locus-tag	class	description
CE462_00115	COG3039	Transposase
CE462_00165	COG2003	Belongs to the UPF0758 family
CE462_00220	COG1192	Involved in chromosome partitioning
CE462_00240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE462_00320	COG1192	Involved in chromosome partitioning
CE462_00340	COG2361	Protein of unknown function DUF86
CE462_00345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE462_00430	COG0457	Tetratricopeptide repeat
CE462_00495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE462_00500	COG4790	Type iii secretion
CE462_00505	COG4794	Type iii secretion
CE462_00510	COG4791	protein targeting
CE462_00515	COG4792	protein secretion
CE462_00550	COG1192	Involved in chromosome partitioning
CE462_00570	COG1484	DNA-dependent DNA replication
CE462_00675	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE462_00685	COG1192	Involved in chromosome partitioning
CE462_00695	COG3328	transposase activity
CE462_00725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE462_00730	COG1317	bacterial-type flagellum organization
CE462_00780	COG1192	Involved in chromosome partitioning
CE462_00805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE462_00810	COG2361	Protein of unknown function DUF86
CE462_00895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CE462_00900	COG0592	DNA-directed DNA polymerase activity
CE462_00910	COG0187	DNA topoisomerase II activity
CE462_00925	COG2378	regulation of single-species biofilm formation
CE462_00930	COG0071	Belongs to the small heat shock protein (HSP20) family
CE462_00935	COG0071	Belongs to the small heat shock protein (HSP20) family
CE462_00950	COG3977	Valine--pyruvate aminotransferase
CE462_00965	COG2814	Major facilitator Superfamily
CE462_00970	COG0745	RESPONSE REGULATOR receiver
CE462_00975	COG2205	protein histidine kinase activity
CE462_01000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE462_01005	COG4191	Histidine kinase
CE462_01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_01010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE462_01015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE462_01020	COG1309	transcriptional regulator
CE462_01050	COG0561	phosphatase activity
CE462_01055	COG2267	carboxylic ester hydrolase activity
CE462_01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE462_01065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE462_01070	COG1758	RNA polymerase activity
CE462_01075	COG0194	GDP metabolic process
CE462_01085	COG0859	PFAM glycosyl transferase family 9
CE462_01090	COG3642	lipopolysaccharide core region biosynthetic process
CE462_01130	COG0589	response to stress
CE462_01135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE462_01145	COG1528	Iron-storage protein
CE462_01150	COG2081	HI0933 family
CE462_01175	COG5433	transposase activity
CE462_01200	COG5433	transposase activity
CE462_01215	COG2205	protein histidine kinase activity
CE462_01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_01225	COG3275	phosphorelay sensor kinase activity
CE462_01230	COG3279	Response regulator of the LytR AlgR family
CE462_01235	COG2223	nitrite transmembrane transporter activity
CE462_01240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CE462_01245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CE462_01260	COG0583	DNA-binding transcription factor activity
CE462_01265	COG4206	TonB-dependent receptor
CE462_01270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CE462_01315	COG0583	DNA-binding transcription factor activity
CE462_01320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CE462_01325	COG0166	Belongs to the GPI family
CE462_01335	COG0668	transmembrane transport
CE462_01340	COG1309	transcriptional regulator
CE462_01345	COG0756	dUTP diphosphatase activity
CE462_01350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CE462_01355	COG2003	Belongs to the UPF0758 family
CE462_01360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CE462_01365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CE462_01375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CE462_01380	COG2990	Protein conserved in bacteria
CE462_01385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CE462_01390	COG0859	PFAM glycosyl transferase family 9
CE462_01395	COG0463	Glycosyl transferase, family 2
CE462_01400	COG0859	PFAM glycosyl transferase family 9
CE462_01405	COG1519	Transferase
CE462_01420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_01425	COG1609	Transcriptional regulator
CE462_01455	COG1580	Controls the rotational direction of flagella during chemotaxis
CE462_01460	COG3161	chorismate lyase activity
CE462_01465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CE462_01470	COG2937	Belongs to the GPAT DAPAT family
CE462_01475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CE462_01490	COG0534	Mate efflux family protein
CE462_01495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CE462_01500	COG2205	protein histidine kinase activity
CE462_01505	COG0745	RESPONSE REGULATOR receiver
CE462_01515	COG1045	serine acetyltransferase
CE462_01525	COG3074	FtsZ-dependent cytokinesis
CE462_01530	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CE462_01545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CE462_01595	COG1609	Transcriptional regulator
CE462_01600	COG0385	Bile acid
CE462_01605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CE462_01625	COG0583	DNA-binding transcription factor activity
CE462_01650	COG0210	DNA helicase
CE462_01690	COG2391	methyltransferase activity
CE462_01695	COG5433	transposase activity
CE462_01705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE462_01720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CE462_01725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CE462_01735	COG0018	arginyl-trna synthetase
CE462_01745	COG1595	DNA-templated transcription, initiation
CE462_01755	COG1968	undecaprenyl-diphosphatase activity
CE462_01760	COG0667	Aldo Keto reductase
CE462_01765	COG2017	converts alpha-aldose to the beta-anomer
CE462_01770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE462_01780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE462_01785	COG1609	Transcriptional regulator
CE462_01790	COG3250	beta-galactosidase activity
CE462_01805	COG4211	Belongs to the binding-protein-dependent transport system permease family
CE462_01815	COG3328	transposase activity
CE462_01845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CE462_01850	COG1288	antiporter activity
CE462_01860	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CE462_01865	COG0540	Belongs to the ATCase OTCase family
CE462_01880	COG0688	phosphatidylethanolamine metabolic process
CE462_01890	COG3040	lipid binding
CE462_01900	COG1979	alcohol dehydrogenase
CE462_01905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CE462_01910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CE462_01920	COG2964	Protein conserved in bacteria
CE462_01925	COG3681	Belongs to the UPF0597 family
CE462_01935	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE462_01940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE462_01945	COG0564	pseudouridine synthase activity
CE462_01955	COG0542	response to heat
CE462_01960	COG2502	aspartate--ammonia ligase
CE462_01965	COG1522	sequence-specific DNA binding
CE462_01975	COG5413	integral membrane protein
CE462_01980	COG0517	IMP dehydrogenase activity
CE462_01980	COG0516	GMP reductase activity
CE462_01985	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_01995	COG2205	protein histidine kinase activity
CE462_02005	COG2204	response regulator
CE462_02020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CE462_02025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CE462_02040	COG0745	RESPONSE REGULATOR receiver
CE462_02045	COG2205	protein histidine kinase activity
CE462_02055	COG0243	molybdopterin cofactor binding
CE462_02060	COG3005	denitrification pathway
CE462_02065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE462_02070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE462_02075	COG0569	domain protein
CE462_02080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CE462_02105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE462_02115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CE462_02120	COG0250	Participates in transcription elongation, termination and antitermination
CE462_02125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CE462_02130	COG0081	regulation of translation
CE462_02135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CE462_02140	COG0222	ribosome binding
CE462_02145	COG0085	RNA polymerase activity
CE462_02150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CE462_02155	COG2964	Protein conserved in bacteria
CE462_02170	COG2923	Belongs to the DsrF TusC family
CE462_02175	COG2168	tRNA wobble position uridine thiolation
CE462_02180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CE462_02185	COG0049	tRNA binding
CE462_02190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CE462_02195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE462_02200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE462_02260	COG3047	cAMP biosynthetic process
CE462_02290	COG3135	benzoate transporter
CE462_02295	COG1396	sequence-specific DNA binding
CE462_02335	COG2252	PERMEase
CE462_02340	COG2376	Dihydroxyacetone kinase
CE462_02345	COG1461	Dihydroxyacetone kinase
CE462_02350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE462_02350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_02350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CE462_02360	COG3284	Transcriptional regulator
CE462_02365	COG0628	permease
CE462_02370	COG0494	nUDIX hydrolase
CE462_02395	COG0753	catalase activity
CE462_02400	COG1247	-acetyltransferase
CE462_02420	COG2203	Gaf domain
CE462_02420	COG2199	diguanylate cyclase activity
CE462_02430	COG3842	ATPase activity
CE462_02440	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE462_02465	COG0583	DNA-binding transcription factor activity
CE462_02475	COG1741	Belongs to the pirin family
CE462_02480	COG2259	Doxx family
CE462_02485	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CE462_02490	COG1074	ATP-dependent DNA helicase activity
CE462_02495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CE462_02515	COG0346	lactoylglutathione lyase activity
CE462_02525	COG5433	transposase activity
CE462_02545	COG0347	Belongs to the P(II) protein family
CE462_02550	COG3706	GGDEF domain
CE462_02550	COG0745	RESPONSE REGULATOR receiver
CE462_02565	COG2205	protein histidine kinase activity
CE462_02570	COG3706	GGDEF domain
CE462_02580	COG1278	Cold shock
CE462_02590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CE462_02595	COG2197	response regulator
CE462_02645	COG2204	response regulator
CE462_02650	COG1677	Flagellar hook-basal body complex protein FliE
CE462_02660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE462_02685	COG2747	anti-sigma28 factor FlgM
CE462_02695	COG1815	bacterial-type flagellum-dependent cell motility
CE462_02700	COG1558	bacterial-type flagellum-dependent cell motility
CE462_02705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CE462_02710	COG1749	Flagellar hook protein flgE
CE462_02715	COG4786	Flagellar basal body rod
CE462_02720	COG4786	Flagellar basal body rod
CE462_02725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE462_02730	COG1706	bacterial-type flagellum-dependent cell motility
CE462_02740	COG1256	bacterial-type flagellum assembly
CE462_02740	COG4786	Flagellar basal body rod
CE462_02760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE462_02770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE462_02775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CE462_02800	COG1191	sigma factor activity
CE462_02805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE462_02810	COG1360	Flagellar Motor Protein
CE462_02820	COG0741	lytic transglycosylase activity
CE462_02820	COG1388	LysM domain
CE462_02830	COG2001	Belongs to the MraZ family
CE462_02835	COG0275	rRNA processing
CE462_02840	COG3116	cell division
CE462_02845	COG0768	penicillin binding
CE462_02855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CE462_02860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE462_02865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CE462_02870	COG0772	Belongs to the SEDS family
CE462_02875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CE462_02880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE462_02885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CE462_02890	COG0849	cell division
CE462_02895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CE462_02900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CE462_02910	COG0653	protein targeting
CE462_02920	COG0494	nUDIX hydrolase
CE462_02925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CE462_02930	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CE462_02940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CE462_02950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE462_02985	COG2186	Transcriptional regulator
CE462_02990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CE462_02995	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE462_03000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE462_03005	COG3447	MASE1 domain protein
CE462_03005	COG5001	Diguanylate cyclase
CE462_03005	COG5002	protein histidine kinase activity
CE462_03015	COG0840	transmembrane signaling receptor activity
CE462_03020	COG0840	transmembrane signaling receptor activity
CE462_03030	COG1049	propionate catabolic process, 2-methylcitrate cycle
CE462_03035	COG2200	EAL domain
CE462_03040	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_03045	COG0583	DNA-binding transcription factor activity
CE462_03055	COG1280	lysine exporter protein (LysE YggA)
CE462_03065	COG0523	cobalamin synthesis protein
CE462_03085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CE462_03090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CE462_03230	COG0784	Response regulator, receiver
CE462_03230	COG0835	chemotaxis
CE462_03235	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_03240	COG1444	tRNA N-acetyltransferase activity
CE462_03265	COG1803	Methylglyoxal synthase
CE462_03280	COG0252	asparaginase activity
CE462_03290	COG1609	Transcriptional regulator
CE462_03300	COG1940	carbohydrate kinase activity
CE462_03305	COG1447	Phosphotransferase system cellobiose-specific component IIA
CE462_03310	COG2723	6-phospho-beta-galactosidase activity
CE462_03315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE462_03315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE462_03320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE462_03325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE462_03340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE462_03340	COG1263	PTS System
CE462_03345	COG0366	Alpha amylase catalytic
CE462_03350	COG0110	maltose O-acetyltransferase activity
CE462_03360	COG1757	Na H antiporter
CE462_03395	COG0297	glycogen (starch) synthase activity
CE462_03400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CE462_03405	COG2813	Specifically methylates the guanine in position
CE462_03410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE462_03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE462_03435	COG2995	paraquat-inducible protein a
CE462_03440	COG3008	intermembrane lipid transfer
CE462_03440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE462_03445	COG3009	Protein conserved in bacteria
CE462_03460	COG3240	lipase activity
CE462_03465	COG3111	PFAM Bacterial OB fold (BOF) protein
CE462_03475	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CE462_03480	COG1194	a g-specific adenine glycosylase
CE462_03490	COG3267	Type II secretory pathway component ExeA
CE462_03490	COG3409	Peptidoglycan-binding domain 1 protein
CE462_03495	COG0617	tRNA 3'-terminal CCA addition
CE462_03500	COG0306	phosphate transporter
CE462_03505	COG1392	Phosphate transport regulator
CE462_03520	COG1560	Kdo2-lipid A biosynthetic process
CE462_03525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CE462_03525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CE462_03530	COG1538	Outer membrane efflux protein
CE462_03535	COG0494	nUDIX hydrolase
CE462_03540	COG3151	Protein conserved in bacteria
CE462_03550	COG3150	esterase
CE462_03555	COG1051	belongs to the nudix hydrolase family
CE462_03565	COG0187	DNA topoisomerase II activity
CE462_03635	COG2259	Doxx family
CE462_03640	COG3118	belongs to the thioredoxin family
CE462_03660	COG0204	Acyl-transferase
CE462_03680	COG2827	Endonuclease containing a URI domain
CE462_03695	COG1573	uracil-dna glycosylase
CE462_03705	COG0583	DNA-binding transcription factor activity
CE462_03710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CE462_03715	COG1121	(ABC) transporter
CE462_03720	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CE462_03740	COG0739	heme binding
CE462_03750	COG3068	Protein conserved in bacteria
CE462_03770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE462_03790	COG0798	PFAM Bile acid sodium symporter
CE462_03795	COG1393	Belongs to the ArsC family
CE462_03805	COG2072	flavoprotein involved in K transport
CE462_03815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CE462_03825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CE462_03830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE462_03840	COG0137	argininosuccinate synthase activity
CE462_03845	COG0165	Argininosuccinate lyase
CE462_03850	COG0583	DNA-binding transcription factor activity
CE462_03860	COG1942	4-Oxalocrotonate Tautomerase
CE462_03890	COG0110	maltose O-acetyltransferase activity
CE462_03895	COG3174	membrane
CE462_03900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CE462_03910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CE462_03920	COG4208	sulfate ABC transporter
CE462_03925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CE462_03930	COG0583	DNA-binding transcription factor activity
CE462_03935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE462_03940	COG0765	amino acid transport
CE462_03950	COG1126	abc transporter atp-binding protein
CE462_03955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_03960	COG3397	chitin binding
CE462_03965	COG0840	transmembrane signaling receptor activity
CE462_04000	COG0726	polysaccharide deacetylase
CE462_04000	COG1649	PFAM Uncharacterised BCR, COG1649
CE462_04005	COG1215	transferase activity, transferring glycosyl groups
CE462_04050	COG1328	CTP reductase activity
CE462_04055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE462_04075	COG1448	Aminotransferase
CE462_04115	COG0513	Belongs to the DEAD box helicase family
CE462_04130	COG3568	Endonuclease Exonuclease Phosphatase
CE462_04135	COG0840	transmembrane signaling receptor activity
CE462_04150	COG3112	Uncharacterised protein family (UPF0231)
CE462_04155	COG3835	regulator
CE462_04160	COG2610	gluconate transmembrane transporter activity
CE462_04165	COG1929	Belongs to the glycerate kinase type-1 family
CE462_04185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE462_04200	COG0347	Belongs to the P(II) protein family
CE462_04205	COG1840	ABC-type Fe3 transport system, periplasmic component
CE462_04215	COG3842	ATPase activity
CE462_04220	COG2837	iron assimilation
CE462_04225	COG1438	arginine binding
CE462_04230	COG1126	abc transporter atp-binding protein
CE462_04235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_04240	COG4215	(ABC) transporter
CE462_04245	COG4160	amino acid transport
CE462_04250	COG0039	L-malate dehydrogenase activity
CE462_04255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CE462_04260	COG1017	nitric oxide dioxygenase activity
CE462_04260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE462_04265	COG1959	2 iron, 2 sulfur cluster binding
CE462_04270	COG4536	flavin adenine dinucleotide binding
CE462_04275	COG4137	Cytochrome C assembly protein
CE462_04280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CE462_04285	COG0228	four-way junction DNA binding
CE462_04290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CE462_04295	COG0336	Belongs to the RNA methyltransferase TrmD family
CE462_04300	COG0335	large ribosomal subunit rRNA binding
CE462_04310	COG3066	DNA modification
CE462_04315	COG1051	belongs to the nudix hydrolase family
CE462_04325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CE462_04330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CE462_04335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE462_04345	COG0583	DNA-binding transcription factor activity
CE462_04350	COG0640	Transcriptional regulator
CE462_04355	COG0268	Binds directly to 16S ribosomal RNA
CE462_04360	COG0728	peptidoglycan biosynthetic process
CE462_04365	COG0196	riboflavin kinase activity
CE462_04370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CE462_04375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CE462_04380	COG1047	Peptidyl-prolyl cis-trans
CE462_04385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CE462_04390	COG4968	Prepilin-type N-terminal cleavage methylation domain
CE462_04425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE462_04425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CE462_04440	COG1854	S-ribosylhomocysteine lyase activity
CE462_04445	COG3706	GGDEF domain
CE462_04450	COG0557	exoribonuclease II activity
CE462_04455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE462_04465	COG2153	protein acetylation
CE462_04485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE462_04490	COG1914	H( )-stimulated, divalent metal cation uptake system
CE462_04495	COG0360	Binds together with S18 to 16S ribosomal RNA
CE462_04500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CE462_04505	COG0359	binds to the 23S rRNA
CE462_04535	COG1064	alcohol dehydrogenase
CE462_04540	COG1238	metal cluster binding
CE462_04545	COG0612	Peptidase, M16
CE462_04550	COG2918	glutathione biosynthetic process
CE462_04560	COG1022	Amp-dependent synthetase and ligase
CE462_04570	COG0456	acetyltransferase
CE462_04580	COG0714	Associated with various cellular activities
CE462_04605	COG0745	RESPONSE REGULATOR receiver
CE462_04605	COG3706	GGDEF domain
CE462_04610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CE462_04620	COG1902	pentaerythritol trinitrate reductase activity
CE462_04630	COG0442	prolyl-tRNA aminoacylation
CE462_04640	COG0632	four-way junction helicase activity
CE462_04645	COG2255	four-way junction helicase activity
CE462_04650	COG1271	oxidase subunit
CE462_04655	COG1294	oxidase, subunit
CE462_04660	COG4890	Cyd operon protein YbgT
CE462_04665	COG3790	cyd operon protein YbgE
CE462_04670	COG0824	Thioesterase
CE462_04675	COG0811	peptide transport
CE462_04690	COG0823	Involved in the tonB-independent uptake of proteins
CE462_04695	COG2885	chlorophyll binding
CE462_04700	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CE462_04765	COG0840	transmembrane signaling receptor activity
CE462_04770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CE462_04775	COG0676	glucose-6-phosphate 1-epimerase activity
CE462_04780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE462_04785	COG1640	4-alpha-glucanotransferase
CE462_04790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CE462_04810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE462_04815	COG4991	sh3 domain protein
CE462_04820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE462_04820	COG0506	proline dehydrogenase activity
CE462_04820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE462_04830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CE462_04835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CE462_04840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE462_04845	COG0163	prenyltransferase activity
CE462_04860	COG1131	(ABC) transporter
CE462_04865	COG0842	Transport permease protein
CE462_04875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CE462_04880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CE462_04885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CE462_04890	COG0617	tRNA 3'-terminal CCA addition
CE462_04895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE462_04900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE462_04905	COG1489	DNA binding
CE462_04915	COG1643	Atp-dependent helicase
CE462_04920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE462_04925	COG0346	lactoylglutathione lyase activity
CE462_04935	COG2076	Multidrug Resistance protein
CE462_04940	COG0583	DNA-binding transcription factor activity
CE462_04945	COG0784	Response regulator, receiver
CE462_04945	COG3437	response regulator, receiver
CE462_04955	COG0671	phosphoesterase, PA-phosphatase related
CE462_04970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CE462_04975	COG0038	chloride channel
CE462_04985	COG0316	Belongs to the HesB IscA family
CE462_05015	COG2816	NAD+ diphosphatase activity
CE462_05020	COG2205	protein histidine kinase activity
CE462_05025	COG0745	RESPONSE REGULATOR receiver
CE462_05030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE462_05045	COG1505	serine-type exopeptidase activity
CE462_05050	COG2982	Protein involved in outer membrane biogenesis
CE462_05060	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_05095	COG1349	DNA-binding transcription factor activity
CE462_05100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CE462_05120	COG2130	NADP-dependent
CE462_05125	COG1764	response to oxidative stress
CE462_05130	COG1846	Transcriptional regulator
CE462_05160	COG0561	phosphatase activity
CE462_05175	COG0733	neurotransmitter:sodium symporter activity
CE462_05185	COG0733	neurotransmitter:sodium symporter activity
CE462_05210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE462_05225	COG1794	racemase activity, acting on amino acids and derivatives
CE462_05235	COG2731	YhcH YjgK YiaL family protein
CE462_05245	COG0668	transmembrane transport
CE462_05250	COG1376	ErfK ybiS ycfS ynhG family protein
CE462_05255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE462_05290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CE462_05300	COG0488	(ABC) transporter
CE462_05305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE462_05305	COG0517	IMP dehydrogenase activity
CE462_05310	COG1585	Membrane protein implicated in regulation of membrane protease activity
CE462_05315	COG0330	HflC and HflK could
CE462_05320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE462_05320	COG1648	precorrin-2 dehydrogenase activity
CE462_05325	COG0175	sulfate reduction
CE462_05330	COG2895	sulfate adenylyltransferase (ATP) activity
CE462_05335	COG3273	potassium ion transport
CE462_05335	COG0471	metal ion transport
CE462_05340	COG0529	Catalyzes the synthesis of activated sulfate
CE462_05345	COG5433	transposase activity
CE462_05410	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CE462_05435	COG1940	carbohydrate kinase activity
CE462_05440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE462_05445	COG0126	phosphoglycerate kinase activity
CE462_05450	COG0191	fructose-bisphosphate aldolase activity
CE462_05455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE462_05505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CE462_05510	COG1595	DNA-templated transcription, initiation
CE462_05515	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CE462_05530	COG0481	GTPase activity
CE462_05535	COG0681	Belongs to the peptidase S26 family
CE462_05540	COG0571	ribonuclease III activity
CE462_05550	COG1381	Involved in DNA repair and RecF pathway recombination
CE462_05555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CE462_05560	COG3023	N-Acetylmuramoyl-L-alanine amidase
CE462_05565	COG4807	Protein conserved in bacteria
CE462_05575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE462_05580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE462_05585	COG3956	TIGRFAM MazG family protein
CE462_05590	COG0504	CTP synthase activity
CE462_05595	COG0148	phosphopyruvate hydratase activity
CE462_05600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CE462_05605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CE462_05615	COG0585	pseudouridine synthase activity
CE462_05620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CE462_05625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE462_05630	COG1238	metal cluster binding
CE462_05635	COG1388	LysM domain
CE462_05635	COG4942	peptidase
CE462_05645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CE462_05650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE462_05655	COG1610	YqeY-like protein
CE462_05660	COG0358	DNA primase activity
CE462_05665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CE462_05705	COG0151	Belongs to the GarS family
CE462_05710	COG0138	bifunctional purine biosynthesis protein purh
CE462_05720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CE462_05725	COG3036	rescue of stalled ribosome
CE462_05730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE462_05735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CE462_05745	COG0673	inositol 2-dehydrogenase activity
CE462_05755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE462_05760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE462_05765	COG3227	Zinc metalloprotease (Elastase)
CE462_05775	COG0477	Major facilitator Superfamily
CE462_05785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CE462_05790	COG1027	Aspartate ammonia-lyase
CE462_05795	COG3030	protein affecting phage T7 exclusion by the F plasmid
CE462_05805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CE462_05810	COG0459	protein refolding
CE462_05820	COG5001	Diguanylate cyclase
CE462_05820	COG3300	MHYT domain
CE462_05830	COG0564	pseudouridine synthase activity
CE462_05835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE462_05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE462_05875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CE462_05880	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CE462_05885	COG1178	ABC-type Fe3 transport system permease component
CE462_05890	COG4143	(ABC) transporter
CE462_05905	COG0066	3-isopropylmalate dehydratase activity
CE462_05910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CE462_05915	COG0473	3-isopropylmalate dehydrogenase activity
CE462_05920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE462_05930	COG0671	phosphoesterase, PA-phosphatase related
CE462_05945	COG0028	Belongs to the TPP enzyme family
CE462_05950	COG0440	acetolactate synthase activity
CE462_05955	COG0280	phosphate acetyltransferase
CE462_05955	COG0857	belongs to the CobB CobQ family
CE462_05965	COG3092	negative regulation of chromosome organization
CE462_05970	COG3013	Belongs to the UPF0304 family
CE462_05975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CE462_05980	COG2716	regulation of RNA biosynthetic process
CE462_05990	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CE462_05995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CE462_06030	COG2198	Histidine kinase
CE462_06030	COG5002	protein histidine kinase activity
CE462_06030	COG0784	Response regulator, receiver
CE462_06055	COG0840	transmembrane signaling receptor activity
CE462_06065	COG1464	Belongs to the NlpA lipoprotein family
CE462_06070	COG2011	ABC-type metal ion transport system permease component
CE462_06075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CE462_06095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CE462_06095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CE462_06100	COG0802	atpase or kinase
CE462_06110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CE462_06115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CE462_06120	COG1923	regulation of RNA biosynthetic process
CE462_06125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CE462_06130	COG0330	HflC and HflK could
CE462_06135	COG0330	HflC and HflK could
CE462_06140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CE462_06145	COG0142	geranyltranstransferase activity
CE462_06150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CE462_06155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CE462_06160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CE462_06170	COG0318	PFAM AMP-dependent synthetase and ligase
CE462_06190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE462_06205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CE462_06215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CE462_06220	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CE462_06230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CE462_06235	COG3178	'Phosphotransferase
CE462_06240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CE462_06245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE462_06250	COG2252	PERMEase
CE462_06260	COG0488	(ABC) transporter
CE462_06285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE462_06295	COG3721	Heme iron utilization protein
CE462_06300	COG0748	coenzyme F420 binding
CE462_06320	COG4771	TonB-dependent receptor
CE462_06325	COG2814	Major facilitator Superfamily
CE462_06335	COG3655	Transcriptional regulator
CE462_06370	COG3397	chitin binding
CE462_06380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE462_06385	COG1765	OsmC-like protein
CE462_06400	COG3954	Phosphoribulokinase
CE462_06410	COG2076	Multidrug Resistance protein
CE462_06415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CE462_06420	COG0726	polysaccharide deacetylase
CE462_06430	COG0463	Glycosyl transferase, family 2
CE462_06435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE462_06445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE462_06455	COG3089	Belongs to the UPF0270 family
CE462_06460	COG5001	Diguanylate cyclase
CE462_06460	COG2203	Gaf domain
CE462_06460	COG3706	GGDEF domain
CE462_06460	COG4251	negative regulation of phosphorylation
CE462_06465	COG0429	hydrolase of the alpha beta-hydrolase fold
CE462_06470	COG0835	chemotaxis
CE462_06470	COG0784	Response regulator, receiver
CE462_06480	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CE462_06485	COG1047	Peptidyl-prolyl cis-trans
CE462_06490	COG2900	Belongs to the SlyX family
CE462_06500	COG0545	Peptidyl-prolyl cis-trans isomerase
CE462_06505	COG2204	response regulator
CE462_06525	COG0737	Belongs to the 5'-nucleotidase family
CE462_06530	COG2200	EAL domain
CE462_06545	COG0305	Participates in initiation and elongation during chromosome replication
CE462_06550	COG0305	Participates in initiation and elongation during chromosome replication
CE462_06555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE462_06560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE462_06570	COG2199	diguanylate cyclase activity
CE462_06570	COG2200	EAL domain
CE462_06570	COG2203	Gaf domain
CE462_06615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE462_06620	COG2201	protein-glutamate methylesterase activity
CE462_06650	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE462_06655	COG3328	transposase activity
CE462_06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE462_06670	COG2375	cellular response to nickel ion
CE462_06675	COG1538	Outer membrane efflux protein
CE462_06680	COG1136	(ABC) transporter
CE462_06680	COG0577	efflux transmembrane transporter activity
CE462_06685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE462_06695	COG1227	inorganic diphosphatase activity
CE462_06700	COG0497	DNA recombination
CE462_06705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CE462_06710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CE462_06715	COG0443	Heat shock 70 kDa protein
CE462_06720	COG0484	heat shock protein binding
CE462_06750	COG1285	pathogenesis
CE462_06765	COG0640	Transcriptional regulator
CE462_06800	COG0095	Lipoate-protein ligase
CE462_06840	COG0708	Exodeoxyribonuclease III
CE462_06900	COG2814	Major facilitator Superfamily
CE462_06905	COG0109	protoheme IX farnesyltransferase activity
CE462_06915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE462_06920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE462_06955	COG1609	Transcriptional regulator
CE462_06960	COG1263	PTS System
CE462_06960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE462_06980	COG5433	transposase activity
CE462_06995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_07010	COG2207	Transcriptional regulator
CE462_07015	COG0538	isocitrate dehydrogenase activity
CE462_07060	COG0582	viral genome integration into host DNA
CE462_07070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CE462_07075	COG2867	negative regulation of translational initiation
CE462_07085	COG0702	epimerase
CE462_07090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE462_07120	COG4964	Belongs to the GSP D family
CE462_07130	COG2894	cell division
CE462_07170	COG1454	alcohol dehydrogenase
CE462_07185	COG1957	nucleoside hydrolase
CE462_07205	COG0840	transmembrane signaling receptor activity
CE462_07210	COG1280	lysine exporter protein (LysE YggA)
CE462_07220	COG5433	transposase activity
CE462_07225	COG4580	involved in the transport of maltose and maltodextrins
CE462_07235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE462_07235	COG1263	PTS System
CE462_07245	COG2171	N-acyltransferase activity
CE462_07255	COG0024	Methionine aminopeptidase
CE462_07260	COG0052	Belongs to the universal ribosomal protein uS2 family
CE462_07265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CE462_07270	COG0528	UMP kinase activity
CE462_07275	COG0233	cytoplasmic translational termination
CE462_07280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CE462_07285	COG0575	Belongs to the CDS family
CE462_07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CE462_07295	COG0750	zinc metalloprotease
CE462_07310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE462_07315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE462_07320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE462_07325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE462_07330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CE462_07340	COG0825	malonyl-CoA metabolic process
CE462_07345	COG3710	Transcriptional regulator
CE462_07350	COG0531	amino acid
CE462_07355	COG1982	Orn Lys Arg decarboxylase major
CE462_07360	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE462_07375	COG0814	amino acid
CE462_07380	COG0531	amino acid
CE462_07390	COG0488	(ABC) transporter
CE462_07400	COG3590	peptidase
CE462_07405	COG0037	tRNA processing
CE462_07410	COG3706	GGDEF domain
CE462_07445	COG0366	Alpha amylase catalytic
CE462_07455	COG1881	PFAM PEBP family protein
CE462_07465	COG0583	DNA-binding transcription factor activity
CE462_07475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE462_07485	COG0583	DNA-binding transcription factor activity
CE462_07490	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_07495	COG0616	signal peptide processing
CE462_07500	COG3724	N-succinylarginine dihydrolase activity
CE462_07505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE462_07515	COG0840	transmembrane signaling receptor activity
CE462_07525	COG2971	BadF BadG BcrA BcrD
CE462_07535	COG4608	Belongs to the ABC transporter superfamily
CE462_07540	COG0444	Belongs to the ABC transporter superfamily
CE462_07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE462_07595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CE462_07600	COG1289	transmembrane transporter activity
CE462_07605	COG0303	'Molybdopterin
CE462_07610	COG0746	molybdenum cofactor guanylyltransferase activity
CE462_07620	COG4662	Binding-protein-dependent transport system inner membrane component
CE462_07635	COG3852	Histidine kinase
CE462_07645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE462_07660	COG5433	transposase activity
CE462_07690	COG5433	transposase activity
CE462_07720	COG3383	formate dehydrogenase (NAD+) activity
CE462_07725	COG0437	4 iron, 4 sulfur cluster binding
CE462_07740	COG0281	malic enzyme
CE462_07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_07770	COG0281	malic enzyme
CE462_07775	COG3290	protein histidine kinase activity
CE462_07790	COG0667	Aldo Keto reductase
CE462_07800	COG0697	spore germination
CE462_07820	COG2267	carboxylic ester hydrolase activity
CE462_07825	COG1942	4-Oxalocrotonate Tautomerase
CE462_07830	COG1012	belongs to the aldehyde dehydrogenase family
CE462_07835	COG3284	Transcriptional regulator
CE462_07840	COG3706	GGDEF domain
CE462_07845	COG0346	lactoylglutathione lyase activity
CE462_07850	COG0745	RESPONSE REGULATOR receiver
CE462_07855	COG5002	protein histidine kinase activity
CE462_07865	COG4783	chaperone-mediated protein folding
CE462_07875	COG1940	carbohydrate kinase activity
CE462_07880	COG3142	Participates in the control of copper homeostasis
CE462_07885	COG0545	Peptidyl-prolyl cis-trans isomerase
CE462_07890	COG1131	(ABC) transporter
CE462_07910	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CE462_07930	COG0019	diaminopimelate decarboxylase activity
CE462_07935	COG1115	amino acid carrier protein
CE462_07940	COG0095	Lipoate-protein ligase
CE462_07945	COG2233	PERMEase
CE462_07950	COG3706	GGDEF domain
CE462_07950	COG0745	RESPONSE REGULATOR receiver
CE462_07960	COG0534	Mate efflux family protein
CE462_07965	COG2207	Transcriptional regulator
CE462_07970	COG0281	malic enzyme
CE462_07975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CE462_07975	COG2885	chlorophyll binding
CE462_08005	COG0733	neurotransmitter:sodium symporter activity
CE462_08010	COG1752	Esterase of the alpha-beta hydrolase superfamily
CE462_08015	COG3706	GGDEF domain
CE462_08020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE462_08025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE462_08035	COG1032	radical SAM domain protein
CE462_08050	COG5433	transposase activity
CE462_08065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE462_08070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE462_08075	COG0741	lytic transglycosylase activity
CE462_08075	COG0739	heme binding
CE462_08075	COG1196	nuclear chromosome segregation
CE462_08080	COG0366	Alpha amylase catalytic
CE462_08100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE462_08110	COG0788	formyltetrahydrofolate deformylase activity
CE462_08115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE462_08125	COG3118	belongs to the thioredoxin family
CE462_08130	COG2091	lysine biosynthetic process via aminoadipic acid
CE462_08135	COG0791	NLP P60 protein
CE462_08140	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CE462_08155	COG1376	ErfK ybiS ycfS ynhG family protein
CE462_08155	COG1388	LysM domain
CE462_08205	COG1960	acyl-CoA dehydrogenase activity
CE462_08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE462_08220	COG0469	pyruvate kinase activity
CE462_08225	COG1737	Transcriptional regulator
CE462_08250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE462_08270	COG1342	Belongs to the UPF0251 family
CE462_08320	COG1987	bacterial-type flagellum assembly
CE462_08325	COG1684	flagellar biosynthetic protein fliR
CE462_08335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE462_08345	COG0455	bacterial-type flagellum organization
CE462_08360	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CE462_08370	COG0450	alkyl hydroperoxide reductase
CE462_08390	COG0500	methyltransferase
CE462_08395	COG4106	trans-aconitate 2-methyltransferase activity
CE462_08415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CE462_08420	COG0217	transcriptional regulatory protein
CE462_08480	COG1940	carbohydrate kinase activity
CE462_08480	COG1846	Transcriptional regulator
CE462_08485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CE462_08490	COG0363	glucosamine-6-phosphate deaminase activity
CE462_08510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE462_08515	COG0735	belongs to the Fur family
CE462_08525	COG0716	FMN binding
CE462_08540	COG0596	Alpha beta hydrolase
CE462_08545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CE462_08550	COG0033	Phosphoglucomutase
CE462_08560	COG1846	Transcriptional regulator
CE462_08565	COG2951	lytic endotransglycosylase activity
CE462_08570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CE462_08575	COG4136	ATPase activity
CE462_08580	COG4135	transport system, permease component
CE462_08585	COG4134	Bacterial extracellular solute-binding protein
CE462_08595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE462_08605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE462_08610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE462_08625	COG0729	surface antigen
CE462_08630	COG2911	Protein conserved in bacteria
CE462_08645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CE462_08670	COG1607	acyl-coa hydrolase
CE462_08680	COG3021	interspecies interaction between organisms
CE462_08685	COG0741	lytic transglycosylase activity
CE462_08685	COG1388	LysM domain
CE462_08690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE462_08695	COG2226	methyltransferase
CE462_08700	COG0328	RNA-DNA hybrid ribonuclease activity
CE462_08705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE462_08715	COG3437	response regulator, receiver
CE462_08715	COG0784	Response regulator, receiver
CE462_08720	COG1960	acyl-CoA dehydrogenase activity
CE462_08725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE462_08730	COG0121	glutamine amidotransferase
CE462_08750	COG0784	Response regulator, receiver
CE462_08750	COG2205	protein histidine kinase activity
CE462_08760	COG2197	response regulator
CE462_08765	COG3850	Histidine kinase
CE462_08770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CE462_08775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE462_08785	COG0243	molybdopterin cofactor binding
CE462_08790	COG0437	4 iron, 4 sulfur cluster binding
CE462_08795	COG0348	domain, Protein
CE462_08805	COG3005	denitrification pathway
CE462_08810	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE462_08815	COG0315	cyclic pyranopterin monophosphate synthase activity
CE462_08820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CE462_08825	COG0314	molybdopterin synthase activity
CE462_08840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE462_08845	COG0596	Alpha beta hydrolase
CE462_08870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE462_08880	COG0302	gtp cyclohydrolase
CE462_08885	COG0840	transmembrane signaling receptor activity
CE462_08890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CE462_08900	COG0583	DNA-binding transcription factor activity
CE462_08905	COG2353	YceI-like domain
CE462_08930	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE462_08940	COG1166	arginine decarboxylase activity
CE462_08955	COG0346	lactoylglutathione lyase activity
CE462_08965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CE462_08970	COG1187	pseudouridine synthase activity
CE462_08975	COG2807	transmembrane transport
CE462_08985	COG0583	DNA-binding transcription factor activity
CE462_09005	COG2979	Protein of unknown function (DUF533)
CE462_09010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE462_09040	COG2814	Major facilitator Superfamily
CE462_09045	COG0656	L-ascorbic acid biosynthetic process
CE462_09050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CE462_09075	COG0583	DNA-binding transcription factor activity
CE462_09080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CE462_09085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE462_09090	COG2271	Major facilitator Superfamily
CE462_09095	COG1349	DNA-binding transcription factor activity
CE462_09105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE462_09110	COG0584	glycerophosphoryl diester phosphodiesterase
CE462_09115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE462_09120	COG1605	Chorismate mutase
CE462_09120	COG0287	Prephenate dehydrogenase
CE462_09125	COG0583	DNA-binding transcription factor activity
CE462_09130	COG3085	chromosome segregation
CE462_09135	COG4574	serine-type endopeptidase inhibitor activity
CE462_09155	COG1770	oligopeptidase
CE462_09175	COG3083	sulfuric ester hydrolase activity
CE462_09180	COG3082	Protein of unknown function (DUF1414)
CE462_09185	COG3081	Nucleoid-associated protein
CE462_09190	COG2182	Extracellular solute-binding protein
CE462_09195	COG1175	transmembrane transport
CE462_09205	COG3842	ATPase activity
CE462_09220	COG0628	permease
CE462_09225	COG0425	Belongs to the sulfur carrier protein TusA family
CE462_09230	COG4783	chaperone-mediated protein folding
CE462_09240	COG1393	Belongs to the ArsC family
CE462_09255	COG2431	L-lysine efflux transmembrane transporter activity
CE462_09270	COG4215	(ABC) transporter
CE462_09290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE462_09300	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE462_09305	COG2373	Large extracellular alpha-helical protein
CE462_09310	COG4953	penicillin-binding protein 1C
CE462_09320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE462_09320	COG0301	tRNA thio-modification
CE462_09335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE462_09365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE462_09375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CE462_09395	COG0483	inositol monophosphate 1-phosphatase activity
CE462_09405	COG0625	glutathione transferase activity
CE462_09415	COG0601	transmembrane transport
CE462_09420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE462_09425	COG0444	Belongs to the ABC transporter superfamily
CE462_09430	COG2814	Major facilitator Superfamily
CE462_09435	COG0583	DNA-binding transcription factor activity
CE462_09440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE462_09445	COG0243	molybdopterin cofactor binding
CE462_09465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE462_09470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE462_09475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CE462_09480	COG0509	glycine decarboxylation via glycine cleavage system
CE462_09485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE462_09485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE462_09500	COG3634	alkyl hydroperoxide reductase activity
CE462_09505	COG0450	alkyl hydroperoxide reductase
CE462_09510	COG0517	IMP dehydrogenase activity
CE462_09515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CE462_09520	COG0343	queuine tRNA-ribosyltransferase activity
CE462_09525	COG1862	Preprotein translocase
CE462_09530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE462_09535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE462_09540	COG2897	thiosulfate sulfurtransferase activity
CE462_09575	COG1959	2 iron, 2 sulfur cluster binding
CE462_09580	COG1104	cysteine desulfurase activity
CE462_09585	COG0822	iron-sulfur transferase activity
CE462_09595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE462_09600	COG0443	Heat shock 70 kDa protein
CE462_09605	COG0633	Ferredoxin
CE462_09615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE462_09620	COG0105	UTP biosynthetic process
CE462_09625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CE462_09635	COG1426	Protein conserved in bacteria
CE462_09640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CE462_09645	COG0124	histidyl-tRNA synthetase
CE462_09650	COG2976	Protein conserved in bacteria
CE462_09655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE462_09660	COG1160	GTP binding
CE462_09665	COG1645	bacterial-type flagellum-dependent swarming motility
CE462_09670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE462_09675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CE462_09675	COG0047	phosphoribosylformylglycinamidine synthase activity
CE462_09685	COG2354	Protein conserved in bacteria
CE462_09700	COG5433	transposase activity
CE462_09725	COG1242	4 iron, 4 sulfur cluster binding
CE462_09795	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE462_09800	COG1288	antiporter activity
CE462_09805	COG0436	Aminotransferase
CE462_09815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CE462_09820	COG2027	D-alanyl-D-alanine carboxypeptidase
CE462_09825	COG1061	Type III restriction enzyme res subunit
CE462_09830	COG1566	PFAM secretion protein HlyD family protein
CE462_09840	COG1966	Carbon starvation protein
CE462_09845	COG3279	Response regulator of the LytR AlgR family
CE462_09850	COG3275	phosphorelay sensor kinase activity
CE462_09870	COG1454	alcohol dehydrogenase
CE462_09870	COG1012	belongs to the aldehyde dehydrogenase family
CE462_09880	COG2095	MarC family integral membrane protein
CE462_09890	COG0601	transmembrane transport
CE462_09895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE462_09900	COG0444	Belongs to the ABC transporter superfamily
CE462_09915	COG0861	Integral membrane protein TerC family
CE462_09920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE462_09930	COG1301	dicarboxylic acid transport
CE462_09945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE462_09960	COG0537	adenosine 5'-monophosphoramidase activity
CE462_09995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE462_10000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE462_10015	COG5433	transposase activity
CE462_10030	COG1007	ATP synthesis coupled electron transport
CE462_10035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10045	COG0713	ATP synthesis coupled electron transport
CE462_10050	COG0839	Belongs to the complex I subunit 6 family
CE462_10055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CE462_10065	COG1034	ATP synthesis coupled electron transport
CE462_10080	COG0649	NAD binding
CE462_10080	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10095	COG1360	Flagellar Motor Protein
CE462_10115	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CE462_10130	COG4597	amino acid ABC transporter
CE462_10135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_10140	COG0765	amino acid transport
CE462_10145	COG1126	abc transporter atp-binding protein
CE462_10155	COG0724	RNA recognition motif
CE462_10160	COG4989	oxidoreductase activity
CE462_10190	COG0583	DNA-binding transcription factor activity
CE462_10205	COG3300	MHYT domain
CE462_10205	COG5001	Diguanylate cyclase
CE462_10225	COG2814	Major facilitator Superfamily
CE462_10240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE462_10245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CE462_10250	COG0539	negative regulation of cytoplasmic translation
CE462_10255	COG0776	regulation of translation
CE462_10265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CE462_10270	COG0284	orotidine-5'-phosphate decarboxylase activity
CE462_10285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CE462_10290	COG0602	queuosine metabolic process
CE462_10295	COG3530	Putative quorum-sensing-regulated virulence factor
CE462_10300	COG2096	Adenosyltransferase
CE462_10305	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE462_10320	COG1757	Na H antiporter
CE462_10325	COG1435	thymidine kinase activity
CE462_10350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE462_10365	COG5433	transposase activity
CE462_10375	COG0437	4 iron, 4 sulfur cluster binding
CE462_10380	COG5557	Pfam Polysulphide reductase, NrfD
CE462_10385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CE462_10390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CE462_10395	COG1773	rubredoxin
CE462_10405	COG0601	transmembrane transport
CE462_10410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE462_10425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CE462_10430	COG0375	protein maturation
CE462_10435	COG0309	Hydrogenase expression formation protein (HypE)
CE462_10445	COG0298	carbon dioxide binding
CE462_10450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CE462_10460	COG1921	L-seryl-tRNASec selenium transferase activity
CE462_10475	COG3260	NADH ubiquinone oxidoreductase 20
CE462_10480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE462_10485	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CE462_10485	COG3261	NADH dehydrogenase
CE462_10490	COG0650	Formate hydrogenlyase subunit 4
CE462_10495	COG0651	ATP synthesis coupled electron transport
CE462_10500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE462_10555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CE462_10560	COG0326	Molecular chaperone. Has ATPase activity
CE462_10570	COG0563	adenylate kinase activity
CE462_10575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CE462_10580	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CE462_10585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE462_10590	COG0840	transmembrane signaling receptor activity
CE462_10645	COG1021	2,3-dihydroxybenzoate-AMP ligase
CE462_10650	COG3433	isochorismatase activity
CE462_10650	COG1535	isochorismatase
CE462_10655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE462_10660	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_10675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE462_10680	COG2977	Belongs to the P-Pant transferase superfamily
CE462_10685	COG1120	ATPase activity
CE462_10690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE462_10695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE462_10700	COG4771	TonB-dependent receptor
CE462_10720	COG0598	Magnesium transport protein CorA
CE462_10740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CE462_10745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CE462_10750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE462_10765	COG1570	exodeoxyribonuclease VII activity
CE462_10785	COG5433	transposase activity
CE462_10810	COG0516	GMP reductase activity
CE462_10810	COG0517	IMP dehydrogenase activity
CE462_10815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE462_10815	COG0519	Catalyzes the synthesis of GMP from XMP
CE462_10875	COG2062	phosphohistidine phosphatase, SixA
CE462_10885	COG0697	spore germination
CE462_10890	COG4166	transmembrane transport
CE462_10895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CE462_10900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CE462_10910	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE462_10915	COG1136	(ABC) transporter
CE462_10920	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE462_10925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CE462_10940	COG0544	peptidyl-prolyl cis-trans isomerase activity
CE462_10945	COG0740	serine-type endopeptidase activity
CE462_10950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CE462_10955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE462_10960	COG0776	regulation of translation
CE462_10965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE462_10970	COG0488	(ABC) transporter
CE462_10975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE462_10980	COG3162	membrane
CE462_10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE462_10995	COG1024	Enoyl-CoA hydratase
CE462_11000	COG1115	amino acid carrier protein
CE462_11005	COG0456	acetyltransferase
CE462_11015	COG1584	GPR1 FUN34 yaaH family protein
CE462_11045	COG1024	Enoyl-CoA hydratase
CE462_11050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE462_11075	COG1960	acyl-CoA dehydrogenase activity
CE462_11080	COG1024	Enoyl-CoA hydratase
CE462_11085	COG1024	Enoyl-CoA hydratase
CE462_11095	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_11105	COG0730	response to heat
CE462_11140	COG2378	regulation of single-species biofilm formation
CE462_11150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CE462_11150	COG0140	phosphoribosyl-ATP diphosphatase activity
CE462_11155	COG0107	imidazoleglycerol-phosphate synthase activity
CE462_11160	COG0784	Response regulator, receiver
CE462_11160	COG2198	Histidine kinase
CE462_11160	COG2205	protein histidine kinase activity
CE462_11170	COG3437	response regulator, receiver
CE462_11175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CE462_11180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CE462_11185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE462_11185	COG0131	Imidazoleglycerol-phosphate dehydratase
CE462_11190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CE462_11195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CE462_11200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CE462_11210	COG1199	ATP-dependent helicase activity
CE462_11215	COG1214	PFAM Peptidase M22, glycoprotease
CE462_11225	COG2267	carboxylic ester hydrolase activity
CE462_11230	COG0318	PFAM AMP-dependent synthetase and ligase
CE462_11250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE462_11255	COG2832	Protein of unknown function (DUF454)
CE462_11260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CE462_11265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CE462_11270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CE462_11280	COG2197	response regulator
CE462_11290	COG1643	Atp-dependent helicase
CE462_11300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CE462_11305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE462_11310	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CE462_11315	COG0709	Synthesizes selenophosphate from selenide and ATP
CE462_11330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE462_11340	COG1254	Belongs to the acylphosphatase family
CE462_11345	COG0625	glutathione transferase activity
CE462_11350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE462_11350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE462_11355	COG0489	protein tyrosine kinase activity
CE462_11360	COG0572	uridine kinase
CE462_11365	COG0717	Belongs to the dCTP deaminase family
CE462_11370	COG0306	phosphate transporter
CE462_11375	COG1530	ribonuclease E activity
CE462_11385	COG0546	phosphoglycolate phosphatase activity
CE462_11390	COG0424	maF-like protein
CE462_11395	COG1399	metal-binding, possibly nucleic acid-binding protein
CE462_11400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CE462_11405	COG0416	fatty acid biosynthetic process
CE462_11410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE462_11420	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_11425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE462_11430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE462_11435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE462_11440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CE462_11445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CE462_11450	COG0470	DNA polymerase III
CE462_11455	COG0084	hydrolase, TatD family'
CE462_11520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE462_11520	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CE462_11530	COG2995	paraquat-inducible protein a
CE462_11540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CE462_11545	COG0372	Belongs to the citrate synthase family
CE462_11590	COG4221	oxidoreductase activity
CE462_11620	COG3620	sequence-specific DNA binding
CE462_11685	COG5433	transposase activity
CE462_11695	COG1067	ATP-dependent peptidase activity
CE462_11700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE462_11725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE462_11725	COG0116	Belongs to the methyltransferase superfamily
CE462_11740	COG0167	dihydroorotate dehydrogenase activity
CE462_11750	COG5433	transposase activity
CE462_11765	COG0308	aminopeptidase N
CE462_11775	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CE462_11780	COG1956	GAF domain-containing protein
CE462_11790	COG3278	Belongs to the heme-copper respiratory oxidase family
CE462_11805	COG2010	Cytochrome c
CE462_11815	COG2217	Heavy metal translocating P-type atpase
CE462_11830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE462_11835	COG0589	response to stress
CE462_11840	COG0037	tRNA processing
CE462_11860	COG1869	D-ribose catabolic process
CE462_11870	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE462_11875	COG1879	ABC-type sugar transport system periplasmic component
CE462_11880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE462_11885	COG1609	Transcriptional regulator
CE462_11905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CE462_11920	COG2205	protein histidine kinase activity
CE462_11920	COG0784	Response regulator, receiver
CE462_11925	COG0776	regulation of translation
CE462_11930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE462_11930	COG0072	phenylalanine-tRNA ligase activity
CE462_11935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CE462_11940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CE462_11945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CE462_11950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CE462_11955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CE462_11975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE462_11985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE462_11990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE462_11995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE462_12000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CE462_12005	COG3313	Fe-S protein
CE462_12010	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CE462_12010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_12010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_12015	COG1105	Belongs to the carbohydrate kinase PfkB family
CE462_12020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_12020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_12025	COG1609	Transcriptional regulator
CE462_12030	COG0814	amino acid
CE462_12040	COG5654	RES domain protein
CE462_12045	COG0513	Belongs to the DEAD box helicase family
CE462_12055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CE462_12060	COG2890	protein-(glutamine-N5) methyltransferase activity
CE462_12065	COG2840	Smr protein MutS2
CE462_12070	COG3706	GGDEF domain
CE462_12120	COG2824	Alkylphosphonate utilization operon protein PhnA
CE462_12125	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE462_12125	COG1024	Enoyl-CoA hydratase
CE462_12130	COG0183	Belongs to the thiolase family
CE462_12135	COG0714	Associated with various cellular activities
CE462_12175	COG2067	long-chain fatty acid transport protein
CE462_12180	COG2067	long-chain fatty acid transport protein
CE462_12185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CE462_12205	COG3123	guanosine phosphorylase activity
CE462_12210	COG1760	l-serine dehydratase
CE462_12220	COG1760	l-serine dehydratase
CE462_12225	COG2951	lytic endotransglycosylase activity
CE462_12230	COG3100	YcgL domain-containing protein
CE462_12235	COG0850	regulation of cytokinetic process
CE462_12240	COG2894	cell division
CE462_12245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CE462_12255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE462_12300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CE462_12305	COG0697	spore germination
CE462_12310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CE462_12315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE462_12325	COG0307	riboflavin synthase, alpha
CE462_12335	COG0534	Mate efflux family protein
CE462_12370	COG0417	DNA replication proofreading
CE462_12400	COG1560	Kdo2-lipid A biosynthetic process
CE462_12410	COG0583	DNA-binding transcription factor activity
CE462_12415	COG0673	inositol 2-dehydrogenase activity
CE462_12420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CE462_12425	COG0583	DNA-binding transcription factor activity
CE462_12435	COG2723	6-phospho-beta-galactosidase activity
CE462_12440	COG0583	DNA-binding transcription factor activity
CE462_12460	COG1288	antiporter activity
CE462_12470	COG3134	Outer membrane lipoprotein
CE462_12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE462_12510	COG4681	YaeQ
CE462_12555	COG0242	peptide deformylase activity
CE462_12580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE462_12585	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CE462_12590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CE462_12600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE462_12610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CE462_12620	COG0205	6-phosphofructokinase activity
CE462_12655	COG1011	Hydrolase
CE462_12710	COG3593	DNA synthesis involved in DNA repair
CE462_12725	COG0583	DNA-binding transcription factor activity
CE462_12730	COG0730	response to heat
CE462_12745	COG1181	Belongs to the D-alanine--D-alanine ligase family
CE462_12755	COG0386	Belongs to the glutathione peroxidase family
CE462_12760	COG0513	Belongs to the DEAD box helicase family
CE462_12775	COG1742	UPF0060 membrane protein
CE462_12810	COG2329	Antibiotic biosynthesis monooxygenase
CE462_12815	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE462_12835	COG3243	poly(R)-hydroxyalkanoic acid synthase
CE462_12845	COG2501	S4 domain
CE462_12855	COG1132	(ABC) transporter
CE462_12870	COG3118	belongs to the thioredoxin family
CE462_12875	COG0471	metal ion transport
CE462_12880	COG0058	SHG alpha-glucan phosphorylase activity
CE462_12925	COG5433	transposase activity
CE462_12950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE462_12960	COG0814	amino acid
CE462_12965	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CE462_12970	COG0514	ATP-dependent DNA helicase (RecQ)
CE462_12975	COG2766	serine protein kinase
CE462_12985	COG2719	SpoVR family
CE462_12990	COG2186	Transcriptional regulator
CE462_12995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE462_13000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CE462_13005	COG0586	Pfam SNARE associated Golgi protein
CE462_13015	COG0556	nucleotide-excision repair
CE462_13030	COG2985	domain, Protein
CE462_13030	COG0569	domain protein
CE462_13035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE462_13040	COG5433	transposase activity
CE462_13070	COG4565	transcriptional regulatory protein
CE462_13075	COG3290	protein histidine kinase activity
CE462_13080	COG1846	Transcriptional regulator
CE462_13080	COG1940	carbohydrate kinase activity
CE462_13085	COG0840	transmembrane signaling receptor activity
CE462_13090	COG3012	SEC-C Motif Domain Protein
CE462_13095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE462_13100	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CE462_13105	COG0247	lactate metabolic process
CE462_13115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CE462_13120	COG0437	4 iron, 4 sulfur cluster binding
CE462_13125	COG3301	Polysulphide reductase, NrfD
CE462_13140	COG4235	cytochrome complex assembly
CE462_13140	COG3088	subunit of a heme lyase
CE462_13155	COG3033	Beta-eliminating lyase
CE462_13165	COG3046	protein related to deoxyribodipyrimidine photolyase
CE462_13195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CE462_13200	COG0583	DNA-binding transcription factor activity
CE462_13210	COG4774	siderophore transport
CE462_13215	COG3708	Transcriptional regulator
CE462_13215	COG2207	Transcriptional regulator
CE462_13225	COG0583	DNA-binding transcription factor activity
CE462_13230	COG2910	NAD(P)H-binding
CE462_13250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE462_13255	COG1944	ATP diphosphatase activity
CE462_13260	COG2116	formate transmembrane transporter activity
CE462_13265	COG1882	Formate acetyltransferase
CE462_13275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CE462_13280	COG0045	succinate-CoA ligase (ADP-forming) activity
CE462_13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE462_13290	COG0567	Dehydrogenase, E1 component
CE462_13300	COG1053	succinate dehydrogenase
CE462_13305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CE462_13310	COG2009	succinate dehydrogenase
CE462_13330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE462_13335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE462_13335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CE462_13345	COG3069	C4-dicarboxylate transmembrane transporter activity
CE462_13360	COG1451	nucleotide metabolic process
CE462_13375	COG0254	rRNA binding
CE462_13380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE462_13400	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CE462_13405	COG3833	ABC-type maltose transport systems, permease component
CE462_13470	COG4580	involved in the transport of maltose and maltodextrins
CE462_13480	COG1609	Transcriptional regulator
CE462_13485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE462_13505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE462_13515	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE462_13520	COG1129	ABC transporter
CE462_13525	COG1879	ABC-type sugar transport system periplasmic component
CE462_13530	COG1069	ribulokinase activity
CE462_13540	COG2160	L-arabinose isomerase activity
CE462_13545	COG0583	DNA-binding transcription factor activity
CE462_13550	COG0436	Aminotransferase
CE462_13555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE462_13570	COG2925	Exonuclease
CE462_13580	COG3345	alpha-galactosidase
CE462_13590	COG1380	Effector of murein hydrolase LrgA
CE462_13595	COG1346	cytolysis
CE462_13600	COG0295	cytidine deaminase activity
CE462_13605	COG1022	Amp-dependent synthetase and ligase
CE462_13620	COG0861	Integral membrane protein TerC family
CE462_13630	COG2199	diguanylate cyclase activity
CE462_13645	COG2154	pterin-4-alpha-carbinolamine dehydratase
CE462_13655	COG3768	UPF0283 membrane protein
CE462_13660	COG3106	COG3106 Predicted ATPase
CE462_13675	COG1842	Phage shock protein A
CE462_13680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CE462_13690	COG4168	peptide transport system, permease
CE462_13695	COG4171	peptide transport system, permease
CE462_13700	COG4172	Belongs to the ABC transporter superfamily
CE462_13705	COG4172	Belongs to the ABC transporter superfamily
CE462_13715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CE462_13720	COG1286	toxin biosynthetic process
CE462_13725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CE462_13730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CE462_13735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CE462_13740	COG1674	ftsk spoiiie
CE462_13740	COG0531	amino acid
CE462_13760	COG0492	ferredoxin-NADP+ reductase activity
CE462_13770	COG3134	Outer membrane lipoprotein
CE462_13775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CE462_13780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CE462_13785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CE462_13790	COG0542	response to heat
CE462_13795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CE462_13800	COG1278	Cold shock
CE462_13805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CE462_13930	COG0659	secondary active sulfate transmembrane transporter activity
CE462_13980	COG0697	spore germination
CE462_13985	COG4657	Part of a membrane complex involved in electron transport
CE462_13990	COG2878	Part of a membrane complex involved in electron transport
CE462_14000	COG4658	electron transport chain
CE462_14005	COG4659	FMN binding
CE462_14015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CE462_14020	COG0346	lactoylglutathione lyase activity
CE462_14035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE462_14040	COG2056	Na+-H+ antiporter family
CE462_14045	COG3300	MHYT domain
CE462_14045	COG5001	Diguanylate cyclase
CE462_14055	COG0513	Belongs to the DEAD box helicase family
CE462_14060	COG2050	protein possibly involved in aromatic compounds catabolism
CE462_14070	COG0277	FAD linked oxidase domain protein
CE462_14070	COG0247	lactate metabolic process
CE462_14080	COG1253	flavin adenine dinucleotide binding
CE462_14085	COG1902	pentaerythritol trinitrate reductase activity
CE462_14095	COG0647	UMP catabolic process
CE462_14100	COG4651	solute:proton antiporter activity
CE462_14100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE462_14110	COG0367	asparagine synthase
CE462_14135	COG0625	glutathione transferase activity
CE462_14140	COG0625	glutathione transferase activity
CE462_14165	COG0564	pseudouridine synthase activity
CE462_14185	COG0840	transmembrane signaling receptor activity
CE462_14195	COG0670	Belongs to the BI1 family
CE462_14200	COG1289	transmembrane transporter activity
CE462_14205	COG2920	part of a sulfur-relay system
CE462_14210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CE462_14215	COG0285	dihydrofolate synthase activity
CE462_14220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CE462_14225	COG0101	tRNA pseudouridine synthase activity
CE462_14235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE462_14240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE462_14245	COG0671	phosphoesterase, PA-phosphatase related
CE462_14275	COG5433	transposase activity
CE462_14310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE462_14310	COG0574	Belongs to the PEP-utilizing enzyme family
CE462_14315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CE462_14370	COG0672	)-iron permease
CE462_14395	COG2814	Major facilitator Superfamily
CE462_14410	COG1136	(ABC) transporter
CE462_14430	COG1285	pathogenesis
CE462_14480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE462_14485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CE462_14485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE462_14490	COG0527	aspartate kinase activity
CE462_14500	COG1368	sulfuric ester hydrolase activity
CE462_14505	COG1619	proteins homologs of microcin C7 resistance protein MccF
CE462_14515	COG0393	Putative heavy-metal-binding
CE462_14520	COG1252	NADH dehydrogenase
CE462_14560	COG0789	Transcriptional regulator
CE462_14575	COG0493	'glutamate synthase
CE462_14580	COG0070	glutamate synthase
CE462_14580	COG0069	glutamate synthase activity
CE462_14580	COG0067	glutamate synthase
CE462_14585	COG5433	transposase activity
CE462_14625	COG0513	Belongs to the DEAD box helicase family
CE462_14630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE462_14660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE462_14665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CE462_14670	COG0505	Belongs to the CarA family
CE462_14675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CE462_14690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CE462_14695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CE462_14700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE462_14705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CE462_14710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE462_14715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CE462_14725	COG2205	protein histidine kinase activity
CE462_14725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_14765	COG0023	Translation Initiation Factor
CE462_14770	COG2119	membrane
CE462_14800	COG2203	Gaf domain
CE462_14800	COG2199	diguanylate cyclase activity
CE462_14830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE462_14840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE462_14845	COG2261	transglycosylase associated protein
CE462_14885	COG0322	excinuclease ABC activity
CE462_14890	COG2197	response regulator
CE462_14895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CE462_14900	COG2835	tetraacyldisaccharide 4'-kinase activity
CE462_14905	COG1663	tetraacyldisaccharide 4'-kinase activity
CE462_14910	COG1132	(ABC) transporter
CE462_14915	COG0658	competence protein
CE462_14915	COG2333	competence protein COMEC
CE462_14930	COG0433	COG0433 Predicted ATPase
CE462_14935	COG1448	Aminotransferase
CE462_14945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CE462_14950	COG1199	ATP-dependent helicase activity
CE462_14970	COG1785	Belongs to the alkaline phosphatase family
CE462_14990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE462_15005	COG2271	Major facilitator Superfamily
CE462_15010	COG3706	GGDEF domain
CE462_15015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_15020	COG0765	amino acid transport
CE462_15025	COG1126	abc transporter atp-binding protein
CE462_15035	COG0531	amino acid
CE462_15050	COG1253	flavin adenine dinucleotide binding
CE462_15055	COG0704	Plays a role in the regulation of phosphate uptake
CE462_15065	COG0581	inorganic phosphate transmembrane transporter activity
CE462_15070	COG0573	inorganic phosphate transmembrane transporter activity
CE462_15075	COG0590	tRNA wobble adenosine to inosine editing
CE462_15085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CE462_15105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CE462_15110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CE462_15115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CE462_15120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CE462_15125	COG2204	response regulator
CE462_15130	COG3852	Histidine kinase
CE462_15150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CE462_15155	COG0248	Ppx GppA phosphatase
CE462_15160	COG2239	Acts as a magnesium transporter
CE462_15190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE462_15195	COG4786	Flagellar basal body rod
CE462_15200	COG4787	bacterial-type flagellum-dependent cell motility
CE462_15215	COG1558	bacterial-type flagellum-dependent cell motility
CE462_15220	COG1815	bacterial-type flagellum-dependent cell motility
CE462_15225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE462_15230	COG0835	chemotaxis
CE462_15230	COG0784	Response regulator, receiver
CE462_15250	COG0622	Phosphoesterase
CE462_15255	COG4166	transmembrane transport
CE462_15265	COG1187	pseudouridine synthase activity
CE462_15285	COG0697	spore germination
CE462_15325	COG1278	Cold shock
CE462_15380	COG3132	Protein of unknown function, DUF480
CE462_15395	COG5433	transposase activity
CE462_15415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE462_15430	COG5433	transposase activity
CE462_15445	COG3273	potassium ion transport
CE462_15445	COG0471	metal ion transport
CE462_15450	COG5433	transposase activity
CE462_15470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CE462_15475	COG0438	transferase activity, transferring glycosyl groups
CE462_15495	COG1450	Type ii and iii secretion system protein
CE462_15530	COG1459	type II secretion system
CE462_15535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE462_15555	COG1091	dTDP-4-dehydrorhamnose reductase activity
CE462_15565	COG1538	Outer membrane efflux protein
CE462_15580	COG1309	transcriptional regulator
CE462_15595	COG1946	Acyl-CoA thioesterase
CE462_15605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CE462_15615	COG0009	L-threonylcarbamoyladenylate synthase
CE462_15620	COG0613	PHP domain protein
CE462_15625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE462_15630	COG0512	Glutamine amidotransferase of anthranilate synthase
CE462_15630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE462_15635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE462_15640	COG0134	indole-3-glycerol-phosphate synthase activity
CE462_15640	COG0135	phosphoribosylanthranilate isomerase activity
CE462_15645	COG0133	tryptophan synthase activity
CE462_15650	COG0159	tryptophan synthase activity
CE462_15705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_15705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_15705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_15715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE462_15735	COG0482	sulfurtransferase activity
CE462_15740	COG2915	High frequency lysogenization protein hflD homolog
CE462_15745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CE462_15750	COG2850	peptidyl-arginine hydroxylation
CE462_15805	COG0259	pyridoxamine-phosphate oxidase activity
CE462_15820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE462_15820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE462_15825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CE462_15845	COG4235	cytochrome complex assembly
CE462_15845	COG3088	subunit of a heme lyase
CE462_15850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE462_15855	COG1138	Cytochrome C-type biogenesis protein
CE462_15860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CE462_15865	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE462_15870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE462_15875	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE462_15890	COG0835	chemotaxis
CE462_15900	COG1192	Involved in chromosome partitioning
CE462_15905	COG1360	Flagellar Motor Protein
CE462_15910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE462_15915	COG2201	protein-glutamate methylesterase activity
CE462_15920	COG2198	Histidine kinase
CE462_15920	COG0643	Histidine kinase
CE462_15930	COG0583	DNA-binding transcription factor activity
CE462_15940	COG0791	NLP P60 protein
CE462_15955	COG1309	transcriptional regulator
CE462_15995	COG0534	Mate efflux family protein
CE462_16005	COG2841	Protein conserved in bacteria
CE462_16010	COG1013	pyruvate-flavodoxin oxidoreductase activity
CE462_16010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CE462_16010	COG0674	pyruvate-flavodoxin oxidoreductase activity
CE462_16010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CE462_16025	COG3217	Mosc domain protein beta barrel domain protein
CE462_16025	COG3217	Mosc domain protein beta barrel domain protein
CE462_16025	COG0633	Ferredoxin
CE462_16025	COG0633	Ferredoxin
CE462_16035	COG0501	Belongs to the peptidase M48B family
CE462_16040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CE462_16045	COG1073	alpha beta
CE462_16045	COG2226	methyltransferase
CE462_16050	COG0156	8-amino-7-oxononanoate synthase activity
CE462_16055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CE462_16075	COG0017	Asparaginyl-tRNA synthetase
CE462_16095	COG0583	DNA-binding transcription factor activity
CE462_16100	COG1393	Belongs to the ArsC family
CE462_16105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CE462_16110	COG1876	peptidase activity
CE462_16120	COG3263	regulation of cellular component size
CE462_16140	COG5433	transposase activity
CE462_16150	COG0564	pseudouridine synthase activity
CE462_16155	COG3098	single-species biofilm formation
CE462_16180	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CE462_16190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE462_16190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE462_16200	COG3706	GGDEF domain
CE462_16205	COG1611	Belongs to the LOG family
CE462_16210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE462_16215	COG0473	3-isopropylmalate dehydrogenase activity
CE462_16225	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CE462_16230	COG2363	Small membrane protein
CE462_16240	COG0583	DNA-binding transcription factor activity
CE462_16245	COG0840	transmembrane signaling receptor activity
CE462_16250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CE462_16265	COG1477	protein flavinylation
CE462_16270	COG2871	sodium ion transport
CE462_16275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE462_16280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE462_16285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE462_16290	COG1805	sodium ion transport
CE462_16295	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE462_16300	COG0271	Belongs to the BolA IbaG family
CE462_16305	COG2813	Specifically methylates the guanine in position
CE462_16315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE462_16325	COG2211	Major facilitator Superfamily
CE462_16330	COG3248	Nucleoside-binding outer membrane protein
CE462_16335	COG1666	GTP binding
CE462_16340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CE462_16345	COG0693	protein deglycase activity
CE462_16365	COG3459	Glycosyltransferase 36 associated
CE462_16380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE462_16380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE462_16385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE462_16395	COG1151	hydroxylamine reductase activity
CE462_16400	COG0783	Belongs to the Dps family
CE462_16425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE462_16440	COG0300	oxidoreductase activity
CE462_16450	COG0415	Belongs to the DNA photolyase family
CE462_16455	COG0789	Transcriptional regulator
CE462_16460	COG3272	Protein of unknown function (DUF1722)
CE462_16490	COG0077	Prephenate dehydratase
CE462_16490	COG1605	Chorismate mutase
CE462_16515	COG2133	pyrroloquinoline quinone binding
CE462_16540	COG0300	oxidoreductase activity
CE462_16565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CE462_16580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE462_16590	COG3813	Protein conserved in bacteria
CE462_16605	COG1280	lysine exporter protein (LysE YggA)
CE462_16615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE462_16645	COG0835	chemotaxis
CE462_16650	COG0840	transmembrane signaling receptor activity
CE462_16680	COG5433	transposase activity
CE462_16685	COG1917	Cupin 2, conserved barrel domain protein
CE462_16685	COG2169	Transcriptional regulator
CE462_16695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE462_16700	COG1917	Cupin 2, conserved barrel domain protein
CE462_16700	COG1396	sequence-specific DNA binding
CE462_16715	COG0531	amino acid
CE462_16725	COG0531	amino acid
CE462_16730	COG1283	sodium-dependent phosphate transmembrane transporter activity
CE462_16740	COG3384	dioxygenase
CE462_16755	COG0813	purine-nucleoside phosphorylase activity
CE462_16780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE462_16785	COG0083	homoserine kinase activity
CE462_16795	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CE462_16800	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CE462_16815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE462_16825	COG0745	RESPONSE REGULATOR receiver
CE462_16840	COG4988	ABC transporter
CE462_16845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CE462_16865	COG1720	tRNA m6t6A37 methyltransferase activity
CE462_16885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CE462_16890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_16900	COG2190	(PTS) system
CE462_16905	COG3706	GGDEF domain
CE462_16915	COG3038	cytochrome b561
CE462_16925	COG5433	transposase activity
CE462_16935	COG0419	ATPase involved in DNA repair
CE462_16940	COG0420	3'-5' exonuclease activity
CE462_16950	COG2974	May be involved in recombination
CE462_16955	COG0405	Gamma-glutamyltransferase
CE462_16960	COG4651	solute:proton antiporter activity
CE462_16960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE462_16965	COG4651	solute:proton antiporter activity
CE462_16965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE462_16980	COG0469	pyruvate kinase activity
CE462_16985	COG3264	Mechanosensitive ion channel
CE462_16985	COG1196	nuclear chromosome segregation
CE462_16990	COG0582	viral genome integration into host DNA
CE462_17005	COG1846	Transcriptional regulator
CE462_17010	COG1566	PFAM secretion protein HlyD family protein
CE462_17035	COG0602	queuosine metabolic process
CE462_17045	COG1328	CTP reductase activity
CE462_17055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CE462_17060	COG3115	cell septum assembly
CE462_17065	COG1196	nuclear chromosome segregation
CE462_17075	COG2860	membrane
CE462_17085	COG3108	Peptidase M15
CE462_17090	COG2989	Protein conserved in bacteria
CE462_17105	COG0463	Glycosyl transferase, family 2
CE462_17125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE462_17130	COG0739	heme binding
CE462_17135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CE462_17155	COG5433	transposase activity
CE462_17160	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CE462_17170	COG3091	SprT-like family
CE462_17180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CE462_17185	COG0189	ligase activity
CE462_17205	COG1678	Uncharacterized ACR, COG1678
CE462_17210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CE462_17215	COG0583	DNA-binding transcription factor activity
CE462_17230	COG0714	Associated with various cellular activities
CE462_17245	COG1115	amino acid carrier protein
CE462_17250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CE462_17265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CE462_17305	COG2912	Transglutaminase-like superfamily
CE462_17315	COG2890	protein-(glutamine-N5) methyltransferase activity
CE462_17320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CE462_17325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CE462_17330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CE462_17335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CE462_17345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CE462_17350	COG0737	Belongs to the 5'-nucleotidase family
CE462_17355	COG0193	aminoacyl-tRNA hydrolase activity
CE462_17360	COG0012	GTP binding
CE462_17405	COG0471	metal ion transport
CE462_17405	COG0490	domain, Protein
CE462_17415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CE462_17450	COG0443	Heat shock 70 kDa protein
CE462_17465	COG0366	Alpha amylase catalytic
CE462_17480	COG0488	(ABC) transporter
CE462_17500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE462_17510	COG1012	belongs to the aldehyde dehydrogenase family
CE462_17520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CE462_17535	COG0180	Tryptophanyl-tRNA synthetase
CE462_17540	COG0546	phosphoglycolate phosphatase activity
CE462_17545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CE462_17550	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CE462_17560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CE462_17565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CE462_17595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CE462_17600	COG0583	DNA-binding transcription factor activity
CE462_17605	COG0840	transmembrane signaling receptor activity
CE462_17620	COG0583	DNA-binding transcription factor activity
CE462_17635	COG0739	heme binding
CE462_17665	COG0584	glycerophosphoryl diester phosphodiesterase
CE462_17675	COG1053	succinate dehydrogenase
CE462_17680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CE462_17685	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE462_17690	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE462_17710	COG3214	Protein conserved in bacteria
CE462_17745	COG0745	RESPONSE REGULATOR receiver
CE462_17750	COG0642	Histidine kinase
CE462_17760	COG0516	GMP reductase activity
CE462_17770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CE462_17780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE462_17800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE462_17815	COG3706	GGDEF domain
CE462_17825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE462_17830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE462_17835	COG1702	phosphate starvation-inducible protein PhoH
CE462_17840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CE462_17845	COG4535	Mg2 and Co2 transporter CorC
CE462_17850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CE462_17855	COG2888	peptidyl-tyrosine sulfation
CE462_17860	COG0495	leucyl-tRNA aminoacylation
CE462_17880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CE462_17885	COG0799	negative regulation of ribosome biogenesis
CE462_17890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CE462_17895	COG0768	penicillin binding
CE462_17900	COG0772	Belongs to the SEDS family
CE462_17905	COG2951	lytic endotransglycosylase activity
CE462_17910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE462_17915	COG1686	Belongs to the peptidase S11 family
CE462_17920	COG2921	Belongs to the UPF0250 family
CE462_17925	COG0321	lipoyl(octanoyl) transferase activity
CE462_17935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CE462_17950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE462_17955	COG3545	Serine hydrolase
CE462_17970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CE462_17980	COG1970	mechanosensitive ion channel activity
CE462_17985	COG3706	GGDEF domain
CE462_17990	COG4974	Belongs to the 'phage' integrase family
CE462_17995	COG0716	FMN binding
CE462_18005	COG0312	modulator of DNA gyrase
CE462_18050	COG5433	transposase activity
CE462_18065	COG1422	Protein of unknown function (DUF1090)
CE462_18070	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CE462_18075	COG3706	GGDEF domain
CE462_18080	COG2211	Major facilitator Superfamily
CE462_18085	COG1185	polyribonucleotide nucleotidyltransferase activity
CE462_18090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CE462_18095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CE462_18100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CE462_18105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CE462_18110	COG0195	Participates in both transcription termination and antitermination
CE462_18115	COG0779	Required for maturation of 30S ribosomal subunits
CE462_18130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CE462_18135	COG0149	triose-phosphate isomerase activity
CE462_18140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CE462_18145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CE462_18150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CE462_18155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CE462_18160	COG1534	Rna-binding protein
CE462_18170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE462_18185	COG1360	Flagellar Motor Protein
CE462_18190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE462_18195	COG1722	exodeoxyribonuclease VII activity
CE462_18200	COG0142	geranyltranstransferase activity
CE462_18205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CE462_18230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CE462_18235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CE462_18240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE462_18245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CE462_18260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE462_18260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE462_18265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CE462_18280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CE462_18300	COG3381	protein complex oligomerization
CE462_18330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE462_18335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE462_18340	COG0511	ligase activity, forming carbon-carbon bonds
CE462_18345	COG0439	Biotin carboxylase
CE462_18350	COG3924	membrane
CE462_18355	COG4145	pantothenate transmembrane transporter activity
CE462_18360	COG1263	PTS System
CE462_18360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE462_18360	COG2190	(PTS) system
CE462_18365	COG0583	DNA-binding transcription factor activity
CE462_18370	COG0604	alcohol dehydrogenase
CE462_18375	COG2264	protein methyltransferase activity
CE462_18380	COG0531	amino acid
CE462_18385	COG4303	Ethanolamine ammonia lyase large subunit
CE462_18390	COG4302	ethanolamine ammonia-lyase activity
CE462_18410	COG0778	Nitroreductase
CE462_18415	COG1902	pentaerythritol trinitrate reductase activity
CE462_18415	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE462_18420	COG0616	signal peptide processing
CE462_18440	COG3139	Protein of unknown function (DUF1315)
CE462_18445	COG0252	asparaginase activity
CE462_18450	COG0786	glutamate:sodium symporter activity
CE462_18465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CE462_18470	COG0384	phenazine biosynthesis protein PhzF
CE462_18475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE462_18480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE462_18485	COG0175	sulfate reduction
CE462_18490	COG2113	Glycine betaine
CE462_18495	COG4176	ABC-type proline glycine betaine transport system permease component
CE462_18500	COG4175	Glycine betaine
CE462_18510	COG3610	response to peptide
CE462_18515	COG2966	Psort location CytoplasmicMembrane, score
CE462_18530	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE462_18540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE462_18545	COG1028	Short-chain dehydrogenase reductase Sdr
CE462_18555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE462_18580	COG2986	histidine ammonia-lyase
CE462_18595	COG0318	PFAM AMP-dependent synthetase and ligase
CE462_18605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE462_18610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE462_18655	COG1858	cytochrome C peroxidase
CE462_18660	COG5433	transposase activity
CE462_18670	COG2313	pseudouridylate synthase activity
CE462_18675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE462_18675	COG1522	sequence-specific DNA binding
CE462_18705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CE462_18710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CE462_18725	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CE462_18740	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE462_18750	COG4608	Belongs to the ABC transporter superfamily
CE462_18755	COG0444	Belongs to the ABC transporter superfamily
CE462_18760	COG0747	negative chemotaxis
CE462_18765	COG4239	(ABC) transporter, permease
CE462_18785	COG5433	transposase activity
CE462_18800	COG0811	peptide transport
CE462_18805	COG0811	peptide transport
CE462_18810	COG0848	biopolymer transport protein
CE462_18865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE462_18880	COG1278	Cold shock
CE462_18920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CE462_18930	COG0688	phosphatidylethanolamine metabolic process
CE462_18935	COG4628	conserved protein (DUF2132)
CE462_18955	COG3300	MHYT domain
CE462_18955	COG5001	Diguanylate cyclase
CE462_18960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CE462_18965	COG4412	M6 family metalloprotease domain protein
CE462_18965	COG3291	Pkd domain containing protein
CE462_18990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CE462_18995	COG1012	belongs to the aldehyde dehydrogenase family
CE462_19010	COG1132	(ABC) transporter
CE462_19020	COG2897	thiosulfate sulfurtransferase activity
CE462_19025	COG2066	Belongs to the glutaminase family
CE462_19030	COG3171	Protein conserved in bacteria
CE462_19035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CE462_19040	COG4935	Belongs to the peptidase S8 family
CE462_19040	COG2234	aminopeptidase activity
CE462_19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE462_19050	COG2200	EAL domain
CE462_19055	COG1090	epimerase
CE462_19060	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CE462_19065	COG4181	ATPase activity
CE462_19070	COG2755	lipolytic protein G-D-S-L family
CE462_19075	COG0835	chemotaxis
CE462_19075	COG0784	Response regulator, receiver
CE462_19085	COG0569	domain protein
CE462_19085	COG2985	domain, Protein
CE462_19090	COG1272	protein, Hemolysin III
CE462_19095	COG0076	glutamate decarboxylase activity
CE462_19100	COG2917	probably involved in intracellular septation
CE462_19105	COG2350	Protein conserved in bacteria
CE462_19115	COG1555	photosystem II stabilization
CE462_19120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CE462_19125	COG3104	oligopeptide transport
CE462_19130	COG0745	RESPONSE REGULATOR receiver
CE462_19160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE462_19175	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CE462_19180	COG1280	lysine exporter protein (LysE YggA)
CE462_19240	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CE462_19260	COG0513	Belongs to the DEAD box helicase family
CE462_19400	COG0582	viral genome integration into host DNA
CE462_19415	COG0795	lipopolysaccharide-transporting ATPase activity
CE462_19420	COG0795	lipopolysaccharide-transporting ATPase activity
CE462_19425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE462_19430	COG2927	DNA polymerase III (CHI subunit)
CE462_19445	COG0586	Pfam SNARE associated Golgi protein
CE462_19450	COG1686	Belongs to the peptidase S11 family
CE462_19475	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CE462_19480	COG0527	aspartate kinase activity
CE462_19485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE462_19495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CE462_19500	COG1546	Belongs to the CinA family
CE462_19505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CE462_19545	COG1346	cytolysis
CE462_19560	COG0460	homoserine dehydrogenase
CE462_19560	COG0527	aspartate kinase activity
CE462_19565	COG0626	cystathionine gamma-synthase activity
CE462_19580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE462_19585	COG0814	amino acid
CE462_19590	COG1218	3'(2'),5'-bisphosphate nucleotidase
CE462_19595	COG0494	nUDIX hydrolase
CE462_19600	COG1011	Hydrolase
CE462_19605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE462_19620	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CE462_19630	COG3156	type II secretion system protein K
CE462_19635	COG4795	General secretion pathway protein
CE462_19640	COG2165	general secretion pathway protein
CE462_19650	COG2165	general secretion pathway protein
CE462_19655	COG1459	type II secretion system
CE462_19660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE462_19680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CE462_19685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CE462_19705	COG0456	acetyltransferase
CE462_19710	COG3133	Outer membrane lipoprotein
CE462_19725	COG2771	luxR family
CE462_19740	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CE462_19755	COG2213	PTS system mannitol-specific
CE462_19755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_19760	COG0246	Mannitol dehydrogenase
CE462_19765	COG3722	fumarate hydratase activity
CE462_19770	COG3263	regulation of cellular component size
CE462_19775	COG0484	heat shock protein binding
CE462_19795	COG1671	Belongs to the UPF0178 family
CE462_19810	COG1988	membrane-bound metal-dependent
CE462_19815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE462_19825	COG0513	Belongs to the DEAD box helicase family
CE462_19850	COG1575	Belongs to the MenA family. Type 1 subfamily
CE462_19855	COG1169	isochorismate synthase
CE462_19860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CE462_19865	COG0596	Alpha beta hydrolase
CE462_19870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CE462_19880	COG0318	PFAM AMP-dependent synthetase and ligase
CE462_19890	COG5433	transposase activity
CE462_19955	COG5433	transposase activity
CE462_19975	COG2949	membrane
CE462_19990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CE462_19995	COG5380	lipid catabolic process
CE462_20010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CE462_20025	COG2873	o-acetylhomoserine
CE462_20035	COG1979	alcohol dehydrogenase
CE462_20055	COG4221	oxidoreductase activity
CE462_20075	COG1285	pathogenesis
CE462_20095	COG1368	sulfuric ester hydrolase activity
CE462_20100	COG1522	sequence-specific DNA binding
CE462_20110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CE462_20115	COG1418	mRNA catabolic process
CE462_20120	COG1546	Belongs to the CinA family
CE462_20120	COG1058	Belongs to the CinA family
CE462_20130	COG1129	ABC transporter
CE462_20130	COG0842	Transport permease protein
CE462_20155	COG0561	phosphatase activity
CE462_20160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CE462_20170	COG0668	transmembrane transport
CE462_20180	COG1011	Hydrolase
CE462_20195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CE462_20200	COG0019	diaminopimelate decarboxylase activity
CE462_20205	COG1965	Belongs to the frataxin family
CE462_20210	COG0400	carboxylic ester hydrolase activity
CE462_20215	COG3072	Adenylate cyclase
CE462_20220	COG0181	hydroxymethylbilane synthase activity
CE462_20230	COG2959	enzyme of heme biosynthesis
CE462_20245	COG1494	fructose-1,6-bisphosphatase
CE462_20295	COG3932	Exopolysaccharide synthesis, ExoD
CE462_20300	COG0814	amino acid
CE462_20305	COG5433	transposase activity
CE462_20340	COG2022	thiamine diphosphate biosynthetic process
CE462_20350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE462_20355	COG0352	thiamine-phosphate diphosphorylase activity
CE462_20360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CE462_20460	COG3328	transposase activity
CE462_20475	COG2957	Belongs to the agmatine deiminase family
CE462_20485	COG4221	oxidoreductase activity
CE462_20500	COG1024	Enoyl-CoA hydratase
CE462_20510	COG0110	maltose O-acetyltransferase activity
CE462_20520	COG4166	transmembrane transport
CE462_20535	COG1872	DUF167
CE462_20540	COG0762	integral membrane protein
CE462_20545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CE462_20550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CE462_20565	COG3022	response to hydroperoxide
CE462_20570	COG0513	Belongs to the DEAD box helicase family
CE462_20575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CE462_20595	COG0735	belongs to the Fur family
CE462_20600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE462_20615	COG0776	regulation of translation
CE462_20620	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CE462_20645	COG0560	Phosphoserine phosphatase
CE462_20655	COG0813	purine-nucleoside phosphorylase activity
CE462_20660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CE462_20665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CE462_20670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CE462_20685	COG0084	hydrolase, TatD family'
CE462_20705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE462_20710	COG0004	ammonium transporteR
CE462_20745	COG0745	RESPONSE REGULATOR receiver
CE462_20755	COG0189	ligase activity
CE462_20785	COG1639	'signal transduction protein
CE462_20795	COG3700	Belongs to the class B bacterial acid phosphatase family
CE462_20805	COG1366	Belongs to the anti-sigma-factor antagonist family
CE462_20810	COG2172	sigma factor antagonist activity
CE462_20815	COG5002	protein histidine kinase activity
CE462_20815	COG0784	Response regulator, receiver
CE462_20815	COG2205	protein histidine kinase activity
CE462_20820	COG3437	response regulator, receiver
CE462_20830	COG0477	Major facilitator Superfamily
CE462_20845	COG0312	modulator of DNA gyrase
CE462_20850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE462_20860	COG3164	Protein of unknown function
CE462_20865	COG1530	ribonuclease E activity
CE462_20870	COG0424	maF-like protein
CE462_20875	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CE462_20880	COG1792	Involved in formation and maintenance of cell shape
CE462_20885	COG1077	Cell shape determining protein MreB Mrl
CE462_20945	COG2200	EAL domain
CE462_20945	COG2199	diguanylate cyclase activity
CE462_20955	COG0387	Pfam Sodium calcium exchanger
CE462_20960	COG2986	histidine ammonia-lyase
CE462_20965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CE462_20970	COG0010	Belongs to the arginase family
CE462_20975	COG1228	amidohydrolase
CE462_20980	COG2188	Transcriptional regulator
CE462_20985	COG0288	reversible hydration of carbon dioxide
CE462_20995	COG2177	Part of the ABC transporter FtsEX involved in
CE462_21000	COG2884	Cell division ATP-binding protein ftsE
CE462_21005	COG0552	protein localization to endoplasmic reticulum
CE462_21010	COG0742	ribosomal rna small subunit methyltransferase
CE462_21035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE462_21040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE462_21050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE462_21060	COG2095	MarC family integral membrane protein
CE462_21070	COG1301	dicarboxylic acid transport
CE462_21095	COG3714	YhhN family
CE462_21115	COG1770	oligopeptidase
CE462_21130	COG2249	NAD(P)H dehydrogenase (quinone) activity
CE462_21175	COG1987	bacterial-type flagellum assembly
CE462_21200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CE462_21205	COG3107	peptidoglycan biosynthetic process
CE462_21210	COG0792	nuclease activity
CE462_21215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE462_21220	COG2823	Periplasmic or secreted lipoprotein
CE462_21225	COG2969	positive regulation of protein catabolic process
CE462_21230	COG0625	glutathione transferase activity
CE462_21235	COG2857	Cytochrome c1
CE462_21240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CE462_21245	COG0723	plastoquinol--plastocyanin reductase activity
CE462_21250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CE462_21255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CE462_21260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CE462_21270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE462_21275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE462_21310	COG3964	amidohydrolase
CE462_21330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_21335	COG1660	Displays ATPase and GTPase activities
CE462_21340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE462_21350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CE462_21355	COG1137	ATPase activity
CE462_21360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CE462_21365	COG3117	lipopolysaccharide transmembrane transporter activity
CE462_21370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CE462_21375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE462_21375	COG0517	IMP dehydrogenase activity
CE462_21380	COG1127	ABC transporter
CE462_21385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CE462_21390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE462_21395	COG2854	intermembrane phospholipid transfer
CE462_21405	COG5007	Belongs to the BolA IbaG family
CE462_21410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CE462_21415	COG0312	modulator of DNA gyrase
CE462_21420	COG3028	Belongs to the UPF0307 family
CE462_21430	COG2926	Belongs to the UPF0265 family
CE462_21470	COG0203	ribosomal protein L17
CE462_21475	COG0202	RNA polymerase activity
CE462_21480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CE462_21485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CE462_21490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CE462_21495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE462_21500	COG0201	protein transport
CE462_21505	COG0200	Binds to the 23S rRNA
CE462_21510	COG1841	ribosomal large subunit assembly
CE462_21515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CE462_21520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CE462_21525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CE462_21530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CE462_21535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CE462_21540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CE462_21545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CE462_21550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CE462_21555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CE462_21560	COG0255	Belongs to the universal ribosomal protein uL29 family
CE462_21565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CE462_21570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CE462_21575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CE462_21580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CE462_21585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CE462_21590	COG0089	rRNA binding
CE462_21595	COG0088	Forms part of the polypeptide exit tunnel
CE462_21600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CE462_21605	COG0051	transcription antitermination factor activity, RNA binding
CE462_21620	COG0745	RESPONSE REGULATOR receiver
CE462_21625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE462_21630	COG2183	response to ionizing radiation
CE462_21650	COG0596	Alpha beta hydrolase
CE462_21655	COG1040	competence protein
CE462_21660	COG0316	Belongs to the HesB IscA family
CE462_21660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CE462_21665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CE462_21670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CE462_21675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE462_21680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CE462_21685	COG4942	peptidase
CE462_21700	COG0800	Aldolase
CE462_21705	COG0129	dihydroxy-acid dehydratase activity
CE462_21710	COG3265	gluconokinase activity
CE462_21715	COG2610	gluconate transmembrane transporter activity
CE462_21720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE462_21725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CE462_21735	COG0456	acetyltransferase
CE462_21745	COG1490	D-aminoacyl-tRNA deacylase activity
CE462_21750	COG1295	ribonuclease BN
CE462_21760	COG0174	glutamine synthetase
CE462_21770	COG3852	Histidine kinase
CE462_21775	COG2204	response regulator
CE462_21780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CE462_21785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE462_21795	COG3078	GTPase activator activity
CE462_21805	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CE462_21815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CE462_21820	COG0408	coproporphyrinogen oxidase activity
CE462_21825	COG0009	L-threonylcarbamoyladenylate synthase
CE462_21835	COG0551	DNA topoisomerase type I activity
CE462_21840	COG2922	Belongs to the Smg family
CE462_21845	COG0758	DNA mediated transformation
CE462_21850	COG1652	LysM domain
CE462_21855	COG0242	peptide deformylase activity
CE462_21860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CE462_21865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE462_21865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE462_21870	COG0569	domain protein
CE462_21875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE462_21880	COG1322	Protein conserved in bacteria
CE462_21900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE462_21905	COG0686	Belongs to the AlaDH PNT family
CE462_21910	COG0519	Catalyzes the synthesis of GMP from XMP
CE462_21910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE462_21930	COG1012	belongs to the aldehyde dehydrogenase family
CE462_21940	COG2962	Rard protein
CE462_21950	COG1280	lysine exporter protein (LysE YggA)
CE462_21970	COG2146	nitrite reductase [NAD(P)H] activity
CE462_21975	COG2116	formate transmembrane transporter activity
CE462_21980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE462_21980	COG1648	precorrin-2 dehydrogenase activity
CE462_21985	COG2239	Acts as a magnesium transporter
CE462_21995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE462_22000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CE462_22010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CE462_22020	COG0514	ATP-dependent DNA helicase (RecQ)
CE462_22025	COG2050	protein possibly involved in aromatic compounds catabolism
CE462_22045	COG2258	MOSC domain
CE462_22050	COG1177	transmembrane transport
CE462_22055	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE462_22060	COG3842	ATPase activity
CE462_22080	COG0174	glutamine synthetase
CE462_22085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE462_22100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE462_22105	COG0443	Heat shock 70 kDa protein
CE462_22120	COG0366	Alpha amylase catalytic
CE462_22125	COG1086	Polysaccharide biosynthesis protein
CE462_22130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE462_22155	COG0318	PFAM AMP-dependent synthetase and ligase
CE462_22175	COG1083	cytidylyl-transferase
CE462_22185	COG2089	acid synthase
CE462_22210	COG5433	transposase activity
CE462_22220	COG4310	Domain of unknown function (DUF2172)
CE462_22255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE462_22260	COG0745	RESPONSE REGULATOR receiver
CE462_22265	COG2205	protein histidine kinase activity
CE462_22275	COG0281	malic enzyme
CE462_22280	COG0702	epimerase
CE462_22285	COG0254	rRNA binding
CE462_22290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CE462_22300	COG1309	transcriptional regulator
CE462_22320	COG0129	dihydroxy-acid dehydratase activity
CE462_22325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE462_22330	COG3978	acetolactate synthase activity
CE462_22340	COG0606	chelatase, subunit chli
CE462_22350	COG1683	Conserved Protein
CE462_22360	COG1335	isochorismatase
CE462_22370	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CE462_22375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CE462_22380	COG3639	organic phosphonate transmembrane transporter activity
CE462_22385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE462_22390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CE462_22400	COG3084	Protein conserved in bacteria
CE462_22405	COG3706	GGDEF domain
CE462_22405	COG2203	Gaf domain
CE462_22405	COG5001	Diguanylate cyclase
CE462_22405	COG4251	negative regulation of phosphorylation
CE462_22420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CE462_22430	COG1561	YicC-like family, N-terminal region
CE462_22465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE462_22480	COG1063	alcohol dehydrogenase
CE462_22495	COG0210	DNA helicase
CE462_22500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE462_22505	COG2166	iron-sulfur cluster assembly
CE462_22510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CE462_22540	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CE462_22545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE462_22550	COG1739	Uncharacterized protein family UPF0029
CE462_22560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE462_22565	COG1024	Enoyl-CoA hydratase
CE462_22565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE462_22570	COG0183	Belongs to the thiolase family
CE462_22575	COG0745	RESPONSE REGULATOR receiver
CE462_22580	COG2205	protein histidine kinase activity
CE462_22595	COG0425	Belongs to the sulfur carrier protein TusA family
CE462_22600	COG0251	oxidation-reduction process
CE462_22605	COG2885	chlorophyll binding
CE462_22615	COG0752	glycyl-tRNA synthetase alpha subunit
CE462_22620	COG0751	glycine-tRNA ligase activity
CE462_22640	COG2188	Transcriptional regulator
CE462_22645	COG3604	Transcriptional regulator
CE462_22655	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE462_22665	COG0348	domain, Protein
CE462_22670	COG0814	amino acid
CE462_22685	COG2199	diguanylate cyclase activity
CE462_22685	COG2202	Pas domain
CE462_22685	COG2200	EAL domain
CE462_22715	COG3328	transposase activity
CE462_22745	COG1609	Transcriptional regulator
CE462_22755	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE462_22785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE462_22810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CE462_22820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CE462_22825	COG3118	belongs to the thioredoxin family
CE462_22830	COG0513	Belongs to the DEAD box helicase family
CE462_22835	COG0248	Ppx GppA phosphatase
CE462_22845	COG0742	ribosomal rna small subunit methyltransferase
CE462_22850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE462_22870	COG0084	hydrolase, TatD family'
CE462_22875	COG0805	protein transport
CE462_22880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE462_22890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CE462_22895	COG3165	ubiquinone biosynthetic process from chorismate
CE462_22905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CE462_22910	COG0402	S-adenosylhomocysteine deaminase activity
CE462_22950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CE462_22955	COG0848	biopolymer transport protein
CE462_22960	COG0811	peptide transport
CE462_22965	COG0811	peptide transport
CE462_22975	COG2771	luxR family
CE462_22980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CE462_22985	COG1349	DNA-binding transcription factor activity
CE462_22990	COG0745	RESPONSE REGULATOR receiver
CE462_23005	COG4452	Inner membrane protein CreD
CE462_23010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CE462_23015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CE462_23020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CE462_23025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CE462_23030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CE462_23035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CE462_23040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CE462_23050	COG0356	it plays a direct role in the translocation of protons across the membrane
CE462_23055	COG3312	ion transport
CE462_23060	COG1475	DNA binding
CE462_23065	COG1192	Involved in chromosome partitioning
CE462_23070	COG0357	Ribosomal RNA small subunit methyltransferase G
CE462_23075	COG0445	tRNA wobble uridine modification
CE462_23080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE462_23085	COG4774	siderophore transport
CE462_23090	COG4615	Cyclic peptide transporter
CE462_23095	COG1120	ATPase activity
CE462_23100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE462_23110	COG4774	siderophore transport
CE462_23115	COG4607	ABC-type enterochelin transport system periplasmic component
CE462_23120	COG4604	ABC transporter, ATP-binding protein
CE462_23125	COG4605	iron ion homeostasis
CE462_23130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE462_23150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE462_23160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE462_23175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CE462_23180	COG0706	membrane insertase activity
CE462_23185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CE462_23190	COG0594	ribonuclease P activity
CE462_23195	COG0230	Belongs to the bacterial ribosomal protein bL34 family