locus-tag	class	description
PI860_00160	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
PI860_00185	COG0322	excinuclease ABC activity
PI860_00190	COG2197	response regulator
PI860_00195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PI860_00200	COG2835	tetraacyldisaccharide 4'-kinase activity
PI860_00205	COG1663	tetraacyldisaccharide 4'-kinase activity
PI860_00210	COG1132	(ABC) transporter
PI860_00215	COG0658	competence protein
PI860_00215	COG2333	competence protein COMEC
PI860_00230	COG0433	COG0433 Predicted ATPase
PI860_00235	COG1448	Aminotransferase
PI860_00250	COG1199	ATP-dependent helicase activity
PI860_00260	COG0123	including yeast histone deacetylase and acetoin utilization protein
PI860_00265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PI860_00270	COG1785	Belongs to the alkaline phosphatase family
PI860_00290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PI860_00305	COG2271	Major facilitator Superfamily
PI860_00310	COG3706	GGDEF domain
PI860_00315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_00320	COG0765	amino acid transport
PI860_00325	COG1126	abc transporter atp-binding protein
PI860_00335	COG0531	amino acid
PI860_00350	COG1253	flavin adenine dinucleotide binding
PI860_00355	COG0704	Plays a role in the regulation of phosphate uptake
PI860_00360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PI860_00365	COG0581	inorganic phosphate transmembrane transporter activity
PI860_00370	COG0573	inorganic phosphate transmembrane transporter activity
PI860_00375	COG0590	tRNA wobble adenosine to inosine editing
PI860_00390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PI860_00410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PI860_00415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PI860_00420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PI860_00425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PI860_00455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PI860_00460	COG0248	Ppx GppA phosphatase
PI860_00465	COG2239	Acts as a magnesium transporter
PI860_00485	COG1706	bacterial-type flagellum-dependent cell motility
PI860_00490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PI860_00500	COG4787	bacterial-type flagellum-dependent cell motility
PI860_00520	COG1815	bacterial-type flagellum-dependent cell motility
PI860_00530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PI860_00535	COG0835	chemotaxis
PI860_00535	COG0784	Response regulator, receiver
PI860_00555	COG0622	Phosphoesterase
PI860_00560	COG4166	transmembrane transport
PI860_00615	COG1278	Cold shock
PI860_00655	COG1484	DNA-dependent DNA replication
PI860_00660	COG4584	PFAM Integrase catalytic
PI860_00675	COG3132	Protein of unknown function, DUF480
PI860_00685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PI860_00700	COG0438	transferase activity, transferring glycosyl groups
PI860_00735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PI860_00750	COG0471	metal ion transport
PI860_00750	COG0490	domain, Protein
PI860_00755	COG3273	potassium ion transport
PI860_00755	COG0471	metal ion transport
PI860_00775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PI860_00780	COG0438	transferase activity, transferring glycosyl groups
PI860_00800	COG1450	Type ii and iii secretion system protein
PI860_00845	COG1459	type II secretion system
PI860_00850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PI860_00870	COG1091	dTDP-4-dehydrorhamnose reductase activity
PI860_00890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI860_00895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_00900	COG1309	transcriptional regulator
PI860_00920	COG1946	Acyl-CoA thioesterase
PI860_00930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PI860_00940	COG0009	L-threonylcarbamoyladenylate synthase
PI860_00950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PI860_00955	COG0512	Glutamine amidotransferase of anthranilate synthase
PI860_00955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PI860_00960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PI860_00965	COG0134	indole-3-glycerol-phosphate synthase activity
PI860_00965	COG0135	phosphoribosylanthranilate isomerase activity
PI860_00970	COG0133	tryptophan synthase activity
PI860_00975	COG0159	tryptophan synthase activity
PI860_01000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PI860_01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_01000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PI860_01010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PI860_01030	COG0482	sulfurtransferase activity
PI860_01035	COG2915	High frequency lysogenization protein hflD homolog
PI860_01040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PI860_01045	COG2850	peptidyl-arginine hydroxylation
PI860_01065	COG3153	acetyltransferase
PI860_01085	COG0259	pyridoxamine-phosphate oxidase activity
PI860_01100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PI860_01100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI860_01105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PI860_01125	COG3088	subunit of a heme lyase
PI860_01125	COG4235	cytochrome complex assembly
PI860_01130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PI860_01135	COG1138	Cytochrome C-type biogenesis protein
PI860_01140	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PI860_01145	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PI860_01150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PI860_01155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PI860_01175	COG0835	chemotaxis
PI860_01185	COG1192	Involved in chromosome partitioning
PI860_01190	COG1360	Flagellar Motor Protein
PI860_01195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PI860_01200	COG2201	protein-glutamate methylesterase activity
PI860_01205	COG2198	Histidine kinase
PI860_01205	COG0643	Histidine kinase
PI860_01205	COG0784	Response regulator, receiver
PI860_01210	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PI860_01235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PI860_01245	COG1684	flagellar biosynthetic protein fliR
PI860_01300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PI860_01310	COG1677	Flagellar hook-basal body complex protein FliE
PI860_01320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PI860_01335	COG1342	Belongs to the UPF0251 family
PI860_01355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PI860_01380	COG1737	Transcriptional regulator
PI860_01385	COG0469	pyruvate kinase activity
PI860_01395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI860_01400	COG1960	acyl-CoA dehydrogenase activity
PI860_01410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PI860_01445	COG3209	COG3209 Rhs family protein
PI860_01455	COG1484	DNA-dependent DNA replication
PI860_01460	COG4584	PFAM Integrase catalytic
PI860_01490	COG1376	ErfK ybiS ycfS ynhG family protein
PI860_01490	COG1388	LysM domain
PI860_01505	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PI860_01510	COG0791	NLP P60 protein
PI860_01515	COG2091	lysine biosynthetic process via aminoadipic acid
PI860_01520	COG3118	belongs to the thioredoxin family
PI860_01530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI860_01535	COG0788	formyltetrahydrofolate deformylase activity
PI860_01545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PI860_01565	COG0366	Alpha amylase catalytic
PI860_01570	COG0739	heme binding
PI860_01570	COG1196	nuclear chromosome segregation
PI860_01570	COG0741	lytic transglycosylase activity
PI860_01575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PI860_01580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PI860_01585	COG0673	inositol 2-dehydrogenase activity
PI860_01615	COG1032	radical SAM domain protein
PI860_01625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI860_01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_01635	COG3706	GGDEF domain
PI860_01640	COG1752	Esterase of the alpha-beta hydrolase superfamily
PI860_01645	COG0733	neurotransmitter:sodium symporter activity
PI860_01675	COG0281	malic enzyme
PI860_01680	COG2207	Transcriptional regulator
PI860_01685	COG0534	Mate efflux family protein
PI860_01700	COG2233	PERMEase
PI860_01705	COG0095	Lipoate-protein ligase
PI860_01710	COG1115	amino acid carrier protein
PI860_01715	COG0019	diaminopimelate decarboxylase activity
PI860_01755	COG1131	(ABC) transporter
PI860_01760	COG0545	Peptidyl-prolyl cis-trans isomerase
PI860_01765	COG3142	Participates in the control of copper homeostasis
PI860_01770	COG1940	carbohydrate kinase activity
PI860_01790	COG5002	protein histidine kinase activity
PI860_01795	COG0745	RESPONSE REGULATOR receiver
PI860_01800	COG0346	lactoylglutathione lyase activity
PI860_01805	COG3706	GGDEF domain
PI860_01835	COG3290	protein histidine kinase activity
PI860_01840	COG0281	malic enzyme
PI860_01855	COG1846	Transcriptional regulator
PI860_01860	COG1566	PFAM secretion protein HlyD family protein
PI860_01885	COG0602	queuosine metabolic process
PI860_01895	COG1328	CTP reductase activity
PI860_01905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PI860_01910	COG3115	cell septum assembly
PI860_01915	COG1196	nuclear chromosome segregation
PI860_01925	COG2860	membrane
PI860_01935	COG3108	Peptidase M15
PI860_01940	COG2989	Protein conserved in bacteria
PI860_01955	COG0463	Glycosyl transferase, family 2
PI860_01970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PI860_01975	COG0739	heme binding
PI860_01980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PI860_01995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PI860_02005	COG3091	SprT-like family
PI860_02015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PI860_02020	COG0189	ligase activity
PI860_02035	COG1678	Uncharacterized ACR, COG1678
PI860_02040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PI860_02060	COG0714	Associated with various cellular activities
PI860_02075	COG1115	amino acid carrier protein
PI860_02080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PI860_02095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PI860_02115	COG1301	dicarboxylic acid transport
PI860_02135	COG2890	protein-(glutamine-N5) methyltransferase activity
PI860_02140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PI860_02145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PI860_02150	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PI860_02155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PI860_02165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PI860_02170	COG0737	Belongs to the 5'-nucleotidase family
PI860_02175	COG0193	aminoacyl-tRNA hydrolase activity
PI860_02180	COG0012	GTP binding
PI860_02245	COG0490	domain, Protein
PI860_02245	COG0471	metal ion transport
PI860_02255	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PI860_02285	COG0443	Heat shock 70 kDa protein
PI860_02295	COG0366	Alpha amylase catalytic
PI860_02305	COG0488	(ABC) transporter
PI860_02315	COG0674	pyruvate-flavodoxin oxidoreductase activity
PI860_02315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PI860_02315	COG1013	pyruvate-flavodoxin oxidoreductase activity
PI860_02315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_02325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PI860_02335	COG1012	belongs to the aldehyde dehydrogenase family
PI860_02345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PI860_02360	COG0180	Tryptophanyl-tRNA synthetase
PI860_02365	COG0546	phosphoglycolate phosphatase activity
PI860_02370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PI860_02375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PI860_02385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PI860_02390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PI860_02420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PI860_02425	COG0583	DNA-binding transcription factor activity
PI860_02445	COG0583	DNA-binding transcription factor activity
PI860_02460	COG0739	heme binding
PI860_02475	COG1511	domain protein
PI860_02475	COG3264	Mechanosensitive ion channel
PI860_02480	COG0584	glycerophosphoryl diester phosphodiesterase
PI860_02490	COG1053	succinate dehydrogenase
PI860_02495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PI860_02500	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PI860_02505	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PI860_02525	COG3214	Protein conserved in bacteria
PI860_02565	COG0642	Histidine kinase
PI860_02575	COG0516	GMP reductase activity
PI860_02585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PI860_02595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PI860_02615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PI860_02630	COG3706	GGDEF domain
PI860_02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI860_02645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PI860_02650	COG1702	phosphate starvation-inducible protein PhoH
PI860_02655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PI860_02660	COG4535	Mg2 and Co2 transporter CorC
PI860_02665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PI860_02670	COG2888	peptidyl-tyrosine sulfation
PI860_02675	COG0495	leucyl-tRNA aminoacylation
PI860_02695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PI860_02700	COG0799	negative regulation of ribosome biogenesis
PI860_02705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PI860_02710	COG0768	penicillin binding
PI860_02715	COG0772	Belongs to the SEDS family
PI860_02725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PI860_02730	COG1686	Belongs to the peptidase S11 family
PI860_02735	COG2921	Belongs to the UPF0250 family
PI860_02740	COG0321	lipoyl(octanoyl) transferase activity
PI860_02745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PI860_02760	COG3621	Patatin-like phospholipase
PI860_02785	COG1484	DNA-dependent DNA replication
PI860_02790	COG4584	PFAM Integrase catalytic
PI860_02825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PI860_02830	COG3545	Serine hydrolase
PI860_02845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PI860_02855	COG1970	mechanosensitive ion channel activity
PI860_02865	COG4974	Belongs to the 'phage' integrase family
PI860_02880	COG0312	modulator of DNA gyrase
PI860_02935	COG1422	Protein of unknown function (DUF1090)
PI860_02940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PI860_02945	COG3706	GGDEF domain
PI860_02955	COG1185	polyribonucleotide nucleotidyltransferase activity
PI860_02960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PI860_02965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PI860_02970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PI860_02975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PI860_02980	COG0195	Participates in both transcription termination and antitermination
PI860_02985	COG0779	Required for maturation of 30S ribosomal subunits
PI860_03000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PI860_03005	COG0149	triose-phosphate isomerase activity
PI860_03010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PI860_03015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PI860_03025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PI860_03030	COG1534	Rna-binding protein
PI860_03065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PI860_03070	COG1722	exodeoxyribonuclease VII activity
PI860_03075	COG0142	geranyltranstransferase activity
PI860_03080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PI860_03090	COG0601	transmembrane transport
PI860_03100	COG4172	Belongs to the ABC transporter superfamily
PI860_03105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PI860_03110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PI860_03115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI860_03120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PI860_03135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PI860_03135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PI860_03140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PI860_03155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PI860_03170	COG3381	protein complex oligomerization
PI860_03200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI860_03205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PI860_03210	COG0511	ligase activity, forming carbon-carbon bonds
PI860_03215	COG0439	Biotin carboxylase
PI860_03220	COG3924	membrane
PI860_03225	COG4145	pantothenate transmembrane transporter activity
PI860_03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PI860_03230	COG2190	(PTS) system
PI860_03230	COG1263	PTS System
PI860_03235	COG0583	DNA-binding transcription factor activity
PI860_03240	COG0604	alcohol dehydrogenase
PI860_03245	COG2264	protein methyltransferase activity
PI860_03255	COG4303	Ethanolamine ammonia lyase large subunit
PI860_03260	COG4302	ethanolamine ammonia-lyase activity
PI860_03285	COG0778	Nitroreductase
PI860_03290	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI860_03290	COG1902	pentaerythritol trinitrate reductase activity
PI860_03295	COG0616	signal peptide processing
PI860_03315	COG3139	Protein of unknown function (DUF1315)
PI860_03320	COG0252	asparaginase activity
PI860_03325	COG0786	glutamate:sodium symporter activity
PI860_03340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PI860_03345	COG0384	phenazine biosynthesis protein PhzF
PI860_03360	COG0175	sulfate reduction
PI860_03365	COG2113	Glycine betaine
PI860_03370	COG4176	ABC-type proline glycine betaine transport system permease component
PI860_03375	COG4175	Glycine betaine
PI860_03385	COG3610	response to peptide
PI860_03395	COG2966	Psort location CytoplasmicMembrane, score
PI860_03405	COG0521	Mo-molybdopterin cofactor biosynthetic process
PI860_03415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PI860_03420	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_03430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PI860_03455	COG2986	histidine ammonia-lyase
PI860_03470	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PI860_03485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PI860_03520	COG1858	cytochrome C peroxidase
PI860_03530	COG2313	pseudouridylate synthase activity
PI860_03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PI860_03535	COG1522	sequence-specific DNA binding
PI860_03565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PI860_03570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PI860_03580	COG1073	alpha beta
PI860_03585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PI860_03595	COG2195	Cleaves the N-terminal amino acid of tripeptides
PI860_03600	COG4608	Belongs to the ABC transporter superfamily
PI860_03605	COG0444	Belongs to the ABC transporter superfamily
PI860_03610	COG0747	negative chemotaxis
PI860_03615	COG4239	(ABC) transporter, permease
PI860_03620	COG4174	ABC transporter (Permease)
PI860_03625	COG0601	transmembrane transport
PI860_03630	COG4206	TonB-dependent receptor
PI860_03640	COG0811	peptide transport
PI860_03645	COG0811	peptide transport
PI860_03650	COG0848	biopolymer transport protein
PI860_03695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI860_03700	COG0840	transmembrane signaling receptor activity
PI860_03710	COG1278	Cold shock
PI860_03740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PI860_03750	COG0688	phosphatidylethanolamine metabolic process
PI860_03755	COG4628	conserved protein (DUF2132)
PI860_03775	COG3300	MHYT domain
PI860_03775	COG5001	Diguanylate cyclase
PI860_03780	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PI860_03815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PI860_03820	COG1012	belongs to the aldehyde dehydrogenase family
PI860_03830	COG1132	(ABC) transporter
PI860_03840	COG2897	thiosulfate sulfurtransferase activity
PI860_03845	COG2066	Belongs to the glutaminase family
PI860_03850	COG3171	Protein conserved in bacteria
PI860_03855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PI860_03870	COG2200	EAL domain
PI860_03875	COG1090	epimerase
PI860_03880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PI860_03885	COG4181	ATPase activity
PI860_03890	COG2755	lipolytic protein G-D-S-L family
PI860_03895	COG0835	chemotaxis
PI860_03895	COG0784	Response regulator, receiver
PI860_03905	COG0569	domain protein
PI860_03905	COG2985	domain, Protein
PI860_03910	COG1272	protein, Hemolysin III
PI860_03915	COG0076	glutamate decarboxylase activity
PI860_03920	COG2917	probably involved in intracellular septation
PI860_03925	COG2350	Protein conserved in bacteria
PI860_03935	COG1555	photosystem II stabilization
PI860_03940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PI860_03945	COG3104	oligopeptide transport
PI860_03950	COG0745	RESPONSE REGULATOR receiver
PI860_03980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_03995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PI860_04000	COG1280	lysine exporter protein (LysE YggA)
PI860_04030	COG0316	Belongs to the HesB IscA family
PI860_04040	COG0038	chloride channel
PI860_04045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PI860_04060	COG0671	phosphoesterase, PA-phosphatase related
PI860_04070	COG3437	response regulator, receiver
PI860_04070	COG0784	Response regulator, receiver
PI860_04075	COG0583	DNA-binding transcription factor activity
PI860_04080	COG2076	Multidrug Resistance protein
PI860_04090	COG0346	lactoylglutathione lyase activity
PI860_04095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PI860_04100	COG1643	Atp-dependent helicase
PI860_04110	COG1489	DNA binding
PI860_04115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PI860_04120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI860_04125	COG0617	tRNA 3'-terminal CCA addition
PI860_04130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PI860_04135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PI860_04140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PI860_04150	COG0842	Transport permease protein
PI860_04155	COG1131	(ABC) transporter
PI860_04170	COG0163	prenyltransferase activity
PI860_04175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PI860_04180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PI860_04185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PI860_04195	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PI860_04195	COG0506	proline dehydrogenase activity
PI860_04195	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PI860_04200	COG4991	sh3 domain protein
PI860_04205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PI860_04225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PI860_04230	COG1640	4-alpha-glucanotransferase
PI860_04235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PI860_04240	COG0676	glucose-6-phosphate 1-epimerase activity
PI860_04245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PI860_04315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PI860_04320	COG2885	chlorophyll binding
PI860_04325	COG0823	Involved in the tonB-independent uptake of proteins
PI860_04340	COG0811	peptide transport
PI860_04345	COG0824	Thioesterase
PI860_04350	COG3790	cyd operon protein YbgE
PI860_04355	COG4890	Cyd operon protein YbgT
PI860_04360	COG1294	oxidase, subunit
PI860_04365	COG1271	oxidase subunit
PI860_04370	COG2255	four-way junction helicase activity
PI860_04375	COG0632	four-way junction helicase activity
PI860_04380	COG0840	transmembrane signaling receptor activity
PI860_04385	COG0442	prolyl-tRNA aminoacylation
PI860_04395	COG1902	pentaerythritol trinitrate reductase activity
PI860_04405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PI860_04435	COG0714	Associated with various cellular activities
PI860_04445	COG0456	acetyltransferase
PI860_04455	COG1022	Amp-dependent synthetase and ligase
PI860_04465	COG2918	glutathione biosynthetic process
PI860_04470	COG0612	Peptidase, M16
PI860_04475	COG1238	metal cluster binding
PI860_04480	COG1064	alcohol dehydrogenase
PI860_04510	COG0359	binds to the 23S rRNA
PI860_04515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PI860_04520	COG0360	Binds together with S18 to 16S ribosomal RNA
PI860_04525	COG1914	H( )-stimulated, divalent metal cation uptake system
PI860_04545	COG2153	protein acetylation
PI860_04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PI860_04560	COG0557	exoribonuclease II activity
PI860_04565	COG3706	GGDEF domain
PI860_04570	COG1854	S-ribosylhomocysteine lyase activity
PI860_04585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PI860_04585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PI860_04625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PI860_04630	COG1047	Peptidyl-prolyl cis-trans
PI860_04635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PI860_04640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PI860_04645	COG0196	riboflavin kinase activity
PI860_04650	COG0728	peptidoglycan biosynthetic process
PI860_04655	COG0268	Binds directly to 16S ribosomal RNA
PI860_04660	COG0640	Transcriptional regulator
PI860_04665	COG0583	DNA-binding transcription factor activity
PI860_04675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PI860_04680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PI860_04685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PI860_04695	COG1051	belongs to the nudix hydrolase family
PI860_04700	COG3066	DNA modification
PI860_04710	COG0335	large ribosomal subunit rRNA binding
PI860_04715	COG0336	Belongs to the RNA methyltransferase TrmD family
PI860_04720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PI860_04725	COG0228	four-way junction DNA binding
PI860_04730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PI860_04735	COG4137	Cytochrome C assembly protein
PI860_04740	COG4536	flavin adenine dinucleotide binding
PI860_04745	COG1959	2 iron, 2 sulfur cluster binding
PI860_04750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI860_04750	COG1017	nitric oxide dioxygenase activity
PI860_04755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PI860_04760	COG0039	L-malate dehydrogenase activity
PI860_04765	COG4160	amino acid transport
PI860_04775	COG4215	(ABC) transporter
PI860_04780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_04785	COG1126	abc transporter atp-binding protein
PI860_04790	COG1438	arginine binding
PI860_04795	COG2837	iron assimilation
PI860_04800	COG3842	ATPase activity
PI860_04810	COG1840	ABC-type Fe3 transport system, periplasmic component
PI860_04815	COG0347	Belongs to the P(II) protein family
PI860_04830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PI860_04850	COG1929	Belongs to the glycerate kinase type-1 family
PI860_04855	COG2610	gluconate transmembrane transporter activity
PI860_04855	COG2610	gluconate transmembrane transporter activity
PI860_04860	COG3835	regulator
PI860_04865	COG3112	Uncharacterised protein family (UPF0231)
PI860_04880	COG0840	transmembrane signaling receptor activity
PI860_04885	COG3568	Endonuclease Exonuclease Phosphatase
PI860_04900	COG0513	Belongs to the DEAD box helicase family
PI860_04940	COG1448	Aminotransferase
PI860_04960	COG1328	CTP reductase activity
PI860_04995	COG1215	transferase activity, transferring glycosyl groups
PI860_05000	COG0726	polysaccharide deacetylase
PI860_05000	COG1649	PFAM Uncharacterised BCR, COG1649
PI860_05005	COG0726	polysaccharide deacetylase
PI860_05005	COG1649	PFAM Uncharacterised BCR, COG1649
PI860_05045	COG0840	transmembrane signaling receptor activity
PI860_05050	COG3397	chitin binding
PI860_05055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_05060	COG1126	abc transporter atp-binding protein
PI860_05070	COG0765	amino acid transport
PI860_05075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PI860_05080	COG0583	DNA-binding transcription factor activity
PI860_05085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PI860_05090	COG4208	sulfate ABC transporter
PI860_05095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PI860_05105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PI860_05110	COG3174	membrane
PI860_05115	COG0110	maltose O-acetyltransferase activity
PI860_05145	COG1942	4-Oxalocrotonate Tautomerase
PI860_05155	COG0583	DNA-binding transcription factor activity
PI860_05160	COG0165	Argininosuccinate lyase
PI860_05165	COG0137	argininosuccinate synthase activity
PI860_05175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PI860_05180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PI860_05190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PI860_05200	COG2072	flavoprotein involved in K transport
PI860_05205	COG1393	Belongs to the ArsC family
PI860_05210	COG0798	PFAM Bile acid sodium symporter
PI860_05230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PI860_05250	COG3068	Protein conserved in bacteria
PI860_05260	COG0739	heme binding
PI860_05280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PI860_05285	COG1121	(ABC) transporter
PI860_05290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PI860_05295	COG0583	DNA-binding transcription factor activity
PI860_05305	COG1573	uracil-dna glycosylase
PI860_05310	COG2962	Rard protein
PI860_05320	COG2827	Endonuclease containing a URI domain
PI860_05335	COG1842	Phage shock protein A
PI860_05340	COG0204	Acyl-transferase
PI860_05360	COG3118	belongs to the thioredoxin family
PI860_05365	COG2259	Doxx family
PI860_05420	COG1051	belongs to the nudix hydrolase family
PI860_05425	COG3150	esterase
PI860_05435	COG3151	Protein conserved in bacteria
PI860_05440	COG0494	nUDIX hydrolase
PI860_05450	COG1538	Outer membrane efflux protein
PI860_05455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PI860_05455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PI860_05460	COG1560	Kdo2-lipid A biosynthetic process
PI860_05475	COG1392	Phosphate transport regulator
PI860_05480	COG0306	phosphate transporter
PI860_05485	COG0617	tRNA 3'-terminal CCA addition
PI860_05490	COG3267	Type II secretory pathway component ExeA
PI860_05490	COG3409	Peptidoglycan-binding domain 1 protein
PI860_05500	COG1194	a g-specific adenine glycosylase
PI860_05505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PI860_05515	COG3111	PFAM Bacterial OB fold (BOF) protein
PI860_05520	COG3240	lipase activity
PI860_05535	COG3009	Protein conserved in bacteria
PI860_05540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PI860_05540	COG3008	intermembrane lipid transfer
PI860_05545	COG2995	paraquat-inducible protein a
PI860_05555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PI860_05570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI860_05575	COG2813	Specifically methylates the guanine in position
PI860_05580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PI860_05585	COG0297	glycogen (starch) synthase activity
PI860_05625	COG1757	Na H antiporter
PI860_05635	COG0110	maltose O-acetyltransferase activity
PI860_05640	COG0366	Alpha amylase catalytic
PI860_05660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PI860_05665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PI860_05670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PI860_05675	COG2723	6-phospho-beta-galactosidase activity
PI860_05680	COG1447	Phosphotransferase system cellobiose-specific component IIA
PI860_05685	COG1940	carbohydrate kinase activity
PI860_05695	COG1609	Transcriptional regulator
PI860_05705	COG0252	asparaginase activity
PI860_05720	COG1803	Methylglyoxal synthase
PI860_05745	COG1444	tRNA N-acetyltransferase activity
PI860_05750	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_05755	COG0784	Response regulator, receiver
PI860_05755	COG0835	chemotaxis
PI860_05765	COG3314	Sporulation integral membrane protein YlbJ
PI860_05865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PI860_05870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PI860_05885	COG0477	Major facilitator Superfamily
PI860_05890	COG0523	cobalamin synthesis protein
PI860_05900	COG1280	lysine exporter protein (LysE YggA)
PI860_05910	COG0583	DNA-binding transcription factor activity
PI860_05915	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_05920	COG2200	EAL domain
PI860_05925	COG1049	propionate catabolic process, 2-methylcitrate cycle
PI860_05940	COG0840	transmembrane signaling receptor activity
PI860_05950	COG3447	MASE1 domain protein
PI860_05950	COG5001	Diguanylate cyclase
PI860_05950	COG5002	protein histidine kinase activity
PI860_05955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PI860_05960	COG0508	dehydrogenase complex catalyzes the overall conversion of
PI860_05965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PI860_05970	COG2186	Transcriptional regulator
PI860_05995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PI860_06005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PI860_06015	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PI860_06020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PI860_06025	COG0494	nUDIX hydrolase
PI860_06035	COG0653	protein targeting
PI860_06045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PI860_06050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PI860_06055	COG0849	cell division
PI860_06060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PI860_06065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PI860_06070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PI860_06075	COG0772	Belongs to the SEDS family
PI860_06080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PI860_06085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PI860_06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PI860_06100	COG0768	penicillin binding
PI860_06105	COG3116	cell division
PI860_06110	COG0275	rRNA processing
PI860_06115	COG2001	Belongs to the MraZ family
PI860_06125	COG0741	lytic transglycosylase activity
PI860_06125	COG1388	LysM domain
PI860_06130	COG1360	Flagellar Motor Protein
PI860_06135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PI860_06165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PI860_06180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PI860_06210	COG1706	bacterial-type flagellum-dependent cell motility
PI860_06215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PI860_06220	COG4786	Flagellar basal body rod
PI860_06225	COG4786	Flagellar basal body rod
PI860_06230	COG1749	Flagellar hook protein flgE
PI860_06250	COG1815	bacterial-type flagellum-dependent cell motility
PI860_06260	COG2747	anti-sigma28 factor FlgM
PI860_06285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PI860_06295	COG1677	Flagellar hook-basal body complex protein FliE
PI860_06320	COG1987	bacterial-type flagellum assembly
PI860_06345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PI860_06350	COG3107	peptidoglycan biosynthetic process
PI860_06355	COG0792	nuclease activity
PI860_06360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PI860_06365	COG2823	Periplasmic or secreted lipoprotein
PI860_06370	COG2969	positive regulation of protein catabolic process
PI860_06375	COG0625	glutathione transferase activity
PI860_06380	COG2857	Cytochrome c1
PI860_06385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PI860_06390	COG0723	plastoquinol--plastocyanin reductase activity
PI860_06395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PI860_06400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PI860_06405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PI860_06415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI860_06420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI860_06450	COG3964	amidohydrolase
PI860_06470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_06475	COG1660	Displays ATPase and GTPase activities
PI860_06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_06490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PI860_06495	COG1137	ATPase activity
PI860_06500	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PI860_06505	COG3117	lipopolysaccharide transmembrane transporter activity
PI860_06510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PI860_06515	COG0517	IMP dehydrogenase activity
PI860_06515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PI860_06520	COG1127	ABC transporter
PI860_06525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PI860_06530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PI860_06535	COG2854	intermembrane phospholipid transfer
PI860_06545	COG5007	Belongs to the BolA IbaG family
PI860_06550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PI860_06555	COG0312	modulator of DNA gyrase
PI860_06560	COG3028	Belongs to the UPF0307 family
PI860_06570	COG2926	Belongs to the UPF0265 family
PI860_06595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PI860_06600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PI860_06605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PI860_06610	COG0049	tRNA binding
PI860_06615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PI860_06620	COG2168	tRNA wobble position uridine thiolation
PI860_06625	COG2923	Belongs to the DsrF TusC family
PI860_06640	COG2964	Protein conserved in bacteria
PI860_06645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PI860_06650	COG0085	RNA polymerase activity
PI860_06655	COG0222	ribosome binding
PI860_06660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PI860_06665	COG0081	regulation of translation
PI860_06670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PI860_06675	COG0250	Participates in transcription elongation, termination and antitermination
PI860_06690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PI860_06715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PI860_06720	COG0569	domain protein
PI860_06725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PI860_06730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PI860_06735	COG3005	denitrification pathway
PI860_06740	COG0243	molybdopterin cofactor binding
PI860_06770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PI860_06775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PI860_06785	COG2204	response regulator
PI860_06795	COG2205	protein histidine kinase activity
PI860_06810	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_06815	COG0517	IMP dehydrogenase activity
PI860_06815	COG0617	tRNA 3'-terminal CCA addition
PI860_06815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PI860_06830	COG1522	sequence-specific DNA binding
PI860_06835	COG2502	aspartate--ammonia ligase
PI860_06840	COG0542	response to heat
PI860_06850	COG0564	pseudouridine synthase activity
PI860_06855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PI860_06860	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI860_06870	COG3681	Belongs to the UPF0597 family
PI860_06875	COG2964	Protein conserved in bacteria
PI860_06885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PI860_06890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PI860_06895	COG1979	alcohol dehydrogenase
PI860_06900	COG2207	Transcriptional regulator
PI860_06905	COG3040	lipid binding
PI860_06915	COG0688	phosphatidylethanolamine metabolic process
PI860_06930	COG0540	Belongs to the ATCase OTCase family
PI860_06935	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PI860_06940	COG1438	arginine binding
PI860_06945	COG1288	antiporter activity
PI860_06950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PI860_07005	COG1609	Transcriptional regulator
PI860_07010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PI860_07020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PI860_07025	COG2017	converts alpha-aldose to the beta-anomer
PI860_07030	COG0667	Aldo Keto reductase
PI860_07035	COG1968	undecaprenyl-diphosphatase activity
PI860_07045	COG1595	DNA-templated transcription, initiation
PI860_07055	COG0018	arginyl-trna synthetase
PI860_07065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PI860_07070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PI860_07085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PI860_07100	COG2116	formate transmembrane transporter activity
PI860_07105	COG1648	precorrin-2 dehydrogenase activity
PI860_07105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PI860_07110	COG2239	Acts as a magnesium transporter
PI860_07125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI860_07130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PI860_07140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PI860_07150	COG0514	ATP-dependent DNA helicase (RecQ)
PI860_07155	COG2050	protein possibly involved in aromatic compounds catabolism
PI860_07170	COG2258	MOSC domain
PI860_07175	COG1177	transmembrane transport
PI860_07180	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI860_07185	COG3842	ATPase activity
PI860_07205	COG0174	glutamine synthetase
PI860_07220	COG3045	CreA protein
PI860_07225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PI860_07230	COG0443	Heat shock 70 kDa protein
PI860_07245	COG0366	Alpha amylase catalytic
PI860_07250	COG1086	Polysaccharide biosynthesis protein
PI860_07270	COG1442	glycosyl transferase family 8
PI860_07290	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_07310	COG1083	cytidylyl-transferase
PI860_07320	COG2089	acid synthase
PI860_07390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PI860_07395	COG0745	RESPONSE REGULATOR receiver
PI860_07400	COG2205	protein histidine kinase activity
PI860_07410	COG0281	malic enzyme
PI860_07415	COG0702	epimerase
PI860_07420	COG0254	rRNA binding
PI860_07425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PI860_07435	COG1309	transcriptional regulator
PI860_07455	COG0129	dihydroxy-acid dehydratase activity
PI860_07465	COG3978	acetolactate synthase activity
PI860_07480	COG0204	Acyl-transferase
PI860_07485	COG1683	Conserved Protein
PI860_07495	COG1335	isochorismatase
PI860_07505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PI860_07510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PI860_07515	COG3639	organic phosphonate transmembrane transporter activity
PI860_07520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PI860_07525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PI860_07535	COG3084	Protein conserved in bacteria
PI860_07540	COG2203	Gaf domain
PI860_07540	COG3706	GGDEF domain
PI860_07540	COG4251	negative regulation of phosphorylation
PI860_07540	COG5001	Diguanylate cyclase
PI860_07555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PI860_07565	COG1561	YicC-like family, N-terminal region
PI860_07595	COG0438	transferase activity, transferring glycosyl groups
PI860_07600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI860_07615	COG1063	alcohol dehydrogenase
PI860_07630	COG0210	DNA helicase
PI860_07635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PI860_07640	COG2166	iron-sulfur cluster assembly
PI860_07645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PI860_07675	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
PI860_07680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PI860_07685	COG1739	Uncharacterized protein family UPF0029
PI860_07690	COG0006	proline dipeptidase activity
PI860_07695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI860_07700	COG1024	Enoyl-CoA hydratase
PI860_07700	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI860_07705	COG0183	Belongs to the thiolase family
PI860_07735	COG0425	Belongs to the sulfur carrier protein TusA family
PI860_07740	COG0251	oxidation-reduction process
PI860_07745	COG2885	chlorophyll binding
PI860_07750	COG2818	Glycosylase
PI860_07755	COG0752	glycyl-tRNA synthetase alpha subunit
PI860_07760	COG0751	glycine-tRNA ligase activity
PI860_07770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PI860_07780	COG2199	diguanylate cyclase activity
PI860_07780	COG2200	EAL domain
PI860_07780	COG2202	Pas domain
PI860_07795	COG0814	amino acid
PI860_07800	COG0348	domain, Protein
PI860_07810	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI860_07815	COG1773	rubredoxin
PI860_07815	COG0426	domain, Protein
PI860_07820	COG3604	Transcriptional regulator
PI860_07825	COG2188	Transcriptional regulator
PI860_07840	COG1609	Transcriptional regulator
PI860_07880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PI860_07905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PI860_07920	COG3118	belongs to the thioredoxin family
PI860_07925	COG0513	Belongs to the DEAD box helicase family
PI860_07930	COG0248	Ppx GppA phosphatase
PI860_07940	COG0742	ribosomal rna small subunit methyltransferase
PI860_07945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_07965	COG0084	hydrolase, TatD family'
PI860_07970	COG0805	protein transport
PI860_07975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PI860_07985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PI860_07990	COG3165	ubiquinone biosynthetic process from chorismate
PI860_08000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PI860_08045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PI860_08050	COG0848	biopolymer transport protein
PI860_08055	COG0811	peptide transport
PI860_08060	COG0811	peptide transport
PI860_08070	COG2771	luxR family
PI860_08085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PI860_08100	COG1484	DNA-dependent DNA replication
PI860_08105	COG4584	PFAM Integrase catalytic
PI860_08110	COG0732	type I restriction modification DNA specificity domain
PI860_08165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PI860_08170	COG1349	DNA-binding transcription factor activity
PI860_08175	COG0745	RESPONSE REGULATOR receiver
PI860_08180	COG2205	protein histidine kinase activity
PI860_08190	COG4452	Inner membrane protein CreD
PI860_08195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PI860_08200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PI860_08205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PI860_08210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PI860_08215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PI860_08220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PI860_08225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PI860_08235	COG0356	it plays a direct role in the translocation of protons across the membrane
PI860_08240	COG3312	ion transport
PI860_08245	COG1475	DNA binding
PI860_08250	COG1192	Involved in chromosome partitioning
PI860_08255	COG0357	Ribosomal RNA small subunit methyltransferase G
PI860_08260	COG0445	tRNA wobble uridine modification
PI860_08265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PI860_08270	COG4774	siderophore transport
PI860_08275	COG4615	Cyclic peptide transporter
PI860_08280	COG1120	ATPase activity
PI860_08285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PI860_08295	COG4774	siderophore transport
PI860_08300	COG4607	ABC-type enterochelin transport system periplasmic component
PI860_08305	COG4604	ABC transporter, ATP-binding protein
PI860_08310	COG4605	iron ion homeostasis
PI860_08315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI860_08320	COG1132	(ABC) transporter
PI860_08325	COG1132	(ABC) transporter
PI860_08325	COG2375	cellular response to nickel ion
PI860_08335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PI860_08350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PI860_08365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PI860_08370	COG0706	membrane insertase activity
PI860_08375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PI860_08380	COG0594	ribonuclease P activity
PI860_08385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PI860_08390	COG1126	abc transporter atp-binding protein
PI860_08405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PI860_08410	COG0592	DNA-directed DNA polymerase activity
PI860_08435	COG2378	regulation of single-species biofilm formation
PI860_08440	COG0071	Belongs to the small heat shock protein (HSP20) family
PI860_08445	COG0071	Belongs to the small heat shock protein (HSP20) family
PI860_08470	COG3977	Valine--pyruvate aminotransferase
PI860_08495	COG0745	RESPONSE REGULATOR receiver
PI860_08500	COG2205	protein histidine kinase activity
PI860_08520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PI860_08525	COG4191	Histidine kinase
PI860_08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_08530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI860_08535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_08540	COG1309	transcriptional regulator
PI860_08570	COG0561	phosphatase activity
PI860_08575	COG2267	carboxylic ester hydrolase activity
PI860_08580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PI860_08585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PI860_08590	COG1758	RNA polymerase activity
PI860_08595	COG0194	GDP metabolic process
PI860_08600	COG0859	PFAM glycosyl transferase family 9
PI860_08605	COG3642	lipopolysaccharide core region biosynthetic process
PI860_08645	COG0589	response to stress
PI860_08650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PI860_08655	COG3706	GGDEF domain
PI860_08665	COG1528	Iron-storage protein
PI860_08670	COG2081	HI0933 family
PI860_08705	COG3188	usher protein
PI860_08725	COG4584	PFAM Integrase catalytic
PI860_08730	COG1484	DNA-dependent DNA replication
PI860_08745	COG2197	response regulator
PI860_08750	COG2205	protein histidine kinase activity
PI860_08750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_08760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_08760	COG2205	protein histidine kinase activity
PI860_08770	COG3275	phosphorelay sensor kinase activity
PI860_08775	COG3279	Response regulator of the LytR AlgR family
PI860_08780	COG2223	nitrite transmembrane transporter activity
PI860_08785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PI860_08790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PI860_08805	COG0583	DNA-binding transcription factor activity
PI860_08810	COG4206	TonB-dependent receptor
PI860_08815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PI860_08860	COG0583	DNA-binding transcription factor activity
PI860_08865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PI860_08870	COG0166	Belongs to the GPI family
PI860_08880	COG0668	transmembrane transport
PI860_08885	COG1309	transcriptional regulator
PI860_08890	COG0756	dUTP diphosphatase activity
PI860_08895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PI860_08900	COG2003	Belongs to the UPF0758 family
PI860_08905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PI860_08910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PI860_08920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PI860_08925	COG2990	Protein conserved in bacteria
PI860_08930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PI860_08935	COG0859	PFAM glycosyl transferase family 9
PI860_08940	COG0463	Glycosyl transferase, family 2
PI860_08945	COG0859	PFAM glycosyl transferase family 9
PI860_08950	COG1519	Transferase
PI860_08965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_08970	COG1609	Transcriptional regulator
PI860_08995	COG1580	Controls the rotational direction of flagella during chemotaxis
PI860_09000	COG3161	chorismate lyase activity
PI860_09005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PI860_09010	COG2937	Belongs to the GPAT DAPAT family
PI860_09015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PI860_09035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PI860_09040	COG2205	protein histidine kinase activity
PI860_09045	COG0745	RESPONSE REGULATOR receiver
PI860_09055	COG1045	serine acetyltransferase
PI860_09065	COG3074	FtsZ-dependent cytokinesis
PI860_09070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PI860_09080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PI860_09130	COG0385	Bile acid
PI860_09135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PI860_09155	COG0583	DNA-binding transcription factor activity
PI860_09160	COG1079	Belongs to the binding-protein-dependent transport system permease family
PI860_09165	COG4603	Belongs to the binding-protein-dependent transport system permease family
PI860_09170	COG3845	ABC transporter
PI860_09180	COG1744	ABC transporter substrate-binding protein PnrA-like
PI860_09185	COG0210	DNA helicase
PI860_09225	COG2823	Periplasmic or secreted lipoprotein
PI860_09245	COG0583	DNA-binding transcription factor activity
PI860_09250	COG1280	lysine exporter protein (LysE YggA)
PI860_09255	COG2391	methyltransferase activity
PI860_09265	COG1280	lysine exporter protein (LysE YggA)
PI860_09275	COG2962	Rard protein
PI860_09285	COG1012	belongs to the aldehyde dehydrogenase family
PI860_09295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PI860_09305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PI860_09305	COG0519	Catalyzes the synthesis of GMP from XMP
PI860_09310	COG0686	Belongs to the AlaDH PNT family
PI860_09315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PI860_09340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PI860_09345	COG0569	domain protein
PI860_09350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PI860_09350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI860_09355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PI860_09360	COG0242	peptide deformylase activity
PI860_09365	COG1652	LysM domain
PI860_09370	COG0758	DNA mediated transformation
PI860_09375	COG2922	Belongs to the Smg family
PI860_09380	COG0551	DNA topoisomerase type I activity
PI860_09390	COG0009	L-threonylcarbamoyladenylate synthase
PI860_09395	COG0408	coproporphyrinogen oxidase activity
PI860_09400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PI860_09410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PI860_09420	COG3078	GTPase activator activity
PI860_09430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PI860_09435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PI860_09440	COG2204	response regulator
PI860_09445	COG3852	Histidine kinase
PI860_09455	COG0174	glutamine synthetase
PI860_09460	COG1217	gtp-binding protein TYPA
PI860_09465	COG1295	ribonuclease BN
PI860_09480	COG0456	acetyltransferase
PI860_09490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PI860_09495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PI860_09500	COG2610	gluconate transmembrane transporter activity
PI860_09505	COG3265	gluconokinase activity
PI860_09510	COG0129	dihydroxy-acid dehydratase activity
PI860_09515	COG0800	Aldolase
PI860_09520	COG1609	Transcriptional regulator
PI860_09530	COG4942	peptidase
PI860_09535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PI860_09540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PI860_09545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PI860_09550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PI860_09555	COG0316	Belongs to the HesB IscA family
PI860_09555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PI860_09560	COG1040	competence protein
PI860_09565	COG0596	Alpha beta hydrolase
PI860_09585	COG2183	response to ionizing radiation
PI860_09590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PI860_09610	COG0051	transcription antitermination factor activity, RNA binding
PI860_09615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PI860_09620	COG0088	Forms part of the polypeptide exit tunnel
PI860_09625	COG0089	rRNA binding
PI860_09630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PI860_09635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PI860_09640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PI860_09645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PI860_09650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PI860_09655	COG0255	Belongs to the universal ribosomal protein uL29 family
PI860_09660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PI860_09665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PI860_09670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PI860_09675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PI860_09680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PI860_09685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PI860_09690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PI860_09695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PI860_09700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PI860_09705	COG1841	ribosomal large subunit assembly
PI860_09710	COG0200	Binds to the 23S rRNA
PI860_09715	COG0201	protein transport
PI860_09720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PI860_09725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PI860_09730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PI860_09735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PI860_09740	COG0202	RNA polymerase activity
PI860_09745	COG0203	ribosomal protein L17
PI860_09795	COG1484	DNA-dependent DNA replication
PI860_09800	COG4584	PFAM Integrase catalytic
PI860_09810	COG2376	Dihydroxyacetone kinase
PI860_09815	COG1461	Dihydroxyacetone kinase
PI860_09820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PI860_09820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_09820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
PI860_09830	COG3284	Transcriptional regulator
PI860_09835	COG0628	permease
PI860_09840	COG0494	nUDIX hydrolase
PI860_09865	COG0753	catalase activity
PI860_09890	COG2203	Gaf domain
PI860_09890	COG2199	diguanylate cyclase activity
PI860_09900	COG3842	ATPase activity
PI860_09910	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI860_09945	COG1741	Belongs to the pirin family
PI860_09950	COG2259	Doxx family
PI860_09955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PI860_09960	COG1074	ATP-dependent DNA helicase activity
PI860_09965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PI860_09975	COG0346	lactoylglutathione lyase activity
PI860_09990	COG0004	ammonium transporteR
PI860_09995	COG0347	Belongs to the P(II) protein family
PI860_10010	COG0840	transmembrane signaling receptor activity
PI860_10040	COG3706	GGDEF domain
PI860_10045	COG4771	TonB-dependent receptor
PI860_10050	COG1278	Cold shock
PI860_10055	COG2199	diguanylate cyclase activity
PI860_10060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PI860_10065	COG2197	response regulator
PI860_10085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PI860_10120	COG2249	NAD(P)H dehydrogenase (quinone) activity
PI860_10135	COG1770	oligopeptidase
PI860_10155	COG3714	YhhN family
PI860_10180	COG1301	dicarboxylic acid transport
PI860_10190	COG2095	MarC family integral membrane protein
PI860_10200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PI860_10210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PI860_10220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PI860_10245	COG0742	ribosomal rna small subunit methyltransferase
PI860_10250	COG0552	protein localization to endoplasmic reticulum
PI860_10255	COG2884	Cell division ATP-binding protein ftsE
PI860_10260	COG2177	Part of the ABC transporter FtsEX involved in
PI860_10270	COG0288	reversible hydration of carbon dioxide
PI860_10275	COG2188	Transcriptional regulator
PI860_10280	COG1228	amidohydrolase
PI860_10285	COG0010	Belongs to the arginase family
PI860_10290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PI860_10295	COG2986	histidine ammonia-lyase
PI860_10300	COG0387	Pfam Sodium calcium exchanger
PI860_10305	COG2264	protein methyltransferase activity
PI860_10310	COG2199	diguanylate cyclase activity
PI860_10310	COG2200	EAL domain
PI860_10370	COG1077	Cell shape determining protein MreB Mrl
PI860_10375	COG1792	Involved in formation and maintenance of cell shape
PI860_10380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PI860_10385	COG0424	maF-like protein
PI860_10390	COG1530	ribonuclease E activity
PI860_10395	COG3164	Protein of unknown function
PI860_10405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PI860_10410	COG0312	modulator of DNA gyrase
PI860_10435	COG3437	response regulator, receiver
PI860_10440	COG0784	Response regulator, receiver
PI860_10440	COG2205	protein histidine kinase activity
PI860_10440	COG5002	protein histidine kinase activity
PI860_10445	COG2172	sigma factor antagonist activity
PI860_10450	COG1366	Belongs to the anti-sigma-factor antagonist family
PI860_10460	COG3700	Belongs to the class B bacterial acid phosphatase family
PI860_10470	COG1639	'signal transduction protein
PI860_10495	COG0189	ligase activity
PI860_10500	COG0642	Histidine kinase
PI860_10505	COG0745	RESPONSE REGULATOR receiver
PI860_10525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PI860_10530	COG0352	thiamine-phosphate diphosphorylase activity
PI860_10535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PI860_10545	COG2022	thiamine diphosphate biosynthetic process
PI860_10570	COG0110	maltose O-acetyltransferase activity
PI860_10575	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
PI860_10590	COG0814	amino acid
PI860_10595	COG3932	Exopolysaccharide synthesis, ExoD
PI860_10610	COG1733	regulation of RNA biosynthetic process
PI860_10650	COG1494	fructose-1,6-bisphosphatase
PI860_10665	COG2959	enzyme of heme biosynthesis
PI860_10675	COG0181	hydroxymethylbilane synthase activity
PI860_10680	COG3072	Adenylate cyclase
PI860_10700	COG1965	Belongs to the frataxin family
PI860_10710	COG0019	diaminopimelate decarboxylase activity
PI860_10715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PI860_10730	COG1011	Hydrolase
PI860_10740	COG0668	transmembrane transport
PI860_10750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PI860_10755	COG0561	phosphatase activity
PI860_10770	COG0842	Transport permease protein
PI860_10770	COG1129	ABC transporter
PI860_10780	COG1058	Belongs to the CinA family
PI860_10780	COG1546	Belongs to the CinA family
PI860_10785	COG1418	mRNA catabolic process
PI860_10790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PI860_10800	COG1522	sequence-specific DNA binding
PI860_10805	COG1368	sulfuric ester hydrolase activity
PI860_10825	COG1285	pathogenesis
PI860_10845	COG4221	oxidoreductase activity
PI860_10875	COG2873	o-acetylhomoserine
PI860_10885	COG4533	DNA binding
PI860_10890	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PI860_10905	COG5380	lipid catabolic process
PI860_10910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PI860_10920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PI860_10925	COG2949	membrane
PI860_10930	COG3291	Pkd domain containing protein
PI860_10940	COG3539	Fimbrial protein
PI860_10950	COG3188	usher protein
PI860_10955	COG3121	Chaperone
PI860_10960	COG3539	Fimbrial protein
PI860_10980	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_10990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PI860_10995	COG0596	Alpha beta hydrolase
PI860_11000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PI860_11005	COG1169	isochorismate synthase
PI860_11010	COG1575	Belongs to the MenA family. Type 1 subfamily
PI860_11040	COG0513	Belongs to the DEAD box helicase family
PI860_11045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PI860_11050	COG1988	membrane-bound metal-dependent
PI860_11065	COG1671	Belongs to the UPF0178 family
PI860_11085	COG0484	heat shock protein binding
PI860_11090	COG3263	regulation of cellular component size
PI860_11095	COG3722	fumarate hydratase activity
PI860_11100	COG0246	Mannitol dehydrogenase
PI860_11105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_11105	COG2213	PTS system mannitol-specific
PI860_11120	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
PI860_11135	COG2771	luxR family
PI860_11150	COG3133	Outer membrane lipoprotein
PI860_11155	COG0456	acetyltransferase
PI860_11175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PI860_11180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PI860_11200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PI860_11205	COG1459	type II secretion system
PI860_11210	COG2165	general secretion pathway protein
PI860_11220	COG2165	general secretion pathway protein
PI860_11225	COG4795	General secretion pathway protein
PI860_11230	COG3156	type II secretion system protein K
PI860_11240	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PI860_11255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PI860_11260	COG1011	Hydrolase
PI860_11265	COG0494	nUDIX hydrolase
PI860_11270	COG1218	3'(2'),5'-bisphosphate nucleotidase
PI860_11275	COG0814	amino acid
PI860_11280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI860_11295	COG0626	cystathionine gamma-synthase activity
PI860_11300	COG0460	homoserine dehydrogenase
PI860_11300	COG0527	aspartate kinase activity
PI860_11315	COG1346	cytolysis
PI860_11320	COG1380	Effector of murein hydrolase LrgA
PI860_11355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PI860_11360	COG1546	Belongs to the CinA family
PI860_11365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PI860_11375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PI860_11380	COG0527	aspartate kinase activity
PI860_11385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PI860_11410	COG1686	Belongs to the peptidase S11 family
PI860_11415	COG0586	Pfam SNARE associated Golgi protein
PI860_11420	COG1253	flavin adenine dinucleotide binding
PI860_11430	COG2927	DNA polymerase III (CHI subunit)
PI860_11435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PI860_11440	COG0795	lipopolysaccharide-transporting ATPase activity
PI860_11445	COG0795	lipopolysaccharide-transporting ATPase activity
PI860_11590	COG4695	Portal protein
PI860_11675	COG2932	Transcriptional regulator
PI860_11680	COG4974	Belongs to the 'phage' integrase family
PI860_11685	COG0582	viral genome integration into host DNA
PI860_11705	COG3561	AntA/AntB antirepressor
PI860_11755	COG0004	ammonium transporteR
PI860_11760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PI860_11775	COG2165	general secretion pathway protein
PI860_11780	COG0084	hydrolase, TatD family'
PI860_11785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PI860_11795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PI860_11800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PI860_11805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PI860_11810	COG0813	purine-nucleoside phosphorylase activity
PI860_11820	COG0560	Phosphoserine phosphatase
PI860_11845	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PI860_11850	COG0776	regulation of translation
PI860_11865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PI860_11870	COG0735	belongs to the Fur family
PI860_11890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PI860_11895	COG0513	Belongs to the DEAD box helicase family
PI860_11900	COG3022	response to hydroperoxide
PI860_11915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PI860_11920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PI860_11925	COG0762	integral membrane protein
PI860_11930	COG1872	DUF167
PI860_11945	COG4166	transmembrane transport
PI860_11955	COG0110	maltose O-acetyltransferase activity
PI860_11965	COG1024	Enoyl-CoA hydratase
PI860_11980	COG4221	oxidoreductase activity
PI860_11990	COG2957	Belongs to the agmatine deiminase family
PI860_12015	COG0513	Belongs to the DEAD box helicase family
PI860_12035	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
PI860_12100	COG2816	NAD+ diphosphatase activity
PI860_12105	COG2205	protein histidine kinase activity
PI860_12110	COG0745	RESPONSE REGULATOR receiver
PI860_12115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_12120	COG0577	efflux transmembrane transporter activity
PI860_12120	COG1136	(ABC) transporter
PI860_12125	COG1505	serine-type exopeptidase activity
PI860_12130	COG2982	Protein involved in outer membrane biogenesis
PI860_12150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PI860_12155	COG3730	PTS system glucitol sorbitol-specific
PI860_12170	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_12180	COG1349	DNA-binding transcription factor activity
PI860_12185	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PI860_12200	COG0494	nUDIX hydrolase
PI860_12205	COG2130	NADP-dependent
PI860_12210	COG1764	response to oxidative stress
PI860_12215	COG1846	Transcriptional regulator
PI860_12245	COG0561	phosphatase activity
PI860_12260	COG0733	neurotransmitter:sodium symporter activity
PI860_12270	COG0733	neurotransmitter:sodium symporter activity
PI860_12310	COG1794	racemase activity, acting on amino acids and derivatives
PI860_12320	COG2731	YhcH YjgK YiaL family protein
PI860_12330	COG0668	transmembrane transport
PI860_12335	COG1376	ErfK ybiS ycfS ynhG family protein
PI860_12340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI860_12350	COG0789	Transcriptional regulator
PI860_12415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PI860_12425	COG0488	(ABC) transporter
PI860_12430	COG0517	IMP dehydrogenase activity
PI860_12430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PI860_12435	COG1585	Membrane protein implicated in regulation of membrane protease activity
PI860_12440	COG0330	HflC and HflK could
PI860_12445	COG1648	precorrin-2 dehydrogenase activity
PI860_12445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PI860_12450	COG0175	sulfate reduction
PI860_12455	COG2895	sulfate adenylyltransferase (ATP) activity
PI860_12460	COG3273	potassium ion transport
PI860_12460	COG0471	metal ion transport
PI860_12465	COG0529	Catalyzes the synthesis of activated sulfate
PI860_12480	COG0840	transmembrane signaling receptor activity
PI860_12500	COG1136	(ABC) transporter
PI860_12515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
PI860_12530	COG1940	carbohydrate kinase activity
PI860_12535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PI860_12540	COG0126	phosphoglycerate kinase activity
PI860_12545	COG0191	fructose-bisphosphate aldolase activity
PI860_12550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI860_12600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PI860_12605	COG1595	DNA-templated transcription, initiation
PI860_12610	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
PI860_12625	COG0481	GTPase activity
PI860_12635	COG0571	ribonuclease III activity
PI860_12645	COG1381	Involved in DNA repair and RecF pathway recombination
PI860_12650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PI860_12655	COG3023	N-Acetylmuramoyl-L-alanine amidase
PI860_12660	COG4807	Protein conserved in bacteria
PI860_12670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PI860_12675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PI860_12680	COG3956	TIGRFAM MazG family protein
PI860_12685	COG0504	CTP synthase activity
PI860_12690	COG0148	phosphopyruvate hydratase activity
PI860_12695	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PI860_12700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PI860_12710	COG0585	pseudouridine synthase activity
PI860_12715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PI860_12720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PI860_12725	COG1238	metal cluster binding
PI860_12730	COG1388	LysM domain
PI860_12730	COG4942	peptidase
PI860_12740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PI860_12745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PI860_12750	COG1610	YqeY-like protein
PI860_12755	COG0358	DNA primase activity
PI860_12760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PI860_12800	COG0151	Belongs to the GarS family
PI860_12805	COG0138	bifunctional purine biosynthesis protein purh
PI860_12815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PI860_12820	COG3036	rescue of stalled ribosome
PI860_12825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PI860_12830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PI860_12855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PI860_12860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PI860_12875	COG0477	Major facilitator Superfamily
PI860_12885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PI860_12890	COG1027	Aspartate ammonia-lyase
PI860_12895	COG3030	protein affecting phage T7 exclusion by the F plasmid
PI860_12900	COG0534	Mate efflux family protein
PI860_12905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PI860_12910	COG0459	protein refolding
PI860_12920	COG3300	MHYT domain
PI860_12920	COG5001	Diguanylate cyclase
PI860_12930	COG0564	pseudouridine synthase activity
PI860_12935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PI860_12965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PI860_12975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PI860_12980	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
PI860_12985	COG1178	ABC-type Fe3 transport system permease component
PI860_12990	COG4143	(ABC) transporter
PI860_13005	COG0066	3-isopropylmalate dehydratase activity
PI860_13010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PI860_13015	COG0473	3-isopropylmalate dehydrogenase activity
PI860_13020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PI860_13030	COG0671	phosphoesterase, PA-phosphatase related
PI860_13045	COG0028	Belongs to the TPP enzyme family
PI860_13050	COG0440	acetolactate synthase activity
PI860_13055	COG0280	phosphate acetyltransferase
PI860_13055	COG0857	belongs to the CobB CobQ family
PI860_13060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PI860_13070	COG3013	Belongs to the UPF0304 family
PI860_13075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PI860_13080	COG2716	regulation of RNA biosynthetic process
PI860_13090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PI860_13095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PI860_13130	COG2198	Histidine kinase
PI860_13130	COG5002	protein histidine kinase activity
PI860_13130	COG0784	Response regulator, receiver
PI860_13145	COG2205	protein histidine kinase activity
PI860_13145	COG3437	response regulator, receiver
PI860_13145	COG3850	Histidine kinase
PI860_13145	COG4999	Histidine kinase
PI860_13160	COG0840	transmembrane signaling receptor activity
PI860_13170	COG1464	Belongs to the NlpA lipoprotein family
PI860_13175	COG2011	ABC-type metal ion transport system permease component
PI860_13200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PI860_13200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PI860_13205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PI860_13205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PI860_13210	COG0802	atpase or kinase
PI860_13225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PI860_13230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PI860_13235	COG1923	regulation of RNA biosynthetic process
PI860_13240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PI860_13245	COG0330	HflC and HflK could
PI860_13250	COG0330	HflC and HflK could
PI860_13255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
PI860_13260	COG0142	geranyltranstransferase activity
PI860_13265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PI860_13270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PI860_13275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PI860_13280	COG3314	Sporulation integral membrane protein YlbJ
PI860_13285	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_13295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PI860_13305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PI860_13320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PI860_13325	COG2967	ApaG domain
PI860_13330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PI860_13335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PI860_13345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PI860_13350	COG3178	'Phosphotransferase
PI860_13355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PI860_13360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PI860_13375	COG0488	(ABC) transporter
PI860_13400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI860_13410	COG3721	Heme iron utilization protein
PI860_13415	COG0748	coenzyme F420 binding
PI860_13435	COG4771	TonB-dependent receptor
PI860_13440	COG2814	Major facilitator Superfamily
PI860_13450	COG3655	Transcriptional regulator
PI860_13475	COG3397	chitin binding
PI860_13490	COG1765	OsmC-like protein
PI860_13505	COG3954	Phosphoribulokinase
PI860_13510	COG2076	Multidrug Resistance protein
PI860_13515	COG2076	Multidrug Resistance protein
PI860_13520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PI860_13525	COG0726	polysaccharide deacetylase
PI860_13535	COG0463	Glycosyl transferase, family 2
PI860_13540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PI860_13550	COG3089	Belongs to the UPF0270 family
PI860_13555	COG5001	Diguanylate cyclase
PI860_13555	COG2203	Gaf domain
PI860_13555	COG3706	GGDEF domain
PI860_13555	COG4251	negative regulation of phosphorylation
PI860_13560	COG0429	hydrolase of the alpha beta-hydrolase fold
PI860_13565	COG0835	chemotaxis
PI860_13565	COG0784	Response regulator, receiver
PI860_13575	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PI860_13580	COG1047	Peptidyl-prolyl cis-trans
PI860_13595	COG0545	Peptidyl-prolyl cis-trans isomerase
PI860_13600	COG2204	response regulator
PI860_13620	COG0737	Belongs to the 5'-nucleotidase family
PI860_13625	COG2200	EAL domain
PI860_13645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PI860_13650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PI860_13655	COG0826	peptidase U32
PI860_13660	COG2199	diguanylate cyclase activity
PI860_13660	COG2200	EAL domain
PI860_13660	COG2203	Gaf domain
PI860_13690	COG2197	response regulator
PI860_13695	COG2197	response regulator
PI860_13725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PI860_13730	COG2201	protein-glutamate methylesterase activity
PI860_13735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PI860_13745	COG0840	transmembrane signaling receptor activity
PI860_13750	COG0835	chemotaxis
PI860_13760	COG0643	Histidine kinase
PI860_13760	COG2198	Histidine kinase
PI860_13770	COG0745	RESPONSE REGULATOR receiver
PI860_13780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PI860_13790	COG1280	lysine exporter protein (LysE YggA)
PI860_13805	COG3813	Protein conserved in bacteria
PI860_13820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PI860_13835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PI860_13860	COG0300	oxidoreductase activity
PI860_13880	COG2133	pyrroloquinoline quinone binding
PI860_13905	COG1605	Chorismate mutase
PI860_13905	COG0077	Prephenate dehydratase
PI860_13935	COG3272	Protein of unknown function (DUF1722)
PI860_13940	COG0789	Transcriptional regulator
PI860_13945	COG0415	Belongs to the DNA photolyase family
PI860_13955	COG0300	oxidoreductase activity
PI860_13970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PI860_13995	COG0783	Belongs to the Dps family
PI860_14000	COG1151	hydroxylamine reductase activity
PI860_14010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PI860_14015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PI860_14015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PI860_14025	COG3459	Glycosyltransferase 36 associated
PI860_14050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PI860_14055	COG1666	GTP binding
PI860_14060	COG3248	Nucleoside-binding outer membrane protein
PI860_14065	COG2211	Major facilitator Superfamily
PI860_14075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PI860_14085	COG2813	Specifically methylates the guanine in position
PI860_14090	COG0271	Belongs to the BolA IbaG family
PI860_14100	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PI860_14105	COG1805	sodium ion transport
PI860_14110	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PI860_14115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PI860_14120	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PI860_14125	COG2871	sodium ion transport
PI860_14130	COG1477	protein flavinylation
PI860_14145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PI860_14150	COG0840	transmembrane signaling receptor activity
PI860_14155	COG0583	DNA-binding transcription factor activity
PI860_14165	COG2363	Small membrane protein
PI860_14170	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PI860_14180	COG0473	3-isopropylmalate dehydrogenase activity
PI860_14185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PI860_14190	COG1611	Belongs to the LOG family
PI860_14205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PI860_14205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PI860_14215	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PI860_14240	COG3098	single-species biofilm formation
PI860_14245	COG0564	pseudouridine synthase activity
PI860_14255	COG4580	involved in the transport of maltose and maltodextrins
PI860_14275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PI860_14275	COG1263	PTS System
PI860_14285	COG2171	N-acyltransferase activity
PI860_14295	COG0024	Methionine aminopeptidase
PI860_14300	COG0052	Belongs to the universal ribosomal protein uS2 family
PI860_14305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PI860_14310	COG0528	UMP kinase activity
PI860_14315	COG0233	cytoplasmic translational termination
PI860_14320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PI860_14325	COG0575	Belongs to the CDS family
PI860_14330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PI860_14335	COG0750	zinc metalloprotease
PI860_14350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI860_14355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PI860_14360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI860_14365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI860_14370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PI860_14380	COG0825	malonyl-CoA metabolic process
PI860_14385	COG3710	Transcriptional regulator
PI860_14390	COG0531	amino acid
PI860_14395	COG1982	Orn Lys Arg decarboxylase major
PI860_14400	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PI860_14415	COG0814	amino acid
PI860_14420	COG0531	amino acid
PI860_14430	COG0488	(ABC) transporter
PI860_14440	COG3590	peptidase
PI860_14445	COG0037	tRNA processing
PI860_14495	COG0366	Alpha amylase catalytic
PI860_14505	COG1881	PFAM PEBP family protein
PI860_14510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PI860_14515	COG0583	DNA-binding transcription factor activity
PI860_14525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PI860_14535	COG0583	DNA-binding transcription factor activity
PI860_14540	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_14545	COG0616	signal peptide processing
PI860_14550	COG3724	N-succinylarginine dihydrolase activity
PI860_14570	COG0840	transmembrane signaling receptor activity
PI860_14580	COG2971	BadF BadG BcrA BcrD
PI860_14590	COG4608	Belongs to the ABC transporter superfamily
PI860_14595	COG0444	Belongs to the ABC transporter superfamily
PI860_14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI860_14605	COG0601	transmembrane transport
PI860_14615	COG0784	Response regulator, receiver
PI860_14615	COG2205	protein histidine kinase activity
PI860_14650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PI860_14655	COG1289	transmembrane transporter activity
PI860_14660	COG0303	'Molybdopterin
PI860_14665	COG0746	molybdenum cofactor guanylyltransferase activity
PI860_14675	COG4662	Binding-protein-dependent transport system inner membrane component
PI860_14690	COG3852	Histidine kinase
PI860_14700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PI860_14705	COG2801	Transposase and inactivated derivatives
PI860_14735	COG1196	nuclear chromosome segregation
PI860_14735	COG3264	Mechanosensitive ion channel
PI860_14740	COG0469	pyruvate kinase activity
PI860_14760	COG0405	Gamma-glutamyltransferase
PI860_14765	COG2974	May be involved in recombination
PI860_14775	COG0420	3'-5' exonuclease activity
PI860_14780	COG0419	ATPase involved in DNA repair
PI860_14790	COG3038	cytochrome b561
PI860_14805	COG2190	(PTS) system
PI860_14815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_14820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PI860_14840	COG1720	tRNA m6t6A37 methyltransferase activity
PI860_14860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PI860_14865	COG4988	ABC transporter
PI860_14880	COG0745	RESPONSE REGULATOR receiver
PI860_14890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI860_14905	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PI860_14910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PI860_14920	COG0083	homoserine kinase activity
PI860_14925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PI860_14955	COG1943	Transposase
PI860_14975	COG0813	purine-nucleoside phosphorylase activity
PI860_14990	COG3384	dioxygenase
PI860_15000	COG1283	sodium-dependent phosphate transmembrane transporter activity
PI860_15005	COG0531	amino acid
PI860_15010	COG0531	amino acid
PI860_15025	COG1396	sequence-specific DNA binding
PI860_15025	COG1917	Cupin 2, conserved barrel domain protein
PI860_15030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI860_15040	COG1917	Cupin 2, conserved barrel domain protein
PI860_15040	COG2169	Transcriptional regulator
PI860_15065	COG2916	Histone family protein nucleoid-structuring protein H-NS
PI860_15070	COG3328	transposase activity
PI860_15075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PI860_15080	COG2375	cellular response to nickel ion
PI860_15085	COG1538	Outer membrane efflux protein
PI860_15090	COG0577	efflux transmembrane transporter activity
PI860_15090	COG1136	(ABC) transporter
PI860_15095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_15105	COG1227	inorganic diphosphatase activity
PI860_15110	COG0497	DNA recombination
PI860_15115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PI860_15120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PI860_15125	COG0443	Heat shock 70 kDa protein
PI860_15130	COG0484	heat shock protein binding
PI860_15160	COG1285	pathogenesis
PI860_15205	COG0095	Lipoate-protein ligase
PI860_15215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI860_15220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI860_15245	COG0708	Exodeoxyribonuclease III
PI860_15300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PI860_15305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PI860_15310	COG1845	cytochrome c oxidase, subunit III
PI860_15315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PI860_15320	COG0109	protoheme IX farnesyltransferase activity
PI860_15325	COG2814	Major facilitator Superfamily
PI860_15345	COG1609	Transcriptional regulator
PI860_15350	COG1263	PTS System
PI860_15350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PI860_15355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PI860_15385	COG2207	Transcriptional regulator
PI860_15390	COG0538	isocitrate dehydrogenase activity
PI860_15400	COG3048	D-serine ammonia-lyase activity
PI860_15405	COG2610	gluconate transmembrane transporter activity
PI860_15410	COG0583	DNA-binding transcription factor activity
PI860_15485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PI860_15490	COG2867	negative regulation of translational initiation
PI860_15495	COG2914	Belongs to the UPF0125 (RnfH) family
PI860_15500	COG0702	epimerase
PI860_15505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PI860_15540	COG4964	Belongs to the GSP D family
PI860_15550	COG2894	cell division
PI860_15590	COG1454	alcohol dehydrogenase
PI860_15605	COG1957	nucleoside hydrolase
PI860_15625	COG0840	transmembrane signaling receptor activity
PI860_15630	COG1280	lysine exporter protein (LysE YggA)
PI860_15650	COG3263	regulation of cellular component size
PI860_15660	COG1876	peptidase activity
PI860_15665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PI860_15670	COG1393	Belongs to the ArsC family
PI860_15675	COG0583	DNA-binding transcription factor activity
PI860_15690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PI860_15695	COG0017	Asparaginyl-tRNA synthetase
PI860_15715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PI860_15720	COG0156	8-amino-7-oxononanoate synthase activity
PI860_15725	COG2226	methyltransferase
PI860_15725	COG1073	alpha beta
PI860_15730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PI860_15735	COG0501	Belongs to the peptidase M48B family
PI860_15745	COG3217	Mosc domain protein beta barrel domain protein
PI860_15745	COG0633	Ferredoxin
PI860_15745	COG3217	Mosc domain protein beta barrel domain protein
PI860_15745	COG0633	Ferredoxin
PI860_15760	COG2841	Protein conserved in bacteria
PI860_15770	COG0534	Mate efflux family protein
PI860_15810	COG1309	transcriptional regulator
PI860_15825	COG0791	NLP P60 protein
PI860_15835	COG0583	DNA-binding transcription factor activity
PI860_15845	COG0450	alkyl hydroperoxide reductase
PI860_15865	COG0500	methyltransferase
PI860_15870	COG4106	trans-aconitate 2-methyltransferase activity
PI860_15880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PI860_15885	COG0217	transcriptional regulatory protein
PI860_15905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PI860_15915	COG4584	PFAM Integrase catalytic
PI860_15920	COG1484	DNA-dependent DNA replication
PI860_15935	COG0604	alcohol dehydrogenase
PI860_15935	COG3321	synthase
PI860_15950	COG0438	transferase activity, transferring glycosyl groups
PI860_15980	COG1846	Transcriptional regulator
PI860_15980	COG1940	carbohydrate kinase activity
PI860_15985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PI860_15990	COG0363	glucosamine-6-phosphate deaminase activity
PI860_15995	COG1263	PTS System
PI860_15995	COG2190	(PTS) system
PI860_15995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PI860_16005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI860_16010	COG0735	belongs to the Fur family
PI860_16020	COG0716	FMN binding
PI860_16035	COG0596	Alpha beta hydrolase
PI860_16040	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PI860_16045	COG0033	Phosphoglucomutase
PI860_16055	COG1846	Transcriptional regulator
PI860_16060	COG2951	lytic endotransglycosylase activity
PI860_16065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PI860_16070	COG4136	ATPase activity
PI860_16075	COG4135	transport system, permease component
PI860_16080	COG4134	Bacterial extracellular solute-binding protein
PI860_16085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PI860_16090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PI860_16100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI860_16105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PI860_16120	COG0729	surface antigen
PI860_16125	COG2911	Protein conserved in bacteria
PI860_16140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PI860_16165	COG1607	acyl-coa hydrolase
PI860_16170	COG3021	interspecies interaction between organisms
PI860_16175	COG0741	lytic transglycosylase activity
PI860_16175	COG1388	LysM domain
PI860_16180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PI860_16185	COG2226	methyltransferase
PI860_16190	COG0328	RNA-DNA hybrid ribonuclease activity
PI860_16195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PI860_16205	COG3437	response regulator, receiver
PI860_16205	COG0784	Response regulator, receiver
PI860_16210	COG1960	acyl-CoA dehydrogenase activity
PI860_16215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PI860_16220	COG0121	glutamine amidotransferase
PI860_16250	COG2197	response regulator
PI860_16255	COG3850	Histidine kinase
PI860_16260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PI860_16265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PI860_16275	COG0243	molybdopterin cofactor binding
PI860_16280	COG0437	4 iron, 4 sulfur cluster binding
PI860_16285	COG0348	domain, Protein
PI860_16295	COG3005	denitrification pathway
PI860_16300	COG0521	Mo-molybdopterin cofactor biosynthetic process
PI860_16305	COG0315	cyclic pyranopterin monophosphate synthase activity
PI860_16310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PI860_16315	COG0314	molybdopterin synthase activity
PI860_16330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PI860_16335	COG0596	Alpha beta hydrolase
PI860_16360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PI860_16370	COG0302	gtp cyclohydrolase
PI860_16375	COG0840	transmembrane signaling receptor activity
PI860_16380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PI860_16390	COG0583	DNA-binding transcription factor activity
PI860_16395	COG2353	YceI-like domain
PI860_16420	COG2195	Cleaves the N-terminal amino acid of tripeptides
PI860_16425	COG1166	arginine decarboxylase activity
PI860_16455	COG0346	lactoylglutathione lyase activity
PI860_16465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PI860_16475	COG1187	pseudouridine synthase activity
PI860_16480	COG2807	transmembrane transport
PI860_16490	COG0583	DNA-binding transcription factor activity
PI860_16510	COG2979	Protein of unknown function (DUF533)
PI860_16515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI860_16525	COG1294	oxidase, subunit
PI860_16535	COG2814	Major facilitator Superfamily
PI860_16540	COG0656	L-ascorbic acid biosynthetic process
PI860_16545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PI860_16575	COG0583	DNA-binding transcription factor activity
PI860_16580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PI860_16585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PI860_16590	COG2271	Major facilitator Superfamily
PI860_16595	COG1349	DNA-binding transcription factor activity
PI860_16605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PI860_16610	COG0584	glycerophosphoryl diester phosphodiesterase
PI860_16615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PI860_16620	COG0287	Prephenate dehydrogenase
PI860_16620	COG1605	Chorismate mutase
PI860_16630	COG3085	chromosome segregation
PI860_16635	COG4574	serine-type endopeptidase inhibitor activity
PI860_16655	COG1770	oligopeptidase
PI860_16660	COG4771	TonB-dependent receptor
PI860_16665	COG3083	sulfuric ester hydrolase activity
PI860_16670	COG3082	Protein of unknown function (DUF1414)
PI860_16675	COG3081	Nucleoid-associated protein
PI860_16680	COG2182	Extracellular solute-binding protein
PI860_16685	COG1175	transmembrane transport
PI860_16690	COG3833	ABC-type maltose transport systems, permease component
PI860_16695	COG3842	ATPase activity
PI860_16710	COG0628	permease
PI860_16715	COG0425	Belongs to the sulfur carrier protein TusA family
PI860_16720	COG4783	chaperone-mediated protein folding
PI860_16730	COG1393	Belongs to the ArsC family
PI860_16740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PI860_16745	COG2431	L-lysine efflux transmembrane transporter activity
PI860_16780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PI860_16795	COG2373	Large extracellular alpha-helical protein
PI860_16800	COG4953	penicillin-binding protein 1C
PI860_16810	COG0301	tRNA thio-modification
PI860_16810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PI860_16825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PI860_16830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PI860_16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PI860_16875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PI860_16895	COG0483	inositol monophosphate 1-phosphatase activity
PI860_16905	COG0625	glutathione transferase activity
PI860_16920	COG0601	transmembrane transport
PI860_16925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI860_16930	COG0444	Belongs to the ABC transporter superfamily
PI860_16935	COG2814	Major facilitator Superfamily
PI860_16940	COG0583	DNA-binding transcription factor activity
PI860_16945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PI860_16970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI860_16975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI860_16980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PI860_16985	COG0509	glycine decarboxylation via glycine cleavage system
PI860_16990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PI860_16990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PI860_17005	COG3634	alkyl hydroperoxide reductase activity
PI860_17015	COG0517	IMP dehydrogenase activity
PI860_17020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PI860_17025	COG0343	queuine tRNA-ribosyltransferase activity
PI860_17030	COG1862	Preprotein translocase
PI860_17035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PI860_17040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PI860_17045	COG2897	thiosulfate sulfurtransferase activity
PI860_17055	COG0826	peptidase U32
PI860_17060	COG0826	peptidase U32
PI860_17065	COG3154	lipid carrier protein
PI860_17085	COG1104	cysteine desulfurase activity
PI860_17090	COG0822	iron-sulfur transferase activity
PI860_17100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PI860_17105	COG0443	Heat shock 70 kDa protein
PI860_17110	COG0633	Ferredoxin
PI860_17120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PI860_17125	COG0105	UTP biosynthetic process
PI860_17130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PI860_17140	COG1426	Protein conserved in bacteria
PI860_17145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PI860_17150	COG0124	histidyl-tRNA synthetase
PI860_17155	COG2976	Protein conserved in bacteria
PI860_17165	COG1160	GTP binding
PI860_17170	COG1645	bacterial-type flagellum-dependent swarming motility
PI860_17180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PI860_17185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PI860_17185	COG0047	phosphoribosylformylglycinamidine synthase activity
PI860_17195	COG2354	Protein conserved in bacteria
PI860_17210	COG3150	esterase
PI860_17215	COG1252	NADH dehydrogenase
PI860_17220	COG0393	Putative heavy-metal-binding
PI860_17230	COG1619	proteins homologs of microcin C7 resistance protein MccF
PI860_17245	COG0527	aspartate kinase activity
PI860_17250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PI860_17250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PI860_17255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI860_17295	COG1285	pathogenesis
PI860_17310	COG0577	efflux transmembrane transporter activity
PI860_17355	COG0672	)-iron permease
PI860_17395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PI860_17400	COG0574	Belongs to the PEP-utilizing enzyme family
PI860_17400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PI860_17440	COG1464	Belongs to the NlpA lipoprotein family
PI860_17445	COG0671	phosphoesterase, PA-phosphatase related
PI860_17450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PI860_17455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PI860_17465	COG0101	tRNA pseudouridine synthase activity
PI860_17470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PI860_17475	COG0285	dihydrofolate synthase activity
PI860_17480	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
PI860_17485	COG2920	part of a sulfur-relay system
PI860_17490	COG1289	transmembrane transporter activity
PI860_17495	COG0670	Belongs to the BI1 family
PI860_17505	COG0840	transmembrane signaling receptor activity
PI860_17515	COG0564	pseudouridine synthase activity
PI860_17540	COG0625	glutathione transferase activity
PI860_17545	COG0625	glutathione transferase activity
PI860_17565	COG0367	asparagine synthase
PI860_17575	COG4651	solute:proton antiporter activity
PI860_17575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PI860_17580	COG0647	UMP catabolic process
PI860_17590	COG1902	pentaerythritol trinitrate reductase activity
PI860_17595	COG1253	flavin adenine dinucleotide binding
PI860_17605	COG0277	FAD linked oxidase domain protein
PI860_17605	COG0247	lactate metabolic process
PI860_17615	COG2050	protein possibly involved in aromatic compounds catabolism
PI860_17620	COG0513	Belongs to the DEAD box helicase family
PI860_17630	COG5001	Diguanylate cyclase
PI860_17630	COG3300	MHYT domain
PI860_17635	COG2056	Na+-H+ antiporter family
PI860_17640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PI860_17655	COG0346	lactoylglutathione lyase activity
PI860_17660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PI860_17665	COG4660	Part of a membrane complex involved in electron transport
PI860_17670	COG4659	FMN binding
PI860_17675	COG4658	electron transport chain
PI860_17685	COG2878	Part of a membrane complex involved in electron transport
PI860_17690	COG4657	Part of a membrane complex involved in electron transport
PI860_17695	COG0697	spore germination
PI860_17740	COG0659	secondary active sulfate transmembrane transporter activity
PI860_17810	COG3829	transcription factor binding
PI860_17870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PI860_17875	COG1278	Cold shock
PI860_17880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PI860_17885	COG0542	response to heat
PI860_17890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PI860_17895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PI860_17900	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PI860_17905	COG3134	Outer membrane lipoprotein
PI860_17910	COG3706	GGDEF domain
PI860_17915	COG0492	ferredoxin-NADP+ reductase activity
PI860_17930	COG0531	amino acid
PI860_17930	COG1674	ftsk spoiiie
PI860_17935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PI860_17940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PI860_17945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PI860_17950	COG1286	toxin biosynthetic process
PI860_17955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PI860_17965	COG4172	Belongs to the ABC transporter superfamily
PI860_17970	COG4172	Belongs to the ABC transporter superfamily
PI860_17975	COG4171	peptide transport system, permease
PI860_17980	COG4168	peptide transport system, permease
PI860_17990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PI860_17995	COG1842	Phage shock protein A
PI860_18010	COG3106	COG3106 Predicted ATPase
PI860_18015	COG3768	UPF0283 membrane protein
PI860_18025	COG2154	pterin-4-alpha-carbinolamine dehydratase
PI860_18040	COG2199	diguanylate cyclase activity
PI860_18050	COG0861	Integral membrane protein TerC family
PI860_18065	COG1022	Amp-dependent synthetase and ligase
PI860_18070	COG0295	cytidine deaminase activity
PI860_18075	COG1346	cytolysis
PI860_18080	COG1380	Effector of murein hydrolase LrgA
PI860_18095	COG2925	Exonuclease
PI860_18110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PI860_18115	COG0436	Aminotransferase
PI860_18125	COG0583	DNA-binding transcription factor activity
PI860_18130	COG2160	L-arabinose isomerase activity
PI860_18140	COG1069	ribulokinase activity
PI860_18145	COG1879	ABC-type sugar transport system periplasmic component
PI860_18150	COG1129	ABC transporter
PI860_18155	COG1172	Belongs to the binding-protein-dependent transport system permease family
PI860_18165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PI860_18170	COG1085	galactose-1-phosphate uridylyltransferase
PI860_18175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PI860_18180	COG1609	Transcriptional regulator
PI860_18185	COG4580	involved in the transport of maltose and maltodextrins
PI860_18225	COG2182	Extracellular solute-binding protein
PI860_18230	COG1175	transmembrane transport
PI860_18235	COG3833	ABC-type maltose transport systems, permease component
PI860_18240	COG3867	Arabinogalactan endo-beta-1,4-galactanase
PI860_18245	COG1874	Beta-galactosidase
PI860_18255	COG0469	pyruvate kinase activity
PI860_18260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PI860_18265	COG0254	rRNA binding
PI860_18280	COG1451	nucleotide metabolic process
PI860_18295	COG3069	C4-dicarboxylate transmembrane transporter activity
PI860_18305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI860_18305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PI860_18310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PI860_18335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PI860_18340	COG1053	succinate dehydrogenase
PI860_18350	COG0567	Dehydrogenase, E1 component
PI860_18355	COG0508	dehydrogenase complex catalyzes the overall conversion of
PI860_18360	COG0045	succinate-CoA ligase (ADP-forming) activity
PI860_18365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PI860_18370	COG2983	Belongs to the UPF0260 family
PI860_18375	COG1882	Formate acetyltransferase
PI860_18380	COG2116	formate transmembrane transporter activity
PI860_18385	COG1944	ATP diphosphatase activity
PI860_18390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PI860_18395	COG0612	Peptidase, M16
PI860_18410	COG2910	NAD(P)H-binding
PI860_18415	COG0583	DNA-binding transcription factor activity
PI860_18425	COG2207	Transcriptional regulator
PI860_18425	COG3708	Transcriptional regulator
PI860_18430	COG4774	siderophore transport
PI860_18440	COG0583	DNA-binding transcription factor activity
PI860_18445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PI860_18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI860_18475	COG3046	protein related to deoxyribodipyrimidine photolyase
PI860_18485	COG3033	Beta-eliminating lyase
PI860_18500	COG4235	cytochrome complex assembly
PI860_18500	COG3088	subunit of a heme lyase
PI860_18515	COG3301	Polysulphide reductase, NrfD
PI860_18520	COG0437	4 iron, 4 sulfur cluster binding
PI860_18525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PI860_18535	COG0247	lactate metabolic process
PI860_18540	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
PI860_18545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PI860_18550	COG3012	SEC-C Motif Domain Protein
PI860_18555	COG0840	transmembrane signaling receptor activity
PI860_18560	COG1846	Transcriptional regulator
PI860_18560	COG1940	carbohydrate kinase activity
PI860_18565	COG3290	protein histidine kinase activity
PI860_18570	COG4565	transcriptional regulatory protein
PI860_18590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PI860_18595	COG0569	domain protein
PI860_18595	COG2985	domain, Protein
PI860_18605	COG0556	nucleotide-excision repair
PI860_18615	COG0586	Pfam SNARE associated Golgi protein
PI860_18620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PI860_18625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PI860_18630	COG2186	Transcriptional regulator
PI860_18635	COG2719	SpoVR family
PI860_18645	COG2766	serine protein kinase
PI860_18650	COG0514	ATP-dependent DNA helicase (RecQ)
PI860_18655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PI860_18660	COG0814	amino acid
PI860_18695	COG0058	SHG alpha-glucan phosphorylase activity
PI860_18700	COG0471	metal ion transport
PI860_18705	COG3118	belongs to the thioredoxin family
PI860_18720	COG1132	(ABC) transporter
PI860_18730	COG2501	S4 domain
PI860_18740	COG3243	poly(R)-hydroxyalkanoic acid synthase
PI860_18760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PI860_18765	COG2329	Antibiotic biosynthesis monooxygenase
PI860_18805	COG1742	UPF0060 membrane protein
PI860_18820	COG0513	Belongs to the DEAD box helicase family
PI860_18825	COG0386	Belongs to the glutathione peroxidase family
PI860_18835	COG1181	Belongs to the D-alanine--D-alanine ligase family
PI860_18845	COG3148	PFAM DTW domain containing protein
PI860_18850	COG0730	response to heat
PI860_18855	COG0583	DNA-binding transcription factor activity
PI860_18870	COG3593	DNA synthesis involved in DNA repair
PI860_18925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PI860_18930	COG1011	Hydrolase
PI860_18980	COG0205	6-phosphofructokinase activity
PI860_18990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PI860_18995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PI860_19005	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
PI860_19010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PI860_19015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PI860_19075	COG4681	YaeQ
PI860_19095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI860_19115	COG3134	Outer membrane lipoprotein
PI860_19125	COG1288	antiporter activity
PI860_19135	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_19140	COG0583	DNA-binding transcription factor activity
PI860_19145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PI860_19150	COG0673	inositol 2-dehydrogenase activity
PI860_19155	COG0583	DNA-binding transcription factor activity
PI860_19165	COG1560	Kdo2-lipid A biosynthetic process
PI860_19170	COG1560	Kdo2-lipid A biosynthetic process
PI860_19185	COG2203	Gaf domain
PI860_19185	COG2199	diguanylate cyclase activity
PI860_19195	COG0417	DNA replication proofreading
PI860_19220	COG0534	Mate efflux family protein
PI860_19230	COG0307	riboflavin synthase, alpha
PI860_19240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PI860_19245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PI860_19250	COG0697	spore germination
PI860_19255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PI860_19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PI860_19305	COG3099	Belongs to the UPF0263 family
PI860_19310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PI860_19315	COG2894	cell division
PI860_19320	COG0850	regulation of cytokinetic process
PI860_19325	COG3100	YcgL domain-containing protein
PI860_19330	COG2951	lytic endotransglycosylase activity
PI860_19335	COG1760	l-serine dehydratase
PI860_19340	COG1760	l-serine dehydratase
PI860_19345	COG3123	guanosine phosphorylase activity
PI860_19365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PI860_19370	COG2067	long-chain fatty acid transport protein
PI860_19375	COG2067	long-chain fatty acid transport protein
PI860_19415	COG0714	Associated with various cellular activities
PI860_19420	COG0183	Belongs to the thiolase family
PI860_19425	COG1024	Enoyl-CoA hydratase
PI860_19425	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI860_19430	COG2824	Alkylphosphonate utilization operon protein PhnA
PI860_19450	COG1879	ABC-type sugar transport system periplasmic component
PI860_19455	COG1129	ABC transporter
PI860_19460	COG1172	Belongs to the binding-protein-dependent transport system permease family
PI860_19465	COG1172	Belongs to the binding-protein-dependent transport system permease family
PI860_19470	COG2203	Gaf domain
PI860_19470	COG4251	negative regulation of phosphorylation
PI860_19470	COG5001	Diguanylate cyclase
PI860_19470	COG3706	GGDEF domain
PI860_19475	COG2823	Periplasmic or secreted lipoprotein
PI860_19530	COG2378	regulation of single-species biofilm formation
PI860_19540	COG0140	phosphoribosyl-ATP diphosphatase activity
PI860_19540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PI860_19545	COG0107	imidazoleglycerol-phosphate synthase activity
PI860_19550	COG0784	Response regulator, receiver
PI860_19550	COG2198	Histidine kinase
PI860_19550	COG2205	protein histidine kinase activity
PI860_19555	COG2199	diguanylate cyclase activity
PI860_19560	COG3437	response regulator, receiver
PI860_19565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PI860_19570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PI860_19575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PI860_19575	COG0131	Imidazoleglycerol-phosphate dehydratase
PI860_19580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PI860_19585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PI860_19590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PI860_19600	COG1199	ATP-dependent helicase activity
PI860_19605	COG1214	PFAM Peptidase M22, glycoprotease
PI860_19615	COG2267	carboxylic ester hydrolase activity
PI860_19620	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_19640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PI860_19645	COG2832	Protein of unknown function (DUF454)
PI860_19650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PI860_19655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PI860_19660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PI860_19665	COG3314	Sporulation integral membrane protein YlbJ
PI860_19670	COG2197	response regulator
PI860_19675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PI860_19675	COG0617	tRNA 3'-terminal CCA addition
PI860_19675	COG0517	IMP dehydrogenase activity
PI860_19680	COG1643	Atp-dependent helicase
PI860_19690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PI860_19695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PI860_19700	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PI860_19705	COG0709	Synthesizes selenophosphate from selenide and ATP
PI860_19720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PI860_19730	COG1254	Belongs to the acylphosphatase family
PI860_19735	COG0625	glutathione transferase activity
PI860_19745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI860_19745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI860_19750	COG0489	protein tyrosine kinase activity
PI860_19755	COG0572	uridine kinase
PI860_19760	COG0717	Belongs to the dCTP deaminase family
PI860_19765	COG0306	phosphate transporter
PI860_19770	COG1530	ribonuclease E activity
PI860_19780	COG0546	phosphoglycolate phosphatase activity
PI860_19790	COG1399	metal-binding, possibly nucleic acid-binding protein
PI860_19795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PI860_19800	COG0416	fatty acid biosynthetic process
PI860_19805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PI860_19815	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_19820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PI860_19825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PI860_19830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PI860_19835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PI860_19840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PI860_19845	COG0470	DNA polymerase III
PI860_19850	COG0084	hydrolase, TatD family'
PI860_19865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PI860_19865	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PI860_19875	COG2995	paraquat-inducible protein a
PI860_19885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PI860_19935	COG4221	oxidoreductase activity
PI860_20010	COG4128	Pfam Zonular occludens toxin
PI860_20015	COG4584	PFAM Integrase catalytic
PI860_20020	COG1484	DNA-dependent DNA replication
PI860_20090	COG4128	Pfam Zonular occludens toxin
PI860_20105	COG1067	ATP-dependent peptidase activity
PI860_20110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PI860_20125	COG0488	(ABC) transporter
PI860_20135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PI860_20135	COG0116	Belongs to the methyltransferase superfamily
PI860_20145	COG0167	dihydroorotate dehydrogenase activity
PI860_20150	COG2902	Dehydrogenase
PI860_20160	COG0308	aminopeptidase N
PI860_20170	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PI860_20175	COG1956	GAF domain-containing protein
PI860_20185	COG3278	Belongs to the heme-copper respiratory oxidase family
PI860_20200	COG2010	Cytochrome c
PI860_20210	COG2217	Heavy metal translocating P-type atpase
PI860_20225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PI860_20230	COG0589	response to stress
PI860_20235	COG0037	tRNA processing
PI860_20250	COG0625	glutathione transferase activity
PI860_20255	COG1869	D-ribose catabolic process
PI860_20265	COG1172	Belongs to the binding-protein-dependent transport system permease family
PI860_20270	COG1879	ABC-type sugar transport system periplasmic component
PI860_20275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PI860_20280	COG1609	Transcriptional regulator
PI860_20285	COG2199	diguanylate cyclase activity
PI860_20315	COG0776	regulation of translation
PI860_20320	COG0072	phenylalanine-tRNA ligase activity
PI860_20320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI860_20325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PI860_20330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PI860_20335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PI860_20340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PI860_20345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PI860_20370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PI860_20380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PI860_20385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PI860_20390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI860_20395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PI860_20400	COG3313	Fe-S protein
PI860_20405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PI860_20405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PI860_20405	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PI860_20410	COG1105	Belongs to the carbohydrate kinase PfkB family
PI860_20415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_20415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI860_20420	COG1609	Transcriptional regulator
PI860_20425	COG0814	amino acid
PI860_20435	COG5654	RES domain protein
PI860_20440	COG0513	Belongs to the DEAD box helicase family
PI860_20450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PI860_20455	COG2890	protein-(glutamine-N5) methyltransferase activity
PI860_20460	COG2840	Smr protein MutS2
PI860_20465	COG3706	GGDEF domain
PI860_20520	COG0730	response to heat
PI860_20530	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_20540	COG1024	Enoyl-CoA hydratase
PI860_20545	COG1024	Enoyl-CoA hydratase
PI860_20550	COG1960	acyl-CoA dehydrogenase activity
PI860_20560	COG1960	acyl-CoA dehydrogenase activity
PI860_20565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PI860_20570	COG1024	Enoyl-CoA hydratase
PI860_20600	COG1584	GPR1 FUN34 yaaH family protein
PI860_20610	COG0456	acetyltransferase
PI860_20615	COG1115	amino acid carrier protein
PI860_20620	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI860_20620	COG1024	Enoyl-CoA hydratase
PI860_20635	COG3162	membrane
PI860_20640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI860_20645	COG0488	(ABC) transporter
PI860_20650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PI860_20655	COG0776	regulation of translation
PI860_20660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PI860_20665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PI860_20670	COG0740	serine-type endopeptidase activity
PI860_20675	COG0544	peptidyl-prolyl cis-trans isomerase activity
PI860_20685	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PI860_20690	COG4591	ABC-type transport system involved in lipoprotein release permease component
PI860_20695	COG1136	(ABC) transporter
PI860_20700	COG4591	ABC-type transport system involved in lipoprotein release permease component
PI860_20710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PI860_20715	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PI860_20720	COG4166	transmembrane transport
PI860_20725	COG0697	spore germination
PI860_20735	COG2062	phosphohistidine phosphatase, SixA
PI860_20740	COG1025	Belongs to the peptidase M16 family
PI860_20775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PI860_20775	COG0519	Catalyzes the synthesis of GMP from XMP
PI860_20780	COG0516	GMP reductase activity
PI860_20780	COG0517	IMP dehydrogenase activity
PI860_20800	COG3038	cytochrome b561
PI860_20805	COG1570	exodeoxyribonuclease VII activity
PI860_20820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PI860_20825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PI860_20830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PI860_20870	COG4771	TonB-dependent receptor
PI860_20875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI860_20880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI860_20885	COG1120	ATPase activity
PI860_20890	COG2977	Belongs to the P-Pant transferase superfamily
PI860_20895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PI860_20900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PI860_20900	COG3321	synthase
PI860_20900	COG0300	oxidoreductase activity
PI860_20900	COG0318	PFAM AMP-dependent synthetase and ligase
PI860_20900	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_20910	COG1028	Short-chain dehydrogenase reductase Sdr
PI860_20915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PI860_20920	COG1535	isochorismatase
PI860_20920	COG3433	isochorismatase activity
PI860_20925	COG1021	2,3-dihydroxybenzoate-AMP ligase
PI860_20945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PI860_20950	COG5001	Diguanylate cyclase
PI860_20950	COG3300	MHYT domain
PI860_20965	COG0840	transmembrane signaling receptor activity
PI860_20970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PI860_20975	COG3788	relative of glutathione S-transferase, MAPEG superfamily
PI860_20980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PI860_20985	COG0563	adenylate kinase activity
PI860_20990	COG0326	Molecular chaperone. Has ATPase activity
PI860_20995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PI860_21020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PI860_21040	COG3158	transport of potassium into the cell
PI860_21045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PI860_21050	COG0651	ATP synthesis coupled electron transport
PI860_21055	COG0650	Formate hydrogenlyase subunit 4
PI860_21060	COG3261	NADH dehydrogenase
PI860_21060	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PI860_21065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21070	COG3260	NADH ubiquinone oxidoreductase 20
PI860_21080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PI860_21090	COG1921	L-seryl-tRNASec selenium transferase activity
PI860_21100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PI860_21105	COG0298	carbon dioxide binding
PI860_21115	COG0309	Hydrogenase expression formation protein (HypE)
PI860_21120	COG0375	protein maturation
PI860_21125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PI860_21140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI860_21145	COG0601	transmembrane transport
PI860_21155	COG1773	rubredoxin
PI860_21160	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PI860_21165	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PI860_21170	COG5557	Pfam Polysulphide reductase, NrfD
PI860_21175	COG0437	4 iron, 4 sulfur cluster binding
PI860_21180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
PI860_21185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PI860_21210	COG1435	thymidine kinase activity
PI860_21215	COG1757	Na H antiporter
PI860_21225	COG2916	Histone family protein nucleoid-structuring protein H-NS
PI860_21230	COG2096	Adenosyltransferase
PI860_21235	COG3530	Putative quorum-sensing-regulated virulence factor
PI860_21240	COG0602	queuosine metabolic process
PI860_21245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PI860_21260	COG0284	orotidine-5'-phosphate decarboxylase activity
PI860_21265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PI860_21275	COG0776	regulation of translation
PI860_21280	COG0539	negative regulation of cytoplasmic translation
PI860_21285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PI860_21290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI860_21300	COG0583	DNA-binding transcription factor activity
PI860_21305	COG2814	Major facilitator Superfamily
PI860_21340	COG0583	DNA-binding transcription factor activity
PI860_21345	COG3437	response regulator, receiver
PI860_21370	COG4989	oxidoreductase activity
PI860_21375	COG0724	RNA recognition motif
PI860_21385	COG1126	abc transporter atp-binding protein
PI860_21390	COG0765	amino acid transport
PI860_21395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_21400	COG4597	amino acid ABC transporter
PI860_21415	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PI860_21430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PI860_21435	COG1360	Flagellar Motor Protein
PI860_21440	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21450	COG0649	NAD binding
PI860_21450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21465	COG1034	ATP synthesis coupled electron transport
PI860_21470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PI860_21475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21480	COG0839	Belongs to the complex I subunit 6 family
PI860_21485	COG0713	ATP synthesis coupled electron transport
PI860_21495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI860_21500	COG1007	ATP synthesis coupled electron transport
PI860_21520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PI860_21525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PI860_21560	COG0537	adenosine 5'-monophosphoramidase activity
PI860_21575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PI860_21590	COG1301	dicarboxylic acid transport
PI860_21600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PI860_21605	COG0861	Integral membrane protein TerC family
PI860_21620	COG0444	Belongs to the ABC transporter superfamily
PI860_21625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI860_21630	COG0601	transmembrane transport
PI860_21640	COG2095	MarC family integral membrane protein
PI860_21650	COG1454	alcohol dehydrogenase
PI860_21650	COG1012	belongs to the aldehyde dehydrogenase family
PI860_21660	COG3275	phosphorelay sensor kinase activity
PI860_21665	COG3279	Response regulator of the LytR AlgR family
PI860_21670	COG1966	Carbon starvation protein
PI860_21680	COG1566	PFAM secretion protein HlyD family protein
PI860_21685	COG1061	Type III restriction enzyme res subunit
PI860_21690	COG2027	D-alanyl-D-alanine carboxypeptidase
PI860_21695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PI860_21705	COG0436	Aminotransferase
PI860_21710	COG1288	antiporter activity
PI860_21715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PI860_21800	COG1242	4 iron, 4 sulfur cluster binding
PI860_21805	COG0069	glutamate synthase activity
PI860_21805	COG0070	glutamate synthase
PI860_21805	COG0067	glutamate synthase
PI860_21810	COG0493	'glutamate synthase
PI860_21825	COG0789	Transcriptional regulator
PI860_21850	COG0513	Belongs to the DEAD box helicase family
PI860_21855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PI860_21895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PI860_21900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PI860_21905	COG0505	Belongs to the CarA family
PI860_21910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PI860_21930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PI860_21935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PI860_21940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PI860_21945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PI860_21950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PI860_21955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
PI860_21965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI860_21965	COG2205	protein histidine kinase activity
PI860_22010	COG2119	membrane
PI860_22070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PI860_22080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI860_22110	COG4974	Belongs to the 'phage' integrase family
PI860_22120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PI860_22190	COG4695	Portal protein
PI860_22365	COG3328	transposase activity
PI860_22395	COG1317	bacterial-type flagellum organization
PI860_22485	COG0457	Tetratricopeptide repeat
PI860_22555	COG4790	Type iii secretion
PI860_22560	COG4794	Type iii secretion
PI860_22565	COG4791	protein targeting
PI860_22570	COG4792	protein secretion
PI860_22605	COG3328	transposase activity
PI860_22610	COG1484	DNA-dependent DNA replication
PI860_22615	COG4584	PFAM Integrase catalytic
PI860_22810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PI860_22875	COG2003	Belongs to the UPF0758 family
PI860_22915	COG4584	PFAM Integrase catalytic
PI860_22920	COG1484	DNA-dependent DNA replication
PI860_22945	COG2194	sulfuric ester hydrolase activity
PI860_22950	COG2194	sulfuric ester hydrolase activity
PI860_22960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PI860_22965	COG1192	Involved in chromosome partitioning
PI860_22995	COG2916	Histone family protein nucleoid-structuring protein H-NS
PI860_23005	COG1192	Involved in chromosome partitioning
PI860_23015	COG3328	transposase activity
PI860_23045	COG0393	Putative heavy-metal-binding
PI860_23070	COG1484	DNA-dependent DNA replication
PI860_23075	COG4584	PFAM Integrase catalytic
PI860_23100	COG2916	Histone family protein nucleoid-structuring protein H-NS
PI860_23115	COG1192	Involved in chromosome partitioning
PI860_23225	COG2026	Addiction module toxin, RelE StbE family
PI860_23230	COG3077	Addiction module antitoxin, RelB DinJ family
PI860_23355	COG3328	transposase activity