locus-tag	class	description
ASA_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASA_0002	COG0592	DNA-directed DNA polymerase activity
ASA_0004	COG0187	DNA topoisomerase II activity
ASA_0007	COG2378	regulation of single-species biofilm formation
ASA_0008	COG0071	Belongs to the small heat shock protein (HSP20) family
ASA_0009	COG0071	Belongs to the small heat shock protein (HSP20) family
ASA_0012	COG3977	Valine--pyruvate aminotransferase
ASA_0016	COG0745	RESPONSE REGULATOR receiver
ASA_0017	COG2205	protein histidine kinase activity
ASA_0021	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASA_0022	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_0022	COG4191	Histidine kinase
ASA_0023	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASA_0024	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_0025	COG1309	transcriptional regulator
ASA_0031	COG0561	phosphatase activity
ASA_0032	COG2267	carboxylic ester hydrolase activity
ASA_0033	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASA_0034	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASA_0035	COG1758	RNA polymerase activity
ASA_0036	COG0194	GDP metabolic process
ASA_0037	COG0859	PFAM glycosyl transferase family 9
ASA_0038	COG3642	lipopolysaccharide core region biosynthetic process
ASA_0046	COG0589	response to stress
ASA_0047	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASA_0049	COG1528	Iron-storage protein
ASA_0050	COG2081	HI0933 family
ASA_0060	COG4584	PFAM Integrase catalytic
ASA_0061	COG1484	DNA-dependent DNA replication
ASA_0063	COG2197	response regulator
ASA_0066	COG2801	Transposase and inactivated derivatives
ASA_0068	COG3275	phosphorelay sensor kinase activity
ASA_0069	COG3279	Response regulator of the LytR AlgR family
ASA_0070	COG2223	nitrite transmembrane transporter activity
ASA_0071	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ASA_0072	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ASA_0075	COG0583	DNA-binding transcription factor activity
ASA_0076	COG4206	TonB-dependent receptor
ASA_0077	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASA_0084	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ASA_0085	COG2166	iron-sulfur cluster assembly
ASA_0086	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASA_0087	COG0210	DNA helicase
ASA_0090	COG1063	alcohol dehydrogenase
ASA_0093	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASA_0094	COG0438	transferase activity, transferring glycosyl groups
ASA_0100	COG1561	YicC-like family, N-terminal region
ASA_0102	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASA_0105	COG3706	GGDEF domain
ASA_0105	COG2203	Gaf domain
ASA_0105	COG5001	Diguanylate cyclase
ASA_0105	COG4251	negative regulation of phosphorylation
ASA_0106	COG3084	Protein conserved in bacteria
ASA_0108	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ASA_0109	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASA_0110	COG3639	organic phosphonate transmembrane transporter activity
ASA_0111	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ASA_0112	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ASA_0114	COG1335	isochorismatase
ASA_0116	COG1683	Conserved Protein
ASA_0117	COG0204	Acyl-transferase
ASA_0118	COG0606	chelatase, subunit chli
ASA_0120	COG3978	acetolactate synthase activity
ASA_0121	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASA_0122	COG0129	dihydroxy-acid dehydratase activity
ASA_0126	COG1309	transcriptional regulator
ASA_0128	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ASA_0129	COG0254	rRNA binding
ASA_0130	COG0702	epimerase
ASA_0131	COG0281	malic enzyme
ASA_0133	COG2205	protein histidine kinase activity
ASA_0134	COG0745	RESPONSE REGULATOR receiver
ASA_0135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASA_0148	COG2089	acid synthase
ASA_0150	COG1083	cytidylyl-transferase
ASA_0154	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_0157	COG1215	transferase activity, transferring glycosyl groups
ASA_0158	COG1442	glycosyl transferase family 8
ASA_0163	COG1086	Polysaccharide biosynthesis protein
ASA_0164	COG0366	Alpha amylase catalytic
ASA_0167	COG0443	Heat shock 70 kDa protein
ASA_0168	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASA_0169	COG3045	CreA protein
ASA_0171	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASA_0172	COG0174	glutamine synthetase
ASA_0176	COG3842	ATPase activity
ASA_0177	COG1176	ABC-type spermidine putrescine transport system, permease component I
ASA_0178	COG1177	transmembrane transport
ASA_0179	COG2258	MOSC domain
ASA_0182	COG2050	protein possibly involved in aromatic compounds catabolism
ASA_0183	COG0514	ATP-dependent DNA helicase (RecQ)
ASA_0185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ASA_0187	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ASA_0189	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASA_0191	COG2239	Acts as a magnesium transporter
ASA_0192	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASA_0192	COG1648	precorrin-2 dehydrogenase activity
ASA_0193	COG2116	formate transmembrane transporter activity
ASA_0194	COG2146	nitrite reductase [NAD(P)H] activity
ASA_0196	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASA_0199	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASA_0200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ASA_0202	COG0018	arginyl-trna synthetase
ASA_0204	COG1595	DNA-templated transcription, initiation
ASA_0206	COG1968	undecaprenyl-diphosphatase activity
ASA_0207	COG0667	Aldo Keto reductase
ASA_0208	COG2017	converts alpha-aldose to the beta-anomer
ASA_0209	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASA_0211	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASA_0212	COG1609	Transcriptional regulator
ASA_0224	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASA_0225	COG1288	antiporter activity
ASA_0227	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ASA_0228	COG0540	Belongs to the ATCase OTCase family
ASA_0231	COG0688	phosphatidylethanolamine metabolic process
ASA_0233	COG3040	lipid binding
ASA_0234	COG2207	Transcriptional regulator
ASA_0235	COG1979	alcohol dehydrogenase
ASA_0236	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ASA_0237	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ASA_0239	COG2964	Protein conserved in bacteria
ASA_0240	COG3681	Belongs to the UPF0597 family
ASA_0242	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASA_0243	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASA_0244	COG0564	pseudouridine synthase activity
ASA_0246	COG0542	response to heat
ASA_0247	COG2502	aspartate--ammonia ligase
ASA_0248	COG1522	sequence-specific DNA binding
ASA_0251	COG0516	GMP reductase activity
ASA_0251	COG0517	IMP dehydrogenase activity
ASA_0252	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_0254	COG2205	protein histidine kinase activity
ASA_0256	COG2204	response regulator
ASA_0258	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASA_0259	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ASA_0262	COG0745	RESPONSE REGULATOR receiver
ASA_0263	COG2205	protein histidine kinase activity
ASA_0265	COG0243	molybdopterin cofactor binding
ASA_0266	COG3005	denitrification pathway
ASA_0267	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASA_0268	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASA_0269	COG0569	domain protein
ASA_0270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASA_0275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASA_0277	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASA_0278	COG0250	Participates in transcription elongation, termination and antitermination
ASA_0279	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASA_0280	COG0081	regulation of translation
ASA_0281	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASA_0282	COG0222	ribosome binding
ASA_0283	COG0085	RNA polymerase activity
ASA_0284	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASA_0285	COG2964	Protein conserved in bacteria
ASA_0288	COG2923	Belongs to the DsrF TusC family
ASA_0289	COG2168	tRNA wobble position uridine thiolation
ASA_0290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASA_0291	COG0049	tRNA binding
ASA_0292	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASA_0293	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASA_0294	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASA_0299	COG2926	Belongs to the UPF0265 family
ASA_0301	COG3028	Belongs to the UPF0307 family
ASA_0302	COG0312	modulator of DNA gyrase
ASA_0303	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASA_0304	COG5007	Belongs to the BolA IbaG family
ASA_0306	COG2854	intermembrane phospholipid transfer
ASA_0307	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASA_0308	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASA_0309	COG1127	ABC transporter
ASA_0310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASA_0310	COG0517	IMP dehydrogenase activity
ASA_0311	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ASA_0312	COG3117	lipopolysaccharide transmembrane transporter activity
ASA_0313	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ASA_0314	COG1137	ATPase activity
ASA_0315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ASA_0317	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_0318	COG1660	Displays ATPase and GTPase activities
ASA_0319	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_0323	COG3964	amidohydrolase
ASA_0329	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASA_0330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASA_0332	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ASA_0333	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASA_0334	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASA_0335	COG0723	plastoquinol--plastocyanin reductase activity
ASA_0336	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASA_0337	COG2857	Cytochrome c1
ASA_0338	COG0625	glutathione transferase activity
ASA_0339	COG2969	positive regulation of protein catabolic process
ASA_0340	COG2823	Periplasmic or secreted lipoprotein
ASA_0341	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASA_0342	COG0792	nuclease activity
ASA_0343	COG3107	peptidoglycan biosynthetic process
ASA_0344	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ASA_0349	COG1987	bacterial-type flagellum assembly
ASA_0353	COG2204	response regulator
ASA_0354	COG1677	Flagellar hook-basal body complex protein FliE
ASA_0356	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASA_0361	COG2747	anti-sigma28 factor FlgM
ASA_0363	COG1815	bacterial-type flagellum-dependent cell motility
ASA_0364	COG1558	bacterial-type flagellum-dependent cell motility
ASA_0366	COG1749	Flagellar hook protein flgE
ASA_0367	COG4786	Flagellar basal body rod
ASA_0368	COG4786	Flagellar basal body rod
ASA_0369	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASA_0370	COG1706	bacterial-type flagellum-dependent cell motility
ASA_0372	COG1256	bacterial-type flagellum assembly
ASA_0377	COG2801	Transposase and inactivated derivatives
ASA_0379	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ASA_0384	COG1191	sigma factor activity
ASA_0385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASA_0386	COG1360	Flagellar Motor Protein
ASA_0387	COG1388	LysM domain
ASA_0387	COG0741	lytic transglycosylase activity
ASA_0389	COG2001	Belongs to the MraZ family
ASA_0390	COG0275	rRNA processing
ASA_0391	COG3116	cell division
ASA_0392	COG0768	penicillin binding
ASA_0394	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASA_0395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASA_0396	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASA_0397	COG0772	Belongs to the SEDS family
ASA_0398	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASA_0399	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASA_0400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ASA_0401	COG0849	cell division
ASA_0402	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASA_0403	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ASA_0405	COG0653	protein targeting
ASA_0407	COG0494	nUDIX hydrolase
ASA_0408	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ASA_0409	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ASA_0411	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ASA_0413	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASA_0418	COG2186	Transcriptional regulator
ASA_0419	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASA_0420	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASA_0421	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASA_0422	COG5001	Diguanylate cyclase
ASA_0422	COG3447	MASE1 domain protein
ASA_0422	COG5002	protein histidine kinase activity
ASA_0424	COG0840	transmembrane signaling receptor activity
ASA_0427	COG1049	propionate catabolic process, 2-methylcitrate cycle
ASA_0428	COG2200	EAL domain
ASA_0429	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_0430	COG0583	DNA-binding transcription factor activity
ASA_0432	COG1280	lysine exporter protein (LysE YggA)
ASA_0434	COG0523	cobalamin synthesis protein
ASA_0435	COG0477	Major facilitator Superfamily
ASA_0438	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASA_0439	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ASA_0452	COG2801	Transposase and inactivated derivatives
ASA_0462	COG0835	chemotaxis
ASA_0462	COG0784	Response regulator, receiver
ASA_0463	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_0464	COG1444	tRNA N-acetyltransferase activity
ASA_0469	COG1803	Methylglyoxal synthase
ASA_0472	COG0252	asparaginase activity
ASA_0474	COG1609	Transcriptional regulator
ASA_0476	COG1940	carbohydrate kinase activity
ASA_0477	COG1447	Phosphotransferase system cellobiose-specific component IIA
ASA_0478	COG2723	6-phospho-beta-galactosidase activity
ASA_0479	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ASA_0480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ASA_0481	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ASA_0485	COG0366	Alpha amylase catalytic
ASA_0486	COG0110	maltose O-acetyltransferase activity
ASA_0488	COG1757	Na H antiporter
ASA_0496	COG0297	glycogen (starch) synthase activity
ASA_0497	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASA_0498	COG2813	Specifically methylates the guanine in position
ASA_0499	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASA_0500	COG2203	Gaf domain
ASA_0500	COG5001	Diguanylate cyclase
ASA_0500	COG4251	negative regulation of phosphorylation
ASA_0500	COG3706	GGDEF domain
ASA_0502	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASA_0504	COG2995	paraquat-inducible protein a
ASA_0505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASA_0505	COG3008	intermembrane lipid transfer
ASA_0506	COG3009	Protein conserved in bacteria
ASA_0509	COG3240	lipase activity
ASA_0510	COG3111	PFAM Bacterial OB fold (BOF) protein
ASA_0512	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ASA_0513	COG1194	a g-specific adenine glycosylase
ASA_0515	COG3267	Type II secretory pathway component ExeA
ASA_0515	COG3409	Peptidoglycan-binding domain 1 protein
ASA_0516	COG0617	tRNA 3'-terminal CCA addition
ASA_0517	COG0306	phosphate transporter
ASA_0518	COG1392	Phosphate transport regulator
ASA_0521	COG1560	Kdo2-lipid A biosynthetic process
ASA_0522	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASA_0522	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASA_0523	COG1538	Outer membrane efflux protein
