	D-ribose catabolic process
O23A_p1367	COG0625	glutathione transferase activity
O23A_p1370	COG0037	tRNA processing
O23A_p1371	COG0589	response to stress
O23A_p1372	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O23A_p1375	COG2217	Heavy metal translocating P-type atpase
O23A_p1377	COG2010	Cytochrome c
O23A_p1380	COG3278	Belongs to the heme-copper respiratory oxidase family
O23A_p1382	COG1956	GAF domain-containing protein
O23A_p1383	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
O23A_p1384	COG0793	Belongs to the peptidase S41A family
O23A_p1385	COG0308	aminopeptidase N
O23A_p1387	COG2902	Dehydrogenase
O23A_p1388	COG0167	dihydroorotate dehydrogenase activity
O23A_p1390	COG0116	Belongs to the methyltransferase superfamily
O23A_p1390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O23A_p1394	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O23A_p1395	COG1067	ATP-dependent peptidase activity
O23A_p1409	COG3141	response to X-ray
O23A_p1411	COG4221	oxidoreductase activity
O23A_p1420	COG0372	Belongs to the citrate synthase family
O23A_p1421	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O23A_p1423	COG2995	paraquat-inducible protein a
O23A_p1424	COG3008	intermembrane lipid transfer
O23A_p1425	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
O23A_p1425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_p1429	COG0084	hydrolase, TatD family'
O23A_p1430	COG0470	DNA polymerase III
O23A_p1431	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O23A_p1432	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O23A_p1433	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O23A_p1434	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_p1435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_p1436	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p1438	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O23A_p1439	COG0416	fatty acid biosynthetic process
O23A_p1440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O23A_p1441	COG1399	metal-binding, possibly nucleic acid-binding protein
O23A_p1442	COG0424	maF-like protein
O23A_p1443	COG0546	phosphoglycolate phosphatase activity
O23A_p1445	COG1530	ribonuclease E activity
O23A_p1447	COG0306	phosphate transporter
O23A_p1448	COG0717	Belongs to the dCTP deaminase family
O23A_p1449	COG0572	uridine kinase
O23A_p1450	COG0489	protein tyrosine kinase activity
O23A_p1451	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_p1451	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_p1452	COG0625	glutathione transferase activity
O23A_p1453	COG1254	Belongs to the acylphosphatase family
O23A_p1454	COG0840	transmembrane signaling receptor activity
O23A_p1455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O23A_p1458	COG0709	Synthesizes selenophosphate from selenide and ATP
O23A_p1459	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
O23A_p1460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O23A_p1461	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O23A_p1463	COG1643	Atp-dependent helicase
O23A_p1465	COG2197	response regulator
O23A_p1467	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O23A_p1468	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O23A_p1469	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O23A_p1470	COG2832	Protein of unknown function (DUF454)
O23A_p1471	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O23A_p1475	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p1476	COG2267	carboxylic ester hydrolase activity
O23A_p1478	COG1214	PFAM Peptidase M22, glycoprotease
O23A_p1479	COG1199	ATP-dependent helicase activity
O23A_p1481	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O23A_p1482	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O23A_p1484	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O23A_p1485	COG0131	Imidazoleglycerol-phosphate dehydratase
O23A_p1485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O23A_p1487	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O23A_p1488	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O23A_p1489	COG3437	response regulator, receiver
O23A_p1491	COG2205	protein histidine kinase activity
O23A_p1491	COG2198	Histidine kinase
O23A_p1491	COG0784	Response regulator, receiver
O23A_p1492	COG0107	imidazoleglycerol-phosphate synthase activity
O23A_p1493	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O23A_p1493	COG0140	phosphoribosyl-ATP diphosphatase activity
O23A_p1495	COG2378	regulation of single-species biofilm formation
O23A_p1496	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p1498	COG1288	antiporter activity
O23A_p1500	COG3134	Outer membrane lipoprotein
O23A_p1504	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_p1508	COG4681	YaeQ
O23A_p1517	COG0242	peptide deformylase activity
O23A_p1522	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O23A_p1523	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
O23A_p1525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O23A_p1526	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O23A_p1528	COG0205	6-phosphofructokinase activity
O23A_p1533	COG1473	amidohydrolase
O23A_p1534	COG1011	Hydrolase
O23A_p1535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_p1538	COG3593	DNA synthesis involved in DNA repair
O23A_p1541	COG0583	DNA-binding transcription factor activity
O23A_p1542	COG0730	response to heat
O23A_p1545	COG1181	Belongs to the D-alanine--D-alanine ligase family
O23A_p1547	COG0386	Belongs to the glutathione peroxidase family
O23A_p1548	COG0513	Belongs to the DEAD box helicase family
O23A_p1552	COG1742	UPF0060 membrane protein
O23A_p1559	COG2329	Antibiotic biosynthesis monooxygenase
O23A_p1560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O23A_p1564	COG3243	poly(R)-hydroxyalkanoic acid synthase
O23A_p1566	COG2501	S4 domain
O23A_p1568	COG1132	(ABC) transporter
O23A_p1569	COG1132	(ABC) transporter
O23A_p1571	COG3118	belongs to the thioredoxin family
O23A_p1572	COG0471	metal ion transport
O23A_p1573	COG0058	SHG alpha-glucan phosphorylase activity
O23A_p1578	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O23A_p1580	COG0814	amino acid
O23A_p1581	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O23A_p1582	COG0514	ATP-dependent DNA helicase (RecQ)
O23A_p1583	COG2766	serine protein kinase
O23A_p1585	COG2719	SpoVR family
O23A_p1587	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_p1588	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O23A_p1589	COG0586	Pfam SNARE associated Golgi protein
O23A_p1591	COG0556	nucleotide-excision repair
O23A_p1592	COG2985	domain, Protein
O23A_p1592	COG0569	domain protein
O23A_p1593	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_p1597	COG4565	transcriptional regulatory protein
O23A_p1598	COG3290	protein histidine kinase activity
O23A_p1599	COG1846	Transcriptional regulator
O23A_p1599	COG1940	carbohydrate kinase activity
O23A_p1600	COG0840	transmembrane signaling receptor activity
O23A_p1601	COG3012	SEC-C Motif Domain Protein
O23A_p1602	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O23A_p1603	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
O23A_p1604	COG0247	lactate metabolic process
O23A_p1606	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
O23A_p1607	COG0437	4 iron, 4 sulfur cluster binding
O23A_p1608	COG3301	Polysulphide reductase, NrfD
O23A_p1609	COG1138	Cytochrome C-type biogenesis protein
O23A_p1611	COG4235	cytochrome complex assembly
O23A_p1611	COG3088	subunit of a heme lyase
O23A_p1614	COG3033	Beta-eliminating lyase
O23A_p1615	COG3046	protein related to deoxyribodipyrimidine photolyase
O23A_p1616	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_p1621	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O23A_p1622	COG0583	DNA-binding transcription factor activity
O23A_p1624	COG4774	siderophore transport
O23A_p1625	COG2207	Transcriptional regulator
O23A_p1625	COG3708	Transcriptional regulator
O23A_p1628	COG0583	DNA-binding transcription factor activity
O23A_p1629	COG2910	NAD(P)H-binding
O23A_p1632	COG0612	Peptidase, M16
O23A_p1633	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O23A_p1634	COG1944	ATP diphosphatase activity
O23A_p1635	COG2116	formate transmembrane transporter activity
O23A_p1636	COG1882	Formate acetyltransferase
O23A_p1639	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O23A_p1640	COG0045	succinate-CoA ligase (ADP-forming) activity
O23A_p1641	COG0508	dehydrogenase complex catalyzes the overall conversion of
O23A_p1642	COG0567	Dehydrogenase, E1 component
O23A_p1644	COG1053	succinate dehydrogenase
O23A_p1645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O23A_p1646	COG2009	succinate dehydrogenase
O23A_p1651	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_p1652	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
O23A_p1652	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_p1654	COG3069	C4-dicarboxylate transmembrane transporter activity
O23A_p1657	COG1451	nucleotide metabolic process
O23A_p1660	COG0254	rRNA binding
O23A_p1661	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O23A_p1663	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_p1664	COG1129	ABC transporter
O23A_p1665	COG1879	ABC-type sugar transport system periplasmic component
O23A_p1666	COG1069	ribulokinase activity
O23A_p1668	COG2160	L-arabinose isomerase activity
O23A_p1669	COG0583	DNA-binding transcription factor activity
O23A_p1670	COG0436	Aminotransferase
O23A_p1671	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_p1674	COG2925	Exonuclease
O23A_p1676	COG3345	alpha-galactosidase
O23A_p1678	COG1380	Effector of murein hydrolase LrgA
O23A_p1679	COG1346	cytolysis
O23A_p1681	COG0295	cytidine deaminase activity
O23A_p1682	COG1022	Amp-dependent synthetase and ligase
O23A_p1685	COG0861	Integral membrane protein TerC family
O23A_p1687	COG2199	diguanylate cyclase activity
O23A_p1690	COG2154	pterin-4-alpha-carbinolamine dehydratase
O23A_p1692	COG3768	UPF0283 membrane protein
O23A_p1693	COG3106	COG3106 Predicted ATPase
O23A_p1696	COG1842	Phage shock protein A
O23A_p1697	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O23A_p1699	COG4168	peptide transport system, permease
O23A_p1700	COG4171	peptide transport system, permease
O23A_p1701	COG4172	Belongs to the ABC transporter superfamily
O23A_p1702	COG4172	Belongs to the ABC transporter superfamily
O23A_p1704	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O23A_p1705	COG1286	toxin biosynthetic process
O23A_p1706	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O23A_p1707	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O23A_p1709	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O23A_p1710	COG1674	ftsk spoiiie
O23A_p1710	COG0531	amino acid
O23A_p1712	COG0686	Belongs to the AlaDH PNT family
O23A_p1713	COG0492	ferredoxin-NADP+ reductase activity
O23A_p1714	COG3706	GGDEF domain
O23A_p1715	COG3134	Outer membrane lipoprotein
O23A_p1716	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O23A_p1717	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O23A_p1718	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O23A_p1719	COG0542	response to heat
O23A_p1720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O23A_p1721	COG1278	Cold shock
O23A_p1722	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O23A_p1725	COG3501	Rhs element vgr protein
O23A_p1748	COG3501	Rhs element vgr protein
O23A_p1750	COG0659	secondary active sulfate transmembrane transporter activity
O23A_p1756	COG0672	)-iron permease
O23A_p1757	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
O23A_p1761	COG2814	Major facilitator Superfamily
O23A_p1764	COG1136	(ABC) transporter
O23A_p1775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O23A_p1777	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O23A_p1777	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O23A_p1778	COG0527	aspartate kinase activity
O23A_p1780	COG1368	sulfuric ester hydrolase activity
O23A_p1781	COG1619	proteins homologs of microcin C7 resistance protein MccF
O23A_p1783	COG0393	Putative heavy-metal-binding
O23A_p1784	COG1252	NADH dehydrogenase
O23A_p1789	COG2354	Protein conserved in bacteria
O23A_p1791	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O23A_p1791	COG0047	phosphoribosylformylglycinamidine synthase activity
O23A_p1792	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_p1793	COG1645	bacterial-type flagellum-dependent swarming motility
O23A_p1794	COG1160	GTP binding
O23A_p1795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_p1796	COG2976	Protein conserved in bacteria
O23A_p1797	COG0124	histidyl-tRNA synthetase
O23A_p1799	COG1426	Protein conserved in bacteria
O23A_p1801	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O23A_p1802	COG0105	UTP biosynthetic process
O23A_p1803	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_p1805	COG0633	Ferredoxin
O23A_p1806	COG0443	Heat shock 70 kDa protein
O23A_p1807	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O23A_p1810	COG0822	iron-sulfur transferase activity
O23A_p1811	COG1104	cysteine desulfurase activity
O23A_p1812	COG1959	2 iron, 2 sulfur cluster binding
O23A_p1818	COG2897	thiosulfate sulfurtransferase activity
O23A_p1819	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_p1820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_p1821	COG1862	Preprotein translocase
O23A_p1822	COG0343	queuine tRNA-ribosyltransferase activity
O23A_p1823	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O23A_p1824	COG0517	IMP dehydrogenase activity
O23A_p1825	COG0450	alkyl hydroperoxide reductase
O23A_p1826	COG3634	alkyl hydroperoxide reductase activity
O23A_p1829	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O23A_p1829	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O23A_p1830	COG0509	glycine decarboxylation via glycine cleavage system
O23A_p1831	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O23A_p1832	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_p1833	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_p1837	COG0243	molybdopterin cofactor binding
O23A_p1838	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O23A_p1839	COG0583	DNA-binding transcription factor activity
O23A_p1840	COG2814	Major facilitator Superfamily
O23A_p1841	COG0444	Belongs to the ABC transporter superfamily
O23A_p1842	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_p1843	COG0601	transmembrane transport
O23A_p1845	COG0625	glutathione transferase activity
O23A_p1847	COG0483	inositol monophosphate 1-phosphatase activity
O23A_p1851	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O23A_p1853	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O23A_p1860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O23A_p1863	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_p1863	COG0301	tRNA thio-modification
O23A_p1865	COG4953	penicillin-binding protein 1C
O23A_p1866	COG2373	Large extracellular alpha-helical protein
O23A_p1867	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_p1869	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O23A_p1877	COG1215	transferase activity, transferring glycosyl groups
O23A_p1877	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O23A_p1882	COG4215	(ABC) transporter
O23A_p1885	COG2431	L-lysine efflux transmembrane transporter activity
O23A_p1886	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
O23A_p1888	COG1393	Belongs to the ArsC family
O23A_p1890	COG4783	chaperone-mediated protein folding
O23A_p1891	COG0425	Belongs to the sulfur carrier protein TusA family
O23A_p1892	COG0628	permease
O23A_p1895	COG3842	ATPase activity
O23A_p1897	COG1175	transmembrane transport
O23A_p1898	COG2182	Extracellular solute-binding protein
O23A_p1899	COG3081	Nucleoid-associated protein
O23A_p1900	COG3082	Protein of unknown function (DUF1414)
O23A_p1901	COG3083	sulfuric ester hydrolase activity
O23A_p1902	COG4771	TonB-dependent receptor
O23A_p1903	COG1770	oligopeptidase
O23A_p1907	COG4574	serine-type endopeptidase inhibitor activity
O23A_p1908	COG3085	chromosome segregation
O23A_p1909	COG0583	DNA-binding transcription factor activity
O23A_p1910	COG1605	Chorismate mutase
O23A_p1910	COG0287	Prephenate dehydrogenase
O23A_p1911	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_p1912	COG0584	glycerophosphoryl diester phosphodiesterase
O23A_p1913	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O23A_p1914	COG1349	DNA-binding transcription factor activity
O23A_p1915	COG2271	Major facilitator Superfamily
O23A_p1916	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O23A_p1917	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O23A_p1918	COG0583	DNA-binding transcription factor activity
O23A_p1921	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O23A_p1922	COG0656	L-ascorbic acid biosynthetic process
O23A_p1923	COG2814	Major facilitator Superfamily
O23A_p1926	COG3220	belongs to the UPF0276 family
O23A_p1930	COG1294	oxidase, subunit
O23A_p1932	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_p1934	COG2979	Protein of unknown function (DUF533)
O23A_p1938	COG0583	DNA-binding transcription factor activity
O23A_p1940	COG2807	transmembrane transport
O23A_p1941	COG1187	pseudouridine synthase activity
O23A_p1943	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O23A_p1945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
O23A_p1948	COG1403	HNH endonuclease
O23A_p1952	COG1166	arginine decarboxylase activity
O23A_p1955	COG2195	Cleaves the N-terminal amino acid of tripeptides
O23A_p1960	COG2353	YceI-like domain
O23A_p1961	COG0583	DNA-binding transcription factor activity
O23A_p1963	COG2759	Belongs to the formate--tetrahydrofolate ligase family
O23A_p1964	COG0840	transmembrane signaling receptor activity
O23A_p1965	COG0302	gtp cyclohydrolase
O23A_p1966	COG0303	'Molybdopterin
O23A_p1967	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O23A_p1968	COG0596	Alpha beta hydrolase
O23A_p1969	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O23A_p1972	COG0314	molybdopterin synthase activity
O23A_p1975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O23A_p1976	COG0315	cyclic pyranopterin monophosphate synthase activity
O23A_p1977	COG0521	Mo-molybdopterin cofactor biosynthetic process
O23A_p1978	COG3005	denitrification pathway
O23A_p1980	COG0348	domain, Protein
O23A_p1981	COG0437	4 iron, 4 sulfur cluster binding
O23A_p1982	COG0243	molybdopterin cofactor binding
O23A_p1984	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_p1985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O23A_p1986	COG3850	Histidine kinase
O23A_p1987	COG2197	response regulator
O23A_p1994	COG0121	glutamine amidotransferase
O23A_p1995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O23A_p1996	COG1960	acyl-CoA dehydrogenase activity
O23A_p1998	COG3437	response regulator, receiver
O23A_p1998	COG0784	Response regulator, receiver
O23A_p2000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O23A_p2001	COG0328	RNA-DNA hybrid ribonuclease activity
O23A_p2002	COG2226	methyltransferase
O23A_p2003	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O23A_p2004	COG1388	LysM domain
O23A_p2004	COG0741	lytic transglycosylase activity
O23A_p2005	COG3021	interspecies interaction between organisms
O23A_p2007	COG1607	acyl-coa hydrolase
O23A_p2013	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O23A_p2015	COG2911	Protein conserved in bacteria
O23A_p2016	COG0729	surface antigen
O23A_p2021	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O23A_p2022	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O23A_p2024	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O23A_p2026	COG4134	Bacterial extracellular solute-binding protein
O23A_p2027	COG4135	transport system, permease component
O23A_p2028	COG4136	ATPase activity
O23A_p2029	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O23A_p2030	COG2951	lytic endotransglycosylase activity
O23A_p2031	COG1846	Transcriptional regulator
O23A_p2033	COG0033	Phosphoglucomutase
O23A_p2034	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
O23A_p2035	COG0596	Alpha beta hydrolase
O23A_p2038	COG0716	FMN binding
O23A_p2040	COG0735	belongs to the Fur family
O23A_p2041	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_p2044	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_p2044	COG1263	PTS System
O23A_p2044	COG2190	(PTS) system
O23A_p2045	COG0363	glucosamine-6-phosphate deaminase activity
O23A_p2046	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O23A_p2047	COG1846	Transcriptional regulator
O23A_p2047	COG1940	carbohydrate kinase activity
O23A_p2049	COG0217	transcriptional regulatory protein
O23A_p2050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O23A_p2051	COG1801	Protein of unknown function DUF72
O23A_p2052	COG4106	trans-aconitate 2-methyltransferase activity
O23A_p2053	COG0500	methyltransferase
O23A_p2057	COG0450	alkyl hydroperoxide reductase
O23A_p2058	COG0583	DNA-binding transcription factor activity
O23A_p2061	COG0791	NLP P60 protein
O23A_p2064	COG1309	transcriptional regulator
O23A_p2072	COG0534	Mate efflux family protein
O23A_p2075	COG2841	Protein conserved in bacteria
O23A_p2076	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O23A_p2076	COG0674	pyruvate-flavodoxin oxidoreductase activity
O23A_p2076	COG1013	pyruvate-flavodoxin oxidoreductase activity
O23A_p2076	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O23A_p2078	COG3217	Mosc domain protein beta barrel domain protein
O23A_p2078	COG0633	Ferredoxin
O23A_p2078	COG3217	Mosc domain protein beta barrel domain protein
O23A_p2078	COG0633	Ferredoxin
O23A_p2080	COG0501	Belongs to the peptidase M48B family
O23A_p2081	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O23A_p2082	COG2226	methyltransferase
O23A_p2082	COG1073	alpha beta
O23A_p2083	COG0156	8-amino-7-oxononanoate synthase activity
O23A_p2084	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O23A_p2088	COG0017	Asparaginyl-tRNA synthetase
O23A_p2089	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O23A_p2093	COG0583	DNA-binding transcription factor activity
O23A_p2094	COG1393	Belongs to the ArsC family
O23A_p2095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O23A_p2096	COG1876	peptidase activity
O23A_p2098	COG3263	regulation of cellular component size
O23A_p2100	COG3263	regulation of cellular component size
O23A_p2102	COG1280	lysine exporter protein (LysE YggA)
O23A_p2103	COG0840	transmembrane signaling receptor activity
O23A_p2107	COG1957	nucleoside hydrolase
O23A_p2108	COG0564	pseudouridine synthase activity
O23A_p2110	COG1454	alcohol dehydrogenase
O23A_p2118	COG2894	cell division
O23A_p2120	COG4964	Belongs to the GSP D family
O23A_p2127	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_p2128	COG0702	epimerase
O23A_p2130	COG2867	negative regulation of translational initiation
O23A_p2132	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O23A_p2138	COG0210	DNA helicase
O23A_p2146	COG0745	RESPONSE REGULATOR receiver
O23A_p2146	COG3706	GGDEF domain
O23A_p2148	COG1595	DNA-templated transcription, initiation
O23A_p2150	COG3220	belongs to the UPF0276 family
O23A_p2153	COG5001	Diguanylate cyclase
O23A_p2153	COG3300	MHYT domain
O23A_p2154	COG2199	diguanylate cyclase activity
O23A_p2154	COG2203	Gaf domain
O23A_p2155	COG0589	response to stress
O23A_p2156	COG0659	secondary active sulfate transmembrane transporter activity
O23A_p2162	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_p2181	COG2003	Belongs to the UPF0758 family
O23A_p2193	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O23A_p2203	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O23A_p2209	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_p2212	COG0538	isocitrate dehydrogenase activity
O23A_p2213	COG2207	Transcriptional regulator
O23A_p2214	COG1482	cell wall glycoprotein biosynthetic process
O23A_p2216	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_p2217	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O23A_p2218	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_p2218	COG1263	PTS System
O23A_p2220	COG1609	Transcriptional regulator
O23A_p2225	COG2814	Major facilitator Superfamily
O23A_p2226	COG0109	protoheme IX farnesyltransferase activity
O23A_p2227	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O23A_p2228	COG1845	cytochrome c oxidase, subunit III
O23A_p2229	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O23A_p2230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O23A_p2242	COG0708	Exodeoxyribonuclease III
O23A_p2248	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p2249	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p2251	COG0095	Lipoate-protein ligase
O23A_p2257	COG0640	Transcriptional regulator
O23A_p2260	COG1285	pathogenesis
O23A_p2267	COG0484	heat shock protein binding
O23A_p2268	COG0443	Heat shock 70 kDa protein
O23A_p2269	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O23A_p2270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O23A_p2271	COG0497	DNA recombination
O23A_p2272	COG1227	inorganic diphosphatase activity
O23A_p2274	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p2275	COG1136	(ABC) transporter
O23A_p2275	COG0577	efflux transmembrane transporter activity
O23A_p2276	COG1538	Outer membrane efflux protein
O23A_p2277	COG2375	cellular response to nickel ion
O23A_p2278	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_p2279	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_p2284	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_p2285	COG1396	sequence-specific DNA binding
O23A_p2285	COG1917	Cupin 2, conserved barrel domain protein
O23A_p2288	COG0531	amino acid
O23A_p2290	COG0531	amino acid
O23A_p2291	COG1283	sodium-dependent phosphate transmembrane transporter activity
O23A_p2293	COG3384	dioxygenase
O23A_p2297	COG0813	purine-nucleoside phosphorylase activity
O23A_p2302	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O23A_p2303	COG0083	homoserine kinase activity
O23A_p2305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
O23A_p2307	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
O23A_p2311	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O23A_p2314	COG0745	RESPONSE REGULATOR receiver
O23A_p2315	COG4988	ABC transporter
O23A_p2316	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O23A_p2320	COG1720	tRNA m6t6A37 methyltransferase activity
O23A_p2324	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O23A_p2325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p2327	COG2190	(PTS) system
O23A_p2328	COG3706	GGDEF domain
O23A_p2330	COG3038	cytochrome b561
O23A_p2332	COG0419	ATPase involved in DNA repair
O23A_p2333	COG0420	3'-5' exonuclease activity
O23A_p2335	COG2974	May be involved in recombination
O23A_p2336	COG0405	Gamma-glutamyltransferase
O23A_p2338	COG4651	solute:proton antiporter activity
O23A_p2338	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O23A_p2341	COG0469	pyruvate kinase activity
O23A_p2342	COG3264	Mechanosensitive ion channel
O23A_p2342	COG1196	nuclear chromosome segregation
O23A_p2346	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p2351	COG0281	malic enzyme
O23A_p2354	COG0437	4 iron, 4 sulfur cluster binding
O23A_p2355	COG3383	formate dehydrogenase (NAD+) activity
O23A_p2355	COG3383	formate dehydrogenase (NAD+) activity
O23A_p2363	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O23A_p2365	COG3852	Histidine kinase
O23A_p2366	COG2204	response regulator
O23A_p2369	COG4662	Binding-protein-dependent transport system inner membrane component
O23A_p2371	COG0746	molybdenum cofactor guanylyltransferase activity
O23A_p2372	COG0303	'Molybdopterin
O23A_p2373	COG1289	transmembrane transporter activity
O23A_p2374	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O23A_p2379	COG0784	Response regulator, receiver
O23A_p2379	COG2205	protein histidine kinase activity
O23A_p2382	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_p2384	COG4608	Belongs to the ABC transporter superfamily
O23A_p2386	COG2971	BadF BadG BcrA BcrD
O23A_p2389	COG0840	transmembrane signaling receptor activity
O23A_p2392	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O23A_p2393	COG3724	N-succinylarginine dihydrolase activity
O23A_p2394	COG0616	signal peptide processing
O23A_p2395	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p2396	COG0583	DNA-binding transcription factor activity
O23A_p2399	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O23A_p2401	COG0583	DNA-binding transcription factor activity
O23A_p2403	COG1881	PFAM PEBP family protein
O23A_p2405	COG0366	Alpha amylase catalytic
O23A_p2413	COG2203	Gaf domain
O23A_p2413	COG2199	diguanylate cyclase activity
O23A_p2414	COG0037	tRNA processing
O23A_p2415	COG3590	peptidase
O23A_p2417	COG0488	(ABC) transporter
O23A_p2419	COG0531	amino acid
O23A_p2420	COG0814	amino acid
O23A_p2423	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O23A_p2424	COG1982	Orn Lys Arg decarboxylase major
O23A_p2425	COG0531	amino acid
O23A_p2426	COG3710	Transcriptional regulator
O23A_p2427	COG0825	malonyl-CoA metabolic process
O23A_p2429	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O23A_p2430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_p2431	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_p2432	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O23A_p2433	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_p2436	COG0750	zinc metalloprotease
O23A_p2438	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O23A_p2439	COG0575	Belongs to the CDS family
O23A_p2440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O23A_p2441	COG0233	cytoplasmic translational termination
O23A_p2442	COG0528	UMP kinase activity
O23A_p2443	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O23A_p2444	COG0052	Belongs to the universal ribosomal protein uS2 family
O23A_p2446	COG0024	Methionine aminopeptidase
O23A_p2447	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O23A_p2448	COG2171	N-acyltransferase activity
O23A_p2450	COG1263	PTS System
O23A_p2450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_p2452	COG4580	involved in the transport of maltose and maltodextrins
O23A_p2454	COG0564	pseudouridine synthase activity
O23A_p2455	COG3098	single-species biofilm formation
O23A_p2460	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
O23A_p2463	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O23A_p2463	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O23A_p2466	COG3706	GGDEF domain
O23A_p2467	COG1611	Belongs to the LOG family
O23A_p2468	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O23A_p2469	COG0473	3-isopropylmalate dehydrogenase activity
O23A_p2471	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
O23A_p2472	COG2363	Small membrane protein
O23A_p2474	COG0583	DNA-binding transcription factor activity
O23A_p2475	COG0840	transmembrane signaling receptor activity
O23A_p2476	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_p2479	COG1477	protein flavinylation
O23A_p2480	COG2871	sodium ion transport
O23A_p2481	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_p2482	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_p2483	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_p2484	COG1805	sodium ion transport
O23A_p2485	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_p2486	COG0271	Belongs to the BolA IbaG family
O23A_p2487	COG2813	Specifically methylates the guanine in position
O23A_p2489	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O23A_p2491	COG2211	Major facilitator Superfamily
O23A_p2492	COG3248	Nucleoside-binding outer membrane protein
O23A_p2493	COG1666	GTP binding
O23A_p2494	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O23A_p2499	COG3459	Glycosyltransferase 36 associated
O23A_p2505	COG3501	Rhs element vgr protein
O23A_p2508	COG2771	luxR family
O23A_p2509	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_p2509	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O23A_p2510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O23A_p2512	COG1151	hydroxylamine reductase activity
O23A_p2513	COG0783	Belongs to the Dps family
O23A_p2518	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O23A_p2522	COG0300	oxidoreductase activity
O23A_p2524	COG0415	Belongs to the DNA photolyase family
O23A_p2525	COG0789	Transcriptional regulator
O23A_p2526	COG3272	Protein of unknown function (DUF1722)
O23A_p2533	COG1605	Chorismate mutase
O23A_p2533	COG0077	Prephenate dehydratase
O23A_p2537	COG2133	pyrroloquinoline quinone binding
O23A_p2539	COG1349	DNA-binding transcription factor activity
O23A_p2540	COG2084	Dehydrogenase
O23A_p2542	COG0235	Class ii aldolase
O23A_p2543	COG3622	Belongs to the hyi family
O23A_p2544	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_p2545	COG2610	gluconate transmembrane transporter activity
O23A_p2547	COG0840	transmembrane signaling receptor activity
O23A_p2547	COG5278	phosphoserine phosphatase activity
O23A_p2550	COG0300	oxidoreductase activity
O23A_p2555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O23A_p2558	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O23A_p2560	COG3813	Protein conserved in bacteria
O23A_p2562	COG0826	peptidase U32
O23A_p2563	COG1280	lysine exporter protein (LysE YggA)
O23A_p2566	COG0840	transmembrane signaling receptor activity
O23A_p2569	COG2198	Histidine kinase
O23A_p2569	COG0643	Histidine kinase
O23A_p2571	COG0835	chemotaxis
O23A_p2572	COG0840	transmembrane signaling receptor activity
O23A_p2574	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O23A_p2575	COG2201	protein-glutamate methylesterase activity
O23A_p2576	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O23A_p2580	COG2197	response regulator
O23A_p2583	COG3188	usher protein
O23A_p2586	COG2200	EAL domain
O23A_p2586	COG2203	Gaf domain
O23A_p2586	COG2199	diguanylate cyclase activity
O23A_p2607	COG0659	secondary active sulfate transmembrane transporter activity
O23A_p2608	COG3039	Transposase
O23A_p2609	COG3039	Transposase
O23A_p2611	COG1309	transcriptional regulator
O23A_p2614	COG1136	(ABC) transporter
O23A_p2617	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O23A_p2629	COG1538	Outer membrane efflux protein
O23A_p2630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p2633	COG0745	RESPONSE REGULATOR receiver
O23A_p2634	COG5002	protein histidine kinase activity
O23A_p2635	COG2801	Transposase and inactivated derivatives
O23A_p2640	COG2132	Multicopper oxidase
O23A_p2642	COG3039	Transposase
O23A_p2644	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O23A_p2645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_p2648	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_p2649	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_p2650	COG0305	Participates in initiation and elongation during chromosome replication
O23A_p2656	COG0737	Belongs to the 5'-nucleotidase family
O23A_p2660	COG2204	response regulator
O23A_p2661	COG0545	Peptidyl-prolyl cis-trans isomerase
O23A_p2663	COG2900	Belongs to the SlyX family
O23A_p2664	COG1047	Peptidyl-prolyl cis-trans
O23A_p2665	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
O23A_p2667	COG0835	chemotaxis
O23A_p2667	COG0784	Response regulator, receiver
O23A_p2668	COG0429	hydrolase of the alpha beta-hydrolase fold
O23A_p2669	COG2203	Gaf domain
O23A_p2669	COG4251	negative regulation of phosphorylation
O23A_p2669	COG5001	Diguanylate cyclase
O23A_p2669	COG3706	GGDEF domain
O23A_p2670	COG3089	Belongs to the UPF0270 family
O23A_p2674	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_p2675	COG0463	Glycosyl transferase, family 2
O23A_p2676	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_p2676	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O23A_p2677	COG0726	polysaccharide deacetylase
O23A_p2678	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O23A_p2679	COG2076	Multidrug Resistance protein
O23A_p2680	COG2076	Multidrug Resistance protein
O23A_p2681	COG3954	Phosphoribulokinase
O23A_p2684	COG1765	OsmC-like protein
O23A_p2685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O23A_p2686	COG2226	methyltransferase
O23A_p2687	COG3397	chitin binding
O23A_p2690	COG2202	Pas domain
O23A_p2690	COG2205	protein histidine kinase activity
O23A_p2692	COG3655	Transcriptional regulator
O23A_p2694	COG2814	Major facilitator Superfamily
O23A_p2696	COG4771	TonB-dependent receptor
O23A_p2700	COG0748	coenzyme F420 binding
O23A_p2701	COG3721	Heme iron utilization protein
O23A_p2703	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_p2709	COG0741	lytic transglycosylase activity
O23A_p2710	COG0488	(ABC) transporter
O23A_p2712	COG2252	PERMEase
O23A_p2713	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O23A_p2714	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O23A_p2715	COG3178	'Phosphotransferase
O23A_p2716	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O23A_p2718	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O23A_p2719	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O23A_p2721	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O23A_p2724	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O23A_p2726	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O23A_p2728	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p2730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O23A_p2731	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O23A_p2732	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O23A_p2733	COG0142	geranyltranstransferase activity
O23A_p2734	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
O23A_p2735	COG0330	HflC and HflK could
O23A_p2736	COG0330	HflC and HflK could
O23A_p2737	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O23A_p2738	COG1923	regulation of RNA biosynthetic process
O23A_p2739	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O23A_p2740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O23A_p2743	COG0802	atpase or kinase
O23A_p2744	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O23A_p2744	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O23A_p2750	COG2011	ABC-type metal ion transport system permease component
O23A_p2751	COG1464	Belongs to the NlpA lipoprotein family
O23A_p2755	COG0840	transmembrane signaling receptor activity
O23A_p2760	COG5002	protein histidine kinase activity
O23A_p2760	COG2198	Histidine kinase
O23A_p2760	COG0784	Response regulator, receiver
O23A_p2767	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O23A_p2768	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O23A_p2770	COG2716	regulation of RNA biosynthetic process
O23A_p2771	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O23A_p2772	COG3013	Belongs to the UPF0304 family
O23A_p2773	COG3092	negative regulation of chromosome organization
O23A_p2774	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O23A_p2775	COG0857	belongs to the CobB CobQ family
O23A_p2775	COG0280	phosphate acetyltransferase
O23A_p2776	COG0440	acetolactate synthase activity
O23A_p2777	COG0028	Belongs to the TPP enzyme family
O23A_p2781	COG0671	phosphoesterase, PA-phosphatase related
O23A_p2783	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O23A_p2784	COG0473	3-isopropylmalate dehydrogenase activity
O23A_p2785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O23A_p2786	COG0066	3-isopropylmalate dehydratase activity
O23A_p2789	COG4143	(ABC) transporter
O23A_p2790	COG1178	ABC-type Fe3 transport system permease component
O23A_p2791	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
O23A_p2793	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O23A_p2795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_p2798	COG0316	Belongs to the HesB IscA family
O23A_p2800	COG0038	chloride channel
O23A_p2801	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O23A_p2806	COG0671	phosphoesterase, PA-phosphatase related
O23A_p2808	COG3437	response regulator, receiver
O23A_p2808	COG0784	Response regulator, receiver
O23A_p2809	COG0583	DNA-binding transcription factor activity
O23A_p2810	COG2076	Multidrug Resistance protein
O23A_p2812	COG0346	lactoylglutathione lyase activity
O23A_p2813	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O23A_p2814	COG1643	Atp-dependent helicase
O23A_p2816	COG1489	DNA binding
O23A_p2817	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O23A_p2818	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_p2819	COG0617	tRNA 3'-terminal CCA addition
O23A_p2820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O23A_p2821	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O23A_p2822	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O23A_p2824	COG0842	Transport permease protein
O23A_p2825	COG1131	(ABC) transporter
O23A_p2828	COG0163	prenyltransferase activity
O23A_p2829	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O23A_p2830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O23A_p2831	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O23A_p2832	COG2816	NAD+ diphosphatase activity
O23A_p2834	COG4991	sh3 domain protein
O23A_p2835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O23A_p2839	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O23A_p2840	COG1640	4-alpha-glucanotransferase
O23A_p2842	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_p2843	COG0676	glucose-6-phosphate 1-epimerase activity
O23A_p2844	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O23A_p2845	COG0840	transmembrane signaling receptor activity
O23A_p2846	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
O23A_p2847	COG2885	chlorophyll binding
O23A_p2848	COG0823	Involved in the tonB-independent uptake of proteins
O23A_p2851	COG0811	peptide transport
O23A_p2852	COG0824	Thioesterase
O23A_p2853	COG3790	cyd operon protein YbgE
O23A_p2854	COG4890	Cyd operon protein YbgT
O23A_p2855	COG1294	oxidase, subunit
O23A_p2856	COG1271	oxidase subunit
O23A_p2858	COG2255	four-way junction helicase activity
O23A_p2859	COG0632	four-way junction helicase activity
O23A_p2860	COG0840	transmembrane signaling receptor activity
O23A_p2861	COG0442	prolyl-tRNA aminoacylation
O23A_p2863	COG1902	pentaerythritol trinitrate reductase activity
O23A_p2865	COG0456	acetyltransferase
O23A_p2867	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O23A_p2868	COG3706	GGDEF domain
O23A_p2868	COG0745	RESPONSE REGULATOR receiver
O23A_p2869	COG5001	Diguanylate cyclase
O23A_p2869	COG3300	MHYT domain
O23A_p2872	COG0714	Associated with various cellular activities
O23A_p2875	COG0456	acetyltransferase
O23A_p2877	COG1022	Amp-dependent synthetase and ligase
O23A_p2879	COG2918	glutathione biosynthetic process
O23A_p2880	COG0612	Peptidase, M16
O23A_p2881	COG1238	metal cluster binding
O23A_p2882	COG1064	alcohol dehydrogenase
O23A_p2888	COG0359	binds to the 23S rRNA
O23A_p2889	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O23A_p2890	COG0360	Binds together with S18 to 16S ribosomal RNA
O23A_p2891	COG1914	H( )-stimulated, divalent metal cation uptake system
O23A_p2892	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O23A_p2895	COG2153	protein acetylation
O23A_p2897	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O23A_p2898	COG0557	exoribonuclease II activity
O23A_p2899	COG3706	GGDEF domain
O23A_p2900	COG1854	S-ribosylhomocysteine lyase activity
O23A_p2903	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_p2903	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O23A_p2911	COG4968	Prepilin-type N-terminal cleavage methylation domain
O23A_p2913	COG2207	Transcriptional regulator
O23A_p2916	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O23A_p2917	COG1047	Peptidyl-prolyl cis-trans
O23A_p2918	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O23A_p2919	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O23A_p2920	COG0196	riboflavin kinase activity
O23A_p2921	COG0728	peptidoglycan biosynthetic process
O23A_p2922	COG0268	Binds directly to 16S ribosomal RNA
O23A_p2923	COG0640	Transcriptional regulator
O23A_p2924	COG0583	DNA-binding transcription factor activity
O23A_p2926	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_p2927	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_p2936	COG0659	secondary active sulfate transmembrane transporter activity
O23A_p2937	COG0589	response to stress
O23A_p2943	COG1393	Belongs to the ArsC family
O23A_p2944	COG0798	PFAM Bile acid sodium symporter
O23A_p2946	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_p2948	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O23A_p2951	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O23A_p2952	COG0640	Transcriptional regulator
O23A_p2956	COG0437	4 iron, 4 sulfur cluster binding
O23A_p2957	COG0243	molybdopterin cofactor binding
O23A_p2958	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_p2962	COG4974	Belongs to the 'phage' integrase family
O23A_p2963	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_p2964	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O23A_p2966	COG1051	belongs to the nudix hydrolase family
O23A_p2969	COG3066	DNA modification
O23A_p2971	COG0335	large ribosomal subunit rRNA binding
O23A_p2972	COG0336	Belongs to the RNA methyltransferase TrmD family
O23A_p2973	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O23A_p2974	COG0228	four-way junction DNA binding
O23A_p2976	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O23A_p2977	COG4137	Cytochrome C assembly protein
O23A_p2978	COG4536	flavin adenine dinucleotide binding
O23A_p2979	COG1959	2 iron, 2 sulfur cluster binding
O23A_p2980	COG1017	nitric oxide dioxygenase activity
O23A_p2980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O23A_p2981	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O23A_p2982	COG0039	L-malate dehydrogenase activity
O23A_p2983	COG4160	amino acid transport
O23A_p2986	COG4215	(ABC) transporter
O23A_p2987	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p2988	COG1126	abc transporter atp-binding protein
O23A_p2989	COG1438	arginine binding
O23A_p2990	COG2837	iron assimilation
O23A_p2991	COG3842	ATPase activity
O23A_p2993	COG1840	ABC-type Fe3 transport system, periplasmic component
O23A_p2994	COG0347	Belongs to the P(II) protein family
O23A_p2997	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_p3001	COG1929	Belongs to the glycerate kinase type-1 family
O23A_p3002	COG2610	gluconate transmembrane transporter activity
O23A_p3003	COG3835	regulator
O23A_p3004	COG3112	Uncharacterised protein family (UPF0231)
O23A_p3007	COG0840	transmembrane signaling receptor activity
O23A_p3008	COG3568	Endonuclease Exonuclease Phosphatase
O23A_p3011	COG0513	Belongs to the DEAD box helicase family
O23A_p3019	COG1448	Aminotransferase
O23A_p3023	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O23A_p3024	COG1328	CTP reductase activity
O23A_p3028	COG4946	Tricorn protease homolog
O23A_p3028	COG0793	Belongs to the peptidase S41A family
O23A_p3031	COG1215	transferase activity, transferring glycosyl groups
O23A_p3032	COG0726	polysaccharide deacetylase
O23A_p3032	COG1649	PFAM Uncharacterised BCR, COG1649
O23A_p3041	COG3397	chitin binding
O23A_p3042	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p3043	COG1126	abc transporter atp-binding protein
O23A_p3045	COG0765	amino acid transport
O23A_p3046	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O23A_p3047	COG0583	DNA-binding transcription factor activity
O23A_p3048	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O23A_p3049	COG4208	sulfate ABC transporter
O23A_p3050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
O23A_p3052	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O23A_p3053	COG3174	membrane
O23A_p3054	COG0110	maltose O-acetyltransferase activity
O23A_p3060	COG1942	4-Oxalocrotonate Tautomerase
O23A_p3062	COG0583	DNA-binding transcription factor activity
O23A_p3063	COG0165	Argininosuccinate lyase
O23A_p3064	COG0137	argininosuccinate synthase activity
O23A_p3066	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O23A_p3067	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O23A_p3069	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O23A_p3071	COG2072	flavoprotein involved in K transport
O23A_p3072	COG1393	Belongs to the ArsC family
O23A_p3073	COG0798	PFAM Bile acid sodium symporter
O23A_p3076	COG0640	Transcriptional regulator
O23A_p3077	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O23A_p3081	COG3068	Protein conserved in bacteria
O23A_p3083	COG0739	heme binding
O23A_p3087	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O23A_p3088	COG1121	(ABC) transporter
O23A_p3089	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O23A_p3090	COG0583	DNA-binding transcription factor activity
O23A_p3092	COG1573	uracil-dna glycosylase
O23A_p3093	COG2962	Rard protein
O23A_p3095	COG2827	Endonuclease containing a URI domain
O23A_p3098	COG1842	Phage shock protein A
O23A_p3099	COG0204	Acyl-transferase
O23A_p3103	COG3118	belongs to the thioredoxin family
O23A_p3105	COG2259	Doxx family
O23A_p3115	COG0583	DNA-binding transcription factor activity
O23A_p3118	COG0187	DNA topoisomerase II activity
O23A_p3121	COG1051	belongs to the nudix hydrolase family
O23A_p3122	COG3150	esterase
O23A_p3124	COG3151	Protein conserved in bacteria
O23A_p3125	COG0494	nUDIX hydrolase
O23A_p3126	COG1538	Outer membrane efflux protein
O23A_p3128	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O23A_p3128	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
O23A_p3129	COG1560	Kdo2-lipid A biosynthetic process
O23A_p3133	COG1392	Phosphate transport regulator
O23A_p3134	COG0306	phosphate transporter
O23A_p3135	COG0617	tRNA 3'-terminal CCA addition
O23A_p3136	COG3267	Type II secretory pathway component ExeA
O23A_p3136	COG3409	Peptidoglycan-binding domain 1 protein
O23A_p3138	COG1194	a g-specific adenine glycosylase
O23A_p3139	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O23A_p3141	COG3111	PFAM Bacterial OB fold (BOF) protein
O23A_p3142	COG3240	lipase activity
O23A_p3145	COG3009	Protein conserved in bacteria
O23A_p3146	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O23A_p3146	COG3008	intermembrane lipid transfer
O23A_p3147	COG2995	paraquat-inducible protein a
O23A_p3150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_p3152	COG4251	negative regulation of phosphorylation
O23A_p3152	COG2203	Gaf domain
O23A_p3152	COG3706	GGDEF domain
O23A_p3152	COG5001	Diguanylate cyclase
O23A_p3153	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O23A_p3154	COG2813	Specifically methylates the guanine in position
O23A_p3155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O23A_p3156	COG0297	glycogen (starch) synthase activity
O23A_p3159	COG1757	Na H antiporter
O23A_p3161	COG0110	maltose O-acetyltransferase activity
O23A_p3162	COG0366	Alpha amylase catalytic
O23A_p3163	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_p3163	COG1263	PTS System
O23A_p3164	COG1609	Transcriptional regulator
O23A_p3166	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_p3167	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_p3168	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_p3168	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_p3169	COG2723	6-phospho-beta-galactosidase activity
O23A_p3170	COG1447	Phosphotransferase system cellobiose-specific component IIA
O23A_p3171	COG1940	carbohydrate kinase activity
O23A_p3174	COG1609	Transcriptional regulator
O23A_p3176	COG0252	asparaginase activity
O23A_p3179	COG1803	Methylglyoxal synthase
O23A_p3184	COG1444	tRNA N-acetyltransferase activity
O23A_p3185	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p3186	COG0784	Response regulator, receiver
O23A_p3186	COG0835	chemotaxis
O23A_p3192	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O23A_p3193	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O23A_p3196	COG0477	Major facilitator Superfamily
O23A_p3197	COG0523	cobalamin synthesis protein
O23A_p3199	COG1280	lysine exporter protein (LysE YggA)
O23A_p3202	COG0583	DNA-binding transcription factor activity
O23A_p3203	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p3204	COG2200	EAL domain
O23A_p3205	COG1049	propionate catabolic process, 2-methylcitrate cycle
O23A_p3207	COG0840	transmembrane signaling receptor activity
O23A_p3208	COG0840	transmembrane signaling receptor activity
O23A_p3210	COG5001	Diguanylate cyclase
O23A_p3210	COG3447	MASE1 domain protein
O23A_p3210	COG5002	protein histidine kinase activity
O23A_p3211	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O23A_p3212	COG0508	dehydrogenase complex catalyzes the overall conversion of
O23A_p3213	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O23A_p3214	COG2186	Transcriptional regulator
O23A_p3220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_p3221	COG1459	type II secretion system
O23A_p3222	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O23A_p3224	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
O23A_p3225	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O23A_p3226	COG0494	nUDIX hydrolase
O23A_p3228	COG0653	protein targeting
O23A_p3230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O23A_p3231	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O23A_p3232	COG0849	cell division
O23A_p3233	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O23A_p3234	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O23A_p3235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O23A_p3236	COG0772	Belongs to the SEDS family
O23A_p3237	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O23A_p3238	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O23A_p3239	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O23A_p3241	COG0768	penicillin binding
O23A_p3242	COG3116	cell division
O23A_p3243	COG0275	rRNA processing
O23A_p3244	COG2001	Belongs to the MraZ family
O23A_p3245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O23A_p3246	COG3107	peptidoglycan biosynthetic process
O23A_p3247	COG0792	nuclease activity
O23A_p3248	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O23A_p3249	COG2823	Periplasmic or secreted lipoprotein
O23A_p3250	COG2969	positive regulation of protein catabolic process
O23A_p3251	COG0625	glutathione transferase activity
O23A_p3252	COG2857	Cytochrome c1
O23A_p3253	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O23A_p3254	COG0723	plastoquinol--plastocyanin reductase activity
O23A_p3256	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O23A_p3257	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O23A_p3258	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O23A_p3260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O23A_p3261	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O23A_p3267	COG3964	amidohydrolase
O23A_p3271	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p3272	COG1660	Displays ATPase and GTPase activities
O23A_p3273	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p3275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O23A_p3276	COG1137	ATPase activity
O23A_p3277	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O23A_p3278	COG3117	lipopolysaccharide transmembrane transporter activity
O23A_p3279	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
O23A_p3280	COG0517	IMP dehydrogenase activity
O23A_p3280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O23A_p3281	COG1127	ABC transporter
O23A_p3282	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O23A_p3283	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O23A_p3284	COG2854	intermembrane phospholipid transfer
O23A_p3286	COG5007	Belongs to the BolA IbaG family
O23A_p3287	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O23A_p3288	COG0312	modulator of DNA gyrase
O23A_p3289	COG3028	Belongs to the UPF0307 family
O23A_p3291	COG2926	Belongs to the UPF0265 family
O23A_p3294	COG1396	sequence-specific DNA binding
O23A_p3295	COG3135	benzoate transporter
O23A_p3301	COG3047	cAMP biosynthetic process
O23A_p3303	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O23A_p3304	COG2197	response regulator
O23A_p3311	COG1278	Cold shock
O23A_p3312	COG4771	TonB-dependent receptor
O23A_p3313	COG3706	GGDEF domain
O23A_p3314	COG2205	protein histidine kinase activity
O23A_p3315	COG0745	RESPONSE REGULATOR receiver
O23A_p3322	COG0745	RESPONSE REGULATOR receiver
O23A_p3322	COG3706	GGDEF domain
O23A_p3323	COG0347	Belongs to the P(II) protein family
O23A_p3324	COG0004	ammonium transporteR
O23A_p3328	COG0346	lactoylglutathione lyase activity
O23A_p3333	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O23A_p3334	COG1074	ATP-dependent DNA helicase activity
O23A_p3335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O23A_p3336	COG2259	Doxx family
O23A_p3337	COG1741	Belongs to the pirin family
O23A_p3339	COG0583	DNA-binding transcription factor activity
O23A_p3345	COG1176	ABC-type spermidine putrescine transport system, permease component I
O23A_p3347	COG3842	ATPase activity
O23A_p3349	COG2203	Gaf domain
O23A_p3349	COG2199	diguanylate cyclase activity
O23A_p3353	COG1247	-acetyltransferase
O23A_p3354	COG0753	catalase activity
O23A_p3359	COG0494	nUDIX hydrolase
O23A_p3360	COG0628	permease
O23A_p3361	COG3284	Transcriptional regulator
O23A_p3363	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
O23A_p3363	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p3363	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O23A_p3364	COG1461	Dihydroxyacetone kinase
O23A_p3365	COG2376	Dihydroxyacetone kinase
O23A_p3366	COG2252	PERMEase
O23A_p3369	COG0203	ribosomal protein L17
O23A_p3370	COG0202	RNA polymerase activity
O23A_p3371	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O23A_p3372	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O23A_p3373	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O23A_p3374	COG0201	protein transport
O23A_p3375	COG0200	Binds to the 23S rRNA
O23A_p3376	COG1841	ribosomal large subunit assembly
O23A_p3377	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O23A_p3378	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O23A_p3379	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O23A_p3380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O23A_p3381	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O23A_p3382	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O23A_p3383	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O23A_p3384	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O23A_p3385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O23A_p3386	COG0255	Belongs to the universal ribosomal protein uL29 family
O23A_p3387	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O23A_p3388	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O23A_p3389	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O23A_p3390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O23A_p3391	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O23A_p3392	COG0089	rRNA binding
O23A_p3393	COG0088	Forms part of the polypeptide exit tunnel
O23A_p3394	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O23A_p3395	COG0051	transcription antitermination factor activity, RNA binding
O23A_p3398	COG0745	RESPONSE REGULATOR receiver
O23A_p3399	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O23A_p3400	COG2183	response to ionizing radiation
O23A_p3404	COG0596	Alpha beta hydrolase
O23A_p3405	COG1040	competence protein
O23A_p3406	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O23A_p3406	COG0316	Belongs to the HesB IscA family
O23A_p3407	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O23A_p3408	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O23A_p3409	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_p3410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O23A_p3411	COG4942	peptidase
O23A_p3413	COG1609	Transcriptional regulator
O23A_p3414	COG0800	Aldolase
O23A_p3415	COG0129	dihydroxy-acid dehydratase activity
O23A_p3416	COG3265	gluconokinase activity
O23A_p3417	COG2610	gluconate transmembrane transporter activity
O23A_p3418	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_p3420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O23A_p3422	COG0456	acetyltransferase
O23A_p3426	COG4106	trans-aconitate 2-methyltransferase activity
O23A_p3427	COG1490	D-aminoacyl-tRNA deacylase activity
O23A_p3428	COG1295	ribonuclease BN
O23A_p3430	COG0174	glutamine synthetase
O23A_p3432	COG3852	Histidine kinase
O23A_p3433	COG2204	response regulator
O23A_p3434	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O23A_p3435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O23A_p3437	COG3078	GTPase activator activity
O23A_p3440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O23A_p3441	COG3039	Transposase
O23A_p3443	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O23A_p3444	COG0408	coproporphyrinogen oxidase activity
O23A_p3445	COG0009	L-threonylcarbamoyladenylate synthase
O23A_p3447	COG0551	DNA topoisomerase type I activity
O23A_p3448	COG2922	Belongs to the Smg family
O23A_p3449	COG0758	DNA mediated transformation
O23A_p3451	COG1652	LysM domain
O23A_p3452	COG0242	peptide deformylase activity
O23A_p3453	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O23A_p3454	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_p3454	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_p3455	COG0569	domain protein
O23A_p3456	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_p3457	COG1322	Protein conserved in bacteria
O23A_p3461	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_p3462	COG0686	Belongs to the AlaDH PNT family
O23A_p3463	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O23A_p3463	COG0519	Catalyzes the synthesis of GMP from XMP
O23A_p3467	COG1012	belongs to the aldehyde dehydrogenase family
O23A_p3469	COG2962	Rard protein
O23A_p3471	COG1280	lysine exporter protein (LysE YggA)
O23A_p3473	COG2391	methyltransferase activity
O23A_p3476	COG1280	lysine exporter protein (LysE YggA)
O23A_p3481	COG2823	Periplasmic or secreted lipoprotein
O23A_p3489	COG1943	Transposase
O23A_p3491	COG0210	DNA helicase
O23A_p3496	COG0583	DNA-binding transcription factor activity
O23A_p3500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O23A_p3501	COG0385	Bile acid
O23A_p3502	COG1609	Transcriptional regulator
O23A_p3503	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O23A_p3506	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O23A_p3507	COG3074	FtsZ-dependent cytokinesis
O23A_p3509	COG1045	serine acetyltransferase
O23A_p3511	COG0745	RESPONSE REGULATOR receiver
O23A_p3512	COG2205	protein histidine kinase activity
O23A_p3513	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O23A_p3514	COG0534	Mate efflux family protein
O23A_p3517	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O23A_p3518	COG2937	Belongs to the GPAT DAPAT family
O23A_p3519	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O23A_p3520	COG3161	chorismate lyase activity
O23A_p3521	COG1580	Controls the rotational direction of flagella during chemotaxis
O23A_p3525	COG0604	alcohol dehydrogenase
O23A_p3526	COG1609	Transcriptional regulator
O23A_p3527	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p3530	COG1519	Transferase
O23A_p3531	COG0859	PFAM glycosyl transferase family 9
O23A_p3533	COG0463	Glycosyl transferase, family 2
O23A_p3534	COG0859	PFAM glycosyl transferase family 9
O23A_p3535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O23A_p3536	COG2990	Protein conserved in bacteria
O23A_p3537	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O23A_p3539	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O23A_p3540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O23A_p3541	COG2003	Belongs to the UPF0758 family
O23A_p3542	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O23A_p3543	COG0756	dUTP diphosphatase activity
O23A_p3544	COG1309	transcriptional regulator
O23A_p3545	COG0668	transmembrane transport
O23A_p3547	COG0166	Belongs to the GPI family
O23A_p3548	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O23A_p3549	COG0583	DNA-binding transcription factor activity
O23A_p3552	COG0045	succinate-CoA ligase (ADP-forming) activity
O23A_p3552	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p3552	COG1042	CoA-binding domain protein
O23A_p3555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O23A_p3556	COG4206	TonB-dependent receptor
O23A_p3557	COG0583	DNA-binding transcription factor activity
O23A_p3560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O23A_p3561	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O23A_p3562	COG2223	nitrite transmembrane transporter activity
O23A_p3563	COG3279	Response regulator of the LytR AlgR family
O23A_p3564	COG3275	phosphorelay sensor kinase activity
O23A_p3565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p3565	COG2205	protein histidine kinase activity
O23A_p3567	COG2197	response regulator
O23A_p3568	COG2205	protein histidine kinase activity
O23A_p3568	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p3573	COG3539	Fimbrial protein
O23A_p3576	COG3121	Chaperone
O23A_p3577	COG3188	usher protein
O23A_p3583	COG2081	HI0933 family
O23A_p3584	COG1528	Iron-storage protein
O23A_p3585	COG3706	GGDEF domain
O23A_p3586	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O23A_p3587	COG0589	response to stress
O23A_p3595	COG3642	lipopolysaccharide core region biosynthetic process
O23A_p3596	COG0859	PFAM glycosyl transferase family 9
O23A_p3598	COG0194	GDP metabolic process
O23A_p3599	COG1758	RNA polymerase activity
O23A_p3600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O23A_p3601	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O23A_p3602	COG2267	carboxylic ester hydrolase activity
O23A_p3603	COG0561	phosphatase activity
O23A_p3606	COG1309	transcriptional regulator
O23A_p3607	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p3608	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_p3609	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p3609	COG4191	Histidine kinase
O23A_p3610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O23A_p3616	COG2205	protein histidine kinase activity
O23A_p3617	COG0745	RESPONSE REGULATOR receiver
O23A_p3618	COG2814	Major facilitator Superfamily
O23A_p3620	COG3977	Valine--pyruvate aminotransferase
O23A_p3621	COG0071	Belongs to the small heat shock protein (HSP20) family
O23A_p3622	COG0071	Belongs to the small heat shock protein (HSP20) family
O23A_p3623	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O23A_p3625	COG2378	regulation of single-species biofilm formation
O23A_p3628	COG0187	DNA topoisomerase II activity
O23A_p3630	COG0592	DNA-directed DNA polymerase activity
O23A_p3631	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O23A_p3636	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O23A_p3637	COG0594	ribonuclease P activity
O23A_p3638	COG0706	membrane insertase activity
O23A_p3639	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O23A_p3642	COG3433	isochorismatase activity
O23A_p3642	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_p3642	COG2226	methyltransferase
O23A_p3644	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_p3648	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_p3649	COG4605	iron ion homeostasis
O23A_p3650	COG4604	ABC transporter, ATP-binding protein
O23A_p3651	COG4607	ABC-type enterochelin transport system periplasmic component
O23A_p3652	COG4774	siderophore transport
O23A_p3654	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O23A_p3656	COG1120	ATPase activity
O23A_p3657	COG4615	Cyclic peptide transporter
O23A_p3658	COG4774	siderophore transport
O23A_p3659	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O23A_p3660	COG0445	tRNA wobble uridine modification
O23A_p3661	COG0357	Ribosomal RNA small subunit methyltransferase G
O23A_p3662	COG1192	Involved in chromosome partitioning
O23A_p3663	COG1475	DNA binding
O23A_p3664	COG3312	ion transport
O23A_p3665	COG0356	it plays a direct role in the translocation of protons across the membrane
O23A_p3667	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O23A_p3668	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O23A_p3669	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O23A_p3670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O23A_p3671	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O23A_p3672	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O23A_p3673	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O23A_p3674	COG4452	Inner membrane protein CreD
O23A_p3676	COG2205	protein histidine kinase activity
O23A_p3677	COG0745	RESPONSE REGULATOR receiver
O23A_p3678	COG1349	DNA-binding transcription factor activity
O23A_p3679	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O23A_p3680	COG2771	luxR family
O23A_p3682	COG0811	peptide transport
O23A_p3683	COG0811	peptide transport
O23A_p3684	COG0848	biopolymer transport protein
O23A_p3685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O23A_p3688	COG0402	S-adenosylhomocysteine deaminase activity
O23A_p3689	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O23A_p3691	COG3165	ubiquinone biosynthetic process from chorismate
O23A_p3692	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O23A_p3694	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O23A_p3695	COG0805	protein transport
O23A_p3696	COG0084	hydrolase, TatD family'
O23A_p3700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_p3701	COG0742	ribosomal rna small subunit methyltransferase
O23A_p3703	COG0248	Ppx GppA phosphatase
O23A_p3704	COG0513	Belongs to the DEAD box helicase family
O23A_p3705	COG3118	belongs to the thioredoxin family
O23A_p3706	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O23A_p3708	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O23A_p3713	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_p3719	COG0559	Belongs to the binding-protein-dependent transport system permease family
O23A_p3721	COG1609	Transcriptional regulator
O23A_p3724	COG2188	Transcriptional regulator
O23A_p3725	COG3604	Transcriptional regulator
O23A_p3726	COG0426	domain, Protein
O23A_p3726	COG1773	rubredoxin
O23A_p3727	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_p3730	COG0348	domain, Protein
O23A_p3731	COG0814	amino acid
O23A_p3734	COG0640	Transcriptional regulator
O23A_p3737	COG2202	Pas domain
O23A_p3737	COG2199	diguanylate cyclase activity
O23A_p3737	COG2200	EAL domain
O23A_p3739	COG0529	Catalyzes the synthesis of activated sulfate
O23A_p3741	COG0751	glycine-tRNA ligase activity
O23A_p3742	COG0752	glycyl-tRNA synthetase alpha subunit
O23A_p3743	COG2818	Glycosylase
O23A_p3744	COG2885	chlorophyll binding
O23A_p3745	COG0251	oxidation-reduction process
O23A_p3746	COG0425	Belongs to the sulfur carrier protein TusA family
O23A_p3750	COG2205	protein histidine kinase activity
O23A_p3751	COG0745	RESPONSE REGULATOR receiver
O23A_p3752	COG0183	Belongs to the thiolase family
O23A_p3753	COG1024	Enoyl-CoA hydratase
O23A_p3753	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_p3754	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O23A_p3755	COG0006	proline dipeptidase activity
O23A_p3756	COG1739	Uncharacterized protein family UPF0029
O23A_p3757	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_p3758	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
O23A_p3760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O23A_p3761	COG2166	iron-sulfur cluster assembly
O23A_p3762	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O23A_p3764	COG0210	DNA helicase
O23A_p3767	COG1063	alcohol dehydrogenase
O23A_p3770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_p3771	COG0438	transferase activity, transferring glycosyl groups
O23A_p3775	COG0859	PFAM glycosyl transferase family 9
O23A_p3777	COG1561	YicC-like family, N-terminal region
O23A_p3779	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O23A_p3782	COG4251	negative regulation of phosphorylation
O23A_p3782	COG2203	Gaf domain
O23A_p3782	COG3706	GGDEF domain
O23A_p3782	COG5001	Diguanylate cyclase
O23A_p3783	COG3084	Protein conserved in bacteria
O23A_p3785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O23A_p3786	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O23A_p3787	COG3639	organic phosphonate transmembrane transporter activity
O23A_p3788	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
O23A_p3789	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
O23A_p3792	COG1335	isochorismatase
O23A_p3795	COG0204	Acyl-transferase
O23A_p3796	COG0606	chelatase, subunit chli
O23A_p3797	COG1404	Belongs to the peptidase S8 family
O23A_p3798	COG0464	growth
O23A_p3809	COG0210	DNA helicase
O23A_p3811	COG0606	chelatase, subunit chli
O23A_p3813	COG3978	acetolactate synthase activity
O23A_p3814	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O23A_p3815	COG0129	dihydroxy-acid dehydratase activity
O23A_p3819	COG1309	transcriptional regulator
O23A_p3821	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O23A_p3822	COG0254	rRNA binding
O23A_p3823	COG0702	epimerase
O23A_p3824	COG0281	malic enzyme
O23A_p3826	COG2205	protein histidine kinase activity
O23A_p3829	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_p3835	COG4310	Domain of unknown function (DUF2172)
O23A_p3839	COG2089	acid synthase
O23A_p3841	COG1083	cytidylyl-transferase
O23A_p3845	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p3849	COG1215	transferase activity, transferring glycosyl groups
O23A_p3852	COG1216	Glycosyl transferase, family 2
O23A_p3858	COG0529	Catalyzes the synthesis of activated sulfate
O23A_p3861	COG0574	Belongs to the PEP-utilizing enzyme family
O23A_p3861	COG3848	Pyruvate phosphate dikinase
O23A_p3862	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O23A_p3863	COG1213	nucleotidyl transferase
O23A_p3864	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_p3865	COG1086	Polysaccharide biosynthesis protein
O23A_p3866	COG0366	Alpha amylase catalytic
O23A_p3869	COG0443	Heat shock 70 kDa protein
O23A_p3870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O23A_p3871	COG3045	CreA protein
O23A_p3873	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O23A_p3874	COG0174	glutamine synthetase
O23A_p3878	COG3842	ATPase activity
O23A_p3879	COG1176	ABC-type spermidine putrescine transport system, permease component I
O23A_p3880	COG1177	transmembrane transport
O23A_p3881	COG2258	MOSC domain
O23A_p3884	COG2050	protein possibly involved in aromatic compounds catabolism
O23A_p3885	COG0514	ATP-dependent DNA helicase (RecQ)
O23A_p3887	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O23A_p3889	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O23A_p3891	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O23A_p3893	COG2239	Acts as a magnesium transporter
O23A_p3894	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O23A_p3894	COG1648	precorrin-2 dehydrogenase activity
O23A_p3895	COG2116	formate transmembrane transporter activity
O23A_p3896	COG2146	nitrite reductase [NAD(P)H] activity
O23A_p3898	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_p3900	COG0477	Major facilitator Superfamily
O23A_p3901	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O23A_p3902	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O23A_p3904	COG0018	arginyl-trna synthetase
O23A_p3906	COG1595	DNA-templated transcription, initiation
O23A_p3908	COG1968	undecaprenyl-diphosphatase activity
O23A_p3909	COG0667	Aldo Keto reductase
O23A_p3910	COG2017	converts alpha-aldose to the beta-anomer
O23A_p3912	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O23A_p3914	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O23A_p3915	COG1609	Transcriptional regulator
O23A_p3916	COG3250	beta-galactosidase activity
O23A_p3920	COG4211	Belongs to the binding-protein-dependent transport system permease family
O23A_p3929	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O23A_p3930	COG1288	antiporter activity
O23A_p3932	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
O23A_p3933	COG0540	Belongs to the ATCase OTCase family
O23A_p3936	COG0688	phosphatidylethanolamine metabolic process
O23A_p3939	COG3040	lipid binding
O23A_p3940	COG2207	Transcriptional regulator
O23A_p3941	COG1979	alcohol dehydrogenase
O23A_p3942	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O23A_p3943	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O23A_p3945	COG2964	Protein conserved in bacteria
O23A_p3946	COG3681	Belongs to the UPF0597 family
O23A_p3948	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_p3949	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_p3950	COG0564	pseudouridine synthase activity
O23A_p3952	COG0542	response to heat
O23A_p3953	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O23A_p3954	COG2502	aspartate--ammonia ligase
O23A_p3955	COG1522	sequence-specific DNA binding
O23A_p3957	COG5413	integral membrane protein
O23A_p3958	COG0516	GMP reductase activity
O23A_p3958	COG0517	IMP dehydrogenase activity
O23A_p3959	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p3962	COG2205	protein histidine kinase activity
O23A_p3964	COG2204	response regulator
O23A_p3967	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O23A_p3968	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
O23A_p3971	COG0745	RESPONSE REGULATOR receiver
O23A_p3972	COG2205	protein histidine kinase activity
O23A_p3974	COG0243	molybdopterin cofactor binding
O23A_p3975	COG3005	denitrification pathway
O23A_p3976	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O23A_p3977	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_p3978	COG0569	domain protein
O23A_p3979	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O23A_p3982	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O23A_p3983	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O23A_p3984	COG0250	Participates in transcription elongation, termination and antitermination
O23A_p3985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O23A_p3986	COG0081	regulation of translation
O23A_p3987	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O23A_p3988	COG0222	ribosome binding
O23A_p3989	COG0085	RNA polymerase activity
O23A_p3990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O23A_p3991	COG2964	Protein conserved in bacteria
O23A_p3994	COG2923	Belongs to the DsrF TusC family
O23A_p3995	COG2168	tRNA wobble position uridine thiolation
O23A_p3996	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O23A_p3997	COG0049	tRNA binding
O23A_p3998	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O23A_p3999	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O23A_p4000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O23A_p4005	COG2249	NAD(P)H dehydrogenase (quinone) activity
O23A_p4008	COG1770	oligopeptidase
O23A_p4012	COG3714	YhhN family
O23A_p4017	COG1301	dicarboxylic acid transport
O23A_p4019	COG2095	MarC family integral membrane protein
O23A_p4021	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O23A_p4024	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_p4026	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_p4032	COG0742	ribosomal rna small subunit methyltransferase
O23A_p4033	COG0552	protein localization to endoplasmic reticulum
O23A_p4034	COG2884	Cell division ATP-binding protein ftsE
O23A_p4035	COG2177	Part of the ABC transporter FtsEX involved in
O23A_p4038	COG0288	reversible hydration of carbon dioxide
O23A_p4039	COG2188	Transcriptional regulator
O23A_p4040	COG1228	amidohydrolase
O23A_p4041	COG0010	Belongs to the arginase family
O23A_p4042	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O23A_p4043	COG2986	histidine ammonia-lyase
O23A_p4044	COG0387	Pfam Sodium calcium exchanger
O23A_p4047	COG2199	diguanylate cyclase activity
O23A_p4047	COG2200	EAL domain
O23A_p4056	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_p4057	COG1459	type II secretion system
O23A_p4061	COG4968	Prepilin-type N-terminal cleavage methylation domain
O23A_p4066	COG1077	Cell shape determining protein MreB Mrl
O23A_p4067	COG1792	Involved in formation and maintenance of cell shape
O23A_p4068	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O23A_p4069	COG0424	maF-like protein
O23A_p4070	COG1530	ribonuclease E activity
O23A_p4071	COG3164	Protein of unknown function
O23A_p4073	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_p4074	COG0312	modulator of DNA gyrase
O23A_p4077	COG0477	Major facilitator Superfamily
O23A_p4079	COG3437	response regulator, receiver
O23A_p4080	COG2205	protein histidine kinase activity
O23A_p4080	COG5002	protein histidine kinase activity
O23A_p4080	COG0784	Response regulator, receiver
O23A_p4081	COG2172	sigma factor antagonist activity
O23A_p4082	COG1366	Belongs to the anti-sigma-factor antagonist family
O23A_p4084	COG3700	Belongs to the class B bacterial acid phosphatase family
O23A_p4087	COG1639	'signal transduction protein
O23A_p4092	COG0189	ligase activity
O23A_p4094	COG0745	RESPONSE REGULATOR receiver
O23A_p4098	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O23A_p4099	COG0352	thiamine-phosphate diphosphorylase activity
O23A_p4100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O23A_p4102	COG2022	thiamine diphosphate biosynthetic process
O23A_p4103	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O23A_p4105	COG2131	deaminase
O23A_p4107	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p4108	COG0110	maltose O-acetyltransferase activity
O23A_p4109	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
O23A_p4113	COG0814	amino acid
O23A_p4114	COG3932	Exopolysaccharide synthesis, ExoD
O23A_p4117	COG1733	regulation of RNA biosynthetic process
O23A_p4125	COG1494	fructose-1,6-bisphosphatase
O23A_p4128	COG2959	enzyme of heme biosynthesis
O23A_p4130	COG0181	hydroxymethylbilane synthase activity
O23A_p4131	COG3072	Adenylate cyclase
O23A_p4132	COG0400	carboxylic ester hydrolase activity
O23A_p4133	COG1965	Belongs to the frataxin family
O23A_p4135	COG0019	diaminopimelate decarboxylase activity
O23A_p4136	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O23A_p4139	COG1011	Hydrolase
O23A_p4141	COG0668	transmembrane transport
O23A_p4143	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O23A_p4144	COG0561	phosphatase activity
O23A_p4147	COG0842	Transport permease protein
O23A_p4147	COG1129	ABC transporter
O23A_p4149	COG1546	Belongs to the CinA family
O23A_p4149	COG1058	Belongs to the CinA family
O23A_p4150	COG1418	mRNA catabolic process
O23A_p4151	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O23A_p4153	COG1522	sequence-specific DNA binding
O23A_p4154	COG1368	sulfuric ester hydrolase activity
O23A_p4159	COG1285	pathogenesis
O23A_p4163	COG4221	oxidoreductase activity
O23A_p4167	COG1979	alcohol dehydrogenase
O23A_p4169	COG2873	o-acetylhomoserine
O23A_p4172	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O23A_p4175	COG5380	lipid catabolic process
O23A_p4176	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O23A_p4179	COG2949	membrane
O23A_p4180	COG3291	Pkd domain containing protein
O23A_p4183	COG3539	Fimbrial protein
O23A_p4185	COG3188	usher protein
O23A_p4186	COG3121	Chaperone
O23A_p4187	COG3539	Fimbrial protein
O23A_p4190	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_p4192	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O23A_p4193	COG0596	Alpha beta hydrolase
O23A_p4194	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O23A_p4195	COG1169	isochorismate synthase
O23A_p4196	COG1575	Belongs to the MenA family. Type 1 subfamily
O23A_p4202	COG0513	Belongs to the DEAD box helicase family
O23A_p4204	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_p4205	COG1988	membrane-bound metal-dependent
O23A_p4208	COG1671	Belongs to the UPF0178 family
O23A_p4212	COG0484	heat shock protein binding
O23A_p4213	COG3263	regulation of cellular component size
O23A_p4214	COG3722	fumarate hydratase activity
O23A_p4215	COG0246	Mannitol dehydrogenase
O23A_p4216	COG2213	PTS system mannitol-specific
O23A_p4216	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_p4220	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
O23A_p4224	COG2771	luxR family
O23A_p4227	COG3133	Outer membrane lipoprotein
O23A_p4228	COG0456	acetyltransferase
O23A_p4232	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O23A_p4233	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O23A_p4237	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_p4238	COG1459	type II secretion system
O23A_p4239	COG2165	general secretion pathway protein
O23A_p4241	COG2165	general secretion pathway protein
O23A_p4242	COG4795	General secretion pathway protein
O23A_p4243	COG4795	General secretion pathway protein
O23A_p4244	COG4795	General secretion pathway protein
O23A_p4245	COG3156	type II secretion system protein K
O23A_p4247	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O23A_p4250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O23A_p4251	COG1011	Hydrolase
O23A_p4252	COG0494	nUDIX hydrolase
O23A_p4253	COG1218	3'(2'),5'-bisphosphate nucleotidase
O23A_p4254	COG0814	amino acid
O23A_p4255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_p4258	COG0626	cystathionine gamma-synthase activity
O23A_p4259	COG0527	aspartate kinase activity
O23A_p4259	COG0460	homoserine dehydrogenase
O23A_p4262	COG1346	cytolysis
O23A_p4263	COG1380	Effector of murein hydrolase LrgA
O23A_p4264	COG0583	DNA-binding transcription factor activity
O23A_p4271	COG1546	Belongs to the CinA family
O23A_p4272	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O23A_p4274	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O23A_p4275	COG0527	aspartate kinase activity
O23A_p4276	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O23A_p4278	COG1686	Belongs to the peptidase S11 family
O23A_p4279	COG0586	Pfam SNARE associated Golgi protein
O23A_p4280	COG1253	flavin adenine dinucleotide binding
O23A_p4282	COG2927	DNA polymerase III (CHI subunit)
O23A_p4283	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_p4285	COG0795	lipopolysaccharide-transporting ATPase activity
O23A_p4286	COG0795	lipopolysaccharide-transporting ATPase activity
O23A_p4288	COG0004	ammonium transporteR
O23A_p4289	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_p4293	COG0084	hydrolase, TatD family'
O23A_p4294	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_p4296	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O23A_p4297	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O23A_p4298	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O23A_p4299	COG0813	purine-nucleoside phosphorylase activity
O23A_p4302	COG0560	Phosphoserine phosphatase
O23A_p4307	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
O23A_p4309	COG0776	regulation of translation
O23A_p4312	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O23A_p4318	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O23A_p4319	COG0513	Belongs to the DEAD box helicase family
O23A_p4320	COG3022	response to hydroperoxide
O23A_p4323	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O23A_p4324	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O23A_p4325	COG0762	integral membrane protein
O23A_p4326	COG1872	DUF167
O23A_p4329	COG4166	transmembrane transport
O23A_p4331	COG0110	maltose O-acetyltransferase activity
O23A_p4333	COG1024	Enoyl-CoA hydratase
O23A_p4336	COG4221	oxidoreductase activity
O23A_p4338	COG2957	Belongs to the agmatine deiminase family
O23A_p4339	COG0154	amidase activity
O23A_p4344	COG0513	Belongs to the DEAD box helicase family
O23A_p4348	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
O23A_p4358	COG2205	protein histidine kinase activity
O23A_p4359	COG0745	RESPONSE REGULATOR receiver
O23A_p4360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p4361	COG0577	efflux transmembrane transporter activity
O23A_p4361	COG1136	(ABC) transporter
O23A_p4363	COG1505	serine-type exopeptidase activity
O23A_p4365	COG2982	Protein involved in outer membrane biogenesis
O23A_p4367	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p4368	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O23A_p4370	COG3730	PTS system glucitol sorbitol-specific
O23A_p4374	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_p4376	COG1349	DNA-binding transcription factor activity
O23A_p4377	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O23A_p4381	COG2130	NADP-dependent
O23A_p4382	COG1764	response to oxidative stress
O23A_p4383	COG1846	Transcriptional regulator
O23A_p4390	COG0561	phosphatase activity
O23A_p4393	COG0733	neurotransmitter:sodium symporter activity
O23A_p4395	COG0733	neurotransmitter:sodium symporter activity
O23A_p4400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_p4403	COG1794	racemase activity, acting on amino acids and derivatives
O23A_p4405	COG2731	YhcH YjgK YiaL family protein
O23A_p4407	COG0668	transmembrane transport
O23A_p4408	COG1376	ErfK ybiS ycfS ynhG family protein
O23A_p4409	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O23A_p4411	COG0789	Transcriptional regulator
O23A_p4418	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O23A_p4420	COG0488	(ABC) transporter
O23A_p4421	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O23A_p4421	COG0517	IMP dehydrogenase activity
O23A_p4422	COG1585	Membrane protein implicated in regulation of membrane protease activity
O23A_p4423	COG0330	HflC and HflK could
O23A_p4424	COG1648	precorrin-2 dehydrogenase activity
O23A_p4424	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O23A_p4425	COG0175	sulfate reduction
O23A_p4426	COG2895	sulfate adenylyltransferase (ATP) activity
O23A_p4427	COG3273	potassium ion transport
O23A_p4427	COG0471	metal ion transport
O23A_p4429	COG0529	Catalyzes the synthesis of activated sulfate
O23A_p4432	COG0840	transmembrane signaling receptor activity
O23A_p4439	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O23A_p4443	COG1940	carbohydrate kinase activity
O23A_p4444	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_p4445	COG0126	phosphoglycerate kinase activity
O23A_p4446	COG0191	fructose-bisphosphate aldolase activity
O23A_p4447	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_p4454	COG0583	DNA-binding transcription factor activity
O23A_p4458	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O23A_p4459	COG1595	DNA-templated transcription, initiation
O23A_p4460	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
O23A_p4463	COG0481	GTPase activity
O23A_p4464	COG0681	Belongs to the peptidase S26 family
O23A_p4465	COG0571	ribonuclease III activity
O23A_p4467	COG1381	Involved in DNA repair and RecF pathway recombination
O23A_p4468	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O23A_p4469	COG3023	N-Acetylmuramoyl-L-alanine amidase
O23A_p4470	COG4807	Protein conserved in bacteria
O23A_p4472	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_p4473	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O23A_p4474	COG3956	TIGRFAM MazG family protein
O23A_p4475	COG0504	CTP synthase activity
O23A_p4476	COG0148	phosphopyruvate hydratase activity
O23A_p4477	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O23A_p4478	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O23A_p4480	COG0585	pseudouridine synthase activity
O23A_p4481	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O23A_p4482	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O23A_p4483	COG1238	metal cluster binding
O23A_p4484	COG1388	LysM domain
O23A_p4484	COG4942	peptidase
O23A_p4486	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O23A_p4487	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O23A_p4488	COG1610	YqeY-like protein
O23A_p4489	COG0358	DNA primase activity
O23A_p4490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O23A_p4495	COG0151	Belongs to the GarS family
O23A_p4496	COG0138	bifunctional purine biosynthesis protein purh
O23A_p4499	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O23A_p4500	COG3036	rescue of stalled ribosome
O23A_p4501	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O23A_p4502	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O23A_p4504	COG0673	inositol 2-dehydrogenase activity
O23A_p4506	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p4507	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p4508	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_p4509	COG3227	Zinc metalloprotease (Elastase)
O23A_p4511	COG0477	Major facilitator Superfamily
O23A_p4513	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O23A_p4514	COG1027	Aspartate ammonia-lyase
O23A_p4515	COG3030	protein affecting phage T7 exclusion by the F plasmid
O23A_p4517	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O23A_p4518	COG0459	protein refolding
O23A_p4520	COG5001	Diguanylate cyclase
O23A_p4520	COG3300	MHYT domain
O23A_p4522	COG0564	pseudouridine synthase activity
O23A_p4523	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O23A_p4525	COG1280	lysine exporter protein (LysE YggA)
O23A_p4526	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O23A_p4530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_p4536	COG0745	RESPONSE REGULATOR receiver
O23A_p4537	COG3104	oligopeptide transport
O23A_p4538	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O23A_p4539	COG1555	photosystem II stabilization
O23A_p4541	COG2350	Protein conserved in bacteria
O23A_p4542	COG2917	probably involved in intracellular septation
O23A_p4543	COG0076	glutamate decarboxylase activity
O23A_p4544	COG1272	protein, Hemolysin III
O23A_p4545	COG0569	domain protein
O23A_p4545	COG2985	domain, Protein