locus-tag class description WL1483_10 ENOG4105DJ4 phosphatidylserine decarboxylase WL1483_1000 ENOG4105K70 DNA-binding protein WL1483_1005 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WL1483_1006 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WL1483_1007 ENOG4105CHM Aminotransferase WL1483_1008 ENOG4107308 Uncharacterized protein conserved in bacteria (DUF2057) WL1483_1012 ENOG4108I6A alcohol dehydrogenase WL1483_1013 ENOG4107SDU Methyl-accepting chemotaxis WL1483_1016 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) WL1483_1017 ENOG4105EJG cellulose synthase WL1483_1019 ENOG4105ECP epimerase WL1483_102 ENOG4105CR8 Transcriptional regulator WL1483_1023 ENOG4108KW7 amp-dependent synthetase and ligase WL1483_1026 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WL1483_1027 ENOG4105VIE preprotein translocase, subunit YajC WL1483_1028 ENOG4105BZU Histidine kinase WL1483_103 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) WL1483_1030 ENOG4105E33 succinate dehydrogenase WL1483_1031 ENOG4105NXV High-affinity zinc uptake system protein WL1483_1033 ENOG4107SC1 transglycosylase WL1483_1036 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) WL1483_1037 ENOG4107QP8 phosphohexose isomerase WL1483_104 ENOG4105DND Transcriptional regulator WL1483_1040 ENOG4105C4M (Ubiquinol oxidase) subunit I WL1483_1043 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WL1483_1046 ENOG4108M6U Universal stress protein A WL1483_1047 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase WL1483_1048 ENOG4105C8T Leucyl-tRNA synthetase WL1483_1049 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 WL1483_1050 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WL1483_1051 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) WL1483_1052 ENOG4108KHX Diguanylate cyclase WL1483_1053 ENOG4108WC9 type VI secretion system effector, hcp1 family WL1483_1054 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WL1483_1055 ENOG4108JQC penicillin-binding protein 1A WL1483_1057 ENOG4105CMR udp-glucose 4-epimerase WL1483_1059 ENOG4108IEG Formate dehydrogenase Alpha subunit WL1483_1059 ENOG4108IEG Formate dehydrogenase Alpha subunit WL1483_106 ENOG41087AY ADP-Ribose pyrophosphatase WL1483_1061 ENOG4108WC9 type VI secretion system effector, hcp1 family WL1483_1065 ENOG4105GVR general secretion pathway protein D WL1483_1067 ENOG4107TYH extracellular solute-binding protein family 1 WL1483_1068 ENOG4105BZE flagellar hook protein, FlgE WL1483_1069 ENOG4108ZC9 flagellar basal-body rod protein flgc WL1483_1072 ENOG4107IFA Lipase (EC 3.1.1.3) WL1483_108 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WL1483_1081 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit WL1483_1085 ENOG4105CUC YeeE YedE family protein WL1483_1086 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WL1483_1087 ENOG41090JE Utilization Protein WL1483_1088 ENOG4107QNR UPF0135 protein WL1483_1090 ENOG4105CKW Inner membrane protein yedI WL1483_1096 ENOG4105DK0 Indole-3-glycerol phosphate synthase WL1483_1097 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase WL1483_1098 ENOG4105CNG UPF0061 protein WL1483_1099 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase WL1483_11 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_1100 ENOG4105VN1 Heat shock protein WL1483_1101 ENOG4108ZJT translation initiation factor, Sui1 WL1483_1102 ENOG4105D7B Flagellar biosynthesis protein flha WL1483_1105 ENOG4105I93 response regulator WL1483_1106 ENOG4105XJC Two component transcriptional regulator (Winged helix family WL1483_1107 ENOG4107V9H nitrite transporter WL1483_1109 ENOG4105D07 Signal peptide peptidase, SppA WL1483_1110 ENOG4105EQR Transposase IS116 IS110 IS902 WL1483_1111 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) WL1483_1113 ENOG41065SU Two-component system sensor kinase WL1483_1114 ENOG4105E98 transcriptional regulator DeoR family WL1483_1115 ENOG4105CGP Urocanate hydratase WL1483_1117 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB WL1483_1118 ENOG4108ZQS transposase WL1483_1121 ENOG4105BZU Histidine kinase WL1483_1122 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) WL1483_1123 ENOG41069D7 Methyl-accepting chemotaxis WL1483_1125 ENOG4105MH2 YfcL protein WL1483_1127 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) WL1483_1128 ENOG4105CGH 5'-nucleotidase WL1483_1129 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) WL1483_113 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WL1483_1130 ENOG4105F0R Cytidylyltransferase WL1483_1131 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WL1483_1137 ENOG4105FAV ABC, transporter WL1483_1138 ENOG4108V1T peptidylprolyl cis-trans isomerase WL1483_114 ENOG4105Y75 tpr repeat protein WL1483_1142 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WL1483_1144 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WL1483_1146 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_1147 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WL1483_1148 ENOG410624X efflux transporter, rnd family, mfp subunit WL1483_115 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) WL1483_1152 ENOG4105GKE subunit e WL1483_1153 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WL1483_1154 ENOG4108TEB UPF0114 protein WL1483_1155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WL1483_1158 ENOG4105EIY sodium-type flagellar protein motY WL1483_1165 ENOG4108MVM Transposase WL1483_1167 ENOG4105CFC Transporter WL1483_1168 ENOG4105JIM Phosphatidylserine synthase WL1483_1169 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) WL1483_117 ENOG4108IA2 Sodium pantothenate symporter WL1483_1174 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase WL1483_1176 ENOG4107QX3 carboxylase WL1483_1177 ENOG4105M7P phage repressor WL1483_1178 ENOG4107PE3 Mammalian cell entry related domain protein WL1483_1179 ENOG4107QJE Chromosome Partitioning Protein WL1483_118 ENOG41063Z6 transcriptional regulator, lysR family WL1483_1182 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component WL1483_1184 ENOG4108ZQS transposase WL1483_1185 ENOG4105E39 Enoyl-CoA hydratase WL1483_1188 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) WL1483_119 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) WL1483_1191 ENOG4105XPH Ferredoxin WL1483_1192 ENOG41060NJ transcriptional regulator WL1483_1194 ENOG4105JKW Valine--pyruvate aminotransferase WL1483_1195 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WL1483_1196 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) WL1483_1197 ENOG4108JEH abc transporter atp-binding protein WL1483_1199 ENOG4108J1Q WL1483_12 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) WL1483_120 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_1202 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) WL1483_1203 ENOG4107S2Z UPF0761 membrane protein WL1483_1205 ENOG4105K63 Thioredoxin WL1483_1206 ENOG4105CDH Citrulline--aspartate ligase WL1483_1207 ENOG4107T0K Adenylate cyclase WL1483_1209 ENOG4105HF0 Membrane WL1483_1210 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) WL1483_1211 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WL1483_1213 ENOG4107QKA exodeoxyribonuclease V beta WL1483_1216 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WL1483_1217 ENOG41082RQ UPF0102 protein WL1483_1218 ENOG4105CHU acetyl-coa acetyltransferase WL1483_1219 ENOG4108EUD Lysophospholipase WL1483_122 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WL1483_1220 ENOG4108J1Q WL1483_1224 ENOG4105UYK outer membrane protein a WL1483_1227 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein WL1483_1228 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WL1483_1229 ENOG4108I0Y (ABC) transporter WL1483_123 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WL1483_1230 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) WL1483_1233 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WL1483_1234 ENOG4108MVM Transposase WL1483_1235 ENOG4108UTZ Dihydroxyacetone kinase WL1483_1236 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WL1483_1237 ENOG4107ESN Flagella basal body P-ring formation protein flgA WL1483_1239 ENOG4108UUE Transcriptional regulator WL1483_124 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) WL1483_1241 ENOG4105CJN penicillin-binding protein WL1483_1243 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor WL1483_1246 ENOG4108T86 baseplate J family protein WL1483_1247 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WL1483_1248 ENOG4105BZU Histidine kinase WL1483_1250 ENOG4108SZ7 secretion system effector WL1483_1253 ENOG4105XJC Two component transcriptional regulator (Winged helix family WL1483_1255 ENOG4105C26 Dehydrogenase WL1483_1257 ENOG4105DWK Membrane WL1483_1258 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WL1483_1260 ENOG4108WBT adenosyltransferase WL1483_1262 ENOG4105D05 Receptor WL1483_1263 ENOG4108M1A Chitin-binding protein WL1483_1266 ENOG4108IUF type iii secretion WL1483_1267 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WL1483_1268 ENOG4105W0E 50S ribosomal protein L33 WL1483_1269 ENOG4105DVI reductase, NrfD WL1483_127 ENOG4105CQ7 ATP-dependent helicase WL1483_1271 ENOG4105DZC cytosine deaminase WL1483_1274 ENOG4108J1Q WL1483_1277 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WL1483_1278 ENOG4105E0A ABC, transporter WL1483_1279 ENOG4105HEI LysR family (Transcriptional regulator WL1483_1280 ENOG4107QHF type ii secretion system protein e WL1483_1282 ENOG4105DY9 regulatoR WL1483_1284 ENOG4105CQC Prephenate dehydratase WL1483_1288 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) WL1483_1291 ENOG4105D60 lipoprotein releasing system transmembrane protein WL1483_1294 ENOG4108JCI Transcriptional regulator WL1483_1295 ENOG4108YZA Nitrogen regulatory protein pii WL1483_1296 ENOG4105BZN citrate synthase WL1483_1298 ENOG4105C26 Dehydrogenase WL1483_1299 ENOG4108S0S Nucleotidyl transferase WL1483_130 ENOG4105DR9 pseudouridine synthase WL1483_1300 ENOG4105EV4 Multidrug resistance protein mdtH WL1483_1301 ENOG4105C0P Mg chelatase subunit ChlI WL1483_1303 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WL1483_1306 ENOG4105BZU Histidine kinase WL1483_1307 ENOG4105CNU cell division protein FtsK WL1483_1308 ENOG4107EEX Cellulose synthase regulator protein WL1483_1309 ENOG4105E2R ROK family WL1483_131 ENOG4108SXK Transporter Drug Metabolite Exporter family WL1483_1310 ENOG4105VDB UPF0125 protein WL1483_1314 ENOG4108J1Q WL1483_1317 ENOG4105M4H endoribonuclease L-psp WL1483_1318 ENOG4105EYH Exonuclease WL1483_1319 ENOG4105CHV Transcription elongation factor NusA WL1483_132 ENOG41063JG Transcriptional regulator WL1483_1320 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WL1483_1321 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WL1483_1322 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WL1483_1323 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) WL1483_1325 ENOG4105DTN riboflavin biosynthesis protein ribF WL1483_1326 ENOG4105CPI Metal Dependent Phosphohydrolase WL1483_1327 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WL1483_133 ENOG4108NVR Methyl-accepting chemotaxis WL1483_1331 ENOG4105C9K Endothelin-converting enzyme 1 WL1483_1332 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WL1483_1334 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) WL1483_1336 ENOG4107QR9 Iron-sulfur cluster binding protein WL1483_1338 ENOG4108J1Q WL1483_1339 ENOG4105CYM Glutathione S-transferase WL1483_134 ENOG4105CBS Chea signal transduction histidine kinase WL1483_1342 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit WL1483_1343 ENOG4108J1Q WL1483_1347 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 WL1483_1348 ENOG4108VYJ response regulator receiver protein WL1483_1349 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WL1483_135 ENOG4105CNI cell division protein FtsW WL1483_1352 ENOG4105ETT transcriptional Regulator, LysR family WL1483_1353 ENOG4108RIR Molybdenum cofactor biosynthesis protein WL1483_1355 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) WL1483_1356 ENOG4105CFP Peptidase U32 WL1483_136 ENOG4107TH8 cina domain protein WL1483_1360 ENOG4105ETX regulatoR WL1483_1363 ENOG4105EIX cytochrome c1 WL1483_1364 ENOG41083MP 50s ribosomal protein l29 WL1483_1365 ENOG4105CJ1 ABC, transporter WL1483_1366 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WL1483_1367 ENOG4105D9U N-acetyltransferase WL1483_1368 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WL1483_1369 ENOG4105PC1 Conserved Protein WL1483_1370 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) WL1483_1372 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) WL1483_1373 ENOG4108Q5Y Membrane WL1483_1377 ENOG4105D06 uba thif-type nad fad binding protein WL1483_1378 ENOG4105EIP mannose-6-phosphate isomerase WL1483_138 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WL1483_1380 ENOG4105C5S asparaginyl-tRNA synthetase WL1483_1384 ENOG4108IJF Heavy metal efflux pump, CzcA WL1483_1385 ENOG4105DEF Extracellular solute-binding protein, family 5 WL1483_1387 ENOG4108N3W hemolysin secretion protein WL1483_1388 ENOG4105N21 Membrane WL1483_139 ENOG4107SQD Transcriptional regulator, GntR family WL1483_1391 ENOG4108RVA ribokinase WL1483_1392 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WL1483_1393 ENOG4106NZI LysR family Transcriptional regulator WL1483_1395 ENOG4105BZU Histidine kinase WL1483_1397 ENOG4105BZU Histidine kinase WL1483_1398 ENOG4108IYH Dna topoisomerase WL1483_1399 ENOG4107R88 Chemotaxis protein (CheV) WL1483_140 ENOG4105T0Z Conserved Protein WL1483_1400 ENOG4107TT5 NLP P60 protein WL1483_1403 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WL1483_1404 ENOG4105CF7 AraC family transcriptional regulator WL1483_1406 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) WL1483_1407 ENOG4108JPW Aminotransferase WL1483_1409 ENOG4105W00 Flagellar hook capping protein WL1483_1414 ENOG4105E3A (ABC) transporter WL1483_1417 ENOG4108J1Q WL1483_142 ENOG4108UTP (2Fe-2S)-binding domain protein WL1483_1427 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WL1483_1430 ENOG41073TP transcriptional regulator WL1483_1433 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_1434 ENOG4105M8F Biopolymer transport protein exbD tolR WL1483_1436 ENOG4108IJ9 (ABC) transporter WL1483_1437 ENOG4105C0H protease WL1483_1438 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component WL1483_1439 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WL1483_1440 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WL1483_1442 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) WL1483_1444 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) WL1483_1446 ENOG4105C84 Histidine ammonia-lyase WL1483_1448 ENOG4105VNH ABC transporter solute-binding protein WL1483_1451 ENOG4105CA9 Pyruvate kinase WL1483_1452 ENOG4105C8Y Acetylornithine aminotransferase WL1483_1454 ENOG4105C44 Serine transporter WL1483_146 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase WL1483_1462 ENOG4105C1J atp-dependent rna helicase WL1483_1464 ENOG4105HVQ Regulatory factor of maltose metabolism WL1483_1465 ENOG4105E33 succinate dehydrogenase WL1483_1466 ENOG4105BZS acriflavin resistance protein WL1483_1467 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WL1483_1469 ENOG4105VQ0 flagellar hook-basal body complex protein fliE WL1483_1472 ENOG4107MM9 BNR Asp-box repeat-containing protein WL1483_1475 ENOG4105D6J arsenicaL-resistance protein WL1483_1479 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) WL1483_148 ENOG4105BZS acriflavin resistance protein WL1483_1480 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr WL1483_1481 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WL1483_1482 ENOG4105C87 Aminotransferase class I and II WL1483_1483 ENOG4105C7N Xanthine uracil vitamin C permease WL1483_1484 ENOG4107SC7 Inner membrane transporter yjeM WL1483_1485 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WL1483_1486 ENOG4105C25 Primosomal protein n' WL1483_1487 ENOG4105CW7 secretion protein, HlyD family WL1483_1488 ENOG4108RR8 protoporphyrinogen oxidase WL1483_149 ENOG4105ED4 portal protein WL1483_1490 ENOG4108JQ1 Dehydrogenase WL1483_1492 ENOG4105IPI Membrane WL1483_1493 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate WL1483_1494 ENOG4106PG1 outer membrane usher protein WL1483_1495 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) WL1483_1496 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters WL1483_1498 ENOG4105C12 Phosphoribosylglycinamide synthetase WL1483_1499 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WL1483_15 ENOG4107R28 alpha amylase, catalytic region WL1483_1500 ENOG4105DWP Membrane WL1483_1501 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WL1483_1508 ENOG4105CV6 ABC transporter, permease WL1483_151 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) WL1483_1510 ENOG4106KVJ cytochrome C assembly protein WL1483_1512 ENOG4105C5X domain protein WL1483_1514 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) WL1483_1515 ENOG4107R7I amino acid WL1483_1516 ENOG4105CGA flagellar basal-body rod protein FlgG WL1483_1518 ENOG4108YZA Nitrogen regulatory protein pii WL1483_1519 ENOG4107RSS Hydrogenase accessory protein HypB WL1483_1522 ENOG4108IAB Phoh family WL1483_1523 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WL1483_1525 ENOG4107RDB Major Facilitator WL1483_1529 ENOG4105F38 ABC transporter, permease WL1483_1530 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) WL1483_1531 ENOG4105DKP glycosyl transferase, family 9 WL1483_1533 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WL1483_1536 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_1537 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) WL1483_1538 ENOG4107QYX exodeoxyribonuclease v alpha WL1483_1539 ENOG4105BZU Histidine kinase WL1483_1540 ENOG4105BZ1 (ABC) transporter WL1483_1541 ENOG4107QWE )-transporter WL1483_1542 ENOG4108W2Y isochorismatase WL1483_1543 ENOG4105E7A Glutamine amidotransferase WL1483_1546 ENOG4105EP9 oxidoreductase WL1483_1547 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WL1483_1548 ENOG4105CVM Molybdenum cofactor synthesis domain protein WL1483_1549 ENOG4105PAN UPF0352 protein WL1483_155 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WL1483_1550 ENOG4107QI1 Mate efflux family protein WL1483_1551 ENOG4105CAQ asparagine synthetase WL1483_1553 ENOG4108W15 Protein of unknown function (DUF1456) WL1483_1556 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) WL1483_1558 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) WL1483_1559 ENOG4108SX3 cytoplasmic protein WL1483_156 ENOG41060NJ transcriptional regulator WL1483_1560 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WL1483_1561 ENOG4105C0A alcohol dehydrogenase WL1483_1562 ENOG4105C45 hydrogenase expression formation protein (HypE) WL1483_1563 ENOG4108ZQS transposase WL1483_1566 ENOG4105D7Q type ii secretion system WL1483_1567 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WL1483_1568 ENOG4105CA3 membrane-bound lytic murein transglycosylase WL1483_1569 ENOG4105C7B Threonine dehydratase WL1483_157 ENOG4108UJU UPF0301 protein WL1483_1570 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) WL1483_1571 ENOG4105GR3 Histidine kinase WL1483_1574 ENOG4105DZR Type I site-specific deoxyribonuclease WL1483_1576 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WL1483_1577 ENOG4105E89 ABC transporter WL1483_1578 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WL1483_1579 ENOG4107S6Z Na H antiporter WL1483_1583 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) WL1483_1585 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WL1483_1586 ENOG4105D05 Receptor WL1483_1589 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_1591 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) WL1483_1593 ENOG4108R3E Dna-3-methyladenine glycosylase i WL1483_1594 ENOG4108IPJ Membrane WL1483_1595 ENOG4105C8J )-transporter WL1483_1597 ENOG4105C0Z ABC transporter WL1483_1599 ENOG4105DJ4 phosphatidylserine decarboxylase WL1483_160 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WL1483_1602 ENOG4105CIH Imidazole acetol-phosphate transaminase WL1483_1605 ENOG4107QXK peptidase WL1483_1606 ENOG4105D5Q Arginine ornithine antiporter WL1483_1607 ENOG4105C9X ppx gppa phosphatase WL1483_1608 ENOG4105EMN RNA polymerase sigma factor WL1483_1609 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) WL1483_1610 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase WL1483_1611 ENOG4107QWK SAICAR synthetase WL1483_1612 ENOG4108UKZ OsmC family WL1483_1613 ENOG4105E4F Isochorismate synthase WL1483_1614 ENOG4107R11 Transcriptional regulator WL1483_1616 ENOG4108J1Q WL1483_1617 ENOG4105EYM Major Facilitator superfamily WL1483_1619 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WL1483_1620 ENOG4105BZU Histidine kinase WL1483_1622 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY WL1483_1623 ENOG4105D4P Coproporphyrinogen iii oxidase WL1483_1630 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WL1483_1632 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) WL1483_1633 ENOG4105C22 threonyL-tRNA synthetase WL1483_1634 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WL1483_1635 ENOG4108J59 Extracellular solute-binding protein, family 5 WL1483_1636 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) WL1483_1638 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) WL1483_1640 ENOG4108MJ3 acetyltransferase WL1483_1642 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) WL1483_1644 ENOG4108JJ9 ABC, transporter WL1483_1645 ENOG4105BZU Histidine kinase WL1483_1647 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) WL1483_1648 ENOG4108J1Q WL1483_1649 ENOG4105CI1 PTS System WL1483_1651 ENOG4105CPB ATP-dependent endonuclease of the OLD family WL1483_1654 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WL1483_1658 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WL1483_166 ENOG4105EFX secretion protein, HlyD family WL1483_1660 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WL1483_1662 ENOG4105CHR reductase WL1483_1663 ENOG4105C6Z Gluconate WL1483_1665 ENOG4105W39 Membrane WL1483_1667 ENOG4108WFC UPF0438 protein yifE WL1483_1668 ENOG4105DWU Membrane WL1483_1670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WL1483_1671 ENOG4105BZU Histidine kinase WL1483_1674 ENOG4105E3I toluene tolerance WL1483_1676 ENOG4108MVM Transposase WL1483_1678 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WL1483_1679 ENOG4105C8J )-transporter WL1483_168 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WL1483_1680 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WL1483_1685 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) WL1483_1686 ENOG4105DE4 1-phosphofructokinase WL1483_1688 ENOG4105DFU Cell wall formation (By similarity) WL1483_1689 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) WL1483_169 ENOG4108J1Q WL1483_1691 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) WL1483_1692 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit WL1483_1695 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WL1483_1696 ENOG4105D98 threonine synthase WL1483_1698 ENOG4108J1Q WL1483_17 ENOG4105C7I Dehydrogenase WL1483_1700 ENOG4105C31 Tryptophanyl-tRNA synthetase WL1483_1702 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WL1483_1703 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate WL1483_1705 ENOG4107R73 Mate efflux family protein WL1483_1706 ENOG41090A1 ferritin WL1483_1707 ENOG4105C9M aspartyl-trna synthetase WL1483_1708 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WL1483_1709 ENOG4105C1J atp-dependent rna helicase WL1483_171 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WL1483_1716 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) WL1483_1718 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WL1483_172 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) WL1483_1720 ENOG4105DFF Rod shape-determining protein mreb WL1483_1721 ENOG4108JQ7 (ABC) transporter WL1483_1723 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) WL1483_1724 ENOG4105CSM endonuclease III WL1483_1725 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) WL1483_1728 ENOG4105N7H Cytochrome WL1483_1729 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) WL1483_173 ENOG4105EAH synthase WL1483_1731 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_1733 ENOG4106R3P AraC family transcriptional regulator WL1483_1734 ENOG4108M8S permease YjgP YjgQ family protein WL1483_1738 ENOG4105Z6B inner membrane protein yjfl WL1483_1739 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WL1483_174 ENOG4105C26 Dehydrogenase WL1483_1740 ENOG4105C5H ABC transporter WL1483_1742 ENOG4105CXN decarboxylase WL1483_1743 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) WL1483_1746 ENOG4105CEM UPF0597 protein WL1483_1748 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_1749 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WL1483_1750 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WL1483_1752 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) WL1483_1754 ENOG4108ZQS transposase WL1483_1755 ENOG4105UFD tol-pal system protein YbgF WL1483_1758 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) WL1483_176 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_1760 ENOG4105E5Q amino acid AbC transporter WL1483_1761 ENOG4105KDC 50s ribosomal protein l28 WL1483_1762 ENOG4105D7W serine acetyltransferase WL1483_1763 ENOG4105TMB Formate nitrite transporter WL1483_1765 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WL1483_1768 ENOG4108J1Q WL1483_1769 ENOG4105EW9 transcriptional regulator AsnC family WL1483_1770 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) WL1483_1772 ENOG4105DY2 Paraquat-inducible protein b WL1483_1773 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i WL1483_1774 ENOG4105M08 Membrane WL1483_1775 ENOG4108RRZ Transcription elongation factor GreB WL1483_1776 ENOG4108J1Q WL1483_1777 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WL1483_1778 ENOG4105DUX Transporter WL1483_1779 ENOG4105C84 Histidine ammonia-lyase WL1483_178 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) WL1483_1781 ENOG4105D2T synthase WL1483_1782 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) WL1483_1783 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WL1483_1785 ENOG4105EJQ L-serine dehydratase WL1483_1786 ENOG4105CKD glutathione-regulated potassium-efflux system protein WL1483_1789 ENOG4105BZU Histidine kinase WL1483_179 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WL1483_1791 ENOG4105D6S protein involved in catabolism of external DNA WL1483_1793 ENOG4108RPX mosc domain containing protein WL1483_1794 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) WL1483_1795 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein WL1483_1796 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WL1483_1798 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WL1483_18 ENOG41076CZ activating enzyme WL1483_1802 ENOG4105E4C Lytic transglycosylase catalytic WL1483_1804 ENOG4108MVM Transposase WL1483_1805 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation WL1483_1808 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WL1483_181 ENOG4108MN8 Membrane WL1483_1810 ENOG4108KPB Flagellar basal-body rod protein FlgF WL1483_1812 ENOG4108J1Q WL1483_1814 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WL1483_1815 ENOG4105C7N Xanthine uracil vitamin C permease WL1483_1817 ENOG4108ZQS transposase WL1483_1818 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WL1483_1825 ENOG4105BZ1 (ABC) transporter WL1483_1826 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) WL1483_1827 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WL1483_183 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_1831 ENOG4105D56 permease protein WL1483_1832 ENOG4108MVM Transposase WL1483_1833 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WL1483_1836 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) WL1483_1839 ENOG4105DPN Oligoendopeptidase f WL1483_1840 ENOG4105CUB amino acid WL1483_1842 ENOG4108XG4 DNA-binding transcriptional regulator WL1483_1843 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WL1483_1844 ENOG4105DU6 RNA polymerase WL1483_1845 ENOG4105XPQ lipid carrier protein WL1483_1846 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) WL1483_1847 ENOG4105EMN RNA polymerase sigma factor WL1483_1848 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WL1483_1849 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein WL1483_1851 ENOG4105XEP YhcH YjgK YiaL family protein WL1483_1854 ENOG4105D6A Electron transport complex WL1483_1855 ENOG4105CFI type iii restriction protein res subunit WL1483_1856 ENOG4105FCD Major Facilitator WL1483_1858 ENOG4105N14 lysine exporter protein LysE YggA WL1483_1860 ENOG4105G0K glycine radical enzyme YjjI family WL1483_1861 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia WL1483_1862 ENOG4105DHQ Histidine kinase WL1483_1864 ENOG4105CQ2 DNA polymerase WL1483_1865 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) WL1483_1866 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WL1483_1869 ENOG4105X3C heme exporter protein WL1483_1871 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WL1483_1872 ENOG4105C2X Arabinose 5-phosphate isomerase WL1483_1874 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) WL1483_1875 ENOG4109015 Biopolymer transport protein exbD tolR WL1483_1878 ENOG41061A0 Mu-like prophage Flumu protein WL1483_1879 ENOG4105VRT cytoplasmic protein WL1483_1882 ENOG4105E0F Histidine kinase WL1483_1884 ENOG4105E14 MotA TolQ exbB proton channel WL1483_1885 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) WL1483_1886 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) WL1483_1888 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WL1483_1889 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) WL1483_189 ENOG4107QZF nitrite reductase NADPH large subunit WL1483_1890 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) WL1483_1894 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WL1483_1897 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin WL1483_1899 ENOG4105G6Z alkaline phosphatase WL1483_190 ENOG4105CN1 protease WL1483_1903 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WL1483_1905 ENOG4105EZE Cupin 4 family protein WL1483_1910 ENOG4107R11 Transcriptional regulator WL1483_1911 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A WL1483_1912 ENOG4105C7S Dehydrogenase WL1483_1914 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) WL1483_1915 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA WL1483_1918 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) WL1483_192 ENOG4107EXC regulatoR WL1483_1920 ENOG41061WM D-Alanyl-D-Alanine WL1483_1922 ENOG4105EMU Dehydrogenase WL1483_1923 ENOG4108U1V ABC transporter, permease WL1483_1924 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WL1483_1926 ENOG4106YXT transposase WL1483_1930 ENOG4108RG0 uracil-dna glycosylase WL1483_1932 ENOG4105CVM Molybdenum cofactor synthesis domain protein WL1483_1937 ENOG4105VFU Rna-binding protein WL1483_1938 ENOG41063Z6 transcriptional regulator, lysR family WL1483_1939 ENOG4105M00 molybdopterin converting factor, subunit 1 WL1483_194 ENOG4105CHW UPF0052 protein WL1483_1940 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) WL1483_1941 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ WL1483_1943 ENOG4105C7N Xanthine uracil vitamin C permease WL1483_1944 ENOG4105DJY efflux transporter, rnd family, mfp subunit WL1483_195 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) WL1483_1952 ENOG4107RYR Transcriptional regulator, Crp Fnr family WL1483_1954 ENOG4106P2F Pfam:Pili_assembly_C WL1483_1955 ENOG4105C28 cystathionine WL1483_1957 ENOG4107GZ4 SanA protein WL1483_1958 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WL1483_196 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) WL1483_1961 ENOG4107QN1 sodium solute WL1483_1962 ENOG4105D60 lipoprotein releasing system transmembrane protein WL1483_1965 ENOG4107QPN acyl-Coa dehydrogenase WL1483_1966 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WL1483_1968 ENOG4105E0F Histidine kinase WL1483_1969 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) WL1483_197 ENOG4106MWK domain protein WL1483_1970 ENOG4105D7Z glutathione synthase WL1483_1971 ENOG4105DWY Agmatine deiminase WL1483_1972 ENOG4107QJR hflk protein WL1483_1974 ENOG4105BZU Histidine kinase WL1483_1976 ENOG4105C7K acetolactate synthase WL1483_1979 ENOG4108IYU L-aspartate oxidase WL1483_198 ENOG4105BZU Histidine kinase WL1483_1981 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WL1483_1982 ENOG4105DB7 PHP domain protein WL1483_1983 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) WL1483_1984 ENOG4105C0H protease WL1483_1985 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WL1483_1987 ENOG4105DCF alanine dehydrogenase WL1483_1988 ENOG4105C6Y Udp-glucose 6-dehydrogenase WL1483_1989 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WL1483_199 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WL1483_1991 ENOG4105C1J atp-dependent rna helicase WL1483_1993 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) WL1483_1995 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) WL1483_20 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WL1483_200 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase WL1483_2000 ENOG4105W87 Cbs domain WL1483_2003 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) WL1483_2006 ENOG4108JA2 transcriptioN-repair coupling factor WL1483_2009 ENOG4108J1Q WL1483_201 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WL1483_2010 ENOG4105UQX Mate efflux family protein WL1483_2011 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA WL1483_2012 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WL1483_2013 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) WL1483_2015 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) WL1483_2016 ENOG4105DSJ YicC domain protein WL1483_2018 ENOG4105CJR Integral membrane protein (MviN WL1483_202 ENOG4105HHA aminodeoxychorismate lyase WL1483_2022 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_2024 ENOG4107FW0 short-chain dehydrogenase reductase WL1483_2025 ENOG4108MVM Transposase WL1483_2026 ENOG4105E68 Sulfatase WL1483_2028 ENOG4105I4A GCN5-related N-acetyltransferase WL1483_2029 ENOG4105K9Q Binds to the 23S rRNA (By similarity) WL1483_203 ENOG4105VTB flagellar biosynthesis protein fliO WL1483_2030 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) WL1483_2032 ENOG4107ZYR domain protein WL1483_2034 ENOG4105C29 acyl-CoA thioesterase WL1483_2035 ENOG4105CI2 imidazolone-5-propionate hydrolase WL1483_2036 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) WL1483_2038 ENOG4105D06 uba thif-type nad fad binding protein WL1483_204 ENOG4105WH1 Two component transcriptional regulator luxr family WL1483_2040 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) WL1483_2041 ENOG4108XDN Transcriptional regulator WL1483_2044 ENOG4107QX8 SPFH domain, Band 7 family protein WL1483_2046 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_2047 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WL1483_2048 ENOG4105C5B carbamate kinase WL1483_2049 ENOG4108MVM Transposase WL1483_2050 ENOG4105CUB amino acid WL1483_2051 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WL1483_2052 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WL1483_2053 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WL1483_2055 ENOG4108W2P Methyl-accepting chemotaxis WL1483_2056 ENOG4105CXZ ABC transporter, permease WL1483_2058 ENOG4105DDY UPF0142 protein ycaO WL1483_2060 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) WL1483_2061 ENOG4108MVM Transposase WL1483_2062 ENOG4105EEQ Na H antiporter WL1483_2065 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WL1483_2066 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WL1483_207 ENOG4105D9M gamma-glutamylcysteine synthetase WL1483_2071 ENOG4105BZ1 (ABC) transporter WL1483_2072 ENOG4108MVM Transposase WL1483_2073 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WL1483_2074 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WL1483_2076 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) WL1483_208 ENOG4108VBZ doxx family WL1483_2082 ENOG4105K89 arsenate reductase WL1483_2083 ENOG4105C01 Dihydroxy-acid dehydratase WL1483_2089 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WL1483_2092 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap WL1483_2093 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WL1483_2095 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) WL1483_2096 ENOG4105E09 nadh pyrophosphatase WL1483_2099 ENOG4105CSV Glutaminase WL1483_21 ENOG4105CM6 amino acid regulated cytosolic protein WL1483_2101 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WL1483_2103 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs WL1483_2105 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WL1483_2106 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WL1483_2107 ENOG4105XJC Two component transcriptional regulator (Winged helix family WL1483_2108 ENOG4108T8E UPF0325 protein WL1483_2109 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WL1483_211 ENOG4108ZQS transposase WL1483_2110 ENOG4107R88 Chemotaxis protein (CheV) WL1483_2111 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 WL1483_2114 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase WL1483_2116 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 WL1483_2117 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WL1483_2118 ENOG4105C3F Signal peptidase i WL1483_2119 ENOG4105C8S subunit m WL1483_212 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_2121 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WL1483_2123 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WL1483_2127 ENOG4105XCT Protein of unknown function (DUF2489) WL1483_2128 ENOG4108J1Q WL1483_213 ENOG4105CVG Homoserine O-transsuccinylase WL1483_2130 ENOG4108JQ6 ABC transporter WL1483_2132 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) WL1483_2133 ENOG4105E0A ABC, transporter WL1483_2134 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WL1483_2138 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) WL1483_214 ENOG4105D3A purine nucleoside phosphorylase DeoD-type WL1483_2140 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) WL1483_2141 ENOG4105C5Q Transcriptional regulator WL1483_2142 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WL1483_2143 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WL1483_2144 ENOG4105DR4 Methyltransferase WL1483_2145 ENOG4105PM1 preprotein translocase subunit SecE WL1483_2146 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WL1483_2147 ENOG4105JQN Transcriptional regulator WL1483_2149 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation WL1483_215 ENOG4105DZP Membrane-associated zinc metalloprotease WL1483_2151 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) WL1483_2153 ENOG4105C4K Nad synthetase WL1483_2154 ENOG4106SMU thiamine transporter membrane protein WL1483_2155 ENOG4105CSR polyphosphate kinase 2 WL1483_2157 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WL1483_216 ENOG41076E6 Uroporphyrinogen-III Synthase WL1483_2161 ENOG4105CQS hydrogenase expression formation protein HypD WL1483_2162 ENOG4105PDP Short chain dehydrogenase WL1483_2163 ENOG410600T transposase WL1483_2164 ENOG4108MDY Fimbrial WL1483_2165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WL1483_2166 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WL1483_2167 ENOG4107R28 alpha amylase, catalytic region WL1483_2168 ENOG4108UUM single-stranded DNA-binding protein WL1483_217 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) WL1483_2172 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) WL1483_2173 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) WL1483_2174 ENOG4107T0D ABC, transporter WL1483_2176 ENOG4108J1Q WL1483_2178 ENOG41090HJ UPF0265 protein WL1483_2179 ENOG4108YZY peptidylprolyl cis-trans isomerase WL1483_218 ENOG4108ZP8 Acetolactate synthase small subunit WL1483_2182 ENOG4108MVM Transposase WL1483_2183 ENOG4105DM4 PTS System WL1483_2184 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) WL1483_2186 ENOG4105XQ6 frataxin-like protein WL1483_2187 ENOG4106V6P Exoenzyme S synthesis protein C WL1483_2188 ENOG4108VAU general secretion pathway protein G WL1483_219 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain WL1483_2190 ENOG4105E5M Multidrug resistance protein D WL1483_2193 ENOG4105WD1 Membrane WL1483_2195 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase WL1483_22 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) WL1483_2202 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase WL1483_2203 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) WL1483_2204 ENOG4107QSN dihydrolipoamide acetyltransferase WL1483_2205 ENOG4108V3E phosphoribosylglycinamide formyltransferase WL1483_2206 ENOG41072GX Peptidase M22 Glycoprotease WL1483_2207 ENOG4105WH1 Two component transcriptional regulator luxr family WL1483_2211 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WL1483_2214 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WL1483_2216 ENOG4105EXG Transcriptional regulator WL1483_2217 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) WL1483_2219 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) WL1483_2220 ENOG4105CKU formyltetrahydrofolate synthetase WL1483_2221 ENOG4105DBI uridine monophosphokinase WL1483_2224 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) WL1483_2225 ENOG4105CFP Peptidase U32 WL1483_2226 ENOG4105EYW Ion transport protein WL1483_223 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) WL1483_2230 ENOG4108RXX maleylacetoacetate isomerase WL1483_2233 ENOG4107QJT sodium dicarboxylate symporter WL1483_2234 ENOG4105CS6 Rhs element vgr protein WL1483_2235 ENOG4105IPS esterase WL1483_2236 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WL1483_2239 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) WL1483_2240 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) WL1483_2241 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WL1483_2244 ENOG4105C2D reductase WL1483_2245 ENOG4105VQ0 flagellar hook-basal body complex protein fliE WL1483_2247 ENOG4107MBR 17 kDa surface antigen WL1483_2248 ENOG4105W49 UPF0434 protein WL1483_2250 ENOG4107QX9 Thiol disulfide interChange protein WL1483_2251 ENOG4105CXB phosphoribosylaminoimidazole synthetase WL1483_2253 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WL1483_2258 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) WL1483_226 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity WL1483_2260 ENOG4105DC8 reductase WL1483_2261 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP WL1483_2267 ENOG4105CEM UPF0597 protein WL1483_2268 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WL1483_2271 ENOG4105BZU Histidine kinase WL1483_2272 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WL1483_2274 ENOG4105RPH Inner membrane protein YddG WL1483_2275 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B WL1483_2277 ENOG4105CAF HipA N-terminal domain protein WL1483_2278 ENOG4105CFQ glutamine synthetase WL1483_228 ENOG4105CUB amino acid WL1483_2280 ENOG4105CEY Amp-dependent synthetase and ligase WL1483_2283 ENOG4105EJC lysr family transcriptional regulator WL1483_2284 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj WL1483_2287 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_2288 ENOG4105BZG amino acid carrier protein WL1483_229 ENOG4108WI1 Dna topoisomerase WL1483_2290 ENOG4105BZU Histidine kinase WL1483_2292 ENOG4105XWI UPF0304 protein WL1483_2293 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WL1483_2294 ENOG4105DKQ ROK family WL1483_2297 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WL1483_2299 ENOG4105BZU Histidine kinase WL1483_23 ENOG4108UW5 maltose o-acetyltransferase WL1483_230 ENOG4106AKX UPF0229 protein WL1483_2300 ENOG4105CM2 brancheD-chain amino acid aminotransferase WL1483_2301 ENOG4105CGA flagellar basal-body rod protein FlgG WL1483_2305 ENOG4105VFK BolA family WL1483_2308 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WL1483_2309 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) WL1483_2312 ENOG4108R1E Serine threonine protein phosphatase 1 WL1483_2314 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) WL1483_2317 ENOG4105C1J atp-dependent rna helicase WL1483_2318 ENOG41090EX DsrE family WL1483_2319 ENOG4105C5Y PTS System WL1483_232 ENOG4105BZU Histidine kinase WL1483_2320 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_2321 ENOG4105E5Z arginine transporter ATP-binding subunit WL1483_2322 ENOG4105DY2 Paraquat-inducible protein b WL1483_2325 ENOG4108VAU general secretion pathway protein G WL1483_2328 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WL1483_2330 ENOG4105Q26 Siderophore-interacting protein WL1483_2333 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) WL1483_2337 ENOG4108I5W peptide transport system, permease protein WL1483_2338 ENOG4105M6F mutator MutT protein WL1483_2343 ENOG4105BZ1 (ABC) transporter WL1483_2345 ENOG41082IR Excinuclease ABC C subunit domain protein WL1483_2347 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WL1483_2348 ENOG4105CE9 30S ribosomal protein S2 WL1483_2349 ENOG4105D1F ATP-binding protein WL1483_2353 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) WL1483_2355 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WL1483_2356 ENOG4105HEE Binding Domain protein WL1483_2358 ENOG4105C11 sulfate adenylyltransferase), subunit 2 WL1483_2361 ENOG4105C2W permease WL1483_2362 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) WL1483_2363 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WL1483_2366 ENOG4105CJN penicillin-binding protein WL1483_2370 ENOG4105E0M Sulfatase WL1483_2375 ENOG4105K89 arsenate reductase WL1483_2376 ENOG4105HDK L-asparaginase WL1483_2378 ENOG4108J1Q WL1483_2380 ENOG4107YIM Involved in the transcription termination process (By similarity) WL1483_2383 ENOG4108J1Q WL1483_2384 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WL1483_2385 ENOG41076UM multiple antibiotic resistance (MarC)-related protein WL1483_2388 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WL1483_2389 ENOG4105VNT transposase (IS4 family) protein WL1483_2390 ENOG4108J1Q WL1483_2392 ENOG4105CRK lysyL-tRNA synthetase WL1483_2397 ENOG4105DC1 bifunctional purine biosynthesis protein purh WL1483_24 ENOG4108WGS hydrogenase 2-specific chaperone WL1483_240 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WL1483_2401 ENOG4105CKI cobalamin synthesis protein WL1483_2404 ENOG4105D1U peptidase U62 modulator of DNA gyrase WL1483_2405 ENOG4105VJY transcriptional regulator WL1483_2406 ENOG4108J1Q WL1483_2408 ENOG4108VGW abc transporter atp-binding protein WL1483_2409 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) WL1483_2410 ENOG4107YD3 Thioesterase WL1483_2411 ENOG4105DFE Dna adenine methylase WL1483_2414 ENOG4105C2W permease WL1483_2417 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) WL1483_2418 ENOG4105D3G Pseudouridine synthase WL1483_2419 ENOG4105D1A Methyltransferase WL1483_242 ENOG4107RUY (E1 component), alpha subunit WL1483_2422 ENOG4105E0F Histidine kinase WL1483_2423 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WL1483_2426 ENOG4107QN2 dihydrolipoyl dehydrogenase WL1483_2427 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WL1483_2429 ENOG4105BZU Histidine kinase WL1483_2430 ENOG4105D64 Mechanosensitive ion channel WL1483_2431 ENOG4105EIF outer membrane protein W WL1483_2432 ENOG4105C3U ABC transporter WL1483_2433 ENOG4107RGM aldo keto reductase WL1483_2434 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) WL1483_2435 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WL1483_2436 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WL1483_2437 ENOG4105DWY Agmatine deiminase WL1483_244 ENOG4105F8V Hydrolase, tatD family WL1483_2440 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WL1483_2442 ENOG4105CHC glucokinase (EC 2.7.1.2) WL1483_2444 ENOG4107RH8 nuclease SbcCD subunit D WL1483_2445 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) WL1483_2446 ENOG4108UJD 30S ribosomal protein S9 WL1483_2449 ENOG4107R88 Chemotaxis protein (CheV) WL1483_245 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) WL1483_2450 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WL1483_2455 ENOG4105E3S small subunit WL1483_2458 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) WL1483_246 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) WL1483_2461 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WL1483_2462 ENOG4105CTD carboxy-peptidase WL1483_2463 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) WL1483_2466 ENOG4105ETE Transcriptional regulator (LacI family WL1483_2468 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) WL1483_2471 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WL1483_2472 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) WL1483_2474 ENOG410667J hydrolase WL1483_2475 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) WL1483_2476 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WL1483_2477 ENOG4108EM1 reductase WL1483_2478 ENOG4105D58 Diguanylate phosphodiesterase WL1483_2479 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) WL1483_248 ENOG4105C7K acetolactate synthase WL1483_2482 ENOG4105EFX secretion protein, HlyD family WL1483_2485 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) WL1483_2486 ENOG4105M7P phage repressor WL1483_2489 ENOG410600T transposase WL1483_249 ENOG4105C34 Pseudouridine synthase WL1483_2493 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WL1483_2495 ENOG4105C9X ppx gppa phosphatase WL1483_2497 ENOG4105CUG Oligopeptidase b WL1483_2498 ENOG4105EN6 Membrane WL1483_2499 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) WL1483_250 ENOG4108JCI Transcriptional regulator WL1483_2501 ENOG4105BZJ Electron transfer flavoprotein WL1483_2502 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WL1483_2505 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WL1483_2508 ENOG4105C5I Dehydrogenase WL1483_2510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WL1483_2511 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WL1483_2512 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) WL1483_2513 ENOG4108JU5 Magnesium and cobalt efflux protein WL1483_2514 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) WL1483_2517 ENOG4105DMR ABC, transporter WL1483_252 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase WL1483_2521 ENOG4105BZN citrate synthase WL1483_2528 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) WL1483_253 ENOG4105CG3 alpha amylase, catalytic region WL1483_2533 ENOG4105K2J Transcriptional regulator WL1483_2534 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WL1483_2535 ENOG4105CVM Molybdenum cofactor synthesis domain protein WL1483_2536 ENOG4106HNH Acyl-transferase WL1483_2537 ENOG4105EZR dyp-type peroxidase family protein WL1483_2539 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WL1483_2540 ENOG4108I62 cina-like protein WL1483_2542 ENOG4105CHU acetyl-coa acetyltransferase WL1483_2543 ENOG4105FA0 parb-like partition protein WL1483_2546 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) WL1483_2551 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) WL1483_2555 ENOG4108535 NAD dependent epimerase/dehydratase family WL1483_2557 ENOG4105CPQ Dehydrogenase WL1483_2558 ENOG4105DM4 PTS System WL1483_2561 ENOG4105E0U tyrosine-specific transport protein WL1483_2562 ENOG4105C9U ATP-dependent DNA helicase RecQ WL1483_2563 ENOG410630P Transcriptional regulator WL1483_2565 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) WL1483_2567 ENOG4105CGD Nad-dependent epimerase dehydratase WL1483_2569 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type WL1483_257 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WL1483_2575 ENOG4105Z2P Protein of unknown function (DUF465) WL1483_2579 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family WL1483_2580 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA WL1483_2583 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WL1483_2585 ENOG4105E3W Two component transcriptional regulator (Winged helix family WL1483_2586 ENOG4107VXZ Hydrolase WL1483_2587 ENOG4105C6T cysteine synthase WL1483_2588 ENOG4105BZE flagellar hook protein, FlgE WL1483_2589 ENOG4105N5T Radical SAM Protein WL1483_2591 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WL1483_2593 ENOG4108IUZ ABC transporter WL1483_2597 ENOG4107QJE Chromosome Partitioning Protein WL1483_260 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) WL1483_2603 ENOG4105C37 (CBS) domain WL1483_2604 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) WL1483_2605 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WL1483_2606 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) WL1483_2607 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein WL1483_2608 ENOG4105E2Z phosphate ABC transporter (Permease WL1483_2611 ENOG4105E43 Extracellular solute-binding protein, family 5 WL1483_2613 ENOG4105NBK UPF0345 protein WL1483_2614 ENOG4105CAK Cell division ATP-binding protein ftsE WL1483_2617 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WL1483_2619 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) WL1483_2620 ENOG4108TN6 type iii secretion WL1483_2625 ENOG41076HS cation diffusion facilitator family transporter WL1483_2627 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) WL1483_2628 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WL1483_2629 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WL1483_2633 ENOG4108Z86 Glutamine amidotransferase WL1483_2634 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) WL1483_2635 ENOG4107RD7 Flagellar Motor Protein, MotA WL1483_2636 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase WL1483_2637 ENOG4105FAT Acyl-transferase WL1483_2638 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) WL1483_264 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) WL1483_2643 ENOG4108IPT Naphthoate synthase WL1483_2645 ENOG4107EF8 Glycosyl transferase (Group 1 WL1483_2647 ENOG4105KCK Peptidoglycan-associated lipoprotein WL1483_2649 ENOG4105VPD cellular component movement WL1483_2651 ENOG4106H3A restriction WL1483_2652 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) WL1483_2653 ENOG4105C01 Dihydroxy-acid dehydratase WL1483_2655 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WL1483_2656 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) WL1483_2657 ENOG4105CBT Fructose-1,6-bisphosphatase WL1483_2658 ENOG4105KWW Biogenesis protein WL1483_2659 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WL1483_2661 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain WL1483_2663 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WL1483_2664 ENOG4105BZU Histidine kinase WL1483_2666 ENOG4105Q4A inner membrane protein yciS WL1483_267 ENOG4105DFG type I secretion outer membrane protein WL1483_2670 ENOG41088SP formiminoglutamate hydrolase WL1483_2673 ENOG4105C7W Xanthine dehydrogenase WL1483_2674 ENOG4105EHG Permease protein WL1483_2680 ENOG4105EUZ Beta-lactamase domain protein WL1483_2681 ENOG4105DEN Luciferase family WL1483_2682 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WL1483_2683 ENOG4105BZU Histidine kinase WL1483_2685 ENOG4105CAS nag kinase WL1483_2686 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) WL1483_2688 ENOG4105CUY Mechanosensitive ion channel WL1483_2689 ENOG41090ED Protein with unknown function (DUF469) WL1483_2691 ENOG4108ZIT Ferredoxin, 2FE-2S WL1483_2692 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) WL1483_2694 ENOG4105DR5 peptidase WL1483_2696 ENOG4105BZU Histidine kinase WL1483_2698 ENOG4108EC8 DNA internalization-related competence protein ComEC WL1483_270 ENOG4105CDU Replicative dna helicase WL1483_2701 ENOG4105C5Q Transcriptional regulator WL1483_2702 ENOG4105CAT Cytidine monophosphate kinase WL1483_2703 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WL1483_2704 ENOG4108Z33 Thiol disulfide Interchange Protein WL1483_2706 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WL1483_2707 ENOG4108IJ0 Aspartate ammonia-lyase WL1483_2713 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WL1483_2715 ENOG410903C (LipO)protein WL1483_2716 ENOG4108UDW Transcriptional regulator, luxr family WL1483_2717 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WL1483_2718 ENOG4105C1A potassium transporter peripheral membrane WL1483_2719 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WL1483_2721 ENOG4105C2W permease WL1483_2722 ENOG4105DUU IucA IucC family protein WL1483_2724 ENOG4105C8P )-transporter WL1483_2725 ENOG4107R88 Chemotaxis protein (CheV) WL1483_2726 ENOG4108HU6 Metal dependent phosphohydrolase WL1483_2727 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein WL1483_2728 ENOG410600T transposase WL1483_2731 ENOG4105EQ2 LysR family Transcriptional regulator WL1483_2734 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WL1483_2735 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) WL1483_2737 ENOG4105BZ4 penicillin-binding protein WL1483_2738 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) WL1483_274 ENOG4105YAZ 4-amino-4-deoxychorismate lyase WL1483_2740 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) WL1483_2741 ENOG4108VKG metal-dependent hydrolase WL1483_2746 ENOG41066YJ Beta-lactamase WL1483_2749 ENOG4105CTS PTS system mannitol-specific WL1483_2751 ENOG4105CJB Exodeoxyribonuclease I WL1483_2754 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) WL1483_2755 ENOG4105QDK Flavodoxin WL1483_2757 ENOG4107S90 membrAne WL1483_2759 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WL1483_276 ENOG4108UMI ABC transporter, permease WL1483_2761 ENOG4105C0R drug resistance transporter emrb qaca subfamily WL1483_2763 ENOG4105CBC glutamate synthase WL1483_2765 ENOG4105DQR SNARE associated Golgi WL1483_2767 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WL1483_2769 ENOG4105CHR reductase WL1483_277 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WL1483_2770 ENOG4106Z1T Nicotinamide Mononucleotide Transporter WL1483_2771 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WL1483_2774 ENOG4107P2S Transcriptional regulator WL1483_2776 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WL1483_2778 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) WL1483_2779 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WL1483_278 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WL1483_2781 ENOG4105CXY transporter WL1483_2782 ENOG4107RH7 Nicotinate phosphoribosyltransferase WL1483_2784 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WL1483_2785 ENOG4108IV0 ABC, transporter WL1483_2789 ENOG4105DPX Hydrogenase, large subunit WL1483_2790 ENOG4108RE9 Phosphodiesterase WL1483_2791 ENOG4107QUY Guanine deaminase WL1483_2792 ENOG4105DWD nucleoside recognition domain protein WL1483_2793 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap WL1483_2795 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WL1483_2796 ENOG4105E5W Transporter WL1483_2798 ENOG4105R2J Conserved Protein WL1483_28 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component WL1483_280 ENOG4105DNZ Alpha Beta Hydrolase WL1483_2800 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) WL1483_2801 ENOG4105D1S lipid A biosynthesis WL1483_2802 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WL1483_2803 ENOG4105D65 subunit l WL1483_2804 ENOG4105EIN peptidylprolyl cis-trans isomerase WL1483_2805 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) WL1483_2806 ENOG4106H78 methyltransferase WL1483_2807 ENOG4105C87 Aminotransferase class I and II WL1483_281 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WL1483_2811 ENOG4105F1S paraquat-inducible protein a WL1483_2812 ENOG4105CD3 dihydroorotase WL1483_2813 ENOG4108EU3 peptide transport system, permease WL1483_2815 ENOG4108JJ8 (ABC) transporter WL1483_2816 ENOG4107QZ7 Cellulose synthase catalytic subunit WL1483_2817 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) WL1483_2818 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) WL1483_2819 ENOG4105CQ7 ATP-dependent helicase WL1483_282 ENOG4105C26 Dehydrogenase WL1483_2820 ENOG4105CU9 asparagine synthetase A WL1483_2821 ENOG4108ZQS transposase WL1483_2824 ENOG4105X2V dna damage-inducible protein WL1483_2825 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_2828 ENOG4105DVT helicase WL1483_2830 ENOG4105EAQ (twin-arginine translocation) pathway signal WL1483_2832 ENOG4105VGS 50s ribosomal protein l32 WL1483_2833 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) WL1483_2834 ENOG4108KXH Ybak prolyl-tRNA synthetase associated WL1483_2838 ENOG4105DHP deoxycytidine triphosphate deaminase WL1483_284 ENOG4105DP9 ABC transporter WL1483_2841 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WL1483_2842 ENOG4105D6U Sodium Glutamate Symporter WL1483_2843 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) WL1483_2845 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) WL1483_2846 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_2848 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) WL1483_285 ENOG4105W5Q DNA repair protein (RadC WL1483_2850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WL1483_2851 ENOG4105EMK carboxylate amino acid amine transporter WL1483_2853 ENOG4105QAX Iron-sulfur WL1483_286 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WL1483_2862 ENOG4108I0Q anthranilate phosphoribosyltransferase WL1483_2864 ENOG4108WTW DNA transposition protein WL1483_2865 ENOG4108YZN class I peptide chain release factor WL1483_2868 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) WL1483_287 ENOG4105C6K Malic enzyme WL1483_2870 ENOG410600T transposase WL1483_2872 ENOG4108J1Q WL1483_2880 ENOG4105E4C Lytic transglycosylase catalytic WL1483_2881 ENOG4105CPF Cell wall formation (By similarity) WL1483_2883 ENOG4105D41 biosynthesis protein thiH WL1483_2885 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WL1483_2886 ENOG41064T2 transcriptional regulator, lysR family WL1483_2889 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) WL1483_289 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins WL1483_2890 ENOG4105I08 Pseudouridine synthase WL1483_2891 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold WL1483_2893 ENOG4108IQK o-acetylhomoserine WL1483_2897 ENOG4106KNT transcriptional regulator WL1483_2898 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) WL1483_29 ENOG4105DVT helicase WL1483_290 ENOG4105TVJ transport system, permease WL1483_2900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WL1483_2902 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WL1483_2905 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant WL1483_2907 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WL1483_2909 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WL1483_2910 ENOG4105CN7 Flagellar biosynthetic protein FliP WL1483_2911 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) WL1483_2912 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) WL1483_2914 ENOG4105RKX Protein of unknown function (DUF2498) WL1483_2916 ENOG4105EWT decarboxylase family WL1483_2918 ENOG4108ZQS transposase WL1483_2919 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) WL1483_292 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) WL1483_2920 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) WL1483_2922 ENOG4105EW9 transcriptional regulator AsnC family WL1483_2925 ENOG4106PMH Extracellular solute-binding protein family 3 WL1483_2927 ENOG4105CPW cytochrome b561 WL1483_2929 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) WL1483_293 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF WL1483_2931 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WL1483_2938 ENOG4105C9A Phoh family WL1483_2939 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WL1483_2940 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WL1483_2941 ENOG4105C1J atp-dependent rna helicase WL1483_2942 ENOG4108VWS Yaeq family WL1483_2945 ENOG4106PG1 outer membrane usher protein WL1483_2946 ENOG4105NNS Autoinducer synthesis protein WL1483_2947 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) WL1483_2949 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving WL1483_295 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) WL1483_2950 ENOG4107QSN dihydrolipoamide acetyltransferase WL1483_2953 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase WL1483_2956 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) WL1483_2958 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) WL1483_296 ENOG4108MRH transcriptional regulatory protein WL1483_2960 ENOG4105FE9 pseudouridine synthase WL1483_2961 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WL1483_2964 ENOG4105CGK Exodeoxyribonuclease III WL1483_2968 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WL1483_2970 ENOG4105BZU Histidine kinase WL1483_2974 ENOG4105CSX c4-dicarboxylate anaerobic carrier WL1483_2976 ENOG4105EUJ GTP cyclohydrolase i WL1483_2978 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) WL1483_2979 ENOG4105DHI Methyltransferase WL1483_298 ENOG4105F1A Pyruvate formate-lyase WL1483_2984 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) WL1483_2987 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) WL1483_2988 ENOG4105ESV Glycosyl transferase, family 4 WL1483_2990 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) WL1483_2991 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) WL1483_2995 ENOG4105DG7 nitrate ABC transporter WL1483_2997 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WL1483_2998 ENOG4108J1Q WL1483_2999 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WL1483_3 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WL1483_30 ENOG4105CBX hi0933 family WL1483_3000 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase WL1483_3001 ENOG4105C1J atp-dependent rna helicase WL1483_3003 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_3005 ENOG4107S4Y M20 DapE family protein YgeY WL1483_3006 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit WL1483_3008 ENOG4108YRF PTS System WL1483_3009 ENOG4105C26 Dehydrogenase WL1483_3011 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WL1483_3012 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) WL1483_3016 ENOG4107QQ0 gntp family WL1483_3017 ENOG4105DUM transcriptional regulator, lysR family WL1483_3020 ENOG4108V1T peptidylprolyl cis-trans isomerase WL1483_3021 ENOG4108JQ7 (ABC) transporter WL1483_3022 ENOG4108MVM Transposase WL1483_3027 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WL1483_3028 ENOG4105BZU Histidine kinase WL1483_3029 ENOG4107RK2 ADP-ribose diphosphatase NudE WL1483_3033 ENOG4107QSI ABC, transporter WL1483_3036 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) WL1483_3038 ENOG4105C5B carbamate kinase WL1483_3039 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WL1483_304 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) WL1483_3040 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) WL1483_3041 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) WL1483_3042 ENOG4105P8F nudix hydrolase WL1483_3045 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) WL1483_3046 ENOG4108T9J Cdp-alcohol phosphatidyltransferase WL1483_3048 ENOG4108ZQS transposase WL1483_305 ENOG4105CPP Dehydrogenase, E1 component WL1483_3050 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) WL1483_3053 ENOG4107SDZ Galactoside transport system permease protein mglC WL1483_3055 ENOG4105E51 psp operon transcriptional activator WL1483_3056 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WL1483_3057 ENOG4105CIY formyltetrahydrofolate deformylase WL1483_306 ENOG4105GVR general secretion pathway protein D WL1483_3060 ENOG4105UYK outer membrane protein a WL1483_3061 ENOG4105DJV ribulose-phosphate 3-epimerase WL1483_3062 ENOG4105FQ6 thiopurine methyltransferase WL1483_3063 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease WL1483_3065 ENOG4108MVM Transposase WL1483_3067 ENOG4108V1U phospholipid-binding protein WL1483_3069 ENOG4108ZQS transposase WL1483_307 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) WL1483_3071 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase WL1483_3073 ENOG4105KT5 UmuD protein WL1483_3078 ENOG4105CUW cytochrome C-TYPE protein WL1483_3080 ENOG4105Q9Y Universal stress protein WL1483_3087 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WL1483_3089 ENOG4105E2R ROK family WL1483_309 ENOG4105D4A Cell wall formation (By similarity) WL1483_3090 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_3091 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ WL1483_3092 ENOG4105M7P phage repressor WL1483_3093 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) WL1483_3098 ENOG4105DFU Cell wall formation (By similarity) WL1483_3099 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits WL1483_31 ENOG4108ZQS transposase WL1483_310 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) WL1483_3102 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) WL1483_3104 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) WL1483_3105 ENOG4108R6K riboflavin synthase, subunit alpha WL1483_3107 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WL1483_3108 ENOG4105K64 Glycosyl transferase, family 2 WL1483_3111 ENOG4105C26 Dehydrogenase WL1483_3113 ENOG4108Q2J Inner membrane protein YebE WL1483_3114 ENOG4105S66 prophage protein WL1483_3115 ENOG4105BZU Histidine kinase WL1483_3119 ENOG4107QIJ Aconitate hydratase 2 WL1483_3120 ENOG4108J1Q WL1483_3121 ENOG4105WMR Protein CrcB homolog WL1483_3129 ENOG4105E0X reductase WL1483_3130 ENOG4105K8N protein family UPF0079, ATPase WL1483_3132 ENOG4108ZQS transposase WL1483_3134 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WL1483_3138 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WL1483_3141 ENOG4105UYK outer membrane protein a WL1483_3142 ENOG4107Z3H Transcriptional regulator, TetR family WL1483_3143 ENOG4108PCN EamA-like transporter family WL1483_3144 ENOG4107104 thymidine kinase WL1483_3145 ENOG4107S4F acyltransferase, ws dgat mgat WL1483_3147 ENOG4105DQ5 transport system permease protein WL1483_3149 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WL1483_315 ENOG4105UIB (ABC) transporter WL1483_3150 ENOG4105IFJ Histidine kinase WL1483_3153 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WL1483_3155 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal WL1483_3156 ENOG4105K46 50S ribosomal protein l27 WL1483_3158 ENOG4108HRK Histidine kinase WL1483_3159 ENOG4105CUW cytochrome C-TYPE protein WL1483_3160 ENOG4105CIN aminoacyl-histidine dipeptidase WL1483_3161 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) WL1483_3162 ENOG4108IQE Amp-dependent synthetase and ligase WL1483_3165 ENOG4108MVM Transposase WL1483_3168 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 WL1483_3169 ENOG4105C26 Dehydrogenase WL1483_3172 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) WL1483_3173 ENOG4105C5H ABC transporter WL1483_3178 ENOG4108VUY thioesterase Superfamily protein WL1483_3179 ENOG4105E1F short-chain dehydrogenase reductase WL1483_3180 ENOG4108ZQS transposase WL1483_3181 ENOG4105CE4 GlcNAc 6-P deacetylase WL1483_3185 ENOG4105VEJ Heat shock protein WL1483_3187 ENOG4105C0P Mg chelatase subunit ChlI WL1483_3188 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WL1483_3190 ENOG4105BZM domain protein WL1483_3193 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) WL1483_3194 ENOG4106371 Methyltransferase WL1483_3195 ENOG4108EFP Anthranilate synthase component II WL1483_3198 ENOG4105CT7 inner membrane cred family protein WL1483_3199 ENOG4107RZZ dna polymerase iii epsilon subunit WL1483_32 ENOG4105VQ7 Rod shape-determining protein MreD WL1483_320 ENOG4107T8Q Glycosyl transferase (Group 1 WL1483_3200 ENOG4105CKK Glycosyl transferase, family 2 WL1483_3203 ENOG4105VCC 30S ribosomal protein S21 WL1483_3205 ENOG4107WP9 Histidine kinase WL1483_3210 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) WL1483_3211 ENOG4105CDY transcriptional regulatory protein WL1483_3212 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WL1483_3213 ENOG4105KWW Biogenesis protein WL1483_3216 ENOG4108K5H permease YjgP YjgQ family protein WL1483_3218 ENOG4108VVK transcriptional Regulator, AsnC WL1483_3219 ENOG41067SE Tetr family transcriptional regulator WL1483_322 ENOG4105EI2 Pseudouridine synthase WL1483_3220 ENOG4105CE1 Ferrous iron transport protein b WL1483_3221 ENOG4105C8U phosphate abc transporter WL1483_3224 ENOG4105F0N pyrophosphate phospho-hydrolase WL1483_3226 ENOG4108M3R transcriptional activator CadC WL1483_323 ENOG4105D0M Protease HtpX homolog WL1483_3230 ENOG4105C3M thioredoxin reductase WL1483_3232 ENOG4105C8N cysteinyl-tRNA synthetase WL1483_3233 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WL1483_3236 ENOG4105C5H ABC transporter WL1483_3237 ENOG4105EHM Aminoglycoside phosphotransferase WL1483_3238 ENOG4105CJW magnesium transporter WL1483_3240 ENOG4105E0X reductase WL1483_3245 ENOG4105BZG amino acid carrier protein WL1483_3246 ENOG41080Z8 PHOSPHOCARRIER protein WL1483_3247 ENOG4105HEI LysR family (Transcriptional regulator WL1483_3248 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WL1483_325 ENOG41060IM Heme exporter protein WL1483_3252 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WL1483_3253 ENOG4105QNF Outer membrane lipoprotein WL1483_3256 ENOG4105E66 phosphoriboisomerase A WL1483_3257 ENOG4107QS8 (LipO)protein WL1483_3258 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) WL1483_3259 ENOG41090BQ Glutaredoxin WL1483_3260 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) WL1483_3261 ENOG4105D1Q UPF0246 protein WL1483_3263 ENOG4105C7W Xanthine dehydrogenase WL1483_3264 ENOG4105C5H ABC transporter WL1483_3266 ENOG4108UYE Lactoylglutathione lyase WL1483_3267 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) WL1483_3269 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) WL1483_327 ENOG4105D4U had-superfamily hydrolase, subfamily iia WL1483_3270 ENOG4105E3W Two component transcriptional regulator (Winged helix family WL1483_3272 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase WL1483_3274 ENOG4105CFV Tetratricopeptide repeat protein WL1483_3276 ENOG4105ETT transcriptional Regulator, LysR family WL1483_3277 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WL1483_3278 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WL1483_3279 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_3282 ENOG4105E02 MotA TolQ exbB proton channel WL1483_3284 ENOG4108VC8 Peptidase family M23 WL1483_3285 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) WL1483_3290 ENOG4105CGF Aromatic amino acid aminotransferase WL1483_3292 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WL1483_3294 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) WL1483_3295 ENOG4107RUE extracellular solute-binding protein family 1 WL1483_3299 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WL1483_33 ENOG4105C6N Formate acetyltransferase WL1483_3300 ENOG4105E0K tonB-dependent siderophore receptor WL1483_3303 ENOG4105Y49 secretion protein, HlyD family WL1483_3305 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein WL1483_3307 ENOG4105CEY Amp-dependent synthetase and ligase WL1483_331 ENOG410829K Lysine exporter protein (Lyse ygga) WL1483_3312 ENOG4105CXY transporter WL1483_3313 ENOG4105DH7 May be involved in recombination (By similarity) WL1483_3314 ENOG4105JQN Transcriptional regulator WL1483_3316 ENOG4108ZAI phosphatidylglycerophosphatase a WL1483_3317 ENOG4105BZU Histidine kinase WL1483_3319 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) WL1483_332 ENOG4105RH4 Glycine cleavage system transcriptional repressor WL1483_3320 ENOG4105CHR reductase WL1483_3322 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) WL1483_3324 ENOG4107RTD sua5 ycio yrdc ywlc family protein WL1483_3326 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WL1483_3327 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) WL1483_3329 ENOG4108IXY short-chain dehydrogenase reductase WL1483_333 ENOG4105D00 flagellar biosynthetic protein flhB WL1483_3332 ENOG4105D49 3-dehydroquinate synthase WL1483_3334 ENOG4105PQ6 UPF0208 membrane protein WL1483_3335 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WL1483_3336 ENOG4106HNH Acyl-transferase WL1483_3338 ENOG4105BZW Glycerate kinase WL1483_3339 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) WL1483_334 ENOG4105KK7 inner membrane protein YiaW WL1483_3342 ENOG4108ZQS transposase WL1483_3345 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) WL1483_3346 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WL1483_3348 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) WL1483_3351 ENOG4108WZM domain protein WL1483_3353 ENOG4108KQ5 Integrase catalytic subunit WL1483_3354 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation WL1483_3357 ENOG4105C4R Atp-dependent dna helicase WL1483_3358 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase WL1483_3359 ENOG4105D64 Mechanosensitive ion channel WL1483_336 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WL1483_3360 ENOG4107R7I amino acid WL1483_3361 ENOG4108YYD acetyltransferase WL1483_3367 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) WL1483_3368 ENOG4107RCH Diaminopropionate ammonia-lyase WL1483_3369 ENOG4105GAV receptor WL1483_337 ENOG4105W1Y Transcriptional regulator WL1483_3370 ENOG4108KPB Flagellar basal-body rod protein FlgF WL1483_3372 ENOG4105EY8 ABC transporter WL1483_3373 ENOG4105DFD Na H antiporter WL1483_3375 ENOG4105C0B DNA polymerase III (alpha subunit) WL1483_3376 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) WL1483_3378 ENOG4105CRQ synthase (Component I) WL1483_338 ENOG41087YS Phage shock protein A WL1483_3380 ENOG4106428 Protein of unknown function (DUF2496) WL1483_3386 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WL1483_3388 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WL1483_3389 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WL1483_3390 ENOG4105CVP deoxyribo-dipyrimidine photolyase WL1483_3392 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WL1483_3393 ENOG4108NVR Methyl-accepting chemotaxis WL1483_3394 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WL1483_3398 ENOG4105D9N nucleoside WL1483_34 ENOG4105E55 glycerol-3-phosphate acyltransferase WL1483_340 ENOG4105CEE C4-dicarboxylate transporter WL1483_3400 ENOG4105C1J atp-dependent rna helicase WL1483_3401 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase WL1483_3403 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WL1483_3405 ENOG4108HM4 ABC transporter WL1483_3406 ENOG4106RZ4 Peptidase U32 WL1483_3408 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WL1483_3411 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) WL1483_3412 ENOG410600T transposase WL1483_3413 ENOG4107R1I NAD-dependent malic enzyme WL1483_3414 ENOG4105CIC tryptophan-specific transport protein WL1483_3415 ENOG4105CJ2 (LipO)protein WL1483_3416 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WL1483_3419 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) WL1483_3420 ENOG4107QMP dna polymerase iii subunits gamma and tau WL1483_3425 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WL1483_3428 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) WL1483_3431 ENOG4105SYT Methylenetetrahydrofolate reductase WL1483_3432 ENOG4105WH1 Two component transcriptional regulator luxr family WL1483_3433 ENOG4105C0D helicase WL1483_3434 ENOG4108KXH Ybak prolyl-tRNA synthetase associated WL1483_3435 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein WL1483_3436 ENOG4105C2N RNA methyltransferase TrmH family group 3 WL1483_3438 ENOG4108JIR Flagellum-specific ATP synthase WL1483_3440 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WL1483_3442 ENOG4108M3P Membrane WL1483_3444 ENOG4107T6V glycerophosphoryl diester phosphodiesterase WL1483_3446 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WL1483_3447 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) WL1483_345 ENOG4105KT7 mgtC SapB transporter WL1483_3453 ENOG4105CJ3 phosphate transporter WL1483_3454 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WL1483_3455 ENOG4108J1Q WL1483_3456 ENOG4105EP1 Efflux transporter rnd family, mfp subunit WL1483_3458 ENOG4105R8A Heat shock protein WL1483_346 ENOG4105CJP fad dependent oxidoreductase WL1483_3460 ENOG4105C03 ribonuclease WL1483_3461 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) WL1483_3464 ENOG4106IUH DTW domain containing protein WL1483_3465 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) WL1483_3466 ENOG4105PTV Nudix Hydrolase WL1483_3467 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WL1483_3468 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_347 ENOG4108YXG UPF0502 protein WL1483_3471 ENOG4107FW0 short-chain dehydrogenase reductase WL1483_3472 ENOG4108UQ5 membrane protein YcdZ WL1483_3473 ENOG4105DGW oligopeptidase A WL1483_3474 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WL1483_3475 ENOG4105RH4 Glycine cleavage system transcriptional repressor WL1483_3477 ENOG41090WB Transposase is3 is911 WL1483_3478 ENOG4108Z1B Cyclase dehydrase WL1483_348 ENOG4108I9X Isocitrate lyase WL1483_3480 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) WL1483_3481 ENOG4105CR4 methylisocitrate lyase WL1483_3482 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WL1483_3483 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WL1483_3484 ENOG4105N2W Transcriptional regulator WL1483_3486 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family WL1483_3489 ENOG4106TD9 Diguanylate cyclase WL1483_3491 ENOG4105C1B dTDP-glucose 4-6-dehydratase WL1483_3495 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WL1483_3496 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WL1483_3498 ENOG4108Z0T Part of a sulfur-relay system (By similarity) WL1483_3499 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) WL1483_35 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WL1483_3500 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) WL1483_3501 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) WL1483_3502 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WL1483_3505 ENOG4105VF7 tolerance protein WL1483_3506 ENOG4108VIA integral membrane protein WL1483_3507 ENOG4105CHH sulfate transporter WL1483_3509 ENOG4105DU1 integral membrane protein, terc WL1483_3514 ENOG4105K70 DNA-binding protein WL1483_3515 ENOG4105D9R oxidoreductase WL1483_3517 ENOG4105BZA Phosphoglycerate kinase WL1483_3518 ENOG4105EJ2 Transcriptional regulator WL1483_3521 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) WL1483_3522 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase WL1483_3523 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WL1483_3526 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) WL1483_3527 ENOG4108HMX isocitrate dehydrogenase (NADP) WL1483_3529 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) WL1483_3530 ENOG4105F2M alpha beta hydrolase fold-3 domain protein WL1483_3531 ENOG4105D4Y metalloprotease WL1483_3533 ENOG4105CTB Polyprenyl synthetase WL1483_3534 ENOG4105E3W Two component transcriptional regulator (Winged helix family WL1483_3535 ENOG4105VS8 Flagellar biosynthetic protein fliq WL1483_3536 ENOG4105DAN ATP-dependent protease WL1483_3538 ENOG4105DFP Integrase WL1483_3539 ENOG4107QTH restriction modification system DNA specificity domain WL1483_354 ENOG4105II7 pyrroline-5-carboxylate reductase WL1483_3541 ENOG4108MGI Transcriptional regulator WL1483_3542 ENOG4105UQX Mate efflux family protein WL1483_3543 ENOG4105C5F glutamine synthetase WL1483_3545 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) WL1483_3546 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) WL1483_3547 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) WL1483_3548 ENOG4105GBT ABC transporter WL1483_355 ENOG4105CSH Transporter WL1483_3550 ENOG4105CUZ uba thif-type nad fad binding protein WL1483_3554 ENOG4105CYN Serine protein kinase WL1483_3555 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WL1483_3556 ENOG4105DXD 2-methylcitrate dehydratase WL1483_3558 ENOG4105I03 Flagellin WL1483_3559 ENOG4105BZU Histidine kinase WL1483_356 ENOG4107QHF type ii secretion system protein e WL1483_3561 ENOG4105C5Q Transcriptional regulator WL1483_3562 ENOG4105DA4 cytochrome c-type biogenesis protein WL1483_3567 ENOG4105D0A hydroxylase WL1483_3569 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WL1483_3570 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) WL1483_3572 ENOG4105E0F Histidine kinase WL1483_3573 ENOG4105ETE Transcriptional regulator (LacI family WL1483_3579 ENOG4105KNE Phosphatidate cytidylyltransferase WL1483_358 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WL1483_3580 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic WL1483_3581 ENOG4105CWB LysR family transcriptional Regulator WL1483_3582 ENOG4105C4R Atp-dependent dna helicase WL1483_3583 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) WL1483_3584 ENOG4105CA9 Pyruvate kinase WL1483_3585 ENOG4107QRG dna polymerase iii WL1483_3589 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WL1483_3590 ENOG4105F8C transglutaminase domain-containing protein WL1483_3591 ENOG4108HHI Type III secretion system protein WL1483_3593 ENOG4107UUR Chlorohydrolase aminohydrolase WL1483_3595 ENOG4105DJ4 phosphatidylserine decarboxylase WL1483_3597 ENOG4105F8V Hydrolase, tatD family WL1483_3599 ENOG4105E2S oxidase) subunit II WL1483_360 ENOG410682P Hypothetical protein (DUF2513) WL1483_3601 ENOG4107S0N DJ-1 family WL1483_3603 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) WL1483_3604 ENOG4105VNT transposase (IS4 family) protein WL1483_3609 ENOG4105DIQ Transcriptional regulator WL1483_3611 ENOG4108HR6 Dehydrogenase WL1483_3613 ENOG4105CS6 Rhs element vgr protein WL1483_3615 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein WL1483_3616 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) WL1483_3617 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WL1483_3618 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_3619 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_3620 ENOG4107QZF nitrite reductase NADPH large subunit WL1483_3621 ENOG4105E4C Lytic transglycosylase catalytic WL1483_3624 ENOG4108M1A Chitin-binding protein WL1483_3625 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) WL1483_3627 ENOG4108NVR Methyl-accepting chemotaxis WL1483_3628 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) WL1483_3629 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WL1483_3631 ENOG4105FR1 rard protein WL1483_3632 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) WL1483_3633 ENOG4108UGV hypoxanthine phosphoribosyltransferase WL1483_3635 ENOG4105UBK short-chain dehydrogenase reductase WL1483_3636 ENOG4108J1Q WL1483_3637 ENOG4108EKI Dehydrogenase WL1483_3638 ENOG4105W1I UPF0253 protein WL1483_3639 ENOG4105C5Q Transcriptional regulator WL1483_364 ENOG4105CY3 ABC transporter, permease WL1483_3640 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) WL1483_3641 ENOG4108KQ5 Integrase catalytic subunit WL1483_3642 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WL1483_3644 ENOG4108ZQS transposase WL1483_3645 ENOG4105MA0 exported protein WL1483_3646 ENOG4105CTQ phosphohexokinase WL1483_365 ENOG41069NU Nitroreductase WL1483_3650 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) WL1483_3653 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) WL1483_3655 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) WL1483_3656 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WL1483_3658 ENOG4105C59 p-type ATPase WL1483_3659 ENOG4108I5U Uridine phosphorylase WL1483_3660 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) WL1483_3663 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WL1483_3664 ENOG4105F0Z galactose-1-phosphate uridylyltransferase WL1483_3667 ENOG4105C5E polysaccharide biosynthesis protein WL1483_3668 ENOG4108Z43 UPF0250 protein WL1483_3669 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) WL1483_367 ENOG4108R3D Electron transport complex WL1483_3671 ENOG4108MVM Transposase WL1483_3674 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WL1483_3677 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) WL1483_3679 ENOG41076MN Phosphoesterase, PA-phosphatase related WL1483_3682 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WL1483_3683 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) WL1483_3684 ENOG4108V1T peptidylprolyl cis-trans isomerase WL1483_3685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WL1483_3686 ENOG4105EJG cellulose synthase WL1483_3687 ENOG4105CWM branched-chain amino acid transport system II carrier protein WL1483_3689 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) WL1483_3690 ENOG4108MVM Transposase WL1483_3691 ENOG4105IW6 Carbamoyltransferase WL1483_3692 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WL1483_3693 ENOG4105CGF Aromatic amino acid aminotransferase WL1483_3694 ENOG4108JQ1 Dehydrogenase WL1483_3695 ENOG4105C2M dna polymerase I WL1483_3697 ENOG4105CXY transporter WL1483_37 ENOG4105WQI isochorismatase WL1483_3701 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WL1483_3702 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WL1483_3706 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) WL1483_3708 ENOG4105DRB nucleoside-specific channel-forming protein WL1483_3710 ENOG4105EEI dihydropteroate synthase WL1483_3711 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) WL1483_3712 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 WL1483_3717 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) WL1483_3719 ENOG4105EJC lysr family transcriptional regulator WL1483_3721 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) WL1483_3729 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WL1483_3731 ENOG4105VVZ metal-binding protein WL1483_3733 ENOG4108HRK Histidine kinase WL1483_3736 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WL1483_3737 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) WL1483_3739 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) WL1483_374 ENOG4108SV3 Tmao reductase system periplasmic protein tort WL1483_3745 ENOG41080HT Transcriptional regulator, arsr family WL1483_3746 ENOG4105DN3 alpha-2-macroglobulin domain protein WL1483_3747 ENOG4107RE1 Inosine-guanosine kinase WL1483_375 ENOG4105WWK YheO domain protein WL1483_3750 ENOG4108NIW Leucine export protein LeuE WL1483_3752 ENOG41062JF Transcriptional regulator WL1483_3755 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WL1483_3756 ENOG4105Y4Z Outer Membrane Lipoprotein WL1483_3757 ENOG4105BZ8 glutamate synthase WL1483_3759 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) WL1483_3761 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) WL1483_3764 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) WL1483_3766 ENOG4105MIR Phenylalanine 4-monooxygenase WL1483_3767 ENOG4107RBB ABC transporter, permease WL1483_3768 ENOG4108HIY periplasmic WL1483_3769 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WL1483_3770 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) WL1483_3771 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) WL1483_3778 ENOG4105XEA Tetr family transcriptional regulator WL1483_3779 ENOG4108WC5 Alpha Beta Hydrolase Fold protein WL1483_378 ENOG4105CHH sulfate transporter WL1483_3782 ENOG4105DA4 cytochrome c-type biogenesis protein WL1483_3783 ENOG4108JQ7 (ABC) transporter WL1483_3787 ENOG4108MVM Transposase WL1483_3788 ENOG4105DTJ flagellar hook-associated protein WL1483_3789 ENOG4105K8R UPF0145 protein WL1483_3791 ENOG4105E09 nadh pyrophosphatase WL1483_3794 ENOG4108NIW Leucine export protein LeuE WL1483_3797 ENOG4108ZGC gaf domain protein WL1483_3799 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WL1483_38 ENOG4105C1J atp-dependent rna helicase WL1483_380 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) WL1483_3800 ENOG4105CGU Enoyl-CoA hydratase WL1483_3801 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) WL1483_3804 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WL1483_3805 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) WL1483_3808 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WL1483_3809 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WL1483_3811 ENOG4105C6K Malic enzyme WL1483_3814 ENOG4105DBV ornithine carbamoyltransferase WL1483_3816 ENOG4105FDK ABC transporter WL1483_3817 ENOG4108TPP exopolysaccharide synthesis WL1483_3818 ENOG41090Y2 cytochrome C WL1483_3821 ENOG4105CMS peptidase U62, modulator of DNA gyrase WL1483_3823 ENOG4105BZ8 glutamate synthase WL1483_3824 ENOG4108JIR Flagellum-specific ATP synthase WL1483_3827 ENOG41061WM D-Alanyl-D-Alanine WL1483_3828 ENOG4105E14 MotA TolQ exbB proton channel WL1483_383 ENOG4105DXN mazG family WL1483_3830 ENOG4107WCA isomerase WL1483_3831 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WL1483_3833 ENOG4105E2D ec 3.2.1.52 WL1483_3835 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WL1483_3836 ENOG4105EWC Purine nucleoside phosphorylase WL1483_3838 ENOG4108MA4 Peptidase M66 WL1483_3843 ENOG4105D7Q type ii secretion system WL1483_3847 ENOG4105EJG cellulose synthase WL1483_3849 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WL1483_3851 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) WL1483_3853 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WL1483_3857 ENOG4107QMS site-determining protein WL1483_3858 ENOG4108BGM Quinol dehydrogenase periplasmic component WL1483_386 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) WL1483_3861 ENOG4105DD5 Flagellar motor switch protein WL1483_3863 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) WL1483_3864 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) WL1483_3865 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) WL1483_3866 ENOG4105BZU Histidine kinase WL1483_3867 ENOG4108MVM Transposase WL1483_3868 ENOG4105E0K tonB-dependent siderophore receptor WL1483_387 ENOG4108XTF Outer Membrane Lipoprotein WL1483_3871 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WL1483_3873 ENOG4108ZT0 50S ribosomal protein l17 WL1483_3874 ENOG4108JU6 CBS domain protein WL1483_3878 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family WL1483_3881 ENOG4105KB2 stringent starvation protein b WL1483_3883 ENOG4105M85 Bola protein WL1483_3884 ENOG4105RX8 Protein of unknown function (DUF1523) WL1483_3885 ENOG4106WH9 Protein of unknown function (DUF2753) WL1483_3887 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family WL1483_3889 ENOG4105DC7 peptidase M24 WL1483_3889 ENOG4105DC7 peptidase M24 WL1483_389 ENOG4107YZP Rhodanese domain protein WL1483_3891 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WL1483_3898 ENOG4108I6A alcohol dehydrogenase WL1483_3899 ENOG4106N3A copper homeostasis protein cutc WL1483_3902 ENOG4105K9H YciI-like protein WL1483_3903 ENOG4105CS2 ec 3.2.1.21 WL1483_3905 ENOG4105D4P Coproporphyrinogen iii oxidase WL1483_3906 ENOG4105CI1 PTS System WL1483_3907 ENOG4105KVH Transcriptional regulator WL1483_3908 ENOG4105C2J ABC transporter WL1483_3909 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) WL1483_3911 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WL1483_3912 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase WL1483_3913 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WL1483_3914 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WL1483_3915 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WL1483_3916 ENOG4105WZK nitrite reductase NADPH small subunit WL1483_3917 ENOG4105EM7 Selenocysteine-specific translation elongation factor WL1483_3918 ENOG4105F2V VRR-NUC domain-containing protein WL1483_3919 ENOG4105C26 Dehydrogenase WL1483_392 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) WL1483_3921 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase WL1483_3922 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) WL1483_3924 ENOG4108ZIG UPF0231 protein WL1483_3925 ENOG4105E96 Colicin v production protein WL1483_3926 ENOG4105D00 flagellar biosynthetic protein flhB WL1483_3927 ENOG4105DNI Converts SHCHC to OSB (By similarity) WL1483_3929 ENOG4107QK7 reductase WL1483_393 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase WL1483_3931 ENOG4105C85 amino acid WL1483_3933 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WL1483_3934 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) WL1483_3935 ENOG4105W0Z cytoplasmic protein WL1483_3936 ENOG4107K5X Membrane-bound metal-dependent hydrolase WL1483_3937 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WL1483_3938 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WL1483_3941 ENOG4105CJP fad dependent oxidoreductase WL1483_3943 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WL1483_3945 ENOG4108J1Q WL1483_3946 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WL1483_3947 ENOG4105C3R Methionine synthase WL1483_3949 ENOG4108MVM Transposase WL1483_3950 ENOG4105BZU Histidine kinase WL1483_3952 ENOG4105BZU Histidine kinase WL1483_3953 ENOG4108V3W Chemotaxis protein, CheW WL1483_3955 ENOG4108J1Q WL1483_3956 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WL1483_3957 ENOG41080IJ Diacylglycerol kinase WL1483_3958 ENOG4105CJP fad dependent oxidoreductase WL1483_3959 ENOG4105KQ5 peptidylprolyl cis-trans isomerase WL1483_3960 ENOG4108J1Q WL1483_3963 ENOG4105N42 UPF0307 protein WL1483_3964 ENOG4108MVM Transposase WL1483_3965 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) WL1483_3967 ENOG4105WN5 stage II sporulation protein WL1483_3969 ENOG4105KJB cyd operon protein YbgE WL1483_3970 ENOG4105M2J Glutaredoxin WL1483_3971 ENOG4105KT5 UmuD protein WL1483_3972 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WL1483_3973 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WL1483_3974 ENOG4105CHH sulfate transporter WL1483_3977 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WL1483_3980 ENOG4107SVH Potassium channel protein WL1483_3981 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) WL1483_3982 ENOG4108TSE Transferase WL1483_3984 ENOG4105C0W non-ribosomal peptide synthetase WL1483_3985 ENOG4105DZ2 Transcriptional regulator WL1483_3986 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related WL1483_3994 ENOG4105VZ9 UPF0235 protein WL1483_3995 ENOG4105CK2 sodium dicarboxylate symporter WL1483_3996 ENOG4105DR5 peptidase WL1483_3997 ENOG4105DUM transcriptional regulator, lysR family WL1483_3999 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 WL1483_4 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WL1483_40 ENOG4105MWK D-amino acid dehydrogenase, small subunit WL1483_4000 ENOG4107FKK extracellular solute-binding protein family 1 WL1483_4001 ENOG4107T9C Alpha amylase catalytic region WL1483_4002 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) WL1483_4003 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WL1483_4005 ENOG4105CN7 Flagellar biosynthetic protein FliP WL1483_4006 ENOG4108Y73 Membrane WL1483_4007 ENOG4108NNZ chitinase WL1483_4009 ENOG41090R7 Ferric uptake WL1483_4010 ENOG4105VMP Transcriptional regulator WL1483_4012 ENOG4105CP9 extracellular ligand-binding receptor WL1483_4015 ENOG4108JQ2 peptide transport system atp-binding protein WL1483_4019 ENOG4105E0C molybdate abc transporter WL1483_402 ENOG4107QIZ NADH dehydrogenase WL1483_4023 ENOG4108ZG0 Ompa motb domain protein WL1483_4025 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) WL1483_4028 ENOG4107UFS subunit j WL1483_4029 ENOG4105EQK -acetyltransferase WL1483_4031 ENOG4105GXZ Ferredoxin-type protein NapH WL1483_4032 ENOG4108ZQS transposase WL1483_4035 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WL1483_4038 ENOG4108XKW General secretion pathway protein C WL1483_4039 ENOG4108S3P Sporulation domain protein WL1483_4040 ENOG4105CVE Lytic murein transglycosylase WL1483_4041 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WL1483_4043 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) WL1483_4044 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WL1483_4049 ENOG4105CK7 Sodium proline symporter WL1483_4050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_4051 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) WL1483_4053 ENOG4108JQ9 ABC transporter WL1483_4054 ENOG4105HDK L-asparaginase WL1483_4055 ENOG4105CMR udp-glucose 4-epimerase WL1483_4057 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) WL1483_4058 ENOG4105F1A Pyruvate formate-lyase WL1483_4059 ENOG4108HRK Histidine kinase WL1483_406 ENOG4107ZVW dihydroneopterin aldolase WL1483_4060 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) WL1483_4062 ENOG4108Z4U Ferredoxin WL1483_4063 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WL1483_4066 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WL1483_4069 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WL1483_407 ENOG41074DU domain protein WL1483_4070 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) WL1483_4073 ENOG4108MVM Transposase WL1483_4076 ENOG4105BZU Histidine kinase WL1483_4077 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WL1483_4078 ENOG4105VYA Uncharacterized conserved protein (DUF2132) WL1483_4079 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme WL1483_408 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WL1483_4080 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) WL1483_4081 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) WL1483_4083 ENOG4105EJ9 Membrane WL1483_4084 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WL1483_4086 ENOG4108M1A Chitin-binding protein WL1483_4087 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WL1483_4088 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) WL1483_409 ENOG41065U4 response regulator WL1483_4092 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) WL1483_4093 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) WL1483_4097 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WL1483_4100 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) WL1483_4103 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) WL1483_4104 ENOG4107QI1 Mate efflux family protein WL1483_4105 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WL1483_4109 ENOG4108J1Q WL1483_411 ENOG4105CNN ABC, transporter WL1483_4110 ENOG41087YS Phage shock protein A WL1483_4117 ENOG4108F3G Type I restriction-modification system, R subunit WL1483_4118 ENOG41077A9 carbonic anhydrase WL1483_4120 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) WL1483_4127 ENOG4105JC1 sterol-binding domain protein WL1483_4129 ENOG4107YZX Universal stress protein WL1483_413 ENOG4105DN3 alpha-2-macroglobulin domain protein WL1483_4130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WL1483_4132 ENOG4106FVC RNA methyltransferase WL1483_4133 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) WL1483_4134 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) WL1483_4135 ENOG4105KZ7 phosphocarrier protein hpr WL1483_4138 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WL1483_4139 ENOG4106WF9 DNA-binding transcriptional regulator TorR WL1483_414 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) WL1483_4141 ENOG4107QX9 Thiol disulfide interChange protein WL1483_4142 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) WL1483_4144 ENOG4105DFA alanine racemase domain protein WL1483_4146 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WL1483_4147 ENOG4105PW4 Sugar fermentation stimulation protein homolog WL1483_4148 ENOG4105F27 Major Facilitator WL1483_4149 ENOG410600T transposase WL1483_415 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WL1483_4150 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit WL1483_4151 ENOG4105Y3E Modulates RecA activity (By similarity) WL1483_4155 ENOG4108ZQS transposase WL1483_4156 ENOG4105VFB Binds the 23S rRNA (By similarity) WL1483_416 ENOG4107IFA Lipase (EC 3.1.1.3) WL1483_4161 ENOG4105UYK outer membrane protein a WL1483_4163 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WL1483_4168 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters WL1483_417 ENOG4107W52 maltose operon periplasmic protein WL1483_4170 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WL1483_4171 ENOG4105VPB 50S ribosomal protein L30 WL1483_4172 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) WL1483_4173 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) WL1483_4175 ENOG4105CFQ glutamine synthetase WL1483_4177 ENOG4105CVI Transcriptional regulator WL1483_4179 ENOG4105C2I pirin domain protein WL1483_4182 ENOG4105D4X repressor WL1483_4184 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WL1483_4186 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) WL1483_4187 ENOG4105VKU nucleicacid-binding protein WL1483_4188 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) WL1483_419 ENOG4105VRX Protein slyX homolog WL1483_4191 ENOG4105C2C drug resistance transporter, Bcr CflA WL1483_4192 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WL1483_4195 ENOG4105D81 ABC transporter, permease WL1483_4196 ENOG4105D2N Aldolase WL1483_4199 ENOG4105EX9 Membrane WL1483_42 ENOG4105CMT Dihydroxyacetone kinase WL1483_420 ENOG4105D6Z AFG1 family ATPase WL1483_4201 ENOG4105VS8 Flagellar biosynthetic protein fliq WL1483_4202 ENOG4105C4M (Ubiquinol oxidase) subunit I WL1483_4203 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) WL1483_4206 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WL1483_4208 ENOG4105D3R alkyl hydroperoxide reductase WL1483_421 ENOG41061GZ Protein of unknown function (DUF1107) WL1483_4213 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) WL1483_4214 ENOG4105EJC lysr family transcriptional regulator WL1483_4217 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) WL1483_4218 ENOG4108Z5K methylglyoxal synthase WL1483_422 ENOG4105BZU Histidine kinase WL1483_4220 ENOG4105CBN LysR family transcriptional regulator WL1483_4221 ENOG4105G5H Membrane WL1483_4223 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WL1483_4225 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) WL1483_4226 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WL1483_4228 ENOG4108P2H Inner membrane protein YjiG WL1483_4229 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) WL1483_423 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WL1483_4230 ENOG4108RMJ sensory transduction regulator WL1483_4232 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WL1483_4234 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase WL1483_4236 ENOG4105EAB amino acid AbC transporter WL1483_424 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) WL1483_4240 ENOG4108YXG UPF0502 protein WL1483_4242 ENOG4105EGS Mechanosensitive ion channel WL1483_4245 ENOG4108UM1 dedA family WL1483_425 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) WL1483_4251 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) WL1483_4253 ENOG4105DA5 (ABC) transporter WL1483_4257 ENOG4108J1Q WL1483_4262 ENOG4105D52 delta-aminolevulinic acid dehydratase WL1483_4263 ENOG4105XIQ Protein of unknown function (DUF2517) WL1483_4266 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WL1483_4269 ENOG4105DU0 nucleoside hydrolase WL1483_4278 ENOG4108K81 inner membrane protein YghB WL1483_4279 ENOG4108ZC9 flagellar basal-body rod protein flgc WL1483_4280 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) WL1483_4284 ENOG4105CSX c4-dicarboxylate anaerobic carrier WL1483_4285 ENOG4105DFP Integrase WL1483_4288 ENOG4108BY2 phosphohistidine phosphatase WL1483_4290 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) WL1483_4291 ENOG4107G87 m6 family metalloprotease domain protein WL1483_4292 ENOG4105D01 (LipO)protein WL1483_4294 ENOG4105GVR general secretion pathway protein D WL1483_4296 ENOG4105VQK sigma E regulatory protein, MucB RseB WL1483_4297 ENOG4105D19 Role in flagellar biosynthesis (By similarity) WL1483_4299 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) WL1483_4300 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) WL1483_4302 ENOG4105CEY Amp-dependent synthetase and ligase WL1483_4303 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) WL1483_4305 ENOG4105NXH GreA GreB family elongation factor WL1483_4307 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_4308 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WL1483_4309 ENOG4105C3G gtp-binding protein WL1483_4310 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) WL1483_4311 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) WL1483_4313 ENOG4107QHF type ii secretion system protein e WL1483_4315 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) WL1483_4316 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) WL1483_4317 ENOG4108ZQS transposase WL1483_4320 ENOG4105CD8 aminopeptidase N WL1483_4321 ENOG4105EAC phosphoserine phosphatase WL1483_4322 ENOG4108J1Q WL1483_4324 ENOG4105WP7 tRNA pseudouridine synthase C WL1483_4325 ENOG4108J1Q WL1483_433 ENOG4105DIJ Phosphoethanolamine transferase WL1483_4330 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WL1483_4331 ENOG4105ISI outer membrane protein, OMPP1 FadL TodX family WL1483_4333 ENOG4105C44 Serine transporter WL1483_4334 ENOG4105CGY Dna recombination protein WL1483_4335 ENOG410829K Lysine exporter protein (Lyse ygga) WL1483_4338 ENOG4105CKW Inner membrane protein yedI WL1483_4340 ENOG4107RGH Aldehyde dehydrogenase WL1483_4343 ENOG4105CV1 Transketolase (EC 2.2.1.1) WL1483_4347 ENOG4105C3J Cysteine desulfurase WL1483_4349 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WL1483_435 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) WL1483_4350 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) WL1483_4351 ENOG4105D1V cellulose synthase operon protein YhjU WL1483_4353 ENOG4105SUV lipoprotein YgdR WL1483_4355 ENOG410631K Membrane WL1483_4356 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) WL1483_4357 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WL1483_4358 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) WL1483_4363 ENOG4105JAB phenazine biosynthesis protein, phzf family WL1483_4368 ENOG4105KTH gatB Yqey WL1483_437 ENOG4107T8T UPF0173 metal-dependent hydrolase WL1483_4378 ENOG4108W1A pseudouridine synthase WL1483_438 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WL1483_4388 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WL1483_44 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WL1483_440 ENOG4105D1H recombination factor protein RarA WL1483_4403 ENOG4105C5I Dehydrogenase WL1483_4408 ENOG4107835 probably involved in intracellular septation (By similarity) WL1483_441 ENOG4105CZE histidine utilization repressor WL1483_4413 ENOG4105BZU Histidine kinase WL1483_4418 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR WL1483_442 ENOG4108IQE Amp-dependent synthetase and ligase WL1483_4423 ENOG41090A4 Pterin carbinolamine dehydratase WL1483_4428 ENOG4107SSZ Phosphatase WL1483_443 ENOG4105CH7 arginosuccinase WL1483_4443 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WL1483_4448 ENOG4105C1G acyl-Coa dehydrogenase WL1483_445 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WL1483_4453 ENOG4107XM3 UPF0442 protein WL1483_4458 ENOG4105D9N nucleoside WL1483_446 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) WL1483_4463 ENOG4105DGU Histone deacetylase WL1483_447 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase WL1483_4473 ENOG4105ERG peptidase m48, ste24p WL1483_4478 ENOG4105KME endoribonuclease L-psp WL1483_448 ENOG4105E27 serine threonine protein kinase WL1483_4483 ENOG4107V40 secretion protein, HlyD family WL1483_4488 ENOG4108Z03 MAF-like protein WL1483_449 ENOG4105RG0 Membrane WL1483_4498 ENOG4108RMU ferritin dps family protein WL1483_45 ENOG4108ZQS transposase WL1483_450 ENOG4105C5Q Transcriptional regulator WL1483_4503 ENOG4105F1J Homogentisate 1,2-dioxygenase WL1483_4508 ENOG4107QQ0 gntp family WL1483_4518 ENOG4105CVR type I restriction-modification system WL1483_452 ENOG4105ETT transcriptional Regulator, LysR family WL1483_4523 ENOG4107FS9 Membrane WL1483_4528 ENOG4105RKW reductase (By WL1483_453 ENOG4105C5Q Transcriptional regulator WL1483_4533 ENOG4105VYW UPF0251 protein WL1483_4538 ENOG4105D9N nucleoside WL1483_4543 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_4548 ENOG4105CEY Amp-dependent synthetase and ligase WL1483_455 ENOG4105BZU Histidine kinase WL1483_4558 ENOG4105BZU Histidine kinase WL1483_4563 ENOG4105D0C transport protein WL1483_4568 ENOG4105DIT ErfK YbiS YcfS YnhG family protein WL1483_457 ENOG4105C38 Glycyl-tRNA synthetase beta subunit WL1483_4573 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WL1483_4578 ENOG4105EN6 Membrane WL1483_4583 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) WL1483_4588 ENOG4105BZG amino acid carrier protein WL1483_459 ENOG4105E4G Type IV pilus WL1483_4598 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) WL1483_46 ENOG4105DQ5 transport system permease protein WL1483_460 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) WL1483_4603 ENOG4105C8P )-transporter WL1483_4608 ENOG4105CVR type I restriction-modification system WL1483_4613 ENOG4105VP0 transcriptional regulator, lysR family WL1483_462 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) WL1483_4623 ENOG4107IX6 phosphate transport regulator WL1483_4628 ENOG4105HBR Rna-binding protein WL1483_463 ENOG4105DJF DNA polymerase III, delta' subunit WL1483_4633 ENOG4105NAU thioesterase Superfamily protein WL1483_4638 ENOG4108YGG dna repair protein WL1483_4643 ENOG4105K59 histidine triad (HIT) protein WL1483_4648 ENOG4105BZS acriflavin resistance protein WL1483_4653 ENOG4105EV9 Alpha Beta Hydrolase WL1483_4658 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_466 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor WL1483_4663 ENOG4105EE5 Membrane protein terC WL1483_4668 ENOG4108NEV two component transcriptional regulator, LytTR family WL1483_4678 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WL1483_4683 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase WL1483_4688 ENOG41090JD Blue (Type 1) copper domain protein WL1483_469 ENOG4108RPN Protein smg homolog WL1483_4693 ENOG4105D3Y Na H antiporter WL1483_4698 ENOG4105H2K paraquat-inducible protein a WL1483_470 ENOG4108J1Q WL1483_4708 ENOG4105CJ3 phosphate transporter WL1483_4713 ENOG4105CHU acetyl-coa acetyltransferase WL1483_4718 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase WL1483_4723 ENOG4105PZ7 Baseplate assembly protein WL1483_4728 ENOG4105K5B UPF0225 protein WL1483_4733 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_4743 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_4748 ENOG4105C1G acyl-Coa dehydrogenase WL1483_475 ENOG4108J1Q WL1483_4753 ENOG4105D0C transport protein WL1483_476 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) WL1483_4763 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WL1483_4768 ENOG4105RKW reductase (By WL1483_4778 ENOG4108VPT UPF0234 protein WL1483_478 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) WL1483_4783 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein WL1483_4788 ENOG4106V8H Nucleoid-associated protein WL1483_479 ENOG4107RM6 sulfurtransferase WL1483_4793 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein WL1483_4798 ENOG4105V1F Fermentation respiration switch protein WL1483_480 ENOG4107QZM n-acetylglutamate synthase WL1483_4803 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_4808 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) WL1483_481 ENOG4105D38 putrescine abc transporter WL1483_4813 ENOG4105CUW cytochrome C-TYPE protein WL1483_4818 ENOG4105EQR Transposase IS116 IS110 IS902 WL1483_482 ENOG4105CFH Aspartokinase WL1483_4828 ENOG4105D3R alkyl hydroperoxide reductase WL1483_4833 ENOG4105C10 Electron transfer flavoprotein WL1483_4838 ENOG4105VNG YcgL domain-containing protein WL1483_484 ENOG4105C0R drug resistance transporter emrb qaca subfamily WL1483_4843 ENOG4105CFH Aspartokinase WL1483_4848 ENOG4105D9N nucleoside WL1483_485 ENOG4108K01 transcriptional regulator WL1483_4853 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WL1483_4858 ENOG4105BZU Histidine kinase WL1483_4863 ENOG4108UPT UPF0178 protein WL1483_4868 ENOG4105DWD nucleoside recognition domain protein WL1483_4873 ENOG4105CH6 catalase WL1483_4883 ENOG4105DZ0 fad dependent oxidoreductase WL1483_489 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WL1483_49 ENOG4107R08 Integrase WL1483_490 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) WL1483_4908 ENOG4108IQE Amp-dependent synthetase and ligase WL1483_4913 ENOG4105DYS nad(p)h dehydrogenase (quinone) WL1483_4918 ENOG4108UQQ Electron transport complex WL1483_492 ENOG4108MVM Transposase WL1483_4923 ENOG4105KA0 thioesterase Superfamily protein WL1483_4928 ENOG4105C1G acyl-Coa dehydrogenase WL1483_493 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WL1483_4933 ENOG4108DG9 Smr protein MutS2 WL1483_4938 ENOG4105EMU Dehydrogenase WL1483_494 ENOG4108TGY Glutathione S-transferase WL1483_4943 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) WL1483_4948 ENOG4105XW2 UPF0263 protein WL1483_495 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WL1483_4953 ENOG4105M5K heptosyltransferase WL1483_496 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WL1483_497 ENOG4105K5M 30s ribosomal protein S16 WL1483_4973 ENOG4105W4M Transport-associated protein WL1483_4978 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WL1483_4988 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WL1483_4993 ENOG4108UW5 maltose o-acetyltransferase WL1483_4998 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) WL1483_50 ENOG4108MJ5 VirK protein WL1483_5003 ENOG4105N5Z UPF0267 protein WL1483_5008 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WL1483_501 ENOG4108ZNX Heat shock protein WL1483_5013 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) WL1483_5018 ENOG4105DZB Electron transport complex WL1483_502 ENOG4105WPR Transcriptional regulator, ARAC family WL1483_5023 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_503 ENOG4107QUT magnesium and cobalt transport protein CorA WL1483_5033 ENOG4106K28 UPF0283 membrane protein WL1483_5038 ENOG4106WTF Glycosyl transferase, family 2 WL1483_5043 ENOG41069H0 dihydroorotase EC 3.5.2.3 WL1483_505 ENOG4105CMQ Chloride channel WL1483_506 ENOG4107SEY Conserved Protein WL1483_507 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WL1483_510 ENOG4105HA9 of methanol dehydrogenase type WL1483_512 ENOG4105CI1 PTS System WL1483_515 ENOG4105E9H Lytic Murein transglycosylase WL1483_516 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) WL1483_517 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding WL1483_52 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) WL1483_520 ENOG4105CS9 pantothenic acid kinase WL1483_521 ENOG4105EAC phosphoserine phosphatase WL1483_524 ENOG4108ZQS transposase WL1483_526 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) WL1483_528 ENOG4105VNT transposase (IS4 family) protein WL1483_529 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_53 ENOG4107RSM transcriptional regulator WL1483_530 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein WL1483_532 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase WL1483_533 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WL1483_539 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WL1483_54 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component WL1483_541 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) WL1483_543 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WL1483_544 ENOG4105DR8 Membrane WL1483_546 ENOG4105CFH Aspartokinase WL1483_55 ENOG4105NNH LexA regulated protein WL1483_550 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) WL1483_552 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) WL1483_553 ENOG4105D7Q type ii secretion system WL1483_56 ENOG4105C5I Dehydrogenase WL1483_560 ENOG4105JJR Histidine kinase WL1483_562 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) WL1483_568 ENOG4107QKA exodeoxyribonuclease V beta WL1483_569 ENOG4107QSI ABC, transporter WL1483_57 ENOG4105DSP amino acid AbC transporter WL1483_571 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WL1483_572 ENOG4105DGN Electron transport complex WL1483_573 ENOG4105DD7 kinase (PfkB family WL1483_577 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WL1483_579 ENOG41063ZK Transcriptional Regulator AraC Family WL1483_58 ENOG4105SUU thioesterase domain WL1483_582 ENOG4105NWN ApaG protein WL1483_585 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WL1483_588 ENOG4108UQY Iron-storage protein WL1483_589 ENOG4105DSY exodeoxyribonuclease V, gamma WL1483_591 ENOG4105ED1 spovr family WL1483_592 ENOG4105DHQ Histidine kinase WL1483_596 ENOG41062P1 Diguanylate cyclase phosphodiesterase WL1483_597 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WL1483_600 ENOG4105EGS Mechanosensitive ion channel WL1483_605 ENOG4105DQF Hydrolase WL1483_606 ENOG4108W5M transcriptional regulator WL1483_607 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WL1483_608 ENOG4105D0Y UPF0227 protein WL1483_61 ENOG4108ZAF Molybdopterin WL1483_610 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) WL1483_613 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase WL1483_617 ENOG4105VEQ Cold shock protein WL1483_619 ENOG4105CNT hydrolase family 2 WL1483_62 ENOG4105DAA L-lactate WL1483_620 ENOG4105CQB FAD linked oxidase domain protein WL1483_623 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WL1483_624 ENOG4108ZQS transposase WL1483_627 ENOG4108HUF Transporter WL1483_628 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WL1483_629 ENOG4105CR8 Transcriptional regulator WL1483_63 ENOG4107QTF adenylosuccinate lyase WL1483_631 ENOG4108KX4 response regulator WL1483_632 ENOG41075W9 High frequency lysogenization protein HflD homolog WL1483_634 ENOG4107PU6 Membrane WL1483_635 ENOG4105N1P Ferredoxin-type protein WL1483_638 ENOG4105XA0 heptosyltransferase ii WL1483_639 ENOG4108DBC nitroreductase WL1483_64 ENOG4105CQZ Histidine kinase WL1483_640 ENOG4105D3A purine nucleoside phosphorylase DeoD-type WL1483_641 ENOG4105C0D helicase WL1483_642 ENOG4105BZU Histidine kinase WL1483_644 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WL1483_647 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WL1483_648 ENOG4105BZU Histidine kinase WL1483_650 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WL1483_654 ENOG4107R1I NAD-dependent malic enzyme WL1483_655 ENOG4105ETT transcriptional Regulator, LysR family WL1483_656 ENOG4108V6E Cell division protein mraZ WL1483_658 ENOG4105DHT Metal Dependent Phosphohydrolase WL1483_66 ENOG4105KPV Transcriptional regulator WL1483_660 ENOG4105ED4 portal protein WL1483_661 ENOG410804X Transcriptional regulator WL1483_662 ENOG4105ECF c-methyltransferase WL1483_664 ENOG4106PMH Extracellular solute-binding protein family 3 WL1483_669 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WL1483_670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WL1483_672 ENOG4105E9H Lytic Murein transglycosylase WL1483_673 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WL1483_675 ENOG4107QSI ABC, transporter WL1483_677 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WL1483_681 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WL1483_683 ENOG4105BZ8 glutamate synthase WL1483_685 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WL1483_687 ENOG4106TD9 Diguanylate cyclase WL1483_688 ENOG4105CRP Part of the ABC transporter FtsEX involved in WL1483_689 ENOG4105CSA Coproporphyrinogen iii oxidase WL1483_690 ENOG4105CNI cell division protein FtsW WL1483_693 ENOG4105E2D ec 3.2.1.52 WL1483_694 ENOG4105BZU Histidine kinase WL1483_695 ENOG4105MYG DNA polymerase iii, chi subunit WL1483_696 ENOG4105CB5 ATP-dependent DNA helicase recG WL1483_698 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) WL1483_7 ENOG4107XSU flagellar motor protein motb WL1483_70 ENOG4108TFM Kinase, PfkB family WL1483_701 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WL1483_702 ENOG4108USZ hydrogenase WL1483_703 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WL1483_704 ENOG4105MDZ Transcriptional activator rfaH WL1483_706 ENOG4105DP0 ferredoxin-NADP reductase WL1483_707 ENOG4105DSB aldose 1-epimerase WL1483_711 ENOG4106HK8 GPR1 FUN34 yaaH family protein WL1483_712 ENOG4105BZ9 Cytochrome C oxidase, subunit I WL1483_714 ENOG4108ZQS transposase WL1483_715 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) WL1483_716 ENOG4105DKK Benzoate WL1483_717 ENOG4108UV7 flagellar protein motX WL1483_718 ENOG4108R96 Methyltransferase, YaeB family WL1483_720 ENOG4107R1I NAD-dependent malic enzyme WL1483_721 ENOG4105UYK outer membrane protein a WL1483_722 ENOG4105D5Q Arginine ornithine antiporter WL1483_723 ENOG41081XQ Conserved Protein WL1483_724 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WL1483_725 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR WL1483_727 ENOG4105CZX twitching motility protein WL1483_728 ENOG4105CJW magnesium transporter WL1483_729 ENOG4105EPW hflc protein WL1483_73 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WL1483_731 ENOG4105E2X shikimate dehydrogenase WL1483_732 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WL1483_733 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WL1483_735 ENOG4108Z9I -acetyltransferase WL1483_738 ENOG4108KQ5 Integrase catalytic subunit WL1483_739 ENOG4108Z4V iron-sulfur cluster assembly WL1483_74 ENOG4108J1Q WL1483_741 ENOG4105K6T rare lipoprotein A WL1483_742 ENOG4105EYA deoxyribonuclease WL1483_745 ENOG4105FZW flagellar biosynthesis regulator FlhF WL1483_748 ENOG41090ED Protein with unknown function (DUF469) WL1483_75 ENOG4105BZU Histidine kinase WL1483_752 ENOG4105C7N Xanthine uracil vitamin C permease WL1483_753 ENOG4105E18 UPF0276 protein WL1483_756 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) WL1483_757 ENOG4105K63 Thioredoxin WL1483_758 ENOG4108JUB Transcriptional regulator WL1483_762 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WL1483_763 ENOG4105CWM branched-chain amino acid transport system II carrier protein WL1483_764 ENOG4105BZU Histidine kinase WL1483_768 ENOG4105EM2 membrane WL1483_77 ENOG4107QHF type ii secretion system protein e WL1483_770 ENOG4105BZU Histidine kinase WL1483_772 ENOG41062QD Membrane WL1483_774 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain WL1483_775 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) WL1483_777 ENOG4105E39 Enoyl-CoA hydratase WL1483_78 ENOG4105C32 Amino acid ABC transporter (Permease) WL1483_783 ENOG4107QK7 reductase WL1483_787 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WL1483_788 ENOG41063SB peptidase WL1483_79 ENOG4108UVJ appr-1-p processing domain protein WL1483_790 ENOG4105KUZ arsenate reductase WL1483_793 ENOG4105C7K acetolactate synthase WL1483_795 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) WL1483_8 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) WL1483_80 ENOG4105QZU Inner membrane protein YfeZ WL1483_803 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WL1483_807 ENOG4105CEP NADH dehydrogenase WL1483_808 ENOG4107B7Y DNA-binding transcriptional regulator FruR WL1483_809 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WL1483_81 ENOG4108VAU general secretion pathway protein G WL1483_811 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) WL1483_812 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WL1483_814 ENOG4105ECQ AraC Family Transcriptional Regulator WL1483_817 ENOG4105DJ0 Poly(A) Polymerase WL1483_819 ENOG4105DZ1 carboxypeptidase WL1483_821 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WL1483_822 ENOG4105C8Q Methyl-accepting chemotaxis WL1483_824 ENOG4108J1Q WL1483_825 ENOG4105ERU peptidase WL1483_826 ENOG4105D19 Role in flagellar biosynthesis (By similarity) WL1483_83 ENOG4105RD7 BadF BadG BcrA BcrD WL1483_830 ENOG4105CFG Acts as a chaperone (By similarity) WL1483_831 ENOG4107TT5 NLP P60 protein WL1483_833 ENOG4108J1Q WL1483_834 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WL1483_835 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WL1483_836 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) WL1483_837 ENOG4108Z6B deaminase WL1483_841 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WL1483_843 ENOG4105K64 Glycosyl transferase, family 2 WL1483_844 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) WL1483_845 ENOG41067MG lrgb family WL1483_846 ENOG4107MKT Stringent starvation protein a WL1483_847 ENOG4108R6G acetyltransferase WL1483_849 ENOG4105BZU Histidine kinase WL1483_850 ENOG4105MYN Zinc uptake regulation protein WL1483_851 ENOG4105EB3 Histidine kinase WL1483_855 ENOG4105QTB Flavodoxin WL1483_856 ENOG4108IEH NADH dehydrogenase subunit g WL1483_857 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase WL1483_858 ENOG4105XZD Fe-S protein WL1483_859 ENOG4108J1Q WL1483_860 ENOG4105C2J ABC transporter WL1483_861 ENOG4105C2W permease WL1483_864 ENOG4105D8G Major Facilitator superfamily WL1483_865 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) WL1483_867 ENOG4105EXG Transcriptional regulator WL1483_868 ENOG4105CUX Signal transduction histidine kinase WL1483_870 ENOG4108XM1 transcriptional regulator AsnC family WL1483_872 ENOG4105D38 putrescine abc transporter WL1483_874 ENOG4108Z0R Transferase WL1483_875 ENOG4105D2S major facilitator superfamily WL1483_876 ENOG4107RZC phospholipase d WL1483_877 ENOG4105W1T Glycosyl Transferase WL1483_879 ENOG4105CGH 5'-nucleotidase WL1483_88 ENOG4105DHJ ABC, transporter WL1483_880 ENOG4108RIR Molybdenum cofactor biosynthesis protein WL1483_881 ENOG4105CCU oxidase (Subunit III) WL1483_883 ENOG4105E55 glycerol-3-phosphate acyltransferase WL1483_886 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WL1483_888 ENOG4105C6N Formate acetyltransferase WL1483_890 ENOG4106IKR WL1483_891 ENOG4105CXT aspartate transcarbamylase WL1483_892 ENOG4108RH0 Crea protein WL1483_895 ENOG4107QP3 malate synthase g WL1483_896 ENOG4107QHF type ii secretion system protein e WL1483_897 ENOG41090EK ompa motb domain protein WL1483_899 ENOG4105CFQ glutamine synthetase WL1483_90 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WL1483_902 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) WL1483_903 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WL1483_904 ENOG4105CKD glutathione-regulated potassium-efflux system protein WL1483_906 ENOG4107QPN acyl-Coa dehydrogenase WL1483_908 ENOG4105FR1 rard protein WL1483_909 ENOG41073TP transcriptional regulator WL1483_910 ENOG4106032 Glutathionylspermidine synthase WL1483_911 ENOG4108JQB penicillin-binding protein 1C WL1483_912 ENOG4105C9B Cysteine desulfurase WL1483_913 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WL1483_915 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WL1483_917 ENOG4105D7Q type ii secretion system WL1483_92 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN WL1483_922 ENOG4105CEY Amp-dependent synthetase and ligase WL1483_923 ENOG4105F38 ABC transporter, permease WL1483_925 ENOG4105M4P Tetr family transcriptional regulator WL1483_926 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WL1483_927 ENOG4105C03 ribonuclease WL1483_929 ENOG4108UHU Aldolase WL1483_931 ENOG4105C79 DNA protecting protein DprA WL1483_932 ENOG4105GPY SprT protein WL1483_933 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WL1483_934 ENOG4105EG2 ABC transporter, permease WL1483_936 ENOG4105VEQ Cold shock protein WL1483_938 ENOG4105D78 K07001 NTE family protein WL1483_940 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WL1483_942 ENOG4105BZU Histidine kinase WL1483_943 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase WL1483_944 ENOG4105CMV Succinyl-CoA synthetase subunit beta WL1483_951 ENOG4108Z66 YbaK ebsC protein WL1483_957 ENOG41060WC Enoyl-CoA hydratase WL1483_958 ENOG4105YCT UPF0386 protein WL1483_959 ENOG4105D7T ABC transporter WL1483_96 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WL1483_960 ENOG4105CFP Peptidase U32 WL1483_963 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WL1483_965 ENOG4105CSR polyphosphate kinase 2 WL1483_967 ENOG4105C44 Serine transporter WL1483_968 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WL1483_970 ENOG4105CD5 CoA-binding domain protein WL1483_972 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) WL1483_973 ENOG4108SV3 Tmao reductase system periplasmic protein tort WL1483_974 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) WL1483_976 ENOG4108VZM 50s ribosomal protein L10 WL1483_977 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) WL1483_978 ENOG4105BZU Histidine kinase WL1483_979 ENOG41067QW Transcriptional regulator WL1483_981 ENOG4105CUT histidyl-tRNA synthetase WL1483_987 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) WL1483_989 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) WL1483_990 ENOG4105CEN a g-specific adenine glycosylase WL1483_991 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WL1483_992 ENOG4105DY8 decarboxylase WL1483_993 ENOG4108DMF Cytochrome C biogenesis protein WL1483_995 ENOG4105EMY transcriptional regulator WL1483_997 ENOG4105C5Y PTS System