locus-tag class description C2U37_00015 ENOG4105CGK Exodeoxyribonuclease III C2U37_00025 ENOG4105EP1 Efflux transporter rnd family, mfp subunit C2U37_00030 ENOG4108IJF Heavy metal efflux pump, CzcA C2U37_00045 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) C2U37_00050 ENOG4105BZU Histidine kinase C2U37_00065 ENOG4105KFG YeeE YedE family protein C2U37_00075 ENOG41080HT Transcriptional regulator, arsr family C2U37_00085 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase C2U37_00100 ENOG4105WBN Transcriptional regulator (LacI family C2U37_00115 ENOG4105D7K pfkb domain protein C2U37_00125 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2U37_00130 ENOG4105CFG Acts as a chaperone (By similarity) C2U37_00135 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C2U37_00140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C2U37_00145 ENOG4105BZU Histidine kinase C2U37_00150 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C2U37_00160 ENOG4105DJY efflux transporter, rnd family, mfp subunit C2U37_00165 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U37_00170 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U37_00175 ENOG4105Q26 Siderophore-interacting protein C2U37_00190 ENOG4105W8I Transcriptional regulator C2U37_00195 ENOG4105BZC d-serine deaminase C2U37_00205 ENOG4108HMX isocitrate dehydrogenase (NADP) C2U37_00235 ENOG4108W0I acetyltransferase C2U37_00240 ENOG4108R99 pseudouridine synthase C2U37_00250 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C2U37_00255 ENOG41075W9 High frequency lysogenization protein HflD homolog C2U37_00260 ENOG4107QTF adenylosuccinate lyase C2U37_00265 ENOG4105EZE Cupin 4 family protein C2U37_00270 ENOG4105CA9 Pyruvate kinase C2U37_00275 ENOG4105EGS Mechanosensitive ion channel C2U37_00295 ENOG4105C2W permease C2U37_00305 ENOG4107R1I NAD-dependent malic enzyme C2U37_00310 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C2U37_00315 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C2U37_00320 ENOG4105DR8 Membrane C2U37_00325 ENOG4108ESY Metal dependent phosphohydrolase C2U37_00335 ENOG4107SDU Methyl-accepting chemotaxis C2U37_00355 ENOG4105E18 UPF0276 protein C2U37_00365 ENOG4105C94 Transporter C2U37_00380 ENOG4105F2I Transposase C2U37_00400 ENOG4105D98 threonine synthase C2U37_00405 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C2U37_00420 ENOG4106FVC RNA methyltransferase C2U37_00425 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) C2U37_00440 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C2U37_00450 ENOG41065U4 response regulator C2U37_00465 ENOG4108JJ9 ABC, transporter C2U37_00470 ENOG4108JJ8 (ABC) transporter C2U37_00490 ENOG4108R96 Methyltransferase, YaeB family C2U37_00505 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U37_00510 ENOG4105C6T cysteine synthase C2U37_00515 ENOG4105KZ7 phosphocarrier protein hpr C2U37_00525 ENOG4105C5Y PTS System C2U37_00535 ENOG4105EYH Exonuclease C2U37_00540 ENOG4107RH8 nuclease SbcCD subunit D C2U37_00545 ENOG4105WCN acetyltransferase C2U37_00550 ENOG4105DH7 May be involved in recombination (By similarity) C2U37_00560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U37_00565 ENOG4105CKD glutathione-regulated potassium-efflux system protein C2U37_00570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_00600 ENOG4105CJP fad dependent oxidoreductase C2U37_00605 ENOG4107VRI Transcriptional regulator C2U37_00610 ENOG4105C26 Dehydrogenase C2U37_00620 ENOG4108JPW Aminotransferase C2U37_00625 ENOG4105CUB amino acid C2U37_00630 ENOG4105CUB amino acid C2U37_00645 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U37_00650 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C2U37_00660 ENOG4105XIQ Protein of unknown function (DUF2517) C2U37_00680 ENOG4105BZU Histidine kinase C2U37_00690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U37_00705 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) C2U37_00710 ENOG4107TT5 NLP P60 protein C2U37_00715 ENOG4107YAK holo-(acyl carrier protein) synthase 2 C2U37_00720 ENOG4107QR8 Thioredoxin C2U37_00730 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2U37_00735 ENOG4105CIY formyltetrahydrofolate deformylase C2U37_00750 ENOG4105F3T (LipO)protein C2U37_00760 ENOG4105E4C Lytic transglycosylase catalytic C2U37_00770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C2U37_00775 ENOG4105EP9 oxidoreductase C2U37_00815 ENOG4105CCT upf0313 protein C2U37_00820 ENOG4105BZS acriflavin resistance protein C2U37_00830 ENOG4105BZU Histidine kinase C2U37_00835 ENOG4105D78 K07001 NTE family protein C2U37_00840 ENOG4105C8J )-transporter C2U37_00855 ENOG4105UYK outer membrane protein a C2U37_00865 ENOG4105UYK outer membrane protein a C2U37_00870 ENOG4107R1I NAD-dependent malic enzyme C2U37_00875 ENOG41075H3 AraC family transcriptional regulator C2U37_00880 ENOG4107QI1 Mate efflux family protein C2U37_00885 ENOG4105RKX Protein of unknown function (DUF2498) C2U37_00890 ENOG4105BZU Histidine kinase C2U37_00895 ENOG4105C2W permease C2U37_00900 ENOG4108KMH lipoate-protein ligase a C2U37_00905 ENOG4105BZG amino acid carrier protein C2U37_00925 ENOG4105PTV Nudix Hydrolase C2U37_00935 ENOG4105CDA abc transporter atp-binding protein C2U37_00940 ENOG4105DRP amino acid AbC transporter C2U37_00945 ENOG4105EZ7 amino acid ABC transporter C2U37_00965 ENOG4105CJ1 ABC, transporter C2U37_00970 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U37_00980 ENOG4106N3A copper homeostasis protein cutc C2U37_00985 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) C2U37_00995 ENOG4105ERG peptidase m48, ste24p C2U37_01005 ENOG4105BZU Histidine kinase C2U37_01010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U37_01015 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase C2U37_01020 ENOG4105BZU Histidine kinase C2U37_01025 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C2U37_01030 ENOG4105C26 Dehydrogenase C2U37_01040 ENOG4108IPJ Membrane C2U37_01050 ENOG4105CPC Aldo Keto reductase C2U37_01060 ENOG4106YYS transcriptional regulatory protein C2U37_01065 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C2U37_01095 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U37_01180 ENOG4105FA0 parb-like partition protein C2U37_01265 ENOG4105D78 K07001 NTE family protein C2U37_01285 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U37_01290 ENOG4105BZS acriflavin resistance protein C2U37_01295 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U37_01305 ENOG4106NZI LysR family Transcriptional regulator C2U37_01395 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) C2U37_01400 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C2U37_01410 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2U37_01415 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) C2U37_01425 ENOG4105EXN Sulfate transport protein CysZ C2U37_01430 ENOG4105EN6 Membrane C2U37_01440 ENOG4105EAQ (twin-arginine translocation) pathway signal C2U37_01445 ENOG4105DIT ErfK YbiS YcfS YnhG family protein C2U37_01475 ENOG4107T9C Alpha amylase catalytic region C2U37_01485 ENOG4108W5X Transcriptional Regulator, LuxR family C2U37_01515 ENOG4105BZU Histidine kinase C2U37_01520 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C2U37_01525 ENOG4105C9K Endothelin-converting enzyme 1 C2U37_01535 ENOG4105C5H ABC transporter C2U37_01545 ENOG4105DVH amino acid C2U37_01550 ENOG4105C44 Serine transporter C2U37_01555 ENOG4105EQ2 LysR family Transcriptional regulator C2U37_01565 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C2U37_01570 ENOG4105C0B DNA polymerase III (alpha subunit) C2U37_01575 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U37_01580 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U37_01585 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U37_01590 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C2U37_01595 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U37_01600 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) C2U37_01610 ENOG4105DZP Membrane-associated zinc metalloprotease C2U37_01615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2U37_01620 ENOG4105KNE Phosphatidate cytidylyltransferase C2U37_01625 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2U37_01630 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C2U37_01635 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2U37_01640 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C2U37_01645 ENOG4105CE9 30S ribosomal protein S2 C2U37_01650 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2U37_01655 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C2U37_01660 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C2U37_01665 ENOG4108T8E UPF0325 protein C2U37_01670 ENOG4105CI1 PTS System C2U37_01680 ENOG4107W52 maltose operon periplasmic protein C2U37_01690 ENOG4105QDK Flavodoxin C2U37_01695 ENOG4105DR9 pseudouridine synthase C2U37_01700 ENOG4105WP7 tRNA pseudouridine synthase C C2U37_01725 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein C2U37_01730 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) C2U37_01735 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C2U37_01745 ENOG4105BZU Histidine kinase C2U37_01750 ENOG4105EWT decarboxylase family C2U37_01755 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease C2U37_01760 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2U37_01770 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) C2U37_01785 ENOG4105ETT transcriptional Regulator, LysR family C2U37_01790 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_01795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U37_01810 ENOG4105CJ2 (LipO)protein C2U37_01815 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) C2U37_01820 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_01825 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_01830 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_01835 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_01840 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_01845 ENOG4105M85 Bola protein C2U37_01850 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C2U37_01860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C2U37_01870 ENOG4105EYM Major Facilitator superfamily C2U37_01880 ENOG4108VPT UPF0234 protein C2U37_01885 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C2U37_01890 ENOG4107S0N DJ-1 family C2U37_01895 ENOG4105CHH sulfate transporter C2U37_01910 ENOG4105CS2 ec 3.2.1.21 C2U37_01915 ENOG4105VCP PTS System C2U37_01935 ENOG4105CMR udp-glucose 4-epimerase C2U37_01945 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C2U37_01950 ENOG4108RMU ferritin dps family protein C2U37_01975 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2U37_01990 ENOG4105EMU Dehydrogenase C2U37_02000 ENOG4105CVP deoxyribo-dipyrimidine photolyase C2U37_02005 ENOG4108XDN Transcriptional regulator C2U37_02010 ENOG4107SEY Conserved Protein C2U37_02065 ENOG4105D8V Glucose sorbosone dehydrogenase C2U37_02075 ENOG4105MVE transcriptional regulator C2U37_02085 ENOG4105G63 Type III effector Hrp-dependent C2U37_02090 ENOG4105FB2 class II Aldolase C2U37_02095 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C2U37_02100 ENOG4105EXW epimerase dehydratase C2U37_02105 ENOG4105C6Z Gluconate C2U37_02115 ENOG4108W2P Methyl-accepting chemotaxis C2U37_02125 ENOG4105E1F short-chain dehydrogenase reductase C2U37_02150 ENOG4105CTD carboxy-peptidase C2U37_02170 ENOG4105XDF Protein of unknown function (DUF1272) C2U37_02180 ENOG4105CFP Peptidase U32 C2U37_02185 ENOG4105N14 lysine exporter protein LysE YggA C2U37_02195 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U37_02220 ENOG4108NJZ Sensory box GGDEF EAL domain protein C2U37_02230 ENOG4105DB1 molybdopterin oxidoreductase C2U37_02235 ENOG4106WHD Tetrathionate reductase C2U37_02240 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U37_02245 ENOG4105BZU Histidine kinase C2U37_02250 ENOG4108ZXC Two component transcriptional regulator, luxr family C2U37_02255 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) C2U37_02260 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U37_02265 ENOG4105CW7 secretion protein, HlyD family C2U37_02285 ENOG4105C26 Dehydrogenase C2U37_02290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U37_02295 ENOG4105CDU Replicative dna helicase C2U37_02305 ENOG4105CGH 5'-nucleotidase C2U37_02325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_02330 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U37_02340 ENOG4105VRX Protein slyX homolog C2U37_02345 ENOG4108YZY peptidylprolyl cis-trans isomerase C2U37_02350 ENOG4105VKU nucleicacid-binding protein C2U37_02360 ENOG4107R88 Chemotaxis protein (CheV) C2U37_02365 ENOG4105DNZ Alpha Beta Hydrolase C2U37_02375 ENOG4105YP7 UPF0270 protein C2U37_02380 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) C2U37_02395 ENOG4108UKZ OsmC family C2U37_02400 ENOG4107RYR Transcriptional regulator, Crp Fnr family C2U37_02405 ENOG4105DHI Methyltransferase C2U37_02415 ENOG4105BZU Histidine kinase C2U37_02420 ENOG4105D8G Major Facilitator superfamily C2U37_02445 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related C2U37_02450 ENOG41090JE Utilization Protein C2U37_02460 ENOG4105EHG Permease protein C2U37_02475 ENOG4105C6Y Udp-glucose 6-dehydrogenase C2U37_02485 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C2U37_02495 ENOG4105CKK Glycosyl transferase, family 2 C2U37_02505 ENOG4105E4C Lytic transglycosylase catalytic C2U37_02595 ENOG4105D07 Signal peptide peptidase, SppA C2U37_02610 ENOG4105CAR Terminase, large subunit C2U37_02660 ENOG4108RAV Conserved protein C2U37_02665 ENOG4105KT5 UmuD protein C2U37_02670 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U37_02835 ENOG4107R08 Integrase C2U37_02840 ENOG4105C5H ABC transporter C2U37_02850 ENOG4105C7N Xanthine uracil vitamin C permease C2U37_02855 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) C2U37_02860 ENOG4108S0S Nucleotidyl transferase C2U37_02865 ENOG4105EHM Aminoglycoside phosphotransferase C2U37_02870 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C2U37_02880 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2U37_02885 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C2U37_02890 ENOG4105NWN ApaG protein C2U37_02895 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2U37_02905 ENOG4105DEN Luciferase family C2U37_02910 ENOG4108ESY Metal dependent phosphohydrolase C2U37_02915 ENOG4105DWD nucleoside recognition domain protein C2U37_02920 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C2U37_02925 ENOG4105K46 50S ribosomal protein l27 C2U37_02930 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C2U37_02935 ENOG4105EAH synthase C2U37_02945 ENOG4105EPW hflc protein C2U37_02950 ENOG4107QJR hflk protein C2U37_02955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2U37_02960 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2U37_02965 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C2U37_02970 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C2U37_02975 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2U37_02980 ENOG4105K8N protein family UPF0079, ATPase C2U37_02985 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C2U37_03005 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U37_03010 ENOG4108UMI ABC transporter, permease C2U37_03015 ENOG4105D01 (LipO)protein C2U37_03020 ENOG4105MDZ Transcriptional activator rfaH C2U37_03025 ENOG4107SDU Methyl-accepting chemotaxis C2U37_03030 ENOG4105BZU Histidine kinase C2U37_03035 ENOG4105BZU Histidine kinase C2U37_03050 ENOG4105BZU Histidine kinase C2U37_03070 ENOG4108Q67 UPF0319 protein C2U37_03075 ENOG4105EXG Transcriptional regulator C2U37_03085 ENOG4107QWK SAICAR synthetase C2U37_03090 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U37_03095 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U37_03100 ENOG4105RH4 Glycine cleavage system transcriptional repressor C2U37_03105 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U37_03110 ENOG4105XWI UPF0304 protein C2U37_03115 ENOG4105PQ6 UPF0208 membrane protein C2U37_03120 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2U37_03125 ENOG4105C6K Malic enzyme C2U37_03130 ENOG4108ZP8 Acetolactate synthase small subunit C2U37_03135 ENOG4105C7K acetolactate synthase C2U37_03150 ENOG4105YVM Phosphoesterase, PA-phosphatase related C2U37_03160 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2U37_03170 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U37_03175 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U37_03190 ENOG4105DP9 ABC transporter C2U37_03195 ENOG4106SMU thiamine transporter membrane protein C2U37_03200 ENOG4107T0D ABC, transporter C2U37_03205 ENOG4108IAB Phoh family C2U37_03255 ENOG4107QWG 2-Nitropropane dioxygenase C2U37_03280 ENOG4105VNT transposase (IS4 family) protein C2U37_03285 ENOG4105E0F Histidine kinase C2U37_03290 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U37_03295 ENOG4105DJY efflux transporter, rnd family, mfp subunit C2U37_03300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U37_03310 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase C2U37_03330 ENOG4106B0W Curli production assembly transport component CsgG C2U37_03340 ENOG4107Y60 (LipO)protein C2U37_03345 ENOG4105BZU Histidine kinase C2U37_03350 ENOG4105C1J atp-dependent rna helicase C2U37_03360 ENOG4106AXJ AraC family transcriptional regulator