locus-tag	class	description
C2U39_00005	COG1609	Transcriptional regulator
C2U39_00010	COG3250	beta-galactosidase activity
C2U39_00015	COG2731	YhcH YjgK YiaL family protein
C2U39_00020	COG0531	amino acid
C2U39_00025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U39_00030	COG0531	amino acid
C2U39_00035	COG0385	Bile acid
C2U39_00040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U39_00065	COG0583	DNA-binding transcription factor activity
C2U39_00090	COG0210	DNA helicase
C2U39_00110	COG1943	Transposase
C2U39_00130	COG2801	Transposase and inactivated derivatives
C2U39_00135	COG2842	Transposition protein
C2U39_00245	COG0640	Transcriptional regulator
C2U39_00260	COG4373	Mu-like prophage FluMu protein gp28
C2U39_00265	COG4383	Mu-like prophage protein gp29
C2U39_00280	COG4397	Mu-like prophage major head subunit gpT
C2U39_00325	COG4386	tail sheath protein
C2U39_00355	COG4384	Bacteriophage Mu Gp45 protein
C2U39_00365	COG3299	homolog of phage Mu protein gp47
C2U39_00380	COG0583	DNA-binding transcription factor activity
C2U39_00415	COG0583	DNA-binding transcription factor activity
C2U39_00430	COG1280	lysine exporter protein (LysE YggA)
C2U39_00440	COG2962	Rard protein
C2U39_00445	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_00450	COG1396	sequence-specific DNA binding
C2U39_00465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U39_00465	COG0519	Catalyzes the synthesis of GMP from XMP
C2U39_00475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U39_00495	COG1322	Protein conserved in bacteria
C2U39_00500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U39_00505	COG0569	domain protein
C2U39_00510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U39_00510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U39_00515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U39_00520	COG0242	peptide deformylase activity
C2U39_00530	COG0758	DNA mediated transformation
C2U39_00535	COG2922	Belongs to the Smg family
C2U39_00540	COG0551	DNA topoisomerase type I activity
C2U39_00545	COG0009	L-threonylcarbamoyladenylate synthase
C2U39_00550	COG0408	coproporphyrinogen oxidase activity
C2U39_00555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U39_00560	COG3385	transposase activity
C2U39_00570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U39_00580	COG3078	GTPase activator activity
C2U39_00590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U39_00595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U39_00600	COG2204	response regulator
C2U39_00605	COG3852	Histidine kinase
C2U39_00615	COG0174	glutamine synthetase
C2U39_00625	COG1295	ribonuclease BN
C2U39_00630	COG1490	D-aminoacyl-tRNA deacylase activity
C2U39_00640	COG0456	acetyltransferase
C2U39_00650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U39_00655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U39_00660	COG2610	gluconate transmembrane transporter activity
C2U39_00665	COG3265	gluconokinase activity
C2U39_00670	COG0129	dihydroxy-acid dehydratase activity
C2U39_00675	COG0800	Aldolase
C2U39_00690	COG1609	Transcriptional regulator
C2U39_00700	COG4942	peptidase
C2U39_00705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U39_00710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U39_00715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U39_00720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U39_00725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U39_00725	COG0316	Belongs to the HesB IscA family
C2U39_00730	COG1040	competence protein
C2U39_00735	COG0596	Alpha beta hydrolase
C2U39_00750	COG2183	response to ionizing radiation
C2U39_00755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U39_00760	COG0745	RESPONSE REGULATOR receiver
C2U39_00765	COG2205	protein histidine kinase activity
C2U39_00775	COG0051	transcription antitermination factor activity, RNA binding
C2U39_00780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U39_00785	COG0088	Forms part of the polypeptide exit tunnel
C2U39_00790	COG0089	rRNA binding
C2U39_00795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U39_00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U39_00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U39_00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U39_00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U39_00820	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U39_00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U39_00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U39_00835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U39_00840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U39_00845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U39_00850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U39_00855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U39_00860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U39_00865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U39_00870	COG1841	ribosomal large subunit assembly
C2U39_00875	COG0200	Binds to the 23S rRNA
C2U39_00880	COG0201	protein transport
C2U39_00885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U39_00890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U39_00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U39_00900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U39_00905	COG0202	RNA polymerase activity
C2U39_00910	COG0203	ribosomal protein L17
C2U39_00975	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U39_00980	COG0583	DNA-binding transcription factor activity
C2U39_00985	COG4221	oxidoreductase activity
C2U39_01000	COG1770	oligopeptidase
C2U39_01020	COG3714	YhhN family
C2U39_01035	COG0583	DNA-binding transcription factor activity
C2U39_01045	COG1301	dicarboxylic acid transport
C2U39_01055	COG2095	MarC family integral membrane protein
C2U39_01065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U39_01075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U39_01080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U39_01105	COG0742	ribosomal rna small subunit methyltransferase
C2U39_01110	COG0552	protein localization to endoplasmic reticulum
C2U39_01115	COG2884	Cell division ATP-binding protein ftsE
C2U39_01120	COG2177	Part of the ABC transporter FtsEX involved in
C2U39_01130	COG0288	reversible hydration of carbon dioxide
C2U39_01135	COG2188	Transcriptional regulator
C2U39_01140	COG1228	amidohydrolase
C2U39_01145	COG0010	Belongs to the arginase family
C2U39_01150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U39_01155	COG2986	histidine ammonia-lyase
C2U39_01160	COG0387	Pfam Sodium calcium exchanger
C2U39_01165	COG2200	EAL domain
C2U39_01220	COG1459	type II secretion system
C2U39_01265	COG1077	Cell shape determining protein MreB Mrl
C2U39_01270	COG1792	Involved in formation and maintenance of cell shape
C2U39_01275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U39_01280	COG0424	maF-like protein
C2U39_01285	COG1530	ribonuclease E activity
C2U39_01290	COG3164	Protein of unknown function
C2U39_01295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U39_01300	COG0312	modulator of DNA gyrase
C2U39_01315	COG0477	Major facilitator Superfamily
C2U39_01325	COG2321	neutral zinc metallopeptidase
C2U39_01360	COG0189	ligase activity
C2U39_01370	COG0745	RESPONSE REGULATOR receiver
C2U39_01385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U39_01390	COG0352	thiamine-phosphate diphosphorylase activity
C2U39_01395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U39_01405	COG2022	thiamine diphosphate biosynthetic process
C2U39_01410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U39_01425	COG0110	maltose O-acetyltransferase activity
C2U39_01435	COG2203	Gaf domain
C2U39_01435	COG2199	diguanylate cyclase activity
C2U39_01440	COG3932	Exopolysaccharide synthesis, ExoD
C2U39_01455	COG1733	regulation of RNA biosynthetic process
C2U39_01485	COG2226	methyltransferase
C2U39_01495	COG1494	fructose-1,6-bisphosphatase
C2U39_01505	COG3071	HemY protein
C2U39_01510	COG2959	enzyme of heme biosynthesis
C2U39_01520	COG0181	hydroxymethylbilane synthase activity
C2U39_01525	COG3072	Adenylate cyclase
C2U39_01530	COG0400	carboxylic ester hydrolase activity
C2U39_01535	COG1965	Belongs to the frataxin family
C2U39_01545	COG0019	diaminopimelate decarboxylase activity
C2U39_01550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U39_01565	COG1011	Hydrolase
C2U39_01575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U39_01580	COG0561	phosphatase activity
C2U39_01590	COG1988	membrane-bound metal-dependent
C2U39_01595	COG1058	Belongs to the CinA family
C2U39_01595	COG1546	Belongs to the CinA family
C2U39_01605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U39_01615	COG1522	sequence-specific DNA binding
C2U39_01620	COG1368	sulfuric ester hydrolase activity
C2U39_01635	COG1285	pathogenesis
C2U39_01655	COG4221	oxidoreductase activity
C2U39_01670	COG1979	alcohol dehydrogenase
C2U39_01680	COG2873	o-acetylhomoserine
C2U39_01710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U39_01725	COG2949	membrane
C2U39_01730	COG3291	Pkd domain containing protein
C2U39_01735	COG0318	PFAM AMP-dependent synthetase and ligase
C2U39_01745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U39_01750	COG0596	Alpha beta hydrolase
C2U39_01755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U39_01760	COG1169	isochorismate synthase
C2U39_01765	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U39_01785	COG0513	Belongs to the DEAD box helicase family
C2U39_01800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U39_01815	COG1671	Belongs to the UPF0178 family
C2U39_01835	COG3263	regulation of cellular component size
C2U39_01840	COG3722	fumarate hydratase activity
C2U39_01845	COG0246	Mannitol dehydrogenase
C2U39_01850	COG2213	PTS system mannitol-specific
C2U39_01850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_01855	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U39_01865	COG3916	Acyl-homoserine-lactone synthase
C2U39_01870	COG2771	luxR family
C2U39_01885	COG1560	Kdo2-lipid A biosynthetic process
C2U39_01890	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U39_01890	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U39_01895	COG1538	Outer membrane efflux protein
C2U39_01900	COG0494	nUDIX hydrolase
C2U39_01905	COG3151	Protein conserved in bacteria
C2U39_01915	COG3150	esterase
C2U39_01920	COG1051	belongs to the nudix hydrolase family
C2U39_01935	COG1566	PFAM secretion protein HlyD family protein
C2U39_01940	COG1289	transmembrane transporter activity
C2U39_01945	COG0187	DNA topoisomerase II activity
C2U39_01975	COG0004	ammonium transporteR
C2U39_01980	COG0347	Belongs to the P(II) protein family
C2U39_01985	COG3706	GGDEF domain
C2U39_02005	COG0745	RESPONSE REGULATOR receiver
C2U39_02010	COG2205	protein histidine kinase activity
C2U39_02015	COG1278	Cold shock
C2U39_02040	COG2197	response regulator
C2U39_02045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U39_02060	COG3047	cAMP biosynthetic process
C2U39_02095	COG3135	benzoate transporter
C2U39_02100	COG1396	sequence-specific DNA binding
C2U39_02130	COG2926	Belongs to the UPF0265 family
C2U39_02140	COG3028	Belongs to the UPF0307 family
C2U39_02145	COG0312	modulator of DNA gyrase
C2U39_02150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U39_02155	COG5007	Belongs to the BolA IbaG family
C2U39_02165	COG2854	intermembrane phospholipid transfer
C2U39_02170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U39_02175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U39_02180	COG1127	ABC transporter
C2U39_02185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U39_02185	COG0517	IMP dehydrogenase activity
C2U39_02190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U39_02200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U39_02205	COG1137	ATPase activity
C2U39_02210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U39_02220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_02225	COG1660	Displays ATPase and GTPase activities
C2U39_02230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_02250	COG3964	amidohydrolase
C2U39_02280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U39_02285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U39_02295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U39_02300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U39_02305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U39_02310	COG0723	plastoquinol--plastocyanin reductase activity
C2U39_02315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U39_02320	COG2857	Cytochrome c1
C2U39_02325	COG0625	glutathione transferase activity
C2U39_02330	COG2969	positive regulation of protein catabolic process
C2U39_02335	COG2823	Periplasmic or secreted lipoprotein
C2U39_02340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U39_02345	COG0792	nuclease activity
C2U39_02350	COG3107	peptidoglycan biosynthetic process
C2U39_02355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U39_02380	COG1987	bacterial-type flagellum assembly
C2U39_02400	COG2204	response regulator
C2U39_02405	COG1677	Flagellar hook-basal body complex protein FliE
C2U39_02415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U39_02445	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U39_02450	COG1815	bacterial-type flagellum-dependent cell motility
C2U39_02455	COG1558	bacterial-type flagellum-dependent cell motility
C2U39_02460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2U39_02465	COG1749	Flagellar hook protein flgE
C2U39_02475	COG4786	Flagellar basal body rod
C2U39_02480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U39_02485	COG1706	bacterial-type flagellum-dependent cell motility
C2U39_02495	COG1256	bacterial-type flagellum assembly
C2U39_02495	COG4786	Flagellar basal body rod
C2U39_02500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U39_02520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U39_02525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U39_02530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U39_02555	COG1191	sigma factor activity
C2U39_02560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U39_02565	COG1360	Flagellar Motor Protein
C2U39_02575	COG0741	lytic transglycosylase activity
C2U39_02575	COG1388	LysM domain
C2U39_02585	COG2001	Belongs to the MraZ family
C2U39_02590	COG0275	rRNA processing
C2U39_02595	COG3116	cell division
C2U39_02600	COG0768	penicillin binding
C2U39_02605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U39_02610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U39_02615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U39_02620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U39_02625	COG0772	Belongs to the SEDS family
C2U39_02630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U39_02635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U39_02640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U39_02645	COG0849	cell division
C2U39_02650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U39_02655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U39_02665	COG0653	protein targeting
C2U39_02675	COG0494	nUDIX hydrolase
C2U39_02680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U39_02685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U39_02695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2U39_02700	COG1459	type II secretion system
C2U39_02705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U39_02735	COG2186	Transcriptional regulator
C2U39_02740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U39_02745	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U39_02750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U39_02760	COG0840	transmembrane signaling receptor activity
C2U39_02765	COG0840	transmembrane signaling receptor activity
C2U39_02770	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U39_02775	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U39_02780	COG2200	EAL domain
C2U39_02790	COG1280	lysine exporter protein (LysE YggA)
C2U39_02800	COG0523	cobalamin synthesis protein
C2U39_02805	COG0477	Major facilitator Superfamily
C2U39_02820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U39_02825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U39_02870	COG5006	permease, DMT superfamily
C2U39_02875	COG1522	sequence-specific DNA binding
C2U39_02880	COG0110	maltose O-acetyltransferase activity
C2U39_02885	COG0366	Alpha amylase catalytic
C2U39_02890	COG1263	PTS System
C2U39_02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U39_02910	COG0252	asparaginase activity
C2U39_02925	COG1803	Methylglyoxal synthase
C2U39_02945	COG1444	tRNA N-acetyltransferase activity
C2U39_02950	COG1565	acr, cog1565
C2U39_02950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U39_02960	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U39_02990	COG0109	protoheme IX farnesyltransferase activity
C2U39_02995	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_03000	COG1177	transmembrane transport
C2U39_03005	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U39_03010	COG3842	ATPase activity
C2U39_03015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U39_03020	COG0583	DNA-binding transcription factor activity
C2U39_03025	COG1757	Na H antiporter
C2U39_03065	COG0297	glycogen (starch) synthase activity
C2U39_03070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U39_03075	COG2813	Specifically methylates the guanine in position
C2U39_03080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U39_03085	COG5001	Diguanylate cyclase
C2U39_03085	COG2203	Gaf domain
C2U39_03085	COG4251	negative regulation of phosphorylation
C2U39_03085	COG3706	GGDEF domain
C2U39_03090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U39_03100	COG2995	paraquat-inducible protein a
C2U39_03105	COG3008	intermembrane lipid transfer
C2U39_03105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U39_03110	COG3009	Protein conserved in bacteria
C2U39_03120	COG3240	lipase activity
C2U39_03135	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U39_03140	COG1194	a g-specific adenine glycosylase
C2U39_03150	COG3409	Peptidoglycan-binding domain 1 protein
C2U39_03150	COG3267	Type II secretory pathway component ExeA
C2U39_03155	COG0617	tRNA 3'-terminal CCA addition
C2U39_03160	COG0306	phosphate transporter
C2U39_03165	COG1392	Phosphate transport regulator
C2U39_03170	COG3025	triphosphatase activity
C2U39_03175	COG3133	Outer membrane lipoprotein
C2U39_03180	COG0456	acetyltransferase
C2U39_03195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U39_03200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U39_03210	COG3031	protein transport across the cell outer membrane
C2U39_03220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U39_03225	COG1459	type II secretion system
C2U39_03230	COG2165	general secretion pathway protein
C2U39_03240	COG2165	general secretion pathway protein
C2U39_03245	COG4795	General secretion pathway protein
C2U39_03255	COG3156	type II secretion system protein K
C2U39_03265	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U39_03280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U39_03295	COG1011	Hydrolase
C2U39_03300	COG0494	nUDIX hydrolase
C2U39_03305	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U39_03310	COG0814	amino acid
C2U39_03315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U39_03330	COG0626	cystathionine gamma-synthase activity
C2U39_03335	COG0460	homoserine dehydrogenase
C2U39_03335	COG0527	aspartate kinase activity
C2U39_03340	COG1346	cytolysis
C2U39_03345	COG1380	Effector of murein hydrolase LrgA
C2U39_03350	COG0583	DNA-binding transcription factor activity
C2U39_03385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U39_03390	COG5002	protein histidine kinase activity
C2U39_03390	COG5001	Diguanylate cyclase
C2U39_03390	COG3447	MASE1 domain protein
C2U39_03395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U39_03405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U39_03410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U39_03420	COG0137	argininosuccinate synthase activity
C2U39_03425	COG0165	Argininosuccinate lyase
C2U39_03430	COG0583	DNA-binding transcription factor activity
C2U39_03440	COG1942	4-Oxalocrotonate Tautomerase
C2U39_03470	COG0110	maltose O-acetyltransferase activity
C2U39_03475	COG3174	membrane
C2U39_03485	COG1126	abc transporter atp-binding protein
C2U39_03490	COG0765	amino acid transport
C2U39_03495	COG0765	amino acid transport
C2U39_03500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U39_03505	COG1505	serine-type exopeptidase activity
C2U39_03520	COG1028	Short-chain dehydrogenase reductase Sdr
C2U39_03525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U39_03540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U39_03545	COG4991	sh3 domain protein
C2U39_03555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U39_03560	COG1940	carbohydrate kinase activity
C2U39_03565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U39_03570	COG0126	phosphoglycerate kinase activity
C2U39_03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U39_03615	COG0583	DNA-binding transcription factor activity
C2U39_03620	COG0354	folic acid binding
C2U39_03625	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U39_03635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U39_03640	COG1595	DNA-templated transcription, initiation
C2U39_03645	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U39_03660	COG0481	GTPase activity
C2U39_03665	COG0681	Belongs to the peptidase S26 family
C2U39_03670	COG0571	ribonuclease III activity
C2U39_03680	COG1381	Involved in DNA repair and RecF pathway recombination
C2U39_03685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U39_03690	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U39_03695	COG4807	Protein conserved in bacteria
C2U39_03705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U39_03710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U39_03715	COG3956	TIGRFAM MazG family protein
C2U39_03720	COG0504	CTP synthase activity
C2U39_03725	COG0148	phosphopyruvate hydratase activity
C2U39_03730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U39_03735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U39_03745	COG0585	pseudouridine synthase activity
C2U39_03750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U39_03755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U39_03760	COG1238	metal cluster binding
C2U39_03765	COG1388	LysM domain
C2U39_03765	COG4942	peptidase
C2U39_03775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U39_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U39_03785	COG1610	YqeY-like protein
C2U39_03790	COG0358	DNA primase activity
C2U39_03795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U39_03825	COG0151	Belongs to the GarS family
C2U39_03830	COG0138	bifunctional purine biosynthesis protein purh
C2U39_03845	COG3036	rescue of stalled ribosome
C2U39_03850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U39_03855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U39_03865	COG0673	inositol 2-dehydrogenase activity
C2U39_03875	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U39_03880	COG0330	HflC and HflK could
C2U39_03885	COG1648	precorrin-2 dehydrogenase activity
C2U39_03885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U39_03890	COG0175	sulfate reduction
C2U39_03895	COG2895	sulfate adenylyltransferase (ATP) activity
C2U39_03900	COG0471	metal ion transport
C2U39_03900	COG3273	potassium ion transport
C2U39_03905	COG0529	Catalyzes the synthesis of activated sulfate
C2U39_03955	COG0840	transmembrane signaling receptor activity
C2U39_03975	COG1136	(ABC) transporter
C2U39_03990	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U39_04005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U39_04010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U39_04015	COG0163	prenyltransferase activity
C2U39_04030	COG1131	(ABC) transporter
C2U39_04035	COG0842	Transport permease protein
C2U39_04045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U39_04050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U39_04055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U39_04065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U39_04070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U39_04075	COG1489	DNA binding
C2U39_04085	COG1643	Atp-dependent helicase
C2U39_04090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U39_04095	COG0346	lactoylglutathione lyase activity
C2U39_04110	COG0583	DNA-binding transcription factor activity
C2U39_04120	COG0671	phosphoesterase, PA-phosphatase related
C2U39_04135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U39_04140	COG0038	chloride channel
C2U39_04150	COG0316	Belongs to the HesB IscA family
C2U39_04175	COG1280	lysine exporter protein (LysE YggA)
C2U39_04180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U39_04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_04225	COG0745	RESPONSE REGULATOR receiver
C2U39_04230	COG3104	oligopeptide transport
C2U39_04235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U39_04240	COG1555	photosystem II stabilization
C2U39_04250	COG2350	Protein conserved in bacteria
C2U39_04255	COG2917	probably involved in intracellular septation
C2U39_04260	COG0076	glutamate decarboxylase activity
C2U39_04265	COG1272	protein, Hemolysin III
C2U39_04270	COG2985	domain, Protein
C2U39_04270	COG0569	domain protein
C2U39_04280	COG0477	Major facilitator Superfamily
C2U39_04285	COG0583	DNA-binding transcription factor activity
C2U39_04290	COG3227	Zinc metalloprotease (Elastase)
C2U39_04295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U39_04300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U39_04310	COG2731	YhcH YjgK YiaL family protein
C2U39_04320	COG0668	transmembrane transport
C2U39_04340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U39_04350	COG0789	Transcriptional regulator
C2U39_04390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U39_04400	COG0488	(ABC) transporter
C2U39_04405	COG0516	GMP reductase activity
C2U39_04405	COG0517	IMP dehydrogenase activity
C2U39_04415	COG0784	Response regulator, receiver
C2U39_04415	COG0835	chemotaxis
C2U39_04420	COG2755	lipolytic protein G-D-S-L family
C2U39_04425	COG4181	ATPase activity
C2U39_04430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U39_04435	COG1090	epimerase
C2U39_04440	COG2200	EAL domain
C2U39_04445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U39_04450	COG2234	aminopeptidase activity
C2U39_04450	COG4935	Belongs to the peptidase S8 family
C2U39_04455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U39_04460	COG3171	Protein conserved in bacteria
C2U39_04465	COG2066	Belongs to the glutaminase family
C2U39_04470	COG2897	thiosulfate sulfurtransferase activity
C2U39_04475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U39_04525	COG1132	(ABC) transporter
C2U39_04550	COG0582	viral genome integration into host DNA
C2U39_04565	COG4974	Belongs to the 'phage' integrase family
C2U39_04610	COG4251	negative regulation of phosphorylation
C2U39_04610	COG2203	Gaf domain
C2U39_04610	COG5001	Diguanylate cyclase
C2U39_04610	COG3706	GGDEF domain
C2U39_04620	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U39_04625	COG3300	MHYT domain
C2U39_04625	COG5001	Diguanylate cyclase
C2U39_04645	COG4628	conserved protein (DUF2132)
C2U39_04650	COG0688	phosphatidylethanolamine metabolic process
C2U39_04655	COG1162	GTPase activity
C2U39_04660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U39_04700	COG1278	Cold shock
C2U39_04710	COG0840	transmembrane signaling receptor activity
C2U39_04715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U39_04720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U39_04770	COG0848	biopolymer transport protein
C2U39_04775	COG0811	peptide transport
C2U39_04780	COG0811	peptide transport
C2U39_04790	COG4206	TonB-dependent receptor
C2U39_04805	COG4174	ABC transporter (Permease)
C2U39_04810	COG4239	(ABC) transporter, permease
C2U39_04820	COG0444	Belongs to the ABC transporter superfamily
C2U39_04825	COG4608	Belongs to the ABC transporter superfamily
C2U39_04835	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U39_04845	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U39_04865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U39_04890	COG0243	molybdopterin cofactor binding
C2U39_04895	COG1648	precorrin-2 dehydrogenase activity
C2U39_04895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U39_04905	COG1116	anion transmembrane transporter activity
C2U39_04905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U39_04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U39_04915	COG1116	anion transmembrane transporter activity
C2U39_04920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U39_04920	COG2146	nitrite reductase [NAD(P)H] activity
C2U39_04925	COG2146	nitrite reductase [NAD(P)H] activity
C2U39_04925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U39_04930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U39_04935	COG2313	pseudouridylate synthase activity
C2U39_04945	COG3385	transposase activity
C2U39_04965	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U39_04975	COG2966	Psort location CytoplasmicMembrane, score
C2U39_04980	COG3610	response to peptide
C2U39_04990	COG4175	Glycine betaine
C2U39_04995	COG4176	ABC-type proline glycine betaine transport system permease component
C2U39_05000	COG2113	Glycine betaine
C2U39_05005	COG0175	sulfate reduction
C2U39_05010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U39_05015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U39_05020	COG0384	phenazine biosynthesis protein PhzF
C2U39_05025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U39_05040	COG0786	glutamate:sodium symporter activity
C2U39_05045	COG0252	asparaginase activity
C2U39_05050	COG3139	Protein of unknown function (DUF1315)
C2U39_05070	COG0616	signal peptide processing
C2U39_05075	COG1902	pentaerythritol trinitrate reductase activity
C2U39_05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U39_05080	COG0778	Nitroreductase
C2U39_05105	COG2264	protein methyltransferase activity
C2U39_05110	COG0604	alcohol dehydrogenase
C2U39_05115	COG0583	DNA-binding transcription factor activity
C2U39_05125	COG4145	pantothenate transmembrane transporter activity
C2U39_05130	COG3924	membrane
C2U39_05135	COG0439	Biotin carboxylase
C2U39_05140	COG0511	ligase activity, forming carbon-carbon bonds
C2U39_05145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U39_05150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U39_05170	COG3381	protein complex oligomerization
C2U39_05185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U39_05195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U39_05200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U39_05200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U39_05215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U39_05220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U39_05225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U39_05230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U39_05235	COG4172	Belongs to the ABC transporter superfamily
C2U39_05255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U39_05260	COG0142	geranyltranstransferase activity
C2U39_05265	COG1722	exodeoxyribonuclease VII activity
C2U39_05270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U39_05275	COG1360	Flagellar Motor Protein
C2U39_05280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U39_05290	COG1534	Rna-binding protein
C2U39_05295	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U39_05300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U39_05305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U39_05310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U39_05315	COG0149	triose-phosphate isomerase activity
C2U39_05320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U39_05335	COG0779	Required for maturation of 30S ribosomal subunits
C2U39_05340	COG0195	Participates in both transcription termination and antitermination
C2U39_05345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U39_05350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U39_05355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U39_05360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U39_05365	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U39_05370	COG2211	Major facilitator Superfamily
C2U39_05375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U39_05380	COG1422	Protein of unknown function (DUF1090)
C2U39_05385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U39_05405	COG0312	modulator of DNA gyrase
C2U39_05410	COG0312	modulator of DNA gyrase
C2U39_05415	COG0716	FMN binding
C2U39_05420	COG4974	Belongs to the 'phage' integrase family
C2U39_05425	COG1970	mechanosensitive ion channel activity
C2U39_05435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U39_05440	COG0789	Transcriptional regulator
C2U39_05455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U39_05465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U39_05470	COG0321	lipoyl(octanoyl) transferase activity
C2U39_05475	COG2921	Belongs to the UPF0250 family
C2U39_05480	COG1686	Belongs to the peptidase S11 family
C2U39_05485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U39_05490	COG2951	lytic endotransglycosylase activity
C2U39_05495	COG0772	Belongs to the SEDS family
C2U39_05500	COG0768	penicillin binding
C2U39_05505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U39_05510	COG0799	negative regulation of ribosome biogenesis
C2U39_05515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U39_05530	COG0495	leucyl-tRNA aminoacylation
C2U39_05535	COG2888	peptidyl-tyrosine sulfation
C2U39_05540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U39_05545	COG4535	Mg2 and Co2 transporter CorC
C2U39_05550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U39_05555	COG1702	phosphate starvation-inducible protein PhoH
C2U39_05560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U39_05565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U39_05570	COG1335	isochorismatase
C2U39_05585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U39_05600	COG2199	diguanylate cyclase activity
C2U39_05610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U39_05625	COG1464	Belongs to the NlpA lipoprotein family
C2U39_05630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U39_05635	COG2011	ABC-type metal ion transport system permease component
C2U39_05640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U39_05650	COG0516	GMP reductase activity
C2U39_05655	COG4067	protein conserved in archaea
C2U39_05655	COG0189	ligase activity
C2U39_05665	COG0745	RESPONSE REGULATOR receiver
C2U39_05675	COG0300	oxidoreductase activity
C2U39_05695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U39_05700	COG3214	Protein conserved in bacteria
C2U39_05715	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U39_05720	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U39_05725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U39_05730	COG1053	succinate dehydrogenase
C2U39_05740	COG0584	glycerophosphoryl diester phosphodiesterase
C2U39_05745	COG1511	domain protein
C2U39_05745	COG3264	Mechanosensitive ion channel
C2U39_05755	COG0739	heme binding
C2U39_05765	COG3121	Chaperone
C2U39_05775	COG3121	Chaperone
C2U39_05790	COG0583	DNA-binding transcription factor activity
C2U39_05805	COG0583	DNA-binding transcription factor activity
C2U39_05810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U39_05840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U39_05845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U39_05855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U39_05860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U39_05865	COG0546	phosphoglycolate phosphatase activity
C2U39_05870	COG0180	Tryptophanyl-tRNA synthetase
C2U39_05885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U39_05895	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_05910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U39_05935	COG0471	metal ion transport
C2U39_05935	COG0490	domain, Protein
C2U39_05990	COG0732	type I restriction modification DNA specificity domain
C2U39_06000	COG1196	nuclear chromosome segregation
C2U39_06005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U39_06040	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U39_06045	COG0542	response to heat
C2U39_06080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U39_06145	COG0582	viral genome integration into host DNA
C2U39_06150	COG0012	GTP binding
C2U39_06155	COG0193	aminoacyl-tRNA hydrolase activity
C2U39_06160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U39_06170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U39_06175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U39_06180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U39_06185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U39_06190	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U39_06200	COG2912	Transglutaminase-like superfamily
C2U39_06205	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U39_06210	COG1301	dicarboxylic acid transport
C2U39_06220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U39_06235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U39_06240	COG1115	amino acid carrier protein
C2U39_06265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U39_06270	COG1678	Uncharacterized ACR, COG1678
C2U39_06275	COG0189	ligase activity
C2U39_06280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U39_06290	COG3091	SprT-like family
C2U39_06300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U39_06330	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U39_06335	COG0739	heme binding
C2U39_06340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U39_06350	COG1881	PFAM PEBP family protein
C2U39_06360	COG0583	DNA-binding transcription factor activity
C2U39_06370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U39_06380	COG0583	DNA-binding transcription factor activity
C2U39_06385	COG1028	Short-chain dehydrogenase reductase Sdr
C2U39_06390	COG0616	signal peptide processing
C2U39_06395	COG3724	N-succinylarginine dihydrolase activity
C2U39_06400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U39_06410	COG0840	transmembrane signaling receptor activity
C2U39_06420	COG2971	BadF BadG BcrA BcrD
C2U39_06430	COG4608	Belongs to the ABC transporter superfamily
C2U39_06435	COG0444	Belongs to the ABC transporter superfamily
C2U39_06440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U39_06455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U39_06465	COG0640	Transcriptional regulator
C2U39_06470	COG0798	PFAM Bile acid sodium symporter
C2U39_06475	COG1393	Belongs to the ArsC family
C2U39_06490	COG1677	Flagellar hook-basal body complex protein FliE
C2U39_06500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U39_06550	COG1987	bacterial-type flagellum assembly
C2U39_06555	COG1684	flagellar biosynthetic protein fliR
C2U39_06565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U39_06575	COG0455	bacterial-type flagellum organization
C2U39_06590	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U39_06595	COG0643	Histidine kinase
C2U39_06595	COG2198	Histidine kinase
C2U39_06600	COG2201	protein-glutamate methylesterase activity
C2U39_06605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U39_06610	COG1360	Flagellar Motor Protein
C2U39_06615	COG1192	Involved in chromosome partitioning
C2U39_06625	COG0835	chemotaxis
C2U39_06640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U39_06645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U39_06650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U39_06655	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U39_06660	COG1138	Cytochrome C-type biogenesis protein
C2U39_06665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U39_06675	COG0457	Tetratricopeptide repeat
C2U39_06690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U39_06695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U39_06695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U39_06710	COG0259	pyridoxamine-phosphate oxidase activity
C2U39_06740	COG3153	acetyltransferase
C2U39_06810	COG4735	regulation of single-species biofilm formation
C2U39_06840	COG0582	viral genome integration into host DNA
C2U39_06850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U39_06855	COG2867	negative regulation of translational initiation
C2U39_06865	COG0702	epimerase
C2U39_06870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U39_06875	COG1454	alcohol dehydrogenase
C2U39_06880	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U39_06890	COG1957	nucleoside hydrolase
C2U39_06915	COG1280	lysine exporter protein (LysE YggA)
C2U39_06925	COG3263	regulation of cellular component size
C2U39_06935	COG1876	peptidase activity
C2U39_06940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U39_06945	COG1393	Belongs to the ArsC family
C2U39_06960	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U39_06965	COG1473	amidohydrolase
C2U39_06975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U39_06980	COG0017	Asparaginyl-tRNA synthetase
C2U39_07000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U39_07005	COG0156	8-amino-7-oxononanoate synthase activity
C2U39_07010	COG1073	alpha beta
C2U39_07010	COG2226	methyltransferase
C2U39_07015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U39_07020	COG0501	Belongs to the peptidase M48B family
C2U39_07025	COG0633	Ferredoxin
C2U39_07025	COG3217	Mosc domain protein beta barrel domain protein
C2U39_07025	COG0633	Ferredoxin
C2U39_07025	COG3217	Mosc domain protein beta barrel domain protein
C2U39_07035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U39_07035	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U39_07035	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U39_07035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U39_07050	COG0534	Mate efflux family protein
C2U39_07075	COG1454	alcohol dehydrogenase
C2U39_07085	COG1309	transcriptional regulator
C2U39_07100	COG0791	NLP P60 protein
C2U39_07105	COG0583	DNA-binding transcription factor activity
C2U39_07125	COG0500	methyltransferase
C2U39_07130	COG4106	trans-aconitate 2-methyltransferase activity
C2U39_07135	COG1801	Protein of unknown function DUF72
C2U39_07145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U39_07150	COG0217	transcriptional regulatory protein
C2U39_07155	COG2194	sulfuric ester hydrolase activity
C2U39_07160	COG1940	carbohydrate kinase activity
C2U39_07160	COG1846	Transcriptional regulator
C2U39_07165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U39_07170	COG0363	glucosamine-6-phosphate deaminase activity
C2U39_07175	COG1263	PTS System
C2U39_07175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U39_07175	COG2190	(PTS) system
C2U39_07185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U39_07190	COG0735	belongs to the Fur family
C2U39_07200	COG0716	FMN binding
C2U39_07215	COG0596	Alpha beta hydrolase
C2U39_07220	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U39_07225	COG0033	Phosphoglucomutase
C2U39_07235	COG1846	Transcriptional regulator
C2U39_07240	COG2951	lytic endotransglycosylase activity
C2U39_07245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U39_07260	COG4134	Bacterial extracellular solute-binding protein
C2U39_07270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U39_07280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U39_07290	COG0729	surface antigen
C2U39_07295	COG2911	Protein conserved in bacteria
C2U39_07315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U39_07330	COG0741	lytic transglycosylase activity
C2U39_07345	COG1607	acyl-coa hydrolase
C2U39_07355	COG3021	interspecies interaction between organisms
C2U39_07360	COG0741	lytic transglycosylase activity
C2U39_07360	COG1388	LysM domain
C2U39_07365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U39_07370	COG2226	methyltransferase
C2U39_07375	COG0328	RNA-DNA hybrid ribonuclease activity
C2U39_07380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U39_07390	COG0784	Response regulator, receiver
C2U39_07390	COG3437	response regulator, receiver
C2U39_07395	COG1960	acyl-CoA dehydrogenase activity
C2U39_07400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U39_07405	COG0121	glutamine amidotransferase
C2U39_07415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U39_07425	COG2205	protein histidine kinase activity
C2U39_07425	COG0784	Response regulator, receiver
C2U39_07440	COG2197	response regulator
C2U39_07445	COG3850	Histidine kinase
C2U39_07450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U39_07455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U39_07455	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U39_07465	COG0243	molybdopterin cofactor binding
C2U39_07470	COG0437	4 iron, 4 sulfur cluster binding
C2U39_07475	COG0348	domain, Protein
C2U39_07485	COG3005	denitrification pathway
C2U39_07490	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U39_07495	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U39_07500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U39_07505	COG0314	molybdopterin synthase activity
C2U39_07520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U39_07525	COG2267	carboxylic ester hydrolase activity
C2U39_07540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U39_07550	COG0302	gtp cyclohydrolase
C2U39_07555	COG0840	transmembrane signaling receptor activity
C2U39_07580	COG0583	DNA-binding transcription factor activity
C2U39_07610	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U39_07620	COG1166	arginine decarboxylase activity
C2U39_07645	COG1403	HNH endonuclease
C2U39_07660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U39_07665	COG1187	pseudouridine synthase activity
C2U39_07670	COG2807	transmembrane transport
C2U39_07680	COG0583	DNA-binding transcription factor activity
C2U39_07700	COG2979	Protein of unknown function (DUF533)
C2U39_07710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U39_07715	COG1271	oxidase subunit
C2U39_07720	COG1294	oxidase, subunit
C2U39_07730	COG2814	Major facilitator Superfamily
C2U39_07735	COG0656	L-ascorbic acid biosynthetic process
C2U39_07755	COG0583	DNA-binding transcription factor activity
C2U39_07760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U39_07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U39_07770	COG2271	Major facilitator Superfamily
C2U39_07775	COG1349	DNA-binding transcription factor activity
C2U39_07785	COG0584	glycerophosphoryl diester phosphodiesterase
C2U39_07790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U39_07795	COG0287	Prephenate dehydrogenase
C2U39_07795	COG1605	Chorismate mutase
C2U39_07805	COG3085	chromosome segregation
C2U39_07810	COG4574	serine-type endopeptidase inhibitor activity
C2U39_07830	COG1770	oligopeptidase
C2U39_07835	COG4771	TonB-dependent receptor
C2U39_07840	COG3083	sulfuric ester hydrolase activity
C2U39_07845	COG3082	Protein of unknown function (DUF1414)
C2U39_07850	COG3081	Nucleoid-associated protein
C2U39_07860	COG1175	transmembrane transport
C2U39_07870	COG3842	ATPase activity
C2U39_07880	COG0596	Alpha beta hydrolase
C2U39_07895	COG0425	Belongs to the sulfur carrier protein TusA family
C2U39_07900	COG4783	chaperone-mediated protein folding
C2U39_07910	COG1393	Belongs to the ArsC family
C2U39_07935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_07940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U39_07945	COG2431	L-lysine efflux transmembrane transporter activity
C2U39_07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_07960	COG4215	(ABC) transporter
C2U39_07965	COG4160	amino acid transport
C2U39_07975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U39_07985	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U39_08000	COG1566	PFAM secretion protein HlyD family protein
C2U39_08010	COG0628	permease
C2U39_08015	COG2373	Large extracellular alpha-helical protein
C2U39_08020	COG4953	penicillin-binding protein 1C
C2U39_08030	COG0301	tRNA thio-modification
C2U39_08030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U39_08050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U39_08085	COG2089	acid synthase
C2U39_08100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U39_08105	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2U39_08115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U39_08120	COG1086	Polysaccharide biosynthesis protein
C2U39_08125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U39_08135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U39_08150	COG0840	transmembrane signaling receptor activity
C2U39_08155	COG0346	lactoylglutathione lyase activity
C2U39_08160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U39_08170	COG4659	FMN binding
C2U39_08175	COG4658	electron transport chain
C2U39_08185	COG2878	Part of a membrane complex involved in electron transport
C2U39_08190	COG4657	Part of a membrane complex involved in electron transport
C2U39_08195	COG0697	spore germination
C2U39_08215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U39_08220	COG1288	antiporter activity
C2U39_08225	COG0436	Aminotransferase
C2U39_08235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U39_08240	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U39_08245	COG1061	Type III restriction enzyme res subunit
C2U39_08250	COG1566	PFAM secretion protein HlyD family protein
C2U39_08260	COG3264	Mechanosensitive ion channel
C2U39_08260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U39_08265	COG1966	Carbon starvation protein
C2U39_08270	COG3279	Response regulator of the LytR AlgR family
C2U39_08275	COG3275	phosphorelay sensor kinase activity
C2U39_08285	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_08285	COG1454	alcohol dehydrogenase
C2U39_08290	COG2095	MarC family integral membrane protein
C2U39_08300	COG0601	transmembrane transport
C2U39_08305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U39_08310	COG0444	Belongs to the ABC transporter superfamily
C2U39_08320	COG0861	Integral membrane protein TerC family
C2U39_08325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U39_08335	COG1301	dicarboxylic acid transport
C2U39_08355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U39_08370	COG0537	adenosine 5'-monophosphoramidase activity
C2U39_08405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U39_08410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U39_08425	COG2354	Protein conserved in bacteria
C2U39_08430	COG1164	Oligoendopeptidase f
C2U39_08435	COG1164	Oligoendopeptidase f
C2U39_08445	COG1252	NADH dehydrogenase
C2U39_08455	COG0393	Putative heavy-metal-binding
C2U39_08460	COG1368	sulfuric ester hydrolase activity
C2U39_08470	COG0527	aspartate kinase activity
C2U39_08475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U39_08475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U39_08480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U39_08505	COG0583	DNA-binding transcription factor activity
C2U39_08510	COG1620	l-lactate permease
C2U39_08515	COG0247	lactate metabolic process
C2U39_08520	COG1139	Iron-sulfur cluster binding protein
C2U39_08545	COG1278	Cold shock
C2U39_08560	COG1136	(ABC) transporter
C2U39_08580	COG2814	Major facilitator Superfamily
C2U39_08605	COG0672	)-iron permease
C2U39_08640	COG2308	Evidence 4 Homologs of previously reported genes of
C2U39_08650	COG0300	oxidoreductase activity
C2U39_08680	COG0659	secondary active sulfate transmembrane transporter activity
C2U39_08730	COG3039	Transposase
C2U39_08745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U39_08755	COG0714	Associated with various cellular activities
C2U39_08760	COG3318	Belongs to the UPF0149 family
C2U39_08760	COG3012	SEC-C Motif Domain Protein
C2U39_08770	COG3039	Transposase
C2U39_08795	COG3415	Transposase
C2U39_08795	COG2801	Transposase and inactivated derivatives
C2U39_08890	COG3501	Rhs element vgr protein
C2U39_08910	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2U39_08915	COG0437	4 iron, 4 sulfur cluster binding
C2U39_08920	COG5557	Pfam Polysulphide reductase, NrfD
C2U39_08925	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2U39_08930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U39_08935	COG1773	rubredoxin
C2U39_08945	COG0601	transmembrane transport
C2U39_08950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U39_08955	COG0444	Belongs to the ABC transporter superfamily
C2U39_08960	COG3842	ATPase activity
C2U39_08965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2U39_08970	COG0375	protein maturation
C2U39_08975	COG0309	Hydrogenase expression formation protein (HypE)
C2U39_08985	COG0298	carbon dioxide binding
C2U39_08990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2U39_09000	COG3158	transport of potassium into the cell
C2U39_09025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U39_09030	COG0326	Molecular chaperone. Has ATPase activity
C2U39_09035	COG0563	adenylate kinase activity
C2U39_09040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U39_09045	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U39_09050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U39_09055	COG0840	transmembrane signaling receptor activity
C2U39_09070	COG3300	MHYT domain
C2U39_09070	COG5001	Diguanylate cyclase
C2U39_09095	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U39_09100	COG3433	isochorismatase activity
C2U39_09100	COG1535	isochorismatase
C2U39_09105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U39_09110	COG1028	Short-chain dehydrogenase reductase Sdr
C2U39_09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U39_09135	COG1120	ATPase activity
C2U39_09140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U39_09145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U39_09170	COG0598	Magnesium transport protein CorA
C2U39_09190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U39_09195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U39_09200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U39_09205	COG0861	Integral membrane protein TerC family
C2U39_09220	COG1022	Amp-dependent synthetase and ligase
C2U39_09225	COG0295	cytidine deaminase activity
C2U39_09230	COG1346	cytolysis
C2U39_09235	COG1380	Effector of murein hydrolase LrgA
C2U39_09240	COG3345	alpha-galactosidase
C2U39_09250	COG2925	Exonuclease
C2U39_09285	COG2801	Transposase and inactivated derivatives
C2U39_09295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U39_09300	COG0254	rRNA binding
C2U39_09315	COG1451	nucleotide metabolic process
C2U39_09330	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U39_09340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U39_09340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U39_09345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U39_09365	COG2009	succinate dehydrogenase
C2U39_09370	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U39_09385	COG0567	Dehydrogenase, E1 component
C2U39_09390	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U39_09395	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U39_09400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U39_09410	COG2983	Belongs to the UPF0260 family
C2U39_09415	COG1882	Formate acetyltransferase
C2U39_09420	COG2116	formate transmembrane transporter activity
C2U39_09425	COG1944	ATP diphosphatase activity
C2U39_09435	COG2076	Multidrug Resistance protein
C2U39_09440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U39_09445	COG1278	Cold shock
C2U39_09450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U39_09455	COG0542	response to heat
C2U39_09460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U39_09465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U39_09470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U39_09475	COG3134	Outer membrane lipoprotein
C2U39_09480	COG3706	GGDEF domain
C2U39_09485	COG0492	ferredoxin-NADP+ reductase activity
C2U39_09490	COG0686	Belongs to the AlaDH PNT family
C2U39_09500	COG0531	amino acid
C2U39_09500	COG1674	ftsk spoiiie
C2U39_09505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U39_09510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U39_09515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U39_09520	COG1286	toxin biosynthetic process
C2U39_09525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U39_09530	COG2723	6-phospho-beta-galactosidase activity
C2U39_09535	COG1263	PTS System
C2U39_09535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U39_09540	COG1609	Transcriptional regulator
C2U39_09550	COG4172	Belongs to the ABC transporter superfamily
C2U39_09560	COG4171	peptide transport system, permease
C2U39_09565	COG4168	peptide transport system, permease
C2U39_09575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U39_09580	COG1842	Phage shock protein A
C2U39_09595	COG3106	COG3106 Predicted ATPase
C2U39_09600	COG3768	UPF0283 membrane protein
C2U39_09610	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U39_09630	COG2885	chlorophyll binding
C2U39_09640	COG1570	exodeoxyribonuclease VII activity
C2U39_09665	COG1874	Beta-galactosidase
C2U39_09665	COG0366	Alpha amylase catalytic
C2U39_09675	COG0516	GMP reductase activity
C2U39_09675	COG0517	IMP dehydrogenase activity
C2U39_09680	COG0519	Catalyzes the synthesis of GMP from XMP
C2U39_09680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U39_09730	COG1846	Transcriptional regulator
C2U39_09740	COG0500	methyltransferase
C2U39_09750	COG2062	phosphohistidine phosphatase, SixA
C2U39_09760	COG0697	spore germination
C2U39_09770	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U39_09775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U39_09785	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U39_09790	COG1136	(ABC) transporter
C2U39_09795	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U39_09800	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U39_09815	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U39_09820	COG0740	serine-type endopeptidase activity
C2U39_09825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U39_09830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U39_09835	COG0776	regulation of translation
C2U39_09840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U39_09845	COG0488	(ABC) transporter
C2U39_09850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U39_09855	COG3162	membrane
C2U39_09870	COG1024	Enoyl-CoA hydratase
C2U39_09875	COG1115	amino acid carrier protein
C2U39_09885	COG3228	Belongs to the MtfA family
C2U39_09890	COG1584	GPR1 FUN34 yaaH family protein
C2U39_09915	COG1024	Enoyl-CoA hydratase
C2U39_09920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U39_09925	COG1960	acyl-CoA dehydrogenase activity
C2U39_09935	COG1960	acyl-CoA dehydrogenase activity
C2U39_09940	COG1024	Enoyl-CoA hydratase
C2U39_09945	COG1024	Enoyl-CoA hydratase
C2U39_09955	COG1028	Short-chain dehydrogenase reductase Sdr
C2U39_09965	COG0730	response to heat
C2U39_09980	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U39_09985	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U39_09990	COG1129	ABC transporter
C2U39_09995	COG1879	ABC-type sugar transport system periplasmic component
C2U39_10000	COG0583	DNA-binding transcription factor activity
C2U39_10010	COG0583	DNA-binding transcription factor activity
C2U39_10015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U39_10020	COG0243	molybdopterin cofactor binding
C2U39_10025	COG0745	RESPONSE REGULATOR receiver
C2U39_10025	COG3706	GGDEF domain
C2U39_10030	COG0583	DNA-binding transcription factor activity
C2U39_10035	COG2723	6-phospho-beta-galactosidase activity
C2U39_10045	COG0583	DNA-binding transcription factor activity
C2U39_10060	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U39_10065	COG0673	inositol 2-dehydrogenase activity
C2U39_10070	COG0583	DNA-binding transcription factor activity
C2U39_10080	COG1560	Kdo2-lipid A biosynthetic process
C2U39_10085	COG1560	Kdo2-lipid A biosynthetic process
C2U39_10100	COG0417	DNA replication proofreading
C2U39_10130	COG0534	Mate efflux family protein
C2U39_10140	COG0307	riboflavin synthase, alpha
C2U39_10185	COG4691	Plasmid stability protein
C2U39_10240	COG3316	Transposase and inactivated derivatives
C2U39_10290	COG3316	Transposase and inactivated derivatives
C2U39_10305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U39_10310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U39_10320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U39_10345	COG2996	Protein conserved in bacteria
C2U39_10365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U39_10375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U39_10380	COG2894	cell division
C2U39_10385	COG0850	regulation of cytokinetic process
C2U39_10390	COG3100	YcgL domain-containing protein
C2U39_10395	COG2951	lytic endotransglycosylase activity
C2U39_10400	COG1760	l-serine dehydratase
C2U39_10410	COG1760	l-serine dehydratase
C2U39_10415	COG3123	guanosine phosphorylase activity
C2U39_10420	COG1301	dicarboxylic acid transport
C2U39_10435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U39_10440	COG2067	long-chain fatty acid transport protein
C2U39_10445	COG2067	long-chain fatty acid transport protein
C2U39_10455	COG1595	DNA-templated transcription, initiation
C2U39_10485	COG0714	Associated with various cellular activities
C2U39_10490	COG0183	Belongs to the thiolase family
C2U39_10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U39_10495	COG1024	Enoyl-CoA hydratase
C2U39_10505	COG4681	YaeQ
C2U39_10525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U39_10540	COG3134	Outer membrane lipoprotein
C2U39_10545	COG0318	PFAM AMP-dependent synthetase and ligase
C2U39_10550	COG2378	regulation of single-species biofilm formation
C2U39_10560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U39_10560	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U39_10565	COG0107	imidazoleglycerol-phosphate synthase activity
C2U39_10570	COG0784	Response regulator, receiver
C2U39_10570	COG2198	Histidine kinase
C2U39_10570	COG2205	protein histidine kinase activity
C2U39_10580	COG3437	response regulator, receiver
C2U39_10585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U39_10590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U39_10595	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U39_10595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U39_10600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U39_10605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U39_10610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U39_10620	COG1199	ATP-dependent helicase activity
C2U39_10625	COG1214	PFAM Peptidase M22, glycoprotease
C2U39_10635	COG0596	Alpha beta hydrolase
C2U39_10640	COG0318	PFAM AMP-dependent synthetase and ligase
C2U39_10655	COG0697	spore germination
C2U39_10665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U39_10670	COG2832	Protein of unknown function (DUF454)
C2U39_10675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U39_10685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U39_10695	COG3039	Transposase
C2U39_10720	COG0583	DNA-binding transcription factor activity
C2U39_10740	COG2197	response regulator
C2U39_10750	COG1643	Atp-dependent helicase
C2U39_10760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U39_10770	COG3437	response regulator, receiver
C2U39_10775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U39_10780	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U39_10785	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U39_10800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U39_10805	COG0840	transmembrane signaling receptor activity
C2U39_10810	COG1254	Belongs to the acylphosphatase family
C2U39_10820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U39_10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U39_10825	COG0489	protein tyrosine kinase activity
C2U39_10830	COG0572	uridine kinase
C2U39_10835	COG0717	Belongs to the dCTP deaminase family
C2U39_10840	COG0306	phosphate transporter
C2U39_10845	COG4644	lycopene metabolic process
C2U39_10855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U39_10860	COG3041	Addiction module toxin RelE StbE family
C2U39_10880	COG1530	ribonuclease E activity
C2U39_10885	COG0564	pseudouridine synthase activity
C2U39_10900	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U39_10905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U39_10910	COG0416	fatty acid biosynthetic process
C2U39_10915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U39_10925	COG1028	Short-chain dehydrogenase reductase Sdr
C2U39_10930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U39_10935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U39_10940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U39_10945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U39_10950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U39_10955	COG0470	DNA polymerase III
C2U39_10960	COG0084	hydrolase, TatD family'
C2U39_10975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U39_10975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U39_10980	COG3008	intermembrane lipid transfer
C2U39_10985	COG2995	paraquat-inducible protein a
C2U39_10995	COG3141	response to X-ray
C2U39_11010	COG1067	ATP-dependent peptidase activity
C2U39_11015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U39_11040	COG0116	Belongs to the methyltransferase superfamily
C2U39_11040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U39_11050	COG0167	dihydroorotate dehydrogenase activity
C2U39_11055	COG2902	Dehydrogenase
C2U39_11065	COG0308	aminopeptidase N
C2U39_11075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U39_11080	COG1956	GAF domain-containing protein
C2U39_11090	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U39_11105	COG2010	Cytochrome c
C2U39_11115	COG2217	Heavy metal translocating P-type atpase
C2U39_11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U39_11135	COG0589	response to stress
C2U39_11140	COG0037	tRNA processing
C2U39_11155	COG0625	glutathione transferase activity
C2U39_11160	COG1869	D-ribose catabolic process
C2U39_11165	COG1129	ABC transporter
C2U39_11170	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U39_11175	COG1879	ABC-type sugar transport system periplasmic component
C2U39_11180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U39_11185	COG1609	Transcriptional regulator
C2U39_11190	COG5001	Diguanylate cyclase
C2U39_11190	COG3300	MHYT domain
C2U39_11200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U39_11220	COG0776	regulation of translation
C2U39_11225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U39_11225	COG0072	phenylalanine-tRNA ligase activity
C2U39_11230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U39_11235	COG4974	Belongs to the 'phage' integrase family
C2U39_11250	COG3385	transposase activity
C2U39_11335	COG4695	Portal protein
C2U39_11440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2U39_11470	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C2U39_11475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U39_11480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U39_11485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U39_11490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U39_11515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U39_11525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U39_11530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U39_11535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U39_11540	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U39_11545	COG3313	Fe-S protein
C2U39_11550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U39_11550	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U39_11550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U39_11555	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U39_11560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_11560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_11565	COG1609	Transcriptional regulator
C2U39_11570	COG0814	amino acid
C2U39_11580	COG5654	RES domain protein
C2U39_11585	COG0513	Belongs to the DEAD box helicase family
C2U39_11595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U39_11600	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U39_11605	COG2840	Smr protein MutS2
C2U39_11640	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U39_11650	COG1280	lysine exporter protein (LysE YggA)
C2U39_11680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U39_11685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2U39_11710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U39_11730	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U39_11740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U39_11745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U39_11755	COG0205	6-phosphofructokinase activity
C2U39_11765	COG1473	amidohydrolase
C2U39_11770	COG1011	Hydrolase
C2U39_11775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U39_11815	COG3593	DNA synthesis involved in DNA repair
C2U39_11830	COG0583	DNA-binding transcription factor activity
C2U39_11835	COG0730	response to heat
C2U39_11845	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U39_11855	COG0386	Belongs to the glutathione peroxidase family
C2U39_11860	COG0513	Belongs to the DEAD box helicase family
C2U39_11875	COG1742	UPF0060 membrane protein
C2U39_11900	COG2329	Antibiotic biosynthesis monooxygenase
C2U39_11905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U39_11925	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U39_11935	COG2501	S4 domain
C2U39_11950	COG1132	(ABC) transporter
C2U39_11955	COG1132	(ABC) transporter
C2U39_11965	COG3118	belongs to the thioredoxin family
C2U39_11970	COG0471	metal ion transport
C2U39_11980	COG0058	SHG alpha-glucan phosphorylase activity
C2U39_12010	COG0814	amino acid
C2U39_12015	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U39_12020	COG0514	ATP-dependent DNA helicase (RecQ)
C2U39_12025	COG2766	serine protein kinase
C2U39_12030	COG2718	Belongs to the UPF0229 family
C2U39_12035	COG2719	SpoVR family
C2U39_12040	COG2186	Transcriptional regulator
C2U39_12045	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U39_12050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U39_12055	COG0586	Pfam SNARE associated Golgi protein
C2U39_12065	COG0556	nucleotide-excision repair
C2U39_12080	COG0569	domain protein
C2U39_12080	COG2985	domain, Protein
C2U39_12085	COG0741	lytic transglycosylase activity
C2U39_12085	COG1196	nuclear chromosome segregation
C2U39_12085	COG0739	heme binding
C2U39_12090	COG3181	Tripartite tricarboxylate transporter family receptor
C2U39_12105	COG4565	transcriptional regulatory protein
C2U39_12110	COG3290	protein histidine kinase activity
C2U39_12115	COG1940	carbohydrate kinase activity
C2U39_12115	COG1846	Transcriptional regulator
C2U39_12120	COG0840	transmembrane signaling receptor activity
C2U39_12125	COG3012	SEC-C Motif Domain Protein
C2U39_12130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U39_12135	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U39_12140	COG0247	lactate metabolic process
C2U39_12160	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U39_12165	COG0437	4 iron, 4 sulfur cluster binding
C2U39_12170	COG3301	Polysulphide reductase, NrfD
C2U39_12175	COG1138	Cytochrome C-type biogenesis protein
C2U39_12180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U39_12185	COG4235	cytochrome complex assembly
C2U39_12185	COG3088	subunit of a heme lyase
C2U39_12200	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U39_12205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U39_12210	COG0516	GMP reductase activity
C2U39_12210	COG0517	IMP dehydrogenase activity
C2U39_12220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U39_12225	COG0583	DNA-binding transcription factor activity
C2U39_12235	COG4774	siderophore transport
C2U39_12240	COG3706	GGDEF domain
C2U39_12245	COG2200	EAL domain
C2U39_12250	COG1917	Cupin 2, conserved barrel domain protein
C2U39_12250	COG4977	sequence-specific DNA binding
C2U39_12255	COG0583	DNA-binding transcription factor activity
C2U39_12260	COG2910	NAD(P)H-binding
C2U39_12275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U39_12295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U39_12300	COG1349	DNA-binding transcription factor activity
C2U39_12335	COG1435	thymidine kinase activity
C2U39_12340	COG1757	Na H antiporter
C2U39_12345	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U39_12350	COG2096	Adenosyltransferase
C2U39_12355	COG3530	Putative quorum-sensing-regulated virulence factor
C2U39_12360	COG0602	queuosine metabolic process
C2U39_12365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U39_12385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U39_12395	COG0776	regulation of translation
C2U39_12400	COG0539	negative regulation of cytoplasmic translation
C2U39_12405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U39_12410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U39_12440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U39_12445	COG5001	Diguanylate cyclase
C2U39_12445	COG3300	MHYT domain
C2U39_12455	COG0583	DNA-binding transcription factor activity
C2U39_12460	COG0745	RESPONSE REGULATOR receiver
C2U39_12485	COG4989	oxidoreductase activity
C2U39_12490	COG0724	RNA recognition motif
C2U39_12500	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U39_12510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U39_12525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U39_12530	COG1360	Flagellar Motor Protein
C2U39_12535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U39_12540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U39_12560	COG1034	ATP synthesis coupled electron transport
C2U39_12565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U39_12570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U39_12575	COG0839	Belongs to the complex I subunit 6 family
C2U39_12580	COG0713	ATP synthesis coupled electron transport
C2U39_12590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U39_12595	COG1007	ATP synthesis coupled electron transport
C2U39_12600	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U39_12600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U39_12605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U39_12610	COG1645	bacterial-type flagellum-dependent swarming motility
C2U39_12615	COG1160	GTP binding
C2U39_12620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U39_12625	COG2976	Protein conserved in bacteria
C2U39_12630	COG0124	histidyl-tRNA synthetase
C2U39_12635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2U39_12640	COG1426	Protein conserved in bacteria
C2U39_12650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U39_12655	COG0105	UTP biosynthetic process
C2U39_12660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U39_12670	COG0633	Ferredoxin
C2U39_12675	COG0443	Heat shock 70 kDa protein
C2U39_12680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U39_12690	COG0822	iron-sulfur transferase activity
C2U39_12695	COG1104	cysteine desulfurase activity
C2U39_12730	COG2897	thiosulfate sulfurtransferase activity
C2U39_12735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U39_12740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U39_12745	COG1862	Preprotein translocase
C2U39_12750	COG0343	queuine tRNA-ribosyltransferase activity
C2U39_12755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U39_12760	COG0517	IMP dehydrogenase activity
C2U39_12765	COG0450	alkyl hydroperoxide reductase
C2U39_12770	COG3634	alkyl hydroperoxide reductase activity
C2U39_12800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U39_12800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U39_12805	COG0509	glycine decarboxylation via glycine cleavage system
C2U39_12810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U39_12815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U39_12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U39_12840	COG2814	Major facilitator Superfamily
C2U39_12850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U39_12855	COG0601	transmembrane transport
C2U39_12865	COG0625	glutathione transferase activity
C2U39_12870	COG0625	glutathione transferase activity
C2U39_12880	COG0483	inositol monophosphate 1-phosphatase activity
C2U39_12895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U39_12900	COG2056	Na+-H+ antiporter family
C2U39_12905	COG2814	Major facilitator Superfamily
C2U39_12910	COG0583	DNA-binding transcription factor activity
C2U39_12915	COG5001	Diguanylate cyclase
C2U39_12930	COG2050	protein possibly involved in aromatic compounds catabolism
C2U39_12940	COG0277	FAD linked oxidase domain protein
C2U39_12940	COG0247	lactate metabolic process
C2U39_12950	COG1253	flavin adenine dinucleotide binding
C2U39_12955	COG1902	pentaerythritol trinitrate reductase activity
C2U39_12965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U39_12970	COG0647	UMP catabolic process
C2U39_12980	COG0367	asparagine synthase
C2U39_12995	COG0625	glutathione transferase activity
C2U39_13005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U39_13020	COG0564	pseudouridine synthase activity
C2U39_13025	COG5001	Diguanylate cyclase
C2U39_13035	COG0318	PFAM AMP-dependent synthetase and ligase
C2U39_13080	COG2855	membrane
C2U39_13090	COG2814	Major facilitator Superfamily
C2U39_13095	COG3246	L-lysine catabolic process to acetate
C2U39_13100	COG2175	clavaminate synthase activity
C2U39_13110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U39_13150	COG0670	Belongs to the BI1 family
C2U39_13155	COG1289	transmembrane transporter activity
C2U39_13160	COG2920	part of a sulfur-relay system
C2U39_13165	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U39_13170	COG0285	dihydrofolate synthase activity
C2U39_13175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U39_13180	COG0101	tRNA pseudouridine synthase activity
C2U39_13190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U39_13195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U39_13205	COG1464	Belongs to the NlpA lipoprotein family
C2U39_13225	COG1119	ATPase activity
C2U39_13230	COG2199	diguanylate cyclase activity
C2U39_13230	COG2203	Gaf domain
C2U39_13245	COG0574	Belongs to the PEP-utilizing enzyme family
C2U39_13245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U39_13250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U39_13260	COG1113	amino acid transport
C2U39_13335	COG1242	4 iron, 4 sulfur cluster binding
C2U39_13340	COG0070	glutamate synthase
C2U39_13340	COG0067	glutamate synthase
C2U39_13340	COG0069	glutamate synthase activity
C2U39_13345	COG0493	'glutamate synthase
C2U39_13365	COG4104	PAAR repeat-containing protein
C2U39_13375	COG0513	Belongs to the DEAD box helicase family
C2U39_13415	COG3706	GGDEF domain
C2U39_13420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U39_13425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U39_13430	COG0505	Belongs to the CarA family
C2U39_13435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U39_13445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U39_13450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U39_13455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U39_13460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U39_13465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U39_13470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U39_13475	COG4139	cobalamin transport
C2U39_13500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2U39_13510	COG0023	Translation Initiation Factor
C2U39_13515	COG2119	membrane
C2U39_13550	COG2199	diguanylate cyclase activity
C2U39_13550	COG2203	Gaf domain
C2U39_13575	COG2801	Transposase and inactivated derivatives
C2U39_13585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U39_13595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U39_13600	COG2261	transglycosylase associated protein
C2U39_13605	COG1309	transcriptional regulator
C2U39_13610	COG0604	alcohol dehydrogenase
C2U39_13630	COG2801	Transposase and inactivated derivatives
C2U39_13640	COG2314	TM2 domain
C2U39_13770	COG4584	PFAM Integrase catalytic
C2U39_13775	COG1484	DNA-dependent DNA replication
C2U39_13810	COG2314	TM2 domain
C2U39_13830	COG2801	Transposase and inactivated derivatives
C2U39_13925	COG0322	excinuclease ABC activity
C2U39_13930	COG2197	response regulator
C2U39_13935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U39_13940	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U39_13945	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U39_13950	COG1132	(ABC) transporter
C2U39_13955	COG0658	competence protein
C2U39_13955	COG2333	competence protein COMEC
C2U39_13970	COG0433	COG0433 Predicted ATPase
C2U39_13975	COG1448	Aminotransferase
C2U39_13990	COG1199	ATP-dependent helicase activity
C2U39_14000	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U39_14005	COG0477	Major facilitator Superfamily
C2U39_14010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U39_14015	COG1785	Belongs to the alkaline phosphatase family
C2U39_14035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U39_14040	COG3706	GGDEF domain
C2U39_14045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_14050	COG0765	amino acid transport
C2U39_14055	COG1126	abc transporter atp-binding protein
C2U39_14070	COG0531	amino acid
C2U39_14085	COG1253	flavin adenine dinucleotide binding
C2U39_14090	COG0704	Plays a role in the regulation of phosphate uptake
C2U39_14100	COG0581	inorganic phosphate transmembrane transporter activity
C2U39_14105	COG0573	inorganic phosphate transmembrane transporter activity
C2U39_14110	COG0590	tRNA wobble adenosine to inosine editing
C2U39_14125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U39_14145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U39_14150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U39_14155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U39_14160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U39_14165	COG2204	response regulator
C2U39_14170	COG3852	Histidine kinase
C2U39_14175	COG2204	response regulator
C2U39_14185	COG2716	regulation of RNA biosynthetic process
C2U39_14190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U39_14195	COG0248	Ppx GppA phosphatase
C2U39_14200	COG2239	Acts as a magnesium transporter
C2U39_14215	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U39_14215	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U39_14220	COG1706	bacterial-type flagellum-dependent cell motility
C2U39_14225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U39_14230	COG4786	Flagellar basal body rod
C2U39_14240	COG1749	Flagellar hook protein flgE
C2U39_14250	COG1558	bacterial-type flagellum-dependent cell motility
C2U39_14255	COG1815	bacterial-type flagellum-dependent cell motility
C2U39_14260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U39_14265	COG0784	Response regulator, receiver
C2U39_14265	COG0835	chemotaxis
C2U39_14270	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U39_14285	COG0622	Phosphoesterase
C2U39_14290	COG4166	transmembrane transport
C2U39_14300	COG1187	pseudouridine synthase activity
C2U39_14305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U39_14315	COG0697	spore germination
C2U39_14320	COG4166	transmembrane transport
C2U39_14345	COG1278	Cold shock
C2U39_14385	COG3132	Protein of unknown function, DUF480
C2U39_14420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U39_14425	COG1215	transferase activity, transferring glycosyl groups
C2U39_14435	COG0438	transferase activity, transferring glycosyl groups
C2U39_14460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U39_14465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U39_14470	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2U39_14480	COG0745	RESPONSE REGULATOR receiver
C2U39_14495	COG1737	Transcriptional regulator
C2U39_14500	COG0469	pyruvate kinase activity
C2U39_14510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_14515	COG1960	acyl-CoA dehydrogenase activity
C2U39_14525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U39_14540	COG1538	Outer membrane efflux protein
C2U39_14545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_14550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_14555	COG1309	transcriptional regulator
C2U39_14570	COG1946	Acyl-CoA thioesterase
C2U39_14590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U39_14600	COG0009	L-threonylcarbamoyladenylate synthase
C2U39_14605	COG0613	PHP domain protein
C2U39_14610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U39_14615	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U39_14615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U39_14620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U39_14625	COG0134	indole-3-glycerol-phosphate synthase activity
C2U39_14625	COG0135	phosphoribosylanthranilate isomerase activity
C2U39_14630	COG0133	tryptophan synthase activity
C2U39_14635	COG0159	tryptophan synthase activity
C2U39_14735	COG4521	taurine ABC transporter
C2U39_14740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U39_14745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U39_14750	COG2175	clavaminate synthase activity
C2U39_14755	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U39_14760	COG2814	Major facilitator Superfamily
C2U39_14770	COG0109	protoheme IX farnesyltransferase activity
C2U39_14775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U39_14780	COG1845	cytochrome c oxidase, subunit III
C2U39_14785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U39_14790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U39_14795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U39_14800	COG0583	DNA-binding transcription factor activity
C2U39_14820	COG1846	Transcriptional regulator
C2U39_14835	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U39_14860	COG0708	Exodeoxyribonuclease III
C2U39_14875	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_14890	COG0095	Lipoate-protein ligase
C2U39_14910	COG2391	methyltransferase activity
C2U39_14930	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U39_14940	COG1285	pathogenesis
C2U39_14970	COG0484	heat shock protein binding
C2U39_14975	COG0443	Heat shock 70 kDa protein
C2U39_14980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U39_14985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U39_14990	COG3706	GGDEF domain
C2U39_14995	COG0497	DNA recombination
C2U39_15005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_15010	COG1136	(ABC) transporter
C2U39_15010	COG0577	efflux transmembrane transporter activity
C2U39_15015	COG1538	Outer membrane efflux protein
C2U39_15020	COG2375	cellular response to nickel ion
C2U39_15025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U39_15030	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U39_15035	COG0583	DNA-binding transcription factor activity
C2U39_15040	COG3048	D-serine ammonia-lyase activity
C2U39_15050	COG0538	isocitrate dehydrogenase activity
C2U39_15080	COG0456	acetyltransferase
C2U39_15085	COG1187	pseudouridine synthase activity
C2U39_15095	COG0482	sulfurtransferase activity
C2U39_15100	COG2915	High frequency lysogenization protein hflD homolog
C2U39_15105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U39_15110	COG2850	peptidyl-arginine hydroxylation
C2U39_15120	COG3264	Mechanosensitive ion channel
C2U39_15120	COG1196	nuclear chromosome segregation
C2U39_15150	COG0281	malic enzyme
C2U39_15155	COG0746	molybdenum cofactor guanylyltransferase activity
C2U39_15160	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U39_15165	COG1289	transmembrane transporter activity
C2U39_15170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U39_15200	COG3220	belongs to the UPF0276 family
C2U39_15210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U39_15225	COG3039	Transposase
C2U39_15230	COG0456	acetyltransferase
C2U39_15240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U39_15255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U39_15260	COG0083	homoserine kinase activity
C2U39_15275	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U39_15280	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U39_15295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U39_15305	COG0745	RESPONSE REGULATOR receiver
C2U39_15330	COG1192	Involved in chromosome partitioning
C2U39_15550	COG2003	Belongs to the UPF0758 family
C2U39_15640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U39_15680	COG0583	DNA-binding transcription factor activity
C2U39_15685	COG1396	sequence-specific DNA binding
C2U39_15695	COG0582	viral genome integration into host DNA
C2U39_15705	COG4988	ABC transporter
C2U39_15710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U39_15730	COG1720	tRNA m6t6A37 methyltransferase activity
C2U39_15745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U39_15750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U39_15755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U39_15765	COG2190	(PTS) system
C2U39_15770	COG3038	cytochrome b561
C2U39_15780	COG0420	3'-5' exonuclease activity
C2U39_15785	COG1247	-acetyltransferase
C2U39_15790	COG2974	May be involved in recombination
C2U39_15800	COG0405	Gamma-glutamyltransferase
C2U39_15805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U39_15805	COG4651	solute:proton antiporter activity
C2U39_15840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U39_15845	COG1396	sequence-specific DNA binding
C2U39_15845	COG1917	Cupin 2, conserved barrel domain protein
C2U39_15850	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_15860	COG0531	amino acid
C2U39_15865	COG0531	amino acid
C2U39_15875	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U39_15885	COG3384	dioxygenase
C2U39_15890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_15890	COG2205	protein histidine kinase activity
C2U39_15925	COG1388	LysM domain
C2U39_15925	COG1376	ErfK ybiS ycfS ynhG family protein
C2U39_15940	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U39_15945	COG0791	NLP P60 protein
C2U39_15955	COG3118	belongs to the thioredoxin family
C2U39_15965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U39_15970	COG0788	formyltetrahydrofolate deformylase activity
C2U39_15995	COG0739	heme binding
C2U39_15995	COG1196	nuclear chromosome segregation
C2U39_15995	COG0741	lytic transglycosylase activity
C2U39_16000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U39_16005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U39_16010	COG0673	inositol 2-dehydrogenase activity
C2U39_16050	COG1032	radical SAM domain protein
C2U39_16055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_16065	COG3706	GGDEF domain
C2U39_16070	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U39_16075	COG0733	neurotransmitter:sodium symporter activity
C2U39_16105	COG0281	malic enzyme
C2U39_16110	COG2207	Transcriptional regulator
C2U39_16115	COG0534	Mate efflux family protein
C2U39_16125	COG0745	RESPONSE REGULATOR receiver
C2U39_16125	COG3706	GGDEF domain
C2U39_16130	COG2233	PERMEase
C2U39_16135	COG0095	Lipoate-protein ligase
C2U39_16140	COG1115	amino acid carrier protein
C2U39_16145	COG0019	diaminopimelate decarboxylase activity
C2U39_16155	COG0678	peroxiredoxin activity
C2U39_16160	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U39_16170	COG1126	abc transporter atp-binding protein
C2U39_16175	COG0765	amino acid transport
C2U39_16180	COG4597	amino acid ABC transporter
C2U39_16185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_16200	COG1131	(ABC) transporter
C2U39_16205	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U39_16215	COG3142	Participates in the control of copper homeostasis
C2U39_16220	COG1940	carbohydrate kinase activity
C2U39_16230	COG4783	chaperone-mediated protein folding
C2U39_16240	COG5002	protein histidine kinase activity
C2U39_16245	COG0745	RESPONSE REGULATOR receiver
C2U39_16250	COG0346	lactoylglutathione lyase activity
C2U39_16255	COG3706	GGDEF domain
C2U39_16260	COG3284	Transcriptional regulator
C2U39_16265	COG1012	belongs to the aldehyde dehydrogenase family
C2U39_16275	COG0697	spore germination
C2U39_16280	COG0667	Aldo Keto reductase
C2U39_16295	COG3290	protein histidine kinase activity
C2U39_16305	COG1566	PFAM secretion protein HlyD family protein
C2U39_16330	COG0602	queuosine metabolic process
C2U39_16335	COG1328	CTP reductase activity
C2U39_16345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U39_16350	COG3115	cell septum assembly
C2U39_16365	COG2860	membrane
C2U39_16375	COG3108	Peptidase M15
C2U39_16380	COG2989	Protein conserved in bacteria
C2U39_16395	COG0463	Glycosyl transferase, family 2
C2U39_16410	COG0366	Alpha amylase catalytic
C2U39_16455	COG3706	GGDEF domain
C2U39_16460	COG0037	tRNA processing
C2U39_16465	COG3590	peptidase
C2U39_16485	COG0531	amino acid
C2U39_16490	COG0814	amino acid
C2U39_16505	COG0825	malonyl-CoA metabolic process
C2U39_16515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U39_16520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U39_16525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U39_16530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U39_16535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U39_16550	COG0750	zinc metalloprotease
C2U39_16555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U39_16560	COG0575	Belongs to the CDS family
C2U39_16570	COG0233	cytoplasmic translational termination
C2U39_16575	COG0528	UMP kinase activity
C2U39_16580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U39_16585	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U39_16590	COG0024	Methionine aminopeptidase
C2U39_16595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U39_16600	COG2171	N-acyltransferase activity
C2U39_16610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U39_16610	COG1263	PTS System
C2U39_16625	COG4580	involved in the transport of maltose and maltodextrins
C2U39_16635	COG0564	pseudouridine synthase activity
C2U39_16640	COG3098	single-species biofilm formation
C2U39_16665	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U39_16675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U39_16675	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U39_16685	COG3706	GGDEF domain
C2U39_16690	COG1611	Belongs to the LOG family
C2U39_16695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U39_16700	COG0473	3-isopropylmalate dehydrogenase activity
C2U39_16710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U39_16725	COG0583	DNA-binding transcription factor activity
C2U39_16730	COG0840	transmembrane signaling receptor activity
C2U39_16735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U39_16750	COG1477	protein flavinylation
C2U39_16755	COG2871	sodium ion transport
C2U39_16760	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U39_16765	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U39_16770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U39_16775	COG1805	sodium ion transport
C2U39_16780	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U39_16785	COG0271	Belongs to the BolA IbaG family
C2U39_16790	COG2813	Specifically methylates the guanine in position
C2U39_16800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U39_16810	COG2211	Major facilitator Superfamily
C2U39_16815	COG3248	Nucleoside-binding outer membrane protein
C2U39_16820	COG1666	GTP binding
C2U39_16825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U39_16875	COG3501	Rhs element vgr protein
C2U39_16885	COG2771	luxR family
C2U39_16890	COG0659	secondary active sulfate transmembrane transporter activity
C2U39_16895	COG5000	phosphorelay sensor kinase activity
C2U39_16895	COG5002	protein histidine kinase activity
C2U39_16900	COG0745	RESPONSE REGULATOR receiver
C2U39_16905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_16910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_16930	COG1609	Transcriptional regulator
C2U39_16935	COG2182	Extracellular solute-binding protein
C2U39_16940	COG0840	transmembrane signaling receptor activity
C2U39_16955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U39_16960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U39_16960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U39_16965	COG2723	6-phospho-beta-galactosidase activity
C2U39_16970	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U39_16990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U39_17000	COG1151	hydroxylamine reductase activity
C2U39_17005	COG0783	Belongs to the Dps family
C2U39_17030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U39_17045	COG4221	oxidoreductase activity
C2U39_17055	COG0415	Belongs to the DNA photolyase family
C2U39_17060	COG0789	Transcriptional regulator
C2U39_17065	COG3272	Protein of unknown function (DUF1722)
C2U39_17090	COG0077	Prephenate dehydratase
C2U39_17090	COG1605	Chorismate mutase
C2U39_17120	COG5377	YqaJ viral recombinase family
C2U39_17165	COG2003	Belongs to the UPF0758 family
C2U39_17225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U39_17265	COG2133	pyrroloquinoline quinone binding
C2U39_17275	COG1349	DNA-binding transcription factor activity
C2U39_17280	COG2084	Dehydrogenase
C2U39_17285	COG3395	kinase activity
C2U39_17290	COG0235	Class ii aldolase
C2U39_17295	COG3622	Belongs to the hyi family
C2U39_17300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U39_17305	COG2610	gluconate transmembrane transporter activity
C2U39_17335	COG0300	oxidoreductase activity
C2U39_17360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U39_17380	COG3813	Protein conserved in bacteria
C2U39_17390	COG0826	peptidase U32
C2U39_17395	COG1280	lysine exporter protein (LysE YggA)
C2U39_17475	COG1566	PFAM secretion protein HlyD family protein
C2U39_17485	COG0114	fumarate hydratase activity
C2U39_17495	COG0506	proline dehydrogenase activity
C2U39_17495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U39_17495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U39_17500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U39_17505	COG0305	Participates in initiation and elongation during chromosome replication
C2U39_17545	COG2204	response regulator
C2U39_17550	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U39_17560	COG2900	Belongs to the SlyX family
C2U39_17565	COG1047	Peptidyl-prolyl cis-trans
C2U39_17570	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U39_17580	COG0835	chemotaxis
C2U39_17580	COG0784	Response regulator, receiver
C2U39_17585	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U39_17590	COG4251	negative regulation of phosphorylation
C2U39_17590	COG5001	Diguanylate cyclase
C2U39_17590	COG3706	GGDEF domain
C2U39_17590	COG2203	Gaf domain
C2U39_17595	COG3089	Belongs to the UPF0270 family
C2U39_17600	COG3954	Phosphoribulokinase
C2U39_17615	COG1765	OsmC-like protein
C2U39_17620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U39_17625	COG2226	methyltransferase
C2U39_17635	COG2202	Pas domain
C2U39_17635	COG2205	protein histidine kinase activity
C2U39_17640	COG2814	Major facilitator Superfamily
C2U39_17665	COG0748	coenzyme F420 binding
C2U39_17670	COG3721	Heme iron utilization protein
C2U39_17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U39_17705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U39_17715	COG0463	Glycosyl transferase, family 2
C2U39_17720	COG0741	lytic transglycosylase activity
C2U39_17725	COG0488	(ABC) transporter
C2U39_17735	COG2252	PERMEase
C2U39_17740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U39_17745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U39_17750	COG3178	'Phosphotransferase
C2U39_17755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U39_17765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U39_17770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U39_17780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U39_17790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U39_17795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U39_17805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U39_17810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U39_17815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U39_17820	COG0142	geranyltranstransferase activity
C2U39_17825	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U39_17830	COG0330	HflC and HflK could
C2U39_17835	COG0330	HflC and HflK could
C2U39_17840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U39_17845	COG1923	regulation of RNA biosynthetic process
C2U39_17850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U39_17855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U39_17865	COG0802	atpase or kinase
C2U39_17870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U39_17870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U39_17890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U39_17895	COG2011	ABC-type metal ion transport system permease component
C2U39_17900	COG1464	Belongs to the NlpA lipoprotein family
C2U39_17920	COG2205	protein histidine kinase activity
C2U39_17920	COG0784	Response regulator, receiver
C2U39_17935	COG5002	protein histidine kinase activity
C2U39_17935	COG2198	Histidine kinase
C2U39_17935	COG0784	Response regulator, receiver
C2U39_17955	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U39_17970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U39_17975	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U39_17980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U39_17985	COG2716	regulation of RNA biosynthetic process
C2U39_17990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U39_17995	COG3013	Belongs to the UPF0304 family
C2U39_18000	COG3092	negative regulation of chromosome organization
C2U39_18005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U39_18010	COG0280	phosphate acetyltransferase
C2U39_18010	COG0857	belongs to the CobB CobQ family
C2U39_18015	COG0440	acetolactate synthase activity
C2U39_18020	COG0028	Belongs to the TPP enzyme family
C2U39_18035	COG0671	phosphoesterase, PA-phosphatase related
C2U39_18045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U39_18050	COG0473	3-isopropylmalate dehydrogenase activity
C2U39_18055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U39_18060	COG0066	3-isopropylmalate dehydratase activity
C2U39_18075	COG4143	(ABC) transporter
C2U39_18080	COG1178	ABC-type Fe3 transport system permease component
C2U39_18085	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U39_18090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U39_18100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U39_18155	COG2205	protein histidine kinase activity
C2U39_18160	COG0745	RESPONSE REGULATOR receiver
C2U39_18165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_18170	COG0577	efflux transmembrane transporter activity
C2U39_18170	COG1136	(ABC) transporter
C2U39_18180	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U39_18215	COG2203	Gaf domain
C2U39_18215	COG2199	diguanylate cyclase activity
C2U39_18225	COG0513	Belongs to the DEAD box helicase family
C2U39_18235	COG2207	Transcriptional regulator
C2U39_18235	COG1917	Cupin 2, conserved barrel domain protein
C2U39_18260	COG3385	transposase activity
C2U39_18270	COG2801	Transposase and inactivated derivatives
C2U39_18285	COG0154	amidase activity
C2U39_18290	COG2957	Belongs to the agmatine deiminase family
C2U39_18315	COG1902	pentaerythritol trinitrate reductase activity
C2U39_18320	COG0456	acetyltransferase
C2U39_18330	COG0456	acetyltransferase
C2U39_18345	COG0745	RESPONSE REGULATOR receiver
C2U39_18345	COG3706	GGDEF domain
C2U39_18350	COG5002	protein histidine kinase activity
C2U39_18350	COG5001	Diguanylate cyclase
C2U39_18355	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2U39_18370	COG0456	acetyltransferase
C2U39_18380	COG1022	Amp-dependent synthetase and ligase
C2U39_18390	COG1794	racemase activity, acting on amino acids and derivatives
C2U39_18405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U39_18420	COG0733	neurotransmitter:sodium symporter activity
C2U39_18425	COG0733	neurotransmitter:sodium symporter activity
C2U39_18440	COG0561	phosphatase activity
C2U39_18455	COG1522	sequence-specific DNA binding
C2U39_18470	COG1846	Transcriptional regulator
C2U39_18475	COG2130	NADP-dependent
C2U39_18480	COG1051	belongs to the nudix hydrolase family
C2U39_18505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U39_18510	COG1640	4-alpha-glucanotransferase
C2U39_18515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U39_18525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U39_18530	COG0840	transmembrane signaling receptor activity
C2U39_18605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U39_18610	COG2885	chlorophyll binding
C2U39_18615	COG0823	Involved in the tonB-independent uptake of proteins
C2U39_18630	COG0811	peptide transport
C2U39_18635	COG0824	Thioesterase
C2U39_18640	COG3790	cyd operon protein YbgE
C2U39_18645	COG4890	Cyd operon protein YbgT
C2U39_18650	COG1294	oxidase, subunit
C2U39_18655	COG1271	oxidase subunit
C2U39_18665	COG2255	four-way junction helicase activity
C2U39_18670	COG0632	four-way junction helicase activity
C2U39_18675	COG0840	transmembrane signaling receptor activity
C2U39_18680	COG0442	prolyl-tRNA aminoacylation
C2U39_18685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U39_18690	COG4221	oxidoreductase activity
C2U39_18705	COG1024	Enoyl-CoA hydratase
C2U39_18720	COG4166	transmembrane transport
C2U39_18730	COG0840	transmembrane signaling receptor activity
C2U39_18735	COG0513	Belongs to the DEAD box helicase family
C2U39_18770	COG3118	belongs to the thioredoxin family
C2U39_18770	COG0457	Tetratricopeptide repeat
C2U39_18780	COG1215	transferase activity, transferring glycosyl groups
C2U39_18800	COG2194	sulfuric ester hydrolase activity
C2U39_18805	COG1448	Aminotransferase
C2U39_18820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U39_18825	COG1328	CTP reductase activity
C2U39_18850	COG0840	transmembrane signaling receptor activity
C2U39_18855	COG3397	chitin binding
C2U39_18860	COG0583	DNA-binding transcription factor activity
C2U39_18865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U39_18870	COG4208	sulfate ABC transporter
C2U39_18875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U39_18885	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U39_18920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U39_18925	COG0564	pseudouridine synthase activity
C2U39_18945	COG0459	protein refolding
C2U39_18950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U39_18960	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U39_18965	COG1027	Aspartate ammonia-lyase
C2U39_18970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U39_18975	COG2918	glutathione biosynthetic process
C2U39_18980	COG0612	Peptidase, M16
C2U39_18985	COG1238	metal cluster binding
C2U39_19025	COG0359	binds to the 23S rRNA
C2U39_19030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U39_19035	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U39_19040	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U39_19050	COG2153	protein acetylation
C2U39_19060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U39_19065	COG0557	exoribonuclease II activity
C2U39_19070	COG3706	GGDEF domain
C2U39_19075	COG1854	S-ribosylhomocysteine lyase activity
C2U39_19090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U39_19090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U39_19140	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U39_19150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U39_19155	COG1047	Peptidyl-prolyl cis-trans
C2U39_19160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U39_19165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U39_19170	COG0196	riboflavin kinase activity
C2U39_19175	COG0728	peptidoglycan biosynthetic process
C2U39_19180	COG0268	Binds directly to 16S ribosomal RNA
C2U39_19185	COG0640	Transcriptional regulator
C2U39_19190	COG0583	DNA-binding transcription factor activity
C2U39_19200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U39_19205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U39_19210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U39_19220	COG1051	belongs to the nudix hydrolase family
C2U39_19225	COG3066	DNA modification
C2U39_19235	COG0335	large ribosomal subunit rRNA binding
C2U39_19240	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U39_19245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U39_19250	COG0228	four-way junction DNA binding
C2U39_19255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U39_19260	COG4137	Cytochrome C assembly protein
C2U39_19265	COG4536	flavin adenine dinucleotide binding
C2U39_19275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U39_19275	COG1017	nitric oxide dioxygenase activity
C2U39_19280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U39_19290	COG0039	L-malate dehydrogenase activity
C2U39_19295	COG4160	amino acid transport
C2U39_19300	COG4215	(ABC) transporter
C2U39_19305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_19310	COG1126	abc transporter atp-binding protein
C2U39_19315	COG1438	arginine binding
C2U39_19320	COG2837	iron assimilation
C2U39_19325	COG3842	ATPase activity
C2U39_19340	COG0347	Belongs to the P(II) protein family
C2U39_19355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U39_19360	COG0583	DNA-binding transcription factor activity
C2U39_19375	COG1929	Belongs to the glycerate kinase type-1 family
C2U39_19380	COG2610	gluconate transmembrane transporter activity
C2U39_19385	COG3835	regulator
C2U39_19390	COG3112	Uncharacterised protein family (UPF0231)
C2U39_19410	COG1872	DUF167
C2U39_19415	COG0762	integral membrane protein
C2U39_19420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U39_19425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U39_19440	COG3022	response to hydroperoxide
C2U39_19445	COG0513	Belongs to the DEAD box helicase family
C2U39_19450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U39_19470	COG0735	belongs to the Fur family
C2U39_19475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U39_19490	COG0776	regulation of translation
C2U39_19495	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U39_19505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U39_19520	COG0560	Phosphoserine phosphatase
C2U39_19530	COG3447	MASE1 domain protein
C2U39_19530	COG5001	Diguanylate cyclase
C2U39_19530	COG5002	protein histidine kinase activity
C2U39_19545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U39_19550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U39_19555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U39_19565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U39_19570	COG0084	hydrolase, TatD family'
C2U39_19575	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U39_19585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U39_19590	COG0004	ammonium transporteR
C2U39_19610	COG0795	lipopolysaccharide-transporting ATPase activity
C2U39_19615	COG0795	lipopolysaccharide-transporting ATPase activity
C2U39_19620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U39_19625	COG2927	DNA polymerase III (CHI subunit)
C2U39_19630	COG0525	valine-tRNA ligase activity
C2U39_19635	COG1253	flavin adenine dinucleotide binding
C2U39_19640	COG0586	Pfam SNARE associated Golgi protein
C2U39_19645	COG1686	Belongs to the peptidase S11 family
C2U39_19680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U39_19685	COG0527	aspartate kinase activity
C2U39_19690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U39_19695	COG2137	regulation of response to DNA damage stimulus
C2U39_19700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U39_19705	COG1546	Belongs to the CinA family
C2U39_19715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U39_19735	COG3068	Protein conserved in bacteria
C2U39_19745	COG0739	heme binding
C2U39_19765	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U39_19770	COG1121	(ABC) transporter
C2U39_19775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U39_19780	COG0583	DNA-binding transcription factor activity
C2U39_19790	COG1573	uracil-dna glycosylase
C2U39_19795	COG2962	Rard protein
C2U39_19800	COG2827	Endonuclease containing a URI domain
C2U39_19815	COG1842	Phage shock protein A
C2U39_19820	COG0204	Acyl-transferase
C2U39_19840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U39_19850	COG0484	heat shock protein binding
C2U39_19920	COG3039	Transposase
C2U39_19945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U39_19950	COG1074	ATP-dependent DNA helicase activity
C2U39_19955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U39_19960	COG2259	Doxx family
C2U39_19965	COG1741	Belongs to the pirin family
C2U39_19975	COG0583	DNA-binding transcription factor activity
C2U39_20000	COG1175	transmembrane transport
C2U39_20010	COG3842	ATPase activity
C2U39_20020	COG0745	RESPONSE REGULATOR receiver
C2U39_20020	COG3706	GGDEF domain
C2U39_20040	COG0456	acetyltransferase
C2U39_20045	COG0753	catalase activity
C2U39_20065	COG0494	nUDIX hydrolase
C2U39_20070	COG0628	permease
C2U39_20080	COG2957	Belongs to the agmatine deiminase family
C2U39_20095	COG2957	Belongs to the agmatine deiminase family
C2U39_20100	COG0583	DNA-binding transcription factor activity
C2U39_20115	COG1461	Dihydroxyacetone kinase
C2U39_20120	COG2376	Dihydroxyacetone kinase
C2U39_20125	COG2252	PERMEase
C2U39_20130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U39_20160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U39_20165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U39_20170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U39_20175	COG0049	tRNA binding
C2U39_20180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U39_20185	COG2168	tRNA wobble position uridine thiolation
C2U39_20195	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U39_20200	COG0251	oxidation-reduction process
C2U39_20205	COG2964	Protein conserved in bacteria
C2U39_20210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U39_20215	COG0085	RNA polymerase activity
C2U39_20220	COG0222	ribosome binding
C2U39_20225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U39_20230	COG0081	regulation of translation
C2U39_20235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U39_20240	COG0250	Participates in transcription elongation, termination and antitermination
C2U39_20245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U39_20255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U39_20280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U39_20285	COG0569	domain protein
C2U39_20290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U39_20295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U39_20300	COG3005	denitrification pathway
C2U39_20305	COG0243	molybdopterin cofactor binding
C2U39_20315	COG2205	protein histidine kinase activity
C2U39_20320	COG0745	RESPONSE REGULATOR receiver
C2U39_20340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U39_20355	COG2204	response regulator
C2U39_20365	COG2205	protein histidine kinase activity
C2U39_20385	COG4109	DRTGG domain
C2U39_20395	COG1522	sequence-specific DNA binding
C2U39_20400	COG2502	aspartate--ammonia ligase
C2U39_20405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U39_20410	COG0542	response to heat
C2U39_20420	COG0564	pseudouridine synthase activity
C2U39_20425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U39_20430	COG3681	Belongs to the UPF0597 family
C2U39_20435	COG2964	Protein conserved in bacteria
C2U39_20440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U39_20445	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U39_20450	COG1979	alcohol dehydrogenase
C2U39_20455	COG2207	Transcriptional regulator
C2U39_20460	COG3040	lipid binding
C2U39_20485	COG0583	DNA-binding transcription factor activity
C2U39_20505	COG0540	Belongs to the ATCase OTCase family
C2U39_20510	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U39_20515	COG1438	arginine binding
C2U39_20520	COG1288	antiporter activity
C2U39_20525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U39_20565	COG3250	beta-galactosidase activity
C2U39_20570	COG1609	Transcriptional regulator
C2U39_20575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U39_20585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U39_20590	COG2017	converts alpha-aldose to the beta-anomer
C2U39_20595	COG0667	Aldo Keto reductase
C2U39_20600	COG1968	undecaprenyl-diphosphatase activity
C2U39_20605	COG3806	Anti-sigma factor
C2U39_20610	COG1595	DNA-templated transcription, initiation
C2U39_20630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U39_20635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U39_20640	COG0477	Major facilitator Superfamily
C2U39_20655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_20660	COG1131	(ABC) transporter
C2U39_20665	COG0842	Transport permease protein
C2U39_20670	COG0842	Transport permease protein
C2U39_20675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U39_20680	COG2146	nitrite reductase [NAD(P)H] activity
C2U39_20685	COG2116	formate transmembrane transporter activity
C2U39_20690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U39_20690	COG1648	precorrin-2 dehydrogenase activity
C2U39_20695	COG2239	Acts as a magnesium transporter
C2U39_20700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U39_20705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U39_20715	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U39_20725	COG0514	ATP-dependent DNA helicase (RecQ)
C2U39_20730	COG2050	protein possibly involved in aromatic compounds catabolism
C2U39_20745	COG2258	MOSC domain
C2U39_20750	COG1177	transmembrane transport
C2U39_20755	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U39_20760	COG3842	ATPase activity
C2U39_20780	COG0174	glutamine synthetase
C2U39_20785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U39_20800	COG3045	CreA protein
C2U39_20805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U39_20810	COG0443	Heat shock 70 kDa protein
C2U39_20825	COG0366	Alpha amylase catalytic
C2U39_20840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U39_20845	COG0745	RESPONSE REGULATOR receiver
C2U39_20855	COG2205	protein histidine kinase activity
C2U39_20865	COG0281	malic enzyme
C2U39_20870	COG0702	epimerase
C2U39_20875	COG0254	rRNA binding
C2U39_20880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U39_20885	COG1309	transcriptional regulator
C2U39_20905	COG0129	dihydroxy-acid dehydratase activity
C2U39_20910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U39_20915	COG3978	acetolactate synthase activity
C2U39_20930	COG0606	chelatase, subunit chli
C2U39_20935	COG0204	Acyl-transferase
C2U39_20940	COG0204	Acyl-transferase
C2U39_20945	COG1683	Conserved Protein
C2U39_20955	COG1335	isochorismatase
C2U39_20965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U39_20970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U39_20980	COG3084	Protein conserved in bacteria
C2U39_20985	COG5001	Diguanylate cyclase
C2U39_20985	COG4251	negative regulation of phosphorylation
C2U39_20985	COG3706	GGDEF domain
C2U39_20985	COG2203	Gaf domain
C2U39_21000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U39_21005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U39_21010	COG1561	YicC-like family, N-terminal region
C2U39_21020	COG1519	Transferase
C2U39_21025	COG0859	PFAM glycosyl transferase family 9
C2U39_21030	COG0463	Glycosyl transferase, family 2
C2U39_21035	COG0859	PFAM glycosyl transferase family 9
C2U39_21040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U39_21045	COG2990	Protein conserved in bacteria
C2U39_21050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U39_21060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U39_21065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U39_21070	COG2003	Belongs to the UPF0758 family
C2U39_21075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U39_21080	COG0756	dUTP diphosphatase activity
C2U39_21085	COG1309	transcriptional regulator
C2U39_21100	COG0668	transmembrane transport
C2U39_21110	COG0166	Belongs to the GPI family
C2U39_21115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U39_21120	COG0583	DNA-binding transcription factor activity
C2U39_21130	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U39_21130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U39_21130	COG1042	CoA-binding domain protein
C2U39_21155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U39_21160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U39_21160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U39_21165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U39_21170	COG3074	FtsZ-dependent cytokinesis
C2U39_21180	COG1045	serine acetyltransferase
C2U39_21190	COG0745	RESPONSE REGULATOR receiver
C2U39_21195	COG2205	protein histidine kinase activity
C2U39_21200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U39_21205	COG0534	Mate efflux family protein
C2U39_21220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U39_21225	COG2937	Belongs to the GPAT DAPAT family
C2U39_21230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U39_21235	COG3161	chorismate lyase activity
C2U39_21240	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U39_21260	COG1609	Transcriptional regulator
C2U39_21300	COG3307	-O-antigen
C2U39_21310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U39_21320	COG0156	8-amino-7-oxononanoate synthase activity
C2U39_21325	COG1063	alcohol dehydrogenase
C2U39_21345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U39_21350	COG2166	iron-sulfur cluster assembly
C2U39_21355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U39_21385	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U39_21390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U39_21395	COG1739	Uncharacterized protein family UPF0029
C2U39_21400	COG0006	proline dipeptidase activity
C2U39_21405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U39_21410	COG1024	Enoyl-CoA hydratase
C2U39_21410	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U39_21415	COG0183	Belongs to the thiolase family
C2U39_21420	COG0745	RESPONSE REGULATOR receiver
C2U39_21425	COG2205	protein histidine kinase activity
C2U39_21445	COG0425	Belongs to the sulfur carrier protein TusA family
C2U39_21450	COG0251	oxidation-reduction process
C2U39_21470	COG2885	chlorophyll binding
C2U39_21485	COG1335	isochorismatase
C2U39_21490	COG2818	Glycosylase
C2U39_21495	COG0752	glycyl-tRNA synthetase alpha subunit
C2U39_21500	COG0751	glycine-tRNA ligase activity
C2U39_21515	COG2203	Gaf domain
C2U39_21515	COG3706	GGDEF domain
C2U39_21515	COG5001	Diguanylate cyclase
C2U39_21515	COG4251	negative regulation of phosphorylation
C2U39_21530	COG0814	amino acid
C2U39_21535	COG0814	amino acid
C2U39_21560	COG0348	domain, Protein
C2U39_21570	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U39_21575	COG1773	rubredoxin
C2U39_21575	COG0426	domain, Protein
C2U39_21580	COG3604	Transcriptional regulator
C2U39_21585	COG1609	Transcriptional regulator
C2U39_21595	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U39_21625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U39_21640	COG2960	long-chain fatty acid transporting porin activity
C2U39_21650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U39_21660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U39_21665	COG3118	belongs to the thioredoxin family
C2U39_21670	COG0513	Belongs to the DEAD box helicase family
C2U39_21675	COG0248	Ppx GppA phosphatase
C2U39_21685	COG0742	ribosomal rna small subunit methyltransferase
C2U39_21695	COG0339	signal peptide processing
C2U39_21705	COG0084	hydrolase, TatD family'
C2U39_21710	COG0805	protein transport
C2U39_21715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U39_21720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U39_21725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U39_21730	COG3165	ubiquinone biosynthetic process from chorismate
C2U39_21740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U39_21745	COG0402	S-adenosylhomocysteine deaminase activity
C2U39_21785	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U39_21790	COG0848	biopolymer transport protein
C2U39_21795	COG0811	peptide transport
C2U39_21800	COG0811	peptide transport
C2U39_21810	COG2771	luxR family
C2U39_21815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U39_21820	COG1349	DNA-binding transcription factor activity
C2U39_21825	COG0745	RESPONSE REGULATOR receiver
C2U39_21830	COG2205	protein histidine kinase activity
C2U39_21840	COG4452	Inner membrane protein CreD
C2U39_21845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U39_21850	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U39_21855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U39_21860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U39_21865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U39_21870	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U39_21875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U39_21885	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U39_21895	COG1475	DNA binding
C2U39_21900	COG1192	Involved in chromosome partitioning
C2U39_21905	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U39_21910	COG0445	tRNA wobble uridine modification
C2U39_21915	COG0716	FMN binding
C2U39_21920	COG4774	siderophore transport
C2U39_21925	COG4615	Cyclic peptide transporter
C2U39_21930	COG1120	ATPase activity
C2U39_21935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U39_22005	COG0582	viral genome integration into host DNA
C2U39_22010	COG3550	peptidyl-serine autophosphorylation
C2U39_22065	COG1695	Transcriptional regulator
C2U39_22075	COG3316	Transposase and inactivated derivatives
C2U39_22100	COG3173	Aminoglycoside phosphotransferase
C2U39_22110	COG3316	Transposase and inactivated derivatives
C2U39_22185	COG4974	Belongs to the 'phage' integrase family
C2U39_22190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U39_22195	COG0706	membrane insertase activity
C2U39_22200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U39_22205	COG0594	ribonuclease P activity
C2U39_22210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U39_22230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U39_22235	COG0592	DNA-directed DNA polymerase activity
C2U39_22245	COG0187	DNA topoisomerase II activity
C2U39_22250	COG2207	Transcriptional regulator
C2U39_22255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U39_22265	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U39_22270	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U39_22275	COG3977	Valine--pyruvate aminotransferase
C2U39_22290	COG2814	Major facilitator Superfamily
C2U39_22295	COG0745	RESPONSE REGULATOR receiver
C2U39_22300	COG2205	protein histidine kinase activity
C2U39_22325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U39_22330	COG4191	Histidine kinase
C2U39_22330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U39_22335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U39_22340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U39_22350	COG1309	transcriptional regulator
C2U39_22380	COG0561	phosphatase activity
C2U39_22385	COG2267	carboxylic ester hydrolase activity
C2U39_22395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U39_22400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U39_22405	COG1758	RNA polymerase activity
C2U39_22420	COG0859	PFAM glycosyl transferase family 9
C2U39_22425	COG3642	lipopolysaccharide core region biosynthetic process
C2U39_22465	COG0589	response to stress
C2U39_22475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U39_22480	COG3706	GGDEF domain
C2U39_22485	COG1528	Iron-storage protein
C2U39_22495	COG2223	nitrite transmembrane transporter activity
C2U39_22500	COG1280	lysine exporter protein (LysE YggA)
C2U39_22525	COG3188	usher protein
C2U39_22560	COG3275	phosphorelay sensor kinase activity
C2U39_22565	COG3279	Response regulator of the LytR AlgR family
C2U39_22570	COG2223	nitrite transmembrane transporter activity
C2U39_22575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U39_22580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U39_22635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U39_22650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U39_22690	COG1192	Involved in chromosome partitioning
C2U39_22695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U39_22705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U39_22710	COG3041	Addiction module toxin RelE StbE family
C2U39_22715	COG3077	Addiction module antitoxin, RelB DinJ family
C2U39_22770	COG3385	transposase activity
C2U39_22870	COG2176	DNA-directed DNA polymerase activity
C2U39_22870	COG5002	protein histidine kinase activity
C2U39_22950	COG1192	Involved in chromosome partitioning
C2U39_22975	COG0625	glutathione transferase activity
C2U39_23150	COG0776	regulation of translation
C2U39_23220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U39_23275	COG0583	DNA-binding transcription factor activity
C2U39_23280	COG3041	Addiction module toxin RelE StbE family
C2U39_23285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U39_23375	COG1192	Involved in chromosome partitioning
C2U39_23465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U39_23555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U39_23580	COG5001	Diguanylate cyclase
C2U39_23615	COG0714	Associated with various cellular activities
C2U39_23625	COG0629	single-stranded DNA binding
C2U39_23675	COG0633	Ferredoxin
C2U39_23835	COG3344	reverse transcriptase
C2U39_23875	COG1357	PFAM Pentapeptide repeats (8 copies)
C2U39_23900	COG3316	Transposase and inactivated derivatives
C2U39_23910	COG3316	Transposase and inactivated derivatives
C2U39_23920	COG3173	Aminoglycoside phosphotransferase
C2U39_23925	COG3316	Transposase and inactivated derivatives
C2U39_23960	COG4644	lycopene metabolic process
C2U39_24005	COG4974	Belongs to the 'phage' integrase family
C2U39_24020	COG0659	secondary active sulfate transmembrane transporter activity
C2U39_24025	COG0589	response to stress
C2U39_24035	COG1484	DNA-dependent DNA replication
C2U39_24040	COG4584	PFAM Integrase catalytic