locus-tag	class	description
E5E97_00010	COG0038	chloride channel
E5E97_00015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5E97_00030	COG0671	phosphoesterase, PA-phosphatase related
E5E97_00040	COG0784	Response regulator, receiver
E5E97_00040	COG3437	response regulator, receiver
E5E97_00050	COG2076	Multidrug Resistance protein
E5E97_00060	COG0346	lactoylglutathione lyase activity
E5E97_00070	COG1643	Atp-dependent helicase
E5E97_00080	COG1489	DNA binding
E5E97_00085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5E97_00090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E97_00105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5E97_00110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5E97_00130	COG1924	4 iron, 4 sulfur cluster binding
E5E97_00135	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E5E97_00140	COG0842	Transport permease protein
E5E97_00145	COG1131	(ABC) transporter
E5E97_00160	COG0163	prenyltransferase activity
E5E97_00165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E97_00170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5E97_00190	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E5E97_00205	COG1136	(ABC) transporter
E5E97_00225	COG0840	transmembrane signaling receptor activity
E5E97_00240	COG0529	Catalyzes the synthesis of activated sulfate
E5E97_00245	COG3273	potassium ion transport
E5E97_00245	COG0471	metal ion transport
E5E97_00250	COG2895	sulfate adenylyltransferase (ATP) activity
E5E97_00255	COG0175	sulfate reduction
E5E97_00260	COG1648	precorrin-2 dehydrogenase activity
E5E97_00260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E97_00265	COG0330	HflC and HflK could
E5E97_00270	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5E97_00275	COG0517	IMP dehydrogenase activity
E5E97_00275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E97_00280	COG0488	(ABC) transporter
E5E97_00290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5E97_00295	COG0583	DNA-binding transcription factor activity
E5E97_00340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E97_00350	COG0668	transmembrane transport
E5E97_00360	COG2731	YhcH YjgK YiaL family protein
E5E97_00375	COG1794	racemase activity, acting on amino acids and derivatives
E5E97_00390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E97_00415	COG0733	neurotransmitter:sodium symporter activity
E5E97_00425	COG0733	neurotransmitter:sodium symporter activity
E5E97_00440	COG0561	phosphatase activity
E5E97_00475	COG1846	Transcriptional regulator
E5E97_00480	COG1764	response to oxidative stress
E5E97_00485	COG2130	NADP-dependent
E5E97_00490	COG1051	belongs to the nudix hydrolase family
E5E97_00510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5E97_00515	COG1640	4-alpha-glucanotransferase
E5E97_00520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E97_00525	COG0676	glucose-6-phosphate 1-epimerase activity
E5E97_00530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5E97_00535	COG0840	transmembrane signaling receptor activity
E5E97_00610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E5E97_00615	COG2885	chlorophyll binding
E5E97_00620	COG0823	Involved in the tonB-independent uptake of proteins
E5E97_00635	COG0811	peptide transport
E5E97_00640	COG0824	Thioesterase
E5E97_00645	COG3790	cyd operon protein YbgE
E5E97_00650	COG4890	Cyd operon protein YbgT
E5E97_00655	COG1294	oxidase, subunit
E5E97_00660	COG1271	oxidase subunit
E5E97_00670	COG0632	four-way junction helicase activity
E5E97_00675	COG0840	transmembrane signaling receptor activity
E5E97_00680	COG0442	prolyl-tRNA aminoacylation
E5E97_00685	COG4221	oxidoreductase activity
E5E97_00700	COG1024	Enoyl-CoA hydratase
E5E97_00720	COG4166	transmembrane transport
E5E97_00735	COG1872	DUF167
E5E97_00740	COG0762	integral membrane protein
E5E97_00745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5E97_00750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5E97_00765	COG3022	response to hydroperoxide
E5E97_00770	COG0513	Belongs to the DEAD box helicase family
E5E97_00775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5E97_00800	COG0735	belongs to the Fur family
E5E97_00805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E97_00820	COG0776	regulation of translation
E5E97_00830	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E5E97_00855	COG0560	Phosphoserine phosphatase
E5E97_00865	COG5001	Diguanylate cyclase
E5E97_00865	COG3447	MASE1 domain protein
E5E97_00865	COG5002	protein histidine kinase activity
E5E97_00870	COG0813	purine-nucleoside phosphorylase activity
E5E97_00875	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5E97_00880	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5E97_00885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E97_00895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E97_00900	COG0084	hydrolase, TatD family'
E5E97_00915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E97_00920	COG0004	ammonium transporteR
E5E97_01005	COG1160	GTP binding
E5E97_01015	COG0582	viral genome integration into host DNA
E5E97_01025	COG4974	Belongs to the 'phage' integrase family
E5E97_01035	COG2932	Transcriptional regulator
E5E97_01100	COG4695	Portal protein
E5E97_01150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5E97_01225	COG0795	lipopolysaccharide-transporting ATPase activity
E5E97_01230	COG0795	lipopolysaccharide-transporting ATPase activity
E5E97_01235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E97_01240	COG2927	DNA polymerase III (CHI subunit)
E5E97_01250	COG1253	flavin adenine dinucleotide binding
E5E97_01255	COG0586	Pfam SNARE associated Golgi protein
E5E97_01260	COG1686	Belongs to the peptidase S11 family
E5E97_01295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E5E97_01300	COG0527	aspartate kinase activity
E5E97_01305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5E97_01315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5E97_01320	COG1546	Belongs to the CinA family
E5E97_01325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5E97_01345	COG3068	Protein conserved in bacteria
E5E97_01355	COG0739	heme binding
E5E97_01375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E5E97_01380	COG1121	(ABC) transporter
E5E97_01385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5E97_01390	COG0583	DNA-binding transcription factor activity
E5E97_01395	COG0697	spore germination
E5E97_01400	COG1573	uracil-dna glycosylase
E5E97_01405	COG2962	Rard protein
E5E97_01415	COG2827	Endonuclease containing a URI domain
E5E97_01430	COG1842	Phage shock protein A
E5E97_01435	COG0204	Acyl-transferase
E5E97_01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E97_01520	COG1289	transmembrane transporter activity
E5E97_01525	COG1566	PFAM secretion protein HlyD family protein
E5E97_01540	COG1051	belongs to the nudix hydrolase family
E5E97_01545	COG3150	esterase
E5E97_01555	COG3151	Protein conserved in bacteria
E5E97_01560	COG0494	nUDIX hydrolase
E5E97_01565	COG1538	Outer membrane efflux protein
E5E97_01570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5E97_01570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5E97_01575	COG1560	Kdo2-lipid A biosynthetic process
E5E97_01590	COG1392	Phosphate transport regulator
E5E97_01595	COG0306	phosphate transporter
E5E97_01600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5E97_01630	COG0583	DNA-binding transcription factor activity
E5E97_01635	COG1380	Effector of murein hydrolase LrgA
E5E97_01640	COG1346	cytolysis
E5E97_01655	COG0617	tRNA 3'-terminal CCA addition
E5E97_01660	COG3267	Type II secretory pathway component ExeA
E5E97_01660	COG3409	Peptidoglycan-binding domain 1 protein
E5E97_01670	COG1194	a g-specific adenine glycosylase
E5E97_01675	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E5E97_01685	COG3111	PFAM Bacterial OB fold (BOF) protein
E5E97_01690	COG3240	lipase activity
E5E97_01705	COG3009	Protein conserved in bacteria
E5E97_01710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E97_01710	COG3008	intermembrane lipid transfer
E5E97_01715	COG2995	paraquat-inducible protein a
E5E97_01725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E97_01735	COG4251	negative regulation of phosphorylation
E5E97_01735	COG2203	Gaf domain
E5E97_01735	COG5001	Diguanylate cyclase
E5E97_01735	COG3706	GGDEF domain
E5E97_01740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5E97_01745	COG2813	Specifically methylates the guanine in position
E5E97_01750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E97_01755	COG0297	glycogen (starch) synthase activity
E5E97_01795	COG1757	Na H antiporter
E5E97_01800	COG0583	DNA-binding transcription factor activity
E5E97_01805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5E97_01810	COG3842	ATPase activity
E5E97_01815	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E97_01820	COG1177	transmembrane transport
E5E97_01825	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_01835	COG5006	permease, DMT superfamily
E5E97_01840	COG1522	sequence-specific DNA binding
E5E97_01845	COG0110	maltose O-acetyltransferase activity
E5E97_01850	COG0366	Alpha amylase catalytic
E5E97_01855	COG1263	PTS System
E5E97_01855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_01875	COG0252	asparaginase activity
E5E97_01890	COG1803	Methylglyoxal synthase
E5E97_01915	COG1444	tRNA N-acetyltransferase activity
E5E97_01925	COG0835	chemotaxis
E5E97_01925	COG0784	Response regulator, receiver
E5E97_01970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5E97_01975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5E97_01990	COG0477	Major facilitator Superfamily
E5E97_01995	COG0523	cobalamin synthesis protein
E5E97_02005	COG1280	lysine exporter protein (LysE YggA)
E5E97_02015	COG2200	EAL domain
E5E97_02020	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5E97_02030	COG0840	transmembrane signaling receptor activity
E5E97_02035	COG0840	transmembrane signaling receptor activity
E5E97_02045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E97_02050	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E97_02055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5E97_02060	COG2186	Transcriptional regulator
E5E97_02095	COG1459	type II secretion system
E5E97_02110	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E5E97_02115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5E97_02120	COG0494	nUDIX hydrolase
E5E97_02130	COG0653	protein targeting
E5E97_02140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E5E97_02145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5E97_02150	COG0849	cell division
E5E97_02155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5E97_02160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E97_02165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5E97_02170	COG0772	Belongs to the SEDS family
E5E97_02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5E97_02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5E97_02185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5E97_02195	COG0768	penicillin binding
E5E97_02200	COG3116	cell division
E5E97_02205	COG0275	rRNA processing
E5E97_02210	COG2001	Belongs to the MraZ family
E5E97_02220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5E97_02225	COG3107	peptidoglycan biosynthetic process
E5E97_02230	COG0792	nuclease activity
E5E97_02235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E97_02240	COG2823	Periplasmic or secreted lipoprotein
E5E97_02245	COG2969	positive regulation of protein catabolic process
E5E97_02250	COG0625	glutathione transferase activity
E5E97_02255	COG2857	Cytochrome c1
E5E97_02260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5E97_02265	COG0723	plastoquinol--plastocyanin reductase activity
E5E97_02270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5E97_02275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5E97_02280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5E97_02290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E97_02295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E97_02325	COG3964	amidohydrolase
E5E97_02345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_02350	COG1660	Displays ATPase and GTPase activities
E5E97_02355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_02365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5E97_02370	COG1137	ATPase activity
E5E97_02375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5E97_02380	COG3117	lipopolysaccharide transmembrane transporter activity
E5E97_02385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5E97_02390	COG0517	IMP dehydrogenase activity
E5E97_02390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E97_02395	COG1127	ABC transporter
E5E97_02400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5E97_02405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E97_02410	COG2854	intermembrane phospholipid transfer
E5E97_02420	COG5007	Belongs to the BolA IbaG family
E5E97_02425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5E97_02430	COG0312	modulator of DNA gyrase
E5E97_02435	COG3028	Belongs to the UPF0307 family
E5E97_02445	COG2926	Belongs to the UPF0265 family
E5E97_02475	COG1396	sequence-specific DNA binding
E5E97_02480	COG3135	benzoate transporter
E5E97_02505	COG0840	transmembrane signaling receptor activity
E5E97_02510	COG3047	cAMP biosynthetic process
E5E97_02515	COG3706	GGDEF domain
E5E97_02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5E97_02525	COG2197	response regulator
E5E97_02530	COG0629	single-stranded DNA binding
E5E97_02555	COG1278	Cold shock
E5E97_02560	COG4771	TonB-dependent receptor
E5E97_02565	COG2203	Gaf domain
E5E97_02565	COG5001	Diguanylate cyclase
E5E97_02565	COG4251	negative regulation of phosphorylation
E5E97_02565	COG3706	GGDEF domain
E5E97_02575	COG0745	RESPONSE REGULATOR receiver
E5E97_02600	COG3706	GGDEF domain
E5E97_02610	COG0346	lactoylglutathione lyase activity
E5E97_02630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5E97_02635	COG1074	ATP-dependent DNA helicase activity
E5E97_02640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5E97_02645	COG2259	Doxx family
E5E97_02650	COG1741	Belongs to the pirin family
E5E97_02660	COG0583	DNA-binding transcription factor activity
E5E97_02685	COG1175	transmembrane transport
E5E97_02695	COG3842	ATPase activity
E5E97_02725	COG1247	-acetyltransferase
E5E97_02730	COG0753	catalase activity
E5E97_02755	COG0494	nUDIX hydrolase
E5E97_02760	COG0628	permease
E5E97_02765	COG4221	oxidoreductase activity
E5E97_02770	COG2957	Belongs to the agmatine deiminase family
E5E97_02780	COG3284	Transcriptional regulator
E5E97_02795	COG1461	Dihydroxyacetone kinase
E5E97_02800	COG2376	Dihydroxyacetone kinase
E5E97_02805	COG2252	PERMEase
E5E97_02840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E97_02845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E97_02850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5E97_02855	COG0049	tRNA binding
E5E97_02860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5E97_02865	COG2168	tRNA wobble position uridine thiolation
E5E97_02870	COG2923	Belongs to the DsrF TusC family
E5E97_02880	COG0251	oxidation-reduction process
E5E97_02885	COG2964	Protein conserved in bacteria
E5E97_02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5E97_02895	COG0085	RNA polymerase activity
E5E97_02900	COG0222	ribosome binding
E5E97_02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5E97_02910	COG0081	regulation of translation
E5E97_02915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5E97_02920	COG0250	Participates in transcription elongation, termination and antitermination
E5E97_02935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E97_02960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5E97_02965	COG0569	domain protein
E5E97_02970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E97_02990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5E97_02995	COG3005	denitrification pathway
E5E97_03000	COG0243	molybdopterin cofactor binding
E5E97_03010	COG2205	protein histidine kinase activity
E5E97_03015	COG0745	RESPONSE REGULATOR receiver
E5E97_03030	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5E97_03050	COG2204	response regulator
E5E97_03060	COG2205	protein histidine kinase activity
E5E97_03085	COG5413	integral membrane protein
E5E97_03095	COG1522	sequence-specific DNA binding
E5E97_03100	COG2502	aspartate--ammonia ligase
E5E97_03110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5E97_03115	COG0542	response to heat
E5E97_03125	COG0564	pseudouridine synthase activity
E5E97_03130	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E97_03135	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E97_03145	COG3681	Belongs to the UPF0597 family
E5E97_03155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5E97_03160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5E97_03165	COG1979	alcohol dehydrogenase
E5E97_03170	COG2207	Transcriptional regulator
E5E97_03175	COG3040	lipid binding
E5E97_03185	COG0688	phosphatidylethanolamine metabolic process
E5E97_03205	COG0540	Belongs to the ATCase OTCase family
E5E97_03210	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E5E97_03215	COG1438	arginine binding
E5E97_03220	COG1288	antiporter activity
E5E97_03225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E97_03255	COG0840	transmembrane signaling receptor activity
E5E97_03275	COG3250	beta-galactosidase activity
E5E97_03280	COG1609	Transcriptional regulator
E5E97_03285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E97_03295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5E97_03300	COG2017	converts alpha-aldose to the beta-anomer
E5E97_03305	COG0667	Aldo Keto reductase
E5E97_03310	COG1968	undecaprenyl-diphosphatase activity
E5E97_03315	COG3806	Anti-sigma factor
E5E97_03320	COG1595	DNA-templated transcription, initiation
E5E97_03340	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5E97_03345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5E97_03350	COG0477	Major facilitator Superfamily
E5E97_03360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E97_03370	COG2116	formate transmembrane transporter activity
E5E97_03375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E97_03375	COG1648	precorrin-2 dehydrogenase activity
E5E97_03390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E97_03395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5E97_03405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5E97_03415	COG0514	ATP-dependent DNA helicase (RecQ)
E5E97_03420	COG2050	protein possibly involved in aromatic compounds catabolism
E5E97_03435	COG2258	MOSC domain
E5E97_03440	COG1177	transmembrane transport
E5E97_03445	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E97_03450	COG3842	ATPase activity
E5E97_03470	COG0174	glutamine synthetase
E5E97_03490	COG3045	CreA protein
E5E97_03495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E97_03500	COG0443	Heat shock 70 kDa protein
E5E97_03515	COG0366	Alpha amylase catalytic
E5E97_03520	COG1086	Polysaccharide biosynthesis protein
E5E97_03525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E97_03555	COG1215	transferase activity, transferring glycosyl groups
E5E97_03565	COG1442	glycosyl transferase family 8
E5E97_03570	COG1215	transferase activity, transferring glycosyl groups
E5E97_03585	COG0318	PFAM AMP-dependent synthetase and ligase
E5E97_03590	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_03605	COG1083	cytidylyl-transferase
E5E97_03615	COG2089	acid synthase
E5E97_03635	COG4310	Domain of unknown function (DUF2172)
E5E97_03670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E97_03675	COG0745	RESPONSE REGULATOR receiver
E5E97_03680	COG2205	protein histidine kinase activity
E5E97_03690	COG0281	malic enzyme
E5E97_03695	COG0702	epimerase
E5E97_03700	COG0254	rRNA binding
E5E97_03705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5E97_03725	COG0129	dihydroxy-acid dehydratase activity
E5E97_03735	COG3978	acetolactate synthase activity
E5E97_03750	COG0606	chelatase, subunit chli
E5E97_03755	COG0204	Acyl-transferase
E5E97_03760	COG0204	Acyl-transferase
E5E97_03765	COG1683	Conserved Protein
E5E97_03775	COG1335	isochorismatase
E5E97_03785	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5E97_03790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E5E97_03795	COG3639	organic phosphonate transmembrane transporter activity
E5E97_03800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E97_03805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5E97_03815	COG3084	Protein conserved in bacteria
E5E97_03820	COG4251	negative regulation of phosphorylation
E5E97_03820	COG3706	GGDEF domain
E5E97_03820	COG2203	Gaf domain
E5E97_03820	COG5001	Diguanylate cyclase
E5E97_03825	COG0789	Transcriptional regulator
E5E97_03835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5E97_03840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5E97_03845	COG1561	YicC-like family, N-terminal region
E5E97_03865	COG3306	glycosyltransferase involved in LPS biosynthesis
E5E97_03880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E97_03890	COG0156	8-amino-7-oxononanoate synthase activity
E5E97_03895	COG1063	alcohol dehydrogenase
E5E97_03900	COG3245	cytochrome
E5E97_03915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E97_03920	COG2166	iron-sulfur cluster assembly
E5E97_03925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5E97_03960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5E97_03965	COG4206	TonB-dependent receptor
E5E97_03970	COG0583	DNA-binding transcription factor activity
E5E97_03985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5E97_03990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5E97_03995	COG2223	nitrite transmembrane transporter activity
E5E97_04000	COG3279	Response regulator of the LytR AlgR family
E5E97_04005	COG3275	phosphorelay sensor kinase activity
E5E97_04035	COG3188	usher protein
E5E97_04055	COG2223	nitrite transmembrane transporter activity
E5E97_04060	COG2081	HI0933 family
E5E97_04065	COG1528	Iron-storage protein
E5E97_04070	COG2199	diguanylate cyclase activity
E5E97_04075	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E97_04080	COG0589	response to stress
E5E97_04120	COG3642	lipopolysaccharide core region biosynthetic process
E5E97_04125	COG0859	PFAM glycosyl transferase family 9
E5E97_04135	COG1758	RNA polymerase activity
E5E97_04140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E97_04145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E97_04150	COG2267	carboxylic ester hydrolase activity
E5E97_04155	COG0561	phosphatase activity
E5E97_04180	COG2271	Major facilitator Superfamily
E5E97_04185	COG0469	pyruvate kinase activity
E5E97_04215	COG1309	transcriptional regulator
E5E97_04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_04225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E97_04230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_04230	COG4191	Histidine kinase
E5E97_04235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E97_04260	COG2205	protein histidine kinase activity
E5E97_04265	COG0745	RESPONSE REGULATOR receiver
E5E97_04270	COG2814	Major facilitator Superfamily
E5E97_04285	COG3977	Valine--pyruvate aminotransferase
E5E97_04290	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E97_04295	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E97_04300	COG2378	regulation of single-species biofilm formation
E5E97_04315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5E97_04320	COG0592	DNA-directed DNA polymerase activity
E5E97_04325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5E97_04340	COG1126	abc transporter atp-binding protein
E5E97_04345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5E97_04350	COG0594	ribonuclease P activity
E5E97_04355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5E97_04360	COG0706	membrane insertase activity
E5E97_04365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5E97_04380	COG1120	ATPase activity
E5E97_04385	COG4615	Cyclic peptide transporter
E5E97_04390	COG4774	siderophore transport
E5E97_04395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E97_04400	COG0445	tRNA wobble uridine modification
E5E97_04405	COG0357	Ribosomal RNA small subunit methyltransferase G
E5E97_04410	COG1192	Involved in chromosome partitioning
E5E97_04415	COG1475	DNA binding
E5E97_04425	COG0356	it plays a direct role in the translocation of protons across the membrane
E5E97_04435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5E97_04440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5E97_04445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5E97_04450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5E97_04455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5E97_04460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5E97_04465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5E97_04470	COG4452	Inner membrane protein CreD
E5E97_04480	COG2205	protein histidine kinase activity
E5E97_04485	COG0745	RESPONSE REGULATOR receiver
E5E97_04490	COG1349	DNA-binding transcription factor activity
E5E97_04495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5E97_04500	COG2771	luxR family
E5E97_04510	COG0811	peptide transport
E5E97_04515	COG0811	peptide transport
E5E97_04520	COG0848	biopolymer transport protein
E5E97_04525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E5E97_04570	COG0402	S-adenosylhomocysteine deaminase activity
E5E97_04575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5E97_04585	COG3165	ubiquinone biosynthetic process from chorismate
E5E97_04590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5E97_04600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E97_04605	COG0805	protein transport
E5E97_04610	COG0084	hydrolase, TatD family'
E5E97_04630	COG0742	ribosomal rna small subunit methyltransferase
E5E97_04645	COG0248	Ppx GppA phosphatase
E5E97_04650	COG0513	Belongs to the DEAD box helicase family
E5E97_04655	COG3118	belongs to the thioredoxin family
E5E97_04670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5E97_04695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E97_04735	COG1609	Transcriptional regulator
E5E97_04750	COG2188	Transcriptional regulator
E5E97_04755	COG3604	Transcriptional regulator
E5E97_04760	COG0426	domain, Protein
E5E97_04760	COG1773	rubredoxin
E5E97_04775	COG0348	domain, Protein
E5E97_04780	COG0814	amino acid
E5E97_04815	COG0529	Catalyzes the synthesis of activated sulfate
E5E97_04825	COG0751	glycine-tRNA ligase activity
E5E97_04830	COG0752	glycyl-tRNA synthetase alpha subunit
E5E97_04835	COG2818	Glycosylase
E5E97_04840	COG1335	isochorismatase
E5E97_04845	COG2885	chlorophyll binding
E5E97_04850	COG0251	oxidation-reduction process
E5E97_04855	COG0425	Belongs to the sulfur carrier protein TusA family
E5E97_04875	COG0745	RESPONSE REGULATOR receiver
E5E97_04880	COG0183	Belongs to the thiolase family
E5E97_04885	COG1024	Enoyl-CoA hydratase
E5E97_04885	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E97_04890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E97_04895	COG0006	proline dipeptidase activity
E5E97_04900	COG1739	Uncharacterized protein family UPF0029
E5E97_04905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E97_04910	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E5E97_04950	COG0583	DNA-binding transcription factor activity
E5E97_04955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5E97_04960	COG0166	Belongs to the GPI family
E5E97_04975	COG0668	transmembrane transport
E5E97_04980	COG1309	transcriptional regulator
E5E97_04985	COG0756	dUTP diphosphatase activity
E5E97_04990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5E97_04995	COG2003	Belongs to the UPF0758 family
E5E97_05000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5E97_05005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5E97_05015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5E97_05020	COG2990	Protein conserved in bacteria
E5E97_05025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5E97_05030	COG0859	PFAM glycosyl transferase family 9
E5E97_05035	COG0463	Glycosyl transferase, family 2
E5E97_05040	COG0859	PFAM glycosyl transferase family 9
E5E97_05045	COG1519	Transferase
E5E97_05065	COG1609	Transcriptional regulator
E5E97_05070	COG0604	alcohol dehydrogenase
E5E97_05095	COG3161	chorismate lyase activity
E5E97_05100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5E97_05105	COG2937	Belongs to the GPAT DAPAT family
E5E97_05110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E97_05135	COG0534	Mate efflux family protein
E5E97_05140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5E97_05145	COG2205	protein histidine kinase activity
E5E97_05150	COG0745	RESPONSE REGULATOR receiver
E5E97_05160	COG1045	serine acetyltransferase
E5E97_05170	COG3074	FtsZ-dependent cytokinesis
E5E97_05175	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E5E97_05185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E97_05185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E97_05190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5E97_05225	COG1609	Transcriptional regulator
E5E97_05230	COG3250	beta-galactosidase activity
E5E97_05235	COG2731	YhcH YjgK YiaL family protein
E5E97_05240	COG0531	amino acid
E5E97_05245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E97_05250	COG0531	amino acid
E5E97_05255	COG0385	Bile acid
E5E97_05260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5E97_05280	COG0583	DNA-binding transcription factor activity
E5E97_05305	COG0210	DNA helicase
E5E97_05330	COG0583	DNA-binding transcription factor activity
E5E97_05385	COG1280	lysine exporter protein (LysE YggA)
E5E97_05395	COG2391	methyltransferase activity
E5E97_05400	COG0840	transmembrane signaling receptor activity
E5E97_05410	COG1280	lysine exporter protein (LysE YggA)
E5E97_05420	COG2962	Rard protein
E5E97_05430	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_05435	COG1396	sequence-specific DNA binding
E5E97_05450	COG0519	Catalyzes the synthesis of GMP from XMP
E5E97_05450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E97_05455	COG0686	Belongs to the AlaDH PNT family
E5E97_05460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E97_05480	COG1322	Protein conserved in bacteria
E5E97_05485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E97_05490	COG0569	domain protein
E5E97_05495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E97_05495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E97_05500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E97_05505	COG0242	peptide deformylase activity
E5E97_05515	COG0758	DNA mediated transformation
E5E97_05520	COG2922	Belongs to the Smg family
E5E97_05525	COG0551	DNA topoisomerase type I activity
E5E97_05540	COG0408	coproporphyrinogen oxidase activity
E5E97_05545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5E97_05555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5E97_05570	COG3078	GTPase activator activity
E5E97_05580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E97_05585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5E97_05590	COG2204	response regulator
E5E97_05595	COG3852	Histidine kinase
E5E97_05605	COG0174	glutamine synthetase
E5E97_05615	COG1295	ribonuclease BN
E5E97_05620	COG1295	ribonuclease BN
E5E97_05625	COG1490	D-aminoacyl-tRNA deacylase activity
E5E97_05635	COG0456	acetyltransferase
E5E97_05645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5E97_05650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E97_05655	COG2610	gluconate transmembrane transporter activity
E5E97_05660	COG3265	gluconokinase activity
E5E97_05665	COG0129	dihydroxy-acid dehydratase activity
E5E97_05670	COG0800	Aldolase
E5E97_05675	COG1609	Transcriptional regulator
E5E97_05685	COG4942	peptidase
E5E97_05690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5E97_05695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E97_05700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5E97_05705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5E97_05710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5E97_05710	COG0316	Belongs to the HesB IscA family
E5E97_05715	COG1040	competence protein
E5E97_05725	COG0596	Alpha beta hydrolase
E5E97_05745	COG2183	response to ionizing radiation
E5E97_05750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E97_05755	COG0745	RESPONSE REGULATOR receiver
E5E97_05770	COG0051	transcription antitermination factor activity, RNA binding
E5E97_05775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5E97_05780	COG0088	Forms part of the polypeptide exit tunnel
E5E97_05785	COG0089	rRNA binding
E5E97_05790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5E97_05795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5E97_05800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5E97_05805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5E97_05810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5E97_05815	COG0255	Belongs to the universal ribosomal protein uL29 family
E5E97_05820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5E97_05825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5E97_05830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5E97_05835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5E97_05840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5E97_05845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5E97_05850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5E97_05855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5E97_05860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5E97_05865	COG1841	ribosomal large subunit assembly
E5E97_05870	COG0200	Binds to the 23S rRNA
E5E97_05875	COG0201	protein transport
E5E97_05880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E97_05885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5E97_05890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5E97_05895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5E97_05900	COG0202	RNA polymerase activity
E5E97_05905	COG0203	ribosomal protein L17
E5E97_05960	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5E97_05965	COG0583	DNA-binding transcription factor activity
E5E97_05970	COG4221	oxidoreductase activity
E5E97_05985	COG1770	oligopeptidase
E5E97_06010	COG3714	YhhN family
E5E97_06035	COG1301	dicarboxylic acid transport
E5E97_06045	COG2095	MarC family integral membrane protein
E5E97_06055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E97_06065	COG0741	lytic transglycosylase activity
E5E97_06070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E97_06095	COG0742	ribosomal rna small subunit methyltransferase
E5E97_06100	COG0552	protein localization to endoplasmic reticulum
E5E97_06105	COG2884	Cell division ATP-binding protein ftsE
E5E97_06110	COG2177	Part of the ABC transporter FtsEX involved in
E5E97_06120	COG0288	reversible hydration of carbon dioxide
E5E97_06125	COG2188	Transcriptional regulator
E5E97_06130	COG1228	amidohydrolase
E5E97_06135	COG0010	Belongs to the arginase family
E5E97_06140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5E97_06145	COG2986	histidine ammonia-lyase
E5E97_06150	COG0387	Pfam Sodium calcium exchanger
E5E97_06155	COG2200	EAL domain
E5E97_06160	COG2200	EAL domain
E5E97_06160	COG2199	diguanylate cyclase activity
E5E97_06210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E97_06215	COG1459	type II secretion system
E5E97_06230	COG4969	Belongs to the N-Me-Phe pilin family
E5E97_06235	COG4968	Prepilin-type N-terminal cleavage methylation domain
E5E97_06260	COG1077	Cell shape determining protein MreB Mrl
E5E97_06265	COG1792	Involved in formation and maintenance of cell shape
E5E97_06270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5E97_06275	COG0424	maF-like protein
E5E97_06280	COG1530	ribonuclease E activity
E5E97_06285	COG3164	Protein of unknown function
E5E97_06300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E97_06305	COG0312	modulator of DNA gyrase
E5E97_06325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_06325	COG1263	PTS System
E5E97_06330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5E97_06345	COG0477	Major facilitator Superfamily
E5E97_06355	COG3437	response regulator, receiver
E5E97_06360	COG0784	Response regulator, receiver
E5E97_06360	COG5002	protein histidine kinase activity
E5E97_06360	COG2205	protein histidine kinase activity
E5E97_06365	COG2172	sigma factor antagonist activity
E5E97_06370	COG1366	Belongs to the anti-sigma-factor antagonist family
E5E97_06390	COG3700	Belongs to the class B bacterial acid phosphatase family
E5E97_06395	COG2321	neutral zinc metallopeptidase
E5E97_06405	COG1639	'signal transduction protein
E5E97_06430	COG0189	ligase activity
E5E97_06440	COG0642	Histidine kinase
E5E97_06445	COG0745	RESPONSE REGULATOR receiver
E5E97_06460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5E97_06465	COG0352	thiamine-phosphate diphosphorylase activity
E5E97_06470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E97_06480	COG2022	thiamine diphosphate biosynthetic process
E5E97_06485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E97_06500	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E5E97_06520	COG3706	GGDEF domain
E5E97_06525	COG0814	amino acid
E5E97_06530	COG3932	Exopolysaccharide synthesis, ExoD
E5E97_06550	COG1733	regulation of RNA biosynthetic process
E5E97_06590	COG1494	fructose-1,6-bisphosphatase
E5E97_06605	COG2959	enzyme of heme biosynthesis
E5E97_06615	COG0181	hydroxymethylbilane synthase activity
E5E97_06620	COG3072	Adenylate cyclase
E5E97_06625	COG0400	carboxylic ester hydrolase activity
E5E97_06630	COG1965	Belongs to the frataxin family
E5E97_06640	COG0019	diaminopimelate decarboxylase activity
E5E97_06645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5E97_06660	COG1011	Hydrolase
E5E97_06680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5E97_06685	COG0561	phosphatase activity
E5E97_06700	COG0842	Transport permease protein
E5E97_06700	COG1129	ABC transporter
E5E97_06710	COG1546	Belongs to the CinA family
E5E97_06710	COG1058	Belongs to the CinA family
E5E97_06715	COG1418	mRNA catabolic process
E5E97_06720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5E97_06730	COG1522	sequence-specific DNA binding
E5E97_06735	COG1368	sulfuric ester hydrolase activity
E5E97_06755	COG1285	pathogenesis
E5E97_06775	COG4221	oxidoreductase activity
E5E97_06805	COG2873	o-acetylhomoserine
E5E97_06830	COG5380	lipid catabolic process
E5E97_06835	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E5E97_06850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5E97_06855	COG2949	membrane
E5E97_06860	COG3291	Pkd domain containing protein
E5E97_06870	COG3539	Fimbrial protein
E5E97_06880	COG3188	usher protein
E5E97_06885	COG3121	Chaperone
E5E97_06890	COG3539	Fimbrial protein
E5E97_06905	COG0318	PFAM AMP-dependent synthetase and ligase
E5E97_06910	COG1441	menaquinone biosynthetic process
E5E97_06915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5E97_06920	COG0596	Alpha beta hydrolase
E5E97_06925	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E5E97_06930	COG1169	isochorismate synthase
E5E97_06935	COG1575	Belongs to the MenA family. Type 1 subfamily
E5E97_06960	COG0513	Belongs to the DEAD box helicase family
E5E97_06965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E97_06970	COG1988	membrane-bound metal-dependent
E5E97_06975	COG1671	Belongs to the UPF0178 family
E5E97_07000	COG3263	regulation of cellular component size
E5E97_07005	COG3722	fumarate hydratase activity
E5E97_07010	COG0246	Mannitol dehydrogenase
E5E97_07015	COG2213	PTS system mannitol-specific
E5E97_07015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_07025	COG1309	transcriptional regulator
E5E97_07030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E5E97_07040	COG3916	Acyl-homoserine-lactone synthase
E5E97_07045	COG2771	luxR family
E5E97_07060	COG3133	Outer membrane lipoprotein
E5E97_07090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5E97_07100	COG3031	protein transport across the cell outer membrane
E5E97_07110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E97_07115	COG1459	type II secretion system
E5E97_07120	COG2165	general secretion pathway protein
E5E97_07135	COG2165	general secretion pathway protein
E5E97_07140	COG4795	General secretion pathway protein
E5E97_07150	COG3156	type II secretion system protein K
E5E97_07160	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E5E97_07175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E97_07180	COG1011	Hydrolase
E5E97_07185	COG0494	nUDIX hydrolase
E5E97_07190	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5E97_07195	COG0814	amino acid
E5E97_07200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E97_07215	COG0626	cystathionine gamma-synthase activity
E5E97_07220	COG0527	aspartate kinase activity
E5E97_07220	COG0460	homoserine dehydrogenase
E5E97_07230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5E97_07240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5E97_07245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5E97_07255	COG0137	argininosuccinate synthase activity
E5E97_07260	COG0165	Argininosuccinate lyase
E5E97_07285	COG0110	maltose O-acetyltransferase activity
E5E97_07290	COG3174	membrane
E5E97_07295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5E97_07305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5E97_07310	COG4208	sulfate ABC transporter
E5E97_07315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5E97_07320	COG0583	DNA-binding transcription factor activity
E5E97_07325	COG3397	chitin binding
E5E97_07365	COG0793	Belongs to the peptidase S41A family
E5E97_07365	COG4946	Tricorn protease homolog
E5E97_07385	COG1328	CTP reductase activity
E5E97_07390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E97_07405	COG1448	Aminotransferase
E5E97_07450	COG0513	Belongs to the DEAD box helicase family
E5E97_07470	COG0840	transmembrane signaling receptor activity
E5E97_07485	COG3112	Uncharacterised protein family (UPF0231)
E5E97_07490	COG3835	regulator
E5E97_07495	COG2610	gluconate transmembrane transporter activity
E5E97_07500	COG1929	Belongs to the glycerate kinase type-1 family
E5E97_07515	COG0583	DNA-binding transcription factor activity
E5E97_07520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E97_07525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5E97_07535	COG0347	Belongs to the P(II) protein family
E5E97_07540	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E97_07550	COG3842	ATPase activity
E5E97_07555	COG2837	iron assimilation
E5E97_07560	COG1438	arginine binding
E5E97_07565	COG1126	abc transporter atp-binding protein
E5E97_07570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_07575	COG4215	(ABC) transporter
E5E97_07580	COG4160	amino acid transport
E5E97_07585	COG0039	L-malate dehydrogenase activity
E5E97_07590	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E5E97_07595	COG1017	nitric oxide dioxygenase activity
E5E97_07595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E97_07605	COG4536	flavin adenine dinucleotide binding
E5E97_07610	COG4137	Cytochrome C assembly protein
E5E97_07615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5E97_07620	COG0228	four-way junction DNA binding
E5E97_07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5E97_07630	COG0336	Belongs to the RNA methyltransferase TrmD family
E5E97_07635	COG0335	large ribosomal subunit rRNA binding
E5E97_07645	COG3066	DNA modification
E5E97_07650	COG1051	belongs to the nudix hydrolase family
E5E97_07660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5E97_07665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5E97_07670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E97_07820	COG4695	Portal protein
E5E97_07915	COG4974	Belongs to the 'phage' integrase family
E5E97_07920	COG0583	DNA-binding transcription factor activity
E5E97_07925	COG0640	Transcriptional regulator
E5E97_07930	COG0268	Binds directly to 16S ribosomal RNA
E5E97_07935	COG0728	peptidoglycan biosynthetic process
E5E97_07940	COG0196	riboflavin kinase activity
E5E97_07945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5E97_07950	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5E97_07955	COG1047	Peptidyl-prolyl cis-trans
E5E97_07960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5E97_08020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E97_08020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5E97_08035	COG1854	S-ribosylhomocysteine lyase activity
E5E97_08040	COG3706	GGDEF domain
E5E97_08045	COG0557	exoribonuclease II activity
E5E97_08050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E97_08060	COG2153	protein acetylation
E5E97_08080	COG1914	H( )-stimulated, divalent metal cation uptake system
E5E97_08085	COG0360	Binds together with S18 to 16S ribosomal RNA
E5E97_08090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5E97_08095	COG0359	binds to the 23S rRNA
E5E97_08100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E97_08125	COG1238	metal cluster binding
E5E97_08130	COG0612	Peptidase, M16
E5E97_08135	COG2918	glutathione biosynthetic process
E5E97_08145	COG1022	Amp-dependent synthetase and ligase
E5E97_08165	COG0714	Associated with various cellular activities
E5E97_08175	COG3300	MHYT domain
E5E97_08175	COG5001	Diguanylate cyclase
E5E97_08215	COG1902	pentaerythritol trinitrate reductase activity
E5E97_08225	COG2852	Protein conserved in bacteria
E5E97_08235	COG2957	Belongs to the agmatine deiminase family
E5E97_08240	COG0154	amidase activity
E5E97_08260	COG0513	Belongs to the DEAD box helicase family
E5E97_08280	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E5E97_08310	COG2070	2-Nitropropane dioxygenase
E5E97_08350	COG2816	NAD+ diphosphatase activity
E5E97_08360	COG0745	RESPONSE REGULATOR receiver
E5E97_08365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_08370	COG0577	efflux transmembrane transporter activity
E5E97_08370	COG1136	(ABC) transporter
E5E97_08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_08380	COG1126	abc transporter atp-binding protein
E5E97_08385	COG0765	amino acid transport
E5E97_08390	COG0765	amino acid transport
E5E97_08395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E97_08400	COG1505	serine-type exopeptidase activity
E5E97_08420	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_08425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5E97_08440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E97_08445	COG4991	sh3 domain protein
E5E97_08460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5E97_08465	COG1940	carbohydrate kinase activity
E5E97_08470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E97_08475	COG0126	phosphoglycerate kinase activity
E5E97_08485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E97_08525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5E97_08535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5E97_08540	COG1595	DNA-templated transcription, initiation
E5E97_08545	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E5E97_08560	COG0481	GTPase activity
E5E97_08565	COG0681	Belongs to the peptidase S26 family
E5E97_08570	COG0571	ribonuclease III activity
E5E97_08580	COG1381	Involved in DNA repair and RecF pathway recombination
E5E97_08585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5E97_08600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E97_08605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_08610	COG3716	PTS system mannose fructose sorbose family IID component
E5E97_08620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_08625	COG2222	sugar isomerase
E5E97_08635	COG1349	DNA-binding transcription factor activity
E5E97_08645	COG4807	Protein conserved in bacteria
E5E97_08655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E97_08660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E97_08665	COG3956	TIGRFAM MazG family protein
E5E97_08670	COG0504	CTP synthase activity
E5E97_08675	COG0148	phosphopyruvate hydratase activity
E5E97_08680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5E97_08685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5E97_08695	COG0585	pseudouridine synthase activity
E5E97_08700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5E97_08705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5E97_08710	COG1238	metal cluster binding
E5E97_08725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5E97_08730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5E97_08735	COG1610	YqeY-like protein
E5E97_08740	COG0358	DNA primase activity
E5E97_08745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5E97_08770	COG0151	Belongs to the GarS family
E5E97_08775	COG0138	bifunctional purine biosynthesis protein purh
E5E97_08785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5E97_08790	COG3036	rescue of stalled ribosome
E5E97_08795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E97_08800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5E97_08810	COG0673	inositol 2-dehydrogenase activity
E5E97_08820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E97_08825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E97_08840	COG0477	Major facilitator Superfamily
E5E97_08850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E97_08855	COG1027	Aspartate ammonia-lyase
E5E97_08860	COG3030	protein affecting phage T7 exclusion by the F plasmid
E5E97_08865	COG0534	Mate efflux family protein
E5E97_08870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5E97_08875	COG0459	protein refolding
E5E97_08885	COG5001	Diguanylate cyclase
E5E97_08885	COG3300	MHYT domain
E5E97_08895	COG0564	pseudouridine synthase activity
E5E97_08900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5E97_08930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E97_08940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5E97_08945	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E5E97_08950	COG1178	ABC-type Fe3 transport system permease component
E5E97_08970	COG0066	3-isopropylmalate dehydratase activity
E5E97_08975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5E97_08980	COG0473	3-isopropylmalate dehydrogenase activity
E5E97_08985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E97_08995	COG0671	phosphoesterase, PA-phosphatase related
E5E97_09010	COG0028	Belongs to the TPP enzyme family
E5E97_09020	COG0280	phosphate acetyltransferase
E5E97_09020	COG0857	belongs to the CobB CobQ family
E5E97_09025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5E97_09035	COG3013	Belongs to the UPF0304 family
E5E97_09040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5E97_09045	COG2716	regulation of RNA biosynthetic process
E5E97_09055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E5E97_09060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5E97_09075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5E97_09095	COG0784	Response regulator, receiver
E5E97_09095	COG2198	Histidine kinase
E5E97_09095	COG5002	protein histidine kinase activity
E5E97_09120	COG0840	transmembrane signaling receptor activity
E5E97_09135	COG1464	Belongs to the NlpA lipoprotein family
E5E97_09140	COG2011	ABC-type metal ion transport system permease component
E5E97_09145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5E97_09165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5E97_09165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5E97_09170	COG0802	atpase or kinase
E5E97_09180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5E97_09185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5E97_09190	COG1923	regulation of RNA biosynthetic process
E5E97_09195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5E97_09200	COG0330	HflC and HflK could
E5E97_09205	COG0330	HflC and HflK could
E5E97_09210	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E5E97_09215	COG0142	geranyltranstransferase activity
E5E97_09220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5E97_09225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5E97_09230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5E97_09240	COG0318	PFAM AMP-dependent synthetase and ligase
E5E97_09255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E97_09260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5E97_09270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5E97_09275	COG2967	ApaG domain
E5E97_09280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5E97_09285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5E97_09295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5E97_09300	COG3178	'Phosphotransferase
E5E97_09305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5E97_09310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E97_09315	COG2252	PERMEase
E5E97_09325	COG0488	(ABC) transporter
E5E97_09340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E97_09345	COG0741	lytic transglycosylase activity
E5E97_09365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5E97_09370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E97_09375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E97_09400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E97_09410	COG3721	Heme iron utilization protein
E5E97_09415	COG0748	coenzyme F420 binding
E5E97_09435	COG4771	TonB-dependent receptor
E5E97_09440	COG2814	Major facilitator Superfamily
E5E97_09445	COG3655	Transcriptional regulator
E5E97_09455	COG2205	protein histidine kinase activity
E5E97_09455	COG2202	Pas domain
E5E97_09470	COG3397	chitin binding
E5E97_09485	COG1765	OsmC-like protein
E5E97_09500	COG3954	Phosphoribulokinase
E5E97_09505	COG2076	Multidrug Resistance protein
E5E97_09510	COG2076	Multidrug Resistance protein
E5E97_09515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5E97_09520	COG0726	polysaccharide deacetylase
E5E97_09525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E97_09525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E97_09530	COG0463	Glycosyl transferase, family 2
E5E97_09535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E97_09545	COG3089	Belongs to the UPF0270 family
E5E97_09550	COG4251	negative regulation of phosphorylation
E5E97_09550	COG5001	Diguanylate cyclase
E5E97_09550	COG2203	Gaf domain
E5E97_09550	COG3706	GGDEF domain
E5E97_09555	COG0429	hydrolase of the alpha beta-hydrolase fold
E5E97_09560	COG0835	chemotaxis
E5E97_09560	COG0784	Response regulator, receiver
E5E97_09570	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5E97_09575	COG1047	Peptidyl-prolyl cis-trans
E5E97_09590	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E97_09595	COG2204	response regulator
E5E97_09615	COG0737	Belongs to the 5'-nucleotidase family
E5E97_09620	COG2200	EAL domain
E5E97_09635	COG0305	Participates in initiation and elongation during chromosome replication
E5E97_09645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E97_09655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_09665	COG2203	Gaf domain
E5E97_09665	COG2200	EAL domain
E5E97_09665	COG2199	diguanylate cyclase activity
E5E97_09690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E97_09695	COG2201	protein-glutamate methylesterase activity
E5E97_09700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5E97_09710	COG0840	transmembrane signaling receptor activity
E5E97_09715	COG0835	chemotaxis
E5E97_09725	COG2198	Histidine kinase
E5E97_09725	COG0643	Histidine kinase
E5E97_09740	COG0840	transmembrane signaling receptor activity
E5E97_09760	COG0826	peptidase U32
E5E97_09785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E5E97_09810	COG0300	oxidoreductase activity
E5E97_09820	COG0840	transmembrane signaling receptor activity
E5E97_09830	COG0235	Class ii aldolase
E5E97_09835	COG1454	alcohol dehydrogenase
E5E97_09840	COG4977	sequence-specific DNA binding
E5E97_09845	COG1070	Carbohydrate kinase
E5E97_09850	COG4806	L-rhamnose isomerase
E5E97_09860	COG3254	rhamnose metabolic process
E5E97_09895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E97_09905	COG4584	PFAM Integrase catalytic
E5E97_09910	COG1484	DNA-dependent DNA replication
E5E97_09965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_09970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5E97_09975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_09985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_09990	COG3706	GGDEF domain
E5E97_10015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_10020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_10025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_10045	COG5433	transposase activity
E5E97_10080	COG1605	Chorismate mutase
E5E97_10080	COG0077	Prephenate dehydratase
E5E97_10110	COG3272	Protein of unknown function (DUF1722)
E5E97_10115	COG0789	Transcriptional regulator
E5E97_10120	COG0415	Belongs to the DNA photolyase family
E5E97_10130	COG4221	oxidoreductase activity
E5E97_10170	COG0783	Belongs to the Dps family
E5E97_10175	COG1151	hydroxylamine reductase activity
E5E97_10185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E97_10190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E97_10190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E97_10210	COG2771	luxR family
E5E97_10225	COG3501	Rhs element vgr protein
E5E97_10260	COG0693	protein deglycase activity
E5E97_10265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5E97_10270	COG1666	GTP binding
E5E97_10275	COG3248	Nucleoside-binding outer membrane protein
E5E97_10280	COG2211	Major facilitator Superfamily
E5E97_10290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E97_10300	COG2813	Specifically methylates the guanine in position
E5E97_10305	COG0271	Belongs to the BolA IbaG family
E5E97_10310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E97_10315	COG1805	sodium ion transport
E5E97_10320	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E97_10325	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E97_10330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E97_10335	COG2871	sodium ion transport
E5E97_10340	COG1477	protein flavinylation
E5E97_10355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5E97_10360	COG0840	transmembrane signaling receptor activity
E5E97_10365	COG0583	DNA-binding transcription factor activity
E5E97_10375	COG2363	Small membrane protein
E5E97_10380	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E5E97_10390	COG0473	3-isopropylmalate dehydrogenase activity
E5E97_10395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E97_10400	COG1611	Belongs to the LOG family
E5E97_10405	COG3706	GGDEF domain
E5E97_10415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E97_10415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E97_10425	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E5E97_10450	COG3098	single-species biofilm formation
E5E97_10455	COG0564	pseudouridine synthase activity
E5E97_10465	COG4580	involved in the transport of maltose and maltodextrins
E5E97_10475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_10475	COG1263	PTS System
E5E97_10485	COG2171	N-acyltransferase activity
E5E97_10490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5E97_10495	COG0024	Methionine aminopeptidase
E5E97_10500	COG0052	Belongs to the universal ribosomal protein uS2 family
E5E97_10505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5E97_10510	COG0528	UMP kinase activity
E5E97_10515	COG0233	cytoplasmic translational termination
E5E97_10520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5E97_10525	COG0575	Belongs to the CDS family
E5E97_10530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5E97_10535	COG0750	zinc metalloprotease
E5E97_10550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E97_10555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E97_10560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E97_10565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E97_10570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5E97_10580	COG0825	malonyl-CoA metabolic process
E5E97_10585	COG3710	Transcriptional regulator
E5E97_10590	COG0531	amino acid
E5E97_10595	COG1982	Orn Lys Arg decarboxylase major
E5E97_10600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E97_10615	COG0814	amino acid
E5E97_10620	COG1234	tRNA 3'-trailer cleavage
E5E97_10630	COG1073	alpha beta
E5E97_10635	COG1073	alpha beta
E5E97_10645	COG0531	amino acid
E5E97_10655	COG0488	(ABC) transporter
E5E97_10665	COG3590	peptidase
E5E97_10675	COG3706	GGDEF domain
E5E97_10710	COG0366	Alpha amylase catalytic
E5E97_10725	COG0463	Glycosyl transferase, family 2
E5E97_10740	COG2989	Protein conserved in bacteria
E5E97_10745	COG3108	Peptidase M15
E5E97_10755	COG2860	membrane
E5E97_10765	COG1196	nuclear chromosome segregation
E5E97_10770	COG3115	cell septum assembly
E5E97_10775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5E97_10785	COG1328	CTP reductase activity
E5E97_10790	COG0602	queuosine metabolic process
E5E97_10820	COG1566	PFAM secretion protein HlyD family protein
E5E97_10855	COG0697	spore germination
E5E97_10865	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_10870	COG3284	Transcriptional regulator
E5E97_10875	COG1960	acyl-CoA dehydrogenase activity
E5E97_10880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5E97_10885	COG0346	lactoylglutathione lyase activity
E5E97_10890	COG0745	RESPONSE REGULATOR receiver
E5E97_10895	COG5002	protein histidine kinase activity
E5E97_10920	COG3142	Participates in the control of copper homeostasis
E5E97_10925	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E97_10930	COG1131	(ABC) transporter
E5E97_10950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5E97_10970	COG0019	diaminopimelate decarboxylase activity
E5E97_10975	COG1115	amino acid carrier protein
E5E97_10980	COG0095	Lipoate-protein ligase
E5E97_10985	COG2233	PERMEase
E5E97_11000	COG0534	Mate efflux family protein
E5E97_11010	COG0281	malic enzyme
E5E97_11040	COG0733	neurotransmitter:sodium symporter activity
E5E97_11045	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5E97_11050	COG2203	Gaf domain
E5E97_11050	COG2199	diguanylate cyclase activity
E5E97_11055	COG1566	PFAM secretion protein HlyD family protein
E5E97_11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E97_11070	COG1032	radical SAM domain protein
E5E97_11105	COG0673	inositol 2-dehydrogenase activity
E5E97_11115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5E97_11120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E97_11125	COG0741	lytic transglycosylase activity
E5E97_11125	COG0739	heme binding
E5E97_11125	COG1196	nuclear chromosome segregation
E5E97_11130	COG0366	Alpha amylase catalytic
E5E97_11150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E97_11160	COG0788	formyltetrahydrofolate deformylase activity
E5E97_11165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E97_11175	COG3118	belongs to the thioredoxin family
E5E97_11185	COG0791	NLP P60 protein
E5E97_11190	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E5E97_11250	COG3561	AntA/AntB antirepressor
E5E97_11270	COG0582	viral genome integration into host DNA
E5E97_11290	COG4869	propanediol catabolic process
E5E97_11300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E97_11305	COG1882	Formate acetyltransferase
E5E97_11310	COG1454	alcohol dehydrogenase
E5E97_11310	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_11320	COG1454	alcohol dehydrogenase
E5E97_11320	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_11355	COG0583	DNA-binding transcription factor activity
E5E97_11360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E97_11365	COG0243	molybdopterin cofactor binding
E5E97_11375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5E97_11385	COG1960	acyl-CoA dehydrogenase activity
E5E97_11390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E97_11400	COG0469	pyruvate kinase activity
E5E97_11405	COG1737	Transcriptional regulator
E5E97_11420	COG0745	RESPONSE REGULATOR receiver
E5E97_11425	COG2274	protein secretion by the type I secretion system
E5E97_11435	COG2274	protein secretion by the type I secretion system
E5E97_11445	COG2994	toxin metabolic process
E5E97_11450	COG1073	alpha beta
E5E97_11450	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E5E97_11450	COG3064	Membrane
E5E97_11460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E97_11465	COG3039	Transposase
E5E97_11470	COG3447	MASE1 domain protein
E5E97_11470	COG5001	Diguanylate cyclase
E5E97_11470	COG5002	protein histidine kinase activity
E5E97_11575	COG0789	Transcriptional regulator
E5E97_11585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5E97_11620	COG0789	Transcriptional regulator
E5E97_11635	COG5642	Protein of unknown function (DUF2384)
E5E97_11650	COG3385	transposase activity
E5E97_11675	COG2194	sulfuric ester hydrolase activity
E5E97_11755	COG1677	Flagellar hook-basal body complex protein FliE
E5E97_11765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5E97_11820	COG1684	flagellar biosynthetic protein fliR
E5E97_11830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5E97_11855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E5E97_11860	COG0784	Response regulator, receiver
E5E97_11860	COG0643	Histidine kinase
E5E97_11860	COG2198	Histidine kinase
E5E97_11865	COG2201	protein-glutamate methylesterase activity
E5E97_11870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E97_11875	COG1360	Flagellar Motor Protein
E5E97_11880	COG1192	Involved in chromosome partitioning
E5E97_11890	COG0835	chemotaxis
E5E97_11905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E97_11910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E97_11915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E97_11920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5E97_11925	COG1138	Cytochrome C-type biogenesis protein
E5E97_11930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E97_11935	COG3088	subunit of a heme lyase
E5E97_11935	COG4235	cytochrome complex assembly
E5E97_11940	COG4235	cytochrome complex assembly
E5E97_11940	COG3088	subunit of a heme lyase
E5E97_11955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5E97_11960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E97_11960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E97_11975	COG0259	pyridoxamine-phosphate oxidase activity
E5E97_11980	COG0625	glutathione transferase activity
E5E97_11990	COG3153	acetyltransferase
E5E97_12000	COG2850	peptidyl-arginine hydroxylation
E5E97_12005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5E97_12010	COG2915	High frequency lysogenization protein hflD homolog
E5E97_12015	COG0482	sulfurtransferase activity
E5E97_12025	COG1187	pseudouridine synthase activity
E5E97_12035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_12045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_12045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_12045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_12055	COG0456	acetyltransferase
E5E97_12065	COG0789	Transcriptional regulator
E5E97_12075	COG1609	Transcriptional regulator
E5E97_12080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_12080	COG1263	PTS System
E5E97_12085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E97_12100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_12120	COG2207	Transcriptional regulator
E5E97_12125	COG0538	isocitrate dehydrogenase activity
E5E97_12140	COG3048	D-serine ammonia-lyase activity
E5E97_12150	COG0583	DNA-binding transcription factor activity
E5E97_12155	COG1940	carbohydrate kinase activity
E5E97_12205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5E97_12250	COG0464	growth
E5E97_12310	COG0653	protein targeting
E5E97_12330	COG2003	Belongs to the UPF0758 family
E5E97_12355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5E97_12360	COG2867	negative regulation of translational initiation
E5E97_12370	COG0702	epimerase
E5E97_12375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E97_12380	COG1454	alcohol dehydrogenase
E5E97_12390	COG0564	pseudouridine synthase activity
E5E97_12395	COG1957	nucleoside hydrolase
E5E97_12420	COG1280	lysine exporter protein (LysE YggA)
E5E97_12430	COG3263	regulation of cellular component size
E5E97_12450	COG1876	peptidase activity
E5E97_12455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E97_12460	COG1393	Belongs to the ArsC family
E5E97_12465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5E97_12475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5E97_12485	COG0583	DNA-binding transcription factor activity
E5E97_12495	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E97_12510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E97_12515	COG0017	Asparaginyl-tRNA synthetase
E5E97_12535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E97_12540	COG0156	8-amino-7-oxononanoate synthase activity
E5E97_12545	COG2226	methyltransferase
E5E97_12545	COG1073	alpha beta
E5E97_12550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5E97_12555	COG0501	Belongs to the peptidase M48B family
E5E97_12565	COG3217	Mosc domain protein beta barrel domain protein
E5E97_12565	COG0633	Ferredoxin
E5E97_12565	COG3217	Mosc domain protein beta barrel domain protein
E5E97_12565	COG0633	Ferredoxin
E5E97_12575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5E97_12575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5E97_12575	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5E97_12575	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5E97_12595	COG0534	Mate efflux family protein
E5E97_12635	COG1309	transcriptional regulator
E5E97_12650	COG0791	NLP P60 protein
E5E97_12660	COG0583	DNA-binding transcription factor activity
E5E97_12665	COG0450	alkyl hydroperoxide reductase
E5E97_12685	COG0500	methyltransferase
E5E97_12690	COG4106	trans-aconitate 2-methyltransferase activity
E5E97_12695	COG1801	Protein of unknown function DUF72
E5E97_12700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5E97_12705	COG0217	transcriptional regulatory protein
E5E97_12710	COG2194	sulfuric ester hydrolase activity
E5E97_12715	COG1940	carbohydrate kinase activity
E5E97_12715	COG1846	Transcriptional regulator
E5E97_12720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E97_12725	COG0363	glucosamine-6-phosphate deaminase activity
E5E97_12730	COG1263	PTS System
E5E97_12730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_12730	COG2190	(PTS) system
E5E97_12740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E97_12745	COG0735	belongs to the Fur family
E5E97_12755	COG0716	FMN binding
E5E97_12770	COG0596	Alpha beta hydrolase
E5E97_12775	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E5E97_12780	COG0033	Phosphoglucomutase
E5E97_12790	COG1846	Transcriptional regulator
E5E97_12805	COG2951	lytic endotransglycosylase activity
E5E97_12810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5E97_12815	COG4136	ATPase activity
E5E97_12825	COG4134	Bacterial extracellular solute-binding protein
E5E97_12835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E97_12845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_12850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E97_12860	COG0729	surface antigen
E5E97_12885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5E97_12895	COG0741	lytic transglycosylase activity
E5E97_12910	COG1607	acyl-coa hydrolase
E5E97_12920	COG3021	interspecies interaction between organisms
E5E97_12925	COG0741	lytic transglycosylase activity
E5E97_12925	COG1388	LysM domain
E5E97_12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E97_12935	COG2226	methyltransferase
E5E97_12940	COG0328	RNA-DNA hybrid ribonuclease activity
E5E97_12955	COG0784	Response regulator, receiver
E5E97_12955	COG3437	response regulator, receiver
E5E97_12960	COG1960	acyl-CoA dehydrogenase activity
E5E97_12965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E97_12970	COG0121	glutamine amidotransferase
E5E97_13000	COG2197	response regulator
E5E97_13005	COG3850	Histidine kinase
E5E97_13010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5E97_13015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_13015	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_13025	COG0243	molybdopterin cofactor binding
E5E97_13030	COG0437	4 iron, 4 sulfur cluster binding
E5E97_13035	COG0348	domain, Protein
E5E97_13045	COG3005	denitrification pathway
E5E97_13050	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E97_13055	COG0315	cyclic pyranopterin monophosphate synthase activity
E5E97_13060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E5E97_13065	COG0314	molybdopterin synthase activity
E5E97_13080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5E97_13085	COG2267	carboxylic ester hydrolase activity
E5E97_13090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E97_13100	COG0302	gtp cyclohydrolase
E5E97_13105	COG0840	transmembrane signaling receptor activity
E5E97_13110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5E97_13115	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5E97_13125	COG0583	DNA-binding transcription factor activity
E5E97_13155	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E97_13175	COG1166	arginine decarboxylase activity
E5E97_13205	COG3681	Belongs to the UPF0597 family
E5E97_13220	COG1403	HNH endonuclease
E5E97_13230	COG0346	lactoylglutathione lyase activity
E5E97_13250	COG1187	pseudouridine synthase activity
E5E97_13260	COG2807	transmembrane transport
E5E97_13275	COG2271	Major facilitator Superfamily
E5E97_13300	COG2979	Protein of unknown function (DUF533)
E5E97_13315	COG1271	oxidase subunit
E5E97_13320	COG1294	oxidase, subunit
E5E97_13330	COG2814	Major facilitator Superfamily
E5E97_13335	COG0656	L-ascorbic acid biosynthetic process
E5E97_13355	COG0583	DNA-binding transcription factor activity
E5E97_13360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5E97_13365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E97_13370	COG2271	Major facilitator Superfamily
E5E97_13375	COG1349	DNA-binding transcription factor activity
E5E97_13385	COG0584	glycerophosphoryl diester phosphodiesterase
E5E97_13390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E97_13395	COG1605	Chorismate mutase
E5E97_13395	COG0287	Prephenate dehydrogenase
E5E97_13400	COG0583	DNA-binding transcription factor activity
E5E97_13405	COG3085	chromosome segregation
E5E97_13410	COG4574	serine-type endopeptidase inhibitor activity
E5E97_13430	COG1770	oligopeptidase
E5E97_13435	COG4771	TonB-dependent receptor
E5E97_13440	COG3083	sulfuric ester hydrolase activity
E5E97_13445	COG3082	Protein of unknown function (DUF1414)
E5E97_13450	COG3081	Nucleoid-associated protein
E5E97_13460	COG1175	transmembrane transport
E5E97_13465	COG3833	ABC-type maltose transport systems, permease component
E5E97_13470	COG3842	ATPase activity
E5E97_13495	COG0425	Belongs to the sulfur carrier protein TusA family
E5E97_13500	COG4783	chaperone-mediated protein folding
E5E97_13510	COG1393	Belongs to the ArsC family
E5E97_13525	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E5E97_13530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E97_13535	COG2431	L-lysine efflux transmembrane transporter activity
E5E97_13545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_13575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5E97_13575	COG1215	transferase activity, transferring glycosyl groups
E5E97_13580	COG1215	transferase activity, transferring glycosyl groups
E5E97_13580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5E97_13590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5E97_13625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E97_13635	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E97_13655	COG1538	Outer membrane efflux protein
E5E97_13665	COG1473	amidohydrolase
E5E97_13670	COG2373	Large extracellular alpha-helical protein
E5E97_13675	COG4953	penicillin-binding protein 1C
E5E97_13685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E97_13685	COG0301	tRNA thio-modification
E5E97_13700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E97_13705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E97_13745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E97_13765	COG0483	inositol monophosphate 1-phosphatase activity
E5E97_13775	COG0625	glutathione transferase activity
E5E97_13780	COG2814	Major facilitator Superfamily
E5E97_13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E97_13805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E97_13810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5E97_13815	COG0509	glycine decarboxylation via glycine cleavage system
E5E97_13820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E97_13820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E97_13850	COG0798	PFAM Bile acid sodium symporter
E5E97_13855	COG1393	Belongs to the ArsC family
E5E97_13875	COG3634	alkyl hydroperoxide reductase activity
E5E97_13885	COG0517	IMP dehydrogenase activity
E5E97_13890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5E97_13895	COG0343	queuine tRNA-ribosyltransferase activity
E5E97_13900	COG1862	Preprotein translocase
E5E97_13905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E97_13910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E97_13915	COG2897	thiosulfate sulfurtransferase activity
E5E97_13925	COG0826	peptidase U32
E5E97_13930	COG0826	peptidase U32
E5E97_13935	COG3154	lipid carrier protein
E5E97_13955	COG1104	cysteine desulfurase activity
E5E97_13960	COG0822	iron-sulfur transferase activity
E5E97_13970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E97_13975	COG0443	Heat shock 70 kDa protein
E5E97_13980	COG0633	Ferredoxin
E5E97_13990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E97_13995	COG0105	UTP biosynthetic process
E5E97_14000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5E97_14015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5E97_14020	COG0124	histidyl-tRNA synthetase
E5E97_14025	COG2976	Protein conserved in bacteria
E5E97_14030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E97_14035	COG1160	GTP binding
E5E97_14040	COG1645	bacterial-type flagellum-dependent swarming motility
E5E97_14050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5E97_14055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5E97_14055	COG0047	phosphoribosylformylglycinamidine synthase activity
E5E97_14060	COG2199	diguanylate cyclase activity
E5E97_14060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E97_14075	COG1007	ATP synthesis coupled electron transport
E5E97_14080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_14090	COG0713	ATP synthesis coupled electron transport
E5E97_14095	COG0839	Belongs to the complex I subunit 6 family
E5E97_14100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_14105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5E97_14110	COG1034	ATP synthesis coupled electron transport
E5E97_14125	COG0649	NAD binding
E5E97_14125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_14130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_14135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_14140	COG1360	Flagellar Motor Protein
E5E97_14145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E97_14165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5E97_14185	COG0724	RNA recognition motif
E5E97_14190	COG4989	oxidoreductase activity
E5E97_14215	COG3437	response regulator, receiver
E5E97_14220	COG0583	DNA-binding transcription factor activity
E5E97_14230	COG5001	Diguanylate cyclase
E5E97_14230	COG3300	MHYT domain
E5E97_14235	COG0778	Nitroreductase
E5E97_14255	COG0583	DNA-binding transcription factor activity
E5E97_14265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E97_14270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5E97_14275	COG0539	negative regulation of cytoplasmic translation
E5E97_14280	COG0776	regulation of translation
E5E97_14290	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5E97_14310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5E97_14315	COG0602	queuosine metabolic process
E5E97_14320	COG3530	Putative quorum-sensing-regulated virulence factor
E5E97_14325	COG2096	Adenosyltransferase
E5E97_14330	COG2916	Histone family protein nucleoid-structuring protein H-NS
E5E97_14335	COG1757	Na H antiporter
E5E97_14340	COG1435	thymidine kinase activity
E5E97_14365	COG3501	Rhs element vgr protein
E5E97_14470	COG3501	Rhs element vgr protein
E5E97_14475	COG3266	domain, Protein
E5E97_14475	COG4193	domain, Protein
E5E97_14475	COG5632	N-Acetylmuramoyl-L-alanine amidase
E5E97_14500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5E97_14505	COG1278	Cold shock
E5E97_14510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5E97_14515	COG0542	response to heat
E5E97_14520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5E97_14525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5E97_14530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5E97_14535	COG3134	Outer membrane lipoprotein
E5E97_14540	COG3706	GGDEF domain
E5E97_14545	COG0492	ferredoxin-NADP+ reductase activity
E5E97_14550	COG0686	Belongs to the AlaDH PNT family
E5E97_14560	COG0531	amino acid
E5E97_14560	COG1674	ftsk spoiiie
E5E97_14565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5E97_14570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5E97_14575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5E97_14580	COG1286	toxin biosynthetic process
E5E97_14585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5E97_14595	COG4172	Belongs to the ABC transporter superfamily
E5E97_14605	COG4171	peptide transport system, permease
E5E97_14610	COG4168	peptide transport system, permease
E5E97_14620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E5E97_14625	COG1842	Phage shock protein A
E5E97_14640	COG3106	COG3106 Predicted ATPase
E5E97_14645	COG3768	UPF0283 membrane protein
E5E97_14655	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5E97_14680	COG2885	chlorophyll binding
E5E97_14685	COG0861	Integral membrane protein TerC family
E5E97_14700	COG1022	Amp-dependent synthetase and ligase
E5E97_14705	COG0295	cytidine deaminase activity
E5E97_14710	COG1346	cytolysis
E5E97_14715	COG1380	Effector of murein hydrolase LrgA
E5E97_14720	COG3345	alpha-galactosidase
E5E97_14730	COG2925	Exonuclease
E5E97_14735	COG2160	L-arabinose isomerase activity
E5E97_14745	COG1069	ribulokinase activity
E5E97_14750	COG1879	ABC-type sugar transport system periplasmic component
E5E97_14760	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E97_14770	COG0583	DNA-binding transcription factor activity
E5E97_14780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E97_14785	COG0254	rRNA binding
E5E97_14800	COG1451	nucleotide metabolic process
E5E97_14815	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E97_14825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E97_14825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5E97_14830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E97_14855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5E97_14860	COG1053	succinate dehydrogenase
E5E97_14870	COG0567	Dehydrogenase, E1 component
E5E97_14875	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E97_14880	COG0045	succinate-CoA ligase (ADP-forming) activity
E5E97_14885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5E97_14900	COG2983	Belongs to the UPF0260 family
E5E97_14905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E97_14915	COG3842	ATPase activity
E5E97_14920	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E97_14930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5E97_14940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E97_14945	COG1882	Formate acetyltransferase
E5E97_14950	COG2116	formate transmembrane transporter activity
E5E97_14955	COG1944	ATP diphosphatase activity
E5E97_14965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E97_14970	COG0612	Peptidase, M16
E5E97_14985	COG2910	NAD(P)H-binding
E5E97_14990	COG0583	DNA-binding transcription factor activity
E5E97_15005	COG4774	siderophore transport
E5E97_15020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5E97_15045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E97_15050	COG3046	protein related to deoxyribodipyrimidine photolyase
E5E97_15060	COG3033	Beta-eliminating lyase
E5E97_15070	COG1051	belongs to the nudix hydrolase family
E5E97_15075	COG3088	subunit of a heme lyase
E5E97_15075	COG4235	cytochrome complex assembly
E5E97_15080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E97_15085	COG1138	Cytochrome C-type biogenesis protein
E5E97_15090	COG3301	Polysulphide reductase, NrfD
E5E97_15095	COG0437	4 iron, 4 sulfur cluster binding
E5E97_15100	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E97_15120	COG0247	lactate metabolic process
E5E97_15125	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E5E97_15130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5E97_15135	COG3012	SEC-C Motif Domain Protein
E5E97_15140	COG0840	transmembrane signaling receptor activity
E5E97_15145	COG1846	Transcriptional regulator
E5E97_15145	COG1940	carbohydrate kinase activity
E5E97_15150	COG3290	protein histidine kinase activity
E5E97_15155	COG4565	transcriptional regulatory protein
E5E97_15175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5E97_15180	COG2985	domain, Protein
E5E97_15180	COG0569	domain protein
E5E97_15195	COG0556	nucleotide-excision repair
E5E97_15205	COG0586	Pfam SNARE associated Golgi protein
E5E97_15210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5E97_15215	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E97_15220	COG2186	Transcriptional regulator
E5E97_15225	COG2719	SpoVR family
E5E97_15235	COG2766	serine protein kinase
E5E97_15240	COG0514	ATP-dependent DNA helicase (RecQ)
E5E97_15245	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E5E97_15250	COG0814	amino acid
E5E97_15285	COG0058	SHG alpha-glucan phosphorylase activity
E5E97_15290	COG0471	metal ion transport
E5E97_15295	COG3118	belongs to the thioredoxin family
E5E97_15305	COG1132	(ABC) transporter
E5E97_15315	COG1132	(ABC) transporter
E5E97_15330	COG2501	S4 domain
E5E97_15340	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5E97_15360	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E97_15365	COG2329	Antibiotic biosynthesis monooxygenase
E5E97_15395	COG1742	UPF0060 membrane protein
E5E97_15405	COG0456	acetyltransferase
E5E97_15410	COG0513	Belongs to the DEAD box helicase family
E5E97_15415	COG0386	Belongs to the glutathione peroxidase family
E5E97_15425	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5E97_15440	COG0730	response to heat
E5E97_15445	COG0583	DNA-binding transcription factor activity
E5E97_15460	COG3593	DNA synthesis involved in DNA repair
E5E97_15515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E97_15520	COG1011	Hydrolase
E5E97_15525	COG1473	amidohydrolase
E5E97_15530	COG0205	6-phosphofructokinase activity
E5E97_15540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E5E97_15545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E97_15555	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E5E97_15560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E5E97_15580	COG0242	peptide deformylase activity
E5E97_15610	COG0384	phenazine biosynthesis protein PhzF
E5E97_15625	COG2824	Alkylphosphonate utilization operon protein PhnA
E5E97_15660	COG3706	GGDEF domain
E5E97_15670	COG2840	Smr protein MutS2
E5E97_15675	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E97_15680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5E97_15690	COG0513	Belongs to the DEAD box helicase family
E5E97_15695	COG5654	RES domain protein
E5E97_15705	COG0814	amino acid
E5E97_15710	COG1609	Transcriptional regulator
E5E97_15715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_15715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_15720	COG1105	Belongs to the carbohydrate kinase PfkB family
E5E97_15725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_15725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E97_15725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E5E97_15730	COG2140	Oxalate decarboxylase
E5E97_15735	COG1609	Transcriptional regulator
E5E97_15750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_15750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_15755	COG3715	PTS system
E5E97_15760	COG3716	PTS system mannose fructose sorbose family IID component
E5E97_15765	COG2942	2-epimerase
E5E97_15770	COG3313	Fe-S protein
E5E97_15775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E5E97_15780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E97_15785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E97_15790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E97_15800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E97_15820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5E97_15825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5E97_15830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5E97_15835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5E97_15840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5E97_15845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E97_15845	COG0072	phenylalanine-tRNA ligase activity
E5E97_15850	COG0776	regulation of translation
E5E97_15855	COG2205	protein histidine kinase activity
E5E97_15855	COG0784	Response regulator, receiver
E5E97_15880	COG2199	diguanylate cyclase activity
E5E97_15885	COG1609	Transcriptional regulator
E5E97_15890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E97_15895	COG1879	ABC-type sugar transport system periplasmic component
E5E97_15900	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E97_15905	COG1129	ABC transporter
E5E97_15910	COG1869	D-ribose catabolic process
E5E97_15930	COG0037	tRNA processing
E5E97_15935	COG0589	response to stress
E5E97_15940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E97_15965	COG2010	Cytochrome c
E5E97_15980	COG3278	Belongs to the heme-copper respiratory oxidase family
E5E97_15990	COG1956	GAF domain-containing protein
E5E97_15995	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E5E97_16005	COG0308	aminopeptidase N
E5E97_16015	COG2902	Dehydrogenase
E5E97_16020	COG0167	dihydroorotate dehydrogenase activity
E5E97_16035	COG0116	Belongs to the methyltransferase superfamily
E5E97_16035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5E97_16045	COG0488	(ABC) transporter
E5E97_16060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E97_16065	COG1067	ATP-dependent peptidase activity
E5E97_16085	COG4128	Pfam Zonular occludens toxin
E5E97_16120	COG3620	sequence-specific DNA binding
E5E97_16140	COG4128	Pfam Zonular occludens toxin
E5E97_16175	COG3620	sequence-specific DNA binding
E5E97_16195	COG4128	Pfam Zonular occludens toxin
E5E97_16225	COG4584	PFAM Integrase catalytic
E5E97_16230	COG1484	DNA-dependent DNA replication
E5E97_16245	COG3620	sequence-specific DNA binding
E5E97_16255	COG3141	response to X-ray
E5E97_16310	COG0372	Belongs to the citrate synthase family
E5E97_16315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E5E97_16325	COG2995	paraquat-inducible protein a
E5E97_16330	COG3008	intermembrane lipid transfer
E5E97_16335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E97_16335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5E97_16350	COG0084	hydrolase, TatD family'
E5E97_16355	COG0470	DNA polymerase III
E5E97_16360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5E97_16365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5E97_16370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5E97_16380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E97_16385	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_16395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5E97_16400	COG0416	fatty acid biosynthetic process
E5E97_16405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5E97_16410	COG1399	metal-binding, possibly nucleic acid-binding protein
E5E97_16425	COG2814	Major facilitator Superfamily
E5E97_16430	COG0424	maF-like protein
E5E97_16435	COG0546	phosphoglycolate phosphatase activity
E5E97_16445	COG1530	ribonuclease E activity
E5E97_16450	COG0306	phosphate transporter
E5E97_16460	COG0717	Belongs to the dCTP deaminase family
E5E97_16465	COG0572	uridine kinase
E5E97_16470	COG0489	protein tyrosine kinase activity
E5E97_16475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E97_16475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E97_16485	COG0625	glutathione transferase activity
E5E97_16490	COG1254	Belongs to the acylphosphatase family
E5E97_16495	COG0840	transmembrane signaling receptor activity
E5E97_16500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5E97_16515	COG0709	Synthesizes selenophosphate from selenide and ATP
E5E97_16520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E5E97_16525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E97_16530	COG3437	response regulator, receiver
E5E97_16540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5E97_16550	COG1643	Atp-dependent helicase
E5E97_16555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5E97_16555	COG0617	tRNA 3'-terminal CCA addition
E5E97_16555	COG0517	IMP dehydrogenase activity
E5E97_16575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5E97_16585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5E97_16590	COG2832	Protein of unknown function (DUF454)
E5E97_16595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E97_16610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5E97_16615	COG0318	PFAM AMP-dependent synthetase and ligase
E5E97_16620	COG2226	methyltransferase
E5E97_16620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5E97_16620	COG0596	Alpha beta hydrolase
E5E97_16630	COG1214	PFAM Peptidase M22, glycoprotease
E5E97_16640	COG1199	ATP-dependent helicase activity
E5E97_16650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5E97_16655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5E97_16660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5E97_16665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E97_16665	COG0131	Imidazoleglycerol-phosphate dehydratase
E5E97_16670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5E97_16675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5E97_16680	COG3437	response regulator, receiver
E5E97_16690	COG2205	protein histidine kinase activity
E5E97_16690	COG0784	Response regulator, receiver
E5E97_16690	COG2198	Histidine kinase
E5E97_16695	COG0107	imidazoleglycerol-phosphate synthase activity
E5E97_16700	COG0140	phosphoribosyl-ATP diphosphatase activity
E5E97_16700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5E97_16710	COG0318	PFAM AMP-dependent synthetase and ligase
E5E97_16715	COG1288	antiporter activity
E5E97_16725	COG3134	Outer membrane lipoprotein
E5E97_16735	COG2080	2 iron, 2 sulfur cluster binding
E5E97_16740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5E97_16745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5E97_16750	COG2252	PERMEase
E5E97_16755	COG0402	S-adenosylhomocysteine deaminase activity
E5E97_16760	COG2233	PERMEase
E5E97_16765	COG2080	2 iron, 2 sulfur cluster binding
E5E97_16765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5E97_16770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5E97_16775	COG0402	S-adenosylhomocysteine deaminase activity
E5E97_16780	COG0493	'glutamate synthase
E5E97_16780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_16785	COG2068	MobA-Related Protein
E5E97_16790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5E97_16795	COG3608	succinylglutamate desuccinylase aspartoacylase
E5E97_16795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5E97_16800	COG0697	spore germination
E5E97_16805	COG0549	Belongs to the carbamate kinase family
E5E97_16815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E97_16825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E97_16875	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E97_16875	COG1024	Enoyl-CoA hydratase
E5E97_16880	COG0183	Belongs to the thiolase family
E5E97_16885	COG0714	Associated with various cellular activities
E5E97_16915	COG1595	DNA-templated transcription, initiation
E5E97_16930	COG2067	long-chain fatty acid transport protein
E5E97_16935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E5E97_16955	COG3123	guanosine phosphorylase activity
E5E97_16960	COG1760	l-serine dehydratase
E5E97_16970	COG1760	l-serine dehydratase
E5E97_16975	COG2951	lytic endotransglycosylase activity
E5E97_16980	COG3100	YcgL domain-containing protein
E5E97_16985	COG0850	regulation of cytokinetic process
E5E97_16990	COG2894	cell division
E5E97_17000	COG3099	Belongs to the UPF0263 family
E5E97_17005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E97_17045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5E97_17050	COG0697	spore germination
E5E97_17055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E5E97_17060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E97_17070	COG0307	riboflavin synthase, alpha
E5E97_17080	COG0534	Mate efflux family protein
E5E97_17135	COG1560	Kdo2-lipid A biosynthetic process
E5E97_17140	COG1560	Kdo2-lipid A biosynthetic process
E5E97_17150	COG0583	DNA-binding transcription factor activity
E5E97_17155	COG0673	inositol 2-dehydrogenase activity
E5E97_17160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5E97_17165	COG0583	DNA-binding transcription factor activity
E5E97_17175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E97_17185	COG5001	Diguanylate cyclase
E5E97_17185	COG3300	MHYT domain
E5E97_17190	COG2723	6-phospho-beta-galactosidase activity
E5E97_17195	COG0583	DNA-binding transcription factor activity
E5E97_17225	COG0730	response to heat
E5E97_17235	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_17245	COG1024	Enoyl-CoA hydratase
E5E97_17255	COG1960	acyl-CoA dehydrogenase activity
E5E97_17265	COG1960	acyl-CoA dehydrogenase activity
E5E97_17270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5E97_17305	COG1584	GPR1 FUN34 yaaH family protein
E5E97_17320	COG1115	amino acid carrier protein
E5E97_17325	COG1024	Enoyl-CoA hydratase
E5E97_17340	COG3162	membrane
E5E97_17345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E97_17350	COG0488	(ABC) transporter
E5E97_17355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E97_17360	COG0776	regulation of translation
E5E97_17365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5E97_17370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5E97_17375	COG0740	serine-type endopeptidase activity
E5E97_17380	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5E97_17395	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E5E97_17400	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E97_17405	COG1136	(ABC) transporter
E5E97_17410	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E97_17420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5E97_17425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5E97_17430	COG4166	transmembrane transport
E5E97_17435	COG0697	spore germination
E5E97_17445	COG2062	phosphohistidine phosphatase, SixA
E5E97_17500	COG0519	Catalyzes the synthesis of GMP from XMP
E5E97_17500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E97_17505	COG0516	GMP reductase activity
E5E97_17505	COG0517	IMP dehydrogenase activity
E5E97_17510	COG3158	transport of potassium into the cell
E5E97_17530	COG0697	spore germination
E5E97_17535	COG1570	exodeoxyribonuclease VII activity
E5E97_17550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E97_17555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5E97_17560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5E97_17605	COG4771	TonB-dependent receptor
E5E97_17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E97_17615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E97_17620	COG1120	ATPase activity
E5E97_17630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5E97_17635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E97_17645	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_17650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E97_17655	COG3433	isochorismatase activity
E5E97_17655	COG1535	isochorismatase
E5E97_17660	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5E97_17680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E97_17685	COG5001	Diguanylate cyclase
E5E97_17685	COG3300	MHYT domain
E5E97_17700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E97_17710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5E97_17715	COG0563	adenylate kinase activity
E5E97_17725	COG0326	Molecular chaperone. Has ATPase activity
E5E97_17735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5E97_17760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_17770	COG3158	transport of potassium into the cell
E5E97_17775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E97_17780	COG0651	ATP synthesis coupled electron transport
E5E97_17785	COG0650	Formate hydrogenlyase subunit 4
E5E97_17795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_17800	COG3260	NADH ubiquinone oxidoreductase 20
E5E97_17815	COG1921	L-seryl-tRNASec selenium transferase activity
E5E97_17825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E5E97_17830	COG0298	carbon dioxide binding
E5E97_17840	COG0309	Hydrogenase expression formation protein (HypE)
E5E97_17845	COG0375	protein maturation
E5E97_17850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5E97_17855	COG1124	(ABC) transporter
E5E97_17860	COG0444	Belongs to the ABC transporter superfamily
E5E97_17865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E97_17870	COG0601	transmembrane transport
E5E97_17880	COG1773	rubredoxin
E5E97_17885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5E97_17890	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E5E97_17895	COG5557	Pfam Polysulphide reductase, NrfD
E5E97_17900	COG0437	4 iron, 4 sulfur cluster binding
E5E97_17905	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E5E97_17910	COG0745	RESPONSE REGULATOR receiver
E5E97_17920	COG2198	Histidine kinase
E5E97_17920	COG0643	Histidine kinase
E5E97_17925	COG0840	transmembrane signaling receptor activity
E5E97_17925	COG3290	protein histidine kinase activity
E5E97_17930	COG0835	chemotaxis
E5E97_17940	COG2201	protein-glutamate methylesterase activity
E5E97_17950	COG0840	transmembrane signaling receptor activity
E5E97_17990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5E97_18035	COG0659	secondary active sulfate transmembrane transporter activity
E5E97_18065	COG0672	)-iron permease
E5E97_18085	COG2814	Major facilitator Superfamily
E5E97_18095	COG1136	(ABC) transporter
E5E97_18125	COG1139	Iron-sulfur cluster binding protein
E5E97_18135	COG1620	l-lactate permease
E5E97_18140	COG0583	DNA-binding transcription factor activity
E5E97_18150	COG0346	lactoylglutathione lyase activity
E5E97_18155	COG0596	Alpha beta hydrolase
E5E97_18180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E97_18190	COG0527	aspartate kinase activity
E5E97_18200	COG1368	sulfuric ester hydrolase activity
E5E97_18205	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5E97_18220	COG0393	Putative heavy-metal-binding
E5E97_18240	COG1252	NADH dehydrogenase
E5E97_18245	COG3150	esterase
E5E97_18265	COG2354	Protein conserved in bacteria
E5E97_18275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E97_18280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E97_18315	COG0537	adenosine 5'-monophosphoramidase activity
E5E97_18330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5E97_18345	COG1301	dicarboxylic acid transport
E5E97_18355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E97_18360	COG0861	Integral membrane protein TerC family
E5E97_18375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E97_18380	COG0601	transmembrane transport
E5E97_18390	COG2095	MarC family integral membrane protein
E5E97_18400	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_18400	COG1454	alcohol dehydrogenase
E5E97_18405	COG2199	diguanylate cyclase activity
E5E97_18405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E97_18410	COG3275	phosphorelay sensor kinase activity
E5E97_18415	COG3279	Response regulator of the LytR AlgR family
E5E97_18420	COG1966	Carbon starvation protein
E5E97_18430	COG1566	PFAM secretion protein HlyD family protein
E5E97_18435	COG1061	Type III restriction enzyme res subunit
E5E97_18440	COG2027	D-alanyl-D-alanine carboxypeptidase
E5E97_18445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5E97_18455	COG0436	Aminotransferase
E5E97_18460	COG1288	antiporter activity
E5E97_18465	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E97_18480	COG0697	spore germination
E5E97_18485	COG4657	Part of a membrane complex involved in electron transport
E5E97_18490	COG2878	Part of a membrane complex involved in electron transport
E5E97_18500	COG4658	electron transport chain
E5E97_18505	COG4659	FMN binding
E5E97_18510	COG4660	Part of a membrane complex involved in electron transport
E5E97_18515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5E97_18520	COG0346	lactoylglutathione lyase activity
E5E97_18535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5E97_18540	COG2056	Na+-H+ antiporter family
E5E97_18550	COG2050	protein possibly involved in aromatic compounds catabolism
E5E97_18560	COG0277	FAD linked oxidase domain protein
E5E97_18560	COG0247	lactate metabolic process
E5E97_18570	COG1253	flavin adenine dinucleotide binding
E5E97_18575	COG1902	pentaerythritol trinitrate reductase activity
E5E97_18585	COG0647	UMP catabolic process
E5E97_18590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E97_18590	COG4651	solute:proton antiporter activity
E5E97_18600	COG0367	asparagine synthase
E5E97_18610	COG0625	glutathione transferase activity
E5E97_18615	COG0625	glutathione transferase activity
E5E97_18625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5E97_18640	COG0564	pseudouridine synthase activity
E5E97_18645	COG2199	diguanylate cyclase activity
E5E97_18645	COG2203	Gaf domain
E5E97_18650	COG0840	transmembrane signaling receptor activity
E5E97_18660	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5E97_18660	COG0392	lysyltransferase activity
E5E97_18670	COG2194	sulfuric ester hydrolase activity
E5E97_18690	COG0670	Belongs to the BI1 family
E5E97_18695	COG1289	transmembrane transporter activity
E5E97_18700	COG2920	part of a sulfur-relay system
E5E97_18705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E5E97_18710	COG0285	dihydrofolate synthase activity
E5E97_18715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5E97_18720	COG0101	tRNA pseudouridine synthase activity
E5E97_18730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E97_18735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E97_18740	COG0671	phosphoesterase, PA-phosphatase related
E5E97_18745	COG1464	Belongs to the NlpA lipoprotein family
E5E97_18785	COG0574	Belongs to the PEP-utilizing enzyme family
E5E97_18785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5E97_18790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5E97_18850	COG1242	4 iron, 4 sulfur cluster binding
E5E97_18855	COG0067	glutamate synthase
E5E97_18855	COG0070	glutamate synthase
E5E97_18855	COG0069	glutamate synthase activity
E5E97_18860	COG0493	'glutamate synthase
E5E97_18870	COG0765	amino acid transport
E5E97_18875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_18905	COG4104	PAAR repeat-containing protein
E5E97_18915	COG0513	Belongs to the DEAD box helicase family
E5E97_18920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E97_18955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E97_18960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5E97_18965	COG0505	Belongs to the CarA family
E5E97_18970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5E97_18980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5E97_18985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5E97_18990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E97_18995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5E97_19000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E97_19010	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E5E97_19020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_19020	COG2205	protein histidine kinase activity
E5E97_19035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E97_19060	COG0023	Translation Initiation Factor
E5E97_19065	COG2119	membrane
E5E97_19095	COG2203	Gaf domain
E5E97_19095	COG2199	diguanylate cyclase activity
E5E97_19120	COG1106	Psort location Cytoplasmic, score
E5E97_19135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E97_19145	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E97_19150	COG3301	Polysulphide reductase, NrfD
E5E97_19155	COG0437	4 iron, 4 sulfur cluster binding
E5E97_19160	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E97_19235	COG2197	response regulator
E5E97_19240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5E97_19245	COG2835	tetraacyldisaccharide 4'-kinase activity
E5E97_19250	COG1663	tetraacyldisaccharide 4'-kinase activity
E5E97_19260	COG2333	competence protein COMEC
E5E97_19260	COG0658	competence protein
E5E97_19275	COG0433	COG0433 Predicted ATPase
E5E97_19280	COG1448	Aminotransferase
E5E97_19295	COG1199	ATP-dependent helicase activity
E5E97_19305	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5E97_19310	COG0477	Major facilitator Superfamily
E5E97_19315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5E97_19340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E97_19355	COG2271	Major facilitator Superfamily
E5E97_19365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_19370	COG0765	amino acid transport
E5E97_19395	COG0531	amino acid
E5E97_19410	COG1253	flavin adenine dinucleotide binding
E5E97_19415	COG0704	Plays a role in the regulation of phosphate uptake
E5E97_19425	COG0581	inorganic phosphate transmembrane transporter activity
E5E97_19430	COG0573	inorganic phosphate transmembrane transporter activity
E5E97_19435	COG0590	tRNA wobble adenosine to inosine editing
E5E97_19450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5E97_19470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5E97_19475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5E97_19480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5E97_19485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5E97_19495	COG3852	Histidine kinase
E5E97_19510	COG2716	regulation of RNA biosynthetic process
E5E97_19515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5E97_19525	COG2239	Acts as a magnesium transporter
E5E97_19545	COG1706	bacterial-type flagellum-dependent cell motility
E5E97_19550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5E97_19560	COG4787	bacterial-type flagellum-dependent cell motility
E5E97_19580	COG1815	bacterial-type flagellum-dependent cell motility
E5E97_19585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5E97_19590	COG0835	chemotaxis
E5E97_19590	COG0784	Response regulator, receiver
E5E97_19595	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E5E97_19610	COG0622	Phosphoesterase
E5E97_19640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E97_19645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E97_19650	COG1882	Formate acetyltransferase
E5E97_19655	COG1349	DNA-binding transcription factor activity
E5E97_19690	COG1278	Cold shock
E5E97_19730	COG3132	Protein of unknown function, DUF480
E5E97_19750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5E97_19770	COG0110	maltose O-acetyltransferase activity
E5E97_19790	COG0110	maltose O-acetyltransferase activity
E5E97_19795	COG0110	maltose O-acetyltransferase activity
E5E97_19815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5E97_19830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E97_19835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_19840	COG1309	transcriptional regulator
E5E97_19860	COG1946	Acyl-CoA thioesterase
E5E97_19870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5E97_19880	COG0009	L-threonylcarbamoyladenylate synthase
E5E97_19890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5E97_19895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E97_19895	COG0512	Glutamine amidotransferase of anthranilate synthase
E5E97_19900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E97_19905	COG0134	indole-3-glycerol-phosphate synthase activity
E5E97_19905	COG0135	phosphoribosylanthranilate isomerase activity
E5E97_19910	COG0133	tryptophan synthase activity
E5E97_19915	COG0159	tryptophan synthase activity
E5E97_19970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E97_19980	COG3423	Transcriptional regulator
E5E97_19985	COG2801	Transposase and inactivated derivatives
E5E97_19990	COG2842	Transposition protein
E5E97_20105	COG0640	Transcriptional regulator
E5E97_20120	COG4373	Mu-like prophage FluMu protein gp28
E5E97_20125	COG4383	Mu-like prophage protein gp29
E5E97_20140	COG4397	Mu-like prophage major head subunit gpT
E5E97_20180	COG4386	tail sheath protein
E5E97_20210	COG4384	Bacteriophage Mu Gp45 protein
E5E97_20220	COG3299	homolog of phage Mu protein gp47
E5E97_20250	COG4521	taurine ABC transporter
E5E97_20255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5E97_20260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5E97_20265	COG2175	clavaminate synthase activity
E5E97_20275	COG2814	Major facilitator Superfamily
E5E97_20280	COG0109	protoheme IX farnesyltransferase activity
E5E97_20285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5E97_20290	COG1845	cytochrome c oxidase, subunit III
E5E97_20295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5E97_20300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5E97_20350	COG2211	Major facilitator Superfamily
E5E97_20365	COG0708	Exodeoxyribonuclease III
E5E97_20385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_20390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E97_20410	COG0095	Lipoate-protein ligase
E5E97_20440	COG0640	Transcriptional regulator
E5E97_20455	COG1285	pathogenesis
E5E97_20485	COG0484	heat shock protein binding
E5E97_20490	COG0443	Heat shock 70 kDa protein
E5E97_20495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5E97_20500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5E97_20505	COG0497	DNA recombination
E5E97_20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_20525	COG0577	efflux transmembrane transporter activity
E5E97_20525	COG1136	(ABC) transporter
E5E97_20535	COG2375	cellular response to nickel ion
E5E97_20540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E97_20560	COG3152	Membrane
E5E97_20580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E97_20585	COG1917	Cupin 2, conserved barrel domain protein
E5E97_20585	COG1396	sequence-specific DNA binding
E5E97_20600	COG0531	amino acid
E5E97_20605	COG0531	amino acid
E5E97_20615	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5E97_20625	COG3384	dioxygenase
E5E97_20630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E97_20630	COG2205	protein histidine kinase activity
E5E97_20645	COG0813	purine-nucleoside phosphorylase activity
E5E97_20665	COG0488	(ABC) transporter
E5E97_20670	COG4319	ketosteroid isomerase
E5E97_20675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E97_20680	COG0083	homoserine kinase activity
E5E97_20695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E5E97_20700	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E5E97_20715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E97_20725	COG0745	RESPONSE REGULATOR receiver
E5E97_20740	COG4988	ABC transporter
E5E97_20745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5E97_20765	COG1720	tRNA m6t6A37 methyltransferase activity
E5E97_20780	COG0542	response to heat
E5E97_20785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5E97_20790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E97_20800	COG2190	(PTS) system
E5E97_20815	COG3038	cytochrome b561
E5E97_20830	COG0419	ATPase involved in DNA repair
E5E97_20835	COG0420	3'-5' exonuclease activity
E5E97_20845	COG2974	May be involved in recombination
E5E97_20860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E97_20860	COG4651	solute:proton antiporter activity
E5E97_20875	COG0469	pyruvate kinase activity
E5E97_20880	COG3264	Mechanosensitive ion channel
E5E97_20880	COG1196	nuclear chromosome segregation
E5E97_20890	COG2706	6-phosphogluconolactonase activity
E5E97_20910	COG0281	malic enzyme
E5E97_20925	COG0437	4 iron, 4 sulfur cluster binding
E5E97_20930	COG3383	formate dehydrogenase (NAD+) activity
E5E97_20930	COG3383	formate dehydrogenase (NAD+) activity
E5E97_20965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E97_20970	COG1910	domain protein
E5E97_20975	COG3852	Histidine kinase
E5E97_20980	COG2204	response regulator
E5E97_20990	COG4662	Binding-protein-dependent transport system inner membrane component
E5E97_21000	COG0746	molybdenum cofactor guanylyltransferase activity
E5E97_21005	COG0303	'Molybdopterin
E5E97_21010	COG1289	transmembrane transporter activity
E5E97_21015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E97_21045	COG3220	belongs to the UPF0276 family
E5E97_21080	COG2205	protein histidine kinase activity
E5E97_21080	COG0784	Response regulator, receiver
E5E97_21085	COG4166	transmembrane transport
E5E97_21090	COG0601	transmembrane transport
E5E97_21095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E97_21100	COG0444	Belongs to the ABC transporter superfamily
E5E97_21105	COG4608	Belongs to the ABC transporter superfamily
E5E97_21115	COG2971	BadF BadG BcrA BcrD
E5E97_21125	COG0840	transmembrane signaling receptor activity
E5E97_21145	COG3724	N-succinylarginine dihydrolase activity
E5E97_21150	COG0616	signal peptide processing
E5E97_21155	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_21160	COG0583	DNA-binding transcription factor activity
E5E97_21170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E97_21180	COG0583	DNA-binding transcription factor activity
E5E97_21190	COG1881	PFAM PEBP family protein
E5E97_21200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E5E97_21200	COG3408	Glycogen debranching enzyme
E5E97_21205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E97_21210	COG0739	heme binding
E5E97_21215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5E97_21240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5E97_21250	COG3091	SprT-like family
E5E97_21275	COG1678	Uncharacterized ACR, COG1678
E5E97_21280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5E97_21315	COG0714	Associated with various cellular activities
E5E97_21330	COG1115	amino acid carrier protein
E5E97_21335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E97_21350	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5E97_21360	COG1301	dicarboxylic acid transport
E5E97_21370	COG2912	Transglutaminase-like superfamily
E5E97_21380	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E97_21385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5E97_21390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5E97_21395	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5E97_21400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5E97_21410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5E97_21415	COG0737	Belongs to the 5'-nucleotidase family
E5E97_21420	COG0193	aminoacyl-tRNA hydrolase activity
E5E97_21425	COG0012	GTP binding
E5E97_21470	COG0490	domain, Protein
E5E97_21470	COG0471	metal ion transport
E5E97_21500	COG0366	Alpha amylase catalytic
E5E97_21510	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5E97_21510	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5E97_21510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E97_21510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5E97_21525	COG2801	Transposase and inactivated derivatives
E5E97_21530	COG2842	Transposition protein
E5E97_21645	COG0640	Transcriptional regulator
E5E97_21660	COG4373	Mu-like prophage FluMu protein gp28
E5E97_21665	COG4383	Mu-like prophage protein gp29
E5E97_21680	COG4397	Mu-like prophage major head subunit gpT
E5E97_21720	COG4386	tail sheath protein
E5E97_21735	COG3941	tape measure
E5E97_21750	COG4384	Bacteriophage Mu Gp45 protein
E5E97_21760	COG3299	homolog of phage Mu protein gp47
E5E97_21780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E97_21830	COG1012	belongs to the aldehyde dehydrogenase family
E5E97_21840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5E97_21855	COG0180	Tryptophanyl-tRNA synthetase
E5E97_21865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5E97_21875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E5E97_21885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5E97_21890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5E97_21920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E5E97_21925	COG0583	DNA-binding transcription factor activity
E5E97_21945	COG0583	DNA-binding transcription factor activity
E5E97_21960	COG0739	heme binding
E5E97_21970	COG3264	Mechanosensitive ion channel
E5E97_21970	COG1511	domain protein
E5E97_21975	COG0584	glycerophosphoryl diester phosphodiesterase
E5E97_21985	COG1053	succinate dehydrogenase
E5E97_21990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5E97_21995	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E5E97_22020	COG3214	Protein conserved in bacteria
E5E97_22055	COG0745	RESPONSE REGULATOR receiver
E5E97_22060	COG0642	Histidine kinase
E5E97_22070	COG0516	GMP reductase activity
E5E97_22080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5E97_22085	COG3647	Membrane
E5E97_22095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E97_22115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E97_22130	COG3706	GGDEF domain
E5E97_22140	COG1335	isochorismatase
E5E97_22145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E97_22150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E97_22155	COG1702	phosphate starvation-inducible protein PhoH
E5E97_22160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5E97_22165	COG4535	Mg2 and Co2 transporter CorC
E5E97_22170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5E97_22175	COG2888	peptidyl-tyrosine sulfation
E5E97_22180	COG0495	leucyl-tRNA aminoacylation
E5E97_22200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5E97_22205	COG0799	negative regulation of ribosome biogenesis
E5E97_22210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5E97_22215	COG0768	penicillin binding
E5E97_22220	COG0772	Belongs to the SEDS family
E5E97_22225	COG0772	Belongs to the SEDS family
E5E97_22230	COG2951	lytic endotransglycosylase activity
E5E97_22235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5E97_22240	COG1686	Belongs to the peptidase S11 family
E5E97_22245	COG2921	Belongs to the UPF0250 family
E5E97_22250	COG0321	lipoyl(octanoyl) transferase activity
E5E97_22260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5E97_22270	COG3545	Serine hydrolase
E5E97_22275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E97_22290	COG0789	Transcriptional regulator
E5E97_22295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5E97_22300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E97_22305	COG1970	mechanosensitive ion channel activity
E5E97_22310	COG3706	GGDEF domain
E5E97_22315	COG4974	Belongs to the 'phage' integrase family
E5E97_22325	COG0312	modulator of DNA gyrase
E5E97_22330	COG0312	modulator of DNA gyrase
E5E97_22395	COG3275	phosphorelay sensor kinase activity
E5E97_22400	COG3279	Response regulator of the LytR AlgR family
E5E97_22405	COG1966	Carbon starvation protein
E5E97_22415	COG0114	fumarate hydratase activity
E5E97_22425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5E97_22435	COG2211	Major facilitator Superfamily
E5E97_22440	COG1185	polyribonucleotide nucleotidyltransferase activity
E5E97_22445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5E97_22450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5E97_22455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5E97_22460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5E97_22465	COG0195	Participates in both transcription termination and antitermination
E5E97_22470	COG0779	Required for maturation of 30S ribosomal subunits
E5E97_22485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5E97_22490	COG0149	triose-phosphate isomerase activity
E5E97_22495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5E97_22500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5E97_22510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5E97_22515	COG1534	Rna-binding protein
E5E97_22530	COG1360	Flagellar Motor Protein
E5E97_22535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E97_22540	COG1722	exodeoxyribonuclease VII activity
E5E97_22545	COG0142	geranyltranstransferase activity
E5E97_22550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5E97_22570	COG4172	Belongs to the ABC transporter superfamily
E5E97_22575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5E97_22580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5E97_22585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E97_22590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5E97_22610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E97_22610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E97_22615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5E97_22625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5E97_22635	COG3381	protein complex oligomerization
E5E97_22665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E97_22670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5E97_22675	COG0511	ligase activity, forming carbon-carbon bonds
E5E97_22680	COG0439	Biotin carboxylase
E5E97_22690	COG4145	pantothenate transmembrane transporter activity
E5E97_22695	COG2190	(PTS) system
E5E97_22695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E97_22695	COG1263	PTS System
E5E97_22700	COG0583	DNA-binding transcription factor activity
E5E97_22705	COG0604	alcohol dehydrogenase
E5E97_22710	COG2264	protein methyltransferase activity
E5E97_22725	COG0778	Nitroreductase
E5E97_22730	COG1902	pentaerythritol trinitrate reductase activity
E5E97_22730	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E97_22735	COG0616	signal peptide processing
E5E97_22755	COG3139	Protein of unknown function (DUF1315)
E5E97_22760	COG0252	asparaginase activity
E5E97_22765	COG0786	glutamate:sodium symporter activity
E5E97_22780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5E97_22785	COG0384	phenazine biosynthesis protein PhzF
E5E97_22790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E97_22795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E97_22800	COG0175	sulfate reduction
E5E97_22805	COG2113	Glycine betaine
E5E97_22810	COG4176	ABC-type proline glycine betaine transport system permease component
E5E97_22815	COG4175	Glycine betaine
E5E97_22840	COG3610	response to peptide
E5E97_22845	COG2966	Psort location CytoplasmicMembrane, score
E5E97_22855	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E97_22870	COG1028	Short-chain dehydrogenase reductase Sdr
E5E97_22880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E97_22905	COG2986	histidine ammonia-lyase
E5E97_22930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E97_22970	COG1858	cytochrome C peroxidase
E5E97_22985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E97_22990	COG2146	nitrite reductase [NAD(P)H] activity
E5E97_22990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E97_22995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E97_22995	COG2146	nitrite reductase [NAD(P)H] activity
E5E97_23000	COG1116	anion transmembrane transporter activity
E5E97_23005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5E97_23010	COG1116	anion transmembrane transporter activity
E5E97_23010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5E97_23025	COG0243	molybdopterin cofactor binding
E5E97_23055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5E97_23075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5E97_23090	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E97_23100	COG4608	Belongs to the ABC transporter superfamily
E5E97_23105	COG0444	Belongs to the ABC transporter superfamily
E5E97_23115	COG4239	(ABC) transporter, permease
E5E97_23120	COG4174	ABC transporter (Permease)
E5E97_23135	COG0811	peptide transport
E5E97_23140	COG0811	peptide transport
E5E97_23145	COG0848	biopolymer transport protein
E5E97_23195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E97_23200	COG0840	transmembrane signaling receptor activity
E5E97_23210	COG1278	Cold shock
E5E97_23250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5E97_23255	COG1162	GTPase activity
E5E97_23260	COG0688	phosphatidylethanolamine metabolic process
E5E97_23265	COG4628	conserved protein (DUF2132)
E5E97_23280	COG3059	membrane
E5E97_23285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E97_23290	COG2207	Transcriptional regulator
E5E97_23300	COG3300	MHYT domain
E5E97_23300	COG5001	Diguanylate cyclase
E5E97_23305	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E5E97_23340	COG1132	(ABC) transporter
E5E97_23355	COG2897	thiosulfate sulfurtransferase activity
E5E97_23360	COG2066	Belongs to the glutaminase family
E5E97_23365	COG3171	Protein conserved in bacteria
E5E97_23370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5E97_23375	COG2234	aminopeptidase activity
E5E97_23375	COG4935	Belongs to the peptidase S8 family
E5E97_23380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E97_23385	COG2200	EAL domain
E5E97_23390	COG1090	epimerase
E5E97_23395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5E97_23400	COG4181	ATPase activity
E5E97_23405	COG2755	lipolytic protein G-D-S-L family
E5E97_23410	COG0835	chemotaxis
E5E97_23410	COG0784	Response regulator, receiver
E5E97_23465	COG2985	domain, Protein
E5E97_23465	COG0569	domain protein
E5E97_23470	COG1272	protein, Hemolysin III
E5E97_23475	COG0076	glutamate decarboxylase activity
E5E97_23480	COG2917	probably involved in intracellular septation
E5E97_23485	COG2350	Protein conserved in bacteria
E5E97_23495	COG1555	photosystem II stabilization
E5E97_23500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5E97_23505	COG3104	oligopeptide transport
E5E97_23510	COG0745	RESPONSE REGULATOR receiver
E5E97_23540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E97_23555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5E97_23595	COG0316	Belongs to the HesB IscA family
E5E97_23655	COG1192	Involved in chromosome partitioning
E5E97_23660	COG3077	Addiction module antitoxin, RelB DinJ family