ASA_0525	COG0494	nUDIX hydrolase
ASA_0526	COG3151	Protein conserved in bacteria
ASA_0528	COG3150	esterase
ASA_0529	COG1051	belongs to the nudix hydrolase family
ASA_0531	COG0187	DNA topoisomerase II activity
ASA_0541	COG2259	Doxx family
ASA_0542	COG3118	belongs to the thioredoxin family
ASA_0546	COG0204	Acyl-transferase
ASA_0547	COG1842	Phage shock protein A
ASA_0550	COG2827	Endonuclease containing a URI domain
ASA_0552	COG2962	Rard protein
ASA_0553	COG1573	uracil-dna glycosylase
ASA_0555	COG0583	DNA-binding transcription factor activity
ASA_0556	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASA_0557	COG1121	(ABC) transporter
ASA_0558	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ASA_0562	COG0739	heme binding
ASA_0564	COG3068	Protein conserved in bacteria
ASA_0568	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASA_0572	COG0798	PFAM Bile acid sodium symporter
ASA_0573	COG1393	Belongs to the ArsC family
ASA_0574	COG2072	flavoprotein involved in K transport
ASA_0576	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASA_0578	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASA_0579	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASA_0581	COG0137	argininosuccinate synthase activity
ASA_0582	COG0165	Argininosuccinate lyase
ASA_0583	COG0583	DNA-binding transcription factor activity
ASA_0585	COG1942	4-Oxalocrotonate Tautomerase
ASA_0591	COG0110	maltose O-acetyltransferase activity
ASA_0592	COG3174	membrane
ASA_0593	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ASA_0595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ASA_0596	COG4208	sulfate ABC transporter
ASA_0597	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASA_0598	COG0583	DNA-binding transcription factor activity
ASA_0599	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASA_0600	COG0765	amino acid transport
ASA_0602	COG1126	abc transporter atp-binding protein
ASA_0603	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_0604	COG3397	chitin binding
ASA_0605	COG0840	transmembrane signaling receptor activity
ASA_0614	COG1215	transferase activity, transferring glycosyl groups
ASA_0620	COG1328	CTP reductase activity
ASA_0621	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASA_0624	COG1448	Aminotransferase
ASA_0632	COG0513	Belongs to the DEAD box helicase family
ASA_0635	COG3568	Endonuclease Exonuclease Phosphatase
ASA_0636	COG0840	transmembrane signaling receptor activity
ASA_0639	COG3112	Uncharacterised protein family (UPF0231)
ASA_0640	COG3835	regulator
ASA_0641	COG2610	gluconate transmembrane transporter activity
ASA_0641	COG2610	gluconate transmembrane transporter activity
ASA_0642	COG1929	Belongs to the glycerate kinase type-1 family
ASA_0646	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASA_0647	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASA_0649	COG0347	Belongs to the P(II) protein family
ASA_0650	COG1840	ABC-type Fe3 transport system, periplasmic component
ASA_0652	COG3842	ATPase activity
ASA_0653	COG2837	iron assimilation
ASA_0654	COG1438	arginine binding
ASA_0655	COG1126	abc transporter atp-binding protein
ASA_0656	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_0657	COG4215	(ABC) transporter
ASA_0658	COG4160	amino acid transport
ASA_0659	COG0039	L-malate dehydrogenase activity
ASA_0660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ASA_0661	COG1017	nitric oxide dioxygenase activity
ASA_0661	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASA_0662	COG1959	2 iron, 2 sulfur cluster binding
ASA_0663	COG4536	flavin adenine dinucleotide binding
ASA_0664	COG4137	Cytochrome C assembly protein
ASA_0665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASA_0666	COG0228	four-way junction DNA binding
ASA_0667	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASA_0668	COG0336	Belongs to the RNA methyltransferase TrmD family
ASA_0669	COG0335	large ribosomal subunit rRNA binding
ASA_0671	COG3066	DNA modification
ASA_0673	COG1051	belongs to the nudix hydrolase family
ASA_0675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASA_0676	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASA_0677	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASA_0679	COG0583	DNA-binding transcription factor activity
ASA_0680	COG0640	Transcriptional regulator
ASA_0681	COG0268	Binds directly to 16S ribosomal RNA
ASA_0682	COG0728	peptidoglycan biosynthetic process
ASA_0683	COG0196	riboflavin kinase activity
ASA_0684	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASA_0685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ASA_0686	COG1047	Peptidyl-prolyl cis-trans
ASA_0687	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASA_0688	COG4968	Prepilin-type N-terminal cleavage methylation domain
ASA_0694	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASA_0694	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASA_0697	COG1854	S-ribosylhomocysteine lyase activity
ASA_0698	COG3706	GGDEF domain
ASA_0699	COG0557	exoribonuclease II activity
ASA_0700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASA_0702	COG2153	protein acetylation
ASA_0706	COG1914	H( )-stimulated, divalent metal cation uptake system
ASA_0707	COG0360	Binds together with S18 to 16S ribosomal RNA
ASA_0708	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASA_0709	COG0359	binds to the 23S rRNA
ASA_0714	COG1064	alcohol dehydrogenase
ASA_0715	COG1238	metal cluster binding
ASA_0716	COG0612	Peptidase, M16
ASA_0717	COG2918	glutathione biosynthetic process
ASA_0719	COG1022	Amp-dependent synthetase and ligase
ASA_0721	COG0456	acetyltransferase
ASA_0723	COG0714	Associated with various cellular activities
ASA_0728	COG3706	GGDEF domain
ASA_0728	COG0745	RESPONSE REGULATOR receiver
ASA_0729	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ASA_0731	COG1902	pentaerythritol trinitrate reductase activity
ASA_0733	COG0442	prolyl-tRNA aminoacylation
ASA_0734	COG0840	transmembrane signaling receptor activity
ASA_0735	COG0632	four-way junction helicase activity
ASA_0736	COG2255	four-way junction helicase activity
ASA_0737	COG1271	oxidase subunit
ASA_0738	COG1294	oxidase, subunit
ASA_0739	COG4890	Cyd operon protein YbgT
ASA_0740	COG3790	cyd operon protein YbgE
ASA_0741	COG0824	Thioesterase
ASA_0742	COG0811	peptide transport
ASA_0745	COG0823	Involved in the tonB-independent uptake of proteins
ASA_0746	COG2885	chlorophyll binding
ASA_0747	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ASA_0756	COG0840	transmembrane signaling receptor activity
ASA_0757	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASA_0758	COG0676	glucose-6-phosphate 1-epimerase activity
ASA_0759	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASA_0760	COG1640	4-alpha-glucanotransferase
ASA_0761	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASA_0765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASA_0766	COG4991	sh3 domain protein
ASA_0767	COG0506	proline dehydrogenase activity
ASA_0767	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ASA_0767	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ASA_0769	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASA_0770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASA_0771	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASA_0772	COG0163	prenyltransferase activity
ASA_0775	COG1131	(ABC) transporter
ASA_0776	COG0842	Transport permease protein
ASA_0778	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASA_0779	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASA_0780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASA_0781	COG0617	tRNA 3'-terminal CCA addition
ASA_0782	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASA_0783	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASA_0784	COG1489	DNA binding
ASA_0786	COG1643	Atp-dependent helicase
ASA_0787	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASA_0788	COG0346	lactoylglutathione lyase activity
ASA_0790	COG2076	Multidrug Resistance protein
ASA_0791	COG0583	DNA-binding transcription factor activity
ASA_0792	COG3437	response regulator, receiver
ASA_0792	COG0784	Response regulator, receiver
ASA_0794	COG0671	phosphoesterase, PA-phosphatase related
ASA_0797	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASA_0798	COG0038	chloride channel
ASA_0800	COG0316	Belongs to the HesB IscA family
ASA_0806	COG1280	lysine exporter protein (LysE YggA)
ASA_0807	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ASA_0810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_0816	COG0745	RESPONSE REGULATOR receiver
ASA_0817	COG3104	oligopeptide transport
ASA_0818	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ASA_0819	COG1555	photosystem II stabilization
ASA_0821	COG2350	Protein conserved in bacteria
ASA_0822	COG2917	probably involved in intracellular septation
ASA_0823	COG0076	glutamate decarboxylase activity
ASA_0824	COG1272	protein, Hemolysin III
ASA_0825	COG2985	domain, Protein
ASA_0825	COG0569	domain protein
ASA_0827	COG0784	Response regulator, receiver
ASA_0827	COG0835	chemotaxis
ASA_0828	COG2755	lipolytic protein G-D-S-L family
ASA_0829	COG4181	ATPase activity
ASA_0830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ASA_0831	COG1090	epimerase
ASA_0832	COG2200	EAL domain
ASA_0835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASA_0836	COG3171	Protein conserved in bacteria
ASA_0837	COG2066	Belongs to the glutaminase family
ASA_0838	COG2897	thiosulfate sulfurtransferase activity
ASA_0840	COG1132	(ABC) transporter
ASA_0843	COG1012	belongs to the aldehyde dehydrogenase family
ASA_0849	COG4412	M6 family metalloprotease domain protein
ASA_0849	COG3291	Pkd domain containing protein
ASA_0850	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ASA_0851	COG5001	Diguanylate cyclase
ASA_0851	COG3300	MHYT domain
ASA_0855	COG4628	conserved protein (DUF2132)
ASA_0856	COG0688	phosphatidylethanolamine metabolic process
ASA_0858	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASA_0864	COG1278	Cold shock
ASA_0866	COG0840	transmembrane signaling receptor activity
ASA_0867	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASA_0876	COG0848	biopolymer transport protein
ASA_0877	COG0811	peptide transport
ASA_0878	COG0811	peptide transport
ASA_0880	COG4206	TonB-dependent receptor
ASA_0882	COG4239	(ABC) transporter, permease
ASA_0883	COG0747	negative chemotaxis
ASA_0884	COG0444	Belongs to the ABC transporter superfamily
ASA_0885	COG4608	Belongs to the ABC transporter superfamily
ASA_0887	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASA_0890	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASA_0893	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASA_0894	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASA_0900	COG1522	sequence-specific DNA binding
ASA_0900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASA_0901	COG2313	pseudouridylate synthase activity
ASA_0903	COG1858	cytochrome C peroxidase
ASA_0910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASA_0911	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASA_0913	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_0916	COG2986	histidine ammonia-lyase
ASA_0922	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASA_0924	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_0925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASA_0927	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASA_0929	COG2966	Psort location CytoplasmicMembrane, score
ASA_0931	COG3610	response to peptide
ASA_0933	COG4175	Glycine betaine
ASA_0934	COG4176	ABC-type proline glycine betaine transport system permease component
ASA_0935	COG2113	Glycine betaine
ASA_0936	COG0175	sulfate reduction
ASA_0939	COG0384	phenazine biosynthesis protein PhzF
ASA_0940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASA_0943	COG0786	glutamate:sodium symporter activity
ASA_0944	COG0252	asparaginase activity
ASA_0945	COG3139	Protein of unknown function (DUF1315)
ASA_0949	COG0616	signal peptide processing
ASA_0950	COG1902	pentaerythritol trinitrate reductase activity
ASA_0950	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASA_0951	COG0778	Nitroreductase
ASA_0955	COG4302	ethanolamine ammonia-lyase activity
ASA_0956	COG4303	Ethanolamine ammonia lyase large subunit
ASA_0958	COG2264	protein methyltransferase activity
ASA_0959	COG0604	alcohol dehydrogenase
ASA_0960	COG0583	DNA-binding transcription factor activity
ASA_0961	COG1263	PTS System
ASA_0961	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASA_0961	COG2190	(PTS) system
ASA_0962	COG4145	pantothenate transmembrane transporter activity
ASA_0963	COG3924	membrane
ASA_0964	COG0439	Biotin carboxylase
ASA_0965	COG0511	ligase activity, forming carbon-carbon bonds
ASA_0966	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASA_0967	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASA_0973	COG3381	protein complex oligomerization
ASA_0975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASA_0978	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASA_0979	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASA_0979	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASA_0982	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASA_0983	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASA_0984	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASA_0985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ASA_0990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASA_0991	COG0142	geranyltranstransferase activity
ASA_0992	COG1722	exodeoxyribonuclease VII activity
ASA_0993	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASA_0997	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASA_0999	COG1534	Rna-binding protein
ASA_1000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ASA_1001	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASA_1002	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASA_1003	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASA_1004	COG0149	triose-phosphate isomerase activity
ASA_1005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASA_1008	COG0779	Required for maturation of 30S ribosomal subunits
ASA_1009	COG0195	Participates in both transcription termination and antitermination
ASA_1010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASA_1011	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASA_1012	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASA_1013	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASA_1014	COG1185	polyribonucleotide nucleotidyltransferase activity
ASA_1016	COG3706	GGDEF domain
ASA_1017	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ASA_1018	COG1422	Protein of unknown function (DUF1090)
ASA_1029	COG0312	modulator of DNA gyrase
ASA_1031	COG0716	FMN binding
ASA_1032	COG4974	Belongs to the 'phage' integrase family
ASA_1033	COG3706	GGDEF domain
ASA_1034	COG1970	mechanosensitive ion channel activity
ASA_1036	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ASA_1040	COG3545	Serine hydrolase
ASA_1047	COG4584	PFAM Integrase catalytic
ASA_1048	COG1484	DNA-dependent DNA replication
ASA_1054	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASA_1056	COG0321	lipoyl(octanoyl) transferase activity
ASA_1057	COG2921	Belongs to the UPF0250 family
ASA_1058	COG1686	Belongs to the peptidase S11 family
ASA_1059	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASA_1061	COG0772	Belongs to the SEDS family
ASA_1062	COG0768	penicillin binding
ASA_1063	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ASA_1064	COG0799	negative regulation of ribosome biogenesis
ASA_1065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASA_1068	COG0495	leucyl-tRNA aminoacylation
ASA_1069	COG2888	peptidyl-tyrosine sulfation
ASA_1070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASA_1071	COG4535	Mg2 and Co2 transporter CorC
ASA_1072	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASA_1073	COG1702	phosphate starvation-inducible protein PhoH
ASA_1074	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASA_1075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASA_1077	COG3706	GGDEF domain
ASA_1080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASA_1084	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASA_1086	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASA_1088	COG0516	GMP reductase activity
ASA_1090	COG0642	Histidine kinase
ASA_1091	COG0745	RESPONSE REGULATOR receiver
ASA_1098	COG3214	Protein conserved in bacteria
ASA_1102	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ASA_1103	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ASA_1104	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASA_1105	COG1053	succinate dehydrogenase
ASA_1107	COG0584	glycerophosphoryl diester phosphodiesterase
ASA_1108	COG1511	domain protein
ASA_1108	COG3264	Mechanosensitive ion channel
ASA_1111	COG0739	heme binding
ASA_1114	COG0583	DNA-binding transcription factor activity
ASA_1118	COG0583	DNA-binding transcription factor activity
ASA_1119	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ASA_1125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASA_1126	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASA_1128	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ASA_1129	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASA_1130	COG0546	phosphoglycolate phosphatase activity
ASA_1131	COG0180	Tryptophanyl-tRNA synthetase
ASA_1134	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASA_1136	COG1012	belongs to the aldehyde dehydrogenase family
ASA_1138	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASA_1140	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASA_1140	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASA_1140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASA_1142	COG0488	(ABC) transporter
ASA_1144	COG0366	Alpha amylase catalytic
ASA_1146	COG0443	Heat shock 70 kDa protein
ASA_1152	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASA_1154	COG0490	domain, Protein
ASA_1154	COG0471	metal ion transport
ASA_1165	COG2801	Transposase and inactivated derivatives
ASA_1167	COG0012	GTP binding
ASA_1168	COG0193	aminoacyl-tRNA hydrolase activity
ASA_1169	COG0737	Belongs to the 5'-nucleotidase family
ASA_1170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASA_1172	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASA_1173	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ASA_1174	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASA_1175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASA_1176	COG2890	protein-(glutamine-N5) methyltransferase activity
ASA_1180	COG1301	dicarboxylic acid transport
ASA_1183	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASA_1186	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASA_1187	COG1115	amino acid carrier protein
ASA_1190	COG0714	Associated with various cellular activities
ASA_1193	COG0583	DNA-binding transcription factor activity
ASA_1194	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASA_1195	COG1678	Uncharacterized ACR, COG1678
ASA_1197	COG0189	ligase activity
ASA_1200	COG3091	SprT-like family
ASA_1202	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASA_1205	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ASA_1206	COG0739	heme binding
ASA_1207	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASA_1210	COG0463	Glycosyl transferase, family 2
ASA_1213	COG2989	Protein conserved in bacteria
ASA_1214	COG3108	Peptidase M15
ASA_1216	COG2860	membrane
ASA_1218	COG1196	nuclear chromosome segregation
ASA_1219	COG3115	cell septum assembly
ASA_1220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASA_1222	COG1328	CTP reductase activity
ASA_1224	COG0602	queuosine metabolic process
ASA_1229	COG1566	PFAM secretion protein HlyD family protein
ASA_1230	COG1846	Transcriptional regulator
ASA_1233	COG0281	malic enzyme
ASA_1234	COG3290	protein histidine kinase activity
ASA_1238	COG3706	GGDEF domain
ASA_1239	COG0346	lactoylglutathione lyase activity
ASA_1240	COG0745	RESPONSE REGULATOR receiver
ASA_1241	COG5002	protein histidine kinase activity
ASA_1243	COG4783	chaperone-mediated protein folding
ASA_1245	COG1940	carbohydrate kinase activity
ASA_1246	COG3142	Participates in the control of copper homeostasis
ASA_1247	COG0545	Peptidyl-prolyl cis-trans isomerase
ASA_1248	COG1131	(ABC) transporter
ASA_1252	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASA_1256	COG0019	diaminopimelate decarboxylase activity
ASA_1257	COG1115	amino acid carrier protein
ASA_1258	COG0095	Lipoate-protein ligase
ASA_1259	COG2233	PERMEase
ASA_1260	COG3706	GGDEF domain
ASA_1260	COG0745	RESPONSE REGULATOR receiver
ASA_1262	COG0534	Mate efflux family protein
ASA_1263	COG2207	Transcriptional regulator
ASA_1264	COG0281	malic enzyme
ASA_1265	COG2885	chlorophyll binding
ASA_1265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ASA_1270	COG0733	neurotransmitter:sodium symporter activity
ASA_1271	COG1752	Esterase of the alpha-beta hydrolase superfamily
ASA_1272	COG3706	GGDEF domain
ASA_1273	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_1274	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASA_1276	COG1032	radical SAM domain protein
ASA_1282	COG0673	inositol 2-dehydrogenase activity
ASA_1283	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASA_1284	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASA_1285	COG0739	heme binding
ASA_1285	COG1196	nuclear chromosome segregation
ASA_1285	COG0741	lytic transglycosylase activity
ASA_1286	COG0366	Alpha amylase catalytic
ASA_1290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASA_1292	COG0788	formyltetrahydrofolate deformylase activity
ASA_1293	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASA_1295	COG3118	belongs to the thioredoxin family
ASA_1296	COG2091	lysine biosynthetic process via aminoadipic acid
ASA_1297	COG0791	NLP P60 protein
ASA_1298	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ASA_1301	COG1376	ErfK ybiS ycfS ynhG family protein
ASA_1301	COG1388	LysM domain
ASA_1309	COG4584	PFAM Integrase catalytic
ASA_1310	COG1484	DNA-dependent DNA replication
ASA_1311	COG3209	COG3209 Rhs family protein
ASA_1316	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ASA_1318	COG1960	acyl-CoA dehydrogenase activity
ASA_1319	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASA_1321	COG0469	pyruvate kinase activity
ASA_1322	COG1737	Transcriptional regulator
ASA_1324	COG3290	protein histidine kinase activity
ASA_1325	COG0745	RESPONSE REGULATOR receiver
ASA_1327	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASA_1331	COG1342	Belongs to the UPF0251 family
ASA_1334	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ASA_1336	COG1677	Flagellar hook-basal body complex protein FliE
ASA_1338	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASA_1348	COG1987	bacterial-type flagellum assembly
ASA_1349	COG1684	flagellar biosynthetic protein fliR
ASA_1351	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASA_1353	COG0455	bacterial-type flagellum organization
ASA_1356	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ASA_1357	COG2198	Histidine kinase
ASA_1357	COG0643	Histidine kinase
ASA_1358	COG2201	protein-glutamate methylesterase activity
ASA_1359	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASA_1360	COG1360	Flagellar Motor Protein
ASA_1361	COG1192	Involved in chromosome partitioning
ASA_1363	COG0835	chemotaxis
ASA_1366	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASA_1367	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASA_1368	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASA_1369	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ASA_1370	COG1138	Cytochrome C-type biogenesis protein
ASA_1371	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASA_1372	COG3088	subunit of a heme lyase
ASA_1372	COG4235	cytochrome complex assembly
ASA_1376	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ASA_1377	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASA_1377	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASA_1380	COG0259	pyridoxamine-phosphate oxidase activity
ASA_1381	COG0625	glutathione transferase activity
ASA_1383	COG3153	acetyltransferase
ASA_1388	COG2850	peptidyl-arginine hydroxylation
ASA_1389	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASA_1390	COG2915	High frequency lysogenization protein hflD homolog
ASA_1391	COG0482	sulfurtransferase activity
ASA_1395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASA_1397	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASA_1397	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASA_1397	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_1402	COG0159	tryptophan synthase activity
ASA_1403	COG0133	tryptophan synthase activity
ASA_1404	COG0134	indole-3-glycerol-phosphate synthase activity
ASA_1404	COG0135	phosphoribosylanthranilate isomerase activity
ASA_1405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASA_1406	COG0512	Glutamine amidotransferase of anthranilate synthase
ASA_1406	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASA_1407	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASA_1409	COG0613	PHP domain protein
ASA_1410	COG0009	L-threonylcarbamoyladenylate synthase
ASA_1412	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ASA_1414	COG1946	Acyl-CoA thioesterase
ASA_1417	COG1309	transcriptional regulator
ASA_1418	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_1419	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASA_1420	COG1538	Outer membrane efflux protein
ASA_1423	COG1091	dTDP-4-dehydrorhamnose reductase activity
ASA_1427	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASA_1428	COG1459	type II secretion system
ASA_1437	COG1450	Type ii and iii secretion system protein
ASA_1441	COG0438	transferase activity, transferring glycosyl groups
ASA_1442	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ASA_1449	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASA_1455	COG2801	Transposase and inactivated derivatives
ASA_1456	COG0438	transferase activity, transferring glycosyl groups
ASA_1460	COG3132	Protein of unknown function, DUF480
ASA_1463	COG4584	PFAM Integrase catalytic
ASA_1464	COG1484	DNA-dependent DNA replication
ASA_1471	COG1278	Cold shock
ASA_1480	COG1187	pseudouridine synthase activity
ASA_1482	COG4166	transmembrane transport
ASA_1483	COG0622	Phosphoesterase
ASA_1487	COG0784	Response regulator, receiver
ASA_1487	COG0835	chemotaxis
ASA_1488	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASA_1489	COG1815	bacterial-type flagellum-dependent cell motility
ASA_1490	COG1558	bacterial-type flagellum-dependent cell motility
ASA_1493	COG4787	bacterial-type flagellum-dependent cell motility
ASA_1494	COG4786	Flagellar basal body rod
ASA_1495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASA_1496	COG1706	bacterial-type flagellum-dependent cell motility
ASA_1500	COG2239	Acts as a magnesium transporter
ASA_1501	COG0248	Ppx GppA phosphatase
ASA_1502	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASA_1506	COG3852	Histidine kinase
ASA_1507	COG2204	response regulator
ASA_1508	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASA_1509	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ASA_1510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASA_1511	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASA_1515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASA_1518	COG0590	tRNA wobble adenosine to inosine editing
ASA_1519	COG0573	inorganic phosphate transmembrane transporter activity
ASA_1520	COG0581	inorganic phosphate transmembrane transporter activity
ASA_1522	COG0704	Plays a role in the regulation of phosphate uptake
ASA_1523	COG1253	flavin adenine dinucleotide binding
ASA_1526	COG0531	amino acid
ASA_1528	COG1126	abc transporter atp-binding protein
ASA_1529	COG0765	amino acid transport
ASA_1530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_1531	COG3706	GGDEF domain
ASA_1532	COG2271	Major facilitator Superfamily
ASA_1535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASA_1539	COG1785	Belongs to the alkaline phosphatase family
ASA_1540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ASA_1541	COG0123	including yeast histone deacetylase and acetoin utilization protein
ASA_1543	COG1199	ATP-dependent helicase activity
ASA_1544	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ASA_1546	COG1448	Aminotransferase
ASA_1547	COG0433	COG0433 Predicted ATPase
ASA_1550	COG0658	competence protein
ASA_1550	COG2333	competence protein COMEC
ASA_1551	COG1132	(ABC) transporter
ASA_1552	COG1663	tetraacyldisaccharide 4'-kinase activity
ASA_1553	COG2835	tetraacyldisaccharide 4'-kinase activity
ASA_1554	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ASA_1555	COG2197	response regulator
ASA_1556	COG0322	excinuclease ABC activity
ASA_1591	COG4695	Portal protein
ASA_1604	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASA_1606	COG4974	Belongs to the 'phage' integrase family
ASA_1612	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASA_1614	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASA_1627	COG2119	membrane
ASA_1628	COG0023	Translation Initiation Factor
ASA_1636	COG2205	protein histidine kinase activity
ASA_1636	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_1638	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ASA_1639	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASA_1640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ASA_1641	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASA_1642	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASA_1643	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASA_1647	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASA_1648	COG0505	Belongs to the CarA family
ASA_1649	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASA_1650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASA_1657	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASA_1658	COG0513	Belongs to the DEAD box helicase family
ASA_1663	COG0789	Transcriptional regulator
ASA_1666	COG0493	'glutamate synthase
ASA_1667	COG0070	glutamate synthase
ASA_1667	COG0069	glutamate synthase activity
ASA_1667	COG0067	glutamate synthase
ASA_1668	COG1242	4 iron, 4 sulfur cluster binding
ASA_1682	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASA_1683	COG1288	antiporter activity
ASA_1684	COG0436	Aminotransferase
ASA_1686	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ASA_1687	COG2027	D-alanyl-D-alanine carboxypeptidase
ASA_1688	COG1061	Type III restriction enzyme res subunit
ASA_1689	COG1566	PFAM secretion protein HlyD family protein
ASA_1691	COG1966	Carbon starvation protein
ASA_1692	COG3279	Response regulator of the LytR AlgR family
ASA_1693	COG3275	phosphorelay sensor kinase activity
ASA_1695	COG1454	alcohol dehydrogenase
ASA_1695	COG1012	belongs to the aldehyde dehydrogenase family
ASA_1697	COG2095	MarC family integral membrane protein
ASA_1699	COG0601	transmembrane transport
ASA_1700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASA_1701	COG0444	Belongs to the ABC transporter superfamily
ASA_1703	COG0861	Integral membrane protein TerC family
ASA_1704	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASA_1706	COG1301	dicarboxylic acid transport
ASA_1709	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASA_1712	COG0537	adenosine 5'-monophosphoramidase activity
ASA_1719	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASA_1720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASA_1724	COG1007	ATP synthesis coupled electron transport
ASA_1725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1727	COG0713	ATP synthesis coupled electron transport
ASA_1728	COG0839	Belongs to the complex I subunit 6 family
ASA_1729	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASA_1731	COG1034	ATP synthesis coupled electron transport
ASA_1734	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1734	COG0649	NAD binding
ASA_1735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1736	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1737	COG1360	Flagellar Motor Protein
ASA_1738	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASA_1741	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ASA_1744	COG4597	amino acid ABC transporter
ASA_1745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_1746	COG0765	amino acid transport
ASA_1747	COG1126	abc transporter atp-binding protein
ASA_1749	COG0724	RNA recognition motif
ASA_1750	COG4989	oxidoreductase activity
ASA_1755	COG3437	response regulator, receiver
ASA_1756	COG0583	DNA-binding transcription factor activity
ASA_1763	COG2814	Major facilitator Superfamily
ASA_1764	COG0583	DNA-binding transcription factor activity
ASA_1766	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASA_1767	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASA_1768	COG0539	negative regulation of cytoplasmic translation
ASA_1769	COG0776	regulation of translation
ASA_1771	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ASA_1772	COG0284	orotidine-5'-phosphate decarboxylase activity
ASA_1775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ASA_1776	COG0602	queuosine metabolic process
ASA_1777	COG3530	Putative quorum-sensing-regulated virulence factor
ASA_1778	COG2096	Adenosyltransferase
ASA_1779	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASA_1781	COG1757	Na H antiporter
ASA_1782	COG1435	thymidine kinase activity
ASA_1786	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASA_1788	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ASA_1789	COG0437	4 iron, 4 sulfur cluster binding
ASA_1790	COG5557	Pfam Polysulphide reductase, NrfD
ASA_1791	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ASA_1792	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ASA_1793	COG1773	rubredoxin
ASA_1795	COG0601	transmembrane transport
ASA_1796	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASA_1799	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ASA_1800	COG0375	protein maturation
ASA_1801	COG0309	Hydrogenase expression formation protein (HypE)
ASA_1803	COG0298	carbon dioxide binding
ASA_1804	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ASA_1806	COG1921	L-seryl-tRNASec selenium transferase activity
ASA_1808	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ASA_1810	COG3260	NADH ubiquinone oxidoreductase 20
ASA_1811	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASA_1812	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ASA_1812	COG3261	NADH dehydrogenase
ASA_1813	COG0650	Formate hydrogenlyase subunit 4
ASA_1814	COG0651	ATP synthesis coupled electron transport
ASA_1815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASA_1816	COG3158	transport of potassium into the cell
ASA_1820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASA_1825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASA_1826	COG0326	Molecular chaperone. Has ATPase activity
ASA_1827	COG0563	adenylate kinase activity
ASA_1828	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASA_1829	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ASA_1830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASA_1831	COG0840	transmembrane signaling receptor activity
ASA_1834	COG5001	Diguanylate cyclase
ASA_1834	COG3300	MHYT domain
ASA_1835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASA_1839	COG1021	2,3-dihydroxybenzoate-AMP ligase
ASA_1840	COG3433	isochorismatase activity
ASA_1840	COG1535	isochorismatase
ASA_1841	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASA_1842	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_1844	COG3321	synthase
ASA_1844	COG0300	oxidoreductase activity
ASA_1844	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_1844	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASA_1844	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_1845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASA_1846	COG2977	Belongs to the P-Pant transferase superfamily
ASA_1847	COG1120	ATPase activity
ASA_1848	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASA_1849	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASA_1850	COG4771	TonB-dependent receptor
ASA_1854	COG0598	Magnesium transport protein CorA
ASA_1858	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ASA_1859	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASA_1860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASA_1863	COG1570	exodeoxyribonuclease VII activity
ASA_1864	COG3038	cytochrome b561
ASA_1868	COG0516	GMP reductase activity
ASA_1868	COG0517	IMP dehydrogenase activity
ASA_1869	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASA_1869	COG0519	Catalyzes the synthesis of GMP from XMP
ASA_1875	COG1025	Belongs to the peptidase M16 family
ASA_1876	COG2062	phosphohistidine phosphatase, SixA
ASA_1878	COG0697	spore germination
ASA_1879	COG4166	transmembrane transport
ASA_1880	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ASA_1881	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ASA_1883	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASA_1884	COG1136	(ABC) transporter
ASA_1885	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASA_1886	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ASA_1888	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASA_1889	COG0740	serine-type endopeptidase activity
ASA_1890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASA_1891	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASA_1892	COG0776	regulation of translation
ASA_1893	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASA_1894	COG0488	(ABC) transporter
ASA_1895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASA_1896	COG3162	membrane
ASA_1899	COG1024	Enoyl-CoA hydratase
ASA_1899	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASA_1900	COG1115	amino acid carrier protein
ASA_1901	COG0456	acetyltransferase
ASA_1903	COG1584	GPR1 FUN34 yaaH family protein
ASA_1910	COG1024	Enoyl-CoA hydratase
ASA_1911	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASA_1912	COG1960	acyl-CoA dehydrogenase activity
ASA_1914	COG1960	acyl-CoA dehydrogenase activity
ASA_1915	COG1024	Enoyl-CoA hydratase
ASA_1916	COG1024	Enoyl-CoA hydratase
ASA_1918	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_1920	COG0730	response to heat
ASA_1929	COG3706	GGDEF domain
ASA_1930	COG2840	Smr protein MutS2
ASA_1931	COG2890	protein-(glutamine-N5) methyltransferase activity
ASA_1932	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASA_1934	COG0513	Belongs to the DEAD box helicase family
ASA_1935	COG5654	RES domain protein
ASA_1937	COG0814	amino acid
ASA_1938	COG1609	Transcriptional regulator
ASA_1939	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_1939	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_1940	COG1105	Belongs to the carbohydrate kinase PfkB family
ASA_1941	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASA_1941	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASA_1941	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ASA_1942	COG3313	Fe-S protein
ASA_1943	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ASA_1944	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASA_1945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASA_1946	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASA_1948	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASA_1953	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASA_1954	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASA_1955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASA_1956	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASA_1957	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASA_1958	COG0072	phenylalanine-tRNA ligase activity
ASA_1958	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASA_1959	COG0776	regulation of translation
ASA_1963	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASA_1965	COG2199	diguanylate cyclase activity
ASA_1966	COG1609	Transcriptional regulator
ASA_1967	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASA_1968	COG1879	ABC-type sugar transport system periplasmic component
ASA_1969	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASA_1971	COG1869	D-ribose catabolic process
ASA_1972	COG0625	glutathione transferase activity
ASA_1975	COG0037	tRNA processing
ASA_1976	COG0589	response to stress
ASA_1977	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASA_1980	COG2217	Heavy metal translocating P-type atpase
ASA_1982	COG2010	Cytochrome c
ASA_1985	COG3278	Belongs to the heme-copper respiratory oxidase family
ASA_1987	COG1956	GAF domain-containing protein
ASA_1988	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ASA_1990	COG0308	aminopeptidase N
ASA_1992	COG2902	Dehydrogenase
ASA_1993	COG0167	dihydroorotate dehydrogenase activity
ASA_1995	COG0116	Belongs to the methyltransferase superfamily
ASA_1995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASA_2000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASA_2001	COG1067	ATP-dependent peptidase activity
ASA_2016	COG1484	DNA-dependent DNA replication
ASA_2017	COG4584	PFAM Integrase catalytic
ASA_2031	COG4221	oxidoreductase activity
ASA_2040	COG0372	Belongs to the citrate synthase family
ASA_2041	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASA_2044	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ASA_2044	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASA_2047	COG0084	hydrolase, TatD family'
ASA_2048	COG0470	DNA polymerase III
ASA_2049	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASA_2050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASA_2051	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASA_2052	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASA_2053	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASA_2054	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_2056	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASA_2057	COG0416	fatty acid biosynthetic process
ASA_2058	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASA_2059	COG1399	metal-binding, possibly nucleic acid-binding protein
ASA_2060	COG0424	maF-like protein
ASA_2061	COG0546	phosphoglycolate phosphatase activity
ASA_2064	COG1530	ribonuclease E activity
ASA_2066	COG0306	phosphate transporter
ASA_2067	COG0717	Belongs to the dCTP deaminase family
ASA_2068	COG0572	uridine kinase
ASA_2069	COG0489	protein tyrosine kinase activity
ASA_2070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASA_2070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASA_2072	COG1254	Belongs to the acylphosphatase family
ASA_2074	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASA_2077	COG0709	Synthesizes selenophosphate from selenide and ATP
ASA_2078	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ASA_2079	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASA_2080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASA_2082	COG1643	Atp-dependent helicase
ASA_2084	COG2197	response regulator
ASA_2087	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASA_2088	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ASA_2089	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASA_2090	COG2832	Protein of unknown function (DUF454)
ASA_2091	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASA_2095	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_2096	COG2267	carboxylic ester hydrolase activity
ASA_2098	COG1214	PFAM Peptidase M22, glycoprotease
ASA_2099	COG1199	ATP-dependent helicase activity
ASA_2101	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASA_2102	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASA_2103	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASA_2104	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASA_2104	COG0131	Imidazoleglycerol-phosphate dehydratase
ASA_2105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASA_2106	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASA_2107	COG3437	response regulator, receiver
ASA_2109	COG0784	Response regulator, receiver
ASA_2109	COG2198	Histidine kinase
ASA_2109	COG2205	protein histidine kinase activity
ASA_2110	COG0107	imidazoleglycerol-phosphate synthase activity
ASA_2111	COG0140	phosphoribosyl-ATP diphosphatase activity
ASA_2111	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASA_2113	COG2378	regulation of single-species biofilm formation
ASA_2115	COG2801	Transposase and inactivated derivatives
ASA_2120	COG2003	Belongs to the UPF0758 family
ASA_2124	COG2801	Transposase and inactivated derivatives
ASA_2129	COG2801	Transposase and inactivated derivatives
ASA_2135	COG2823	Periplasmic or secreted lipoprotein
ASA_2136	COG3706	GGDEF domain
ASA_2136	COG4251	negative regulation of phosphorylation
ASA_2136	COG5001	Diguanylate cyclase
ASA_2136	COG2203	Gaf domain
ASA_2137	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASA_2138	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASA_2139	COG1129	ABC transporter
ASA_2140	COG1879	ABC-type sugar transport system periplasmic component
ASA_2144	COG2824	Alkylphosphonate utilization operon protein PhnA
ASA_2145	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASA_2145	COG1024	Enoyl-CoA hydratase
ASA_2146	COG0183	Belongs to the thiolase family
ASA_2147	COG0714	Associated with various cellular activities
ASA_2156	COG2067	long-chain fatty acid transport protein
ASA_2157	COG2067	long-chain fatty acid transport protein
ASA_2158	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASA_2162	COG3123	guanosine phosphorylase activity
ASA_2163	COG1760	l-serine dehydratase
ASA_2164	COG1760	l-serine dehydratase
ASA_2165	COG2951	lytic endotransglycosylase activity
ASA_2166	COG3100	YcgL domain-containing protein
ASA_2167	COG0850	regulation of cytokinetic process
ASA_2168	COG2894	cell division
ASA_2169	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ASA_2171	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASA_2179	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ASA_2180	COG0697	spore germination
ASA_2181	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ASA_2182	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASA_2183	COG0307	riboflavin synthase, alpha
ASA_2185	COG0534	Mate efflux family protein
ASA_2190	COG0417	DNA replication proofreading
ASA_2192	COG2199	diguanylate cyclase activity
ASA_2192	COG2203	Gaf domain
ASA_2195	COG1560	Kdo2-lipid A biosynthetic process
ASA_2196	COG1560	Kdo2-lipid A biosynthetic process
ASA_2198	COG0583	DNA-binding transcription factor activity
ASA_2199	COG0673	inositol 2-dehydrogenase activity
ASA_2200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASA_2201	COG0583	DNA-binding transcription factor activity
ASA_2202	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_2205	COG3134	Outer membrane lipoprotein
ASA_2209	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASA_2213	COG4681	YaeQ
ASA_2223	COG2801	Transposase and inactivated derivatives
ASA_2226	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASA_2227	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ASA_2230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASA_2231	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASA_2233	COG0205	6-phosphofructokinase activity
ASA_2242	COG1011	Hydrolase
ASA_2243	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASA_2254	COG3593	DNA synthesis involved in DNA repair
ASA_2255	COG4977	sequence-specific DNA binding
ASA_2257	COG0583	DNA-binding transcription factor activity
ASA_2258	COG0730	response to heat
ASA_2261	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASA_2263	COG0386	Belongs to the glutathione peroxidase family
ASA_2264	COG0513	Belongs to the DEAD box helicase family
ASA_2267	COG1742	UPF0060 membrane protein
ASA_2275	COG2329	Antibiotic biosynthesis monooxygenase
ASA_2276	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ASA_2280	COG3243	poly(R)-hydroxyalkanoic acid synthase
ASA_2282	COG2501	S4 domain
ASA_2284	COG1132	(ABC) transporter
ASA_2287	COG3118	belongs to the thioredoxin family
ASA_2288	COG0471	metal ion transport
ASA_2289	COG0058	SHG alpha-glucan phosphorylase activity
ASA_2293	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASA_2295	COG0814	amino acid
ASA_2296	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ASA_2297	COG0514	ATP-dependent DNA helicase (RecQ)
ASA_2298	COG2766	serine protein kinase
ASA_2300	COG2719	SpoVR family
ASA_2301	COG2186	Transcriptional regulator
ASA_2302	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASA_2303	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ASA_2304	COG0586	Pfam SNARE associated Golgi protein
ASA_2306	COG0556	nucleotide-excision repair
ASA_2308	COG0569	domain protein
ASA_2308	COG2985	domain, Protein
ASA_2309	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ASA_2313	COG4565	transcriptional regulatory protein
ASA_2314	COG3290	protein histidine kinase activity
ASA_2315	COG1846	Transcriptional regulator
ASA_2315	COG1940	carbohydrate kinase activity
ASA_2316	COG0840	transmembrane signaling receptor activity
ASA_2317	COG3012	SEC-C Motif Domain Protein
ASA_2318	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASA_2319	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
ASA_2320	COG0247	lactate metabolic process
ASA_2322	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ASA_2323	COG0437	4 iron, 4 sulfur cluster binding
ASA_2324	COG3301	Polysulphide reductase, NrfD
ASA_2327	COG3088	subunit of a heme lyase
ASA_2327	COG4235	cytochrome complex assembly
ASA_2330	COG3033	Beta-eliminating lyase
ASA_2332	COG3046	protein related to deoxyribodipyrimidine photolyase
ASA_2333	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASA_2338	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASA_2339	COG0583	DNA-binding transcription factor activity
ASA_2341	COG4774	siderophore transport
ASA_2342	COG2207	Transcriptional regulator
ASA_2342	COG3708	Transcriptional regulator
ASA_2344	COG0583	DNA-binding transcription factor activity
ASA_2345	COG2910	NAD(P)H-binding
ASA_2348	COG0612	Peptidase, M16
ASA_2349	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASA_2350	COG1944	ATP diphosphatase activity
ASA_2351	COG2116	formate transmembrane transporter activity
ASA_2352	COG1882	Formate acetyltransferase
ASA_2354	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASA_2355	COG0045	succinate-CoA ligase (ADP-forming) activity
ASA_2356	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASA_2357	COG0567	Dehydrogenase, E1 component
ASA_2359	COG1053	succinate dehydrogenase
ASA_2360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ASA_2361	COG2009	succinate dehydrogenase
ASA_2365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASA_2366	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ASA_2366	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASA_2368	COG3069	C4-dicarboxylate transmembrane transporter activity
ASA_2371	COG1451	nucleotide metabolic process
ASA_2374	COG0254	rRNA binding
ASA_2375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASA_2376	COG0469	pyruvate kinase activity
ASA_2378	COG1874	Beta-galactosidase
ASA_2379	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ASA_2380	COG3833	ABC-type maltose transport systems, permease component
ASA_2381	COG1175	transmembrane transport
ASA_2382	COG2182	Extracellular solute-binding protein
ASA_2388	COG4580	involved in the transport of maltose and maltodextrins
ASA_2389	COG1609	Transcriptional regulator
ASA_2390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASA_2391	COG1085	galactose-1-phosphate uridylyltransferase
ASA_2392	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASA_2394	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASA_2395	COG1129	ABC transporter
ASA_2396	COG1879	ABC-type sugar transport system periplasmic component
ASA_2397	COG1069	ribulokinase activity
ASA_2399	COG2160	L-arabinose isomerase activity
ASA_2400	COG0583	DNA-binding transcription factor activity
ASA_2402	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASA_2405	COG2925	Exonuclease
ASA_2408	COG1380	Effector of murein hydrolase LrgA
ASA_2409	COG1346	cytolysis
ASA_2410	COG0295	cytidine deaminase activity
ASA_2411	COG1022	Amp-dependent synthetase and ligase
ASA_2414	COG0861	Integral membrane protein TerC family
ASA_2416	COG2199	diguanylate cyclase activity
ASA_2419	COG2154	pterin-4-alpha-carbinolamine dehydratase
ASA_2421	COG3768	UPF0283 membrane protein
ASA_2422	COG3106	COG3106 Predicted ATPase
ASA_2425	COG1842	Phage shock protein A
ASA_2426	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ASA_2428	COG4168	peptide transport system, permease
ASA_2429	COG4171	peptide transport system, permease
ASA_2430	COG4172	Belongs to the ABC transporter superfamily
ASA_2431	COG4172	Belongs to the ABC transporter superfamily
ASA_2433	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ASA_2434	COG1286	toxin biosynthetic process
ASA_2435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASA_2436	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASA_2437	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ASA_2438	COG1674	ftsk spoiiie
ASA_2438	COG0531	amino acid
ASA_2440	COG0492	ferredoxin-NADP+ reductase activity
ASA_2441	COG3706	GGDEF domain
ASA_2442	COG3134	Outer membrane lipoprotein
ASA_2443	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ASA_2444	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ASA_2445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASA_2446	COG0542	response to heat
ASA_2447	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASA_2448	COG1278	Cold shock
ASA_2449	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASA_2455	COG3501	Rhs element vgr protein
ASA_2474	COG0659	secondary active sulfate transmembrane transporter activity
ASA_2484	COG0697	spore germination
ASA_2485	COG4657	Part of a membrane complex involved in electron transport
ASA_2486	COG2878	Part of a membrane complex involved in electron transport
ASA_2488	COG4658	electron transport chain
ASA_2489	COG4659	FMN binding
ASA_2491	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASA_2492	COG0346	lactoylglutathione lyase activity
ASA_2495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASA_2496	COG2056	Na+-H+ antiporter family
ASA_2497	COG5001	Diguanylate cyclase
ASA_2497	COG3300	MHYT domain
ASA_2499	COG0513	Belongs to the DEAD box helicase family
ASA_2500	COG2050	protein possibly involved in aromatic compounds catabolism
ASA_2502	COG0247	lactate metabolic process
ASA_2502	COG0277	FAD linked oxidase domain protein
ASA_2504	COG1253	flavin adenine dinucleotide binding
ASA_2505	COG1902	pentaerythritol trinitrate reductase activity
ASA_2506	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASA_2507	COG0647	UMP catabolic process
ASA_2508	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ASA_2508	COG4651	solute:proton antiporter activity
ASA_2510	COG0367	asparagine synthase
ASA_2515	COG0625	glutathione transferase activity
ASA_2516	COG0625	glutathione transferase activity
ASA_2521	COG0564	pseudouridine synthase activity
ASA_2523	COG0840	transmembrane signaling receptor activity
ASA_2525	COG0670	Belongs to the BI1 family
ASA_2526	COG1289	transmembrane transporter activity
ASA_2527	COG2920	part of a sulfur-relay system
ASA_2528	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ASA_2529	COG0285	dihydrofolate synthase activity
ASA_2530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ASA_2531	COG0101	tRNA pseudouridine synthase activity
ASA_2533	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASA_2534	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASA_2535	COG0671	phosphoesterase, PA-phosphatase related
ASA_2536	COG1464	Belongs to the NlpA lipoprotein family
ASA_2544	COG0574	Belongs to the PEP-utilizing enzyme family
ASA_2544	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASA_2545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ASA_2553	COG0672	)-iron permease
ASA_2566	COG1285	pathogenesis
ASA_2576	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASA_2577	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASA_2577	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ASA_2578	COG0527	aspartate kinase activity
ASA_2580	COG1368	sulfuric ester hydrolase activity
ASA_2581	COG1619	proteins homologs of microcin C7 resistance protein MccF
ASA_2583	COG0393	Putative heavy-metal-binding
ASA_2584	COG1252	NADH dehydrogenase
ASA_2589	COG2354	Protein conserved in bacteria
ASA_2591	COG0047	phosphoribosylformylglycinamidine synthase activity
ASA_2591	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASA_2592	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ASA_2594	COG1645	bacterial-type flagellum-dependent swarming motility
ASA_2595	COG1160	GTP binding
ASA_2596	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASA_2597	COG2976	Protein conserved in bacteria
ASA_2598	COG0124	histidyl-tRNA synthetase
ASA_2599	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASA_2600	COG1426	Protein conserved in bacteria
ASA_2602	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASA_2603	COG0105	UTP biosynthetic process
ASA_2604	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASA_2606	COG0633	Ferredoxin
ASA_2607	COG0443	Heat shock 70 kDa protein
ASA_2608	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASA_2611	COG0822	iron-sulfur transferase activity
ASA_2612	COG1104	cysteine desulfurase activity
ASA_2620	COG2897	thiosulfate sulfurtransferase activity
ASA_2621	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASA_2622	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASA_2623	COG1862	Preprotein translocase
ASA_2624	COG0343	queuine tRNA-ribosyltransferase activity
ASA_2625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ASA_2626	COG0517	IMP dehydrogenase activity
ASA_2627	COG0450	alkyl hydroperoxide reductase
ASA_2628	COG3634	alkyl hydroperoxide reductase activity
ASA_2631	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASA_2631	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASA_2632	COG0509	glycine decarboxylation via glycine cleavage system
ASA_2633	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASA_2634	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASA_2635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASA_2640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASA_2641	COG0583	DNA-binding transcription factor activity
ASA_2642	COG2814	Major facilitator Superfamily
ASA_2643	COG0444	Belongs to the ABC transporter superfamily
ASA_2644	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASA_2645	COG0601	transmembrane transport
ASA_2647	COG0625	glutathione transferase activity
ASA_2649	COG0483	inositol monophosphate 1-phosphatase activity
ASA_2653	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASA_2655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASA_2661	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASA_2662	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASA_2665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASA_2665	COG0301	tRNA thio-modification
ASA_2667	COG4953	penicillin-binding protein 1C
ASA_2668	COG2373	Large extracellular alpha-helical protein
ASA_2671	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASA_2675	COG4215	(ABC) transporter
ASA_2678	COG2431	L-lysine efflux transmembrane transporter activity
ASA_2679	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ASA_2681	COG1393	Belongs to the ArsC family
ASA_2683	COG4783	chaperone-mediated protein folding
ASA_2684	COG0425	Belongs to the sulfur carrier protein TusA family
ASA_2685	COG0628	permease
ASA_2688	COG3842	ATPase activity
ASA_2690	COG1175	transmembrane transport
ASA_2691	COG2182	Extracellular solute-binding protein
ASA_2692	COG3081	Nucleoid-associated protein
ASA_2693	COG3082	Protein of unknown function (DUF1414)
ASA_2694	COG3083	sulfuric ester hydrolase activity
ASA_2695	COG4771	TonB-dependent receptor
ASA_2696	COG1770	oligopeptidase
ASA_2700	COG4574	serine-type endopeptidase inhibitor activity
ASA_2701	COG3085	chromosome segregation
ASA_2703	COG1605	Chorismate mutase
ASA_2703	COG0287	Prephenate dehydrogenase
ASA_2704	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASA_2705	COG0584	glycerophosphoryl diester phosphodiesterase
ASA_2706	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASA_2707	COG1349	DNA-binding transcription factor activity
ASA_2708	COG2271	Major facilitator Superfamily
ASA_2709	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASA_2710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASA_2711	COG0583	DNA-binding transcription factor activity
ASA_2716	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ASA_2717	COG0656	L-ascorbic acid biosynthetic process
ASA_2718	COG2814	Major facilitator Superfamily
ASA_2720	COG1294	oxidase, subunit
ASA_2722	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASA_2723	COG2979	Protein of unknown function (DUF533)
ASA_2727	COG0583	DNA-binding transcription factor activity
ASA_2729	COG2807	transmembrane transport
ASA_2730	COG1187	pseudouridine synthase activity
ASA_2731	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASA_2733	COG0346	lactoylglutathione lyase activity
ASA_2740	COG1166	arginine decarboxylase activity
ASA_2741	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASA_2746	COG2353	YceI-like domain
ASA_2747	COG0583	DNA-binding transcription factor activity
ASA_2749	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ASA_2750	COG0840	transmembrane signaling receptor activity
ASA_2752	COG0302	gtp cyclohydrolase
ASA_2754	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASA_2759	COG0596	Alpha beta hydrolase
ASA_2760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ASA_2763	COG0314	molybdopterin synthase activity
ASA_2764	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ASA_2765	COG0315	cyclic pyranopterin monophosphate synthase activity
ASA_2766	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASA_2767	COG3005	denitrification pathway
ASA_2769	COG0348	domain, Protein
ASA_2770	COG0437	4 iron, 4 sulfur cluster binding
ASA_2771	COG0243	molybdopterin cofactor binding
ASA_2773	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASA_2774	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASA_2775	COG3850	Histidine kinase
ASA_2776	COG2197	response regulator
ASA_2778	COG0784	Response regulator, receiver
ASA_2778	COG2205	protein histidine kinase activity
ASA_2782	COG0121	glutamine amidotransferase
ASA_2783	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASA_2784	COG1960	acyl-CoA dehydrogenase activity
ASA_2785	COG0784	Response regulator, receiver
ASA_2785	COG3437	response regulator, receiver
ASA_2787	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASA_2788	COG0328	RNA-DNA hybrid ribonuclease activity
ASA_2789	COG2226	methyltransferase
ASA_2790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASA_2791	COG0741	lytic transglycosylase activity
ASA_2791	COG1388	LysM domain
ASA_2792	COG3021	interspecies interaction between organisms
ASA_2794	COG1607	acyl-coa hydrolase
ASA_2799	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASA_2802	COG2911	Protein conserved in bacteria
ASA_2803	COG0729	surface antigen
ASA_2805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASA_2806	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASA_2808	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASA_2810	COG4134	Bacterial extracellular solute-binding protein
ASA_2811	COG4135	transport system, permease component
ASA_2812	COG4136	ATPase activity
ASA_2813	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASA_2814	COG2951	lytic endotransglycosylase activity
ASA_2815	COG1846	Transcriptional regulator
ASA_2817	COG0033	Phosphoglucomutase
ASA_2818	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ASA_2819	COG0596	Alpha beta hydrolase
ASA_2822	COG0716	FMN binding
ASA_2824	COG0735	belongs to the Fur family
ASA_2825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASA_2827	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASA_2827	COG1263	PTS System
ASA_2827	COG2190	(PTS) system
ASA_2828	COG0363	glucosamine-6-phosphate deaminase activity
ASA_2829	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASA_2830	COG1940	carbohydrate kinase activity
ASA_2830	COG1846	Transcriptional regulator
ASA_2832	COG2801	Transposase and inactivated derivatives
ASA_2835	COG0438	transferase activity, transferring glycosyl groups
ASA_2839	COG1484	DNA-dependent DNA replication
ASA_2840	COG4584	PFAM Integrase catalytic
ASA_2843	COG0217	transcriptional regulatory protein
ASA_2844	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASA_2845	COG1801	Protein of unknown function DUF72
ASA_2846	COG4106	trans-aconitate 2-methyltransferase activity
ASA_2847	COG0500	methyltransferase
ASA_2851	COG0450	alkyl hydroperoxide reductase
ASA_2853	COG0583	DNA-binding transcription factor activity
ASA_2855	COG0791	NLP P60 protein
ASA_2858	COG1309	transcriptional regulator
ASA_2866	COG0534	Mate efflux family protein
ASA_2868	COG2841	Protein conserved in bacteria
ASA_2871	COG3217	Mosc domain protein beta barrel domain protein
ASA_2871	COG3217	Mosc domain protein beta barrel domain protein
ASA_2871	COG0633	Ferredoxin
ASA_2871	COG0633	Ferredoxin
ASA_2873	COG0501	Belongs to the peptidase M48B family
ASA_2874	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASA_2875	COG1073	alpha beta
ASA_2875	COG2226	methyltransferase
ASA_2876	COG0156	8-amino-7-oxononanoate synthase activity
ASA_2877	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASA_2881	COG0017	Asparaginyl-tRNA synthetase
ASA_2882	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ASA_2885	COG0583	DNA-binding transcription factor activity
ASA_2886	COG1393	Belongs to the ArsC family
ASA_2887	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASA_2888	COG1876	peptidase activity
ASA_2890	COG3263	regulation of cellular component size
ASA_2894	COG1280	lysine exporter protein (LysE YggA)
ASA_2895	COG0840	transmembrane signaling receptor activity
ASA_2899	COG1957	nucleoside hydrolase
ASA_2902	COG1454	alcohol dehydrogenase
ASA_2910	COG2894	cell division
ASA_2912	COG4964	Belongs to the GSP D family
ASA_2918	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASA_2919	COG0702	epimerase
ASA_2921	COG2867	negative regulation of translational initiation
ASA_2922	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASA_2926	COG2801	Transposase and inactivated derivatives
ASA_2938	COG0583	DNA-binding transcription factor activity
ASA_2939	COG2610	gluconate transmembrane transporter activity
ASA_2940	COG3048	D-serine ammonia-lyase activity
ASA_2942	COG0538	isocitrate dehydrogenase activity
ASA_2943	COG2207	Transcriptional regulator
ASA_2950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ASA_2951	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASA_2951	COG1263	PTS System
ASA_2952	COG1609	Transcriptional regulator
ASA_2956	COG2814	Major facilitator Superfamily
ASA_2957	COG0109	protoheme IX farnesyltransferase activity
ASA_2958	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ASA_2959	COG1845	cytochrome c oxidase, subunit III
ASA_2960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASA_2961	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ASA_2972	COG0708	Exodeoxyribonuclease III
ASA_2977	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_2978	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASA_2980	COG0095	Lipoate-protein ligase
ASA_2986	COG0640	Transcriptional regulator
ASA_2989	COG1285	pathogenesis
ASA_2995	COG0484	heat shock protein binding
ASA_2996	COG0443	Heat shock 70 kDa protein
ASA_2997	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASA_2998	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASA_2999	COG0497	DNA recombination
ASA_3001	COG1227	inorganic diphosphatase activity
ASA_3003	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_3004	COG1136	(ABC) transporter
ASA_3004	COG0577	efflux transmembrane transporter activity
ASA_3005	COG1538	Outer membrane efflux protein
ASA_3006	COG2375	cellular response to nickel ion
ASA_3007	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASA_3009	COG3328	transposase activity
ASA_3010	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASA_3015	COG1917	Cupin 2, conserved barrel domain protein
ASA_3015	COG2169	Transcriptional regulator
ASA_3018	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASA_3019	COG1917	Cupin 2, conserved barrel domain protein
ASA_3019	COG1396	sequence-specific DNA binding
ASA_3022	COG0531	amino acid
ASA_3023	COG0531	amino acid
ASA_3024	COG1283	sodium-dependent phosphate transmembrane transporter activity
ASA_3026	COG3384	dioxygenase
ASA_3029	COG0813	purine-nucleoside phosphorylase activity
ASA_3032	COG1943	Transposase
ASA_3038	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASA_3039	COG0083	homoserine kinase activity
ASA_3041	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ASA_3042	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ASA_3045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASA_3047	COG0745	RESPONSE REGULATOR receiver
ASA_3050	COG4988	ABC transporter
ASA_3051	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ASA_3055	COG1720	tRNA m6t6A37 methyltransferase activity
ASA_3059	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASA_3060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_3062	COG2190	(PTS) system
ASA_3063	COG3706	GGDEF domain
ASA_3065	COG3038	cytochrome b561
ASA_3067	COG0419	ATPase involved in DNA repair
ASA_3068	COG0420	3'-5' exonuclease activity
ASA_3070	COG2974	May be involved in recombination
ASA_3071	COG0405	Gamma-glutamyltransferase
ASA_3074	COG0469	pyruvate kinase activity
ASA_3075	COG3264	Mechanosensitive ion channel
ASA_3075	COG1196	nuclear chromosome segregation
ASA_3081	COG2801	Transposase and inactivated derivatives
ASA_3082	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASA_3084	COG3852	Histidine kinase
ASA_3087	COG4662	Binding-protein-dependent transport system inner membrane component
ASA_3089	COG0746	molybdenum cofactor guanylyltransferase activity
ASA_3090	COG0303	'Molybdopterin
ASA_3091	COG1289	transmembrane transporter activity
ASA_3092	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ASA_3099	COG2205	protein histidine kinase activity
ASA_3099	COG0784	Response regulator, receiver
ASA_3102	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASA_3103	COG0444	Belongs to the ABC transporter superfamily
ASA_3104	COG4608	Belongs to the ABC transporter superfamily
ASA_3106	COG2971	BadF BadG BcrA BcrD
ASA_3108	COG0840	transmembrane signaling receptor activity
ASA_3111	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASA_3112	COG3724	N-succinylarginine dihydrolase activity
ASA_3113	COG0616	signal peptide processing
ASA_3114	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_3115	COG0583	DNA-binding transcription factor activity
ASA_3117	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ASA_3119	COG0583	DNA-binding transcription factor activity
ASA_3121	COG1881	PFAM PEBP family protein
ASA_3123	COG0366	Alpha amylase catalytic
ASA_3130	COG3706	GGDEF domain
ASA_3131	COG0037	tRNA processing
ASA_3132	COG3590	peptidase
ASA_3134	COG0488	(ABC) transporter
ASA_3136	COG0531	amino acid
ASA_3137	COG0814	amino acid
ASA_3140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ASA_3141	COG1982	Orn Lys Arg decarboxylase major
ASA_3142	COG0531	amino acid
ASA_3143	COG3710	Transcriptional regulator
ASA_3144	COG0825	malonyl-CoA metabolic process
ASA_3146	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASA_3147	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASA_3148	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASA_3149	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASA_3150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASA_3153	COG0750	zinc metalloprotease
ASA_3154	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASA_3155	COG0575	Belongs to the CDS family
ASA_3156	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASA_3157	COG0233	cytoplasmic translational termination
ASA_3158	COG0528	UMP kinase activity
ASA_3159	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASA_3160	COG0052	Belongs to the universal ribosomal protein uS2 family
ASA_3162	COG0024	Methionine aminopeptidase
ASA_3163	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASA_3164	COG2171	N-acyltransferase activity
ASA_3166	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASA_3166	COG1263	PTS System
ASA_3168	COG4580	involved in the transport of maltose and maltodextrins
ASA_3170	COG0564	pseudouridine synthase activity
ASA_3171	COG3098	single-species biofilm formation
ASA_3176	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ASA_3178	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASA_3178	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASA_3180	COG3706	GGDEF domain
ASA_3181	COG1611	Belongs to the LOG family
ASA_3182	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASA_3183	COG0473	3-isopropylmalate dehydrogenase activity
ASA_3185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ASA_3186	COG2363	Small membrane protein
ASA_3188	COG0583	DNA-binding transcription factor activity
ASA_3189	COG0840	transmembrane signaling receptor activity
ASA_3190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASA_3193	COG1477	protein flavinylation
ASA_3194	COG2871	sodium ion transport
ASA_3195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASA_3196	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASA_3197	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASA_3198	COG1805	sodium ion transport
ASA_3199	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASA_3200	COG0271	Belongs to the BolA IbaG family
ASA_3201	COG2813	Specifically methylates the guanine in position
ASA_3203	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASA_3205	COG2211	Major facilitator Superfamily
ASA_3206	COG3248	Nucleoside-binding outer membrane protein
ASA_3207	COG1666	GTP binding
ASA_3208	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASA_3213	COG3459	Glycosyltransferase 36 associated
ASA_3216	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASA_3216	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASA_3217	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASA_3219	COG1151	hydroxylamine reductase activity
ASA_3220	COG0783	Belongs to the Dps family
ASA_3225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASA_3228	COG0300	oxidoreductase activity
ASA_3230	COG0415	Belongs to the DNA photolyase family
ASA_3231	COG0789	Transcriptional regulator
ASA_3232	COG3272	Protein of unknown function (DUF1722)
ASA_3238	COG1605	Chorismate mutase
ASA_3238	COG0077	Prephenate dehydratase
ASA_3243	COG2133	pyrroloquinoline quinone binding
ASA_3247	COG0300	oxidoreductase activity
ASA_3252	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ASA_3255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASA_3257	COG3813	Protein conserved in bacteria
ASA_3260	COG1280	lysine exporter protein (LysE YggA)
ASA_3262	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASA_3263	COG0840	transmembrane signaling receptor activity
ASA_3266	COG2198	Histidine kinase
ASA_3266	COG0643	Histidine kinase
ASA_3268	COG0835	chemotaxis
ASA_3269	COG0840	transmembrane signaling receptor activity
ASA_3271	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ASA_3272	COG2201	protein-glutamate methylesterase activity
ASA_3273	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASA_3283	COG2200	EAL domain
ASA_3283	COG2203	Gaf domain
ASA_3283	COG2199	diguanylate cyclase activity
ASA_3285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASA_3286	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASA_3287	COG0305	Participates in initiation and elongation during chromosome replication
ASA_3291	COG0737	Belongs to the 5'-nucleotidase family
ASA_3295	COG2204	response regulator
ASA_3296	COG0545	Peptidyl-prolyl cis-trans isomerase
ASA_3298	COG2900	Belongs to the SlyX family
ASA_3299	COG1047	Peptidyl-prolyl cis-trans
ASA_3300	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ASA_3302	COG0784	Response regulator, receiver
ASA_3302	COG0835	chemotaxis
ASA_3303	COG0429	hydrolase of the alpha beta-hydrolase fold
ASA_3304	COG5001	Diguanylate cyclase
ASA_3304	COG4251	negative regulation of phosphorylation
ASA_3304	COG3706	GGDEF domain
ASA_3304	COG2203	Gaf domain
ASA_3305	COG3089	Belongs to the UPF0270 family
ASA_3307	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASA_3308	COG0463	Glycosyl transferase, family 2
ASA_3310	COG0726	polysaccharide deacetylase
ASA_3311	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASA_3312	COG2076	Multidrug Resistance protein
ASA_3313	COG2076	Multidrug Resistance protein
ASA_3314	COG3954	Phosphoribulokinase
ASA_3317	COG1765	OsmC-like protein
ASA_3318	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASA_3320	COG3397	chitin binding
ASA_3325	COG3655	Transcriptional regulator
ASA_3327	COG2814	Major facilitator Superfamily
ASA_3328	COG4771	TonB-dependent receptor
ASA_3332	COG0748	coenzyme F420 binding
ASA_3333	COG3721	Heme iron utilization protein
ASA_3335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASA_3341	COG0488	(ABC) transporter
ASA_3344	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASA_3345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASA_3346	COG3178	'Phosphotransferase
ASA_3347	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ASA_3349	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ASA_3350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASA_3352	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASA_3355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASA_3357	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ASA_3359	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_3361	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASA_3362	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASA_3363	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASA_3364	COG0142	geranyltranstransferase activity
ASA_3365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ASA_3366	COG0330	HflC and HflK could
ASA_3367	COG0330	HflC and HflK could
ASA_3368	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASA_3369	COG1923	regulation of RNA biosynthetic process
ASA_3370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASA_3371	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASA_3373	COG0802	atpase or kinase
ASA_3379	COG2011	ABC-type metal ion transport system permease component
ASA_3380	COG1464	Belongs to the NlpA lipoprotein family
ASA_3382	COG0840	transmembrane signaling receptor activity
ASA_3387	COG2198	Histidine kinase
ASA_3387	COG0784	Response regulator, receiver
ASA_3387	COG5002	protein histidine kinase activity
ASA_3394	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASA_3395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ASA_3397	COG2716	regulation of RNA biosynthetic process
ASA_3398	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASA_3399	COG3013	Belongs to the UPF0304 family
ASA_3400	COG3092	negative regulation of chromosome organization
ASA_3401	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASA_3402	COG0857	belongs to the CobB CobQ family
ASA_3402	COG0280	phosphate acetyltransferase
ASA_3403	COG0440	acetolactate synthase activity
ASA_3404	COG0028	Belongs to the TPP enzyme family
ASA_3407	COG0671	phosphoesterase, PA-phosphatase related
ASA_3409	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASA_3410	COG0473	3-isopropylmalate dehydrogenase activity
ASA_3411	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASA_3412	COG0066	3-isopropylmalate dehydratase activity
ASA_3415	COG4143	(ABC) transporter
ASA_3416	COG1178	ABC-type Fe3 transport system permease component
ASA_3417	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ASA_3418	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASA_3420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASA_3426	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASA_3427	COG0564	pseudouridine synthase activity
ASA_3429	COG3300	MHYT domain
ASA_3429	COG5001	Diguanylate cyclase
ASA_3431	COG0459	protein refolding
ASA_3432	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASA_3434	COG3030	protein affecting phage T7 exclusion by the F plasmid
ASA_3435	COG1027	Aspartate ammonia-lyase
ASA_3436	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ASA_3438	COG0477	Major facilitator Superfamily
ASA_3441	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASA_3442	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASA_3446	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASA_3447	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASA_3448	COG3036	rescue of stalled ribosome
ASA_3451	COG0138	bifunctional purine biosynthesis protein purh
ASA_3452	COG0151	Belongs to the GarS family
ASA_3461	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASA_3462	COG0358	DNA primase activity
ASA_3463	COG1610	YqeY-like protein
ASA_3464	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ASA_3465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASA_3467	COG4942	peptidase
ASA_3467	COG1388	LysM domain
ASA_3468	COG1238	metal cluster binding
ASA_3469	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASA_3470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASA_3471	COG0585	pseudouridine synthase activity
ASA_3473	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASA_3474	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ASA_3475	COG0148	phosphopyruvate hydratase activity
ASA_3476	COG0504	CTP synthase activity
ASA_3477	COG3956	TIGRFAM MazG family protein
ASA_3478	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASA_3479	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASA_3481	COG4807	Protein conserved in bacteria
ASA_3482	COG3023	N-Acetylmuramoyl-L-alanine amidase
ASA_3483	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ASA_3484	COG1381	Involved in DNA repair and RecF pathway recombination
ASA_3486	COG0571	ribonuclease III activity
ASA_3487	COG0681	Belongs to the peptidase S26 family
ASA_3488	COG0481	GTPase activity
ASA_3491	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ASA_3492	COG1595	DNA-templated transcription, initiation
ASA_3493	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASA_3503	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASA_3504	COG0191	fructose-bisphosphate aldolase activity
ASA_3505	COG0126	phosphoglycerate kinase activity
ASA_3506	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASA_3507	COG1940	carbohydrate kinase activity
ASA_3510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ASA_3517	COG0840	transmembrane signaling receptor activity
ASA_3520	COG0529	Catalyzes the synthesis of activated sulfate
ASA_3521	COG0471	metal ion transport
ASA_3521	COG3273	potassium ion transport
ASA_3522	COG2895	sulfate adenylyltransferase (ATP) activity
ASA_3523	COG0175	sulfate reduction
ASA_3524	COG1648	precorrin-2 dehydrogenase activity
ASA_3524	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASA_3525	COG0330	HflC and HflK could
ASA_3526	COG1585	Membrane protein implicated in regulation of membrane protease activity
ASA_3527	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASA_3527	COG0517	IMP dehydrogenase activity
ASA_3528	COG0488	(ABC) transporter
ASA_3530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ASA_3544	COG0789	Transcriptional regulator
ASA_3546	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASA_3547	COG1376	ErfK ybiS ycfS ynhG family protein
ASA_3548	COG0668	transmembrane transport
ASA_3550	COG2731	YhcH YjgK YiaL family protein
ASA_3552	COG1794	racemase activity, acting on amino acids and derivatives
ASA_3560	COG0733	neurotransmitter:sodium symporter activity
ASA_3562	COG0733	neurotransmitter:sodium symporter activity
ASA_3565	COG0561	phosphatase activity
ASA_3571	COG1846	Transcriptional regulator
ASA_3572	COG1764	response to oxidative stress
ASA_3573	COG2130	NADP-dependent
ASA_3574	COG0494	nUDIX hydrolase
ASA_3577	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASA_3578	COG1349	DNA-binding transcription factor activity
ASA_3580	COG1028	Short-chain dehydrogenase reductase Sdr
ASA_3583	COG3730	PTS system glucitol sorbitol-specific
ASA_3588	COG2982	Protein involved in outer membrane biogenesis
ASA_3589	COG1505	serine-type exopeptidase activity
ASA_3590	COG1136	(ABC) transporter
ASA_3590	COG0577	efflux transmembrane transporter activity
ASA_3591	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASA_3592	COG0745	RESPONSE REGULATOR receiver
ASA_3593	COG2205	protein histidine kinase activity
ASA_3594	COG2816	NAD+ diphosphatase activity
ASA_3606	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
ASA_3610	COG0513	Belongs to the DEAD box helicase family
ASA_3616	COG2957	Belongs to the agmatine deiminase family
ASA_3618	COG4221	oxidoreductase activity
ASA_3621	COG1024	Enoyl-CoA hydratase
ASA_3623	COG0110	maltose O-acetyltransferase activity
ASA_3625	COG4166	transmembrane transport
ASA_3628	COG1872	DUF167
ASA_3629	COG0762	integral membrane protein
ASA_3630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASA_3631	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ASA_3634	COG3022	response to hydroperoxide
ASA_3635	COG0513	Belongs to the DEAD box helicase family
ASA_3636	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ASA_3640	COG0735	belongs to the Fur family
ASA_3641	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASA_3644	COG0776	regulation of translation
ASA_3645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ASA_3650	COG0560	Phosphoserine phosphatase
ASA_3652	COG0813	purine-nucleoside phosphorylase activity
ASA_3653	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ASA_3654	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ASA_3655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASA_3657	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASA_3658	COG0084	hydrolase, TatD family'
ASA_3662	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASA_3663	COG0004	ammonium transporteR
ASA_3674	COG3561	AntA/AntB antirepressor
ASA_3678	COG1965	Belongs to the frataxin family
ASA_3679	COG0019	diaminopimelate decarboxylase activity
ASA_3680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASA_3683	COG1011	Hydrolase
ASA_3685	COG0668	transmembrane transport
ASA_3687	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ASA_3688	COG0561	phosphatase activity
ASA_3691	COG0842	Transport permease protein
ASA_3691	COG1129	ABC transporter
ASA_3693	COG1546	Belongs to the CinA family
ASA_3693	COG1058	Belongs to the CinA family
ASA_3694	COG1418	mRNA catabolic process
ASA_3695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ASA_3697	COG1522	sequence-specific DNA binding
ASA_3698	COG1368	sulfuric ester hydrolase activity
ASA_3702	COG1285	pathogenesis
ASA_3706	COG4221	oxidoreductase activity
ASA_3710	COG1979	alcohol dehydrogenase
ASA_3712	COG2873	o-acetylhomoserine
ASA_3714	COG4533	DNA binding
ASA_3715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ASA_3718	COG5380	lipid catabolic process
ASA_3719	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ASA_3722	COG2949	membrane
ASA_3723	COG3291	Pkd domain containing protein
ASA_3725	COG3539	Fimbrial protein
ASA_3727	COG3188	usher protein
ASA_3728	COG3121	Chaperone
ASA_3729	COG3539	Fimbrial protein
ASA_3733	COG0318	PFAM AMP-dependent synthetase and ligase
ASA_3735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ASA_3736	COG0596	Alpha beta hydrolase
ASA_3737	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASA_3738	COG1169	isochorismate synthase
ASA_3739	COG1575	Belongs to the MenA family. Type 1 subfamily
ASA_3744	COG0513	Belongs to the DEAD box helicase family
ASA_3745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASA_3746	COG1988	membrane-bound metal-dependent
ASA_3749	COG1671	Belongs to the UPF0178 family
ASA_3753	COG0484	heat shock protein binding
ASA_3754	COG3263	regulation of cellular component size
ASA_3755	COG3722	fumarate hydratase activity
ASA_3756	COG0246	Mannitol dehydrogenase
ASA_3757	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_3757	COG2213	PTS system mannitol-specific
ASA_3760	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ASA_3763	COG2771	luxR family
ASA_3766	COG3133	Outer membrane lipoprotein
ASA_3767	COG0456	acetyltransferase
ASA_3771	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ASA_3772	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ASA_3776	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASA_3777	COG1459	type II secretion system
ASA_3778	COG2165	general secretion pathway protein
ASA_3780	COG2165	general secretion pathway protein
ASA_3781	COG4795	General secretion pathway protein
ASA_3782	COG3156	type II secretion system protein K
ASA_3784	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ASA_3787	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASA_3788	COG1011	Hydrolase
ASA_3789	COG0494	nUDIX hydrolase
ASA_3790	COG1218	3'(2'),5'-bisphosphate nucleotidase
ASA_3791	COG0814	amino acid
ASA_3792	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASA_3795	COG0626	cystathionine gamma-synthase activity
ASA_3796	COG0527	aspartate kinase activity
ASA_3796	COG0460	homoserine dehydrogenase
ASA_3799	COG1346	cytolysis
ASA_3800	COG1380	Effector of murein hydrolase LrgA
ASA_3807	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASA_3808	COG1546	Belongs to the CinA family
ASA_3809	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASA_3811	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASA_3812	COG0527	aspartate kinase activity
ASA_3813	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ASA_3818	COG1686	Belongs to the peptidase S11 family
ASA_3819	COG0586	Pfam SNARE associated Golgi protein
ASA_3820	COG1253	flavin adenine dinucleotide binding
ASA_3822	COG2927	DNA polymerase III (CHI subunit)
ASA_3823	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASA_3824	COG0795	lipopolysaccharide-transporting ATPase activity
ASA_3825	COG0795	lipopolysaccharide-transporting ATPase activity
ASA_3854	COG4695	Portal protein
ASA_3870	COG2932	Transcriptional regulator
ASA_3871	COG4974	Belongs to the 'phage' integrase family
ASA_3872	COG0582	viral genome integration into host DNA
ASA_3874	COG3072	Adenylate cyclase
ASA_3875	COG0181	hydroxymethylbilane synthase activity
ASA_3877	COG2959	enzyme of heme biosynthesis
ASA_3880	COG1494	fructose-1,6-bisphosphatase
ASA_3890	COG3932	Exopolysaccharide synthesis, ExoD
ASA_3891	COG0814	amino acid
ASA_3894	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ASA_3895	COG0110	maltose O-acetyltransferase activity
ASA_3901	COG2022	thiamine diphosphate biosynthetic process
ASA_3903	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASA_3904	COG0352	thiamine-phosphate diphosphorylase activity
ASA_3905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASA_3909	COG0745	RESPONSE REGULATOR receiver
ASA_3911	COG0189	ligase activity
ASA_3917	COG1639	'signal transduction protein
ASA_3919	COG3700	Belongs to the class B bacterial acid phosphatase family
ASA_3921	COG1366	Belongs to the anti-sigma-factor antagonist family
ASA_3922	COG2172	sigma factor antagonist activity
ASA_3923	COG2205	protein histidine kinase activity
ASA_3923	COG0784	Response regulator, receiver
ASA_3923	COG5002	protein histidine kinase activity
ASA_3924	COG3437	response regulator, receiver
ASA_3929	COG0312	modulator of DNA gyrase
ASA_3930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASA_3932	COG3164	Protein of unknown function
ASA_3933	COG1530	ribonuclease E activity
ASA_3934	COG0424	maF-like protein
ASA_3935	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ASA_3936	COG1792	Involved in formation and maintenance of cell shape
ASA_3937	COG1077	Cell shape determining protein MreB Mrl
ASA_3949	COG2200	EAL domain
ASA_3949	COG2199	diguanylate cyclase activity
ASA_3951	COG0387	Pfam Sodium calcium exchanger
ASA_3952	COG2986	histidine ammonia-lyase
ASA_3953	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASA_3954	COG0010	Belongs to the arginase family
ASA_3955	COG1228	amidohydrolase
ASA_3956	COG2188	Transcriptional regulator
ASA_3957	COG0288	reversible hydration of carbon dioxide
ASA_3959	COG2177	Part of the ABC transporter FtsEX involved in
ASA_3960	COG2884	Cell division ATP-binding protein ftsE
ASA_3961	COG0552	protein localization to endoplasmic reticulum
ASA_3962	COG0742	ribosomal rna small subunit methyltransferase
ASA_3967	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASA_3968	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ASA_3970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASA_3972	COG2095	MarC family integral membrane protein
ASA_3974	COG1301	dicarboxylic acid transport
ASA_3979	COG3714	YhhN family
ASA_3983	COG1770	oligopeptidase
ASA_3986	COG2249	NAD(P)H dehydrogenase (quinone) activity
ASA_3994	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ASA_3998	COG2197	response regulator
ASA_3999	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASA_4001	COG1278	Cold shock
ASA_4003	COG3706	GGDEF domain
ASA_4004	COG2205	protein histidine kinase activity
ASA_4005	COG0745	RESPONSE REGULATOR receiver
ASA_4010	COG0840	transmembrane signaling receptor activity
ASA_4012	COG0745	RESPONSE REGULATOR receiver
ASA_4012	COG3706	GGDEF domain
ASA_4013	COG0347	Belongs to the P(II) protein family
ASA_4014	COG0004	ammonium transporteR
ASA_4018	COG0346	lactoylglutathione lyase activity
ASA_4020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASA_4021	COG1074	ATP-dependent DNA helicase activity
ASA_4022	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ASA_4023	COG2259	Doxx family
ASA_4024	COG1741	Belongs to the pirin family
ASA_4031	COG1176	ABC-type spermidine putrescine transport system, permease component I
ASA_4033	COG3842	ATPase activity
ASA_4035	COG2199	diguanylate cyclase activity
ASA_4035	COG2203	Gaf domain
ASA_4040	COG0753	catalase activity
ASA_4045	COG0494	nUDIX hydrolase
ASA_4046	COG0628	permease
ASA_4047	COG3284	Transcriptional regulator
ASA_4049	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ASA_4049	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASA_4049	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_4050	COG1461	Dihydroxyacetone kinase
ASA_4051	COG2376	Dihydroxyacetone kinase
ASA_4053	COG4584	PFAM Integrase catalytic
ASA_4054	COG1484	DNA-dependent DNA replication
ASA_4061	COG0203	ribosomal protein L17
ASA_4062	COG0202	RNA polymerase activity
ASA_4063	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASA_4064	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASA_4065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASA_4066	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASA_4067	COG0201	protein transport
ASA_4068	COG0200	Binds to the 23S rRNA
ASA_4069	COG1841	ribosomal large subunit assembly
ASA_4070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASA_4071	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASA_4072	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASA_4073	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASA_4074	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASA_4075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASA_4076	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASA_4077	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASA_4078	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASA_4079	COG0255	Belongs to the universal ribosomal protein uL29 family
ASA_4080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASA_4081	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASA_4082	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASA_4083	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASA_4084	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASA_4085	COG0089	rRNA binding
ASA_4086	COG0088	Forms part of the polypeptide exit tunnel
ASA_4087	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASA_4088	COG0051	transcription antitermination factor activity, RNA binding
ASA_4091	COG0745	RESPONSE REGULATOR receiver
ASA_4092	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASA_4094	COG2183	response to ionizing radiation
ASA_4098	COG0596	Alpha beta hydrolase
ASA_4099	COG1040	competence protein
ASA_4100	COG0316	Belongs to the HesB IscA family
ASA_4100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ASA_4101	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASA_4102	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ASA_4103	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASA_4104	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ASA_4105	COG4942	peptidase
ASA_4107	COG1609	Transcriptional regulator
ASA_4108	COG0800	Aldolase
ASA_4109	COG0129	dihydroxy-acid dehydratase activity
ASA_4110	COG3265	gluconokinase activity
ASA_4111	COG2610	gluconate transmembrane transporter activity
ASA_4112	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASA_4113	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ASA_4115	COG0456	acetyltransferase
ASA_4118	COG1295	ribonuclease BN
ASA_4120	COG0174	glutamine synthetase
ASA_4122	COG3852	Histidine kinase
ASA_4123	COG2204	response regulator
ASA_4124	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASA_4125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASA_4127	COG3078	GTPase activator activity
ASA_4129	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ASA_4132	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASA_4133	COG0408	coproporphyrinogen oxidase activity
ASA_4134	COG0009	L-threonylcarbamoyladenylate synthase
ASA_4136	COG0551	DNA topoisomerase type I activity
ASA_4137	COG2922	Belongs to the Smg family
ASA_4138	COG0758	DNA mediated transformation
ASA_4139	COG1652	LysM domain
ASA_4140	COG0242	peptide deformylase activity
ASA_4141	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASA_4142	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASA_4142	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASA_4143	COG0569	domain protein
ASA_4144	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASA_4145	COG1322	Protein conserved in bacteria
ASA_4149	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASA_4150	COG0686	Belongs to the AlaDH PNT family
ASA_4151	COG0519	Catalyzes the synthesis of GMP from XMP
ASA_4151	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASA_4155	COG1012	belongs to the aldehyde dehydrogenase family
ASA_4157	COG2962	Rard protein
ASA_4159	COG1280	lysine exporter protein (LysE YggA)
ASA_4161	COG2391	methyltransferase activity
ASA_4162	COG1280	lysine exporter protein (LysE YggA)
ASA_4163	COG0583	DNA-binding transcription factor activity
ASA_4167	COG2823	Periplasmic or secreted lipoprotein
ASA_4174	COG0210	DNA helicase
ASA_4179	COG0583	DNA-binding transcription factor activity
ASA_4183	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ASA_4184	COG0385	Bile acid
ASA_4193	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ASA_4195	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ASA_4196	COG3074	FtsZ-dependent cytokinesis
ASA_4198	COG1045	serine acetyltransferase
ASA_4200	COG0745	RESPONSE REGULATOR receiver
ASA_4201	COG2205	protein histidine kinase activity
ASA_4202	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASA_4206	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASA_4207	COG2937	Belongs to the GPAT DAPAT family
ASA_4208	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASA_4209	COG3161	chorismate lyase activity
ASA_4210	COG1580	Controls the rotational direction of flagella during chemotaxis
ASA_4215	COG1609	Transcriptional regulator
ASA_4216	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASA_4219	COG1519	Transferase
ASA_4220	COG0859	PFAM glycosyl transferase family 9
ASA_4221	COG0463	Glycosyl transferase, family 2
ASA_4222	COG0859	PFAM glycosyl transferase family 9
ASA_4223	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASA_4224	COG2990	Protein conserved in bacteria
ASA_4225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASA_4227	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASA_4228	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASA_4229	COG2003	Belongs to the UPF0758 family
ASA_4230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASA_4231	COG0756	dUTP diphosphatase activity
ASA_4232	COG1309	transcriptional regulator
ASA_4233	COG0668	transmembrane transport
ASA_4235	COG0166	Belongs to the GPI family
ASA_4236	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASA_4237	COG0583	DNA-binding transcription factor activity
ASA_4245	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ASA_4246	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASA_4247	COG1739	Uncharacterized protein family UPF0029
ASA_4248	COG0006	proline dipeptidase activity
ASA_4249	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASA_4250	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASA_4250	COG1024	Enoyl-CoA hydratase
ASA_4251	COG0183	Belongs to the thiolase family
ASA_4252	COG0745	RESPONSE REGULATOR receiver
ASA_4253	COG2205	protein histidine kinase activity
ASA_4256	COG0425	Belongs to the sulfur carrier protein TusA family
ASA_4257	COG0251	oxidation-reduction process
ASA_4258	COG2885	chlorophyll binding
ASA_4259	COG2818	Glycosylase
ASA_4260	COG0752	glycyl-tRNA synthetase alpha subunit
ASA_4261	COG0751	glycine-tRNA ligase activity
ASA_4263	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASA_4265	COG2202	Pas domain
ASA_4265	COG2200	EAL domain
ASA_4265	COG2199	diguanylate cyclase activity
ASA_4268	COG0814	amino acid
ASA_4269	COG0348	domain, Protein
ASA_4271	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASA_4272	COG0426	domain, Protein
ASA_4272	COG1773	rubredoxin
ASA_4273	COG3604	Transcriptional regulator
ASA_4274	COG2188	Transcriptional regulator
ASA_4278	COG1609	Transcriptional regulator
ASA_4280	COG0559	Belongs to the binding-protein-dependent transport system permease family
ASA_4286	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASA_4291	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASA_4293	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ASA_4294	COG3118	belongs to the thioredoxin family
ASA_4295	COG0513	Belongs to the DEAD box helicase family
ASA_4296	COG0248	Ppx GppA phosphatase
ASA_4298	COG0742	ribosomal rna small subunit methyltransferase
ASA_4299	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASA_4303	COG0084	hydrolase, TatD family'
ASA_4304	COG0805	protein transport
ASA_4305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASA_4307	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASA_4308	COG3165	ubiquinone biosynthetic process from chorismate
ASA_4310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASA_4319	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ASA_4320	COG0848	biopolymer transport protein
ASA_4321	COG0811	peptide transport
ASA_4322	COG0811	peptide transport
ASA_4324	COG2771	luxR family
ASA_4326	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASA_4329	COG1484	DNA-dependent DNA replication
ASA_4330	COG4584	PFAM Integrase catalytic
ASA_4337	COG2801	Transposase and inactivated derivatives
ASA_4342	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASA_4343	COG1349	DNA-binding transcription factor activity
ASA_4344	COG0745	RESPONSE REGULATOR receiver
ASA_4345	COG2205	protein histidine kinase activity
ASA_4347	COG4452	Inner membrane protein CreD
ASA_4348	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASA_4349	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASA_4350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASA_4351	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASA_4352	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASA_4353	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASA_4354	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASA_4356	COG0356	it plays a direct role in the translocation of protons across the membrane
ASA_4357	COG3312	ion transport
ASA_4358	COG1475	DNA binding
ASA_4359	COG1192	Involved in chromosome partitioning
ASA_4360	COG0357	Ribosomal RNA small subunit methyltransferase G
ASA_4361	COG0445	tRNA wobble uridine modification
ASA_4362	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASA_4363	COG4774	siderophore transport
ASA_4364	COG4615	Cyclic peptide transporter
ASA_4365	COG1120	ATPase activity
ASA_4366	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASA_4368	COG4774	siderophore transport
ASA_4369	COG4607	ABC-type enterochelin transport system periplasmic component
ASA_4370	COG4604	ABC transporter, ATP-binding protein
ASA_4371	COG4605	iron ion homeostasis
ASA_4372	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASA_4376	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASA_4378	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASA_4381	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ASA_4382	COG0706	membrane insertase activity
ASA_4383	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ASA_4384	COG0594	ribonuclease P activity
ASA_4385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ASA_P4G001	COG4584	PFAM Integrase catalytic
ASA_P4G002	COG1484	DNA-dependent DNA replication
ASA_P4G025	COG1192	Involved in chromosome partitioning
ASA_P4G030	COG0776	regulation of translation
ASA_P4G031	COG1525	nuclease
ASA_P4G040	COG2974	May be involved in recombination
ASA_P4G072	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASA_P4G080	COG3501	Rhs element vgr protein
ASA_P4G085	COG4584	PFAM Integrase catalytic
ASA_P4G094	COG3300	MHYT domain
ASA_P4G094	COG5001	Diguanylate cyclase
ASA_P4G110	COG3550	peptidyl-serine autophosphorylation
ASA_P4G111	COG1396	sequence-specific DNA binding
ASA_P4G112	COG4974	Belongs to the 'phage' integrase family
ASA_P4G141	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASA_P4G151	COG5433	transposase activity
ASA_P4G164	COG5433	transposase activity
ASA_P4G171	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASA_P4G174	COG1002	Type II restriction enzyme, methylase subunits
ASA_P4G175	COG1061	Type III restriction enzyme res subunit
ASA_P4G176	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ASA_P5G002	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASA_P5G004	COG1192	Involved in chromosome partitioning
ASA_P5G006	COG3328	transposase activity
ASA_P5G011	COG0393	Putative heavy-metal-binding
ASA_P5G018	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASA_P5G021	COG1192	Involved in chromosome partitioning
ASA_P5G044	COG3328	transposase activity
ASA_P5G048	COG1317	bacterial-type flagellum organization
ASA_P5G066	COG0457	Tetratricopeptide repeat
ASA_P5G079	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASA_P5G080	COG4790	Type iii secretion
ASA_P5G081	COG4794	Type iii secretion
ASA_P5G082	COG4791	protein targeting
ASA_P5G083	COG4792	protein secretion
ASA_P5G090	COG3328	transposase activity
ASA_P5G091	COG1484	DNA-dependent DNA replication
ASA_P5G092	COG4584	PFAM Integrase catalytic
ASA_P5G116	COG2801	Transposase and inactivated derivatives
ASA_P5G123	COG3318	Belongs to the UPF0149 family
ASA_P5G123	COG3012	SEC-C Motif Domain Protein
ASA_P5G127	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASA_P5G141	COG2003	Belongs to the UPF0758 family
ASA_P5G148	COG4584	PFAM Integrase catalytic
ASA_P5G149	COG1484	DNA-dependent DNA replication
ASA_P5G154	COG2801	Transposase and inactivated derivatives
ASA_P5G157	COG2194	sulfuric ester hydrolase activity
ASA_P5G158	COG2194	sulfuric ester hydrolase activity
ASA_P5G160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs