locus-tag	class	description
E5E96_00015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5E96_00035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_00040	COG1309	transcriptional regulator
E5E96_00060	COG1946	Acyl-CoA thioesterase
E5E96_00070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5E96_00080	COG0009	L-threonylcarbamoyladenylate synthase
E5E96_00090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5E96_00095	COG0512	Glutamine amidotransferase of anthranilate synthase
E5E96_00095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_00100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_00105	COG0135	phosphoribosylanthranilate isomerase activity
E5E96_00105	COG0134	indole-3-glycerol-phosphate synthase activity
E5E96_00110	COG0133	tryptophan synthase activity
E5E96_00115	COG0159	tryptophan synthase activity
E5E96_00140	COG1988	membrane-bound metal-dependent
E5E96_00160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_00175	COG3152	Membrane
E5E96_00190	COG2814	Major facilitator Superfamily
E5E96_00195	COG0109	protoheme IX farnesyltransferase activity
E5E96_00200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5E96_00205	COG1845	cytochrome c oxidase, subunit III
E5E96_00210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5E96_00215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5E96_00275	COG0708	Exodeoxyribonuclease III
E5E96_00295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_00300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_00320	COG0095	Lipoate-protein ligase
E5E96_00350	COG0640	Transcriptional regulator
E5E96_00365	COG1285	pathogenesis
E5E96_00370	COG0484	heat shock protein binding
E5E96_00375	COG0443	Heat shock 70 kDa protein
E5E96_00380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5E96_00385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5E96_00395	COG1227	inorganic diphosphatase activity
E5E96_00405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_00410	COG0577	efflux transmembrane transporter activity
E5E96_00410	COG1136	(ABC) transporter
E5E96_00420	COG2375	cellular response to nickel ion
E5E96_00425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_00445	COG3152	Membrane
E5E96_00460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_00465	COG1396	sequence-specific DNA binding
E5E96_00465	COG1917	Cupin 2, conserved barrel domain protein
E5E96_00480	COG0531	amino acid
E5E96_00485	COG0531	amino acid
E5E96_00495	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5E96_00505	COG3384	dioxygenase
E5E96_00510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_00510	COG2205	protein histidine kinase activity
E5E96_00525	COG0813	purine-nucleoside phosphorylase activity
E5E96_00570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E96_00575	COG0083	homoserine kinase activity
E5E96_00590	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E5E96_00595	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E5E96_00610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E96_00620	COG0745	RESPONSE REGULATOR receiver
E5E96_00635	COG4988	ABC transporter
E5E96_00640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5E96_00660	COG1720	tRNA m6t6A37 methyltransferase activity
E5E96_00675	COG0542	response to heat
E5E96_00680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5E96_00685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_00695	COG2190	(PTS) system
E5E96_00710	COG3038	cytochrome b561
E5E96_00725	COG0419	ATPase involved in DNA repair
E5E96_00730	COG0420	3'-5' exonuclease activity
E5E96_00740	COG2974	May be involved in recombination
E5E96_00750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E96_00750	COG4651	solute:proton antiporter activity
E5E96_00765	COG0469	pyruvate kinase activity
E5E96_00770	COG1196	nuclear chromosome segregation
E5E96_00770	COG3264	Mechanosensitive ion channel
E5E96_00780	COG2706	6-phosphogluconolactonase activity
E5E96_00790	COG0281	malic enzyme
E5E96_00805	COG0437	4 iron, 4 sulfur cluster binding
E5E96_00810	COG3383	formate dehydrogenase (NAD+) activity
E5E96_00810	COG3383	formate dehydrogenase (NAD+) activity
E5E96_00840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_00850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E96_00855	COG1910	domain protein
E5E96_00860	COG3852	Histidine kinase
E5E96_00865	COG2204	response regulator
E5E96_00875	COG4662	Binding-protein-dependent transport system inner membrane component
E5E96_00885	COG0746	molybdenum cofactor guanylyltransferase activity
E5E96_00890	COG0303	'Molybdopterin
E5E96_00895	COG1289	transmembrane transporter activity
E5E96_00925	COG3220	belongs to the UPF0276 family
E5E96_00955	COG2205	protein histidine kinase activity
E5E96_00955	COG0784	Response regulator, receiver
E5E96_00960	COG4166	transmembrane transport
E5E96_00965	COG0601	transmembrane transport
E5E96_00970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_00975	COG0444	Belongs to the ABC transporter superfamily
E5E96_00980	COG4608	Belongs to the ABC transporter superfamily
E5E96_00990	COG2971	BadF BadG BcrA BcrD
E5E96_01000	COG0840	transmembrane signaling receptor activity
E5E96_01020	COG3724	N-succinylarginine dihydrolase activity
E5E96_01025	COG0616	signal peptide processing
E5E96_01030	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_01035	COG0583	DNA-binding transcription factor activity
E5E96_01045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E96_01055	COG0583	DNA-binding transcription factor activity
E5E96_01065	COG1881	PFAM PEBP family protein
E5E96_01075	COG3408	Glycogen debranching enzyme
E5E96_01075	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E5E96_01080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E96_01085	COG0739	heme binding
E5E96_01090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5E96_01115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5E96_01125	COG3091	SprT-like family
E5E96_01135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5E96_01140	COG0189	ligase activity
E5E96_01150	COG1678	Uncharacterized ACR, COG1678
E5E96_01155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5E96_01160	COG3104	oligopeptide transport
E5E96_01170	COG0714	Associated with various cellular activities
E5E96_01185	COG1115	amino acid carrier protein
E5E96_01190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E96_01205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5E96_01215	COG1301	dicarboxylic acid transport
E5E96_01225	COG2912	Transglutaminase-like superfamily
E5E96_01235	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E96_01240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5E96_01245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5E96_01250	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5E96_01255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5E96_01265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5E96_01270	COG0737	Belongs to the 5'-nucleotidase family
E5E96_01275	COG0193	aminoacyl-tRNA hydrolase activity
E5E96_01280	COG0012	GTP binding
E5E96_01325	COG0471	metal ion transport
E5E96_01325	COG0490	domain, Protein
E5E96_01355	COG2214	Heat shock protein DnaJ domain protein
E5E96_01370	COG0366	Alpha amylase catalytic
E5E96_01380	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5E96_01380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5E96_01380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_01380	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5E96_01390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_01400	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5E96_01425	COG0180	Tryptophanyl-tRNA synthetase
E5E96_01435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5E96_01445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E5E96_01455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5E96_01460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5E96_01495	COG0583	DNA-binding transcription factor activity
E5E96_01515	COG0583	DNA-binding transcription factor activity
E5E96_01530	COG0739	heme binding
E5E96_01545	COG0584	glycerophosphoryl diester phosphodiesterase
E5E96_01555	COG1053	succinate dehydrogenase
E5E96_01560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5E96_01565	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E5E96_01590	COG3214	Protein conserved in bacteria
E5E96_01625	COG0745	RESPONSE REGULATOR receiver
E5E96_01630	COG0642	Histidine kinase
E5E96_01650	COG0516	GMP reductase activity
E5E96_01660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5E96_01665	COG3647	Membrane
E5E96_01675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E96_01685	COG3706	GGDEF domain
E5E96_01695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_01705	COG0583	DNA-binding transcription factor activity
E5E96_01710	COG3706	GGDEF domain
E5E96_01720	COG1335	isochorismatase
E5E96_01725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_01730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E96_01735	COG1702	phosphate starvation-inducible protein PhoH
E5E96_01740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5E96_01745	COG4535	Mg2 and Co2 transporter CorC
E5E96_01750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5E96_01755	COG2888	peptidyl-tyrosine sulfation
E5E96_01760	COG0495	leucyl-tRNA aminoacylation
E5E96_01775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5E96_01780	COG0799	negative regulation of ribosome biogenesis
E5E96_01785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5E96_01790	COG0768	penicillin binding
E5E96_01795	COG0772	Belongs to the SEDS family
E5E96_01800	COG0772	Belongs to the SEDS family
E5E96_01805	COG2951	lytic endotransglycosylase activity
E5E96_01810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5E96_01815	COG1686	Belongs to the peptidase S11 family
E5E96_01820	COG2921	Belongs to the UPF0250 family
E5E96_01825	COG0321	lipoyl(octanoyl) transferase activity
E5E96_01835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5E96_01845	COG3545	Serine hydrolase
E5E96_01850	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_01865	COG0789	Transcriptional regulator
E5E96_01875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_01880	COG1970	mechanosensitive ion channel activity
E5E96_01885	COG3706	GGDEF domain
E5E96_01890	COG4974	Belongs to the 'phage' integrase family
E5E96_01900	COG0312	modulator of DNA gyrase
E5E96_01905	COG0312	modulator of DNA gyrase
E5E96_01970	COG3275	phosphorelay sensor kinase activity
E5E96_01975	COG3279	Response regulator of the LytR AlgR family
E5E96_01980	COG1966	Carbon starvation protein
E5E96_01990	COG0114	fumarate hydratase activity
E5E96_02000	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5E96_02010	COG2211	Major facilitator Superfamily
E5E96_02015	COG1185	polyribonucleotide nucleotidyltransferase activity
E5E96_02020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5E96_02025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5E96_02030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5E96_02035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5E96_02040	COG0195	Participates in both transcription termination and antitermination
E5E96_02045	COG0779	Required for maturation of 30S ribosomal subunits
E5E96_02060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5E96_02065	COG0149	triose-phosphate isomerase activity
E5E96_02070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5E96_02075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5E96_02085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5E96_02090	COG1534	Rna-binding protein
E5E96_02105	COG1360	Flagellar Motor Protein
E5E96_02110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_02115	COG1722	exodeoxyribonuclease VII activity
E5E96_02120	COG0142	geranyltranstransferase activity
E5E96_02125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5E96_02145	COG4172	Belongs to the ABC transporter superfamily
E5E96_02150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5E96_02155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5E96_02160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_02165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5E96_02185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E96_02185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E96_02190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5E96_02200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5E96_02210	COG3381	protein complex oligomerization
E5E96_02230	COG3300	MHYT domain
E5E96_02230	COG5001	Diguanylate cyclase
E5E96_02240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E96_02245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5E96_02250	COG0511	ligase activity, forming carbon-carbon bonds
E5E96_02255	COG0439	Biotin carboxylase
E5E96_02265	COG4145	pantothenate transmembrane transporter activity
E5E96_02270	COG1263	PTS System
E5E96_02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_02270	COG2190	(PTS) system
E5E96_02275	COG0583	DNA-binding transcription factor activity
E5E96_02280	COG0604	alcohol dehydrogenase
E5E96_02285	COG2264	protein methyltransferase activity
E5E96_02300	COG0778	Nitroreductase
E5E96_02310	COG0616	signal peptide processing
E5E96_02330	COG3139	Protein of unknown function (DUF1315)
E5E96_02335	COG0252	asparaginase activity
E5E96_02340	COG0786	glutamate:sodium symporter activity
E5E96_02355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5E96_02360	COG0384	phenazine biosynthesis protein PhzF
E5E96_02365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E96_02370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E96_02375	COG0175	sulfate reduction
E5E96_02380	COG2113	Glycine betaine
E5E96_02385	COG4176	ABC-type proline glycine betaine transport system permease component
E5E96_02390	COG4175	Glycine betaine
E5E96_02400	COG3610	response to peptide
E5E96_02405	COG2966	Psort location CytoplasmicMembrane, score
E5E96_02415	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E96_02425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_02430	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_02440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_02475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_02490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E96_02530	COG1858	cytochrome C peroxidase
E5E96_02540	COG2313	pseudouridylate synthase activity
E5E96_02545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_02580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5E96_02600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5E96_02610	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E96_02620	COG4608	Belongs to the ABC transporter superfamily
E5E96_02625	COG0444	Belongs to the ABC transporter superfamily
E5E96_02635	COG4239	(ABC) transporter, permease
E5E96_02640	COG4174	ABC transporter (Permease)
E5E96_02655	COG0811	peptide transport
E5E96_02660	COG0811	peptide transport
E5E96_02665	COG0848	biopolymer transport protein
E5E96_02715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_02720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_02725	COG0840	transmembrane signaling receptor activity
E5E96_02735	COG1278	Cold shock
E5E96_02775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5E96_02780	COG1162	GTPase activity
E5E96_02785	COG0688	phosphatidylethanolamine metabolic process
E5E96_02790	COG4628	conserved protein (DUF2132)
E5E96_02805	COG3059	membrane
E5E96_02810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E96_02825	COG3300	MHYT domain
E5E96_02825	COG5001	Diguanylate cyclase
E5E96_02830	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E5E96_02865	COG1132	(ABC) transporter
E5E96_02875	COG1404	Belongs to the peptidase S8 family
E5E96_02880	COG2897	thiosulfate sulfurtransferase activity
E5E96_02885	COG2066	Belongs to the glutaminase family
E5E96_02890	COG3171	Protein conserved in bacteria
E5E96_02895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5E96_02900	COG2234	aminopeptidase activity
E5E96_02900	COG4935	Belongs to the peptidase S8 family
E5E96_02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_02910	COG2200	EAL domain
E5E96_02915	COG1090	epimerase
E5E96_02920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5E96_02925	COG4181	ATPase activity
E5E96_02930	COG2755	lipolytic protein G-D-S-L family
E5E96_02935	COG0784	Response regulator, receiver
E5E96_02935	COG0835	chemotaxis
E5E96_02945	COG0569	domain protein
E5E96_02945	COG2985	domain, Protein
E5E96_02950	COG1272	protein, Hemolysin III
E5E96_02955	COG0076	glutamate decarboxylase activity
E5E96_02960	COG2917	probably involved in intracellular septation
E5E96_02965	COG2350	Protein conserved in bacteria
E5E96_02975	COG1555	photosystem II stabilization
E5E96_02980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5E96_02985	COG3104	oligopeptide transport
E5E96_02990	COG0745	RESPONSE REGULATOR receiver
E5E96_03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_03040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5E96_03045	COG1280	lysine exporter protein (LysE YggA)
E5E96_03070	COG0316	Belongs to the HesB IscA family
E5E96_03080	COG0038	chloride channel
E5E96_03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5E96_03100	COG0671	phosphoesterase, PA-phosphatase related
E5E96_03110	COG0784	Response regulator, receiver
E5E96_03110	COG3437	response regulator, receiver
E5E96_03120	COG2076	Multidrug Resistance protein
E5E96_03130	COG0346	lactoylglutathione lyase activity
E5E96_03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_03140	COG1643	Atp-dependent helicase
E5E96_03150	COG1489	DNA binding
E5E96_03155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5E96_03160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_03175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5E96_03180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5E96_03200	COG1924	4 iron, 4 sulfur cluster binding
E5E96_03205	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E5E96_03210	COG0842	Transport permease protein
E5E96_03215	COG1131	(ABC) transporter
E5E96_03230	COG0163	prenyltransferase activity
E5E96_03235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E96_03240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5E96_03260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E5E96_03275	COG1136	(ABC) transporter
E5E96_03295	COG0840	transmembrane signaling receptor activity
E5E96_03320	COG0529	Catalyzes the synthesis of activated sulfate
E5E96_03325	COG3273	potassium ion transport
E5E96_03325	COG0471	metal ion transport
E5E96_03330	COG2895	sulfate adenylyltransferase (ATP) activity
E5E96_03335	COG0175	sulfate reduction
E5E96_03340	COG1648	precorrin-2 dehydrogenase activity
E5E96_03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E96_03345	COG0330	HflC and HflK could
E5E96_03350	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5E96_03355	COG0517	IMP dehydrogenase activity
E5E96_03355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E96_03360	COG0488	(ABC) transporter
E5E96_03370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5E96_03375	COG0583	DNA-binding transcription factor activity
E5E96_03410	COG0789	Transcriptional regulator
E5E96_03415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E96_03425	COG0668	transmembrane transport
E5E96_03435	COG2731	YhcH YjgK YiaL family protein
E5E96_03450	COG1794	racemase activity, acting on amino acids and derivatives
E5E96_03460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_03485	COG0733	neurotransmitter:sodium symporter activity
E5E96_03495	COG0733	neurotransmitter:sodium symporter activity
E5E96_03510	COG0561	phosphatase activity
E5E96_03540	COG1846	Transcriptional regulator
E5E96_03545	COG1764	response to oxidative stress
E5E96_03550	COG2130	NADP-dependent
E5E96_03555	COG1051	belongs to the nudix hydrolase family
E5E96_03575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5E96_03580	COG1640	4-alpha-glucanotransferase
E5E96_03585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E96_03590	COG0676	glucose-6-phosphate 1-epimerase activity
E5E96_03595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5E96_03600	COG0840	transmembrane signaling receptor activity
E5E96_03675	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E5E96_03680	COG2885	chlorophyll binding
E5E96_03685	COG0823	Involved in the tonB-independent uptake of proteins
E5E96_03700	COG0811	peptide transport
E5E96_03705	COG0824	Thioesterase
E5E96_03710	COG3790	cyd operon protein YbgE
E5E96_03715	COG4890	Cyd operon protein YbgT
E5E96_03720	COG1294	oxidase, subunit
E5E96_03725	COG1271	oxidase subunit
E5E96_03730	COG2255	four-way junction helicase activity
E5E96_03735	COG0632	four-way junction helicase activity
E5E96_03740	COG0840	transmembrane signaling receptor activity
E5E96_03745	COG0442	prolyl-tRNA aminoacylation
E5E96_03750	COG4221	oxidoreductase activity
E5E96_03765	COG1024	Enoyl-CoA hydratase
E5E96_03785	COG4166	transmembrane transport
E5E96_03800	COG1872	DUF167
E5E96_03805	COG0762	integral membrane protein
E5E96_03810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5E96_03815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5E96_03830	COG3022	response to hydroperoxide
E5E96_03835	COG0513	Belongs to the DEAD box helicase family
E5E96_03840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5E96_03865	COG0735	belongs to the Fur family
E5E96_03870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E96_03885	COG0776	regulation of translation
E5E96_03895	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E5E96_03920	COG0560	Phosphoserine phosphatase
E5E96_03930	COG5002	protein histidine kinase activity
E5E96_03930	COG5001	Diguanylate cyclase
E5E96_03930	COG3447	MASE1 domain protein
E5E96_03935	COG0813	purine-nucleoside phosphorylase activity
E5E96_03940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5E96_03945	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5E96_03950	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E96_03960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_03965	COG0084	hydrolase, TatD family'
E5E96_03980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_03985	COG0004	ammonium transporteR
E5E96_04000	COG0795	lipopolysaccharide-transporting ATPase activity
E5E96_04005	COG0795	lipopolysaccharide-transporting ATPase activity
E5E96_04010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E96_04015	COG2927	DNA polymerase III (CHI subunit)
E5E96_04020	COG0525	valine-tRNA ligase activity
E5E96_04025	COG1253	flavin adenine dinucleotide binding
E5E96_04030	COG0586	Pfam SNARE associated Golgi protein
E5E96_04035	COG1686	Belongs to the peptidase S11 family
E5E96_04070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E5E96_04075	COG0527	aspartate kinase activity
E5E96_04080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5E96_04090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5E96_04095	COG1546	Belongs to the CinA family
E5E96_04100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5E96_04120	COG3068	Protein conserved in bacteria
E5E96_04130	COG0739	heme binding
E5E96_04150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E5E96_04155	COG1121	(ABC) transporter
E5E96_04160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5E96_04165	COG0583	DNA-binding transcription factor activity
E5E96_04170	COG0697	spore germination
E5E96_04175	COG1573	uracil-dna glycosylase
E5E96_04180	COG2962	Rard protein
E5E96_04190	COG2827	Endonuclease containing a URI domain
E5E96_04205	COG1842	Phage shock protein A
E5E96_04210	COG0204	Acyl-transferase
E5E96_04230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_04275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5E96_04290	COG1289	transmembrane transporter activity
E5E96_04295	COG1566	PFAM secretion protein HlyD family protein
E5E96_04310	COG1051	belongs to the nudix hydrolase family
E5E96_04315	COG3150	esterase
E5E96_04325	COG3151	Protein conserved in bacteria
E5E96_04330	COG0494	nUDIX hydrolase
E5E96_04335	COG1538	Outer membrane efflux protein
E5E96_04340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5E96_04340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5E96_04345	COG1560	Kdo2-lipid A biosynthetic process
E5E96_04360	COG1392	Phosphate transport regulator
E5E96_04365	COG0306	phosphate transporter
E5E96_04370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5E96_04400	COG0583	DNA-binding transcription factor activity
E5E96_04405	COG1380	Effector of murein hydrolase LrgA
E5E96_04410	COG1346	cytolysis
E5E96_04425	COG0617	tRNA 3'-terminal CCA addition
E5E96_04430	COG3267	Type II secretory pathway component ExeA
E5E96_04430	COG3409	Peptidoglycan-binding domain 1 protein
E5E96_04440	COG1194	a g-specific adenine glycosylase
E5E96_04445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E5E96_04455	COG3111	PFAM Bacterial OB fold (BOF) protein
E5E96_04460	COG3240	lipase activity
E5E96_04470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E5E96_04470	COG2885	chlorophyll binding
E5E96_04475	COG3009	Protein conserved in bacteria
E5E96_04480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E96_04480	COG3008	intermembrane lipid transfer
E5E96_04485	COG2995	paraquat-inducible protein a
E5E96_04495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_04505	COG2203	Gaf domain
E5E96_04505	COG3706	GGDEF domain
E5E96_04505	COG4251	negative regulation of phosphorylation
E5E96_04505	COG5001	Diguanylate cyclase
E5E96_04510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5E96_04515	COG2813	Specifically methylates the guanine in position
E5E96_04520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_04525	COG0297	glycogen (starch) synthase activity
E5E96_04565	COG1757	Na H antiporter
E5E96_04570	COG0583	DNA-binding transcription factor activity
E5E96_04575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5E96_04580	COG3842	ATPase activity
E5E96_04585	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E96_04590	COG1177	transmembrane transport
E5E96_04595	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_04605	COG5006	permease, DMT superfamily
E5E96_04610	COG1522	sequence-specific DNA binding
E5E96_04615	COG0110	maltose O-acetyltransferase activity
E5E96_04620	COG0366	Alpha amylase catalytic
E5E96_04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_04625	COG1263	PTS System
E5E96_04660	COG1803	Methylglyoxal synthase
E5E96_04685	COG1444	tRNA N-acetyltransferase activity
E5E96_04690	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_04695	COG0835	chemotaxis
E5E96_04695	COG0784	Response regulator, receiver
E5E96_04740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5E96_04745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5E96_04760	COG0477	Major facilitator Superfamily
E5E96_04765	COG0523	cobalamin synthesis protein
E5E96_04775	COG1280	lysine exporter protein (LysE YggA)
E5E96_04785	COG2200	EAL domain
E5E96_04790	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5E96_04795	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5E96_04800	COG0840	transmembrane signaling receptor activity
E5E96_04805	COG0840	transmembrane signaling receptor activity
E5E96_04815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E96_04820	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E96_04825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5E96_04830	COG2186	Transcriptional regulator
E5E96_04860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_04865	COG1459	type II secretion system
E5E96_04880	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E5E96_04885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5E96_04890	COG0494	nUDIX hydrolase
E5E96_04900	COG0653	protein targeting
E5E96_04910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E5E96_04915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5E96_04920	COG0849	cell division
E5E96_04925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5E96_04930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E96_04935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5E96_04940	COG0772	Belongs to the SEDS family
E5E96_04945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5E96_04950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5E96_04955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5E96_04965	COG0768	penicillin binding
E5E96_04970	COG3116	cell division
E5E96_04975	COG0275	rRNA processing
E5E96_04980	COG2001	Belongs to the MraZ family
E5E96_04990	COG0741	lytic transglycosylase activity
E5E96_04990	COG1388	LysM domain
E5E96_05000	COG1360	Flagellar Motor Protein
E5E96_05005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_05010	COG1191	sigma factor activity
E5E96_05035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E5E96_05040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_05045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_05065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_05070	COG4786	Flagellar basal body rod
E5E96_05070	COG1256	bacterial-type flagellum assembly
E5E96_05080	COG1706	bacterial-type flagellum-dependent cell motility
E5E96_05085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5E96_05090	COG4786	Flagellar basal body rod
E5E96_05100	COG1749	Flagellar hook protein flgE
E5E96_05115	COG1815	bacterial-type flagellum-dependent cell motility
E5E96_05150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5E96_05160	COG1677	Flagellar hook-basal body complex protein FliE
E5E96_05185	COG1987	bacterial-type flagellum assembly
E5E96_05210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5E96_05215	COG3107	peptidoglycan biosynthetic process
E5E96_05220	COG0792	nuclease activity
E5E96_05225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E96_05230	COG2823	Periplasmic or secreted lipoprotein
E5E96_05235	COG2969	positive regulation of protein catabolic process
E5E96_05240	COG0625	glutathione transferase activity
E5E96_05245	COG2857	Cytochrome c1
E5E96_05250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5E96_05255	COG0723	plastoquinol--plastocyanin reductase activity
E5E96_05260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5E96_05265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5E96_05270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5E96_05280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E96_05285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E96_05315	COG3964	amidohydrolase
E5E96_05330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_05330	COG3711	transcriptional antiterminator
E5E96_05335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_05340	COG1660	Displays ATPase and GTPase activities
E5E96_05345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_05355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5E96_05360	COG1137	ATPase activity
E5E96_05365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5E96_05370	COG3117	lipopolysaccharide transmembrane transporter activity
E5E96_05375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5E96_05380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E96_05380	COG0517	IMP dehydrogenase activity
E5E96_05385	COG1127	ABC transporter
E5E96_05390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5E96_05395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E96_05400	COG2854	intermembrane phospholipid transfer
E5E96_05410	COG5007	Belongs to the BolA IbaG family
E5E96_05415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5E96_05420	COG0312	modulator of DNA gyrase
E5E96_05425	COG3028	Belongs to the UPF0307 family
E5E96_05435	COG2926	Belongs to the UPF0265 family
E5E96_05465	COG1396	sequence-specific DNA binding
E5E96_05470	COG3135	benzoate transporter
E5E96_05495	COG0840	transmembrane signaling receptor activity
E5E96_05505	COG3706	GGDEF domain
E5E96_05510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5E96_05515	COG2197	response regulator
E5E96_05520	COG0629	single-stranded DNA binding
E5E96_05560	COG5642	Protein of unknown function (DUF2384)
E5E96_05565	COG5499	transcription regulator containing HTH domain
E5E96_05595	COG1278	Cold shock
E5E96_05600	COG4771	TonB-dependent receptor
E5E96_05605	COG5001	Diguanylate cyclase
E5E96_05605	COG2203	Gaf domain
E5E96_05605	COG3706	GGDEF domain
E5E96_05605	COG4251	negative regulation of phosphorylation
E5E96_05615	COG0745	RESPONSE REGULATOR receiver
E5E96_05650	COG0346	lactoylglutathione lyase activity
E5E96_05665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5E96_05670	COG1074	ATP-dependent DNA helicase activity
E5E96_05675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5E96_05680	COG2259	Doxx family
E5E96_05685	COG1741	Belongs to the pirin family
E5E96_05695	COG0583	DNA-binding transcription factor activity
E5E96_05720	COG1175	transmembrane transport
E5E96_05730	COG3842	ATPase activity
E5E96_05740	COG2199	diguanylate cyclase activity
E5E96_05740	COG2203	Gaf domain
E5E96_05760	COG1247	-acetyltransferase
E5E96_05765	COG0753	catalase activity
E5E96_05790	COG0494	nUDIX hydrolase
E5E96_05795	COG0628	permease
E5E96_05800	COG4221	oxidoreductase activity
E5E96_05805	COG2957	Belongs to the agmatine deiminase family
E5E96_05815	COG3284	Transcriptional regulator
E5E96_05830	COG1461	Dihydroxyacetone kinase
E5E96_05835	COG2376	Dihydroxyacetone kinase
E5E96_05840	COG2252	PERMEase
E5E96_05880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E96_05885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E96_05890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5E96_05895	COG0049	tRNA binding
E5E96_05900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5E96_05905	COG2168	tRNA wobble position uridine thiolation
E5E96_05910	COG2923	Belongs to the DsrF TusC family
E5E96_05920	COG0251	oxidation-reduction process
E5E96_05925	COG2964	Protein conserved in bacteria
E5E96_05930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5E96_05935	COG0085	RNA polymerase activity
E5E96_05940	COG0222	ribosome binding
E5E96_05945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5E96_05950	COG0081	regulation of translation
E5E96_05955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5E96_05960	COG0250	Participates in transcription elongation, termination and antitermination
E5E96_05975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E96_06000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5E96_06005	COG0569	domain protein
E5E96_06010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_06030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5E96_06035	COG3005	denitrification pathway
E5E96_06040	COG0243	molybdopterin cofactor binding
E5E96_06050	COG2205	protein histidine kinase activity
E5E96_06070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5E96_06090	COG2204	response regulator
E5E96_06100	COG2205	protein histidine kinase activity
E5E96_06125	COG5413	integral membrane protein
E5E96_06135	COG1522	sequence-specific DNA binding
E5E96_06140	COG2502	aspartate--ammonia ligase
E5E96_06150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5E96_06155	COG0542	response to heat
E5E96_06165	COG0564	pseudouridine synthase activity
E5E96_06170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_06185	COG3681	Belongs to the UPF0597 family
E5E96_06195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5E96_06200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5E96_06205	COG1979	alcohol dehydrogenase
E5E96_06210	COG2207	Transcriptional regulator
E5E96_06215	COG3040	lipid binding
E5E96_06225	COG0688	phosphatidylethanolamine metabolic process
E5E96_06245	COG0540	Belongs to the ATCase OTCase family
E5E96_06250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E5E96_06255	COG1438	arginine binding
E5E96_06260	COG1288	antiporter activity
E5E96_06265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E96_06295	COG0840	transmembrane signaling receptor activity
E5E96_06315	COG3250	beta-galactosidase activity
E5E96_06320	COG1609	Transcriptional regulator
E5E96_06325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E96_06335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5E96_06340	COG2017	converts alpha-aldose to the beta-anomer
E5E96_06345	COG0667	Aldo Keto reductase
E5E96_06350	COG1968	undecaprenyl-diphosphatase activity
E5E96_06355	COG3806	Anti-sigma factor
E5E96_06360	COG1595	DNA-templated transcription, initiation
E5E96_06380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5E96_06385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5E96_06390	COG0477	Major facilitator Superfamily
E5E96_06400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E96_06410	COG2116	formate transmembrane transporter activity
E5E96_06415	COG1648	precorrin-2 dehydrogenase activity
E5E96_06415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E96_06420	COG2239	Acts as a magnesium transporter
E5E96_06430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E96_06435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5E96_06445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5E96_06455	COG0514	ATP-dependent DNA helicase (RecQ)
E5E96_06460	COG2050	protein possibly involved in aromatic compounds catabolism
E5E96_06475	COG2258	MOSC domain
E5E96_06480	COG1177	transmembrane transport
E5E96_06485	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E96_06490	COG3842	ATPase activity
E5E96_06510	COG0174	glutamine synthetase
E5E96_06530	COG3045	CreA protein
E5E96_06535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E96_06540	COG0443	Heat shock 70 kDa protein
E5E96_06555	COG0366	Alpha amylase catalytic
E5E96_06560	COG1086	Polysaccharide biosynthesis protein
E5E96_06565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E96_06570	COG4750	Nucleotidyl transferase
E5E96_06575	COG0512	Glutamine amidotransferase of anthranilate synthase
E5E96_06575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_06590	COG0529	Catalyzes the synthesis of activated sulfate
E5E96_06610	COG0438	transferase activity, transferring glycosyl groups
E5E96_06625	COG1215	transferase activity, transferring glycosyl groups
E5E96_06640	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_06645	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_06660	COG1083	cytidylyl-transferase
E5E96_06670	COG2089	acid synthase
E5E96_06690	COG4310	Domain of unknown function (DUF2172)
E5E96_06725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_06730	COG0745	RESPONSE REGULATOR receiver
E5E96_06735	COG2205	protein histidine kinase activity
E5E96_06745	COG0281	malic enzyme
E5E96_06750	COG0702	epimerase
E5E96_06755	COG0254	rRNA binding
E5E96_06760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5E96_06780	COG0129	dihydroxy-acid dehydratase activity
E5E96_06790	COG3978	acetolactate synthase activity
E5E96_06805	COG0606	chelatase, subunit chli
E5E96_06810	COG0204	Acyl-transferase
E5E96_06815	COG0204	Acyl-transferase
E5E96_06820	COG1683	Conserved Protein
E5E96_06830	COG1335	isochorismatase
E5E96_06840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_06845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5E96_06855	COG3084	Protein conserved in bacteria
E5E96_06860	COG4251	negative regulation of phosphorylation
E5E96_06860	COG3706	GGDEF domain
E5E96_06860	COG5001	Diguanylate cyclase
E5E96_06860	COG2203	Gaf domain
E5E96_06865	COG0789	Transcriptional regulator
E5E96_06875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5E96_06880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5E96_06885	COG1561	YicC-like family, N-terminal region
E5E96_06905	COG3306	glycosyltransferase involved in LPS biosynthesis
E5E96_06920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E96_06930	COG0156	8-amino-7-oxononanoate synthase activity
E5E96_06935	COG1063	alcohol dehydrogenase
E5E96_06940	COG3245	cytochrome
E5E96_06950	COG0210	DNA helicase
E5E96_06955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E96_06960	COG2166	iron-sulfur cluster assembly
E5E96_06965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5E96_07005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5E96_07015	COG0583	DNA-binding transcription factor activity
E5E96_07030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5E96_07035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5E96_07040	COG2223	nitrite transmembrane transporter activity
E5E96_07045	COG3279	Response regulator of the LytR AlgR family
E5E96_07050	COG3275	phosphorelay sensor kinase activity
E5E96_07060	COG2205	protein histidine kinase activity
E5E96_07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_07080	COG3188	usher protein
E5E96_07100	COG2223	nitrite transmembrane transporter activity
E5E96_07105	COG2081	HI0933 family
E5E96_07110	COG1528	Iron-storage protein
E5E96_07115	COG3706	GGDEF domain
E5E96_07120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E96_07125	COG0589	response to stress
E5E96_07165	COG3642	lipopolysaccharide core region biosynthetic process
E5E96_07170	COG0859	PFAM glycosyl transferase family 9
E5E96_07180	COG1758	RNA polymerase activity
E5E96_07185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E96_07190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E96_07195	COG2267	carboxylic ester hydrolase activity
E5E96_07200	COG0561	phosphatase activity
E5E96_07230	COG1309	transcriptional regulator
E5E96_07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_07240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_07245	COG4191	Histidine kinase
E5E96_07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E96_07290	COG2205	protein histidine kinase activity
E5E96_07295	COG0745	RESPONSE REGULATOR receiver
E5E96_07300	COG2814	Major facilitator Superfamily
E5E96_07315	COG3977	Valine--pyruvate aminotransferase
E5E96_07320	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E96_07325	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E96_07330	COG2378	regulation of single-species biofilm formation
E5E96_07345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5E96_07350	COG0592	DNA-directed DNA polymerase activity
E5E96_07355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5E96_07380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5E96_07385	COG0594	ribonuclease P activity
E5E96_07390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5E96_07395	COG0706	membrane insertase activity
E5E96_07400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5E96_07420	COG4615	Cyclic peptide transporter
E5E96_07425	COG4774	siderophore transport
E5E96_07430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E96_07435	COG0445	tRNA wobble uridine modification
E5E96_07440	COG0357	Ribosomal RNA small subunit methyltransferase G
E5E96_07445	COG1192	Involved in chromosome partitioning
E5E96_07450	COG1475	DNA binding
E5E96_07460	COG0356	it plays a direct role in the translocation of protons across the membrane
E5E96_07470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5E96_07475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5E96_07480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5E96_07485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5E96_07490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5E96_07495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5E96_07500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5E96_07505	COG4452	Inner membrane protein CreD
E5E96_07520	COG0745	RESPONSE REGULATOR receiver
E5E96_07525	COG1349	DNA-binding transcription factor activity
E5E96_07535	COG2771	luxR family
E5E96_07545	COG0811	peptide transport
E5E96_07550	COG0811	peptide transport
E5E96_07555	COG0848	biopolymer transport protein
E5E96_07560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E5E96_07600	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_07605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5E96_07615	COG3165	ubiquinone biosynthetic process from chorismate
E5E96_07620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5E96_07630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E96_07635	COG0805	protein transport
E5E96_07640	COG0084	hydrolase, TatD family'
E5E96_07660	COG0742	ribosomal rna small subunit methyltransferase
E5E96_07675	COG0248	Ppx GppA phosphatase
E5E96_07680	COG0513	Belongs to the DEAD box helicase family
E5E96_07685	COG3118	belongs to the thioredoxin family
E5E96_07700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5E96_07725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_07765	COG1609	Transcriptional regulator
E5E96_07770	COG3604	Transcriptional regulator
E5E96_07775	COG0426	domain, Protein
E5E96_07775	COG1773	rubredoxin
E5E96_07780	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_07790	COG0348	domain, Protein
E5E96_07795	COG0814	amino acid
E5E96_07830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5E96_07840	COG0751	glycine-tRNA ligase activity
E5E96_07845	COG0752	glycyl-tRNA synthetase alpha subunit
E5E96_07850	COG2818	Glycosylase
E5E96_07860	COG2885	chlorophyll binding
E5E96_07865	COG0251	oxidation-reduction process
E5E96_07870	COG0425	Belongs to the sulfur carrier protein TusA family
E5E96_07885	COG2205	protein histidine kinase activity
E5E96_07890	COG0745	RESPONSE REGULATOR receiver
E5E96_07895	COG0183	Belongs to the thiolase family
E5E96_07900	COG1024	Enoyl-CoA hydratase
E5E96_07900	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E96_07905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E96_07910	COG0006	proline dipeptidase activity
E5E96_07915	COG1739	Uncharacterized protein family UPF0029
E5E96_07920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_07925	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E5E96_07950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_07950	COG1042	CoA-binding domain protein
E5E96_07950	COG0045	succinate-CoA ligase (ADP-forming) activity
E5E96_07965	COG0583	DNA-binding transcription factor activity
E5E96_07970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5E96_07975	COG0166	Belongs to the GPI family
E5E96_07990	COG0668	transmembrane transport
E5E96_07995	COG1309	transcriptional regulator
E5E96_08000	COG0756	dUTP diphosphatase activity
E5E96_08005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5E96_08010	COG2003	Belongs to the UPF0758 family
E5E96_08015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5E96_08020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5E96_08030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5E96_08035	COG2990	Protein conserved in bacteria
E5E96_08040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5E96_08045	COG0859	PFAM glycosyl transferase family 9
E5E96_08050	COG0463	Glycosyl transferase, family 2
E5E96_08055	COG0859	PFAM glycosyl transferase family 9
E5E96_08060	COG1519	Transferase
E5E96_08080	COG1609	Transcriptional regulator
E5E96_08085	COG0604	alcohol dehydrogenase
E5E96_08105	COG1580	Controls the rotational direction of flagella during chemotaxis
E5E96_08110	COG3161	chorismate lyase activity
E5E96_08115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5E96_08120	COG2937	Belongs to the GPAT DAPAT family
E5E96_08125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E96_08150	COG0534	Mate efflux family protein
E5E96_08155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5E96_08160	COG2205	protein histidine kinase activity
E5E96_08165	COG0745	RESPONSE REGULATOR receiver
E5E96_08175	COG1045	serine acetyltransferase
E5E96_08185	COG3074	FtsZ-dependent cytokinesis
E5E96_08190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E5E96_08195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_08195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_08200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5E96_08235	COG1609	Transcriptional regulator
E5E96_08240	COG3250	beta-galactosidase activity
E5E96_08245	COG2731	YhcH YjgK YiaL family protein
E5E96_08250	COG0531	amino acid
E5E96_08255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_08260	COG0531	amino acid
E5E96_08265	COG0385	Bile acid
E5E96_08270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5E96_08290	COG0583	DNA-binding transcription factor activity
E5E96_08315	COG0210	DNA helicase
E5E96_08330	COG1943	Transposase
E5E96_08385	COG1280	lysine exporter protein (LysE YggA)
E5E96_08390	COG2391	methyltransferase activity
E5E96_08395	COG0840	transmembrane signaling receptor activity
E5E96_08405	COG1280	lysine exporter protein (LysE YggA)
E5E96_08415	COG2962	Rard protein
E5E96_08425	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_08430	COG1396	sequence-specific DNA binding
E5E96_08445	COG0519	Catalyzes the synthesis of GMP from XMP
E5E96_08445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E96_08450	COG0686	Belongs to the AlaDH PNT family
E5E96_08455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_08475	COG1322	Protein conserved in bacteria
E5E96_08480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_08485	COG0569	domain protein
E5E96_08490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_08490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_08495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E96_08500	COG0242	peptide deformylase activity
E5E96_08510	COG0758	DNA mediated transformation
E5E96_08515	COG2922	Belongs to the Smg family
E5E96_08520	COG0551	DNA topoisomerase type I activity
E5E96_08530	COG0009	L-threonylcarbamoyladenylate synthase
E5E96_08535	COG0408	coproporphyrinogen oxidase activity
E5E96_08540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5E96_08550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5E96_08565	COG3078	GTPase activator activity
E5E96_08575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E96_08580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5E96_08585	COG2204	response regulator
E5E96_08590	COG3852	Histidine kinase
E5E96_08600	COG0174	glutamine synthetase
E5E96_08610	COG1295	ribonuclease BN
E5E96_08615	COG1490	D-aminoacyl-tRNA deacylase activity
E5E96_08625	COG0456	acetyltransferase
E5E96_08635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5E96_08640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_08645	COG2610	gluconate transmembrane transporter activity
E5E96_08650	COG3265	gluconokinase activity
E5E96_08660	COG0800	Aldolase
E5E96_08665	COG1609	Transcriptional regulator
E5E96_08675	COG4942	peptidase
E5E96_08680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5E96_08685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_08690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5E96_08695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5E96_08700	COG0316	Belongs to the HesB IscA family
E5E96_08700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5E96_08710	COG0596	Alpha beta hydrolase
E5E96_08730	COG2183	response to ionizing radiation
E5E96_08735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E96_08740	COG0745	RESPONSE REGULATOR receiver
E5E96_08755	COG0051	transcription antitermination factor activity, RNA binding
E5E96_08760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5E96_08765	COG0088	Forms part of the polypeptide exit tunnel
E5E96_08770	COG0089	rRNA binding
E5E96_08775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5E96_08780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5E96_08785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5E96_08790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5E96_08795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5E96_08800	COG0255	Belongs to the universal ribosomal protein uL29 family
E5E96_08805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5E96_08810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5E96_08815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5E96_08820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5E96_08825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5E96_08830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5E96_08835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5E96_08840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5E96_08845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5E96_08850	COG1841	ribosomal large subunit assembly
E5E96_08855	COG0200	Binds to the 23S rRNA
E5E96_08860	COG0201	protein transport
E5E96_08865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E96_08870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5E96_08875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5E96_08880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5E96_08885	COG0202	RNA polymerase activity
E5E96_08890	COG0203	ribosomal protein L17
E5E96_08945	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5E96_08950	COG0583	DNA-binding transcription factor activity
E5E96_08955	COG4221	oxidoreductase activity
E5E96_08970	COG1770	oligopeptidase
E5E96_08995	COG3714	YhhN family
E5E96_09020	COG1301	dicarboxylic acid transport
E5E96_09030	COG2095	MarC family integral membrane protein
E5E96_09040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E96_09050	COG0741	lytic transglycosylase activity
E5E96_09055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_09080	COG0742	ribosomal rna small subunit methyltransferase
E5E96_09085	COG0552	protein localization to endoplasmic reticulum
E5E96_09090	COG2884	Cell division ATP-binding protein ftsE
E5E96_09095	COG2177	Part of the ABC transporter FtsEX involved in
E5E96_09105	COG0288	reversible hydration of carbon dioxide
E5E96_09110	COG2188	Transcriptional regulator
E5E96_09115	COG1228	amidohydrolase
E5E96_09120	COG0010	Belongs to the arginase family
E5E96_09125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5E96_09130	COG2986	histidine ammonia-lyase
E5E96_09135	COG0387	Pfam Sodium calcium exchanger
E5E96_09140	COG2200	EAL domain
E5E96_09145	COG2199	diguanylate cyclase activity
E5E96_09145	COG2200	EAL domain
E5E96_09190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_09195	COG1459	type II secretion system
E5E96_09240	COG1077	Cell shape determining protein MreB Mrl
E5E96_09245	COG1792	Involved in formation and maintenance of cell shape
E5E96_09250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5E96_09255	COG0424	maF-like protein
E5E96_09265	COG3164	Protein of unknown function
E5E96_09275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E96_09280	COG0312	modulator of DNA gyrase
E5E96_09305	COG1263	PTS System
E5E96_09305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_09310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5E96_09325	COG0477	Major facilitator Superfamily
E5E96_09335	COG3437	response regulator, receiver
E5E96_09340	COG0784	Response regulator, receiver
E5E96_09340	COG2205	protein histidine kinase activity
E5E96_09340	COG5002	protein histidine kinase activity
E5E96_09345	COG2172	sigma factor antagonist activity
E5E96_09350	COG1366	Belongs to the anti-sigma-factor antagonist family
E5E96_09370	COG3700	Belongs to the class B bacterial acid phosphatase family
E5E96_09375	COG2321	neutral zinc metallopeptidase
E5E96_09385	COG1639	'signal transduction protein
E5E96_09405	COG0646	methionine synthase
E5E96_09405	COG1410	methionine synthase
E5E96_09410	COG0189	ligase activity
E5E96_09420	COG0642	Histidine kinase
E5E96_09425	COG0745	RESPONSE REGULATOR receiver
E5E96_09440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5E96_09445	COG0352	thiamine-phosphate diphosphorylase activity
E5E96_09450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E96_09460	COG2022	thiamine diphosphate biosynthetic process
E5E96_09465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E96_09485	COG0110	maltose O-acetyltransferase activity
E5E96_09490	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E5E96_09510	COG3706	GGDEF domain
E5E96_09515	COG0814	amino acid
E5E96_09520	COG3932	Exopolysaccharide synthesis, ExoD
E5E96_09540	COG1733	regulation of RNA biosynthetic process
E5E96_09580	COG1494	fructose-1,6-bisphosphatase
E5E96_09595	COG2959	enzyme of heme biosynthesis
E5E96_09605	COG0181	hydroxymethylbilane synthase activity
E5E96_09610	COG3072	Adenylate cyclase
E5E96_09615	COG0400	carboxylic ester hydrolase activity
E5E96_09620	COG1965	Belongs to the frataxin family
E5E96_09630	COG0019	diaminopimelate decarboxylase activity
E5E96_09635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5E96_09650	COG1011	Hydrolase
E5E96_09670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5E96_09675	COG0561	phosphatase activity
E5E96_09690	COG1129	ABC transporter
E5E96_09690	COG0842	Transport permease protein
E5E96_09700	COG1546	Belongs to the CinA family
E5E96_09700	COG1058	Belongs to the CinA family
E5E96_09705	COG1418	mRNA catabolic process
E5E96_09710	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5E96_09720	COG1522	sequence-specific DNA binding
E5E96_09725	COG1368	sulfuric ester hydrolase activity
E5E96_09745	COG1285	pathogenesis
E5E96_09765	COG4221	oxidoreductase activity
E5E96_09795	COG2873	o-acetylhomoserine
E5E96_09805	COG4533	DNA binding
E5E96_09820	COG5380	lipid catabolic process
E5E96_09825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E5E96_09840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5E96_09845	COG2949	membrane
E5E96_09850	COG3291	Pkd domain containing protein
E5E96_09860	COG3539	Fimbrial protein
E5E96_09870	COG3188	usher protein
E5E96_09875	COG3121	Chaperone
E5E96_09880	COG3539	Fimbrial protein
E5E96_09895	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_09905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5E96_09910	COG0596	Alpha beta hydrolase
E5E96_09920	COG1169	isochorismate synthase
E5E96_09925	COG1575	Belongs to the MenA family. Type 1 subfamily
E5E96_09950	COG0513	Belongs to the DEAD box helicase family
E5E96_09955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_09960	COG1988	membrane-bound metal-dependent
E5E96_09975	COG1671	Belongs to the UPF0178 family
E5E96_10000	COG3263	regulation of cellular component size
E5E96_10005	COG3722	fumarate hydratase activity
E5E96_10010	COG0246	Mannitol dehydrogenase
E5E96_10015	COG2213	PTS system mannitol-specific
E5E96_10015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_10025	COG1309	transcriptional regulator
E5E96_10030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E5E96_10040	COG3916	Acyl-homoserine-lactone synthase
E5E96_10045	COG2771	luxR family
E5E96_10060	COG3133	Outer membrane lipoprotein
E5E96_10090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5E96_10100	COG3031	protein transport across the cell outer membrane
E5E96_10110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_10115	COG1459	type II secretion system
E5E96_10120	COG2165	general secretion pathway protein
E5E96_10135	COG2165	general secretion pathway protein
E5E96_10140	COG4795	General secretion pathway protein
E5E96_10155	COG3156	type II secretion system protein K
E5E96_10165	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E5E96_10180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E96_10185	COG1011	Hydrolase
E5E96_10190	COG0494	nUDIX hydrolase
E5E96_10195	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5E96_10200	COG0814	amino acid
E5E96_10205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_10210	COG2207	Transcriptional regulator
E5E96_10210	COG3708	Transcriptional regulator
E5E96_10220	COG0626	cystathionine gamma-synthase activity
E5E96_10225	COG0527	aspartate kinase activity
E5E96_10225	COG0460	homoserine dehydrogenase
E5E96_10235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5E96_10245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5E96_10250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5E96_10260	COG0137	argininosuccinate synthase activity
E5E96_10265	COG0165	Argininosuccinate lyase
E5E96_10285	COG0110	maltose O-acetyltransferase activity
E5E96_10290	COG3174	membrane
E5E96_10295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5E96_10305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5E96_10310	COG4208	sulfate ABC transporter
E5E96_10315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5E96_10320	COG0583	DNA-binding transcription factor activity
E5E96_10325	COG3397	chitin binding
E5E96_10330	COG0840	transmembrane signaling receptor activity
E5E96_10365	COG0793	Belongs to the peptidase S41A family
E5E96_10365	COG4946	Tricorn protease homolog
E5E96_10385	COG1328	CTP reductase activity
E5E96_10390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_10405	COG1448	Aminotransferase
E5E96_10445	COG0513	Belongs to the DEAD box helicase family
E5E96_10465	COG0840	transmembrane signaling receptor activity
E5E96_10480	COG3112	Uncharacterised protein family (UPF0231)
E5E96_10485	COG3835	regulator
E5E96_10490	COG2610	gluconate transmembrane transporter activity
E5E96_10495	COG1929	Belongs to the glycerate kinase type-1 family
E5E96_10510	COG0583	DNA-binding transcription factor activity
E5E96_10515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_10530	COG0347	Belongs to the P(II) protein family
E5E96_10535	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E96_10545	COG3842	ATPase activity
E5E96_10555	COG1438	arginine binding
E5E96_10565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_10570	COG4215	(ABC) transporter
E5E96_10575	COG4160	amino acid transport
E5E96_10580	COG0039	L-malate dehydrogenase activity
E5E96_10585	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E5E96_10590	COG1017	nitric oxide dioxygenase activity
E5E96_10590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_10600	COG4536	flavin adenine dinucleotide binding
E5E96_10605	COG4137	Cytochrome C assembly protein
E5E96_10610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5E96_10615	COG0228	four-way junction DNA binding
E5E96_10620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5E96_10625	COG0336	Belongs to the RNA methyltransferase TrmD family
E5E96_10630	COG0335	large ribosomal subunit rRNA binding
E5E96_10640	COG3066	DNA modification
E5E96_10645	COG1051	belongs to the nudix hydrolase family
E5E96_10655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5E96_10660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5E96_10665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_10675	COG0583	DNA-binding transcription factor activity
E5E96_10680	COG0640	Transcriptional regulator
E5E96_10685	COG0268	Binds directly to 16S ribosomal RNA
E5E96_10690	COG0728	peptidoglycan biosynthetic process
E5E96_10695	COG0196	riboflavin kinase activity
E5E96_10700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5E96_10705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5E96_10710	COG1047	Peptidyl-prolyl cis-trans
E5E96_10715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5E96_10775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E96_10775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5E96_10790	COG1854	S-ribosylhomocysteine lyase activity
E5E96_10795	COG3706	GGDEF domain
E5E96_10800	COG0557	exoribonuclease II activity
E5E96_10805	COG1204	response to ionizing radiation
E5E96_10815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E96_10825	COG2153	protein acetylation
E5E96_10840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5E96_10845	COG1914	H( )-stimulated, divalent metal cation uptake system
E5E96_10850	COG0360	Binds together with S18 to 16S ribosomal RNA
E5E96_10855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5E96_10860	COG0359	binds to the 23S rRNA
E5E96_10865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_10890	COG1238	metal cluster binding
E5E96_10895	COG0612	Peptidase, M16
E5E96_10900	COG2918	glutathione biosynthetic process
E5E96_10910	COG1022	Amp-dependent synthetase and ligase
E5E96_10920	COG0456	acetyltransferase
E5E96_10930	COG0714	Associated with various cellular activities
E5E96_10940	COG5001	Diguanylate cyclase
E5E96_10940	COG3300	MHYT domain
E5E96_10980	COG1902	pentaerythritol trinitrate reductase activity
E5E96_10985	COG1309	transcriptional regulator
E5E96_10995	COG2957	Belongs to the agmatine deiminase family
E5E96_11035	COG0513	Belongs to the DEAD box helicase family
E5E96_11070	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E5E96_11075	COG1858	cytochrome C peroxidase
E5E96_11100	COG2070	2-Nitropropane dioxygenase
E5E96_11130	COG2816	NAD+ diphosphatase activity
E5E96_11135	COG2205	protein histidine kinase activity
E5E96_11140	COG0745	RESPONSE REGULATOR receiver
E5E96_11145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_11150	COG1136	(ABC) transporter
E5E96_11150	COG0577	efflux transmembrane transporter activity
E5E96_11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_11160	COG1126	abc transporter atp-binding protein
E5E96_11165	COG0765	amino acid transport
E5E96_11170	COG0765	amino acid transport
E5E96_11175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E96_11180	COG1505	serine-type exopeptidase activity
E5E96_11200	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_11205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5E96_11220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E96_11225	COG4991	sh3 domain protein
E5E96_11235	COG2816	NAD+ diphosphatase activity
E5E96_11240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5E96_11245	COG1940	carbohydrate kinase activity
E5E96_11250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E96_11255	COG0126	phosphoglycerate kinase activity
E5E96_11265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_11275	COG4232	protein-disulfide reductase activity
E5E96_11305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5E96_11315	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5E96_11320	COG1595	DNA-templated transcription, initiation
E5E96_11325	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E5E96_11340	COG0481	GTPase activity
E5E96_11345	COG0681	Belongs to the peptidase S26 family
E5E96_11350	COG0571	ribonuclease III activity
E5E96_11360	COG1381	Involved in DNA repair and RecF pathway recombination
E5E96_11365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5E96_11380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_11385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_11390	COG3716	PTS system mannose fructose sorbose family IID component
E5E96_11400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_11405	COG2222	sugar isomerase
E5E96_11415	COG1349	DNA-binding transcription factor activity
E5E96_11420	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5E96_11425	COG4807	Protein conserved in bacteria
E5E96_11435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_11440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E96_11445	COG3956	TIGRFAM MazG family protein
E5E96_11450	COG0504	CTP synthase activity
E5E96_11455	COG0148	phosphopyruvate hydratase activity
E5E96_11460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5E96_11465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5E96_11475	COG0585	pseudouridine synthase activity
E5E96_11480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5E96_11485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5E96_11490	COG1238	metal cluster binding
E5E96_11505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5E96_11510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5E96_11515	COG1610	YqeY-like protein
E5E96_11520	COG0358	DNA primase activity
E5E96_11525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5E96_11550	COG0151	Belongs to the GarS family
E5E96_11555	COG0138	bifunctional purine biosynthesis protein purh
E5E96_11565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5E96_11570	COG3036	rescue of stalled ribosome
E5E96_11575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E96_11580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5E96_11590	COG0673	inositol 2-dehydrogenase activity
E5E96_11600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_11605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_11620	COG0477	Major facilitator Superfamily
E5E96_11630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E96_11635	COG1027	Aspartate ammonia-lyase
E5E96_11640	COG3030	protein affecting phage T7 exclusion by the F plasmid
E5E96_11645	COG0534	Mate efflux family protein
E5E96_11650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5E96_11655	COG0459	protein refolding
E5E96_11665	COG5001	Diguanylate cyclase
E5E96_11665	COG3300	MHYT domain
E5E96_11675	COG0564	pseudouridine synthase activity
E5E96_11680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5E96_11720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5E96_11725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E5E96_11730	COG1178	ABC-type Fe3 transport system permease component
E5E96_11735	COG4143	(ABC) transporter
E5E96_11750	COG0066	3-isopropylmalate dehydratase activity
E5E96_11755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5E96_11760	COG0473	3-isopropylmalate dehydrogenase activity
E5E96_11765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E96_11775	COG0671	phosphoesterase, PA-phosphatase related
E5E96_11790	COG0028	Belongs to the TPP enzyme family
E5E96_11800	COG0857	belongs to the CobB CobQ family
E5E96_11800	COG0280	phosphate acetyltransferase
E5E96_11805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5E96_11815	COG3013	Belongs to the UPF0304 family
E5E96_11820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5E96_11825	COG2716	regulation of RNA biosynthetic process
E5E96_11835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E5E96_11840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5E96_11855	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5E96_11875	COG0784	Response regulator, receiver
E5E96_11875	COG2198	Histidine kinase
E5E96_11875	COG5002	protein histidine kinase activity
E5E96_11900	COG0840	transmembrane signaling receptor activity
E5E96_11925	COG1464	Belongs to the NlpA lipoprotein family
E5E96_11930	COG2011	ABC-type metal ion transport system permease component
E5E96_11935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5E96_11950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5E96_11955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5E96_11955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5E96_11960	COG0802	atpase or kinase
E5E96_11970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5E96_11975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5E96_11980	COG1923	regulation of RNA biosynthetic process
E5E96_11985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5E96_11990	COG0330	HflC and HflK could
E5E96_11995	COG0330	HflC and HflK could
E5E96_12000	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E5E96_12005	COG0142	geranyltranstransferase activity
E5E96_12010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5E96_12015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5E96_12020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5E96_12030	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_12045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_12050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5E96_12060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5E96_12065	COG2967	ApaG domain
E5E96_12070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5E96_12075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5E96_12085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5E96_12090	COG3178	'Phosphotransferase
E5E96_12095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5E96_12100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E96_12105	COG2252	PERMEase
E5E96_12115	COG0488	(ABC) transporter
E5E96_12130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E96_12135	COG0741	lytic transglycosylase activity
E5E96_12155	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5E96_12160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_12165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E96_12190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_12200	COG3721	Heme iron utilization protein
E5E96_12205	COG0748	coenzyme F420 binding
E5E96_12225	COG4771	TonB-dependent receptor
E5E96_12235	COG2814	Major facilitator Superfamily
E5E96_12240	COG3655	Transcriptional regulator
E5E96_12250	COG2205	protein histidine kinase activity
E5E96_12250	COG2202	Pas domain
E5E96_12265	COG3397	chitin binding
E5E96_12270	COG2226	methyltransferase
E5E96_12280	COG1765	OsmC-like protein
E5E96_12295	COG3954	Phosphoribulokinase
E5E96_12300	COG2076	Multidrug Resistance protein
E5E96_12305	COG2076	Multidrug Resistance protein
E5E96_12310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5E96_12315	COG0726	polysaccharide deacetylase
E5E96_12320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E96_12320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E96_12325	COG0463	Glycosyl transferase, family 2
E5E96_12330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E96_12340	COG3089	Belongs to the UPF0270 family
E5E96_12345	COG2203	Gaf domain
E5E96_12345	COG4251	negative regulation of phosphorylation
E5E96_12345	COG3706	GGDEF domain
E5E96_12345	COG5001	Diguanylate cyclase
E5E96_12350	COG0429	hydrolase of the alpha beta-hydrolase fold
E5E96_12355	COG0784	Response regulator, receiver
E5E96_12355	COG0835	chemotaxis
E5E96_12365	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5E96_12370	COG1047	Peptidyl-prolyl cis-trans
E5E96_12385	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E96_12390	COG2204	response regulator
E5E96_12410	COG0737	Belongs to the 5'-nucleotidase family
E5E96_12415	COG2200	EAL domain
E5E96_12430	COG0305	Participates in initiation and elongation during chromosome replication
E5E96_12440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_12450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_12460	COG2200	EAL domain
E5E96_12460	COG2199	diguanylate cyclase activity
E5E96_12460	COG2203	Gaf domain
E5E96_12485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E96_12490	COG2201	protein-glutamate methylesterase activity
E5E96_12495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5E96_12505	COG0840	transmembrane signaling receptor activity
E5E96_12510	COG0835	chemotaxis
E5E96_12520	COG0643	Histidine kinase
E5E96_12520	COG2198	Histidine kinase
E5E96_12535	COG0840	transmembrane signaling receptor activity
E5E96_12550	COG1280	lysine exporter protein (LysE YggA)
E5E96_12555	COG0826	peptidase U32
E5E96_12585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E5E96_12610	COG0300	oxidoreductase activity
E5E96_12620	COG0840	transmembrane signaling receptor activity
E5E96_12630	COG0235	Class ii aldolase
E5E96_12635	COG1454	alcohol dehydrogenase
E5E96_12640	COG4977	sequence-specific DNA binding
E5E96_12650	COG4806	L-rhamnose isomerase
E5E96_12660	COG3254	rhamnose metabolic process
E5E96_12710	COG2003	Belongs to the UPF0758 family
E5E96_12755	COG5377	YqaJ viral recombinase family
E5E96_12785	COG0077	Prephenate dehydratase
E5E96_12785	COG1605	Chorismate mutase
E5E96_12815	COG3272	Protein of unknown function (DUF1722)
E5E96_12820	COG0789	Transcriptional regulator
E5E96_12825	COG0415	Belongs to the DNA photolyase family
E5E96_12835	COG4221	oxidoreductase activity
E5E96_12850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5E96_12875	COG0783	Belongs to the Dps family
E5E96_12880	COG1151	hydroxylamine reductase activity
E5E96_12890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E96_12895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_12895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_13050	COG3311	Transcriptional regulator
E5E96_13070	COG3501	Rhs element vgr protein
E5E96_13110	COG2771	luxR family
E5E96_13170	COG0693	protein deglycase activity
E5E96_13175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5E96_13180	COG1666	GTP binding
E5E96_13190	COG2211	Major facilitator Superfamily
E5E96_13200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E96_13210	COG2813	Specifically methylates the guanine in position
E5E96_13215	COG0271	Belongs to the BolA IbaG family
E5E96_13220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_13225	COG1805	sodium ion transport
E5E96_13230	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_13235	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_13240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_13245	COG2871	sodium ion transport
E5E96_13250	COG1477	protein flavinylation
E5E96_13265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5E96_13270	COG0840	transmembrane signaling receptor activity
E5E96_13275	COG0583	DNA-binding transcription factor activity
E5E96_13285	COG2363	Small membrane protein
E5E96_13290	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E5E96_13300	COG0473	3-isopropylmalate dehydrogenase activity
E5E96_13305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_13310	COG1611	Belongs to the LOG family
E5E96_13315	COG3706	GGDEF domain
E5E96_13325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E96_13325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E96_13335	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E5E96_13360	COG3098	single-species biofilm formation
E5E96_13365	COG0564	pseudouridine synthase activity
E5E96_13375	COG4580	involved in the transport of maltose and maltodextrins
E5E96_13385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_13385	COG1263	PTS System
E5E96_13395	COG2171	N-acyltransferase activity
E5E96_13400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5E96_13405	COG0024	Methionine aminopeptidase
E5E96_13410	COG0052	Belongs to the universal ribosomal protein uS2 family
E5E96_13415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5E96_13420	COG0528	UMP kinase activity
E5E96_13425	COG0233	cytoplasmic translational termination
E5E96_13430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5E96_13435	COG0575	Belongs to the CDS family
E5E96_13440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5E96_13445	COG0750	zinc metalloprotease
E5E96_13460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_13465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_13470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_13475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_13480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5E96_13490	COG0825	malonyl-CoA metabolic process
E5E96_13495	COG3710	Transcriptional regulator
E5E96_13500	COG0531	amino acid
E5E96_13505	COG1982	Orn Lys Arg decarboxylase major
E5E96_13510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E96_13525	COG0814	amino acid
E5E96_13535	COG1234	tRNA 3'-trailer cleavage
E5E96_13545	COG1073	alpha beta
E5E96_13550	COG1073	alpha beta
E5E96_13560	COG0531	amino acid
E5E96_13570	COG0488	(ABC) transporter
E5E96_13580	COG3590	peptidase
E5E96_13590	COG3706	GGDEF domain
E5E96_13625	COG0366	Alpha amylase catalytic
E5E96_13640	COG0463	Glycosyl transferase, family 2
E5E96_13655	COG2989	Protein conserved in bacteria
E5E96_13660	COG3108	Peptidase M15
E5E96_13670	COG2860	membrane
E5E96_13685	COG3115	cell septum assembly
E5E96_13690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5E96_13700	COG1328	CTP reductase activity
E5E96_13705	COG0602	queuosine metabolic process
E5E96_13735	COG1566	PFAM secretion protein HlyD family protein
E5E96_13740	COG1846	Transcriptional regulator
E5E96_13755	COG0281	malic enzyme
E5E96_13760	COG3290	protein histidine kinase activity
E5E96_13765	COG4565	transcriptional regulatory protein
E5E96_13770	COG0697	spore germination
E5E96_13780	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_13785	COG3284	Transcriptional regulator
E5E96_13790	COG1960	acyl-CoA dehydrogenase activity
E5E96_13795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5E96_13800	COG0346	lactoylglutathione lyase activity
E5E96_13805	COG0745	RESPONSE REGULATOR receiver
E5E96_13810	COG5002	protein histidine kinase activity
E5E96_13845	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E96_13850	COG1131	(ABC) transporter
E5E96_13870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5E96_13890	COG0019	diaminopimelate decarboxylase activity
E5E96_13895	COG1115	amino acid carrier protein
E5E96_13900	COG0095	Lipoate-protein ligase
E5E96_13905	COG2233	PERMEase
E5E96_13920	COG0534	Mate efflux family protein
E5E96_13930	COG0281	malic enzyme
E5E96_13960	COG0733	neurotransmitter:sodium symporter activity
E5E96_13965	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5E96_13970	COG2199	diguanylate cyclase activity
E5E96_13970	COG2203	Gaf domain
E5E96_13975	COG1566	PFAM secretion protein HlyD family protein
E5E96_13980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_13990	COG1032	radical SAM domain protein
E5E96_14015	COG0673	inositol 2-dehydrogenase activity
E5E96_14025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5E96_14030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E96_14035	COG1196	nuclear chromosome segregation
E5E96_14035	COG0741	lytic transglycosylase activity
E5E96_14035	COG0739	heme binding
E5E96_14040	COG0366	Alpha amylase catalytic
E5E96_14060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_14070	COG0788	formyltetrahydrofolate deformylase activity
E5E96_14075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E96_14085	COG3118	belongs to the thioredoxin family
E5E96_14095	COG0791	NLP P60 protein
E5E96_14100	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E5E96_14115	COG1376	ErfK ybiS ycfS ynhG family protein
E5E96_14115	COG1388	LysM domain
E5E96_14140	COG4869	propanediol catabolic process
E5E96_14150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_14155	COG1882	Formate acetyltransferase
E5E96_14160	COG1454	alcohol dehydrogenase
E5E96_14160	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_14170	COG1454	alcohol dehydrogenase
E5E96_14170	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_14205	COG0583	DNA-binding transcription factor activity
E5E96_14210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E96_14215	COG0243	molybdopterin cofactor binding
E5E96_14225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5E96_14235	COG1960	acyl-CoA dehydrogenase activity
E5E96_14240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_14250	COG0469	pyruvate kinase activity
E5E96_14255	COG1737	Transcriptional regulator
E5E96_14270	COG0745	RESPONSE REGULATOR receiver
E5E96_14275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E96_14290	COG1677	Flagellar hook-basal body complex protein FliE
E5E96_14300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5E96_14355	COG1684	flagellar biosynthetic protein fliR
E5E96_14365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5E96_14390	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E5E96_14395	COG0643	Histidine kinase
E5E96_14395	COG2198	Histidine kinase
E5E96_14395	COG0784	Response regulator, receiver
E5E96_14400	COG2201	protein-glutamate methylesterase activity
E5E96_14405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_14410	COG1360	Flagellar Motor Protein
E5E96_14415	COG1192	Involved in chromosome partitioning
E5E96_14425	COG0835	chemotaxis
E5E96_14440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_14445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_14450	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_14455	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5E96_14460	COG1138	Cytochrome C-type biogenesis protein
E5E96_14465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_14470	COG3088	subunit of a heme lyase
E5E96_14470	COG4235	cytochrome complex assembly
E5E96_14475	COG4235	cytochrome complex assembly
E5E96_14475	COG3088	subunit of a heme lyase
E5E96_14490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5E96_14495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_14495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_14510	COG0259	pyridoxamine-phosphate oxidase activity
E5E96_14515	COG0625	glutathione transferase activity
E5E96_14525	COG3153	acetyltransferase
E5E96_14535	COG2850	peptidyl-arginine hydroxylation
E5E96_14540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5E96_14545	COG2915	High frequency lysogenization protein hflD homolog
E5E96_14550	COG0482	sulfurtransferase activity
E5E96_14560	COG1187	pseudouridine synthase activity
E5E96_14570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_14590	COG5599	Phosphatase
E5E96_14595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_14595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_14595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_14625	COG0456	acetyltransferase
E5E96_14635	COG0789	Transcriptional regulator
E5E96_14640	COG1902	pentaerythritol trinitrate reductase activity
E5E96_14640	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_14645	COG1609	Transcriptional regulator
E5E96_14650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_14650	COG1263	PTS System
E5E96_14655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E96_14670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_14690	COG2207	Transcriptional regulator
E5E96_14695	COG0538	isocitrate dehydrogenase activity
E5E96_14705	COG3048	D-serine ammonia-lyase activity
E5E96_14710	COG2610	gluconate transmembrane transporter activity
E5E96_14715	COG0583	DNA-binding transcription factor activity
E5E96_14725	COG3171	Protein conserved in bacteria
E5E96_14740	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E5E96_14745	COG1715	Restriction endonuclease
E5E96_14755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5E96_14760	COG2867	negative regulation of translational initiation
E5E96_14770	COG0702	epimerase
E5E96_14775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_14780	COG1454	alcohol dehydrogenase
E5E96_14790	COG0564	pseudouridine synthase activity
E5E96_14820	COG1280	lysine exporter protein (LysE YggA)
E5E96_14830	COG3263	regulation of cellular component size
E5E96_14840	COG3263	regulation of cellular component size
E5E96_14850	COG1876	peptidase activity
E5E96_14855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E96_14860	COG1393	Belongs to the ArsC family
E5E96_14875	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E96_14890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E96_14895	COG0017	Asparaginyl-tRNA synthetase
E5E96_14915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E96_14920	COG0156	8-amino-7-oxononanoate synthase activity
E5E96_14925	COG2226	methyltransferase
E5E96_14925	COG1073	alpha beta
E5E96_14930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5E96_14935	COG0501	Belongs to the peptidase M48B family
E5E96_14945	COG3217	Mosc domain protein beta barrel domain protein
E5E96_14945	COG0633	Ferredoxin
E5E96_14945	COG0633	Ferredoxin
E5E96_14945	COG3217	Mosc domain protein beta barrel domain protein
E5E96_14975	COG0534	Mate efflux family protein
E5E96_15015	COG1309	transcriptional regulator
E5E96_15030	COG0791	NLP P60 protein
E5E96_15040	COG0583	DNA-binding transcription factor activity
E5E96_15045	COG0450	alkyl hydroperoxide reductase
E5E96_15065	COG0500	methyltransferase
E5E96_15070	COG4106	trans-aconitate 2-methyltransferase activity
E5E96_15075	COG1801	Protein of unknown function DUF72
E5E96_15080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5E96_15085	COG0217	transcriptional regulatory protein
E5E96_15090	COG2194	sulfuric ester hydrolase activity
E5E96_15095	COG1846	Transcriptional regulator
E5E96_15095	COG1940	carbohydrate kinase activity
E5E96_15100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_15105	COG0363	glucosamine-6-phosphate deaminase activity
E5E96_15110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_15110	COG2190	(PTS) system
E5E96_15110	COG1263	PTS System
E5E96_15125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_15130	COG0735	belongs to the Fur family
E5E96_15140	COG0716	FMN binding
E5E96_15160	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E5E96_15165	COG0033	Phosphoglucomutase
E5E96_15175	COG1846	Transcriptional regulator
E5E96_15190	COG2951	lytic endotransglycosylase activity
E5E96_15195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5E96_15200	COG4136	ATPase activity
E5E96_15220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E96_15230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E96_15235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E96_15245	COG0729	surface antigen
E5E96_15250	COG2911	Protein conserved in bacteria
E5E96_15270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5E96_15280	COG0741	lytic transglycosylase activity
E5E96_15295	COG1607	acyl-coa hydrolase
E5E96_15305	COG3021	interspecies interaction between organisms
E5E96_15310	COG1388	LysM domain
E5E96_15310	COG0741	lytic transglycosylase activity
E5E96_15315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E96_15320	COG2226	methyltransferase
E5E96_15325	COG0328	RNA-DNA hybrid ribonuclease activity
E5E96_15345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5E96_15350	COG2716	regulation of RNA biosynthetic process
E5E96_15365	COG3852	Histidine kinase
E5E96_15375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5E96_15380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5E96_15385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5E96_15390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5E96_15410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5E96_15420	COG0590	tRNA wobble adenosine to inosine editing
E5E96_15425	COG0573	inorganic phosphate transmembrane transporter activity
E5E96_15430	COG0581	inorganic phosphate transmembrane transporter activity
E5E96_15440	COG0704	Plays a role in the regulation of phosphate uptake
E5E96_15445	COG1253	flavin adenine dinucleotide binding
E5E96_15460	COG0531	amino acid
E5E96_15480	COG1126	abc transporter atp-binding protein
E5E96_15485	COG0765	amino acid transport
E5E96_15490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_15500	COG2271	Major facilitator Superfamily
E5E96_15515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E96_15540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5E96_15545	COG0477	Major facilitator Superfamily
E5E96_15550	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5E96_15560	COG1199	ATP-dependent helicase activity
E5E96_15575	COG1448	Aminotransferase
E5E96_15580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E96_15590	COG0302	gtp cyclohydrolase
E5E96_15595	COG0840	transmembrane signaling receptor activity
E5E96_15600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5E96_15605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5E96_15615	COG0583	DNA-binding transcription factor activity
E5E96_15645	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E96_15665	COG1166	arginine decarboxylase activity
E5E96_15680	COG0840	transmembrane signaling receptor activity
E5E96_15685	COG0814	amino acid
E5E96_15695	COG3681	Belongs to the UPF0597 family
E5E96_15710	COG1403	HNH endonuclease
E5E96_15720	COG0346	lactoylglutathione lyase activity
E5E96_15740	COG1187	pseudouridine synthase activity
E5E96_15745	COG2807	transmembrane transport
E5E96_15755	COG0583	DNA-binding transcription factor activity
E5E96_15760	COG2271	Major facilitator Superfamily
E5E96_15790	COG2979	Protein of unknown function (DUF533)
E5E96_15795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_15800	COG1271	oxidase subunit
E5E96_15805	COG1294	oxidase, subunit
E5E96_15815	COG2814	Major facilitator Superfamily
E5E96_15820	COG0656	L-ascorbic acid biosynthetic process
E5E96_15845	COG0583	DNA-binding transcription factor activity
E5E96_15850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5E96_15855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E96_15860	COG2271	Major facilitator Superfamily
E5E96_15865	COG1349	DNA-binding transcription factor activity
E5E96_15880	COG0584	glycerophosphoryl diester phosphodiesterase
E5E96_15885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_15890	COG0287	Prephenate dehydrogenase
E5E96_15890	COG1605	Chorismate mutase
E5E96_15895	COG0583	DNA-binding transcription factor activity
E5E96_15900	COG3085	chromosome segregation
E5E96_15905	COG4574	serine-type endopeptidase inhibitor activity
E5E96_15925	COG1770	oligopeptidase
E5E96_15930	COG4771	TonB-dependent receptor
E5E96_15935	COG3083	sulfuric ester hydrolase activity
E5E96_15940	COG3082	Protein of unknown function (DUF1414)
E5E96_15945	COG3081	Nucleoid-associated protein
E5E96_15955	COG1175	transmembrane transport
E5E96_15960	COG3833	ABC-type maltose transport systems, permease component
E5E96_15965	COG3842	ATPase activity
E5E96_15990	COG0425	Belongs to the sulfur carrier protein TusA family
E5E96_15995	COG4783	chaperone-mediated protein folding
E5E96_16005	COG1393	Belongs to the ArsC family
E5E96_16020	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E5E96_16025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_16030	COG2431	L-lysine efflux transmembrane transporter activity
E5E96_16040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_16060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_16070	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_16080	COG4953	penicillin-binding protein 1C
E5E96_16090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_16090	COG0301	tRNA thio-modification
E5E96_16110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_16155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E96_16175	COG0483	inositol monophosphate 1-phosphatase activity
E5E96_16185	COG0625	glutathione transferase activity
E5E96_16190	COG2814	Major facilitator Superfamily
E5E96_16210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_16215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_16220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5E96_16225	COG0509	glycine decarboxylation via glycine cleavage system
E5E96_16230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E96_16230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E96_16260	COG0798	PFAM Bile acid sodium symporter
E5E96_16265	COG1393	Belongs to the ArsC family
E5E96_16285	COG3634	alkyl hydroperoxide reductase activity
E5E96_16295	COG0517	IMP dehydrogenase activity
E5E96_16300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5E96_16305	COG0343	queuine tRNA-ribosyltransferase activity
E5E96_16310	COG1862	Preprotein translocase
E5E96_16315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_16320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_16335	COG0826	peptidase U32
E5E96_16340	COG0826	peptidase U32
E5E96_16345	COG3154	lipid carrier protein
E5E96_16365	COG1104	cysteine desulfurase activity
E5E96_16370	COG0822	iron-sulfur transferase activity
E5E96_16380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E96_16385	COG0443	Heat shock 70 kDa protein
E5E96_16390	COG0633	Ferredoxin
E5E96_16405	COG0105	UTP biosynthetic process
E5E96_16410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5E96_16425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5E96_16430	COG0124	histidyl-tRNA synthetase
E5E96_16435	COG2976	Protein conserved in bacteria
E5E96_16440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_16445	COG1160	GTP binding
E5E96_16450	COG1645	bacterial-type flagellum-dependent swarming motility
E5E96_16460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5E96_16465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5E96_16465	COG0047	phosphoribosylformylglycinamidine synthase activity
E5E96_16470	COG2199	diguanylate cyclase activity
E5E96_16470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_16485	COG1007	ATP synthesis coupled electron transport
E5E96_16490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_16500	COG0713	ATP synthesis coupled electron transport
E5E96_16505	COG0839	Belongs to the complex I subunit 6 family
E5E96_16510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_16515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5E96_16520	COG1034	ATP synthesis coupled electron transport
E5E96_16535	COG0649	NAD binding
E5E96_16535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_16540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_16545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_16550	COG1360	Flagellar Motor Protein
E5E96_16555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_16570	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5E96_16590	COG0724	RNA recognition motif
E5E96_16595	COG4989	oxidoreductase activity
E5E96_16620	COG3437	response regulator, receiver
E5E96_16625	COG0583	DNA-binding transcription factor activity
E5E96_16635	COG3300	MHYT domain
E5E96_16635	COG5001	Diguanylate cyclase
E5E96_16640	COG0778	Nitroreductase
E5E96_16660	COG0583	DNA-binding transcription factor activity
E5E96_16670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E96_16675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5E96_16680	COG0539	negative regulation of cytoplasmic translation
E5E96_16685	COG0776	regulation of translation
E5E96_16695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5E96_16715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5E96_16720	COG0602	queuosine metabolic process
E5E96_16725	COG3530	Putative quorum-sensing-regulated virulence factor
E5E96_16730	COG2096	Adenosyltransferase
E5E96_16735	COG2916	Histone family protein nucleoid-structuring protein H-NS
E5E96_16740	COG1757	Na H antiporter
E5E96_16745	COG1435	thymidine kinase activity
E5E96_16775	COG3501	Rhs element vgr protein
E5E96_16785	COG3209	COG3209 Rhs family protein
E5E96_16880	COG3501	Rhs element vgr protein
E5E96_16965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5E96_16970	COG1278	Cold shock
E5E96_16975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5E96_16985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5E96_16990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5E96_16995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5E96_17000	COG3134	Outer membrane lipoprotein
E5E96_17005	COG3706	GGDEF domain
E5E96_17010	COG0492	ferredoxin-NADP+ reductase activity
E5E96_17015	COG0686	Belongs to the AlaDH PNT family
E5E96_17025	COG1674	ftsk spoiiie
E5E96_17025	COG0531	amino acid
E5E96_17030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5E96_17035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5E96_17040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5E96_17045	COG1286	toxin biosynthetic process
E5E96_17050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5E96_17060	COG4172	Belongs to the ABC transporter superfamily
E5E96_17070	COG4171	peptide transport system, permease
E5E96_17075	COG4168	peptide transport system, permease
E5E96_17085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E5E96_17090	COG1842	Phage shock protein A
E5E96_17105	COG3106	COG3106 Predicted ATPase
E5E96_17110	COG3768	UPF0283 membrane protein
E5E96_17120	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5E96_17140	COG2199	diguanylate cyclase activity
E5E96_17145	COG2885	chlorophyll binding
E5E96_17150	COG0861	Integral membrane protein TerC family
E5E96_17165	COG1022	Amp-dependent synthetase and ligase
E5E96_17170	COG0295	cytidine deaminase activity
E5E96_17175	COG1346	cytolysis
E5E96_17180	COG1380	Effector of murein hydrolase LrgA
E5E96_17185	COG3345	alpha-galactosidase
E5E96_17195	COG2925	Exonuclease
E5E96_17200	COG2160	L-arabinose isomerase activity
E5E96_17210	COG1069	ribulokinase activity
E5E96_17215	COG1879	ABC-type sugar transport system periplasmic component
E5E96_17225	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E96_17235	COG0583	DNA-binding transcription factor activity
E5E96_17245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E96_17250	COG0254	rRNA binding
E5E96_17265	COG1451	nucleotide metabolic process
E5E96_17280	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E96_17290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5E96_17290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_17295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_17320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5E96_17325	COG1053	succinate dehydrogenase
E5E96_17335	COG0567	Dehydrogenase, E1 component
E5E96_17340	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E96_17345	COG0045	succinate-CoA ligase (ADP-forming) activity
E5E96_17350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5E96_17360	COG2983	Belongs to the UPF0260 family
E5E96_17365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_17375	COG3842	ATPase activity
E5E96_17380	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E96_17390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5E96_17400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_17405	COG1882	Formate acetyltransferase
E5E96_17410	COG2116	formate transmembrane transporter activity
E5E96_17415	COG1944	ATP diphosphatase activity
E5E96_17425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E96_17430	COG0612	Peptidase, M16
E5E96_17445	COG2910	NAD(P)H-binding
E5E96_17450	COG0583	DNA-binding transcription factor activity
E5E96_17465	COG4774	siderophore transport
E5E96_17480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5E96_17490	COG0516	GMP reductase activity
E5E96_17490	COG0517	IMP dehydrogenase activity
E5E96_17520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_17535	COG3033	Beta-eliminating lyase
E5E96_17545	COG1051	belongs to the nudix hydrolase family
E5E96_17550	COG3088	subunit of a heme lyase
E5E96_17550	COG4235	cytochrome complex assembly
E5E96_17555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_17560	COG1138	Cytochrome C-type biogenesis protein
E5E96_17565	COG3301	Polysulphide reductase, NrfD
E5E96_17570	COG0437	4 iron, 4 sulfur cluster binding
E5E96_17575	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E96_17585	COG0247	lactate metabolic process
E5E96_17590	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E5E96_17595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5E96_17600	COG3012	SEC-C Motif Domain Protein
E5E96_17605	COG0840	transmembrane signaling receptor activity
E5E96_17610	COG1940	carbohydrate kinase activity
E5E96_17610	COG1846	Transcriptional regulator
E5E96_17620	COG4565	transcriptional regulatory protein
E5E96_17645	COG0569	domain protein
E5E96_17645	COG2985	domain, Protein
E5E96_17660	COG0556	nucleotide-excision repair
E5E96_17670	COG0586	Pfam SNARE associated Golgi protein
E5E96_17675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5E96_17680	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_17685	COG2186	Transcriptional regulator
E5E96_17690	COG2719	SpoVR family
E5E96_17700	COG2766	serine protein kinase
E5E96_17705	COG0514	ATP-dependent DNA helicase (RecQ)
E5E96_17710	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E5E96_17715	COG0814	amino acid
E5E96_17750	COG0058	SHG alpha-glucan phosphorylase activity
E5E96_17755	COG0471	metal ion transport
E5E96_17760	COG3118	belongs to the thioredoxin family
E5E96_17780	COG1132	(ABC) transporter
E5E96_17795	COG2501	S4 domain
E5E96_17805	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5E96_17830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E96_17835	COG2329	Antibiotic biosynthesis monooxygenase
E5E96_17865	COG1742	UPF0060 membrane protein
E5E96_17875	COG0456	acetyltransferase
E5E96_17880	COG0513	Belongs to the DEAD box helicase family
E5E96_17885	COG0386	Belongs to the glutathione peroxidase family
E5E96_17900	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5E96_17920	COG0583	DNA-binding transcription factor activity
E5E96_17935	COG3593	DNA synthesis involved in DNA repair
E5E96_17990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E96_17995	COG1011	Hydrolase
E5E96_18000	COG1473	amidohydrolase
E5E96_18005	COG0205	6-phosphofructokinase activity
E5E96_18015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E5E96_18020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E96_18030	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E5E96_18035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E5E96_18055	COG0242	peptide deformylase activity
E5E96_18085	COG0384	phenazine biosynthesis protein PhzF
E5E96_18105	COG2824	Alkylphosphonate utilization operon protein PhnA
E5E96_18130	COG0588	phosphoglycerate mutase activity
E5E96_18135	COG3706	GGDEF domain
E5E96_18145	COG2840	Smr protein MutS2
E5E96_18150	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E96_18155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5E96_18165	COG0513	Belongs to the DEAD box helicase family
E5E96_18170	COG5654	RES domain protein
E5E96_18180	COG0814	amino acid
E5E96_18185	COG1609	Transcriptional regulator
E5E96_18190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_18190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_18195	COG1105	Belongs to the carbohydrate kinase PfkB family
E5E96_18200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E5E96_18200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_18200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_18205	COG2140	Oxalate decarboxylase
E5E96_18210	COG1609	Transcriptional regulator
E5E96_18225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_18225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_18230	COG3715	PTS system
E5E96_18235	COG3716	PTS system mannose fructose sorbose family IID component
E5E96_18240	COG2942	2-epimerase
E5E96_18245	COG3313	Fe-S protein
E5E96_18250	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E5E96_18255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_18260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E96_18265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E96_18275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E96_18295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5E96_18300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5E96_18305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5E96_18310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5E96_18315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5E96_18320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_18320	COG0072	phenylalanine-tRNA ligase activity
E5E96_18325	COG0776	regulation of translation
E5E96_18355	COG2199	diguanylate cyclase activity
E5E96_18360	COG1609	Transcriptional regulator
E5E96_18365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_18370	COG1879	ABC-type sugar transport system periplasmic component
E5E96_18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E96_18380	COG1129	ABC transporter
E5E96_18385	COG1869	D-ribose catabolic process
E5E96_18405	COG0037	tRNA processing
E5E96_18410	COG0589	response to stress
E5E96_18415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E96_18440	COG2010	Cytochrome c
E5E96_18455	COG3278	Belongs to the heme-copper respiratory oxidase family
E5E96_18465	COG1956	GAF domain-containing protein
E5E96_18470	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E5E96_18480	COG0308	aminopeptidase N
E5E96_18490	COG2902	Dehydrogenase
E5E96_18495	COG0167	dihydroorotate dehydrogenase activity
E5E96_18515	COG0488	(ABC) transporter
E5E96_18530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_18535	COG1067	ATP-dependent peptidase activity
E5E96_18575	COG4128	Pfam Zonular occludens toxin
E5E96_18595	COG3141	response to X-ray
E5E96_18605	COG4221	oxidoreductase activity
E5E96_18650	COG0372	Belongs to the citrate synthase family
E5E96_18655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E5E96_18665	COG2995	paraquat-inducible protein a
E5E96_18670	COG3008	intermembrane lipid transfer
E5E96_18675	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5E96_18675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_18715	COG0084	hydrolase, TatD family'
E5E96_18720	COG0470	DNA polymerase III
E5E96_18725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5E96_18730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5E96_18735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5E96_18745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E96_18750	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_18760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5E96_18765	COG0416	fatty acid biosynthetic process
E5E96_18770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5E96_18775	COG1399	metal-binding, possibly nucleic acid-binding protein
E5E96_18790	COG2814	Major facilitator Superfamily
E5E96_18795	COG0424	maF-like protein
E5E96_18800	COG0546	phosphoglycolate phosphatase activity
E5E96_18805	COG0564	pseudouridine synthase activity
E5E96_18810	COG1530	ribonuclease E activity
E5E96_18815	COG0306	phosphate transporter
E5E96_18825	COG0717	Belongs to the dCTP deaminase family
E5E96_18830	COG0572	uridine kinase
E5E96_18835	COG0489	protein tyrosine kinase activity
E5E96_18840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_18840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_18845	COG0625	glutathione transferase activity
E5E96_18850	COG1254	Belongs to the acylphosphatase family
E5E96_18855	COG0840	transmembrane signaling receptor activity
E5E96_18860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5E96_18875	COG0709	Synthesizes selenophosphate from selenide and ATP
E5E96_18880	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E5E96_18885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E96_18890	COG3437	response regulator, receiver
E5E96_18900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5E96_18910	COG1643	Atp-dependent helicase
E5E96_18915	COG0517	IMP dehydrogenase activity
E5E96_18915	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5E96_18915	COG0617	tRNA 3'-terminal CCA addition
E5E96_18935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5E96_18945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5E96_18950	COG2832	Protein of unknown function (DUF454)
E5E96_18955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E96_18970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5E96_18975	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_18980	COG0596	Alpha beta hydrolase
E5E96_18980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5E96_18980	COG2226	methyltransferase
E5E96_18990	COG1214	PFAM Peptidase M22, glycoprotease
E5E96_19000	COG1199	ATP-dependent helicase activity
E5E96_19010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5E96_19015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5E96_19020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5E96_19025	COG0131	Imidazoleglycerol-phosphate dehydratase
E5E96_19025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E96_19030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5E96_19035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5E96_19050	COG0784	Response regulator, receiver
E5E96_19050	COG2198	Histidine kinase
E5E96_19050	COG2205	protein histidine kinase activity
E5E96_19055	COG0107	imidazoleglycerol-phosphate synthase activity
E5E96_19060	COG0140	phosphoribosyl-ATP diphosphatase activity
E5E96_19060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5E96_19070	COG2378	regulation of single-species biofilm formation
E5E96_19075	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_19080	COG1288	antiporter activity
E5E96_19090	COG3134	Outer membrane lipoprotein
E5E96_19100	COG2080	2 iron, 2 sulfur cluster binding
E5E96_19105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5E96_19110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5E96_19115	COG2252	PERMEase
E5E96_19120	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_19125	COG2233	PERMEase
E5E96_19140	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_19145	COG0493	'glutamate synthase
E5E96_19145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_19150	COG2068	MobA-Related Protein
E5E96_19155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5E96_19160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5E96_19160	COG3608	succinylglutamate desuccinylase aspartoacylase
E5E96_19165	COG0697	spore germination
E5E96_19170	COG0549	Belongs to the carbamate kinase family
E5E96_19180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E96_19185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5E96_19190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E96_19215	COG1024	Enoyl-CoA hydratase
E5E96_19215	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E96_19220	COG0183	Belongs to the thiolase family
E5E96_19225	COG0714	Associated with various cellular activities
E5E96_19255	COG1595	DNA-templated transcription, initiation
E5E96_19270	COG2067	long-chain fatty acid transport protein
E5E96_19295	COG3123	guanosine phosphorylase activity
E5E96_19300	COG1760	l-serine dehydratase
E5E96_19310	COG1760	l-serine dehydratase
E5E96_19315	COG2951	lytic endotransglycosylase activity
E5E96_19320	COG3100	YcgL domain-containing protein
E5E96_19330	COG2894	cell division
E5E96_19335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5E96_19340	COG3099	Belongs to the UPF0263 family
E5E96_19345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_19385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5E96_19390	COG0697	spore germination
E5E96_19395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E5E96_19400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_19410	COG0307	riboflavin synthase, alpha
E5E96_19420	COG0534	Mate efflux family protein
E5E96_19450	COG0417	DNA replication proofreading
E5E96_19475	COG1560	Kdo2-lipid A biosynthetic process
E5E96_19480	COG1560	Kdo2-lipid A biosynthetic process
E5E96_19490	COG0583	DNA-binding transcription factor activity
E5E96_19495	COG0673	inositol 2-dehydrogenase activity
E5E96_19500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5E96_19505	COG0583	DNA-binding transcription factor activity
E5E96_19515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_19525	COG5001	Diguanylate cyclase
E5E96_19525	COG3300	MHYT domain
E5E96_19530	COG2723	6-phospho-beta-galactosidase activity
E5E96_19535	COG0583	DNA-binding transcription factor activity
E5E96_19580	COG2003	Belongs to the UPF0758 family
E5E96_19605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5E96_19620	COG0582	viral genome integration into host DNA
E5E96_19630	COG0730	response to heat
E5E96_19640	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_19650	COG1024	Enoyl-CoA hydratase
E5E96_19660	COG1960	acyl-CoA dehydrogenase activity
E5E96_19670	COG1960	acyl-CoA dehydrogenase activity
E5E96_19675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5E96_19710	COG1584	GPR1 FUN34 yaaH family protein
E5E96_19725	COG1115	amino acid carrier protein
E5E96_19765	COG1024	Enoyl-CoA hydratase
E5E96_19780	COG3162	membrane
E5E96_19785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E96_19790	COG0488	(ABC) transporter
E5E96_19795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E96_19800	COG0776	regulation of translation
E5E96_19805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5E96_19810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5E96_19815	COG0740	serine-type endopeptidase activity
E5E96_19820	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5E96_19835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E5E96_19840	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E96_19845	COG1136	(ABC) transporter
E5E96_19850	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E96_19865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5E96_19870	COG4166	transmembrane transport
E5E96_19875	COG0697	spore germination
E5E96_19885	COG2062	phosphohistidine phosphatase, SixA
E5E96_19895	COG0500	methyltransferase
E5E96_19935	COG0519	Catalyzes the synthesis of GMP from XMP
E5E96_19935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E96_19940	COG0516	GMP reductase activity
E5E96_19940	COG0517	IMP dehydrogenase activity
E5E96_19945	COG3158	transport of potassium into the cell
E5E96_19965	COG0697	spore germination
E5E96_19970	COG1570	exodeoxyribonuclease VII activity
E5E96_19985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_19990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5E96_19995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5E96_20035	COG4771	TonB-dependent receptor
E5E96_20040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_20045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_20050	COG1120	ATPase activity
E5E96_20055	COG2977	Belongs to the P-Pant transferase superfamily
E5E96_20060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5E96_20065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E96_20075	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_20080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E96_20085	COG3433	isochorismatase activity
E5E96_20085	COG1535	isochorismatase
E5E96_20090	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5E96_20110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_20115	COG3300	MHYT domain
E5E96_20115	COG5001	Diguanylate cyclase
E5E96_20130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_20135	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E5E96_20140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5E96_20145	COG0563	adenylate kinase activity
E5E96_20155	COG0326	Molecular chaperone. Has ATPase activity
E5E96_20165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5E96_20190	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_20200	COG3158	transport of potassium into the cell
E5E96_20205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_20210	COG0651	ATP synthesis coupled electron transport
E5E96_20215	COG0650	Formate hydrogenlyase subunit 4
E5E96_20220	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E5E96_20220	COG3261	NADH dehydrogenase
E5E96_20225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_20230	COG3260	NADH ubiquinone oxidoreductase 20
E5E96_20245	COG1921	L-seryl-tRNASec selenium transferase activity
E5E96_20255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E5E96_20260	COG0298	carbon dioxide binding
E5E96_20270	COG0309	Hydrogenase expression formation protein (HypE)
E5E96_20275	COG0375	protein maturation
E5E96_20280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5E96_20285	COG3842	ATPase activity
E5E96_20295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_20300	COG0601	transmembrane transport
E5E96_20310	COG1773	rubredoxin
E5E96_20315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5E96_20320	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E5E96_20325	COG5557	Pfam Polysulphide reductase, NrfD
E5E96_20330	COG0437	4 iron, 4 sulfur cluster binding
E5E96_20335	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E5E96_20350	COG0643	Histidine kinase
E5E96_20350	COG2198	Histidine kinase
E5E96_20355	COG3290	protein histidine kinase activity
E5E96_20355	COG0840	transmembrane signaling receptor activity
E5E96_20360	COG0835	chemotaxis
E5E96_20370	COG2201	protein-glutamate methylesterase activity
E5E96_20380	COG0840	transmembrane signaling receptor activity
E5E96_20385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_20410	COG0659	secondary active sulfate transmembrane transporter activity
E5E96_20440	COG0672	)-iron permease
E5E96_20460	COG2814	Major facilitator Superfamily
E5E96_20515	COG1139	Iron-sulfur cluster binding protein
E5E96_20525	COG1620	l-lactate permease
E5E96_20530	COG0583	DNA-binding transcription factor activity
E5E96_20540	COG0346	lactoylglutathione lyase activity
E5E96_20545	COG0596	Alpha beta hydrolase
E5E96_20570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E96_20575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5E96_20575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5E96_20580	COG0527	aspartate kinase activity
E5E96_20590	COG1368	sulfuric ester hydrolase activity
E5E96_20595	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5E96_20600	COG4667	esterase of the alpha-beta hydrolase superfamily
E5E96_20610	COG0393	Putative heavy-metal-binding
E5E96_20630	COG1252	NADH dehydrogenase
E5E96_20635	COG3150	esterase
E5E96_20640	COG2233	PERMEase
E5E96_20665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_20670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_20705	COG0537	adenosine 5'-monophosphoramidase activity
E5E96_20720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5E96_20735	COG1301	dicarboxylic acid transport
E5E96_20745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_20750	COG0861	Integral membrane protein TerC family
E5E96_20765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_20770	COG0601	transmembrane transport
E5E96_20780	COG2095	MarC family integral membrane protein
E5E96_20790	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_20790	COG1454	alcohol dehydrogenase
E5E96_20795	COG2199	diguanylate cyclase activity
E5E96_20795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_20800	COG3275	phosphorelay sensor kinase activity
E5E96_20805	COG3279	Response regulator of the LytR AlgR family
E5E96_20810	COG1966	Carbon starvation protein
E5E96_20820	COG1566	PFAM secretion protein HlyD family protein
E5E96_20825	COG1061	Type III restriction enzyme res subunit
E5E96_20830	COG2027	D-alanyl-D-alanine carboxypeptidase
E5E96_20835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5E96_20845	COG0436	Aminotransferase
E5E96_20850	COG1288	antiporter activity
E5E96_20855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E96_20930	COG4397	Mu-like prophage major head subunit gpT
E5E96_20935	COG4388	Caudovirus prohead serine protease
E5E96_20940	COG3706	GGDEF domain
E5E96_20940	COG2203	Gaf domain
E5E96_20940	COG4251	negative regulation of phosphorylation
E5E96_20940	COG5001	Diguanylate cyclase
E5E96_20960	COG4383	Mu-like prophage protein gp29
E5E96_20975	COG0640	Transcriptional regulator
E5E96_21085	COG2932	Transcriptional regulator
E5E96_21100	COG0697	spore germination
E5E96_21105	COG4657	Part of a membrane complex involved in electron transport
E5E96_21110	COG2878	Part of a membrane complex involved in electron transport
E5E96_21120	COG4658	electron transport chain
E5E96_21125	COG4659	FMN binding
E5E96_21130	COG4660	Part of a membrane complex involved in electron transport
E5E96_21135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5E96_21140	COG0346	lactoylglutathione lyase activity
E5E96_21155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5E96_21160	COG2056	Na+-H+ antiporter family
E5E96_21170	COG2050	protein possibly involved in aromatic compounds catabolism
E5E96_21180	COG0277	FAD linked oxidase domain protein
E5E96_21180	COG0247	lactate metabolic process
E5E96_21190	COG1253	flavin adenine dinucleotide binding
E5E96_21195	COG1902	pentaerythritol trinitrate reductase activity
E5E96_21200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5E96_21205	COG0647	UMP catabolic process
E5E96_21210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E96_21210	COG4651	solute:proton antiporter activity
E5E96_21220	COG0367	asparagine synthase
E5E96_21230	COG0625	glutathione transferase activity
E5E96_21235	COG0625	glutathione transferase activity
E5E96_21245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5E96_21260	COG0564	pseudouridine synthase activity
E5E96_21265	COG5001	Diguanylate cyclase
E5E96_21270	COG0840	transmembrane signaling receptor activity
E5E96_21280	COG0392	lysyltransferase activity
E5E96_21280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5E96_21290	COG2194	sulfuric ester hydrolase activity
E5E96_21305	COG1317	bacterial-type flagellum organization
E5E96_21465	COG4790	Type iii secretion
E5E96_21470	COG4794	Type iii secretion
E5E96_21475	COG4791	protein targeting
E5E96_21480	COG4792	protein secretion
E5E96_21555	COG1358	cellular component organization or biogenesis
E5E96_21605	COG3039	Transposase
E5E96_21630	COG0670	Belongs to the BI1 family
E5E96_21635	COG1289	transmembrane transporter activity
E5E96_21640	COG2920	part of a sulfur-relay system
E5E96_21645	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E5E96_21650	COG0285	dihydrofolate synthase activity
E5E96_21655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5E96_21660	COG0101	tRNA pseudouridine synthase activity
E5E96_21670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E96_21675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E96_21680	COG0671	phosphoesterase, PA-phosphatase related
E5E96_21685	COG1464	Belongs to the NlpA lipoprotein family
E5E96_21715	COG0574	Belongs to the PEP-utilizing enzyme family
E5E96_21715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5E96_21720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5E96_21775	COG1242	4 iron, 4 sulfur cluster binding
E5E96_21780	COG0067	glutamate synthase
E5E96_21780	COG0069	glutamate synthase activity
E5E96_21780	COG0070	glutamate synthase
E5E96_21785	COG0493	'glutamate synthase
E5E96_21795	COG0765	amino acid transport
E5E96_21800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_21815	COG0789	Transcriptional regulator
E5E96_21830	COG4104	PAAR repeat-containing protein
E5E96_21840	COG0513	Belongs to the DEAD box helicase family
E5E96_21845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_21880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E96_21885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5E96_21890	COG0505	Belongs to the CarA family
E5E96_21895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5E96_21905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5E96_21910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5E96_21915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E96_21920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5E96_21925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_21935	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E5E96_21945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_21945	COG2205	protein histidine kinase activity
E5E96_21960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_21985	COG0023	Translation Initiation Factor
E5E96_21990	COG2119	membrane
E5E96_22020	COG2199	diguanylate cyclase activity
E5E96_22020	COG2203	Gaf domain
E5E96_22050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E96_22060	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_22065	COG3301	Polysulphide reductase, NrfD
E5E96_22070	COG0437	4 iron, 4 sulfur cluster binding
E5E96_22075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E96_22125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E96_22160	COG2197	response regulator
E5E96_22165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5E96_22170	COG2835	tetraacyldisaccharide 4'-kinase activity
E5E96_22175	COG1663	tetraacyldisaccharide 4'-kinase activity
E5E96_22185	COG0658	competence protein
E5E96_22185	COG2333	competence protein COMEC
E5E96_22200	COG0433	COG0433 Predicted ATPase
E5E96_22225	COG2267	carboxylic ester hydrolase activity
E5E96_22230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5E96_22245	COG0314	molybdopterin synthase activity
E5E96_22250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E5E96_22255	COG0315	cyclic pyranopterin monophosphate synthase activity
E5E96_22260	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E96_22265	COG3005	denitrification pathway
E5E96_22275	COG0348	domain, Protein
E5E96_22280	COG0437	4 iron, 4 sulfur cluster binding
E5E96_22285	COG0243	molybdopterin cofactor binding
E5E96_22295	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_22295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_22300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5E96_22310	COG2197	response regulator
E5E96_22330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5E96_22340	COG0121	glutamine amidotransferase
E5E96_22345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E96_22350	COG1960	acyl-CoA dehydrogenase activity
E5E96_22360	COG0784	Response regulator, receiver
E5E96_22360	COG3437	response regulator, receiver
E5E96_22365	COG2239	Acts as a magnesium transporter
E5E96_22385	COG1706	bacterial-type flagellum-dependent cell motility
E5E96_22390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5E96_22400	COG4787	bacterial-type flagellum-dependent cell motility
E5E96_22420	COG1815	bacterial-type flagellum-dependent cell motility
E5E96_22425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5E96_22430	COG0784	Response regulator, receiver
E5E96_22430	COG0835	chemotaxis
E5E96_22435	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E5E96_22450	COG0622	Phosphoesterase
E5E96_22480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E96_22485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_22490	COG1882	Formate acetyltransferase
E5E96_22495	COG1349	DNA-binding transcription factor activity
E5E96_22530	COG1278	Cold shock
E5E96_22570	COG3132	Protein of unknown function, DUF480
E5E96_22590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5E96_22610	COG0110	maltose O-acetyltransferase activity
E5E96_22630	COG0110	maltose O-acetyltransferase activity
E5E96_22655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis