locus-tag	class	description
C2U37_00015	COG0708	Exodeoxyribonuclease III
C2U37_00025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_00030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_00045	COG0095	Lipoate-protein ligase
C2U37_00065	COG2391	methyltransferase activity
C2U37_00075	COG0640	Transcriptional regulator
C2U37_00085	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_00095	COG1285	pathogenesis
C2U37_00125	COG0484	heat shock protein binding
C2U37_00130	COG0443	Heat shock 70 kDa protein
C2U37_00135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U37_00140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U37_00145	COG3706	GGDEF domain
C2U37_00150	COG0497	DNA recombination
C2U37_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_00165	COG0577	efflux transmembrane transporter activity
C2U37_00165	COG1136	(ABC) transporter
C2U37_00170	COG1538	Outer membrane efflux protein
C2U37_00175	COG2375	cellular response to nickel ion
C2U37_00180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_00185	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_00190	COG0583	DNA-binding transcription factor activity
C2U37_00195	COG3048	D-serine ammonia-lyase activity
C2U37_00205	COG0538	isocitrate dehydrogenase activity
C2U37_00235	COG0456	acetyltransferase
C2U37_00240	COG1187	pseudouridine synthase activity
C2U37_00250	COG0482	sulfurtransferase activity
C2U37_00255	COG2915	High frequency lysogenization protein hflD homolog
C2U37_00260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U37_00265	COG2850	peptidyl-arginine hydroxylation
C2U37_00275	COG3264	Mechanosensitive ion channel
C2U37_00275	COG1196	nuclear chromosome segregation
C2U37_00305	COG0281	malic enzyme
C2U37_00310	COG0746	molybdenum cofactor guanylyltransferase activity
C2U37_00315	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U37_00320	COG1289	transmembrane transporter activity
C2U37_00325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_00355	COG3220	belongs to the UPF0276 family
C2U37_00365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U37_00380	COG3039	Transposase
C2U37_00400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U37_00405	COG0083	homoserine kinase activity
C2U37_00420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U37_00425	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U37_00440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U37_00450	COG0745	RESPONSE REGULATOR receiver
C2U37_00465	COG4988	ABC transporter
C2U37_00470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U37_00490	COG1720	tRNA m6t6A37 methyltransferase activity
C2U37_00505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U37_00510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U37_00515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_00525	COG2190	(PTS) system
C2U37_00540	COG0420	3'-5' exonuclease activity
C2U37_00545	COG1247	-acetyltransferase
C2U37_00550	COG2974	May be involved in recombination
C2U37_00560	COG0405	Gamma-glutamyltransferase
C2U37_00565	COG4651	solute:proton antiporter activity
C2U37_00565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U37_00600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_00605	COG1917	Cupin 2, conserved barrel domain protein
C2U37_00605	COG1396	sequence-specific DNA binding
C2U37_00625	COG0531	amino acid
C2U37_00630	COG0531	amino acid
C2U37_00640	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U37_00650	COG3384	dioxygenase
C2U37_00680	COG2205	protein histidine kinase activity
C2U37_00680	COG0784	Response regulator, receiver
C2U37_00690	COG1388	LysM domain
C2U37_00690	COG1376	ErfK ybiS ycfS ynhG family protein
C2U37_00705	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U37_00710	COG0791	NLP P60 protein
C2U37_00720	COG3118	belongs to the thioredoxin family
C2U37_00730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U37_00735	COG0788	formyltetrahydrofolate deformylase activity
C2U37_00760	COG0739	heme binding
C2U37_00760	COG1196	nuclear chromosome segregation
C2U37_00760	COG0741	lytic transglycosylase activity
C2U37_00770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U37_00775	COG0673	inositol 2-dehydrogenase activity
C2U37_00815	COG1032	radical SAM domain protein
C2U37_00820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_00830	COG3706	GGDEF domain
C2U37_00835	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U37_00840	COG0733	neurotransmitter:sodium symporter activity
C2U37_00870	COG0281	malic enzyme
C2U37_00875	COG2207	Transcriptional regulator
C2U37_00880	COG0534	Mate efflux family protein
C2U37_00890	COG0745	RESPONSE REGULATOR receiver
C2U37_00890	COG3706	GGDEF domain
C2U37_00895	COG2233	PERMEase
C2U37_00900	COG0095	Lipoate-protein ligase
C2U37_00905	COG1115	amino acid carrier protein
C2U37_00910	COG0019	diaminopimelate decarboxylase activity
C2U37_00920	COG0678	peroxiredoxin activity
C2U37_00925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U37_00935	COG1126	abc transporter atp-binding protein
C2U37_00940	COG0765	amino acid transport
C2U37_00945	COG4597	amino acid ABC transporter
C2U37_00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_00965	COG1131	(ABC) transporter
C2U37_00970	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U37_00985	COG1940	carbohydrate kinase activity
C2U37_00995	COG4783	chaperone-mediated protein folding
C2U37_01005	COG5002	protein histidine kinase activity
C2U37_01010	COG0745	RESPONSE REGULATOR receiver
C2U37_01015	COG0346	lactoylglutathione lyase activity
C2U37_01020	COG3706	GGDEF domain
C2U37_01025	COG3284	Transcriptional regulator
C2U37_01030	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_01040	COG0697	spore germination
C2U37_01050	COG0667	Aldo Keto reductase
C2U37_01065	COG3290	protein histidine kinase activity
C2U37_01080	COG4644	lycopene metabolic process
C2U37_01095	COG0840	transmembrane signaling receptor activity
C2U37_01180	COG1475	DNA binding
C2U37_01195	COG5489	Protein of unknown function (DUF736)
C2U37_01250	COG4959	Type IV secretory pathway protease TraF
C2U37_01265	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U37_01285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_01290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_01305	COG0583	DNA-binding transcription factor activity
C2U37_01325	COG4962	Type ii secretion system protein e
C2U37_01330	COG3838	Conjugal transfer protein Trbc
C2U37_01340	COG3451	type IV secretory pathway VirB4
C2U37_01355	COG3846	protein secretion by the type IV secretion system
C2U37_01395	COG0602	queuosine metabolic process
C2U37_01400	COG1328	CTP reductase activity
C2U37_01410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U37_01415	COG3115	cell septum assembly
C2U37_01430	COG2860	membrane
C2U37_01440	COG3108	Peptidase M15
C2U37_01445	COG2989	Protein conserved in bacteria
C2U37_01460	COG0463	Glycosyl transferase, family 2
C2U37_01475	COG0366	Alpha amylase catalytic
C2U37_01515	COG3706	GGDEF domain
C2U37_01520	COG0037	tRNA processing
C2U37_01525	COG3590	peptidase
C2U37_01535	COG0488	(ABC) transporter
C2U37_01545	COG0531	amino acid
C2U37_01550	COG0814	amino acid
C2U37_01565	COG0825	malonyl-CoA metabolic process
C2U37_01575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U37_01580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_01585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_01590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U37_01595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_01610	COG0750	zinc metalloprotease
C2U37_01615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U37_01620	COG0575	Belongs to the CDS family
C2U37_01630	COG0233	cytoplasmic translational termination
C2U37_01635	COG0528	UMP kinase activity
C2U37_01640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U37_01645	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U37_01650	COG0024	Methionine aminopeptidase
C2U37_01655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U37_01660	COG2171	N-acyltransferase activity
C2U37_01670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_01670	COG1263	PTS System
C2U37_01695	COG0564	pseudouridine synthase activity
C2U37_01700	COG3098	single-species biofilm formation
C2U37_01725	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U37_01735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U37_01735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U37_01745	COG3706	GGDEF domain
C2U37_01750	COG1611	Belongs to the LOG family
C2U37_01755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_01760	COG0473	3-isopropylmalate dehydrogenase activity
C2U37_01770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U37_01785	COG0583	DNA-binding transcription factor activity
C2U37_01790	COG0840	transmembrane signaling receptor activity
C2U37_01795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_01810	COG1477	protein flavinylation
C2U37_01815	COG2871	sodium ion transport
C2U37_01820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_01825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_01830	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_01835	COG1805	sodium ion transport
C2U37_01840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_01845	COG0271	Belongs to the BolA IbaG family
C2U37_01850	COG2813	Specifically methylates the guanine in position
C2U37_01860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U37_01870	COG2211	Major facilitator Superfamily
C2U37_01880	COG1666	GTP binding
C2U37_01885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U37_01895	COG0659	secondary active sulfate transmembrane transporter activity
C2U37_01910	COG2723	6-phospho-beta-galactosidase activity
C2U37_01915	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U37_01935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U37_01945	COG1151	hydroxylamine reductase activity
C2U37_01950	COG0783	Belongs to the Dps family
C2U37_01975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U37_01990	COG4221	oxidoreductase activity
C2U37_02000	COG0415	Belongs to the DNA photolyase family
C2U37_02005	COG0789	Transcriptional regulator
C2U37_02010	COG3272	Protein of unknown function (DUF1722)
C2U37_02035	COG0077	Prephenate dehydratase
C2U37_02035	COG1605	Chorismate mutase
C2U37_02065	COG2133	pyrroloquinoline quinone binding
C2U37_02075	COG1349	DNA-binding transcription factor activity
C2U37_02080	COG2084	Dehydrogenase
C2U37_02085	COG3395	kinase activity
C2U37_02090	COG0235	Class ii aldolase
C2U37_02095	COG3622	Belongs to the hyi family
C2U37_02100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U37_02105	COG2610	gluconate transmembrane transporter activity
C2U37_02125	COG0300	oxidoreductase activity
C2U37_02150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U37_02170	COG3813	Protein conserved in bacteria
C2U37_02180	COG0826	peptidase U32
C2U37_02185	COG1280	lysine exporter protein (LysE YggA)
C2U37_02220	COG2200	EAL domain
C2U37_02220	COG2199	diguanylate cyclase activity
C2U37_02220	COG2203	Gaf domain
C2U37_02265	COG1566	PFAM secretion protein HlyD family protein
C2U37_02275	COG0114	fumarate hydratase activity
C2U37_02285	COG0506	proline dehydrogenase activity
C2U37_02285	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U37_02285	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U37_02290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_02295	COG0305	Participates in initiation and elongation during chromosome replication
C2U37_02305	COG0737	Belongs to the 5'-nucleotidase family
C2U37_02325	COG2204	response regulator
C2U37_02330	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U37_02340	COG2900	Belongs to the SlyX family
C2U37_02345	COG1047	Peptidyl-prolyl cis-trans
C2U37_02350	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U37_02360	COG0835	chemotaxis
C2U37_02360	COG0784	Response regulator, receiver
C2U37_02365	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U37_02370	COG4251	negative regulation of phosphorylation
C2U37_02370	COG3706	GGDEF domain
C2U37_02370	COG2203	Gaf domain
C2U37_02370	COG5001	Diguanylate cyclase
C2U37_02375	COG3089	Belongs to the UPF0270 family
C2U37_02380	COG3954	Phosphoribulokinase
C2U37_02395	COG1765	OsmC-like protein
C2U37_02400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U37_02405	COG2226	methyltransferase
C2U37_02415	COG2202	Pas domain
C2U37_02415	COG2205	protein histidine kinase activity
C2U37_02420	COG2814	Major facilitator Superfamily
C2U37_02445	COG0748	coenzyme F420 binding
C2U37_02450	COG3721	Heme iron utilization protein
C2U37_02460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_02485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U37_02495	COG0463	Glycosyl transferase, family 2
C2U37_02505	COG0741	lytic transglycosylase activity
C2U37_02595	COG0616	signal peptide processing
C2U37_02610	COG4626	Terminase
C2U37_02610	COG1802	Transcriptional regulator
C2U37_02645	COG4416	COG NOG18757 non supervised orthologous group
C2U37_02660	COG2135	peptidase activity
C2U37_02665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_02670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_02800	COG3173	Aminoglycoside phosphotransferase
C2U37_02835	COG0582	viral genome integration into host DNA
C2U37_02840	COG0488	(ABC) transporter
C2U37_02850	COG2252	PERMEase
C2U37_02855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U37_02860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U37_02865	COG3178	'Phosphotransferase
C2U37_02870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U37_02885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U37_02895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U37_02910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_02920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U37_02925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U37_02930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U37_02935	COG0142	geranyltranstransferase activity
C2U37_02940	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U37_02945	COG0330	HflC and HflK could
C2U37_02950	COG0330	HflC and HflK could
C2U37_02955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U37_02960	COG1923	regulation of RNA biosynthetic process
C2U37_02965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U37_02970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U37_02980	COG0802	atpase or kinase
C2U37_02985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U37_02985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U37_03005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U37_03010	COG2011	ABC-type metal ion transport system permease component
C2U37_03015	COG1464	Belongs to the NlpA lipoprotein family
C2U37_03035	COG0784	Response regulator, receiver
C2U37_03035	COG2205	protein histidine kinase activity
C2U37_03050	COG0784	Response regulator, receiver
C2U37_03050	COG5002	protein histidine kinase activity
C2U37_03050	COG2198	Histidine kinase
C2U37_03070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U37_03085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U37_03090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U37_03095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U37_03100	COG2716	regulation of RNA biosynthetic process
C2U37_03105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U37_03110	COG3013	Belongs to the UPF0304 family
C2U37_03115	COG3092	negative regulation of chromosome organization
C2U37_03120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U37_03125	COG0280	phosphate acetyltransferase
C2U37_03125	COG0857	belongs to the CobB CobQ family
C2U37_03130	COG0440	acetolactate synthase activity
C2U37_03135	COG0028	Belongs to the TPP enzyme family
C2U37_03150	COG0671	phosphoesterase, PA-phosphatase related
C2U37_03160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U37_03165	COG0473	3-isopropylmalate dehydrogenase activity
C2U37_03170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U37_03175	COG0066	3-isopropylmalate dehydratase activity
C2U37_03190	COG4143	(ABC) transporter
C2U37_03195	COG1178	ABC-type Fe3 transport system permease component
C2U37_03200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U37_03205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U37_03280	COG3385	transposase activity
C2U37_03285	COG2205	protein histidine kinase activity
C2U37_03290	COG0745	RESPONSE REGULATOR receiver
C2U37_03295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_03300	COG0577	efflux transmembrane transporter activity
C2U37_03300	COG1136	(ABC) transporter
C2U37_03310	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U37_03345	COG2203	Gaf domain
C2U37_03345	COG2199	diguanylate cyclase activity
C2U37_03350	COG0513	Belongs to the DEAD box helicase family
C2U37_03360	COG2207	Transcriptional regulator
C2U37_03360	COG1917	Cupin 2, conserved barrel domain protein
C2U37_03390	COG2801	Transposase and inactivated derivatives
C2U37_03395	COG0154	amidase activity
C2U37_03400	COG2957	Belongs to the agmatine deiminase family
C2U37_03415	COG1902	pentaerythritol trinitrate reductase activity
C2U37_03420	COG0456	acetyltransferase
C2U37_03445	COG5002	protein histidine kinase activity
C2U37_03445	COG5001	Diguanylate cyclase
C2U37_03450	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2U37_03465	COG0456	acetyltransferase
C2U37_03475	COG1022	Amp-dependent synthetase and ligase
C2U37_03500	COG1794	racemase activity, acting on amino acids and derivatives
C2U37_03515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_03530	COG0733	neurotransmitter:sodium symporter activity
C2U37_03535	COG0733	neurotransmitter:sodium symporter activity
C2U37_03550	COG0561	phosphatase activity
C2U37_03565	COG1522	sequence-specific DNA binding
C2U37_03580	COG1846	Transcriptional regulator
C2U37_03585	COG2130	NADP-dependent
C2U37_03615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U37_03620	COG1640	4-alpha-glucanotransferase
C2U37_03625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U37_03630	COG3385	transposase activity
C2U37_03640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U37_03645	COG0840	transmembrane signaling receptor activity
C2U37_03720	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U37_03725	COG2885	chlorophyll binding
C2U37_03730	COG0823	Involved in the tonB-independent uptake of proteins
C2U37_03745	COG0811	peptide transport
C2U37_03750	COG0824	Thioesterase
C2U37_03755	COG3790	cyd operon protein YbgE
C2U37_03760	COG4890	Cyd operon protein YbgT
C2U37_03765	COG1294	oxidase, subunit
C2U37_03770	COG1271	oxidase subunit
C2U37_03775	COG2255	four-way junction helicase activity
C2U37_03780	COG0632	four-way junction helicase activity
C2U37_03790	COG0442	prolyl-tRNA aminoacylation
C2U37_03795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_03800	COG4221	oxidoreductase activity
C2U37_03815	COG1024	Enoyl-CoA hydratase
C2U37_03830	COG4166	transmembrane transport
C2U37_03840	COG0840	transmembrane signaling receptor activity
C2U37_03845	COG0513	Belongs to the DEAD box helicase family
C2U37_03880	COG3118	belongs to the thioredoxin family
C2U37_03880	COG0457	Tetratricopeptide repeat
C2U37_03890	COG1215	transferase activity, transferring glycosyl groups
C2U37_03910	COG2194	sulfuric ester hydrolase activity
C2U37_03915	COG1448	Aminotransferase
C2U37_03935	COG1328	CTP reductase activity
C2U37_03960	COG0840	transmembrane signaling receptor activity
C2U37_03965	COG3397	chitin binding
C2U37_03970	COG0583	DNA-binding transcription factor activity
C2U37_03975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U37_03980	COG4208	sulfate ABC transporter
C2U37_03985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U37_03995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U37_04025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U37_04030	COG0564	pseudouridine synthase activity
C2U37_04050	COG0459	protein refolding
C2U37_04055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U37_04065	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U37_04070	COG1027	Aspartate ammonia-lyase
C2U37_04075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U37_04080	COG2918	glutathione biosynthetic process
C2U37_04085	COG0612	Peptidase, M16
C2U37_04090	COG1238	metal cluster binding
C2U37_04130	COG0359	binds to the 23S rRNA
C2U37_04135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U37_04140	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U37_04145	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U37_04155	COG2153	protein acetylation
C2U37_04165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U37_04170	COG0557	exoribonuclease II activity
C2U37_04175	COG3706	GGDEF domain
C2U37_04180	COG1854	S-ribosylhomocysteine lyase activity
C2U37_04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_04195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U37_04230	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U37_04235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U37_04240	COG1047	Peptidyl-prolyl cis-trans
C2U37_04245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U37_04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U37_04255	COG0196	riboflavin kinase activity
C2U37_04260	COG0728	peptidoglycan biosynthetic process
C2U37_04265	COG0268	Binds directly to 16S ribosomal RNA
C2U37_04270	COG0640	Transcriptional regulator
C2U37_04275	COG0583	DNA-binding transcription factor activity
C2U37_04285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U37_04290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U37_04295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U37_04305	COG1051	belongs to the nudix hydrolase family
C2U37_04320	COG0335	large ribosomal subunit rRNA binding
C2U37_04325	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U37_04330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U37_04335	COG0228	four-way junction DNA binding
C2U37_04340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U37_04345	COG4137	Cytochrome C assembly protein
C2U37_04350	COG4536	flavin adenine dinucleotide binding
C2U37_04360	COG1017	nitric oxide dioxygenase activity
C2U37_04360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U37_04365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U37_04375	COG0039	L-malate dehydrogenase activity
C2U37_04380	COG4160	amino acid transport
C2U37_04385	COG4215	(ABC) transporter
C2U37_04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_04395	COG1126	abc transporter atp-binding protein
C2U37_04400	COG1438	arginine binding
C2U37_04405	COG2837	iron assimilation
C2U37_04410	COG3842	ATPase activity
C2U37_04425	COG0347	Belongs to the P(II) protein family
C2U37_04440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_04445	COG0583	DNA-binding transcription factor activity
C2U37_04460	COG1929	Belongs to the glycerate kinase type-1 family
C2U37_04465	COG2610	gluconate transmembrane transporter activity
C2U37_04470	COG3835	regulator
C2U37_04475	COG3112	Uncharacterised protein family (UPF0231)
C2U37_04495	COG1872	DUF167
C2U37_04500	COG0762	integral membrane protein
C2U37_04505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U37_04510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U37_04520	COG2805	Type II/IV secretion system protein
C2U37_04525	COG3022	response to hydroperoxide
C2U37_04530	COG0513	Belongs to the DEAD box helicase family
C2U37_04535	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U37_04555	COG0735	belongs to the Fur family
C2U37_04560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U37_04575	COG0776	regulation of translation
C2U37_04580	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U37_04590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U37_04605	COG0560	Phosphoserine phosphatase
C2U37_04615	COG3447	MASE1 domain protein
C2U37_04615	COG5001	Diguanylate cyclase
C2U37_04615	COG5002	protein histidine kinase activity
C2U37_04620	COG0813	purine-nucleoside phosphorylase activity
C2U37_04625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U37_04630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U37_04635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U37_04645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_04650	COG0084	hydrolase, TatD family'
C2U37_04665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_04670	COG0004	ammonium transporteR
C2U37_04690	COG0795	lipopolysaccharide-transporting ATPase activity
C2U37_04695	COG0795	lipopolysaccharide-transporting ATPase activity
C2U37_04700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_04705	COG2927	DNA polymerase III (CHI subunit)
C2U37_04710	COG0525	valine-tRNA ligase activity
C2U37_04715	COG1253	flavin adenine dinucleotide binding
C2U37_04720	COG0586	Pfam SNARE associated Golgi protein
C2U37_04725	COG1686	Belongs to the peptidase S11 family
C2U37_04760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U37_04765	COG0527	aspartate kinase activity
C2U37_04770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U37_04775	COG2137	regulation of response to DNA damage stimulus
C2U37_04780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U37_04785	COG1546	Belongs to the CinA family
C2U37_04795	COG4584	PFAM Integrase catalytic
C2U37_04800	COG1484	DNA-dependent DNA replication
C2U37_04825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_04850	COG0732	type I restriction modification DNA specificity domain
C2U37_04855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U37_04890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U37_04920	COG0739	heme binding
C2U37_04940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U37_04945	COG1121	(ABC) transporter
C2U37_04950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U37_04955	COG0583	DNA-binding transcription factor activity
C2U37_04965	COG1573	uracil-dna glycosylase
C2U37_04970	COG2962	Rard protein
C2U37_04975	COG2827	Endonuclease containing a URI domain
C2U37_04990	COG1842	Phage shock protein A
C2U37_04995	COG0204	Acyl-transferase
C2U37_05015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_05025	COG0484	heat shock protein binding
C2U37_05070	COG3039	Transposase
C2U37_05085	COG0187	DNA topoisomerase II activity
C2U37_05090	COG1289	transmembrane transporter activity
C2U37_05095	COG1566	PFAM secretion protein HlyD family protein
C2U37_05110	COG1051	belongs to the nudix hydrolase family
C2U37_05115	COG3150	esterase
C2U37_05130	COG3151	Protein conserved in bacteria
C2U37_05135	COG0494	nUDIX hydrolase
C2U37_05140	COG1538	Outer membrane efflux protein
C2U37_05145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U37_05145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U37_05150	COG1560	Kdo2-lipid A biosynthetic process
C2U37_05165	COG2771	luxR family
C2U37_05170	COG3916	Acyl-homoserine-lactone synthase
C2U37_05180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U37_05185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_05185	COG2213	PTS system mannitol-specific
C2U37_05190	COG0246	Mannitol dehydrogenase
C2U37_05195	COG3722	fumarate hydratase activity
C2U37_05220	COG1671	Belongs to the UPF0178 family
C2U37_05235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_05240	COG0513	Belongs to the DEAD box helicase family
C2U37_05260	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U37_05265	COG1169	isochorismate synthase
C2U37_05270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U37_05275	COG0596	Alpha beta hydrolase
C2U37_05280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U37_05290	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_05295	COG3291	Pkd domain containing protein
C2U37_05300	COG2949	membrane
C2U37_05315	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U37_05345	COG2873	o-acetylhomoserine
C2U37_05355	COG1979	alcohol dehydrogenase
C2U37_05370	COG4221	oxidoreductase activity
C2U37_05390	COG1285	pathogenesis
C2U37_05405	COG1368	sulfuric ester hydrolase activity
C2U37_05410	COG1522	sequence-specific DNA binding
C2U37_05420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U37_05430	COG1058	Belongs to the CinA family
C2U37_05430	COG1546	Belongs to the CinA family
C2U37_05435	COG1988	membrane-bound metal-dependent
C2U37_05445	COG0561	phosphatase activity
C2U37_05450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U37_05460	COG1011	Hydrolase
C2U37_05475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U37_05480	COG0019	diaminopimelate decarboxylase activity
C2U37_05490	COG1965	Belongs to the frataxin family
C2U37_05495	COG0400	carboxylic ester hydrolase activity
C2U37_05500	COG3072	Adenylate cyclase
C2U37_05510	COG0181	hydroxymethylbilane synthase activity
C2U37_05520	COG2959	enzyme of heme biosynthesis
C2U37_05525	COG3071	HemY protein
C2U37_05535	COG1494	fructose-1,6-bisphosphatase
C2U37_05545	COG2226	methyltransferase
C2U37_05570	COG1733	regulation of RNA biosynthetic process
C2U37_05585	COG3932	Exopolysaccharide synthesis, ExoD
C2U37_05590	COG2199	diguanylate cyclase activity
C2U37_05590	COG2203	Gaf domain
C2U37_05620	COG3039	Transposase
C2U37_05630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U37_05635	COG2022	thiamine diphosphate biosynthetic process
C2U37_05645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U37_05650	COG0352	thiamine-phosphate diphosphorylase activity
C2U37_05655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U37_05670	COG0745	RESPONSE REGULATOR receiver
C2U37_05680	COG0189	ligase activity
C2U37_05715	COG2321	neutral zinc metallopeptidase
C2U37_05725	COG0477	Major facilitator Superfamily
C2U37_05740	COG0312	modulator of DNA gyrase
C2U37_05745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_05750	COG3164	Protein of unknown function
C2U37_05755	COG1530	ribonuclease E activity
C2U37_05760	COG0424	maF-like protein
C2U37_05765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U37_05770	COG1792	Involved in formation and maintenance of cell shape
C2U37_05775	COG1077	Cell shape determining protein MreB Mrl
C2U37_05820	COG1459	type II secretion system
C2U37_05885	COG0387	Pfam Sodium calcium exchanger
C2U37_05890	COG2986	histidine ammonia-lyase
C2U37_05895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U37_05900	COG0010	Belongs to the arginase family
C2U37_05905	COG1228	amidohydrolase
C2U37_05910	COG2188	Transcriptional regulator
C2U37_05915	COG0288	reversible hydration of carbon dioxide
C2U37_05925	COG2177	Part of the ABC transporter FtsEX involved in
C2U37_05930	COG2884	Cell division ATP-binding protein ftsE
C2U37_05935	COG0552	protein localization to endoplasmic reticulum
C2U37_05940	COG0742	ribosomal rna small subunit methyltransferase
C2U37_05965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U37_05970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U37_05980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_05990	COG2095	MarC family integral membrane protein
C2U37_06000	COG1301	dicarboxylic acid transport
C2U37_06010	COG0583	DNA-binding transcription factor activity
C2U37_06025	COG3714	YhhN family
C2U37_06045	COG1770	oligopeptidase
C2U37_06060	COG4221	oxidoreductase activity
C2U37_06070	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U37_06130	COG0203	ribosomal protein L17
C2U37_06135	COG0202	RNA polymerase activity
C2U37_06140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U37_06145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U37_06150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U37_06155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U37_06160	COG0201	protein transport
C2U37_06165	COG0200	Binds to the 23S rRNA
C2U37_06170	COG1841	ribosomal large subunit assembly
C2U37_06175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U37_06180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U37_06185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U37_06190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U37_06195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U37_06200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U37_06205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U37_06210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U37_06215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U37_06220	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U37_06225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U37_06230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U37_06235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U37_06240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U37_06245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U37_06250	COG0089	rRNA binding
C2U37_06255	COG0088	Forms part of the polypeptide exit tunnel
C2U37_06260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U37_06265	COG0051	transcription antitermination factor activity, RNA binding
C2U37_06275	COG2205	protein histidine kinase activity
C2U37_06280	COG0745	RESPONSE REGULATOR receiver
C2U37_06285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U37_06290	COG2183	response to ionizing radiation
C2U37_06305	COG0596	Alpha beta hydrolase
C2U37_06310	COG1040	competence protein
C2U37_06315	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U37_06315	COG0316	Belongs to the HesB IscA family
C2U37_06320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U37_06325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U37_06330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_06335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U37_06340	COG4942	peptidase
C2U37_06350	COG1609	Transcriptional regulator
C2U37_06365	COG0800	Aldolase
C2U37_06370	COG0129	dihydroxy-acid dehydratase activity
C2U37_06375	COG3265	gluconokinase activity
C2U37_06380	COG2610	gluconate transmembrane transporter activity
C2U37_06385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U37_06390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U37_06400	COG0456	acetyltransferase
C2U37_06410	COG1490	D-aminoacyl-tRNA deacylase activity
C2U37_06415	COG1295	ribonuclease BN
C2U37_06425	COG0174	glutamine synthetase
C2U37_06435	COG3852	Histidine kinase
C2U37_06445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U37_06450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U37_06460	COG3078	GTPase activator activity
C2U37_06470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U37_06480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U37_06485	COG0408	coproporphyrinogen oxidase activity
C2U37_06490	COG0009	L-threonylcarbamoyladenylate synthase
C2U37_06495	COG0551	DNA topoisomerase type I activity
C2U37_06500	COG2922	Belongs to the Smg family
C2U37_06505	COG0758	DNA mediated transformation
C2U37_06515	COG0242	peptide deformylase activity
C2U37_06520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U37_06525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_06525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_06530	COG0569	domain protein
C2U37_06535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_06540	COG1322	Protein conserved in bacteria
C2U37_06570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_06580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U37_06580	COG0519	Catalyzes the synthesis of GMP from XMP
C2U37_06595	COG1396	sequence-specific DNA binding
C2U37_06600	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_06605	COG2962	Rard protein
C2U37_06615	COG1280	lysine exporter protein (LysE YggA)
C2U37_06655	COG0583	DNA-binding transcription factor activity
C2U37_06660	COG1943	Transposase
C2U37_06665	COG0210	DNA helicase
C2U37_06695	COG0583	DNA-binding transcription factor activity
C2U37_06720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U37_06725	COG0385	Bile acid
C2U37_06730	COG0531	amino acid
C2U37_06735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_06740	COG0531	amino acid
C2U37_06745	COG2731	YhcH YjgK YiaL family protein
C2U37_06750	COG3250	beta-galactosidase activity
C2U37_06755	COG1609	Transcriptional regulator
C2U37_06795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U37_06800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_06800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_06805	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U37_06810	COG3074	FtsZ-dependent cytokinesis
C2U37_06820	COG1045	serine acetyltransferase
C2U37_06830	COG0745	RESPONSE REGULATOR receiver
C2U37_06835	COG2205	protein histidine kinase activity
C2U37_06840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U37_06845	COG0534	Mate efflux family protein
C2U37_06860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_06865	COG2937	Belongs to the GPAT DAPAT family
C2U37_06870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U37_06875	COG3161	chorismate lyase activity
C2U37_06880	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U37_06900	COG1609	Transcriptional regulator
C2U37_06925	COG0859	PFAM glycosyl transferase family 9
C2U37_06930	COG3306	glycosyltransferase involved in LPS biosynthesis
C2U37_06945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U37_06955	COG0156	8-amino-7-oxononanoate synthase activity
C2U37_06960	COG1063	alcohol dehydrogenase
C2U37_06980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U37_06985	COG2166	iron-sulfur cluster assembly
C2U37_06990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U37_07040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U37_07045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U37_07050	COG2223	nitrite transmembrane transporter activity
C2U37_07055	COG3279	Response regulator of the LytR AlgR family
C2U37_07060	COG3275	phosphorelay sensor kinase activity
C2U37_07080	COG3039	Transposase
C2U37_07100	COG1280	lysine exporter protein (LysE YggA)
C2U37_07105	COG2223	nitrite transmembrane transporter activity
C2U37_07110	COG2081	HI0933 family
C2U37_07115	COG1528	Iron-storage protein
C2U37_07120	COG3706	GGDEF domain
C2U37_07125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U37_07135	COG0589	response to stress
C2U37_07175	COG3642	lipopolysaccharide core region biosynthetic process
C2U37_07180	COG0859	PFAM glycosyl transferase family 9
C2U37_07200	COG1758	RNA polymerase activity
C2U37_07205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U37_07210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U37_07215	COG2267	carboxylic ester hydrolase activity
C2U37_07220	COG0561	phosphatase activity
C2U37_07250	COG1309	transcriptional regulator
C2U37_07255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_07260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_07265	COG4191	Histidine kinase
C2U37_07265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_07270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U37_07295	COG2205	protein histidine kinase activity
C2U37_07300	COG0745	RESPONSE REGULATOR receiver
C2U37_07305	COG2814	Major facilitator Superfamily
C2U37_07320	COG3977	Valine--pyruvate aminotransferase
C2U37_07325	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U37_07330	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U37_07335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_07340	COG2207	Transcriptional regulator
C2U37_07345	COG0187	DNA topoisomerase II activity
C2U37_07355	COG0592	DNA-directed DNA polymerase activity
C2U37_07360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U37_07380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U37_07385	COG0594	ribonuclease P activity
C2U37_07390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U37_07395	COG0706	membrane insertase activity
C2U37_07400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U37_07410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U37_07415	COG1120	ATPase activity
C2U37_07420	COG4615	Cyclic peptide transporter
C2U37_07425	COG4774	siderophore transport
C2U37_07430	COG0716	FMN binding
C2U37_07435	COG0445	tRNA wobble uridine modification
C2U37_07440	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U37_07445	COG1192	Involved in chromosome partitioning
C2U37_07450	COG1475	DNA binding
C2U37_07460	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U37_07470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U37_07475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U37_07480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U37_07485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U37_07490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U37_07495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U37_07500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U37_07505	COG4452	Inner membrane protein CreD
C2U37_07515	COG2205	protein histidine kinase activity
C2U37_07520	COG0745	RESPONSE REGULATOR receiver
C2U37_07525	COG1349	DNA-binding transcription factor activity
C2U37_07530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U37_07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_07610	COG0166	Belongs to the GPI family
C2U37_07640	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_07650	COG1349	DNA-binding transcription factor activity
C2U37_07665	COG2771	luxR family
C2U37_07675	COG0811	peptide transport
C2U37_07680	COG0811	peptide transport
C2U37_07685	COG0848	biopolymer transport protein
C2U37_07690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U37_07725	COG0402	S-adenosylhomocysteine deaminase activity
C2U37_07730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U37_07740	COG3165	ubiquinone biosynthetic process from chorismate
C2U37_07745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U37_07750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_07755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_07760	COG0805	protein transport
C2U37_07765	COG0084	hydrolase, TatD family'
C2U37_07775	COG0339	signal peptide processing
C2U37_07785	COG0742	ribosomal rna small subunit methyltransferase
C2U37_07795	COG0248	Ppx GppA phosphatase
C2U37_07800	COG0513	Belongs to the DEAD box helicase family
C2U37_07805	COG3118	belongs to the thioredoxin family
C2U37_07810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U37_07820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U37_07830	COG2960	long-chain fatty acid transporting porin activity
C2U37_07845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_07875	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U37_07885	COG1609	Transcriptional regulator
C2U37_07890	COG3604	Transcriptional regulator
C2U37_07895	COG1773	rubredoxin
C2U37_07895	COG0426	domain, Protein
C2U37_07900	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_07910	COG0348	domain, Protein
C2U37_07925	COG0814	amino acid
C2U37_07930	COG0814	amino acid
C2U37_07950	COG3706	GGDEF domain
C2U37_07950	COG4251	negative regulation of phosphorylation
C2U37_07950	COG2203	Gaf domain
C2U37_07950	COG5001	Diguanylate cyclase
C2U37_07955	COG3039	Transposase
C2U37_07960	COG0751	glycine-tRNA ligase activity
C2U37_07965	COG0752	glycyl-tRNA synthetase alpha subunit
C2U37_07970	COG2818	Glycosylase
C2U37_07975	COG1335	isochorismatase
C2U37_07985	COG2885	chlorophyll binding
C2U37_08010	COG0251	oxidation-reduction process
C2U37_08015	COG0425	Belongs to the sulfur carrier protein TusA family
C2U37_08030	COG2205	protein histidine kinase activity
C2U37_08035	COG0745	RESPONSE REGULATOR receiver
C2U37_08040	COG0183	Belongs to the thiolase family
C2U37_08045	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U37_08045	COG1024	Enoyl-CoA hydratase
C2U37_08050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U37_08055	COG0006	proline dipeptidase activity
C2U37_08060	COG1739	Uncharacterized protein family UPF0029
C2U37_08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_08070	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U37_08095	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U37_08095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_08095	COG1042	CoA-binding domain protein
C2U37_08105	COG0583	DNA-binding transcription factor activity
C2U37_08110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U37_08115	COG0166	Belongs to the GPI family
C2U37_08125	COG0668	transmembrane transport
C2U37_08135	COG1309	transcriptional regulator
C2U37_08140	COG0756	dUTP diphosphatase activity
C2U37_08145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U37_08150	COG2003	Belongs to the UPF0758 family
C2U37_08155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U37_08160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U37_08170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U37_08175	COG2990	Protein conserved in bacteria
C2U37_08180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U37_08185	COG0859	PFAM glycosyl transferase family 9
C2U37_08190	COG0463	Glycosyl transferase, family 2
C2U37_08195	COG0859	PFAM glycosyl transferase family 9
C2U37_08200	COG1519	Transferase
C2U37_08210	COG1561	YicC-like family, N-terminal region
C2U37_08215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U37_08220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U37_08235	COG2203	Gaf domain
C2U37_08235	COG4251	negative regulation of phosphorylation
C2U37_08235	COG5001	Diguanylate cyclase
C2U37_08235	COG3706	GGDEF domain
C2U37_08240	COG3084	Protein conserved in bacteria
C2U37_08250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U37_08255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U37_08260	COG3639	organic phosphonate transmembrane transporter activity
C2U37_08265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U37_08270	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2U37_08280	COG1335	isochorismatase
C2U37_08290	COG1683	Conserved Protein
C2U37_08295	COG0204	Acyl-transferase
C2U37_08300	COG0204	Acyl-transferase
C2U37_08305	COG0606	chelatase, subunit chli
C2U37_08320	COG3978	acetolactate synthase activity
C2U37_08325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U37_08330	COG0129	dihydroxy-acid dehydratase activity
C2U37_08350	COG1309	transcriptional regulator
C2U37_08355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U37_08360	COG0254	rRNA binding
C2U37_08365	COG0702	epimerase
C2U37_08370	COG0281	malic enzyme
C2U37_08380	COG2205	protein histidine kinase activity
C2U37_08390	COG0745	RESPONSE REGULATOR receiver
C2U37_08395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_08410	COG0366	Alpha amylase catalytic
C2U37_08425	COG0443	Heat shock 70 kDa protein
C2U37_08430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U37_08435	COG3045	CreA protein
C2U37_08450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U37_08455	COG0174	glutamine synthetase
C2U37_08475	COG3842	ATPase activity
C2U37_08480	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U37_08485	COG1177	transmembrane transport
C2U37_08490	COG2258	MOSC domain
C2U37_08505	COG2050	protein possibly involved in aromatic compounds catabolism
C2U37_08510	COG0514	ATP-dependent DNA helicase (RecQ)
C2U37_08520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U37_08530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U37_08535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U37_08540	COG2239	Acts as a magnesium transporter
C2U37_08545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_08545	COG1648	precorrin-2 dehydrogenase activity
C2U37_08550	COG2116	formate transmembrane transporter activity
C2U37_08555	COG2146	nitrite reductase [NAD(P)H] activity
C2U37_08560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_08565	COG0842	Transport permease protein
C2U37_08570	COG0842	Transport permease protein
C2U37_08575	COG1131	(ABC) transporter
C2U37_08580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_08595	COG0477	Major facilitator Superfamily
C2U37_08600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U37_08605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U37_08625	COG1595	DNA-templated transcription, initiation
C2U37_08630	COG3806	Anti-sigma factor
C2U37_08635	COG1968	undecaprenyl-diphosphatase activity
C2U37_08640	COG0667	Aldo Keto reductase
C2U37_08645	COG2017	converts alpha-aldose to the beta-anomer
C2U37_08650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U37_08660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U37_08665	COG1609	Transcriptional regulator
C2U37_08670	COG3250	beta-galactosidase activity
C2U37_08710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U37_08715	COG1288	antiporter activity
C2U37_08720	COG1438	arginine binding
C2U37_08725	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U37_08730	COG0540	Belongs to the ATCase OTCase family
C2U37_08755	COG0840	transmembrane signaling receptor activity
C2U37_08765	COG3040	lipid binding
C2U37_08770	COG2207	Transcriptional regulator
C2U37_08775	COG1979	alcohol dehydrogenase
C2U37_08780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U37_08785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U37_08790	COG3385	transposase activity
C2U37_08795	COG2964	Protein conserved in bacteria
C2U37_08800	COG3681	Belongs to the UPF0597 family
C2U37_08805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_08810	COG0564	pseudouridine synthase activity
C2U37_08820	COG0542	response to heat
C2U37_08825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_08830	COG2502	aspartate--ammonia ligase
C2U37_08835	COG1522	sequence-specific DNA binding
C2U37_08845	COG0517	IMP dehydrogenase activity
C2U37_08845	COG0516	GMP reductase activity
C2U37_08865	COG2205	protein histidine kinase activity
C2U37_08875	COG2204	response regulator
C2U37_08895	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U37_08915	COG0745	RESPONSE REGULATOR receiver
C2U37_08920	COG2205	protein histidine kinase activity
C2U37_08930	COG0243	molybdopterin cofactor binding
C2U37_08935	COG3005	denitrification pathway
C2U37_08940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U37_08945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_08950	COG0569	domain protein
C2U37_08955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U37_08980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U37_08990	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U37_08995	COG0250	Participates in transcription elongation, termination and antitermination
C2U37_09000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U37_09005	COG0081	regulation of translation
C2U37_09010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U37_09015	COG0222	ribosome binding
C2U37_09020	COG0085	RNA polymerase activity
C2U37_09025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U37_09030	COG2964	Protein conserved in bacteria
C2U37_09035	COG0251	oxidation-reduction process
C2U37_09040	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U37_09050	COG2168	tRNA wobble position uridine thiolation
C2U37_09055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U37_09060	COG0049	tRNA binding
C2U37_09065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U37_09070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U37_09075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U37_09105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U37_09110	COG2252	PERMEase
C2U37_09115	COG2376	Dihydroxyacetone kinase
C2U37_09120	COG1461	Dihydroxyacetone kinase
C2U37_09150	COG0628	permease
C2U37_09155	COG0494	nUDIX hydrolase
C2U37_09175	COG0753	catalase activity
C2U37_09180	COG0456	acetyltransferase
C2U37_09200	COG3706	GGDEF domain
C2U37_09200	COG0745	RESPONSE REGULATOR receiver
C2U37_09210	COG3842	ATPase activity
C2U37_09220	COG1175	transmembrane transport
C2U37_09245	COG0583	DNA-binding transcription factor activity
C2U37_09255	COG1741	Belongs to the pirin family
C2U37_09260	COG2259	Doxx family
C2U37_09265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U37_09270	COG1074	ATP-dependent DNA helicase activity
C2U37_09275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U37_09285	COG3039	Transposase
C2U37_09290	COG0004	ammonium transporteR
C2U37_09295	COG0347	Belongs to the P(II) protein family
C2U37_09300	COG3706	GGDEF domain
C2U37_09320	COG0745	RESPONSE REGULATOR receiver
C2U37_09325	COG2205	protein histidine kinase activity
C2U37_09330	COG1278	Cold shock
C2U37_09335	COG2801	Transposase and inactivated derivatives
C2U37_09360	COG2197	response regulator
C2U37_09365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U37_09410	COG3135	benzoate transporter
C2U37_09415	COG1396	sequence-specific DNA binding
C2U37_09445	COG2926	Belongs to the UPF0265 family
C2U37_09455	COG3028	Belongs to the UPF0307 family
C2U37_09460	COG0312	modulator of DNA gyrase
C2U37_09465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U37_09470	COG5007	Belongs to the BolA IbaG family
C2U37_09480	COG2854	intermembrane phospholipid transfer
C2U37_09485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U37_09490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U37_09495	COG1127	ABC transporter
C2U37_09500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U37_09500	COG0517	IMP dehydrogenase activity
C2U37_09505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U37_09515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U37_09520	COG1137	ATPase activity
C2U37_09525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U37_09535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_09540	COG1660	Displays ATPase and GTPase activities
C2U37_09545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_09565	COG3964	amidohydrolase
C2U37_09595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U37_09600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U37_09610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U37_09615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U37_09620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U37_09625	COG0723	plastoquinol--plastocyanin reductase activity
C2U37_09630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U37_09635	COG2857	Cytochrome c1
C2U37_09640	COG0625	glutathione transferase activity
C2U37_09645	COG2969	positive regulation of protein catabolic process
C2U37_09650	COG2823	Periplasmic or secreted lipoprotein
C2U37_09655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U37_09660	COG0792	nuclease activity
C2U37_09665	COG3107	peptidoglycan biosynthetic process
C2U37_09670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U37_09695	COG1987	bacterial-type flagellum assembly
C2U37_09715	COG2204	response regulator
C2U37_09720	COG1677	Flagellar hook-basal body complex protein FliE
C2U37_09730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U37_09760	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U37_09765	COG1815	bacterial-type flagellum-dependent cell motility
C2U37_09770	COG1558	bacterial-type flagellum-dependent cell motility
C2U37_09775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2U37_09780	COG1749	Flagellar hook protein flgE
C2U37_09790	COG4786	Flagellar basal body rod
C2U37_09795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U37_09800	COG1706	bacterial-type flagellum-dependent cell motility
C2U37_09810	COG1256	bacterial-type flagellum assembly
C2U37_09810	COG4786	Flagellar basal body rod
C2U37_09815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_09835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_09840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_09845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U37_09870	COG1191	sigma factor activity
C2U37_09875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_09880	COG1360	Flagellar Motor Protein
C2U37_09890	COG0741	lytic transglycosylase activity
C2U37_09890	COG1388	LysM domain
C2U37_09900	COG2001	Belongs to the MraZ family
C2U37_09905	COG0275	rRNA processing
C2U37_09910	COG3116	cell division
C2U37_09915	COG0768	penicillin binding
C2U37_09920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U37_09925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U37_09930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U37_09935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U37_09940	COG0772	Belongs to the SEDS family
C2U37_09945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U37_09950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U37_09955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U37_09960	COG0849	cell division
C2U37_09965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U37_09970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U37_09980	COG0653	protein targeting
C2U37_09990	COG0494	nUDIX hydrolase
C2U37_09995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U37_10000	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U37_10010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2U37_10015	COG1459	type II secretion system
C2U37_10020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U37_10045	COG2186	Transcriptional regulator
C2U37_10050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U37_10055	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U37_10060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U37_10070	COG0840	transmembrane signaling receptor activity
C2U37_10075	COG0840	transmembrane signaling receptor activity
C2U37_10085	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U37_10090	COG2200	EAL domain
C2U37_10100	COG1280	lysine exporter protein (LysE YggA)
C2U37_10110	COG0523	cobalamin synthesis protein
C2U37_10115	COG0477	Major facilitator Superfamily
C2U37_10130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U37_10135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U37_10180	COG5006	permease, DMT superfamily
C2U37_10185	COG1522	sequence-specific DNA binding
C2U37_10190	COG0110	maltose O-acetyltransferase activity
C2U37_10195	COG0366	Alpha amylase catalytic
C2U37_10200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_10200	COG1263	PTS System
C2U37_10220	COG0252	asparaginase activity
C2U37_10235	COG1803	Methylglyoxal synthase
C2U37_10255	COG1444	tRNA N-acetyltransferase activity
C2U37_10260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U37_10270	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U37_10300	COG0109	protoheme IX farnesyltransferase activity
C2U37_10305	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_10310	COG1177	transmembrane transport
C2U37_10315	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U37_10320	COG3842	ATPase activity
C2U37_10325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U37_10330	COG0583	DNA-binding transcription factor activity
C2U37_10335	COG1757	Na H antiporter
C2U37_10375	COG0297	glycogen (starch) synthase activity
C2U37_10380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U37_10385	COG2813	Specifically methylates the guanine in position
C2U37_10390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U37_10395	COG4251	negative regulation of phosphorylation
C2U37_10395	COG2203	Gaf domain
C2U37_10395	COG5001	Diguanylate cyclase
C2U37_10395	COG3706	GGDEF domain
C2U37_10400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_10410	COG2995	paraquat-inducible protein a
C2U37_10415	COG3008	intermembrane lipid transfer
C2U37_10415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U37_10420	COG3009	Protein conserved in bacteria
C2U37_10430	COG3240	lipase activity
C2U37_10445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U37_10450	COG1194	a g-specific adenine glycosylase
C2U37_10460	COG3409	Peptidoglycan-binding domain 1 protein
C2U37_10460	COG3267	Type II secretory pathway component ExeA
C2U37_10465	COG0617	tRNA 3'-terminal CCA addition
C2U37_10470	COG0306	phosphate transporter
C2U37_10475	COG1392	Phosphate transport regulator
C2U37_10480	COG3025	triphosphatase activity
C2U37_10485	COG3133	Outer membrane lipoprotein
C2U37_10490	COG0456	acetyltransferase
C2U37_10505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U37_10510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U37_10520	COG3031	protein transport across the cell outer membrane
C2U37_10530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U37_10535	COG1459	type II secretion system
C2U37_10540	COG2165	general secretion pathway protein
C2U37_10550	COG2165	general secretion pathway protein
C2U37_10555	COG4795	General secretion pathway protein
C2U37_10565	COG3156	type II secretion system protein K
C2U37_10575	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U37_10590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U37_10605	COG1011	Hydrolase
C2U37_10610	COG0494	nUDIX hydrolase
C2U37_10615	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U37_10620	COG0814	amino acid
C2U37_10625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_10640	COG0626	cystathionine gamma-synthase activity
C2U37_10645	COG0460	homoserine dehydrogenase
C2U37_10645	COG0527	aspartate kinase activity
C2U37_10650	COG1346	cytolysis
C2U37_10655	COG1380	Effector of murein hydrolase LrgA
C2U37_10660	COG0583	DNA-binding transcription factor activity
C2U37_10695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U37_10705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U37_10715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U37_10720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U37_10730	COG0137	argininosuccinate synthase activity
C2U37_10735	COG0165	Argininosuccinate lyase
C2U37_10740	COG0583	DNA-binding transcription factor activity
C2U37_10750	COG1942	4-Oxalocrotonate Tautomerase
C2U37_10780	COG0110	maltose O-acetyltransferase activity
C2U37_10785	COG3174	membrane
C2U37_10790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_10795	COG1126	abc transporter atp-binding protein
C2U37_10800	COG0765	amino acid transport
C2U37_10805	COG0765	amino acid transport
C2U37_10810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U37_10815	COG1505	serine-type exopeptidase activity
C2U37_10825	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_10830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U37_10845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U37_10850	COG4991	sh3 domain protein
C2U37_10860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U37_10865	COG1940	carbohydrate kinase activity
C2U37_10870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U37_10875	COG0126	phosphoglycerate kinase activity
C2U37_10885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_10920	COG0583	DNA-binding transcription factor activity
C2U37_10930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U37_10940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U37_10945	COG1595	DNA-templated transcription, initiation
C2U37_10950	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U37_10965	COG0481	GTPase activity
C2U37_10970	COG0681	Belongs to the peptidase S26 family
C2U37_10975	COG0571	ribonuclease III activity
C2U37_10985	COG1381	Involved in DNA repair and RecF pathway recombination
C2U37_10990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U37_10995	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U37_11000	COG4807	Protein conserved in bacteria
C2U37_11010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_11015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U37_11020	COG3956	TIGRFAM MazG family protein
C2U37_11025	COG0504	CTP synthase activity
C2U37_11030	COG0148	phosphopyruvate hydratase activity
C2U37_11035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U37_11040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U37_11050	COG0585	pseudouridine synthase activity
C2U37_11055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U37_11060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U37_11065	COG1238	metal cluster binding
C2U37_11070	COG1388	LysM domain
C2U37_11070	COG4942	peptidase
C2U37_11080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U37_11085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U37_11090	COG1610	YqeY-like protein
C2U37_11095	COG0358	DNA primase activity
C2U37_11100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U37_11120	COG3039	Transposase
C2U37_11130	COG0529	Catalyzes the synthesis of activated sulfate
C2U37_11135	COG3273	potassium ion transport
C2U37_11135	COG0471	metal ion transport
C2U37_11140	COG2895	sulfate adenylyltransferase (ATP) activity
C2U37_11145	COG0175	sulfate reduction
C2U37_11150	COG1648	precorrin-2 dehydrogenase activity
C2U37_11150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_11155	COG0330	HflC and HflK could
C2U37_11160	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U37_11170	COG0673	inositol 2-dehydrogenase activity
C2U37_11180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U37_11185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U37_11190	COG3036	rescue of stalled ribosome
C2U37_11205	COG0138	bifunctional purine biosynthesis protein purh
C2U37_11210	COG0151	Belongs to the GarS family
C2U37_11275	COG1136	(ABC) transporter
C2U37_11290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U37_11305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U37_11310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U37_11315	COG0163	prenyltransferase activity
C2U37_11330	COG1131	(ABC) transporter
C2U37_11335	COG0842	Transport permease protein
C2U37_11345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U37_11350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U37_11355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U37_11365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_11370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U37_11375	COG1489	DNA binding
C2U37_11385	COG1643	Atp-dependent helicase
C2U37_11390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U37_11395	COG0346	lactoylglutathione lyase activity
C2U37_11405	COG2076	Multidrug Resistance protein
C2U37_11410	COG0583	DNA-binding transcription factor activity
C2U37_11420	COG0671	phosphoesterase, PA-phosphatase related
C2U37_11435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U37_11440	COG0038	chloride channel
C2U37_11450	COG0316	Belongs to the HesB IscA family
C2U37_11475	COG1280	lysine exporter protein (LysE YggA)
C2U37_11480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U37_11495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_11525	COG0745	RESPONSE REGULATOR receiver
C2U37_11530	COG3104	oligopeptide transport
C2U37_11535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U37_11540	COG1555	photosystem II stabilization
C2U37_11550	COG2350	Protein conserved in bacteria
C2U37_11555	COG2917	probably involved in intracellular septation
C2U37_11560	COG0076	glutamate decarboxylase activity
C2U37_11565	COG1272	protein, Hemolysin III
C2U37_11570	COG0569	domain protein
C2U37_11570	COG2985	domain, Protein
C2U37_11580	COG0477	Major facilitator Superfamily
C2U37_11585	COG0583	DNA-binding transcription factor activity
C2U37_11590	COG3227	Zinc metalloprotease (Elastase)
C2U37_11595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_11600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_11610	COG2731	YhcH YjgK YiaL family protein
C2U37_11620	COG0668	transmembrane transport
C2U37_11630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U37_11640	COG0789	Transcriptional regulator
C2U37_11685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U37_11695	COG0488	(ABC) transporter
C2U37_11700	COG0517	IMP dehydrogenase activity
C2U37_11700	COG0516	GMP reductase activity
C2U37_11710	COG0784	Response regulator, receiver
C2U37_11710	COG0835	chemotaxis
C2U37_11715	COG2755	lipolytic protein G-D-S-L family
C2U37_11720	COG4181	ATPase activity
C2U37_11725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U37_11730	COG1090	epimerase
C2U37_11735	COG2200	EAL domain
C2U37_11740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_11745	COG2234	aminopeptidase activity
C2U37_11750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U37_11755	COG3171	Protein conserved in bacteria
C2U37_11760	COG2066	Belongs to the glutaminase family
C2U37_11765	COG2897	thiosulfate sulfurtransferase activity
C2U37_11770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_11815	COG1132	(ABC) transporter
C2U37_11840	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U37_11845	COG3300	MHYT domain
C2U37_11845	COG5001	Diguanylate cyclase
C2U37_11865	COG4628	conserved protein (DUF2132)
C2U37_11870	COG0688	phosphatidylethanolamine metabolic process
C2U37_11875	COG1162	GTPase activity
C2U37_11880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U37_11915	COG1278	Cold shock
C2U37_11925	COG0840	transmembrane signaling receptor activity
C2U37_11930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_11935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_11985	COG0848	biopolymer transport protein
C2U37_11990	COG0811	peptide transport
C2U37_11995	COG0811	peptide transport
C2U37_12005	COG4206	TonB-dependent receptor
C2U37_12010	COG4174	ABC transporter (Permease)
C2U37_12015	COG4239	(ABC) transporter, permease
C2U37_12025	COG0444	Belongs to the ABC transporter superfamily
C2U37_12030	COG4608	Belongs to the ABC transporter superfamily
C2U37_12040	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U37_12100	COG5301	cellulose 1,4-beta-cellobiosidase activity
C2U37_12190	COG4695	Portal protein
C2U37_12295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U37_12305	COG4974	Belongs to the 'phage' integrase family
C2U37_12310	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U37_12330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U37_12355	COG0243	molybdopterin cofactor binding
C2U37_12360	COG1648	precorrin-2 dehydrogenase activity
C2U37_12360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_12370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U37_12370	COG1116	anion transmembrane transporter activity
C2U37_12375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U37_12380	COG1116	anion transmembrane transporter activity
C2U37_12385	COG2146	nitrite reductase [NAD(P)H] activity
C2U37_12385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_12390	COG2146	nitrite reductase [NAD(P)H] activity
C2U37_12390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_12395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_12400	COG2313	pseudouridylate synthase activity
C2U37_12420	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U37_12430	COG2966	Psort location CytoplasmicMembrane, score
C2U37_12435	COG3610	response to peptide
C2U37_12445	COG4175	Glycine betaine
C2U37_12450	COG4176	ABC-type proline glycine betaine transport system permease component
C2U37_12455	COG2113	Glycine betaine
C2U37_12460	COG0175	sulfate reduction
C2U37_12465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_12470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U37_12475	COG0384	phenazine biosynthesis protein PhzF
C2U37_12480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U37_12495	COG0786	glutamate:sodium symporter activity
C2U37_12500	COG0252	asparaginase activity
C2U37_12505	COG3139	Protein of unknown function (DUF1315)
C2U37_12525	COG0616	signal peptide processing
C2U37_12530	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_12530	COG1902	pentaerythritol trinitrate reductase activity
C2U37_12535	COG0778	Nitroreductase
C2U37_12555	COG2264	protein methyltransferase activity
C2U37_12560	COG0604	alcohol dehydrogenase
C2U37_12565	COG0583	DNA-binding transcription factor activity
C2U37_12570	COG2190	(PTS) system
C2U37_12570	COG1263	PTS System
C2U37_12570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_12575	COG4145	pantothenate transmembrane transporter activity
C2U37_12580	COG3924	membrane
C2U37_12585	COG0439	Biotin carboxylase
C2U37_12590	COG0511	ligase activity, forming carbon-carbon bonds
C2U37_12595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U37_12600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U37_12615	COG3381	protein complex oligomerization
C2U37_12630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U37_12640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U37_12645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U37_12645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U37_12660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U37_12665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_12670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U37_12675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U37_12680	COG4172	Belongs to the ABC transporter superfamily
C2U37_12700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U37_12705	COG0142	geranyltranstransferase activity
C2U37_12710	COG1722	exodeoxyribonuclease VII activity
C2U37_12715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_12720	COG1360	Flagellar Motor Protein
C2U37_12725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U37_12735	COG1534	Rna-binding protein
C2U37_12740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U37_12745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U37_12750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U37_12755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U37_12760	COG0149	triose-phosphate isomerase activity
C2U37_12765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U37_12780	COG0779	Required for maturation of 30S ribosomal subunits
C2U37_12785	COG0195	Participates in both transcription termination and antitermination
C2U37_12790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U37_12795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U37_12800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U37_12805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U37_12810	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U37_12815	COG2211	Major facilitator Superfamily
C2U37_12820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U37_12825	COG1422	Protein of unknown function (DUF1090)
C2U37_12835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U37_12855	COG0312	modulator of DNA gyrase
C2U37_12865	COG0312	modulator of DNA gyrase
C2U37_12870	COG0716	FMN binding
C2U37_12875	COG4974	Belongs to the 'phage' integrase family
C2U37_12880	COG1970	mechanosensitive ion channel activity
C2U37_12890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U37_12895	COG0789	Transcriptional regulator
C2U37_12910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_12920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U37_12925	COG0321	lipoyl(octanoyl) transferase activity
C2U37_12930	COG2921	Belongs to the UPF0250 family
C2U37_12935	COG1686	Belongs to the peptidase S11 family
C2U37_12940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U37_12945	COG2951	lytic endotransglycosylase activity
C2U37_12950	COG0772	Belongs to the SEDS family
C2U37_12955	COG0768	penicillin binding
C2U37_12960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U37_12965	COG0799	negative regulation of ribosome biogenesis
C2U37_12970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U37_12985	COG0495	leucyl-tRNA aminoacylation
C2U37_12990	COG2888	peptidyl-tyrosine sulfation
C2U37_12995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U37_13000	COG4535	Mg2 and Co2 transporter CorC
C2U37_13005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U37_13010	COG1702	phosphate starvation-inducible protein PhoH
C2U37_13015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U37_13020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_13025	COG1335	isochorismatase
C2U37_13030	COG1278	Cold shock
C2U37_13045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_13050	COG2199	diguanylate cyclase activity
C2U37_13060	COG2199	diguanylate cyclase activity
C2U37_13070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U37_13085	COG1464	Belongs to the NlpA lipoprotein family
C2U37_13090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U37_13095	COG2011	ABC-type metal ion transport system permease component
C2U37_13100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U37_13110	COG0516	GMP reductase activity
C2U37_13115	COG4067	protein conserved in archaea
C2U37_13115	COG0189	ligase activity
C2U37_13125	COG0745	RESPONSE REGULATOR receiver
C2U37_13135	COG0300	oxidoreductase activity
C2U37_13155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_13160	COG3214	Protein conserved in bacteria
C2U37_13175	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U37_13180	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U37_13185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U37_13190	COG1053	succinate dehydrogenase
C2U37_13200	COG0584	glycerophosphoryl diester phosphodiesterase
C2U37_13205	COG3264	Mechanosensitive ion channel
C2U37_13205	COG1511	domain protein
C2U37_13215	COG0739	heme binding
C2U37_13230	COG0583	DNA-binding transcription factor activity
C2U37_13245	COG0583	DNA-binding transcription factor activity
C2U37_13250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U37_13280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U37_13285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U37_13295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U37_13300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U37_13305	COG0546	phosphoglycolate phosphatase activity
C2U37_13310	COG0180	Tryptophanyl-tRNA synthetase
C2U37_13325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U37_13335	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_13350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_13375	COG0471	metal ion transport
C2U37_13375	COG0490	domain, Protein
C2U37_13445	COG1196	nuclear chromosome segregation
C2U37_13450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_13480	COG4644	lycopene metabolic process
C2U37_13515	COG0582	viral genome integration into host DNA
C2U37_13550	COG1309	transcriptional regulator
C2U37_13555	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_13570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_13575	COG0783	Belongs to the Dps family
C2U37_13595	COG0183	Belongs to the thiolase family
C2U37_13605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U37_13660	COG0625	glutathione transferase activity
C2U37_13665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_13675	COG0583	DNA-binding transcription factor activity
C2U37_13685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_13715	COG1846	Transcriptional regulator
C2U37_13720	COG0583	DNA-binding transcription factor activity
C2U37_13730	COG2948	multi-organism process
C2U37_13745	COG3846	protein secretion by the type IV secretion system
C2U37_13760	COG3451	type IV secretory pathway VirB4
C2U37_13775	COG4962	Type ii secretion system protein e
C2U37_13795	COG0741	lytic transglycosylase activity
C2U37_13820	COG0840	transmembrane signaling receptor activity
C2U37_13835	COG4644	lycopene metabolic process
C2U37_13895	COG1484	DNA-dependent DNA replication
C2U37_13900	COG4584	PFAM Integrase catalytic
C2U37_14000	COG4974	Belongs to the 'phage' integrase family
C2U37_14015	COG0582	viral genome integration into host DNA
C2U37_14020	COG0012	GTP binding
C2U37_14025	COG0193	aminoacyl-tRNA hydrolase activity
C2U37_14030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U37_14040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U37_14045	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U37_14050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U37_14055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U37_14060	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U37_14070	COG2912	Transglutaminase-like superfamily
C2U37_14075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U37_14080	COG1301	dicarboxylic acid transport
C2U37_14090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U37_14105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U37_14110	COG1115	amino acid carrier protein
C2U37_14130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U37_14135	COG1678	Uncharacterized ACR, COG1678
C2U37_14140	COG0189	ligase activity
C2U37_14145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U37_14155	COG3091	SprT-like family
C2U37_14165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U37_14190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U37_14195	COG0739	heme binding
C2U37_14200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U37_14205	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2U37_14205	COG3408	Glycogen debranching enzyme
C2U37_14215	COG1881	PFAM PEBP family protein
C2U37_14225	COG0583	DNA-binding transcription factor activity
C2U37_14235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U37_14245	COG0583	DNA-binding transcription factor activity
C2U37_14250	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_14255	COG0616	signal peptide processing
C2U37_14260	COG3724	N-succinylarginine dihydrolase activity
C2U37_14265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U37_14275	COG0840	transmembrane signaling receptor activity
C2U37_14285	COG2971	BadF BadG BcrA BcrD
C2U37_14295	COG4608	Belongs to the ABC transporter superfamily
C2U37_14300	COG0444	Belongs to the ABC transporter superfamily
C2U37_14305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_14320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U37_14390	COG1538	Outer membrane efflux protein
C2U37_14395	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_14410	COG0745	RESPONSE REGULATOR receiver
C2U37_14415	COG5002	protein histidine kinase activity
C2U37_14425	COG0789	Transcriptional regulator
C2U37_14465	COG2132	Multicopper oxidase
C2U37_14475	COG3039	Transposase
C2U37_14540	COG0640	Transcriptional regulator
C2U37_14545	COG0798	PFAM Bile acid sodium symporter
C2U37_14550	COG1393	Belongs to the ArsC family
C2U37_14560	COG1677	Flagellar hook-basal body complex protein FliE
C2U37_14570	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U37_14620	COG1987	bacterial-type flagellum assembly
C2U37_14625	COG1684	flagellar biosynthetic protein fliR
C2U37_14635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U37_14645	COG0455	bacterial-type flagellum organization
C2U37_14660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U37_14665	COG0643	Histidine kinase
C2U37_14665	COG2198	Histidine kinase
C2U37_14670	COG2201	protein-glutamate methylesterase activity
C2U37_14675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_14680	COG1360	Flagellar Motor Protein
C2U37_14685	COG1192	Involved in chromosome partitioning
C2U37_14695	COG0835	chemotaxis
C2U37_14710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_14715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_14720	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_14725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U37_14730	COG1138	Cytochrome C-type biogenesis protein
C2U37_14735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_14760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U37_14765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_14765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_14780	COG0259	pyridoxamine-phosphate oxidase activity
C2U37_14810	COG3153	acetyltransferase
C2U37_14825	COG0800	Aldolase
C2U37_14855	COG1484	DNA-dependent DNA replication
C2U37_14860	COG4584	PFAM Integrase catalytic
C2U37_14890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U37_14915	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_14925	COG2801	Transposase and inactivated derivatives
C2U37_14980	COG3039	Transposase
C2U37_14990	COG2801	Transposase and inactivated derivatives
C2U37_15005	COG3039	Transposase
C2U37_15015	COG0582	viral genome integration into host DNA
C2U37_15065	COG1674	ftsk spoiiie
C2U37_15100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_15135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_15145	COG3645	SOS response
C2U37_15145	COG3646	Phage regulatory protein
C2U37_15190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_15355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U37_15360	COG2867	negative regulation of translational initiation
C2U37_15370	COG0702	epimerase
C2U37_15375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_15380	COG1454	alcohol dehydrogenase
C2U37_15445	COG4382	Mu-like prophage protein Gp16
C2U37_15485	COG0640	Transcriptional regulator
C2U37_15495	COG4373	Mu-like prophage FluMu protein gp28
C2U37_15500	COG4383	Mu-like prophage protein gp29
C2U37_15505	COG2369	cell adhesion
C2U37_15515	COG4388	Caudovirus prohead serine protease
C2U37_15520	COG4397	Mu-like prophage major head subunit gpT
C2U37_15605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U37_15615	COG1957	nucleoside hydrolase
C2U37_15640	COG1280	lysine exporter protein (LysE YggA)
C2U37_15650	COG3263	regulation of cellular component size
C2U37_15660	COG1876	peptidase activity
C2U37_15665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U37_15670	COG1393	Belongs to the ArsC family
C2U37_15695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U37_15700	COG0017	Asparaginyl-tRNA synthetase
C2U37_15720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U37_15725	COG0156	8-amino-7-oxononanoate synthase activity
C2U37_15730	COG2226	methyltransferase
C2U37_15730	COG1073	alpha beta
C2U37_15735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U37_15740	COG0501	Belongs to the peptidase M48B family
C2U37_15745	COG0633	Ferredoxin
C2U37_15745	COG0633	Ferredoxin
C2U37_15745	COG3217	Mosc domain protein beta barrel domain protein
C2U37_15745	COG3217	Mosc domain protein beta barrel domain protein
C2U37_15755	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U37_15755	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U37_15755	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U37_15755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U37_15760	COG2841	Protein conserved in bacteria
C2U37_15770	COG0534	Mate efflux family protein
C2U37_15805	COG1309	transcriptional regulator
C2U37_15820	COG0791	NLP P60 protein
C2U37_15825	COG0583	DNA-binding transcription factor activity
C2U37_15845	COG0500	methyltransferase
C2U37_15850	COG4106	trans-aconitate 2-methyltransferase activity
C2U37_15855	COG1801	Protein of unknown function DUF72
C2U37_15865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U37_15870	COG0217	transcriptional regulatory protein
C2U37_15875	COG2194	sulfuric ester hydrolase activity
C2U37_15880	COG1846	Transcriptional regulator
C2U37_15880	COG1940	carbohydrate kinase activity
C2U37_15885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U37_15890	COG0363	glucosamine-6-phosphate deaminase activity
C2U37_15895	COG1263	PTS System
C2U37_15895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_15895	COG2190	(PTS) system
C2U37_15905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_15910	COG0735	belongs to the Fur family
C2U37_15920	COG0716	FMN binding
C2U37_15935	COG0596	Alpha beta hydrolase
C2U37_15940	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U37_15945	COG0033	Phosphoglucomutase
C2U37_15955	COG1846	Transcriptional regulator
C2U37_15960	COG2951	lytic endotransglycosylase activity
C2U37_15965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U37_15970	COG4136	ATPase activity
C2U37_15980	COG4134	Bacterial extracellular solute-binding protein
C2U37_15990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U37_16000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U37_16010	COG0729	surface antigen
C2U37_16015	COG2911	Protein conserved in bacteria
C2U37_16035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U37_16045	COG0741	lytic transglycosylase activity
C2U37_16060	COG1607	acyl-coa hydrolase
C2U37_16070	COG3021	interspecies interaction between organisms
C2U37_16075	COG0741	lytic transglycosylase activity
C2U37_16075	COG1388	LysM domain
C2U37_16080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U37_16085	COG2226	methyltransferase
C2U37_16090	COG0328	RNA-DNA hybrid ribonuclease activity
C2U37_16095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_16110	COG1960	acyl-CoA dehydrogenase activity
C2U37_16115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U37_16120	COG0121	glutamine amidotransferase
C2U37_16130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U37_16140	COG0784	Response regulator, receiver
C2U37_16140	COG2205	protein histidine kinase activity
C2U37_16165	COG2197	response regulator
C2U37_16170	COG3850	Histidine kinase
C2U37_16175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U37_16180	COG0437	4 iron, 4 sulfur cluster binding
C2U37_16190	COG0243	molybdopterin cofactor binding
C2U37_16195	COG0437	4 iron, 4 sulfur cluster binding
C2U37_16200	COG0348	domain, Protein
C2U37_16210	COG3005	denitrification pathway
C2U37_16215	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U37_16220	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U37_16225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U37_16230	COG0314	molybdopterin synthase activity
C2U37_16245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U37_16250	COG2267	carboxylic ester hydrolase activity
C2U37_16265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U37_16275	COG0302	gtp cyclohydrolase
C2U37_16280	COG0840	transmembrane signaling receptor activity
C2U37_16285	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U37_16295	COG0583	DNA-binding transcription factor activity
C2U37_16325	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U37_16335	COG1166	arginine decarboxylase activity
C2U37_16365	COG3039	Transposase
C2U37_16390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U37_16395	COG1187	pseudouridine synthase activity
C2U37_16400	COG2807	transmembrane transport
C2U37_16410	COG0583	DNA-binding transcription factor activity
C2U37_16425	COG1607	acyl-coa hydrolase
C2U37_16430	COG2979	Protein of unknown function (DUF533)
C2U37_16440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_16450	COG1294	oxidase, subunit
C2U37_16460	COG2814	Major facilitator Superfamily
C2U37_16465	COG0656	L-ascorbic acid biosynthetic process
C2U37_16480	COG3039	Transposase
C2U37_16495	COG0583	DNA-binding transcription factor activity
C2U37_16500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U37_16505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U37_16510	COG2271	Major facilitator Superfamily
C2U37_16515	COG1349	DNA-binding transcription factor activity
C2U37_16525	COG0584	glycerophosphoryl diester phosphodiesterase
C2U37_16530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_16535	COG1605	Chorismate mutase
C2U37_16535	COG0287	Prephenate dehydrogenase
C2U37_16545	COG3085	chromosome segregation
C2U37_16550	COG4574	serine-type endopeptidase inhibitor activity
C2U37_16570	COG1770	oligopeptidase
C2U37_16575	COG4771	TonB-dependent receptor
C2U37_16580	COG3083	sulfuric ester hydrolase activity
C2U37_16585	COG3082	Protein of unknown function (DUF1414)
C2U37_16590	COG3081	Nucleoid-associated protein
C2U37_16600	COG1175	transmembrane transport
C2U37_16610	COG3842	ATPase activity
C2U37_16620	COG0596	Alpha beta hydrolase
C2U37_16635	COG0425	Belongs to the sulfur carrier protein TusA family
C2U37_16640	COG4783	chaperone-mediated protein folding
C2U37_16650	COG1393	Belongs to the ArsC family
C2U37_16675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_16680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U37_16685	COG2431	L-lysine efflux transmembrane transporter activity
C2U37_16695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_16700	COG4215	(ABC) transporter
C2U37_16705	COG4160	amino acid transport
C2U37_16715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U37_16725	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_16740	COG1566	PFAM secretion protein HlyD family protein
C2U37_16750	COG0628	permease
C2U37_16755	COG2373	Large extracellular alpha-helical protein
C2U37_16760	COG4953	penicillin-binding protein 1C
C2U37_16770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_16770	COG0301	tRNA thio-modification
C2U37_16785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_16790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_16795	COG1334	flagellar protein FlaG
C2U37_16825	COG2089	acid synthase
C2U37_16840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U37_16845	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2U37_16855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U37_16860	COG1086	Polysaccharide biosynthesis protein
C2U37_16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U37_16875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U37_16895	COG3385	transposase activity
C2U37_16900	COG0346	lactoylglutathione lyase activity
C2U37_16905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U37_16915	COG4659	FMN binding
C2U37_16920	COG4658	electron transport chain
C2U37_16930	COG2878	Part of a membrane complex involved in electron transport
C2U37_16935	COG4657	Part of a membrane complex involved in electron transport
C2U37_16940	COG0675	Transposase, IS605 OrfB family
C2U37_16950	COG0697	spore germination
C2U37_16970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U37_16980	COG0436	Aminotransferase
C2U37_16990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U37_16995	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U37_17000	COG1061	Type III restriction enzyme res subunit
C2U37_17005	COG1566	PFAM secretion protein HlyD family protein
C2U37_17015	COG3264	Mechanosensitive ion channel
C2U37_17015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U37_17020	COG1966	Carbon starvation protein
C2U37_17025	COG3279	Response regulator of the LytR AlgR family
C2U37_17030	COG3275	phosphorelay sensor kinase activity
C2U37_17040	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_17040	COG1454	alcohol dehydrogenase
C2U37_17045	COG2095	MarC family integral membrane protein
C2U37_17055	COG0601	transmembrane transport
C2U37_17060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_17065	COG0444	Belongs to the ABC transporter superfamily
C2U37_17075	COG0861	Integral membrane protein TerC family
C2U37_17080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_17090	COG1301	dicarboxylic acid transport
C2U37_17110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U37_17125	COG0537	adenosine 5'-monophosphoramidase activity
C2U37_17160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_17165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_17180	COG2354	Protein conserved in bacteria
C2U37_17185	COG1164	Oligoendopeptidase f
C2U37_17190	COG1164	Oligoendopeptidase f
C2U37_17200	COG1252	NADH dehydrogenase
C2U37_17205	COG0393	Putative heavy-metal-binding
C2U37_17210	COG1368	sulfuric ester hydrolase activity
C2U37_17220	COG0527	aspartate kinase activity
C2U37_17225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U37_17225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U37_17230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_17255	COG0583	DNA-binding transcription factor activity
C2U37_17260	COG1620	l-lactate permease
C2U37_17265	COG0247	lactate metabolic process
C2U37_17270	COG1139	Iron-sulfur cluster binding protein
C2U37_17295	COG1136	(ABC) transporter
C2U37_17315	COG2814	Major facilitator Superfamily
C2U37_17340	COG0672	)-iron permease
C2U37_17375	COG2308	Evidence 4 Homologs of previously reported genes of
C2U37_17410	COG0659	secondary active sulfate transmembrane transporter activity
C2U37_17430	COG4584	PFAM Integrase catalytic
C2U37_17435	COG1484	DNA-dependent DNA replication
C2U37_17485	COG3706	GGDEF domain
C2U37_17500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_17545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_17550	COG3039	Transposase
C2U37_17555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U37_17565	COG0326	Molecular chaperone. Has ATPase activity
C2U37_17570	COG0563	adenylate kinase activity
C2U37_17575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U37_17580	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U37_17585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_17590	COG0840	transmembrane signaling receptor activity
C2U37_17610	COG5001	Diguanylate cyclase
C2U37_17610	COG3300	MHYT domain
C2U37_17615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U37_17635	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U37_17640	COG3433	isochorismatase activity
C2U37_17640	COG1535	isochorismatase
C2U37_17645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U37_17650	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_17660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U37_17680	COG1120	ATPase activity
C2U37_17685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_17690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_17695	COG4771	TonB-dependent receptor
C2U37_17715	COG0598	Magnesium transport protein CorA
C2U37_17735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U37_17740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U37_17745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_17750	COG0861	Integral membrane protein TerC family
C2U37_17765	COG1022	Amp-dependent synthetase and ligase
C2U37_17770	COG0295	cytidine deaminase activity
C2U37_17775	COG1346	cytolysis
C2U37_17780	COG1380	Effector of murein hydrolase LrgA
C2U37_17785	COG3345	alpha-galactosidase
C2U37_17795	COG2925	Exonuclease
C2U37_17800	COG0582	viral genome integration into host DNA
C2U37_17865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_17905	COG3646	Phage regulatory protein
C2U37_17960	COG4626	Terminase
C2U37_17960	COG1802	Transcriptional regulator
C2U37_18080	COG2801	Transposase and inactivated derivatives
C2U37_18085	COG3039	Transposase
C2U37_18120	COG0542	response to heat
C2U37_18145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U37_18180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U37_18260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_18265	COG0392	lysyltransferase activity
C2U37_18265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2U37_18280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_18285	COG0436	Aminotransferase
C2U37_18290	COG0583	DNA-binding transcription factor activity
C2U37_18295	COG2160	L-arabinose isomerase activity
C2U37_18305	COG1069	ribulokinase activity
C2U37_18310	COG1879	ABC-type sugar transport system periplasmic component
C2U37_18320	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_18330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U37_18335	COG0254	rRNA binding
C2U37_18350	COG1451	nucleotide metabolic process
C2U37_18365	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U37_18375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U37_18375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_18380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U37_18400	COG2009	succinate dehydrogenase
C2U37_18405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U37_18420	COG0567	Dehydrogenase, E1 component
C2U37_18425	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U37_18430	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U37_18435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U37_18455	COG4372	Transposase
C2U37_18460	COG1882	Formate acetyltransferase
C2U37_18465	COG2116	formate transmembrane transporter activity
C2U37_18470	COG1944	ATP diphosphatase activity
C2U37_18480	COG2076	Multidrug Resistance protein
C2U37_18485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U37_18490	COG1278	Cold shock
C2U37_18495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U37_18500	COG0542	response to heat
C2U37_18505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U37_18510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U37_18515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U37_18520	COG3134	Outer membrane lipoprotein
C2U37_18525	COG3706	GGDEF domain
C2U37_18530	COG0492	ferredoxin-NADP+ reductase activity
C2U37_18535	COG0686	Belongs to the AlaDH PNT family
C2U37_18545	COG0531	amino acid
C2U37_18545	COG1674	ftsk spoiiie
C2U37_18550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U37_18555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U37_18565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U37_18570	COG1286	toxin biosynthetic process
C2U37_18575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U37_18580	COG2723	6-phospho-beta-galactosidase activity
C2U37_18585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_18585	COG1263	PTS System
C2U37_18590	COG1609	Transcriptional regulator
C2U37_18600	COG4172	Belongs to the ABC transporter superfamily
C2U37_18610	COG4171	peptide transport system, permease
C2U37_18615	COG4168	peptide transport system, permease
C2U37_18625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U37_18630	COG1842	Phage shock protein A
C2U37_18645	COG3106	COG3106 Predicted ATPase
C2U37_18650	COG3768	UPF0283 membrane protein
C2U37_18660	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U37_18675	COG2199	diguanylate cyclase activity
C2U37_18680	COG2885	chlorophyll binding
C2U37_18720	COG0675	Transposase, IS605 OrfB family
C2U37_18735	COG0517	IMP dehydrogenase activity
C2U37_18735	COG0516	GMP reductase activity
C2U37_18740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U37_18740	COG0519	Catalyzes the synthesis of GMP from XMP
C2U37_18760	COG1846	Transcriptional regulator
C2U37_18780	COG2062	phosphohistidine phosphatase, SixA
C2U37_18790	COG0697	spore germination
C2U37_18800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U37_18805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U37_18815	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U37_18820	COG1136	(ABC) transporter
C2U37_18825	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U37_18830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U37_18845	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U37_18850	COG0740	serine-type endopeptidase activity
C2U37_18855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U37_18860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U37_18865	COG0776	regulation of translation
C2U37_18870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U37_18875	COG0488	(ABC) transporter
C2U37_18880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U37_18885	COG3162	membrane
C2U37_18900	COG1024	Enoyl-CoA hydratase
C2U37_18905	COG1115	amino acid carrier protein
C2U37_18915	COG3228	Belongs to the MtfA family
C2U37_18920	COG1584	GPR1 FUN34 yaaH family protein
C2U37_18945	COG1024	Enoyl-CoA hydratase
C2U37_18950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U37_18955	COG1960	acyl-CoA dehydrogenase activity
C2U37_18965	COG1960	acyl-CoA dehydrogenase activity
C2U37_18970	COG1024	Enoyl-CoA hydratase
C2U37_18975	COG1024	Enoyl-CoA hydratase
C2U37_18985	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_18995	COG0730	response to heat
C2U37_19010	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_19020	COG1129	ABC transporter
C2U37_19025	COG1879	ABC-type sugar transport system periplasmic component
C2U37_19030	COG0583	DNA-binding transcription factor activity
C2U37_19045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U37_19050	COG0243	molybdopterin cofactor binding
C2U37_19060	COG3706	GGDEF domain
C2U37_19060	COG0745	RESPONSE REGULATOR receiver
C2U37_19065	COG0583	DNA-binding transcription factor activity
C2U37_19070	COG2723	6-phospho-beta-galactosidase activity
C2U37_19080	COG0583	DNA-binding transcription factor activity
C2U37_19095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U37_19100	COG0673	inositol 2-dehydrogenase activity
C2U37_19105	COG0583	DNA-binding transcription factor activity
C2U37_19115	COG1560	Kdo2-lipid A biosynthetic process
C2U37_19120	COG1560	Kdo2-lipid A biosynthetic process
C2U37_19135	COG0417	DNA replication proofreading
C2U37_19165	COG0534	Mate efflux family protein
C2U37_19175	COG0307	riboflavin synthase, alpha
C2U37_19190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_19195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U37_19200	COG0697	spore germination
C2U37_19205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U37_19235	COG0675	Transposase, IS605 OrfB family
C2U37_19240	COG2996	Protein conserved in bacteria
C2U37_19260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U37_19270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U37_19275	COG2894	cell division
C2U37_19280	COG0850	regulation of cytokinetic process
C2U37_19285	COG3100	YcgL domain-containing protein
C2U37_19290	COG2951	lytic endotransglycosylase activity
C2U37_19295	COG1760	l-serine dehydratase
C2U37_19305	COG1760	l-serine dehydratase
C2U37_19310	COG3123	guanosine phosphorylase activity
C2U37_19340	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U37_19345	COG2067	long-chain fatty acid transport protein
C2U37_19350	COG2067	long-chain fatty acid transport protein
C2U37_19360	COG1595	DNA-templated transcription, initiation
C2U37_19390	COG0714	Associated with various cellular activities
C2U37_19395	COG0183	Belongs to the thiolase family
C2U37_19400	COG1024	Enoyl-CoA hydratase
C2U37_19400	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U37_19410	COG4681	YaeQ
C2U37_19420	COG3039	Transposase
C2U37_19440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_19455	COG3134	Outer membrane lipoprotein
C2U37_19460	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_19475	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U37_19475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U37_19480	COG0107	imidazoleglycerol-phosphate synthase activity
C2U37_19485	COG2198	Histidine kinase
C2U37_19485	COG2205	protein histidine kinase activity
C2U37_19485	COG0784	Response regulator, receiver
C2U37_19495	COG3437	response regulator, receiver
C2U37_19500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U37_19505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U37_19510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U37_19510	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U37_19515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U37_19520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U37_19525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U37_19535	COG1199	ATP-dependent helicase activity
C2U37_19540	COG1214	PFAM Peptidase M22, glycoprotease
C2U37_19550	COG0596	Alpha beta hydrolase
C2U37_19555	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_19570	COG0697	spore germination
C2U37_19580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U37_19585	COG2832	Protein of unknown function (DUF454)
C2U37_19590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U37_19600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U37_19605	COG0583	DNA-binding transcription factor activity
C2U37_19620	COG2197	response regulator
C2U37_19630	COG1643	Atp-dependent helicase
C2U37_19640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U37_19655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U37_19660	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U37_19665	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U37_19680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U37_19685	COG0840	transmembrane signaling receptor activity
C2U37_19690	COG1254	Belongs to the acylphosphatase family
C2U37_19700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_19700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_19705	COG0489	protein tyrosine kinase activity
C2U37_19710	COG0572	uridine kinase
C2U37_19715	COG0717	Belongs to the dCTP deaminase family
C2U37_19720	COG0306	phosphate transporter
C2U37_19725	COG4644	lycopene metabolic process
C2U37_19790	COG1530	ribonuclease E activity
C2U37_19795	COG0564	pseudouridine synthase activity
C2U37_19810	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U37_19815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U37_19820	COG0416	fatty acid biosynthetic process
C2U37_19825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U37_19835	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_19840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U37_19845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U37_19850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U37_19855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U37_19860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U37_19865	COG0470	DNA polymerase III
C2U37_19870	COG0084	hydrolase, TatD family'
C2U37_19885	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U37_19885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_19890	COG3008	intermembrane lipid transfer
C2U37_19895	COG2995	paraquat-inducible protein a
C2U37_19905	COG3141	response to X-ray
C2U37_19915	COG1067	ATP-dependent peptidase activity
C2U37_19920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U37_19945	COG0116	Belongs to the methyltransferase superfamily
C2U37_19945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U37_19955	COG0167	dihydroorotate dehydrogenase activity
C2U37_19960	COG2902	Dehydrogenase
C2U37_19970	COG0308	aminopeptidase N
C2U37_19980	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U37_19985	COG1956	GAF domain-containing protein
C2U37_19995	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U37_20010	COG2010	Cytochrome c
C2U37_20020	COG2217	Heavy metal translocating P-type atpase
C2U37_20035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U37_20040	COG0589	response to stress
C2U37_20045	COG0037	tRNA processing
C2U37_20060	COG0675	Transposase, IS605 OrfB family
C2U37_20070	COG0625	glutathione transferase activity
C2U37_20075	COG1869	D-ribose catabolic process
C2U37_20080	COG1129	ABC transporter
C2U37_20085	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_20090	COG1879	ABC-type sugar transport system periplasmic component
C2U37_20095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_20100	COG1609	Transcriptional regulator
C2U37_20110	COG0675	Transposase, IS605 OrfB family
C2U37_20125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U37_20145	COG0776	regulation of translation
C2U37_20150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_20150	COG0072	phenylalanine-tRNA ligase activity
C2U37_20155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U37_20175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U37_20180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U37_20185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U37_20190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U37_20215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_20225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U37_20230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U37_20235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U37_20240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U37_20245	COG3313	Fe-S protein
C2U37_20250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U37_20250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U37_20250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U37_20255	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U37_20260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_20260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_20265	COG1609	Transcriptional regulator
C2U37_20270	COG0814	amino acid
C2U37_20280	COG5654	RES domain protein
C2U37_20285	COG0513	Belongs to the DEAD box helicase family
C2U37_20295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U37_20300	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U37_20305	COG2840	Smr protein MutS2
C2U37_20340	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U37_20370	COG0588	phosphoglycerate mutase activity
C2U37_20400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U37_20405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U37_20415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_20420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U37_20430	COG0205	6-phosphofructokinase activity
C2U37_20450	COG1473	amidohydrolase
C2U37_20455	COG1011	Hydrolase
C2U37_20460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_20505	COG3593	DNA synthesis involved in DNA repair
C2U37_20520	COG0583	DNA-binding transcription factor activity
C2U37_20525	COG0730	response to heat
C2U37_20535	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U37_20545	COG0386	Belongs to the glutathione peroxidase family
C2U37_20550	COG0513	Belongs to the DEAD box helicase family
C2U37_20565	COG1742	UPF0060 membrane protein
C2U37_20590	COG2329	Antibiotic biosynthesis monooxygenase
C2U37_20595	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U37_20615	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U37_20625	COG2501	S4 domain
C2U37_20640	COG1132	(ABC) transporter
C2U37_20645	COG1132	(ABC) transporter
C2U37_20655	COG3118	belongs to the thioredoxin family
C2U37_20660	COG0471	metal ion transport
C2U37_20670	COG0058	SHG alpha-glucan phosphorylase activity
C2U37_20700	COG0814	amino acid
C2U37_20705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U37_20710	COG0514	ATP-dependent DNA helicase (RecQ)
C2U37_20715	COG2766	serine protein kinase
C2U37_20720	COG2718	Belongs to the UPF0229 family
C2U37_20725	COG2719	SpoVR family
C2U37_20730	COG2186	Transcriptional regulator
C2U37_20735	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U37_20740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U37_20745	COG0586	Pfam SNARE associated Golgi protein
C2U37_20755	COG0556	nucleotide-excision repair
C2U37_20770	COG0569	domain protein
C2U37_20770	COG2985	domain, Protein
C2U37_20775	COG0741	lytic transglycosylase activity
C2U37_20775	COG1196	nuclear chromosome segregation
C2U37_20775	COG0739	heme binding
C2U37_20795	COG4565	transcriptional regulatory protein
C2U37_20805	COG1846	Transcriptional regulator
C2U37_20805	COG1940	carbohydrate kinase activity
C2U37_20810	COG0840	transmembrane signaling receptor activity
C2U37_20815	COG3012	SEC-C Motif Domain Protein
C2U37_20820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U37_20825	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U37_20830	COG0247	lactate metabolic process
C2U37_20855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U37_20860	COG0437	4 iron, 4 sulfur cluster binding
C2U37_20865	COG3301	Polysulphide reductase, NrfD
C2U37_20870	COG1138	Cytochrome C-type biogenesis protein
C2U37_20875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_20880	COG3088	subunit of a heme lyase
C2U37_20880	COG4235	cytochrome complex assembly
C2U37_20895	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U37_20900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_20915	COG0517	IMP dehydrogenase activity
C2U37_20915	COG0516	GMP reductase activity
C2U37_20925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U37_20930	COG0583	DNA-binding transcription factor activity
C2U37_20940	COG4774	siderophore transport
C2U37_20945	COG3706	GGDEF domain
C2U37_20950	COG2200	EAL domain
C2U37_20955	COG4977	sequence-specific DNA binding
C2U37_20955	COG1917	Cupin 2, conserved barrel domain protein
C2U37_20960	COG0583	DNA-binding transcription factor activity
C2U37_20965	COG2910	NAD(P)H-binding
C2U37_20980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U37_21010	COG2226	methyltransferase
C2U37_21050	COG1462	curli production assembly transport component CsgG
C2U37_21065	COG2197	response regulator
C2U37_21080	COG3039	Transposase
C2U37_21120	COG3039	Transposase
C2U37_21130	COG1484	DNA-dependent DNA replication
C2U37_21135	COG4584	PFAM Integrase catalytic
C2U37_21180	COG3550	peptidyl-serine autophosphorylation
C2U37_21195	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U37_21200	COG1349	DNA-binding transcription factor activity
C2U37_21225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_21245	COG3039	Transposase
C2U37_21255	COG4974	Belongs to the 'phage' integrase family
C2U37_21280	COG1435	thymidine kinase activity
C2U37_21285	COG1757	Na H antiporter
C2U37_21290	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_21295	COG2096	Adenosyltransferase
C2U37_21305	COG3530	Putative quorum-sensing-regulated virulence factor
C2U37_21310	COG0602	queuosine metabolic process
C2U37_21315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U37_21335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U37_21345	COG0776	regulation of translation
C2U37_21350	COG0539	negative regulation of cytoplasmic translation
C2U37_21355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U37_21360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U37_21390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U37_21395	COG5001	Diguanylate cyclase
C2U37_21395	COG3300	MHYT domain
C2U37_21405	COG0583	DNA-binding transcription factor activity
C2U37_21410	COG0745	RESPONSE REGULATOR receiver
C2U37_21435	COG4989	oxidoreductase activity
C2U37_21440	COG0724	RNA recognition motif
C2U37_21450	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U37_21460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U37_21480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_21485	COG1360	Flagellar Motor Protein
C2U37_21490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_21495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_21500	COG0649	NAD binding
C2U37_21500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_21515	COG1034	ATP synthesis coupled electron transport
C2U37_21520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U37_21525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_21530	COG0839	Belongs to the complex I subunit 6 family
C2U37_21535	COG0713	ATP synthesis coupled electron transport
C2U37_21545	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_21550	COG1007	ATP synthesis coupled electron transport
C2U37_21555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U37_21555	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U37_21560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U37_21565	COG1645	bacterial-type flagellum-dependent swarming motility
C2U37_21570	COG1160	GTP binding
C2U37_21575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_21580	COG2976	Protein conserved in bacteria
C2U37_21585	COG0124	histidyl-tRNA synthetase
C2U37_21595	COG1426	Protein conserved in bacteria
C2U37_21605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U37_21610	COG0105	UTP biosynthetic process
C2U37_21615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_21625	COG0633	Ferredoxin
C2U37_21630	COG0443	Heat shock 70 kDa protein
C2U37_21635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U37_21645	COG0822	iron-sulfur transferase activity
C2U37_21650	COG1104	cysteine desulfurase activity
C2U37_21685	COG2897	thiosulfate sulfurtransferase activity
C2U37_21690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_21695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_21700	COG1862	Preprotein translocase
C2U37_21705	COG0343	queuine tRNA-ribosyltransferase activity
C2U37_21710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U37_21715	COG0517	IMP dehydrogenase activity
C2U37_21720	COG0450	alkyl hydroperoxide reductase
C2U37_21725	COG3634	alkyl hydroperoxide reductase activity
C2U37_21765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U37_21815	COG4584	PFAM Integrase catalytic
C2U37_21820	COG1484	DNA-dependent DNA replication
C2U37_21835	COG3039	Transposase
C2U37_21840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U37_21840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U37_21845	COG0509	glycine decarboxylation via glycine cleavage system
C2U37_21850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U37_21855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_21860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_21880	COG2814	Major facilitator Superfamily
C2U37_21885	COG0444	Belongs to the ABC transporter superfamily
C2U37_21890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_21895	COG0601	transmembrane transport
C2U37_21905	COG0625	glutathione transferase activity
C2U37_21910	COG0625	glutathione transferase activity
C2U37_21920	COG0483	inositol monophosphate 1-phosphatase activity
C2U37_21935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_21940	COG2056	Na+-H+ antiporter family
C2U37_21945	COG2814	Major facilitator Superfamily
C2U37_21950	COG0583	DNA-binding transcription factor activity
C2U37_21955	COG5001	Diguanylate cyclase
C2U37_21970	COG2050	protein possibly involved in aromatic compounds catabolism
C2U37_21980	COG0247	lactate metabolic process
C2U37_21980	COG0277	FAD linked oxidase domain protein
C2U37_21995	COG1253	flavin adenine dinucleotide binding
C2U37_22000	COG1902	pentaerythritol trinitrate reductase activity
C2U37_22010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U37_22015	COG0647	UMP catabolic process
C2U37_22025	COG0367	asparagine synthase
C2U37_22040	COG0625	glutathione transferase activity
C2U37_22050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U37_22065	COG0564	pseudouridine synthase activity
C2U37_22075	COG5001	Diguanylate cyclase
C2U37_22095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U37_22135	COG0670	Belongs to the BI1 family
C2U37_22140	COG1289	transmembrane transporter activity
C2U37_22145	COG2920	part of a sulfur-relay system
C2U37_22150	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U37_22155	COG0285	dihydrofolate synthase activity
C2U37_22160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U37_22165	COG0101	tRNA pseudouridine synthase activity
C2U37_22175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U37_22180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U37_22190	COG1464	Belongs to the NlpA lipoprotein family
C2U37_22215	COG1119	ATPase activity
C2U37_22220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U37_22220	COG0574	Belongs to the PEP-utilizing enzyme family
C2U37_22225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U37_22235	COG1113	amino acid transport
C2U37_22280	COG1242	4 iron, 4 sulfur cluster binding
C2U37_22285	COG0070	glutamate synthase
C2U37_22285	COG0069	glutamate synthase activity
C2U37_22285	COG0067	glutamate synthase
C2U37_22290	COG0493	'glutamate synthase
C2U37_22300	COG0765	amino acid transport
C2U37_22305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_22330	COG4104	PAAR repeat-containing protein
C2U37_22340	COG0513	Belongs to the DEAD box helicase family
C2U37_22375	COG3706	GGDEF domain
C2U37_22380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U37_22420	COG3451	type IV secretory pathway VirB4
C2U37_22430	COG3838	Conjugal transfer protein Trbc
C2U37_22435	COG4962	Type ii secretion system protein e
C2U37_22455	COG0583	DNA-binding transcription factor activity
C2U37_22480	COG2076	Multidrug Resistance protein
C2U37_22505	COG4959	Type IV secretory pathway protease TraF
C2U37_22520	COG1192	Involved in chromosome partitioning
C2U37_22590	COG3077	Addiction module antitoxin, RelB DinJ family
C2U37_22600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U37_22615	COG4804	nuclease activity
C2U37_22630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U37_22635	COG0505	Belongs to the CarA family
C2U37_22640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U37_22650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U37_22655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U37_22660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U37_22665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U37_22670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_22680	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U37_22710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2U37_22720	COG0023	Translation Initiation Factor
C2U37_22725	COG2119	membrane
C2U37_22760	COG2199	diguanylate cyclase activity
C2U37_22760	COG2203	Gaf domain
C2U37_22770	COG3039	Transposase
C2U37_22785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U37_22795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_22800	COG2261	transglycosylase associated protein
C2U37_22805	COG1309	transcriptional regulator
C2U37_22810	COG0604	alcohol dehydrogenase
C2U37_22820	COG2801	Transposase and inactivated derivatives
C2U37_22910	COG0322	excinuclease ABC activity
C2U37_22915	COG2197	response regulator
C2U37_22920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U37_22925	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U37_22930	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U37_22935	COG1132	(ABC) transporter
C2U37_22940	COG0658	competence protein
C2U37_22940	COG2333	competence protein COMEC
C2U37_22955	COG0433	COG0433 Predicted ATPase
C2U37_22960	COG1448	Aminotransferase
C2U37_22975	COG3385	transposase activity
C2U37_22985	COG1199	ATP-dependent helicase activity
C2U37_22995	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U37_23000	COG0477	Major facilitator Superfamily
C2U37_23005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U37_23010	COG1785	Belongs to the alkaline phosphatase family
C2U37_23030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U37_23035	COG3706	GGDEF domain
C2U37_23040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_23045	COG0765	amino acid transport
C2U37_23050	COG1126	abc transporter atp-binding protein
C2U37_23060	COG0531	amino acid
C2U37_23075	COG1253	flavin adenine dinucleotide binding
C2U37_23080	COG0704	Plays a role in the regulation of phosphate uptake
C2U37_23090	COG0581	inorganic phosphate transmembrane transporter activity
C2U37_23095	COG0573	inorganic phosphate transmembrane transporter activity
C2U37_23100	COG0590	tRNA wobble adenosine to inosine editing
C2U37_23115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U37_23135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U37_23140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U37_23145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U37_23150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U37_23155	COG2204	response regulator
C2U37_23160	COG3852	Histidine kinase
C2U37_23165	COG2204	response regulator
C2U37_23175	COG2716	regulation of RNA biosynthetic process
C2U37_23180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U37_23185	COG0248	Ppx GppA phosphatase
C2U37_23190	COG2239	Acts as a magnesium transporter
C2U37_23205	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U37_23205	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U37_23210	COG1706	bacterial-type flagellum-dependent cell motility
C2U37_23215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U37_23220	COG4786	Flagellar basal body rod
C2U37_23230	COG1749	Flagellar hook protein flgE
C2U37_23240	COG1558	bacterial-type flagellum-dependent cell motility
C2U37_23245	COG1815	bacterial-type flagellum-dependent cell motility
C2U37_23250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U37_23255	COG0784	Response regulator, receiver
C2U37_23255	COG0835	chemotaxis
C2U37_23260	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U37_23275	COG0622	Phosphoesterase
C2U37_23280	COG4166	transmembrane transport
C2U37_23290	COG1187	pseudouridine synthase activity
C2U37_23295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_23305	COG0697	spore germination
C2U37_23310	COG4166	transmembrane transport
C2U37_23335	COG1278	Cold shock
C2U37_23375	COG3132	Protein of unknown function, DUF480
C2U37_23405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U37_23410	COG1215	transferase activity, transferring glycosyl groups
C2U37_23425	COG2244	polysaccharide biosynthetic process
C2U37_23435	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_23440	COG1083	cytidylyl-transferase
C2U37_23445	COG0673	inositol 2-dehydrogenase activity
C2U37_23460	COG2089	acid synthase
C2U37_23465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U37_23470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U37_23485	COG0745	RESPONSE REGULATOR receiver
C2U37_23500	COG1737	Transcriptional regulator
C2U37_23505	COG0469	pyruvate kinase activity
C2U37_23515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_23520	COG1960	acyl-CoA dehydrogenase activity
C2U37_23530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U37_23545	COG4983	Phage plasmid primase, P4 family domain protein
C2U37_23570	COG4584	PFAM Integrase catalytic
C2U37_23575	COG1484	DNA-dependent DNA replication
C2U37_23590	COG3039	Transposase
C2U37_23605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U37_23630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_23670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_23690	COG1538	Outer membrane efflux protein
C2U37_23695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_23700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_23705	COG1309	transcriptional regulator
C2U37_23720	COG1946	Acyl-CoA thioesterase
C2U37_23735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U37_23745	COG0009	L-threonylcarbamoyladenylate synthase
C2U37_23750	COG0613	PHP domain protein
C2U37_23755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U37_23760	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U37_23760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U37_23765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U37_23770	COG0134	indole-3-glycerol-phosphate synthase activity
C2U37_23770	COG0135	phosphoribosylanthranilate isomerase activity
C2U37_23775	COG0133	tryptophan synthase activity
C2U37_23780	COG0159	tryptophan synthase activity
C2U37_23790	COG3039	Transposase
C2U37_23825	COG4521	taurine ABC transporter
C2U37_23830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U37_23835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U37_23840	COG2175	clavaminate synthase activity
C2U37_23850	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U37_23855	COG2814	Major facilitator Superfamily
C2U37_23860	COG0109	protoheme IX farnesyltransferase activity
C2U37_23865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U37_23870	COG1845	cytochrome c oxidase, subunit III
C2U37_23875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U37_23880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U37_23890	COG0583	DNA-binding transcription factor activity
C2U37_23910	COG1846	Transcriptional regulator
C2U37_23925	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U37_23945	COG2026	Addiction module toxin, RelE StbE family
C2U37_23950	COG3077	Addiction module antitoxin, RelB DinJ family
C2U37_23955	COG1192	Involved in chromosome partitioning
C2U37_23965	COG4644	lycopene metabolic process
C2U37_23995	COG3385	transposase activity
C2U37_24135	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_24145	COG3316	Transposase and inactivated derivatives
C2U37_24150	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_24155	COG3173	Aminoglycoside phosphotransferase
C2U37_24160	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_24170	COG3316	Transposase and inactivated derivatives
C2U37_24175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U37_24190	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_24210	COG3316	Transposase and inactivated derivatives
C2U37_24325	COG0789	Transcriptional regulator
C2U37_24330	COG2608	mercury ion transmembrane transporter activity
C2U37_24335	COG2608	mercury ion transmembrane transporter activity
C2U37_24345	COG0789	Transcriptional regulator
C2U37_24455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U37_24495	COG0840	transmembrane signaling receptor activity