C2U37_03390 ENOG4108J1Q C2U37_03395 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U37_03400 ENOG4105DWY Agmatine deiminase C2U37_03415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U37_03420 ENOG4108MJ3 acetyltransferase C2U37_03425 ENOG4105C09 Bile acid C2U37_03445 ENOG4105BZU Histidine kinase C2U37_03450 ENOG4105EV2 VWA domain protein interacting with AAA ATPase C2U37_03465 ENOG41080E2 ribosomal-protein-alanine acetyltransferase C2U37_03475 ENOG4108IQE Amp-dependent synthetase and ligase C2U37_03515 ENOG4107SQD Transcriptional regulator, GntR family C2U37_03530 ENOG4105C8J )-transporter C2U37_03535 ENOG4105C8J )-transporter C2U37_03550 ENOG4108K4B hydrolase C2U37_03565 ENOG4105EW9 transcriptional regulator AsnC family C2U37_03580 ENOG4105K56 Transcriptional regulator C2U37_03585 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C2U37_03605 ENOG4105E0X reductase C2U37_03615 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C2U37_03620 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) C2U37_03630 ENOG4105VNT transposase (IS4 family) protein C2U37_03635 ENOG4105DSB aldose 1-epimerase C2U37_03640 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C2U37_03645 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_03720 ENOG4105UFD tol-pal system protein YbgF C2U37_03725 ENOG4105KCK Peptidoglycan-associated lipoprotein C2U37_03730 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C2U37_03740 ENOG4105M8F Biopolymer transport protein exbD tolR C2U37_03745 ENOG4105E02 MotA TolQ exbB proton channel C2U37_03750 ENOG4107YD3 Thioesterase C2U37_03755 ENOG4105KJB cyd operon protein YbgE C2U37_03765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U37_03770 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U37_03775 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C2U37_03780 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C2U37_03790 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2U37_03795 ENOG41083X2 DNA polymerase III, epsilon subunit C2U37_03800 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr C2U37_03815 ENOG4105E39 Enoyl-CoA hydratase C2U37_03820 ENOG4106WH9 Protein of unknown function (DUF2753) C2U37_03830 ENOG4107QSI ABC, transporter C2U37_03840 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U37_03845 ENOG4105C1J atp-dependent rna helicase C2U37_03850 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C2U37_03880 ENOG4105EJG cellulose synthase C2U37_03885 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) C2U37_03890 ENOG4107EEX Cellulose synthase regulator protein C2U37_03895 ENOG4107QZ7 Cellulose synthase catalytic subunit C2U37_03900 ENOG4105UTS cellulose synthase operon protein YhjQ C2U37_03910 ENOG4105D1V cellulose synthase operon protein YhjU C2U37_03915 ENOG4105CGF Aromatic amino acid aminotransferase C2U37_03935 ENOG4105G0K glycine radical enzyme YjjI family C2U37_03960 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_03965 ENOG4108M1A Chitin-binding protein C2U37_03970 ENOG4107R11 Transcriptional regulator C2U37_03975 ENOG4108IJ6 ABC transporter C2U37_03980 ENOG4105ECW sulfate abc transporter C2U37_03985 ENOG4108I5D sulfate abc transporter C2U37_03995 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2U37_04025 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) C2U37_04030 ENOG4105D3G Pseudouridine synthase C2U37_04040 ENOG4105BZU Histidine kinase C2U37_04050 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C2U37_04055 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C2U37_04065 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 C2U37_04070 ENOG4108IJ0 Aspartate ammonia-lyase C2U37_04075 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2U37_04080 ENOG4105D9M gamma-glutamylcysteine synthetase C2U37_04090 ENOG4105W39 Membrane C2U37_04105 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C2U37_04125 ENOG4105DP0 ferredoxin-NADP reductase C2U37_04130 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C2U37_04135 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C2U37_04140 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C2U37_04145 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2U37_04150 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U37_04155 ENOG4107YB6 acetyltransferase, (GNAT) family C2U37_04165 ENOG4105C2N RNA methyltransferase TrmH family group 3 C2U37_04170 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C2U37_04175 ENOG4106TD9 Diguanylate cyclase C2U37_04180 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C2U37_04190 ENOG4108YZA Nitrogen regulatory protein pii C2U37_04195 ENOG4105C4K Nad synthetase C2U37_04230 ENOG4106855 Competence protein C2U37_04235 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C2U37_04240 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C2U37_04245 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C2U37_04250 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2U37_04255 ENOG4105DTN riboflavin biosynthesis protein ribF C2U37_04260 ENOG4105CJR Integral membrane protein (MviN C2U37_04265 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C2U37_04270 ENOG41080HT Transcriptional regulator, arsr family C2U37_04275 ENOG41063Z6 transcriptional regulator, lysR family C2U37_04285 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C2U37_04290 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C2U37_04295 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C2U37_04300 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase C2U37_04305 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2U37_04320 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C2U37_04325 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C2U37_04330 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C2U37_04335 ENOG4105K5M 30s ribosomal protein S16 C2U37_04340 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C2U37_04345 ENOG4106KVJ cytochrome C assembly protein C2U37_04350 ENOG4108JU6 CBS domain protein C2U37_04360 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C2U37_04365 ENOG4108UV7 flagellar protein motX C2U37_04375 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2U37_04380 ENOG4105DMR ABC, transporter C2U37_04385 ENOG4105GBT ABC transporter C2U37_04390 ENOG4106TNF Periplasmic binding protein C2U37_04395 ENOG4105E5Z arginine transporter ATP-binding subunit C2U37_04400 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) C2U37_04405 ENOG4105EZR dyp-type peroxidase family protein C2U37_04410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U37_04420 ENOG4107QKW extracellular solute-binding protein family 1 C2U37_04425 ENOG4108YZA Nitrogen regulatory protein pii C2U37_04430 ENOG4108YZN class I peptide chain release factor C2U37_04440 ENOG4105D9N nucleoside C2U37_04445 ENOG4105HEI LysR family (Transcriptional regulator C2U37_04460 ENOG4105BZW Glycerate kinase C2U37_04465 ENOG4107QQ0 gntp family C2U37_04470 ENOG4107VHA regulatoR C2U37_04475 ENOG4105XTV UPF0231 protein C2U37_04495 ENOG4105VZ9 UPF0235 protein C2U37_04500 ENOG4108VIA integral membrane protein C2U37_04505 ENOG4105II7 pyrroline-5-carboxylate reductase C2U37_04510 ENOG4105DFA alanine racemase domain protein C2U37_04515 ENOG4105CZX twitching motility protein C2U37_04520 ENOG4105CZX twitching motility protein C2U37_04525 ENOG4105D1Q UPF0246 protein C2U37_04530 ENOG4105C1J atp-dependent rna helicase C2U37_04535 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) C2U37_04540 ENOG4105CWM branched-chain amino acid transport system II carrier protein C2U37_04555 ENOG4105MYN Zinc uptake regulation protein C2U37_04560 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U37_04575 ENOG4105K70 DNA-binding protein C2U37_04580 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor C2U37_04590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C2U37_04605 ENOG4105EAC phosphoserine phosphatase C2U37_04615 ENOG4105BZU Histidine kinase C2U37_04620 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C2U37_04625 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C2U37_04630 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C2U37_04635 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C2U37_04645 ENOG4105D9N nucleoside C2U37_04650 ENOG4105EYA deoxyribonuclease C2U37_04665 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2U37_04670 ENOG4105BZU Histidine kinase C2U37_04690 ENOG4108K5H permease YjgP YjgQ family protein C2U37_04695 ENOG4108M8S permease YjgP YjgQ family protein C2U37_04700 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U37_04705 ENOG4105MYG DNA polymerase iii, chi subunit C2U37_04710 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C2U37_04720 ENOG4106W5V Membrane C2U37_04725 ENOG41061WM D-Alanyl-D-Alanine C2U37_04760 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C2U37_04765 ENOG4105CFH Aspartokinase C2U37_04770 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U37_04775 ENOG4105Y3E Modulates RecA activity (By similarity) C2U37_04780 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C2U37_04785 ENOG4107TH8 cina domain protein C2U37_04795 ENOG4105D70 Integrase catalytic subunit C2U37_04800 ENOG4105F5W AtP-binding protein C2U37_04825 ENOG4105DZR Type I site-specific deoxyribonuclease C2U37_04850 ENOG4105EKX Restriction modification system DNA (Specificity C2U37_04855 ENOG4105CVR type I restriction-modification system C2U37_04890 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C2U37_04920 ENOG4105DR5 peptidase C2U37_04940 ENOG4105NXV High-affinity zinc uptake system protein C2U37_04945 ENOG4105FDK ABC transporter C2U37_04950 ENOG4105FAV ABC, transporter C2U37_04955 ENOG4105ETT transcriptional Regulator, LysR family C2U37_04965 ENOG4108RG0 uracil-dna glycosylase C2U37_04970 ENOG4105FR1 rard protein C2U37_04975 ENOG41082IR Excinuclease ABC C subunit domain protein C2U37_04990 ENOG41087YS Phage shock protein A C2U37_04995 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase C2U37_05015 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U37_05025 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2U37_05070 ENOG4105F2I Transposase C2U37_05080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U37_05085 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U37_05090 ENOG4105DSW Fusaric acid resistance protein C2U37_05095 ENOG4105Y49 secretion protein, HlyD family C2U37_05115 ENOG4105IPS esterase C2U37_05125 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C2U37_05130 ENOG4108SX3 cytoplasmic protein C2U37_05135 ENOG41087AY ADP-Ribose pyrophosphatase C2U37_05140 ENOG4105DFG type I secretion outer membrane protein C2U37_05145 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C2U37_05150 ENOG4105D1S lipid A biosynthesis C2U37_05155 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic C2U37_05160 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C2U37_05165 ENOG4105VJY transcriptional regulator C2U37_05170 ENOG4105NNS Autoinducer synthesis protein C2U37_05175 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C2U37_05180 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) C2U37_05185 ENOG4105CTS PTS system mannitol-specific C2U37_05190 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C2U37_05195 ENOG4105E61 Mannitol repressor protein C2U37_05220 ENOG4108UPT UPF0178 protein C2U37_05235 ENOG4105D9N nucleoside C2U37_05240 ENOG4105C1J atp-dependent rna helicase C2U37_05260 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C2U37_05265 ENOG4105E4F Isochorismate synthase C2U37_05270 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C2U37_05275 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C2U37_05280 ENOG4108IPT Naphthoate synthase C2U37_05285 ENOG4105DNI Converts SHCHC to OSB (By similarity) C2U37_05290 ENOG4105CEY Amp-dependent synthetase and ligase C2U37_05295 ENOG4107MM9 BNR Asp-box repeat-containing protein C2U37_05300 ENOG4108UB4 uncharacterized protein ygjQ C2U37_05305 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U37_05315 ENOG4107IFA Lipase (EC 3.1.1.3) C2U37_05345 ENOG4108IQK o-acetylhomoserine C2U37_05355 ENOG4108I6A alcohol dehydrogenase C2U37_05370 ENOG4105EMU Dehydrogenase C2U37_05390 ENOG4105KT7 mgtC SapB transporter C2U37_05405 ENOG4105E0M Sulfatase C2U37_05410 ENOG4108YXU transcriptional regulator AsnC family C2U37_05420 ENOG4105CVG Homoserine O-transsuccinylase C2U37_05430 ENOG4108I62 cina-like protein C2U37_05435 ENOG4107K5X Membrane-bound metal-dependent hydrolase C2U37_05445 ENOG410667J hydrolase C2U37_05450 ENOG4108Z86 Glutamine amidotransferase C2U37_05460 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant C2U37_05465 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_05475 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C2U37_05480 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C2U37_05490 ENOG4105XQ6 frataxin-like protein C2U37_05495 ENOG4106CJB Phospholipase Carboxylesterase C2U37_05500 ENOG4107T0K Adenylate cyclase C2U37_05510 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C2U37_05515 ENOG41076E6 Uroporphyrinogen-III Synthase C2U37_05520 ENOG4105ECF c-methyltransferase C2U37_05525 ENOG410601J HemY protein C2U37_05530 ENOG4105KRS Proteinase inhibitor C2U37_05535 ENOG4105CBT Fructose-1,6-bisphosphatase C2U37_05545 ENOG4105DMQ Methyltransferase C2U37_05555 ENOG4105E0K tonB-dependent siderophore receptor C2U37_05570 ENOG4105KVH Transcriptional regulator C2U37_05575 ENOG4105N0V mono-oxygenase ydhR C2U37_05585 ENOG4108TPP exopolysaccharide synthesis C2U37_05590 ENOG4105BZU Histidine kinase C2U37_05595 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) C2U37_05620 ENOG4105F2I Transposase C2U37_05630 ENOG4105D41 biosynthesis protein thiH C2U37_05635 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C2U37_05645 ENOG4105D06 uba thif-type nad fad binding protein C2U37_05650 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C2U37_05655 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C2U37_05670 ENOG4105ETX regulatoR C2U37_05680 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C2U37_05690 ENOG4105C3R Methionine synthase C2U37_05695 ENOG4105EEQ Na H antiporter C2U37_05715 ENOG4105CGZ zinc metallopeptidase C2U37_05725 ENOG4105CSH Transporter C2U37_05740 ENOG4105D1U peptidase U62 modulator of DNA gyrase C2U37_05750 ENOG4105QD6 exported protein C2U37_05755 ENOG4105C03 ribonuclease C2U37_05760 ENOG4108Z03 MAF-like protein C2U37_05765 ENOG4105VQ7 Rod shape-determining protein MreD C2U37_05770 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C2U37_05775 ENOG4105DFF Rod shape-determining protein mreb C2U37_05820 ENOG4105D7Q type ii secretion system C2U37_05840 ENOG4105GVR general secretion pathway protein D C2U37_05885 ENOG4105EWV Sodium calcium exchanger membrane region C2U37_05890 ENOG4105C84 Histidine ammonia-lyase C2U37_05895 ENOG4105CGP Urocanate hydratase C2U37_05900 ENOG41088SP formiminoglutamate hydrolase C2U37_05905 ENOG4105CI2 imidazolone-5-propionate hydrolase C2U37_05910 ENOG4105CZE histidine utilization repressor C2U37_05915 ENOG41077A9 carbonic anhydrase C2U37_05920 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U37_05925 ENOG4105CRP Part of the ABC transporter FtsEX involved in C2U37_05930 ENOG4105CAK Cell division ATP-binding protein ftsE C2U37_05935 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C2U37_05940 ENOG4106H78 methyltransferase C2U37_05950 ENOG4108Y73 Membrane C2U37_05955 ENOG4105EJ2 Transcriptional regulator C2U37_05965 ENOG4107RZC phospholipase d C2U37_05970 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C2U37_05980 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C2U37_05990 ENOG41076UM multiple antibiotic resistance (MarC)-related protein C2U37_05995 ENOG4105VVZ metal-binding protein C2U37_06010 ENOG4105CR8 Transcriptional regulator C2U37_06025 ENOG4107FS9 Membrane C2U37_06045 ENOG4105CUG Oligopeptidase b C2U37_06060 ENOG4105EMU Dehydrogenase C2U37_06070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C2U37_06130 ENOG4108ZT0 50S ribosomal protein l17 C2U37_06135 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U37_06140 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C2U37_06145 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C2U37_06150 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C2U37_06155 ENOG41067V7 50S ribosomal protein L36 C2U37_06160 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2U37_06165 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C2U37_06170 ENOG4105VPB 50S ribosomal protein L30 C2U37_06175 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C2U37_06180 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C2U37_06185 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C2U37_06190 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C2U37_06195 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C2U37_06200 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C2U37_06205 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C2U37_06210 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C2U37_06215 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C2U37_06220 ENOG41083MP 50s ribosomal protein l29 C2U37_06225 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C2U37_06230 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C2U37_06235 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C2U37_06240 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C2U37_06245 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C2U37_06250 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C2U37_06255 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C2U37_06260 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C2U37_06265 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C2U37_06275 ENOG4105E0F Histidine kinase C2U37_06280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U37_06285 ENOG4108RRZ Transcription elongation factor GreB C2U37_06290 ENOG4105BZM domain protein C2U37_06305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C2U37_06310 ENOG4105MJ2 Competence protein C2U37_06315 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) C2U37_06320 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C2U37_06325 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) C2U37_06330 ENOG4107YZP Rhodanese domain protein C2U37_06335 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2U37_06340 ENOG41063SB peptidase C2U37_06350 ENOG4105DIQ Transcriptional regulator C2U37_06365 ENOG4108UHU Aldolase C2U37_06370 ENOG4105C01 Dihydroxy-acid dehydratase C2U37_06375 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family C2U37_06380 ENOG4105C6Z Gluconate C2U37_06385 ENOG4105JIM Phosphatidylserine synthase C2U37_06390 ENOG4105CB5 ATP-dependent DNA helicase recG C2U37_06400 ENOG4105SUU thioesterase domain C2U37_06410 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C2U37_06415 ENOG4107S2Z UPF0761 membrane protein C2U37_06425 ENOG4105C5F glutamine synthetase C2U37_06435 ENOG4105CUX Signal transduction histidine kinase C2U37_06440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_06445 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C2U37_06450 ENOG4105D4P Coproporphyrinogen iii oxidase C2U37_06455 ENOG4105XCT Protein of unknown function (DUF2489) C2U37_06460 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) C2U37_06465 ENOG4106RE7 Cytochrome C2U37_06470 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C2U37_06480 ENOG4105E2X shikimate dehydrogenase C2U37_06485 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C2U37_06490 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U37_06495 ENOG4108WI1 Dna topoisomerase C2U37_06500 ENOG4108RPN Protein smg homolog C2U37_06505 ENOG4105C79 DNA protecting protein DprA C2U37_06515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2U37_06520 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C2U37_06525 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2U37_06530 ENOG4105C1A potassium transporter peripheral membrane C2U37_06535 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C2U37_06540 ENOG4105CGY Dna recombination protein C2U37_06570 ENOG4108MGF sugar kinase C2U37_06575 ENOG4107R11 Transcriptional regulator C2U37_06580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U37_06585 ENOG4105C26 Dehydrogenase C2U37_06595 ENOG4108JCI Transcriptional regulator C2U37_06600 ENOG4105C26 Dehydrogenase C2U37_06605 ENOG4105FR1 rard protein C2U37_06610 ENOG4105ECQ AraC Family Transcriptional Regulator C2U37_06620 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) C2U37_06640 ENOG41061EV selenium-binding protein YdfZ C2U37_06655 ENOG4105HEI LysR family (Transcriptional regulator C2U37_06660 ENOG4108UK5 Transposase C2U37_06665 ENOG4105C4R Atp-dependent dna helicase C2U37_06670 ENOG4105DIH basic membrane C2U37_06675 ENOG4108JQ9 ABC transporter C2U37_06680 ENOG4105UIB (ABC) transporter C2U37_06695 ENOG4105CC0 LysR family Transcriptional regulator C2U37_06705 ENOG4105C4W S-formylglutathione hydrolase C2U37_06725 ENOG4105DHU Bile acid C2U37_06730 ENOG4105E5D amino acid C2U37_06735 ENOG4108Y51 tRNA-binding protein C2U37_06740 ENOG4105E5D amino acid C2U37_06745 ENOG4105FK9 beta-D-galactosidase beta subunit C2U37_06750 ENOG4105CNT hydrolase family 2 C2U37_06755 ENOG4105CQ4 Transcriptional regulator C2U37_06795 ENOG4108Z0R Transferase C2U37_06800 ENOG4105C2M dna polymerase I C2U37_06805 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain C2U37_06810 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) C2U37_06820 ENOG4105D7W serine acetyltransferase C2U37_06825 ENOG41076HS cation diffusion facilitator family transporter C2U37_06830 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U37_06835 ENOG4105E0F Histidine kinase C2U37_06840 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C2U37_06845 ENOG4107R73 Mate efflux family protein C2U37_06860 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2U37_06865 ENOG4105E55 glycerol-3-phosphate acyltransferase C2U37_06870 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) C2U37_06875 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C2U37_06880 ENOG4105X6C Flagellar basal body-associated protein FliL C2U37_06900 ENOG4105DIQ Transcriptional regulator C2U37_06925 ENOG4108XNZ glycosyl transferase C2U37_06930 ENOG4105W1T Glycosyl Transferase C2U37_06945 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C2U37_06950 ENOG41062JF Transcriptional regulator C2U37_06955 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C2U37_06960 ENOG4105CPQ Dehydrogenase C2U37_06965 ENOG4105MPD Cytochrome C2U37_06970 ENOG4105BZU Histidine kinase C2U37_06975 ENOG4105C4R Atp-dependent dna helicase C2U37_06980 ENOG4105C9B Cysteine desulfurase C2U37_06985 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) C2U37_06990 ENOG4105CUZ uba thif-type nad fad binding protein C2U37_07035 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C2U37_07040 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C2U37_07045 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C2U37_07050 ENOG4105FCD Major Facilitator C2U37_07055 ENOG4105DY9 regulatoR C2U37_07060 ENOG4108HRK Histidine kinase C2U37_07080 ENOG4105F2I Transposase C2U37_07100 ENOG4108NIW Leucine export protein LeuE C2U37_07105 ENOG4105EU0 Major facilitator Superfamily C2U37_07110 ENOG4105CBX hi0933 family C2U37_07115 ENOG41090A1 ferritin C2U37_07120 ENOG4105BZU Histidine kinase C2U37_07125 ENOG4105RKW reductase (By C2U37_07135 ENOG4108M6U Universal stress protein A C2U37_07165 ENOG4105EMK carboxylate amino acid amine transporter C2U37_07175 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) C2U37_07180 ENOG4105DKP glycosyl transferase, family 9 C2U37_07200 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C2U37_07205 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U37_07210 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase C2U37_07215 ENOG4108EUD Lysophospholipase C2U37_07220 ENOG4105DQF Hydrolase C2U37_07250 ENOG4105Y7M Transcriptional regulator, TetR family C2U37_07255 ENOG410624X efflux transporter, rnd family, mfp subunit C2U37_07260 ENOG4105BZS acriflavin resistance protein C2U37_07265 ENOG4105BZU Histidine kinase C2U37_07270 ENOG4105DC8 reductase C2U37_07280 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C2U37_07285 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C2U37_07295 ENOG4105C08 Histidine kinase C2U37_07300 ENOG4105EEX Two component transcriptional regulator (Winged helix family C2U37_07305 ENOG4105C2C drug resistance transporter, Bcr CflA C2U37_07320 ENOG4105JKW Valine--pyruvate aminotransferase C2U37_07325 ENOG4108ZNX Heat shock protein C2U37_07330 ENOG4108ZNX Heat shock protein C2U37_07335 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein C2U37_07340 ENOG4108R6W Transcriptional regulator, ARAC family C2U37_07345 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U37_07350 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2U37_07355 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2U37_07360 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C2U37_07365 ENOG4105EAB amino acid AbC transporter C2U37_07370 ENOG4105E5Q amino acid AbC transporter C2U37_07375 ENOG4105CDA abc transporter atp-binding protein C2U37_07380 ENOG4105VG0 50S ribosomal protein l34 C2U37_07385 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C2U37_07390 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C2U37_07395 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2U37_07400 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C2U37_07405 ENOG4105S6R Iron-hydroxamate transporter permease subunit C2U37_07410 ENOG4105J76 Periplasmic binding protein C2U37_07415 ENOG4105E0A ABC, transporter C2U37_07420 ENOG4105IBP Cyclic peptide transporter C2U37_07425 ENOG4105E0K tonB-dependent siderophore receptor C2U37_07430 ENOG4105QTB Flavodoxin C2U37_07435 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C2U37_07440 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C2U37_07445 ENOG4107QJE Chromosome Partitioning Protein C2U37_07450 ENOG4105FA0 parb-like partition protein C2U37_07460 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) C2U37_07465 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U37_07470 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U37_07475 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U37_07480 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C2U37_07485 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C2U37_07490 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C2U37_07495 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C2U37_07500 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C2U37_07505 ENOG4105CT7 inner membrane cred family protein C2U37_07515 ENOG4105EB3 Histidine kinase C2U37_07520 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U37_07525 ENOG410804X Transcriptional regulator C2U37_07530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2U37_07605 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 C2U37_07610 ENOG4107QP8 phosphohexose isomerase C2U37_07615 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2U37_07625 ENOG410787A Pts system, glucitol sorbitol-specific C2U37_07630 ENOG4105DZY Pts system, glucitol sorbitol-specific C2U37_07635 ENOG4105VI0 Pts system, glucitol sorbitol-specific C2U37_07640 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase C2U37_07650 ENOG410804X Transcriptional regulator C2U37_07655 ENOG4105C2X Arabinose 5-phosphate isomerase C2U37_07665 ENOG4105VJY transcriptional regulator C2U37_07685 ENOG4109015 Biopolymer transport protein exbD tolR C2U37_07690 ENOG410822N TonB family C2U37_07725 ENOG4105DZC cytosine deaminase C2U37_07730 ENOG4105WMR Protein CrcB homolog C2U37_07740 ENOG4105JC1 sterol-binding domain protein C2U37_07745 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C2U37_07750 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C2U37_07755 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) C2U37_07760 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C2U37_07765 ENOG4105F8V Hydrolase, tatD family C2U37_07770 ENOG4105D52 delta-aminolevulinic acid dehydratase C2U37_07775 ENOG4105DGW oligopeptidase A C2U37_07780 ENOG4105BZU Histidine kinase C2U37_07785 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) C2U37_07795 ENOG4105C9X ppx gppa phosphatase C2U37_07800 ENOG4105C1J atp-dependent rna helicase C2U37_07805 ENOG4105K63 Thioredoxin C2U37_07810 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C2U37_07820 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C2U37_07825 ENOG4107QK7 reductase C2U37_07830 ENOG4105W0Z cytoplasmic protein C2U37_07845 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) C2U37_07860 ENOG4108IV0 ABC, transporter C2U37_07865 ENOG4105C0Z ABC transporter C2U37_07870 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U37_07875 ENOG4105C32 Amino acid ABC transporter (Permease) C2U37_07880 ENOG4105CP9 extracellular ligand-binding receptor C2U37_07885 ENOG4105ETE Transcriptional regulator (LacI family C2U37_07890 ENOG4108JUA Transcriptional regulator C2U37_07895 ENOG4105CNW domain protein C2U37_07900 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase C2U37_07910 ENOG4105HEE Binding Domain protein C2U37_07920 ENOG4105C0F tryptophanase EC 4.1.99.1 C2U37_07925 ENOG4105CIC tryptophan-specific transport protein C2U37_07930 ENOG4105CIC tryptophan-specific transport protein C2U37_07955 ENOG4105F2I Transposase C2U37_07960 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C2U37_07965 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C2U37_07970 ENOG4108R3E Dna-3-methyladenine glycosylase i C2U37_07975 ENOG4105D3W isochorismatase C2U37_07985 ENOG4108ZG0 Ompa motb domain protein C2U37_08010 ENOG4105M4H endoribonuclease L-psp C2U37_08015 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C2U37_08030 ENOG4105E0F Histidine kinase C2U37_08035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U37_08040 ENOG4105CHU acetyl-coa acetyltransferase C2U37_08045 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U37_08050 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U37_08055 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) C2U37_08060 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C2U37_08065 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C2U37_08070 ENOG4108RR8 protoporphyrinogen oxidase C2U37_08095 ENOG4105CD5 CoA-binding domain protein C2U37_08105 ENOG4105EMY transcriptional regulator C2U37_08110 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2U37_08115 ENOG4107QP8 phosphohexose isomerase C2U37_08125 ENOG4105D64 Mechanosensitive ion channel C2U37_08135 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C2U37_08140 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C2U37_08145 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C2U37_08150 ENOG4105W5Q DNA repair protein (RadC C2U37_08155 ENOG4105KDC 50s ribosomal protein l28 C2U37_08160 ENOG4105W0E 50S ribosomal protein L33 C2U37_08170 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C2U37_08175 ENOG4108MJ5 VirK protein C2U37_08180 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C2U37_08185 ENOG4105M5K heptosyltransferase C2U37_08190 ENOG4106WTF Glycosyl transferase, family 2 C2U37_08195 ENOG4105XA0 heptosyltransferase ii C2U37_08200 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C2U37_08210 ENOG4105DSJ YicC domain protein C2U37_08215 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C2U37_08220 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C2U37_08240 ENOG4105PC1 Conserved Protein C2U37_08250 ENOG4105E27 serine threonine protein kinase C2U37_08255 ENOG4108Z33 Thiol disulfide Interchange Protein C2U37_08260 ENOG4105S7S phosphonate abc transporter C2U37_08265 ENOG4108VA1 ABC transporter C2U37_08270 ENOG4105EHI Phosphonate ABC transporter, periplasmic C2U37_08280 ENOG4108RWI nicotinamidase C2U37_08290 ENOG4105EWC Purine nucleoside phosphorylase C2U37_08295 ENOG4106HNH Acyl-transferase C2U37_08300 ENOG4106HNH Acyl-transferase C2U37_08305 ENOG4105C0P Mg chelatase subunit ChlI C2U37_08320 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit C2U37_08325 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2U37_08330 ENOG4105C01 Dihydroxy-acid dehydratase C2U37_08335 ENOG4105C7B Threonine dehydratase C2U37_08340 ENOG4105UYK outer membrane protein a C2U37_08350 ENOG4105XEA Tetr family transcriptional regulator C2U37_08355 ENOG4105C25 Primosomal protein n' C2U37_08360 ENOG4105VFB Binds the 23S rRNA (By similarity) C2U37_08365 ENOG4105CGD Nad-dependent epimerase dehydratase C2U37_08370 ENOG4105C6K Malic enzyme C2U37_08380 ENOG4105JJR Histidine kinase C2U37_08390 ENOG4107EXC regulatoR C2U37_08395 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) C2U37_08410 ENOG4107R28 alpha amylase, catalytic region C2U37_08425 ENOG4105R8A Heat shock protein C2U37_08430 ENOG4105C5I Dehydrogenase C2U37_08435 ENOG4108RH0 Crea protein C2U37_08450 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C2U37_08455 ENOG4105CFQ glutamine synthetase C2U37_08460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2U37_08470 ENOG4108HM4 ABC transporter C2U37_08475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U37_08480 ENOG4105F38 ABC transporter, permease C2U37_08485 ENOG4105D38 putrescine abc transporter C2U37_08490 ENOG4108RPX mosc domain containing protein C2U37_08505 ENOG4108VUY thioesterase Superfamily protein C2U37_08510 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U37_08515 ENOG4105N7H Cytochrome C2U37_08520 ENOG4105CNG UPF0061 protein C2U37_08530 ENOG4105EX9 Membrane C2U37_08535 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C2U37_08540 ENOG4105CJW magnesium transporter C2U37_08545 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U37_08550 ENOG4107V9H nitrite transporter C2U37_08555 ENOG4105WZK nitrite reductase NADPH small subunit C2U37_08560 ENOG4107QZF nitrite reductase NADPH large subunit C2U37_08565 ENOG4107QWP ABC-2 type transporter C2U37_08570 ENOG4107QWP ABC-2 type transporter C2U37_08575 ENOG4105CJ1 ABC, transporter C2U37_08580 ENOG4105D0S secretion protein (HlyD C2U37_08595 ENOG4105C57 major facilitator superfamily C2U37_08600 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C2U37_08605 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C2U37_08615 ENOG4105C75 arginyL-tRNA synthetase C2U37_08625 ENOG4105K6V RNA polymerase C2U37_08630 ENOG4108NIX Factor ChrR C2U37_08635 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2U37_08640 ENOG4105CPC Aldo Keto reductase C2U37_08645 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C2U37_08650 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C2U37_08655 ENOG4105F0Z galactose-1-phosphate uridylyltransferase C2U37_08660 ENOG4105CMR udp-glucose 4-epimerase C2U37_08665 ENOG41060NJ transcriptional regulator C2U37_08670 ENOG4105CNT hydrolase family 2 C2U37_08685 ENOG4107SDZ Galactoside transport system permease protein mglC C2U37_08690 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_08705 ENOG4105C5B carbamate kinase C2U37_08710 ENOG4105DBV ornithine carbamoyltransferase C2U37_08715 ENOG4105CSX c4-dicarboxylate anaerobic carrier C2U37_08720 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) C2U37_08725 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) C2U37_08730 ENOG4105CXT aspartate transcarbamylase C2U37_08755 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_08765 ENOG4105QNF Outer membrane lipoprotein C2U37_08770 ENOG4105CF7 AraC family transcriptional regulator C2U37_08775 ENOG4108I6A alcohol dehydrogenase C2U37_08780 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U37_08785 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U37_08790 ENOG4105VNT transposase (IS4 family) protein C2U37_08795 ENOG4105WWK YheO domain protein C2U37_08800 ENOG4105CEM UPF0597 protein C2U37_08805 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C2U37_08810 ENOG4105C34 Pseudouridine synthase C2U37_08815 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C2U37_08820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U37_08825 ENOG4107T8T UPF0173 metal-dependent hydrolase C2U37_08830 ENOG4105CU9 asparagine synthetase A C2U37_08835 ENOG4108VVK transcriptional Regulator, AsnC C2U37_08845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U37_08850 ENOG410642E Short chain dehydrogenase C2U37_08865 ENOG4107WP9 Histidine kinase C2U37_08875 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_08885 ENOG4108UQ5 membrane protein YcdZ C2U37_08895 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C2U37_08900 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) C2U37_08915 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U37_08920 ENOG4105IFJ Histidine kinase C2U37_08930 ENOG4107QY8 reductase C2U37_08935 ENOG4105CUW cytochrome C-TYPE protein C2U37_08940 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U37_08950 ENOG4107ZYR domain protein C2U37_08955 ENOG4105D4A Cell wall formation (By similarity) C2U37_08960 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C2U37_08965 ENOG4105CS9 pantothenic acid kinase C2U37_08980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U37_08990 ENOG4105PM1 preprotein translocase subunit SecE C2U37_08995 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C2U37_09000 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C2U37_09005 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C2U37_09010 ENOG4108VZM 50s ribosomal protein L10 C2U37_09015 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C2U37_09020 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U37_09025 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U37_09030 ENOG4105WWK YheO domain protein C2U37_09035 ENOG4105KME endoribonuclease L-psp C2U37_09040 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) C2U37_09050 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) C2U37_09055 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C2U37_09060 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C2U37_09065 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C2U37_09070 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U37_09075 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C2U37_09105 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C2U37_09110 ENOG4105C7N Xanthine uracil vitamin C permease C2U37_09115 ENOG4105CMT Dihydroxyacetone kinase C2U37_09120 ENOG4108UTZ Dihydroxyacetone kinase C2U37_09150 ENOG4105IPI Membrane C2U37_09175 ENOG4105CH6 catalase C2U37_09180 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2U37_09200 ENOG4105BZU Histidine kinase C2U37_09210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U37_09220 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component C2U37_09245 ENOG4105CWB LysR family transcriptional Regulator C2U37_09255 ENOG4105C2I pirin domain protein C2U37_09260 ENOG4108VBZ doxx family C2U37_09265 ENOG4105DSY exodeoxyribonuclease V, gamma C2U37_09270 ENOG4107QKA exodeoxyribonuclease V beta C2U37_09275 ENOG4107QYX exodeoxyribonuclease v alpha C2U37_09285 ENOG4105F2I Transposase C2U37_09295 ENOG4108YZA Nitrogen regulatory protein pii C2U37_09300 ENOG4105BZU Histidine kinase C2U37_09310 ENOG4108NVR Methyl-accepting chemotaxis C2U37_09320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U37_09325 ENOG4105E0F Histidine kinase C2U37_09330 ENOG4105VEQ Cold shock protein C2U37_09335 ENOG4108J1Q C2U37_09355 ENOG4108UUM single-stranded DNA-binding protein C2U37_09360 ENOG41086KC Transcriptional regulator C2U37_09365 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2U37_09400 ENOG4105SYT Methylenetetrahydrofolate reductase C2U37_09410 ENOG4105DKK Benzoate C2U37_09415 ENOG4108JCI Transcriptional regulator C2U37_09445 ENOG41090HJ UPF0265 protein C2U37_09455 ENOG4105N42 UPF0307 protein C2U37_09460 ENOG4105CMS peptidase U62, modulator of DNA gyrase C2U37_09465 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2U37_09470 ENOG4105VFK BolA family C2U37_09480 ENOG4105E3I toluene tolerance C2U37_09485 ENOG4107PE3 Mammalian cell entry related domain protein C2U37_09490 ENOG4105CY3 ABC transporter, permease C2U37_09495 ENOG4105DHJ ABC, transporter C2U37_09500 ENOG4105C2X Arabinose 5-phosphate isomerase C2U37_09505 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase C2U37_09515 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA C2U37_09520 ENOG4108IUZ ABC transporter C2U37_09525 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U37_09530 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA C2U37_09535 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C2U37_09540 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C2U37_09545 ENOG41080Z8 PHOSPHOCARRIER protein C2U37_09550 ENOG4105CTS PTS system mannitol-specific C2U37_09565 ENOG41069H0 dihydroorotase EC 3.5.2.3 C2U37_09595 ENOG4105C0H protease C2U37_09600 ENOG4105C0H protease C2U37_09610 ENOG4105D6Z AFG1 family ATPase C2U37_09615 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C2U37_09620 ENOG4108UJD 30S ribosomal protein S9 C2U37_09625 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U37_09630 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U37_09635 ENOG4105EIX cytochrome c1 C2U37_09640 ENOG4107MKT Stringent starvation protein a C2U37_09645 ENOG4105KB2 stringent starvation protein b C2U37_09650 ENOG4105W4M Transport-associated protein C2U37_09655 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C2U37_09660 ENOG41082RQ UPF0102 protein C2U37_09665 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) C2U37_09670 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C2U37_09685 ENOG4105DD5 Flagellar motor switch protein C2U37_09690 ENOG4105CN7 Flagellar biosynthetic protein FliP C2U37_09695 ENOG4105VS8 Flagellar biosynthetic protein fliq C2U37_09700 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C2U37_09705 ENOG4105D00 flagellar biosynthetic protein flhB C2U37_09715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_09720 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C2U37_09725 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C2U37_09730 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U37_09740 ENOG4108JIR Flagellum-specific ATP synthase C2U37_09760 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA C2U37_09765 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2U37_09770 ENOG4108ZC9 flagellar basal-body rod protein flgc C2U37_09775 ENOG4105W00 Flagellar hook capping protein C2U37_09780 ENOG4105BZE flagellar hook protein, FlgE C2U37_09785 ENOG4108KPB Flagellar basal-body rod protein FlgF C2U37_09790 ENOG4105CGA flagellar basal-body rod protein FlgG C2U37_09795 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U37_09800 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U37_09810 ENOG4105E1Q flagellar hook-associated protein C2U37_09815 ENOG4105DTJ flagellar hook-associated protein C2U37_09825 ENOG4108C80 FliB family C2U37_09835 ENOG4105I03 Flagellin C2U37_09840 ENOG4105I03 Flagellin C2U37_09845 ENOG410804A Flagellar hook-associated 2 domain-containing protein C2U37_09850 ENOG4105MQ3 flagellar protein FliS C2U37_09875 ENOG4107RD7 Flagellar Motor Protein, MotA C2U37_09880 ENOG4105ER2 Ompa motb domain protein C2U37_09890 ENOG4105E9H Lytic Murein transglycosylase C2U37_09900 ENOG4108V6E Cell division protein mraZ C2U37_09905 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C2U37_09910 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C2U37_09915 ENOG4105CJN penicillin-binding protein C2U37_09920 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2U37_09925 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C2U37_09930 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C2U37_09935 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C2U37_09940 ENOG4105CNI cell division protein FtsW C2U37_09945 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C2U37_09950 ENOG4105DFU Cell wall formation (By similarity) C2U37_09955 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C2U37_09960 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2U37_09965 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C2U37_09970 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U37_09980 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C2U37_09990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2U37_09995 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) C2U37_10000 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) C2U37_10010 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) C2U37_10015 ENOG4105D7Q type ii secretion system C2U37_10020 ENOG4107QHF type ii secretion system protein e C2U37_10030 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C2U37_10045 ENOG41073TP transcriptional regulator C2U37_10050 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U37_10055 ENOG4107QSN dihydrolipoamide acetyltransferase C2U37_10060 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U37_10070 ENOG4108N3W hemolysin secretion protein C2U37_10075 ENOG4108N3W hemolysin secretion protein C2U37_10085 ENOG4107QIJ Aconitate hydratase 2 C2U37_10090 ENOG4105BZU Histidine kinase C2U37_10100 ENOG4105E82 cytochrome subunit of dehydrogenase C2U37_10110 ENOG4105CKI cobalamin synthesis protein C2U37_10115 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U37_10125 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2U37_10130 ENOG4107ZVW dihydroneopterin aldolase C2U37_10135 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2U37_10180 ENOG4107AQZ Membrane C2U37_10190 ENOG4108UW5 maltose o-acetyltransferase C2U37_10195 ENOG4105CG3 alpha amylase, catalytic region C2U37_10200 ENOG4105C5Y PTS System C2U37_10205 ENOG4105D4X repressor C2U37_10220 ENOG4105HDK L-asparaginase C2U37_10235 ENOG4108Z5K methylglyoxal synthase C2U37_10240 ENOG4108UQY Iron-storage protein C2U37_10255 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) C2U37_10260 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) C2U37_10270 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) C2U37_10300 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2U37_10305 ENOG4105C26 Dehydrogenase C2U37_10310 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component C2U37_10315 ENOG4105D81 ABC transporter, permease C2U37_10320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U37_10325 ENOG4107TYH extracellular solute-binding protein family 1 C2U37_10330 ENOG4108M0I Transcriptional regulator C2U37_10335 ENOG4105DFD Na H antiporter C2U37_10375 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C2U37_10380 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2U37_10385 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C2U37_10390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U37_10400 ENOG4107VXZ Hydrolase C2U37_10405 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2U37_10410 ENOG4105F1S paraquat-inducible protein a C2U37_10415 ENOG4105DY2 Paraquat-inducible protein b C2U37_10420 ENOG4108Q2G (LipO)protein C2U37_10425 ENOG4105UYK outer membrane protein a C2U37_10445 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) C2U37_10450 ENOG4105CEN a g-specific adenine glycosylase C2U37_10465 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C2U37_10470 ENOG4105CJ3 phosphate transporter C2U37_10475 ENOG4107IX6 phosphate transport regulator C2U37_10480 ENOG4105I7R Adenylate cyclase C2U37_10485 ENOG4108XTF Outer Membrane Lipoprotein C2U37_10490 ENOG4108R6G acetyltransferase C2U37_10505 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C2U37_10510 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C2U37_10515 ENOG4105VEJ Heat shock protein C2U37_10525 ENOG4105GVR general secretion pathway protein D C2U37_10530 ENOG4107QHF type ii secretion system protein e C2U37_10535 ENOG4105D7Q type ii secretion system C2U37_10540 ENOG4108VAU general secretion pathway protein G C2U37_10585 ENOG4108UDW Transcriptional regulator, luxr family C2U37_10590 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2U37_10595 ENOG4105EQ2 LysR family Transcriptional regulator C2U37_10605 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 C2U37_10610 ENOG4107RK2 ADP-ribose diphosphatase NudE C2U37_10615 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C2U37_10620 ENOG4105C44 Serine transporter C2U37_10625 ENOG4108Z7R Chaperone CsaA C2U37_10635 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) C2U37_10640 ENOG4105C28 cystathionine C2U37_10645 ENOG4105CFH Aspartokinase C2U37_10650 ENOG41067MG lrgb family C2U37_10660 ENOG4105CMU LysR family (Transcriptional regulator C2U37_10695 ENOG4108Z66 YbaK ebsC protein C2U37_10705 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C2U37_10715 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C2U37_10720 ENOG4105CAS nag kinase C2U37_10730 ENOG4105CDH Citrulline--aspartate ligase C2U37_10735 ENOG4105CH7 arginosuccinase C2U37_10740 ENOG4107NQ8 LysR family Transcriptional regulator C2U37_10750 ENOG41090U3 tautomerase C2U37_10780 ENOG4108UW5 maltose o-acetyltransferase C2U37_10785 ENOG4107PU6 Membrane C2U37_10790 ENOG4105CT1 (ABC) transporter C2U37_10795 ENOG4105CDA abc transporter atp-binding protein C2U37_10800 ENOG4105E5Q amino acid AbC transporter C2U37_10805 ENOG4105E5Q amino acid AbC transporter C2U37_10810 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C2U37_10825 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2U37_10830 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C2U37_10840 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_10845 ENOG4105EYW Ion transport protein C2U37_10850 ENOG4106MWK domain protein C2U37_10855 ENOG4105E09 nadh pyrophosphatase C2U37_10860 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C2U37_10865 ENOG4105DKQ ROK family C2U37_10870 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C2U37_10875 ENOG4105BZA Phosphoglycerate kinase C2U37_10880 ENOG4105D2N Aldolase C2U37_10885 ENOG4105CJP fad dependent oxidoreductase C2U37_10900 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C2U37_10905 ENOG4105VF7 tolerance protein C2U37_10920 ENOG4105DUM transcriptional regulator, lysR family C2U37_10930 ENOG4105Y75 tpr repeat protein C2U37_10940 ENOG4108IYU L-aspartate oxidase C2U37_10945 ENOG4105EMN RNA polymerase sigma factor C2U37_10950 ENOG41069PW sigma-e factor negative regulatory protein C2U37_10965 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C2U37_10970 ENOG4105C3F Signal peptidase i C2U37_10975 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C2U37_10985 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C2U37_10990 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C2U37_10995 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase C2U37_11000 ENOG4108W15 Protein of unknown function (DUF1456) C2U37_11005 ENOG4105BZU Histidine kinase C2U37_11010 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2U37_11015 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U37_11020 ENOG4105DXN mazG family C2U37_11025 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C2U37_11030 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C2U37_11035 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C2U37_11040 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C2U37_11045 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C2U37_11050 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) C2U37_11055 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C2U37_11060 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C2U37_11065 ENOG4108UM1 dedA family C2U37_11070 ENOG4108K5P (LipO)protein C2U37_11080 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U37_11085 ENOG4105VCC 30S ribosomal protein S21 C2U37_11090 ENOG4105KTH gatB Yqey C2U37_11095 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C2U37_11100 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U37_11120 ENOG4105F2I Transposase C2U37_11130 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C2U37_11140 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C2U37_11145 ENOG4105C11 sulfate adenylyltransferase), subunit 2 C2U37_11150 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U37_11155 ENOG4107QX8 SPFH domain, Band 7 family protein C2U37_11160 ENOG4105G5H Membrane C2U37_11170 ENOG4105D9R oxidoreductase C2U37_11180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C2U37_11185 ENOG4105CSA Coproporphyrinogen iii oxidase C2U37_11205 ENOG4105DC1 bifunctional purine biosynthesis protein purh C2U37_11210 ENOG4105C12 Phosphoribosylglycinamide synthetase C2U37_11275 ENOG4105C19 ABC transporter C2U37_11290 ENOG4108UUE Transcriptional regulator C2U37_11305 ENOG4105F0N pyrophosphate phospho-hydrolase C2U37_11310 ENOG4105DFU Cell wall formation (By similarity) C2U37_11315 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C2U37_11320 ENOG410630P Transcriptional regulator C2U37_11325 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2U37_11330 ENOG4105DA5 (ABC) transporter C2U37_11335 ENOG4105E3A (ABC) transporter C2U37_11345 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C2U37_11350 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C2U37_11355 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2U37_11360 ENOG4105DJ0 Poly(A) Polymerase C2U37_11365 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C2U37_11370 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C2U37_11375 ENOG4105PW4 Sugar fermentation stimulation protein homolog C2U37_11385 ENOG4105CQ7 ATP-dependent helicase C2U37_11390 ENOG4105BZ4 penicillin-binding protein C2U37_11395 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C2U37_11400 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) C2U37_11405 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) C2U37_11410 ENOG4105EGI Transcriptional regulator C2U37_11420 ENOG41076MN Phosphoesterase, PA-phosphatase related C2U37_11435 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2U37_11440 ENOG4105CMQ Chloride channel C2U37_11450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2U37_11480 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) C2U37_11485 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U37_11495 ENOG4107V40 secretion protein, HlyD family C2U37_11525 ENOG4105I93 response regulator C2U37_11530 ENOG4105DUX Transporter C2U37_11535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2U37_11540 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein C2U37_11545 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C2U37_11550 ENOG4105K9H YciI-like protein C2U37_11555 ENOG4107835 probably involved in intracellular septation (By similarity) C2U37_11560 ENOG4105DY8 decarboxylase C2U37_11565 ENOG4108UT2 hemolysin iii C2U37_11570 ENOG4105D0C transport protein C2U37_11580 ENOG4105EV4 Multidrug resistance protein mdtH C2U37_11590 ENOG4105D4Y metalloprotease C2U37_11600 ENOG4105D9U N-acetyltransferase C2U37_11610 ENOG4105XEP YhcH YjgK YiaL family protein C2U37_11620 ENOG4105CUY Mechanosensitive ion channel C2U37_11625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U37_11630 ENOG4105CK7 Sodium proline symporter C2U37_11680 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C2U37_11685 ENOG4105D6S protein involved in catabolism of external DNA C2U37_11695 ENOG4105C5H ABC transporter C2U37_11700 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U37_11710 ENOG4107R88 Chemotaxis protein (CheV) C2U37_11715 ENOG4108UJV acyl-CoA thioesterase i C2U37_11720 ENOG4108I0Y (ABC) transporter C2U37_11725 ENOG4105CV6 ABC transporter, permease C2U37_11730 ENOG4105ECP epimerase C2U37_11735 ENOG4107XTP (EAL) domain protein C2U37_11740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U37_11745 ENOG4105IIU Aminopeptidase C2U37_11750 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C2U37_11755 ENOG41090ED Protein with unknown function (DUF469) C2U37_11760 ENOG4105CSV Glutaminase C2U37_11765 ENOG4107RM6 sulfurtransferase C2U37_11770 ENOG4105E3R (LipO)protein C2U37_11775 ENOG4108W78 Pfam:DUF1017 C2U37_11780 ENOG4108MDC (LipO)protein C2U37_11810 ENOG4105SUV lipoprotein YgdR C2U37_11815 ENOG4105BZ1 (ABC) transporter C2U37_11840 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) C2U37_11845 ENOG4105BZU Histidine kinase C2U37_11865 ENOG4105VYA Uncharacterized conserved protein (DUF2132) C2U37_11870 ENOG4105DJ4 phosphatidylserine decarboxylase C2U37_11875 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C2U37_11880 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C2U37_11915 ENOG4105VEQ Cold shock protein C2U37_11925 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_11930 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U37_11935 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U37_11985 ENOG4109015 Biopolymer transport protein exbD tolR C2U37_12010 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C2U37_12015 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C2U37_12030 ENOG4108JQ7 (ABC) transporter C2U37_12040 ENOG4105CIN aminoacyl-histidine dipeptidase C2U37_12100 ENOG410685N tail fiber protein C2U37_12190 ENOG4105ED4 portal protein C2U37_12295 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2U37_12305 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_12310 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) C2U37_12315 ENOG4105V1F Fermentation respiration switch protein C2U37_12320 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) C2U37_12330 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C2U37_12360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U37_12375 ENOG4105DG7 nitrate ABC transporter C2U37_12380 ENOG4105D7T ABC transporter C2U37_12385 ENOG4107QZF nitrite reductase NADPH large subunit C2U37_12390 ENOG4107QZF nitrite reductase NADPH large subunit C2U37_12395 ENOG4105DD7 kinase (PfkB family C2U37_12400 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) C2U37_12420 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U37_12430 ENOG4105DWK Membrane C2U37_12435 ENOG4107XM3 UPF0442 protein C2U37_12445 ENOG4108IJ7 Glycine betaine C2U37_12450 ENOG4108HQS Glycine betaine C2U37_12455 ENOG4105GIJ Glycine betaine C2U37_12460 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C2U37_12465 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C2U37_12470 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C2U37_12475 ENOG4107TIF Phenazine biosynthesis protein, PhzF family C2U37_12480 ENOG4105CRK lysyL-tRNA synthetase C2U37_12490 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_12495 ENOG4105D6U Sodium Glutamate Symporter C2U37_12500 ENOG4105HDK L-asparaginase C2U37_12505 ENOG4105VUT cytoplasmic protein C2U37_12525 ENOG4105D07 Signal peptide peptidase, SppA C2U37_12530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U37_12535 ENOG41069NU Nitroreductase C2U37_12545 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_12555 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C2U37_12560 ENOG4105CIS alcohol dehydrogenase C2U37_12565 ENOG4105HEI LysR family (Transcriptional regulator C2U37_12570 ENOG4105CI1 PTS System C2U37_12575 ENOG4108IA2 Sodium pantothenate symporter C2U37_12580 ENOG4105RG0 Membrane C2U37_12585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2U37_12590 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C2U37_12595 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C2U37_12600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U37_12605 ENOG4105BZU Histidine kinase C2U37_12615 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) C2U37_12630 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2U37_12640 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C2U37_12645 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2U37_12660 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C2U37_12665 ENOG4107YIM Involved in the transcription termination process (By similarity) C2U37_12670 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C2U37_12675 ENOG4108ZAI phosphatidylglycerophosphatase a C2U37_12680 ENOG4108JQ6 ABC transporter C2U37_12690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U37_12695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U37_12700 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C2U37_12705 ENOG4105CTB Polyprenyl synthetase C2U37_12710 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U37_12715 ENOG4105E14 MotA TolQ exbB proton channel C2U37_12720 ENOG4107XSU flagellar motor protein motb C2U37_12725 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C2U37_12735 ENOG4105HBR Rna-binding protein C2U37_12740 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) C2U37_12745 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U37_12750 ENOG4105EEI dihydropteroate synthase C2U37_12755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C2U37_12760 ENOG4105CP7 Triose-phosphate isomerase C2U37_12780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C2U37_12785 ENOG4105CHV Transcription elongation factor NusA C2U37_12790 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C2U37_12795 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C2U37_12800 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C2U37_12805 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C2U37_12810 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C2U37_12815 ENOG4105E5W Transporter C2U37_12820 ENOG41090EX DsrE family C2U37_12825 ENOG4105WAY exported protein C2U37_12835 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C2U37_12840 ENOG4105CFP Peptidase U32 C2U37_12845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U37_12870 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) C2U37_12875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_12880 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C2U37_12890 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C2U37_12895 ENOG4107SWG transcriptional regulator MERR family C2U37_12910 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U37_12920 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C2U37_12925 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C2U37_12930 ENOG4108Z43 UPF0250 protein C2U37_12935 ENOG4105DZ1 carboxypeptidase C2U37_12940 ENOG4105K6T rare lipoprotein A C2U37_12945 ENOG4105CVE Lytic murein transglycosylase C2U37_12950 ENOG4105CNI cell division protein FtsW C2U37_12955 ENOG4105CJN penicillin-binding protein C2U37_12960 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C2U37_12965 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) C2U37_12970 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C2U37_12985 ENOG4105C8T Leucyl-tRNA synthetase C2U37_12990 ENOG4107PAI alpha helical protein C2U37_12995 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C2U37_13000 ENOG4108JU5 Magnesium and cobalt efflux protein C2U37_13005 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C2U37_13010 ENOG4105C9A Phoh family C2U37_13015 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2U37_13020 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C2U37_13025 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) C2U37_13030 ENOG4105VEQ Cold shock protein C2U37_13045 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 C2U37_13050 ENOG4105BZU Histidine kinase C2U37_13060 ENOG4108KHX Diguanylate cyclase C2U37_13070 ENOG4105C5I Dehydrogenase C2U37_13085 ENOG4105D01 (LipO)protein C2U37_13090 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U37_13095 ENOG4108UMI ABC transporter, permease C2U37_13100 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C2U37_13110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U37_13115 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C2U37_13120 ENOG4105DHQ Histidine kinase C2U37_13125 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U37_13135 ENOG4108IXY short-chain dehydrogenase reductase C2U37_13155 ENOG4106371 Methyltransferase C2U37_13160 ENOG4105T0Z Conserved Protein C2U37_13175 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) C2U37_13180 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) C2U37_13185 ENOG4105E33 succinate dehydrogenase C2U37_13195 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_13200 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2U37_13205 ENOG4105EGS Mechanosensitive ion channel C2U37_13215 ENOG4105DR5 peptidase C2U37_13230 ENOG4105EJC lysr family transcriptional regulator C2U37_13245 ENOG4105C5Q Transcriptional regulator C2U37_13250 ENOG4108JQC penicillin-binding protein 1A C2U37_13275 ENOG4105E4G Type IV pilus C2U37_13280 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C2U37_13285 ENOG4105D49 3-dehydroquinate synthase C2U37_13295 ENOG4105DFE Dna adenine methylase C2U37_13300 ENOG4105DJV ribulose-phosphate 3-epimerase C2U37_13305 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U37_13310 ENOG4105C31 Tryptophanyl-tRNA synthetase C2U37_13325 ENOG4105C8Y Acetylornithine aminotransferase C2U37_13330 ENOG4105F4X arginine C2U37_13335 ENOG4105C26 Dehydrogenase C2U37_13350 ENOG4107VXZ Hydrolase C2U37_13370 ENOG41060QA UPF0267 protein C2U37_13375 ENOG4107QWE )-transporter C2U37_13440 ENOG4105CB5 ATP-dependent DNA helicase recG C2U37_13445 ENOG4105ESI atpase involved in dna repair C2U37_13450 ENOG4105DZR Type I site-specific deoxyribonuclease C2U37_13470 ENOG4105EQR Transposase IS116 IS110 IS902 C2U37_13515 ENOG4108KU3 Integrase C2U37_13550 ENOG4108XFH Transcriptional regulator C2U37_13555 ENOG4105F6U Short-chain dehydrogenase reductase Sdr C2U37_13570 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U37_13595 ENOG4105CHU acetyl-coa acetyltransferase C2U37_13660 ENOG4105CYM Glutathione S-transferase C2U37_13665 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U37_13675 ENOG4105F04 LysR family Transcriptional regulator C2U37_13685 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U37_13715 ENOG41067TZ transcriptional regulator, MarR family C2U37_13720 ENOG4105DUM transcriptional regulator, lysR family C2U37_13795 ENOG4105E4C Lytic transglycosylase catalytic C2U37_13820 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U37_13895 ENOG4105F5W AtP-binding protein C2U37_13900 ENOG4105D70 Integrase catalytic subunit C2U37_14000 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off C2U37_14015 ENOG4105DFP Integrase C2U37_14020 ENOG4105C3G gtp-binding protein C2U37_14025 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C2U37_14030 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2U37_14040 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C2U37_14045 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C2U37_14050 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C2U37_14055 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C2U37_14060 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C2U37_14070 ENOG41063JG Transcriptional regulator C2U37_14075 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2U37_14080 ENOG4105CK2 sodium dicarboxylate symporter C2U37_14085 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) C2U37_14090 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C2U37_14105 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2U37_14110 ENOG4105BZG amino acid carrier protein C2U37_14115 ENOG41066YJ Beta-lactamase C2U37_14130 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C2U37_14135 ENOG4108UJU UPF0301 protein C2U37_14140 ENOG4105D7Z glutathione synthase C2U37_14145 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C2U37_14155 ENOG4105GPY SprT protein C2U37_14160 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C2U37_14165 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2U37_14175 ENOG4105KME endoribonuclease L-psp C2U37_14190 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C2U37_14195 ENOG4105DR5 peptidase C2U37_14200 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2U37_14205 ENOG4107WCA isomerase C2U37_14215 ENOG4108V1U phospholipid-binding protein C2U37_14220 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C2U37_14235 ENOG4105C87 Aminotransferase class I and II C2U37_14245 ENOG4105C5Q Transcriptional regulator C2U37_14250 ENOG4105UBK short-chain dehydrogenase reductase C2U37_14255 ENOG4105ERU peptidase C2U37_14260 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) C2U37_14265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U37_14275 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U37_14280 ENOG4105E2D ec 3.2.1.52 C2U37_14285 ENOG4105RD7 BadF BadG BcrA BcrD C2U37_14295 ENOG4108JQ7 (ABC) transporter C2U37_14305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U37_14320 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C2U37_14325 ENOG4105EQR Transposase IS116 IS110 IS902 C2U37_14365 ENOG4108YX2 DNA-binding protein C2U37_14390 ENOG4105DFG type I secretion outer membrane protein C2U37_14395 ENOG4108IJF Heavy metal efflux pump, CzcA C2U37_14400 ENOG4105EP1 Efflux transporter rnd family, mfp subunit C2U37_14410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U37_14415 ENOG4105GR3 Histidine kinase C2U37_14425 ENOG4105W1Y Transcriptional regulator C2U37_14465 ENOG4105E3B Multicopper oxidase C2U37_14475 ENOG4105F2I Transposase C2U37_14535 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U37_14540 ENOG41085FC arsR family transcriptional regulator C2U37_14545 ENOG4105D6J arsenicaL-resistance protein C2U37_14550 ENOG4105K89 arsenate reductase C2U37_14560 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C2U37_14565 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C2U37_14570 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U37_14580 ENOG4108JIR Flagellum-specific ATP synthase C2U37_14600 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U37_14605 ENOG4105DD5 Flagellar motor switch protein C2U37_14610 ENOG4105VTB flagellar biosynthesis protein fliO C2U37_14615 ENOG4105CN7 Flagellar biosynthetic protein FliP C2U37_14620 ENOG4105VS8 Flagellar biosynthetic protein fliq C2U37_14625 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C2U37_14630 ENOG4105D00 flagellar biosynthetic protein flhB C2U37_14635 ENOG4105D7B Flagellar biosynthesis protein flha C2U37_14640 ENOG4105FZW flagellar biosynthesis regulator FlhF C2U37_14650 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U37_14655 ENOG4108VYJ response regulator receiver protein C2U37_14660 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) C2U37_14665 ENOG4105CBS Chea signal transduction histidine kinase C2U37_14670 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C2U37_14675 ENOG4105E14 MotA TolQ exbB proton channel C2U37_14680 ENOG4108SEK ompa motb domain protein C2U37_14685 ENOG4107QJE Chromosome Partitioning Protein C2U37_14695 ENOG4108V3W Chemotaxis protein, CheW C2U37_14710 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) C2U37_14715 ENOG41060IM Heme exporter protein C2U37_14720 ENOG4105X3C heme exporter protein C2U37_14725 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) C2U37_14730 ENOG4105DA4 cytochrome c-type biogenesis protein C2U37_14735 ENOG4107QX9 Thiol disulfide interChange protein C2U37_14740 ENOG4105KWW Biogenesis protein C2U37_14750 ENOG410903C (LipO)protein C2U37_14755 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U37_14760 ENOG4105M2J Glutaredoxin C2U37_14780 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C2U37_14785 ENOG4107R11 Transcriptional regulator C2U37_14810 ENOG4108YYD acetyltransferase C2U37_14825 ENOG4108UHU Aldolase C2U37_14855 ENOG4105F5W AtP-binding protein C2U37_14860 ENOG4105D70 Integrase catalytic subunit C2U37_14890 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U37_14925 ENOG4108J1Q C2U37_14980 ENOG4105F2I Transposase C2U37_14990 ENOG4108J1Q C2U37_15005 ENOG4105F2I Transposase C2U37_15015 ENOG4105DFP Integrase C2U37_15020 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_15065 ENOG4105CNU cell division protein FtsK C2U37_15100 ENOG41076J9 exonuclease VIII C2U37_15135 ENOG4105RDA repressor C2U37_15145 ENOG4108ZUE Phage regulatory protein rha C2U37_15185 ENOG4105NY2 NinB protein C2U37_15190 ENOG4108R1E Serine threonine protein phosphatase 1 C2U37_15355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C2U37_15360 ENOG4108Z1B Cyclase dehydrase C2U37_15365 ENOG4105VDB UPF0125 protein C2U37_15370 ENOG4105K4T epimerase C2U37_15375 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U37_15380 ENOG4105C0A alcohol dehydrogenase C2U37_15445 ENOG4105ZIA Phage protein gp16 C2U37_15490 ENOG4108Z6H mu-like prophage Flumu protein gp27 C2U37_15495 ENOG4105CF2 Mu-like prophage FluMu protein GP28 C2U37_15500 ENOG4105QIB mu-like prophage Flumu protein gp29 C2U37_15505 ENOG4108QUU Morphogenesis Protein C2U37_15515 ENOG4108TVE i protein C2U37_15520 ENOG4105EFV Major head subunit C2U37_15605 ENOG4108I5U Uridine phosphorylase C2U37_15610 ENOG4105D3G Pseudouridine synthase C2U37_15615 ENOG4105DU0 nucleoside hydrolase C2U37_15630 ENOG4105RX8 Protein of unknown function (DUF1523) C2U37_15635 ENOG4108NVR Methyl-accepting chemotaxis C2U37_15640 ENOG410829K Lysine exporter protein (Lyse ygga) C2U37_15650 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C2U37_15665 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C2U37_15670 ENOG4105KUZ arsenate reductase C2U37_15695 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2U37_15700 ENOG4105C5S asparaginyl-tRNA synthetase C2U37_15720 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C2U37_15725 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C2U37_15730 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2U37_15735 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C2U37_15740 ENOG4105D0M Protease HtpX homolog C2U37_15745 ENOG4105QVC MOSC domain-containing protein C2U37_15745 ENOG4105QVC MOSC domain-containing protein C2U37_15755 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) C2U37_15760 ENOG4105Z2P Protein of unknown function (DUF465) C2U37_15770 ENOG4105UQX Mate efflux family protein C2U37_15790 ENOG4105C6T cysteine synthase C2U37_15805 ENOG4107Z3H Transcriptional regulator, TetR family C2U37_15810 ENOG4107RGH Aldehyde dehydrogenase C2U37_15820 ENOG4108QBX (LipO)protein C2U37_15825 ENOG4105C5Q Transcriptional regulator C2U37_15845 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C2U37_15850 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) C2U37_15855 ENOG41081XQ Conserved Protein C2U37_15865 ENOG4105C9M aspartyl-trna synthetase C2U37_15870 ENOG4105CDY transcriptional regulatory protein C2U37_15875 ENOG4105DIJ Phosphoethanolamine transferase C2U37_15880 ENOG4105E2R ROK family C2U37_15885 ENOG4105CE4 GlcNAc 6-P deacetylase C2U37_15890 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C2U37_15895 ENOG4105CI1 PTS System C2U37_15900 ENOG4105E2D ec 3.2.1.52 C2U37_15905 ENOG4105CX6 glutaminyL-tRNA synthetase C2U37_15910 ENOG41090R7 Ferric uptake C2U37_15920 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) C2U37_15925 ENOG4105NNH LexA regulated protein C2U37_15935 ENOG4105EV9 Alpha Beta Hydrolase C2U37_15940 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) C2U37_15945 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 C2U37_15955 ENOG41090MY MarR family Transcriptional regulator C2U37_15960 ENOG4105CVE Lytic murein transglycosylase C2U37_15965 ENOG4108T9J Cdp-alcohol phosphatidyltransferase C2U37_15970 ENOG4108VGW abc transporter atp-binding protein C2U37_15980 ENOG4105VNH ABC transporter solute-binding protein C2U37_15990 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U37_16000 ENOG4105KQ5 peptidylprolyl cis-trans isomerase C2U37_16010 ENOG4105CFU surface antigen C2U37_16015 ENOG4105MA0 exported protein C2U37_16035 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA C2U37_16040 ENOG4105BZU Histidine kinase C2U37_16045 ENOG4107SC1 transglycosylase C2U37_16050 ENOG41060NJ transcriptional regulator C2U37_16060 ENOG4105NAU thioesterase Superfamily protein C2U37_16070 ENOG4107NA1 Endonuclease Exonuclease phosphatase C2U37_16075 ENOG4105E9H Lytic Murein transglycosylase C2U37_16080 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C2U37_16085 ENOG4105D1A Methyltransferase C2U37_16090 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U37_16095 ENOG4107RZZ dna polymerase iii epsilon subunit C2U37_16110 ENOG4107QPN acyl-Coa dehydrogenase C2U37_16115 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C2U37_16120 ENOG4105E7A Glutamine amidotransferase C2U37_16130 ENOG4105CHW UPF0052 protein C2U37_16140 ENOG4105BZU Histidine kinase C2U37_16165 ENOG4105WH1 Two component transcriptional regulator luxr family C2U37_16170 ENOG4105BZU Histidine kinase C2U37_16175 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U37_16180 ENOG4108BGM Quinol dehydrogenase periplasmic component C2U37_16190 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C2U37_16195 ENOG4108BGM Quinol dehydrogenase periplasmic component C2U37_16200 ENOG4105GXZ Ferredoxin-type protein NapH C2U37_16210 ENOG4105CUW cytochrome C-TYPE protein C2U37_16215 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U37_16220 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U37_16225 ENOG4105M00 molybdopterin converting factor, subunit 1 C2U37_16230 ENOG4108ZAF Molybdopterin C2U37_16235 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2U37_16240 ENOG4105E0C molybdate abc transporter C2U37_16245 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C2U37_16250 ENOG410832A alpha/beta hydrolase fold C2U37_16265 ENOG4105D06 uba thif-type nad fad binding protein C2U37_16270 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2U37_16275 ENOG4105EUJ GTP cyclohydrolase i C2U37_16280 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_16285 ENOG4105CKU formyltetrahydrofolate synthetase C2U37_16295 ENOG4105CC0 LysR family Transcriptional regulator C2U37_16300 ENOG4108YYC ycei family C2U37_16310 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C2U37_16325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2U37_16335 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) C2U37_16350 ENOG4105BZU Histidine kinase C2U37_16365 ENOG4105F2I Transposase C2U37_16390 ENOG4105D82 Glutamate dehydrogenase C2U37_16395 ENOG4105FE9 pseudouridine synthase C2U37_16400 ENOG4105DJ2 Major Facilitator Superfamily C2U37_16410 ENOG4105C5Q Transcriptional regulator C2U37_16420 ENOG4106428 Protein of unknown function (DUF2496) C2U37_16430 ENOG4108Q2J Inner membrane protein YebE C2U37_16440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U37_16445 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U37_16450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U37_16460 ENOG4105F27 Major Facilitator C2U37_16465 ENOG4105CV8 reductase C2U37_16480 ENOG4105F2I Transposase C2U37_16495 ENOG4105HEI LysR family (Transcriptional regulator C2U37_16500 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C2U37_16505 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C2U37_16510 ENOG4105CXY transporter C2U37_16515 ENOG4105E98 transcriptional regulator DeoR family C2U37_16520 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C2U37_16525 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase C2U37_16530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U37_16545 ENOG4108WFC UPF0438 protein yifE C2U37_16550 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) C2U37_16570 ENOG4105CUG Oligopeptidase b C2U37_16575 ENOG4105D05 Receptor C2U37_16580 ENOG4105E68 Sulfatase C2U37_16585 ENOG4105PAN UPF0352 protein C2U37_16590 ENOG4106V8H Nucleoid-associated protein C2U37_16595 ENOG4107FKK extracellular solute-binding protein family 1 C2U37_16600 ENOG4105D56 permease protein C2U37_16605 ENOG4105EG2 ABC transporter, permease C2U37_16610 ENOG4108IJ9 (ABC) transporter C2U37_16615 ENOG4105CSR polyphosphate kinase 2 C2U37_16620 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) C2U37_16635 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C2U37_16640 ENOG4105ERG peptidase m48, ste24p C2U37_16650 ENOG4105K89 arsenate reductase C2U37_16665 ENOG4108ZYK Acyl carrier protein phosphodiesterase C2U37_16675 ENOG4106PMH Extracellular solute-binding protein family 3 C2U37_16680 ENOG4105DYB Isoaspartyl dipeptidase C2U37_16685 ENOG4105DWU Membrane C2U37_16690 ENOG4108JEH abc transporter atp-binding protein C2U37_16695 ENOG4106PMH Extracellular solute-binding protein family 3 C2U37_16700 ENOG4105DSP amino acid AbC transporter C2U37_16705 ENOG4106YG3 ABC transporter C2U37_16715 ENOG4105F1A Pyruvate formate-lyase C2U37_16720 ENOG4105BZU Histidine kinase C2U37_16725 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C2U37_16740 ENOG4105J12 Multidrug resistance protein mdtN C2U37_16750 ENOG4105IPI Membrane C2U37_16755 ENOG4105DN3 alpha-2-macroglobulin domain protein C2U37_16760 ENOG4108JQB penicillin-binding protein 1C C2U37_16770 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C2U37_16780 ENOG4105EN6 Membrane C2U37_16790 ENOG4105I03 Flagellin C2U37_16795 ENOG41063QE flagellar protein FlaG C2U37_16805 ENOG4105MQ3 flagellar protein FliS C2U37_16825 ENOG4105D2T synthase C2U37_16840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2U37_16845 ENOG4107TY6 Acylneuraminate cytidylyltransferase C2U37_16855 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C2U37_16860 ENOG4105C5E polysaccharide biosynthesis protein C2U37_16865 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2U37_16875 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C2U37_16895 ENOG4105VNT transposase (IS4 family) protein C2U37_16900 ENOG4108UYE Lactoylglutathione lyase C2U37_16905 ENOG4105CSM endonuclease III C2U37_16910 ENOG4105DZB Electron transport complex C2U37_16915 ENOG4108UQQ Electron transport complex C2U37_16920 ENOG4105D6A Electron transport complex C2U37_16930 ENOG4108R3D Electron transport complex C2U37_16935 ENOG4105DGN Electron transport complex C2U37_16940 ENOG4105D7V transposase C2U37_16950 ENOG4108PCN EamA-like transporter family C2U37_16960 ENOG4107SDU Methyl-accepting chemotaxis C2U37_16970 ENOG4105RKW reductase (By C2U37_16980 ENOG4105CHM Aminotransferase C2U37_16990 ENOG41090BQ Glutaredoxin C2U37_16995 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase C2U37_17000 ENOG4105CFI type iii restriction protein res subunit C2U37_17005 ENOG4105EFX secretion protein, HlyD family C2U37_17010 ENOG4105KK7 inner membrane protein YiaW C2U37_17015 ENOG4105EGS Mechanosensitive ion channel C2U37_17025 ENOG4108NEV two component transcriptional regulator, LytTR family C2U37_17030 ENOG4108HRK Histidine kinase C2U37_17035 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U37_17040 ENOG4108EKI Dehydrogenase C2U37_17045 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C2U37_17050 ENOG4107QSI ABC, transporter C2U37_17055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U37_17060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U37_17065 ENOG4105C3U ABC transporter C2U37_17070 ENOG4108JQ7 (ABC) transporter C2U37_17075 ENOG4105DU1 integral membrane protein, terc C2U37_17080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U37_17090 ENOG4107QJT sodium dicarboxylate symporter C2U37_17110 ENOG4105CD3 dihydroorotase C2U37_17120 ENOG4108NVR Methyl-accepting chemotaxis C2U37_17125 ENOG4105K59 histidine triad (HIT) protein C2U37_17160 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U37_17165 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U37_17170 ENOG4107SDU Methyl-accepting chemotaxis C2U37_17180 ENOG4105CKW Inner membrane protein yedI C2U37_17185 ENOG4105DPN Oligoendopeptidase f C2U37_17190 ENOG4105DPN Oligoendopeptidase f C2U37_17200 ENOG4105CEP NADH dehydrogenase C2U37_17205 ENOG4105K8R UPF0145 protein C2U37_17210 ENOG4107T7U Sulfatase C2U37_17220 ENOG4105CFH Aspartokinase C2U37_17225 ENOG4107QZM n-acetylglutamate synthase C2U37_17230 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U37_17255 ENOG4105CR8 Transcriptional regulator C2U37_17260 ENOG4105DAA L-lactate C2U37_17265 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U37_17270 ENOG4107QR9 Iron-sulfur cluster binding protein C2U37_17275 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C2U37_17295 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C2U37_17315 ENOG4105C2C drug resistance transporter, Bcr CflA C2U37_17410 ENOG4105CHH sulfate transporter C2U37_17430 ENOG4105D70 Integrase catalytic subunit C2U37_17435 ENOG4105F5W AtP-binding protein C2U37_17480 ENOG4105BZU Histidine kinase C2U37_17485 ENOG4105BZU Histidine kinase C2U37_17500 ENOG4105DZR Type I site-specific deoxyribonuclease C2U37_17545 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U37_17550 ENOG4105F2I Transposase C2U37_17555 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C2U37_17565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C2U37_17570 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C2U37_17575 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2U37_17580 ENOG4105WJG Glutathione C2U37_17585 ENOG4107RE1 Inosine-guanosine kinase C2U37_17590 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_17610 ENOG4105BZU Histidine kinase C2U37_17615 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2U37_17625 ENOG4105F3T (LipO)protein C2U37_17635 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C2U37_17640 ENOG4105WQI isochorismatase C2U37_17645 ENOG4105CEY Amp-dependent synthetase and ligase C2U37_17650 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C2U37_17660 ENOG4105CEY Amp-dependent synthetase and ligase C2U37_17670 ENOG4105J76 Periplasmic binding protein C2U37_17675 ENOG4108TSE Transferase C2U37_17680 ENOG4105E0A ABC, transporter C2U37_17685 ENOG4105TVJ transport system, permease C2U37_17690 ENOG4105DQ5 transport system permease protein C2U37_17695 ENOG4105D05 Receptor C2U37_17710 ENOG4105QZU Inner membrane protein YfeZ C2U37_17715 ENOG4107QUT magnesium and cobalt transport protein CorA C2U37_17720 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C2U37_17725 ENOG4105BZJ Electron transfer flavoprotein C2U37_17730 ENOG4105C10 Electron transfer flavoprotein C2U37_17735 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C2U37_17740 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C2U37_17745 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U37_17750 ENOG4105EE5 Membrane protein terC C2U37_17760 ENOG4105MH2 YfcL protein C2U37_17765 ENOG4108IQE Amp-dependent synthetase and ligase C2U37_17770 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) C2U37_17775 ENOG41067MG lrgb family C2U37_17780 ENOG4105VAW lrga family C2U37_17785 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 C2U37_17795 ENOG4105CJB Exodeoxyribonuclease I C2U37_17800 ENOG4105DFP Integrase C2U37_17805 ENOG4108UUM single-stranded DNA-binding protein C2U37_17865 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2U37_17905 ENOG4106050 phage regulatory protein, rha family C2U37_17960 ENOG4105CAR Terminase, large subunit C2U37_18080 ENOG4108J1Q C2U37_18085 ENOG4105F2I Transposase C2U37_18120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U37_18180 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2U37_18260 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2U37_18265 ENOG4105FF5 Membrane C2U37_18285 ENOG4105CHM Aminotransferase C2U37_18290 ENOG4105ETT transcriptional Regulator, LysR family C2U37_18295 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C2U37_18305 ENOG4105EF1 ribulokinase C2U37_18310 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator C2U37_18320 ENOG4105CNN ABC, transporter C2U37_18335 ENOG4105NRA 50s ribosomal protein l31 type b C2U37_18350 ENOG4108VKG metal-dependent hydrolase C2U37_18365 ENOG4105CEE C4-dicarboxylate transporter C2U37_18375 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C2U37_18380 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2U37_18395 ENOG4105BZN citrate synthase C2U37_18400 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit C2U37_18405 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein C2U37_18410 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) C2U37_18415 ENOG4105E33 succinate dehydrogenase C2U37_18420 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C2U37_18425 ENOG4105C7S Dehydrogenase C2U37_18430 ENOG4105CMV Succinyl-CoA synthetase subunit beta C2U37_18435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C2U37_18460 ENOG4105C6N Formate acetyltransferase C2U37_18465 ENOG4105TMB Formate nitrite transporter C2U37_18470 ENOG4105DDY UPF0142 protein ycaO C2U37_18480 ENOG4105KPY Small multidrug resistance protein C2U37_18485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U37_18490 ENOG4105VEQ Cold shock protein C2U37_18495 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C2U37_18500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U37_18505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C2U37_18510 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate C2U37_18515 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C2U37_18520 ENOG4107MBR 17 kDa surface antigen C2U37_18525 ENOG4105BZU Histidine kinase C2U37_18530 ENOG4105C3M thioredoxin reductase C2U37_18535 ENOG4105DCF alanine dehydrogenase C2U37_18540 ENOG4105EW9 transcriptional regulator AsnC family C2U37_18545 ENOG4105CNU cell division protein FtsK C2U37_18550 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C2U37_18555 ENOG4105D1H recombination factor protein RarA C2U37_18565 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C2U37_18570 ENOG4105E96 Colicin v production protein C2U37_18575 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C2U37_18580 ENOG4105CS2 ec 3.2.1.21 C2U37_18585 ENOG4105C5Y PTS System C2U37_18590 ENOG4105DDV Transcriptional regulator (LacI family C2U37_18595 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase C2U37_18600 ENOG4108JQ2 peptide transport system atp-binding protein C2U37_18605 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein C2U37_18610 ENOG4108EU3 peptide transport system, permease C2U37_18615 ENOG4108I5W peptide transport system, permease protein C2U37_18620 ENOG4108J59 Extracellular solute-binding protein, family 5 C2U37_18625 ENOG4105E51 psp operon transcriptional activator C2U37_18630 ENOG41087YS Phage shock protein A C2U37_18635 ENOG4105YYT phage shock protein B C2U37_18645 ENOG4105CM6 amino acid regulated cytosolic protein C2U37_18650 ENOG4106K28 UPF0283 membrane protein C2U37_18655 ENOG4105MIR Phenylalanine 4-monooxygenase C2U37_18660 ENOG41090A4 Pterin carbinolamine dehydratase C2U37_18670 ENOG4108WS1 C2U37_18675 ENOG4108KHX Diguanylate cyclase C2U37_18680 ENOG41090EK ompa motb domain protein C2U37_18700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U37_18720 ENOG4105D7V transposase C2U37_18735 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U37_18740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U37_18760 ENOG41082F9 transcriptional regulator C2U37_18770 ENOG4105FQ6 thiopurine methyltransferase C2U37_18775 ENOG4107QXK peptidase C2U37_18780 ENOG4108BY2 phosphohistidine phosphatase C2U37_18790 ENOG4108IPJ Membrane C2U37_18795 ENOG4107QSI ABC, transporter C2U37_18800 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 C2U37_18805 ENOG4108JA2 transcriptioN-repair coupling factor C2U37_18815 ENOG4105D60 lipoprotein releasing system transmembrane protein C2U37_18820 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C2U37_18825 ENOG4105D60 lipoprotein releasing system transmembrane protein C2U37_18845 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C2U37_18850 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2U37_18855 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C2U37_18860 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2U37_18865 ENOG4105K70 DNA-binding protein C2U37_18870 ENOG4105EIN peptidylprolyl cis-trans isomerase C2U37_18875 ENOG4105C5H ABC transporter C2U37_18880 ENOG4107QN1 sodium solute C2U37_18885 ENOG41062QD Membrane C2U37_18900 ENOG41060WC Enoyl-CoA hydratase C2U37_18905 ENOG4105BZG amino acid carrier protein C2U37_18915 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) C2U37_18920 ENOG4106HK8 GPR1 FUN34 yaaH family protein C2U37_18945 ENOG4105E39 Enoyl-CoA hydratase C2U37_18950 ENOG4107QX3 carboxylase C2U37_18955 ENOG4105C1G acyl-Coa dehydrogenase C2U37_18960 ENOG4105C26 Dehydrogenase C2U37_18965 ENOG4105C1G acyl-Coa dehydrogenase C2U37_18970 ENOG4105E39 Enoyl-CoA hydratase C2U37_18975 ENOG4105E39 Enoyl-CoA hydratase C2U37_18980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U37_18990 ENOG4105D5Q Arginine ornithine antiporter C2U37_18995 ENOG4105HF0 Membrane C2U37_19010 ENOG41062B0 ABC transporter, permease C2U37_19015 ENOG4107R9N ABC transporter C2U37_19020 ENOG4105C2J ABC transporter C2U37_19025 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator C2U37_19030 ENOG4105DND Transcriptional regulator C2U37_19045 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C2U37_19050 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C2U37_19060 ENOG4105BZU Histidine kinase C2U37_19065 ENOG4108KB2 LysR family Transcriptional regulator C2U37_19070 ENOG4105CS2 ec 3.2.1.21 C2U37_19075 ENOG4105CHR reductase C2U37_19080 ENOG4105CBN LysR family transcriptional regulator C2U37_19095 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C2U37_19105 ENOG4105DUM transcriptional regulator, lysR family C2U37_19115 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase C2U37_19120 ENOG4105D1S lipid A biosynthesis C2U37_19130 ENOG4105EUB pirin domain protein C2U37_19135 ENOG4105CQ2 DNA polymerase C2U37_19165 ENOG4107QI1 Mate efflux family protein C2U37_19170 ENOG4105W1I UPF0253 protein C2U37_19175 ENOG4108R6K riboflavin synthase, subunit alpha C2U37_19190 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 C2U37_19195 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C2U37_19200 ENOG4108SXK Transporter Drug Metabolite Exporter family C2U37_19205 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C2U37_19235 ENOG4105D7V transposase C2U37_19240 ENOG4105QNR S1 RNA binding domain protein C2U37_19250 ENOG4105XW2 UPF0263 protein C2U37_19260 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase C2U37_19270 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) C2U37_19275 ENOG4107QMS site-determining protein C2U37_19280 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C2U37_19285 ENOG4105VNG YcgL domain-containing protein C2U37_19290 ENOG4105CVE Lytic murein transglycosylase C2U37_19295 ENOG4105EJQ L-serine dehydratase C2U37_19305 ENOG4105EJQ L-serine dehydratase C2U37_19310 ENOG4105NBK UPF0345 protein C2U37_19335 ENOG4105CHU acetyl-coa acetyltransferase C2U37_19340 ENOG4105D58 Diguanylate phosphodiesterase C2U37_19345 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation C2U37_19350 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation C2U37_19390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2U37_19395 ENOG4105CHU acetyl-coa acetyltransferase C2U37_19400 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U37_19410 ENOG4108VWS Yaeq family C2U37_19420 ENOG4105F2I Transposase C2U37_19440 ENOG4105EHG Permease protein C2U37_19455 ENOG4107MBR 17 kDa surface antigen C2U37_19460 ENOG4105CEY Amp-dependent synthetase and ligase C2U37_19475 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C2U37_19480 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C2U37_19485 ENOG4105BZU Histidine kinase C2U37_19495 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U37_19500 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C2U37_19505 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C2U37_19515 ENOG4105CIH Imidazole acetol-phosphate transaminase C2U37_19520 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C2U37_19525 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C2U37_19535 ENOG4105DVT helicase C2U37_19540 ENOG41072GX Peptidase M22 Glycoprotease C2U37_19550 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C2U37_19555 ENOG4105CEY Amp-dependent synthetase and ligase C2U37_19570 ENOG4105DXC membrane C2U37_19580 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) C2U37_19585 ENOG4105WD1 Membrane C2U37_19590 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C2U37_19595 ENOG4107QMP dna polymerase iii subunits gamma and tau C2U37_19600 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C2U37_19605 ENOG4105CR8 Transcriptional regulator C2U37_19610 ENOG4105EUB pirin domain protein C2U37_19615 ENOG4105DWD nucleoside recognition domain protein C2U37_19620 ENOG4105WH1 Two component transcriptional regulator luxr family C2U37_19630 ENOG4105CQ7 ATP-dependent helicase C2U37_19640 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C2U37_19655 ENOG4105C5X domain protein C2U37_19660 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C2U37_19665 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) C2U37_19670 ENOG4105FAT Acyl-transferase C2U37_19680 ENOG4105DR4 Methyltransferase C2U37_19685 ENOG4108N3W hemolysin secretion protein C2U37_19690 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 C2U37_19700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C2U37_19705 ENOG4105D1F ATP-binding protein C2U37_19710 ENOG4105DBI uridine monophosphokinase C2U37_19715 ENOG4105DHP deoxycytidine triphosphate deaminase C2U37_19720 ENOG4105CJ3 phosphate transporter C2U37_19745 ENOG4108VSE mercuric transport protein C2U37_19760 ENOG4105D13 transposase C2U37_19780 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_19790 ENOG4105C03 ribonuclease C2U37_19795 ENOG4105EI2 Pseudouridine synthase C2U37_19800 ENOG4108UHJ MAF-like protein C2U37_19810 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C2U37_19815 ENOG4105VGS 50s ribosomal protein l32 C2U37_19820 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C2U37_19825 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U37_19830 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C2U37_19835 ENOG4105CHR reductase C2U37_19840 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C2U37_19845 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2U37_19850 ENOG4105YAZ 4-amino-4-deoxychorismate lyase C2U37_19855 ENOG4105HHA aminodeoxychorismate lyase C2U37_19860 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C2U37_19865 ENOG4107QRG dna polymerase iii C2U37_19870 ENOG4105F8V Hydrolase, tatD family C2U37_19885 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2U37_19890 ENOG4105DY2 Paraquat-inducible protein b C2U37_19895 ENOG4105H2K paraquat-inducible protein a C2U37_19905 ENOG4105X2V dna damage-inducible protein C2U37_19915 ENOG4105DAN ATP-dependent protease C2U37_19920 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) C2U37_19925 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) C2U37_19935 ENOG4105C5H ABC transporter C2U37_19945 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C2U37_19950 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) C2U37_19955 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C2U37_19960 ENOG4105C7I Dehydrogenase C2U37_19970 ENOG4105CD8 aminopeptidase N C2U37_19975 ENOG4105CN1 protease C2U37_19980 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) C2U37_19985 ENOG4108ZGC gaf domain protein C2U37_19995 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C2U37_20010 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) C2U37_20020 ENOG4105C59 p-type ATPase C2U37_20035 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C2U37_20040 ENOG4105Q9Y Universal stress protein C2U37_20045 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C2U37_20060 ENOG4105D7V transposase C2U37_20070 ENOG4108K3A Glutathione S-transferase C2U37_20075 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C2U37_20080 ENOG4105C2J ABC transporter C2U37_20085 ENOG4105CNN ABC, transporter C2U37_20090 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C2U37_20095 ENOG4108RVA ribokinase C2U37_20100 ENOG4105ETE Transcriptional regulator (LacI family C2U37_20110 ENOG4105D7V transposase C2U37_20125 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2U37_20140 ENOG4105BZU Histidine kinase C2U37_20145 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C2U37_20150 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C2U37_20155 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C2U37_20175 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C2U37_20180 ENOG41083UC 50s ribosomal protein L35 C2U37_20185 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C2U37_20190 ENOG4105C22 threonyL-tRNA synthetase C2U37_20210 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U37_20215 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C2U37_20220 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U37_20225 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U37_20230 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U37_20235 ENOG4105XPH Ferredoxin C2U37_20240 ENOG4105CA3 membrane-bound lytic murein transglycosylase C2U37_20245 ENOG4105XZD Fe-S protein C2U37_20250 ENOG4105DM4 PTS System C2U37_20255 ENOG4105DE4 1-phosphofructokinase C2U37_20260 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein C2U37_20265 ENOG4107B7Y DNA-binding transcriptional regulator FruR C2U37_20270 ENOG4105E0U tyrosine-specific transport protein C2U37_20285 ENOG4105C1J atp-dependent rna helicase C2U37_20295 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C2U37_20300 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) C2U37_20305 ENOG4108DG9 Smr protein MutS2 C2U37_20340 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C2U37_20370 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2U37_20395 ENOG4105K6T rare lipoprotein A C2U37_20400 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) C2U37_20405 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) C2U37_20410 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) C2U37_20415 ENOG4106371 Methyltransferase C2U37_20420 ENOG4107S90 membrAne C2U37_20430 ENOG4105CTQ phosphohexokinase C2U37_20440 ENOG4105EQR Transposase IS116 IS110 IS902 C2U37_20450 ENOG4105CH2 amidohydrolase C2U37_20460 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U37_20505 ENOG4105CPB ATP-dependent endonuclease of the OLD family C2U37_20520 ENOG4105VP0 transcriptional regulator, lysR family C2U37_20525 ENOG4105EJ9 Membrane C2U37_20530 ENOG4106IUH DTW domain containing protein C2U37_20535 ENOG4105CPF Cell wall formation (By similarity) C2U37_20550 ENOG4105C1J atp-dependent rna helicase C2U37_20555 ENOG4105K5X acetyltransferase C2U37_20565 ENOG4105KK4 UPF0060 membrane protein C2U37_20590 ENOG41061CK Antibiotic biosynthesis monooxygenase C2U37_20595 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) C2U37_20615 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C2U37_20625 ENOG4105WQ3 Rna-binding protein C2U37_20640 ENOG4105BZ1 (ABC) transporter C2U37_20645 ENOG4105BZ1 (ABC) transporter C2U37_20650 ENOG4105BZU Histidine kinase C2U37_20655 ENOG4105K63 Thioredoxin C2U37_20660 ENOG4105C8P )-transporter C2U37_20670 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) C2U37_20690 ENOG4105CRQ synthase (Component I) C2U37_20700 ENOG4105C44 Serine transporter C2U37_20705 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) C2U37_20710 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U37_20715 ENOG4105CYN Serine protein kinase C2U37_20720 ENOG4106AKX UPF0229 protein C2U37_20725 ENOG4105ED1 spovr family C2U37_20730 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) C2U37_20735 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C2U37_20740 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C2U37_20745 ENOG4105DQR SNARE associated Golgi C2U37_20755 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C2U37_20770 ENOG4105D0C transport protein C2U37_20775 ENOG4105E4C Lytic transglycosylase catalytic C2U37_20795 ENOG4108MRH transcriptional regulatory protein C2U37_20805 ENOG4105E2R ROK family C2U37_20810 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_20820 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A C2U37_20825 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B C2U37_20830 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U37_20855 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit C2U37_20860 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U37_20865 ENOG4105DVI reductase, NrfD C2U37_20870 ENOG4105DA4 cytochrome c-type biogenesis protein C2U37_20875 ENOG4107QX9 Thiol disulfide interChange protein C2U37_20880 ENOG4108DMF Cytochrome C biogenesis protein C2U37_20885 ENOG41061WM D-Alanyl-D-Alanine C2U37_20895 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein C2U37_20900 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U37_20915 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U37_20925 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2U37_20930 ENOG4105DZ2 Transcriptional regulator C2U37_20940 ENOG4105E0K tonB-dependent siderophore receptor C2U37_20945 ENOG4105BZU Histidine kinase C2U37_20950 ENOG4105BZU Histidine kinase C2U37_20955 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C2U37_20960 ENOG4105CR8 Transcriptional regulator C2U37_20965 ENOG4108RYK Nad-dependent epimerase dehydratase C2U37_20980 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C2U37_21010 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2U37_21050 ENOG4105P8Q Curli production assembly transport component CsgG C2U37_21060 ENOG4108XDW curli assembly protein CsgE C2U37_21065 ENOG41086KC Transcriptional regulator C2U37_21080 ENOG4105F2I Transposase C2U37_21120 ENOG4105F2I Transposase C2U37_21130 ENOG4105F5W AtP-binding protein C2U37_21135 ENOG4105D70 Integrase catalytic subunit C2U37_21180 ENOG4105CAF HipA N-terminal domain protein C2U37_21195 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) C2U37_21200 ENOG4105E98 transcriptional regulator DeoR family C2U37_21215 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2U37_21225 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein C2U37_21245 ENOG4105F2I Transposase C2U37_21255 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_21270 ENOG4108RMJ sensory transduction regulator C2U37_21280 ENOG4107104 thymidine kinase C2U37_21285 ENOG4107S6Z Na H antiporter C2U37_21295 ENOG4108WBT adenosyltransferase C2U37_21305 ENOG4105VRT cytoplasmic protein C2U37_21310 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C2U37_21315 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C2U37_21330 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C2U37_21335 ENOG4105CFV Tetratricopeptide repeat protein C2U37_21345 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C2U37_21350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C2U37_21355 ENOG4105CAT Cytidine monophosphate kinase C2U37_21360 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) C2U37_21365 ENOG4105DUM transcriptional regulator, lysR family C2U37_21370 ENOG4105D2S major facilitator superfamily C2U37_21385 ENOG4108DBC nitroreductase C2U37_21390 ENOG4105CFC Transporter C2U37_21395 ENOG4105BZU Histidine kinase C2U37_21405 ENOG4105CBN LysR family transcriptional regulator C2U37_21410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U37_21435 ENOG4107RGM aldo keto reductase C2U37_21440 ENOG4105VFU Rna-binding protein C2U37_21450 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) C2U37_21460 ENOG4105HA9 of methanol dehydrogenase type C2U37_21480 ENOG4105E14 MotA TolQ exbB proton channel C2U37_21485 ENOG4105ER2 Ompa motb domain protein C2U37_21490 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2U37_21495 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U37_21500 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U37_21505 ENOG4105GKE subunit e C2U37_21510 ENOG4107QIZ NADH dehydrogenase C2U37_21515 ENOG4108IEH NADH dehydrogenase subunit g C2U37_21520 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C2U37_21525 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U37_21530 ENOG4107UFS subunit j C2U37_21535 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U37_21540 ENOG4105D65 subunit l C2U37_21545 ENOG4105C8S subunit m C2U37_21550 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U37_21555 ENOG4107QIK phosphoribosylformylglycinamidine synthase C2U37_21560 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C2U37_21565 ENOG4105VPD cellular component movement C2U37_21570 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C2U37_21575 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U37_21580 ENOG4105N21 Membrane C2U37_21585 ENOG4105CUT histidyl-tRNA synthetase C2U37_21590 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C2U37_21595 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C2U37_21605 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C2U37_21610 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C2U37_21615 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U37_21625 ENOG4108ZIT Ferredoxin, 2FE-2S C2U37_21630 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB C2U37_21635 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) C2U37_21640 ENOG4108Z4V iron-sulfur cluster assembly C2U37_21645 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C2U37_21650 ENOG4105C3J Cysteine desulfurase C2U37_21655 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C2U37_21660 ENOG4105CVS RNA methyltransferase TrmH family, group 1 C2U37_21665 ENOG4105XPQ lipid carrier protein C2U37_21670 ENOG4105CFP Peptidase U32 C2U37_21675 ENOG4106RZ4 Peptidase U32 C2U37_21685 ENOG4105KHC sulfurtransferase C2U37_21690 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U37_21695 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U37_21700 ENOG4105VIE preprotein translocase, subunit YajC C2U37_21705 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C2U37_21710 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C2U37_21715 ENOG4105W87 Cbs domain C2U37_21720 ENOG4105D3R alkyl hydroperoxide reductase C2U37_21765 ENOG4107SID ATP-dependent exodnase (exonuclease v) C2U37_21815 ENOG4105D70 Integrase catalytic subunit C2U37_21820 ENOG4105F5W AtP-binding protein C2U37_21835 ENOG4105F2I Transposase C2U37_21840 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C2U37_21845 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C2U37_21850 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C2U37_21855 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C2U37_21860 ENOG4105D0A hydroxylase C2U37_21870 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C2U37_21880 ENOG4105E5M Multidrug resistance protein D C2U37_21885 ENOG4105C3U ABC transporter C2U37_21890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U37_21895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U37_21905 ENOG4105CYM Glutathione S-transferase C2U37_21910 ENOG4108K3A Glutathione S-transferase C2U37_21925 ENOG4105EIY sodium-type flagellar protein motY C2U37_21935 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) C2U37_21940 ENOG4105D3Y Na H antiporter C2U37_21950 ENOG4105CC0 LysR family Transcriptional regulator C2U37_21970 ENOG4105KA0 thioesterase Superfamily protein C2U37_21980 ENOG4105CQB FAD linked oxidase domain protein C2U37_21995 ENOG4105EE5 Membrane protein terC C2U37_22000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U37_22010 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C2U37_22015 ENOG4105D4U had-superfamily hydrolase, subfamily iia C2U37_22025 ENOG4105CAQ asparagine synthetase C2U37_22040 ENOG4108RXX maleylacetoacetate isomerase C2U37_22050 ENOG4105F1J Homogentisate 1,2-dioxygenase C2U37_22055 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C2U37_22065 ENOG4108W1A pseudouridine synthase C2U37_22075 ENOG4105BZU Histidine kinase C2U37_22095 ENOG4105CR4 methylisocitrate lyase C2U37_22100 ENOG4105BZN citrate synthase C2U37_22105 ENOG4108I0Z Aconitate hydratase C2U37_22110 ENOG4105C7F AcnD-accessory protein PrpF C2U37_22125 ENOG4105CNM Receptor C2U37_22135 ENOG4108MN8 Membrane C2U37_22140 ENOG4105EM2 membrane C2U37_22145 ENOG4108Z0T Part of a sulfur-relay system (By similarity) C2U37_22150 ENOG4108S3P Sporulation domain protein C2U37_22155 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C2U37_22160 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C2U37_22165 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C2U37_22175 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U37_22180 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) C2U37_22190 ENOG4105D01 (LipO)protein C2U37_22215 ENOG4105DKW ABC transporter C2U37_22220 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2U37_22225 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C2U37_22235 ENOG4105C85 amino acid C2U37_22270 ENOG4105C42 Type I secretion membrane fusion protein (HlyD C2U37_22280 ENOG4105N5T Radical SAM Protein C2U37_22285 ENOG4105CBC glutamate synthase C2U37_22290 ENOG4105BZ8 glutamate synthase C2U37_22295 ENOG4105CDA abc transporter atp-binding protein C2U37_22300 ENOG4105DRP amino acid AbC transporter C2U37_22305 ENOG4105EAB amino acid AbC transporter C2U37_22340 ENOG4105C1J atp-dependent rna helicase C2U37_22370 ENOG4107QS8 (LipO)protein C2U37_22375 ENOG4106TD9 Diguanylate cyclase C2U37_22380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2U37_22455 ENOG4106NZI LysR family Transcriptional regulator C2U37_22480 ENOG4105KPY Small multidrug resistance protein C2U37_22520 ENOG4107QJE Chromosome Partitioning Protein C2U37_22600 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2U37_22615 ENOG4105DFS Conserved Protein C2U37_22630 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C2U37_22635 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C2U37_22640 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C2U37_22650 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C2U37_22655 ENOG4105E66 phosphoriboisomerase A C2U37_22660 ENOG4108JQ1 Dehydrogenase C2U37_22665 ENOG41080IJ Diacylglycerol kinase C2U37_22670 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U37_22680 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) C2U37_22700 ENOG4105CZX twitching motility protein C2U37_22710 ENOG4105CE1 Ferrous iron transport protein b C2U37_22720 ENOG4108ZJT translation initiation factor, Sui1 C2U37_22760 ENOG410620I Diguanylate cyclase C2U37_22770 ENOG4105F2I Transposase C2U37_22780 ENOG4105C8N cysteinyl-tRNA synthetase C2U37_22785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C2U37_22795 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C2U37_22800 ENOG4105Y3U Transglycosylase-associated protein C2U37_22805 ENOG4108WUH Transcriptional regulator, TetR family C2U37_22810 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family C2U37_22820 ENOG4108J1Q C2U37_22830 ENOG4107R3N Filamentation induced by cAMP protein fic C2U37_22910 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2U37_22915 ENOG4105WH1 Two component transcriptional regulator luxr family C2U37_22920 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C2U37_22925 ENOG4105W49 UPF0434 protein C2U37_22930 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C2U37_22935 ENOG4105BZ1 (ABC) transporter C2U37_22940 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 C2U37_22955 ENOG4105D7A ATP-binding protein C2U37_22960 ENOG4105CGF Aromatic amino acid aminotransferase C2U37_22975 ENOG4105VNT transposase (IS4 family) protein C2U37_22985 ENOG4105DVT helicase C2U37_22995 ENOG4105DGU Histone deacetylase C2U37_23000 ENOG4108ISG Major Facilitator C2U37_23005 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C2U37_23010 ENOG4105G6Z alkaline phosphatase C2U37_23030 ENOG4105NXH GreA GreB family elongation factor C2U37_23035 ENOG4105BZU Histidine kinase C2U37_23040 ENOG4106TNF Periplasmic binding protein C2U37_23045 ENOG4105E5Q amino acid AbC transporter C2U37_23050 ENOG4105CDA abc transporter atp-binding protein C2U37_23060 ENOG4105D5Q Arginine ornithine antiporter C2U37_23065 ENOG4105C3R Methionine synthase C2U37_23075 ENOG4105C37 (CBS) domain C2U37_23085 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2U37_23090 ENOG4105E2Z phosphate ABC transporter (Permease C2U37_23095 ENOG4105C8U phosphate abc transporter C2U37_23100 ENOG4108Z6B deaminase C2U37_23115 ENOG4107QP3 malate synthase g C2U37_23120 ENOG4108I9X Isocitrate lyase C2U37_23135 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C2U37_23140 ENOG4105CXB phosphoribosylaminoimidazole synthetase C2U37_23145 ENOG4108V3E phosphoribosylglycinamide formyltransferase C2U37_23150 ENOG4107QNR UPF0135 protein C2U37_23155 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_23160 ENOG4105BZU Histidine kinase C2U37_23165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U37_23175 ENOG4105RH4 Glycine cleavage system transcriptional repressor C2U37_23180 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C2U37_23185 ENOG4105C9X ppx gppa phosphatase C2U37_23190 ENOG4105CJW magnesium transporter C2U37_23205 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C2U37_23210 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U37_23215 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U37_23220 ENOG4105CGA flagellar basal-body rod protein FlgG C2U37_23225 ENOG4108KPB Flagellar basal-body rod protein FlgF C2U37_23230 ENOG4105BZE flagellar hook protein, FlgE C2U37_23240 ENOG4108ZC9 flagellar basal-body rod protein flgc C2U37_23245 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2U37_23250 ENOG4105BZU Histidine kinase C2U37_23255 ENOG4107R88 Chemotaxis protein (CheV) C2U37_23260 ENOG4107ESN Flagella basal body P-ring formation protein flgA C2U37_23275 ENOG4108RE9 Phosphodiesterase C2U37_23280 ENOG4107QSI ABC, transporter C2U37_23290 ENOG4105I08 Pseudouridine synthase C2U37_23295 ENOG4105DHT Metal Dependent Phosphohydrolase C2U37_23305 ENOG4108594 Permease of the drug metabolite transporter C2U37_23310 ENOG4105E43 Extracellular solute-binding protein, family 5 C2U37_23335 ENOG4105VEQ Cold shock protein C2U37_23340 ENOG4107QSN dihydrolipoamide acetyltransferase C2U37_23345 ENOG4105CPP Dehydrogenase, E1 component C2U37_23350 ENOG4107RUY (E1 component), alpha subunit C2U37_23365 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) C2U37_23375 ENOG4108YXG UPF0502 protein C2U37_23385 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) C2U37_23390 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C2U37_23400 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2U37_23415 ENOG4105CG5 Glycosyl transferase (Group 1 C2U37_23420 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide C2U37_23425 ENOG4108MY6 biosynthesis protein C2U37_23440 ENOG4105F0R Cytidylyltransferase C2U37_23445 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C2U37_23450 ENOG4108S0S Nucleotidyl transferase C2U37_23460 ENOG4105D2T synthase C2U37_23465 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase C2U37_23470 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C2U37_23480 ENOG4105C1B dTDP-glucose 4-6-dehydratase C2U37_23485 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U37_23500 ENOG4106KNT transcriptional regulator C2U37_23505 ENOG4105CA9 Pyruvate kinase C2U37_23515 ENOG4105BZS acriflavin resistance protein C2U37_23520 ENOG4107QPN acyl-Coa dehydrogenase C2U37_23530 ENOG4107SSZ Phosphatase C2U37_23545 ENOG4108P8R C2U37_23570 ENOG4105D70 Integrase catalytic subunit C2U37_23575 ENOG4105F5W AtP-binding protein C2U37_23590 ENOG4105F2I Transposase C2U37_23605 ENOG4105C0D helicase C2U37_23630 ENOG4105DZR Type I site-specific deoxyribonuclease C2U37_23670 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U37_23685 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2U37_23690 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U37_23695 ENOG4105BZS acriflavin resistance protein C2U37_23700 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U37_23705 ENOG4108IG5 Transcriptional regulator C2U37_23720 ENOG4105C29 acyl-CoA thioesterase C2U37_23730 ENOG4105FE9 pseudouridine synthase C2U37_23735 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C2U37_23745 ENOG4107RTD sua5 ycio yrdc ywlc family protein C2U37_23750 ENOG4105DB7 PHP domain protein C2U37_23755 ENOG4105CRQ synthase (Component I) C2U37_23760 ENOG4108EFP Anthranilate synthase component II C2U37_23765 ENOG4108I0Q anthranilate phosphoribosyltransferase C2U37_23770 ENOG4105DK0 Indole-3-glycerol phosphate synthase C2U37_23775 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C2U37_23780 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C2U37_23790 ENOG4105F2I Transposase C2U37_23815 ENOG4105JQN Transcriptional regulator C2U37_23825 ENOG4106FTQ Taurine ABC transporter, periplasmic C2U37_23830 ENOG4108ETV ABC transporter C2U37_23835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U37_23840 ENOG4105E2B Taurine dioxygenase C2U37_23850 ENOG4105KCV RNA signal recognition particle 4.5S RNA C2U37_23855 ENOG4107RDB Major Facilitator C2U37_23860 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2U37_23865 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C2U37_23870 ENOG4105CCU oxidase (Subunit III) C2U37_23875 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2U37_23880 ENOG4105E2S oxidase) subunit II C2U37_23890 ENOG4105CC0 LysR family Transcriptional regulator C2U37_23910 ENOG4105NTK Transcriptional repressor Mpra C2U37_23925 ENOG41090JD Blue (Type 1) copper domain protein C2U37_23945 ENOG4105K4U addiction module toxin, RelE StbE family C2U37_23955 ENOG4107SKI cobyrinic Acid a,c-diamide synthase C2U37_23975 ENOG4105C8Q Methyl-accepting chemotaxis C2U37_24135 ENOG4105F9F transposase C2U37_24150 ENOG4105F9F transposase C2U37_24160 ENOG4105F9F transposase C2U37_24175 ENOG4108C33 Resolvase C2U37_24190 ENOG4105F9F transposase C2U37_24375 ENOG4105D13 transposase C2U37_24390 ENOG4108VSE mercuric transport protein C2U37_24455 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U37_24495 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor