locus-tag	class	description
GO994_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO994_00010	COG0592	DNA-directed DNA polymerase activity
GO994_00020	COG0187	DNA topoisomerase II activity
GO994_00035	COG2378	regulation of single-species biofilm formation
GO994_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GO994_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
GO994_00060	COG3977	Valine--pyruvate aminotransferase
GO994_00075	COG2814	Major facilitator Superfamily
GO994_00085	COG0745	RESPONSE REGULATOR receiver
GO994_00090	COG2205	protein histidine kinase activity
GO994_00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO994_00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_00120	COG4191	Histidine kinase
GO994_00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO994_00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_00135	COG1309	transcriptional regulator
GO994_00165	COG0561	phosphatase activity
GO994_00170	COG2267	carboxylic ester hydrolase activity
GO994_00175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO994_00180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO994_00185	COG1758	RNA polymerase activity
GO994_00190	COG0194	GDP metabolic process
GO994_00200	COG0859	PFAM glycosyl transferase family 9
GO994_00205	COG3642	lipopolysaccharide core region biosynthetic process
GO994_00245	COG0589	response to stress
GO994_00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO994_00255	COG3706	GGDEF domain
GO994_00260	COG1528	Iron-storage protein
GO994_00265	COG2081	HI0933 family
GO994_00310	COG5433	transposase activity
GO994_00315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_00315	COG2205	protein histidine kinase activity
GO994_00325	COG3275	phosphorelay sensor kinase activity
GO994_00330	COG3279	Response regulator of the LytR AlgR family
GO994_00335	COG2223	nitrite transmembrane transporter activity
GO994_00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO994_00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO994_00360	COG0583	DNA-binding transcription factor activity
GO994_00365	COG4206	TonB-dependent receptor
GO994_00370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO994_00400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO994_00400	COG1042	CoA-binding domain protein
GO994_00400	COG0045	succinate-CoA ligase (ADP-forming) activity
GO994_00415	COG0583	DNA-binding transcription factor activity
GO994_00420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO994_00425	COG0166	Belongs to the GPI family
GO994_00435	COG0668	transmembrane transport
GO994_00440	COG1309	transcriptional regulator
GO994_00445	COG0756	dUTP diphosphatase activity
GO994_00450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO994_00455	COG2003	Belongs to the UPF0758 family
GO994_00460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO994_00465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO994_00475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO994_00480	COG2990	Protein conserved in bacteria
GO994_00485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO994_00490	COG0859	PFAM glycosyl transferase family 9
GO994_00495	COG0463	Glycosyl transferase, family 2
GO994_00500	COG0859	PFAM glycosyl transferase family 9
GO994_00505	COG1519	Transferase
GO994_00520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_00525	COG1609	Transcriptional regulator
GO994_00550	COG1580	Controls the rotational direction of flagella during chemotaxis
GO994_00555	COG3161	chorismate lyase activity
GO994_00560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO994_00565	COG2937	Belongs to the GPAT DAPAT family
GO994_00570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO994_00585	COG0534	Mate efflux family protein
GO994_00590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO994_00595	COG2205	protein histidine kinase activity
GO994_00600	COG0745	RESPONSE REGULATOR receiver
GO994_00610	COG1045	serine acetyltransferase
GO994_00620	COG3074	FtsZ-dependent cytokinesis
GO994_00625	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GO994_00635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO994_00685	COG1609	Transcriptional regulator
GO994_00695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO994_00715	COG0583	DNA-binding transcription factor activity
GO994_00740	COG0210	DNA helicase
GO994_00780	COG1280	lysine exporter protein (LysE YggA)
GO994_00785	COG2391	methyltransferase activity
GO994_00790	COG5433	transposase activity
GO994_00810	COG0519	Catalyzes the synthesis of GMP from XMP
GO994_00810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO994_00815	COG0686	Belongs to the AlaDH PNT family
GO994_00820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO994_00840	COG1322	Protein conserved in bacteria
GO994_00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO994_00850	COG0569	domain protein
GO994_00855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO994_00855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO994_00860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO994_00865	COG0242	peptide deformylase activity
GO994_00870	COG1652	LysM domain
GO994_00895	COG2922	Belongs to the Smg family
GO994_00900	COG0551	DNA topoisomerase type I activity
GO994_00910	COG0009	L-threonylcarbamoyladenylate synthase
GO994_00915	COG0408	coproporphyrinogen oxidase activity
GO994_00920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO994_00940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO994_00950	COG3078	GTPase activator activity
GO994_00960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO994_00965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO994_00970	COG2204	response regulator
GO994_00975	COG3852	Histidine kinase
GO994_00985	COG0174	glutamine synthetase
GO994_00995	COG1295	ribonuclease BN
GO994_01000	COG1490	D-aminoacyl-tRNA deacylase activity
GO994_01010	COG0456	acetyltransferase
GO994_01020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO994_01025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO994_01030	COG2610	gluconate transmembrane transporter activity
GO994_01035	COG3265	gluconokinase activity
GO994_01040	COG0129	dihydroxy-acid dehydratase activity
GO994_01045	COG0800	Aldolase
GO994_01050	COG1609	Transcriptional regulator
GO994_01060	COG4942	peptidase
GO994_01065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO994_01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO994_01075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO994_01080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO994_01085	COG0316	Belongs to the HesB IscA family
GO994_01085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO994_01090	COG1040	competence protein
GO994_01095	COG0596	Alpha beta hydrolase
GO994_01115	COG2183	response to ionizing radiation
GO994_01120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO994_01125	COG0745	RESPONSE REGULATOR receiver
GO994_01140	COG0051	transcription antitermination factor activity, RNA binding
GO994_01145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO994_01150	COG0088	Forms part of the polypeptide exit tunnel
GO994_01155	COG0089	rRNA binding
GO994_01160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO994_01165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO994_01170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO994_01175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GO994_01180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO994_01185	COG0255	Belongs to the universal ribosomal protein uL29 family
GO994_01190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO994_01195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO994_01200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO994_01205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO994_01210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO994_01215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO994_01220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO994_01225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO994_01230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO994_01235	COG1841	ribosomal large subunit assembly
GO994_01240	COG0200	Binds to the 23S rRNA
GO994_01245	COG0201	protein transport
GO994_01250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO994_01255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO994_01260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO994_01265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO994_01270	COG0202	RNA polymerase activity
GO994_01275	COG0203	ribosomal protein L17
GO994_01320	COG2252	PERMEase
GO994_01325	COG2376	Dihydroxyacetone kinase
GO994_01330	COG1461	Dihydroxyacetone kinase
GO994_01335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_01335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO994_01335	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GO994_01345	COG3284	Transcriptional regulator
GO994_01350	COG0628	permease
GO994_01360	COG5433	transposase activity
GO994_01375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO994_01380	COG1288	antiporter activity
GO994_01390	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO994_01395	COG0540	Belongs to the ATCase OTCase family
GO994_01410	COG0688	phosphatidylethanolamine metabolic process
GO994_01420	COG3040	lipid binding
GO994_01430	COG1979	alcohol dehydrogenase
GO994_01435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GO994_01440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO994_01450	COG2964	Protein conserved in bacteria
GO994_01455	COG3681	Belongs to the UPF0597 family
GO994_01465	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO994_01470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO994_01475	COG0564	pseudouridine synthase activity
GO994_01485	COG0542	response to heat
GO994_01490	COG2502	aspartate--ammonia ligase
GO994_01495	COG1522	sequence-specific DNA binding
GO994_01505	COG5413	integral membrane protein
GO994_01510	COG0516	GMP reductase activity
GO994_01510	COG0517	IMP dehydrogenase activity
GO994_01515	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_01530	COG2205	protein histidine kinase activity
GO994_01540	COG2204	response regulator
GO994_01555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO994_01560	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GO994_01575	COG0745	RESPONSE REGULATOR receiver
GO994_01580	COG2205	protein histidine kinase activity
GO994_01590	COG0243	molybdopterin cofactor binding
GO994_01595	COG3005	denitrification pathway
GO994_01600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO994_01605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO994_01610	COG0569	domain protein
GO994_01615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO994_01640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO994_01650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO994_01655	COG0250	Participates in transcription elongation, termination and antitermination
GO994_01660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GO994_01665	COG0081	regulation of translation
GO994_01670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO994_01675	COG0222	ribosome binding
GO994_01680	COG0085	RNA polymerase activity
GO994_01685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO994_01690	COG2964	Protein conserved in bacteria
GO994_01695	COG0251	oxidation-reduction process
GO994_01705	COG2923	Belongs to the DsrF TusC family
GO994_01710	COG2168	tRNA wobble position uridine thiolation
GO994_01715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO994_01720	COG0049	tRNA binding
GO994_01725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO994_01730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO994_01735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO994_01800	COG3047	cAMP biosynthetic process
GO994_01830	COG3135	benzoate transporter
GO994_01835	COG1396	sequence-specific DNA binding
GO994_01865	COG2926	Belongs to the UPF0265 family
GO994_01875	COG3028	Belongs to the UPF0307 family
GO994_01880	COG0312	modulator of DNA gyrase
GO994_01885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO994_01890	COG5007	Belongs to the BolA IbaG family
GO994_01900	COG2854	intermembrane phospholipid transfer
GO994_01905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO994_01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO994_01915	COG1127	ABC transporter
GO994_01920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO994_01920	COG0517	IMP dehydrogenase activity
GO994_01925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO994_01930	COG3117	lipopolysaccharide transmembrane transporter activity
GO994_01935	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO994_01940	COG1137	ATPase activity
GO994_01945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO994_01955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_01960	COG1660	Displays ATPase and GTPase activities
GO994_01965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_01985	COG3964	amidohydrolase
GO994_02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO994_02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO994_02035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO994_02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO994_02045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO994_02050	COG0723	plastoquinol--plastocyanin reductase activity
GO994_02055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO994_02060	COG2857	Cytochrome c1
GO994_02065	COG0625	glutathione transferase activity
GO994_02070	COG2969	positive regulation of protein catabolic process
GO994_02075	COG2823	Periplasmic or secreted lipoprotein
GO994_02080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO994_02090	COG3107	peptidoglycan biosynthetic process
GO994_02095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO994_02120	COG1987	bacterial-type flagellum assembly
GO994_02140	COG2204	response regulator
GO994_02145	COG1677	Flagellar hook-basal body complex protein FliE
GO994_02155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO994_02185	COG2747	anti-sigma28 factor FlgM
GO994_02195	COG1815	bacterial-type flagellum-dependent cell motility
GO994_02200	COG1558	bacterial-type flagellum-dependent cell motility
GO994_02205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO994_02210	COG1749	Flagellar hook protein flgE
GO994_02215	COG4786	Flagellar basal body rod
GO994_02220	COG4786	Flagellar basal body rod
GO994_02225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO994_02230	COG1706	bacterial-type flagellum-dependent cell motility
GO994_02240	COG4786	Flagellar basal body rod
GO994_02240	COG1256	bacterial-type flagellum assembly
GO994_02270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO994_02300	COG1191	sigma factor activity
GO994_02305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO994_02310	COG1360	Flagellar Motor Protein
GO994_02315	COG1388	LysM domain
GO994_02315	COG0741	lytic transglycosylase activity
GO994_02325	COG2001	Belongs to the MraZ family
GO994_02330	COG0275	rRNA processing
GO994_02335	COG3116	cell division
GO994_02340	COG0768	penicillin binding
GO994_02350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO994_02355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO994_02360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO994_02365	COG0772	Belongs to the SEDS family
GO994_02370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO994_02375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO994_02380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO994_02385	COG0849	cell division
GO994_02390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO994_02395	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO994_02405	COG0653	protein targeting
GO994_02415	COG0494	nUDIX hydrolase
GO994_02420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO994_02425	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GO994_02435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GO994_02445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO994_02470	COG2186	Transcriptional regulator
GO994_02475	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GO994_02480	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO994_02485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO994_02490	COG5002	protein histidine kinase activity
GO994_02490	COG3447	MASE1 domain protein
GO994_02490	COG5001	Diguanylate cyclase
GO994_02500	COG0840	transmembrane signaling receptor activity
GO994_02505	COG0840	transmembrane signaling receptor activity
GO994_02515	COG1049	propionate catabolic process, 2-methylcitrate cycle
GO994_02525	COG5433	transposase activity
GO994_02550	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_02555	COG0583	DNA-binding transcription factor activity
GO994_02565	COG1280	lysine exporter protein (LysE YggA)
GO994_02575	COG0523	cobalamin synthesis protein
GO994_02605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO994_02610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO994_02710	COG0189	ligase activity
GO994_02720	COG0745	RESPONSE REGULATOR receiver
GO994_02760	COG1639	'signal transduction protein
GO994_02770	COG3700	Belongs to the class B bacterial acid phosphatase family
GO994_02780	COG1366	Belongs to the anti-sigma-factor antagonist family
GO994_02785	COG2172	sigma factor antagonist activity
GO994_02790	COG2205	protein histidine kinase activity
GO994_02790	COG5002	protein histidine kinase activity
GO994_02790	COG0784	Response regulator, receiver
GO994_02795	COG3437	response regulator, receiver
GO994_02805	COG0477	Major facilitator Superfamily
GO994_02820	COG0312	modulator of DNA gyrase
GO994_02825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO994_02835	COG3164	Protein of unknown function
GO994_02840	COG1530	ribonuclease E activity
GO994_02845	COG0424	maF-like protein
GO994_02850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO994_02855	COG1792	Involved in formation and maintenance of cell shape
GO994_02860	COG1077	Cell shape determining protein MreB Mrl
GO994_02915	COG2200	EAL domain
GO994_02915	COG2199	diguanylate cyclase activity
GO994_02925	COG0387	Pfam Sodium calcium exchanger
GO994_02930	COG2986	histidine ammonia-lyase
GO994_02935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GO994_02940	COG0010	Belongs to the arginase family
GO994_02945	COG1228	amidohydrolase
GO994_02950	COG2188	Transcriptional regulator
GO994_02955	COG0288	reversible hydration of carbon dioxide
GO994_02965	COG2177	Part of the ABC transporter FtsEX involved in
GO994_02970	COG2884	Cell division ATP-binding protein ftsE
GO994_02975	COG0552	protein localization to endoplasmic reticulum
GO994_02980	COG0742	ribosomal rna small subunit methyltransferase
GO994_03010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO994_03015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO994_03025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO994_03035	COG2095	MarC family integral membrane protein
GO994_03045	COG1301	dicarboxylic acid transport
GO994_03070	COG3714	YhhN family
GO994_03095	COG1770	oligopeptidase
GO994_03110	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO994_03170	COG0513	Belongs to the DEAD box helicase family
GO994_03190	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GO994_03250	COG2816	NAD+ diphosphatase activity
GO994_03255	COG2205	protein histidine kinase activity
GO994_03260	COG0745	RESPONSE REGULATOR receiver
GO994_03265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_03275	COG1505	serine-type exopeptidase activity
GO994_03280	COG2982	Protein involved in outer membrane biogenesis
GO994_03290	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_03295	COG5433	transposase activity
GO994_03310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO994_03335	COG5433	transposase activity
GO994_03340	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_03360	COG1349	DNA-binding transcription factor activity
GO994_03365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO994_03395	COG2130	NADP-dependent
GO994_03400	COG1764	response to oxidative stress
GO994_03405	COG1846	Transcriptional regulator
GO994_03435	COG0561	phosphatase activity
GO994_03450	COG0733	neurotransmitter:sodium symporter activity
GO994_03460	COG0733	neurotransmitter:sodium symporter activity
GO994_03485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO994_03500	COG1794	racemase activity, acting on amino acids and derivatives
GO994_03510	COG2731	YhcH YjgK YiaL family protein
GO994_03520	COG0668	transmembrane transport
GO994_03525	COG1376	ErfK ybiS ycfS ynhG family protein
GO994_03530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO994_03540	COG0789	Transcriptional regulator
GO994_03545	COG5433	transposase activity
GO994_03560	COG5433	transposase activity
GO994_03620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO994_03630	COG0488	(ABC) transporter
GO994_03635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO994_03635	COG0517	IMP dehydrogenase activity
GO994_03640	COG1585	Membrane protein implicated in regulation of membrane protease activity
GO994_03645	COG0330	HflC and HflK could
GO994_03655	COG0175	sulfate reduction
GO994_03660	COG2895	sulfate adenylyltransferase (ATP) activity
GO994_03665	COG0471	metal ion transport
GO994_03665	COG3273	potassium ion transport
GO994_03670	COG0529	Catalyzes the synthesis of activated sulfate
GO994_03690	COG3328	transposase activity
GO994_03695	COG5433	transposase activity
GO994_03730	COG0840	transmembrane signaling receptor activity
GO994_03765	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GO994_03785	COG1940	carbohydrate kinase activity
GO994_03790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO994_03795	COG0126	phosphoglycerate kinase activity
GO994_03800	COG0191	fructose-bisphosphate aldolase activity
GO994_03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO994_03855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GO994_03860	COG1595	DNA-templated transcription, initiation
GO994_03865	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GO994_03880	COG0481	GTPase activity
GO994_03885	COG0681	Belongs to the peptidase S26 family
GO994_03890	COG0571	ribonuclease III activity
GO994_03900	COG1381	Involved in DNA repair and RecF pathway recombination
GO994_03905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO994_03910	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO994_03915	COG4807	Protein conserved in bacteria
GO994_03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO994_03930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO994_03935	COG3956	TIGRFAM MazG family protein
GO994_03940	COG0504	CTP synthase activity
GO994_03945	COG0148	phosphopyruvate hydratase activity
GO994_03950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO994_03955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO994_03965	COG0585	pseudouridine synthase activity
GO994_03970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO994_03975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO994_03980	COG1238	metal cluster binding
GO994_03985	COG4942	peptidase
GO994_03985	COG1388	LysM domain
GO994_03995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO994_04000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO994_04005	COG1610	YqeY-like protein
GO994_04010	COG0358	DNA primase activity
GO994_04015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO994_04055	COG0151	Belongs to the GarS family
GO994_04060	COG0138	bifunctional purine biosynthesis protein purh
GO994_04070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO994_04075	COG3036	rescue of stalled ribosome
GO994_04080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO994_04085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO994_04095	COG0673	inositol 2-dehydrogenase activity
GO994_04110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO994_04115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO994_04120	COG3227	Zinc metalloprotease (Elastase)
GO994_04130	COG0477	Major facilitator Superfamily
GO994_04140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO994_04145	COG1027	Aspartate ammonia-lyase
GO994_04150	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO994_04160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO994_04165	COG0459	protein refolding
GO994_04175	COG3300	MHYT domain
GO994_04175	COG5001	Diguanylate cyclase
GO994_04185	COG0564	pseudouridine synthase activity
GO994_04190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO994_04215	COG1280	lysine exporter protein (LysE YggA)
GO994_04220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GO994_04235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_04265	COG0745	RESPONSE REGULATOR receiver
GO994_04270	COG3104	oligopeptide transport
GO994_04275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO994_04280	COG1555	photosystem II stabilization
GO994_04290	COG2350	Protein conserved in bacteria
GO994_04295	COG2917	probably involved in intracellular septation
GO994_04300	COG0076	glutamate decarboxylase activity
GO994_04305	COG1272	protein, Hemolysin III
GO994_04310	COG2985	domain, Protein
GO994_04310	COG0569	domain protein
GO994_04320	COG0784	Response regulator, receiver
GO994_04320	COG0835	chemotaxis
GO994_04325	COG2755	lipolytic protein G-D-S-L family
GO994_04330	COG4181	ATPase activity
GO994_04335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO994_04340	COG1090	epimerase
GO994_04345	COG2200	EAL domain
GO994_04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO994_04355	COG2234	aminopeptidase activity
GO994_04355	COG4935	Belongs to the peptidase S8 family
GO994_04360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO994_04365	COG3171	Protein conserved in bacteria
GO994_04375	COG2897	thiosulfate sulfurtransferase activity
GO994_04385	COG1132	(ABC) transporter
GO994_04395	COG1012	belongs to the aldehyde dehydrogenase family
GO994_04400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GO994_04425	COG4412	M6 family metalloprotease domain protein
GO994_04425	COG3291	Pkd domain containing protein
GO994_04430	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GO994_04435	COG3300	MHYT domain
GO994_04435	COG5001	Diguanylate cyclase
GO994_04455	COG4628	conserved protein (DUF2132)
GO994_04460	COG0688	phosphatidylethanolamine metabolic process
GO994_04470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GO994_04500	COG1278	Cold shock
GO994_04515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO994_04570	COG0848	biopolymer transport protein
GO994_04575	COG0811	peptide transport
GO994_04580	COG0811	peptide transport
GO994_04590	COG4206	TonB-dependent receptor
GO994_04610	COG4239	(ABC) transporter, permease
GO994_04615	COG0747	negative chemotaxis
GO994_04620	COG0444	Belongs to the ABC transporter superfamily
GO994_04625	COG4608	Belongs to the ABC transporter superfamily
GO994_04635	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO994_04650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO994_04665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO994_04670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO994_04700	COG1522	sequence-specific DNA binding
GO994_04700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO994_04720	COG1858	cytochrome C peroxidase
GO994_04760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO994_04765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO994_04775	COG0318	PFAM AMP-dependent synthetase and ligase
GO994_04780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO994_04790	COG2986	histidine ammonia-lyase
GO994_04815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO994_04825	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_04830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO994_04840	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO994_04860	COG5433	transposase activity
GO994_04870	COG2966	Psort location CytoplasmicMembrane, score
GO994_04875	COG3610	response to peptide
GO994_04885	COG4175	Glycine betaine
GO994_04890	COG4176	ABC-type proline glycine betaine transport system permease component
GO994_04895	COG2113	Glycine betaine
GO994_04900	COG0175	sulfate reduction
GO994_04905	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO994_04910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO994_04915	COG0384	phenazine biosynthesis protein PhzF
GO994_04920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO994_04935	COG0786	glutamate:sodium symporter activity
GO994_04940	COG0252	asparaginase activity
GO994_04945	COG3139	Protein of unknown function (DUF1315)
GO994_04965	COG0616	signal peptide processing
GO994_04970	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO994_04970	COG1902	pentaerythritol trinitrate reductase activity
GO994_04975	COG0778	Nitroreductase
GO994_04995	COG4302	ethanolamine ammonia-lyase activity
GO994_05000	COG4303	Ethanolamine ammonia lyase large subunit
GO994_05005	COG0531	amino acid
GO994_05010	COG2264	protein methyltransferase activity
GO994_05015	COG0604	alcohol dehydrogenase
GO994_05025	COG0583	DNA-binding transcription factor activity
GO994_05030	COG2190	(PTS) system
GO994_05030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO994_05030	COG1263	PTS System
GO994_05035	COG4145	pantothenate transmembrane transporter activity
GO994_05040	COG3924	membrane
GO994_05045	COG0439	Biotin carboxylase
GO994_05050	COG0511	ligase activity, forming carbon-carbon bonds
GO994_05055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO994_05060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO994_05090	COG3381	protein complex oligomerization
GO994_05100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO994_05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO994_05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO994_05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO994_05135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO994_05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO994_05145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO994_05150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO994_05175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO994_05180	COG0142	geranyltranstransferase activity
GO994_05185	COG1722	exodeoxyribonuclease VII activity
GO994_05190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO994_05195	COG1360	Flagellar Motor Protein
GO994_05205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO994_05215	COG1534	Rna-binding protein
GO994_05220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GO994_05225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO994_05230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO994_05235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO994_05240	COG0149	triose-phosphate isomerase activity
GO994_05245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO994_05260	COG0779	Required for maturation of 30S ribosomal subunits
GO994_05265	COG0195	Participates in both transcription termination and antitermination
GO994_05270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO994_05275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO994_05280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO994_05285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO994_05290	COG1185	polyribonucleotide nucleotidyltransferase activity
GO994_05295	COG2211	Major facilitator Superfamily
GO994_05300	COG3706	GGDEF domain
GO994_05305	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO994_05310	COG1422	Protein of unknown function (DUF1090)
GO994_05385	COG0312	modulator of DNA gyrase
GO994_05395	COG0716	FMN binding
GO994_05400	COG4974	Belongs to the 'phage' integrase family
GO994_05420	COG1970	mechanosensitive ion channel activity
GO994_05425	COG5433	transposase activity
GO994_05435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO994_05450	COG3545	Serine hydrolase
GO994_05455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO994_05530	COG5433	transposase activity
GO994_05555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO994_05560	COG0321	lipoyl(octanoyl) transferase activity
GO994_05565	COG2921	Belongs to the UPF0250 family
GO994_05570	COG1686	Belongs to the peptidase S11 family
GO994_05575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO994_05580	COG2951	lytic endotransglycosylase activity
GO994_05585	COG0772	Belongs to the SEDS family
GO994_05590	COG0768	penicillin binding
GO994_05595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO994_05600	COG0799	negative regulation of ribosome biogenesis
GO994_05605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO994_05625	COG0495	leucyl-tRNA aminoacylation
GO994_05630	COG2888	peptidyl-tyrosine sulfation
GO994_05635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO994_05640	COG4535	Mg2 and Co2 transporter CorC
GO994_05645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO994_05650	COG1702	phosphate starvation-inducible protein PhoH
GO994_05655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO994_05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO994_05670	COG3706	GGDEF domain
GO994_05685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO994_05705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO994_05715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO994_05725	COG0516	GMP reductase activity
GO994_05740	COG0745	RESPONSE REGULATOR receiver
GO994_05775	COG3214	Protein conserved in bacteria
GO994_05795	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO994_05800	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO994_05805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO994_05810	COG1053	succinate dehydrogenase
GO994_05820	COG0584	glycerophosphoryl diester phosphodiesterase
GO994_05825	COG3264	Mechanosensitive ion channel
GO994_05825	COG1511	domain protein
GO994_05840	COG0739	heme binding
GO994_05855	COG0583	DNA-binding transcription factor activity
GO994_05870	COG0840	transmembrane signaling receptor activity
GO994_05875	COG0583	DNA-binding transcription factor activity
GO994_05880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO994_05910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO994_05915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO994_05925	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO994_05930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO994_05935	COG0546	phosphoglycolate phosphatase activity
GO994_05940	COG0180	Tryptophanyl-tRNA synthetase
GO994_05955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO994_05965	COG1012	belongs to the aldehyde dehydrogenase family
GO994_05975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO994_06010	COG3089	Belongs to the UPF0270 family
GO994_06035	COG0429	hydrolase of the alpha beta-hydrolase fold
GO994_06040	COG0784	Response regulator, receiver
GO994_06040	COG0835	chemotaxis
GO994_06050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO994_06055	COG1047	Peptidyl-prolyl cis-trans
GO994_06060	COG2900	Belongs to the SlyX family
GO994_06070	COG0545	Peptidyl-prolyl cis-trans isomerase
GO994_06075	COG2204	response regulator
GO994_06095	COG0737	Belongs to the 5'-nucleotidase family
GO994_06100	COG2200	EAL domain
GO994_06115	COG0305	Participates in initiation and elongation during chromosome replication
GO994_06120	COG0305	Participates in initiation and elongation during chromosome replication
GO994_06125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO994_06130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO994_06140	COG2199	diguanylate cyclase activity
GO994_06140	COG2200	EAL domain
GO994_06140	COG2203	Gaf domain
GO994_06145	COG5433	transposase activity
GO994_06165	COG5433	transposase activity
GO994_06195	COG0300	oxidoreductase activity
GO994_06220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO994_06235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO994_06245	COG3813	Protein conserved in bacteria
GO994_06260	COG1280	lysine exporter protein (LysE YggA)
GO994_06270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO994_06275	COG0840	transmembrane signaling receptor activity
GO994_06290	COG0643	Histidine kinase
GO994_06290	COG2198	Histidine kinase
GO994_06300	COG0835	chemotaxis
GO994_06305	COG0840	transmembrane signaling receptor activity
GO994_06325	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO994_06330	COG2201	protein-glutamate methylesterase activity
GO994_06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO994_06385	COG2133	pyrroloquinoline quinone binding
GO994_06410	COG0077	Prephenate dehydratase
GO994_06410	COG1605	Chorismate mutase
GO994_06440	COG3272	Protein of unknown function (DUF1722)
GO994_06445	COG0789	Transcriptional regulator
GO994_06450	COG0415	Belongs to the DNA photolyase family
GO994_06460	COG0300	oxidoreductase activity
GO994_06475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO994_06500	COG0783	Belongs to the Dps family
GO994_06505	COG1151	hydroxylamine reductase activity
GO994_06515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO994_06520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO994_06520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO994_06535	COG3459	Glycosyltransferase 36 associated
GO994_06560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO994_06565	COG1666	GTP binding
GO994_06570	COG3248	Nucleoside-binding outer membrane protein
GO994_06575	COG2211	Major facilitator Superfamily
GO994_06585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO994_06595	COG2813	Specifically methylates the guanine in position
GO994_06600	COG0271	Belongs to the BolA IbaG family
GO994_06610	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO994_06615	COG1805	sodium ion transport
GO994_06620	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO994_06625	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO994_06630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO994_06635	COG2871	sodium ion transport
GO994_06640	COG1477	protein flavinylation
GO994_06655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO994_06660	COG0840	transmembrane signaling receptor activity
GO994_06665	COG0583	DNA-binding transcription factor activity
GO994_06675	COG2363	Small membrane protein
GO994_06680	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GO994_06690	COG0473	3-isopropylmalate dehydrogenase activity
GO994_06695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO994_06700	COG1611	Belongs to the LOG family
GO994_06705	COG3706	GGDEF domain
GO994_06715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO994_06715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO994_06725	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GO994_06750	COG3098	single-species biofilm formation
GO994_06755	COG0564	pseudouridine synthase activity
GO994_06765	COG4580	involved in the transport of maltose and maltodextrins
GO994_06775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO994_06775	COG1263	PTS System
GO994_06785	COG2171	N-acyltransferase activity
GO994_06790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GO994_06795	COG0024	Methionine aminopeptidase
GO994_06800	COG0052	Belongs to the universal ribosomal protein uS2 family
GO994_06805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO994_06810	COG0528	UMP kinase activity
GO994_06815	COG0233	cytoplasmic translational termination
GO994_06820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO994_06825	COG0575	Belongs to the CDS family
GO994_06830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO994_06835	COG0750	zinc metalloprotease
GO994_06850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO994_06855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO994_06860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO994_06865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO994_06870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO994_06880	COG0825	malonyl-CoA metabolic process
GO994_06885	COG3710	Transcriptional regulator
GO994_06890	COG0531	amino acid
GO994_06895	COG1982	Orn Lys Arg decarboxylase major
GO994_06900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GO994_06915	COG0814	amino acid
GO994_06920	COG0531	amino acid
GO994_06930	COG0488	(ABC) transporter
GO994_06940	COG3590	peptidase
GO994_06945	COG0037	tRNA processing
GO994_06950	COG3706	GGDEF domain
GO994_07005	COG0366	Alpha amylase catalytic
GO994_07025	COG0583	DNA-binding transcription factor activity
GO994_07035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO994_07045	COG0583	DNA-binding transcription factor activity
GO994_07050	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_07055	COG0616	signal peptide processing
GO994_07060	COG3724	N-succinylarginine dihydrolase activity
GO994_07065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO994_07075	COG0840	transmembrane signaling receptor activity
GO994_07085	COG2971	BadF BadG BcrA BcrD
GO994_07095	COG4608	Belongs to the ABC transporter superfamily
GO994_07100	COG0444	Belongs to the ABC transporter superfamily
GO994_07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO994_07155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO994_07160	COG1289	transmembrane transporter activity
GO994_07165	COG0303	'Molybdopterin
GO994_07170	COG0746	molybdenum cofactor guanylyltransferase activity
GO994_07180	COG4662	Binding-protein-dependent transport system inner membrane component
GO994_07195	COG3852	Histidine kinase
GO994_07205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO994_07210	COG3328	transposase activity
GO994_07260	COG0582	viral genome integration into host DNA
GO994_07270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO994_07280	COG2867	negative regulation of translational initiation
GO994_07290	COG0702	epimerase
GO994_07295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO994_07325	COG4964	Belongs to the GSP D family
GO994_07335	COG2894	cell division
GO994_07375	COG1454	alcohol dehydrogenase
GO994_07390	COG1957	nucleoside hydrolase
GO994_07410	COG0840	transmembrane signaling receptor activity
GO994_07415	COG1280	lysine exporter protein (LysE YggA)
GO994_07450	COG3263	regulation of cellular component size
GO994_07460	COG1876	peptidase activity
GO994_07465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO994_07470	COG1393	Belongs to the ArsC family
GO994_07475	COG0583	DNA-binding transcription factor activity
GO994_07490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO994_07495	COG0017	Asparaginyl-tRNA synthetase
GO994_07515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO994_07520	COG0156	8-amino-7-oxononanoate synthase activity
GO994_07525	COG2226	methyltransferase
GO994_07525	COG1073	alpha beta
GO994_07530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO994_07535	COG0501	Belongs to the peptidase M48B family
GO994_07545	COG0633	Ferredoxin
GO994_07545	COG3217	Mosc domain protein beta barrel domain protein
GO994_07545	COG3217	Mosc domain protein beta barrel domain protein
GO994_07545	COG0633	Ferredoxin
GO994_07575	COG2841	Protein conserved in bacteria
GO994_07585	COG0534	Mate efflux family protein
GO994_07625	COG1309	transcriptional regulator
GO994_07640	COG0791	NLP P60 protein
GO994_07655	COG0583	DNA-binding transcription factor activity
GO994_07665	COG2198	Histidine kinase
GO994_07665	COG0643	Histidine kinase
GO994_07670	COG2201	protein-glutamate methylesterase activity
GO994_07675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO994_07680	COG1360	Flagellar Motor Protein
GO994_07685	COG1192	Involved in chromosome partitioning
GO994_07695	COG0835	chemotaxis
GO994_07715	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO994_07720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO994_07725	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO994_07730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GO994_07735	COG1138	Cytochrome C-type biogenesis protein
GO994_07740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO994_07745	COG4235	cytochrome complex assembly
GO994_07745	COG3088	subunit of a heme lyase
GO994_07765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO994_07770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO994_07770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO994_07785	COG0259	pyridoxamine-phosphate oxidase activity
GO994_07800	COG3153	acetyltransferase
GO994_07825	COG2850	peptidyl-arginine hydroxylation
GO994_07830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO994_07835	COG2915	High frequency lysogenization protein hflD homolog
GO994_07840	COG0482	sulfurtransferase activity
GO994_07860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO994_07935	COG2119	membrane
GO994_07940	COG0023	Translation Initiation Factor
GO994_07990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_07990	COG2205	protein histidine kinase activity
GO994_08000	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GO994_08005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO994_08010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO994_08015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO994_08020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GO994_08025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO994_08040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO994_08045	COG0505	Belongs to the CarA family
GO994_08050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO994_08055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO994_08095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO994_08100	COG0513	Belongs to the DEAD box helicase family
GO994_08130	COG0789	Transcriptional regulator
GO994_08145	COG0493	'glutamate synthase
GO994_08150	COG0070	glutamate synthase
GO994_08150	COG0069	glutamate synthase activity
GO994_08150	COG0067	glutamate synthase
GO994_08155	COG1242	4 iron, 4 sulfur cluster binding
GO994_08200	COG5433	transposase activity
GO994_08235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO994_08240	COG1288	antiporter activity
GO994_08255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO994_08260	COG2027	D-alanyl-D-alanine carboxypeptidase
GO994_08270	COG1566	PFAM secretion protein HlyD family protein
GO994_08280	COG1966	Carbon starvation protein
GO994_08285	COG3279	Response regulator of the LytR AlgR family
GO994_08310	COG1012	belongs to the aldehyde dehydrogenase family
GO994_08310	COG1454	alcohol dehydrogenase
GO994_08320	COG2095	MarC family integral membrane protein
GO994_08330	COG0601	transmembrane transport
GO994_08335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO994_08340	COG0444	Belongs to the ABC transporter superfamily
GO994_08355	COG0861	Integral membrane protein TerC family
GO994_08375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO994_08385	COG1301	dicarboxylic acid transport
GO994_08400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO994_08415	COG0537	adenosine 5'-monophosphoramidase activity
GO994_08450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO994_08455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO994_08490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO994_08495	COG1360	Flagellar Motor Protein
GO994_08515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO994_08530	COG4597	amino acid ABC transporter
GO994_08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_08540	COG0765	amino acid transport
GO994_08565	COG0516	GMP reductase activity
GO994_08565	COG0517	IMP dehydrogenase activity
GO994_08570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO994_08570	COG0519	Catalyzes the synthesis of GMP from XMP
GO994_08590	COG5433	transposase activity
GO994_08605	COG1025	Belongs to the peptidase M16 family
GO994_08610	COG2062	phosphohistidine phosphatase, SixA
GO994_08620	COG0697	spore germination
GO994_08625	COG4166	transmembrane transport
GO994_08630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GO994_08635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO994_08645	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO994_08650	COG1136	(ABC) transporter
GO994_08655	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO994_08670	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO994_08675	COG0740	serine-type endopeptidase activity
GO994_08680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO994_08685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO994_08690	COG0776	regulation of translation
GO994_08695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO994_08700	COG0488	(ABC) transporter
GO994_08705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO994_08710	COG3162	membrane
GO994_08735	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO994_08735	COG1024	Enoyl-CoA hydratase
GO994_08740	COG1115	amino acid carrier protein
GO994_08745	COG0456	acetyltransferase
GO994_08755	COG1584	GPR1 FUN34 yaaH family protein
GO994_08775	COG5433	transposase activity
GO994_08795	COG1757	Na H antiporter
GO994_08800	COG1435	thymidine kinase activity
GO994_08820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO994_08825	COG5433	transposase activity
GO994_08840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GO994_08845	COG0437	4 iron, 4 sulfur cluster binding
GO994_08850	COG5557	Pfam Polysulphide reductase, NrfD
GO994_08855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GO994_08860	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO994_08865	COG1773	rubredoxin
GO994_08875	COG0601	transmembrane transport
GO994_08880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO994_08895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO994_08900	COG0375	protein maturation
GO994_08905	COG0309	Hydrogenase expression formation protein (HypE)
GO994_08915	COG0298	carbon dioxide binding
GO994_08920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GO994_08930	COG1921	L-seryl-tRNASec selenium transferase activity
GO994_08940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO994_08950	COG3260	NADH ubiquinone oxidoreductase 20
GO994_08955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO994_08960	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GO994_08960	COG3261	NADH dehydrogenase
GO994_08965	COG0650	Formate hydrogenlyase subunit 4
GO994_08970	COG0651	ATP synthesis coupled electron transport
GO994_08975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO994_08980	COG3158	transport of potassium into the cell
GO994_09005	COG3328	transposase activity
GO994_09060	COG1846	Transcriptional regulator
GO994_09060	COG1940	carbohydrate kinase activity
GO994_09065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO994_09070	COG0363	glucosamine-6-phosphate deaminase activity
GO994_09085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO994_09090	COG0735	belongs to the Fur family
GO994_09100	COG0716	FMN binding
GO994_09115	COG0596	Alpha beta hydrolase
GO994_09120	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GO994_09125	COG0033	Phosphoglucomutase
GO994_09135	COG1846	Transcriptional regulator
GO994_09140	COG2951	lytic endotransglycosylase activity
GO994_09145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO994_09150	COG4136	ATPase activity
GO994_09155	COG4135	transport system, permease component
GO994_09160	COG4134	Bacterial extracellular solute-binding protein
GO994_09170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO994_09180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO994_09185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO994_09200	COG0729	surface antigen
GO994_09205	COG2911	Protein conserved in bacteria
GO994_09220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO994_09245	COG1607	acyl-coa hydrolase
GO994_09255	COG3021	interspecies interaction between organisms
GO994_09260	COG0741	lytic transglycosylase activity
GO994_09260	COG1388	LysM domain
GO994_09265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO994_09270	COG2226	methyltransferase
GO994_09275	COG0328	RNA-DNA hybrid ribonuclease activity
GO994_09280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO994_09310	COG1960	acyl-CoA dehydrogenase activity
GO994_09315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO994_09320	COG0121	glutamine amidotransferase
GO994_09350	COG2197	response regulator
GO994_09355	COG3850	Histidine kinase
GO994_09360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO994_09365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO994_09375	COG0243	molybdopterin cofactor binding
GO994_09380	COG0437	4 iron, 4 sulfur cluster binding
GO994_09385	COG0348	domain, Protein
GO994_09395	COG3005	denitrification pathway
GO994_09405	COG0315	cyclic pyranopterin monophosphate synthase activity
GO994_09410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO994_09415	COG0314	molybdopterin synthase activity
GO994_09430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO994_09435	COG0596	Alpha beta hydrolase
GO994_09460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO994_09470	COG0302	gtp cyclohydrolase
GO994_09475	COG0840	transmembrane signaling receptor activity
GO994_09480	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GO994_09490	COG0583	DNA-binding transcription factor activity
GO994_09495	COG2353	YceI-like domain
GO994_09530	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO994_09540	COG1166	arginine decarboxylase activity
GO994_09555	COG0346	lactoylglutathione lyase activity
GO994_09565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO994_09570	COG1187	pseudouridine synthase activity
GO994_09575	COG2807	transmembrane transport
GO994_09585	COG0583	DNA-binding transcription factor activity
GO994_09605	COG2979	Protein of unknown function (DUF533)
GO994_09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO994_09645	COG2814	Major facilitator Superfamily
GO994_09650	COG0656	L-ascorbic acid biosynthetic process
GO994_09655	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO994_09680	COG0583	DNA-binding transcription factor activity
GO994_09685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO994_09690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO994_09695	COG2271	Major facilitator Superfamily
GO994_09700	COG1349	DNA-binding transcription factor activity
GO994_09710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO994_09715	COG0584	glycerophosphoryl diester phosphodiesterase
GO994_09720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO994_09725	COG1605	Chorismate mutase
GO994_09725	COG0287	Prephenate dehydrogenase
GO994_09730	COG0583	DNA-binding transcription factor activity
GO994_09735	COG3085	chromosome segregation
GO994_09740	COG4574	serine-type endopeptidase inhibitor activity
GO994_09760	COG1770	oligopeptidase
GO994_09765	COG4771	TonB-dependent receptor
GO994_09770	COG3083	sulfuric ester hydrolase activity
GO994_09775	COG3082	Protein of unknown function (DUF1414)
GO994_09780	COG3081	Nucleoid-associated protein
GO994_09790	COG2182	Extracellular solute-binding protein
GO994_09795	COG1175	transmembrane transport
GO994_09805	COG3842	ATPase activity
GO994_09820	COG0628	permease
GO994_09825	COG0425	Belongs to the sulfur carrier protein TusA family
GO994_09830	COG4783	chaperone-mediated protein folding
GO994_09840	COG1393	Belongs to the ArsC family
GO994_09850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GO994_09855	COG2431	L-lysine efflux transmembrane transporter activity
GO994_09870	COG4215	(ABC) transporter
GO994_09890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO994_09900	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO994_09905	COG2373	Large extracellular alpha-helical protein
GO994_09910	COG4953	penicillin-binding protein 1C
GO994_09920	COG0301	tRNA thio-modification
GO994_09920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO994_09950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO994_09965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO994_09975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO994_09995	COG0483	inositol monophosphate 1-phosphatase activity
GO994_10020	COG0625	glutathione transferase activity
GO994_10030	COG0601	transmembrane transport
GO994_10035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO994_10040	COG0444	Belongs to the ABC transporter superfamily
GO994_10045	COG2814	Major facilitator Superfamily
GO994_10050	COG0583	DNA-binding transcription factor activity
GO994_10055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO994_10060	COG0243	molybdopterin cofactor binding
GO994_10080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO994_10085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO994_10090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO994_10095	COG0509	glycine decarboxylation via glycine cleavage system
GO994_10100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO994_10100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO994_10115	COG3634	alkyl hydroperoxide reductase activity
GO994_10120	COG0450	alkyl hydroperoxide reductase
GO994_10125	COG0517	IMP dehydrogenase activity
GO994_10130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO994_10135	COG0343	queuine tRNA-ribosyltransferase activity
GO994_10140	COG1862	Preprotein translocase
GO994_10145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO994_10150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO994_10155	COG2897	thiosulfate sulfurtransferase activity
GO994_10190	COG1959	2 iron, 2 sulfur cluster binding
GO994_10195	COG1104	cysteine desulfurase activity
GO994_10200	COG0822	iron-sulfur transferase activity
GO994_10210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO994_10215	COG0443	Heat shock 70 kDa protein
GO994_10220	COG0633	Ferredoxin
GO994_10230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO994_10235	COG0105	UTP biosynthetic process
GO994_10240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO994_10250	COG1426	Protein conserved in bacteria
GO994_10255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO994_10260	COG0124	histidyl-tRNA synthetase
GO994_10265	COG2976	Protein conserved in bacteria
GO994_10270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO994_10275	COG1160	GTP binding
GO994_10280	COG1645	bacterial-type flagellum-dependent swarming motility
GO994_10285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO994_10290	COG0047	phosphoribosylformylglycinamidine synthase activity
GO994_10290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO994_10300	COG2354	Protein conserved in bacteria
GO994_10320	COG5433	transposase activity
GO994_10350	COG1024	Enoyl-CoA hydratase
GO994_10355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO994_10360	COG1960	acyl-CoA dehydrogenase activity
GO994_10375	COG1024	Enoyl-CoA hydratase
GO994_10380	COG1024	Enoyl-CoA hydratase
GO994_10390	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_10400	COG0730	response to heat
GO994_10420	COG3328	transposase activity
GO994_10440	COG1609	Transcriptional regulator
GO994_10445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_10445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_10450	COG1105	Belongs to the carbohydrate kinase PfkB family
GO994_10455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO994_10455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO994_10455	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GO994_10460	COG3313	Fe-S protein
GO994_10465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GO994_10470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO994_10475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO994_10480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO994_10490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO994_10510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO994_10515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO994_10520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO994_10525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO994_10530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO994_10535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO994_10535	COG0072	phenylalanine-tRNA ligase activity
GO994_10540	COG0776	regulation of translation
GO994_10560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO994_10570	COG5001	Diguanylate cyclase
GO994_10570	COG3300	MHYT domain
GO994_10575	COG1609	Transcriptional regulator
GO994_10580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO994_10585	COG1879	ABC-type sugar transport system periplasmic component
GO994_10590	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO994_10595	COG1129	ABC transporter
GO994_10600	COG1869	D-ribose catabolic process
GO994_10605	COG0625	glutathione transferase activity
GO994_10620	COG0037	tRNA processing
GO994_10625	COG0589	response to stress
GO994_10630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO994_10645	COG2217	Heavy metal translocating P-type atpase
GO994_10655	COG2010	Cytochrome c
GO994_10670	COG3278	Belongs to the heme-copper respiratory oxidase family
GO994_10680	COG1956	GAF domain-containing protein
GO994_10685	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GO994_10695	COG0308	aminopeptidase N
GO994_10720	COG0167	dihydroorotate dehydrogenase activity
GO994_10740	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GO994_10745	COG1874	Beta-galactosidase
GO994_10760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO994_10765	COG0254	rRNA binding
GO994_10780	COG1451	nucleotide metabolic process
GO994_10795	COG3069	C4-dicarboxylate transmembrane transporter activity
GO994_10805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO994_10805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO994_10810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO994_10830	COG2009	succinate dehydrogenase
GO994_10835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO994_10840	COG1053	succinate dehydrogenase
GO994_10850	COG0567	Dehydrogenase, E1 component
GO994_10855	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO994_10860	COG0045	succinate-CoA ligase (ADP-forming) activity
GO994_10865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO994_10875	COG1882	Formate acetyltransferase
GO994_10880	COG2116	formate transmembrane transporter activity
GO994_10885	COG1944	ATP diphosphatase activity
GO994_10890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO994_10910	COG5433	transposase activity
GO994_10950	COG4681	YaeQ
GO994_10970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO994_10990	COG3134	Outer membrane lipoprotein
GO994_11000	COG1288	antiporter activity
GO994_11035	COG0058	SHG alpha-glucan phosphorylase activity
GO994_11040	COG0471	metal ion transport
GO994_11045	COG3118	belongs to the thioredoxin family
GO994_11060	COG1132	(ABC) transporter
GO994_11070	COG2501	S4 domain
GO994_11080	COG3243	poly(R)-hydroxyalkanoic acid synthase
GO994_11100	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GO994_11105	COG2329	Antibiotic biosynthesis monooxygenase
GO994_11155	COG1742	UPF0060 membrane protein
GO994_11170	COG0513	Belongs to the DEAD box helicase family
GO994_11175	COG0386	Belongs to the glutathione peroxidase family
GO994_11185	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO994_11200	COG0730	response to heat
GO994_11205	COG0583	DNA-binding transcription factor activity
GO994_11220	COG3593	DNA synthesis involved in DNA repair
GO994_11280	COG1011	Hydrolase
GO994_11295	COG5433	transposase activity
GO994_11390	COG2840	Smr protein MutS2
GO994_11395	COG2890	protein-(glutamine-N5) methyltransferase activity
GO994_11400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO994_11410	COG0513	Belongs to the DEAD box helicase family
GO994_11415	COG5654	RES domain protein
GO994_11445	COG1067	ATP-dependent peptidase activity
GO994_11450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO994_11475	COG0116	Belongs to the methyltransferase superfamily
GO994_11475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO994_11490	COG3620	sequence-specific DNA binding
GO994_11520	COG4221	oxidoreductase activity
GO994_11565	COG0372	Belongs to the citrate synthase family
GO994_11570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO994_11580	COG2995	paraquat-inducible protein a
GO994_11585	COG3008	intermembrane lipid transfer
GO994_11590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GO994_11590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO994_11605	COG0084	hydrolase, TatD family'
GO994_11610	COG0470	DNA polymerase III
GO994_11615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO994_11620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO994_11625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO994_11630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO994_11635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO994_11640	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_11650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO994_11655	COG0416	fatty acid biosynthetic process
GO994_11660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GO994_11665	COG1399	metal-binding, possibly nucleic acid-binding protein
GO994_11670	COG0424	maF-like protein
GO994_11685	COG1530	ribonuclease E activity
GO994_11695	COG0717	Belongs to the dCTP deaminase family
GO994_11700	COG0572	uridine kinase
GO994_11705	COG0489	protein tyrosine kinase activity
GO994_11710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO994_11710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO994_11715	COG0625	glutathione transferase activity
GO994_11720	COG1254	Belongs to the acylphosphatase family
GO994_11740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO994_11755	COG0709	Synthesizes selenophosphate from selenide and ATP
GO994_11760	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GO994_11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO994_11770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO994_11780	COG1643	Atp-dependent helicase
GO994_11790	COG2197	response regulator
GO994_11800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO994_11805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO994_11810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO994_11815	COG2832	Protein of unknown function (DUF454)
GO994_11820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO994_11840	COG0318	PFAM AMP-dependent synthetase and ligase
GO994_11845	COG2267	carboxylic ester hydrolase activity
GO994_11855	COG1214	PFAM Peptidase M22, glycoprotease
GO994_11860	COG1199	ATP-dependent helicase activity
GO994_11870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO994_11875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO994_11880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO994_11885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO994_11885	COG0131	Imidazoleglycerol-phosphate dehydratase
GO994_11890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO994_11895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO994_11900	COG3437	response regulator, receiver
GO994_11910	COG2205	protein histidine kinase activity
GO994_11910	COG0784	Response regulator, receiver
GO994_11910	COG2198	Histidine kinase
GO994_11915	COG0107	imidazoleglycerol-phosphate synthase activity
GO994_11920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO994_11920	COG0140	phosphoribosyl-ATP diphosphatase activity
GO994_11930	COG2378	regulation of single-species biofilm formation
GO994_11970	COG0814	amino acid
GO994_11975	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GO994_11980	COG0514	ATP-dependent DNA helicase (RecQ)
GO994_11985	COG2766	serine protein kinase
GO994_11995	COG2719	SpoVR family
GO994_12000	COG2186	Transcriptional regulator
GO994_12005	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO994_12010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO994_12015	COG0586	Pfam SNARE associated Golgi protein
GO994_12025	COG0556	nucleotide-excision repair
GO994_12035	COG2985	domain, Protein
GO994_12035	COG0569	domain protein
GO994_12040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO994_12060	COG4565	transcriptional regulatory protein
GO994_12070	COG1846	Transcriptional regulator
GO994_12070	COG1940	carbohydrate kinase activity
GO994_12075	COG0840	transmembrane signaling receptor activity
GO994_12080	COG3012	SEC-C Motif Domain Protein
GO994_12085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO994_12090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GO994_12095	COG0247	lactate metabolic process
GO994_12105	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GO994_12110	COG0437	4 iron, 4 sulfur cluster binding
GO994_12115	COG3301	Polysulphide reductase, NrfD
GO994_12130	COG3088	subunit of a heme lyase
GO994_12130	COG4235	cytochrome complex assembly
GO994_12145	COG3033	Beta-eliminating lyase
GO994_12160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO994_12195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO994_12210	COG4774	siderophore transport
GO994_12215	COG2207	Transcriptional regulator
GO994_12215	COG3708	Transcriptional regulator
GO994_12225	COG0583	DNA-binding transcription factor activity
GO994_12280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO994_12285	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO994_12290	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GO994_12300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO994_12305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GO994_12315	COG0205	6-phosphofructokinase activity
GO994_12385	COG2824	Alkylphosphonate utilization operon protein PhnA
GO994_12390	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO994_12390	COG1024	Enoyl-CoA hydratase
GO994_12395	COG0183	Belongs to the thiolase family
GO994_12400	COG0714	Associated with various cellular activities
GO994_12440	COG2067	long-chain fatty acid transport protein
GO994_12445	COG2067	long-chain fatty acid transport protein
GO994_12450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO994_12470	COG3123	guanosine phosphorylase activity
GO994_12475	COG1760	l-serine dehydratase
GO994_12480	COG1760	l-serine dehydratase
GO994_12485	COG2951	lytic endotransglycosylase activity
GO994_12490	COG3100	YcgL domain-containing protein
GO994_12495	COG0850	regulation of cytokinetic process
GO994_12500	COG2894	cell division
GO994_12505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GO994_12515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO994_12555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO994_12560	COG0697	spore germination
GO994_12565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO994_12570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO994_12580	COG0307	riboflavin synthase, alpha
GO994_12590	COG0534	Mate efflux family protein
GO994_12625	COG0417	DNA replication proofreading
GO994_12635	COG2203	Gaf domain
GO994_12635	COG2199	diguanylate cyclase activity
GO994_12650	COG1560	Kdo2-lipid A biosynthetic process
GO994_12655	COG1560	Kdo2-lipid A biosynthetic process
GO994_12665	COG0583	DNA-binding transcription factor activity
GO994_12670	COG0673	inositol 2-dehydrogenase activity
GO994_12675	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO994_12680	COG0583	DNA-binding transcription factor activity
GO994_12690	COG2723	6-phospho-beta-galactosidase activity
GO994_12695	COG0583	DNA-binding transcription factor activity
GO994_12700	COG5433	transposase activity
GO994_12765	COG4580	involved in the transport of maltose and maltodextrins
GO994_12770	COG1609	Transcriptional regulator
GO994_12775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO994_12785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO994_12795	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO994_12800	COG1129	ABC transporter
GO994_12805	COG1879	ABC-type sugar transport system periplasmic component
GO994_12810	COG1069	ribulokinase activity
GO994_12820	COG2160	L-arabinose isomerase activity
GO994_12825	COG0583	DNA-binding transcription factor activity
GO994_12830	COG0436	Aminotransferase
GO994_12835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO994_12850	COG2925	Exonuclease
GO994_12860	COG3345	alpha-galactosidase
GO994_12865	COG1380	Effector of murein hydrolase LrgA
GO994_12870	COG1346	cytolysis
GO994_12875	COG0295	cytidine deaminase activity
GO994_12880	COG1022	Amp-dependent synthetase and ligase
GO994_12895	COG0861	Integral membrane protein TerC family
GO994_12905	COG2199	diguanylate cyclase activity
GO994_12920	COG2154	pterin-4-alpha-carbinolamine dehydratase
GO994_12930	COG3768	UPF0283 membrane protein
GO994_12935	COG3106	COG3106 Predicted ATPase
GO994_12950	COG1842	Phage shock protein A
GO994_12955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO994_12965	COG4168	peptide transport system, permease
GO994_12970	COG4171	peptide transport system, permease
GO994_12975	COG4172	Belongs to the ABC transporter superfamily
GO994_12980	COG4172	Belongs to the ABC transporter superfamily
GO994_12990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO994_12995	COG1286	toxin biosynthetic process
GO994_13000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO994_13005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO994_13010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO994_13015	COG1674	ftsk spoiiie
GO994_13015	COG0531	amino acid
GO994_13035	COG0492	ferredoxin-NADP+ reductase activity
GO994_13045	COG3134	Outer membrane lipoprotein
GO994_13050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO994_13055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GO994_13060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO994_13065	COG0542	response to heat
GO994_13070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO994_13075	COG1278	Cold shock
GO994_13080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO994_13195	COG0659	secondary active sulfate transmembrane transporter activity
GO994_13225	COG0697	spore germination
GO994_13230	COG4657	Part of a membrane complex involved in electron transport
GO994_13235	COG2878	Part of a membrane complex involved in electron transport
GO994_13245	COG4658	electron transport chain
GO994_13250	COG4659	FMN binding
GO994_13260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO994_13265	COG0346	lactoylglutathione lyase activity
GO994_13280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO994_13285	COG2056	Na+-H+ antiporter family
GO994_13290	COG3328	transposase activity
GO994_13305	COG0513	Belongs to the DEAD box helicase family
GO994_13310	COG2050	protein possibly involved in aromatic compounds catabolism
GO994_13320	COG0247	lactate metabolic process
GO994_13320	COG0277	FAD linked oxidase domain protein
GO994_13330	COG1253	flavin adenine dinucleotide binding
GO994_13335	COG1902	pentaerythritol trinitrate reductase activity
GO994_13340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO994_13345	COG0647	UMP catabolic process
GO994_13350	COG4651	solute:proton antiporter activity
GO994_13350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO994_13360	COG0367	asparagine synthase
GO994_13385	COG0625	glutathione transferase activity
GO994_13390	COG0625	glutathione transferase activity
GO994_13415	COG0564	pseudouridine synthase activity
GO994_13435	COG0840	transmembrane signaling receptor activity
GO994_13445	COG0670	Belongs to the BI1 family
GO994_13450	COG1289	transmembrane transporter activity
GO994_13455	COG2920	part of a sulfur-relay system
GO994_13460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GO994_13465	COG0285	dihydrofolate synthase activity
GO994_13470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO994_13475	COG0101	tRNA pseudouridine synthase activity
GO994_13485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO994_13490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO994_13495	COG0671	phosphoesterase, PA-phosphatase related
GO994_13575	COG0574	Belongs to the PEP-utilizing enzyme family
GO994_13575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO994_13580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO994_13620	COG0672	)-iron permease
GO994_13645	COG2814	Major facilitator Superfamily
GO994_13660	COG1136	(ABC) transporter
GO994_13680	COG1285	pathogenesis
GO994_13735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO994_13740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO994_13740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO994_13755	COG1368	sulfuric ester hydrolase activity
GO994_13780	COG0393	Putative heavy-metal-binding
GO994_13785	COG1252	NADH dehydrogenase
GO994_13815	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO994_13820	COG2096	Adenosyltransferase
GO994_13825	COG3530	Putative quorum-sensing-regulated virulence factor
GO994_13830	COG0602	queuosine metabolic process
GO994_13835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO994_13850	COG0284	orotidine-5'-phosphate decarboxylase activity
GO994_13855	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GO994_13865	COG0776	regulation of translation
GO994_13870	COG0539	negative regulation of cytoplasmic translation
GO994_13875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO994_13880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO994_13890	COG0583	DNA-binding transcription factor activity
GO994_13895	COG2814	Major facilitator Superfamily
GO994_13915	COG3300	MHYT domain
GO994_13915	COG5001	Diguanylate cyclase
GO994_13930	COG0583	DNA-binding transcription factor activity
GO994_13960	COG4989	oxidoreductase activity
GO994_13965	COG0724	RNA recognition motif
GO994_13990	COG1570	exodeoxyribonuclease VII activity
GO994_14005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO994_14010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO994_14015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO994_14035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GO994_14035	COG0644	oxidoreductase
GO994_14040	COG0598	Magnesium transport protein CorA
GO994_14060	COG4771	TonB-dependent receptor
GO994_14065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO994_14070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO994_14075	COG1120	ATPase activity
GO994_14080	COG2977	Belongs to the P-Pant transferase superfamily
GO994_14085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO994_14090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO994_14090	COG0300	oxidoreductase activity
GO994_14090	COG0318	PFAM AMP-dependent synthetase and ligase
GO994_14090	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_14090	COG3321	synthase
GO994_14100	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_14110	COG1535	isochorismatase
GO994_14110	COG3433	isochorismatase activity
GO994_14115	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO994_14140	COG3300	MHYT domain
GO994_14140	COG5001	Diguanylate cyclase
GO994_14155	COG0840	transmembrane signaling receptor activity
GO994_14160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO994_14165	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GO994_14170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO994_14175	COG0563	adenylate kinase activity
GO994_14185	COG0326	Molecular chaperone. Has ATPase activity
GO994_14190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO994_14210	COG5433	transposase activity
GO994_14235	COG5433	transposase activity
GO994_14240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO994_14240	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_14240	COG3321	synthase
GO994_14240	COG4221	oxidoreductase activity
GO994_14255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO994_14275	COG0217	transcriptional regulatory protein
GO994_14280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO994_14300	COG4106	trans-aconitate 2-methyltransferase activity
GO994_14305	COG0500	methyltransferase
GO994_14325	COG0450	alkyl hydroperoxide reductase
GO994_14330	COG5433	transposase activity
GO994_14340	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GO994_14355	COG0455	bacterial-type flagellum organization
GO994_14365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO994_14375	COG1684	flagellar biosynthetic protein fliR
GO994_14380	COG1987	bacterial-type flagellum assembly
GO994_14430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO994_14440	COG1677	Flagellar hook-basal body complex protein FliE
GO994_14450	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GO994_14465	COG1342	Belongs to the UPF0251 family
GO994_14485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO994_14500	COG3290	protein histidine kinase activity
GO994_14510	COG1737	Transcriptional regulator
GO994_14515	COG0469	pyruvate kinase activity
GO994_14525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO994_14530	COG1960	acyl-CoA dehydrogenase activity
GO994_14545	COG5433	transposase activity
GO994_14555	COG5433	transposase activity
GO994_14580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO994_14590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO994_14595	COG2261	transglycosylase associated protein
GO994_14635	COG0322	excinuclease ABC activity
GO994_14640	COG2197	response regulator
GO994_14645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GO994_14650	COG2835	tetraacyldisaccharide 4'-kinase activity
GO994_14655	COG1663	tetraacyldisaccharide 4'-kinase activity
GO994_14660	COG1132	(ABC) transporter
GO994_14665	COG0658	competence protein
GO994_14665	COG2333	competence protein COMEC
GO994_14680	COG0433	COG0433 Predicted ATPase
GO994_14685	COG1448	Aminotransferase
GO994_14700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO994_14705	COG1199	ATP-dependent helicase activity
GO994_14715	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO994_14720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO994_14725	COG1785	Belongs to the alkaline phosphatase family
GO994_14745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO994_14760	COG2271	Major facilitator Superfamily
GO994_14765	COG3706	GGDEF domain
GO994_14770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_14775	COG0765	amino acid transport
GO994_14780	COG1126	abc transporter atp-binding protein
GO994_14790	COG0531	amino acid
GO994_14805	COG1253	flavin adenine dinucleotide binding
GO994_14810	COG0704	Plays a role in the regulation of phosphate uptake
GO994_14820	COG0581	inorganic phosphate transmembrane transporter activity
GO994_14825	COG0573	inorganic phosphate transmembrane transporter activity
GO994_14830	COG0590	tRNA wobble adenosine to inosine editing
GO994_14840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO994_14860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO994_14865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO994_14870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO994_14875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO994_14880	COG2204	response regulator
GO994_14885	COG3852	Histidine kinase
GO994_14890	COG2204	response regulator
GO994_14905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO994_14910	COG0248	Ppx GppA phosphatase
GO994_14915	COG2239	Acts as a magnesium transporter
GO994_14955	COG0622	Phosphoesterase
GO994_14960	COG4166	transmembrane transport
GO994_14970	COG1187	pseudouridine synthase activity
GO994_14990	COG0697	spore germination
GO994_15020	COG1278	Cold shock
GO994_15075	COG3132	Protein of unknown function, DUF480
GO994_15085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO994_15115	COG0583	DNA-binding transcription factor activity
GO994_15120	COG2610	gluconate transmembrane transporter activity
GO994_15125	COG3048	D-serine ammonia-lyase activity
GO994_15135	COG0538	isocitrate dehydrogenase activity
GO994_15140	COG2207	Transcriptional regulator
GO994_15155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO994_15185	COG5433	transposase activity
GO994_15215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_15220	COG3706	GGDEF domain
GO994_15225	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO994_15230	COG0733	neurotransmitter:sodium symporter activity
GO994_15255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GO994_15255	COG2885	chlorophyll binding
GO994_15260	COG0281	malic enzyme
GO994_15265	COG2207	Transcriptional regulator
GO994_15280	COG3706	GGDEF domain
GO994_15280	COG0745	RESPONSE REGULATOR receiver
GO994_15285	COG2233	PERMEase
GO994_15290	COG0095	Lipoate-protein ligase
GO994_15295	COG1115	amino acid carrier protein
GO994_15300	COG0019	diaminopimelate decarboxylase activity
GO994_15320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GO994_15340	COG1131	(ABC) transporter
GO994_15345	COG0545	Peptidyl-prolyl cis-trans isomerase
GO994_15350	COG3142	Participates in the control of copper homeostasis
GO994_15355	COG1940	carbohydrate kinase activity
GO994_15365	COG4783	chaperone-mediated protein folding
GO994_15375	COG5002	protein histidine kinase activity
GO994_15380	COG0745	RESPONSE REGULATOR receiver
GO994_15385	COG0346	lactoylglutathione lyase activity
GO994_15390	COG3706	GGDEF domain
GO994_15395	COG3284	Transcriptional regulator
GO994_15400	COG1012	belongs to the aldehyde dehydrogenase family
GO994_15405	COG1942	4-Oxalocrotonate Tautomerase
GO994_15410	COG2267	carboxylic ester hydrolase activity
GO994_15430	COG0697	spore germination
GO994_15440	COG0667	Aldo Keto reductase
GO994_15455	COG3290	protein histidine kinase activity
GO994_15460	COG0281	malic enzyme
GO994_15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_15540	COG0281	malic enzyme
GO994_15555	COG0437	4 iron, 4 sulfur cluster binding
GO994_15560	COG3383	formate dehydrogenase (NAD+) activity
GO994_15605	COG5433	transposase activity
GO994_15625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO994_15670	COG3273	potassium ion transport
GO994_15670	COG0471	metal ion transport
GO994_15690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO994_15695	COG0438	transferase activity, transferring glycosyl groups
GO994_15715	COG1450	Type ii and iii secretion system protein
GO994_15755	COG1459	type II secretion system
GO994_15760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO994_15780	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO994_15790	COG1538	Outer membrane efflux protein
GO994_15800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_15805	COG1309	transcriptional regulator
GO994_15820	COG1946	Acyl-CoA thioesterase
GO994_15830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO994_15840	COG0009	L-threonylcarbamoyladenylate synthase
GO994_15845	COG0613	PHP domain protein
GO994_15855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO994_15860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO994_15860	COG0512	Glutamine amidotransferase of anthranilate synthase
GO994_15865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO994_15870	COG0134	indole-3-glycerol-phosphate synthase activity
GO994_15870	COG0135	phosphoribosylanthranilate isomerase activity
GO994_15875	COG0133	tryptophan synthase activity
GO994_15905	COG1376	ErfK ybiS ycfS ynhG family protein
GO994_15905	COG1388	LysM domain
GO994_15920	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GO994_15925	COG0791	NLP P60 protein
GO994_15930	COG2091	lysine biosynthetic process via aminoadipic acid
GO994_15935	COG3118	belongs to the thioredoxin family
GO994_15945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO994_15950	COG0788	formyltetrahydrofolate deformylase activity
GO994_15980	COG0366	Alpha amylase catalytic
GO994_15985	COG0739	heme binding
GO994_15985	COG0741	lytic transglycosylase activity
GO994_15985	COG1196	nuclear chromosome segregation
GO994_15990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO994_15995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO994_16000	COG0673	inositol 2-dehydrogenase activity
GO994_16030	COG2814	Major facilitator Superfamily
GO994_16035	COG0109	protoheme IX farnesyltransferase activity
GO994_16045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO994_16050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO994_16115	COG0708	Exodeoxyribonuclease III
GO994_16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_16145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO994_16155	COG0095	Lipoate-protein ligase
GO994_16185	COG0640	Transcriptional regulator
GO994_16200	COG1285	pathogenesis
GO994_16230	COG0484	heat shock protein binding
GO994_16235	COG0443	Heat shock 70 kDa protein
GO994_16240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO994_16245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO994_16250	COG0497	DNA recombination
GO994_16255	COG1227	inorganic diphosphatase activity
GO994_16265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO994_16270	COG0577	efflux transmembrane transporter activity
GO994_16270	COG1136	(ABC) transporter
GO994_16275	COG1538	Outer membrane efflux protein
GO994_16280	COG2375	cellular response to nickel ion
GO994_16285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO994_16295	COG3328	transposase activity
GO994_16300	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO994_16335	COG2169	Transcriptional regulator
GO994_16335	COG1917	Cupin 2, conserved barrel domain protein
GO994_16355	COG1917	Cupin 2, conserved barrel domain protein
GO994_16355	COG1396	sequence-specific DNA binding
GO994_16370	COG0531	amino acid
GO994_16375	COG0531	amino acid
GO994_16380	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO994_16390	COG3384	dioxygenase
GO994_16405	COG0813	purine-nucleoside phosphorylase activity
GO994_16430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO994_16435	COG0083	homoserine kinase activity
GO994_16450	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO994_16455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GO994_16470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO994_16480	COG0745	RESPONSE REGULATOR receiver
GO994_16495	COG4988	ABC transporter
GO994_16500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO994_16520	COG1720	tRNA m6t6A37 methyltransferase activity
GO994_16540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO994_16545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO994_16555	COG2190	(PTS) system
GO994_16560	COG3706	GGDEF domain
GO994_16570	COG3038	cytochrome b561
GO994_16580	COG0419	ATPase involved in DNA repair
GO994_16585	COG0420	3'-5' exonuclease activity
GO994_16595	COG2974	May be involved in recombination
GO994_16605	COG4651	solute:proton antiporter activity
GO994_16605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO994_16610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO994_16610	COG4651	solute:proton antiporter activity
GO994_16625	COG0469	pyruvate kinase activity
GO994_16630	COG3264	Mechanosensitive ion channel
GO994_16630	COG1196	nuclear chromosome segregation
GO994_16635	COG0582	viral genome integration into host DNA
GO994_16660	COG1846	Transcriptional regulator
GO994_16665	COG1566	PFAM secretion protein HlyD family protein
GO994_16690	COG0602	queuosine metabolic process
GO994_16700	COG1328	CTP reductase activity
GO994_16710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO994_16715	COG3115	cell septum assembly
GO994_16720	COG1196	nuclear chromosome segregation
GO994_16730	COG2860	membrane
GO994_16740	COG3108	Peptidase M15
GO994_16745	COG2989	Protein conserved in bacteria
GO994_16755	COG5433	transposase activity
GO994_16765	COG0463	Glycosyl transferase, family 2
GO994_16780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO994_16785	COG0739	heme binding
GO994_16790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO994_16795	COG5433	transposase activity
GO994_16825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO994_16835	COG3091	SprT-like family
GO994_16845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO994_16850	COG0189	ligase activity
GO994_16865	COG1678	Uncharacterized ACR, COG1678
GO994_16870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO994_16875	COG0583	DNA-binding transcription factor activity
GO994_16900	COG0714	Associated with various cellular activities
GO994_16915	COG1115	amino acid carrier protein
GO994_16920	COG5433	transposase activity
GO994_16925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO994_16940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO994_16960	COG1301	dicarboxylic acid transport
GO994_16970	COG2912	Transglutaminase-like superfamily
GO994_16980	COG2890	protein-(glutamine-N5) methyltransferase activity
GO994_16985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO994_16990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO994_16995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO994_17000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO994_17010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO994_17015	COG0737	Belongs to the 5'-nucleotidase family
GO994_17020	COG0193	aminoacyl-tRNA hydrolase activity
GO994_17025	COG0012	GTP binding
GO994_17070	COG0471	metal ion transport
GO994_17070	COG0490	domain, Protein
GO994_17080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GO994_17115	COG0463	Glycosyl transferase, family 2
GO994_17130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO994_17135	COG2076	Multidrug Resistance protein
GO994_17140	COG2076	Multidrug Resistance protein
GO994_17145	COG3954	Phosphoribulokinase
GO994_17160	COG1765	OsmC-like protein
GO994_17165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO994_17175	COG3397	chitin binding
GO994_17190	COG2202	Pas domain
GO994_17190	COG2205	protein histidine kinase activity
GO994_17200	COG3655	Transcriptional regulator
GO994_17210	COG2814	Major facilitator Superfamily
GO994_17215	COG4771	TonB-dependent receptor
GO994_17235	COG0748	coenzyme F420 binding
GO994_17240	COG3721	Heme iron utilization protein
GO994_17250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO994_17275	COG0488	(ABC) transporter
GO994_17285	COG2252	PERMEase
GO994_17290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO994_17295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO994_17300	COG3178	'Phosphotransferase
GO994_17305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GO994_17315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GO994_17320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO994_17330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO994_17345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO994_17365	COG0318	PFAM AMP-dependent synthetase and ligase
GO994_17375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO994_17380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO994_17385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO994_17390	COG0142	geranyltranstransferase activity
GO994_17395	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GO994_17400	COG0330	HflC and HflK could
GO994_17405	COG0330	HflC and HflK could
GO994_17410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO994_17415	COG1923	regulation of RNA biosynthetic process
GO994_17420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO994_17425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO994_17435	COG0802	atpase or kinase
GO994_17440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO994_17440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GO994_17460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO994_17465	COG2011	ABC-type metal ion transport system permease component
GO994_17470	COG1464	Belongs to the NlpA lipoprotein family
GO994_17505	COG5002	protein histidine kinase activity
GO994_17505	COG0784	Response regulator, receiver
GO994_17505	COG2198	Histidine kinase
GO994_17540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO994_17545	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GO994_17555	COG2716	regulation of RNA biosynthetic process
GO994_17560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO994_17565	COG3013	Belongs to the UPF0304 family
GO994_17570	COG3092	negative regulation of chromosome organization
GO994_17575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO994_17580	COG0857	belongs to the CobB CobQ family
GO994_17580	COG0280	phosphate acetyltransferase
GO994_17585	COG0440	acetolactate synthase activity
GO994_17590	COG0028	Belongs to the TPP enzyme family
GO994_17605	COG0671	phosphoesterase, PA-phosphatase related
GO994_17615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO994_17620	COG0473	3-isopropylmalate dehydrogenase activity
GO994_17625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO994_17630	COG0066	3-isopropylmalate dehydratase activity
GO994_17645	COG4143	(ABC) transporter
GO994_17650	COG1178	ABC-type Fe3 transport system permease component
GO994_17655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO994_17660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO994_17670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO994_17700	COG0316	Belongs to the HesB IscA family
GO994_17710	COG0038	chloride channel
GO994_17715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO994_17730	COG0671	phosphoesterase, PA-phosphatase related
GO994_17740	COG0784	Response regulator, receiver
GO994_17740	COG3437	response regulator, receiver
GO994_17745	COG0583	DNA-binding transcription factor activity
GO994_17750	COG2076	Multidrug Resistance protein
GO994_17760	COG0346	lactoylglutathione lyase activity
GO994_17765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO994_17770	COG1643	Atp-dependent helicase
GO994_17780	COG1489	DNA binding
GO994_17785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO994_17790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO994_17795	COG0617	tRNA 3'-terminal CCA addition
GO994_17800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO994_17805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO994_17810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO994_17820	COG0842	Transport permease protein
GO994_17825	COG1131	(ABC) transporter
GO994_17840	COG0163	prenyltransferase activity
GO994_17845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO994_17850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO994_17855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO994_17860	COG2816	NAD+ diphosphatase activity
GO994_17865	COG0506	proline dehydrogenase activity
GO994_17865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO994_17865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO994_17870	COG4991	sh3 domain protein
GO994_17875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO994_17895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO994_17900	COG1640	4-alpha-glucanotransferase
GO994_17905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO994_17910	COG0676	glucose-6-phosphate 1-epimerase activity
GO994_17915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO994_17920	COG0840	transmembrane signaling receptor activity
GO994_17985	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GO994_17990	COG2885	chlorophyll binding
GO994_17995	COG0823	Involved in the tonB-independent uptake of proteins
GO994_18010	COG0811	peptide transport
GO994_18015	COG0824	Thioesterase
GO994_18020	COG3790	cyd operon protein YbgE
GO994_18025	COG4890	Cyd operon protein YbgT
GO994_18030	COG1294	oxidase, subunit
GO994_18035	COG1271	oxidase subunit
GO994_18040	COG2255	four-way junction helicase activity
GO994_18045	COG0632	four-way junction helicase activity
GO994_18050	COG0840	transmembrane signaling receptor activity
GO994_18055	COG0442	prolyl-tRNA aminoacylation
GO994_18065	COG1902	pentaerythritol trinitrate reductase activity
GO994_18075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO994_18080	COG0745	RESPONSE REGULATOR receiver
GO994_18080	COG3706	GGDEF domain
GO994_18105	COG0714	Associated with various cellular activities
GO994_18115	COG0456	acetyltransferase
GO994_18125	COG1022	Amp-dependent synthetase and ligase
GO994_18135	COG2918	glutathione biosynthetic process
GO994_18140	COG0612	Peptidase, M16
GO994_18145	COG1238	metal cluster binding
GO994_18150	COG1064	alcohol dehydrogenase
GO994_18180	COG0359	binds to the 23S rRNA
GO994_18185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO994_18190	COG0360	Binds together with S18 to 16S ribosomal RNA
GO994_18195	COG1914	H( )-stimulated, divalent metal cation uptake system
GO994_18200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO994_18215	COG2153	protein acetylation
GO994_18225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO994_18230	COG0557	exoribonuclease II activity
GO994_18235	COG3706	GGDEF domain
GO994_18240	COG1854	S-ribosylhomocysteine lyase activity
GO994_18255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO994_18255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO994_18290	COG4968	Prepilin-type N-terminal cleavage methylation domain
GO994_18295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO994_18300	COG1047	Peptidyl-prolyl cis-trans
GO994_18305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO994_18310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO994_18315	COG0196	riboflavin kinase activity
GO994_18320	COG0728	peptidoglycan biosynthetic process
GO994_18325	COG0268	Binds directly to 16S ribosomal RNA
GO994_18330	COG0640	Transcriptional regulator
GO994_18335	COG0583	DNA-binding transcription factor activity
GO994_18345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO994_18350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO994_18355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO994_18375	COG1051	belongs to the nudix hydrolase family
GO994_18380	COG3066	DNA modification
GO994_18390	COG0335	large ribosomal subunit rRNA binding
GO994_18395	COG0336	Belongs to the RNA methyltransferase TrmD family
GO994_18400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO994_18405	COG0228	four-way junction DNA binding
GO994_18410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO994_18415	COG4137	Cytochrome C assembly protein
GO994_18420	COG4536	flavin adenine dinucleotide binding
GO994_18425	COG1959	2 iron, 2 sulfur cluster binding
GO994_18430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO994_18430	COG1017	nitric oxide dioxygenase activity
GO994_18435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GO994_18440	COG0039	L-malate dehydrogenase activity
GO994_18445	COG4160	amino acid transport
GO994_18450	COG4215	(ABC) transporter
GO994_18455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_18460	COG1126	abc transporter atp-binding protein
GO994_18465	COG1438	arginine binding
GO994_18470	COG2837	iron assimilation
GO994_18475	COG3842	ATPase activity
GO994_18485	COG1840	ABC-type Fe3 transport system, periplasmic component
GO994_18490	COG0347	Belongs to the P(II) protein family
GO994_18510	COG0004	ammonium transporteR
GO994_18515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO994_18530	COG0084	hydrolase, TatD family'
GO994_18545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO994_18550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO994_18555	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO994_18560	COG0813	purine-nucleoside phosphorylase activity
GO994_18570	COG0560	Phosphoserine phosphatase
GO994_18595	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GO994_18605	COG0776	regulation of translation
GO994_18620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO994_18625	COG0735	belongs to the Fur family
GO994_18645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO994_18650	COG0513	Belongs to the DEAD box helicase family
GO994_18655	COG3022	response to hydroperoxide
GO994_18670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO994_18675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO994_18680	COG0762	integral membrane protein
GO994_18685	COG1872	DUF167
GO994_18700	COG4166	transmembrane transport
GO994_18710	COG0110	maltose O-acetyltransferase activity
GO994_18720	COG1024	Enoyl-CoA hydratase
GO994_18735	COG4221	oxidoreductase activity
GO994_18745	COG2957	Belongs to the agmatine deiminase family
GO994_18775	COG0004	ammonium transporteR
GO994_18780	COG0347	Belongs to the P(II) protein family
GO994_18785	COG0745	RESPONSE REGULATOR receiver
GO994_18785	COG3706	GGDEF domain
GO994_18805	COG3706	GGDEF domain
GO994_18815	COG1278	Cold shock
GO994_18825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO994_18830	COG2197	response regulator
GO994_18865	COG3568	Endonuclease Exonuclease Phosphatase
GO994_18880	COG0513	Belongs to the DEAD box helicase family
GO994_18920	COG1448	Aminotransferase
GO994_18935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO994_18940	COG1328	CTP reductase activity
GO994_18980	COG1215	transferase activity, transferring glycosyl groups
GO994_18985	COG0726	polysaccharide deacetylase
GO994_18985	COG1649	PFAM Uncharacterised BCR, COG1649
GO994_19030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GO994_19035	COG4208	sulfate ABC transporter
GO994_19040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GO994_19050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GO994_19065	COG3174	membrane
GO994_19070	COG0110	maltose O-acetyltransferase activity
GO994_19100	COG1942	4-Oxalocrotonate Tautomerase
GO994_19110	COG0583	DNA-binding transcription factor activity
GO994_19115	COG0165	Argininosuccinate lyase
GO994_19155	COG0814	amino acid
GO994_19160	COG3932	Exopolysaccharide synthesis, ExoD
GO994_19215	COG1494	fructose-1,6-bisphosphatase
GO994_19230	COG2959	enzyme of heme biosynthesis
GO994_19240	COG0181	hydroxymethylbilane synthase activity
GO994_19245	COG3072	Adenylate cyclase
GO994_19250	COG0400	carboxylic ester hydrolase activity
GO994_19255	COG1965	Belongs to the frataxin family
GO994_19265	COG0019	diaminopimelate decarboxylase activity
GO994_19270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO994_19285	COG1011	Hydrolase
GO994_19295	COG0668	transmembrane transport
GO994_19305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GO994_19310	COG0561	phosphatase activity
GO994_19325	COG1129	ABC transporter
GO994_19325	COG0842	Transport permease protein
GO994_19335	COG1546	Belongs to the CinA family
GO994_19335	COG1058	Belongs to the CinA family
GO994_19340	COG1418	mRNA catabolic process
GO994_19345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO994_19355	COG1522	sequence-specific DNA binding
GO994_19360	COG1368	sulfuric ester hydrolase activity
GO994_19380	COG1285	pathogenesis
GO994_19400	COG4221	oxidoreductase activity
GO994_19420	COG1979	alcohol dehydrogenase
GO994_19430	COG2873	o-acetylhomoserine
GO994_19440	COG4533	DNA binding
GO994_19445	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GO994_19460	COG5380	lipid catabolic process
GO994_19465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO994_19480	COG2949	membrane
GO994_19485	COG3291	Pkd domain containing protein
GO994_19510	COG0187	DNA topoisomerase II activity
GO994_19520	COG1051	belongs to the nudix hydrolase family
GO994_19525	COG3150	esterase
GO994_19535	COG3151	Protein conserved in bacteria
GO994_19540	COG0494	nUDIX hydrolase
GO994_19545	COG1538	Outer membrane efflux protein
GO994_19550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO994_19550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GO994_19555	COG1560	Kdo2-lipid A biosynthetic process
GO994_19570	COG1392	Phosphate transport regulator
GO994_19575	COG0306	phosphate transporter
GO994_19580	COG0617	tRNA 3'-terminal CCA addition
GO994_19585	COG3409	Peptidoglycan-binding domain 1 protein
GO994_19585	COG3267	Type II secretory pathway component ExeA
GO994_19595	COG1194	a g-specific adenine glycosylase
GO994_19600	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GO994_19610	COG3111	PFAM Bacterial OB fold (BOF) protein
GO994_19615	COG3240	lipase activity
GO994_19630	COG3009	Protein conserved in bacteria
GO994_19635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO994_19635	COG3008	intermembrane lipid transfer
GO994_19640	COG2995	paraquat-inducible protein a
GO994_19650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO994_19665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO994_19670	COG2813	Specifically methylates the guanine in position
GO994_19675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO994_19680	COG0297	glycogen (starch) synthase activity
GO994_19715	COG1757	Na H antiporter
GO994_19725	COG0110	maltose O-acetyltransferase activity
GO994_19730	COG0366	Alpha amylase catalytic
GO994_19735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO994_19735	COG1263	PTS System
GO994_19750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO994_19755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO994_19760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO994_19760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO994_19765	COG2723	6-phospho-beta-galactosidase activity
GO994_19770	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO994_19775	COG1940	carbohydrate kinase activity
GO994_19785	COG1609	Transcriptional regulator
GO994_19795	COG0252	asparaginase activity
GO994_19810	COG1803	Methylglyoxal synthase
GO994_19835	COG1444	tRNA N-acetyltransferase activity
GO994_19840	COG1028	Short-chain dehydrogenase reductase Sdr
GO994_19845	COG0784	Response regulator, receiver
GO994_19845	COG0835	chemotaxis
GO994_19885	COG5433	transposase activity
GO994_19890	COG0582	viral genome integration into host DNA
GO994_19905	COG0795	lipopolysaccharide-transporting ATPase activity
GO994_19910	COG0795	lipopolysaccharide-transporting ATPase activity
GO994_19915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO994_19920	COG2927	DNA polymerase III (CHI subunit)
GO994_19935	COG0586	Pfam SNARE associated Golgi protein
GO994_19940	COG1686	Belongs to the peptidase S11 family
GO994_19965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO994_19970	COG0527	aspartate kinase activity
GO994_19975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO994_19985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO994_19995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO994_20030	COG1380	Effector of murein hydrolase LrgA
GO994_20035	COG1346	cytolysis
GO994_20050	COG0460	homoserine dehydrogenase
GO994_20050	COG0527	aspartate kinase activity
GO994_20055	COG0626	cystathionine gamma-synthase activity
GO994_20070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO994_20075	COG0814	amino acid
GO994_20080	COG1218	3'(2'),5'-bisphosphate nucleotidase
GO994_20085	COG0494	nUDIX hydrolase
GO994_20090	COG1011	Hydrolase
GO994_20095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO994_20110	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO994_20120	COG3156	type II secretion system protein K
GO994_20125	COG4795	General secretion pathway protein
GO994_20130	COG2165	general secretion pathway protein
GO994_20140	COG2165	general secretion pathway protein
GO994_20145	COG1459	type II secretion system
GO994_20150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO994_20170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO994_20175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO994_20195	COG0456	acetyltransferase
GO994_20200	COG3133	Outer membrane lipoprotein
GO994_20215	COG2771	luxR family
GO994_20230	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GO994_20250	COG0246	Mannitol dehydrogenase
GO994_20255	COG3722	fumarate hydratase activity
GO994_20260	COG3263	regulation of cellular component size
GO994_20265	COG0484	heat shock protein binding
GO994_20285	COG1671	Belongs to the UPF0178 family
GO994_20300	COG1988	membrane-bound metal-dependent
GO994_20305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO994_20325	COG0513	Belongs to the DEAD box helicase family
GO994_20345	COG5433	transposase activity
GO994_20360	COG1575	Belongs to the MenA family. Type 1 subfamily
GO994_20365	COG1169	isochorismate synthase
GO994_20370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO994_20375	COG0596	Alpha beta hydrolase
GO994_20380	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO994_20390	COG0318	PFAM AMP-dependent synthetase and ligase
GO994_20415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO994_20435	COG1929	Belongs to the glycerate kinase type-1 family
GO994_20440	COG2610	gluconate transmembrane transporter activity
GO994_20445	COG3835	regulator
GO994_20450	COG3112	Uncharacterised protein family (UPF0231)
GO994_20520	COG2259	Doxx family
GO994_20525	COG3118	belongs to the thioredoxin family
GO994_20545	COG0204	Acyl-transferase
GO994_20565	COG2827	Endonuclease containing a URI domain
GO994_20580	COG1573	uracil-dna glycosylase
GO994_20590	COG0583	DNA-binding transcription factor activity
GO994_20595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO994_20600	COG1121	(ABC) transporter
GO994_20605	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GO994_20625	COG0739	heme binding
GO994_20635	COG3068	Protein conserved in bacteria
GO994_20655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO994_20675	COG0798	PFAM Bile acid sodium symporter
GO994_20680	COG1393	Belongs to the ArsC family
GO994_20690	COG2072	flavoprotein involved in K transport
GO994_20700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO994_20710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO994_20735	COG5433	transposase activity
GO994_20740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO994_20745	COG1086	Polysaccharide biosynthesis protein
GO994_20750	COG0366	Alpha amylase catalytic
GO994_20765	COG0443	Heat shock 70 kDa protein
GO994_20770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO994_20775	COG3045	CreA protein
GO994_20785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO994_20790	COG0174	glutamine synthetase
GO994_20810	COG3842	ATPase activity
GO994_20815	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO994_20820	COG1177	transmembrane transport
GO994_20825	COG2258	MOSC domain
GO994_20840	COG2050	protein possibly involved in aromatic compounds catabolism
GO994_20845	COG0514	ATP-dependent DNA helicase (RecQ)
GO994_20865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO994_20870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO994_20880	COG2239	Acts as a magnesium transporter
GO994_20885	COG1648	precorrin-2 dehydrogenase activity
GO994_20885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO994_20890	COG2116	formate transmembrane transporter activity
GO994_20895	COG2146	nitrite reductase [NAD(P)H] activity
GO994_20900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO994_20915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO994_20920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO994_20930	COG0018	arginyl-trna synthetase
GO994_20940	COG1595	DNA-templated transcription, initiation
GO994_20950	COG1968	undecaprenyl-diphosphatase activity
GO994_20955	COG0667	Aldo Keto reductase
GO994_20960	COG2017	converts alpha-aldose to the beta-anomer
GO994_20965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO994_20975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO994_20980	COG1609	Transcriptional regulator
GO994_20985	COG3250	beta-galactosidase activity
GO994_21000	COG4211	Belongs to the binding-protein-dependent transport system permease family
GO994_21010	COG3328	transposase activity
GO994_21030	COG5433	transposase activity
GO994_21060	COG0753	catalase activity
GO994_21065	COG1247	-acetyltransferase
GO994_21085	COG2203	Gaf domain
GO994_21085	COG2199	diguanylate cyclase activity
GO994_21095	COG3842	ATPase activity
GO994_21105	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO994_21130	COG0583	DNA-binding transcription factor activity
GO994_21140	COG1741	Belongs to the pirin family
GO994_21145	COG2259	Doxx family
GO994_21150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO994_21155	COG1074	ATP-dependent DNA helicase activity
GO994_21160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO994_21235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO994_21240	COG0745	RESPONSE REGULATOR receiver
GO994_21245	COG2205	protein histidine kinase activity
GO994_21255	COG0281	malic enzyme
GO994_21260	COG0702	epimerase
GO994_21265	COG0254	rRNA binding
GO994_21270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO994_21280	COG1309	transcriptional regulator
GO994_21300	COG0129	dihydroxy-acid dehydratase activity
GO994_21305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO994_21310	COG3978	acetolactate synthase activity
GO994_21325	COG0606	chelatase, subunit chli
GO994_21335	COG1683	Conserved Protein
GO994_21345	COG1335	isochorismatase
GO994_21355	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GO994_21360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GO994_21370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO994_21375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO994_21385	COG3084	Protein conserved in bacteria
GO994_21390	COG3706	GGDEF domain
GO994_21390	COG2203	Gaf domain
GO994_21390	COG5001	Diguanylate cyclase
GO994_21390	COG4251	negative regulation of phosphorylation
GO994_21405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO994_21415	COG1561	YicC-like family, N-terminal region
GO994_21460	COG5433	transposase activity
GO994_21475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO994_21490	COG1063	alcohol dehydrogenase
GO994_21515	COG0210	DNA helicase
GO994_21520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO994_21525	COG2166	iron-sulfur cluster assembly
GO994_21530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO994_21560	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GO994_21565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO994_21570	COG1739	Uncharacterized protein family UPF0029
GO994_21575	COG0006	proline dipeptidase activity
GO994_21580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO994_21585	COG1024	Enoyl-CoA hydratase
GO994_21585	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO994_21590	COG0183	Belongs to the thiolase family
GO994_21595	COG0745	RESPONSE REGULATOR receiver
GO994_21600	COG2205	protein histidine kinase activity
GO994_21615	COG0425	Belongs to the sulfur carrier protein TusA family
GO994_21620	COG0251	oxidation-reduction process
GO994_21625	COG2885	chlorophyll binding
GO994_21630	COG2818	Glycosylase
GO994_21635	COG0752	glycyl-tRNA synthetase alpha subunit
GO994_21640	COG0751	glycine-tRNA ligase activity
GO994_21650	COG3328	transposase activity
GO994_21690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO994_21700	COG2202	Pas domain
GO994_21700	COG2200	EAL domain
GO994_21700	COG2199	diguanylate cyclase activity
GO994_21715	COG0814	amino acid
GO994_21720	COG0348	domain, Protein
GO994_21730	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO994_21735	COG0426	domain, Protein
GO994_21735	COG1773	rubredoxin
GO994_21740	COG3604	Transcriptional regulator
GO994_21745	COG2188	Transcriptional regulator
GO994_21750	COG5433	transposase activity
GO994_21775	COG1609	Transcriptional regulator
GO994_21785	COG0559	Belongs to the binding-protein-dependent transport system permease family
GO994_21815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO994_21840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO994_21850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO994_21855	COG3118	belongs to the thioredoxin family
GO994_21860	COG0513	Belongs to the DEAD box helicase family
GO994_21865	COG0248	Ppx GppA phosphatase
GO994_21875	COG0742	ribosomal rna small subunit methyltransferase
GO994_21880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO994_21900	COG0084	hydrolase, TatD family'
GO994_21905	COG0805	protein transport
GO994_21910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO994_21920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GO994_21925	COG3165	ubiquinone biosynthetic process from chorismate
GO994_21935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO994_21940	COG0402	S-adenosylhomocysteine deaminase activity
GO994_21980	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GO994_21985	COG0848	biopolymer transport protein
GO994_21990	COG0811	peptide transport
GO994_21995	COG0811	peptide transport
GO994_22005	COG2771	luxR family
GO994_22010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO994_22015	COG1349	DNA-binding transcription factor activity
GO994_22020	COG0745	RESPONSE REGULATOR receiver
GO994_22035	COG4452	Inner membrane protein CreD
GO994_22040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO994_22045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO994_22050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO994_22055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO994_22060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO994_22065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO994_22070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO994_22080	COG0356	it plays a direct role in the translocation of protons across the membrane
GO994_22085	COG3312	ion transport
GO994_22090	COG1475	DNA binding
GO994_22095	COG1192	Involved in chromosome partitioning
GO994_22100	COG0357	Ribosomal RNA small subunit methyltransferase G
GO994_22105	COG0445	tRNA wobble uridine modification
GO994_22110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO994_22115	COG4774	siderophore transport
GO994_22120	COG4615	Cyclic peptide transporter
GO994_22125	COG1120	ATPase activity
GO994_22130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO994_22140	COG4774	siderophore transport
GO994_22145	COG4607	ABC-type enterochelin transport system periplasmic component
GO994_22150	COG4604	ABC transporter, ATP-binding protein
GO994_22155	COG4605	iron ion homeostasis
GO994_22160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO994_22180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO994_22190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO994_22205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO994_22210	COG0706	membrane insertase activity
GO994_22215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO994_22220	COG0594	ribonuclease P activity
GO994_22225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO994_22260	COG1317	bacterial-type flagellum organization
GO994_22350	COG0457	Tetratricopeptide repeat
GO994_22420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO994_22425	COG4790	Type iii secretion
GO994_22430	COG4794	Type iii secretion
GO994_22440	COG4792	protein secretion
GO994_22480	COG1192	Involved in chromosome partitioning
GO994_22565	COG2336	PFAM SpoVT AbrB
GO994_22625	COG1484	DNA-dependent DNA replication
GO994_22685	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO994_22695	COG1192	Involved in chromosome partitioning
GO994_22705	COG3328	transposase activity