locus-tag	class	description
CE456_00050	COG3039	Transposase
CE456_00225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE456_00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_00275	COG1357	PFAM Pentapeptide repeats (8 copies)
CE456_00315	COG3316	Transposase and inactivated derivatives
CE456_00385	COG4372	Transposase
CE456_00400	COG3316	Transposase and inactivated derivatives
CE456_00415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE456_00435	COG4644	lycopene metabolic process
CE456_00440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE456_00485	COG3173	Aminoglycoside phosphotransferase
CE456_00535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE456_00555	COG3316	Transposase and inactivated derivatives
CE456_00590	COG3316	Transposase and inactivated derivatives
CE456_00735	COG2200	EAL domain
CE456_00735	COG2771	luxR family
CE456_00845	COG0592	DNA-directed DNA polymerase activity
CE456_00860	COG4372	Transposase
CE456_01145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE456_01165	COG1192	Involved in chromosome partitioning
CE456_01220	COG2003	Belongs to the UPF0758 family
CE456_01275	COG3039	Transposase
CE456_01425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE456_01430	COG2361	Protein of unknown function DUF86
CE456_01450	COG1192	Involved in chromosome partitioning
CE456_01465	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE456_01570	COG1484	DNA-dependent DNA replication
CE456_01590	COG1192	Involved in chromosome partitioning
CE456_01625	COG4792	protein secretion
CE456_01635	COG4794	Type iii secretion
CE456_01640	COG4790	Type iii secretion
CE456_01645	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE456_01710	COG0457	Tetratricopeptide repeat
CE456_01800	COG1317	bacterial-type flagellum organization
CE456_01805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE456_01835	COG3328	transposase activity
CE456_01845	COG1192	Involved in chromosome partitioning
CE456_01855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE456_01860	COG2361	Protein of unknown function DUF86
CE456_01915	COG1192	Involved in chromosome partitioning
CE456_01970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CE456_01975	COG0592	DNA-directed DNA polymerase activity
CE456_01985	COG0187	DNA topoisomerase II activity
CE456_02000	COG2378	regulation of single-species biofilm formation
CE456_02005	COG0071	Belongs to the small heat shock protein (HSP20) family
CE456_02010	COG0071	Belongs to the small heat shock protein (HSP20) family
CE456_02025	COG3977	Valine--pyruvate aminotransferase
CE456_02040	COG2814	Major facilitator Superfamily
CE456_02045	COG0745	RESPONSE REGULATOR receiver
CE456_02050	COG2205	protein histidine kinase activity
CE456_02075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE456_02080	COG4191	Histidine kinase
CE456_02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_02085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE456_02090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_02095	COG1309	transcriptional regulator
CE456_02125	COG0561	phosphatase activity
CE456_02130	COG2267	carboxylic ester hydrolase activity
CE456_02135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE456_02140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE456_02145	COG1758	RNA polymerase activity
CE456_02150	COG0194	GDP metabolic process
CE456_02160	COG0859	PFAM glycosyl transferase family 9
CE456_02165	COG3642	lipopolysaccharide core region biosynthetic process
CE456_02205	COG0589	response to stress
CE456_02210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE456_02220	COG1528	Iron-storage protein
CE456_02225	COG2081	HI0933 family
CE456_02250	COG5433	transposase activity
CE456_02275	COG5433	transposase activity
CE456_02290	COG2205	protein histidine kinase activity
CE456_02290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_02300	COG3275	phosphorelay sensor kinase activity
CE456_02305	COG3279	Response regulator of the LytR AlgR family
CE456_02310	COG2223	nitrite transmembrane transporter activity
CE456_02315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CE456_02320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CE456_02335	COG0583	DNA-binding transcription factor activity
CE456_02340	COG4206	TonB-dependent receptor
CE456_02345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CE456_02390	COG0583	DNA-binding transcription factor activity
CE456_02395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CE456_02400	COG0166	Belongs to the GPI family
CE456_02410	COG0668	transmembrane transport
CE456_02415	COG1309	transcriptional regulator
CE456_02420	COG0756	dUTP diphosphatase activity
CE456_02425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CE456_02430	COG2003	Belongs to the UPF0758 family
CE456_02435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CE456_02440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CE456_02450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CE456_02455	COG2990	Protein conserved in bacteria
CE456_02460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CE456_02465	COG0859	PFAM glycosyl transferase family 9
CE456_02470	COG0463	Glycosyl transferase, family 2
CE456_02475	COG0859	PFAM glycosyl transferase family 9
CE456_02480	COG1519	Transferase
CE456_02495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_02500	COG1609	Transcriptional regulator
CE456_02530	COG1580	Controls the rotational direction of flagella during chemotaxis
CE456_02535	COG3161	chorismate lyase activity
CE456_02540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CE456_02545	COG2937	Belongs to the GPAT DAPAT family
CE456_02550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CE456_02565	COG0534	Mate efflux family protein
CE456_02570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CE456_02575	COG2205	protein histidine kinase activity
CE456_02580	COG0745	RESPONSE REGULATOR receiver
CE456_02590	COG1045	serine acetyltransferase
CE456_02600	COG3074	FtsZ-dependent cytokinesis
CE456_02605	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CE456_02620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CE456_02670	COG1609	Transcriptional regulator
CE456_02675	COG0385	Bile acid
CE456_02700	COG0583	DNA-binding transcription factor activity
CE456_02725	COG0210	DNA helicase
CE456_02765	COG2391	methyltransferase activity
CE456_02770	COG5433	transposase activity
CE456_02780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE456_02795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CE456_02800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CE456_02810	COG0018	arginyl-trna synthetase
CE456_02820	COG1595	DNA-templated transcription, initiation
CE456_02830	COG1968	undecaprenyl-diphosphatase activity
CE456_02835	COG0667	Aldo Keto reductase
CE456_02840	COG2017	converts alpha-aldose to the beta-anomer
CE456_02845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE456_02855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE456_02860	COG1609	Transcriptional regulator
CE456_02865	COG3250	beta-galactosidase activity
CE456_02880	COG4211	Belongs to the binding-protein-dependent transport system permease family
CE456_02890	COG3328	transposase activity
CE456_02920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CE456_02925	COG1288	antiporter activity
CE456_02935	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CE456_02940	COG0540	Belongs to the ATCase OTCase family
CE456_02955	COG0688	phosphatidylethanolamine metabolic process
CE456_02965	COG3040	lipid binding
CE456_02975	COG1979	alcohol dehydrogenase
CE456_02980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CE456_02985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CE456_02995	COG2964	Protein conserved in bacteria
CE456_03000	COG3681	Belongs to the UPF0597 family
CE456_03010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE456_03015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE456_03020	COG0564	pseudouridine synthase activity
CE456_03030	COG0542	response to heat
CE456_03035	COG2502	aspartate--ammonia ligase
CE456_03040	COG1522	sequence-specific DNA binding
CE456_03050	COG5413	integral membrane protein
CE456_03055	COG0517	IMP dehydrogenase activity
CE456_03055	COG0516	GMP reductase activity
CE456_03060	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_03070	COG2205	protein histidine kinase activity
CE456_03080	COG2204	response regulator
CE456_03095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CE456_03100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CE456_03115	COG0745	RESPONSE REGULATOR receiver
CE456_03120	COG2205	protein histidine kinase activity
CE456_03130	COG0243	molybdopterin cofactor binding
CE456_03135	COG3005	denitrification pathway
CE456_03140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE456_03145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE456_03150	COG0569	domain protein
CE456_03155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CE456_03180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE456_03190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CE456_03195	COG0250	Participates in transcription elongation, termination and antitermination
CE456_03200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CE456_03205	COG0081	regulation of translation
CE456_03210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CE456_03215	COG0222	ribosome binding
CE456_03220	COG0085	RNA polymerase activity
CE456_03225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CE456_03230	COG2964	Protein conserved in bacteria
CE456_03245	COG2923	Belongs to the DsrF TusC family
CE456_03250	COG2168	tRNA wobble position uridine thiolation
CE456_03255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CE456_03260	COG0049	tRNA binding
CE456_03265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CE456_03270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE456_03275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE456_03335	COG3047	cAMP biosynthetic process
CE456_03365	COG3135	benzoate transporter
CE456_03370	COG1396	sequence-specific DNA binding
CE456_03410	COG2252	PERMEase
CE456_03415	COG2376	Dihydroxyacetone kinase
CE456_03420	COG1461	Dihydroxyacetone kinase
CE456_03425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_03425	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CE456_03425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE456_03435	COG3284	Transcriptional regulator
CE456_03440	COG0628	permease
CE456_03445	COG0494	nUDIX hydrolase
CE456_03470	COG0753	catalase activity
CE456_03475	COG1247	-acetyltransferase
CE456_03495	COG2199	diguanylate cyclase activity
CE456_03495	COG2203	Gaf domain
CE456_03505	COG3842	ATPase activity
CE456_03515	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE456_03540	COG0583	DNA-binding transcription factor activity
CE456_03550	COG1741	Belongs to the pirin family
CE456_03555	COG2259	Doxx family
CE456_03560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CE456_03565	COG1074	ATP-dependent DNA helicase activity
CE456_03570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CE456_03590	COG0346	lactoylglutathione lyase activity
CE456_03600	COG5433	transposase activity
CE456_03620	COG0347	Belongs to the P(II) protein family
CE456_03625	COG3706	GGDEF domain
CE456_03625	COG0745	RESPONSE REGULATOR receiver
CE456_03640	COG2205	protein histidine kinase activity
CE456_03645	COG3706	GGDEF domain
CE456_03655	COG1278	Cold shock
CE456_03665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CE456_03670	COG2197	response regulator
CE456_03720	COG2204	response regulator
CE456_03725	COG1677	Flagellar hook-basal body complex protein FliE
CE456_03735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE456_03760	COG2747	anti-sigma28 factor FlgM
CE456_03770	COG1815	bacterial-type flagellum-dependent cell motility
CE456_03775	COG1558	bacterial-type flagellum-dependent cell motility
CE456_03780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CE456_03785	COG1749	Flagellar hook protein flgE
CE456_03790	COG4786	Flagellar basal body rod
CE456_03795	COG4786	Flagellar basal body rod
CE456_03800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE456_03805	COG1706	bacterial-type flagellum-dependent cell motility
CE456_03815	COG4786	Flagellar basal body rod
CE456_03815	COG1256	bacterial-type flagellum assembly
CE456_03835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE456_03845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE456_03850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CE456_03875	COG1191	sigma factor activity
CE456_03880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE456_03885	COG1360	Flagellar Motor Protein
CE456_03895	COG1388	LysM domain
CE456_03895	COG0741	lytic transglycosylase activity
CE456_03905	COG2001	Belongs to the MraZ family
CE456_03910	COG0275	rRNA processing
CE456_03915	COG3116	cell division
CE456_03920	COG0768	penicillin binding
CE456_03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CE456_03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE456_03940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CE456_03945	COG0772	Belongs to the SEDS family
CE456_03950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CE456_03955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE456_03960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CE456_03965	COG0849	cell division
CE456_03970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CE456_03975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CE456_03985	COG0653	protein targeting
CE456_03995	COG0494	nUDIX hydrolase
CE456_04000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CE456_04005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CE456_04015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CE456_04025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE456_04060	COG2186	Transcriptional regulator
CE456_04065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CE456_04070	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE456_04075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE456_04080	COG5001	Diguanylate cyclase
CE456_04080	COG5002	protein histidine kinase activity
CE456_04080	COG3447	MASE1 domain protein
CE456_04090	COG0840	transmembrane signaling receptor activity
CE456_04095	COG0840	transmembrane signaling receptor activity
CE456_04105	COG1049	propionate catabolic process, 2-methylcitrate cycle
CE456_04110	COG2200	EAL domain
CE456_04115	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_04120	COG0583	DNA-binding transcription factor activity
CE456_04130	COG1280	lysine exporter protein (LysE YggA)
CE456_04140	COG0523	cobalamin synthesis protein
CE456_04160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CE456_04165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CE456_04305	COG0784	Response regulator, receiver
CE456_04305	COG0835	chemotaxis
CE456_04310	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_04315	COG1444	tRNA N-acetyltransferase activity
CE456_04340	COG1803	Methylglyoxal synthase
CE456_04355	COG0252	asparaginase activity
CE456_04365	COG1609	Transcriptional regulator
CE456_04375	COG1940	carbohydrate kinase activity
CE456_04380	COG1447	Phosphotransferase system cellobiose-specific component IIA
CE456_04385	COG2723	6-phospho-beta-galactosidase activity
CE456_04390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE456_04390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE456_04395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE456_04400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE456_04415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE456_04415	COG1263	PTS System
CE456_04420	COG0366	Alpha amylase catalytic
CE456_04425	COG0110	maltose O-acetyltransferase activity
CE456_04435	COG1757	Na H antiporter
CE456_04470	COG0297	glycogen (starch) synthase activity
CE456_04475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CE456_04480	COG2813	Specifically methylates the guanine in position
CE456_04485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE456_04500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE456_04510	COG2995	paraquat-inducible protein a
CE456_04515	COG3008	intermembrane lipid transfer
CE456_04515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE456_04520	COG3009	Protein conserved in bacteria
CE456_04535	COG3240	lipase activity
CE456_04540	COG3111	PFAM Bacterial OB fold (BOF) protein
CE456_04550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CE456_04555	COG1194	a g-specific adenine glycosylase
CE456_04565	COG3409	Peptidoglycan-binding domain 1 protein
CE456_04565	COG3267	Type II secretory pathway component ExeA
CE456_04570	COG0617	tRNA 3'-terminal CCA addition
CE456_04575	COG0306	phosphate transporter
CE456_04580	COG1392	Phosphate transport regulator
CE456_04595	COG1560	Kdo2-lipid A biosynthetic process
CE456_04600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CE456_04600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CE456_04605	COG1538	Outer membrane efflux protein
CE456_04610	COG0494	nUDIX hydrolase
CE456_04615	COG3151	Protein conserved in bacteria
CE456_04625	COG3150	esterase
CE456_04630	COG1051	belongs to the nudix hydrolase family
CE456_04640	COG0187	DNA topoisomerase II activity
CE456_04710	COG2259	Doxx family
CE456_04715	COG3118	belongs to the thioredoxin family
CE456_04735	COG0204	Acyl-transferase
CE456_04755	COG2827	Endonuclease containing a URI domain
CE456_04770	COG1573	uracil-dna glycosylase
CE456_04780	COG0583	DNA-binding transcription factor activity
CE456_04785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CE456_04790	COG1121	(ABC) transporter
CE456_04795	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CE456_04815	COG0739	heme binding
CE456_04825	COG3068	Protein conserved in bacteria
CE456_04845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE456_04865	COG0798	PFAM Bile acid sodium symporter
CE456_04870	COG1393	Belongs to the ArsC family
CE456_04880	COG2072	flavoprotein involved in K transport
CE456_04890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CE456_04900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CE456_04905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE456_04915	COG0137	argininosuccinate synthase activity
CE456_04920	COG0165	Argininosuccinate lyase
CE456_04925	COG0583	DNA-binding transcription factor activity
CE456_04935	COG1942	4-Oxalocrotonate Tautomerase
CE456_04965	COG0110	maltose O-acetyltransferase activity
CE456_04970	COG3174	membrane
CE456_04975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CE456_04985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CE456_04995	COG4208	sulfate ABC transporter
CE456_05000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CE456_05005	COG0583	DNA-binding transcription factor activity
CE456_05010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE456_05015	COG0765	amino acid transport
CE456_05025	COG1126	abc transporter atp-binding protein
CE456_05030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_05035	COG3397	chitin binding
CE456_05040	COG0840	transmembrane signaling receptor activity
CE456_05075	COG0726	polysaccharide deacetylase
CE456_05075	COG1649	PFAM Uncharacterised BCR, COG1649
CE456_05080	COG1215	transferase activity, transferring glycosyl groups
CE456_05125	COG1328	CTP reductase activity
CE456_05130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE456_05150	COG1448	Aminotransferase
CE456_05190	COG0513	Belongs to the DEAD box helicase family
CE456_05205	COG3568	Endonuclease Exonuclease Phosphatase
CE456_05210	COG0840	transmembrane signaling receptor activity
CE456_05225	COG3112	Uncharacterised protein family (UPF0231)
CE456_05230	COG3835	regulator
CE456_05235	COG2610	gluconate transmembrane transporter activity
CE456_05240	COG1929	Belongs to the glycerate kinase type-1 family
CE456_05260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE456_05275	COG0347	Belongs to the P(II) protein family
CE456_05280	COG1840	ABC-type Fe3 transport system, periplasmic component
CE456_05290	COG3842	ATPase activity
CE456_05295	COG2837	iron assimilation
CE456_05300	COG1438	arginine binding
CE456_05305	COG1126	abc transporter atp-binding protein
CE456_05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_05315	COG4215	(ABC) transporter
CE456_05320	COG4160	amino acid transport
CE456_05325	COG0039	L-malate dehydrogenase activity
CE456_05330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CE456_05335	COG1017	nitric oxide dioxygenase activity
CE456_05335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE456_05340	COG1959	2 iron, 2 sulfur cluster binding
CE456_05345	COG4536	flavin adenine dinucleotide binding
CE456_05350	COG4137	Cytochrome C assembly protein
CE456_05355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CE456_05360	COG0228	four-way junction DNA binding
CE456_05365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CE456_05370	COG0336	Belongs to the RNA methyltransferase TrmD family
CE456_05375	COG0335	large ribosomal subunit rRNA binding
CE456_05385	COG3066	DNA modification
CE456_05390	COG1051	belongs to the nudix hydrolase family
CE456_05400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CE456_05405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CE456_05410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE456_05420	COG0583	DNA-binding transcription factor activity
CE456_05425	COG0640	Transcriptional regulator
CE456_05430	COG0268	Binds directly to 16S ribosomal RNA
CE456_05435	COG0728	peptidoglycan biosynthetic process
CE456_05440	COG0196	riboflavin kinase activity
CE456_05445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CE456_05450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CE456_05455	COG1047	Peptidyl-prolyl cis-trans
CE456_05460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CE456_05465	COG4968	Prepilin-type N-terminal cleavage methylation domain
CE456_05500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CE456_05500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE456_05515	COG1854	S-ribosylhomocysteine lyase activity
CE456_05520	COG3706	GGDEF domain
CE456_05525	COG0557	exoribonuclease II activity
CE456_05530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE456_05540	COG2153	protein acetylation
CE456_05560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE456_05565	COG1914	H( )-stimulated, divalent metal cation uptake system
CE456_05570	COG0360	Binds together with S18 to 16S ribosomal RNA
CE456_05575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CE456_05580	COG0359	binds to the 23S rRNA
CE456_05610	COG1064	alcohol dehydrogenase
CE456_05615	COG1238	metal cluster binding
CE456_05620	COG0612	Peptidase, M16
CE456_05625	COG2918	glutathione biosynthetic process
CE456_05635	COG1022	Amp-dependent synthetase and ligase
CE456_05645	COG0456	acetyltransferase
CE456_05655	COG0714	Associated with various cellular activities
CE456_05680	COG3706	GGDEF domain
CE456_05680	COG0745	RESPONSE REGULATOR receiver
CE456_05685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CE456_05695	COG1902	pentaerythritol trinitrate reductase activity
CE456_05705	COG0442	prolyl-tRNA aminoacylation
CE456_05715	COG0632	four-way junction helicase activity
CE456_05720	COG2255	four-way junction helicase activity
CE456_05725	COG1271	oxidase subunit
CE456_05730	COG1294	oxidase, subunit
CE456_05735	COG4890	Cyd operon protein YbgT
CE456_05740	COG3790	cyd operon protein YbgE
CE456_05745	COG0824	Thioesterase
CE456_05750	COG0811	peptide transport
CE456_05765	COG0823	Involved in the tonB-independent uptake of proteins
CE456_05770	COG2885	chlorophyll binding
CE456_05775	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CE456_05840	COG0840	transmembrane signaling receptor activity
CE456_05845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CE456_05850	COG0676	glucose-6-phosphate 1-epimerase activity
CE456_05855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE456_05860	COG1640	4-alpha-glucanotransferase
CE456_05865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CE456_05885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE456_05890	COG4991	sh3 domain protein
CE456_05895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE456_05895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE456_05895	COG0506	proline dehydrogenase activity
CE456_05905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CE456_05910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CE456_05915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE456_05920	COG0163	prenyltransferase activity
CE456_05935	COG1131	(ABC) transporter
CE456_05940	COG0842	Transport permease protein
CE456_05950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CE456_05955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CE456_05960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CE456_05965	COG0617	tRNA 3'-terminal CCA addition
CE456_05970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE456_05975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE456_05980	COG1489	DNA binding
CE456_05990	COG1643	Atp-dependent helicase
CE456_05995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE456_06000	COG0346	lactoylglutathione lyase activity
CE456_06010	COG2076	Multidrug Resistance protein
CE456_06015	COG0583	DNA-binding transcription factor activity
CE456_06020	COG0784	Response regulator, receiver
CE456_06020	COG3437	response regulator, receiver
CE456_06030	COG0671	phosphoesterase, PA-phosphatase related
CE456_06045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CE456_06050	COG0038	chloride channel
CE456_06060	COG0316	Belongs to the HesB IscA family
CE456_06090	COG2816	NAD+ diphosphatase activity
CE456_06095	COG2205	protein histidine kinase activity
CE456_06100	COG0745	RESPONSE REGULATOR receiver
CE456_06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_06120	COG1505	serine-type exopeptidase activity
CE456_06125	COG2982	Protein involved in outer membrane biogenesis
CE456_06135	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_06170	COG1349	DNA-binding transcription factor activity
CE456_06175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CE456_06195	COG2130	NADP-dependent
CE456_06200	COG1764	response to oxidative stress
CE456_06205	COG1846	Transcriptional regulator
CE456_06235	COG0561	phosphatase activity
CE456_06250	COG0733	neurotransmitter:sodium symporter activity
CE456_06260	COG0733	neurotransmitter:sodium symporter activity
CE456_06285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE456_06300	COG1794	racemase activity, acting on amino acids and derivatives
CE456_06310	COG2731	YhcH YjgK YiaL family protein
CE456_06320	COG0668	transmembrane transport
CE456_06325	COG1376	ErfK ybiS ycfS ynhG family protein
CE456_06330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE456_06365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CE456_06375	COG0488	(ABC) transporter
CE456_06380	COG0517	IMP dehydrogenase activity
CE456_06380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE456_06385	COG1585	Membrane protein implicated in regulation of membrane protease activity
CE456_06390	COG0330	HflC and HflK could
CE456_06395	COG1648	precorrin-2 dehydrogenase activity
CE456_06395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE456_06400	COG0175	sulfate reduction
CE456_06405	COG2895	sulfate adenylyltransferase (ATP) activity
CE456_06410	COG0471	metal ion transport
CE456_06410	COG3273	potassium ion transport
CE456_06415	COG0529	Catalyzes the synthesis of activated sulfate
CE456_06420	COG5433	transposase activity
CE456_06485	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CE456_06510	COG1940	carbohydrate kinase activity
CE456_06515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE456_06520	COG0126	phosphoglycerate kinase activity
CE456_06525	COG0191	fructose-bisphosphate aldolase activity
CE456_06530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE456_06580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CE456_06585	COG1595	DNA-templated transcription, initiation
CE456_06590	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CE456_06605	COG0481	GTPase activity
CE456_06610	COG0681	Belongs to the peptidase S26 family
CE456_06615	COG0571	ribonuclease III activity
CE456_06625	COG1381	Involved in DNA repair and RecF pathway recombination
CE456_06630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CE456_06635	COG3023	N-Acetylmuramoyl-L-alanine amidase
CE456_06640	COG4807	Protein conserved in bacteria
CE456_06650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE456_06655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE456_06660	COG3956	TIGRFAM MazG family protein
CE456_06665	COG0504	CTP synthase activity
CE456_06670	COG0148	phosphopyruvate hydratase activity
CE456_06675	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CE456_06680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CE456_06690	COG0585	pseudouridine synthase activity
CE456_06695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CE456_06700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE456_06705	COG1238	metal cluster binding
CE456_06710	COG4942	peptidase
CE456_06710	COG1388	LysM domain
CE456_06720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CE456_06725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE456_06730	COG1610	YqeY-like protein
CE456_06735	COG0358	DNA primase activity
CE456_06740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CE456_06780	COG0151	Belongs to the GarS family
CE456_06785	COG0138	bifunctional purine biosynthesis protein purh
CE456_06795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CE456_06800	COG3036	rescue of stalled ribosome
CE456_06805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE456_06810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CE456_06820	COG0673	inositol 2-dehydrogenase activity
CE456_06830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE456_06835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE456_06840	COG3227	Zinc metalloprotease (Elastase)
CE456_06850	COG0477	Major facilitator Superfamily
CE456_06860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CE456_06865	COG1027	Aspartate ammonia-lyase
CE456_06870	COG3030	protein affecting phage T7 exclusion by the F plasmid
CE456_06880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CE456_06885	COG0459	protein refolding
CE456_06895	COG5001	Diguanylate cyclase
CE456_06895	COG3300	MHYT domain
CE456_06905	COG0564	pseudouridine synthase activity
CE456_06910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE456_06940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE456_06950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CE456_06955	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CE456_06960	COG1178	ABC-type Fe3 transport system permease component
CE456_06965	COG4143	(ABC) transporter
CE456_06980	COG0066	3-isopropylmalate dehydratase activity
CE456_06985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CE456_06990	COG0473	3-isopropylmalate dehydrogenase activity
CE456_06995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE456_07005	COG0671	phosphoesterase, PA-phosphatase related
CE456_07020	COG0028	Belongs to the TPP enzyme family
CE456_07025	COG0440	acetolactate synthase activity
CE456_07030	COG0280	phosphate acetyltransferase
CE456_07030	COG0857	belongs to the CobB CobQ family
CE456_07035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CE456_07040	COG3092	negative regulation of chromosome organization
CE456_07045	COG3013	Belongs to the UPF0304 family
CE456_07050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CE456_07055	COG2716	regulation of RNA biosynthetic process
CE456_07065	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CE456_07070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CE456_07105	COG0784	Response regulator, receiver
CE456_07105	COG2198	Histidine kinase
CE456_07105	COG5002	protein histidine kinase activity
CE456_07130	COG0840	transmembrane signaling receptor activity
CE456_07140	COG1464	Belongs to the NlpA lipoprotein family
CE456_07145	COG2011	ABC-type metal ion transport system permease component
CE456_07150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CE456_07170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CE456_07170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CE456_07175	COG0802	atpase or kinase
CE456_07185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CE456_07190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CE456_07195	COG1923	regulation of RNA biosynthetic process
CE456_07200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CE456_07205	COG0330	HflC and HflK could
CE456_07210	COG0330	HflC and HflK could
CE456_07215	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CE456_07220	COG0142	geranyltranstransferase activity
CE456_07225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CE456_07230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CE456_07235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CE456_07245	COG0318	PFAM AMP-dependent synthetase and ligase
CE456_07265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE456_07280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CE456_07290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CE456_07295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CE456_07305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CE456_07310	COG3178	'Phosphotransferase
CE456_07315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CE456_07320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE456_07325	COG2252	PERMEase
CE456_07335	COG0488	(ABC) transporter
CE456_07360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE456_07370	COG3721	Heme iron utilization protein
CE456_07375	COG0748	coenzyme F420 binding
CE456_07395	COG4771	TonB-dependent receptor
CE456_07400	COG2814	Major facilitator Superfamily
CE456_07410	COG3655	Transcriptional regulator
CE456_07445	COG3397	chitin binding
CE456_07455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE456_07460	COG1765	OsmC-like protein
CE456_07475	COG3954	Phosphoribulokinase
CE456_07485	COG2076	Multidrug Resistance protein
CE456_07490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CE456_07495	COG0726	polysaccharide deacetylase
CE456_07505	COG0463	Glycosyl transferase, family 2
CE456_07510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE456_07520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE456_07530	COG3089	Belongs to the UPF0270 family
CE456_07535	COG4251	negative regulation of phosphorylation
CE456_07535	COG2203	Gaf domain
CE456_07535	COG5001	Diguanylate cyclase
CE456_07535	COG3706	GGDEF domain
CE456_07540	COG0429	hydrolase of the alpha beta-hydrolase fold
CE456_07545	COG0835	chemotaxis
CE456_07545	COG0784	Response regulator, receiver
CE456_07555	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CE456_07560	COG1047	Peptidyl-prolyl cis-trans
CE456_07565	COG2900	Belongs to the SlyX family
CE456_07575	COG0545	Peptidyl-prolyl cis-trans isomerase
CE456_07580	COG2204	response regulator
CE456_07600	COG0737	Belongs to the 5'-nucleotidase family
CE456_07605	COG2200	EAL domain
CE456_07620	COG0305	Participates in initiation and elongation during chromosome replication
CE456_07625	COG0305	Participates in initiation and elongation during chromosome replication
CE456_07630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE456_07635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE456_07645	COG2199	diguanylate cyclase activity
CE456_07645	COG2200	EAL domain
CE456_07645	COG2203	Gaf domain
CE456_07690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE456_07695	COG2201	protein-glutamate methylesterase activity
CE456_07725	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE456_07730	COG3328	transposase activity
CE456_07740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE456_07745	COG2375	cellular response to nickel ion
CE456_07750	COG1538	Outer membrane efflux protein
CE456_07755	COG0577	efflux transmembrane transporter activity
CE456_07755	COG1136	(ABC) transporter
CE456_07760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_07770	COG1227	inorganic diphosphatase activity
CE456_07775	COG0497	DNA recombination
CE456_07780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CE456_07785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CE456_07790	COG0443	Heat shock 70 kDa protein
CE456_07795	COG0484	heat shock protein binding
CE456_07825	COG1285	pathogenesis
CE456_07840	COG0640	Transcriptional regulator
CE456_07875	COG0095	Lipoate-protein ligase
CE456_07915	COG0708	Exodeoxyribonuclease III
CE456_07975	COG2814	Major facilitator Superfamily
CE456_07980	COG0109	protoheme IX farnesyltransferase activity
CE456_07990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE456_07995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE456_08030	COG1609	Transcriptional regulator
CE456_08035	COG1263	PTS System
CE456_08035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE456_08055	COG5433	transposase activity
CE456_08070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_08090	COG0538	isocitrate dehydrogenase activity
CE456_08135	COG0582	viral genome integration into host DNA
CE456_08145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CE456_08150	COG2867	negative regulation of translational initiation
CE456_08160	COG0702	epimerase
CE456_08165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE456_08195	COG4964	Belongs to the GSP D family
CE456_08205	COG2894	cell division
CE456_08245	COG1454	alcohol dehydrogenase
CE456_08260	COG1957	nucleoside hydrolase
CE456_08280	COG0840	transmembrane signaling receptor activity
CE456_08285	COG1280	lysine exporter protein (LysE YggA)
CE456_08295	COG5433	transposase activity
CE456_08300	COG4580	involved in the transport of maltose and maltodextrins
CE456_08310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE456_08310	COG1263	PTS System
CE456_08320	COG2171	N-acyltransferase activity
CE456_08330	COG0024	Methionine aminopeptidase
CE456_08335	COG0052	Belongs to the universal ribosomal protein uS2 family
CE456_08340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CE456_08345	COG0528	UMP kinase activity
CE456_08350	COG0233	cytoplasmic translational termination
CE456_08355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CE456_08360	COG0575	Belongs to the CDS family
CE456_08365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CE456_08370	COG0750	zinc metalloprotease
CE456_08385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE456_08390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE456_08395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE456_08400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE456_08405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CE456_08415	COG0825	malonyl-CoA metabolic process
CE456_08420	COG3710	Transcriptional regulator
CE456_08425	COG0531	amino acid
CE456_08430	COG1982	Orn Lys Arg decarboxylase major
CE456_08435	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE456_08450	COG0814	amino acid
CE456_08455	COG0531	amino acid
CE456_08465	COG0488	(ABC) transporter
CE456_08475	COG3590	peptidase
CE456_08480	COG0037	tRNA processing
CE456_08485	COG3706	GGDEF domain
CE456_08520	COG0366	Alpha amylase catalytic
CE456_08530	COG1881	PFAM PEBP family protein
CE456_08540	COG0583	DNA-binding transcription factor activity
CE456_08550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE456_08560	COG0583	DNA-binding transcription factor activity
CE456_08565	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_08570	COG0616	signal peptide processing
CE456_08575	COG3724	N-succinylarginine dihydrolase activity
CE456_08580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE456_08590	COG0840	transmembrane signaling receptor activity
CE456_08600	COG2971	BadF BadG BcrA BcrD
CE456_08610	COG4608	Belongs to the ABC transporter superfamily
CE456_08615	COG0444	Belongs to the ABC transporter superfamily
CE456_08620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE456_08670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CE456_08675	COG1289	transmembrane transporter activity
CE456_08680	COG0303	'Molybdopterin
CE456_08685	COG0746	molybdenum cofactor guanylyltransferase activity
CE456_08695	COG4662	Binding-protein-dependent transport system inner membrane component
CE456_08710	COG3852	Histidine kinase
CE456_08720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE456_08735	COG5433	transposase activity
CE456_08765	COG5433	transposase activity
CE456_08795	COG3383	formate dehydrogenase (NAD+) activity
CE456_08800	COG0437	4 iron, 4 sulfur cluster binding
CE456_08815	COG0281	malic enzyme
CE456_08825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_08845	COG0281	malic enzyme
CE456_08850	COG3290	protein histidine kinase activity
CE456_08865	COG0667	Aldo Keto reductase
CE456_08875	COG0697	spore germination
CE456_08895	COG2267	carboxylic ester hydrolase activity
CE456_08900	COG1942	4-Oxalocrotonate Tautomerase
CE456_08905	COG1012	belongs to the aldehyde dehydrogenase family
CE456_08910	COG3284	Transcriptional regulator
CE456_08915	COG3706	GGDEF domain
CE456_08920	COG0346	lactoylglutathione lyase activity
CE456_08925	COG0745	RESPONSE REGULATOR receiver
CE456_08930	COG5002	protein histidine kinase activity
CE456_08940	COG4783	chaperone-mediated protein folding
CE456_08950	COG1940	carbohydrate kinase activity
CE456_08955	COG3142	Participates in the control of copper homeostasis
CE456_08960	COG0545	Peptidyl-prolyl cis-trans isomerase
CE456_08965	COG1131	(ABC) transporter
CE456_08985	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CE456_09005	COG0019	diaminopimelate decarboxylase activity
CE456_09010	COG1115	amino acid carrier protein
CE456_09015	COG0095	Lipoate-protein ligase
CE456_09020	COG2233	PERMEase
CE456_09025	COG3706	GGDEF domain
CE456_09025	COG0745	RESPONSE REGULATOR receiver
CE456_09035	COG0534	Mate efflux family protein
CE456_09040	COG2207	Transcriptional regulator
CE456_09045	COG0281	malic enzyme
CE456_09050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CE456_09050	COG2885	chlorophyll binding
CE456_09080	COG0733	neurotransmitter:sodium symporter activity
CE456_09085	COG1752	Esterase of the alpha-beta hydrolase superfamily
CE456_09090	COG3706	GGDEF domain
CE456_09095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_09100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE456_09110	COG1032	radical SAM domain protein
CE456_09125	COG5433	transposase activity
CE456_09140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE456_09145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE456_09150	COG1196	nuclear chromosome segregation
CE456_09150	COG0741	lytic transglycosylase activity
CE456_09150	COG0739	heme binding
CE456_09155	COG0366	Alpha amylase catalytic
CE456_09175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE456_09185	COG0788	formyltetrahydrofolate deformylase activity
CE456_09190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE456_09200	COG3118	belongs to the thioredoxin family
CE456_09205	COG2091	lysine biosynthetic process via aminoadipic acid
CE456_09210	COG0791	NLP P60 protein
CE456_09215	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CE456_09230	COG1388	LysM domain
CE456_09230	COG1376	ErfK ybiS ycfS ynhG family protein
CE456_09280	COG1960	acyl-CoA dehydrogenase activity
CE456_09285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE456_09295	COG0469	pyruvate kinase activity
CE456_09300	COG1737	Transcriptional regulator
CE456_09325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE456_09345	COG1342	Belongs to the UPF0251 family
CE456_09395	COG1987	bacterial-type flagellum assembly
CE456_09400	COG1684	flagellar biosynthetic protein fliR
CE456_09410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE456_09420	COG0455	bacterial-type flagellum organization
CE456_09435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CE456_09445	COG0450	alkyl hydroperoxide reductase
CE456_09465	COG0500	methyltransferase
CE456_09470	COG4106	trans-aconitate 2-methyltransferase activity
CE456_09490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CE456_09495	COG0217	transcriptional regulatory protein
CE456_09555	COG1940	carbohydrate kinase activity
CE456_09555	COG1846	Transcriptional regulator
CE456_09560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CE456_09565	COG0363	glucosamine-6-phosphate deaminase activity
CE456_09585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE456_09590	COG0735	belongs to the Fur family
CE456_09600	COG0716	FMN binding
CE456_09615	COG0596	Alpha beta hydrolase
CE456_09620	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CE456_09625	COG0033	Phosphoglucomutase
CE456_09635	COG1846	Transcriptional regulator
CE456_09640	COG2951	lytic endotransglycosylase activity
CE456_09645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CE456_09650	COG4136	ATPase activity
CE456_09655	COG4135	transport system, permease component
CE456_09660	COG4134	Bacterial extracellular solute-binding protein
CE456_09670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE456_09680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE456_09685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE456_09700	COG0729	surface antigen
CE456_09705	COG2911	Protein conserved in bacteria
CE456_09720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CE456_09745	COG1607	acyl-coa hydrolase
CE456_09755	COG3021	interspecies interaction between organisms
CE456_09760	COG1388	LysM domain
CE456_09760	COG0741	lytic transglycosylase activity
CE456_09765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE456_09770	COG2226	methyltransferase
CE456_09775	COG0328	RNA-DNA hybrid ribonuclease activity
CE456_09780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE456_09790	COG3437	response regulator, receiver
CE456_09790	COG0784	Response regulator, receiver
CE456_09795	COG1960	acyl-CoA dehydrogenase activity
CE456_09800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE456_09805	COG0121	glutamine amidotransferase
CE456_09825	COG2205	protein histidine kinase activity
CE456_09825	COG0784	Response regulator, receiver
CE456_09835	COG2197	response regulator
CE456_09840	COG3850	Histidine kinase
CE456_09845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CE456_09850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE456_09860	COG0243	molybdopterin cofactor binding
CE456_09865	COG0437	4 iron, 4 sulfur cluster binding
CE456_09870	COG0348	domain, Protein
CE456_09880	COG3005	denitrification pathway
CE456_09885	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE456_09890	COG0315	cyclic pyranopterin monophosphate synthase activity
CE456_09895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CE456_09900	COG0314	molybdopterin synthase activity
CE456_09915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE456_09920	COG0596	Alpha beta hydrolase
CE456_09945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE456_09955	COG0302	gtp cyclohydrolase
CE456_09960	COG0840	transmembrane signaling receptor activity
CE456_09965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CE456_09975	COG0583	DNA-binding transcription factor activity
CE456_09980	COG2353	YceI-like domain
CE456_10005	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE456_10015	COG1166	arginine decarboxylase activity
CE456_10030	COG0346	lactoylglutathione lyase activity
CE456_10040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CE456_10045	COG1187	pseudouridine synthase activity
CE456_10050	COG2807	transmembrane transport
CE456_10060	COG0583	DNA-binding transcription factor activity
CE456_10080	COG2979	Protein of unknown function (DUF533)
CE456_10085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE456_10115	COG2814	Major facilitator Superfamily
CE456_10120	COG0656	L-ascorbic acid biosynthetic process
CE456_10125	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CE456_10150	COG0583	DNA-binding transcription factor activity
CE456_10155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CE456_10160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE456_10165	COG2271	Major facilitator Superfamily
CE456_10170	COG1349	DNA-binding transcription factor activity
CE456_10180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE456_10185	COG0584	glycerophosphoryl diester phosphodiesterase
CE456_10190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE456_10195	COG0287	Prephenate dehydrogenase
CE456_10195	COG1605	Chorismate mutase
CE456_10200	COG0583	DNA-binding transcription factor activity
CE456_10205	COG3085	chromosome segregation
CE456_10230	COG1770	oligopeptidase
CE456_10250	COG3083	sulfuric ester hydrolase activity
CE456_10255	COG3082	Protein of unknown function (DUF1414)
CE456_10260	COG3081	Nucleoid-associated protein
CE456_10265	COG2182	Extracellular solute-binding protein
CE456_10270	COG1175	transmembrane transport
CE456_10280	COG3842	ATPase activity
CE456_10295	COG0628	permease
CE456_10300	COG0425	Belongs to the sulfur carrier protein TusA family
CE456_10305	COG4783	chaperone-mediated protein folding
CE456_10315	COG1393	Belongs to the ArsC family
CE456_10330	COG2431	L-lysine efflux transmembrane transporter activity
CE456_10345	COG4215	(ABC) transporter
CE456_10365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE456_10375	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE456_10385	COG4953	penicillin-binding protein 1C
CE456_10395	COG0301	tRNA thio-modification
CE456_10395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE456_10410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE456_10440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE456_10450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CE456_10470	COG0483	inositol monophosphate 1-phosphatase activity
CE456_10480	COG0625	glutathione transferase activity
CE456_10490	COG0601	transmembrane transport
CE456_10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE456_10500	COG0444	Belongs to the ABC transporter superfamily
CE456_10505	COG2814	Major facilitator Superfamily
CE456_10510	COG0583	DNA-binding transcription factor activity
CE456_10515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE456_10520	COG0243	molybdopterin cofactor binding
CE456_10540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE456_10545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE456_10550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CE456_10555	COG0509	glycine decarboxylation via glycine cleavage system
CE456_10560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE456_10560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE456_10575	COG3634	alkyl hydroperoxide reductase activity
CE456_10580	COG0450	alkyl hydroperoxide reductase
CE456_10585	COG0517	IMP dehydrogenase activity
CE456_10590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CE456_10595	COG0343	queuine tRNA-ribosyltransferase activity
CE456_10600	COG1862	Preprotein translocase
CE456_10605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE456_10610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE456_10615	COG2897	thiosulfate sulfurtransferase activity
CE456_10650	COG1959	2 iron, 2 sulfur cluster binding
CE456_10655	COG1104	cysteine desulfurase activity
CE456_10660	COG0822	iron-sulfur transferase activity
CE456_10670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE456_10675	COG0443	Heat shock 70 kDa protein
CE456_10680	COG0633	Ferredoxin
CE456_10690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE456_10695	COG0105	UTP biosynthetic process
CE456_10700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CE456_10710	COG1426	Protein conserved in bacteria
CE456_10715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CE456_10720	COG0124	histidyl-tRNA synthetase
CE456_10725	COG2976	Protein conserved in bacteria
CE456_10730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE456_10735	COG1160	GTP binding
CE456_10740	COG1645	bacterial-type flagellum-dependent swarming motility
CE456_10745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE456_10750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CE456_10750	COG0047	phosphoribosylformylglycinamidine synthase activity
CE456_10775	COG5433	transposase activity
CE456_10800	COG1242	4 iron, 4 sulfur cluster binding
CE456_10870	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE456_10875	COG1288	antiporter activity
CE456_10880	COG0436	Aminotransferase
CE456_10890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CE456_10895	COG2027	D-alanyl-D-alanine carboxypeptidase
CE456_10900	COG1061	Type III restriction enzyme res subunit
CE456_10905	COG1566	PFAM secretion protein HlyD family protein
CE456_10915	COG1966	Carbon starvation protein
CE456_10920	COG3279	Response regulator of the LytR AlgR family
CE456_10925	COG3275	phosphorelay sensor kinase activity
CE456_10945	COG1454	alcohol dehydrogenase
CE456_10945	COG1012	belongs to the aldehyde dehydrogenase family
CE456_10955	COG2095	MarC family integral membrane protein
CE456_10965	COG0601	transmembrane transport
CE456_10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE456_10975	COG0444	Belongs to the ABC transporter superfamily
CE456_10990	COG0861	Integral membrane protein TerC family
CE456_10995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE456_11005	COG1301	dicarboxylic acid transport
CE456_11020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE456_11035	COG0537	adenosine 5'-monophosphoramidase activity
CE456_11070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE456_11075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE456_11090	COG5433	transposase activity
CE456_11105	COG1007	ATP synthesis coupled electron transport
CE456_11110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11120	COG0713	ATP synthesis coupled electron transport
CE456_11125	COG0839	Belongs to the complex I subunit 6 family
CE456_11130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CE456_11140	COG1034	ATP synthesis coupled electron transport
CE456_11155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11155	COG0649	NAD binding
CE456_11160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11170	COG1360	Flagellar Motor Protein
CE456_11190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CE456_11205	COG4597	amino acid ABC transporter
CE456_11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_11215	COG0765	amino acid transport
CE456_11220	COG1126	abc transporter atp-binding protein
CE456_11230	COG0724	RNA recognition motif
CE456_11235	COG4989	oxidoreductase activity
CE456_11265	COG0583	DNA-binding transcription factor activity
CE456_11280	COG5001	Diguanylate cyclase
CE456_11280	COG3300	MHYT domain
CE456_11300	COG2814	Major facilitator Superfamily
CE456_11315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE456_11320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CE456_11325	COG0539	negative regulation of cytoplasmic translation
CE456_11330	COG0776	regulation of translation
CE456_11340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CE456_11345	COG0284	orotidine-5'-phosphate decarboxylase activity
CE456_11360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CE456_11365	COG0602	queuosine metabolic process
CE456_11370	COG3530	Putative quorum-sensing-regulated virulence factor
CE456_11375	COG2096	Adenosyltransferase
CE456_11380	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE456_11395	COG1757	Na H antiporter
CE456_11400	COG1435	thymidine kinase activity
CE456_11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE456_11440	COG5433	transposase activity
CE456_11450	COG0437	4 iron, 4 sulfur cluster binding
CE456_11455	COG5557	Pfam Polysulphide reductase, NrfD
CE456_11460	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CE456_11465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CE456_11470	COG1773	rubredoxin
CE456_11480	COG0601	transmembrane transport
CE456_11485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE456_11500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CE456_11505	COG0375	protein maturation
CE456_11510	COG0309	Hydrogenase expression formation protein (HypE)
CE456_11520	COG0298	carbon dioxide binding
CE456_11525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CE456_11535	COG1921	L-seryl-tRNASec selenium transferase activity
CE456_11550	COG3260	NADH ubiquinone oxidoreductase 20
CE456_11555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE456_11560	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CE456_11560	COG3261	NADH dehydrogenase
CE456_11565	COG0650	Formate hydrogenlyase subunit 4
CE456_11570	COG0651	ATP synthesis coupled electron transport
CE456_11575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE456_11630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CE456_11635	COG0326	Molecular chaperone. Has ATPase activity
CE456_11645	COG0563	adenylate kinase activity
CE456_11650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CE456_11655	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CE456_11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE456_11665	COG0840	transmembrane signaling receptor activity
CE456_11720	COG1021	2,3-dihydroxybenzoate-AMP ligase
CE456_11725	COG3433	isochorismatase activity
CE456_11725	COG1535	isochorismatase
CE456_11730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE456_11735	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_11750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE456_11755	COG2977	Belongs to the P-Pant transferase superfamily
CE456_11760	COG1120	ATPase activity
CE456_11765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE456_11770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE456_11775	COG4771	TonB-dependent receptor
CE456_11795	COG0598	Magnesium transport protein CorA
CE456_11815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CE456_11820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CE456_11825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE456_11840	COG1570	exodeoxyribonuclease VII activity
CE456_11860	COG5433	transposase activity
CE456_11885	COG0516	GMP reductase activity
CE456_11885	COG0517	IMP dehydrogenase activity
CE456_11890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE456_11890	COG0519	Catalyzes the synthesis of GMP from XMP
CE456_11950	COG2062	phosphohistidine phosphatase, SixA
CE456_11960	COG0697	spore germination
CE456_11965	COG4166	transmembrane transport
CE456_11970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CE456_11975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CE456_11985	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE456_11990	COG1136	(ABC) transporter
CE456_11995	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE456_12000	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CE456_12015	COG0544	peptidyl-prolyl cis-trans isomerase activity
CE456_12020	COG0740	serine-type endopeptidase activity
CE456_12025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CE456_12030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE456_12035	COG0776	regulation of translation
CE456_12040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE456_12045	COG0488	(ABC) transporter
CE456_12050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE456_12055	COG3162	membrane
CE456_12070	COG1024	Enoyl-CoA hydratase
CE456_12070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE456_12075	COG1115	amino acid carrier protein
CE456_12080	COG0456	acetyltransferase
CE456_12090	COG1584	GPR1 FUN34 yaaH family protein
CE456_12120	COG1024	Enoyl-CoA hydratase
CE456_12125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE456_12150	COG1960	acyl-CoA dehydrogenase activity
CE456_12155	COG1024	Enoyl-CoA hydratase
CE456_12160	COG1024	Enoyl-CoA hydratase
CE456_12170	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_12180	COG0730	response to heat
CE456_12215	COG2378	regulation of single-species biofilm formation
CE456_12225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CE456_12225	COG0140	phosphoribosyl-ATP diphosphatase activity
CE456_12230	COG0107	imidazoleglycerol-phosphate synthase activity
CE456_12235	COG2205	protein histidine kinase activity
CE456_12235	COG0784	Response regulator, receiver
CE456_12235	COG2198	Histidine kinase
CE456_12245	COG3437	response regulator, receiver
CE456_12250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CE456_12255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CE456_12260	COG0131	Imidazoleglycerol-phosphate dehydratase
CE456_12260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE456_12265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CE456_12270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CE456_12275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CE456_12285	COG1199	ATP-dependent helicase activity
CE456_12290	COG1214	PFAM Peptidase M22, glycoprotease
CE456_12300	COG2267	carboxylic ester hydrolase activity
CE456_12305	COG0318	PFAM AMP-dependent synthetase and ligase
CE456_12325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE456_12330	COG2832	Protein of unknown function (DUF454)
CE456_12335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CE456_12340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CE456_12345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CE456_12355	COG2197	response regulator
CE456_12365	COG1643	Atp-dependent helicase
CE456_12375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CE456_12380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE456_12385	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CE456_12390	COG0709	Synthesizes selenophosphate from selenide and ATP
CE456_12405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE456_12415	COG1254	Belongs to the acylphosphatase family
CE456_12420	COG0625	glutathione transferase activity
CE456_12425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE456_12425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE456_12430	COG0489	protein tyrosine kinase activity
CE456_12435	COG0572	uridine kinase
CE456_12440	COG0717	Belongs to the dCTP deaminase family
CE456_12445	COG0306	phosphate transporter
CE456_12450	COG1530	ribonuclease E activity
CE456_12460	COG0546	phosphoglycolate phosphatase activity
CE456_12465	COG0424	maF-like protein
CE456_12470	COG1399	metal-binding, possibly nucleic acid-binding protein
CE456_12475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CE456_12480	COG0416	fatty acid biosynthetic process
CE456_12485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE456_12495	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_12500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE456_12505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE456_12510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE456_12515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CE456_12520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CE456_12525	COG0470	DNA polymerase III
CE456_12530	COG0084	hydrolase, TatD family'
CE456_12545	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CE456_12545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE456_12555	COG2995	paraquat-inducible protein a
CE456_12565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CE456_12570	COG0372	Belongs to the citrate synthase family
CE456_12615	COG4221	oxidoreductase activity
CE456_12645	COG3620	sequence-specific DNA binding
CE456_12710	COG5433	transposase activity
CE456_12720	COG1067	ATP-dependent peptidase activity
CE456_12725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE456_12750	COG0116	Belongs to the methyltransferase superfamily
CE456_12750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE456_12765	COG0167	dihydroorotate dehydrogenase activity
CE456_12775	COG5433	transposase activity
CE456_12790	COG0308	aminopeptidase N
CE456_12800	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CE456_12805	COG1956	GAF domain-containing protein
CE456_12815	COG3278	Belongs to the heme-copper respiratory oxidase family
CE456_12830	COG2010	Cytochrome c
CE456_12840	COG2217	Heavy metal translocating P-type atpase
CE456_12855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE456_12860	COG0589	response to stress
CE456_12865	COG0037	tRNA processing
CE456_12885	COG1869	D-ribose catabolic process
CE456_12895	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE456_12900	COG1879	ABC-type sugar transport system periplasmic component
CE456_12905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE456_12910	COG1609	Transcriptional regulator
CE456_12930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CE456_12945	COG2205	protein histidine kinase activity
CE456_12945	COG0784	Response regulator, receiver
CE456_12950	COG0776	regulation of translation
CE456_12955	COG0072	phenylalanine-tRNA ligase activity
CE456_12955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE456_12960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CE456_12965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CE456_12970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CE456_12975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CE456_12980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CE456_13000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE456_13010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE456_13015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE456_13020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE456_13025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CE456_13030	COG3313	Fe-S protein
CE456_13035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_13035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CE456_13035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_13040	COG1105	Belongs to the carbohydrate kinase PfkB family
CE456_13045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_13045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_13050	COG1609	Transcriptional regulator
CE456_13055	COG0814	amino acid
CE456_13065	COG5654	RES domain protein
CE456_13070	COG0513	Belongs to the DEAD box helicase family
CE456_13080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CE456_13085	COG2890	protein-(glutamine-N5) methyltransferase activity
CE456_13090	COG2840	Smr protein MutS2
CE456_13095	COG3706	GGDEF domain
CE456_13145	COG2824	Alkylphosphonate utilization operon protein PhnA
CE456_13150	COG1024	Enoyl-CoA hydratase
CE456_13150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE456_13155	COG0183	Belongs to the thiolase family
CE456_13160	COG0714	Associated with various cellular activities
CE456_13200	COG2067	long-chain fatty acid transport protein
CE456_13205	COG2067	long-chain fatty acid transport protein
CE456_13210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CE456_13230	COG3123	guanosine phosphorylase activity
CE456_13235	COG1760	l-serine dehydratase
CE456_13245	COG1760	l-serine dehydratase
CE456_13250	COG2951	lytic endotransglycosylase activity
CE456_13255	COG3100	YcgL domain-containing protein
CE456_13260	COG0850	regulation of cytokinetic process
CE456_13265	COG2894	cell division
CE456_13270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CE456_13325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CE456_13330	COG0697	spore germination
CE456_13340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE456_13350	COG0307	riboflavin synthase, alpha
CE456_13360	COG0534	Mate efflux family protein
CE456_13395	COG0417	DNA replication proofreading
CE456_13425	COG1560	Kdo2-lipid A biosynthetic process
CE456_13435	COG0583	DNA-binding transcription factor activity
CE456_13440	COG0673	inositol 2-dehydrogenase activity
CE456_13445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CE456_13450	COG0583	DNA-binding transcription factor activity
CE456_13460	COG2723	6-phospho-beta-galactosidase activity
CE456_13465	COG0583	DNA-binding transcription factor activity
CE456_13485	COG1288	antiporter activity
CE456_13495	COG3134	Outer membrane lipoprotein
CE456_13515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE456_13535	COG4681	YaeQ
CE456_13580	COG0242	peptide deformylase activity
CE456_13605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE456_13610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CE456_13615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CE456_13625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE456_13635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CE456_13645	COG0205	6-phosphofructokinase activity
CE456_13680	COG1011	Hydrolase
CE456_13735	COG3593	DNA synthesis involved in DNA repair
CE456_13750	COG0583	DNA-binding transcription factor activity
CE456_13755	COG0730	response to heat
CE456_13770	COG1181	Belongs to the D-alanine--D-alanine ligase family
CE456_13780	COG0386	Belongs to the glutathione peroxidase family
CE456_13785	COG0513	Belongs to the DEAD box helicase family
CE456_13800	COG1742	UPF0060 membrane protein
CE456_13835	COG2329	Antibiotic biosynthesis monooxygenase
CE456_13840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE456_13860	COG3243	poly(R)-hydroxyalkanoic acid synthase
CE456_13870	COG2501	S4 domain
CE456_13880	COG1132	(ABC) transporter
CE456_13895	COG3118	belongs to the thioredoxin family
CE456_13900	COG0471	metal ion transport
CE456_13905	COG0058	SHG alpha-glucan phosphorylase activity
CE456_13950	COG5433	transposase activity
CE456_13975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE456_13985	COG0814	amino acid
CE456_13990	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CE456_13995	COG0514	ATP-dependent DNA helicase (RecQ)
CE456_14000	COG2766	serine protein kinase
CE456_14010	COG2719	SpoVR family
CE456_14015	COG2186	Transcriptional regulator
CE456_14020	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE456_14025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CE456_14030	COG0586	Pfam SNARE associated Golgi protein
CE456_14040	COG0556	nucleotide-excision repair
CE456_14055	COG0569	domain protein
CE456_14055	COG2985	domain, Protein
CE456_14065	COG5433	transposase activity
CE456_14095	COG4565	transcriptional regulatory protein
CE456_14100	COG3290	protein histidine kinase activity
CE456_14105	COG1940	carbohydrate kinase activity
CE456_14105	COG1846	Transcriptional regulator
CE456_14110	COG0840	transmembrane signaling receptor activity
CE456_14115	COG3012	SEC-C Motif Domain Protein
CE456_14120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE456_14125	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CE456_14130	COG0247	lactate metabolic process
CE456_14140	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CE456_14145	COG0437	4 iron, 4 sulfur cluster binding
CE456_14150	COG3301	Polysulphide reductase, NrfD
CE456_14165	COG4235	cytochrome complex assembly
CE456_14165	COG3088	subunit of a heme lyase
CE456_14180	COG3033	Beta-eliminating lyase
CE456_14190	COG3046	protein related to deoxyribodipyrimidine photolyase
CE456_14220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CE456_14225	COG0583	DNA-binding transcription factor activity
CE456_14235	COG4774	siderophore transport
CE456_14240	COG3708	Transcriptional regulator
CE456_14240	COG2207	Transcriptional regulator
CE456_14250	COG0583	DNA-binding transcription factor activity
CE456_14255	COG2910	NAD(P)H-binding
CE456_14275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE456_14280	COG1944	ATP diphosphatase activity
CE456_14285	COG2116	formate transmembrane transporter activity
CE456_14290	COG1882	Formate acetyltransferase
CE456_14300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CE456_14305	COG0045	succinate-CoA ligase (ADP-forming) activity
CE456_14310	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE456_14315	COG0567	Dehydrogenase, E1 component
CE456_14325	COG1053	succinate dehydrogenase
CE456_14330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CE456_14335	COG2009	succinate dehydrogenase
CE456_14355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE456_14360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE456_14360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CE456_14370	COG3069	C4-dicarboxylate transmembrane transporter activity
CE456_14385	COG1451	nucleotide metabolic process
CE456_14400	COG0254	rRNA binding
CE456_14405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE456_14425	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CE456_14430	COG3833	ABC-type maltose transport systems, permease component
CE456_14495	COG4580	involved in the transport of maltose and maltodextrins
CE456_14505	COG1609	Transcriptional regulator
CE456_14510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE456_14530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE456_14540	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE456_14545	COG1129	ABC transporter
CE456_14550	COG1879	ABC-type sugar transport system periplasmic component
CE456_14555	COG1069	ribulokinase activity
CE456_14565	COG2160	L-arabinose isomerase activity
CE456_14570	COG0583	DNA-binding transcription factor activity
CE456_14575	COG0436	Aminotransferase
CE456_14580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE456_14595	COG2925	Exonuclease
CE456_14605	COG3345	alpha-galactosidase
CE456_14615	COG1380	Effector of murein hydrolase LrgA
CE456_14620	COG1346	cytolysis
CE456_14625	COG0295	cytidine deaminase activity
CE456_14630	COG1022	Amp-dependent synthetase and ligase
CE456_14645	COG0861	Integral membrane protein TerC family
CE456_14655	COG2199	diguanylate cyclase activity
CE456_14670	COG2154	pterin-4-alpha-carbinolamine dehydratase
CE456_14680	COG3768	UPF0283 membrane protein
CE456_14685	COG3106	COG3106 Predicted ATPase
CE456_14700	COG1842	Phage shock protein A
CE456_14705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CE456_14715	COG4168	peptide transport system, permease
CE456_14720	COG4171	peptide transport system, permease
CE456_14725	COG4172	Belongs to the ABC transporter superfamily
CE456_14730	COG4172	Belongs to the ABC transporter superfamily
CE456_14740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CE456_14745	COG1286	toxin biosynthetic process
CE456_14750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CE456_14755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CE456_14760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CE456_14765	COG1674	ftsk spoiiie
CE456_14765	COG0531	amino acid
CE456_14785	COG0492	ferredoxin-NADP+ reductase activity
CE456_14795	COG3134	Outer membrane lipoprotein
CE456_14800	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CE456_14805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CE456_14810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CE456_14815	COG0542	response to heat
CE456_14820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CE456_14825	COG1278	Cold shock
CE456_14830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CE456_14955	COG0659	secondary active sulfate transmembrane transporter activity
CE456_15010	COG0697	spore germination
CE456_15015	COG4657	Part of a membrane complex involved in electron transport
CE456_15020	COG2878	Part of a membrane complex involved in electron transport
CE456_15030	COG4658	electron transport chain
CE456_15045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CE456_15050	COG0346	lactoylglutathione lyase activity
CE456_15065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE456_15070	COG2056	Na+-H+ antiporter family
CE456_15075	COG5001	Diguanylate cyclase
CE456_15075	COG3300	MHYT domain
CE456_15085	COG0513	Belongs to the DEAD box helicase family
CE456_15090	COG2050	protein possibly involved in aromatic compounds catabolism
CE456_15100	COG0277	FAD linked oxidase domain protein
CE456_15100	COG0247	lactate metabolic process
CE456_15110	COG1253	flavin adenine dinucleotide binding
CE456_15115	COG1902	pentaerythritol trinitrate reductase activity
CE456_15125	COG0647	UMP catabolic process
CE456_15130	COG4651	solute:proton antiporter activity
CE456_15130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE456_15140	COG0367	asparagine synthase
CE456_15165	COG0625	glutathione transferase activity
CE456_15170	COG0625	glutathione transferase activity
CE456_15195	COG0564	pseudouridine synthase activity
CE456_15215	COG0840	transmembrane signaling receptor activity
CE456_15225	COG0670	Belongs to the BI1 family
CE456_15230	COG1289	transmembrane transporter activity
CE456_15235	COG2920	part of a sulfur-relay system
CE456_15240	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CE456_15245	COG0285	dihydrofolate synthase activity
CE456_15250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CE456_15255	COG0101	tRNA pseudouridine synthase activity
CE456_15265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE456_15270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE456_15275	COG0671	phosphoesterase, PA-phosphatase related
CE456_15305	COG5433	transposase activity
CE456_15340	COG0574	Belongs to the PEP-utilizing enzyme family
CE456_15340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE456_15345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CE456_15400	COG0672	)-iron permease
CE456_15425	COG2814	Major facilitator Superfamily
CE456_15440	COG1136	(ABC) transporter
CE456_15460	COG1285	pathogenesis
CE456_15510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE456_15515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE456_15515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CE456_15520	COG0527	aspartate kinase activity
CE456_15535	COG1619	proteins homologs of microcin C7 resistance protein MccF
CE456_15545	COG0393	Putative heavy-metal-binding
CE456_15550	COG1252	NADH dehydrogenase
CE456_15590	COG0789	Transcriptional regulator
CE456_15605	COG0493	'glutamate synthase
CE456_15610	COG0070	glutamate synthase
CE456_15610	COG0069	glutamate synthase activity
CE456_15610	COG0067	glutamate synthase
CE456_15615	COG5433	transposase activity
CE456_15655	COG0513	Belongs to the DEAD box helicase family
CE456_15660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE456_15690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE456_15695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CE456_15700	COG0505	Belongs to the CarA family
CE456_15705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CE456_15720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CE456_15725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CE456_15730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE456_15735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CE456_15740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE456_15745	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CE456_15755	COG2205	protein histidine kinase activity
CE456_15755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_15795	COG0023	Translation Initiation Factor
CE456_15800	COG2119	membrane
CE456_15830	COG2203	Gaf domain
CE456_15830	COG2199	diguanylate cyclase activity
CE456_15860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE456_15870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE456_15875	COG2261	transglycosylase associated protein
CE456_15915	COG0322	excinuclease ABC activity
CE456_15920	COG2197	response regulator
CE456_15925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CE456_15930	COG2835	tetraacyldisaccharide 4'-kinase activity
CE456_15935	COG1663	tetraacyldisaccharide 4'-kinase activity
CE456_15940	COG1132	(ABC) transporter
CE456_15945	COG2333	competence protein COMEC
CE456_15945	COG0658	competence protein
CE456_15960	COG0433	COG0433 Predicted ATPase
CE456_15965	COG1448	Aminotransferase
CE456_15975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CE456_15995	COG4372	Transposase
CE456_16000	COG1199	ATP-dependent helicase activity
CE456_16020	COG1785	Belongs to the alkaline phosphatase family
CE456_16040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE456_16055	COG2271	Major facilitator Superfamily
CE456_16060	COG3706	GGDEF domain
CE456_16065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_16070	COG0765	amino acid transport
CE456_16075	COG1126	abc transporter atp-binding protein
CE456_16085	COG0531	amino acid
CE456_16100	COG1253	flavin adenine dinucleotide binding
CE456_16105	COG0704	Plays a role in the regulation of phosphate uptake
CE456_16115	COG0581	inorganic phosphate transmembrane transporter activity
CE456_16120	COG0573	inorganic phosphate transmembrane transporter activity
CE456_16125	COG0590	tRNA wobble adenosine to inosine editing
CE456_16135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CE456_16155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CE456_16160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CE456_16165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CE456_16170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CE456_16175	COG2204	response regulator
CE456_16180	COG3852	Histidine kinase
CE456_16200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CE456_16205	COG0248	Ppx GppA phosphatase
CE456_16210	COG2239	Acts as a magnesium transporter
CE456_16240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE456_16245	COG4786	Flagellar basal body rod
CE456_16250	COG4787	bacterial-type flagellum-dependent cell motility
CE456_16265	COG1558	bacterial-type flagellum-dependent cell motility
CE456_16270	COG1815	bacterial-type flagellum-dependent cell motility
CE456_16275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE456_16280	COG0835	chemotaxis
CE456_16280	COG0784	Response regulator, receiver
CE456_16300	COG0622	Phosphoesterase
CE456_16305	COG4166	transmembrane transport
CE456_16315	COG1187	pseudouridine synthase activity
CE456_16335	COG0697	spore germination
CE456_16375	COG1278	Cold shock
CE456_16430	COG3132	Protein of unknown function, DUF480
CE456_16445	COG5433	transposase activity
CE456_16465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE456_16480	COG5433	transposase activity
CE456_16495	COG0471	metal ion transport
CE456_16495	COG3273	potassium ion transport
CE456_16500	COG5433	transposase activity
CE456_16520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CE456_16525	COG0438	transferase activity, transferring glycosyl groups
CE456_16550	COG1450	Type ii and iii secretion system protein
CE456_16585	COG1459	type II secretion system
CE456_16590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE456_16610	COG1091	dTDP-4-dehydrorhamnose reductase activity
CE456_16620	COG1538	Outer membrane efflux protein
CE456_16635	COG1309	transcriptional regulator
CE456_16650	COG1946	Acyl-CoA thioesterase
CE456_16660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CE456_16670	COG0009	L-threonylcarbamoyladenylate synthase
CE456_16675	COG0613	PHP domain protein
CE456_16680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE456_16685	COG0512	Glutamine amidotransferase of anthranilate synthase
CE456_16685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE456_16690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE456_16695	COG0135	phosphoribosylanthranilate isomerase activity
CE456_16695	COG0134	indole-3-glycerol-phosphate synthase activity
CE456_16700	COG0133	tryptophan synthase activity
CE456_16705	COG0159	tryptophan synthase activity
CE456_16760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_16760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_16760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE456_16790	COG0482	sulfurtransferase activity
CE456_16795	COG2915	High frequency lysogenization protein hflD homolog
CE456_16800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CE456_16805	COG2850	peptidyl-arginine hydroxylation
CE456_16860	COG0259	pyridoxamine-phosphate oxidase activity
CE456_16875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE456_16875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE456_16880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CE456_16900	COG4235	cytochrome complex assembly
CE456_16900	COG3088	subunit of a heme lyase
CE456_16905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE456_16910	COG1138	Cytochrome C-type biogenesis protein
CE456_16915	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CE456_16920	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE456_16925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE456_16930	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE456_16945	COG0835	chemotaxis
CE456_16955	COG1192	Involved in chromosome partitioning
CE456_16960	COG1360	Flagellar Motor Protein
CE456_16965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE456_16970	COG2201	protein-glutamate methylesterase activity
CE456_16975	COG2198	Histidine kinase
CE456_16975	COG0643	Histidine kinase
CE456_16985	COG0583	DNA-binding transcription factor activity
CE456_16995	COG0791	NLP P60 protein
CE456_17010	COG1309	transcriptional regulator
CE456_17050	COG0534	Mate efflux family protein
CE456_17060	COG2841	Protein conserved in bacteria
CE456_17065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CE456_17065	COG1013	pyruvate-flavodoxin oxidoreductase activity
CE456_17065	COG0674	pyruvate-flavodoxin oxidoreductase activity
CE456_17065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CE456_17080	COG3217	Mosc domain protein beta barrel domain protein
CE456_17080	COG0633	Ferredoxin
CE456_17080	COG3217	Mosc domain protein beta barrel domain protein
CE456_17080	COG0633	Ferredoxin
CE456_17090	COG0501	Belongs to the peptidase M48B family
CE456_17095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CE456_17100	COG2226	methyltransferase
CE456_17100	COG1073	alpha beta
CE456_17105	COG0156	8-amino-7-oxononanoate synthase activity
CE456_17110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CE456_17130	COG0017	Asparaginyl-tRNA synthetase
CE456_17150	COG0583	DNA-binding transcription factor activity
CE456_17155	COG1393	Belongs to the ArsC family
CE456_17160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CE456_17165	COG1876	peptidase activity
CE456_17175	COG3263	regulation of cellular component size
CE456_17195	COG5433	transposase activity
CE456_17205	COG0564	pseudouridine synthase activity
CE456_17210	COG3098	single-species biofilm formation
CE456_17235	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CE456_17245	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE456_17245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE456_17255	COG3706	GGDEF domain
CE456_17260	COG1611	Belongs to the LOG family
CE456_17265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE456_17270	COG0473	3-isopropylmalate dehydrogenase activity
CE456_17280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CE456_17285	COG2363	Small membrane protein
CE456_17295	COG0583	DNA-binding transcription factor activity
CE456_17300	COG0840	transmembrane signaling receptor activity
CE456_17305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CE456_17320	COG1477	protein flavinylation
CE456_17325	COG2871	sodium ion transport
CE456_17330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE456_17335	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE456_17340	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE456_17345	COG1805	sodium ion transport
CE456_17350	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE456_17355	COG0271	Belongs to the BolA IbaG family
CE456_17365	COG2813	Specifically methylates the guanine in position
CE456_17375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE456_17385	COG2211	Major facilitator Superfamily
CE456_17390	COG3248	Nucleoside-binding outer membrane protein
CE456_17395	COG1666	GTP binding
CE456_17400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CE456_17405	COG0693	protein deglycase activity
CE456_17425	COG3459	Glycosyltransferase 36 associated
CE456_17440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE456_17440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE456_17445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE456_17455	COG1151	hydroxylamine reductase activity
CE456_17460	COG0783	Belongs to the Dps family
CE456_17485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE456_17500	COG0300	oxidoreductase activity
CE456_17510	COG0415	Belongs to the DNA photolyase family
CE456_17515	COG0789	Transcriptional regulator
CE456_17520	COG3272	Protein of unknown function (DUF1722)
CE456_17550	COG0077	Prephenate dehydratase
CE456_17550	COG1605	Chorismate mutase
CE456_17575	COG2133	pyrroloquinoline quinone binding
CE456_17600	COG0300	oxidoreductase activity
CE456_17625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CE456_17640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE456_17650	COG3813	Protein conserved in bacteria
CE456_17675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE456_17705	COG0835	chemotaxis
CE456_17710	COG0840	transmembrane signaling receptor activity
CE456_17740	COG5433	transposase activity
CE456_17745	COG2169	Transcriptional regulator
CE456_17745	COG1917	Cupin 2, conserved barrel domain protein
CE456_17755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE456_17760	COG1396	sequence-specific DNA binding
CE456_17760	COG1917	Cupin 2, conserved barrel domain protein
CE456_17775	COG0531	amino acid
CE456_17780	COG0531	amino acid
CE456_17785	COG1283	sodium-dependent phosphate transmembrane transporter activity
CE456_17795	COG3384	dioxygenase
CE456_17810	COG0813	purine-nucleoside phosphorylase activity
CE456_17835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE456_17840	COG0083	homoserine kinase activity
CE456_17850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CE456_17855	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CE456_17870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE456_17880	COG0745	RESPONSE REGULATOR receiver
CE456_17895	COG4988	ABC transporter
CE456_17900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CE456_17920	COG1720	tRNA m6t6A37 methyltransferase activity
CE456_17940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CE456_17945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_17955	COG2190	(PTS) system
CE456_17960	COG3706	GGDEF domain
CE456_17970	COG3038	cytochrome b561
CE456_17980	COG5433	transposase activity
CE456_17990	COG0419	ATPase involved in DNA repair
CE456_17995	COG0420	3'-5' exonuclease activity
CE456_18005	COG2974	May be involved in recombination
CE456_18010	COG0405	Gamma-glutamyltransferase
CE456_18015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE456_18015	COG4651	solute:proton antiporter activity
CE456_18020	COG4651	solute:proton antiporter activity
CE456_18020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE456_18035	COG0469	pyruvate kinase activity
CE456_18040	COG1196	nuclear chromosome segregation
CE456_18040	COG3264	Mechanosensitive ion channel
CE456_18045	COG0582	viral genome integration into host DNA
CE456_18060	COG1846	Transcriptional regulator
CE456_18065	COG1566	PFAM secretion protein HlyD family protein
CE456_18090	COG0602	queuosine metabolic process
CE456_18100	COG1328	CTP reductase activity
CE456_18110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CE456_18115	COG3115	cell septum assembly
CE456_18120	COG1196	nuclear chromosome segregation
CE456_18130	COG2860	membrane
CE456_18140	COG3108	Peptidase M15
CE456_18145	COG2989	Protein conserved in bacteria
CE456_18160	COG0463	Glycosyl transferase, family 2
CE456_18180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE456_18185	COG0739	heme binding
CE456_18190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CE456_18210	COG5433	transposase activity
CE456_18215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CE456_18225	COG3091	SprT-like family
CE456_18235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CE456_18240	COG0189	ligase activity
CE456_18260	COG1678	Uncharacterized ACR, COG1678
CE456_18265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CE456_18270	COG0583	DNA-binding transcription factor activity
CE456_18285	COG0714	Associated with various cellular activities
CE456_18300	COG1115	amino acid carrier protein
CE456_18305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CE456_18320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CE456_18360	COG2912	Transglutaminase-like superfamily
CE456_18370	COG2890	protein-(glutamine-N5) methyltransferase activity
CE456_18375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CE456_18380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CE456_18385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CE456_18390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CE456_18400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CE456_18405	COG0737	Belongs to the 5'-nucleotidase family
CE456_18410	COG0193	aminoacyl-tRNA hydrolase activity
CE456_18415	COG0012	GTP binding
CE456_18460	COG0490	domain, Protein
CE456_18460	COG0471	metal ion transport
CE456_18470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CE456_18505	COG0443	Heat shock 70 kDa protein
CE456_18520	COG0366	Alpha amylase catalytic
CE456_18535	COG0488	(ABC) transporter
CE456_18555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE456_18565	COG1012	belongs to the aldehyde dehydrogenase family
CE456_18575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CE456_18590	COG0180	Tryptophanyl-tRNA synthetase
CE456_18595	COG0546	phosphoglycolate phosphatase activity
CE456_18600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CE456_18605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CE456_18615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CE456_18620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CE456_18650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CE456_18655	COG0583	DNA-binding transcription factor activity
CE456_18660	COG0840	transmembrane signaling receptor activity
CE456_18675	COG0583	DNA-binding transcription factor activity
CE456_18690	COG0739	heme binding
CE456_18720	COG0584	glycerophosphoryl diester phosphodiesterase
CE456_18730	COG1053	succinate dehydrogenase
CE456_18735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CE456_18740	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE456_18745	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE456_18765	COG3214	Protein conserved in bacteria
CE456_18800	COG0745	RESPONSE REGULATOR receiver
CE456_18805	COG0642	Histidine kinase
CE456_18815	COG0516	GMP reductase activity
CE456_18825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CE456_18835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE456_18855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE456_18870	COG3706	GGDEF domain
CE456_18880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE456_18885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE456_18890	COG1702	phosphate starvation-inducible protein PhoH
CE456_18895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CE456_18900	COG4535	Mg2 and Co2 transporter CorC
CE456_18905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CE456_18910	COG2888	peptidyl-tyrosine sulfation
CE456_18915	COG0495	leucyl-tRNA aminoacylation
CE456_18935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CE456_18940	COG0799	negative regulation of ribosome biogenesis
CE456_18945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CE456_18950	COG0768	penicillin binding
CE456_18955	COG0772	Belongs to the SEDS family
CE456_18960	COG2951	lytic endotransglycosylase activity
CE456_18965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE456_18970	COG1686	Belongs to the peptidase S11 family
CE456_18975	COG2921	Belongs to the UPF0250 family
CE456_18980	COG0321	lipoyl(octanoyl) transferase activity
CE456_18990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CE456_19005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE456_19010	COG3545	Serine hydrolase
CE456_19025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CE456_19035	COG1970	mechanosensitive ion channel activity
CE456_19040	COG3706	GGDEF domain
CE456_19045	COG4974	Belongs to the 'phage' integrase family
CE456_19050	COG0716	FMN binding
CE456_19060	COG0312	modulator of DNA gyrase
CE456_19105	COG5433	transposase activity
CE456_19120	COG1422	Protein of unknown function (DUF1090)
CE456_19125	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CE456_19130	COG3706	GGDEF domain
CE456_19135	COG2211	Major facilitator Superfamily
CE456_19140	COG1185	polyribonucleotide nucleotidyltransferase activity
CE456_19145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CE456_19150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CE456_19155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CE456_19160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CE456_19165	COG0195	Participates in both transcription termination and antitermination
CE456_19170	COG0779	Required for maturation of 30S ribosomal subunits
CE456_19185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CE456_19190	COG0149	triose-phosphate isomerase activity
CE456_19195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CE456_19200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CE456_19205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CE456_19210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CE456_19215	COG1534	Rna-binding protein
CE456_19225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE456_19240	COG1360	Flagellar Motor Protein
CE456_19245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE456_19250	COG1722	exodeoxyribonuclease VII activity
CE456_19255	COG0142	geranyltranstransferase activity
CE456_19260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CE456_19285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CE456_19290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CE456_19295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE456_19300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CE456_19315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE456_19315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE456_19320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CE456_19335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CE456_19355	COG3381	protein complex oligomerization
CE456_19385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE456_19390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE456_19395	COG0511	ligase activity, forming carbon-carbon bonds
CE456_19400	COG0439	Biotin carboxylase
CE456_19405	COG3924	membrane
CE456_19410	COG4145	pantothenate transmembrane transporter activity
CE456_19415	COG2190	(PTS) system
CE456_19415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE456_19415	COG1263	PTS System
CE456_19420	COG0583	DNA-binding transcription factor activity
CE456_19425	COG0604	alcohol dehydrogenase
CE456_19430	COG2264	protein methyltransferase activity
CE456_19435	COG0531	amino acid
CE456_19440	COG4303	Ethanolamine ammonia lyase large subunit
CE456_19445	COG4302	ethanolamine ammonia-lyase activity
CE456_19465	COG0778	Nitroreductase
CE456_19470	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE456_19470	COG1902	pentaerythritol trinitrate reductase activity
CE456_19475	COG0616	signal peptide processing
CE456_19495	COG3139	Protein of unknown function (DUF1315)
CE456_19500	COG0252	asparaginase activity
CE456_19505	COG0786	glutamate:sodium symporter activity
CE456_19520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CE456_19525	COG0384	phenazine biosynthesis protein PhzF
CE456_19530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE456_19535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE456_19540	COG0175	sulfate reduction
CE456_19545	COG2113	Glycine betaine
CE456_19550	COG4176	ABC-type proline glycine betaine transport system permease component
CE456_19555	COG4175	Glycine betaine
CE456_19565	COG3610	response to peptide
CE456_19570	COG2966	Psort location CytoplasmicMembrane, score
CE456_19585	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE456_19595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE456_19600	COG1028	Short-chain dehydrogenase reductase Sdr
CE456_19610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE456_19635	COG2986	histidine ammonia-lyase
CE456_19650	COG0318	PFAM AMP-dependent synthetase and ligase
CE456_19660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE456_19665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE456_19710	COG1858	cytochrome C peroxidase
CE456_19715	COG5433	transposase activity
CE456_19725	COG2313	pseudouridylate synthase activity
CE456_19730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE456_19730	COG1522	sequence-specific DNA binding
CE456_19760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CE456_19765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CE456_19780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CE456_19795	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE456_19805	COG4608	Belongs to the ABC transporter superfamily
CE456_19810	COG0444	Belongs to the ABC transporter superfamily
CE456_19815	COG0747	negative chemotaxis
CE456_19820	COG4239	(ABC) transporter, permease
CE456_19840	COG5433	transposase activity
CE456_19855	COG0811	peptide transport
CE456_19860	COG0811	peptide transport
CE456_19865	COG0848	biopolymer transport protein
CE456_19920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE456_19935	COG1278	Cold shock
CE456_19975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CE456_19985	COG0688	phosphatidylethanolamine metabolic process
CE456_19990	COG4628	conserved protein (DUF2132)
CE456_20010	COG3300	MHYT domain
CE456_20010	COG5001	Diguanylate cyclase
CE456_20015	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CE456_20020	COG4412	M6 family metalloprotease domain protein
CE456_20020	COG3291	Pkd domain containing protein
CE456_20045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CE456_20050	COG1012	belongs to the aldehyde dehydrogenase family
CE456_20065	COG1132	(ABC) transporter
CE456_20075	COG2897	thiosulfate sulfurtransferase activity
CE456_20080	COG2066	Belongs to the glutaminase family
CE456_20085	COG3171	Protein conserved in bacteria
CE456_20090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CE456_20095	COG4935	Belongs to the peptidase S8 family
CE456_20095	COG2234	aminopeptidase activity
CE456_20100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE456_20105	COG2200	EAL domain
CE456_20110	COG1090	epimerase
CE456_20115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CE456_20120	COG4181	ATPase activity
CE456_20125	COG2755	lipolytic protein G-D-S-L family
CE456_20130	COG0784	Response regulator, receiver
CE456_20130	COG0835	chemotaxis
CE456_20140	COG2985	domain, Protein
CE456_20140	COG0569	domain protein
CE456_20145	COG1272	protein, Hemolysin III
CE456_20150	COG0076	glutamate decarboxylase activity
CE456_20155	COG2917	probably involved in intracellular septation
CE456_20160	COG2350	Protein conserved in bacteria
CE456_20170	COG1555	photosystem II stabilization
CE456_20175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CE456_20180	COG3104	oligopeptide transport
CE456_20185	COG0745	RESPONSE REGULATOR receiver
CE456_20215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE456_20230	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CE456_20235	COG1280	lysine exporter protein (LysE YggA)
CE456_20295	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CE456_20315	COG0513	Belongs to the DEAD box helicase family
CE456_20455	COG0582	viral genome integration into host DNA
CE456_20470	COG0795	lipopolysaccharide-transporting ATPase activity
CE456_20475	COG0795	lipopolysaccharide-transporting ATPase activity
CE456_20480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE456_20485	COG2927	DNA polymerase III (CHI subunit)
CE456_20500	COG0586	Pfam SNARE associated Golgi protein
CE456_20505	COG1686	Belongs to the peptidase S11 family
CE456_20530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CE456_20535	COG0527	aspartate kinase activity
CE456_20540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE456_20550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CE456_20555	COG1546	Belongs to the CinA family
CE456_20560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CE456_20600	COG1346	cytolysis
CE456_20615	COG0527	aspartate kinase activity
CE456_20615	COG0460	homoserine dehydrogenase
CE456_20620	COG0626	cystathionine gamma-synthase activity
CE456_20635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE456_20640	COG0814	amino acid
CE456_20645	COG1218	3'(2'),5'-bisphosphate nucleotidase
CE456_20650	COG0494	nUDIX hydrolase
CE456_20655	COG1011	Hydrolase
CE456_20660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE456_20675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CE456_20685	COG3156	type II secretion system protein K
CE456_20690	COG4795	General secretion pathway protein
CE456_20695	COG2165	general secretion pathway protein
CE456_20705	COG2165	general secretion pathway protein
CE456_20710	COG1459	type II secretion system
CE456_20715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE456_20735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CE456_20740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CE456_20760	COG0456	acetyltransferase
CE456_20765	COG3133	Outer membrane lipoprotein
CE456_20780	COG2771	luxR family
CE456_20795	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CE456_20810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_20810	COG2213	PTS system mannitol-specific
CE456_20815	COG0246	Mannitol dehydrogenase
CE456_20820	COG3722	fumarate hydratase activity
CE456_20825	COG3263	regulation of cellular component size
CE456_20830	COG0484	heat shock protein binding
CE456_20850	COG1671	Belongs to the UPF0178 family
CE456_20865	COG1988	membrane-bound metal-dependent
CE456_20870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE456_20880	COG0513	Belongs to the DEAD box helicase family
CE456_20905	COG1575	Belongs to the MenA family. Type 1 subfamily
CE456_20910	COG1169	isochorismate synthase
CE456_20915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CE456_20920	COG0596	Alpha beta hydrolase
CE456_20925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CE456_20935	COG0318	PFAM AMP-dependent synthetase and ligase
CE456_20945	COG5433	transposase activity
CE456_21010	COG5433	transposase activity
CE456_21030	COG2949	membrane
CE456_21045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CE456_21050	COG5380	lipid catabolic process
CE456_21065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CE456_21080	COG2873	o-acetylhomoserine
CE456_21090	COG1979	alcohol dehydrogenase
CE456_21110	COG4221	oxidoreductase activity
CE456_21130	COG1285	pathogenesis
CE456_21150	COG1368	sulfuric ester hydrolase activity
CE456_21155	COG1522	sequence-specific DNA binding
CE456_21165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CE456_21170	COG1418	mRNA catabolic process
CE456_21175	COG1546	Belongs to the CinA family
CE456_21175	COG1058	Belongs to the CinA family
CE456_21185	COG0842	Transport permease protein
CE456_21185	COG1129	ABC transporter
CE456_21210	COG0561	phosphatase activity
CE456_21215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CE456_21225	COG0668	transmembrane transport
CE456_21235	COG1011	Hydrolase
CE456_21250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CE456_21255	COG0019	diaminopimelate decarboxylase activity
CE456_21260	COG1965	Belongs to the frataxin family
CE456_21265	COG0400	carboxylic ester hydrolase activity
CE456_21270	COG3072	Adenylate cyclase
CE456_21275	COG0181	hydroxymethylbilane synthase activity
CE456_21285	COG2959	enzyme of heme biosynthesis
CE456_21300	COG1494	fructose-1,6-bisphosphatase
CE456_21350	COG3932	Exopolysaccharide synthesis, ExoD
CE456_21355	COG0814	amino acid
CE456_21360	COG5433	transposase activity
CE456_21395	COG2022	thiamine diphosphate biosynthetic process
CE456_21405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE456_21410	COG0352	thiamine-phosphate diphosphorylase activity
CE456_21415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CE456_21515	COG3328	transposase activity
CE456_21530	COG2957	Belongs to the agmatine deiminase family
CE456_21540	COG4221	oxidoreductase activity
CE456_21555	COG1024	Enoyl-CoA hydratase
CE456_21565	COG0110	maltose O-acetyltransferase activity
CE456_21575	COG4166	transmembrane transport
CE456_21590	COG1872	DUF167
CE456_21595	COG0762	integral membrane protein
CE456_21600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CE456_21605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CE456_21620	COG3022	response to hydroperoxide
CE456_21625	COG0513	Belongs to the DEAD box helicase family
CE456_21630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CE456_21650	COG0735	belongs to the Fur family
CE456_21655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE456_21670	COG0776	regulation of translation
CE456_21675	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CE456_21700	COG0560	Phosphoserine phosphatase
CE456_21710	COG0813	purine-nucleoside phosphorylase activity
CE456_21715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CE456_21720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CE456_21725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CE456_21740	COG0084	hydrolase, TatD family'
CE456_21760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE456_21765	COG0004	ammonium transporteR
CE456_21800	COG0745	RESPONSE REGULATOR receiver
CE456_21810	COG0189	ligase activity
CE456_21840	COG1639	'signal transduction protein
CE456_21850	COG3700	Belongs to the class B bacterial acid phosphatase family
CE456_21860	COG1366	Belongs to the anti-sigma-factor antagonist family
CE456_21865	COG2172	sigma factor antagonist activity
CE456_21870	COG0784	Response regulator, receiver
CE456_21870	COG2205	protein histidine kinase activity
CE456_21870	COG5002	protein histidine kinase activity
CE456_21875	COG3437	response regulator, receiver
CE456_21885	COG0477	Major facilitator Superfamily
CE456_21900	COG0312	modulator of DNA gyrase
CE456_21905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE456_21915	COG3164	Protein of unknown function
CE456_21920	COG1530	ribonuclease E activity
CE456_21925	COG0424	maF-like protein
CE456_21930	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CE456_21935	COG1792	Involved in formation and maintenance of cell shape
CE456_21940	COG1077	Cell shape determining protein MreB Mrl
CE456_22000	COG2200	EAL domain
CE456_22000	COG2199	diguanylate cyclase activity
CE456_22010	COG0387	Pfam Sodium calcium exchanger
CE456_22015	COG2986	histidine ammonia-lyase
CE456_22020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CE456_22025	COG0010	Belongs to the arginase family
CE456_22030	COG1228	amidohydrolase
CE456_22035	COG2188	Transcriptional regulator
CE456_22040	COG0288	reversible hydration of carbon dioxide
CE456_22050	COG2177	Part of the ABC transporter FtsEX involved in
CE456_22055	COG2884	Cell division ATP-binding protein ftsE
CE456_22060	COG0552	protein localization to endoplasmic reticulum
CE456_22065	COG0742	ribosomal rna small subunit methyltransferase
CE456_22090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE456_22095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE456_22105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE456_22115	COG2095	MarC family integral membrane protein
CE456_22125	COG1301	dicarboxylic acid transport
CE456_22150	COG3714	YhhN family
CE456_22170	COG1770	oligopeptidase
CE456_22185	COG2249	NAD(P)H dehydrogenase (quinone) activity
CE456_22230	COG1987	bacterial-type flagellum assembly
CE456_22255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CE456_22260	COG3107	peptidoglycan biosynthetic process
CE456_22265	COG0792	nuclease activity
CE456_22270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE456_22275	COG2823	Periplasmic or secreted lipoprotein
CE456_22280	COG2969	positive regulation of protein catabolic process
CE456_22285	COG0625	glutathione transferase activity
CE456_22290	COG2857	Cytochrome c1
CE456_22295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CE456_22300	COG0723	plastoquinol--plastocyanin reductase activity
CE456_22305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CE456_22310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CE456_22315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CE456_22325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE456_22330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE456_22365	COG3964	amidohydrolase
CE456_22385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_22390	COG1660	Displays ATPase and GTPase activities
CE456_22395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE456_22405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CE456_22410	COG1137	ATPase activity
CE456_22415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CE456_22420	COG3117	lipopolysaccharide transmembrane transporter activity
CE456_22425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CE456_22430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE456_22430	COG0517	IMP dehydrogenase activity
CE456_22435	COG1127	ABC transporter
CE456_22440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CE456_22445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE456_22450	COG2854	intermembrane phospholipid transfer
CE456_22460	COG5007	Belongs to the BolA IbaG family
CE456_22465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CE456_22470	COG0312	modulator of DNA gyrase
CE456_22475	COG3028	Belongs to the UPF0307 family
CE456_22485	COG2926	Belongs to the UPF0265 family
CE456_22525	COG0203	ribosomal protein L17
CE456_22530	COG0202	RNA polymerase activity
CE456_22535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CE456_22540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CE456_22545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CE456_22550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE456_22555	COG0201	protein transport
CE456_22560	COG0200	Binds to the 23S rRNA
CE456_22565	COG1841	ribosomal large subunit assembly
CE456_22570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CE456_22575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CE456_22580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CE456_22585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CE456_22590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CE456_22595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CE456_22600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CE456_22605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CE456_22610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CE456_22615	COG0255	Belongs to the universal ribosomal protein uL29 family
CE456_22620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CE456_22625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CE456_22630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CE456_22635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CE456_22640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CE456_22645	COG0089	rRNA binding
CE456_22650	COG0088	Forms part of the polypeptide exit tunnel
CE456_22655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CE456_22660	COG0051	transcription antitermination factor activity, RNA binding
CE456_22675	COG0745	RESPONSE REGULATOR receiver
CE456_22680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE456_22685	COG2183	response to ionizing radiation
CE456_22705	COG0596	Alpha beta hydrolase
CE456_22710	COG1040	competence protein
CE456_22715	COG0316	Belongs to the HesB IscA family
CE456_22715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CE456_22720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CE456_22725	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CE456_22730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE456_22735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CE456_22740	COG4942	peptidase
CE456_22750	COG1609	Transcriptional regulator
CE456_22755	COG0800	Aldolase
CE456_22760	COG0129	dihydroxy-acid dehydratase activity
CE456_22765	COG3265	gluconokinase activity
CE456_22770	COG2610	gluconate transmembrane transporter activity
CE456_22775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE456_22780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CE456_22790	COG0456	acetyltransferase
CE456_22800	COG1490	D-aminoacyl-tRNA deacylase activity
CE456_22805	COG1295	ribonuclease BN
CE456_22815	COG0174	glutamine synthetase
CE456_22825	COG3852	Histidine kinase
CE456_22830	COG2204	response regulator
CE456_22835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CE456_22840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE456_22850	COG3078	GTPase activator activity
CE456_22860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CE456_22870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CE456_22875	COG0408	coproporphyrinogen oxidase activity
CE456_22880	COG0009	L-threonylcarbamoyladenylate synthase
CE456_22890	COG0551	DNA topoisomerase type I activity
CE456_22895	COG2922	Belongs to the Smg family
CE456_22900	COG0758	DNA mediated transformation
CE456_22905	COG1652	LysM domain
CE456_22910	COG0242	peptide deformylase activity
CE456_22915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CE456_22920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE456_22920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE456_22925	COG0569	domain protein
CE456_22930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE456_22935	COG1322	Protein conserved in bacteria
CE456_22955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE456_22960	COG0686	Belongs to the AlaDH PNT family
CE456_22965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE456_22965	COG0519	Catalyzes the synthesis of GMP from XMP
CE456_22985	COG1012	belongs to the aldehyde dehydrogenase family
CE456_22995	COG2962	Rard protein
CE456_23005	COG1280	lysine exporter protein (LysE YggA)
CE456_23025	COG2146	nitrite reductase [NAD(P)H] activity
CE456_23030	COG2116	formate transmembrane transporter activity
CE456_23035	COG1648	precorrin-2 dehydrogenase activity
CE456_23035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE456_23040	COG2239	Acts as a magnesium transporter
CE456_23050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE456_23055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CE456_23065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CE456_23075	COG0514	ATP-dependent DNA helicase (RecQ)
CE456_23080	COG2050	protein possibly involved in aromatic compounds catabolism
CE456_23100	COG2258	MOSC domain
CE456_23105	COG1177	transmembrane transport
CE456_23110	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE456_23115	COG3842	ATPase activity
CE456_23135	COG0174	glutamine synthetase
CE456_23140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE456_23155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE456_23160	COG0443	Heat shock 70 kDa protein
CE456_23175	COG0366	Alpha amylase catalytic
CE456_23180	COG1086	Polysaccharide biosynthesis protein
CE456_23185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE456_23210	COG0318	PFAM AMP-dependent synthetase and ligase
CE456_23230	COG1083	cytidylyl-transferase
CE456_23240	COG2089	acid synthase
CE456_23265	COG5433	transposase activity
CE456_23275	COG4310	Domain of unknown function (DUF2172)
CE456_23310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE456_23315	COG0745	RESPONSE REGULATOR receiver
CE456_23320	COG2205	protein histidine kinase activity
CE456_23330	COG0281	malic enzyme
CE456_23335	COG0702	epimerase
CE456_23340	COG0254	rRNA binding
CE456_23345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CE456_23355	COG1309	transcriptional regulator
CE456_23375	COG0129	dihydroxy-acid dehydratase activity
CE456_23380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE456_23385	COG3978	acetolactate synthase activity
CE456_23395	COG0606	chelatase, subunit chli
CE456_23405	COG1683	Conserved Protein
CE456_23415	COG1335	isochorismatase
CE456_23425	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CE456_23430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CE456_23435	COG3639	organic phosphonate transmembrane transporter activity
CE456_23440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE456_23445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CE456_23455	COG3084	Protein conserved in bacteria
CE456_23460	COG2203	Gaf domain
CE456_23460	COG4251	negative regulation of phosphorylation
CE456_23460	COG5001	Diguanylate cyclase
CE456_23460	COG3706	GGDEF domain
CE456_23475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CE456_23485	COG1561	YicC-like family, N-terminal region
CE456_23520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE456_23535	COG1063	alcohol dehydrogenase
CE456_23550	COG0210	DNA helicase
CE456_23555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE456_23560	COG2166	iron-sulfur cluster assembly
CE456_23565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CE456_23595	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CE456_23600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE456_23605	COG1739	Uncharacterized protein family UPF0029
CE456_23615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE456_23620	COG1024	Enoyl-CoA hydratase
CE456_23620	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE456_23625	COG0183	Belongs to the thiolase family
CE456_23630	COG0745	RESPONSE REGULATOR receiver
CE456_23635	COG2205	protein histidine kinase activity
CE456_23650	COG0425	Belongs to the sulfur carrier protein TusA family
CE456_23655	COG0251	oxidation-reduction process
CE456_23660	COG2885	chlorophyll binding
CE456_23670	COG0752	glycyl-tRNA synthetase alpha subunit
CE456_23675	COG0751	glycine-tRNA ligase activity
CE456_23695	COG2188	Transcriptional regulator
CE456_23700	COG3604	Transcriptional regulator
CE456_23710	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE456_23720	COG0348	domain, Protein
CE456_23725	COG0814	amino acid
CE456_23740	COG2199	diguanylate cyclase activity
CE456_23740	COG2200	EAL domain
CE456_23740	COG2202	Pas domain
CE456_23770	COG3328	transposase activity
CE456_23800	COG1609	Transcriptional regulator
CE456_23810	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE456_23840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE456_23865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CE456_23875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CE456_23880	COG3118	belongs to the thioredoxin family
CE456_23885	COG0513	Belongs to the DEAD box helicase family
CE456_23890	COG0248	Ppx GppA phosphatase
CE456_23900	COG0742	ribosomal rna small subunit methyltransferase
CE456_23905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE456_23925	COG0084	hydrolase, TatD family'
CE456_23930	COG0805	protein transport
CE456_23935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE456_23945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CE456_23950	COG3165	ubiquinone biosynthetic process from chorismate
CE456_23960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CE456_23965	COG0402	S-adenosylhomocysteine deaminase activity
CE456_24005	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CE456_24010	COG0848	biopolymer transport protein
CE456_24015	COG0811	peptide transport
CE456_24020	COG0811	peptide transport
CE456_24030	COG2771	luxR family
CE456_24035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CE456_24040	COG1349	DNA-binding transcription factor activity
CE456_24045	COG0745	RESPONSE REGULATOR receiver
CE456_24060	COG4452	Inner membrane protein CreD
CE456_24065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CE456_24070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CE456_24075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CE456_24080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CE456_24085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CE456_24090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CE456_24095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CE456_24105	COG0356	it plays a direct role in the translocation of protons across the membrane
CE456_24110	COG3312	ion transport
CE456_24115	COG1475	DNA binding
CE456_24120	COG1192	Involved in chromosome partitioning
CE456_24125	COG0357	Ribosomal RNA small subunit methyltransferase G
CE456_24130	COG0445	tRNA wobble uridine modification
CE456_24135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE456_24140	COG4774	siderophore transport
CE456_24145	COG4615	Cyclic peptide transporter
CE456_24150	COG1120	ATPase activity
CE456_24155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE456_24165	COG4774	siderophore transport
CE456_24170	COG4607	ABC-type enterochelin transport system periplasmic component
CE456_24175	COG4604	ABC transporter, ATP-binding protein
CE456_24180	COG4605	iron ion homeostasis
CE456_24185	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE456_24205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE456_24215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE456_24230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CE456_24235	COG0706	membrane insertase activity
CE456_24240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CE456_24245	COG0594	ribonuclease P activity
CE456_24250	COG0230	Belongs to the bacterial ribosomal protein bL34 family