locus-tag class description ASA_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ASA_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ASA_0003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASA_0004 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASA_0007 ENOG4105D29 Helix-turn-helix type 11 domain protein ASA_0008 ENOG4108ZNX Heat shock protein ASA_0009 ENOG4108ZNX Heat shock protein ASA_0012 ENOG4105JKW Valine--pyruvate aminotransferase ASA_0016 ENOG4105EEX Two component transcriptional regulator (Winged helix family ASA_0017 ENOG4105C08 Histidine kinase ASA_0019 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ASA_0020 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ASA_0021 ENOG4105DC8 reductase ASA_0022 ENOG4105BZU Histidine kinase ASA_0023 ENOG4105BZS acriflavin resistance protein ASA_0024 ENOG410624X efflux transporter, rnd family, mfp subunit ASA_0025 ENOG4105EJ2 Transcriptional regulator ASA_0031 ENOG4105DQF Hydrolase ASA_0032 ENOG4108EUD Lysophospholipase ASA_0033 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase ASA_0034 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASA_0035 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ASA_0036 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ASA_0037 ENOG4105DKP glycosyl transferase, family 9 ASA_0038 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) ASA_0040 ENOG4105EMK carboxylate amino acid amine transporter ASA_0046 ENOG4108M6U Universal stress protein A ASA_0047 ENOG4105RKW reductase (By ASA_0049 ENOG41090A1 ferritin ASA_0050 ENOG4105CBX hi0933 family ASA_0060 ENOG4105D70 Integrase catalytic subunit ASA_0061 ENOG4105F5W AtP-binding protein ASA_0062 ENOG4108GWT fimbrillin MatB ASA_0063 ENOG4108WQH regulatoR ASA_0068 ENOG4108HRK Histidine kinase ASA_0069 ENOG4105DY9 regulatoR ASA_0070 ENOG4105FCD Major Facilitator ASA_0071 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ASA_0072 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ASA_0075 ENOG41063Z6 transcriptional regulator, lysR family ASA_0076 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ASA_0077 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ASA_0084 ENOG4105CUZ uba thif-type nad fad binding protein ASA_0085 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ASA_0086 ENOG4105C9B Cysteine desulfurase ASA_0087 ENOG4105C4R Atp-dependent dna helicase ASA_0090 ENOG4105CPQ Dehydrogenase ASA_0091 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASA_0092 ENOG41062JF Transcriptional regulator ASA_0093 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ASA_0094 ENOG4105CG5 Glycosyl transferase (Group 1 ASA_0097 ENOG4107J0A lipopolysaccharide biosynthetic process ASA_0100 ENOG4105DSJ YicC domain protein ASA_0102 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ASA_0104 ENOG4108Z6Z Transcriptional regulator ASA_0106 ENOG4105PC1 Conserved Protein ASA_0108 ENOG4105E27 serine threonine protein kinase ASA_0109 ENOG4108Z33 Thiol disulfide Interchange Protein ASA_0110 ENOG4105S7S phosphonate abc transporter ASA_0111 ENOG4108VA1 ABC transporter ASA_0112 ENOG4105EHI Phosphonate ABC transporter, periplasmic ASA_0113 ENOG4107RH7 Nicotinate phosphoribosyltransferase ASA_0114 ENOG4108RWI nicotinamidase ASA_0116 ENOG4105EWC Purine nucleoside phosphorylase ASA_0117 ENOG4106HNH Acyl-transferase ASA_0118 ENOG4105C0P Mg chelatase subunit ChlI ASA_0120 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit ASA_0121 ENOG4105CM2 brancheD-chain amino acid aminotransferase ASA_0122 ENOG4105C01 Dihydroxy-acid dehydratase ASA_0123 ENOG4105C7B Threonine dehydratase ASA_0124 ENOG4105UYK outer membrane protein a ASA_0126 ENOG4105XEA Tetr family transcriptional regulator ASA_0128 ENOG4105C25 Primosomal protein n' ASA_0129 ENOG4105VFB Binds the 23S rRNA (By similarity) ASA_0130 ENOG4105CGD Nad-dependent epimerase dehydratase ASA_0131 ENOG4105C6K Malic enzyme ASA_0133 ENOG4105JJR Histidine kinase ASA_0134 ENOG4107EXC regulatoR ASA_0135 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) ASA_0148 ENOG4105D2T synthase ASA_0150 ENOG4105F0R Cytidylyltransferase ASA_0153 ENOG4105CHR reductase ASA_0154 ENOG4105CEY Amp-dependent synthetase and ligase ASA_0157 ENOG4105CND Glycosyl transferase, family 2 ASA_0158 ENOG4105X1N Glycosyl transferase family 8 ASA_0163 ENOG4105C5E polysaccharide biosynthesis protein ASA_0164 ENOG4107R28 alpha amylase, catalytic region ASA_0167 ENOG4105R8A Heat shock protein ASA_0168 ENOG4105C5I Dehydrogenase ASA_0169 ENOG4108RH0 Crea protein ASA_0171 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ASA_0172 ENOG4105CFQ glutamine synthetase ASA_0173 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASA_0175 ENOG4108HM4 ABC transporter ASA_0176 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASA_0177 ENOG4105F38 ABC transporter, permease ASA_0178 ENOG4105D38 putrescine abc transporter ASA_0179 ENOG4108RPX mosc domain containing protein ASA_0182 ENOG4108VUY thioesterase Superfamily protein ASA_0183 ENOG4105C9U ATP-dependent DNA helicase RecQ ASA_0184 ENOG4105N7H Cytochrome ASA_0185 ENOG4105CNG UPF0061 protein ASA_0187 ENOG4105EX9 Membrane ASA_0189 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASA_0191 ENOG4105CJW magnesium transporter ASA_0192 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASA_0193 ENOG4107V9H nitrite transporter ASA_0194 ENOG4105WZK nitrite reductase NADPH small subunit ASA_0196 ENOG4107QZF nitrite reductase NADPH large subunit ASA_0199 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ASA_0200 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ASA_0202 ENOG4105C75 arginyL-tRNA synthetase ASA_0204 ENOG4105K6V RNA polymerase ASA_0206 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ASA_0207 ENOG4105CPC Aldo Keto reductase ASA_0208 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ASA_0209 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ASA_0210 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ASA_0211 ENOG4105CMR udp-glucose 4-epimerase ASA_0212 ENOG41060NJ transcriptional regulator ASA_0217 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0223 ENOG4105C5B carbamate kinase ASA_0224 ENOG4105DBV ornithine carbamoyltransferase ASA_0225 ENOG4105CSX c4-dicarboxylate anaerobic carrier ASA_0226 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ASA_0227 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) ASA_0228 ENOG4105CXT aspartate transcarbamylase ASA_0231 ENOG4105DJ4 phosphatidylserine decarboxylase ASA_0232 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0233 ENOG4105QNF Outer membrane lipoprotein ASA_0234 ENOG4105CF7 AraC family transcriptional regulator ASA_0235 ENOG4108I6A alcohol dehydrogenase ASA_0236 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASA_0237 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASA_0239 ENOG4105WWK YheO domain protein ASA_0240 ENOG4105CEM UPF0597 protein ASA_0242 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ASA_0243 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ASA_0244 ENOG4105C34 Pseudouridine synthase ASA_0245 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ASA_0246 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASA_0247 ENOG4105CU9 asparagine synthetase A ASA_0248 ENOG4108VVK transcriptional Regulator, AsnC ASA_0251 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASA_0252 ENOG410642E Short chain dehydrogenase ASA_0254 ENOG4107WP9 Histidine kinase ASA_0256 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASA_0257 ENOG4108UQ5 membrane protein YcdZ ASA_0258 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) ASA_0259 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) ASA_0262 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASA_0263 ENOG4105IFJ Histidine kinase ASA_0265 ENOG4107QY8 reductase ASA_0266 ENOG4105CUW cytochrome C-TYPE protein ASA_0267 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASA_0269 ENOG4107ZYR domain protein ASA_0270 ENOG4105D4A Cell wall formation (By similarity) ASA_0271 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ASA_0275 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASA_0277 ENOG4105PM1 preprotein translocase subunit SecE ASA_0278 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ASA_0279 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ASA_0280 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ASA_0281 ENOG4108VZM 50s ribosomal protein L10 ASA_0282 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ASA_0283 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASA_0284 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASA_0285 ENOG4105WWK YheO domain protein ASA_0286 ENOG4105KME endoribonuclease L-psp ASA_0288 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ASA_0289 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ASA_0290 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ASA_0291 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ASA_0292 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASA_0293 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASA_0294 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ASA_0299 ENOG41090HJ UPF0265 protein ASA_0301 ENOG4105N42 UPF0307 protein ASA_0302 ENOG4105CMS peptidase U62, modulator of DNA gyrase ASA_0303 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ASA_0304 ENOG4105VFK BolA family ASA_0306 ENOG4105E3I toluene tolerance ASA_0307 ENOG4107PE3 Mammalian cell entry related domain protein ASA_0308 ENOG4105CY3 ABC transporter, permease ASA_0309 ENOG4105DHJ ABC, transporter ASA_0310 ENOG4105C2X Arabinose 5-phosphate isomerase ASA_0311 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ASA_0312 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) ASA_0313 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ASA_0314 ENOG4108IUZ ABC transporter ASA_0315 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASA_0316 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ASA_0317 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ASA_0318 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ASA_0319 ENOG41080Z8 PHOSPHOCARRIER protein ASA_0323 ENOG41069H0 dihydroorotase EC 3.5.2.3 ASA_0329 ENOG4105C0H protease ASA_0330 ENOG4105C0H protease ASA_0332 ENOG4105D6Z AFG1 family ATPase ASA_0333 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ASA_0334 ENOG4108UJD 30S ribosomal protein S9 ASA_0335 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASA_0336 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASA_0337 ENOG4105EIX cytochrome c1 ASA_0338 ENOG4107MKT Stringent starvation protein a ASA_0339 ENOG4105KB2 stringent starvation protein b ASA_0340 ENOG4105W4M Transport-associated protein ASA_0341 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASA_0342 ENOG41082RQ UPF0102 protein ASA_0343 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ASA_0344 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ASA_0347 ENOG4105DD5 Flagellar motor switch protein ASA_0348 ENOG4105CN7 Flagellar biosynthetic protein FliP ASA_0349 ENOG4105VS8 Flagellar biosynthetic protein fliq ASA_0350 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ASA_0351 ENOG4105D00 flagellar biosynthetic protein flhB ASA_0353 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASA_0354 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ASA_0355 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ASA_0356 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASA_0358 ENOG4108JIR Flagellum-specific ATP synthase ASA_0361 ENOG4105M9M anti-sigma28 factor FlgM ASA_0363 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ASA_0364 ENOG4108ZC9 flagellar basal-body rod protein flgc ASA_0366 ENOG4105BZE flagellar hook protein, FlgE ASA_0367 ENOG4105CGA flagellar basal-body rod protein FlgG ASA_0368 ENOG4105CGA flagellar basal-body rod protein FlgG ASA_0369 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASA_0370 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASA_0372 ENOG4105E1Q flagellar hook-associated protein ASA_0379 ENOG410804A Flagellar hook-associated 2 domain-containing protein ASA_0380 ENOG4105MQ3 flagellar protein FliS ASA_0385 ENOG4107RD7 Flagellar Motor Protein, MotA ASA_0386 ENOG4105ER2 Ompa motb domain protein ASA_0387 ENOG4105E9H Lytic Murein transglycosylase ASA_0389 ENOG4108V6E Cell division protein mraZ ASA_0390 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ASA_0391 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ASA_0392 ENOG4105CJN penicillin-binding protein ASA_0393 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ASA_0394 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ASA_0395 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ASA_0396 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ASA_0397 ENOG4105CNI cell division protein FtsW ASA_0398 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ASA_0399 ENOG4105DFU Cell wall formation (By similarity) ASA_0400 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ASA_0401 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ASA_0402 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ASA_0403 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASA_0405 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASA_0407 ENOG4105M6F mutator MutT protein ASA_0408 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ASA_0409 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) ASA_0411 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASA_0413 ENOG4107QHF type ii secretion system protein e ASA_0415 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ASA_0418 ENOG41073TP transcriptional regulator ASA_0419 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ASA_0420 ENOG4107QSN dihydrolipoamide acetyltransferase ASA_0421 ENOG4107QN2 dihydrolipoyl dehydrogenase ASA_0422 ENOG4105BZU Histidine kinase ASA_0424 ENOG4108N3W hemolysin secretion protein ASA_0427 ENOG4107QIJ Aconitate hydratase 2 ASA_0428 ENOG4105BZU Histidine kinase ASA_0429 ENOG4105F6U Short-chain dehydrogenase reductase Sdr ASA_0430 ENOG4105HEI LysR family (Transcriptional regulator ASA_0432 ENOG4105E82 cytochrome subunit of dehydrogenase ASA_0434 ENOG4105CKI cobalamin synthesis protein ASA_0435 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASA_0437 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASA_0438 ENOG4107ZVW dihydroneopterin aldolase ASA_0439 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ASA_0460 ENOG4105DWD nucleoside recognition domain protein ASA_0462 ENOG4107R88 Chemotaxis protein (CheV) ASA_0463 ENOG410904N short-chain dehydrogenase reductase ASA_0464 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ASA_0467 ENOG4108UQY Iron-storage protein ASA_0469 ENOG4108Z5K methylglyoxal synthase ASA_0472 ENOG4105HDK L-asparaginase ASA_0474 ENOG4105DDV Transcriptional regulator (LacI family ASA_0476 ENOG4105DKQ ROK family ASA_0477 ENOG4105VCP PTS System ASA_0478 ENOG4105CS2 ec 3.2.1.21 ASA_0479 ENOG4105CK1 PTS System ASA_0480 ENOG4105VZJ PTS System ASA_0481 ENOG4105CK1 PTS System ASA_0483 ENOG4105D4X repressor ASA_0485 ENOG4105CG3 alpha amylase, catalytic region ASA_0486 ENOG4108UW5 maltose o-acetyltransferase ASA_0488 ENOG4105DFD Na H antiporter ASA_0496 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ASA_0497 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASA_0498 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASA_0499 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASA_0502 ENOG4107VXZ Hydrolase ASA_0503 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ASA_0504 ENOG4105F1S paraquat-inducible protein a ASA_0505 ENOG4105DY2 Paraquat-inducible protein b ASA_0506 ENOG4108Q2G (LipO)protein ASA_0507 ENOG4105UYK outer membrane protein a ASA_0510 ENOG4105H4F exported protein ASA_0512 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ASA_0513 ENOG4105CEN a g-specific adenine glycosylase ASA_0516 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ASA_0517 ENOG4105CJ3 phosphate transporter ASA_0518 ENOG4107IX6 phosphate transport regulator ASA_0521 ENOG4105D1S lipid A biosynthesis ASA_0522 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ASA_0523 ENOG4105DFG type I secretion outer membrane protein ASA_0525 ENOG41087AY ADP-Ribose pyrophosphatase ASA_0526 ENOG4108SX3 cytoplasmic protein ASA_0527 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ASA_0528 ENOG4105IPS esterase ASA_0531 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASA_0532 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASA_0539 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASA_0546 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ASA_0547 ENOG41087YS Phage shock protein A ASA_0550 ENOG41082IR Excinuclease ABC C subunit domain protein ASA_0552 ENOG4105FR1 rard protein ASA_0553 ENOG4108RG0 uracil-dna glycosylase ASA_0555 ENOG4105ETT transcriptional Regulator, LysR family ASA_0556 ENOG4105FAV ABC, transporter ASA_0557 ENOG4105FDK ABC transporter ASA_0558 ENOG4105NXV High-affinity zinc uptake system protein ASA_0562 ENOG4105DR5 peptidase ASA_0564 ENOG4105R2J Conserved Protein ASA_0568 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ASA_0572 ENOG4105D6J arsenicaL-resistance protein ASA_0573 ENOG4105K89 arsenate reductase ASA_0574 ENOG4105H3G oxidoreductase ASA_0576 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ASA_0578 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ASA_0579 ENOG4105CAS nag kinase ASA_0581 ENOG4105CDH Citrulline--aspartate ligase ASA_0582 ENOG4105CH7 arginosuccinase ASA_0583 ENOG4107NQ8 LysR family Transcriptional regulator ASA_0585 ENOG41090U3 tautomerase ASA_0591 ENOG4108UW5 maltose o-acetyltransferase ASA_0592 ENOG4107PU6 Membrane ASA_0593 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASA_0595 ENOG4108I5D sulfate abc transporter ASA_0596 ENOG4105ECW sulfate abc transporter ASA_0597 ENOG4108IJ6 ABC transporter ASA_0598 ENOG4107R11 Transcriptional regulator ASA_0599 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ASA_0600 ENOG4105E5Q amino acid AbC transporter ASA_0602 ENOG4105CDA abc transporter atp-binding protein ASA_0603 ENOG4105CT1 (ABC) transporter ASA_0604 ENOG4108M1A Chitin-binding protein ASA_0605 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0614 ENOG4105CND Glycosyl transferase, family 2 ASA_0620 ENOG4105G0K glycine radical enzyme YjjI family ASA_0621 ENOG41076CZ activating enzyme ASA_0624 ENOG4105CGF Aromatic amino acid aminotransferase ASA_0630 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ASA_0632 ENOG4105C1J atp-dependent rna helicase ASA_0636 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASA_0639 ENOG4105XTV UPF0231 protein ASA_0640 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ASA_0641 ENOG4107QQ0 gntp family ASA_0641 ENOG4107QQ0 gntp family ASA_0642 ENOG4105BZW Glycerate kinase ASA_0645 ENOG4105JQN Transcriptional regulator ASA_0646 ENOG4105D9N nucleoside ASA_0647 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASA_0648 ENOG4108YZN class I peptide chain release factor ASA_0649 ENOG4108YZA Nitrogen regulatory protein pii ASA_0652 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASA_0653 ENOG4105EZR dyp-type peroxidase family protein ASA_0654 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ASA_0655 ENOG4105E5Z arginine transporter ATP-binding subunit ASA_0656 ENOG4106PMH Extracellular solute-binding protein family 3 ASA_0657 ENOG4105GBT ABC transporter ASA_0658 ENOG4105DMR ABC, transporter ASA_0659 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ASA_0660 ENOG4108UV7 flagellar protein motX ASA_0661 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASA_0662 ENOG4105KPV Transcriptional regulator ASA_0663 ENOG4108JU6 CBS domain protein ASA_0664 ENOG4106KVJ cytochrome C assembly protein ASA_0665 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ASA_0666 ENOG4105K5M 30s ribosomal protein S16 ASA_0667 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ASA_0668 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ASA_0669 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ASA_0671 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) ASA_0673 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASA_0674 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ASA_0675 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ASA_0676 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ASA_0677 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASA_0679 ENOG41063Z6 transcriptional regulator, lysR family ASA_0680 ENOG41080HT Transcriptional regulator, arsr family ASA_0681 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ASA_0682 ENOG4105CJR Integral membrane protein (MviN ASA_0683 ENOG4105DTN riboflavin biosynthesis protein ribF ASA_0684 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ASA_0685 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ASA_0686 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ASA_0687 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ASA_0688 ENOG4106855 Competence protein ASA_0694 ENOG4105C4K Nad synthetase ASA_0695 ENOG4108YZA Nitrogen regulatory protein pii ASA_0697 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ASA_0698 ENOG4106TD9 Diguanylate cyclase ASA_0699 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ASA_0700 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASA_0706 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ASA_0707 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ASA_0708 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ASA_0709 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ASA_0710 ENOG4105DP0 ferredoxin-NADP reductase ASA_0714 ENOG4105DQ4 alcohol dehydrogenase ASA_0715 ENOG4105W39 Membrane ASA_0717 ENOG4105D9M gamma-glutamylcysteine synthetase ASA_0719 ENOG4108IQE Amp-dependent synthetase and ligase ASA_0721 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASA_0723 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) ASA_0724 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ASA_0726 ENOG4105EW9 transcriptional regulator AsnC family ASA_0728 ENOG4105BZU Histidine kinase ASA_0729 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ASA_0731 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASA_0733 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASA_0734 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0735 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ASA_0736 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ASA_0737 ENOG4105C4M (Ubiquinol oxidase) subunit I ASA_0738 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASA_0740 ENOG4105KJB cyd operon protein YbgE ASA_0741 ENOG4107YD3 Thioesterase ASA_0742 ENOG4105E02 MotA TolQ exbB proton channel ASA_0743 ENOG4105M8F Biopolymer transport protein exbD tolR ASA_0745 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ASA_0746 ENOG4105KCK Peptidoglycan-associated lipoprotein ASA_0747 ENOG4105UFD tol-pal system protein YbgF ASA_0756 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0757 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ASA_0758 ENOG4105DSB aldose 1-epimerase ASA_0759 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASA_0760 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ASA_0761 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ASA_0763 ENOG4105E0X reductase ASA_0765 ENOG4105EYW Ion transport protein ASA_0766 ENOG4106MWK domain protein ASA_0767 ENOG4105C26 Dehydrogenase ASA_0768 ENOG4105E09 nadh pyrophosphatase ASA_0769 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ASA_0770 ENOG4105F0N pyrophosphate phospho-hydrolase ASA_0771 ENOG4105DFU Cell wall formation (By similarity) ASA_0772 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ASA_0773 ENOG410630P Transcriptional regulator ASA_0774 ENOG4108UGV hypoxanthine phosphoribosyltransferase ASA_0775 ENOG4105DA5 (ABC) transporter ASA_0776 ENOG4105E3A (ABC) transporter ASA_0778 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ASA_0779 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ASA_0780 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASA_0781 ENOG4105DJ0 Poly(A) Polymerase ASA_0782 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ASA_0783 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ASA_0784 ENOG4105PW4 Sugar fermentation stimulation protein homolog ASA_0786 ENOG4105CQ7 ATP-dependent helicase ASA_0787 ENOG4105BZ4 penicillin-binding protein ASA_0788 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ASA_0789 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) ASA_0790 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) ASA_0791 ENOG4105CWB LysR family transcriptional Regulator ASA_0792 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_0794 ENOG41076MN Phosphoesterase, PA-phosphatase related ASA_0797 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ASA_0798 ENOG4105CMQ Chloride channel ASA_0800 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ASA_0806 ENOG410829K Lysine exporter protein (Lyse ygga) ASA_0807 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ASA_0808 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASA_0810 ENOG4107V40 secretion protein, HlyD family ASA_0816 ENOG4105I93 response regulator ASA_0817 ENOG4105DUX Transporter ASA_0818 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ASA_0819 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ASA_0820 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ASA_0821 ENOG4105K9H YciI-like protein ASA_0822 ENOG4107835 probably involved in intracellular septation (By similarity) ASA_0823 ENOG4105DY8 decarboxylase ASA_0824 ENOG4108UT2 hemolysin iii ASA_0825 ENOG4105D0C transport protein ASA_0827 ENOG4107R88 Chemotaxis protein (CheV) ASA_0828 ENOG4108UJV acyl-CoA thioesterase i ASA_0829 ENOG4108I0Y (ABC) transporter ASA_0830 ENOG4105CV6 ABC transporter, permease ASA_0831 ENOG4105ECP epimerase ASA_0832 ENOG4105BZU Histidine kinase ASA_0835 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ASA_0836 ENOG41090ED Protein with unknown function (DUF469) ASA_0837 ENOG4105CSV Glutaminase ASA_0838 ENOG4107RM6 sulfurtransferase ASA_0839 ENOG4105SUV lipoprotein YgdR ASA_0840 ENOG4105BZ1 (ABC) transporter ASA_0843 ENOG4105C26 Dehydrogenase ASA_0849 ENOG4107G87 m6 family metalloprotease domain protein ASA_0850 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) ASA_0851 ENOG4105BZU Histidine kinase ASA_0855 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASA_0856 ENOG4105DJ4 phosphatidylserine decarboxylase ASA_0858 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ASA_0864 ENOG4105VEQ Cold shock protein ASA_0866 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0867 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ASA_0876 ENOG4109015 Biopolymer transport protein exbD tolR ASA_0882 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ASA_0883 ENOG4107QRA Extracellular solute-binding protein, family 5 ASA_0885 ENOG4108JQ7 (ABC) transporter ASA_0887 ENOG4105CIN aminoacyl-histidine dipeptidase ASA_0890 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ASA_0891 ENOG4105V1F Fermentation respiration switch protein ASA_0893 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ASA_0894 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ASA_0900 ENOG4105DD7 kinase (PfkB family ASA_0901 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) ASA_0903 ENOG4105CA0 peroxidase ASA_0910 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASA_0913 ENOG4108KW7 amp-dependent synthetase and ligase ASA_0916 ENOG4105C84 Histidine ammonia-lyase ASA_0922 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASA_0924 ENOG4105C2D reductase ASA_0925 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASA_0927 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASA_0929 ENOG4105DWK Membrane ASA_0931 ENOG4107XM3 UPF0442 protein ASA_0933 ENOG4108IJ7 Glycine betaine ASA_0934 ENOG4108HQS Glycine betaine ASA_0935 ENOG4105GIJ Glycine betaine ASA_0936 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ASA_0939 ENOG4107TIF Phenazine biosynthesis protein, PhzF family ASA_0940 ENOG4105CRK lysyL-tRNA synthetase ASA_0942 ENOG4105C8Q Methyl-accepting chemotaxis ASA_0943 ENOG4105D6U Sodium Glutamate Symporter ASA_0944 ENOG4105HDK L-asparaginase ASA_0945 ENOG4105VUT cytoplasmic protein ASA_0949 ENOG4105D07 Signal peptide peptidase, SppA ASA_0950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASA_0951 ENOG41069NU Nitroreductase ASA_0955 ENOG4107FQ9 ethanolamine ammonia-lyase ASA_0956 ENOG4105CPD ethanolamine ammonia-lyase ASA_0958 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ASA_0959 ENOG4105CIS alcohol dehydrogenase ASA_0960 ENOG4105HEI LysR family (Transcriptional regulator ASA_0961 ENOG4105CI1 PTS System ASA_0962 ENOG4108IA2 Sodium pantothenate symporter ASA_0963 ENOG4105RG0 Membrane ASA_0964 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASA_0965 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ASA_0966 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ASA_0967 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASA_0969 ENOG4105BZU Histidine kinase ASA_0973 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASA_0975 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASA_0978 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ASA_0979 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ASA_0982 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASA_0983 ENOG4107YIM Involved in the transcription termination process (By similarity) ASA_0984 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ASA_0985 ENOG4108ZAI phosphatidylglycerophosphatase a ASA_0986 ENOG4108JQ6 ABC transporter ASA_0988 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASA_0990 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ASA_0991 ENOG4105CTB Polyprenyl synthetase ASA_0992 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASA_0993 ENOG4105E14 MotA TolQ exbB proton channel ASA_0997 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ASA_0999 ENOG4105HBR Rna-binding protein ASA_1000 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ASA_1001 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASA_1002 ENOG4105EEI dihydropteroate synthase ASA_1003 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ASA_1004 ENOG4105CP7 Triose-phosphate isomerase ASA_1008 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ASA_1009 ENOG4105CHV Transcription elongation factor NusA ASA_1010 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ASA_1011 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ASA_1012 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ASA_1013 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ASA_1014 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ASA_1016 ENOG4105BZU Histidine kinase ASA_1017 ENOG41090EX DsrE family ASA_1018 ENOG4105WAY exported protein ASA_1020 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) ASA_1027 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASA_1030 ENOG4105D1U peptidase U62 modulator of DNA gyrase ASA_1031 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ASA_1032 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASA_1033 ENOG4105BZU Histidine kinase ASA_1034 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ASA_1036 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ASA_1039 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_1040 ENOG4105MJ9 esterase ASA_1047 ENOG4105D70 Integrase catalytic subunit ASA_1048 ENOG4105F5W AtP-binding protein ASA_1051 ENOG4108ZXE ASA_1054 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ASA_1056 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ASA_1057 ENOG4108Z43 UPF0250 protein ASA_1058 ENOG4105DZ1 carboxypeptidase ASA_1059 ENOG4105K6T rare lipoprotein A ASA_1061 ENOG4105CNI cell division protein FtsW ASA_1062 ENOG4105CJN penicillin-binding protein ASA_1063 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ASA_1064 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ASA_1065 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ASA_1068 ENOG4105C8T Leucyl-tRNA synthetase ASA_1069 ENOG4107PAI alpha helical protein ASA_1070 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ASA_1071 ENOG4108JU5 Magnesium and cobalt efflux protein ASA_1072 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ASA_1073 ENOG4105C9A Phoh family ASA_1074 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ASA_1075 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASA_1076 ENOG4105VEQ Cold shock protein ASA_1077 ENOG4105BZU Histidine kinase ASA_1080 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ASA_1084 ENOG4105C5I Dehydrogenase ASA_1086 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASA_1088 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASA_1090 ENOG4105DHQ Histidine kinase ASA_1091 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASA_1098 ENOG4105T0Z Conserved Protein ASA_1102 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASA_1103 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASA_1104 ENOG4105E33 succinate dehydrogenase ASA_1106 ENOG4105C8Q Methyl-accepting chemotaxis ASA_1107 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ASA_1108 ENOG4105EGS Mechanosensitive ion channel ASA_1111 ENOG4105DR5 peptidase ASA_1114 ENOG4105EJC lysr family transcriptional regulator ASA_1118 ENOG4105C5Q Transcriptional regulator ASA_1119 ENOG4108JQC penicillin-binding protein 1A ASA_1124 ENOG4105E4G Type IV pilus ASA_1125 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASA_1126 ENOG4105D49 3-dehydroquinate synthase ASA_1128 ENOG4105DFE Dna adenine methylase ASA_1129 ENOG4105DJV ribulose-phosphate 3-epimerase ASA_1130 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASA_1131 ENOG4105C31 Tryptophanyl-tRNA synthetase ASA_1133 ENOG4105DDQ anthranilate synthase ASA_1134 ENOG4105C8Y Acetylornithine aminotransferase ASA_1136 ENOG4105C26 Dehydrogenase ASA_1138 ENOG4107VXZ Hydrolase ASA_1140 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ASA_1141 ENOG4107QF7 multi-drug ASA_1142 ENOG4105C5H ABC transporter ASA_1144 ENOG4105CG3 alpha amylase, catalytic region ASA_1146 ENOG4105F7F Chaperone ASA_1150 ENOG41060QA UPF0267 protein ASA_1152 ENOG4108I5U Uridine phosphorylase ASA_1153 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASA_1154 ENOG4107QWE )-transporter ASA_1167 ENOG4105C3G gtp-binding protein ASA_1168 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ASA_1169 ENOG4105CGH 5'-nucleotidase ASA_1170 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ASA_1172 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ASA_1173 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ASA_1174 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ASA_1175 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ASA_1176 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASA_1179 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ASA_1180 ENOG4105CK2 sodium dicarboxylate symporter ASA_1181 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ASA_1183 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ASA_1186 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ASA_1187 ENOG4105BZG amino acid carrier protein ASA_1188 ENOG4105F8C transglutaminase domain-containing protein ASA_1190 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASA_1193 ENOG4105G2Y Transcriptional regulator ASA_1194 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ASA_1195 ENOG4108UJU UPF0301 protein ASA_1197 ENOG4105D7Z glutathione synthase ASA_1200 ENOG4105GPY SprT protein ASA_1201 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ASA_1202 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASA_1204 ENOG4105KME endoribonuclease L-psp ASA_1205 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ASA_1206 ENOG4105DR5 peptidase ASA_1207 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASA_1213 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ASA_1214 ENOG4105EAQ (twin-arginine translocation) pathway signal ASA_1216 ENOG4105EN6 Membrane ASA_1217 ENOG4105EXN Sulfate transport protein CysZ ASA_1218 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ASA_1220 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ASA_1222 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ASA_1224 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ASA_1229 ENOG4105J12 Multidrug resistance protein mdtN ASA_1230 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) ASA_1233 ENOG4107R1I NAD-dependent malic enzyme ASA_1234 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASA_1235 ENOG4106YYS transcriptional regulatory protein ASA_1238 ENOG4105BZU Histidine kinase ASA_1239 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASA_1240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASA_1241 ENOG4105BZU Histidine kinase ASA_1243 ENOG4105ERG peptidase m48, ste24p ASA_1245 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) ASA_1246 ENOG4106N3A copper homeostasis protein cutc ASA_1247 ENOG4108V1T peptidylprolyl cis-trans isomerase ASA_1248 ENOG4105CJ1 ABC, transporter ASA_1252 ENOG4105PTV Nudix Hydrolase ASA_1257 ENOG4105BZG amino acid carrier protein ASA_1258 ENOG4108KMH lipoate-protein ligase a ASA_1259 ENOG4105C2W permease ASA_1260 ENOG4105BZU Histidine kinase ASA_1261 ENOG4105RKX Protein of unknown function (DUF2498) ASA_1262 ENOG4105UQX Mate efflux family protein ASA_1263 ENOG41075H3 AraC family transcriptional regulator ASA_1264 ENOG4107R1I NAD-dependent malic enzyme ASA_1265 ENOG4105UYK outer membrane protein a ASA_1266 ENOG4105UYK outer membrane protein a ASA_1267 ENOG4105UYK outer membrane protein a ASA_1270 ENOG4105C8J )-transporter ASA_1271 ENOG4105D78 K07001 NTE family protein ASA_1272 ENOG4105BZU Histidine kinase ASA_1273 ENOG4105ENT Efflux transporter rnd family, mfp subunit ASA_1274 ENOG4105BZS acriflavin resistance protein ASA_1276 ENOG4105CCT upf0313 protein ASA_1282 ENOG4105EP9 oxidoreductase ASA_1283 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ASA_1284 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ASA_1285 ENOG4105E4C Lytic transglycosylase catalytic ASA_1290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ASA_1292 ENOG4105CIY formyltetrahydrofolate deformylase ASA_1293 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASA_1295 ENOG4107QR8 Thioredoxin ASA_1296 ENOG4107YAK holo-(acyl carrier protein) synthase 2 ASA_1297 ENOG4107TT5 NLP P60 protein ASA_1298 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) ASA_1301 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASA_1303 ENOG4105JPW Domain of unknown function (DUF1837) ASA_1309 ENOG4105D70 Integrase catalytic subunit ASA_1310 ENOG4105F5W AtP-binding protein ASA_1311 ENOG4105CNA YD repeat protein ASA_1316 ENOG4107SSZ Phosphatase ASA_1318 ENOG4107QPN acyl-Coa dehydrogenase ASA_1319 ENOG4105BZS acriflavin resistance protein ASA_1321 ENOG4105CA9 Pyruvate kinase ASA_1322 ENOG4106KNT transcriptional regulator ASA_1324 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASA_1325 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASA_1327 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ASA_1328 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_1331 ENOG4105VYW UPF0251 protein ASA_1334 ENOG4105EFZ amidohydrolase ASA_1336 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ASA_1337 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ASA_1338 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASA_1340 ENOG4108JIR Flagellum-specific ATP synthase ASA_1344 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASA_1345 ENOG4105DD5 Flagellar motor switch protein ASA_1346 ENOG4105VTB flagellar biosynthesis protein fliO ASA_1347 ENOG4105CN7 Flagellar biosynthetic protein FliP ASA_1348 ENOG4105VS8 Flagellar biosynthetic protein fliq ASA_1349 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ASA_1350 ENOG4105D00 flagellar biosynthetic protein flhB ASA_1351 ENOG4105D7B Flagellar biosynthesis protein flha ASA_1352 ENOG4105FZW flagellar biosynthesis regulator FlhF ASA_1353 ENOG4107R21 site-determining protein ASA_1354 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASA_1355 ENOG4108VYJ response regulator receiver protein ASA_1356 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ASA_1357 ENOG4105CBS Chea signal transduction histidine kinase ASA_1358 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASA_1360 ENOG4108SEK ompa motb domain protein ASA_1361 ENOG4107QJE Chromosome Partitioning Protein ASA_1363 ENOG4108V3W Chemotaxis protein, CheW ASA_1366 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ASA_1367 ENOG41060IM Heme exporter protein ASA_1368 ENOG4105X3C heme exporter protein ASA_1369 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ASA_1370 ENOG4105DA4 cytochrome c-type biogenesis protein ASA_1371 ENOG4107QX9 Thiol disulfide interChange protein ASA_1372 ENOG4105KWW Biogenesis protein ASA_1374 ENOG410903C (LipO)protein ASA_1375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASA_1376 ENOG4105M2J Glutaredoxin ASA_1380 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ASA_1381 ENOG4108TGY Glutathione S-transferase ASA_1383 ENOG4108YYD acetyltransferase ASA_1388 ENOG4105EZE Cupin 4 family protein ASA_1389 ENOG4107QTF adenylosuccinate lyase ASA_1390 ENOG41075W9 High frequency lysogenization protein HflD homolog ASA_1391 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ASA_1393 ENOG4108R99 pseudouridine synthase ASA_1395 ENOG4108YRF PTS System ASA_1396 ENOG4105CXY transporter ASA_1397 ENOG4105DM4 PTS System ASA_1402 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ASA_1403 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ASA_1404 ENOG4105DK0 Indole-3-glycerol phosphate synthase ASA_1405 ENOG4108I0Q anthranilate phosphoribosyltransferase ASA_1406 ENOG4108EFP Anthranilate synthase component II ASA_1407 ENOG4105CRQ synthase (Component I) ASA_1409 ENOG4105DB7 PHP domain protein ASA_1410 ENOG4107RTD sua5 ycio yrdc ywlc family protein ASA_1412 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ASA_1413 ENOG4105FE9 pseudouridine synthase ASA_1414 ENOG4105C29 acyl-CoA thioesterase ASA_1417 ENOG4108IG5 Transcriptional regulator ASA_1418 ENOG4105C1P efflux transporter, rnd family, mfp subunit ASA_1419 ENOG4105BZS acriflavin resistance protein ASA_1420 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ASA_1422 ENOG4105C1B dTDP-glucose 4-6-dehydratase ASA_1423 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase ASA_1425 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ASA_1427 ENOG4107QHF type ii secretion system protein e ASA_1428 ENOG4105D7Q type ii secretion system ASA_1429 ENOG4108VAU general secretion pathway protein G ASA_1437 ENOG4105GVR general secretion pathway protein D ASA_1439 ENOG4105EY8 ABC transporter ASA_1441 ENOG4107EF8 Glycosyl transferase (Group 1 ASA_1449 ENOG4105ESV Glycosyl transferase, family 4 ASA_1456 ENOG4105CG5 Glycosyl transferase (Group 1 ASA_1460 ENOG4108YXG UPF0502 protein ASA_1463 ENOG4105D70 Integrase catalytic subunit ASA_1464 ENOG4105F5W AtP-binding protein ASA_1467 ENOG4107RUY (E1 component), alpha subunit ASA_1468 ENOG4105CPP Dehydrogenase, E1 component ASA_1471 ENOG4105VEQ Cold shock protein ASA_1479 ENOG4105CPI Metal Dependent Phosphohydrolase ASA_1480 ENOG4105I08 Pseudouridine synthase ASA_1482 ENOG4108J59 Extracellular solute-binding protein, family 5 ASA_1483 ENOG4108RE9 Phosphodiesterase ASA_1487 ENOG4107R88 Chemotaxis protein (CheV) ASA_1488 ENOG4105BZU Histidine kinase ASA_1489 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ASA_1490 ENOG4108ZC9 flagellar basal-body rod protein flgc ASA_1492 ENOG4105BZE flagellar hook protein, FlgE ASA_1493 ENOG4108KPB Flagellar basal-body rod protein FlgF ASA_1494 ENOG4105CGA flagellar basal-body rod protein FlgG ASA_1495 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASA_1496 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASA_1497 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ASA_1500 ENOG4105CJW magnesium transporter ASA_1501 ENOG4105C9X ppx gppa phosphatase ASA_1502 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ASA_1506 ENOG4105BZU Histidine kinase ASA_1507 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASA_1508 ENOG4107QNR UPF0135 protein ASA_1509 ENOG4108V3E phosphoribosylglycinamide formyltransferase ASA_1510 ENOG4105CXB phosphoribosylaminoimidazole synthetase ASA_1511 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ASA_1514 ENOG4108I9X Isocitrate lyase ASA_1515 ENOG4107QP3 malate synthase g ASA_1518 ENOG4108Z6B deaminase ASA_1519 ENOG4105C8U phosphate abc transporter ASA_1520 ENOG4105E2Z phosphate ABC transporter (Permease ASA_1521 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASA_1523 ENOG4105C37 (CBS) domain ASA_1526 ENOG4105D5Q Arginine ornithine antiporter ASA_1528 ENOG4105CDA abc transporter atp-binding protein ASA_1529 ENOG4105E5Q amino acid AbC transporter ASA_1530 ENOG4106PMH Extracellular solute-binding protein family 3 ASA_1531 ENOG4105BZU Histidine kinase ASA_1532 ENOG4105CXY transporter ASA_1533 ENOG4105BZU Histidine kinase ASA_1534 ENOG4108KX4 response regulator ASA_1535 ENOG4105NXH GreA GreB family elongation factor ASA_1539 ENOG4105G6Z alkaline phosphatase ASA_1540 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ASA_1541 ENOG4105DGU Histone deacetylase ASA_1543 ENOG4105DVT helicase ASA_1544 ENOG4105QMY Porin Gram-negative type ASA_1546 ENOG4105CGF Aromatic amino acid aminotransferase ASA_1547 ENOG4105D7A ATP-binding protein ASA_1550 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ASA_1551 ENOG4105BZ1 (ABC) transporter ASA_1552 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ASA_1553 ENOG4105W49 UPF0434 protein ASA_1554 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ASA_1555 ENOG4105WH1 Two component transcriptional regulator luxr family ASA_1556 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ASA_1591 ENOG4105ED4 portal protein ASA_1604 ENOG4105RDA repressor ASA_1606 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASA_1608 ENOG4105EQ2 LysR family Transcriptional regulator ASA_1609 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ASA_1612 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ASA_1614 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASA_1615 ENOG4105C8N cysteinyl-tRNA synthetase ASA_1628 ENOG4108ZJT translation initiation factor, Sui1 ASA_1634 ENOG4105CZX twitching motility protein ASA_1636 ENOG4105BZU Histidine kinase ASA_1637 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ASA_1638 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) ASA_1639 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASA_1640 ENOG41080IJ Diacylglycerol kinase ASA_1641 ENOG4108JQ1 Dehydrogenase ASA_1642 ENOG4105E66 phosphoriboisomerase A ASA_1643 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ASA_1647 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ASA_1648 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ASA_1649 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ASA_1650 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASA_1651 ENOG4107QS8 (LipO)protein ASA_1657 ENOG4108MK9 spermidine N(1)-acetyltransferase ASA_1658 ENOG4105C1J atp-dependent rna helicase ASA_1663 ENOG4108Z4X TRANSCRIPTIONal ASA_1666 ENOG4105BZ8 glutamate synthase ASA_1667 ENOG4105CBC glutamate synthase ASA_1668 ENOG4105N5T Radical SAM Protein ASA_1670 ENOG4105C42 Type I secretion membrane fusion protein (HlyD ASA_1682 ENOG4105RKW reductase (By ASA_1683 ENOG4105CSX c4-dicarboxylate anaerobic carrier ASA_1684 ENOG4105CHM Aminotransferase ASA_1686 ENOG41090BQ Glutaredoxin ASA_1687 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ASA_1688 ENOG4105CFI type iii restriction protein res subunit ASA_1689 ENOG4105EFX secretion protein, HlyD family ASA_1690 ENOG4105KK7 inner membrane protein YiaW ASA_1692 ENOG4108NEV two component transcriptional regulator, LytTR family ASA_1693 ENOG4108HRK Histidine kinase ASA_1694 ENOG4105CPI Metal Dependent Phosphohydrolase ASA_1695 ENOG4108EKI Dehydrogenase ASA_1697 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ASA_1698 ENOG4107QSI ABC, transporter ASA_1699 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASA_1700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASA_1701 ENOG4105C3U ABC transporter ASA_1702 ENOG4108JQ7 (ABC) transporter ASA_1703 ENOG4105DU1 integral membrane protein, terc ASA_1704 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASA_1706 ENOG4105CK2 sodium dicarboxylate symporter ASA_1709 ENOG4105CD3 dihydroorotase ASA_1711 ENOG4108NVR Methyl-accepting chemotaxis ASA_1712 ENOG4105K59 histidine triad (HIT) protein ASA_1719 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASA_1720 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASA_1722 ENOG4107SDU Methyl-accepting chemotaxis ASA_1724 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1725 ENOG4105C8S subunit m ASA_1726 ENOG4105D65 subunit l ASA_1727 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1728 ENOG4107UFS subunit j ASA_1729 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1730 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ASA_1731 ENOG4108IEH NADH dehydrogenase subunit g ASA_1732 ENOG4107QIZ NADH dehydrogenase ASA_1733 ENOG4105GKE subunit e ASA_1734 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1735 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1736 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ASA_1737 ENOG4105ER2 Ompa motb domain protein ASA_1741 ENOG4105HA9 of methanol dehydrogenase type ASA_1743 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) ASA_1744 ENOG4105EZ7 amino acid ABC transporter ASA_1745 ENOG4106TNF Periplasmic binding protein ASA_1746 ENOG4105EAD ABC transporter ASA_1747 ENOG4105CDA abc transporter atp-binding protein ASA_1749 ENOG4105VFU Rna-binding protein ASA_1750 ENOG4107RGM aldo keto reductase ASA_1752 ENOG4108RU0 short-chain dehydrogenase reductase ASA_1755 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_1756 ENOG4105CBN LysR family transcriptional regulator ASA_1759 ENOG4105BZU Histidine kinase ASA_1760 ENOG4108DBC nitroreductase ASA_1763 ENOG4108SC4 )-transporter ASA_1764 ENOG4105CMU LysR family (Transcriptional regulator ASA_1765 ENOG4107R11 Transcriptional regulator ASA_1766 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ASA_1767 ENOG4105CAT Cytidine monophosphate kinase ASA_1768 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ASA_1769 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASA_1771 ENOG4105CFV Tetratricopeptide repeat protein ASA_1772 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ASA_1775 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ASA_1776 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ASA_1777 ENOG4105VRT cytoplasmic protein ASA_1778 ENOG4108WBT adenosyltransferase ASA_1781 ENOG4107S6Z Na H antiporter ASA_1782 ENOG4107104 thymidine kinase ASA_1784 ENOG4108RMJ sensory transduction regulator ASA_1786 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASA_1788 ENOG4105E3S small subunit ASA_1789 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ASA_1790 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit ASA_1791 ENOG4105DPX Hydrogenase, large subunit ASA_1792 ENOG4108USZ hydrogenase ASA_1793 ENOG4108WGS hydrogenase 2-specific chaperone ASA_1795 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASA_1796 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASA_1798 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASA_1799 ENOG4107RSS Hydrogenase accessory protein HypB ASA_1800 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ASA_1801 ENOG4105C45 hydrogenase expression formation protein (HypE) ASA_1802 ENOG4105CQS hydrogenase expression formation protein HypD ASA_1803 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF ASA_1805 ENOG4105EM7 Selenocysteine-specific translation elongation factor ASA_1806 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ASA_1808 ENOG4108MG9 hydrogenase 3 maturation protease ASA_1809 ENOG4105I6X formate hydrogenlyase maturation ASA_1810 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit ASA_1812 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ASA_1813 ENOG4107TDF Formate hydrogenlyase subunit 4 ASA_1814 ENOG4108JPZ Monovalent cation H antiporter subunit D ASA_1815 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) ASA_1816 ENOG4105DFH Transport of potassium into the cell (By similarity) ASA_1820 ENOG4108RC0 Electron transport protein ASA_1824 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASA_1825 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ASA_1826 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ASA_1827 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ASA_1828 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ASA_1829 ENOG4105WJG Glutathione ASA_1830 ENOG4107RE1 Inosine-guanosine kinase ASA_1831 ENOG4105C8Q Methyl-accepting chemotaxis ASA_1834 ENOG4105BZU Histidine kinase ASA_1835 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASA_1837 ENOG4105F3T (LipO)protein ASA_1839 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASA_1840 ENOG4105WQI isochorismatase ASA_1841 ENOG4105CEY Amp-dependent synthetase and ligase ASA_1842 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ASA_1844 ENOG4105C0W non-ribosomal peptide synthetase ASA_1845 ENOG4108MES Periplasmic binding protein ASA_1846 ENOG4108TSE Transferase ASA_1847 ENOG4105E0A ABC, transporter ASA_1848 ENOG4105TVJ transport system, permease ASA_1849 ENOG4105DQ5 transport system permease protein ASA_1850 ENOG4105D05 Receptor ASA_1853 ENOG4105QZU Inner membrane protein YfeZ ASA_1854 ENOG4107QUT magnesium and cobalt transport protein CorA ASA_1855 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ASA_1856 ENOG4105BZJ Electron transfer flavoprotein ASA_1857 ENOG4105C10 Electron transfer flavoprotein ASA_1858 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ASA_1859 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ASA_1860 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASA_1861 ENOG4108NVR Methyl-accepting chemotaxis ASA_1862 ENOG4105D4P Coproporphyrinogen iii oxidase ASA_1863 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASA_1864 ENOG4105DS1 cytochrome b561 ASA_1865 ENOG4105SG9 biopolymer transport protein, ExbD ASA_1868 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASA_1869 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASA_1874 ENOG4105FQ6 thiopurine methyltransferase ASA_1875 ENOG4107QXK peptidase ASA_1876 ENOG4108BY2 phosphohistidine phosphatase ASA_1878 ENOG4108IPJ Membrane ASA_1879 ENOG4108J59 Extracellular solute-binding protein, family 5 ASA_1880 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ASA_1881 ENOG4108JA2 transcriptioN-repair coupling factor ASA_1883 ENOG4105D60 lipoprotein releasing system transmembrane protein ASA_1884 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASA_1885 ENOG4105D60 lipoprotein releasing system transmembrane protein ASA_1888 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ASA_1889 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASA_1890 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ASA_1891 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ASA_1892 ENOG4105K70 DNA-binding protein ASA_1893 ENOG4105EIN peptidylprolyl cis-trans isomerase ASA_1894 ENOG4105C5H ABC transporter ASA_1895 ENOG4107QN1 sodium solute ASA_1896 ENOG41062QD Membrane ASA_1899 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASA_1900 ENOG4105BZG amino acid carrier protein ASA_1901 ENOG410849A acetyltransferase, (GNAT) family ASA_1903 ENOG4106HK8 GPR1 FUN34 yaaH family protein ASA_1910 ENOG4105E39 Enoyl-CoA hydratase ASA_1911 ENOG4107QX3 carboxylase ASA_1912 ENOG4105C1G acyl-Coa dehydrogenase ASA_1913 ENOG4105C26 Dehydrogenase ASA_1914 ENOG4105C1G acyl-Coa dehydrogenase ASA_1915 ENOG4105E39 Enoyl-CoA hydratase ASA_1916 ENOG4105E39 Enoyl-CoA hydratase ASA_1917 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASA_1918 ENOG4105CHR reductase ASA_1919 ENOG4105D5Q Arginine ornithine antiporter ASA_1920 ENOG4105HF0 Membrane ASA_1929 ENOG4105BZU Histidine kinase ASA_1930 ENOG4108DG9 Smr protein MutS2 ASA_1931 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ASA_1932 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ASA_1934 ENOG4105C1J atp-dependent rna helicase ASA_1937 ENOG4105E0U tyrosine-specific transport protein ASA_1938 ENOG4107B7Y DNA-binding transcriptional regulator FruR ASA_1939 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ASA_1940 ENOG4105DE4 1-phosphofructokinase ASA_1941 ENOG4105DM4 PTS System ASA_1942 ENOG4105XZD Fe-S protein ASA_1943 ENOG4105CA3 membrane-bound lytic murein transglycosylase ASA_1944 ENOG4105XPH Ferredoxin ASA_1945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASA_1946 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASA_1947 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASA_1948 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASA_1949 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASA_1953 ENOG4105C22 threonyL-tRNA synthetase ASA_1954 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ASA_1956 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ASA_1957 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ASA_1958 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ASA_1959 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASA_1963 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ASA_1965 ENOG4108KHX Diguanylate cyclase ASA_1966 ENOG4105ETE Transcriptional regulator (LacI family ASA_1967 ENOG4108RVA ribokinase ASA_1968 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ASA_1969 ENOG4105CNN ABC, transporter ASA_1971 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ASA_1972 ENOG4108K3A Glutathione S-transferase ASA_1975 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ASA_1976 ENOG4105Q9Y Universal stress protein ASA_1977 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ASA_1980 ENOG4105C59 p-type ATPase ASA_1982 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) ASA_1985 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ASA_1987 ENOG4108ZGC gaf domain protein ASA_1988 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) ASA_1989 ENOG4105CN1 protease ASA_1990 ENOG4105CD8 aminopeptidase N ASA_1992 ENOG4105C7I Dehydrogenase ASA_1993 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ASA_1994 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ASA_1995 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ASA_1997 ENOG4105C5H ABC transporter ASA_1999 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) ASA_2000 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ASA_2001 ENOG4105DAN ATP-dependent protease ASA_2016 ENOG4105F5W AtP-binding protein ASA_2017 ENOG4105D70 Integrase catalytic subunit ASA_2031 ENOG4105PDP Short chain dehydrogenase ASA_2039 ENOG4105DXD 2-methylcitrate dehydratase ASA_2040 ENOG4105BZN citrate synthase ASA_2041 ENOG4105CR4 methylisocitrate lyase ASA_2044 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASA_2047 ENOG4105F8V Hydrolase, tatD family ASA_2048 ENOG4107QRG dna polymerase iii ASA_2049 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ASA_2050 ENOG4105HHA aminodeoxychorismate lyase ASA_2051 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ASA_2052 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASA_2053 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASA_2054 ENOG4105CHR reductase ASA_2055 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ASA_2056 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASA_2057 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ASA_2058 ENOG4105VGS 50s ribosomal protein l32 ASA_2059 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ASA_2060 ENOG4108UHJ MAF-like protein ASA_2061 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 ASA_2062 ENOG4105EI2 Pseudouridine synthase ASA_2064 ENOG4105C03 ribonuclease ASA_2066 ENOG4105CJ3 phosphate transporter ASA_2067 ENOG4105DHP deoxycytidine triphosphate deaminase ASA_2068 ENOG4105DBI uridine monophosphokinase ASA_2069 ENOG4105D1F ATP-binding protein ASA_2070 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ASA_2072 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ASA_2074 ENOG4105DR4 Methyltransferase ASA_2075 ENOG4105FAT Acyl-transferase ASA_2077 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ASA_2078 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) ASA_2079 ENOG4105C5X domain protein ASA_2080 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ASA_2082 ENOG4105CQ7 ATP-dependent helicase ASA_2084 ENOG4105WH1 Two component transcriptional regulator luxr family ASA_2086 ENOG4105DWD nucleoside recognition domain protein ASA_2087 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ASA_2088 ENOG4107QMP dna polymerase iii subunits gamma and tau ASA_2089 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ASA_2090 ENOG4105WD1 Membrane ASA_2091 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ASA_2095 ENOG4105CEY Amp-dependent synthetase and ligase ASA_2096 ENOG4108MXF Alpha Beta Hydrolase ASA_2098 ENOG41072GX Peptidase M22 Glycoprotease ASA_2099 ENOG4105DVT helicase ASA_2101 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ASA_2102 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ASA_2103 ENOG4105CIH Imidazole acetol-phosphate transaminase ASA_2104 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ASA_2105 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ASA_2106 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ASA_2107 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_2109 ENOG4105BZU Histidine kinase ASA_2110 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ASA_2111 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ASA_2113 ENOG4105D29 Helix-turn-helix type 11 domain protein ASA_2120 ENOG4105W5Q DNA repair protein (RadC ASA_2135 ENOG4105K3G Periplasmic Protein ASA_2137 ENOG41062B0 ABC transporter, permease ASA_2138 ENOG4107R9N ABC transporter ASA_2139 ENOG4105C2J ABC transporter ASA_2140 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator ASA_2144 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ASA_2145 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASA_2146 ENOG4105CHU acetyl-coa acetyltransferase ASA_2147 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASA_2156 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASA_2157 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASA_2158 ENOG4105D58 Diguanylate phosphodiesterase ASA_2159 ENOG4105CHU acetyl-coa acetyltransferase ASA_2161 ENOG4105CK2 sodium dicarboxylate symporter ASA_2162 ENOG4105NBK UPF0345 protein ASA_2163 ENOG4105EJQ L-serine dehydratase ASA_2164 ENOG4105EJQ L-serine dehydratase ASA_2165 ENOG4105CVE Lytic murein transglycosylase ASA_2166 ENOG4105VNG YcgL domain-containing protein ASA_2167 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ASA_2168 ENOG4107QMS site-determining protein ASA_2169 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) ASA_2171 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase ASA_2172 ENOG4105XW2 UPF0263 protein ASA_2179 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ASA_2180 ENOG4108SXK Transporter Drug Metabolite Exporter family ASA_2181 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ASA_2182 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 ASA_2183 ENOG4108R6K riboflavin synthase, subunit alpha ASA_2184 ENOG4105W1I UPF0253 protein ASA_2185 ENOG4107QI1 Mate efflux family protein ASA_2190 ENOG4105CQ2 DNA polymerase ASA_2192 ENOG4105BZU Histidine kinase ASA_2195 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ASA_2196 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ASA_2198 ENOG4105DUM transcriptional regulator, lysR family ASA_2200 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ASA_2201 ENOG4105CBN LysR family transcriptional regulator ASA_2205 ENOG4107MBR 17 kDa surface antigen ASA_2209 ENOG4105EHG Permease protein ASA_2213 ENOG4108VWS Yaeq family ASA_2226 ENOG4105K6T rare lipoprotein A ASA_2227 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) ASA_2230 ENOG4106371 Methyltransferase ASA_2231 ENOG4107S90 membrAne ASA_2233 ENOG4105CTQ phosphohexokinase ASA_2242 ENOG4105PAD Hydrolase ASA_2243 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASA_2254 ENOG4105CPB ATP-dependent endonuclease of the OLD family ASA_2255 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) ASA_2257 ENOG4105VP0 transcriptional regulator, lysR family ASA_2258 ENOG4105EJ9 Membrane ASA_2259 ENOG4106IUH DTW domain containing protein ASA_2261 ENOG4105CPF Cell wall formation (By similarity) ASA_2263 ENOG4108V06 Glutathione peroxidase ASA_2264 ENOG4105C1J atp-dependent rna helicase ASA_2265 ENOG4105K5X acetyltransferase ASA_2267 ENOG4105KK4 UPF0060 membrane protein ASA_2275 ENOG41061CK Antibiotic biosynthesis monooxygenase ASA_2276 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) ASA_2280 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ASA_2282 ENOG4105WQ3 Rna-binding protein ASA_2284 ENOG4105BZ1 (ABC) transporter ASA_2286 ENOG4105BZU Histidine kinase ASA_2287 ENOG4105K63 Thioredoxin ASA_2288 ENOG4105C8P )-transporter ASA_2289 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ASA_2293 ENOG4105CRQ synthase (Component I) ASA_2295 ENOG4105C44 Serine transporter ASA_2296 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ASA_2297 ENOG4105C9U ATP-dependent DNA helicase RecQ ASA_2298 ENOG4105CYN Serine protein kinase ASA_2300 ENOG4105ED1 spovr family ASA_2301 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) ASA_2302 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASA_2303 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ASA_2304 ENOG4105DQR SNARE associated Golgi ASA_2306 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ASA_2308 ENOG4105D0C transport protein ASA_2309 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASA_2313 ENOG4108MRH transcriptional regulatory protein ASA_2314 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASA_2315 ENOG4105E2R ROK family ASA_2316 ENOG4105C8Q Methyl-accepting chemotaxis ASA_2317 ENOG4105K5B UPF0225 protein ASA_2318 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ASA_2319 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ASA_2320 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ASA_2322 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit ASA_2323 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ASA_2324 ENOG4105DVI reductase, NrfD ASA_2325 ENOG4105DA4 cytochrome c-type biogenesis protein ASA_2326 ENOG4107QX9 Thiol disulfide interChange protein ASA_2327 ENOG4108DMF Cytochrome C biogenesis protein ASA_2329 ENOG41061WM D-Alanyl-D-Alanine ASA_2330 ENOG4105C0F tryptophanase EC 4.1.99.1 ASA_2332 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ASA_2333 ENOG4105MWK D-amino acid dehydrogenase, small subunit ASA_2338 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ASA_2339 ENOG4105DZ2 Transcriptional regulator ASA_2341 ENOG4105E0K tonB-dependent siderophore receptor ASA_2342 ENOG4105UEI Transcriptional Regulator AraC Family ASA_2344 ENOG4105CR8 Transcriptional regulator ASA_2345 ENOG4108RYK Nad-dependent epimerase dehydratase ASA_2349 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASA_2350 ENOG4105DDY UPF0142 protein ycaO ASA_2351 ENOG4105TMB Formate nitrite transporter ASA_2352 ENOG4105C6N Formate acetyltransferase ASA_2354 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ASA_2355 ENOG4105CMV Succinyl-CoA synthetase subunit beta ASA_2356 ENOG4105C7S Dehydrogenase ASA_2357 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ASA_2358 ENOG4105E33 succinate dehydrogenase ASA_2359 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ASA_2360 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ASA_2361 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ASA_2362 ENOG4105BZN citrate synthase ASA_2365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASA_2366 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ASA_2368 ENOG4105CEE C4-dicarboxylate transporter ASA_2371 ENOG4108VKG metal-dependent hydrolase ASA_2374 ENOG4105NRA 50s ribosomal protein l31 type b ASA_2376 ENOG4105CA9 Pyruvate kinase ASA_2377 ENOG4105CI1 PTS System ASA_2378 ENOG4105C4C beta-galactosidase ASA_2380 ENOG4105EG2 ABC transporter, permease ASA_2382 ENOG4107FKK extracellular solute-binding protein family 1 ASA_2388 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ASA_2389 ENOG41060NJ transcriptional regulator ASA_2390 ENOG4105CMR udp-glucose 4-epimerase ASA_2391 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ASA_2392 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ASA_2394 ENOG4105CNN ABC, transporter ASA_2395 ENOG4105C2J ABC transporter ASA_2396 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator ASA_2397 ENOG4105EF1 ribulokinase ASA_2399 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ASA_2400 ENOG4105ETT transcriptional Regulator, LysR family ASA_2405 ENOG4105CJB Exodeoxyribonuclease I ASA_2409 ENOG41067MG lrgb family ASA_2410 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) ASA_2411 ENOG4108IQE Amp-dependent synthetase and ligase ASA_2412 ENOG4105MH2 YfcL protein ASA_2414 ENOG4105EE5 Membrane protein terC ASA_2415 ENOG4105UYK outer membrane protein a ASA_2416 ENOG4108KHX Diguanylate cyclase ASA_2417 ENOG4108WS1 ASA_2419 ENOG41090A4 Pterin carbinolamine dehydratase ASA_2420 ENOG4105MIR Phenylalanine 4-monooxygenase ASA_2421 ENOG4106K28 UPF0283 membrane protein ASA_2422 ENOG4105CM6 amino acid regulated cytosolic protein ASA_2424 ENOG4105YYT phage shock protein B ASA_2425 ENOG41087YS Phage shock protein A ASA_2426 ENOG4105E51 psp operon transcriptional activator ASA_2427 ENOG4108J59 Extracellular solute-binding protein, family 5 ASA_2428 ENOG4108I5W peptide transport system, permease protein ASA_2429 ENOG4108EU3 peptide transport system, permease ASA_2430 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ASA_2431 ENOG4108JQ2 peptide transport system atp-binding protein ASA_2433 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ASA_2434 ENOG4105E96 Colicin v production protein ASA_2435 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ASA_2436 ENOG4105D1H recombination factor protein RarA ASA_2437 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) ASA_2438 ENOG4105CNU cell division protein FtsK ASA_2439 ENOG4105EW9 transcriptional regulator AsnC family ASA_2440 ENOG4105C3M thioredoxin reductase ASA_2441 ENOG4105BZU Histidine kinase ASA_2442 ENOG4107MBR 17 kDa surface antigen ASA_2443 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ASA_2444 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ASA_2445 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASA_2446 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASA_2447 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ASA_2448 ENOG4105VEQ Cold shock protein ASA_2449 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ASA_2455 ENOG4105CS6 Rhs element vgr protein ASA_2461 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASA_2474 ENOG4105CHH sulfate transporter ASA_2484 ENOG4108PCN EamA-like transporter family ASA_2485 ENOG4105DGN Electron transport complex ASA_2486 ENOG4108R3D Electron transport complex ASA_2488 ENOG4105D6A Electron transport complex ASA_2489 ENOG4108UQQ Electron transport complex ASA_2490 ENOG4105DZB Electron transport complex ASA_2491 ENOG4105CSM endonuclease III ASA_2492 ENOG4108UYE Lactoylglutathione lyase ASA_2493 ENOG4105EIY sodium-type flagellar protein motY ASA_2495 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ASA_2496 ENOG4105D3Y Na H antiporter ASA_2497 ENOG4105BZU Histidine kinase ASA_2499 ENOG4105C1J atp-dependent rna helicase ASA_2500 ENOG4105KA0 thioesterase Superfamily protein ASA_2502 ENOG4105CQB FAD linked oxidase domain protein ASA_2504 ENOG4105EE5 Membrane protein terC ASA_2505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASA_2506 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASA_2507 ENOG4105D4U had-superfamily hydrolase, subfamily iia ASA_2508 ENOG4105CKD glutathione-regulated potassium-efflux system protein ASA_2510 ENOG4105CAQ asparagine synthetase ASA_2515 ENOG4108TGY Glutathione S-transferase ASA_2516 ENOG4108RXX maleylacetoacetate isomerase ASA_2519 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ASA_2521 ENOG4108W1A pseudouridine synthase ASA_2523 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASA_2525 ENOG4108MN8 Membrane ASA_2526 ENOG4105EM2 membrane ASA_2527 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ASA_2528 ENOG4108S3P Sporulation domain protein ASA_2529 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ASA_2530 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ASA_2531 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ASA_2533 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASA_2534 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) ASA_2535 ENOG4105EYK Phosphatidylglycerophosphatase B ASA_2536 ENOG4105D01 (LipO)protein ASA_2544 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ASA_2545 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ASA_2547 ENOG4105C85 amino acid ASA_2566 ENOG4108302 MgtC SapB transporter ASA_2576 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ASA_2577 ENOG4107QZM n-acetylglutamate synthase ASA_2578 ENOG4105CFH Aspartokinase ASA_2580 ENOG4107T7U Sulfatase ASA_2581 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASA_2583 ENOG4105K8R UPF0145 protein ASA_2584 ENOG4105CEP NADH dehydrogenase ASA_2587 ENOG4105DPN Oligoendopeptidase f ASA_2589 ENOG4105CKW Inner membrane protein yedI ASA_2591 ENOG4107QIK phosphoribosylformylglycinamidine synthase ASA_2592 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASA_2594 ENOG4105VPD cellular component movement ASA_2595 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ASA_2596 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASA_2597 ENOG4105N21 Membrane ASA_2598 ENOG4105CUT histidyl-tRNA synthetase ASA_2599 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ASA_2600 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) ASA_2602 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ASA_2603 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ASA_2604 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASA_2606 ENOG4108ZIT Ferredoxin, 2FE-2S ASA_2607 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASA_2608 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) ASA_2610 ENOG4108Z4V iron-sulfur cluster assembly ASA_2611 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ASA_2612 ENOG4105C3J Cysteine desulfurase ASA_2614 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ASA_2616 ENOG4105XPQ lipid carrier protein ASA_2617 ENOG4105CFP Peptidase U32 ASA_2618 ENOG4106RZ4 Peptidase U32 ASA_2620 ENOG4105KHC sulfurtransferase ASA_2621 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASA_2622 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASA_2623 ENOG4105VIE preprotein translocase, subunit YajC ASA_2624 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ASA_2625 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ASA_2626 ENOG4105W87 Cbs domain ASA_2627 ENOG4105D3R alkyl hydroperoxide reductase ASA_2631 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ASA_2632 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ASA_2633 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASA_2634 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASA_2635 ENOG4105D0A hydroxylase ASA_2637 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ASA_2640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASA_2641 ENOG4105EJC lysr family transcriptional regulator ASA_2642 ENOG4105E5M Multidrug resistance protein D ASA_2643 ENOG4108RZA ABC transporter ASA_2644 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASA_2645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASA_2647 ENOG4105CYM Glutathione S-transferase ASA_2650 ENOG4108NVR Methyl-accepting chemotaxis ASA_2653 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ASA_2655 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ASA_2658 ENOG4105MQ3 flagellar protein FliS ASA_2662 ENOG4105I03 Flagellin ASA_2663 ENOG4105EN6 Membrane ASA_2665 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ASA_2667 ENOG4108JQB penicillin-binding protein 1C ASA_2668 ENOG4105DN3 alpha-2-macroglobulin domain protein ASA_2671 ENOG4105F1A Pyruvate formate-lyase ASA_2675 ENOG4105DSP amino acid AbC transporter ASA_2676 ENOG4106PMH Extracellular solute-binding protein family 3 ASA_2677 ENOG4108JEH abc transporter atp-binding protein ASA_2678 ENOG4105DWU Membrane ASA_2679 ENOG4108ZYK Acyl carrier protein phosphodiesterase ASA_2681 ENOG4105K89 arsenate reductase ASA_2683 ENOG4105ERG peptidase m48, ste24p ASA_2684 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ASA_2685 ENOG4105C02 permease ASA_2687 ENOG4105CSR polyphosphate kinase 2 ASA_2688 ENOG4108IJ9 (ABC) transporter ASA_2689 ENOG4105EG2 ABC transporter, permease ASA_2690 ENOG4105D56 permease protein ASA_2691 ENOG4107FKK extracellular solute-binding protein family 1 ASA_2692 ENOG4106V8H Nucleoid-associated protein ASA_2693 ENOG4105PAN UPF0352 protein ASA_2694 ENOG4105E68 Sulfatase ASA_2695 ENOG4105D05 Receptor ASA_2696 ENOG4105CUG Oligopeptidase b ASA_2700 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) ASA_2701 ENOG4108WFC UPF0438 protein yifE ASA_2704 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASA_2705 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ASA_2706 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ASA_2707 ENOG4105E98 transcriptional regulator DeoR family ASA_2708 ENOG4105CXY transporter ASA_2709 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ASA_2710 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ASA_2711 ENOG4105HEI LysR family (Transcriptional regulator ASA_2716 ENOG41067V3 Antibiotic biosynthesis monooxygenase ASA_2717 ENOG4105CV8 reductase ASA_2718 ENOG4105F27 Major Facilitator ASA_2720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASA_2721 ENOG4105C4M (Ubiquinol oxidase) subunit I ASA_2722 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASA_2723 ENOG4108Q2J Inner membrane protein YebE ASA_2725 ENOG4106428 Protein of unknown function (DUF2496) ASA_2729 ENOG4105DJ2 Major Facilitator Superfamily ASA_2730 ENOG4105FE9 pseudouridine synthase ASA_2731 ENOG4105D82 Glutamate dehydrogenase ASA_2733 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) ASA_2740 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ASA_2741 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASA_2746 ENOG4108YYC ycei family ASA_2747 ENOG4105CC0 LysR family Transcriptional regulator ASA_2749 ENOG4105CKU formyltetrahydrofolate synthetase ASA_2750 ENOG4105C8Q Methyl-accepting chemotaxis ASA_2752 ENOG4105EUJ GTP cyclohydrolase i ASA_2753 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASA_2754 ENOG4105D06 uba thif-type nad fad binding protein ASA_2755 ENOG4105QYK bacteriophage lambda Bor protein homolog ASA_2756 ENOG4105QYK bacteriophage lambda Bor protein homolog ASA_2759 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASA_2760 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ASA_2761 ENOG4105E0C molybdate abc transporter ASA_2762 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ASA_2763 