locus-tag	class	description
C2U40_00045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_00050	COG1459	type II secretion system
C2U40_00095	COG1077	Cell shape determining protein MreB Mrl
C2U40_00100	COG1792	Involved in formation and maintenance of cell shape
C2U40_00105	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U40_00110	COG0424	maF-like protein
C2U40_00115	COG1530	ribonuclease E activity
C2U40_00120	COG3164	Protein of unknown function
C2U40_00130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U40_00135	COG0312	modulator of DNA gyrase
C2U40_00150	COG0477	Major facilitator Superfamily
C2U40_00160	COG3437	response regulator, receiver
C2U40_00165	COG5002	protein histidine kinase activity
C2U40_00165	COG2205	protein histidine kinase activity
C2U40_00165	COG0784	Response regulator, receiver
C2U40_00170	COG2172	sigma factor antagonist activity
C2U40_00175	COG1366	Belongs to the anti-sigma-factor antagonist family
C2U40_00195	COG3700	Belongs to the class B bacterial acid phosphatase family
C2U40_00205	COG2321	neutral zinc metallopeptidase
C2U40_00215	COG1639	'signal transduction protein
C2U40_00245	COG0189	ligase activity
C2U40_00250	COG1114	Component of the transport system for branched-chain amino acids
C2U40_00260	COG0745	RESPONSE REGULATOR receiver
C2U40_00275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U40_00280	COG0352	thiamine-phosphate diphosphorylase activity
C2U40_00285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U40_00295	COG2022	thiamine diphosphate biosynthetic process
C2U40_00300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U40_00325	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C2U40_00345	COG3706	GGDEF domain
C2U40_00350	COG0814	amino acid
C2U40_00355	COG3932	Exopolysaccharide synthesis, ExoD
C2U40_00375	COG1733	regulation of RNA biosynthetic process
C2U40_00415	COG1494	fructose-1,6-bisphosphatase
C2U40_00430	COG2959	enzyme of heme biosynthesis
C2U40_00440	COG0181	hydroxymethylbilane synthase activity
C2U40_00445	COG3072	Adenylate cyclase
C2U40_00450	COG0400	carboxylic ester hydrolase activity
C2U40_00455	COG1965	Belongs to the frataxin family
C2U40_00460	COG0019	diaminopimelate decarboxylase activity
C2U40_00465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U40_00480	COG1011	Hydrolase
C2U40_00500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U40_00505	COG0561	phosphatase activity
C2U40_00520	COG0842	Transport permease protein
C2U40_00520	COG1129	ABC transporter
C2U40_00530	COG1058	Belongs to the CinA family
C2U40_00530	COG1546	Belongs to the CinA family
C2U40_00535	COG1418	mRNA catabolic process
C2U40_00540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U40_00550	COG1522	sequence-specific DNA binding
C2U40_00555	COG1368	sulfuric ester hydrolase activity
C2U40_00575	COG1285	pathogenesis
C2U40_00595	COG4221	oxidoreductase activity
C2U40_00615	COG1979	alcohol dehydrogenase
C2U40_00625	COG2873	o-acetylhomoserine
C2U40_00635	COG4533	DNA binding
C2U40_00650	COG5380	lipid catabolic process
C2U40_00655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U40_00675	COG2949	membrane
C2U40_00680	COG3291	Pkd domain containing protein
C2U40_00690	COG3539	Fimbrial protein
C2U40_00700	COG3188	usher protein
C2U40_00705	COG3121	Chaperone
C2U40_00710	COG3539	Fimbrial protein
C2U40_00725	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_00730	COG1441	menaquinone biosynthetic process
C2U40_00735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U40_00740	COG0596	Alpha beta hydrolase
C2U40_00745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U40_00750	COG1169	isochorismate synthase
C2U40_00755	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U40_00780	COG0513	Belongs to the DEAD box helicase family
C2U40_00785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_00790	COG1988	membrane-bound metal-dependent
C2U40_00805	COG1671	Belongs to the UPF0178 family
C2U40_00830	COG3263	regulation of cellular component size
C2U40_00835	COG3722	fumarate hydratase activity
C2U40_00840	COG0246	Mannitol dehydrogenase
C2U40_00845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_00845	COG2213	PTS system mannitol-specific
C2U40_00855	COG1309	transcriptional regulator
C2U40_00860	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U40_00870	COG3916	Acyl-homoserine-lactone synthase
C2U40_00875	COG2771	luxR family
C2U40_00890	COG3133	Outer membrane lipoprotein
C2U40_00895	COG0456	acetyltransferase
C2U40_00920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U40_00930	COG3031	protein transport across the cell outer membrane
C2U40_00940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_00945	COG1459	type II secretion system
C2U40_00950	COG2165	general secretion pathway protein
C2U40_00965	COG2165	general secretion pathway protein
C2U40_00970	COG4795	General secretion pathway protein
C2U40_00975	COG3156	type II secretion system protein K
C2U40_00985	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U40_01000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U40_01005	COG1011	Hydrolase
C2U40_01010	COG0494	nUDIX hydrolase
C2U40_01015	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U40_01020	COG0814	amino acid
C2U40_01025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_01030	COG2207	Transcriptional regulator
C2U40_01030	COG3708	Transcriptional regulator
C2U40_01040	COG0626	cystathionine gamma-synthase activity
C2U40_01045	COG0527	aspartate kinase activity
C2U40_01045	COG0460	homoserine dehydrogenase
C2U40_01050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U40_01060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U40_01065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U40_01075	COG0137	argininosuccinate synthase activity
C2U40_01080	COG0165	Argininosuccinate lyase
C2U40_01105	COG0110	maltose O-acetyltransferase activity
C2U40_01110	COG3174	membrane
C2U40_01115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U40_01125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U40_01130	COG4208	sulfate ABC transporter
C2U40_01135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U40_01140	COG0583	DNA-binding transcription factor activity
C2U40_01145	COG3397	chitin binding
C2U40_01150	COG0840	transmembrane signaling receptor activity
C2U40_01185	COG4946	Tricorn protease homolog
C2U40_01185	COG0793	Belongs to the peptidase S41A family
C2U40_01205	COG1328	CTP reductase activity
C2U40_01210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_01225	COG1448	Aminotransferase
C2U40_01265	COG0513	Belongs to the DEAD box helicase family
C2U40_01280	COG3568	Endonuclease Exonuclease Phosphatase
C2U40_01285	COG0840	transmembrane signaling receptor activity
C2U40_01300	COG3112	Uncharacterised protein family (UPF0231)
C2U40_01305	COG3835	regulator
C2U40_01310	COG2610	gluconate transmembrane transporter activity
C2U40_01315	COG1929	Belongs to the glycerate kinase type-1 family
C2U40_01330	COG0583	DNA-binding transcription factor activity
C2U40_01335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_01350	COG0347	Belongs to the P(II) protein family
C2U40_01355	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U40_01365	COG3842	ATPase activity
C2U40_01370	COG2837	iron assimilation
C2U40_01375	COG1438	arginine binding
C2U40_01380	COG1126	abc transporter atp-binding protein
C2U40_01385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_01390	COG4215	(ABC) transporter
C2U40_01395	COG4160	amino acid transport
C2U40_01400	COG0039	L-malate dehydrogenase activity
C2U40_01405	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U40_01410	COG1017	nitric oxide dioxygenase activity
C2U40_01410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_01420	COG4536	flavin adenine dinucleotide binding
C2U40_01425	COG4137	Cytochrome C assembly protein
C2U40_01430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U40_01435	COG0228	four-way junction DNA binding
C2U40_01440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U40_01445	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U40_01450	COG0335	large ribosomal subunit rRNA binding
C2U40_01460	COG3066	DNA modification
C2U40_01470	COG1051	belongs to the nudix hydrolase family
C2U40_01480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U40_01485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U40_01490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_01500	COG0583	DNA-binding transcription factor activity
C2U40_01505	COG0640	Transcriptional regulator
C2U40_01510	COG0268	Binds directly to 16S ribosomal RNA
C2U40_01515	COG0728	peptidoglycan biosynthetic process
C2U40_01520	COG0196	riboflavin kinase activity
C2U40_01525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U40_01530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U40_01535	COG1047	Peptidyl-prolyl cis-trans
C2U40_01540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U40_01600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U40_01600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U40_01615	COG1854	S-ribosylhomocysteine lyase activity
C2U40_01620	COG3706	GGDEF domain
C2U40_01625	COG0557	exoribonuclease II activity
C2U40_01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U40_01645	COG2153	protein acetylation
C2U40_01665	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U40_01670	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U40_01675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U40_01680	COG0359	binds to the 23S rRNA
C2U40_01685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_01710	COG1238	metal cluster binding
C2U40_01715	COG0612	Peptidase, M16
C2U40_01720	COG2918	glutathione biosynthetic process
C2U40_01730	COG1022	Amp-dependent synthetase and ligase
C2U40_01740	COG0456	acetyltransferase
C2U40_01750	COG0714	Associated with various cellular activities
C2U40_01765	COG0745	RESPONSE REGULATOR receiver
C2U40_01765	COG3706	GGDEF domain
C2U40_01775	COG3385	transposase activity
C2U40_01800	COG1902	pentaerythritol trinitrate reductase activity
C2U40_01810	COG2852	Protein conserved in bacteria
C2U40_01825	COG2957	Belongs to the agmatine deiminase family
C2U40_01830	COG0154	amidase activity
C2U40_01860	COG0513	Belongs to the DEAD box helicase family
C2U40_01895	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U40_01900	COG1858	cytochrome C peroxidase
C2U40_01925	COG2070	2-Nitropropane dioxygenase
C2U40_01960	COG2816	NAD+ diphosphatase activity
C2U40_01965	COG2205	protein histidine kinase activity
C2U40_01970	COG0745	RESPONSE REGULATOR receiver
C2U40_01975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_01980	COG1136	(ABC) transporter
C2U40_01980	COG0577	efflux transmembrane transporter activity
C2U40_01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_01990	COG1126	abc transporter atp-binding protein
C2U40_01995	COG0765	amino acid transport
C2U40_02000	COG0765	amino acid transport
C2U40_02005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U40_02010	COG1505	serine-type exopeptidase activity
C2U40_02030	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_02035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U40_02050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U40_02055	COG4991	sh3 domain protein
C2U40_02070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U40_02075	COG1940	carbohydrate kinase activity
C2U40_02080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U40_02085	COG0126	phosphoglycerate kinase activity
C2U40_02095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_02135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U40_02145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U40_02150	COG1595	DNA-templated transcription, initiation
C2U40_02155	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U40_02170	COG0481	GTPase activity
C2U40_02175	COG0681	Belongs to the peptidase S26 family
C2U40_02180	COG0571	ribonuclease III activity
C2U40_02190	COG1381	Involved in DNA repair and RecF pathway recombination
C2U40_02195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U40_02210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_02215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_02220	COG3716	PTS system mannose fructose sorbose family IID component
C2U40_02230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_02235	COG2222	sugar isomerase
C2U40_02245	COG1349	DNA-binding transcription factor activity
C2U40_02250	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U40_02255	COG4807	Protein conserved in bacteria
C2U40_02265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_02270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U40_02275	COG3956	TIGRFAM MazG family protein
C2U40_02280	COG0504	CTP synthase activity
C2U40_02285	COG0148	phosphopyruvate hydratase activity
C2U40_02290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U40_02295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U40_02305	COG0585	pseudouridine synthase activity
C2U40_02310	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U40_02315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U40_02320	COG1238	metal cluster binding
C2U40_02325	COG1388	LysM domain
C2U40_02325	COG4942	peptidase
C2U40_02335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U40_02340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U40_02345	COG1610	YqeY-like protein
C2U40_02350	COG0358	DNA primase activity
C2U40_02355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U40_02385	COG0151	Belongs to the GarS family
C2U40_02390	COG0138	bifunctional purine biosynthesis protein purh
C2U40_02400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2U40_02405	COG3036	rescue of stalled ribosome
C2U40_02410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U40_02415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U40_02425	COG0673	inositol 2-dehydrogenase activity
C2U40_02440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_02460	COG0477	Major facilitator Superfamily
C2U40_02475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U40_02480	COG1027	Aspartate ammonia-lyase
C2U40_02485	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U40_02490	COG0534	Mate efflux family protein
C2U40_02495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U40_02500	COG0459	protein refolding
C2U40_02510	COG3300	MHYT domain
C2U40_02510	COG5001	Diguanylate cyclase
C2U40_02520	COG0564	pseudouridine synthase activity
C2U40_02525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U40_02550	COG1280	lysine exporter protein (LysE YggA)
C2U40_02590	COG3311	Transcriptional regulator
C2U40_02630	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U40_02640	COG5377	YqaJ viral recombinase family
C2U40_02690	COG2003	Belongs to the UPF0758 family
C2U40_02740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_02745	COG0732	type I restriction modification DNA specificity domain
C2U40_02765	COG1484	DNA-dependent DNA replication
C2U40_02770	COG4584	PFAM Integrase catalytic
C2U40_02795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_02800	COG4584	PFAM Integrase catalytic
C2U40_02805	COG1484	DNA-dependent DNA replication
C2U40_02840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U40_02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_02885	COG0745	RESPONSE REGULATOR receiver
C2U40_02890	COG3104	oligopeptide transport
C2U40_02895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U40_02900	COG1555	photosystem II stabilization
C2U40_02910	COG2350	Protein conserved in bacteria
C2U40_02915	COG2917	probably involved in intracellular septation
C2U40_02920	COG0076	glutamate decarboxylase activity
C2U40_02925	COG1272	protein, Hemolysin III
C2U40_02930	COG2985	domain, Protein
C2U40_02930	COG0569	domain protein
C2U40_02940	COG0784	Response regulator, receiver
C2U40_02940	COG0835	chemotaxis
C2U40_02945	COG2755	lipolytic protein G-D-S-L family
C2U40_02950	COG4181	ATPase activity
C2U40_02955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U40_02960	COG1090	epimerase
C2U40_02965	COG2200	EAL domain
C2U40_02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_02975	COG4935	Belongs to the peptidase S8 family
C2U40_02975	COG2234	aminopeptidase activity
C2U40_02980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U40_02985	COG3171	Protein conserved in bacteria
C2U40_02990	COG2066	Belongs to the glutaminase family
C2U40_02995	COG2897	thiosulfate sulfurtransferase activity
C2U40_03000	COG1404	Belongs to the peptidase S8 family
C2U40_03010	COG1132	(ABC) transporter
C2U40_03035	COG0582	viral genome integration into host DNA
C2U40_03055	COG4974	Belongs to the 'phage' integrase family
C2U40_03090	COG2203	Gaf domain
C2U40_03090	COG4251	negative regulation of phosphorylation
C2U40_03090	COG5001	Diguanylate cyclase
C2U40_03090	COG3706	GGDEF domain
C2U40_03095	COG3291	Pkd domain containing protein
C2U40_03095	COG4412	M6 family metalloprotease domain protein
C2U40_03105	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U40_03110	COG5001	Diguanylate cyclase
C2U40_03110	COG3300	MHYT domain
C2U40_03130	COG4628	conserved protein (DUF2132)
C2U40_03135	COG0688	phosphatidylethanolamine metabolic process
C2U40_03140	COG1162	GTPase activity
C2U40_03145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U40_03185	COG1278	Cold shock
C2U40_03195	COG0840	transmembrane signaling receptor activity
C2U40_03200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_03255	COG0848	biopolymer transport protein
C2U40_03260	COG0811	peptide transport
C2U40_03265	COG0811	peptide transport
C2U40_03280	COG4174	ABC transporter (Permease)
C2U40_03285	COG4239	(ABC) transporter, permease
C2U40_03295	COG0444	Belongs to the ABC transporter superfamily
C2U40_03300	COG4608	Belongs to the ABC transporter superfamily
C2U40_03310	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U40_03320	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U40_03340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U40_03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_03370	COG2313	pseudouridylate synthase activity
C2U40_03375	COG3338	carbonate dehydratase activity
C2U40_03380	COG1858	cytochrome C peroxidase
C2U40_03415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_03420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_03445	COG2986	histidine ammonia-lyase
C2U40_03470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_03480	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_03485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_03495	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U40_03505	COG2966	Psort location CytoplasmicMembrane, score
C2U40_03510	COG3610	response to peptide
C2U40_03520	COG4175	Glycine betaine
C2U40_03525	COG4176	ABC-type proline glycine betaine transport system permease component
C2U40_03530	COG2113	Glycine betaine
C2U40_03535	COG0175	sulfate reduction
C2U40_03540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U40_03545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U40_03550	COG0384	phenazine biosynthesis protein PhzF
C2U40_03555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U40_03570	COG0786	glutamate:sodium symporter activity
C2U40_03575	COG0252	asparaginase activity
C2U40_03580	COG3139	Protein of unknown function (DUF1315)
C2U40_03600	COG0616	signal peptide processing
C2U40_03605	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_03605	COG1902	pentaerythritol trinitrate reductase activity
C2U40_03610	COG0778	Nitroreductase
C2U40_03625	COG2264	protein methyltransferase activity
C2U40_03635	COG0604	alcohol dehydrogenase
C2U40_03640	COG0583	DNA-binding transcription factor activity
C2U40_03645	COG1263	PTS System
C2U40_03645	COG2190	(PTS) system
C2U40_03645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_03650	COG4145	pantothenate transmembrane transporter activity
C2U40_03660	COG0439	Biotin carboxylase
C2U40_03665	COG0511	ligase activity, forming carbon-carbon bonds
C2U40_03670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U40_03675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U40_03685	COG5001	Diguanylate cyclase
C2U40_03685	COG3300	MHYT domain
C2U40_03705	COG3381	protein complex oligomerization
C2U40_03715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U40_03730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U40_03735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U40_03735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U40_03755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U40_03760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_03765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U40_03770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U40_03795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U40_03800	COG0142	geranyltranstransferase activity
C2U40_03805	COG1722	exodeoxyribonuclease VII activity
C2U40_03810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_03815	COG1360	Flagellar Motor Protein
C2U40_03820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U40_03830	COG1534	Rna-binding protein
C2U40_03835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U40_03840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U40_03845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U40_03850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U40_03855	COG0149	triose-phosphate isomerase activity
C2U40_03860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U40_03875	COG0779	Required for maturation of 30S ribosomal subunits
C2U40_03880	COG0195	Participates in both transcription termination and antitermination
C2U40_03885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U40_03890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U40_03895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U40_03900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U40_03905	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U40_03910	COG3385	transposase activity
C2U40_03915	COG2211	Major facilitator Superfamily
C2U40_03925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U40_03935	COG0114	fumarate hydratase activity
C2U40_03945	COG1966	Carbon starvation protein
C2U40_03950	COG3279	Response regulator of the LytR AlgR family
C2U40_03955	COG3275	phosphorelay sensor kinase activity
C2U40_04020	COG0312	modulator of DNA gyrase
C2U40_04025	COG0312	modulator of DNA gyrase
C2U40_04030	COG0716	FMN binding
C2U40_04035	COG4974	Belongs to the 'phage' integrase family
C2U40_04040	COG1970	mechanosensitive ion channel activity
C2U40_04045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_04055	COG0789	Transcriptional regulator
C2U40_04070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_04075	COG3545	Serine hydrolase
C2U40_04085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U40_04095	COG0321	lipoyl(octanoyl) transferase activity
C2U40_04100	COG2921	Belongs to the UPF0250 family
C2U40_04105	COG1686	Belongs to the peptidase S11 family
C2U40_04110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U40_04115	COG2951	lytic endotransglycosylase activity
C2U40_04120	COG0772	Belongs to the SEDS family
C2U40_04125	COG0768	penicillin binding
C2U40_04130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U40_04135	COG0799	negative regulation of ribosome biogenesis
C2U40_04140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U40_04160	COG0495	leucyl-tRNA aminoacylation
C2U40_04165	COG2888	peptidyl-tyrosine sulfation
C2U40_04170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U40_04175	COG4535	Mg2 and Co2 transporter CorC
C2U40_04180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U40_04185	COG1702	phosphate starvation-inducible protein PhoH
C2U40_04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U40_04195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_04200	COG1335	isochorismatase
C2U40_04210	COG3706	GGDEF domain
C2U40_04225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_04235	COG3706	GGDEF domain
C2U40_04245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U40_04255	COG3647	Membrane
C2U40_04260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U40_04275	COG0516	GMP reductase activity
C2U40_04295	COG0642	Histidine kinase
C2U40_04300	COG0745	RESPONSE REGULATOR receiver
C2U40_04330	COG4106	trans-aconitate 2-methyltransferase activity
C2U40_04335	COG3214	Protein conserved in bacteria
C2U40_04360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U40_04365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U40_04370	COG1053	succinate dehydrogenase
C2U40_04380	COG0584	glycerophosphoryl diester phosphodiesterase
C2U40_04385	COG3264	Mechanosensitive ion channel
C2U40_04385	COG1511	domain protein
C2U40_04395	COG0739	heme binding
C2U40_04410	COG0583	DNA-binding transcription factor activity
C2U40_04430	COG0583	DNA-binding transcription factor activity
C2U40_04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U40_04465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U40_04470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U40_04480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U40_04495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U40_04505	COG0180	Tryptophanyl-tRNA synthetase
C2U40_04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U40_04530	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_04540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_04550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U40_04550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_04550	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U40_04550	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U40_04560	COG0366	Alpha amylase catalytic
C2U40_04580	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U40_04590	COG0490	domain, Protein
C2U40_04590	COG0471	metal ion transport
C2U40_04675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U40_04750	COG0582	viral genome integration into host DNA
C2U40_04755	COG0012	GTP binding
C2U40_04760	COG0193	aminoacyl-tRNA hydrolase activity
C2U40_04765	COG0737	Belongs to the 5'-nucleotidase family
C2U40_04770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U40_04780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U40_04785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U40_04790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U40_04795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U40_04800	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U40_04810	COG2912	Transglutaminase-like superfamily
C2U40_04815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U40_04820	COG1301	dicarboxylic acid transport
C2U40_04830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U40_04845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U40_04850	COG1115	amino acid carrier protein
C2U40_04865	COG0714	Associated with various cellular activities
C2U40_04875	COG3104	oligopeptide transport
C2U40_04880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U40_04885	COG1678	Uncharacterized ACR, COG1678
C2U40_04895	COG0189	ligase activity
C2U40_04900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U40_04910	COG3091	SprT-like family
C2U40_04920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U40_04940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U40_04945	COG0739	heme binding
C2U40_04950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U40_04955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2U40_04955	COG3408	Glycogen debranching enzyme
C2U40_04965	COG1881	PFAM PEBP family protein
C2U40_04975	COG0583	DNA-binding transcription factor activity
C2U40_04985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U40_04995	COG0583	DNA-binding transcription factor activity
C2U40_05000	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_05005	COG0616	signal peptide processing
C2U40_05010	COG3724	N-succinylarginine dihydrolase activity
C2U40_05015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U40_05030	COG0840	transmembrane signaling receptor activity
C2U40_05040	COG2971	BadF BadG BcrA BcrD
C2U40_05050	COG4608	Belongs to the ABC transporter superfamily
C2U40_05055	COG0444	Belongs to the ABC transporter superfamily
C2U40_05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_05065	COG0601	transmembrane transport
C2U40_05070	COG4166	transmembrane transport
C2U40_05105	COG3220	belongs to the UPF0276 family
C2U40_05135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_05140	COG1289	transmembrane transporter activity
C2U40_05145	COG0303	'Molybdopterin
C2U40_05150	COG0746	molybdenum cofactor guanylyltransferase activity
C2U40_05160	COG4662	Binding-protein-dependent transport system inner membrane component
C2U40_05170	COG2204	response regulator
C2U40_05175	COG3852	Histidine kinase
C2U40_05180	COG1910	domain protein
C2U40_05185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U40_05200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_05230	COG3383	formate dehydrogenase (NAD+) activity
C2U40_05230	COG3383	formate dehydrogenase (NAD+) activity
C2U40_05235	COG0437	4 iron, 4 sulfur cluster binding
C2U40_05250	COG0281	malic enzyme
C2U40_05270	COG2706	6-phosphogluconolactonase activity
C2U40_05285	COG3264	Mechanosensitive ion channel
C2U40_05285	COG1196	nuclear chromosome segregation
C2U40_05290	COG0469	pyruvate kinase activity
C2U40_05305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U40_05305	COG4651	solute:proton antiporter activity
C2U40_05315	COG2974	May be involved in recombination
C2U40_05325	COG0420	3'-5' exonuclease activity
C2U40_05330	COG0419	ATPase involved in DNA repair
C2U40_05345	COG3038	cytochrome b561
C2U40_05355	COG3706	GGDEF domain
C2U40_05355	COG0745	RESPONSE REGULATOR receiver
C2U40_05360	COG2190	(PTS) system
C2U40_05370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_05375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U40_05380	COG0542	response to heat
C2U40_05395	COG1720	tRNA m6t6A37 methyltransferase activity
C2U40_05415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U40_05420	COG4988	ABC transporter
C2U40_05435	COG0745	RESPONSE REGULATOR receiver
C2U40_05445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U40_05460	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U40_05465	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U40_05480	COG0083	homoserine kinase activity
C2U40_05485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U40_05520	COG0813	purine-nucleoside phosphorylase activity
C2U40_05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_05535	COG2205	protein histidine kinase activity
C2U40_05540	COG3384	dioxygenase
C2U40_05550	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U40_05560	COG0531	amino acid
C2U40_05575	COG0531	amino acid
C2U40_05590	COG1917	Cupin 2, conserved barrel domain protein
C2U40_05590	COG1396	sequence-specific DNA binding
C2U40_05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_05615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_05625	COG2375	cellular response to nickel ion
C2U40_05630	COG1538	Outer membrane efflux protein
C2U40_05635	COG0577	efflux transmembrane transporter activity
C2U40_05635	COG1136	(ABC) transporter
C2U40_05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_05650	COG1227	inorganic diphosphatase activity
C2U40_05660	COG0497	DNA recombination
C2U40_05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U40_05670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U40_05675	COG0443	Heat shock 70 kDa protein
C2U40_05680	COG0484	heat shock protein binding
C2U40_05715	COG1285	pathogenesis
C2U40_05730	COG0640	Transcriptional regulator
C2U40_05740	COG2391	methyltransferase activity
C2U40_05760	COG0095	Lipoate-protein ligase
C2U40_05780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_05805	COG0708	Exodeoxyribonuclease III
C2U40_05820	COG2211	Major facilitator Superfamily
C2U40_05875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U40_05880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U40_05885	COG1845	cytochrome c oxidase, subunit III
C2U40_05890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U40_05895	COG0109	protoheme IX farnesyltransferase activity
C2U40_05900	COG2814	Major facilitator Superfamily
C2U40_05910	COG2198	Histidine kinase
C2U40_05910	COG0784	Response regulator, receiver
C2U40_05910	COG2205	protein histidine kinase activity
C2U40_05915	COG1879	ABC-type sugar transport system periplasmic component
C2U40_05925	COG0745	RESPONSE REGULATOR receiver
C2U40_05930	COG3005	denitrification pathway
C2U40_05940	COG3381	protein complex oligomerization
C2U40_05980	COG2003	Belongs to the UPF0758 family
C2U40_06020	COG0583	DNA-binding transcription factor activity
C2U40_06035	COG0549	Belongs to the carbamate kinase family
C2U40_06040	COG1304	FMN binding
C2U40_06045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U40_06050	COG1335	isochorismatase
C2U40_06065	COG3311	Transcriptional regulator
C2U40_06095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_06115	COG3550	peptidyl-serine autophosphorylation
C2U40_06120	COG1396	sequence-specific DNA binding
C2U40_06125	COG1988	membrane-bound metal-dependent
C2U40_06140	COG3039	Transposase
C2U40_06150	COG0159	tryptophan synthase activity
C2U40_06155	COG0133	tryptophan synthase activity
C2U40_06160	COG0134	indole-3-glycerol-phosphate synthase activity
C2U40_06160	COG0135	phosphoribosylanthranilate isomerase activity
C2U40_06165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U40_06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U40_06170	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U40_06175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U40_06185	COG0009	L-threonylcarbamoyladenylate synthase
C2U40_06195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U40_06205	COG1946	Acyl-CoA thioesterase
C2U40_06220	COG1309	transcriptional regulator
C2U40_06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_06230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_06235	COG1538	Outer membrane efflux protein
C2U40_06245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2U40_06260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U40_06285	COG0367	asparagine synthase
C2U40_06295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U40_06315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U40_06330	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U40_06345	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2U40_06355	COG3132	Protein of unknown function, DUF480
C2U40_06395	COG1278	Cold shock
C2U40_06420	COG4166	transmembrane transport
C2U40_06425	COG0697	spore germination
C2U40_06430	COG1349	DNA-binding transcription factor activity
C2U40_06440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_06445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U40_06460	COG1187	pseudouridine synthase activity
C2U40_06475	COG0622	Phosphoesterase
C2U40_06490	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U40_06495	COG0784	Response regulator, receiver
C2U40_06495	COG0835	chemotaxis
C2U40_06500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U40_06505	COG1815	bacterial-type flagellum-dependent cell motility
C2U40_06510	COG1558	bacterial-type flagellum-dependent cell motility
C2U40_06520	COG1749	Flagellar hook protein flgE
C2U40_06525	COG4787	bacterial-type flagellum-dependent cell motility
C2U40_06530	COG4786	Flagellar basal body rod
C2U40_06535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U40_06540	COG1706	bacterial-type flagellum-dependent cell motility
C2U40_06550	COG1256	bacterial-type flagellum assembly
C2U40_06560	COG2239	Acts as a magnesium transporter
C2U40_06565	COG0784	Response regulator, receiver
C2U40_06565	COG3437	response regulator, receiver
C2U40_06570	COG1960	acyl-CoA dehydrogenase activity
C2U40_06575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U40_06580	COG0121	glutamine amidotransferase
C2U40_06600	COG0784	Response regulator, receiver
C2U40_06600	COG2205	protein histidine kinase activity
C2U40_06610	COG2197	response regulator
C2U40_06615	COG3850	Histidine kinase
C2U40_06620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U40_06625	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_06625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_06635	COG0243	molybdopterin cofactor binding
C2U40_06640	COG0437	4 iron, 4 sulfur cluster binding
C2U40_06645	COG0348	domain, Protein
C2U40_06655	COG3005	denitrification pathway
C2U40_06660	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U40_06665	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U40_06670	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U40_06675	COG0314	molybdopterin synthase activity
C2U40_06690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U40_06695	COG2267	carboxylic ester hydrolase activity
C2U40_06720	COG0433	COG0433 Predicted ATPase
C2U40_06750	COG1132	(ABC) transporter
C2U40_06755	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U40_06760	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U40_06765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U40_06770	COG2197	response regulator
C2U40_06775	COG0322	excinuclease ABC activity
C2U40_06835	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U40_06840	COG0437	4 iron, 4 sulfur cluster binding
C2U40_06845	COG3301	Polysulphide reductase, NrfD
C2U40_06850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_06860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U40_06890	COG2199	diguanylate cyclase activity
C2U40_06890	COG2203	Gaf domain
C2U40_06920	COG2119	membrane
C2U40_06925	COG0023	Translation Initiation Factor
C2U40_06950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U40_06965	COG2205	protein histidine kinase activity
C2U40_06965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_06975	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U40_06985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_06990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U40_06995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U40_07000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U40_07005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U40_07015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U40_07020	COG0505	Belongs to the CarA family
C2U40_07025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U40_07030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U40_07060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_07065	COG0513	Belongs to the DEAD box helicase family
C2U40_07075	COG4104	PAAR repeat-containing protein
C2U40_07090	COG0789	Transcriptional regulator
C2U40_07105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_07110	COG0765	amino acid transport
C2U40_07120	COG0493	'glutamate synthase
C2U40_07125	COG0070	glutamate synthase
C2U40_07125	COG0069	glutamate synthase activity
C2U40_07125	COG0067	glutamate synthase
C2U40_07130	COG1242	4 iron, 4 sulfur cluster binding
C2U40_07200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U40_07205	COG0574	Belongs to the PEP-utilizing enzyme family
C2U40_07205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U40_07245	COG1464	Belongs to the NlpA lipoprotein family
C2U40_07250	COG0671	phosphoesterase, PA-phosphatase related
C2U40_07255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U40_07260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U40_07270	COG0101	tRNA pseudouridine synthase activity
C2U40_07275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U40_07280	COG0285	dihydrofolate synthase activity
C2U40_07285	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U40_07290	COG2920	part of a sulfur-relay system
C2U40_07295	COG1289	transmembrane transporter activity
C2U40_07300	COG0670	Belongs to the BI1 family
C2U40_07315	COG4792	protein secretion
C2U40_07320	COG4791	protein targeting
C2U40_07325	COG4794	Type iii secretion
C2U40_07330	COG4790	Type iii secretion
C2U40_07335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U40_07490	COG1317	bacterial-type flagellum organization
C2U40_07505	COG2194	sulfuric ester hydrolase activity
C2U40_07515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2U40_07515	COG0392	lysyltransferase activity
C2U40_07525	COG0840	transmembrane signaling receptor activity
C2U40_07530	COG5001	Diguanylate cyclase
C2U40_07535	COG0564	pseudouridine synthase activity
C2U40_07550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U40_07565	COG0625	glutathione transferase activity
C2U40_07570	COG0625	glutathione transferase activity
C2U40_07580	COG0367	asparagine synthase
C2U40_07590	COG4651	solute:proton antiporter activity
C2U40_07590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U40_07595	COG0647	UMP catabolic process
C2U40_07610	COG1902	pentaerythritol trinitrate reductase activity
C2U40_07615	COG1253	flavin adenine dinucleotide binding
C2U40_07625	COG0247	lactate metabolic process
C2U40_07625	COG0277	FAD linked oxidase domain protein
C2U40_07635	COG2050	protein possibly involved in aromatic compounds catabolism
C2U40_07645	COG2056	Na+-H+ antiporter family
C2U40_07650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U40_07665	COG0346	lactoylglutathione lyase activity
C2U40_07670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U40_07680	COG4659	FMN binding
C2U40_07685	COG4658	electron transport chain
C2U40_07695	COG2878	Part of a membrane complex involved in electron transport
C2U40_07700	COG4657	Part of a membrane complex involved in electron transport
C2U40_07705	COG0697	spore germination
C2U40_07725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U40_07730	COG1288	antiporter activity
C2U40_07735	COG0436	Aminotransferase
C2U40_07745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U40_07750	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U40_07755	COG1061	Type III restriction enzyme res subunit
C2U40_07760	COG1566	PFAM secretion protein HlyD family protein
C2U40_07770	COG1966	Carbon starvation protein
C2U40_07775	COG3279	Response regulator of the LytR AlgR family
C2U40_07780	COG3275	phosphorelay sensor kinase activity
C2U40_07785	COG2199	diguanylate cyclase activity
C2U40_07785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_07790	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_07790	COG1454	alcohol dehydrogenase
C2U40_07800	COG2095	MarC family integral membrane protein
C2U40_07810	COG0601	transmembrane transport
C2U40_07815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_07820	COG0444	Belongs to the ABC transporter superfamily
C2U40_07830	COG0861	Integral membrane protein TerC family
C2U40_07840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_07850	COG1301	dicarboxylic acid transport
C2U40_07865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U40_07880	COG0537	adenosine 5'-monophosphoramidase activity
C2U40_07915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_07920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_07930	COG2354	Protein conserved in bacteria
C2U40_07945	COG2233	PERMEase
C2U40_07955	COG1252	NADH dehydrogenase
C2U40_07975	COG0393	Putative heavy-metal-binding
C2U40_07985	COG4667	esterase of the alpha-beta hydrolase superfamily
C2U40_07990	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U40_07995	COG1368	sulfuric ester hydrolase activity
C2U40_08005	COG0527	aspartate kinase activity
C2U40_08010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U40_08010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U40_08015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_08040	COG0596	Alpha beta hydrolase
C2U40_08045	COG0346	lactoylglutathione lyase activity
C2U40_08055	COG0583	DNA-binding transcription factor activity
C2U40_08060	COG1620	l-lactate permease
C2U40_08070	COG1139	Iron-sulfur cluster binding protein
C2U40_08105	COG1136	(ABC) transporter
C2U40_08115	COG2814	Major facilitator Superfamily
C2U40_08135	COG0672	)-iron permease
C2U40_08165	COG0659	secondary active sulfate transmembrane transporter activity
C2U40_08190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_08195	COG0840	transmembrane signaling receptor activity
C2U40_08205	COG2201	protein-glutamate methylesterase activity
C2U40_08215	COG0835	chemotaxis
C2U40_08220	COG0840	transmembrane signaling receptor activity
C2U40_08225	COG2198	Histidine kinase
C2U40_08225	COG0643	Histidine kinase
C2U40_08235	COG0745	RESPONSE REGULATOR receiver
C2U40_08240	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2U40_08245	COG0437	4 iron, 4 sulfur cluster binding
C2U40_08250	COG5557	Pfam Polysulphide reductase, NrfD
C2U40_08255	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2U40_08260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U40_08265	COG1773	rubredoxin
C2U40_08280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_08285	COG0444	Belongs to the ABC transporter superfamily
C2U40_08290	COG1126	abc transporter atp-binding protein
C2U40_08295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2U40_08300	COG0375	protein maturation
C2U40_08305	COG0309	Hydrogenase expression formation protein (HypE)
C2U40_08315	COG0298	carbon dioxide binding
C2U40_08320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2U40_08330	COG1921	L-seryl-tRNASec selenium transferase activity
C2U40_08335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U40_08345	COG3260	NADH ubiquinone oxidoreductase 20
C2U40_08350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_08355	COG3261	NADH dehydrogenase
C2U40_08355	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2U40_08360	COG0650	Formate hydrogenlyase subunit 4
C2U40_08365	COG0651	ATP synthesis coupled electron transport
C2U40_08370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_08375	COG3158	transport of potassium into the cell
C2U40_08385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_08410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U40_08420	COG0326	Molecular chaperone. Has ATPase activity
C2U40_08430	COG0563	adenylate kinase activity
C2U40_08435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U40_08445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_08460	COG5001	Diguanylate cyclase
C2U40_08460	COG3300	MHYT domain
C2U40_08485	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U40_08490	COG3433	isochorismatase activity
C2U40_08490	COG1535	isochorismatase
C2U40_08495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U40_08500	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U40_08515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U40_08525	COG1120	ATPase activity
C2U40_08530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_08535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_08540	COG4771	TonB-dependent receptor
C2U40_08560	COG0598	Magnesium transport protein CorA
C2U40_08580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U40_08585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U40_08590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_08605	COG1570	exodeoxyribonuclease VII activity
C2U40_08610	COG0697	spore germination
C2U40_08630	COG3158	transport of potassium into the cell
C2U40_08635	COG0517	IMP dehydrogenase activity
C2U40_08635	COG0516	GMP reductase activity
C2U40_08640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U40_08640	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_08680	COG2062	phosphohistidine phosphatase, SixA
C2U40_08690	COG0697	spore germination
C2U40_08695	COG4166	transmembrane transport
C2U40_08700	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U40_08705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U40_08715	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U40_08720	COG1136	(ABC) transporter
C2U40_08725	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U40_08730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U40_08745	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U40_08750	COG0740	serine-type endopeptidase activity
C2U40_08755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U40_08760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U40_08765	COG0776	regulation of translation
C2U40_08770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U40_08775	COG0488	(ABC) transporter
C2U40_08780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U40_08785	COG3162	membrane
C2U40_08800	COG1024	Enoyl-CoA hydratase
C2U40_08805	COG1115	amino acid carrier protein
C2U40_08820	COG1584	GPR1 FUN34 yaaH family protein
C2U40_08855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U40_08860	COG1960	acyl-CoA dehydrogenase activity
C2U40_08870	COG1960	acyl-CoA dehydrogenase activity
C2U40_08875	COG1024	Enoyl-CoA hydratase
C2U40_08880	COG1024	Enoyl-CoA hydratase
C2U40_08890	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_08900	COG0730	response to heat
C2U40_08940	COG0583	DNA-binding transcription factor activity
C2U40_08945	COG2723	6-phospho-beta-galactosidase activity
C2U40_08950	COG3300	MHYT domain
C2U40_08950	COG5001	Diguanylate cyclase
C2U40_08960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_08970	COG0583	DNA-binding transcription factor activity
C2U40_08975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U40_08980	COG0673	inositol 2-dehydrogenase activity
C2U40_08985	COG0583	DNA-binding transcription factor activity
C2U40_08995	COG1560	Kdo2-lipid A biosynthetic process
C2U40_09000	COG1560	Kdo2-lipid A biosynthetic process
C2U40_09025	COG0417	DNA replication proofreading
C2U40_09055	COG0534	Mate efflux family protein
C2U40_09065	COG0307	riboflavin synthase, alpha
C2U40_09075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_09080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U40_09085	COG0697	spore germination
C2U40_09090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U40_09130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_09140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U40_09145	COG2894	cell division
C2U40_09150	COG0850	regulation of cytokinetic process
C2U40_09155	COG3100	YcgL domain-containing protein
C2U40_09160	COG2951	lytic endotransglycosylase activity
C2U40_09165	COG1760	l-serine dehydratase
C2U40_09175	COG1760	l-serine dehydratase
C2U40_09180	COG3123	guanosine phosphorylase activity
C2U40_09200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U40_09205	COG2067	long-chain fatty acid transport protein
C2U40_09210	COG2067	long-chain fatty acid transport protein
C2U40_09220	COG1595	DNA-templated transcription, initiation
C2U40_09250	COG0714	Associated with various cellular activities
C2U40_09255	COG0183	Belongs to the thiolase family
C2U40_09260	COG1024	Enoyl-CoA hydratase
C2U40_09260	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U40_09270	COG4681	YaeQ
C2U40_09305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U40_09310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U40_09315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U40_09325	COG0549	Belongs to the carbamate kinase family
C2U40_09330	COG0697	spore germination
C2U40_09335	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2U40_09335	COG3608	succinylglutamate desuccinylase aspartoacylase
C2U40_09340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U40_09345	COG2068	MobA-Related Protein
C2U40_09360	COG4644	lycopene metabolic process
C2U40_09410	COG1309	transcriptional regulator
C2U40_09415	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_09430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_09435	COG0783	Belongs to the Dps family
C2U40_09455	COG0183	Belongs to the thiolase family
C2U40_09465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U40_09520	COG0625	glutathione transferase activity
C2U40_09525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_09535	COG0583	DNA-binding transcription factor activity
C2U40_09545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_09560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U40_09580	COG1846	Transcriptional regulator
C2U40_09585	COG0583	DNA-binding transcription factor activity
C2U40_09595	COG2948	multi-organism process
C2U40_09610	COG3846	protein secretion by the type IV secretion system
C2U40_09625	COG3451	type IV secretory pathway VirB4
C2U40_09640	COG4962	Type ii secretion system protein e
C2U40_09660	COG0741	lytic transglycosylase activity
C2U40_09680	COG0840	transmembrane signaling receptor activity
C2U40_09695	COG4644	lycopene metabolic process
C2U40_09705	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_09710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2U40_09715	COG2080	2 iron, 2 sulfur cluster binding
C2U40_09715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U40_09720	COG2233	PERMEase
C2U40_09725	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_09730	COG2252	PERMEase
C2U40_09735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U40_09740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2U40_09745	COG2080	2 iron, 2 sulfur cluster binding
C2U40_09755	COG3134	Outer membrane lipoprotein
C2U40_09765	COG1288	antiporter activity
C2U40_09770	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_09775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U40_09775	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U40_09780	COG0107	imidazoleglycerol-phosphate synthase activity
C2U40_09785	COG2205	protein histidine kinase activity
C2U40_09785	COG2198	Histidine kinase
C2U40_09785	COG0784	Response regulator, receiver
C2U40_09795	COG3437	response regulator, receiver
C2U40_09800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U40_09805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U40_09810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U40_09810	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U40_09815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U40_09820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U40_09825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U40_09835	COG1199	ATP-dependent helicase activity
C2U40_09845	COG1214	PFAM Peptidase M22, glycoprotease
C2U40_09855	COG2226	methyltransferase
C2U40_09855	COG0596	Alpha beta hydrolase
C2U40_09855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U40_09860	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_09865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2U40_09880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U40_09885	COG2832	Protein of unknown function (DUF454)
C2U40_09890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U40_09895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U40_09900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U40_09920	COG1643	Atp-dependent helicase
C2U40_09930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U40_09940	COG3437	response regulator, receiver
C2U40_09945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U40_09950	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U40_09955	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U40_09970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U40_09980	COG0840	transmembrane signaling receptor activity
C2U40_09985	COG1254	Belongs to the acylphosphatase family
C2U40_09990	COG0625	glutathione transferase activity
C2U40_09995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_10000	COG0489	protein tyrosine kinase activity
C2U40_10005	COG0572	uridine kinase
C2U40_10010	COG0717	Belongs to the dCTP deaminase family
C2U40_10015	COG0306	phosphate transporter
C2U40_10025	COG1530	ribonuclease E activity
C2U40_10030	COG0564	pseudouridine synthase activity
C2U40_10035	COG0546	phosphoglycolate phosphatase activity
C2U40_10040	COG0424	maF-like protein
C2U40_10045	COG2814	Major facilitator Superfamily
C2U40_10060	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U40_10065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U40_10070	COG0416	fatty acid biosynthetic process
C2U40_10075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U40_10085	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_10090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_10100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U40_10105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U40_10110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U40_10115	COG0470	DNA polymerase III
C2U40_10120	COG0084	hydrolase, TatD family'
C2U40_10140	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U40_10140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_10145	COG3008	intermembrane lipid transfer
C2U40_10150	COG2995	paraquat-inducible protein a
C2U40_10160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U40_10165	COG0372	Belongs to the citrate synthase family
C2U40_10210	COG4221	oxidoreductase activity
C2U40_10220	COG3141	response to X-ray
C2U40_10230	COG1067	ATP-dependent peptidase activity
C2U40_10235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U40_10250	COG0488	(ABC) transporter
C2U40_10260	COG0116	Belongs to the methyltransferase superfamily
C2U40_10260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U40_10270	COG0167	dihydroorotate dehydrogenase activity
C2U40_10275	COG2902	Dehydrogenase
C2U40_10285	COG0308	aminopeptidase N
C2U40_10295	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U40_10300	COG1956	GAF domain-containing protein
C2U40_10310	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U40_10325	COG2010	Cytochrome c
C2U40_10350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U40_10355	COG0589	response to stress
C2U40_10360	COG0037	tRNA processing
C2U40_10375	COG0625	glutathione transferase activity
C2U40_10380	COG1869	D-ribose catabolic process
C2U40_10385	COG1129	ABC transporter
C2U40_10390	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U40_10395	COG1879	ABC-type sugar transport system periplasmic component
C2U40_10400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_10405	COG1609	Transcriptional regulator
C2U40_10410	COG5001	Diguanylate cyclase
C2U40_10410	COG3300	MHYT domain
C2U40_10420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U40_10440	COG0776	regulation of translation
C2U40_10445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_10445	COG0072	phenylalanine-tRNA ligase activity
C2U40_10450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U40_10455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U40_10460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U40_10465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U40_10470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U40_10490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U40_10500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_10505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_10510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_10515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U40_10520	COG3313	Fe-S protein
C2U40_10525	COG2942	2-epimerase
C2U40_10530	COG3716	PTS system mannose fructose sorbose family IID component
C2U40_10535	COG3715	PTS system
C2U40_10540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_10540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_10555	COG1609	Transcriptional regulator
C2U40_10560	COG2140	Oxalate decarboxylase
C2U40_10565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_10565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_10565	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U40_10570	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U40_10575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_10575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_10580	COG1609	Transcriptional regulator
C2U40_10585	COG0814	amino acid
C2U40_10595	COG5654	RES domain protein
C2U40_10600	COG0513	Belongs to the DEAD box helicase family
C2U40_10610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U40_10615	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U40_10620	COG2840	Smr protein MutS2
C2U40_10630	COG3706	GGDEF domain
C2U40_10635	COG0588	phosphoglycerate mutase activity
C2U40_10660	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U40_10730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U40_10735	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U40_10745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U40_10750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U40_10760	COG0205	6-phosphofructokinase activity
C2U40_10765	COG1473	amidohydrolase
C2U40_10770	COG1011	Hydrolase
C2U40_10775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U40_10830	COG3593	DNA synthesis involved in DNA repair
C2U40_10845	COG0583	DNA-binding transcription factor activity
C2U40_10850	COG0730	response to heat
C2U40_10865	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U40_10880	COG0386	Belongs to the glutathione peroxidase family
C2U40_10885	COG0513	Belongs to the DEAD box helicase family
C2U40_10890	COG0456	acetyltransferase
C2U40_10900	COG1742	UPF0060 membrane protein
C2U40_10930	COG2329	Antibiotic biosynthesis monooxygenase
C2U40_10935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U40_10960	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U40_10970	COG2501	S4 domain
C2U40_10980	COG1132	(ABC) transporter
C2U40_10990	COG1132	(ABC) transporter
C2U40_11000	COG3118	belongs to the thioredoxin family
C2U40_11005	COG0471	metal ion transport
C2U40_11010	COG0058	SHG alpha-glucan phosphorylase activity
C2U40_11045	COG0814	amino acid
C2U40_11050	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U40_11055	COG0514	ATP-dependent DNA helicase (RecQ)
C2U40_11060	COG2766	serine protein kinase
C2U40_11070	COG2719	SpoVR family
C2U40_11075	COG2186	Transcriptional regulator
C2U40_11080	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_11085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U40_11090	COG0586	Pfam SNARE associated Golgi protein
C2U40_11100	COG0556	nucleotide-excision repair
C2U40_11115	COG0569	domain protein
C2U40_11115	COG2985	domain, Protein
C2U40_11120	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U40_11140	COG4565	transcriptional regulatory protein
C2U40_11145	COG3290	protein histidine kinase activity
C2U40_11150	COG1846	Transcriptional regulator
C2U40_11150	COG1940	carbohydrate kinase activity
C2U40_11155	COG0840	transmembrane signaling receptor activity
C2U40_11160	COG3012	SEC-C Motif Domain Protein
C2U40_11165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U40_11170	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U40_11175	COG0247	lactate metabolic process
C2U40_11185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U40_11190	COG0437	4 iron, 4 sulfur cluster binding
C2U40_11195	COG3301	Polysulphide reductase, NrfD
C2U40_11200	COG1138	Cytochrome C-type biogenesis protein
C2U40_11210	COG3088	subunit of a heme lyase
C2U40_11210	COG4235	cytochrome complex assembly
C2U40_11225	COG3033	Beta-eliminating lyase
C2U40_11235	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U40_11240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_11265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U40_11270	COG0583	DNA-binding transcription factor activity
C2U40_11280	COG4774	siderophore transport
C2U40_11285	COG4977	sequence-specific DNA binding
C2U40_11295	COG0583	DNA-binding transcription factor activity
C2U40_11300	COG2910	NAD(P)H-binding
C2U40_11315	COG0612	Peptidase, M16
C2U40_11320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U40_11325	COG2076	Multidrug Resistance protein
C2U40_11330	COG1944	ATP diphosphatase activity
C2U40_11335	COG2116	formate transmembrane transporter activity
C2U40_11340	COG1882	Formate acetyltransferase
C2U40_11345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_11355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U40_11365	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U40_11370	COG3842	ATPase activity
C2U40_11380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_11390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U40_11395	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U40_11400	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U40_11405	COG0567	Dehydrogenase, E1 component
C2U40_11415	COG1053	succinate dehydrogenase
C2U40_11420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U40_11425	COG2009	succinate dehydrogenase
C2U40_11445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_11450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_11450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U40_11460	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U40_11475	COG1451	nucleotide metabolic process
C2U40_11490	COG0254	rRNA binding
C2U40_11495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U40_11505	COG0583	DNA-binding transcription factor activity
C2U40_11515	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U40_11525	COG1879	ABC-type sugar transport system periplasmic component
C2U40_11530	COG1069	ribulokinase activity
C2U40_11540	COG2160	L-arabinose isomerase activity
C2U40_11545	COG2925	Exonuclease
C2U40_11555	COG3345	alpha-galactosidase
C2U40_11560	COG1380	Effector of murein hydrolase LrgA
C2U40_11565	COG1346	cytolysis
C2U40_11570	COG0295	cytidine deaminase activity
C2U40_11575	COG1022	Amp-dependent synthetase and ligase
C2U40_11590	COG0861	Integral membrane protein TerC family
C2U40_11595	COG2885	chlorophyll binding
C2U40_11600	COG2199	diguanylate cyclase activity
C2U40_11620	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U40_11630	COG3768	UPF0283 membrane protein
C2U40_11635	COG3106	COG3106 Predicted ATPase
C2U40_11650	COG1842	Phage shock protein A
C2U40_11655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U40_11665	COG4168	peptide transport system, permease
C2U40_11670	COG4171	peptide transport system, permease
C2U40_11680	COG4172	Belongs to the ABC transporter superfamily
C2U40_11690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U40_11695	COG1286	toxin biosynthetic process
C2U40_11700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U40_11710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U40_11715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U40_11720	COG1674	ftsk spoiiie
C2U40_11720	COG0531	amino acid
C2U40_11730	COG0686	Belongs to the AlaDH PNT family
C2U40_11735	COG0492	ferredoxin-NADP+ reductase activity
C2U40_11745	COG3706	GGDEF domain
C2U40_11750	COG3134	Outer membrane lipoprotein
C2U40_11755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U40_11760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U40_11765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U40_11770	COG0542	response to heat
C2U40_11775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U40_11780	COG1278	Cold shock
C2U40_11785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U40_11815	COG3501	Rhs element vgr protein
C2U40_11910	COG3209	COG3209 Rhs family protein
C2U40_11920	COG3501	Rhs element vgr protein
C2U40_11950	COG1435	thymidine kinase activity
C2U40_11955	COG1757	Na H antiporter
C2U40_11960	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U40_11965	COG2096	Adenosyltransferase
C2U40_11970	COG3530	Putative quorum-sensing-regulated virulence factor
C2U40_11975	COG0602	queuosine metabolic process
C2U40_11980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U40_12000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U40_12010	COG0776	regulation of translation
C2U40_12015	COG0539	negative regulation of cytoplasmic translation
C2U40_12020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U40_12025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U40_12035	COG0583	DNA-binding transcription factor activity
C2U40_12055	COG0778	Nitroreductase
C2U40_12060	COG5001	Diguanylate cyclase
C2U40_12060	COG3300	MHYT domain
C2U40_12070	COG0583	DNA-binding transcription factor activity
C2U40_12075	COG3437	response regulator, receiver
C2U40_12100	COG4989	oxidoreductase activity
C2U40_12105	COG0724	RNA recognition motif
C2U40_12125	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U40_12140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_12145	COG1360	Flagellar Motor Protein
C2U40_12150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_12155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_12160	COG0649	NAD binding
C2U40_12160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_12175	COG1034	ATP synthesis coupled electron transport
C2U40_12180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U40_12185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_12190	COG0839	Belongs to the complex I subunit 6 family
C2U40_12195	COG0713	ATP synthesis coupled electron transport
C2U40_12205	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_12210	COG1007	ATP synthesis coupled electron transport
C2U40_12225	COG2199	diguanylate cyclase activity
C2U40_12225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_12230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U40_12230	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U40_12235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U40_12245	COG1645	bacterial-type flagellum-dependent swarming motility
C2U40_12255	COG1160	GTP binding
C2U40_12260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_12265	COG2976	Protein conserved in bacteria
C2U40_12270	COG0124	histidyl-tRNA synthetase
C2U40_12275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2U40_12280	COG1426	Protein conserved in bacteria
C2U40_12290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U40_12295	COG0105	UTP biosynthetic process
C2U40_12310	COG0633	Ferredoxin
C2U40_12315	COG0443	Heat shock 70 kDa protein
C2U40_12320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U40_12330	COG0822	iron-sulfur transferase activity
C2U40_12335	COG1104	cysteine desulfurase activity
C2U40_12380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_12385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_12390	COG1862	Preprotein translocase
C2U40_12395	COG0343	queuine tRNA-ribosyltransferase activity
C2U40_12400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U40_12405	COG0517	IMP dehydrogenase activity
C2U40_12410	COG0450	alkyl hydroperoxide reductase
C2U40_12415	COG3634	alkyl hydroperoxide reductase activity
C2U40_12435	COG1393	Belongs to the ArsC family
C2U40_12440	COG0798	PFAM Bile acid sodium symporter
C2U40_12455	COG0640	Transcriptional regulator
C2U40_12470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U40_12470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U40_12475	COG0509	glycine decarboxylation via glycine cleavage system
C2U40_12480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U40_12485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_12490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_12510	COG2814	Major facilitator Superfamily
C2U40_12515	COG0625	glutathione transferase activity
C2U40_12555	COG0483	inositol monophosphate 1-phosphatase activity
C2U40_12575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U40_12640	COG0301	tRNA thio-modification
C2U40_12640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_12675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_12730	COG4953	penicillin-binding protein 1C
C2U40_12735	COG2373	Large extracellular alpha-helical protein
C2U40_12740	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_12750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_12765	COG4215	(ABC) transporter
C2U40_12770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_12780	COG2431	L-lysine efflux transmembrane transporter activity
C2U40_12785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_12790	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C2U40_12805	COG1393	Belongs to the ArsC family
C2U40_12815	COG4783	chaperone-mediated protein folding
C2U40_12820	COG0425	Belongs to the sulfur carrier protein TusA family
C2U40_12845	COG3842	ATPase activity
C2U40_12855	COG1175	transmembrane transport
C2U40_12865	COG3081	Nucleoid-associated protein
C2U40_12870	COG3082	Protein of unknown function (DUF1414)
C2U40_12875	COG3083	sulfuric ester hydrolase activity
C2U40_12880	COG4771	TonB-dependent receptor
C2U40_12885	COG1770	oligopeptidase
C2U40_12905	COG4574	serine-type endopeptidase inhibitor activity
C2U40_12910	COG3085	chromosome segregation
C2U40_12915	COG0583	DNA-binding transcription factor activity
C2U40_12920	COG1605	Chorismate mutase
C2U40_12920	COG0287	Prephenate dehydrogenase
C2U40_12925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_12930	COG0584	glycerophosphoryl diester phosphodiesterase
C2U40_12945	COG1349	DNA-binding transcription factor activity
C2U40_12950	COG2271	Major facilitator Superfamily
C2U40_12955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U40_12960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U40_12965	COG0583	DNA-binding transcription factor activity
C2U40_12990	COG0656	L-ascorbic acid biosynthetic process
C2U40_12995	COG2814	Major facilitator Superfamily
C2U40_13005	COG1294	oxidase, subunit
C2U40_13010	COG1271	oxidase subunit
C2U40_13015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_13020	COG2979	Protein of unknown function (DUF533)
C2U40_13045	COG2271	Major facilitator Superfamily
C2U40_13050	COG0583	DNA-binding transcription factor activity
C2U40_13060	COG2807	transmembrane transport
C2U40_13065	COG1187	pseudouridine synthase activity
C2U40_13085	COG0346	lactoylglutathione lyase activity
C2U40_13095	COG1403	HNH endonuclease
C2U40_13110	COG3681	Belongs to the UPF0597 family
C2U40_13120	COG0814	amino acid
C2U40_13140	COG1166	arginine decarboxylase activity
C2U40_13160	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U40_13190	COG0583	DNA-binding transcription factor activity
C2U40_13200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U40_13205	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U40_13210	COG0840	transmembrane signaling receptor activity
C2U40_13215	COG0302	gtp cyclohydrolase
C2U40_13225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U40_13230	COG1448	Aminotransferase
C2U40_13255	COG1199	ATP-dependent helicase activity
C2U40_13265	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U40_13270	COG0477	Major facilitator Superfamily
C2U40_13275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U40_13300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U40_13315	COG2271	Major facilitator Superfamily
C2U40_13320	COG3706	GGDEF domain
C2U40_13325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_13330	COG0765	amino acid transport
C2U40_13335	COG1126	abc transporter atp-binding protein
C2U40_13350	COG0531	amino acid
C2U40_13365	COG1253	flavin adenine dinucleotide binding
C2U40_13370	COG0704	Plays a role in the regulation of phosphate uptake
C2U40_13380	COG0581	inorganic phosphate transmembrane transporter activity
C2U40_13385	COG0573	inorganic phosphate transmembrane transporter activity
C2U40_13390	COG0590	tRNA wobble adenosine to inosine editing
C2U40_13400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U40_13420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U40_13425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U40_13430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U40_13435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U40_13440	COG2204	response regulator
C2U40_13445	COG3852	Histidine kinase
C2U40_13450	COG2204	response regulator
C2U40_13460	COG2716	regulation of RNA biosynthetic process
C2U40_13465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U40_13470	COG0248	Ppx GppA phosphatase
C2U40_13480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U40_13485	COG0328	RNA-DNA hybrid ribonuclease activity
C2U40_13490	COG2226	methyltransferase
C2U40_13495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U40_13500	COG0741	lytic transglycosylase activity
C2U40_13500	COG1388	LysM domain
C2U40_13505	COG3385	transposase activity
C2U40_13510	COG3021	interspecies interaction between organisms
C2U40_13520	COG1607	acyl-coa hydrolase
C2U40_13535	COG0741	lytic transglycosylase activity
C2U40_13545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U40_13565	COG2911	Protein conserved in bacteria
C2U40_13570	COG0729	surface antigen
C2U40_13580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U40_13585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_13595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U40_13605	COG4134	Bacterial extracellular solute-binding protein
C2U40_13615	COG4136	ATPase activity
C2U40_13620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U40_13625	COG2951	lytic endotransglycosylase activity
C2U40_13640	COG1846	Transcriptional regulator
C2U40_13650	COG0033	Phosphoglucomutase
C2U40_13655	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U40_13660	COG0596	Alpha beta hydrolase
C2U40_13675	COG0716	FMN binding
C2U40_13685	COG0735	belongs to the Fur family
C2U40_13690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_13700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_13700	COG2190	(PTS) system
C2U40_13700	COG1263	PTS System
C2U40_13705	COG0363	glucosamine-6-phosphate deaminase activity
C2U40_13710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_13715	COG1940	carbohydrate kinase activity
C2U40_13715	COG1846	Transcriptional regulator
C2U40_13720	COG2194	sulfuric ester hydrolase activity
C2U40_13725	COG0217	transcriptional regulatory protein
C2U40_13730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U40_13735	COG1801	Protein of unknown function DUF72
C2U40_13740	COG4106	trans-aconitate 2-methyltransferase activity
C2U40_13745	COG0500	methyltransferase
C2U40_13765	COG0450	alkyl hydroperoxide reductase
C2U40_13770	COG0583	DNA-binding transcription factor activity
C2U40_13780	COG0791	NLP P60 protein
C2U40_13795	COG1309	transcriptional regulator
C2U40_13835	COG0534	Mate efflux family protein
C2U40_13850	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U40_13850	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U40_13850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U40_13850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U40_13860	COG0633	Ferredoxin
C2U40_13860	COG3217	Mosc domain protein beta barrel domain protein
C2U40_13860	COG3217	Mosc domain protein beta barrel domain protein
C2U40_13860	COG0633	Ferredoxin
C2U40_13875	COG0501	Belongs to the peptidase M48B family
C2U40_13880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U40_13885	COG1073	alpha beta
C2U40_13885	COG2226	methyltransferase
C2U40_13890	COG0156	8-amino-7-oxononanoate synthase activity
C2U40_13895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U40_13915	COG0017	Asparaginyl-tRNA synthetase
C2U40_13920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U40_13935	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U40_13945	COG0583	DNA-binding transcription factor activity
C2U40_13955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_13965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_13970	COG1393	Belongs to the ArsC family
C2U40_13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U40_13980	COG1876	peptidase activity
C2U40_13990	COG3263	regulation of cellular component size
C2U40_14010	COG1280	lysine exporter protein (LysE YggA)
C2U40_14035	COG1957	nucleoside hydrolase
C2U40_14040	COG0564	pseudouridine synthase activity
C2U40_14050	COG1454	alcohol dehydrogenase
C2U40_14055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_14060	COG0702	epimerase
C2U40_14070	COG2867	negative regulation of translational initiation
C2U40_14075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U40_14085	COG0582	viral genome integration into host DNA
C2U40_14095	COG4983	Phage plasmid primase, P4 family domain protein
C2U40_14110	COG5377	YqaJ viral recombinase family
C2U40_14155	COG2003	Belongs to the UPF0758 family
C2U40_14210	COG3039	Transposase
C2U40_14225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U40_14250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_14290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_14300	COG2814	Major facilitator Superfamily
C2U40_14300	COG0477	Major facilitator Superfamily
C2U40_14305	COG0457	Tetratricopeptide repeat
C2U40_14310	COG1940	carbohydrate kinase activity
C2U40_14315	COG0583	DNA-binding transcription factor activity
C2U40_14320	COG3048	D-serine ammonia-lyase activity
C2U40_14335	COG0538	isocitrate dehydrogenase activity
C2U40_14340	COG2207	Transcriptional regulator
C2U40_14360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_14375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U40_14380	COG1263	PTS System
C2U40_14380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_14385	COG1609	Transcriptional regulator
C2U40_14420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_14420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_14420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_14440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_14450	COG1187	pseudouridine synthase activity
C2U40_14460	COG0482	sulfurtransferase activity
C2U40_14465	COG2915	High frequency lysogenization protein hflD homolog
C2U40_14470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U40_14475	COG2850	peptidyl-arginine hydroxylation
C2U40_14485	COG3153	acetyltransferase
C2U40_14495	COG0625	glutathione transferase activity
C2U40_14500	COG0259	pyridoxamine-phosphate oxidase activity
C2U40_14515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_14515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_14520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U40_14535	COG3088	subunit of a heme lyase
C2U40_14535	COG4235	cytochrome complex assembly
C2U40_14540	COG4235	cytochrome complex assembly
C2U40_14540	COG3088	subunit of a heme lyase
C2U40_14545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U40_14550	COG1138	Cytochrome C-type biogenesis protein
C2U40_14555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U40_14560	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_14565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_14570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_14585	COG0835	chemotaxis
C2U40_14595	COG1192	Involved in chromosome partitioning
C2U40_14600	COG1360	Flagellar Motor Protein
C2U40_14605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_14610	COG2201	protein-glutamate methylesterase activity
C2U40_14615	COG0643	Histidine kinase
C2U40_14615	COG2198	Histidine kinase
C2U40_14620	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U40_14635	COG0455	bacterial-type flagellum organization
C2U40_14645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U40_14655	COG1684	flagellar biosynthetic protein fliR
C2U40_14660	COG1987	bacterial-type flagellum assembly
C2U40_14710	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U40_14720	COG1677	Flagellar hook-basal body complex protein FliE
C2U40_14735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U40_14740	COG0745	RESPONSE REGULATOR receiver
C2U40_14755	COG1737	Transcriptional regulator
C2U40_14760	COG0469	pyruvate kinase activity
C2U40_14775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_14780	COG1960	acyl-CoA dehydrogenase activity
C2U40_14790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U40_14810	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_14825	COG1342	Belongs to the UPF0251 family
C2U40_14830	COG0602	queuosine metabolic process
C2U40_14835	COG0242	peptide deformylase activity
C2U40_14840	COG1484	DNA-dependent DNA replication
C2U40_14845	COG4584	PFAM Integrase catalytic
C2U40_14850	COG0242	peptide deformylase activity
C2U40_14910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U40_14920	COG1136	(ABC) transporter
C2U40_14975	COG0243	molybdopterin cofactor binding
C2U40_14980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U40_14985	COG0583	DNA-binding transcription factor activity
C2U40_14995	COG1376	ErfK ybiS ycfS ynhG family protein
C2U40_14995	COG1388	LysM domain
C2U40_15010	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U40_15015	COG0791	NLP P60 protein
C2U40_15020	COG2091	lysine biosynthetic process via aminoadipic acid
C2U40_15025	COG3118	belongs to the thioredoxin family
C2U40_15035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U40_15040	COG0788	formyltetrahydrofolate deformylase activity
C2U40_15050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_15070	COG0366	Alpha amylase catalytic
C2U40_15075	COG1196	nuclear chromosome segregation
C2U40_15075	COG0739	heme binding
C2U40_15075	COG0741	lytic transglycosylase activity
C2U40_15080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U40_15085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U40_15095	COG0673	inositol 2-dehydrogenase activity
C2U40_15125	COG1032	radical SAM domain protein
C2U40_15135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_15140	COG1566	PFAM secretion protein HlyD family protein
C2U40_15145	COG2203	Gaf domain
C2U40_15145	COG2199	diguanylate cyclase activity
C2U40_15150	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U40_15155	COG0733	neurotransmitter:sodium symporter activity
C2U40_15190	COG0281	malic enzyme
C2U40_15200	COG0534	Mate efflux family protein
C2U40_15210	COG3706	GGDEF domain
C2U40_15210	COG0745	RESPONSE REGULATOR receiver
C2U40_15215	COG2233	PERMEase
C2U40_15220	COG0095	Lipoate-protein ligase
C2U40_15225	COG1115	amino acid carrier protein
C2U40_15230	COG0019	diaminopimelate decarboxylase activity
C2U40_15240	COG0678	peroxiredoxin activity
C2U40_15250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U40_15270	COG1131	(ABC) transporter
C2U40_15280	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U40_15290	COG3142	Participates in the control of copper homeostasis
C2U40_15305	COG4783	chaperone-mediated protein folding
C2U40_15315	COG5002	protein histidine kinase activity
C2U40_15320	COG0745	RESPONSE REGULATOR receiver
C2U40_15325	COG0346	lactoylglutathione lyase activity
C2U40_15330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U40_15335	COG1960	acyl-CoA dehydrogenase activity
C2U40_15340	COG3284	Transcriptional regulator
C2U40_15345	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_15355	COG0697	spore germination
C2U40_15365	COG4565	transcriptional regulatory protein
C2U40_15370	COG3290	protein histidine kinase activity
C2U40_15375	COG0281	malic enzyme
C2U40_15390	COG1846	Transcriptional regulator
C2U40_15395	COG1566	PFAM secretion protein HlyD family protein
C2U40_15425	COG0602	queuosine metabolic process
C2U40_15430	COG1328	CTP reductase activity
C2U40_15440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U40_15445	COG3115	cell septum assembly
C2U40_15450	COG1196	nuclear chromosome segregation
C2U40_15460	COG2860	membrane
C2U40_15470	COG3108	Peptidase M15
C2U40_15475	COG2989	Protein conserved in bacteria
C2U40_15490	COG0463	Glycosyl transferase, family 2
C2U40_15510	COG0366	Alpha amylase catalytic
C2U40_15545	COG3706	GGDEF domain
C2U40_15555	COG3590	peptidase
C2U40_15565	COG0488	(ABC) transporter
C2U40_15575	COG0531	amino acid
C2U40_15585	COG1234	tRNA 3'-trailer cleavage
C2U40_15590	COG0814	amino acid
C2U40_15605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U40_15610	COG1982	Orn Lys Arg decarboxylase major
C2U40_15615	COG0531	amino acid
C2U40_15620	COG3710	Transcriptional regulator
C2U40_15625	COG0825	malonyl-CoA metabolic process
C2U40_15635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U40_15640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_15645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_15650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U40_15655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_15670	COG0750	zinc metalloprotease
C2U40_15675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U40_15680	COG0575	Belongs to the CDS family
C2U40_15690	COG0233	cytoplasmic translational termination
C2U40_15695	COG0528	UMP kinase activity
C2U40_15700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U40_15705	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U40_15710	COG0024	Methionine aminopeptidase
C2U40_15715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U40_15720	COG2171	N-acyltransferase activity
C2U40_15730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_15730	COG1263	PTS System
C2U40_15750	COG0564	pseudouridine synthase activity
C2U40_15755	COG3098	single-species biofilm formation
C2U40_15780	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U40_15790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U40_15790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U40_15800	COG3706	GGDEF domain
C2U40_15805	COG1611	Belongs to the LOG family
C2U40_15810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_15815	COG0473	3-isopropylmalate dehydrogenase activity
C2U40_15825	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U40_15830	COG2363	Small membrane protein
C2U40_15840	COG0583	DNA-binding transcription factor activity
C2U40_15845	COG0840	transmembrane signaling receptor activity
C2U40_15850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_15865	COG1477	protein flavinylation
C2U40_15870	COG2871	sodium ion transport
C2U40_15875	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_15880	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_15885	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_15890	COG1805	sodium ion transport
C2U40_15895	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_15900	COG0271	Belongs to the BolA IbaG family
C2U40_15905	COG2813	Specifically methylates the guanine in position
C2U40_15915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U40_15925	COG2211	Major facilitator Superfamily
C2U40_15930	COG3248	Nucleoside-binding outer membrane protein
C2U40_15935	COG1666	GTP binding
C2U40_15940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U40_15945	COG0693	protein deglycase activity
C2U40_15990	COG3501	Rhs element vgr protein
C2U40_16005	COG2771	luxR family
C2U40_16075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_16075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_16080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U40_16090	COG1151	hydroxylamine reductase activity
C2U40_16095	COG0783	Belongs to the Dps family
C2U40_16120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U40_16135	COG4221	oxidoreductase activity
C2U40_16145	COG0415	Belongs to the DNA photolyase family
C2U40_16385	COG2842	Transposition protein
C2U40_16410	COG3272	Protein of unknown function (DUF1722)
C2U40_16440	COG0077	Prephenate dehydratase
C2U40_16440	COG1605	Chorismate mutase
C2U40_16470	COG5377	YqaJ viral recombinase family
C2U40_16500	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_16540	COG2003	Belongs to the UPF0758 family
C2U40_16580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U40_16645	COG2133	pyrroloquinoline quinone binding
C2U40_16665	COG0300	oxidoreductase activity
C2U40_16690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U40_16705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U40_16725	COG0826	peptidase U32
C2U40_16730	COG1280	lysine exporter protein (LysE YggA)
C2U40_16745	COG0840	transmembrane signaling receptor activity
C2U40_16750	COG0745	RESPONSE REGULATOR receiver
C2U40_16760	COG0643	Histidine kinase
C2U40_16760	COG2198	Histidine kinase
C2U40_16770	COG0835	chemotaxis
C2U40_16775	COG0840	transmembrane signaling receptor activity
C2U40_16785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2U40_16790	COG2201	protein-glutamate methylesterase activity
C2U40_16795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U40_16825	COG2197	response regulator
C2U40_16835	COG3188	usher protein
C2U40_16850	COG2199	diguanylate cyclase activity
C2U40_16850	COG2200	EAL domain
C2U40_16850	COG2203	Gaf domain
C2U40_16860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_16870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_16875	COG0305	Participates in initiation and elongation during chromosome replication
C2U40_16890	COG2200	EAL domain
C2U40_16895	COG0737	Belongs to the 5'-nucleotidase family
C2U40_16915	COG2204	response regulator
C2U40_16920	COG3385	transposase activity
C2U40_16925	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U40_16935	COG2900	Belongs to the SlyX family
C2U40_16940	COG3385	transposase activity
C2U40_16945	COG1047	Peptidyl-prolyl cis-trans
C2U40_16950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U40_16960	COG0835	chemotaxis
C2U40_16960	COG0784	Response regulator, receiver
C2U40_16965	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U40_16970	COG2203	Gaf domain
C2U40_16970	COG5001	Diguanylate cyclase
C2U40_16970	COG4251	negative regulation of phosphorylation
C2U40_16970	COG3706	GGDEF domain
C2U40_16975	COG3089	Belongs to the UPF0270 family
C2U40_16985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U40_16990	COG0463	Glycosyl transferase, family 2
C2U40_16995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U40_16995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U40_17000	COG0726	polysaccharide deacetylase
C2U40_17005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U40_17010	COG2076	Multidrug Resistance protein
C2U40_17015	COG2076	Multidrug Resistance protein
C2U40_17020	COG3954	Phosphoribulokinase
C2U40_17035	COG1765	OsmC-like protein
C2U40_17040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U40_17045	COG2226	methyltransferase
C2U40_17050	COG3397	chitin binding
C2U40_17065	COG2202	Pas domain
C2U40_17065	COG2205	protein histidine kinase activity
C2U40_17075	COG3655	Transcriptional regulator
C2U40_17080	COG2814	Major facilitator Superfamily
C2U40_17090	COG4771	TonB-dependent receptor
C2U40_17110	COG0748	coenzyme F420 binding
C2U40_17115	COG3721	Heme iron utilization protein
C2U40_17125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_17150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U40_17155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_17160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2U40_17180	COG0741	lytic transglycosylase activity
C2U40_17185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U40_17205	COG0488	(ABC) transporter
C2U40_17215	COG2252	PERMEase
C2U40_17220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U40_17225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U40_17230	COG3178	'Phosphotransferase
C2U40_17235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U40_17245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U40_17250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U40_17260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U40_17275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U40_17280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_17295	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_17305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U40_17310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U40_17315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U40_17320	COG0142	geranyltranstransferase activity
C2U40_17325	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U40_17330	COG0330	HflC and HflK could
C2U40_17335	COG0330	HflC and HflK could
C2U40_17340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U40_17345	COG1923	regulation of RNA biosynthetic process
C2U40_17350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U40_17355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U40_17365	COG0802	atpase or kinase
C2U40_17370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U40_17370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U40_17375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U40_17390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U40_17395	COG2011	ABC-type metal ion transport system permease component
C2U40_17400	COG1464	Belongs to the NlpA lipoprotein family
C2U40_17410	COG0840	transmembrane signaling receptor activity
C2U40_17435	COG5002	protein histidine kinase activity
C2U40_17435	COG0784	Response regulator, receiver
C2U40_17435	COG2198	Histidine kinase
C2U40_17455	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U40_17470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U40_17475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U40_17485	COG2716	regulation of RNA biosynthetic process
C2U40_17490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U40_17495	COG3013	Belongs to the UPF0304 family
C2U40_17500	COG3092	negative regulation of chromosome organization
C2U40_17505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U40_17510	COG0280	phosphate acetyltransferase
C2U40_17510	COG0857	belongs to the CobB CobQ family
C2U40_17525	COG0028	Belongs to the TPP enzyme family
C2U40_17535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U40_17540	COG0671	phosphoesterase, PA-phosphatase related
C2U40_17550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U40_17555	COG0473	3-isopropylmalate dehydrogenase activity
C2U40_17560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U40_17565	COG0066	3-isopropylmalate dehydratase activity
C2U40_17580	COG4143	(ABC) transporter
C2U40_17585	COG1178	ABC-type Fe3 transport system permease component
C2U40_17590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U40_17595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U40_17605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_17635	COG0316	Belongs to the HesB IscA family
C2U40_17645	COG0038	chloride channel
C2U40_17650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U40_17665	COG0671	phosphoesterase, PA-phosphatase related
C2U40_17680	COG0784	Response regulator, receiver
C2U40_17680	COG3437	response regulator, receiver
C2U40_17690	COG2076	Multidrug Resistance protein
C2U40_17700	COG0346	lactoylglutathione lyase activity
C2U40_17705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_17710	COG1643	Atp-dependent helicase
C2U40_17720	COG1489	DNA binding
C2U40_17725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U40_17730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_17745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U40_17750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U40_17770	COG1924	4 iron, 4 sulfur cluster binding
C2U40_17775	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2U40_17780	COG0842	Transport permease protein
C2U40_17785	COG1131	(ABC) transporter
C2U40_17800	COG0163	prenyltransferase activity
C2U40_17805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U40_17810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U40_17835	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U40_17870	COG0840	transmembrane signaling receptor activity
C2U40_17890	COG0529	Catalyzes the synthesis of activated sulfate
C2U40_17895	COG0471	metal ion transport
C2U40_17895	COG3273	potassium ion transport
C2U40_17900	COG2895	sulfate adenylyltransferase (ATP) activity
C2U40_17905	COG0175	sulfate reduction
C2U40_17910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U40_17910	COG1648	precorrin-2 dehydrogenase activity
C2U40_17915	COG0330	HflC and HflK could
C2U40_17920	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U40_17925	COG0517	IMP dehydrogenase activity
C2U40_17925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U40_17930	COG0488	(ABC) transporter
C2U40_17940	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U40_17945	COG0583	DNA-binding transcription factor activity
C2U40_17990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U40_18000	COG0668	transmembrane transport
C2U40_18010	COG2731	YhcH YjgK YiaL family protein
C2U40_18020	COG2132	Multicopper oxidase
C2U40_18025	COG1794	racemase activity, acting on amino acids and derivatives
C2U40_18035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_18060	COG0733	neurotransmitter:sodium symporter activity
C2U40_18070	COG0733	neurotransmitter:sodium symporter activity
C2U40_18085	COG0561	phosphatase activity
C2U40_18115	COG1846	Transcriptional regulator
C2U40_18120	COG1764	response to oxidative stress
C2U40_18125	COG2130	NADP-dependent
C2U40_18130	COG1051	belongs to the nudix hydrolase family
C2U40_18150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U40_18155	COG1640	4-alpha-glucanotransferase
C2U40_18160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U40_18165	COG0676	glucose-6-phosphate 1-epimerase activity
C2U40_18170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U40_18175	COG0840	transmembrane signaling receptor activity
C2U40_18250	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U40_18255	COG2885	chlorophyll binding
C2U40_18260	COG0823	Involved in the tonB-independent uptake of proteins
C2U40_18275	COG0811	peptide transport
C2U40_18280	COG0824	Thioesterase
C2U40_18285	COG3790	cyd operon protein YbgE
C2U40_18290	COG4890	Cyd operon protein YbgT
C2U40_18295	COG1294	oxidase, subunit
C2U40_18300	COG1271	oxidase subunit
C2U40_18305	COG2255	four-way junction helicase activity
C2U40_18310	COG0632	four-way junction helicase activity
C2U40_18315	COG0840	transmembrane signaling receptor activity
C2U40_18320	COG0442	prolyl-tRNA aminoacylation
C2U40_18325	COG4221	oxidoreductase activity
C2U40_18340	COG1024	Enoyl-CoA hydratase
C2U40_18360	COG4166	transmembrane transport
C2U40_18375	COG1872	DUF167
C2U40_18380	COG0762	integral membrane protein
C2U40_18385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U40_18390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U40_18405	COG3022	response to hydroperoxide
C2U40_18410	COG0513	Belongs to the DEAD box helicase family
C2U40_18415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U40_18440	COG0735	belongs to the Fur family
C2U40_18445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U40_18460	COG0776	regulation of translation
C2U40_18465	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U40_18490	COG0560	Phosphoserine phosphatase
C2U40_18500	COG3447	MASE1 domain protein
C2U40_18500	COG5001	Diguanylate cyclase
C2U40_18500	COG5002	protein histidine kinase activity
C2U40_18505	COG0813	purine-nucleoside phosphorylase activity
C2U40_18510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U40_18515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U40_18520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U40_18530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_18535	COG0084	hydrolase, TatD family'
C2U40_18550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_18555	COG0004	ammonium transporteR
C2U40_18560	COG4974	Belongs to the 'phage' integrase family
C2U40_18570	COG1396	sequence-specific DNA binding
C2U40_18650	COG4680	protein conserved in bacteria
C2U40_18655	COG5499	transcription regulator containing HTH domain
C2U40_18665	COG4695	Portal protein
C2U40_18720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U40_18800	COG0795	lipopolysaccharide-transporting ATPase activity
C2U40_18805	COG0795	lipopolysaccharide-transporting ATPase activity
C2U40_18810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U40_18815	COG2927	DNA polymerase III (CHI subunit)
C2U40_18820	COG0525	valine-tRNA ligase activity
C2U40_18825	COG1253	flavin adenine dinucleotide binding
C2U40_18830	COG0586	Pfam SNARE associated Golgi protein
C2U40_18835	COG1686	Belongs to the peptidase S11 family
C2U40_18870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U40_18875	COG0527	aspartate kinase activity
C2U40_18880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U40_18890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U40_18895	COG1546	Belongs to the CinA family
C2U40_18905	COG5377	YqaJ viral recombinase family
C2U40_18925	COG2003	Belongs to the UPF0758 family
C2U40_18945	COG1160	GTP binding
C2U40_18960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U40_18980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_19030	COG0582	viral genome integration into host DNA
C2U40_19035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U40_19060	COG3068	Protein conserved in bacteria
C2U40_19070	COG0739	heme binding
C2U40_19090	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U40_19095	COG1121	(ABC) transporter
C2U40_19100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U40_19105	COG0583	DNA-binding transcription factor activity
C2U40_19110	COG0697	spore germination
C2U40_19115	COG1573	uracil-dna glycosylase
C2U40_19120	COG2962	Rard protein
C2U40_19130	COG2827	Endonuclease containing a URI domain
C2U40_19145	COG1842	Phage shock protein A
C2U40_19150	COG0204	Acyl-transferase
C2U40_19170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U40_19210	COG0187	DNA topoisomerase II activity
C2U40_19215	COG1289	transmembrane transporter activity
C2U40_19220	COG1566	PFAM secretion protein HlyD family protein
C2U40_19235	COG1051	belongs to the nudix hydrolase family
C2U40_19240	COG3150	esterase
C2U40_19250	COG3151	Protein conserved in bacteria
C2U40_19255	COG0494	nUDIX hydrolase
C2U40_19260	COG1538	Outer membrane efflux protein
C2U40_19265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U40_19265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U40_19270	COG1560	Kdo2-lipid A biosynthetic process
C2U40_19285	COG1392	Phosphate transport regulator
C2U40_19290	COG0306	phosphate transporter
C2U40_19295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U40_19325	COG0583	DNA-binding transcription factor activity
C2U40_19330	COG1380	Effector of murein hydrolase LrgA
C2U40_19335	COG1346	cytolysis
C2U40_19350	COG0617	tRNA 3'-terminal CCA addition
C2U40_19355	COG3267	Type II secretory pathway component ExeA
C2U40_19355	COG3409	Peptidoglycan-binding domain 1 protein
C2U40_19365	COG1194	a g-specific adenine glycosylase
C2U40_19370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U40_19380	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U40_19385	COG3240	lipase activity
C2U40_19395	COG2885	chlorophyll binding
C2U40_19395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U40_19400	COG3009	Protein conserved in bacteria
C2U40_19405	COG3008	intermembrane lipid transfer
C2U40_19405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U40_19410	COG2995	paraquat-inducible protein a
C2U40_19420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_19430	COG2203	Gaf domain
C2U40_19430	COG4251	negative regulation of phosphorylation
C2U40_19430	COG3706	GGDEF domain
C2U40_19430	COG5001	Diguanylate cyclase
C2U40_19435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U40_19440	COG2813	Specifically methylates the guanine in position
C2U40_19445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U40_19450	COG0297	glycogen (starch) synthase activity
C2U40_19490	COG1757	Na H antiporter
C2U40_19495	COG0583	DNA-binding transcription factor activity
C2U40_19500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U40_19505	COG3842	ATPase activity
C2U40_19510	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U40_19515	COG1177	transmembrane transport
C2U40_19520	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_19585	COG5006	permease, DMT superfamily
C2U40_19590	COG1522	sequence-specific DNA binding
C2U40_19595	COG0110	maltose O-acetyltransferase activity
C2U40_19600	COG0366	Alpha amylase catalytic
C2U40_19605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_19605	COG1263	PTS System
C2U40_19625	COG0252	asparaginase activity
C2U40_19640	COG1803	Methylglyoxal synthase
C2U40_19665	COG1444	tRNA N-acetyltransferase activity
C2U40_19675	COG0784	Response regulator, receiver
C2U40_19675	COG0835	chemotaxis
C2U40_19720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U40_19725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U40_19740	COG0477	Major facilitator Superfamily
C2U40_19745	COG0523	cobalamin synthesis protein
C2U40_19755	COG1280	lysine exporter protein (LysE YggA)
C2U40_19765	COG2200	EAL domain
C2U40_19770	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U40_19775	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U40_19780	COG0840	transmembrane signaling receptor activity
C2U40_19785	COG0840	transmembrane signaling receptor activity
C2U40_19795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U40_19800	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U40_19805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U40_19810	COG2186	Transcriptional regulator
C2U40_19840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_19845	COG1459	type II secretion system
C2U40_19860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U40_19865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U40_19870	COG0494	nUDIX hydrolase
C2U40_19880	COG0653	protein targeting
C2U40_19890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U40_19895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U40_19900	COG0849	cell division
C2U40_19905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U40_19910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U40_19915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U40_19920	COG0772	Belongs to the SEDS family
C2U40_19925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U40_19930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U40_19935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U40_19940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U40_19945	COG0768	penicillin binding
C2U40_19950	COG3116	cell division
C2U40_19955	COG0275	rRNA processing
C2U40_19960	COG2001	Belongs to the MraZ family
C2U40_19970	COG0741	lytic transglycosylase activity
C2U40_19970	COG1388	LysM domain
C2U40_19980	COG1360	Flagellar Motor Protein
C2U40_19985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_19990	COG1191	sigma factor activity
C2U40_20015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U40_20020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U40_20035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U40_20040	COG4786	Flagellar basal body rod
C2U40_20040	COG1256	bacterial-type flagellum assembly
C2U40_20050	COG1706	bacterial-type flagellum-dependent cell motility
C2U40_20055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U40_20060	COG4786	Flagellar basal body rod
C2U40_20070	COG1749	Flagellar hook protein flgE
C2U40_20075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2U40_20080	COG1558	bacterial-type flagellum-dependent cell motility
C2U40_20085	COG1815	bacterial-type flagellum-dependent cell motility
C2U40_20120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U40_20130	COG1677	Flagellar hook-basal body complex protein FliE
C2U40_20135	COG2204	response regulator
C2U40_20180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U40_20185	COG3107	peptidoglycan biosynthetic process
C2U40_20190	COG0792	nuclease activity
C2U40_20195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U40_20200	COG2823	Periplasmic or secreted lipoprotein
C2U40_20210	COG2969	positive regulation of protein catabolic process
C2U40_20215	COG0625	glutathione transferase activity
C2U40_20220	COG2857	Cytochrome c1
C2U40_20225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U40_20230	COG0723	plastoquinol--plastocyanin reductase activity
C2U40_20235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U40_20240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U40_20245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U40_20255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_20260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_20290	COG3964	amidohydrolase
C2U40_20305	COG3711	transcriptional antiterminator
C2U40_20305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_20310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_20315	COG1660	Displays ATPase and GTPase activities
C2U40_20320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_20330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U40_20335	COG1137	ATPase activity
C2U40_20340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U40_20345	COG3117	lipopolysaccharide transmembrane transporter activity
C2U40_20350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U40_20355	COG0517	IMP dehydrogenase activity
C2U40_20355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U40_20360	COG1127	ABC transporter
C2U40_20365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U40_20370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U40_20375	COG2854	intermembrane phospholipid transfer
C2U40_20385	COG5007	Belongs to the BolA IbaG family
C2U40_20390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U40_20395	COG0312	modulator of DNA gyrase
C2U40_20400	COG3028	Belongs to the UPF0307 family
C2U40_20415	COG2926	Belongs to the UPF0265 family
C2U40_20450	COG1396	sequence-specific DNA binding
C2U40_20455	COG3135	benzoate transporter
C2U40_20485	COG3047	cAMP biosynthetic process
C2U40_20490	COG3706	GGDEF domain
C2U40_20495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U40_20500	COG2197	response regulator
C2U40_20505	COG0629	single-stranded DNA binding
C2U40_20530	COG1278	Cold shock
C2U40_20535	COG4771	TonB-dependent receptor
C2U40_20540	COG3706	GGDEF domain
C2U40_20540	COG2203	Gaf domain
C2U40_20540	COG5001	Diguanylate cyclase
C2U40_20540	COG4251	negative regulation of phosphorylation
C2U40_20550	COG0745	RESPONSE REGULATOR receiver
C2U40_20590	COG0346	lactoylglutathione lyase activity
C2U40_20600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U40_20605	COG1074	ATP-dependent DNA helicase activity
C2U40_20610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U40_20615	COG2259	Doxx family
C2U40_20620	COG1741	Belongs to the pirin family
C2U40_20630	COG0583	DNA-binding transcription factor activity
C2U40_20660	COG1175	transmembrane transport
C2U40_20670	COG3842	ATPase activity
C2U40_20680	COG2199	diguanylate cyclase activity
C2U40_20680	COG2203	Gaf domain
C2U40_20700	COG1247	-acetyltransferase
C2U40_20705	COG0753	catalase activity
C2U40_20730	COG0494	nUDIX hydrolase
C2U40_20735	COG0628	permease
C2U40_20760	COG2957	Belongs to the agmatine deiminase family
C2U40_20770	COG3284	Transcriptional regulator
C2U40_20785	COG1461	Dihydroxyacetone kinase
C2U40_20790	COG2376	Dihydroxyacetone kinase
C2U40_20795	COG2252	PERMEase
C2U40_20835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U40_20840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U40_20845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U40_20850	COG0049	tRNA binding
C2U40_20855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U40_20860	COG2168	tRNA wobble position uridine thiolation
C2U40_20865	COG2923	Belongs to the DsrF TusC family
C2U40_20870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U40_20875	COG0251	oxidation-reduction process
C2U40_20880	COG2964	Protein conserved in bacteria
C2U40_20885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U40_20890	COG0085	RNA polymerase activity
C2U40_20895	COG0222	ribosome binding
C2U40_20900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U40_20905	COG0081	regulation of translation
C2U40_20910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U40_20915	COG0250	Participates in transcription elongation, termination and antitermination
C2U40_20920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U40_20930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U40_20955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U40_20960	COG0569	domain protein
C2U40_20965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_20985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U40_20990	COG3005	denitrification pathway
C2U40_20995	COG0243	molybdopterin cofactor binding
C2U40_21005	COG2205	protein histidine kinase activity
C2U40_21010	COG0745	RESPONSE REGULATOR receiver
C2U40_21025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2U40_21045	COG2204	response regulator
C2U40_21055	COG2205	protein histidine kinase activity
C2U40_21080	COG5413	integral membrane protein
C2U40_21090	COG1522	sequence-specific DNA binding
C2U40_21095	COG2502	aspartate--ammonia ligase
C2U40_21105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U40_21110	COG0542	response to heat
C2U40_21120	COG0564	pseudouridine synthase activity
C2U40_21125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_21130	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_21140	COG3681	Belongs to the UPF0597 family
C2U40_21150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U40_21155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U40_21160	COG1979	alcohol dehydrogenase
C2U40_21175	COG3423	Transcriptional regulator
C2U40_21185	COG2842	Transposition protein
C2U40_21415	COG3040	lipid binding
C2U40_21425	COG0688	phosphatidylethanolamine metabolic process
C2U40_21440	COG0540	Belongs to the ATCase OTCase family
C2U40_21445	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U40_21450	COG1438	arginine binding
C2U40_21455	COG1288	antiporter activity
C2U40_21460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U40_21505	COG3250	beta-galactosidase activity
C2U40_21510	COG1609	Transcriptional regulator
C2U40_21515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U40_21525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U40_21530	COG2017	converts alpha-aldose to the beta-anomer
C2U40_21535	COG0667	Aldo Keto reductase
C2U40_21540	COG1968	undecaprenyl-diphosphatase activity
C2U40_21545	COG3806	Anti-sigma factor
C2U40_21550	COG1595	DNA-templated transcription, initiation
C2U40_21570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U40_21575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U40_21580	COG0477	Major facilitator Superfamily
C2U40_21595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_21600	COG1131	(ABC) transporter
C2U40_21605	COG0842	Transport permease protein
C2U40_21610	COG0842	Transport permease protein
C2U40_21615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U40_21620	COG2146	nitrite reductase [NAD(P)H] activity
C2U40_21625	COG2116	formate transmembrane transporter activity
C2U40_21630	COG1648	precorrin-2 dehydrogenase activity
C2U40_21630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U40_21635	COG2239	Acts as a magnesium transporter
C2U40_21640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U40_21645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U40_21655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U40_21665	COG0514	ATP-dependent DNA helicase (RecQ)
C2U40_21670	COG2050	protein possibly involved in aromatic compounds catabolism
C2U40_21685	COG2258	MOSC domain
C2U40_21690	COG1177	transmembrane transport
C2U40_21695	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U40_21700	COG3842	ATPase activity
C2U40_21720	COG0174	glutamine synthetase
C2U40_21725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U40_21740	COG3045	CreA protein
C2U40_21745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U40_21750	COG0443	Heat shock 70 kDa protein
C2U40_21765	COG0366	Alpha amylase catalytic
C2U40_21770	COG1086	Polysaccharide biosynthesis protein
C2U40_21775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U40_21780	COG4750	Nucleotidyl transferase
C2U40_21785	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_21790	COG0574	Belongs to the PEP-utilizing enzyme family
C2U40_21790	COG3848	Pyruvate phosphate dikinase
C2U40_21800	COG0529	Catalyzes the synthesis of activated sulfate
C2U40_21825	COG1215	transferase activity, transferring glycosyl groups
C2U40_21840	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_21845	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_21860	COG1083	cytidylyl-transferase
C2U40_21870	COG2089	acid synthase
C2U40_21890	COG4310	Domain of unknown function (DUF2172)
C2U40_21925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_21930	COG0745	RESPONSE REGULATOR receiver
C2U40_21935	COG2205	protein histidine kinase activity
C2U40_21945	COG0281	malic enzyme
C2U40_21950	COG0702	epimerase
C2U40_21955	COG0254	rRNA binding
C2U40_21960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U40_21980	COG0129	dihydroxy-acid dehydratase activity
C2U40_21985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U40_21990	COG3978	acetolactate synthase activity
C2U40_22005	COG0606	chelatase, subunit chli
C2U40_22010	COG0204	Acyl-transferase
C2U40_22015	COG0204	Acyl-transferase
C2U40_22020	COG1683	Conserved Protein
C2U40_22030	COG1335	isochorismatase
C2U40_22040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_22045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U40_22055	COG3084	Protein conserved in bacteria
C2U40_22060	COG3706	GGDEF domain
C2U40_22060	COG2203	Gaf domain
C2U40_22060	COG4251	negative regulation of phosphorylation
C2U40_22060	COG5001	Diguanylate cyclase
C2U40_22065	COG0789	Transcriptional regulator
C2U40_22075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U40_22080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U40_22085	COG1561	YicC-like family, N-terminal region
C2U40_22105	COG3306	glycosyltransferase involved in LPS biosynthesis
C2U40_22120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U40_22130	COG0156	8-amino-7-oxononanoate synthase activity
C2U40_22135	COG1063	alcohol dehydrogenase
C2U40_22140	COG3245	cytochrome
C2U40_22150	COG0210	DNA helicase
C2U40_22155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U40_22160	COG2166	iron-sulfur cluster assembly
C2U40_22165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U40_22195	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U40_22200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_22205	COG1739	Uncharacterized protein family UPF0029
C2U40_22210	COG0006	proline dipeptidase activity
C2U40_22215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U40_22220	COG1024	Enoyl-CoA hydratase
C2U40_22220	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U40_22225	COG0183	Belongs to the thiolase family
C2U40_22230	COG0745	RESPONSE REGULATOR receiver
C2U40_22235	COG2205	protein histidine kinase activity
C2U40_22250	COG0425	Belongs to the sulfur carrier protein TusA family
C2U40_22255	COG0251	oxidation-reduction process
C2U40_22260	COG2885	chlorophyll binding
C2U40_22270	COG2818	Glycosylase
C2U40_22275	COG0752	glycyl-tRNA synthetase alpha subunit
C2U40_22280	COG0751	glycine-tRNA ligase activity
C2U40_22325	COG3385	transposase activity
C2U40_22335	COG0814	amino acid
C2U40_22340	COG0348	domain, Protein
C2U40_22350	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_22355	COG0426	domain, Protein
C2U40_22355	COG1773	rubredoxin
C2U40_22360	COG3604	Transcriptional regulator
C2U40_22365	COG2188	Transcriptional regulator
C2U40_22380	COG1609	Transcriptional regulator
C2U40_22390	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U40_22420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_22445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U40_22455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U40_22460	COG3118	belongs to the thioredoxin family
C2U40_22465	COG0513	Belongs to the DEAD box helicase family
C2U40_22470	COG0248	Ppx GppA phosphatase
C2U40_22485	COG0742	ribosomal rna small subunit methyltransferase
C2U40_22505	COG0084	hydrolase, TatD family'
C2U40_22510	COG0805	protein transport
C2U40_22515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U40_22525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U40_22530	COG3165	ubiquinone biosynthetic process from chorismate
C2U40_22540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U40_22545	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_22585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U40_22590	COG0848	biopolymer transport protein
C2U40_22595	COG0811	peptide transport
C2U40_22600	COG0811	peptide transport
C2U40_22610	COG2771	luxR family
C2U40_22615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_22635	COG0732	type I restriction modification DNA specificity domain
C2U40_22640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_22675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U40_22680	COG1349	DNA-binding transcription factor activity
C2U40_22685	COG0745	RESPONSE REGULATOR receiver
C2U40_22690	COG2205	protein histidine kinase activity
C2U40_22700	COG4452	Inner membrane protein CreD
C2U40_22705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U40_22710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U40_22715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U40_22720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U40_22725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U40_22730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U40_22735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U40_22745	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U40_22755	COG1475	DNA binding
C2U40_22760	COG1192	Involved in chromosome partitioning
C2U40_22765	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U40_22770	COG0445	tRNA wobble uridine modification
C2U40_22775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U40_22780	COG4774	siderophore transport
C2U40_22785	COG4615	Cyclic peptide transporter
C2U40_22790	COG1120	ATPase activity
C2U40_22810	COG3550	peptidyl-serine autophosphorylation
C2U40_22835	COG4584	PFAM Integrase catalytic
C2U40_22840	COG1484	DNA-dependent DNA replication
C2U40_22870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_22870	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U40_22905	COG4974	Belongs to the 'phage' integrase family
C2U40_22910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U40_22915	COG0706	membrane insertase activity
C2U40_22920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U40_22925	COG0594	ribonuclease P activity
C2U40_22930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U40_22950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U40_22955	COG0592	DNA-directed DNA polymerase activity
C2U40_22965	COG0187	DNA topoisomerase II activity
C2U40_22980	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U40_22985	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U40_22990	COG3977	Valine--pyruvate aminotransferase
C2U40_23005	COG2814	Major facilitator Superfamily
C2U40_23010	COG0745	RESPONSE REGULATOR receiver
C2U40_23015	COG2205	protein histidine kinase activity
C2U40_23040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U40_23045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_23045	COG4191	Histidine kinase
C2U40_23050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_23055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_23090	COG0561	phosphatase activity
C2U40_23095	COG2267	carboxylic ester hydrolase activity
C2U40_23100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U40_23105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U40_23110	COG1758	RNA polymerase activity
C2U40_23120	COG0859	PFAM glycosyl transferase family 9
C2U40_23125	COG3642	lipopolysaccharide core region biosynthetic process
C2U40_23165	COG0589	response to stress
C2U40_23170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U40_23175	COG2199	diguanylate cyclase activity
C2U40_23180	COG1528	Iron-storage protein
C2U40_23185	COG2081	HI0933 family
C2U40_23190	COG2223	nitrite transmembrane transporter activity
C2U40_23210	COG3188	usher protein
C2U40_23230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_23230	COG2205	protein histidine kinase activity
C2U40_23240	COG3275	phosphorelay sensor kinase activity
C2U40_23245	COG3279	Response regulator of the LytR AlgR family
C2U40_23250	COG2223	nitrite transmembrane transporter activity
C2U40_23255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U40_23260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U40_23275	COG0583	DNA-binding transcription factor activity
C2U40_23280	COG4206	TonB-dependent receptor
C2U40_23285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U40_23315	COG1042	CoA-binding domain protein
C2U40_23315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_23315	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U40_23330	COG0583	DNA-binding transcription factor activity
C2U40_23335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U40_23340	COG0166	Belongs to the GPI family
C2U40_23355	COG0668	transmembrane transport
C2U40_23360	COG1309	transcriptional regulator
C2U40_23365	COG0756	dUTP diphosphatase activity
C2U40_23370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U40_23375	COG2003	Belongs to the UPF0758 family
C2U40_23380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U40_23385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U40_23395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U40_23400	COG2990	Protein conserved in bacteria
C2U40_23405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U40_23410	COG0859	PFAM glycosyl transferase family 9
C2U40_23415	COG0463	Glycosyl transferase, family 2
C2U40_23420	COG0859	PFAM glycosyl transferase family 9
C2U40_23425	COG1519	Transferase
C2U40_23445	COG1609	Transcriptional regulator
C2U40_23450	COG0604	alcohol dehydrogenase
C2U40_23470	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U40_23475	COG3161	chorismate lyase activity
C2U40_23480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U40_23485	COG2937	Belongs to the GPAT DAPAT family
C2U40_23490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U40_23515	COG0534	Mate efflux family protein
C2U40_23520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U40_23525	COG2205	protein histidine kinase activity
C2U40_23530	COG0745	RESPONSE REGULATOR receiver
C2U40_23540	COG1045	serine acetyltransferase
C2U40_23550	COG3074	FtsZ-dependent cytokinesis
C2U40_23555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U40_23565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_23565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_23570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U40_23610	COG1609	Transcriptional regulator
C2U40_23615	COG3250	beta-galactosidase activity
C2U40_23620	COG2731	YhcH YjgK YiaL family protein
C2U40_23625	COG0531	amino acid
C2U40_23630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_23635	COG0531	amino acid
C2U40_23640	COG0385	Bile acid
C2U40_23645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U40_23665	COG0583	DNA-binding transcription factor activity
C2U40_23690	COG0210	DNA helicase
C2U40_23700	COG1943	Transposase
C2U40_23705	COG0583	DNA-binding transcription factor activity
C2U40_23760	COG1280	lysine exporter protein (LysE YggA)
C2U40_23770	COG2391	methyltransferase activity
C2U40_23775	COG0840	transmembrane signaling receptor activity
C2U40_23785	COG1280	lysine exporter protein (LysE YggA)
C2U40_23795	COG2962	Rard protein
C2U40_23805	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_23810	COG1396	sequence-specific DNA binding
C2U40_23825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U40_23825	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_23830	COG0686	Belongs to the AlaDH PNT family
C2U40_23835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_23855	COG1322	Protein conserved in bacteria
C2U40_23860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_23865	COG0569	domain protein
C2U40_23870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_23870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_23875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U40_23880	COG0242	peptide deformylase activity
C2U40_23890	COG0758	DNA mediated transformation
C2U40_23895	COG2922	Belongs to the Smg family
C2U40_23900	COG0551	DNA topoisomerase type I activity
C2U40_23910	COG0009	L-threonylcarbamoyladenylate synthase
C2U40_23915	COG0408	coproporphyrinogen oxidase activity
C2U40_23920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U40_23930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U40_23945	COG3078	GTPase activator activity
C2U40_23955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U40_23960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U40_23965	COG2204	response regulator
C2U40_23970	COG3852	Histidine kinase
C2U40_23980	COG0174	glutamine synthetase
C2U40_23995	COG1295	ribonuclease BN
C2U40_24000	COG1490	D-aminoacyl-tRNA deacylase activity
C2U40_24010	COG0456	acetyltransferase
C2U40_24020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U40_24025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_24030	COG2610	gluconate transmembrane transporter activity
C2U40_24035	COG3265	gluconokinase activity
C2U40_24040	COG0129	dihydroxy-acid dehydratase activity
C2U40_24045	COG0800	Aldolase
C2U40_24050	COG1609	Transcriptional regulator
C2U40_24060	COG4942	peptidase
C2U40_24065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U40_24070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_24075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U40_24080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U40_24085	COG0316	Belongs to the HesB IscA family
C2U40_24085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U40_24090	COG1040	competence protein
C2U40_24095	COG0596	Alpha beta hydrolase
C2U40_24115	COG2183	response to ionizing radiation
C2U40_24120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U40_24125	COG0745	RESPONSE REGULATOR receiver
C2U40_24140	COG0051	transcription antitermination factor activity, RNA binding
C2U40_24145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U40_24150	COG0088	Forms part of the polypeptide exit tunnel
C2U40_24155	COG0089	rRNA binding
C2U40_24160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U40_24165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U40_24170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U40_24175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U40_24180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U40_24185	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U40_24190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U40_24195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U40_24200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U40_24205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U40_24210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U40_24215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U40_24220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U40_24225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U40_24230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U40_24235	COG1841	ribosomal large subunit assembly
C2U40_24240	COG0200	Binds to the 23S rRNA
C2U40_24245	COG0201	protein transport
C2U40_24250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U40_24255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U40_24260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U40_24265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U40_24270	COG0202	RNA polymerase activity
C2U40_24275	COG0203	ribosomal protein L17
C2U40_24335	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U40_24340	COG0583	DNA-binding transcription factor activity
C2U40_24345	COG4221	oxidoreductase activity
C2U40_24360	COG1770	oligopeptidase
C2U40_24385	COG3714	YhhN family
C2U40_24410	COG1301	dicarboxylic acid transport
C2U40_24420	COG2095	MarC family integral membrane protein
C2U40_24440	COG0741	lytic transglycosylase activity
C2U40_24445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_24475	COG0742	ribosomal rna small subunit methyltransferase
C2U40_24480	COG0552	protein localization to endoplasmic reticulum
C2U40_24485	COG2884	Cell division ATP-binding protein ftsE
C2U40_24490	COG2177	Part of the ABC transporter FtsEX involved in
C2U40_24500	COG0288	reversible hydration of carbon dioxide
C2U40_24505	COG2188	Transcriptional regulator
C2U40_24510	COG1228	amidohydrolase
C2U40_24515	COG0010	Belongs to the arginase family
C2U40_24520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U40_24525	COG2986	histidine ammonia-lyase
C2U40_24530	COG0387	Pfam Sodium calcium exchanger
C2U40_24535	COG2200	EAL domain
C2U40_24540	COG2199	diguanylate cyclase activity
C2U40_24540	COG2200	EAL domain
C2U40_24715	COG2176	DNA-directed DNA polymerase activity
C2U40_24715	COG5002	protein histidine kinase activity
C2U40_24815	COG3385	transposase activity
C2U40_24835	COG1192	Involved in chromosome partitioning
C2U40_24840	COG3077	Addiction module antitoxin, RelB DinJ family
C2U40_24845	COG2026	Addiction module toxin, RelE StbE family
C2U40_24960	COG5002	protein histidine kinase activity
C2U40_24960	COG2176	DNA-directed DNA polymerase activity
C2U40_25030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_25060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_25075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U40_25115	COG1192	Involved in chromosome partitioning
C2U40_25130	COG0840	transmembrane signaling receptor activity
C2U40_25190	COG3316	Transposase and inactivated derivatives
C2U40_25210	COG0840	transmembrane signaling receptor activity
C2U40_25245	COG3385	transposase activity
C2U40_25465	COG0592	DNA-directed DNA polymerase activity
C2U40_25875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U40_25890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs