locus-tag	class	description
GO993_00060	COG0848	biopolymer transport protein
GO993_00065	COG0811	peptide transport
GO993_00080	COG4206	TonB-dependent receptor
GO993_00100	COG4239	(ABC) transporter, permease
GO993_00110	COG0444	Belongs to the ABC transporter superfamily
GO993_00115	COG4608	Belongs to the ABC transporter superfamily
GO993_00120	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO993_00130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO993_00145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO993_00150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO993_00180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO993_00180	COG1522	sequence-specific DNA binding
GO993_00200	COG1858	cytochrome C peroxidase
GO993_00240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO993_00245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO993_00255	COG0318	PFAM AMP-dependent synthetase and ligase
GO993_00260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO993_00270	COG2986	histidine ammonia-lyase
GO993_00295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO993_00305	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_00320	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO993_00340	COG5433	transposase activity
GO993_00355	COG3610	response to peptide
GO993_00365	COG4175	Glycine betaine
GO993_00370	COG4176	ABC-type proline glycine betaine transport system permease component
GO993_00375	COG2113	Glycine betaine
GO993_00380	COG0175	sulfate reduction
GO993_00385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO993_00390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO993_00395	COG0384	phenazine biosynthesis protein PhzF
GO993_00400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO993_00425	COG3139	Protein of unknown function (DUF1315)
GO993_00475	COG4302	ethanolamine ammonia-lyase activity
GO993_00480	COG4303	Ethanolamine ammonia lyase large subunit
GO993_00490	COG2264	protein methyltransferase activity
GO993_00495	COG0604	alcohol dehydrogenase
GO993_00510	COG1263	PTS System
GO993_00510	COG2190	(PTS) system
GO993_00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO993_00525	COG0439	Biotin carboxylase
GO993_00530	COG0511	ligase activity, forming carbon-carbon bonds
GO993_00535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO993_00540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO993_00570	COG3381	protein complex oligomerization
GO993_00580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO993_00595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO993_00600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO993_00600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO993_00615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO993_00620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO993_00625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO993_00630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO993_00655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO993_00660	COG0142	geranyltranstransferase activity
GO993_00665	COG1722	exodeoxyribonuclease VII activity
GO993_00675	COG1360	Flagellar Motor Protein
GO993_00705	COG1534	Rna-binding protein
GO993_00710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GO993_00720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO993_00725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO993_00730	COG0149	triose-phosphate isomerase activity
GO993_00735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO993_00750	COG0779	Required for maturation of 30S ribosomal subunits
GO993_00755	COG0195	Participates in both transcription termination and antitermination
GO993_00760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO993_00765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO993_00770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO993_00775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO993_00780	COG1185	polyribonucleotide nucleotidyltransferase activity
GO993_00785	COG2211	Major facilitator Superfamily
GO993_00790	COG3706	GGDEF domain
GO993_00795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO993_00800	COG1422	Protein of unknown function (DUF1090)
GO993_00875	COG0312	modulator of DNA gyrase
GO993_00890	COG4974	Belongs to the 'phage' integrase family
GO993_00910	COG1970	mechanosensitive ion channel activity
GO993_00915	COG5433	transposase activity
GO993_00925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO993_00940	COG3545	Serine hydrolase
GO993_00945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO993_01020	COG5433	transposase activity
GO993_01045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO993_01050	COG0321	lipoyl(octanoyl) transferase activity
GO993_01055	COG2921	Belongs to the UPF0250 family
GO993_01060	COG1686	Belongs to the peptidase S11 family
GO993_01065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO993_01070	COG2951	lytic endotransglycosylase activity
GO993_01075	COG0772	Belongs to the SEDS family
GO993_01080	COG0768	penicillin binding
GO993_01085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO993_01090	COG0799	negative regulation of ribosome biogenesis
GO993_01095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO993_01115	COG0495	leucyl-tRNA aminoacylation
GO993_01120	COG2888	peptidyl-tyrosine sulfation
GO993_01125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO993_01130	COG4535	Mg2 and Co2 transporter CorC
GO993_01135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO993_01140	COG1702	phosphate starvation-inducible protein PhoH
GO993_01145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO993_01150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO993_01160	COG3706	GGDEF domain
GO993_01175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO993_01195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO993_01205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO993_01215	COG0516	GMP reductase activity
GO993_01230	COG0745	RESPONSE REGULATOR receiver
GO993_01265	COG3214	Protein conserved in bacteria
GO993_01285	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO993_01290	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO993_01295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO993_01300	COG1053	succinate dehydrogenase
GO993_01310	COG0584	glycerophosphoryl diester phosphodiesterase
GO993_01315	COG3264	Mechanosensitive ion channel
GO993_01315	COG1511	domain protein
GO993_01330	COG0739	heme binding
GO993_01345	COG0583	DNA-binding transcription factor activity
GO993_01365	COG0583	DNA-binding transcription factor activity
GO993_01370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO993_01400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO993_01405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO993_01415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO993_01420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO993_01425	COG0546	phosphoglycolate phosphatase activity
GO993_01430	COG0180	Tryptophanyl-tRNA synthetase
GO993_01445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO993_01455	COG1012	belongs to the aldehyde dehydrogenase family
GO993_01465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO993_01495	COG3089	Belongs to the UPF0270 family
GO993_01520	COG0429	hydrolase of the alpha beta-hydrolase fold
GO993_01525	COG0835	chemotaxis
GO993_01525	COG0784	Response regulator, receiver
GO993_01535	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO993_01540	COG1047	Peptidyl-prolyl cis-trans
GO993_01555	COG0545	Peptidyl-prolyl cis-trans isomerase
GO993_01580	COG0737	Belongs to the 5'-nucleotidase family
GO993_01585	COG2200	EAL domain
GO993_01600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO993_01605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO993_01615	COG2203	Gaf domain
GO993_01615	COG2199	diguanylate cyclase activity
GO993_01615	COG2200	EAL domain
GO993_01620	COG5433	transposase activity
GO993_01635	COG5433	transposase activity
GO993_01665	COG0300	oxidoreductase activity
GO993_01690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO993_01705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO993_01715	COG3813	Protein conserved in bacteria
GO993_01740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO993_01750	COG0745	RESPONSE REGULATOR receiver
GO993_01770	COG0835	chemotaxis
GO993_01795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO993_01800	COG2201	protein-glutamate methylesterase activity
GO993_01805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO993_01855	COG2133	pyrroloquinoline quinone binding
GO993_01880	COG1605	Chorismate mutase
GO993_01880	COG0077	Prephenate dehydratase
GO993_01910	COG3272	Protein of unknown function (DUF1722)
GO993_01920	COG0415	Belongs to the DNA photolyase family
GO993_01970	COG0783	Belongs to the Dps family
GO993_01975	COG1151	hydroxylamine reductase activity
GO993_01985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO993_01990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO993_01990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO993_02025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO993_02030	COG1666	GTP binding
GO993_02035	COG3248	Nucleoside-binding outer membrane protein
GO993_02040	COG2211	Major facilitator Superfamily
GO993_02050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO993_02060	COG2813	Specifically methylates the guanine in position
GO993_02065	COG0271	Belongs to the BolA IbaG family
GO993_02070	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO993_02075	COG1805	sodium ion transport
GO993_02080	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO993_02085	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO993_02090	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO993_02095	COG2871	sodium ion transport
GO993_02100	COG1477	protein flavinylation
GO993_02115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO993_02120	COG0840	transmembrane signaling receptor activity
GO993_02125	COG0583	DNA-binding transcription factor activity
GO993_02135	COG2363	Small membrane protein
GO993_02140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GO993_02150	COG0473	3-isopropylmalate dehydrogenase activity
GO993_02155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO993_02160	COG1611	Belongs to the LOG family
GO993_02165	COG3706	GGDEF domain
GO993_02175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO993_02175	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO993_02185	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GO993_02210	COG3098	single-species biofilm formation
GO993_02225	COG4580	involved in the transport of maltose and maltodextrins
GO993_02235	COG1263	PTS System
GO993_02235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO993_02245	COG2171	N-acyltransferase activity
GO993_02260	COG0052	Belongs to the universal ribosomal protein uS2 family
GO993_02265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO993_02270	COG0528	UMP kinase activity
GO993_02275	COG0233	cytoplasmic translational termination
GO993_02280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO993_02285	COG0575	Belongs to the CDS family
GO993_02290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO993_02295	COG0750	zinc metalloprotease
GO993_02310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO993_02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO993_02320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO993_02325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO993_02330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO993_02340	COG0825	malonyl-CoA metabolic process
GO993_02350	COG0531	amino acid
GO993_02355	COG1982	Orn Lys Arg decarboxylase major
GO993_02360	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GO993_02375	COG0814	amino acid
GO993_02380	COG0531	amino acid
GO993_02390	COG0488	(ABC) transporter
GO993_02405	COG0037	tRNA processing
GO993_02410	COG3706	GGDEF domain
GO993_02465	COG0366	Alpha amylase catalytic
GO993_02485	COG0583	DNA-binding transcription factor activity
GO993_02495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO993_02505	COG0583	DNA-binding transcription factor activity
GO993_02510	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_02515	COG0616	signal peptide processing
GO993_02520	COG3724	N-succinylarginine dihydrolase activity
GO993_02560	COG4608	Belongs to the ABC transporter superfamily
GO993_02565	COG0444	Belongs to the ABC transporter superfamily
GO993_02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO993_02620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO993_02635	COG0746	molybdenum cofactor guanylyltransferase activity
GO993_02645	COG4662	Binding-protein-dependent transport system inner membrane component
GO993_02670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO993_02675	COG3328	transposase activity
GO993_02725	COG0582	viral genome integration into host DNA
GO993_02735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO993_02745	COG2867	negative regulation of translational initiation
GO993_02755	COG0702	epimerase
GO993_02760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO993_02790	COG4964	Belongs to the GSP D family
GO993_02840	COG1454	alcohol dehydrogenase
GO993_02855	COG1957	nucleoside hydrolase
GO993_02875	COG0840	transmembrane signaling receptor activity
GO993_02880	COG1280	lysine exporter protein (LysE YggA)
GO993_02915	COG3263	regulation of cellular component size
GO993_02925	COG1876	peptidase activity
GO993_02930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO993_02935	COG1393	Belongs to the ArsC family
GO993_02940	COG0583	DNA-binding transcription factor activity
GO993_02955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO993_02960	COG0017	Asparaginyl-tRNA synthetase
GO993_02980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO993_02985	COG0156	8-amino-7-oxononanoate synthase activity
GO993_02990	COG2226	methyltransferase
GO993_02990	COG1073	alpha beta
GO993_02995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO993_03000	COG0501	Belongs to the peptidase M48B family
GO993_03010	COG0633	Ferredoxin
GO993_03010	COG3217	Mosc domain protein beta barrel domain protein
GO993_03010	COG3217	Mosc domain protein beta barrel domain protein
GO993_03010	COG0633	Ferredoxin
GO993_03040	COG2841	Protein conserved in bacteria
GO993_03055	COG0534	Mate efflux family protein
GO993_03095	COG1309	transcriptional regulator
GO993_03110	COG0791	NLP P60 protein
GO993_03125	COG0583	DNA-binding transcription factor activity
GO993_03135	COG0784	Response regulator, receiver
GO993_03135	COG0643	Histidine kinase
GO993_03135	COG2198	Histidine kinase
GO993_03140	COG2201	protein-glutamate methylesterase activity
GO993_03145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO993_03150	COG1360	Flagellar Motor Protein
GO993_03155	COG1192	Involved in chromosome partitioning
GO993_03165	COG0835	chemotaxis
GO993_03185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO993_03190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO993_03195	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO993_03200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GO993_03210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO993_03215	COG3088	subunit of a heme lyase
GO993_03215	COG4235	cytochrome complex assembly
GO993_03235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO993_03240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO993_03240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO993_03255	COG0259	pyridoxamine-phosphate oxidase activity
GO993_03270	COG3153	acetyltransferase
GO993_03290	COG2850	peptidyl-arginine hydroxylation
GO993_03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO993_03300	COG2915	High frequency lysogenization protein hflD homolog
GO993_03305	COG0482	sulfurtransferase activity
GO993_03325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO993_03400	COG2119	membrane
GO993_03455	COG2205	protein histidine kinase activity
GO993_03455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_03465	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GO993_03470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO993_03475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO993_03485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GO993_03505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO993_03510	COG0505	Belongs to the CarA family
GO993_03515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO993_03560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO993_03565	COG0513	Belongs to the DEAD box helicase family
GO993_03595	COG0789	Transcriptional regulator
GO993_03610	COG0493	'glutamate synthase
GO993_03615	COG0069	glutamate synthase activity
GO993_03615	COG0067	glutamate synthase
GO993_03615	COG0070	glutamate synthase
GO993_03620	COG1242	4 iron, 4 sulfur cluster binding
GO993_03670	COG5433	transposase activity
GO993_03715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO993_03720	COG1288	antiporter activity
GO993_03735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO993_03745	COG1061	Type III restriction enzyme res subunit
GO993_03750	COG1566	PFAM secretion protein HlyD family protein
GO993_03760	COG1966	Carbon starvation protein
GO993_03765	COG3279	Response regulator of the LytR AlgR family
GO993_03770	COG3275	phosphorelay sensor kinase activity
GO993_03790	COG1012	belongs to the aldehyde dehydrogenase family
GO993_03790	COG1454	alcohol dehydrogenase
GO993_03800	COG2095	MarC family integral membrane protein
GO993_03810	COG0601	transmembrane transport
GO993_03815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO993_03820	COG0444	Belongs to the ABC transporter superfamily
GO993_03835	COG0861	Integral membrane protein TerC family
GO993_03840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO993_03855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO993_03895	COG0537	adenosine 5'-monophosphoramidase activity
GO993_03930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO993_03935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO993_03970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO993_03975	COG1360	Flagellar Motor Protein
GO993_03995	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO993_04015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_04045	COG0516	GMP reductase activity
GO993_04045	COG0517	IMP dehydrogenase activity
GO993_04050	COG0519	Catalyzes the synthesis of GMP from XMP
GO993_04050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO993_04070	COG5433	transposase activity
GO993_04095	COG2062	phosphohistidine phosphatase, SixA
GO993_04105	COG0697	spore germination
GO993_04110	COG4166	transmembrane transport
GO993_04115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GO993_04130	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO993_04135	COG1136	(ABC) transporter
GO993_04140	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO993_04155	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO993_04160	COG0740	serine-type endopeptidase activity
GO993_04165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO993_04170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO993_04175	COG0776	regulation of translation
GO993_04180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO993_04185	COG0488	(ABC) transporter
GO993_04190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO993_04195	COG3162	membrane
GO993_04220	COG1024	Enoyl-CoA hydratase
GO993_04220	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO993_04225	COG1115	amino acid carrier protein
GO993_04230	COG0456	acetyltransferase
GO993_04240	COG1584	GPR1 FUN34 yaaH family protein
GO993_04260	COG5433	transposase activity
GO993_04285	COG1435	thymidine kinase activity
GO993_04305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO993_04310	COG5433	transposase activity
GO993_04325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GO993_04330	COG0437	4 iron, 4 sulfur cluster binding
GO993_04335	COG5557	Pfam Polysulphide reductase, NrfD
GO993_04340	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GO993_04345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO993_04350	COG1773	rubredoxin
GO993_04380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO993_04385	COG0375	protein maturation
GO993_04390	COG0309	Hydrogenase expression formation protein (HypE)
GO993_04400	COG0298	carbon dioxide binding
GO993_04415	COG1921	L-seryl-tRNASec selenium transferase activity
GO993_04425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO993_04435	COG3260	NADH ubiquinone oxidoreductase 20
GO993_04440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO993_04445	COG3261	NADH dehydrogenase
GO993_04445	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GO993_04450	COG0650	Formate hydrogenlyase subunit 4
GO993_04455	COG0651	ATP synthesis coupled electron transport
GO993_04460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO993_04465	COG3158	transport of potassium into the cell
GO993_04550	COG1846	Transcriptional regulator
GO993_04550	COG1940	carbohydrate kinase activity
GO993_04555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO993_04560	COG0363	glucosamine-6-phosphate deaminase activity
GO993_04575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO993_04580	COG0735	belongs to the Fur family
GO993_04590	COG0716	FMN binding
GO993_04605	COG0596	Alpha beta hydrolase
GO993_04610	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GO993_04625	COG1846	Transcriptional regulator
GO993_04635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO993_04645	COG4135	transport system, permease component
GO993_04655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO993_04660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO993_04670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO993_04675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO993_04710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO993_04735	COG1607	acyl-coa hydrolase
GO993_04745	COG3021	interspecies interaction between organisms
GO993_04750	COG0741	lytic transglycosylase activity
GO993_04750	COG1388	LysM domain
GO993_04755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO993_04760	COG2226	methyltransferase
GO993_04765	COG0328	RNA-DNA hybrid ribonuclease activity
GO993_04770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO993_04805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO993_04840	COG2197	response regulator
GO993_04845	COG3850	Histidine kinase
GO993_04855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO993_04865	COG0243	molybdopterin cofactor binding
GO993_04885	COG3005	denitrification pathway
GO993_04920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO993_04925	COG0596	Alpha beta hydrolase
GO993_04950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO993_04965	COG0840	transmembrane signaling receptor activity
GO993_04980	COG0583	DNA-binding transcription factor activity
GO993_04985	COG2353	YceI-like domain
GO993_05035	COG1166	arginine decarboxylase activity
GO993_05050	COG0346	lactoylglutathione lyase activity
GO993_05060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO993_05065	COG1187	pseudouridine synthase activity
GO993_05080	COG0583	DNA-binding transcription factor activity
GO993_05100	COG2979	Protein of unknown function (DUF533)
GO993_05105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO993_05140	COG2814	Major facilitator Superfamily
GO993_05145	COG0656	L-ascorbic acid biosynthetic process
GO993_05150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO993_05180	COG0583	DNA-binding transcription factor activity
GO993_05185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO993_05190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO993_05195	COG2271	Major facilitator Superfamily
GO993_05200	COG1349	DNA-binding transcription factor activity
GO993_05210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO993_05215	COG0584	glycerophosphoryl diester phosphodiesterase
GO993_05220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO993_05225	COG0287	Prephenate dehydrogenase
GO993_05225	COG1605	Chorismate mutase
GO993_05230	COG0583	DNA-binding transcription factor activity
GO993_05235	COG3085	chromosome segregation
GO993_05240	COG4574	serine-type endopeptidase inhibitor activity
GO993_05260	COG1770	oligopeptidase
GO993_05265	COG4771	TonB-dependent receptor
GO993_05270	COG3083	sulfuric ester hydrolase activity
GO993_05275	COG3082	Protein of unknown function (DUF1414)
GO993_05290	COG2182	Extracellular solute-binding protein
GO993_05295	COG1175	transmembrane transport
GO993_05300	COG3833	ABC-type maltose transport systems, permease component
GO993_05305	COG3842	ATPase activity
GO993_05320	COG0628	permease
GO993_05325	COG0425	Belongs to the sulfur carrier protein TusA family
GO993_05330	COG4783	chaperone-mediated protein folding
GO993_05340	COG1393	Belongs to the ArsC family
GO993_05350	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GO993_05390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO993_05420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO993_05420	COG0301	tRNA thio-modification
GO993_05450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO993_05465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO993_05475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO993_05495	COG0483	inositol monophosphate 1-phosphatase activity
GO993_05520	COG0625	glutathione transferase activity
GO993_05555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO993_05560	COG0243	molybdopterin cofactor binding
GO993_05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO993_05585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO993_05590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO993_05595	COG0509	glycine decarboxylation via glycine cleavage system
GO993_05600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO993_05600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO993_05615	COG3634	alkyl hydroperoxide reductase activity
GO993_05625	COG0517	IMP dehydrogenase activity
GO993_05635	COG0343	queuine tRNA-ribosyltransferase activity
GO993_05640	COG1862	Preprotein translocase
GO993_05655	COG2897	thiosulfate sulfurtransferase activity
GO993_05665	COG0826	peptidase U32
GO993_05670	COG0826	peptidase U32
GO993_05675	COG3154	lipid carrier protein
GO993_05690	COG1959	2 iron, 2 sulfur cluster binding
GO993_05695	COG1104	cysteine desulfurase activity
GO993_05700	COG0822	iron-sulfur transferase activity
GO993_05710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO993_05720	COG0633	Ferredoxin
GO993_05735	COG0105	UTP biosynthetic process
GO993_05740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO993_05750	COG1426	Protein conserved in bacteria
GO993_05760	COG0124	histidyl-tRNA synthetase
GO993_05765	COG2976	Protein conserved in bacteria
GO993_05775	COG1160	GTP binding
GO993_05780	COG1645	bacterial-type flagellum-dependent swarming motility
GO993_05785	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO993_05790	COG0047	phosphoribosylformylglycinamidine synthase activity
GO993_05790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO993_05820	COG5433	transposase activity
GO993_05850	COG1024	Enoyl-CoA hydratase
GO993_05855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO993_05860	COG1960	acyl-CoA dehydrogenase activity
GO993_05875	COG1024	Enoyl-CoA hydratase
GO993_05880	COG1024	Enoyl-CoA hydratase
GO993_05900	COG0730	response to heat
GO993_05940	COG1609	Transcriptional regulator
GO993_05945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_05945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_05950	COG1105	Belongs to the carbohydrate kinase PfkB family
GO993_05955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO993_05955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO993_05955	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GO993_05960	COG3313	Fe-S protein
GO993_05965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GO993_05970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO993_05975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO993_05980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO993_06015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO993_06020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO993_06025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO993_06030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO993_06035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO993_06040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO993_06040	COG0072	phenylalanine-tRNA ligase activity
GO993_06045	COG0776	regulation of translation
GO993_06080	COG1609	Transcriptional regulator
GO993_06105	COG1869	D-ribose catabolic process
GO993_06125	COG0037	tRNA processing
GO993_06130	COG0589	response to stress
GO993_06135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO993_06150	COG2217	Heavy metal translocating P-type atpase
GO993_06160	COG2010	Cytochrome c
GO993_06175	COG3278	Belongs to the heme-copper respiratory oxidase family
GO993_06185	COG1956	GAF domain-containing protein
GO993_06190	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GO993_06200	COG0308	aminopeptidase N
GO993_06225	COG0167	dihydroorotate dehydrogenase activity
GO993_06245	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GO993_06265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO993_06270	COG0254	rRNA binding
GO993_06285	COG1451	nucleotide metabolic process
GO993_06300	COG3069	C4-dicarboxylate transmembrane transporter activity
GO993_06310	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO993_06310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO993_06315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO993_06340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO993_06345	COG1053	succinate dehydrogenase
GO993_06355	COG0567	Dehydrogenase, E1 component
GO993_06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO993_06365	COG0045	succinate-CoA ligase (ADP-forming) activity
GO993_06370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO993_06375	COG2983	Belongs to the UPF0260 family
GO993_06380	COG1882	Formate acetyltransferase
GO993_06385	COG2116	formate transmembrane transporter activity
GO993_06390	COG1944	ATP diphosphatase activity
GO993_06395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO993_06415	COG5433	transposase activity
GO993_06450	COG4681	YaeQ
GO993_06490	COG3134	Outer membrane lipoprotein
GO993_06500	COG1288	antiporter activity
GO993_06540	COG0058	SHG alpha-glucan phosphorylase activity
GO993_06545	COG0471	metal ion transport
GO993_06550	COG3118	belongs to the thioredoxin family
GO993_06565	COG1132	(ABC) transporter
GO993_06575	COG2501	S4 domain
GO993_06585	COG3243	poly(R)-hydroxyalkanoic acid synthase
GO993_06605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GO993_06610	COG2329	Antibiotic biosynthesis monooxygenase
GO993_06660	COG1742	UPF0060 membrane protein
GO993_06675	COG0513	Belongs to the DEAD box helicase family
GO993_06680	COG0386	Belongs to the glutathione peroxidase family
GO993_06690	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO993_06705	COG0730	response to heat
GO993_06710	COG0583	DNA-binding transcription factor activity
GO993_06725	COG3593	DNA synthesis involved in DNA repair
GO993_06785	COG1011	Hydrolase
GO993_06800	COG5433	transposase activity
GO993_06895	COG2840	Smr protein MutS2
GO993_06900	COG2890	protein-(glutamine-N5) methyltransferase activity
GO993_06905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO993_06915	COG0513	Belongs to the DEAD box helicase family
GO993_06920	COG5654	RES domain protein
GO993_06950	COG1067	ATP-dependent peptidase activity
GO993_06955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO993_06995	COG3620	sequence-specific DNA binding
GO993_07075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO993_07085	COG2995	paraquat-inducible protein a
GO993_07095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO993_07095	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GO993_07110	COG0084	hydrolase, TatD family'
GO993_07115	COG0470	DNA polymerase III
GO993_07120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO993_07125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO993_07130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO993_07135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO993_07140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO993_07145	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_07155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO993_07160	COG0416	fatty acid biosynthetic process
GO993_07165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GO993_07170	COG1399	metal-binding, possibly nucleic acid-binding protein
GO993_07200	COG0717	Belongs to the dCTP deaminase family
GO993_07205	COG0572	uridine kinase
GO993_07210	COG0489	protein tyrosine kinase activity
GO993_07215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO993_07215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO993_07225	COG1254	Belongs to the acylphosphatase family
GO993_07245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO993_07260	COG0709	Synthesizes selenophosphate from selenide and ATP
GO993_07275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO993_07290	COG0617	tRNA 3'-terminal CCA addition
GO993_07290	COG0517	IMP dehydrogenase activity
GO993_07290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GO993_07295	COG2197	response regulator
GO993_07305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO993_07310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO993_07315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO993_07320	COG2832	Protein of unknown function (DUF454)
GO993_07325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO993_07345	COG0318	PFAM AMP-dependent synthetase and ligase
GO993_07350	COG2267	carboxylic ester hydrolase activity
GO993_07360	COG1214	PFAM Peptidase M22, glycoprotease
GO993_07365	COG1199	ATP-dependent helicase activity
GO993_07375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO993_07380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO993_07385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO993_07390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO993_07390	COG0131	Imidazoleglycerol-phosphate dehydratase
GO993_07395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO993_07400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO993_07420	COG0107	imidazoleglycerol-phosphate synthase activity
GO993_07425	COG0140	phosphoribosyl-ATP diphosphatase activity
GO993_07425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO993_07435	COG2378	regulation of single-species biofilm formation
GO993_07465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO993_07475	COG0814	amino acid
GO993_07480	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GO993_07485	COG0514	ATP-dependent DNA helicase (RecQ)
GO993_07490	COG2766	serine protein kinase
GO993_07500	COG2719	SpoVR family
GO993_07505	COG2186	Transcriptional regulator
GO993_07510	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO993_07515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO993_07520	COG0586	Pfam SNARE associated Golgi protein
GO993_07540	COG2985	domain, Protein
GO993_07540	COG0569	domain protein
GO993_07565	COG4565	transcriptional regulatory protein
GO993_07575	COG1846	Transcriptional regulator
GO993_07575	COG1940	carbohydrate kinase activity
GO993_07585	COG3012	SEC-C Motif Domain Protein
GO993_07615	COG0437	4 iron, 4 sulfur cluster binding
GO993_07620	COG3301	Polysulphide reductase, NrfD
GO993_07635	COG4235	cytochrome complex assembly
GO993_07635	COG3088	subunit of a heme lyase
GO993_07650	COG3033	Beta-eliminating lyase
GO993_07665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO993_07720	COG2207	Transcriptional regulator
GO993_07720	COG3708	Transcriptional regulator
GO993_07785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO993_07790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO993_07795	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GO993_07805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO993_07820	COG0205	6-phosphofructokinase activity
GO993_07890	COG2824	Alkylphosphonate utilization operon protein PhnA
GO993_07900	COG0183	Belongs to the thiolase family
GO993_07945	COG2067	long-chain fatty acid transport protein
GO993_07950	COG2067	long-chain fatty acid transport protein
GO993_07955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO993_07975	COG3123	guanosine phosphorylase activity
GO993_07980	COG1760	l-serine dehydratase
GO993_07985	COG1760	l-serine dehydratase
GO993_07990	COG2951	lytic endotransglycosylase activity
GO993_07995	COG3100	YcgL domain-containing protein
GO993_08000	COG0850	regulation of cytokinetic process
GO993_08005	COG2894	cell division
GO993_08010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GO993_08015	COG3099	Belongs to the UPF0263 family
GO993_08065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO993_08075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO993_08080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO993_08090	COG0307	riboflavin synthase, alpha
GO993_08100	COG0534	Mate efflux family protein
GO993_08135	COG0417	DNA replication proofreading
GO993_08160	COG1560	Kdo2-lipid A biosynthetic process
GO993_08165	COG1560	Kdo2-lipid A biosynthetic process
GO993_08175	COG0583	DNA-binding transcription factor activity
GO993_08180	COG0673	inositol 2-dehydrogenase activity
GO993_08185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO993_08190	COG0583	DNA-binding transcription factor activity
GO993_08200	COG2723	6-phospho-beta-galactosidase activity
GO993_08210	COG5433	transposase activity
GO993_08280	COG1609	Transcriptional regulator
GO993_08285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO993_08295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO993_08305	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO993_08310	COG1129	ABC transporter
GO993_08315	COG1879	ABC-type sugar transport system periplasmic component
GO993_08320	COG1069	ribulokinase activity
GO993_08330	COG2160	L-arabinose isomerase activity
GO993_08335	COG0583	DNA-binding transcription factor activity
GO993_08345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO993_08360	COG2925	Exonuclease
GO993_08375	COG1380	Effector of murein hydrolase LrgA
GO993_08380	COG1346	cytolysis
GO993_08385	COG0295	cytidine deaminase activity
GO993_08390	COG1022	Amp-dependent synthetase and ligase
GO993_08405	COG0861	Integral membrane protein TerC family
GO993_08415	COG2199	diguanylate cyclase activity
GO993_08430	COG2154	pterin-4-alpha-carbinolamine dehydratase
GO993_08440	COG3768	UPF0283 membrane protein
GO993_08460	COG1842	Phage shock protein A
GO993_08485	COG4172	Belongs to the ABC transporter superfamily
GO993_08490	COG4172	Belongs to the ABC transporter superfamily
GO993_08500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO993_08505	COG1286	toxin biosynthetic process
GO993_08510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO993_08515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO993_08520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO993_08525	COG0531	amino acid
GO993_08525	COG1674	ftsk spoiiie
GO993_08545	COG0492	ferredoxin-NADP+ reductase activity
GO993_08560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO993_08565	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GO993_08570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO993_08575	COG0542	response to heat
GO993_08580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO993_08585	COG1278	Cold shock
GO993_08590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO993_08755	COG0697	spore germination
GO993_08760	COG4657	Part of a membrane complex involved in electron transport
GO993_08765	COG2878	Part of a membrane complex involved in electron transport
GO993_08780	COG4659	FMN binding
GO993_08790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO993_08795	COG0346	lactoylglutathione lyase activity
GO993_08810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO993_08820	COG3328	transposase activity
GO993_08835	COG0513	Belongs to the DEAD box helicase family
GO993_08840	COG2050	protein possibly involved in aromatic compounds catabolism
GO993_08860	COG1253	flavin adenine dinucleotide binding
GO993_08865	COG1902	pentaerythritol trinitrate reductase activity
GO993_08875	COG0647	UMP catabolic process
GO993_08890	COG0367	asparagine synthase
GO993_08915	COG0625	glutathione transferase activity
GO993_08920	COG0625	glutathione transferase activity
GO993_08945	COG0564	pseudouridine synthase activity
GO993_08975	COG0670	Belongs to the BI1 family
GO993_08980	COG1289	transmembrane transporter activity
GO993_08985	COG2920	part of a sulfur-relay system
GO993_08990	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GO993_09005	COG0101	tRNA pseudouridine synthase activity
GO993_09015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO993_09020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO993_09025	COG0671	phosphoesterase, PA-phosphatase related
GO993_09150	COG0672	)-iron permease
GO993_09175	COG2814	Major facilitator Superfamily
GO993_09210	COG1285	pathogenesis
GO993_09265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO993_09270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO993_09270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO993_09310	COG0393	Putative heavy-metal-binding
GO993_09315	COG1252	NADH dehydrogenase
GO993_09320	COG3150	esterase
GO993_09345	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO993_09350	COG2096	Adenosyltransferase
GO993_09355	COG3530	Putative quorum-sensing-regulated virulence factor
GO993_09360	COG0602	queuosine metabolic process
GO993_09365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO993_09380	COG0284	orotidine-5'-phosphate decarboxylase activity
GO993_09395	COG0776	regulation of translation
GO993_09400	COG0539	negative regulation of cytoplasmic translation
GO993_09405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO993_09410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO993_09420	COG0583	DNA-binding transcription factor activity
GO993_09425	COG2814	Major facilitator Superfamily
GO993_09445	COG3300	MHYT domain
GO993_09445	COG5001	Diguanylate cyclase
GO993_09460	COG0583	DNA-binding transcription factor activity
GO993_09490	COG4989	oxidoreductase activity
GO993_09495	COG0724	RNA recognition motif
GO993_09520	COG1570	exodeoxyribonuclease VII activity
GO993_09535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO993_09540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO993_09545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO993_09565	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GO993_09565	COG0644	oxidoreductase
GO993_09600	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO993_09605	COG1120	ATPase activity
GO993_09610	COG2977	Belongs to the P-Pant transferase superfamily
GO993_09630	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_09640	COG1535	isochorismatase
GO993_09640	COG3433	isochorismatase activity
GO993_09685	COG0840	transmembrane signaling receptor activity
GO993_09700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO993_09705	COG0563	adenylate kinase activity
GO993_09715	COG0326	Molecular chaperone. Has ATPase activity
GO993_09720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO993_09740	COG5433	transposase activity
GO993_09765	COG5433	transposase activity
GO993_09770	COG4221	oxidoreductase activity
GO993_09770	COG3321	synthase
GO993_09770	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_09770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO993_09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO993_09805	COG0217	transcriptional regulatory protein
GO993_09810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO993_09835	COG4106	trans-aconitate 2-methyltransferase activity
GO993_09840	COG0500	methyltransferase
GO993_09860	COG0450	alkyl hydroperoxide reductase
GO993_09865	COG5433	transposase activity
GO993_09875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GO993_09900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO993_09910	COG1684	flagellar biosynthetic protein fliR
GO993_09965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO993_09975	COG1677	Flagellar hook-basal body complex protein FliE
GO993_10000	COG1342	Belongs to the UPF0251 family
GO993_10020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO993_10045	COG1737	Transcriptional regulator
GO993_10050	COG0469	pyruvate kinase activity
GO993_10060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO993_10065	COG1960	acyl-CoA dehydrogenase activity
GO993_10080	COG5433	transposase activity
GO993_10090	COG5433	transposase activity
GO993_10115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO993_10125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO993_10130	COG2261	transglycosylase associated protein
GO993_10175	COG2197	response regulator
GO993_10185	COG2835	tetraacyldisaccharide 4'-kinase activity
GO993_10190	COG1663	tetraacyldisaccharide 4'-kinase activity
GO993_10195	COG1132	(ABC) transporter
GO993_10220	COG1448	Aminotransferase
GO993_10250	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO993_10255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO993_10260	COG1785	Belongs to the alkaline phosphatase family
GO993_10280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO993_10295	COG2271	Major facilitator Superfamily
GO993_10300	COG3706	GGDEF domain
GO993_10310	COG0765	amino acid transport
GO993_10315	COG1126	abc transporter atp-binding protein
GO993_10325	COG0531	amino acid
GO993_10345	COG0704	Plays a role in the regulation of phosphate uptake
GO993_10355	COG0581	inorganic phosphate transmembrane transporter activity
GO993_10360	COG0573	inorganic phosphate transmembrane transporter activity
GO993_10365	COG0590	tRNA wobble adenosine to inosine editing
GO993_10375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO993_10395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO993_10400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO993_10405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO993_10410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO993_10420	COG3852	Histidine kinase
GO993_10440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO993_10445	COG0248	Ppx GppA phosphatase
GO993_10450	COG2239	Acts as a magnesium transporter
GO993_10490	COG0622	Phosphoesterase
GO993_10525	COG0697	spore germination
GO993_10555	COG1278	Cold shock
GO993_10610	COG3132	Protein of unknown function, DUF480
GO993_10620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO993_10650	COG0583	DNA-binding transcription factor activity
GO993_10655	COG2610	gluconate transmembrane transporter activity
GO993_10670	COG0538	isocitrate dehydrogenase activity
GO993_10690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO993_10720	COG5433	transposase activity
GO993_10735	COG1032	radical SAM domain protein
GO993_10750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO993_10755	COG3706	GGDEF domain
GO993_10765	COG0733	neurotransmitter:sodium symporter activity
GO993_10795	COG0281	malic enzyme
GO993_10800	COG2207	Transcriptional regulator
GO993_10820	COG2233	PERMEase
GO993_10825	COG0095	Lipoate-protein ligase
GO993_10830	COG1115	amino acid carrier protein
GO993_10835	COG0019	diaminopimelate decarboxylase activity
GO993_10875	COG1131	(ABC) transporter
GO993_10880	COG0545	Peptidyl-prolyl cis-trans isomerase
GO993_10885	COG3142	Participates in the control of copper homeostasis
GO993_10915	COG0745	RESPONSE REGULATOR receiver
GO993_10920	COG0346	lactoylglutathione lyase activity
GO993_10925	COG3706	GGDEF domain
GO993_10930	COG3284	Transcriptional regulator
GO993_10935	COG1012	belongs to the aldehyde dehydrogenase family
GO993_10940	COG1942	4-Oxalocrotonate Tautomerase
GO993_10975	COG0667	Aldo Keto reductase
GO993_10995	COG0281	malic enzyme
GO993_11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_11095	COG0437	4 iron, 4 sulfur cluster binding
GO993_11145	COG5433	transposase activity
GO993_11165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO993_11210	COG3273	potassium ion transport
GO993_11210	COG0471	metal ion transport
GO993_11230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO993_11255	COG1450	Type ii and iii secretion system protein
GO993_11300	COG1459	type II secretion system
GO993_11305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO993_11325	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO993_11350	COG1309	transcriptional regulator
GO993_11365	COG1946	Acyl-CoA thioesterase
GO993_11375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO993_11385	COG0009	L-threonylcarbamoyladenylate synthase
GO993_11400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO993_11405	COG0512	Glutamine amidotransferase of anthranilate synthase
GO993_11405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO993_11410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO993_11415	COG0134	indole-3-glycerol-phosphate synthase activity
GO993_11415	COG0135	phosphoribosylanthranilate isomerase activity
GO993_11420	COG0133	tryptophan synthase activity
GO993_11425	COG0159	tryptophan synthase activity
GO993_11450	COG1388	LysM domain
GO993_11450	COG1376	ErfK ybiS ycfS ynhG family protein
GO993_11465	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GO993_11470	COG0791	NLP P60 protein
GO993_11475	COG2091	lysine biosynthetic process via aminoadipic acid
GO993_11480	COG3118	belongs to the thioredoxin family
GO993_11490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO993_11495	COG0788	formyltetrahydrofolate deformylase activity
GO993_11525	COG0366	Alpha amylase catalytic
GO993_11530	COG0739	heme binding
GO993_11530	COG0741	lytic transglycosylase activity
GO993_11530	COG1196	nuclear chromosome segregation
GO993_11540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO993_11545	COG0673	inositol 2-dehydrogenase activity
GO993_11575	COG2814	Major facilitator Superfamily
GO993_11580	COG0109	protoheme IX farnesyltransferase activity
GO993_11590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO993_11595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO993_11690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO993_11700	COG0095	Lipoate-protein ligase
GO993_11745	COG1285	pathogenesis
GO993_11775	COG0484	heat shock protein binding
GO993_11780	COG0443	Heat shock 70 kDa protein
GO993_11785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO993_11790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO993_11795	COG0497	DNA recombination
GO993_11805	COG1227	inorganic diphosphatase activity
GO993_11815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO993_11830	COG2375	cellular response to nickel ion
GO993_11835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO993_11850	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO993_11885	COG2169	Transcriptional regulator
GO993_11885	COG1917	Cupin 2, conserved barrel domain protein
GO993_11905	COG1917	Cupin 2, conserved barrel domain protein
GO993_11905	COG1396	sequence-specific DNA binding
GO993_11920	COG0531	amino acid
GO993_11925	COG0531	amino acid
GO993_11930	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO993_11940	COG3384	dioxygenase
GO993_11955	COG0813	purine-nucleoside phosphorylase activity
GO993_11980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO993_11985	COG0083	homoserine kinase activity
GO993_11995	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO993_12000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GO993_12015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO993_12025	COG0745	RESPONSE REGULATOR receiver
GO993_12040	COG4988	ABC transporter
GO993_12045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO993_12065	COG1720	tRNA m6t6A37 methyltransferase activity
GO993_12085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO993_12090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_12100	COG2190	(PTS) system
GO993_12105	COG3706	GGDEF domain
GO993_12115	COG3038	cytochrome b561
GO993_12125	COG0419	ATPase involved in DNA repair
GO993_12130	COG0420	3'-5' exonuclease activity
GO993_12140	COG2974	May be involved in recombination
GO993_12150	COG4651	solute:proton antiporter activity
GO993_12150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO993_12155	COG4651	solute:proton antiporter activity
GO993_12155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO993_12170	COG0469	pyruvate kinase activity
GO993_12175	COG3264	Mechanosensitive ion channel
GO993_12175	COG1196	nuclear chromosome segregation
GO993_12180	COG0582	viral genome integration into host DNA
GO993_12200	COG1846	Transcriptional regulator
GO993_12205	COG1566	PFAM secretion protein HlyD family protein
GO993_12230	COG0602	queuosine metabolic process
GO993_12240	COG1328	CTP reductase activity
GO993_12250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO993_12270	COG2860	membrane
GO993_12280	COG3108	Peptidase M15
GO993_12285	COG2989	Protein conserved in bacteria
GO993_12295	COG5433	transposase activity
GO993_12320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO993_12330	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO993_12335	COG5433	transposase activity
GO993_12365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO993_12375	COG3091	SprT-like family
GO993_12385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO993_12390	COG0189	ligase activity
GO993_12410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO993_12440	COG0714	Associated with various cellular activities
GO993_12455	COG1115	amino acid carrier protein
GO993_12460	COG5433	transposase activity
GO993_12465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO993_12480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO993_12500	COG1301	dicarboxylic acid transport
GO993_12510	COG2912	Transglutaminase-like superfamily
GO993_12520	COG2890	protein-(glutamine-N5) methyltransferase activity
GO993_12525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO993_12530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO993_12535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO993_12540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO993_12550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO993_12555	COG0737	Belongs to the 5'-nucleotidase family
GO993_12560	COG0193	aminoacyl-tRNA hydrolase activity
GO993_12565	COG0012	GTP binding
GO993_12620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GO993_12655	COG0463	Glycosyl transferase, family 2
GO993_12670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO993_12675	COG2076	Multidrug Resistance protein
GO993_12685	COG3954	Phosphoribulokinase
GO993_12700	COG1765	OsmC-like protein
GO993_12740	COG3655	Transcriptional regulator
GO993_12750	COG2814	Major facilitator Superfamily
GO993_12775	COG0748	coenzyme F420 binding
GO993_12780	COG3721	Heme iron utilization protein
GO993_12790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO993_12815	COG0488	(ABC) transporter
GO993_12825	COG2252	PERMEase
GO993_12830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO993_12845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GO993_12855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GO993_12860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO993_12865	COG2967	ApaG domain
GO993_12870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO993_12905	COG0318	PFAM AMP-dependent synthetase and ligase
GO993_12915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO993_12920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO993_12925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO993_12930	COG0142	geranyltranstransferase activity
GO993_12935	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GO993_12940	COG0330	HflC and HflK could
GO993_12950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO993_12955	COG1923	regulation of RNA biosynthetic process
GO993_12960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO993_12975	COG0802	atpase or kinase
GO993_13000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO993_13005	COG2011	ABC-type metal ion transport system permease component
GO993_13010	COG1464	Belongs to the NlpA lipoprotein family
GO993_13095	COG2716	regulation of RNA biosynthetic process
GO993_13100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO993_13105	COG3013	Belongs to the UPF0304 family
GO993_13115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO993_13120	COG0857	belongs to the CobB CobQ family
GO993_13120	COG0280	phosphate acetyltransferase
GO993_13125	COG0440	acetolactate synthase activity
GO993_13145	COG0671	phosphoesterase, PA-phosphatase related
GO993_13155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO993_13160	COG0473	3-isopropylmalate dehydrogenase activity
GO993_13165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO993_13170	COG0066	3-isopropylmalate dehydratase activity
GO993_13185	COG4143	(ABC) transporter
GO993_13190	COG1178	ABC-type Fe3 transport system permease component
GO993_13195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO993_13200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO993_13210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO993_13240	COG0316	Belongs to the HesB IscA family
GO993_13255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO993_13270	COG0671	phosphoesterase, PA-phosphatase related
GO993_13285	COG0583	DNA-binding transcription factor activity
GO993_13290	COG2076	Multidrug Resistance protein
GO993_13300	COG0346	lactoylglutathione lyase activity
GO993_13320	COG1489	DNA binding
GO993_13325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO993_13330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO993_13335	COG0617	tRNA 3'-terminal CCA addition
GO993_13345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO993_13350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO993_13360	COG0842	Transport permease protein
GO993_13365	COG1131	(ABC) transporter
GO993_13380	COG0163	prenyltransferase activity
GO993_13390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO993_13395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO993_13400	COG2816	NAD+ diphosphatase activity
GO993_13405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO993_13405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO993_13405	COG0506	proline dehydrogenase activity
GO993_13410	COG4991	sh3 domain protein
GO993_13415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO993_13435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO993_13440	COG1640	4-alpha-glucanotransferase
GO993_13445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO993_13450	COG0676	glucose-6-phosphate 1-epimerase activity
GO993_13455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO993_13460	COG0840	transmembrane signaling receptor activity
GO993_13525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GO993_13530	COG2885	chlorophyll binding
GO993_13535	COG0823	Involved in the tonB-independent uptake of proteins
GO993_13550	COG0811	peptide transport
GO993_13555	COG0824	Thioesterase
GO993_13560	COG3790	cyd operon protein YbgE
GO993_13565	COG4890	Cyd operon protein YbgT
GO993_13575	COG1271	oxidase subunit
GO993_13585	COG0632	four-way junction helicase activity
GO993_13590	COG0840	transmembrane signaling receptor activity
GO993_13595	COG0442	prolyl-tRNA aminoacylation
GO993_13605	COG1902	pentaerythritol trinitrate reductase activity
GO993_13615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO993_13655	COG0456	acetyltransferase
GO993_13665	COG1022	Amp-dependent synthetase and ligase
GO993_13675	COG2918	glutathione biosynthetic process
GO993_13680	COG0612	Peptidase, M16
GO993_13685	COG1238	metal cluster binding
GO993_13720	COG0359	binds to the 23S rRNA
GO993_13725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO993_13730	COG0360	Binds together with S18 to 16S ribosomal RNA
GO993_13735	COG1914	H( )-stimulated, divalent metal cation uptake system
GO993_13740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO993_13755	COG2153	protein acetylation
GO993_13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO993_13770	COG0557	exoribonuclease II activity
GO993_13775	COG3706	GGDEF domain
GO993_13780	COG1854	S-ribosylhomocysteine lyase activity
GO993_13795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO993_13795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO993_13830	COG4968	Prepilin-type N-terminal cleavage methylation domain
GO993_13835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO993_13840	COG1047	Peptidyl-prolyl cis-trans
GO993_13850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO993_13855	COG0196	riboflavin kinase activity
GO993_13865	COG0268	Binds directly to 16S ribosomal RNA
GO993_13870	COG0640	Transcriptional regulator
GO993_13875	COG0583	DNA-binding transcription factor activity
GO993_13885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO993_13890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO993_13895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO993_13915	COG1051	belongs to the nudix hydrolase family
GO993_13920	COG3066	DNA modification
GO993_13930	COG0335	large ribosomal subunit rRNA binding
GO993_13935	COG0336	Belongs to the RNA methyltransferase TrmD family
GO993_13940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO993_13945	COG0228	four-way junction DNA binding
GO993_13950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO993_13955	COG4137	Cytochrome C assembly protein
GO993_13960	COG4536	flavin adenine dinucleotide binding
GO993_13965	COG1959	2 iron, 2 sulfur cluster binding
GO993_13970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO993_13970	COG1017	nitric oxide dioxygenase activity
GO993_13975	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GO993_13980	COG0039	L-malate dehydrogenase activity
GO993_13985	COG4160	amino acid transport
GO993_13990	COG4215	(ABC) transporter
GO993_13995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_14000	COG1126	abc transporter atp-binding protein
GO993_14005	COG1438	arginine binding
GO993_14010	COG2837	iron assimilation
GO993_14015	COG3842	ATPase activity
GO993_14025	COG1840	ABC-type Fe3 transport system, periplasmic component
GO993_14030	COG0347	Belongs to the P(II) protein family
GO993_14050	COG0004	ammonium transporteR
GO993_14055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO993_14070	COG0084	hydrolase, TatD family'
GO993_14085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO993_14090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO993_14095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO993_14100	COG0813	purine-nucleoside phosphorylase activity
GO993_14110	COG0560	Phosphoserine phosphatase
GO993_14135	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GO993_14145	COG0776	regulation of translation
GO993_14160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO993_14165	COG0735	belongs to the Fur family
GO993_14185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO993_14190	COG0513	Belongs to the DEAD box helicase family
GO993_14195	COG3022	response to hydroperoxide
GO993_14210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO993_14215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO993_14220	COG0762	integral membrane protein
GO993_14225	COG1872	DUF167
GO993_14250	COG0110	maltose O-acetyltransferase activity
GO993_14275	COG4221	oxidoreductase activity
GO993_14285	COG2957	Belongs to the agmatine deiminase family
GO993_14320	COG0347	Belongs to the P(II) protein family
GO993_14345	COG3706	GGDEF domain
GO993_14355	COG1278	Cold shock
GO993_14370	COG2197	response regulator
GO993_14415	COG0513	Belongs to the DEAD box helicase family
GO993_14470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO993_14475	COG1328	CTP reductase activity
GO993_14515	COG1215	transferase activity, transferring glycosyl groups
GO993_14520	COG1649	PFAM Uncharacterised BCR, COG1649
GO993_14520	COG0726	polysaccharide deacetylase
GO993_14565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GO993_14570	COG4208	sulfate ABC transporter
GO993_14575	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GO993_14585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GO993_14600	COG3174	membrane
GO993_14605	COG0110	maltose O-acetyltransferase activity
GO993_14635	COG1942	4-Oxalocrotonate Tautomerase
GO993_14645	COG0583	DNA-binding transcription factor activity
GO993_14650	COG0165	Argininosuccinate lyase
GO993_14690	COG0814	amino acid
GO993_14695	COG3932	Exopolysaccharide synthesis, ExoD
GO993_14755	COG1494	fructose-1,6-bisphosphatase
GO993_14770	COG2959	enzyme of heme biosynthesis
GO993_14780	COG0181	hydroxymethylbilane synthase activity
GO993_14795	COG1965	Belongs to the frataxin family
GO993_14805	COG0019	diaminopimelate decarboxylase activity
GO993_14825	COG1011	Hydrolase
GO993_14845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GO993_14850	COG0561	phosphatase activity
GO993_14865	COG1129	ABC transporter
GO993_14865	COG0842	Transport permease protein
GO993_14875	COG1058	Belongs to the CinA family
GO993_14875	COG1546	Belongs to the CinA family
GO993_14880	COG1418	mRNA catabolic process
GO993_14885	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO993_14895	COG1522	sequence-specific DNA binding
GO993_14900	COG1368	sulfuric ester hydrolase activity
GO993_14940	COG4221	oxidoreductase activity
GO993_14970	COG2873	o-acetylhomoserine
GO993_14980	COG4533	DNA binding
GO993_15000	COG5380	lipid catabolic process
GO993_15005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO993_15020	COG2949	membrane
GO993_15025	COG3291	Pkd domain containing protein
GO993_15060	COG1051	belongs to the nudix hydrolase family
GO993_15065	COG3150	esterase
GO993_15075	COG3151	Protein conserved in bacteria
GO993_15080	COG0494	nUDIX hydrolase
GO993_15085	COG1538	Outer membrane efflux protein
GO993_15090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GO993_15090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO993_15095	COG1560	Kdo2-lipid A biosynthetic process
GO993_15110	COG1392	Phosphate transport regulator
GO993_15115	COG0306	phosphate transporter
GO993_15120	COG0617	tRNA 3'-terminal CCA addition
GO993_15125	COG3409	Peptidoglycan-binding domain 1 protein
GO993_15125	COG3267	Type II secretory pathway component ExeA
GO993_15135	COG1194	a g-specific adenine glycosylase
GO993_15140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GO993_15150	COG3111	PFAM Bacterial OB fold (BOF) protein
GO993_15155	COG3240	lipase activity
GO993_15170	COG3009	Protein conserved in bacteria
GO993_15175	COG3008	intermembrane lipid transfer
GO993_15175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO993_15190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO993_15205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO993_15210	COG2813	Specifically methylates the guanine in position
GO993_15215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO993_15220	COG0297	glycogen (starch) synthase activity
GO993_15255	COG1757	Na H antiporter
GO993_15265	COG0110	maltose O-acetyltransferase activity
GO993_15270	COG0366	Alpha amylase catalytic
GO993_15275	COG1263	PTS System
GO993_15275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO993_15295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO993_15305	COG2723	6-phospho-beta-galactosidase activity
GO993_15310	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO993_15315	COG1940	carbohydrate kinase activity
GO993_15325	COG1609	Transcriptional regulator
GO993_15335	COG0252	asparaginase activity
GO993_15350	COG1803	Methylglyoxal synthase
GO993_15375	COG1444	tRNA N-acetyltransferase activity
GO993_15380	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_15385	COG0784	Response regulator, receiver
GO993_15385	COG0835	chemotaxis
GO993_15425	COG5433	transposase activity
GO993_15430	COG0582	viral genome integration into host DNA
GO993_15445	COG0795	lipopolysaccharide-transporting ATPase activity
GO993_15450	COG0795	lipopolysaccharide-transporting ATPase activity
GO993_15460	COG2927	DNA polymerase III (CHI subunit)
GO993_15480	COG1686	Belongs to the peptidase S11 family
GO993_15505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO993_15510	COG0527	aspartate kinase activity
GO993_15515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO993_15525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO993_15535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO993_15570	COG1380	Effector of murein hydrolase LrgA
GO993_15575	COG1346	cytolysis
GO993_15590	COG0527	aspartate kinase activity
GO993_15590	COG0460	homoserine dehydrogenase
GO993_15610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO993_15615	COG0814	amino acid
GO993_15620	COG1218	3'(2'),5'-bisphosphate nucleotidase
GO993_15625	COG0494	nUDIX hydrolase
GO993_15630	COG1011	Hydrolase
GO993_15635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO993_15650	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO993_15660	COG3156	type II secretion system protein K
GO993_15665	COG4795	General secretion pathway protein
GO993_15670	COG2165	general secretion pathway protein
GO993_15680	COG2165	general secretion pathway protein
GO993_15690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO993_15710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO993_15715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO993_15735	COG0456	acetyltransferase
GO993_15740	COG3133	Outer membrane lipoprotein
GO993_15755	COG2771	luxR family
GO993_15770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GO993_15790	COG0246	Mannitol dehydrogenase
GO993_15795	COG3722	fumarate hydratase activity
GO993_15800	COG3263	regulation of cellular component size
GO993_15805	COG0484	heat shock protein binding
GO993_15825	COG1671	Belongs to the UPF0178 family
GO993_15840	COG1988	membrane-bound metal-dependent
GO993_15845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO993_15865	COG0513	Belongs to the DEAD box helicase family
GO993_15885	COG5433	transposase activity
GO993_15900	COG1575	Belongs to the MenA family. Type 1 subfamily
GO993_15910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO993_15915	COG0596	Alpha beta hydrolase
GO993_15920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO993_15930	COG0318	PFAM AMP-dependent synthetase and ligase
GO993_15955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO993_15975	COG1929	Belongs to the glycerate kinase type-1 family
GO993_15980	COG2610	gluconate transmembrane transporter activity
GO993_15985	COG3835	regulator
GO993_15990	COG3112	Uncharacterised protein family (UPF0231)
GO993_16060	COG2259	Doxx family
GO993_16065	COG3118	belongs to the thioredoxin family
GO993_16085	COG0204	Acyl-transferase
GO993_16105	COG2827	Endonuclease containing a URI domain
GO993_16120	COG1573	uracil-dna glycosylase
GO993_16135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO993_16140	COG1121	(ABC) transporter
GO993_16145	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GO993_16165	COG0739	heme binding
GO993_16175	COG3068	Protein conserved in bacteria
GO993_16215	COG0798	PFAM Bile acid sodium symporter
GO993_16220	COG1393	Belongs to the ArsC family
GO993_16230	COG2072	flavoprotein involved in K transport
GO993_16240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO993_16250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO993_16275	COG5433	transposase activity
GO993_16280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO993_16285	COG1086	Polysaccharide biosynthesis protein
GO993_16290	COG0366	Alpha amylase catalytic
GO993_16310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO993_16315	COG3045	CreA protein
GO993_16350	COG3842	ATPase activity
GO993_16355	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO993_16360	COG1177	transmembrane transport
GO993_16365	COG2258	MOSC domain
GO993_16380	COG2050	protein possibly involved in aromatic compounds catabolism
GO993_16385	COG0514	ATP-dependent DNA helicase (RecQ)
GO993_16395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GO993_16405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO993_16410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO993_16420	COG2239	Acts as a magnesium transporter
GO993_16425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO993_16425	COG1648	precorrin-2 dehydrogenase activity
GO993_16430	COG2116	formate transmembrane transporter activity
GO993_16440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO993_16455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO993_16460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO993_16470	COG0018	arginyl-trna synthetase
GO993_16480	COG1595	DNA-templated transcription, initiation
GO993_16490	COG1968	undecaprenyl-diphosphatase activity
GO993_16495	COG0667	Aldo Keto reductase
GO993_16500	COG2017	converts alpha-aldose to the beta-anomer
GO993_16505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO993_16515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO993_16520	COG1609	Transcriptional regulator
GO993_16525	COG3250	beta-galactosidase activity
GO993_16540	COG4211	Belongs to the binding-protein-dependent transport system permease family
GO993_16565	COG5433	transposase activity
GO993_16595	COG0753	catalase activity
GO993_16600	COG1247	-acetyltransferase
GO993_16620	COG2199	diguanylate cyclase activity
GO993_16620	COG2203	Gaf domain
GO993_16630	COG3842	ATPase activity
GO993_16640	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO993_16665	COG0583	DNA-binding transcription factor activity
GO993_16675	COG1741	Belongs to the pirin family
GO993_16680	COG2259	Doxx family
GO993_16685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO993_16690	COG1074	ATP-dependent DNA helicase activity
GO993_16695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO993_16770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO993_16775	COG0745	RESPONSE REGULATOR receiver
GO993_16780	COG2205	protein histidine kinase activity
GO993_16790	COG0281	malic enzyme
GO993_16800	COG0254	rRNA binding
GO993_16805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO993_16815	COG1309	transcriptional regulator
GO993_16835	COG0129	dihydroxy-acid dehydratase activity
GO993_16845	COG3978	acetolactate synthase activity
GO993_16855	COG0606	chelatase, subunit chli
GO993_16865	COG1683	Conserved Protein
GO993_16875	COG1335	isochorismatase
GO993_16885	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GO993_16890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GO993_16900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO993_16905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO993_16915	COG3084	Protein conserved in bacteria
GO993_16920	COG2203	Gaf domain
GO993_16920	COG5001	Diguanylate cyclase
GO993_16920	COG4251	negative regulation of phosphorylation
GO993_16920	COG3706	GGDEF domain
GO993_16935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO993_16990	COG5433	transposase activity
GO993_17005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO993_17045	COG0210	DNA helicase
GO993_17050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO993_17055	COG2166	iron-sulfur cluster assembly
GO993_17060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO993_17090	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GO993_17095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO993_17100	COG1739	Uncharacterized protein family UPF0029
GO993_17105	COG0006	proline dipeptidase activity
GO993_17110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO993_17120	COG0183	Belongs to the thiolase family
GO993_17125	COG0745	RESPONSE REGULATOR receiver
GO993_17130	COG2205	protein histidine kinase activity
GO993_17145	COG0425	Belongs to the sulfur carrier protein TusA family
GO993_17150	COG0251	oxidation-reduction process
GO993_17155	COG2885	chlorophyll binding
GO993_17160	COG2818	Glycosylase
GO993_17165	COG0752	glycyl-tRNA synthetase alpha subunit
GO993_17170	COG0751	glycine-tRNA ligase activity
GO993_17185	COG3328	transposase activity
GO993_17225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO993_17235	COG2200	EAL domain
GO993_17235	COG2199	diguanylate cyclase activity
GO993_17235	COG2202	Pas domain
GO993_17250	COG0814	amino acid
GO993_17255	COG0348	domain, Protein
GO993_17265	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO993_17270	COG1773	rubredoxin
GO993_17270	COG0426	domain, Protein
GO993_17275	COG3604	Transcriptional regulator
GO993_17280	COG2188	Transcriptional regulator
GO993_17285	COG5433	transposase activity
GO993_17310	COG1609	Transcriptional regulator
GO993_17350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO993_17375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO993_17390	COG3118	belongs to the thioredoxin family
GO993_17395	COG0513	Belongs to the DEAD box helicase family
GO993_17400	COG0248	Ppx GppA phosphatase
GO993_17410	COG0742	ribosomal rna small subunit methyltransferase
GO993_17415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_17435	COG0084	hydrolase, TatD family'
GO993_17440	COG0805	protein transport
GO993_17445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO993_17460	COG3165	ubiquinone biosynthetic process from chorismate
GO993_17470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO993_17475	COG0402	S-adenosylhomocysteine deaminase activity
GO993_17515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GO993_17520	COG0848	biopolymer transport protein
GO993_17525	COG0811	peptide transport
GO993_17530	COG0811	peptide transport
GO993_17540	COG2771	luxR family
GO993_17545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO993_17550	COG1349	DNA-binding transcription factor activity
GO993_17555	COG0745	RESPONSE REGULATOR receiver
GO993_17560	COG2205	protein histidine kinase activity
GO993_17575	COG4452	Inner membrane protein CreD
GO993_17580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO993_17585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO993_17590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO993_17595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO993_17600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO993_17605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO993_17610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO993_17620	COG0356	it plays a direct role in the translocation of protons across the membrane
GO993_17625	COG3312	ion transport
GO993_17630	COG1475	DNA binding
GO993_17635	COG1192	Involved in chromosome partitioning
GO993_17640	COG0357	Ribosomal RNA small subunit methyltransferase G
GO993_17645	COG0445	tRNA wobble uridine modification
GO993_17650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO993_17655	COG4774	siderophore transport
GO993_17660	COG4615	Cyclic peptide transporter
GO993_17665	COG1120	ATPase activity
GO993_17670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO993_17690	COG4604	ABC transporter, ATP-binding protein
GO993_17695	COG4605	iron ion homeostasis
GO993_17700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO993_17720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO993_17745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO993_17750	COG0706	membrane insertase activity
GO993_17755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO993_17760	COG0594	ribonuclease P activity
GO993_17765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO993_17785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO993_17790	COG0592	DNA-directed DNA polymerase activity
GO993_17815	COG2378	regulation of single-species biofilm formation
GO993_17820	COG0071	Belongs to the small heat shock protein (HSP20) family
GO993_17825	COG0071	Belongs to the small heat shock protein (HSP20) family
GO993_17840	COG3977	Valine--pyruvate aminotransferase
GO993_17855	COG2814	Major facilitator Superfamily
GO993_17865	COG0745	RESPONSE REGULATOR receiver
GO993_17870	COG2205	protein histidine kinase activity
GO993_17895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_17895	COG4191	Histidine kinase
GO993_17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO993_17905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO993_17910	COG1309	transcriptional regulator
GO993_17940	COG0561	phosphatase activity
GO993_17955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO993_17960	COG1758	RNA polymerase activity
GO993_17965	COG0194	GDP metabolic process
GO993_17975	COG0859	PFAM glycosyl transferase family 9
GO993_17980	COG3642	lipopolysaccharide core region biosynthetic process
GO993_18020	COG0589	response to stress
GO993_18025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO993_18030	COG3706	GGDEF domain
GO993_18040	COG1528	Iron-storage protein
GO993_18045	COG2081	HI0933 family
GO993_18090	COG5433	transposase activity
GO993_18095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO993_18095	COG2205	protein histidine kinase activity
GO993_18105	COG3275	phosphorelay sensor kinase activity
GO993_18110	COG3279	Response regulator of the LytR AlgR family
GO993_18115	COG2223	nitrite transmembrane transporter activity
GO993_18120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO993_18125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO993_18140	COG0583	DNA-binding transcription factor activity
GO993_18145	COG4206	TonB-dependent receptor
GO993_18150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO993_18180	COG1042	CoA-binding domain protein
GO993_18180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO993_18180	COG0045	succinate-CoA ligase (ADP-forming) activity
GO993_18195	COG0583	DNA-binding transcription factor activity
GO993_18200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO993_18205	COG0166	Belongs to the GPI family
GO993_18215	COG0668	transmembrane transport
GO993_18220	COG1309	transcriptional regulator
GO993_18225	COG0756	dUTP diphosphatase activity
GO993_18235	COG2003	Belongs to the UPF0758 family
GO993_18240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO993_18245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO993_18255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO993_18260	COG2990	Protein conserved in bacteria
GO993_18265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO993_18270	COG0859	PFAM glycosyl transferase family 9
GO993_18275	COG0463	Glycosyl transferase, family 2
GO993_18280	COG0859	PFAM glycosyl transferase family 9
GO993_18300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_18305	COG1609	Transcriptional regulator
GO993_18330	COG1580	Controls the rotational direction of flagella during chemotaxis
GO993_18335	COG3161	chorismate lyase activity
GO993_18345	COG2937	Belongs to the GPAT DAPAT family
GO993_18350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO993_18365	COG0534	Mate efflux family protein
GO993_18370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO993_18375	COG2205	protein histidine kinase activity
GO993_18380	COG0745	RESPONSE REGULATOR receiver
GO993_18390	COG1045	serine acetyltransferase
GO993_18400	COG3074	FtsZ-dependent cytokinesis
GO993_18405	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GO993_18500	COG0583	DNA-binding transcription factor activity
GO993_18525	COG0210	DNA helicase
GO993_18565	COG1280	lysine exporter protein (LysE YggA)
GO993_18570	COG2391	methyltransferase activity
GO993_18575	COG5433	transposase activity
GO993_18635	COG0569	domain protein
GO993_18640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO993_18640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO993_18645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO993_18650	COG0242	peptide deformylase activity
GO993_18655	COG1652	LysM domain
GO993_18680	COG2922	Belongs to the Smg family
GO993_18685	COG0551	DNA topoisomerase type I activity
GO993_18695	COG0009	L-threonylcarbamoyladenylate synthase
GO993_18700	COG0408	coproporphyrinogen oxidase activity
GO993_18705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO993_18735	COG3078	GTPase activator activity
GO993_18745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO993_18750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO993_18755	COG2204	response regulator
GO993_18760	COG3852	Histidine kinase
GO993_18770	COG0174	glutamine synthetase
GO993_18780	COG1295	ribonuclease BN
GO993_18785	COG1490	D-aminoacyl-tRNA deacylase activity
GO993_18810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO993_18815	COG2610	gluconate transmembrane transporter activity
GO993_18820	COG3265	gluconokinase activity
GO993_18830	COG0800	Aldolase
GO993_18835	COG1609	Transcriptional regulator
GO993_18845	COG4942	peptidase
GO993_18850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO993_18855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO993_18860	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO993_18865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO993_18870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO993_18870	COG0316	Belongs to the HesB IscA family
GO993_18875	COG1040	competence protein
GO993_18880	COG0596	Alpha beta hydrolase
GO993_18900	COG2183	response to ionizing radiation
GO993_18905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO993_18910	COG0745	RESPONSE REGULATOR receiver
GO993_18925	COG0051	transcription antitermination factor activity, RNA binding
GO993_18930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO993_18935	COG0088	Forms part of the polypeptide exit tunnel
GO993_18940	COG0089	rRNA binding
GO993_18945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO993_18950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO993_18955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO993_18960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GO993_18965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO993_18970	COG0255	Belongs to the universal ribosomal protein uL29 family
GO993_18975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO993_18980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO993_18985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO993_18990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO993_18995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO993_19000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO993_19005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO993_19010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO993_19015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO993_19020	COG1841	ribosomal large subunit assembly
GO993_19025	COG0200	Binds to the 23S rRNA
GO993_19030	COG0201	protein transport
GO993_19035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO993_19040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO993_19045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO993_19050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO993_19055	COG0202	RNA polymerase activity
GO993_19060	COG0203	ribosomal protein L17
GO993_19105	COG2252	PERMEase
GO993_19110	COG2376	Dihydroxyacetone kinase
GO993_19115	COG1461	Dihydroxyacetone kinase
GO993_19130	COG3284	Transcriptional regulator
GO993_19135	COG0628	permease
GO993_19145	COG5433	transposase activity
GO993_19160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO993_19165	COG1288	antiporter activity
GO993_19170	COG1438	arginine binding
GO993_19175	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO993_19180	COG0540	Belongs to the ATCase OTCase family
GO993_19195	COG0688	phosphatidylethanolamine metabolic process
GO993_19205	COG3040	lipid binding
GO993_19215	COG1979	alcohol dehydrogenase
GO993_19225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO993_19235	COG2964	Protein conserved in bacteria
GO993_19240	COG3681	Belongs to the UPF0597 family
GO993_19255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO993_19260	COG0564	pseudouridine synthase activity
GO993_19270	COG0542	response to heat
GO993_19275	COG2502	aspartate--ammonia ligase
GO993_19280	COG1522	sequence-specific DNA binding
GO993_19290	COG5413	integral membrane protein
GO993_19295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GO993_19295	COG0617	tRNA 3'-terminal CCA addition
GO993_19295	COG0517	IMP dehydrogenase activity
GO993_19300	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_19325	COG2204	response regulator
GO993_19355	COG0745	RESPONSE REGULATOR receiver
GO993_19360	COG2205	protein histidine kinase activity
GO993_19370	COG0243	molybdopterin cofactor binding
GO993_19375	COG3005	denitrification pathway
GO993_19380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO993_19385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO993_19390	COG0569	domain protein
GO993_19395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO993_19420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO993_19435	COG0250	Participates in transcription elongation, termination and antitermination
GO993_19440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GO993_19445	COG0081	regulation of translation
GO993_19450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO993_19455	COG0222	ribosome binding
GO993_19460	COG0085	RNA polymerase activity
GO993_19465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO993_19470	COG2964	Protein conserved in bacteria
GO993_19475	COG0251	oxidation-reduction process
GO993_19485	COG2923	Belongs to the DsrF TusC family
GO993_19490	COG2168	tRNA wobble position uridine thiolation
GO993_19495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO993_19500	COG0049	tRNA binding
GO993_19505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO993_19510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO993_19515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO993_19580	COG3047	cAMP biosynthetic process
GO993_19615	COG1396	sequence-specific DNA binding
GO993_19645	COG2926	Belongs to the UPF0265 family
GO993_19655	COG3028	Belongs to the UPF0307 family
GO993_19660	COG0312	modulator of DNA gyrase
GO993_19665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO993_19670	COG5007	Belongs to the BolA IbaG family
GO993_19680	COG2854	intermembrane phospholipid transfer
GO993_19685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO993_19690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO993_19695	COG1127	ABC transporter
GO993_19700	COG0517	IMP dehydrogenase activity
GO993_19700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO993_19705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO993_19710	COG3117	lipopolysaccharide transmembrane transporter activity
GO993_19715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO993_19720	COG1137	ATPase activity
GO993_19735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_19740	COG1660	Displays ATPase and GTPase activities
GO993_19745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO993_19770	COG3964	amidohydrolase
GO993_19810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO993_19820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO993_19825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO993_19830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO993_19835	COG0723	plastoquinol--plastocyanin reductase activity
GO993_19840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO993_19845	COG2857	Cytochrome c1
GO993_19850	COG0625	glutathione transferase activity
GO993_19855	COG2969	positive regulation of protein catabolic process
GO993_19860	COG2823	Periplasmic or secreted lipoprotein
GO993_19875	COG3107	peptidoglycan biosynthetic process
GO993_19880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO993_19905	COG1987	bacterial-type flagellum assembly
GO993_19930	COG1677	Flagellar hook-basal body complex protein FliE
GO993_19940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO993_19970	COG2747	anti-sigma28 factor FlgM
GO993_19980	COG1815	bacterial-type flagellum-dependent cell motility
GO993_19990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO993_19995	COG1749	Flagellar hook protein flgE
GO993_20005	COG4786	Flagellar basal body rod
GO993_20010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO993_20015	COG1706	bacterial-type flagellum-dependent cell motility
GO993_20025	COG4786	Flagellar basal body rod
GO993_20025	COG1256	bacterial-type flagellum assembly
GO993_20055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO993_20085	COG1191	sigma factor activity
GO993_20090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO993_20115	COG0275	rRNA processing
GO993_20120	COG3116	cell division
GO993_20135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO993_20145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO993_20150	COG0772	Belongs to the SEDS family
GO993_20155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO993_20160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO993_20165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO993_20170	COG0849	cell division
GO993_20175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO993_20180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO993_20190	COG0653	protein targeting
GO993_20200	COG0494	nUDIX hydrolase
GO993_20205	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO993_20210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GO993_20220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GO993_20260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GO993_20265	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO993_20270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO993_20275	COG3447	MASE1 domain protein
GO993_20275	COG5001	Diguanylate cyclase
GO993_20275	COG5002	protein histidine kinase activity
GO993_20285	COG0840	transmembrane signaling receptor activity
GO993_20290	COG0840	transmembrane signaling receptor activity
GO993_20310	COG5433	transposase activity
GO993_20340	COG0583	DNA-binding transcription factor activity
GO993_20350	COG1280	lysine exporter protein (LysE YggA)
GO993_20360	COG0523	cobalamin synthesis protein
GO993_20390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO993_20395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO993_20495	COG0189	ligase activity
GO993_20500	COG0642	Histidine kinase
GO993_20505	COG0745	RESPONSE REGULATOR receiver
GO993_20545	COG1639	'signal transduction protein
GO993_20555	COG3700	Belongs to the class B bacterial acid phosphatase family
GO993_20565	COG1366	Belongs to the anti-sigma-factor antagonist family
GO993_20575	COG0784	Response regulator, receiver
GO993_20575	COG2205	protein histidine kinase activity
GO993_20575	COG5002	protein histidine kinase activity
GO993_20580	COG3437	response regulator, receiver
GO993_20605	COG0312	modulator of DNA gyrase
GO993_20610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO993_20620	COG3164	Protein of unknown function
GO993_20625	COG1530	ribonuclease E activity
GO993_20630	COG0424	maF-like protein
GO993_20635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO993_20640	COG1792	Involved in formation and maintenance of cell shape
GO993_20645	COG1077	Cell shape determining protein MreB Mrl
GO993_20700	COG2200	EAL domain
GO993_20700	COG2199	diguanylate cyclase activity
GO993_20705	COG2264	protein methyltransferase activity
GO993_20715	COG2986	histidine ammonia-lyase
GO993_20720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GO993_20725	COG0010	Belongs to the arginase family
GO993_20730	COG1228	amidohydrolase
GO993_20740	COG0288	reversible hydration of carbon dioxide
GO993_20750	COG2177	Part of the ABC transporter FtsEX involved in
GO993_20760	COG0552	protein localization to endoplasmic reticulum
GO993_20765	COG0742	ribosomal rna small subunit methyltransferase
GO993_20795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO993_20805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO993_20815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO993_20825	COG2095	MarC family integral membrane protein
GO993_20835	COG1301	dicarboxylic acid transport
GO993_20880	COG1770	oligopeptidase
GO993_20895	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO993_20950	COG0513	Belongs to the DEAD box helicase family
GO993_20970	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GO993_21030	COG2816	NAD+ diphosphatase activity
GO993_21045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO993_21070	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_21075	COG5433	transposase activity
GO993_21090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO993_21115	COG5433	transposase activity
GO993_21120	COG1028	Short-chain dehydrogenase reductase Sdr
GO993_21140	COG1349	DNA-binding transcription factor activity
GO993_21145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO993_21175	COG2130	NADP-dependent
GO993_21180	COG1764	response to oxidative stress
GO993_21185	COG1846	Transcriptional regulator
GO993_21215	COG0561	phosphatase activity
GO993_21230	COG0733	neurotransmitter:sodium symporter activity
GO993_21240	COG0733	neurotransmitter:sodium symporter activity
GO993_21265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO993_21280	COG1794	racemase activity, acting on amino acids and derivatives
GO993_21290	COG2731	YhcH YjgK YiaL family protein
GO993_21310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO993_21320	COG0789	Transcriptional regulator
GO993_21325	COG5433	transposase activity
GO993_21340	COG5433	transposase activity
GO993_21400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO993_21410	COG0488	(ABC) transporter
GO993_21415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO993_21415	COG0517	IMP dehydrogenase activity
GO993_21425	COG0330	HflC and HflK could
GO993_21435	COG0175	sulfate reduction
GO993_21440	COG2895	sulfate adenylyltransferase (ATP) activity
GO993_21445	COG0471	metal ion transport
GO993_21445	COG3273	potassium ion transport
GO993_21450	COG0529	Catalyzes the synthesis of activated sulfate
GO993_21470	COG3328	transposase activity
GO993_21475	COG5433	transposase activity
GO993_21510	COG0840	transmembrane signaling receptor activity
GO993_21530	COG1136	(ABC) transporter
GO993_21545	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GO993_21560	COG1940	carbohydrate kinase activity
GO993_21570	COG0126	phosphoglycerate kinase activity
GO993_21575	COG0191	fructose-bisphosphate aldolase activity
GO993_21635	COG1595	DNA-templated transcription, initiation
GO993_21640	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GO993_21655	COG0481	GTPase activity
GO993_21665	COG0571	ribonuclease III activity
GO993_21675	COG1381	Involved in DNA repair and RecF pathway recombination
GO993_21680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO993_21685	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO993_21690	COG4807	Protein conserved in bacteria
GO993_21700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO993_21705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO993_21710	COG3956	TIGRFAM MazG family protein
GO993_21715	COG0504	CTP synthase activity
GO993_21720	COG0148	phosphopyruvate hydratase activity
GO993_21725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO993_21730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO993_21740	COG0585	pseudouridine synthase activity
GO993_21750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO993_21755	COG1238	metal cluster binding
GO993_21760	COG4942	peptidase
GO993_21760	COG1388	LysM domain
GO993_21770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO993_21775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO993_21780	COG1610	YqeY-like protein
GO993_21785	COG0358	DNA primase activity
GO993_21790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO993_21800	COG5433	transposase activity
GO993_21835	COG0151	Belongs to the GarS family
GO993_21840	COG0138	bifunctional purine biosynthesis protein purh
GO993_21855	COG3036	rescue of stalled ribosome
GO993_21860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO993_21865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO993_21890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO993_21920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO993_21925	COG1027	Aspartate ammonia-lyase
GO993_21930	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO993_21935	COG0534	Mate efflux family protein
GO993_21940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO993_21945	COG0459	protein refolding
GO993_21955	COG5001	Diguanylate cyclase
GO993_21955	COG3300	MHYT domain
GO993_21965	COG0564	pseudouridine synthase activity
GO993_21970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO993_21995	COG1280	lysine exporter protein (LysE YggA)
GO993_22000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GO993_22015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO993_22045	COG0745	RESPONSE REGULATOR receiver
GO993_22050	COG3104	oligopeptide transport
GO993_22055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO993_22060	COG1555	photosystem II stabilization
GO993_22070	COG2350	Protein conserved in bacteria
GO993_22075	COG2917	probably involved in intracellular septation
GO993_22080	COG0076	glutamate decarboxylase activity
GO993_22085	COG1272	protein, Hemolysin III
GO993_22090	COG0569	domain protein
GO993_22090	COG2985	domain, Protein
GO993_22115	COG2755	lipolytic protein G-D-S-L family
GO993_22135	COG2200	EAL domain
GO993_22145	COG2234	aminopeptidase activity
GO993_22145	COG4935	Belongs to the peptidase S8 family
GO993_22150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO993_22155	COG3171	Protein conserved in bacteria
GO993_22165	COG2897	thiosulfate sulfurtransferase activity
GO993_22175	COG1132	(ABC) transporter
GO993_22185	COG1012	belongs to the aldehyde dehydrogenase family
GO993_22220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GO993_22225	COG5001	Diguanylate cyclase
GO993_22225	COG3300	MHYT domain
GO993_22245	COG4628	conserved protein (DUF2132)
GO993_22250	COG0688	phosphatidylethanolamine metabolic process
GO993_22260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GO993_22290	COG1278	Cold shock
GO993_22305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO993_22425	COG2336	PFAM SpoVT AbrB
GO993_22570	COG4794	Type iii secretion
GO993_22575	COG4790	Type iii secretion
GO993_22650	COG0457	Tetratricopeptide repeat
GO993_22740	COG1317	bacterial-type flagellum organization
GO993_22790	COG1192	Involved in chromosome partitioning
GO993_22800	COG2916	Histone family protein nucleoid-structuring protein H-NS