locus-tag	class	description
E3D14_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3D14_00010	COG0592	DNA-directed DNA polymerase activity
E3D14_00020	COG0187	DNA topoisomerase II activity
E3D14_00035	COG2378	regulation of single-species biofilm formation
E3D14_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
E3D14_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
E3D14_00060	COG3977	Valine--pyruvate aminotransferase
E3D14_00085	COG0745	RESPONSE REGULATOR receiver
E3D14_00090	COG2205	protein histidine kinase activity
E3D14_00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3D14_00120	COG4191	Histidine kinase
E3D14_00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D14_00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_00135	COG1309	transcriptional regulator
E3D14_00165	COG0561	phosphatase activity
E3D14_00170	COG2267	carboxylic ester hydrolase activity
E3D14_00175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3D14_00180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3D14_00185	COG1758	RNA polymerase activity
E3D14_00190	COG0194	GDP metabolic process
E3D14_00200	COG0859	PFAM glycosyl transferase family 9
E3D14_00205	COG3642	lipopolysaccharide core region biosynthetic process
E3D14_00245	COG0589	response to stress
E3D14_00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3D14_00260	COG1528	Iron-storage protein
E3D14_00265	COG2081	HI0933 family
E3D14_00305	COG4584	PFAM Integrase catalytic
E3D14_00310	COG1484	DNA-dependent DNA replication
E3D14_00325	COG2197	response regulator
E3D14_00330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_00330	COG2205	protein histidine kinase activity
E3D14_00340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_00340	COG2205	protein histidine kinase activity
E3D14_00350	COG3275	phosphorelay sensor kinase activity
E3D14_00355	COG3279	Response regulator of the LytR AlgR family
E3D14_00360	COG2223	nitrite transmembrane transporter activity
E3D14_00365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3D14_00370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3D14_00385	COG0583	DNA-binding transcription factor activity
E3D14_00390	COG4206	TonB-dependent receptor
E3D14_00395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3D14_00440	COG0583	DNA-binding transcription factor activity
E3D14_00445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3D14_00450	COG0166	Belongs to the GPI family
E3D14_00465	COG0668	transmembrane transport
E3D14_00470	COG1309	transcriptional regulator
E3D14_00475	COG0756	dUTP diphosphatase activity
E3D14_00480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3D14_00485	COG2003	Belongs to the UPF0758 family
E3D14_00490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3D14_00495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3D14_00505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3D14_00510	COG2990	Protein conserved in bacteria
E3D14_00515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3D14_00520	COG0859	PFAM glycosyl transferase family 9
E3D14_00525	COG0463	Glycosyl transferase, family 2
E3D14_00530	COG0859	PFAM glycosyl transferase family 9
E3D14_00535	COG1519	Transferase
E3D14_00550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_00555	COG1609	Transcriptional regulator
E3D14_00580	COG1580	Controls the rotational direction of flagella during chemotaxis
E3D14_00585	COG3161	chorismate lyase activity
E3D14_00590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3D14_00595	COG2937	Belongs to the GPAT DAPAT family
E3D14_00600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3D14_00620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3D14_00625	COG2205	protein histidine kinase activity
E3D14_00630	COG0745	RESPONSE REGULATOR receiver
E3D14_00640	COG1045	serine acetyltransferase
E3D14_00650	COG3074	FtsZ-dependent cytokinesis
E3D14_00655	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3D14_00670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3D14_00715	COG0385	Bile acid
E3D14_00720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3D14_00740	COG0583	DNA-binding transcription factor activity
E3D14_00765	COG0210	DNA helicase
E3D14_00800	COG2823	Periplasmic or secreted lipoprotein
E3D14_00820	COG0583	DNA-binding transcription factor activity
E3D14_00825	COG1280	lysine exporter protein (LysE YggA)
E3D14_00830	COG2391	methyltransferase activity
E3D14_00840	COG1280	lysine exporter protein (LysE YggA)
E3D14_00850	COG2962	Rard protein
E3D14_00860	COG1012	belongs to the aldehyde dehydrogenase family
E3D14_00880	COG0519	Catalyzes the synthesis of GMP from XMP
E3D14_00880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3D14_00885	COG0686	Belongs to the AlaDH PNT family
E3D14_00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3D14_00910	COG1322	Protein conserved in bacteria
E3D14_00915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3D14_00920	COG0569	domain protein
E3D14_00925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3D14_00925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3D14_00930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3D14_00935	COG0242	peptide deformylase activity
E3D14_00940	COG1652	LysM domain
E3D14_00945	COG0758	DNA mediated transformation
E3D14_00950	COG2922	Belongs to the Smg family
E3D14_00955	COG0551	DNA topoisomerase type I activity
E3D14_00965	COG0009	L-threonylcarbamoyladenylate synthase
E3D14_00970	COG0408	coproporphyrinogen oxidase activity
E3D14_00975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3D14_00985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3D14_00995	COG3078	GTPase activator activity
E3D14_01005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3D14_01010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3D14_01015	COG2204	response regulator
E3D14_01020	COG3852	Histidine kinase
E3D14_01030	COG0174	glutamine synthetase
E3D14_01040	COG1295	ribonuclease BN
E3D14_01055	COG0456	acetyltransferase
E3D14_01065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3D14_01070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3D14_01075	COG2610	gluconate transmembrane transporter activity
E3D14_01080	COG3265	gluconokinase activity
E3D14_01085	COG0129	dihydroxy-acid dehydratase activity
E3D14_01090	COG0800	Aldolase
E3D14_01105	COG4942	peptidase
E3D14_01110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3D14_01115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3D14_01120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3D14_01125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3D14_01130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3D14_01130	COG0316	Belongs to the HesB IscA family
E3D14_01135	COG1040	competence protein
E3D14_01140	COG0596	Alpha beta hydrolase
E3D14_01160	COG2183	response to ionizing radiation
E3D14_01165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3D14_01170	COG0745	RESPONSE REGULATOR receiver
E3D14_01185	COG0051	transcription antitermination factor activity, RNA binding
E3D14_01190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3D14_01195	COG0088	Forms part of the polypeptide exit tunnel
E3D14_01200	COG0089	rRNA binding
E3D14_01205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3D14_01210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3D14_01215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3D14_01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3D14_01225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3D14_01230	COG0255	Belongs to the universal ribosomal protein uL29 family
E3D14_01235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3D14_01240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3D14_01245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3D14_01250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3D14_01255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3D14_01260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3D14_01265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3D14_01270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3D14_01275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3D14_01280	COG1841	ribosomal large subunit assembly
E3D14_01285	COG0200	Binds to the 23S rRNA
E3D14_01290	COG0201	protein transport
E3D14_01295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3D14_01300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3D14_01305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3D14_01310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3D14_01315	COG0202	RNA polymerase activity
E3D14_01320	COG0203	ribosomal protein L17
E3D14_01365	COG1484	DNA-dependent DNA replication
E3D14_01370	COG4584	PFAM Integrase catalytic
E3D14_01380	COG2376	Dihydroxyacetone kinase
E3D14_01385	COG1461	Dihydroxyacetone kinase
E3D14_01390	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3D14_01390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_01390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3D14_01400	COG3284	Transcriptional regulator
E3D14_01405	COG0628	permease
E3D14_01410	COG0494	nUDIX hydrolase
E3D14_01435	COG0753	catalase activity
E3D14_01460	COG2199	diguanylate cyclase activity
E3D14_01460	COG2203	Gaf domain
E3D14_01470	COG3842	ATPase activity
E3D14_01480	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3D14_01515	COG1741	Belongs to the pirin family
E3D14_01520	COG2259	Doxx family
E3D14_01525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3D14_01530	COG1074	ATP-dependent DNA helicase activity
E3D14_01535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3D14_01545	COG0346	lactoylglutathione lyase activity
E3D14_01560	COG0004	ammonium transporteR
E3D14_01565	COG0347	Belongs to the P(II) protein family
E3D14_01570	COG3706	GGDEF domain
E3D14_01570	COG0745	RESPONSE REGULATOR receiver
E3D14_01580	COG0840	transmembrane signaling receptor activity
E3D14_01600	COG0745	RESPONSE REGULATOR receiver
E3D14_01605	COG2205	protein histidine kinase activity
E3D14_01610	COG3706	GGDEF domain
E3D14_01620	COG1278	Cold shock
E3D14_01630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3D14_01635	COG2197	response regulator
E3D14_01655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3D14_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3D14_01705	COG1770	oligopeptidase
E3D14_01730	COG3714	YhhN family
E3D14_01755	COG1301	dicarboxylic acid transport
E3D14_01765	COG2095	MarC family integral membrane protein
E3D14_01775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3D14_01785	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3D14_01790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3D14_01820	COG0742	ribosomal rna small subunit methyltransferase
E3D14_01825	COG0552	protein localization to endoplasmic reticulum
E3D14_01830	COG2884	Cell division ATP-binding protein ftsE
E3D14_01835	COG2177	Part of the ABC transporter FtsEX involved in
E3D14_01845	COG0288	reversible hydration of carbon dioxide
E3D14_01850	COG2188	Transcriptional regulator
E3D14_01855	COG1228	amidohydrolase
E3D14_01860	COG0010	Belongs to the arginase family
E3D14_01865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E3D14_01870	COG2986	histidine ammonia-lyase
E3D14_01875	COG0387	Pfam Sodium calcium exchanger
E3D14_01885	COG2200	EAL domain
E3D14_01885	COG2199	diguanylate cyclase activity
E3D14_01945	COG1077	Cell shape determining protein MreB Mrl
E3D14_01950	COG1792	Involved in formation and maintenance of cell shape
E3D14_01955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3D14_01960	COG0424	maF-like protein
E3D14_01965	COG1530	ribonuclease E activity
E3D14_01970	COG3164	Protein of unknown function
E3D14_01980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3D14_01985	COG0312	modulator of DNA gyrase
E3D14_02010	COG3437	response regulator, receiver
E3D14_02015	COG5002	protein histidine kinase activity
E3D14_02015	COG2205	protein histidine kinase activity
E3D14_02015	COG0784	Response regulator, receiver
E3D14_02020	COG2172	sigma factor antagonist activity
E3D14_02025	COG1366	Belongs to the anti-sigma-factor antagonist family
E3D14_02035	COG3700	Belongs to the class B bacterial acid phosphatase family
E3D14_02045	COG1639	'signal transduction protein
E3D14_02070	COG0189	ligase activity
E3D14_02080	COG0745	RESPONSE REGULATOR receiver
E3D14_02100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E3D14_02105	COG0352	thiamine-phosphate diphosphorylase activity
E3D14_02110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3D14_02120	COG2022	thiamine diphosphate biosynthetic process
E3D14_02165	COG0110	maltose O-acetyltransferase activity
E3D14_02170	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E3D14_02185	COG0814	amino acid
E3D14_02190	COG3932	Exopolysaccharide synthesis, ExoD
E3D14_02240	COG1494	fructose-1,6-bisphosphatase
E3D14_02255	COG2959	enzyme of heme biosynthesis
E3D14_02265	COG0181	hydroxymethylbilane synthase activity
E3D14_02270	COG3072	Adenylate cyclase
E3D14_02290	COG1965	Belongs to the frataxin family
E3D14_02300	COG0019	diaminopimelate decarboxylase activity
E3D14_02305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3D14_02320	COG1011	Hydrolase
E3D14_02330	COG0668	transmembrane transport
E3D14_02340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3D14_02345	COG0561	phosphatase activity
E3D14_02360	COG1129	ABC transporter
E3D14_02360	COG0842	Transport permease protein
E3D14_02370	COG1546	Belongs to the CinA family
E3D14_02370	COG1058	Belongs to the CinA family
E3D14_02375	COG1418	mRNA catabolic process
E3D14_02380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E3D14_02390	COG1522	sequence-specific DNA binding
E3D14_02395	COG1368	sulfuric ester hydrolase activity
E3D14_02415	COG1285	pathogenesis
E3D14_02435	COG4221	oxidoreductase activity
E3D14_02455	COG1979	alcohol dehydrogenase
E3D14_02465	COG2873	o-acetylhomoserine
E3D14_02475	COG4533	DNA binding
E3D14_02480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E3D14_02495	COG5380	lipid catabolic process
E3D14_02500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3D14_02515	COG2949	membrane
E3D14_02520	COG3291	Pkd domain containing protein
E3D14_02530	COG3539	Fimbrial protein
E3D14_02540	COG3188	usher protein
E3D14_02545	COG3121	Chaperone
E3D14_02550	COG3539	Fimbrial protein
E3D14_02565	COG0318	PFAM AMP-dependent synthetase and ligase
E3D14_02575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3D14_02580	COG0596	Alpha beta hydrolase
E3D14_02585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E3D14_02590	COG1169	isochorismate synthase
E3D14_02595	COG1575	Belongs to the MenA family. Type 1 subfamily
E3D14_02620	COG0513	Belongs to the DEAD box helicase family
E3D14_02625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3D14_02630	COG1988	membrane-bound metal-dependent
E3D14_02645	COG1671	Belongs to the UPF0178 family
E3D14_02665	COG0484	heat shock protein binding
E3D14_02670	COG3263	regulation of cellular component size
E3D14_02675	COG3722	fumarate hydratase activity
E3D14_02680	COG0246	Mannitol dehydrogenase
E3D14_02685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_02685	COG2213	PTS system mannitol-specific
E3D14_02700	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E3D14_02715	COG2771	luxR family
E3D14_02730	COG3133	Outer membrane lipoprotein
E3D14_02735	COG0456	acetyltransferase
E3D14_02755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E3D14_02760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3D14_02780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3D14_02785	COG1459	type II secretion system
E3D14_02790	COG2165	general secretion pathway protein
E3D14_02800	COG2165	general secretion pathway protein
E3D14_02805	COG4795	General secretion pathway protein
E3D14_02810	COG3156	type II secretion system protein K
E3D14_02820	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E3D14_02835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3D14_02840	COG1011	Hydrolase
E3D14_02845	COG0494	nUDIX hydrolase
E3D14_02850	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3D14_02855	COG0814	amino acid
E3D14_02860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D14_02875	COG0626	cystathionine gamma-synthase activity
E3D14_02880	COG0527	aspartate kinase activity
E3D14_02880	COG0460	homoserine dehydrogenase
E3D14_02895	COG1346	cytolysis
E3D14_02900	COG1380	Effector of murein hydrolase LrgA
E3D14_02935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3D14_02940	COG1546	Belongs to the CinA family
E3D14_02945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3D14_02955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3D14_02960	COG0527	aspartate kinase activity
E3D14_02965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3D14_02990	COG1686	Belongs to the peptidase S11 family
E3D14_02995	COG0586	Pfam SNARE associated Golgi protein
E3D14_03000	COG1253	flavin adenine dinucleotide binding
E3D14_03010	COG2927	DNA polymerase III (CHI subunit)
E3D14_03015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3D14_03020	COG0795	lipopolysaccharide-transporting ATPase activity
E3D14_03025	COG0795	lipopolysaccharide-transporting ATPase activity
E3D14_03165	COG4695	Portal protein
E3D14_03250	COG2932	Transcriptional regulator
E3D14_03255	COG4974	Belongs to the 'phage' integrase family
E3D14_03260	COG0582	viral genome integration into host DNA
E3D14_03280	COG3561	AntA/AntB antirepressor
E3D14_03330	COG0004	ammonium transporteR
E3D14_03335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3D14_03355	COG0084	hydrolase, TatD family'
E3D14_03360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3D14_03370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E3D14_03375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E3D14_03380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E3D14_03385	COG0813	purine-nucleoside phosphorylase activity
E3D14_03395	COG0560	Phosphoserine phosphatase
E3D14_03420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E3D14_03425	COG0776	regulation of translation
E3D14_03440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3D14_03445	COG0735	belongs to the Fur family
E3D14_03465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3D14_03470	COG0513	Belongs to the DEAD box helicase family
E3D14_03475	COG3022	response to hydroperoxide
E3D14_03490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3D14_03495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3D14_03500	COG0762	integral membrane protein
E3D14_03505	COG1872	DUF167
E3D14_03520	COG4166	transmembrane transport
E3D14_03530	COG0110	maltose O-acetyltransferase activity
E3D14_03540	COG1024	Enoyl-CoA hydratase
E3D14_03555	COG4221	oxidoreductase activity
E3D14_03565	COG2957	Belongs to the agmatine deiminase family
E3D14_03600	COG0513	Belongs to the DEAD box helicase family
E3D14_03620	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E3D14_03680	COG2816	NAD+ diphosphatase activity
E3D14_03685	COG2205	protein histidine kinase activity
E3D14_03690	COG0745	RESPONSE REGULATOR receiver
E3D14_03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_03700	COG0577	efflux transmembrane transporter activity
E3D14_03700	COG1136	(ABC) transporter
E3D14_03705	COG1505	serine-type exopeptidase activity
E3D14_03710	COG2982	Protein involved in outer membrane biogenesis
E3D14_03735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3D14_03740	COG3730	PTS system glucitol sorbitol-specific
E3D14_03755	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_03765	COG1349	DNA-binding transcription factor activity
E3D14_03770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3D14_03785	COG0494	nUDIX hydrolase
E3D14_03790	COG2130	NADP-dependent
E3D14_03795	COG1764	response to oxidative stress
E3D14_03800	COG1846	Transcriptional regulator
E3D14_03835	COG0561	phosphatase activity
E3D14_03850	COG0733	neurotransmitter:sodium symporter activity
E3D14_03860	COG0733	neurotransmitter:sodium symporter activity
E3D14_03900	COG1794	racemase activity, acting on amino acids and derivatives
E3D14_03910	COG2731	YhcH YjgK YiaL family protein
E3D14_03920	COG0668	transmembrane transport
E3D14_03925	COG1376	ErfK ybiS ycfS ynhG family protein
E3D14_03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3D14_03940	COG0789	Transcriptional regulator
E3D14_04010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3D14_04020	COG0488	(ABC) transporter
E3D14_04025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3D14_04025	COG0517	IMP dehydrogenase activity
E3D14_04030	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3D14_04035	COG0330	HflC and HflK could
E3D14_04040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3D14_04040	COG1648	precorrin-2 dehydrogenase activity
E3D14_04045	COG0175	sulfate reduction
E3D14_04050	COG2895	sulfate adenylyltransferase (ATP) activity
E3D14_04055	COG3273	potassium ion transport
E3D14_04055	COG0471	metal ion transport
E3D14_04060	COG0529	Catalyzes the synthesis of activated sulfate
E3D14_04075	COG0840	transmembrane signaling receptor activity
E3D14_04110	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3D14_04130	COG1940	carbohydrate kinase activity
E3D14_04135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3D14_04140	COG0126	phosphoglycerate kinase activity
E3D14_04145	COG0191	fructose-bisphosphate aldolase activity
E3D14_04150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3D14_04200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3D14_04205	COG1595	DNA-templated transcription, initiation
E3D14_04210	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E3D14_04225	COG0481	GTPase activity
E3D14_04230	COG0681	Belongs to the peptidase S26 family
E3D14_04235	COG0571	ribonuclease III activity
E3D14_04245	COG1381	Involved in DNA repair and RecF pathway recombination
E3D14_04250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3D14_04255	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3D14_04260	COG4807	Protein conserved in bacteria
E3D14_04270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3D14_04275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3D14_04280	COG3956	TIGRFAM MazG family protein
E3D14_04285	COG0504	CTP synthase activity
E3D14_04290	COG0148	phosphopyruvate hydratase activity
E3D14_04295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3D14_04300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3D14_04310	COG0585	pseudouridine synthase activity
E3D14_04315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E3D14_04320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3D14_04325	COG1238	metal cluster binding
E3D14_04330	COG4942	peptidase
E3D14_04330	COG1388	LysM domain
E3D14_04340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3D14_04345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3D14_04350	COG1610	YqeY-like protein
E3D14_04355	COG0358	DNA primase activity
E3D14_04360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3D14_04405	COG0151	Belongs to the GarS family
E3D14_04410	COG0138	bifunctional purine biosynthesis protein purh
E3D14_04420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3D14_04425	COG3036	rescue of stalled ribosome
E3D14_04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3D14_04435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3D14_04460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3D14_04465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3D14_04480	COG0477	Major facilitator Superfamily
E3D14_04490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3D14_04495	COG1027	Aspartate ammonia-lyase
E3D14_04500	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3D14_04510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3D14_04515	COG0459	protein refolding
E3D14_04525	COG5001	Diguanylate cyclase
E3D14_04525	COG3300	MHYT domain
E3D14_04535	COG0564	pseudouridine synthase activity
E3D14_04540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3D14_04570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D14_04580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E3D14_04585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E3D14_04590	COG1178	ABC-type Fe3 transport system permease component
E3D14_04595	COG4143	(ABC) transporter
E3D14_04610	COG0066	3-isopropylmalate dehydratase activity
E3D14_04615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3D14_04620	COG0473	3-isopropylmalate dehydrogenase activity
E3D14_04625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3D14_04635	COG0671	phosphoesterase, PA-phosphatase related
E3D14_04650	COG0028	Belongs to the TPP enzyme family
E3D14_04655	COG0440	acetolactate synthase activity
E3D14_04660	COG0857	belongs to the CobB CobQ family
E3D14_04660	COG0280	phosphate acetyltransferase
E3D14_04665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3D14_04670	COG3092	negative regulation of chromosome organization
E3D14_04675	COG3013	Belongs to the UPF0304 family
E3D14_04680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3D14_04685	COG2716	regulation of RNA biosynthetic process
E3D14_04695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3D14_04700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3D14_04735	COG0784	Response regulator, receiver
E3D14_04735	COG2198	Histidine kinase
E3D14_04735	COG5002	protein histidine kinase activity
E3D14_04760	COG0840	transmembrane signaling receptor activity
E3D14_04770	COG1464	Belongs to the NlpA lipoprotein family
E3D14_04775	COG2011	ABC-type metal ion transport system permease component
E3D14_04805	COG0802	atpase or kinase
E3D14_04815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3D14_04820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3D14_04825	COG1923	regulation of RNA biosynthetic process
E3D14_04830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3D14_04835	COG0330	HflC and HflK could
E3D14_04840	COG0330	HflC and HflK could
E3D14_04845	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E3D14_04850	COG0142	geranyltranstransferase activity
E3D14_04855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3D14_04860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3D14_04865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3D14_04885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E3D14_04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3D14_04910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3D14_04920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3D14_04925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3D14_04935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3D14_04940	COG3178	'Phosphotransferase
E3D14_04945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3D14_04950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3D14_04965	COG0488	(ABC) transporter
E3D14_04990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D14_05000	COG3721	Heme iron utilization protein
E3D14_05005	COG0748	coenzyme F420 binding
E3D14_05025	COG4771	TonB-dependent receptor
E3D14_05030	COG2814	Major facilitator Superfamily
E3D14_05040	COG3655	Transcriptional regulator
E3D14_05065	COG3397	chitin binding
E3D14_05075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3D14_05080	COG1765	OsmC-like protein
E3D14_05095	COG3954	Phosphoribulokinase
E3D14_05100	COG2076	Multidrug Resistance protein
E3D14_05105	COG2076	Multidrug Resistance protein
E3D14_05110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3D14_05115	COG0726	polysaccharide deacetylase
E3D14_05125	COG0463	Glycosyl transferase, family 2
E3D14_05130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3D14_05140	COG3089	Belongs to the UPF0270 family
E3D14_05145	COG5001	Diguanylate cyclase
E3D14_05145	COG4251	negative regulation of phosphorylation
E3D14_05145	COG3706	GGDEF domain
E3D14_05145	COG2203	Gaf domain
E3D14_05150	COG0429	hydrolase of the alpha beta-hydrolase fold
E3D14_05155	COG0835	chemotaxis
E3D14_05155	COG0784	Response regulator, receiver
E3D14_05165	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3D14_05170	COG1047	Peptidyl-prolyl cis-trans
E3D14_05175	COG2900	Belongs to the SlyX family
E3D14_05185	COG0545	Peptidyl-prolyl cis-trans isomerase
E3D14_05190	COG2204	response regulator
E3D14_05210	COG0737	Belongs to the 5'-nucleotidase family
E3D14_05230	COG0305	Participates in initiation and elongation during chromosome replication
E3D14_05235	COG0305	Participates in initiation and elongation during chromosome replication
E3D14_05240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3D14_05245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3D14_05255	COG2199	diguanylate cyclase activity
E3D14_05255	COG2203	Gaf domain
E3D14_05255	COG2200	EAL domain
E3D14_05310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3D14_05315	COG2201	protein-glutamate methylesterase activity
E3D14_05320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E3D14_05330	COG0840	transmembrane signaling receptor activity
E3D14_05335	COG0835	chemotaxis
E3D14_05345	COG0643	Histidine kinase
E3D14_05345	COG2198	Histidine kinase
E3D14_05365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3D14_05375	COG1280	lysine exporter protein (LysE YggA)
E3D14_05390	COG3813	Protein conserved in bacteria
E3D14_05400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3D14_05415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E3D14_05440	COG0300	oxidoreductase activity
E3D14_05460	COG2133	pyrroloquinoline quinone binding
E3D14_05485	COG0077	Prephenate dehydratase
E3D14_05485	COG1605	Chorismate mutase
E3D14_05515	COG3272	Protein of unknown function (DUF1722)
E3D14_05520	COG0789	Transcriptional regulator
E3D14_05525	COG0415	Belongs to the DNA photolyase family
E3D14_05535	COG0300	oxidoreductase activity
E3D14_05550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3D14_05575	COG0783	Belongs to the Dps family
E3D14_05580	COG1151	hydroxylamine reductase activity
E3D14_05590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3D14_05595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3D14_05595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3D14_05610	COG3459	Glycosyltransferase 36 associated
E3D14_05635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3D14_05640	COG1666	GTP binding
E3D14_05645	COG3248	Nucleoside-binding outer membrane protein
E3D14_05650	COG2211	Major facilitator Superfamily
E3D14_05660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3D14_05670	COG2813	Specifically methylates the guanine in position
E3D14_05675	COG0271	Belongs to the BolA IbaG family
E3D14_05685	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E3D14_05690	COG1805	sodium ion transport
E3D14_05695	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E3D14_05700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E3D14_05705	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E3D14_05710	COG2871	sodium ion transport
E3D14_05715	COG1477	protein flavinylation
E3D14_05730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3D14_05735	COG0840	transmembrane signaling receptor activity
E3D14_05740	COG0583	DNA-binding transcription factor activity
E3D14_05750	COG2363	Small membrane protein
E3D14_05755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E3D14_05765	COG0473	3-isopropylmalate dehydrogenase activity
E3D14_05770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3D14_05775	COG1611	Belongs to the LOG family
E3D14_05780	COG3706	GGDEF domain
E3D14_05790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3D14_05790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3D14_05800	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E3D14_05825	COG3098	single-species biofilm formation
E3D14_05830	COG0564	pseudouridine synthase activity
E3D14_05840	COG4580	involved in the transport of maltose and maltodextrins
E3D14_05860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3D14_05860	COG1263	PTS System
E3D14_05870	COG2171	N-acyltransferase activity
E3D14_05875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3D14_05880	COG0024	Methionine aminopeptidase
E3D14_05885	COG0052	Belongs to the universal ribosomal protein uS2 family
E3D14_05890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3D14_05895	COG0528	UMP kinase activity
E3D14_05900	COG0233	cytoplasmic translational termination
E3D14_05905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3D14_05910	COG0575	Belongs to the CDS family
E3D14_05915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3D14_05920	COG0750	zinc metalloprotease
E3D14_05935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D14_05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3D14_05945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D14_05950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D14_05955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3D14_05965	COG0825	malonyl-CoA metabolic process
E3D14_05970	COG3710	Transcriptional regulator
E3D14_05975	COG0531	amino acid
E3D14_05980	COG1982	Orn Lys Arg decarboxylase major
E3D14_05985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3D14_06000	COG0814	amino acid
E3D14_06005	COG0531	amino acid
E3D14_06015	COG0488	(ABC) transporter
E3D14_06025	COG3590	peptidase
E3D14_06030	COG0037	tRNA processing
E3D14_06035	COG3706	GGDEF domain
E3D14_06090	COG1881	PFAM PEBP family protein
E3D14_06100	COG0583	DNA-binding transcription factor activity
E3D14_06110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3D14_06120	COG0583	DNA-binding transcription factor activity
E3D14_06125	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_06130	COG0616	signal peptide processing
E3D14_06135	COG3724	N-succinylarginine dihydrolase activity
E3D14_06140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3D14_06150	COG0840	transmembrane signaling receptor activity
E3D14_06160	COG2971	BadF BadG BcrA BcrD
E3D14_06170	COG4608	Belongs to the ABC transporter superfamily
E3D14_06175	COG0444	Belongs to the ABC transporter superfamily
E3D14_06180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3D14_06195	COG2205	protein histidine kinase activity
E3D14_06195	COG0784	Response regulator, receiver
E3D14_06230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E3D14_06235	COG1289	transmembrane transporter activity
E3D14_06240	COG0303	'Molybdopterin
E3D14_06245	COG0746	molybdenum cofactor guanylyltransferase activity
E3D14_06255	COG4662	Binding-protein-dependent transport system inner membrane component
E3D14_06270	COG3852	Histidine kinase
E3D14_06280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3D14_06285	COG2801	Transposase and inactivated derivatives
E3D14_06320	COG1196	nuclear chromosome segregation
E3D14_06320	COG3264	Mechanosensitive ion channel
E3D14_06325	COG0469	pyruvate kinase activity
E3D14_06340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3D14_06340	COG4651	solute:proton antiporter activity
E3D14_06345	COG4651	solute:proton antiporter activity
E3D14_06345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3D14_06350	COG0405	Gamma-glutamyltransferase
E3D14_06355	COG2974	May be involved in recombination
E3D14_06365	COG0420	3'-5' exonuclease activity
E3D14_06370	COG0419	ATPase involved in DNA repair
E3D14_06380	COG3038	cytochrome b561
E3D14_06390	COG3706	GGDEF domain
E3D14_06395	COG2190	(PTS) system
E3D14_06405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_06410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3D14_06430	COG1720	tRNA m6t6A37 methyltransferase activity
E3D14_06450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3D14_06455	COG4988	ABC transporter
E3D14_06470	COG0745	RESPONSE REGULATOR receiver
E3D14_06480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3D14_06495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E3D14_06500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E3D14_06515	COG0083	homoserine kinase activity
E3D14_06520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3D14_06550	COG1943	Transposase
E3D14_06570	COG0813	purine-nucleoside phosphorylase activity
E3D14_06585	COG3384	dioxygenase
E3D14_06595	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3D14_06600	COG0531	amino acid
E3D14_06605	COG0531	amino acid
E3D14_06620	COG1917	Cupin 2, conserved barrel domain protein
E3D14_06620	COG1396	sequence-specific DNA binding
E3D14_06625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3D14_06635	COG2169	Transcriptional regulator
E3D14_06635	COG1917	Cupin 2, conserved barrel domain protein
E3D14_06660	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3D14_06665	COG3328	transposase activity
E3D14_06675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3D14_06680	COG2375	cellular response to nickel ion
E3D14_06685	COG1538	Outer membrane efflux protein
E3D14_06690	COG0577	efflux transmembrane transporter activity
E3D14_06690	COG1136	(ABC) transporter
E3D14_06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_06705	COG1227	inorganic diphosphatase activity
E3D14_06710	COG0497	DNA recombination
E3D14_06715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3D14_06720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3D14_06725	COG0443	Heat shock 70 kDa protein
E3D14_06730	COG0484	heat shock protein binding
E3D14_06760	COG1285	pathogenesis
E3D14_06780	COG0640	Transcriptional regulator
E3D14_06810	COG0095	Lipoate-protein ligase
E3D14_06820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D14_06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_06850	COG0708	Exodeoxyribonuclease III
E3D14_06905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3D14_06910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3D14_06915	COG1845	cytochrome c oxidase, subunit III
E3D14_06920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3D14_06925	COG0109	protoheme IX farnesyltransferase activity
E3D14_06930	COG2814	Major facilitator Superfamily
E3D14_06950	COG1609	Transcriptional regulator
E3D14_06955	COG1263	PTS System
E3D14_06955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3D14_06960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3D14_06990	COG2207	Transcriptional regulator
E3D14_06995	COG0538	isocitrate dehydrogenase activity
E3D14_07005	COG3048	D-serine ammonia-lyase activity
E3D14_07010	COG2610	gluconate transmembrane transporter activity
E3D14_07015	COG0583	DNA-binding transcription factor activity
E3D14_07100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3D14_07105	COG2867	negative regulation of translational initiation
E3D14_07115	COG0702	epimerase
E3D14_07120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D14_07150	COG4964	Belongs to the GSP D family
E3D14_07160	COG2894	cell division
E3D14_07200	COG1454	alcohol dehydrogenase
E3D14_07215	COG1957	nucleoside hydrolase
E3D14_07235	COG0840	transmembrane signaling receptor activity
E3D14_07240	COG1280	lysine exporter protein (LysE YggA)
E3D14_07260	COG3263	regulation of cellular component size
E3D14_07270	COG1876	peptidase activity
E3D14_07275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3D14_07280	COG1393	Belongs to the ArsC family
E3D14_07285	COG0583	DNA-binding transcription factor activity
E3D14_07300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3D14_07305	COG0017	Asparaginyl-tRNA synthetase
E3D14_07325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3D14_07330	COG0156	8-amino-7-oxononanoate synthase activity
E3D14_07335	COG2226	methyltransferase
E3D14_07335	COG1073	alpha beta
E3D14_07340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3D14_07345	COG0501	Belongs to the peptidase M48B family
E3D14_07355	COG0633	Ferredoxin
E3D14_07355	COG3217	Mosc domain protein beta barrel domain protein
E3D14_07355	COG0633	Ferredoxin
E3D14_07355	COG3217	Mosc domain protein beta barrel domain protein
E3D14_07370	COG2841	Protein conserved in bacteria
E3D14_07380	COG0534	Mate efflux family protein
E3D14_07420	COG1309	transcriptional regulator
E3D14_07435	COG0791	NLP P60 protein
E3D14_07445	COG0583	DNA-binding transcription factor activity
E3D14_07455	COG0450	alkyl hydroperoxide reductase
E3D14_07475	COG0500	methyltransferase
E3D14_07480	COG4106	trans-aconitate 2-methyltransferase activity
E3D14_07490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3D14_07495	COG0217	transcriptional regulatory protein
E3D14_07515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3D14_07525	COG4584	PFAM Integrase catalytic
E3D14_07530	COG1484	DNA-dependent DNA replication
E3D14_07555	COG0604	alcohol dehydrogenase
E3D14_07555	COG3321	synthase
E3D14_07570	COG0438	transferase activity, transferring glycosyl groups
E3D14_07600	COG1846	Transcriptional regulator
E3D14_07600	COG1940	carbohydrate kinase activity
E3D14_07605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3D14_07610	COG0363	glucosamine-6-phosphate deaminase activity
E3D14_07615	COG1263	PTS System
E3D14_07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3D14_07615	COG2190	(PTS) system
E3D14_07625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3D14_07630	COG0735	belongs to the Fur family
E3D14_07640	COG0716	FMN binding
E3D14_07655	COG0596	Alpha beta hydrolase
E3D14_07660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E3D14_07665	COG0033	Phosphoglucomutase
E3D14_07675	COG1846	Transcriptional regulator
E3D14_07680	COG2951	lytic endotransglycosylase activity
E3D14_07685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3D14_07690	COG4136	ATPase activity
E3D14_07695	COG4135	transport system, permease component
E3D14_07700	COG4134	Bacterial extracellular solute-binding protein
E3D14_07710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3D14_07720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3D14_07725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3D14_07740	COG0729	surface antigen
E3D14_07745	COG2911	Protein conserved in bacteria
E3D14_07760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3D14_07785	COG1607	acyl-coa hydrolase
E3D14_07795	COG3021	interspecies interaction between organisms
E3D14_07800	COG0741	lytic transglycosylase activity
E3D14_07800	COG1388	LysM domain
E3D14_07805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3D14_07810	COG2226	methyltransferase
E3D14_07815	COG0328	RNA-DNA hybrid ribonuclease activity
E3D14_07820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3D14_07830	COG3437	response regulator, receiver
E3D14_07830	COG0784	Response regulator, receiver
E3D14_07835	COG1960	acyl-CoA dehydrogenase activity
E3D14_07840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3D14_07845	COG0121	glutamine amidotransferase
E3D14_07865	COG2205	protein histidine kinase activity
E3D14_07865	COG0784	Response regulator, receiver
E3D14_07875	COG2197	response regulator
E3D14_07880	COG3850	Histidine kinase
E3D14_07885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3D14_07890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3D14_07900	COG0243	molybdopterin cofactor binding
E3D14_07905	COG0437	4 iron, 4 sulfur cluster binding
E3D14_07910	COG0348	domain, Protein
E3D14_07920	COG3005	denitrification pathway
E3D14_07925	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3D14_07930	COG0315	cyclic pyranopterin monophosphate synthase activity
E3D14_07935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3D14_07940	COG0314	molybdopterin synthase activity
E3D14_07955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3D14_07985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3D14_07995	COG0302	gtp cyclohydrolase
E3D14_08000	COG0840	transmembrane signaling receptor activity
E3D14_08005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E3D14_08015	COG0583	DNA-binding transcription factor activity
E3D14_08020	COG2353	YceI-like domain
E3D14_08045	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3D14_08055	COG1166	arginine decarboxylase activity
E3D14_08085	COG0346	lactoylglutathione lyase activity
E3D14_08095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3D14_08100	COG1187	pseudouridine synthase activity
E3D14_08105	COG2807	transmembrane transport
E3D14_08115	COG0583	DNA-binding transcription factor activity
E3D14_08135	COG2979	Protein of unknown function (DUF533)
E3D14_08140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3D14_08150	COG1294	oxidase, subunit
E3D14_08160	COG2814	Major facilitator Superfamily
E3D14_08165	COG0656	L-ascorbic acid biosynthetic process
E3D14_08170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3D14_08195	COG0583	DNA-binding transcription factor activity
E3D14_08200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3D14_08205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3D14_08210	COG2271	Major facilitator Superfamily
E3D14_08215	COG1349	DNA-binding transcription factor activity
E3D14_08225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3D14_08230	COG0584	glycerophosphoryl diester phosphodiesterase
E3D14_08235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3D14_08240	COG1605	Chorismate mutase
E3D14_08240	COG0287	Prephenate dehydrogenase
E3D14_08250	COG3085	chromosome segregation
E3D14_08255	COG4574	serine-type endopeptidase inhibitor activity
E3D14_08275	COG1770	oligopeptidase
E3D14_08280	COG4771	TonB-dependent receptor
E3D14_08285	COG3083	sulfuric ester hydrolase activity
E3D14_08290	COG3082	Protein of unknown function (DUF1414)
E3D14_08295	COG3081	Nucleoid-associated protein
E3D14_08300	COG2182	Extracellular solute-binding protein
E3D14_08305	COG1175	transmembrane transport
E3D14_08315	COG3842	ATPase activity
E3D14_08330	COG0628	permease
E3D14_08335	COG0425	Belongs to the sulfur carrier protein TusA family
E3D14_08340	COG4783	chaperone-mediated protein folding
E3D14_08350	COG1393	Belongs to the ArsC family
E3D14_08360	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E3D14_08365	COG2431	L-lysine efflux transmembrane transporter activity
E3D14_08380	COG4215	(ABC) transporter
E3D14_08400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3D14_08415	COG2373	Large extracellular alpha-helical protein
E3D14_08420	COG4953	penicillin-binding protein 1C
E3D14_08430	COG0582	viral genome integration into host DNA
E3D14_08480	COG2974	May be involved in recombination
E3D14_08515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3D14_08775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3D14_08775	COG0301	tRNA thio-modification
E3D14_08790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3D14_08795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3D14_08825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3D14_08835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3D14_08855	COG0483	inositol monophosphate 1-phosphatase activity
E3D14_08865	COG0625	glutathione transferase activity
E3D14_08875	COG0601	transmembrane transport
E3D14_08880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3D14_08885	COG0444	Belongs to the ABC transporter superfamily
E3D14_08890	COG2814	Major facilitator Superfamily
E3D14_08895	COG0583	DNA-binding transcription factor activity
E3D14_08900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3D14_08925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3D14_08930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3D14_08935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3D14_08940	COG0509	glycine decarboxylation via glycine cleavage system
E3D14_08945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3D14_08945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3D14_08960	COG3634	alkyl hydroperoxide reductase activity
E3D14_08965	COG0450	alkyl hydroperoxide reductase
E3D14_08970	COG0517	IMP dehydrogenase activity
E3D14_08975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3D14_08980	COG0343	queuine tRNA-ribosyltransferase activity
E3D14_08985	COG1862	Preprotein translocase
E3D14_08990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D14_08995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D14_09000	COG2897	thiosulfate sulfurtransferase activity
E3D14_09040	COG1104	cysteine desulfurase activity
E3D14_09045	COG0822	iron-sulfur transferase activity
E3D14_09055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3D14_09060	COG0443	Heat shock 70 kDa protein
E3D14_09065	COG0633	Ferredoxin
E3D14_09075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3D14_09080	COG0105	UTP biosynthetic process
E3D14_09085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3D14_09095	COG1426	Protein conserved in bacteria
E3D14_09100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3D14_09105	COG0124	histidyl-tRNA synthetase
E3D14_09110	COG2976	Protein conserved in bacteria
E3D14_09115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D14_09120	COG1160	GTP binding
E3D14_09125	COG1645	bacterial-type flagellum-dependent swarming motility
E3D14_09130	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3D14_09135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3D14_09135	COG0047	phosphoribosylformylglycinamidine synthase activity
E3D14_09145	COG2354	Protein conserved in bacteria
E3D14_09165	COG1252	NADH dehydrogenase
E3D14_09170	COG0393	Putative heavy-metal-binding
E3D14_09180	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3D14_09185	COG1368	sulfuric ester hydrolase activity
E3D14_09195	COG0527	aspartate kinase activity
E3D14_09200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3D14_09200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3D14_09205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3D14_09250	COG1285	pathogenesis
E3D14_09310	COG0672	)-iron permease
E3D14_09350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E3D14_09355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3D14_09355	COG0574	Belongs to the PEP-utilizing enzyme family
E3D14_09395	COG1464	Belongs to the NlpA lipoprotein family
E3D14_09400	COG0671	phosphoesterase, PA-phosphatase related
E3D14_09405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3D14_09410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3D14_09420	COG0101	tRNA pseudouridine synthase activity
E3D14_09425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3D14_09430	COG0285	dihydrofolate synthase activity
E3D14_09435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E3D14_09440	COG2920	part of a sulfur-relay system
E3D14_09445	COG1289	transmembrane transporter activity
E3D14_09450	COG0670	Belongs to the BI1 family
E3D14_09460	COG0840	transmembrane signaling receptor activity
E3D14_09470	COG0564	pseudouridine synthase activity
E3D14_09495	COG0625	glutathione transferase activity
E3D14_09500	COG0625	glutathione transferase activity
E3D14_09520	COG0367	asparagine synthase
E3D14_09530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3D14_09530	COG4651	solute:proton antiporter activity
E3D14_09535	COG0647	UMP catabolic process
E3D14_09540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3D14_09545	COG1902	pentaerythritol trinitrate reductase activity
E3D14_09550	COG1253	flavin adenine dinucleotide binding
E3D14_09560	COG0247	lactate metabolic process
E3D14_09560	COG0277	FAD linked oxidase domain protein
E3D14_09570	COG2050	protein possibly involved in aromatic compounds catabolism
E3D14_09575	COG0513	Belongs to the DEAD box helicase family
E3D14_09585	COG5001	Diguanylate cyclase
E3D14_09585	COG3300	MHYT domain
E3D14_09590	COG2056	Na+-H+ antiporter family
E3D14_09595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3D14_09610	COG0346	lactoylglutathione lyase activity
E3D14_09615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3D14_09625	COG4659	FMN binding
E3D14_09630	COG4658	electron transport chain
E3D14_09640	COG2878	Part of a membrane complex involved in electron transport
E3D14_09645	COG4657	Part of a membrane complex involved in electron transport
E3D14_09650	COG0697	spore germination
E3D14_09690	COG0659	secondary active sulfate transmembrane transporter activity
E3D14_09825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3D14_09830	COG1278	Cold shock
E3D14_09835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3D14_09840	COG0542	response to heat
E3D14_09845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3D14_09850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E3D14_09855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3D14_09860	COG3134	Outer membrane lipoprotein
E3D14_09865	COG3706	GGDEF domain
E3D14_09870	COG0492	ferredoxin-NADP+ reductase activity
E3D14_09890	COG1674	ftsk spoiiie
E3D14_09890	COG0531	amino acid
E3D14_09895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3D14_09900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3D14_09905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3D14_09910	COG1286	toxin biosynthetic process
E3D14_09915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3D14_09925	COG4172	Belongs to the ABC transporter superfamily
E3D14_09930	COG4172	Belongs to the ABC transporter superfamily
E3D14_09935	COG4171	peptide transport system, permease
E3D14_09940	COG4168	peptide transport system, permease
E3D14_09950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E3D14_09955	COG1842	Phage shock protein A
E3D14_09970	COG3106	COG3106 Predicted ATPase
E3D14_09975	COG3768	UPF0283 membrane protein
E3D14_09985	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3D14_10000	COG2199	diguanylate cyclase activity
E3D14_10010	COG0861	Integral membrane protein TerC family
E3D14_10025	COG1022	Amp-dependent synthetase and ligase
E3D14_10030	COG0295	cytidine deaminase activity
E3D14_10035	COG1346	cytolysis
E3D14_10040	COG1380	Effector of murein hydrolase LrgA
E3D14_10055	COG2925	Exonuclease
E3D14_10070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3D14_10080	COG0583	DNA-binding transcription factor activity
E3D14_10085	COG2160	L-arabinose isomerase activity
E3D14_10095	COG1069	ribulokinase activity
E3D14_10100	COG1879	ABC-type sugar transport system periplasmic component
E3D14_10105	COG1129	ABC transporter
E3D14_10110	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3D14_10120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3D14_10125	COG1085	galactose-1-phosphate uridylyltransferase
E3D14_10130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3D14_10135	COG1609	Transcriptional regulator
E3D14_10140	COG4580	involved in the transport of maltose and maltodextrins
E3D14_10180	COG2182	Extracellular solute-binding protein
E3D14_10185	COG1175	transmembrane transport
E3D14_10190	COG3833	ABC-type maltose transport systems, permease component
E3D14_10195	COG3867	Arabinogalactan endo-beta-1,4-galactanase
E3D14_10200	COG1874	Beta-galactosidase
E3D14_10210	COG0469	pyruvate kinase activity
E3D14_10215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3D14_10220	COG0254	rRNA binding
E3D14_10235	COG1451	nucleotide metabolic process
E3D14_10250	COG3069	C4-dicarboxylate transmembrane transporter activity
E3D14_10260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3D14_10260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3D14_10265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3D14_10285	COG2009	succinate dehydrogenase
E3D14_10290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3D14_10295	COG1053	succinate dehydrogenase
E3D14_10305	COG0567	Dehydrogenase, E1 component
E3D14_10310	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3D14_10315	COG0045	succinate-CoA ligase (ADP-forming) activity
E3D14_10320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3D14_10330	COG1882	Formate acetyltransferase
E3D14_10335	COG2116	formate transmembrane transporter activity
E3D14_10340	COG1944	ATP diphosphatase activity
E3D14_10345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3D14_10350	COG0612	Peptidase, M16
E3D14_10365	COG2910	NAD(P)H-binding
E3D14_10370	COG0583	DNA-binding transcription factor activity
E3D14_10380	COG3708	Transcriptional regulator
E3D14_10380	COG2207	Transcriptional regulator
E3D14_10385	COG4774	siderophore transport
E3D14_10395	COG0583	DNA-binding transcription factor activity
E3D14_10400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3D14_10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3D14_10430	COG3046	protein related to deoxyribodipyrimidine photolyase
E3D14_10440	COG3033	Beta-eliminating lyase
E3D14_10455	COG4235	cytochrome complex assembly
E3D14_10455	COG3088	subunit of a heme lyase
E3D14_10470	COG3301	Polysulphide reductase, NrfD
E3D14_10475	COG0437	4 iron, 4 sulfur cluster binding
E3D14_10480	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E3D14_10490	COG0247	lactate metabolic process
E3D14_10495	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E3D14_10500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3D14_10505	COG3012	SEC-C Motif Domain Protein
E3D14_10510	COG0840	transmembrane signaling receptor activity
E3D14_10515	COG1846	Transcriptional regulator
E3D14_10515	COG1940	carbohydrate kinase activity
E3D14_10520	COG3290	protein histidine kinase activity
E3D14_10525	COG4565	transcriptional regulatory protein
E3D14_10545	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3D14_10550	COG0569	domain protein
E3D14_10550	COG2985	domain, Protein
E3D14_10565	COG0556	nucleotide-excision repair
E3D14_10575	COG0586	Pfam SNARE associated Golgi protein
E3D14_10580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3D14_10585	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3D14_10590	COG2186	Transcriptional regulator
E3D14_10595	COG2719	SpoVR family
E3D14_10605	COG2766	serine protein kinase
E3D14_10610	COG0514	ATP-dependent DNA helicase (RecQ)
E3D14_10615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E3D14_10620	COG0814	amino acid
E3D14_10630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3D14_10660	COG0058	SHG alpha-glucan phosphorylase activity
E3D14_10665	COG0471	metal ion transport
E3D14_10670	COG3118	belongs to the thioredoxin family
E3D14_10685	COG1132	(ABC) transporter
E3D14_10695	COG2501	S4 domain
E3D14_10705	COG3243	poly(R)-hydroxyalkanoic acid synthase
E3D14_10725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3D14_10730	COG2329	Antibiotic biosynthesis monooxygenase
E3D14_10770	COG1742	UPF0060 membrane protein
E3D14_10785	COG0513	Belongs to the DEAD box helicase family
E3D14_10790	COG0386	Belongs to the glutathione peroxidase family
E3D14_10800	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3D14_10815	COG0730	response to heat
E3D14_10820	COG0583	DNA-binding transcription factor activity
E3D14_10835	COG3593	DNA synthesis involved in DNA repair
E3D14_10875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3D14_10880	COG1011	Hydrolase
E3D14_10925	COG0205	6-phosphofructokinase activity
E3D14_10935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3D14_10940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3D14_10950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E3D14_10955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E3D14_10960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3D14_11025	COG4681	YaeQ
E3D14_11045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D14_11065	COG3134	Outer membrane lipoprotein
E3D14_11085	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_11090	COG0583	DNA-binding transcription factor activity
E3D14_11095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E3D14_11100	COG0673	inositol 2-dehydrogenase activity
E3D14_11105	COG0583	DNA-binding transcription factor activity
E3D14_11115	COG1560	Kdo2-lipid A biosynthetic process
E3D14_11120	COG1560	Kdo2-lipid A biosynthetic process
E3D14_11135	COG2203	Gaf domain
E3D14_11135	COG2199	diguanylate cyclase activity
E3D14_11145	COG0417	DNA replication proofreading
E3D14_11170	COG0534	Mate efflux family protein
E3D14_11180	COG0307	riboflavin synthase, alpha
E3D14_11190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D14_11195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E3D14_11205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3D14_11245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3D14_11255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3D14_11260	COG2894	cell division
E3D14_11265	COG0850	regulation of cytokinetic process
E3D14_11270	COG3100	YcgL domain-containing protein
E3D14_11275	COG2951	lytic endotransglycosylase activity
E3D14_11280	COG1760	l-serine dehydratase
E3D14_11290	COG1760	l-serine dehydratase
E3D14_11295	COG3123	guanosine phosphorylase activity
E3D14_11315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E3D14_11320	COG2067	long-chain fatty acid transport protein
E3D14_11325	COG2067	long-chain fatty acid transport protein
E3D14_11365	COG0714	Associated with various cellular activities
E3D14_11370	COG0183	Belongs to the thiolase family
E3D14_11375	COG1024	Enoyl-CoA hydratase
E3D14_11375	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3D14_11380	COG2824	Alkylphosphonate utilization operon protein PhnA
E3D14_11400	COG1879	ABC-type sugar transport system periplasmic component
E3D14_11405	COG1129	ABC transporter
E3D14_11415	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3D14_11420	COG4251	negative regulation of phosphorylation
E3D14_11420	COG2203	Gaf domain
E3D14_11420	COG3706	GGDEF domain
E3D14_11420	COG5001	Diguanylate cyclase
E3D14_11425	COG2823	Periplasmic or secreted lipoprotein
E3D14_11490	COG2378	regulation of single-species biofilm formation
E3D14_11500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3D14_11500	COG0140	phosphoribosyl-ATP diphosphatase activity
E3D14_11505	COG0107	imidazoleglycerol-phosphate synthase activity
E3D14_11510	COG0784	Response regulator, receiver
E3D14_11510	COG2198	Histidine kinase
E3D14_11510	COG2205	protein histidine kinase activity
E3D14_11520	COG3437	response regulator, receiver
E3D14_11525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3D14_11530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3D14_11535	COG0131	Imidazoleglycerol-phosphate dehydratase
E3D14_11535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3D14_11540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3D14_11545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3D14_11550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3D14_11560	COG1199	ATP-dependent helicase activity
E3D14_11565	COG1214	PFAM Peptidase M22, glycoprotease
E3D14_11575	COG2267	carboxylic ester hydrolase activity
E3D14_11580	COG0318	PFAM AMP-dependent synthetase and ligase
E3D14_11600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3D14_11605	COG2832	Protein of unknown function (DUF454)
E3D14_11610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3D14_11615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3D14_11620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3D14_11630	COG2197	response regulator
E3D14_11640	COG1643	Atp-dependent helicase
E3D14_11650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3D14_11655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3D14_11660	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E3D14_11665	COG0709	Synthesizes selenophosphate from selenide and ATP
E3D14_11680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3D14_11690	COG1254	Belongs to the acylphosphatase family
E3D14_11700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D14_11700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D14_11705	COG0489	protein tyrosine kinase activity
E3D14_11710	COG0572	uridine kinase
E3D14_11715	COG0717	Belongs to the dCTP deaminase family
E3D14_11720	COG0306	phosphate transporter
E3D14_11725	COG1530	ribonuclease E activity
E3D14_11735	COG0546	phosphoglycolate phosphatase activity
E3D14_11740	COG0424	maF-like protein
E3D14_11745	COG1399	metal-binding, possibly nucleic acid-binding protein
E3D14_11750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3D14_11755	COG0416	fatty acid biosynthetic process
E3D14_11760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3D14_11770	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_11775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3D14_11780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3D14_11785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3D14_11790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3D14_11795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3D14_11800	COG0470	DNA polymerase III
E3D14_11805	COG0084	hydrolase, TatD family'
E3D14_11820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3D14_11820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E3D14_11830	COG2995	paraquat-inducible protein a
E3D14_11840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3D14_11890	COG4221	oxidoreductase activity
E3D14_11965	COG4128	Pfam Zonular occludens toxin
E3D14_11975	COG1484	DNA-dependent DNA replication
E3D14_12040	COG4128	Pfam Zonular occludens toxin
E3D14_12055	COG1067	ATP-dependent peptidase activity
E3D14_12060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3D14_12085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3D14_12085	COG0116	Belongs to the methyltransferase superfamily
E3D14_12095	COG0167	dihydroorotate dehydrogenase activity
E3D14_12100	COG2902	Dehydrogenase
E3D14_12110	COG0308	aminopeptidase N
E3D14_12120	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E3D14_12125	COG1956	GAF domain-containing protein
E3D14_12135	COG3278	Belongs to the heme-copper respiratory oxidase family
E3D14_12150	COG2010	Cytochrome c
E3D14_12160	COG2217	Heavy metal translocating P-type atpase
E3D14_12175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3D14_12180	COG0589	response to stress
E3D14_12185	COG0037	tRNA processing
E3D14_12200	COG0625	glutathione transferase activity
E3D14_12205	COG1869	D-ribose catabolic process
E3D14_12215	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3D14_12220	COG1879	ABC-type sugar transport system periplasmic component
E3D14_12225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3D14_12230	COG1609	Transcriptional regulator
E3D14_12235	COG2199	diguanylate cyclase activity
E3D14_12245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3D14_12265	COG0776	regulation of translation
E3D14_12270	COG0072	phenylalanine-tRNA ligase activity
E3D14_12270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3D14_12275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3D14_12280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3D14_12285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3D14_12290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3D14_12295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3D14_12315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3D14_12325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D14_12330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3D14_12335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3D14_12340	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E3D14_12345	COG3313	Fe-S protein
E3D14_12350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3D14_12350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3D14_12350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E3D14_12355	COG1105	Belongs to the carbohydrate kinase PfkB family
E3D14_12360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_12360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_12365	COG1609	Transcriptional regulator
E3D14_12370	COG0814	amino acid
E3D14_12380	COG5654	RES domain protein
E3D14_12385	COG0513	Belongs to the DEAD box helicase family
E3D14_12395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3D14_12400	COG2890	protein-(glutamine-N5) methyltransferase activity
E3D14_12405	COG2840	Smr protein MutS2
E3D14_12410	COG3706	GGDEF domain
E3D14_12460	COG0730	response to heat
E3D14_12470	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_12480	COG1024	Enoyl-CoA hydratase
E3D14_12485	COG1024	Enoyl-CoA hydratase
E3D14_12490	COG1960	acyl-CoA dehydrogenase activity
E3D14_12500	COG1960	acyl-CoA dehydrogenase activity
E3D14_12505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3D14_12510	COG1024	Enoyl-CoA hydratase
E3D14_12540	COG1584	GPR1 FUN34 yaaH family protein
E3D14_12550	COG0456	acetyltransferase
E3D14_12555	COG1115	amino acid carrier protein
E3D14_12560	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3D14_12560	COG1024	Enoyl-CoA hydratase
E3D14_12575	COG3162	membrane
E3D14_12580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3D14_12585	COG0488	(ABC) transporter
E3D14_12590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3D14_12595	COG0776	regulation of translation
E3D14_12600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3D14_12605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3D14_12610	COG0740	serine-type endopeptidase activity
E3D14_12615	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3D14_12630	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E3D14_12635	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3D14_12640	COG1136	(ABC) transporter
E3D14_12645	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3D14_12655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3D14_12660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E3D14_12665	COG4166	transmembrane transport
E3D14_12670	COG0697	spore germination
E3D14_12680	COG2062	phosphohistidine phosphatase, SixA
E3D14_12685	COG1025	Belongs to the peptidase M16 family
E3D14_12720	COG0519	Catalyzes the synthesis of GMP from XMP
E3D14_12720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3D14_12725	COG0516	GMP reductase activity
E3D14_12725	COG0517	IMP dehydrogenase activity
E3D14_12745	COG3038	cytochrome b561
E3D14_12750	COG1570	exodeoxyribonuclease VII activity
E3D14_12765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3D14_12770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3D14_12775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3D14_12795	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3D14_12795	COG0644	oxidoreductase
E3D14_12800	COG0598	Magnesium transport protein CorA
E3D14_12820	COG4771	TonB-dependent receptor
E3D14_12825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D14_12830	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D14_12835	COG1120	ATPase activity
E3D14_12840	COG2977	Belongs to the P-Pant transferase superfamily
E3D14_12845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3D14_12850	COG0300	oxidoreductase activity
E3D14_12850	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_12850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3D14_12850	COG3321	synthase
E3D14_12850	COG0318	PFAM AMP-dependent synthetase and ligase
E3D14_12860	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_12865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3D14_12870	COG3433	isochorismatase activity
E3D14_12870	COG1535	isochorismatase
E3D14_12875	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3D14_12895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3D14_12900	COG5001	Diguanylate cyclase
E3D14_12900	COG3300	MHYT domain
E3D14_12915	COG0840	transmembrane signaling receptor activity
E3D14_12920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3D14_12925	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E3D14_12930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3D14_12935	COG0563	adenylate kinase activity
E3D14_12945	COG0326	Molecular chaperone. Has ATPase activity
E3D14_12950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3D14_12975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3D14_12995	COG3158	transport of potassium into the cell
E3D14_13000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3D14_13005	COG0651	ATP synthesis coupled electron transport
E3D14_13010	COG0650	Formate hydrogenlyase subunit 4
E3D14_13015	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3D14_13015	COG3261	NADH dehydrogenase
E3D14_13020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13025	COG3260	NADH ubiquinone oxidoreductase 20
E3D14_13035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3D14_13040	COG1921	L-seryl-tRNASec selenium transferase activity
E3D14_13050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E3D14_13055	COG0298	carbon dioxide binding
E3D14_13065	COG0309	Hydrogenase expression formation protein (HypE)
E3D14_13070	COG0375	protein maturation
E3D14_13075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E3D14_13090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3D14_13095	COG0601	transmembrane transport
E3D14_13105	COG1773	rubredoxin
E3D14_13110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3D14_13115	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3D14_13120	COG5557	Pfam Polysulphide reductase, NrfD
E3D14_13125	COG0437	4 iron, 4 sulfur cluster binding
E3D14_13130	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3D14_13135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3D14_13160	COG1435	thymidine kinase activity
E3D14_13165	COG1757	Na H antiporter
E3D14_13175	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3D14_13180	COG2096	Adenosyltransferase
E3D14_13185	COG3530	Putative quorum-sensing-regulated virulence factor
E3D14_13190	COG0602	queuosine metabolic process
E3D14_13195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3D14_13210	COG0284	orotidine-5'-phosphate decarboxylase activity
E3D14_13215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3D14_13225	COG0776	regulation of translation
E3D14_13230	COG0539	negative regulation of cytoplasmic translation
E3D14_13235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3D14_13240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3D14_13250	COG0583	DNA-binding transcription factor activity
E3D14_13255	COG2814	Major facilitator Superfamily
E3D14_13290	COG0583	DNA-binding transcription factor activity
E3D14_13295	COG3437	response regulator, receiver
E3D14_13320	COG4989	oxidoreductase activity
E3D14_13325	COG0724	RNA recognition motif
E3D14_13335	COG1126	abc transporter atp-binding protein
E3D14_13340	COG0765	amino acid transport
E3D14_13345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_13350	COG4597	amino acid ABC transporter
E3D14_13365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3D14_13380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3D14_13385	COG1360	Flagellar Motor Protein
E3D14_13390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13400	COG0649	NAD binding
E3D14_13400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13415	COG1034	ATP synthesis coupled electron transport
E3D14_13420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E3D14_13425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13430	COG0839	Belongs to the complex I subunit 6 family
E3D14_13435	COG0713	ATP synthesis coupled electron transport
E3D14_13445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_13450	COG1007	ATP synthesis coupled electron transport
E3D14_13470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D14_13475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3D14_13510	COG0537	adenosine 5'-monophosphoramidase activity
E3D14_13525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3D14_13540	COG1301	dicarboxylic acid transport
E3D14_13550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3D14_13555	COG0861	Integral membrane protein TerC family
E3D14_13570	COG0444	Belongs to the ABC transporter superfamily
E3D14_13575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3D14_13580	COG0601	transmembrane transport
E3D14_13590	COG2095	MarC family integral membrane protein
E3D14_13600	COG1012	belongs to the aldehyde dehydrogenase family
E3D14_13600	COG1454	alcohol dehydrogenase
E3D14_13610	COG3275	phosphorelay sensor kinase activity
E3D14_13615	COG3279	Response regulator of the LytR AlgR family
E3D14_13620	COG1966	Carbon starvation protein
E3D14_13630	COG1566	PFAM secretion protein HlyD family protein
E3D14_13635	COG1061	Type III restriction enzyme res subunit
E3D14_13640	COG2027	D-alanyl-D-alanine carboxypeptidase
E3D14_13645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3D14_13655	COG0436	Aminotransferase
E3D14_13660	COG1288	antiporter activity
E3D14_13665	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3D14_13735	COG1242	4 iron, 4 sulfur cluster binding
E3D14_13740	COG0067	glutamate synthase
E3D14_13740	COG0069	glutamate synthase activity
E3D14_13740	COG0070	glutamate synthase
E3D14_13745	COG0493	'glutamate synthase
E3D14_13760	COG0789	Transcriptional regulator
E3D14_13785	COG0513	Belongs to the DEAD box helicase family
E3D14_13790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3D14_13830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3D14_13835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3D14_13840	COG0505	Belongs to the CarA family
E3D14_13845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3D14_13860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3D14_13865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3D14_13870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3D14_13875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3D14_13880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3D14_13885	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E3D14_13895	COG2205	protein histidine kinase activity
E3D14_13895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_13935	COG0023	Translation Initiation Factor
E3D14_13940	COG2119	membrane
E3D14_14000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3D14_14010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3D14_14040	COG4974	Belongs to the 'phage' integrase family
E3D14_14050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3D14_14115	COG4695	Portal protein
E3D14_14255	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E3D14_14280	COG0322	excinuclease ABC activity
E3D14_14285	COG2197	response regulator
E3D14_14290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E3D14_14295	COG2835	tetraacyldisaccharide 4'-kinase activity
E3D14_14300	COG1663	tetraacyldisaccharide 4'-kinase activity
E3D14_14305	COG1132	(ABC) transporter
E3D14_14310	COG0658	competence protein
E3D14_14310	COG2333	competence protein COMEC
E3D14_14325	COG0433	COG0433 Predicted ATPase
E3D14_14330	COG1448	Aminotransferase
E3D14_14340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3D14_14345	COG1199	ATP-dependent helicase activity
E3D14_14355	COG0123	including yeast histone deacetylase and acetoin utilization protein
E3D14_14360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3D14_14365	COG1785	Belongs to the alkaline phosphatase family
E3D14_14385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3D14_14400	COG2271	Major facilitator Superfamily
E3D14_14405	COG3706	GGDEF domain
E3D14_14410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_14415	COG0765	amino acid transport
E3D14_14420	COG1126	abc transporter atp-binding protein
E3D14_14430	COG0531	amino acid
E3D14_14445	COG1253	flavin adenine dinucleotide binding
E3D14_14450	COG0704	Plays a role in the regulation of phosphate uptake
E3D14_14460	COG0581	inorganic phosphate transmembrane transporter activity
E3D14_14465	COG0573	inorganic phosphate transmembrane transporter activity
E3D14_14470	COG0590	tRNA wobble adenosine to inosine editing
E3D14_14480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3D14_14500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E3D14_14505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3D14_14510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3D14_14515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3D14_14520	COG2204	response regulator
E3D14_14525	COG3852	Histidine kinase
E3D14_14545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3D14_14550	COG0248	Ppx GppA phosphatase
E3D14_14555	COG2239	Acts as a magnesium transporter
E3D14_14575	COG1706	bacterial-type flagellum-dependent cell motility
E3D14_14580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E3D14_14585	COG4786	Flagellar basal body rod
E3D14_14590	COG4787	bacterial-type flagellum-dependent cell motility
E3D14_14605	COG1558	bacterial-type flagellum-dependent cell motility
E3D14_14610	COG1815	bacterial-type flagellum-dependent cell motility
E3D14_14615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3D14_14620	COG0784	Response regulator, receiver
E3D14_14620	COG0835	chemotaxis
E3D14_14640	COG0622	Phosphoesterase
E3D14_14645	COG4166	transmembrane transport
E3D14_14655	COG1187	pseudouridine synthase activity
E3D14_14700	COG1278	Cold shock
E3D14_14740	COG1484	DNA-dependent DNA replication
E3D14_14745	COG4584	PFAM Integrase catalytic
E3D14_14760	COG3132	Protein of unknown function, DUF480
E3D14_14770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3D14_14785	COG0438	transferase activity, transferring glycosyl groups
E3D14_14820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3D14_14840	COG0490	domain, Protein
E3D14_14840	COG0471	metal ion transport
E3D14_14845	COG0471	metal ion transport
E3D14_14845	COG3273	potassium ion transport
E3D14_14865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3D14_14870	COG0438	transferase activity, transferring glycosyl groups
E3D14_14890	COG1450	Type ii and iii secretion system protein
E3D14_14930	COG1459	type II secretion system
E3D14_14935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3D14_14955	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3D14_14970	COG1538	Outer membrane efflux protein
E3D14_14975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D14_14980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_14985	COG1309	transcriptional regulator
E3D14_15000	COG1946	Acyl-CoA thioesterase
E3D14_15010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3D14_15020	COG0009	L-threonylcarbamoyladenylate synthase
E3D14_15025	COG0613	PHP domain protein
E3D14_15030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3D14_15035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3D14_15035	COG0512	Glutamine amidotransferase of anthranilate synthase
E3D14_15040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3D14_15045	COG0135	phosphoribosylanthranilate isomerase activity
E3D14_15045	COG0134	indole-3-glycerol-phosphate synthase activity
E3D14_15050	COG0133	tryptophan synthase activity
E3D14_15055	COG0159	tryptophan synthase activity
E3D14_15085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3D14_15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_15085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3D14_15095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3D14_15115	COG0482	sulfurtransferase activity
E3D14_15120	COG2915	High frequency lysogenization protein hflD homolog
E3D14_15125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3D14_15130	COG2850	peptidyl-arginine hydroxylation
E3D14_15150	COG3153	acetyltransferase
E3D14_15160	COG0625	glutathione transferase activity
E3D14_15165	COG0259	pyridoxamine-phosphate oxidase activity
E3D14_15180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3D14_15180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3D14_15185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3D14_15205	COG4235	cytochrome complex assembly
E3D14_15205	COG3088	subunit of a heme lyase
E3D14_15210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3D14_15215	COG1138	Cytochrome C-type biogenesis protein
E3D14_15220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3D14_15225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3D14_15230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3D14_15235	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3D14_15250	COG0835	chemotaxis
E3D14_15260	COG1192	Involved in chromosome partitioning
E3D14_15265	COG1360	Flagellar Motor Protein
E3D14_15270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3D14_15275	COG2201	protein-glutamate methylesterase activity
E3D14_15280	COG2198	Histidine kinase
E3D14_15280	COG0643	Histidine kinase
E3D14_15285	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E3D14_15300	COG0455	bacterial-type flagellum organization
E3D14_15310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3D14_15320	COG1684	flagellar biosynthetic protein fliR
E3D14_15325	COG1987	bacterial-type flagellum assembly
E3D14_15375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3D14_15385	COG1677	Flagellar hook-basal body complex protein FliE
E3D14_15395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E3D14_15410	COG1342	Belongs to the UPF0251 family
E3D14_15430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3D14_15440	COG0745	RESPONSE REGULATOR receiver
E3D14_15445	COG3290	protein histidine kinase activity
E3D14_15455	COG1737	Transcriptional regulator
E3D14_15460	COG0469	pyruvate kinase activity
E3D14_15470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D14_15475	COG1960	acyl-CoA dehydrogenase activity
E3D14_15485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3D14_15520	COG3209	COG3209 Rhs family protein
E3D14_15530	COG1484	DNA-dependent DNA replication
E3D14_15535	COG4584	PFAM Integrase catalytic
E3D14_15570	COG1376	ErfK ybiS ycfS ynhG family protein
E3D14_15570	COG1388	LysM domain
E3D14_15585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E3D14_15590	COG0791	NLP P60 protein
E3D14_15595	COG2091	lysine biosynthetic process via aminoadipic acid
E3D14_15600	COG3118	belongs to the thioredoxin family
E3D14_15610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3D14_15615	COG0788	formyltetrahydrofolate deformylase activity
E3D14_15625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3D14_15645	COG0366	Alpha amylase catalytic
E3D14_15650	COG0739	heme binding
E3D14_15650	COG0741	lytic transglycosylase activity
E3D14_15650	COG1196	nuclear chromosome segregation
E3D14_15655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3D14_15660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3D14_15665	COG0673	inositol 2-dehydrogenase activity
E3D14_15700	COG1032	radical SAM domain protein
E3D14_15710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3D14_15715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_15720	COG3706	GGDEF domain
E3D14_15725	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3D14_15730	COG0733	neurotransmitter:sodium symporter activity
E3D14_15755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3D14_15755	COG2885	chlorophyll binding
E3D14_15760	COG0281	malic enzyme
E3D14_15765	COG2207	Transcriptional regulator
E3D14_15770	COG0534	Mate efflux family protein
E3D14_15780	COG3706	GGDEF domain
E3D14_15780	COG0745	RESPONSE REGULATOR receiver
E3D14_15785	COG2233	PERMEase
E3D14_15790	COG0095	Lipoate-protein ligase
E3D14_15795	COG1115	amino acid carrier protein
E3D14_15800	COG0019	diaminopimelate decarboxylase activity
E3D14_15820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E3D14_15840	COG1131	(ABC) transporter
E3D14_15845	COG0545	Peptidyl-prolyl cis-trans isomerase
E3D14_15850	COG3142	Participates in the control of copper homeostasis
E3D14_15855	COG1940	carbohydrate kinase activity
E3D14_15865	COG4783	chaperone-mediated protein folding
E3D14_15875	COG5002	protein histidine kinase activity
E3D14_15880	COG0745	RESPONSE REGULATOR receiver
E3D14_15885	COG0346	lactoylglutathione lyase activity
E3D14_15915	COG3290	protein histidine kinase activity
E3D14_15920	COG0281	malic enzyme
E3D14_15935	COG1846	Transcriptional regulator
E3D14_15940	COG1566	PFAM secretion protein HlyD family protein
E3D14_15965	COG0602	queuosine metabolic process
E3D14_15975	COG1328	CTP reductase activity
E3D14_15985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3D14_15990	COG3115	cell septum assembly
E3D14_15995	COG1196	nuclear chromosome segregation
E3D14_16005	COG2860	membrane
E3D14_16015	COG3108	Peptidase M15
E3D14_16020	COG2989	Protein conserved in bacteria
E3D14_16035	COG0463	Glycosyl transferase, family 2
E3D14_16050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3D14_16055	COG0739	heme binding
E3D14_16060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3D14_16075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3D14_16085	COG3091	SprT-like family
E3D14_16095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3D14_16100	COG0189	ligase activity
E3D14_16110	COG1678	Uncharacterized ACR, COG1678
E3D14_16115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3D14_16120	COG0583	DNA-binding transcription factor activity
E3D14_16135	COG0714	Associated with various cellular activities
E3D14_16150	COG1115	amino acid carrier protein
E3D14_16155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3D14_16170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E3D14_16190	COG1301	dicarboxylic acid transport
E3D14_16210	COG2890	protein-(glutamine-N5) methyltransferase activity
E3D14_16215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3D14_16220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3D14_16225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3D14_16230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3D14_16240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3D14_16245	COG0737	Belongs to the 5'-nucleotidase family
E3D14_16250	COG0193	aminoacyl-tRNA hydrolase activity
E3D14_16255	COG0012	GTP binding
E3D14_16325	COG0471	metal ion transport
E3D14_16325	COG0490	domain, Protein
E3D14_16335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E3D14_16365	COG0443	Heat shock 70 kDa protein
E3D14_16375	COG0366	Alpha amylase catalytic
E3D14_16390	COG0488	(ABC) transporter
E3D14_16400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3D14_16400	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3D14_16400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3D14_16400	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3D14_16410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D14_16420	COG1012	belongs to the aldehyde dehydrogenase family
E3D14_16430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3D14_16445	COG0180	Tryptophanyl-tRNA synthetase
E3D14_16450	COG0546	phosphoglycolate phosphatase activity
E3D14_16455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3D14_16460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3D14_16470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3D14_16475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3D14_16505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E3D14_16510	COG0583	DNA-binding transcription factor activity
E3D14_16530	COG0583	DNA-binding transcription factor activity
E3D14_16545	COG0739	heme binding
E3D14_16565	COG1511	domain protein
E3D14_16565	COG3264	Mechanosensitive ion channel
E3D14_16570	COG0584	glycerophosphoryl diester phosphodiesterase
E3D14_16580	COG1053	succinate dehydrogenase
E3D14_16585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3D14_16590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E3D14_16595	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E3D14_16615	COG3214	Protein conserved in bacteria
E3D14_16650	COG0745	RESPONSE REGULATOR receiver
E3D14_16655	COG0642	Histidine kinase
E3D14_16665	COG0516	GMP reductase activity
E3D14_16675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3D14_16685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3D14_16705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D14_16720	COG3706	GGDEF domain
E3D14_16730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3D14_16735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3D14_16740	COG1702	phosphate starvation-inducible protein PhoH
E3D14_16745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3D14_16750	COG4535	Mg2 and Co2 transporter CorC
E3D14_16755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3D14_16760	COG2888	peptidyl-tyrosine sulfation
E3D14_16765	COG0495	leucyl-tRNA aminoacylation
E3D14_16785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3D14_16790	COG0799	negative regulation of ribosome biogenesis
E3D14_16795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3D14_16800	COG0768	penicillin binding
E3D14_16805	COG0772	Belongs to the SEDS family
E3D14_16815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3D14_16820	COG1686	Belongs to the peptidase S11 family
E3D14_16825	COG2921	Belongs to the UPF0250 family
E3D14_16830	COG0321	lipoyl(octanoyl) transferase activity
E3D14_16835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3D14_16870	COG1484	DNA-dependent DNA replication
E3D14_16875	COG4584	PFAM Integrase catalytic
E3D14_16920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3D14_16925	COG3545	Serine hydrolase
E3D14_16940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3D14_16950	COG1970	mechanosensitive ion channel activity
E3D14_16955	COG3706	GGDEF domain
E3D14_16960	COG4974	Belongs to the 'phage' integrase family
E3D14_16965	COG0716	FMN binding
E3D14_16975	COG0312	modulator of DNA gyrase
E3D14_17030	COG1422	Protein of unknown function (DUF1090)
E3D14_17035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3D14_17040	COG3706	GGDEF domain
E3D14_17050	COG1185	polyribonucleotide nucleotidyltransferase activity
E3D14_17055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3D14_17060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3D14_17065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3D14_17070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3D14_17075	COG0195	Participates in both transcription termination and antitermination
E3D14_17080	COG0779	Required for maturation of 30S ribosomal subunits
E3D14_17095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3D14_17100	COG0149	triose-phosphate isomerase activity
E3D14_17105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3D14_17110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3D14_17115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3D14_17120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3D14_17125	COG1534	Rna-binding protein
E3D14_17135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3D14_17150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3D14_17155	COG1722	exodeoxyribonuclease VII activity
E3D14_17160	COG0142	geranyltranstransferase activity
E3D14_17165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3D14_17190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3D14_17195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3D14_17200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3D14_17205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3D14_17220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3D14_17220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3D14_17225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3D14_17240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3D14_17260	COG3381	protein complex oligomerization
E3D14_17290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3D14_17295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3D14_17300	COG0511	ligase activity, forming carbon-carbon bonds
E3D14_17305	COG0439	Biotin carboxylase
E3D14_17310	COG3924	membrane
E3D14_17315	COG4145	pantothenate transmembrane transporter activity
E3D14_17320	COG1263	PTS System
E3D14_17320	COG2190	(PTS) system
E3D14_17320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3D14_17325	COG0583	DNA-binding transcription factor activity
E3D14_17330	COG0604	alcohol dehydrogenase
E3D14_17335	COG2264	protein methyltransferase activity
E3D14_17345	COG4303	Ethanolamine ammonia lyase large subunit
E3D14_17350	COG4302	ethanolamine ammonia-lyase activity
E3D14_17370	COG0778	Nitroreductase
E3D14_17375	COG1902	pentaerythritol trinitrate reductase activity
E3D14_17375	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3D14_17380	COG0616	signal peptide processing
E3D14_17400	COG3139	Protein of unknown function (DUF1315)
E3D14_17405	COG0252	asparaginase activity
E3D14_17410	COG0786	glutamate:sodium symporter activity
E3D14_17425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3D14_17430	COG0384	phenazine biosynthesis protein PhzF
E3D14_17445	COG0175	sulfate reduction
E3D14_17450	COG2113	Glycine betaine
E3D14_17455	COG4176	ABC-type proline glycine betaine transport system permease component
E3D14_17460	COG4175	Glycine betaine
E3D14_17470	COG3610	response to peptide
E3D14_17475	COG2966	Psort location CytoplasmicMembrane, score
E3D14_17485	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3D14_17495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3D14_17500	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_17510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3D14_17535	COG2986	histidine ammonia-lyase
E3D14_17550	COG0318	PFAM AMP-dependent synthetase and ligase
E3D14_17560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3D14_17565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3D14_17600	COG1858	cytochrome C peroxidase
E3D14_17610	COG2313	pseudouridylate synthase activity
E3D14_17615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3D14_17615	COG1522	sequence-specific DNA binding
E3D14_17645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3D14_17650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3D14_17665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E3D14_17680	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3D14_17690	COG4608	Belongs to the ABC transporter superfamily
E3D14_17695	COG0444	Belongs to the ABC transporter superfamily
E3D14_17700	COG0747	negative chemotaxis
E3D14_17705	COG4239	(ABC) transporter, permease
E3D14_17715	COG4206	TonB-dependent receptor
E3D14_17725	COG0811	peptide transport
E3D14_17730	COG0811	peptide transport
E3D14_17735	COG0848	biopolymer transport protein
E3D14_17780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3D14_17785	COG0840	transmembrane signaling receptor activity
E3D14_17795	COG1278	Cold shock
E3D14_17825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3D14_17835	COG0688	phosphatidylethanolamine metabolic process
E3D14_17840	COG4628	conserved protein (DUF2132)
E3D14_17860	COG5001	Diguanylate cyclase
E3D14_17860	COG3300	MHYT domain
E3D14_17865	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E3D14_17870	COG3291	Pkd domain containing protein
E3D14_17870	COG4412	M6 family metalloprotease domain protein
E3D14_17900	COG1012	belongs to the aldehyde dehydrogenase family
E3D14_17915	COG1132	(ABC) transporter
E3D14_17925	COG2897	thiosulfate sulfurtransferase activity
E3D14_17930	COG2066	Belongs to the glutaminase family
E3D14_17935	COG3171	Protein conserved in bacteria
E3D14_17940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3D14_17955	COG2200	EAL domain
E3D14_17960	COG1090	epimerase
E3D14_17965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3D14_17970	COG4181	ATPase activity
E3D14_17975	COG2755	lipolytic protein G-D-S-L family
E3D14_17980	COG0784	Response regulator, receiver
E3D14_17980	COG0835	chemotaxis
E3D14_17990	COG0569	domain protein
E3D14_17990	COG2985	domain, Protein
E3D14_17995	COG1272	protein, Hemolysin III
E3D14_18000	COG0076	glutamate decarboxylase activity
E3D14_18005	COG2917	probably involved in intracellular septation
E3D14_18010	COG2350	Protein conserved in bacteria
E3D14_18020	COG1555	photosystem II stabilization
E3D14_18025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3D14_18030	COG3104	oligopeptide transport
E3D14_18035	COG0745	RESPONSE REGULATOR receiver
E3D14_18065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3D14_18080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E3D14_18085	COG1280	lysine exporter protein (LysE YggA)
E3D14_18115	COG0316	Belongs to the HesB IscA family
E3D14_18125	COG0038	chloride channel
E3D14_18130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3D14_18145	COG0671	phosphoesterase, PA-phosphatase related
E3D14_18155	COG3437	response regulator, receiver
E3D14_18155	COG0784	Response regulator, receiver
E3D14_18160	COG0583	DNA-binding transcription factor activity
E3D14_18165	COG2076	Multidrug Resistance protein
E3D14_18175	COG0346	lactoylglutathione lyase activity
E3D14_18180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3D14_18185	COG1643	Atp-dependent helicase
E3D14_18195	COG1489	DNA binding
E3D14_18200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3D14_18205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3D14_18210	COG0617	tRNA 3'-terminal CCA addition
E3D14_18215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3D14_18220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3D14_18225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3D14_18235	COG0842	Transport permease protein
E3D14_18240	COG1131	(ABC) transporter
E3D14_18255	COG0163	prenyltransferase activity
E3D14_18260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3D14_18265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3D14_18270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3D14_18280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3D14_18280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3D14_18280	COG0506	proline dehydrogenase activity
E3D14_18285	COG4991	sh3 domain protein
E3D14_18290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3D14_18310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3D14_18315	COG1640	4-alpha-glucanotransferase
E3D14_18320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3D14_18325	COG0676	glucose-6-phosphate 1-epimerase activity
E3D14_18330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3D14_18400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3D14_18405	COG2885	chlorophyll binding
E3D14_18410	COG0823	Involved in the tonB-independent uptake of proteins
E3D14_18425	COG0811	peptide transport
E3D14_18430	COG0824	Thioesterase
E3D14_18435	COG3790	cyd operon protein YbgE
E3D14_18440	COG4890	Cyd operon protein YbgT
E3D14_18445	COG1294	oxidase, subunit
E3D14_18450	COG1271	oxidase subunit
E3D14_18455	COG2255	four-way junction helicase activity
E3D14_18460	COG0632	four-way junction helicase activity
E3D14_18465	COG0840	transmembrane signaling receptor activity
E3D14_18470	COG0442	prolyl-tRNA aminoacylation
E3D14_18480	COG1902	pentaerythritol trinitrate reductase activity
E3D14_18490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3D14_18495	COG0745	RESPONSE REGULATOR receiver
E3D14_18495	COG3706	GGDEF domain
E3D14_18520	COG0714	Associated with various cellular activities
E3D14_18530	COG0456	acetyltransferase
E3D14_18540	COG1022	Amp-dependent synthetase and ligase
E3D14_18550	COG2918	glutathione biosynthetic process
E3D14_18555	COG0612	Peptidase, M16
E3D14_18560	COG1238	metal cluster binding
E3D14_18565	COG1064	alcohol dehydrogenase
E3D14_18595	COG0359	binds to the 23S rRNA
E3D14_18600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3D14_18605	COG0360	Binds together with S18 to 16S ribosomal RNA
E3D14_18610	COG1914	H( )-stimulated, divalent metal cation uptake system
E3D14_18630	COG2153	protein acetylation
E3D14_18640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3D14_18645	COG0557	exoribonuclease II activity
E3D14_18650	COG3706	GGDEF domain
E3D14_18655	COG1854	S-ribosylhomocysteine lyase activity
E3D14_18670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3D14_18670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3D14_18705	COG4968	Prepilin-type N-terminal cleavage methylation domain
E3D14_18710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3D14_18715	COG1047	Peptidyl-prolyl cis-trans
E3D14_18720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3D14_18725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3D14_18730	COG0196	riboflavin kinase activity
E3D14_18735	COG0728	peptidoglycan biosynthetic process
E3D14_18740	COG0268	Binds directly to 16S ribosomal RNA
E3D14_18745	COG0640	Transcriptional regulator
E3D14_18750	COG0583	DNA-binding transcription factor activity
E3D14_18760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3D14_18765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3D14_18770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3D14_18780	COG1051	belongs to the nudix hydrolase family
E3D14_18785	COG3066	DNA modification
E3D14_18795	COG0335	large ribosomal subunit rRNA binding
E3D14_18800	COG0336	Belongs to the RNA methyltransferase TrmD family
E3D14_18805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3D14_18810	COG0228	four-way junction DNA binding
E3D14_18815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3D14_18820	COG4137	Cytochrome C assembly protein
E3D14_18825	COG4536	flavin adenine dinucleotide binding
E3D14_18830	COG1959	2 iron, 2 sulfur cluster binding
E3D14_18835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3D14_18835	COG1017	nitric oxide dioxygenase activity
E3D14_18840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3D14_18845	COG0039	L-malate dehydrogenase activity
E3D14_18850	COG4160	amino acid transport
E3D14_18855	COG4215	(ABC) transporter
E3D14_18860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_18865	COG1126	abc transporter atp-binding protein
E3D14_18870	COG1438	arginine binding
E3D14_18875	COG2837	iron assimilation
E3D14_18880	COG3842	ATPase activity
E3D14_18890	COG1840	ABC-type Fe3 transport system, periplasmic component
E3D14_18895	COG0347	Belongs to the P(II) protein family
E3D14_18910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3D14_18930	COG1929	Belongs to the glycerate kinase type-1 family
E3D14_18935	COG2610	gluconate transmembrane transporter activity
E3D14_18935	COG2610	gluconate transmembrane transporter activity
E3D14_18940	COG3835	regulator
E3D14_18945	COG3112	Uncharacterised protein family (UPF0231)
E3D14_18960	COG0840	transmembrane signaling receptor activity
E3D14_18965	COG3568	Endonuclease Exonuclease Phosphatase
E3D14_18980	COG0513	Belongs to the DEAD box helicase family
E3D14_19020	COG1448	Aminotransferase
E3D14_19035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3D14_19040	COG1328	CTP reductase activity
E3D14_19075	COG1215	transferase activity, transferring glycosyl groups
E3D14_19115	COG0840	transmembrane signaling receptor activity
E3D14_19120	COG3397	chitin binding
E3D14_19125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_19130	COG1126	abc transporter atp-binding protein
E3D14_19140	COG0765	amino acid transport
E3D14_19145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3D14_19150	COG0583	DNA-binding transcription factor activity
E3D14_19155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3D14_19160	COG4208	sulfate ABC transporter
E3D14_19165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3D14_19175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3D14_19180	COG3174	membrane
E3D14_19185	COG0110	maltose O-acetyltransferase activity
E3D14_19215	COG1942	4-Oxalocrotonate Tautomerase
E3D14_19225	COG0583	DNA-binding transcription factor activity
E3D14_19230	COG0165	Argininosuccinate lyase
E3D14_19235	COG0137	argininosuccinate synthase activity
E3D14_19245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3D14_19250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3D14_19260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E3D14_19270	COG2072	flavoprotein involved in K transport
E3D14_19280	COG1393	Belongs to the ArsC family
E3D14_19285	COG0798	PFAM Bile acid sodium symporter
E3D14_19305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3D14_19325	COG3068	Protein conserved in bacteria
E3D14_19335	COG0739	heme binding
E3D14_19355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3D14_19360	COG1121	(ABC) transporter
E3D14_19365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3D14_19370	COG0583	DNA-binding transcription factor activity
E3D14_19380	COG1573	uracil-dna glycosylase
E3D14_19385	COG2962	Rard protein
E3D14_19395	COG2827	Endonuclease containing a URI domain
E3D14_19410	COG1842	Phage shock protein A
E3D14_19415	COG0204	Acyl-transferase
E3D14_19435	COG3118	belongs to the thioredoxin family
E3D14_19440	COG2259	Doxx family
E3D14_19485	COG0187	DNA topoisomerase II activity
E3D14_19495	COG1051	belongs to the nudix hydrolase family
E3D14_19500	COG3150	esterase
E3D14_19510	COG3151	Protein conserved in bacteria
E3D14_19520	COG0494	nUDIX hydrolase
E3D14_19530	COG1538	Outer membrane efflux protein
E3D14_19535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3D14_19535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3D14_19540	COG1560	Kdo2-lipid A biosynthetic process
E3D14_19555	COG1392	Phosphate transport regulator
E3D14_19560	COG0306	phosphate transporter
E3D14_19565	COG0617	tRNA 3'-terminal CCA addition
E3D14_19570	COG3267	Type II secretory pathway component ExeA
E3D14_19570	COG3409	Peptidoglycan-binding domain 1 protein
E3D14_19580	COG1194	a g-specific adenine glycosylase
E3D14_19585	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E3D14_19595	COG3111	PFAM Bacterial OB fold (BOF) protein
E3D14_19600	COG3240	lipase activity
E3D14_19615	COG3009	Protein conserved in bacteria
E3D14_19620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3D14_19620	COG3008	intermembrane lipid transfer
E3D14_19625	COG2995	paraquat-inducible protein a
E3D14_19635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3D14_19650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3D14_19655	COG2813	Specifically methylates the guanine in position
E3D14_19660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3D14_19665	COG0297	glycogen (starch) synthase activity
E3D14_19705	COG1757	Na H antiporter
E3D14_19715	COG0110	maltose O-acetyltransferase activity
E3D14_19720	COG0366	Alpha amylase catalytic
E3D14_19740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3D14_19745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3D14_19750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3D14_19755	COG2723	6-phospho-beta-galactosidase activity
E3D14_19760	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3D14_19765	COG1940	carbohydrate kinase activity
E3D14_19775	COG1609	Transcriptional regulator
E3D14_19785	COG0252	asparaginase activity
E3D14_19800	COG1803	Methylglyoxal synthase
E3D14_19825	COG1444	tRNA N-acetyltransferase activity
E3D14_19830	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_19835	COG0784	Response regulator, receiver
E3D14_19835	COG0835	chemotaxis
E3D14_19955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3D14_19960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3D14_19975	COG0477	Major facilitator Superfamily
E3D14_19980	COG0523	cobalamin synthesis protein
E3D14_19990	COG1280	lysine exporter protein (LysE YggA)
E3D14_20000	COG0583	DNA-binding transcription factor activity
E3D14_20005	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_20010	COG2200	EAL domain
E3D14_20015	COG1049	propionate catabolic process, 2-methylcitrate cycle
E3D14_20030	COG0840	transmembrane signaling receptor activity
E3D14_20040	COG3447	MASE1 domain protein
E3D14_20040	COG5001	Diguanylate cyclase
E3D14_20040	COG5002	protein histidine kinase activity
E3D14_20045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3D14_20050	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3D14_20055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3D14_20060	COG2186	Transcriptional regulator
E3D14_20085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3D14_20095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3D14_20105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E3D14_20110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3D14_20115	COG0494	nUDIX hydrolase
E3D14_20125	COG0653	protein targeting
E3D14_20135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3D14_20140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3D14_20145	COG0849	cell division
E3D14_20150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3D14_20155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3D14_20160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3D14_20165	COG0772	Belongs to the SEDS family
E3D14_20170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3D14_20175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3D14_20180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3D14_20190	COG0768	penicillin binding
E3D14_20195	COG3116	cell division
E3D14_20200	COG0275	rRNA processing
E3D14_20205	COG2001	Belongs to the MraZ family
E3D14_20215	COG0741	lytic transglycosylase activity
E3D14_20215	COG1388	LysM domain
E3D14_20225	COG1360	Flagellar Motor Protein
E3D14_20230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3D14_20235	COG1191	sigma factor activity
E3D14_20260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E3D14_20275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3D14_20295	COG1256	bacterial-type flagellum assembly
E3D14_20305	COG1706	bacterial-type flagellum-dependent cell motility
E3D14_20310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E3D14_20315	COG4786	Flagellar basal body rod
E3D14_20320	COG4786	Flagellar basal body rod
E3D14_20325	COG1749	Flagellar hook protein flgE
E3D14_20335	COG1558	bacterial-type flagellum-dependent cell motility
E3D14_20340	COG1815	bacterial-type flagellum-dependent cell motility
E3D14_20350	COG2747	anti-sigma28 factor FlgM
E3D14_20375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3D14_20385	COG1677	Flagellar hook-basal body complex protein FliE
E3D14_20390	COG2204	response regulator
E3D14_20410	COG1987	bacterial-type flagellum assembly
E3D14_20435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3D14_20440	COG3107	peptidoglycan biosynthetic process
E3D14_20450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3D14_20455	COG2823	Periplasmic or secreted lipoprotein
E3D14_20460	COG2969	positive regulation of protein catabolic process
E3D14_20465	COG0625	glutathione transferase activity
E3D14_20470	COG2857	Cytochrome c1
E3D14_20475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3D14_20480	COG0723	plastoquinol--plastocyanin reductase activity
E3D14_20485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3D14_20490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3D14_20495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3D14_20505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3D14_20510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3D14_20545	COG3964	amidohydrolase
E3D14_20565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_20570	COG1660	Displays ATPase and GTPase activities
E3D14_20575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3D14_20585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3D14_20590	COG1137	ATPase activity
E3D14_20595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3D14_20600	COG3117	lipopolysaccharide transmembrane transporter activity
E3D14_20605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3D14_20610	COG0517	IMP dehydrogenase activity
E3D14_20610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3D14_20615	COG1127	ABC transporter
E3D14_20620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3D14_20625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3D14_20630	COG2854	intermembrane phospholipid transfer
E3D14_20640	COG5007	Belongs to the BolA IbaG family
E3D14_20645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3D14_20650	COG0312	modulator of DNA gyrase
E3D14_20655	COG3028	Belongs to the UPF0307 family
E3D14_20665	COG2926	Belongs to the UPF0265 family
E3D14_20690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3D14_20695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3D14_20700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3D14_20705	COG0049	tRNA binding
E3D14_20710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3D14_20715	COG2168	tRNA wobble position uridine thiolation
E3D14_20720	COG2923	Belongs to the DsrF TusC family
E3D14_20735	COG2964	Protein conserved in bacteria
E3D14_20740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3D14_20745	COG0085	RNA polymerase activity
E3D14_20750	COG0222	ribosome binding
E3D14_20755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3D14_20760	COG0081	regulation of translation
E3D14_20765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3D14_20770	COG0250	Participates in transcription elongation, termination and antitermination
E3D14_20775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3D14_20785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3D14_20810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3D14_20815	COG0569	domain protein
E3D14_20820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3D14_20825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3D14_20830	COG3005	denitrification pathway
E3D14_20835	COG0243	molybdopterin cofactor binding
E3D14_20845	COG2205	protein histidine kinase activity
E3D14_20850	COG0745	RESPONSE REGULATOR receiver
E3D14_20865	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E3D14_20870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3D14_20885	COG2204	response regulator
E3D14_20895	COG2205	protein histidine kinase activity
E3D14_20910	COG1028	Short-chain dehydrogenase reductase Sdr
E3D14_20915	COG0516	GMP reductase activity
E3D14_20915	COG0517	IMP dehydrogenase activity
E3D14_20930	COG1522	sequence-specific DNA binding
E3D14_20935	COG2502	aspartate--ammonia ligase
E3D14_20940	COG0542	response to heat
E3D14_20950	COG0564	pseudouridine synthase activity
E3D14_20955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3D14_20960	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3D14_20970	COG3681	Belongs to the UPF0597 family
E3D14_20975	COG2964	Protein conserved in bacteria
E3D14_20985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3D14_20990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3D14_20995	COG1979	alcohol dehydrogenase
E3D14_21005	COG3040	lipid binding
E3D14_21015	COG0688	phosphatidylethanolamine metabolic process
E3D14_21030	COG0540	Belongs to the ATCase OTCase family
E3D14_21035	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E3D14_21045	COG1288	antiporter activity
E3D14_21050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3D14_21105	COG1609	Transcriptional regulator
E3D14_21110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3D14_21120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3D14_21125	COG2017	converts alpha-aldose to the beta-anomer
E3D14_21130	COG0667	Aldo Keto reductase
E3D14_21135	COG1968	undecaprenyl-diphosphatase activity
E3D14_21145	COG1595	DNA-templated transcription, initiation
E3D14_21155	COG0018	arginyl-trna synthetase
E3D14_21165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E3D14_21170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E3D14_21185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3D14_21190	COG2146	nitrite reductase [NAD(P)H] activity
E3D14_21195	COG2116	formate transmembrane transporter activity
E3D14_21200	COG1648	precorrin-2 dehydrogenase activity
E3D14_21200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3D14_21205	COG2239	Acts as a magnesium transporter
E3D14_21220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3D14_21225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3D14_21235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3D14_21245	COG0514	ATP-dependent DNA helicase (RecQ)
E3D14_21250	COG2050	protein possibly involved in aromatic compounds catabolism
E3D14_21265	COG2258	MOSC domain
E3D14_21270	COG1177	transmembrane transport
E3D14_21275	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3D14_21280	COG3842	ATPase activity
E3D14_21300	COG0174	glutamine synthetase
E3D14_21305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3D14_21315	COG3045	CreA protein
E3D14_21320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3D14_21325	COG0443	Heat shock 70 kDa protein
E3D14_21340	COG0366	Alpha amylase catalytic
E3D14_21345	COG1086	Polysaccharide biosynthesis protein
E3D14_21365	COG1442	glycosyl transferase family 8
E3D14_21385	COG0318	PFAM AMP-dependent synthetase and ligase
E3D14_21405	COG1083	cytidylyl-transferase
E3D14_21415	COG2089	acid synthase
E3D14_21480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3D14_21485	COG0745	RESPONSE REGULATOR receiver
E3D14_21490	COG2205	protein histidine kinase activity
E3D14_21500	COG0281	malic enzyme
E3D14_21505	COG0702	epimerase
E3D14_21510	COG0254	rRNA binding
E3D14_21515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3D14_21525	COG1309	transcriptional regulator
E3D14_21545	COG0129	dihydroxy-acid dehydratase activity
E3D14_21550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3D14_21555	COG3978	acetolactate synthase activity
E3D14_21575	COG0204	Acyl-transferase
E3D14_21580	COG1683	Conserved Protein
E3D14_21590	COG1335	isochorismatase
E3D14_21600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E3D14_21605	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3D14_21610	COG3639	organic phosphonate transmembrane transporter activity
E3D14_21615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3D14_21620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3D14_21630	COG3084	Protein conserved in bacteria
E3D14_21635	COG2203	Gaf domain
E3D14_21635	COG3706	GGDEF domain
E3D14_21635	COG5001	Diguanylate cyclase
E3D14_21635	COG4251	negative regulation of phosphorylation
E3D14_21650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3D14_21660	COG1561	YicC-like family, N-terminal region
E3D14_21690	COG0438	transferase activity, transferring glycosyl groups
E3D14_21695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3D14_21710	COG1063	alcohol dehydrogenase
E3D14_21725	COG0210	DNA helicase
E3D14_21730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3D14_21735	COG2166	iron-sulfur cluster assembly
E3D14_21740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3D14_21770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E3D14_21775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3D14_21780	COG1739	Uncharacterized protein family UPF0029
E3D14_21785	COG0006	proline dipeptidase activity
E3D14_21790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3D14_21795	COG1024	Enoyl-CoA hydratase
E3D14_21795	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3D14_21800	COG0183	Belongs to the thiolase family
E3D14_21805	COG0745	RESPONSE REGULATOR receiver
E3D14_21810	COG2205	protein histidine kinase activity
E3D14_21825	COG0425	Belongs to the sulfur carrier protein TusA family
E3D14_21830	COG0251	oxidation-reduction process
E3D14_21835	COG2885	chlorophyll binding
E3D14_21840	COG2818	Glycosylase
E3D14_21845	COG0752	glycyl-tRNA synthetase alpha subunit
E3D14_21850	COG0751	glycine-tRNA ligase activity
E3D14_21860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3D14_21870	COG2202	Pas domain
E3D14_21870	COG2200	EAL domain
E3D14_21870	COG2199	diguanylate cyclase activity
E3D14_21885	COG0814	amino acid
E3D14_21890	COG0348	domain, Protein
E3D14_21900	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3D14_21905	COG1773	rubredoxin
E3D14_21905	COG0426	domain, Protein
E3D14_21910	COG3604	Transcriptional regulator
E3D14_21915	COG2188	Transcriptional regulator
E3D14_21930	COG1609	Transcriptional regulator
E3D14_21940	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3D14_21970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3D14_21995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3D14_22005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3D14_22010	COG3118	belongs to the thioredoxin family
E3D14_22015	COG0513	Belongs to the DEAD box helicase family
E3D14_22020	COG0248	Ppx GppA phosphatase
E3D14_22030	COG0742	ribosomal rna small subunit methyltransferase
E3D14_22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3D14_22055	COG0084	hydrolase, TatD family'
E3D14_22060	COG0805	protein transport
E3D14_22065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3D14_22075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3D14_22080	COG3165	ubiquinone biosynthetic process from chorismate
E3D14_22090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3D14_22135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E3D14_22140	COG0848	biopolymer transport protein
E3D14_22145	COG0811	peptide transport
E3D14_22150	COG0811	peptide transport
E3D14_22160	COG2771	luxR family
E3D14_22190	COG1484	DNA-dependent DNA replication
E3D14_22195	COG4584	PFAM Integrase catalytic
E3D14_22250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3D14_22255	COG1349	DNA-binding transcription factor activity
E3D14_22260	COG0745	RESPONSE REGULATOR receiver
E3D14_22265	COG2205	protein histidine kinase activity
E3D14_22275	COG4452	Inner membrane protein CreD
E3D14_22280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3D14_22285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3D14_22290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3D14_22295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3D14_22300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3D14_22305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3D14_22310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3D14_22320	COG0356	it plays a direct role in the translocation of protons across the membrane
E3D14_22325	COG3312	ion transport
E3D14_22330	COG1475	DNA binding
E3D14_22335	COG1192	Involved in chromosome partitioning
E3D14_22340	COG0357	Ribosomal RNA small subunit methyltransferase G
E3D14_22345	COG0445	tRNA wobble uridine modification
E3D14_22350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3D14_22355	COG4774	siderophore transport
E3D14_22360	COG4615	Cyclic peptide transporter
E3D14_22365	COG1120	ATPase activity
E3D14_22370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3D14_22380	COG4774	siderophore transport
E3D14_22385	COG4607	ABC-type enterochelin transport system periplasmic component
E3D14_22390	COG4604	ABC transporter, ATP-binding protein
E3D14_22395	COG4605	iron ion homeostasis
E3D14_22400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3D14_22420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3D14_22430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3D14_22445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3D14_22450	COG0706	membrane insertase activity
E3D14_22455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3D14_22460	COG0594	ribonuclease P activity
E3D14_22465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3D14_22490	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3D14_22500	COG1192	Involved in chromosome partitioning
E3D14_22510	COG3328	transposase activity
E3D14_22540	COG0393	Putative heavy-metal-binding
E3D14_22565	COG1484	DNA-dependent DNA replication
E3D14_22570	COG4584	PFAM Integrase catalytic
E3D14_22600	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3D14_22615	COG1192	Involved in chromosome partitioning
E3D14_22740	COG3328	transposase activity
E3D14_22770	COG1317	bacterial-type flagellum organization
E3D14_22860	COG0457	Tetratricopeptide repeat
E3D14_22925	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3D14_22930	COG4790	Type iii secretion
E3D14_22935	COG4794	Type iii secretion
E3D14_22940	COG4791	protein targeting
E3D14_22945	COG4792	protein secretion
E3D14_22975	COG3328	transposase activity
E3D14_22980	COG1484	DNA-dependent DNA replication
E3D14_22985	COG4584	PFAM Integrase catalytic
E3D14_23105	COG3039	Transposase
E3D14_23130	COG3316	Transposase and inactivated derivatives
E3D14_23185	COG0583	DNA-binding transcription factor activity
E3D14_23250	COG0697	spore germination
E3D14_23335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3D14_23400	COG2003	Belongs to the UPF0758 family
E3D14_23440	COG4584	PFAM Integrase catalytic
E3D14_23445	COG1484	DNA-dependent DNA replication
E3D14_23475	COG2194	sulfuric ester hydrolase activity
E3D14_23480	COG2194	sulfuric ester hydrolase activity
E3D14_23490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3D14_23500	COG1192	Involved in chromosome partitioning
E3D14_23530	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3D14_23725	COG2003	Belongs to the UPF0758 family
E3D14_23770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3D14_23825	COG0489	protein tyrosine kinase activity
E3D14_23840	COG2826	transposase and inactivated derivatives, IS30 family
E3D14_23900	COG4771	TonB-dependent receptor
E3D14_23900	COG1629	transport