ENOG4108ZAF Molybdopterin ASA_2764 ENOG4105M00 molybdopterin converting factor, subunit 1 ASA_2765 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASA_2766 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASA_2767 ENOG4105CUW cytochrome C-TYPE protein ASA_2769 ENOG4105GXZ Ferredoxin-type protein NapH ASA_2770 ENOG4108BGM Quinol dehydrogenase periplasmic component ASA_2771 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASA_2774 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASA_2775 ENOG4105BZU Histidine kinase ASA_2776 ENOG4105WH1 Two component transcriptional regulator luxr family ASA_2778 ENOG4105BZU Histidine kinase ASA_2780 ENOG4105CHW UPF0052 protein ASA_2782 ENOG4105E7A Glutamine amidotransferase ASA_2783 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASA_2784 ENOG4107QPN acyl-Coa dehydrogenase ASA_2785 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_2787 ENOG4107RZZ dna polymerase iii epsilon subunit ASA_2788 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASA_2789 ENOG4105D1A Methyltransferase ASA_2790 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ASA_2791 ENOG4105E9H Lytic Murein transglycosylase ASA_2794 ENOG4105NAU thioesterase Superfamily protein ASA_2796 ENOG41060NJ transcriptional regulator ASA_2797 ENOG4107SC1 transglycosylase ASA_2798 ENOG4105BZU Histidine kinase ASA_2799 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ASA_2802 ENOG4105MA0 exported protein ASA_2803 ENOG4105CFU surface antigen ASA_2805 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ASA_2806 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ASA_2808 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ASA_2810 ENOG4105VNH ABC transporter solute-binding protein ASA_2811 ENOG4105CXZ ABC transporter, permease ASA_2812 ENOG4108VGW abc transporter atp-binding protein ASA_2813 ENOG4108T9J Cdp-alcohol phosphatidyltransferase ASA_2814 ENOG4105CVE Lytic murein transglycosylase ASA_2817 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ASA_2818 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ASA_2819 ENOG4105EV9 Alpha Beta Hydrolase ASA_2821 ENOG4105NNH LexA regulated protein ASA_2822 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ASA_2824 ENOG41090R7 Ferric uptake ASA_2825 ENOG4105CX6 glutaminyL-tRNA synthetase ASA_2826 ENOG4105E2D ec 3.2.1.52 ASA_2827 ENOG4105CI1 PTS System ASA_2828 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ASA_2829 ENOG4105CE4 GlcNAc 6-P deacetylase ASA_2830 ENOG4105E2R ROK family ASA_2835 ENOG4107T8Q Glycosyl transferase (Group 1 ASA_2839 ENOG4105F5W AtP-binding protein ASA_2840 ENOG4105D70 Integrase catalytic subunit ASA_2842 ENOG4105DIJ Phosphoethanolamine transferase ASA_2843 ENOG4105CDY transcriptional regulatory protein ASA_2844 ENOG4105C9M aspartyl-trna synthetase ASA_2845 ENOG41081XQ Conserved Protein ASA_2846 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) ASA_2847 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ASA_2851 ENOG4105D3R alkyl hydroperoxide reductase ASA_2853 ENOG4105C5Q Transcriptional regulator ASA_2855 ENOG4108QBX (LipO)protein ASA_2857 ENOG4107RGH Aldehyde dehydrogenase ASA_2858 ENOG4108RZE Tetr family transcriptional regulator ASA_2860 ENOG4105C0A alcohol dehydrogenase ASA_2862 ENOG4105C6T cysteine synthase ASA_2866 ENOG4105UQX Mate efflux family protein ASA_2868 ENOG4105Z2P Protein of unknown function (DUF465) ASA_2871 ENOG4105QVC MOSC domain-containing protein ASA_2871 ENOG4105QVC MOSC domain-containing protein ASA_2872 ENOG4107SDU Methyl-accepting chemotaxis ASA_2873 ENOG4105D0M Protease HtpX homolog ASA_2874 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ASA_2875 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ASA_2876 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASA_2877 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ASA_2878 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASA_2881 ENOG4105C5S asparaginyl-tRNA synthetase ASA_2882 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASA_2886 ENOG4105KUZ arsenate reductase ASA_2887 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASA_2890 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ASA_2894 ENOG410829K Lysine exporter protein (Lyse ygga) ASA_2895 ENOG4108N3W hemolysin secretion protein ASA_2896 ENOG4105RX8 Protein of unknown function (DUF1523) ASA_2899 ENOG4105DU0 nucleoside hydrolase ASA_2900 ENOG4105D3G Pseudouridine synthase ASA_2901 ENOG4107SXA Phosphorylase ASA_2902 ENOG4105C0A alcohol dehydrogenase ASA_2910 ENOG4107U53 septum site-determining protein minD ASA_2918 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASA_2919 ENOG4105K4T epimerase ASA_2920 ENOG4105VDB UPF0125 protein ASA_2921 ENOG4108Z1B Cyclase dehydrase ASA_2922 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ASA_2938 ENOG4105W8I Transcriptional regulator ASA_2940 ENOG4105BZC d-serine deaminase ASA_2942 ENOG4108HMX isocitrate dehydrogenase (NADP) ASA_2943 ENOG4106R3P AraC family transcriptional regulator ASA_2944 ENOG4105EIP mannose-6-phosphate isomerase ASA_2950 ENOG4105C87 Aminotransferase class I and II ASA_2951 ENOG4105CI1 PTS System ASA_2952 ENOG4107P2S Transcriptional regulator ASA_2956 ENOG4107RDB Major Facilitator ASA_2957 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ASA_2958 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) ASA_2959 ENOG4105CCU oxidase (Subunit III) ASA_2960 ENOG4105BZ9 Cytochrome C oxidase, subunit I ASA_2961 ENOG4105E2S oxidase) subunit II ASA_2972 ENOG4105CGK Exodeoxyribonuclease III ASA_2977 ENOG4105EP1 Efflux transporter rnd family, mfp subunit ASA_2978 ENOG4108IJF Heavy metal efflux pump, CzcA ASA_2980 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ASA_2981 ENOG4105BZU Histidine kinase ASA_2986 ENOG41080HT Transcriptional regulator, arsr family ASA_2990 ENOG4105WBN Transcriptional regulator (LacI family ASA_2991 ENOG4108HKT sucrose-6-phosphate hydrolase ASA_2993 ENOG4105D7K pfkb domain protein ASA_2995 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASA_2996 ENOG4105CFG Acts as a chaperone (By similarity) ASA_2997 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ASA_2998 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ASA_2999 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ASA_3001 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ASA_3003 ENOG4105DJY efflux transporter, rnd family, mfp subunit ASA_3004 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASA_3005 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ASA_3006 ENOG4105Q26 Siderophore-interacting protein ASA_3009 ENOG4105D5G Transposase ASA_3015 ENOG4105EZV Transcriptional regulator ASA_3018 ENOG4105CJP fad dependent oxidoreductase ASA_3019 ENOG4107VRI Transcriptional regulator ASA_3020 ENOG4105C26 Dehydrogenase ASA_3021 ENOG4108JPW Aminotransferase ASA_3022 ENOG4105CUB amino acid ASA_3023 ENOG4105CUB amino acid ASA_3025 ENOG4108V1T peptidylprolyl cis-trans isomerase ASA_3026 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ASA_3029 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type ASA_3032 ENOG4108UK5 Transposase ASA_3038 ENOG4105D98 threonine synthase ASA_3039 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ASA_3041 ENOG4106FVC RNA methyltransferase ASA_3042 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) ASA_3045 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASA_3047 ENOG41065U4 response regulator ASA_3050 ENOG4108JJ9 ABC, transporter ASA_3051 ENOG4108JJ8 (ABC) transporter ASA_3055 ENOG4108R96 Methyltransferase, YaeB family ASA_3059 ENOG4105C6T cysteine synthase ASA_3060 ENOG4105KZ7 phosphocarrier protein hpr ASA_3062 ENOG4105C5Y PTS System ASA_3063 ENOG4105BZU Histidine kinase ASA_3065 ENOG4105CPW cytochrome b561 ASA_3067 ENOG4105EYH Exonuclease ASA_3068 ENOG4107RH8 nuclease SbcCD subunit D ASA_3070 ENOG4105DH7 May be involved in recombination (By similarity) ASA_3071 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ASA_3074 ENOG4105CA9 Pyruvate kinase ASA_3075 ENOG4105EGS Mechanosensitive ion channel ASA_3081 ENOG4108J1Q ASA_3082 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASA_3084 ENOG4105BZU Histidine kinase ASA_3087 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component ASA_3088 ENOG4108IUZ ABC transporter ASA_3089 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ASA_3090 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASA_3091 ENOG4105DR8 Membrane ASA_3092 ENOG4108ESY Metal dependent phosphohydrolase ASA_3093 ENOG4107SDU Methyl-accepting chemotaxis ASA_3095 ENOG4105XIQ Protein of unknown function (DUF2517) ASA_3099 ENOG4105BZU Histidine kinase ASA_3102 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASA_3104 ENOG4108JQ7 (ABC) transporter ASA_3106 ENOG4105RD7 BadF BadG BcrA BcrD ASA_3107 ENOG4105E2D ec 3.2.1.52 ASA_3108 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASA_3111 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASA_3112 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) ASA_3113 ENOG4105ERU peptidase ASA_3114 ENOG4105UBK short-chain dehydrogenase reductase ASA_3115 ENOG4105C5Q Transcriptional regulator ASA_3117 ENOG4105C87 Aminotransferase class I and II ASA_3120 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ASA_3121 ENOG4108V1U phospholipid-binding protein ASA_3123 ENOG4107T9C Alpha amylase catalytic region ASA_3130 ENOG4105BZU Histidine kinase ASA_3131 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ASA_3132 ENOG4105C9K Endothelin-converting enzyme 1 ASA_3134 ENOG4105C5H ABC transporter ASA_3135 ENOG4105KNA -acetyltransferase ASA_3136 ENOG4105DVH amino acid ASA_3137 ENOG4105C44 Serine transporter ASA_3138 ENOG4105EQ2 LysR family Transcriptional regulator ASA_3140 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) ASA_3141 ENOG4105CXN decarboxylase ASA_3142 ENOG4105D5Q Arginine ornithine antiporter ASA_3143 ENOG4108M3R transcriptional activator CadC ASA_3144 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ASA_3145 ENOG4105C0B DNA polymerase III (alpha subunit) ASA_3146 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASA_3147 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASA_3148 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASA_3149 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ASA_3150 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASA_3151 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ASA_3153 ENOG4105DZP Membrane-associated zinc metalloprotease ASA_3154 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ASA_3155 ENOG4105KNE Phosphatidate cytidylyltransferase ASA_3156 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ASA_3157 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ASA_3158 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ASA_3159 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ASA_3160 ENOG4105CE9 30S ribosomal protein S2 ASA_3162 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ASA_3163 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ASA_3164 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ASA_3165 ENOG4108T8E UPF0325 protein ASA_3166 ENOG4105CI1 PTS System ASA_3167 ENOG4107W52 maltose operon periplasmic protein ASA_3168 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ASA_3169 ENOG4105QDK Flavodoxin ASA_3170 ENOG4105DR9 pseudouridine synthase ASA_3171 ENOG4105WP7 tRNA pseudouridine synthase C ASA_3176 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein ASA_3177 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) ASA_3178 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ASA_3180 ENOG4105BZU Histidine kinase ASA_3181 ENOG4105EWT decarboxylase family ASA_3182 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease ASA_3183 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ASA_3185 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) ASA_3186 ENOG4105M08 Membrane ASA_3188 ENOG4105ETT transcriptional Regulator, LysR family ASA_3189 ENOG4105C8Q Methyl-accepting chemotaxis ASA_3190 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ASA_3193 ENOG4105CJ2 (LipO)protein ASA_3194 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ASA_3195 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_3196 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_3197 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_3198 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_3199 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASA_3200 ENOG4105M85 Bola protein ASA_3201 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASA_3203 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASA_3205 ENOG4105EYM Major Facilitator superfamily ASA_3206 ENOG4105DRB nucleoside-specific channel-forming protein ASA_3207 ENOG4108VPT UPF0234 protein ASA_3208 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ASA_3209 ENOG4107S0N DJ-1 family ASA_3213 ENOG4105E2V Glycosyltransferase 36 ASA_3216 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASA_3217 ENOG4105CMR udp-glucose 4-epimerase ASA_3219 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) ASA_3220 ENOG4108RMU ferritin dps family protein ASA_3225 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASA_3228 ENOG4107FW0 short-chain dehydrogenase reductase ASA_3230 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASA_3231 ENOG4108XDN Transcriptional regulator ASA_3232 ENOG4107SEY Conserved Protein ASA_3238 ENOG4105CQC Prephenate dehydratase ASA_3245 ENOG4108W2P Methyl-accepting chemotaxis ASA_3247 ENOG4105E1F short-chain dehydrogenase reductase ASA_3252 ENOG4105CTD carboxy-peptidase ASA_3255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASA_3257 ENOG4105XDF Protein of unknown function (DUF1272) ASA_3260 ENOG4105N14 lysine exporter protein LysE YggA ASA_3262 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASA_3263 ENOG4105C8Q Methyl-accepting chemotaxis ASA_3264 ENOG4108VYJ response regulator receiver protein ASA_3266 ENOG4105CBS Chea signal transduction histidine kinase ASA_3268 ENOG4108V3W Chemotaxis protein, CheW ASA_3269 ENOG4105C8Q Methyl-accepting chemotaxis ASA_3270 ENOG4105BZU Histidine kinase ASA_3271 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) ASA_3272 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASA_3273 ENOG4105C9B Cysteine desulfurase ASA_3277 ENOG4105BZU Histidine kinase ASA_3283 ENOG4108NJZ Sensory box GGDEF EAL domain protein ASA_3284 ENOG4105CFP Peptidase U32 ASA_3285 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ASA_3286 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASA_3287 ENOG4105CDU Replicative dna helicase ASA_3291 ENOG4105CGH 5'-nucleotidase ASA_3295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASA_3296 ENOG4108V1T peptidylprolyl cis-trans isomerase ASA_3298 ENOG4105VRX Protein slyX homolog ASA_3299 ENOG4108YZY peptidylprolyl cis-trans isomerase ASA_3300 ENOG4105VKU nucleicacid-binding protein ASA_3302 ENOG4107R88 Chemotaxis protein (CheV) ASA_3303 ENOG4105DNZ Alpha Beta Hydrolase ASA_3305 ENOG4105YP7 UPF0270 protein ASA_3306 ENOG4105C6Y Udp-glucose 6-dehydrogenase ASA_3307 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ASA_3308 ENOG4105CKK Glycosyl transferase, family 2 ASA_3310 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) ASA_3311 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) ASA_3312 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) ASA_3313 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) ASA_3314 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ASA_3317 ENOG4108UKZ OsmC family ASA_3318 ENOG4107RYR Transcriptional regulator, Crp Fnr family ASA_3320 ENOG4108M1A Chitin-binding protein ASA_3321 ENOG4108MA4 Peptidase M66 ASA_3325 ENOG4105VMP Transcriptional regulator ASA_3327 ENOG4105D8G Major Facilitator superfamily ASA_3328 ENOG4105D05 Receptor ASA_3332 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related ASA_3333 ENOG41090JE Utilization Protein ASA_3335 ENOG4105EHG Permease protein ASA_3341 ENOG4105C5H ABC transporter ASA_3344 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ASA_3345 ENOG4108S0S Nucleotidyl transferase ASA_3346 ENOG4105EHM Aminoglycoside phosphotransferase ASA_3347 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ASA_3349 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ASA_3350 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ASA_3351 ENOG4105NWN ApaG protein ASA_3352 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ASA_3355 ENOG4105DEN Luciferase family ASA_3357 ENOG4108ESY Metal dependent phosphohydrolase ASA_3359 ENOG4105CEY Amp-dependent synthetase and ligase ASA_3360 ENOG4105DWD nucleoside recognition domain protein ASA_3361 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ASA_3362 ENOG4105K46 50S ribosomal protein l27 ASA_3363 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ASA_3364 ENOG4105EAH synthase ASA_3366 ENOG4105EPW hflc protein ASA_3367 ENOG4107QJR hflk protein ASA_3368 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ASA_3369 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ASA_3370 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ASA_3371 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ASA_3372 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ASA_3373 ENOG4105K8N protein family UPF0079, ATPase ASA_3379 ENOG4108UMI ABC transporter, permease ASA_3380 ENOG4105D01 (LipO)protein ASA_3381 ENOG4105MDZ Transcriptional activator rfaH ASA_3382 ENOG4108N3W hemolysin secretion protein ASA_3387 ENOG4105BZU Histidine kinase ASA_3392 ENOG4105EXG Transcriptional regulator ASA_3394 ENOG4107QWK SAICAR synthetase ASA_3395 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASA_3396 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASA_3397 ENOG4105RH4 Glycine cleavage system transcriptional repressor ASA_3398 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ASA_3399 ENOG4105XWI UPF0304 protein ASA_3400 ENOG4105PQ6 UPF0208 membrane protein ASA_3401 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASA_3402 ENOG4105C6K Malic enzyme ASA_3403 ENOG4108ZP8 Acetolactate synthase small subunit ASA_3404 ENOG4105C7K acetolactate synthase ASA_3407 ENOG4105YVM Phosphoesterase, PA-phosphatase related ASA_3409 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASA_3411 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASA_3412 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASA_3415 ENOG4105DP9 ABC transporter ASA_3416 ENOG4106SMU thiamine transporter membrane protein ASA_3417 ENOG4107T0D ABC, transporter ASA_3418 ENOG4108IAB Phoh family ASA_3420 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASA_3426 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) ASA_3427 ENOG4105D3G Pseudouridine synthase ASA_3429 ENOG4105BZU Histidine kinase ASA_3431 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASA_3432 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASA_3434 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ASA_3435 ENOG4108IJ0 Aspartate ammonia-lyase ASA_3436 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASA_3438 ENOG4105EV4 Multidrug resistance protein mdtH ASA_3442 ENOG4105D9U N-acetyltransferase ASA_3446 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASA_3447 ENOG4105CSA Coproporphyrinogen iii oxidase ASA_3448 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system ASA_3451 ENOG4105DC1 bifunctional purine biosynthesis protein purh ASA_3452 ENOG4105C12 Phosphoribosylglycinamide synthetase ASA_3461 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASA_3462 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ASA_3463 ENOG4105KTH gatB Yqey ASA_3464 ENOG4105VCC 30S ribosomal protein S21 ASA_3465 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASA_3466 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASA_3467 ENOG4108K5P (LipO)protein ASA_3468 ENOG4108UM1 dedA family ASA_3469 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ASA_3470 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ASA_3471 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ASA_3472 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ASA_3473 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ASA_3474 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ASA_3475 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASA_3476 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ASA_3477 ENOG4105DXN mazG family ASA_3478 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASA_3479 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASA_3480 ENOG4105BZU Histidine kinase ASA_3481 ENOG4108W15 Protein of unknown function (DUF1456) ASA_3482 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ASA_3483 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ASA_3484 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ASA_3487 ENOG4105C3F Signal peptidase i ASA_3488 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ASA_3491 ENOG41069PW sigma-e factor negative regulatory protein ASA_3492 ENOG4105EMN RNA polymerase sigma factor ASA_3493 ENOG4108IYU L-aspartate oxidase ASA_3503 ENOG4105CJP fad dependent oxidoreductase ASA_3504 ENOG4105D2N Aldolase ASA_3505 ENOG4105BZA Phosphoglycerate kinase ASA_3506 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASA_3507 ENOG4105DKQ ROK family ASA_3510 ENOG4108UUE Transcriptional regulator ASA_3517 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASA_3520 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) ASA_3522 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ASA_3523 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ASA_3524 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASA_3525 ENOG4107QX8 SPFH domain, Band 7 family protein ASA_3526 ENOG4105G5H Membrane ASA_3527 ENOG4105C2X Arabinose 5-phosphate isomerase ASA_3528 ENOG4105C5H ABC transporter ASA_3530 ENOG4105D6S protein involved in catabolism of external DNA ASA_3544 ENOG4108Z6Z Transcriptional regulator ASA_3546 ENOG4105CK7 Sodium proline symporter ASA_3547 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASA_3548 ENOG4105CUY Mechanosensitive ion channel ASA_3550 ENOG4105XEP YhcH YjgK YiaL family protein ASA_3560 ENOG4105C8J )-transporter ASA_3562 ENOG4105C8J )-transporter ASA_3565 ENOG4108K4B hydrolase ASA_3568 ENOG4105EW9 transcriptional regulator AsnC family ASA_3571 ENOG4105K56 Transcriptional regulator ASA_3572 ENOG4108ZHJ Organic hydroperoxide resistance protein ASA_3573 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ASA_3574 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASA_3577 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ASA_3578 ENOG410804X Transcriptional regulator ASA_3580 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase ASA_3581 ENOG4105VI0 Pts system, glucitol sorbitol-specific ASA_3582 ENOG4105DZY Pts system, glucitol sorbitol-specific ASA_3583 ENOG410787A Pts system, glucitol sorbitol-specific ASA_3588 ENOG4108GAE asmA family ASA_3590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASA_3591 ENOG4105DJY efflux transporter, rnd family, mfp subunit ASA_3592 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASA_3593 ENOG4105E0F Histidine kinase ASA_3594 ENOG4105E09 nadh pyrophosphatase ASA_3600 ENOG4107QWG 2-Nitropropane dioxygenase ASA_3606 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase ASA_3610 ENOG4105C1J atp-dependent rna helicase ASA_3612 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) ASA_3615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ASA_3616 ENOG4105DWY Agmatine deiminase ASA_3618 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr ASA_3621 ENOG41060WC Enoyl-CoA hydratase ASA_3622 ENOG4106WH9 Protein of unknown function (DUF2753) ASA_3623 ENOG4105EQK -acetyltransferase ASA_3625 ENOG4107QSI ABC, transporter ASA_3628 ENOG4105VZ9 UPF0235 protein ASA_3629 ENOG4108VIA integral membrane protein ASA_3630 ENOG4105II7 pyrroline-5-carboxylate reductase ASA_3631 ENOG4105DFA alanine racemase domain protein ASA_3632 ENOG4105CZX twitching motility protein ASA_3633 ENOG4105CZX twitching motility protein ASA_3634 ENOG4105D1Q UPF0246 protein ASA_3635 ENOG4105C1J atp-dependent rna helicase ASA_3636 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ASA_3637 ENOG4105CWM branched-chain amino acid transport system II carrier protein ASA_3640 ENOG4105MYN Zinc uptake regulation protein ASA_3641 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASA_3644 ENOG4105K70 DNA-binding protein ASA_3645 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor ASA_3647 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ASA_3650 ENOG4105EAC phosphoserine phosphatase ASA_3652 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASA_3653 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ASA_3654 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ASA_3655 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ASA_3657 ENOG4105D9N nucleoside ASA_3658 ENOG4105EYA deoxyribonuclease ASA_3661 ENOG4105VDT -acetyltransferase ASA_3662 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASA_3663 ENOG4105BZU Histidine kinase ASA_3666 ENOG4107R3N Filamentation induced by cAMP protein fic ASA_3674 ENOG4105XB7 anti-repressor protein ASA_3678 ENOG4105XQ6 frataxin-like protein ASA_3679 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ASA_3680 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ASA_3682 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASA_3683 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ASA_3685 ENOG4105D64 Mechanosensitive ion channel ASA_3687 ENOG4108Z86 Glutamine amidotransferase ASA_3688 ENOG410667J hydrolase ASA_3691 ENOG4105CJ1 ABC, transporter ASA_3693 ENOG4108I62 cina-like protein ASA_3694 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) ASA_3695 ENOG4105CVG Homoserine O-transsuccinylase ASA_3697 ENOG4108YXU transcriptional regulator AsnC family ASA_3698 ENOG4105E0M Sulfatase ASA_3702 ENOG4105KT7 mgtC SapB transporter ASA_3706 ENOG4105EMU Dehydrogenase ASA_3707 ENOG4105DZW Dipeptidase ASA_3710 ENOG4108I6A alcohol dehydrogenase ASA_3712 ENOG4108IQK o-acetylhomoserine ASA_3714 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ASA_3715 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ASA_3719 ENOG4107IFA Lipase (EC 3.1.1.3) ASA_3721 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASA_3722 ENOG4108UB4 uncharacterized protein ygjQ ASA_3723 ENOG4107MM9 BNR Asp-box repeat-containing protein ASA_3725 ENOG4105HMV Fimbrial protein ASA_3727 ENOG4106PG1 outer membrane usher protein ASA_3728 ENOG4108FZ9 Chaperone ASA_3729 ENOG4105NEV Fimbrial ASA_3733 ENOG4105CEY Amp-dependent synthetase and ligase ASA_3734 ENOG4105DNI Converts SHCHC to OSB (By similarity) ASA_3735 ENOG4108IPT Naphthoate synthase ASA_3736 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ASA_3737 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ASA_3738 ENOG4105E4F Isochorismate synthase ASA_3739 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ASA_3744 ENOG4105C1J atp-dependent rna helicase ASA_3745 ENOG4105D9N nucleoside ASA_3746 ENOG4107K5X Membrane-bound metal-dependent hydrolase ASA_3749 ENOG4108UPT UPF0178 protein ASA_3753 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASA_3754 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ASA_3755 ENOG4105E61 Mannitol repressor protein ASA_3756 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ASA_3757 ENOG4105CTS PTS system mannitol-specific ASA_3760 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ASA_3761 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ASA_3762 ENOG4105NNS Autoinducer synthesis protein ASA_3763 ENOG4105VJY transcriptional regulator ASA_3764 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ASA_3765 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ASA_3766 ENOG4108XTF Outer Membrane Lipoprotein ASA_3767 ENOG4108R6G acetyltransferase ASA_3768 ENOG4105VXR cytoplasmic protein ASA_3771 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ASA_3772 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ASA_3773 ENOG4105VEJ Heat shock protein ASA_3774 ENOG4108XKW General secretion pathway protein C ASA_3775 ENOG4105GVR general secretion pathway protein D ASA_3776 ENOG4107QHF type ii secretion system protein e ASA_3777 ENOG4105D7Q type ii secretion system ASA_3778 ENOG4108VAU general secretion pathway protein G ASA_3786 ENOG4108UDW Transcriptional regulator, luxr family ASA_3787 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASA_3788 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 ASA_3789 ENOG4107RK2 ADP-ribose diphosphatase NudE ASA_3790 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ASA_3791 ENOG4105C44 Serine transporter ASA_3792 ENOG4108Z7R Chaperone CsaA ASA_3794 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ASA_3795 ENOG4105C28 cystathionine ASA_3796 ENOG4105CFH Aspartokinase ASA_3799 ENOG41067MG lrgb family ASA_3807 ENOG4108Z66 YbaK ebsC protein ASA_3808 ENOG4107TH8 cina domain protein ASA_3809 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ASA_3811 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ASA_3812 ENOG4105CFH Aspartokinase ASA_3813 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ASA_3818 ENOG41061WM D-Alanyl-D-Alanine ASA_3819 ENOG4106W5V Membrane ASA_3822 ENOG4105MYG DNA polymerase iii, chi subunit ASA_3823 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASA_3824 ENOG4108M8S permease YjgP YjgQ family protein ASA_3825 ENOG4108K5H permease YjgP YjgQ family protein ASA_3854 ENOG4105ED4 portal protein ASA_3870 ENOG4105M7P phage repressor ASA_3871 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASA_3872 ENOG4105DFP Integrase ASA_3874 ENOG4107T0K Adenylate cyclase ASA_3875 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ASA_3876 ENOG41076E6 Uroporphyrinogen-III Synthase ASA_3877 ENOG4105ECF c-methyltransferase ASA_3880 ENOG4105CBT Fructose-1,6-bisphosphatase ASA_3888 ENOG4105N0V mono-oxygenase ydhR ASA_3890 ENOG4108TPP exopolysaccharide synthesis ASA_3891 ENOG4105C44 Serine transporter ASA_3894 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) ASA_3895 ENOG4105EQK -acetyltransferase ASA_3900 ENOG4105D41 biosynthesis protein thiH ASA_3901 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASA_3903 ENOG4105D06 uba thif-type nad fad binding protein ASA_3904 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ASA_3905 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ASA_3909 ENOG4105ETX regulatoR ASA_3911 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASA_3912 ENOG4105C3R Methionine synthase ASA_3913 ENOG4105EEQ Na H antiporter ASA_3917 ENOG4108HU6 Metal dependent phosphohydrolase ASA_3919 ENOG4105F0S class B acid phosphatase ASA_3920 ENOG4107SDU Methyl-accepting chemotaxis ASA_3921 ENOG4107MMM Anti-sigma-factor antagonist ASA_3922 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase ASA_3923 ENOG4105BZU Histidine kinase ASA_3924 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASA_3929 ENOG4105D1U peptidase U62 modulator of DNA gyrase ASA_3932 ENOG4105QD6 exported protein ASA_3933 ENOG4105C03 ribonuclease ASA_3934 ENOG4108Z03 MAF-like protein ASA_3935 ENOG4105VQ7 Rod shape-determining protein MreD ASA_3936 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ASA_3937 ENOG4105DFF Rod shape-determining protein mreb ASA_3943 ENOG4105GVR general secretion pathway protein D ASA_3949 ENOG41062P1 Diguanylate cyclase phosphodiesterase ASA_3950 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ASA_3951 ENOG4105EWV Sodium calcium exchanger membrane region ASA_3952 ENOG4105C84 Histidine ammonia-lyase ASA_3953 ENOG4105CGP Urocanate hydratase ASA_3954 ENOG41088SP formiminoglutamate hydrolase ASA_3955 ENOG4105CI2 imidazolone-5-propionate hydrolase ASA_3956 ENOG4105CZE histidine utilization repressor ASA_3957 ENOG41077A9 carbonic anhydrase ASA_3958 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASA_3959 ENOG4105CRP Part of the ABC transporter FtsEX involved in ASA_3960 ENOG4105CAK Cell division ATP-binding protein ftsE ASA_3961 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ASA_3962 ENOG4106H78 methyltransferase ASA_3965 ENOG4105EJ2 Transcriptional regulator ASA_3967 ENOG4107RZC phospholipase d ASA_3968 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASA_3970 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ASA_3972 ENOG41076UM multiple antibiotic resistance (MarC)-related protein ASA_3973 ENOG4105VVZ metal-binding protein ASA_3979 ENOG4107FS9 Membrane ASA_3983 ENOG4105CUG Oligopeptidase b ASA_3986 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ASA_3987 ENOG4105CKD glutathione-regulated potassium-efflux system protein ASA_3994 ENOG41076HS cation diffusion facilitator family transporter ASA_3997 ENOG4108UUM single-stranded DNA-binding protein ASA_3998 ENOG41086KC Transcriptional regulator ASA_3999 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASA_4001 ENOG4105VEQ Cold shock protein ASA_4003 ENOG4106TD9 Diguanylate cyclase ASA_4004 ENOG4105E0F Histidine kinase ASA_4005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASA_4010 ENOG4105C8Q Methyl-accepting chemotaxis ASA_4012 ENOG4105BZU Histidine kinase ASA_4013 ENOG4108YZA Nitrogen regulatory protein pii ASA_4018 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase ASA_4020 ENOG4107QYX exodeoxyribonuclease v alpha ASA_4021 ENOG4107QKA exodeoxyribonuclease V beta ASA_4022 ENOG4105DSY exodeoxyribonuclease V, gamma ASA_4023 ENOG4108VBZ doxx family ASA_4024 ENOG4105C2I pirin domain protein ASA_4033 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASA_4035 ENOG4105BZU Histidine kinase ASA_4040 ENOG4105CH6 catalase ASA_4046 ENOG4105IPI Membrane ASA_4047 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ASA_4049 ENOG4105VDH Dihydroxyacetone kinase ASA_4050 ENOG4108UTZ Dihydroxyacetone kinase ASA_4051 ENOG4105CMT Dihydroxyacetone kinase ASA_4053 ENOG4105D70 Integrase catalytic subunit ASA_4054 ENOG4105F5W AtP-binding protein ASA_4061 ENOG4108ZT0 50S ribosomal protein l17 ASA_4062 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASA_4063 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ASA_4064 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ASA_4065 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ASA_4066 ENOG41067V7 50S ribosomal protein L36 ASA_4067 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ASA_4068 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ASA_4069 ENOG4105VPB 50S ribosomal protein L30 ASA_4070 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ASA_4071 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ASA_4072 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ASA_4073 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ASA_4074 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASA_4075 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ASA_4076 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ASA_4077 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ASA_4078 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ASA_4079 ENOG41083MP 50s ribosomal protein l29 ASA_4080 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ASA_4081 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ASA_4082 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ASA_4083 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ASA_4084 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ASA_4085 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ASA_4086 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ASA_4087 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ASA_4088 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ASA_4090 ENOG4105E0F Histidine kinase ASA_4091 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASA_4092 ENOG4108RRZ Transcription elongation factor GreB ASA_4094 ENOG4105BZM domain protein ASA_4098 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASA_4099 ENOG4105MJ2 Competence protein ASA_4100 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ASA_4101 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ASA_4102 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ASA_4103 ENOG4107YZP Rhodanese domain protein ASA_4104 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ASA_4105 ENOG41063SB peptidase ASA_4107 ENOG4105DIQ Transcriptional regulator ASA_4108 ENOG4108UHU Aldolase ASA_4109 ENOG4105C01 Dihydroxy-acid dehydratase ASA_4110 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ASA_4111 ENOG4105C6Z Gluconate ASA_4112 ENOG4105JIM Phosphatidylserine synthase ASA_4113 ENOG4105CB5 ATP-dependent DNA helicase recG ASA_4115 ENOG4105SUU thioesterase domain ASA_4118 ENOG4107S2Z UPF0761 membrane protein ASA_4120 ENOG4105C5F glutamine synthetase ASA_4122 ENOG4105CUX Signal transduction histidine kinase ASA_4123 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASA_4124 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASA_4125 ENOG4105D4P Coproporphyrinogen iii oxidase ASA_4126 ENOG4105XCT Protein of unknown function (DUF2489) ASA_4127 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) ASA_4128 ENOG4106RE7 Cytochrome ASA_4129 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ASA_4131 ENOG4105SG3 Protein of unknown function (DUF1488) ASA_4132 ENOG4105E2X shikimate dehydrogenase ASA_4133 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ASA_4134 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASA_4136 ENOG4108WI1 Dna topoisomerase ASA_4137 ENOG4108RPN Protein smg homolog ASA_4138 ENOG4105C79 DNA protecting protein DprA ASA_4139 ENOG4108WZM domain protein ASA_4140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASA_4141 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASA_4142 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASA_4143 ENOG4105C1A potassium transporter peripheral membrane ASA_4144 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASA_4145 ENOG4105CGY Dna recombination protein ASA_4149 ENOG4108TFM Kinase, PfkB family ASA_4150 ENOG4105DCF alanine dehydrogenase ASA_4151 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASA_4152 ENOG4105C26 Dehydrogenase ASA_4155 ENOG4105C26 Dehydrogenase ASA_4157 ENOG4105FR1 rard protein ASA_4158 ENOG4105ECQ AraC Family Transcriptional Regulator ASA_4160 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ASA_4161 ENOG4105CUC YeeE YedE family protein ASA_4162 ENOG410829K Lysine exporter protein (Lyse ygga) ASA_4163 ENOG4105EJC lysr family transcriptional regulator ASA_4167 ENOG4105K3G Periplasmic Protein ASA_4174 ENOG4105C4R Atp-dependent dna helicase ASA_4176 ENOG4108JQ9 ABC transporter ASA_4177 ENOG4105UIB (ABC) transporter ASA_4179 ENOG4105CC0 LysR family Transcriptional regulator ASA_4181 ENOG4105C4W S-formylglutathione hydrolase ASA_4183 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process ASA_4184 ENOG4105DHU Bile acid ASA_4193 ENOG4108Z0R Transferase ASA_4194 ENOG4105C2M dna polymerase I ASA_4195 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ASA_4196 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ASA_4198 ENOG4105D7W serine acetyltransferase ASA_4200 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASA_4201 ENOG4105E0F Histidine kinase ASA_4202 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ASA_4206 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ASA_4207 ENOG4105E55 glycerol-3-phosphate acyltransferase ASA_4208 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ASA_4209 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ASA_4210 ENOG4105X6C Flagellar basal body-associated protein FliL ASA_4215 ENOG4105DIQ Transcriptional regulator ASA_4216 ENOG4106ETB IIa component ASA_4219 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ASA_4220 ENOG4105XA0 heptosyltransferase ii ASA_4221 ENOG4106WTF Glycosyl transferase, family 2 ASA_4222 ENOG4105M5K heptosyltransferase ASA_4223 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ASA_4224 ENOG4108MJ5 VirK protein ASA_4225 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ASA_4227 ENOG4105W0E 50S ribosomal protein L33 ASA_4228 ENOG4105KDC 50s ribosomal protein l28 ASA_4229 ENOG4105W5Q DNA repair protein (RadC ASA_4230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ASA_4231 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ASA_4232 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ASA_4233 ENOG4105D64 Mechanosensitive ion channel ASA_4235 ENOG4107QP8 phosphohexose isomerase ASA_4236 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ASA_4237 ENOG4105EMY transcriptional regulator ASA_4240 ENOG4105CD5 CoA-binding domain protein ASA_4245 ENOG4108RR8 protoporphyrinogen oxidase ASA_4246 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASA_4247 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ASA_4248 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) ASA_4249 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASA_4250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASA_4251 ENOG4105CHU acetyl-coa acetyltransferase ASA_4252 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASA_4253 ENOG4105E0F Histidine kinase ASA_4256 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ASA_4257 ENOG4105M4H endoribonuclease L-psp ASA_4258 ENOG4108ZG0 Ompa motb domain protein ASA_4259 ENOG4108R3E Dna-3-methyladenine glycosylase i ASA_4260 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit ASA_4261 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ASA_4262 ENOG41090VV Protein of unknown function (DUF2846) ASA_4263 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASA_4265 ENOG4105BZU Histidine kinase ASA_4266 ENOG41072JS exoenzyme T ASA_4268 ENOG4105CIC tryptophan-specific transport protein ASA_4269 ENOG4105HEE Binding Domain protein ASA_4271 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase ASA_4272 ENOG4105CNW domain protein ASA_4273 ENOG4108JUA Transcriptional regulator ASA_4274 ENOG4105FDP GntR family transcriptional regulator ASA_4276 ENOG4105CI1 PTS System ASA_4277 ENOG4105F8D glycoside hydrolase family 4 ASA_4278 ENOG4105ETE Transcriptional regulator (LacI family ASA_4279 ENOG4105CP9 extracellular ligand-binding receptor ASA_4280 ENOG4105C32 Amino acid ABC transporter (Permease) ASA_4281 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ASA_4282 ENOG4105C0Z ABC transporter ASA_4283 ENOG4108IV0 ABC, transporter ASA_4286 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) ASA_4289 ENOG4105W0Z cytoplasmic protein ASA_4290 ENOG4107QK7 reductase ASA_4291 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ASA_4293 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ASA_4294 ENOG4105K63 Thioredoxin ASA_4295 ENOG4105C1J atp-dependent rna helicase ASA_4296 ENOG4105C9X ppx gppa phosphatase ASA_4298 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ASA_4300 ENOG4105BZU Histidine kinase ASA_4301 ENOG4105DGW oligopeptidase A ASA_4302 ENOG4105D52 delta-aminolevulinic acid dehydratase ASA_4303 ENOG4105F8V Hydrolase, tatD family ASA_4304 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ASA_4305 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ASA_4306 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ASA_4307 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ASA_4308 ENOG4105JC1 sterol-binding domain protein ASA_4309 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASA_4310 ENOG4105WMR Protein CrcB homolog ASA_4319 ENOG410822N TonB family ASA_4320 ENOG4109015 Biopolymer transport protein exbD tolR ASA_4324 ENOG4105VJY transcriptional regulator ASA_4326 ENOG4105CVR type I restriction-modification system ASA_4329 ENOG4105F5W AtP-binding protein ASA_4330 ENOG4105D70 Integrase catalytic subunit ASA_4342 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ASA_4343 ENOG410804X Transcriptional regulator ASA_4344 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASA_4345 ENOG4105EB3 Histidine kinase ASA_4347 ENOG4105CT7 inner membrane cred family protein ASA_4348 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASA_4349 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ASA_4350 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ASA_4351 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ASA_4352 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ASA_4353 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASA_4354 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASA_4355 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASA_4356 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) ASA_4357 ENOG410684E atp synthase ASA_4358 ENOG4105FA0 parb-like partition protein ASA_4359 ENOG4107QJE Chromosome Partitioning Protein ASA_4360 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ASA_4361 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ASA_4362 ENOG4105QTB Flavodoxin ASA_4363 ENOG4105E0K tonB-dependent siderophore receptor ASA_4364 ENOG4105IBP Cyclic peptide transporter ASA_4365 ENOG4105E0A ABC, transporter ASA_4366 ENOG4105J76 Periplasmic binding protein ASA_4367 ENOG4105S6R Iron-hydroxamate transporter permease subunit ASA_4370 ENOG4108IPW abc transporter atp-binding protein ASA_4376 ENOG4105CEY Amp-dependent synthetase and ligase ASA_4378 ENOG4105C0W non-ribosomal peptide synthetase ASA_4381 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ASA_4382 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASA_4383 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ASA_4384 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ASA_4385 ENOG4105VG0 50S ribosomal protein l34 ASA_4386 ENOG4105CDA abc transporter atp-binding protein ASA_4387 ENOG4105E5Q amino acid AbC transporter ASA_4388 ENOG4105EAB amino acid AbC transporter ASA_P4G001 ENOG4105D70 Integrase catalytic subunit ASA_P4G002 ENOG4105F5W AtP-binding protein ASA_P4G025 ENOG4107QJE Chromosome Partitioning Protein ASA_P4G030 ENOG4105K70 DNA-binding protein ASA_P4G031 ENOG4105KK6 nuclease ASA_P4G040 ENOG4105DH7 May be involved in recombination (By similarity) ASA_P4G072 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASA_P4G080 ENOG4105CS6 Rhs element vgr protein ASA_P4G085 ENOG4105D70 Integrase catalytic subunit ASA_P4G087 ENOG4105W1Y Transcriptional regulator ASA_P4G088 ENOG4108VSE mercuric transport protein ASA_P4G094 ENOG4105BZU Histidine kinase ASA_P4G110 ENOG4105CAF HipA N-terminal domain protein ASA_P4G111 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein ASA_P4G112 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASA_P4G141 ENOG4105XPH Ferredoxin ASA_P4G151 ENOG410600T transposase ASA_P4G164 ENOG410600T transposase ASA_P4G171 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASA_P4G174 ENOG4105D85 methylase ASA_P4G175 ENOG4105F6A helicase ASA_P4G176 ENOG4105ECI YeeC-like protein ASA_P5G004 ENOG4107SKI cobyrinic Acid a,c-diamide synthase ASA_P5G006 ENOG4105D5G Transposase ASA_P5G011 ENOG4105K8R UPF0145 protein ASA_P5G021 ENOG4107QJE Chromosome Partitioning Protein ASA_P5G044 ENOG4105D5G Transposase ASA_P5G047 ENOG4105EQR Transposase IS116 IS110 IS902 ASA_P5G054 ENOG41066XE Type III export protein ASA_P5G060 ENOG4108KB1 transcriptional regulator, arac family ASA_P5G063 ENOG4106V6P Exoenzyme S synthesis protein C ASA_P5G088 ENOG4107U2T alpha beta ASA_P5G090 ENOG4105D5G Transposase ASA_P5G091 ENOG4105F5W AtP-binding protein ASA_P5G092 ENOG4105D70 Integrase catalytic subunit ASA_P5G122 ENOG4105EQR Transposase IS116 IS110 IS902 ASA_P5G123 ENOG4106RHG Yeca family ASA_P5G127 ENOG4108C33 Resolvase ASA_P5G141 ENOG4105W5Q DNA repair protein (RadC ASA_P5G148 ENOG4105D70 Integrase catalytic subunit ASA_P5G149 ENOG4105F5W AtP-binding protein ASA_P5G151 ENOG4107635 Hok Gef family protein ASA_P5G157 ENOG4105DIJ Phosphoethanolamine transferase ASA_P5G158 ENOG4105DIJ Phosphoethanolamine transferase ASA_P5G160 ENOG4108C33 Resolvase