locus-tag class description C2U30_00015 ENOG4105CJW magnesium transporter C2U30_00020 ENOG4105C9X ppx gppa phosphatase C2U30_00025 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C2U30_00030 ENOG4105RH4 Glycine cleavage system transcriptional repressor C2U30_00040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U30_00045 ENOG4105BZU Histidine kinase C2U30_00050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U30_00055 ENOG4107QNR UPF0135 protein C2U30_00060 ENOG4108V3E phosphoribosylglycinamide formyltransferase C2U30_00065 ENOG4105CXB phosphoribosylaminoimidazole synthetase C2U30_00070 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C2U30_00085 ENOG4108I9X Isocitrate lyase C2U30_00090 ENOG4107QP3 malate synthase g C2U30_00105 ENOG4108Z6B deaminase C2U30_00110 ENOG4105C8U phosphate abc transporter C2U30_00115 ENOG4105E2Z phosphate ABC transporter (Permease C2U30_00120 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2U30_00130 ENOG4105C37 (CBS) domain C2U30_00140 ENOG4105C3R Methionine synthase C2U30_00145 ENOG4105D5Q Arginine ornithine antiporter C2U30_00155 ENOG4105CDA abc transporter atp-binding protein C2U30_00160 ENOG4105E5Q amino acid AbC transporter C2U30_00165 ENOG4106TNF Periplasmic binding protein C2U30_00175 ENOG4105BZU Histidine kinase C2U30_00180 ENOG4105NXH GreA GreB family elongation factor C2U30_00200 ENOG4105G6Z alkaline phosphatase C2U30_00205 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C2U30_00210 ENOG4108ISG Major Facilitator C2U30_00215 ENOG4105DGU Histone deacetylase C2U30_00225 ENOG4105DVT helicase C2U30_00240 ENOG4105CGF Aromatic amino acid aminotransferase C2U30_00245 ENOG4105D7A ATP-binding protein C2U30_00260 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 C2U30_00265 ENOG4105BZ1 (ABC) transporter C2U30_00270 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C2U30_00275 ENOG4105W49 UPF0434 protein C2U30_00280 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C2U30_00285 ENOG4105WH1 Two component transcriptional regulator luxr family C2U30_00290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2U30_00330 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2U30_00345 ENOG4105CBN LysR family transcriptional regulator C2U30_00350 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C2U30_00360 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family C2U30_00365 ENOG4108WUH Transcriptional regulator, TetR family C2U30_00370 ENOG4105Y3U Transglycosylase-associated protein C2U30_00375 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C2U30_00385 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C2U30_00390 ENOG4105C8N cysteinyl-tRNA synthetase C2U30_00420 ENOG4108J1Q C2U30_00435 ENOG410620I Diguanylate cyclase C2U30_00475 ENOG4108ZJT translation initiation factor, Sui1 C2U30_00485 ENOG4105CE1 Ferrous iron transport protein b C2U30_00495 ENOG4105CZX twitching motility protein C2U30_00510 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) C2U30_00515 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) C2U30_00525 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U30_00530 ENOG41080IJ Diacylglycerol kinase C2U30_00535 ENOG4108JQ1 Dehydrogenase C2U30_00540 ENOG4105E66 phosphoriboisomerase A C2U30_00545 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C2U30_00555 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C2U30_00560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C2U30_00565 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C2U30_00570 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2U30_00575 ENOG4106TD9 Diguanylate cyclase C2U30_00580 ENOG4107QS8 (LipO)protein C2U30_00630 ENOG4105EAB amino acid AbC transporter C2U30_00635 ENOG4105E5Q amino acid AbC transporter C2U30_00640 ENOG4105CDA abc transporter atp-binding protein C2U30_00645 ENOG4105BZ8 glutamate synthase C2U30_00650 ENOG4105CBC glutamate synthase C2U30_00655 ENOG4105N5T Radical SAM Protein C2U30_00665 ENOG4105C42 Type I secretion membrane fusion protein (HlyD C2U30_00700 ENOG4105C85 amino acid C2U30_00710 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C2U30_00715 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2U30_00720 ENOG4105DKW ABC transporter C2U30_00750 ENOG4105D01 (LipO)protein C2U30_00760 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) C2U30_00765 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U30_00775 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C2U30_00780 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C2U30_00785 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C2U30_00790 ENOG4108S3P Sporulation domain protein C2U30_00795 ENOG4108Z0T Part of a sulfur-relay system (By similarity) C2U30_00800 ENOG4105EM2 membrane C2U30_00805 ENOG4108MN8 Membrane C2U30_00815 ENOG4105CNM Receptor C2U30_00830 ENOG4105C7F AcnD-accessory protein PrpF C2U30_00835 ENOG4108I0Z Aconitate hydratase C2U30_00840 ENOG4105BZN citrate synthase C2U30_00845 ENOG4105CR4 methylisocitrate lyase C2U30_00855 ENOG4105BZU Histidine kinase C2U30_00860 ENOG4108W1A pseudouridine synthase C2U30_00870 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C2U30_00875 ENOG4105F1J Homogentisate 1,2-dioxygenase C2U30_00885 ENOG4108RXX maleylacetoacetate isomerase C2U30_00900 ENOG4105CAQ asparagine synthetase C2U30_00910 ENOG4105D4U had-superfamily hydrolase, subfamily iia C2U30_00915 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C2U30_00925 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U30_00930 ENOG4105EE5 Membrane protein terC C2U30_00945 ENOG4105CQB FAD linked oxidase domain protein C2U30_00955 ENOG4105KA0 thioesterase Superfamily protein C2U30_00975 ENOG4105CC0 LysR family Transcriptional regulator C2U30_00985 ENOG4105D3Y Na H antiporter C2U30_00990 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) C2U30_01000 ENOG4105EIY sodium-type flagellar protein motY C2U30_01015 ENOG4108K3A Glutathione S-transferase C2U30_01020 ENOG4105CYM Glutathione S-transferase C2U30_01030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U30_01035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U30_01040 ENOG4105C3U ABC transporter C2U30_01045 ENOG4105E5M Multidrug resistance protein D C2U30_01055 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C2U30_01065 ENOG4105D0A hydroxylase C2U30_01070 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C2U30_01075 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C2U30_01080 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C2U30_01085 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C2U30_01105 ENOG4108ISG Major Facilitator C2U30_01115 ENOG4105D3R alkyl hydroperoxide reductase C2U30_01120 ENOG4105W87 Cbs domain C2U30_01125 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C2U30_01130 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C2U30_01135 ENOG4105VIE preprotein translocase, subunit YajC C2U30_01140 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U30_01145 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U30_01150 ENOG4105KHC sulfurtransferase C2U30_01160 ENOG4106RZ4 Peptidase U32 C2U30_01165 ENOG4105CFP Peptidase U32 C2U30_01170 ENOG4105XPQ lipid carrier protein C2U30_01175 ENOG4105CVS RNA methyltransferase TrmH family, group 1 C2U30_01180 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C2U30_01185 ENOG4105C3J Cysteine desulfurase C2U30_01190 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C2U30_01195 ENOG4108Z4V iron-sulfur cluster assembly C2U30_01200 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) C2U30_01205 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB C2U30_01210 ENOG4108ZIT Ferredoxin, 2FE-2S C2U30_01220 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U30_01225 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C2U30_01230 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C2U30_01240 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C2U30_01245 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C2U30_01250 ENOG4105CUT histidyl-tRNA synthetase C2U30_01255 ENOG4105N21 Membrane C2U30_01260 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U30_01265 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C2U30_01270 ENOG4105VPD cellular component movement C2U30_01275 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C2U30_01280 ENOG4107QIK phosphoribosylformylglycinamidine synthase C2U30_01285 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U30_01290 ENOG4105C8S subunit m C2U30_01295 ENOG4105D65 subunit l C2U30_01300 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U30_01305 ENOG4107UFS subunit j C2U30_01310 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U30_01315 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C2U30_01320 ENOG4108IEH NADH dehydrogenase subunit g C2U30_01325 ENOG4107QIZ NADH dehydrogenase C2U30_01330 ENOG4105GKE subunit e C2U30_01335 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U30_01340 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U30_01345 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2U30_01350 ENOG4105ER2 Ompa motb domain protein C2U30_01355 ENOG4105E14 MotA TolQ exbB proton channel C2U30_01370 ENOG4105HA9 of methanol dehydrogenase type C2U30_01380 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) C2U30_01390 ENOG4105VFU Rna-binding protein C2U30_01395 ENOG4107RGM aldo keto reductase C2U30_01420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U30_01425 ENOG4105CBN LysR family transcriptional regulator C2U30_01435 ENOG4105BZU Histidine kinase C2U30_01440 ENOG4105CFC Transporter C2U30_01445 ENOG4108DBC nitroreductase C2U30_01470 ENOG4105D2S major facilitator superfamily C2U30_01475 ENOG4105DUM transcriptional regulator, lysR family C2U30_01480 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) C2U30_01485 ENOG4105CAT Cytidine monophosphate kinase C2U30_01490 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C2U30_01495 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C2U30_01505 ENOG4105CFV Tetratricopeptide repeat protein C2U30_01510 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C2U30_01525 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C2U30_01530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C2U30_01535 ENOG4105VRT cytoplasmic protein C2U30_01540 ENOG4108WBT adenosyltransferase C2U30_01550 ENOG4107S6Z Na H antiporter C2U30_01555 ENOG4107104 thymidine kinase C2U30_01565 ENOG4108RMJ sensory transduction regulator C2U30_01580 ENOG4106KNT transcriptional regulator C2U30_01585 ENOG4105C5Y PTS System C2U30_01590 ENOG4105CS2 ec 3.2.1.21 C2U30_01605 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) C2U30_01625 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C2U30_01640 ENOG4108RYK Nad-dependent epimerase dehydratase C2U30_01645 ENOG4105CR8 Transcriptional regulator C2U30_01650 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C2U30_01655 ENOG4105BZU Histidine kinase C2U30_01660 ENOG4105BZU Histidine kinase C2U30_01665 ENOG4105E0K tonB-dependent siderophore receptor C2U30_01675 ENOG4105DZ2 Transcriptional regulator C2U30_01680 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2U30_01690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U30_01705 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U30_01710 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein C2U30_01720 ENOG41061WM D-Alanyl-D-Alanine C2U30_01725 ENOG4108DMF Cytochrome C biogenesis protein C2U30_01730 ENOG4107QX9 Thiol disulfide interChange protein C2U30_01740 ENOG4105DVI reductase, NrfD C2U30_01745 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U30_01750 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit C2U30_01770 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U30_01775 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B C2U30_01780 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A C2U30_01790 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_01795 ENOG4105E2R ROK family C2U30_01800 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C2U30_01805 ENOG4108MRH transcriptional regulatory protein C2U30_01825 ENOG4105E4C Lytic transglycosylase catalytic C2U30_01830 ENOG4105D0C transport protein C2U30_01845 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C2U30_01855 ENOG4105DQR SNARE associated Golgi C2U30_01860 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C2U30_01865 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C2U30_01870 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) C2U30_01875 ENOG4105ED1 spovr family C2U30_01880 ENOG4106AKX UPF0229 protein C2U30_01885 ENOG4105CYN Serine protein kinase C2U30_01890 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U30_01895 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) C2U30_01900 ENOG4105C44 Serine transporter C2U30_01910 ENOG4105CRQ synthase (Component I) C2U30_01930 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) C2U30_01945 ENOG4105C8P )-transporter C2U30_01950 ENOG4105K63 Thioredoxin C2U30_01955 ENOG4105BZU Histidine kinase C2U30_01960 ENOG4105BZ1 (ABC) transporter C2U30_01965 ENOG4105BZ1 (ABC) transporter C2U30_01985 ENOG4105WQ3 Rna-binding protein C2U30_02005 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) C2U30_02010 ENOG41061CK Antibiotic biosynthesis monooxygenase C2U30_02045 ENOG4105C1J atp-dependent rna helicase C2U30_02060 ENOG4105CPF Cell wall formation (By similarity) C2U30_02065 ENOG4106IUH DTW domain containing protein C2U30_02070 ENOG4105EJ9 Membrane C2U30_02075 ENOG4105VP0 transcriptional regulator, lysR family C2U30_02090 ENOG4105CPB ATP-dependent endonuclease of the OLD family C2U30_02130 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U30_02140 ENOG4105CH2 amidohydrolase C2U30_02145 ENOG4105CTQ phosphohexokinase C2U30_02155 ENOG4107S90 membrAne C2U30_02160 ENOG4106371 Methyltransferase C2U30_02165 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) C2U30_02170 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) C2U30_02175 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) C2U30_02205 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2U30_02235 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C2U30_02270 ENOG4108DG9 Smr protein MutS2 C2U30_02275 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) C2U30_02280 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C2U30_02290 ENOG4105C1J atp-dependent rna helicase C2U30_02305 ENOG4105E0U tyrosine-specific transport protein C2U30_02310 ENOG4107B7Y DNA-binding transcriptional regulator FruR C2U30_02315 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein C2U30_02320 ENOG4105DE4 1-phosphofructokinase C2U30_02325 ENOG4105DM4 PTS System C2U30_02330 ENOG4105XZD Fe-S protein C2U30_02335 ENOG4105CA3 membrane-bound lytic murein transglycosylase C2U30_02340 ENOG4105XPH Ferredoxin C2U30_02345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U30_02350 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U30_02355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U30_02360 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C2U30_02365 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U30_02390 ENOG4105C22 threonyL-tRNA synthetase C2U30_02395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C2U30_02400 ENOG41083UC 50s ribosomal protein L35 C2U30_02405 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C2U30_02410 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C2U30_02415 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C2U30_02420 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C2U30_02425 ENOG4105BZU Histidine kinase C2U30_02440 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2U30_02450 ENOG4108KHX Diguanylate cyclase C2U30_02460 ENOG4105ETE Transcriptional regulator (LacI family C2U30_02465 ENOG4108RVA ribokinase C2U30_02470 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C2U30_02475 ENOG4105CNN ABC, transporter C2U30_02480 ENOG4105C2J ABC transporter C2U30_02485 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C2U30_02490 ENOG4108K3A Glutathione S-transferase C2U30_02505 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C2U30_02510 ENOG4105Q9Y Universal stress protein C2U30_02515 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C2U30_02530 ENOG4105C59 p-type ATPase C2U30_02540 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) C2U30_02555 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C2U30_02565 ENOG4108ZGC gaf domain protein C2U30_02570 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) C2U30_02575 ENOG4105CN1 protease C2U30_02580 ENOG4105CD8 aminopeptidase N C2U30_02590 ENOG4105C7I Dehydrogenase C2U30_02595 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C2U30_02600 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) C2U30_02605 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C2U30_02615 ENOG4105C5H ABC transporter C2U30_02625 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) C2U30_02630 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) C2U30_02635 ENOG4105DAN ATP-dependent protease C2U30_02670 ENOG4105MQ5 zona occludens toxin C2U30_02705 ENOG4105X2V dna damage-inducible protein C2U30_02715 ENOG4105H2K paraquat-inducible protein a C2U30_02720 ENOG4105DY2 Paraquat-inducible protein b C2U30_02725 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2U30_02745 ENOG4108KTG Membrane protein, drug metabolite transporter C2U30_02820 ENOG4105VUN Transcriptional regulator C2U30_02895 ENOG4105F2I Transposase C2U30_02915 ENOG4105F8V Hydrolase, tatD family C2U30_02920 ENOG4107QRG dna polymerase iii C2U30_02925 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C2U30_02930 ENOG4105HHA aminodeoxychorismate lyase C2U30_02935 ENOG4105YAZ 4-amino-4-deoxychorismate lyase C2U30_02940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2U30_02945 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C2U30_02950 ENOG4105CHR reductase C2U30_02955 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C2U30_02960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U30_02965 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C2U30_02970 ENOG4105VGS 50s ribosomal protein l32 C2U30_02975 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C2U30_02985 ENOG4108UHJ MAF-like protein C2U30_02990 ENOG4105EI2 Pseudouridine synthase C2U30_02995 ENOG4105C03 ribonuclease C2U30_03000 ENOG4105CJ3 phosphate transporter C2U30_03005 ENOG4105DHP deoxycytidine triphosphate deaminase C2U30_03010 ENOG4105DBI uridine monophosphokinase C2U30_03015 ENOG4105D1F ATP-binding protein C2U30_03020 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C2U30_03030 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 C2U30_03035 ENOG4108N3W hemolysin secretion protein C2U30_03040 ENOG4105DR4 Methyltransferase C2U30_03050 ENOG4105FAT Acyl-transferase C2U30_03055 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) C2U30_03060 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C2U30_03065 ENOG4105C5X domain protein C2U30_03070 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_03080 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C2U30_03090 ENOG4105CQ7 ATP-dependent helicase C2U30_03100 ENOG4105WH1 Two component transcriptional regulator luxr family C2U30_03105 ENOG4105DWD nucleoside recognition domain protein C2U30_03110 ENOG4105EUB pirin domain protein C2U30_03115 ENOG4105CR8 Transcriptional regulator C2U30_03120 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C2U30_03125 ENOG4107QMP dna polymerase iii subunits gamma and tau C2U30_03130 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C2U30_03135 ENOG4105WD1 Membrane C2U30_03140 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) C2U30_03150 ENOG4105DXC membrane C2U30_03165 ENOG4105CEY Amp-dependent synthetase and ligase C2U30_03170 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C2U30_03180 ENOG41072GX Peptidase M22 Glycoprotease C2U30_03185 ENOG4105DVT helicase C2U30_03195 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C2U30_03200 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C2U30_03205 ENOG4105CIH Imidazole acetol-phosphate transaminase C2U30_03215 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C2U30_03220 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C2U30_03225 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_03235 ENOG4105BZU Histidine kinase C2U30_03240 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C2U30_03245 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C2U30_03255 ENOG4105D29 Helix-turn-helix type 11 domain protein C2U30_03260 ENOG4105CEY Amp-dependent synthetase and ligase C2U30_03270 ENOG4107MBR 17 kDa surface antigen C2U30_03285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2U30_03290 ENOG4105EHG Permease protein C2U30_03315 ENOG4108VWS Yaeq family C2U30_03325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U30_03330 ENOG4105CHU acetyl-coa acetyltransferase C2U30_03335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2U30_03375 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation C2U30_03380 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation C2U30_03385 ENOG4105D58 Diguanylate phosphodiesterase C2U30_03390 ENOG4105CHU acetyl-coa acetyltransferase C2U30_03405 ENOG4105NBK UPF0345 protein C2U30_03410 ENOG4105EJQ L-serine dehydratase C2U30_03420 ENOG4105EJQ L-serine dehydratase C2U30_03430 ENOG4105CVE Lytic murein transglycosylase C2U30_03435 ENOG4105VNG YcgL domain-containing protein C2U30_03440 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C2U30_03445 ENOG4107QMS site-determining protein C2U30_03450 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) C2U30_03460 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase C2U30_03470 ENOG4105XW2 UPF0263 protein C2U30_03480 ENOG4105QNR S1 RNA binding domain protein C2U30_03505 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C2U30_03510 ENOG4108SXK Transporter Drug Metabolite Exporter family C2U30_03515 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C2U30_03520 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 C2U30_03535 ENOG4108R6K riboflavin synthase, subunit alpha C2U30_03540 ENOG4105W1I UPF0253 protein C2U30_03545 ENOG4107QI1 Mate efflux family protein C2U30_03575 ENOG4105CQ2 DNA polymerase C2U30_03580 ENOG4105EUB pirin domain protein C2U30_03590 ENOG4105D1S lipid A biosynthesis C2U30_03595 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase C2U30_03605 ENOG4105DUM transcriptional regulator, lysR family C2U30_03615 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C2U30_03630 ENOG4105CBN LysR family transcriptional regulator C2U30_03635 ENOG4105CHR reductase C2U30_03640 ENOG4105CS2 ec 3.2.1.21 C2U30_03645 ENOG4108KB2 LysR family Transcriptional regulator C2U30_03650 ENOG4105BZU Histidine kinase C2U30_03655 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C2U30_03660 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C2U30_03675 ENOG4105DND Transcriptional regulator C2U30_03680 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator C2U30_03685 ENOG4105C2J ABC transporter C2U30_03690 ENOG4107R9N ABC transporter C2U30_03695 ENOG41062B0 ABC transporter, permease C2U30_03745 ENOG4108C33 Resolvase C2U30_03780 ENOG4105HF0 Membrane C2U30_03785 ENOG4105D5Q Arginine ornithine antiporter C2U30_03795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U30_03800 ENOG4105E39 Enoyl-CoA hydratase C2U30_03805 ENOG4105E39 Enoyl-CoA hydratase C2U30_03810 ENOG4105C1G acyl-Coa dehydrogenase C2U30_03815 ENOG4105C26 Dehydrogenase C2U30_03820 ENOG4105C1G acyl-Coa dehydrogenase C2U30_03825 ENOG4107QX3 carboxylase C2U30_03830 ENOG4105E39 Enoyl-CoA hydratase C2U30_03840 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C2U30_03855 ENOG4106HK8 GPR1 FUN34 yaaH family protein C2U30_03860 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) C2U30_03870 ENOG4105BZG amino acid carrier protein C2U30_03875 ENOG41060WC Enoyl-CoA hydratase C2U30_03890 ENOG41062QD Membrane C2U30_03895 ENOG4107QN1 sodium solute C2U30_03900 ENOG4105C5H ABC transporter C2U30_03905 ENOG4105EIN peptidylprolyl cis-trans isomerase C2U30_03910 ENOG4105K70 DNA-binding protein C2U30_03915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2U30_03920 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C2U30_03925 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2U30_03930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C2U30_03950 ENOG4105D60 lipoprotein releasing system transmembrane protein C2U30_03955 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C2U30_03960 ENOG4105D60 lipoprotein releasing system transmembrane protein C2U30_03970 ENOG4108JA2 transcriptioN-repair coupling factor C2U30_03975 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 C2U30_03980 ENOG4107QSI ABC, transporter C2U30_03985 ENOG4108IPJ Membrane C2U30_03995 ENOG4108BY2 phosphohistidine phosphatase C2U30_04000 ENOG4107QXK peptidase C2U30_04005 ENOG4105FQ6 thiopurine methyltransferase C2U30_04015 ENOG41082F9 transcriptional regulator C2U30_04035 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U30_04060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U30_04065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U30_04075 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C2U30_04085 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U30_04090 ENOG4105D4P Coproporphyrinogen iii oxidase C2U30_04095 ENOG41090EK ompa motb domain protein C2U30_04100 ENOG4105BZU Histidine kinase C2U30_04105 ENOG4108WS1 C2U30_04115 ENOG41090A4 Pterin carbinolamine dehydratase C2U30_04120 ENOG4105MIR Phenylalanine 4-monooxygenase C2U30_04125 ENOG4106K28 UPF0283 membrane protein C2U30_04130 ENOG4105CM6 amino acid regulated cytosolic protein C2U30_04140 ENOG4105YYT phage shock protein B C2U30_04145 ENOG41087YS Phage shock protein A C2U30_04150 ENOG4105E51 psp operon transcriptional activator C2U30_04155 ENOG4108J59 Extracellular solute-binding protein, family 5 C2U30_04160 ENOG4108I5W peptide transport system, permease protein C2U30_04165 ENOG4108EU3 peptide transport system, permease C2U30_04170 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein C2U30_04175 ENOG4108JQ2 peptide transport system atp-binding protein C2U30_04180 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase C2U30_04185 ENOG4105DDV Transcriptional regulator (LacI family C2U30_04190 ENOG4105C5Y PTS System C2U30_04195 ENOG4105CS2 ec 3.2.1.21 C2U30_04200 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C2U30_04205 ENOG4105E96 Colicin v production protein C2U30_04210 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C2U30_04215 ENOG4105D1H recombination factor protein RarA C2U30_04220 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C2U30_04225 ENOG4105CNU cell division protein FtsK C2U30_04230 ENOG4105EW9 transcriptional regulator AsnC family C2U30_04235 ENOG4105DCF alanine dehydrogenase C2U30_04240 ENOG4105C3M thioredoxin reductase C2U30_04245 ENOG4105BZU Histidine kinase C2U30_04250 ENOG4107MBR 17 kDa surface antigen C2U30_04255 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C2U30_04260 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate C2U30_04265 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C2U30_04270 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U30_04275 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C2U30_04280 ENOG4105VEQ Cold shock protein C2U30_04285 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U30_04290 ENOG4105KPY Small multidrug resistance protein C2U30_04305 ENOG4105DDY UPF0142 protein ycaO C2U30_04310 ENOG4105TMB Formate nitrite transporter C2U30_04315 ENOG4105C6N Formate acetyltransferase C2U30_04320 ENOG4108KAZ Involved in phosphonate degradation (By similarity) C2U30_04325 ENOG4108JPW Aminotransferase C2U30_04330 ENOG4107STF Involved in phosphonate degradation (By similarity) C2U30_04340 ENOG4105C4Y ABC transporter C2U30_04350 ENOG4107RCV ABC transporter, permease C2U30_04355 ENOG4105CJP fad dependent oxidoreductase C2U30_04365 ENOG4105F2I Transposase C2U30_04380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C2U30_04385 ENOG4105CMV Succinyl-CoA synthetase subunit beta C2U30_04390 ENOG4105C7S Dehydrogenase C2U30_04395 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C2U30_04400 ENOG4105E33 succinate dehydrogenase C2U30_04405 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) C2U30_04410 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein C2U30_04415 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit C2U30_04420 ENOG4105BZN citrate synthase C2U30_04435 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2U30_04440 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C2U30_04450 ENOG4105CEE C4-dicarboxylate transporter C2U30_04465 ENOG4108VKG metal-dependent hydrolase C2U30_04480 ENOG4105NRA 50s ribosomal protein l31 type b C2U30_04495 ENOG4105CNN ABC, transporter C2U30_04505 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator C2U30_04510 ENOG4105EF1 ribulokinase C2U30_04520 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C2U30_04525 ENOG4105ETT transcriptional Regulator, LysR family C2U30_04530 ENOG4105CHM Aminotransferase C2U30_04550 ENOG4105FF5 Membrane C2U30_04555 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2U30_04560 ENOG4105CJB Exodeoxyribonuclease I C2U30_04570 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 C2U30_04575 ENOG4105VAW lrga family C2U30_04580 ENOG41067MG lrgb family C2U30_04585 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) C2U30_04590 ENOG4108IQE Amp-dependent synthetase and ligase C2U30_04595 ENOG4105MH2 YfcL protein C2U30_04605 ENOG4105EE5 Membrane protein terC C2U30_04610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U30_04615 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C2U30_04620 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C2U30_04625 ENOG4105C10 Electron transfer flavoprotein C2U30_04630 ENOG4105BZJ Electron transfer flavoprotein C2U30_04635 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C2U30_04640 ENOG4107QUT magnesium and cobalt transport protein CorA C2U30_04645 ENOG4105QZU Inner membrane protein YfeZ C2U30_04660 ENOG4105D05 Receptor C2U30_04665 ENOG4105DQ5 transport system permease protein C2U30_04670 ENOG4105TVJ transport system, permease C2U30_04675 ENOG4105E0A ABC, transporter C2U30_04680 ENOG4108TSE Transferase C2U30_04685 ENOG4105J76 Periplasmic binding protein C2U30_04690 ENOG4105CEY Amp-dependent synthetase and ligase C2U30_04700 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C2U30_04705 ENOG4105CEY Amp-dependent synthetase and ligase C2U30_04710 ENOG4105WQI isochorismatase C2U30_04715 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C2U30_04725 ENOG4105F3T (LipO)protein C2U30_04740 ENOG4105BZU Histidine kinase C2U30_04755 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_04760 ENOG4107RE1 Inosine-guanosine kinase C2U30_04765 ENOG4105WJG Glutathione C2U30_04770 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2U30_04775 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C2U30_04785 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C2U30_04790 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C2U30_04800 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF C2U30_04805 ENOG4105CQS hydrogenase expression formation protein HypD C2U30_04810 ENOG4105C45 hydrogenase expression formation protein (HypE) C2U30_04815 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) C2U30_04820 ENOG4107RSS Hydrogenase accessory protein HypB C2U30_04825 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) C2U30_04830 ENOG4105C3U ABC transporter C2U30_04835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U30_04840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U30_04860 ENOG4108WGS hydrogenase 2-specific chaperone C2U30_04865 ENOG4108USZ hydrogenase C2U30_04870 ENOG4105DPX Hydrogenase, large subunit C2U30_04875 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit C2U30_04880 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U30_04885 ENOG4105E3S small subunit C2U30_04890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U30_04900 ENOG4108J1Q C2U30_04910 ENOG4105CHH sulfate transporter C2U30_04990 ENOG4105C2C drug resistance transporter, Bcr CflA C2U30_05010 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C2U30_05040 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C2U30_05045 ENOG4107QR9 Iron-sulfur cluster binding protein C2U30_05050 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U30_05055 ENOG4105DAA L-lactate C2U30_05060 ENOG4105CR8 Transcriptional regulator C2U30_05085 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U30_05090 ENOG4107QZM n-acetylglutamate synthase C2U30_05095 ENOG4105CFH Aspartokinase C2U30_05105 ENOG4107T7U Sulfatase C2U30_05110 ENOG4105K8R UPF0145 protein C2U30_05115 ENOG4105CEP NADH dehydrogenase C2U30_05125 ENOG4105DPN Oligoendopeptidase f C2U30_05130 ENOG4105DPN Oligoendopeptidase f C2U30_05135 ENOG4105CKW Inner membrane protein yedI C2U30_05145 ENOG4107SDU Methyl-accepting chemotaxis C2U30_05150 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U30_05155 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U30_05190 ENOG4105K59 histidine triad (HIT) protein C2U30_05195 ENOG4108NVR Methyl-accepting chemotaxis C2U30_05205 ENOG4105CD3 dihydroorotase C2U30_05220 ENOG4107QJT sodium dicarboxylate symporter C2U30_05230 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U30_05235 ENOG4105DU1 integral membrane protein, terc C2U30_05240 ENOG4108JQ7 (ABC) transporter C2U30_05245 ENOG4105C3U ABC transporter C2U30_05250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U30_05255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U30_05260 ENOG4107QSI ABC, transporter C2U30_05265 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C2U30_05270 ENOG4108EKI Dehydrogenase C2U30_05275 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_05280 ENOG4108HRK Histidine kinase C2U30_05285 ENOG4108NEV two component transcriptional regulator, LytTR family C2U30_05295 ENOG4105EGS Mechanosensitive ion channel C2U30_05300 ENOG4105KK7 inner membrane protein YiaW C2U30_05305 ENOG4105EFX secretion protein, HlyD family C2U30_05310 ENOG4105CFI type iii restriction protein res subunit C2U30_05315 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase C2U30_05320 ENOG41090BQ Glutaredoxin C2U30_05330 ENOG4105CHM Aminotransferase C2U30_05335 ENOG4105CSX c4-dicarboxylate anaerobic carrier C2U30_05340 ENOG4105RKW reductase (By C2U30_05350 ENOG4107SDU Methyl-accepting chemotaxis C2U30_05360 ENOG4108PCN EamA-like transporter family C2U30_05365 ENOG4105DGN Electron transport complex C2U30_05370 ENOG4108R3D Electron transport complex C2U30_05380 ENOG4105D6A Electron transport complex C2U30_05385 ENOG4108UQQ Electron transport complex C2U30_05390 ENOG4105DZB Electron transport complex C2U30_05395 ENOG4105CSM endonuclease III C2U30_05400 ENOG4108UYE Lactoylglutathione lyase C2U30_05420 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C2U30_05430 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2U30_05445 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C2U30_05450 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase C2U30_05455 ENOG4105D2T synthase C2U30_05465 ENOG4108S0S Nucleotidyl transferase C2U30_05470 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C2U30_05475 ENOG4105F0R Cytidylyltransferase C2U30_05495 ENOG4105MQ3 flagellar protein FliS C2U30_05505 ENOG41063QE flagellar protein FlaG C2U30_05515 ENOG4105I03 Flagellin C2U30_05535 ENOG4105EN6 Membrane C2U30_05545 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C2U30_05555 ENOG4108JQB penicillin-binding protein 1C C2U30_05560 ENOG4105DN3 alpha-2-macroglobulin domain protein C2U30_05565 ENOG4105IPI Membrane C2U30_05575 ENOG4105J12 Multidrug resistance protein mdtN C2U30_05590 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C2U30_05595 ENOG4105BZU Histidine kinase C2U30_05600 ENOG4105F1A Pyruvate formate-lyase C2U30_05610 ENOG4106YG3 ABC transporter C2U30_05615 ENOG4105DSP amino acid AbC transporter C2U30_05620 ENOG4106PMH Extracellular solute-binding protein family 3 C2U30_05625 ENOG4108JEH abc transporter atp-binding protein C2U30_05630 ENOG4105DWU Membrane C2U30_05635 ENOG4105DYB Isoaspartyl dipeptidase C2U30_05640 ENOG4106PMH Extracellular solute-binding protein family 3 C2U30_05650 ENOG4108ZYK Acyl carrier protein phosphodiesterase C2U30_05665 ENOG4105K89 arsenate reductase C2U30_05675 ENOG4105ERG peptidase m48, ste24p C2U30_05680 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C2U30_05700 ENOG4105CSR polyphosphate kinase 2 C2U30_05710 ENOG4108IJ9 (ABC) transporter C2U30_05715 ENOG4105EG2 ABC transporter, permease C2U30_05720 ENOG4105D56 permease protein C2U30_05725 ENOG4107FKK extracellular solute-binding protein family 1 C2U30_05730 ENOG4106V8H Nucleoid-associated protein C2U30_05735 ENOG4105PAN UPF0352 protein C2U30_05740 ENOG4105E68 Sulfatase C2U30_05745 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C2U30_05750 ENOG4105CUG Oligopeptidase b C2U30_05770 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) C2U30_05775 ENOG4108WFC UPF0438 protein yifE C2U30_05790 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U30_05795 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase C2U30_05800 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C2U30_05810 ENOG4105E98 transcriptional regulator DeoR family C2U30_05815 ENOG4105CXY transporter C2U30_05820 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C2U30_05825 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C2U30_05830 ENOG4105HEI LysR family (Transcriptional regulator C2U30_05855 ENOG4105F27 Major Facilitator C2U30_05865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U30_05870 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U30_05875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U30_05885 ENOG4108Q2J Inner membrane protein YebE C2U30_05895 ENOG4106428 Protein of unknown function (DUF2496) C2U30_05905 ENOG4105C5Q Transcriptional regulator C2U30_05915 ENOG4105DJ2 Major Facilitator Superfamily C2U30_05920 ENOG4105FE9 pseudouridine synthase C2U30_05925 ENOG4105D82 Glutamate dehydrogenase C2U30_05945 ENOG4105CFI type iii restriction protein res subunit C2U30_05955 ENOG4105BZU Histidine kinase C2U30_05970 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) C2U30_05985 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2U30_06000 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C2U30_06010 ENOG4108YYC ycei family C2U30_06015 ENOG4105CC0 LysR family Transcriptional regulator C2U30_06025 ENOG4105CKU formyltetrahydrofolate synthetase C2U30_06030 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_06035 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_06040 ENOG4105EUJ GTP cyclohydrolase i C2U30_06045 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2U30_06050 ENOG4105D06 uba thif-type nad fad binding protein C2U30_06055 ENOG41082A2 Alpha beta hydrolase C2U30_06060 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C2U30_06065 ENOG4105E0C molybdate abc transporter C2U30_06070 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2U30_06075 ENOG4108ZAF Molybdopterin C2U30_06080 ENOG4105M00 molybdopterin converting factor, subunit 1 C2U30_06085 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U30_06090 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U30_06095 ENOG4105CUW cytochrome C-TYPE protein C2U30_06105 ENOG4105GXZ Ferredoxin-type protein NapH C2U30_06110 ENOG4108BGM Quinol dehydrogenase periplasmic component C2U30_06115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C2U30_06125 ENOG4108ZNS ferredoxin-type protein NapF C2U30_06130 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U30_06135 ENOG4105BZU Histidine kinase C2U30_06140 ENOG4105WH1 Two component transcriptional regulator luxr family C2U30_06155 ENOG4105BZU Histidine kinase C2U30_06165 ENOG4105CHW UPF0052 protein C2U30_06175 ENOG4105E7A Glutamine amidotransferase C2U30_06180 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C2U30_06185 ENOG4107QPN acyl-Coa dehydrogenase C2U30_06190 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_06200 ENOG4107RZZ dna polymerase iii epsilon subunit C2U30_06205 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U30_06210 ENOG4105D1A Methyltransferase C2U30_06215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C2U30_06220 ENOG4105E9H Lytic Murein transglycosylase C2U30_06225 ENOG4107NA1 Endonuclease Exonuclease phosphatase C2U30_06235 ENOG4105NAU thioesterase Superfamily protein C2U30_06245 ENOG41060NJ transcriptional regulator C2U30_06250 ENOG4107SC1 transglycosylase C2U30_06255 ENOG4105BZU Histidine kinase C2U30_06260 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA C2U30_06275 ENOG4105MA0 exported protein C2U30_06280 ENOG4105CFU surface antigen C2U30_06290 ENOG4105KQ5 peptidylprolyl cis-trans isomerase C2U30_06300 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U30_06310 ENOG4105VNH ABC transporter solute-binding protein C2U30_06320 ENOG4108VGW abc transporter atp-binding protein C2U30_06325 ENOG4108T9J Cdp-alcohol phosphatidyltransferase C2U30_06330 ENOG4105CVE Lytic murein transglycosylase C2U30_06335 ENOG41090MY MarR family Transcriptional regulator C2U30_06345 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 C2U30_06350 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) C2U30_06355 ENOG4105EV9 Alpha Beta Hydrolase C2U30_06365 ENOG4105NNH LexA regulated protein C2U30_06370 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) C2U30_06380 ENOG41090R7 Ferric uptake C2U30_06385 ENOG4105CX6 glutaminyL-tRNA synthetase C2U30_06390 ENOG4105E2D ec 3.2.1.52 C2U30_06395 ENOG4105CI1 PTS System C2U30_06400 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C2U30_06405 ENOG4105CE4 GlcNAc 6-P deacetylase C2U30_06410 ENOG4105E2R ROK family C2U30_06415 ENOG4105DIJ Phosphoethanolamine transferase C2U30_06425 ENOG4105CDY transcriptional regulatory protein C2U30_06430 ENOG4105C9M aspartyl-trna synthetase C2U30_06440 ENOG41081XQ Conserved Protein C2U30_06445 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) C2U30_06450 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C2U30_06470 ENOG4105C5Q Transcriptional regulator C2U30_06475 ENOG4108QBX (LipO)protein C2U30_06485 ENOG4107RGH Aldehyde dehydrogenase C2U30_06490 ENOG4107Z3H Transcriptional regulator, TetR family C2U30_06505 ENOG4105C6T cysteine synthase C2U30_06525 ENOG4105UQX Mate efflux family protein C2U30_06535 ENOG4105Z2P Protein of unknown function (DUF465) C2U30_06540 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) C2U30_06550 ENOG4105QVC MOSC domain-containing protein C2U30_06550 ENOG4105QVC MOSC domain-containing protein C2U30_06555 ENOG4105D0M Protease HtpX homolog C2U30_06560 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C2U30_06565 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2U30_06570 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C2U30_06575 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C2U30_06595 ENOG4105C5S asparaginyl-tRNA synthetase C2U30_06600 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2U30_06610 ENOG4105CH2 amidohydrolase C2U30_06615 ENOG4105CEE C4-dicarboxylate transporter C2U30_06635 ENOG4107TII Recombinase C2U30_06640 ENOG4105KUZ arsenate reductase C2U30_06645 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C2U30_06660 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C2U30_06670 ENOG410829K Lysine exporter protein (Lyse ygga) C2U30_06675 ENOG4108NVR Methyl-accepting chemotaxis C2U30_06680 ENOG4105RX8 Protein of unknown function (DUF1523) C2U30_06695 ENOG4105DU0 nucleoside hydrolase C2U30_06700 ENOG4105D3G Pseudouridine synthase C2U30_06705 ENOG4108I5U Uridine phosphorylase C2U30_06710 ENOG4105C0A alcohol dehydrogenase C2U30_06715 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U30_06720 ENOG4105K4T epimerase C2U30_06725 ENOG4105VDB UPF0125 protein C2U30_06730 ENOG4108Z1B Cyclase dehydrase C2U30_06735 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C2U30_06805 ENOG4105EFV Major head subunit C2U30_06810 ENOG4108TVE i protein C2U30_06820 ENOG41080IJ Diacylglycerol kinase C2U30_06825 ENOG4105DIJ Phosphoethanolamine transferase C2U30_06845 ENOG4105QIB mu-like prophage Flumu protein gp29 C2U30_06850 ENOG4105CF2 Mu-like prophage FluMu protein GP28 C2U30_06855 ENOG4108Z6H mu-like prophage Flumu protein gp27 C2U30_06995 ENOG4108C33 Resolvase C2U30_07010 ENOG4108J1Q C2U30_07020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U30_07030 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C2U30_07040 ENOG4107QZW Altronate oxidoreductase C2U30_07045 ENOG4105CTX dehydratase C2U30_07050 ENOG4105P66 Membrane C2U30_07055 ENOG4107SS6 2-dehydro-3-deoxygluconokinase C2U30_07060 ENOG4108UHU Aldolase C2U30_07075 ENOG4108YYD acetyltransferase C2U30_07100 ENOG4107R11 Transcriptional regulator C2U30_07105 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C2U30_07125 ENOG4105M2J Glutaredoxin C2U30_07130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U30_07135 ENOG410903C (LipO)protein C2U30_07140 ENOG4108QUE repeat-containing protein C2U30_07145 ENOG4105KWW Biogenesis protein C2U30_07150 ENOG4107QX9 Thiol disulfide interChange protein C2U30_07155 ENOG4105DA4 cytochrome c-type biogenesis protein C2U30_07160 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) C2U30_07165 ENOG4105X3C heme exporter protein C2U30_07170 ENOG41060IM Heme exporter protein C2U30_07175 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) C2U30_07190 ENOG4108V3W Chemotaxis protein, CheW C2U30_07200 ENOG4107QJE Chromosome Partitioning Protein C2U30_07205 ENOG4108SEK ompa motb domain protein C2U30_07210 ENOG4105E14 MotA TolQ exbB proton channel C2U30_07215 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C2U30_07220 ENOG4105CBS Chea signal transduction histidine kinase C2U30_07225 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) C2U30_07230 ENOG4108VYJ response regulator receiver protein C2U30_07235 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U30_07245 ENOG4105FZW flagellar biosynthesis regulator FlhF C2U30_07250 ENOG4105D7B Flagellar biosynthesis protein flha C2U30_07255 ENOG4105D00 flagellar biosynthetic protein flhB C2U30_07260 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C2U30_07265 ENOG4105VS8 Flagellar biosynthetic protein fliq C2U30_07270 ENOG4105CN7 Flagellar biosynthetic protein FliP C2U30_07275 ENOG4105VTB flagellar biosynthesis protein fliO C2U30_07280 ENOG4105DD5 Flagellar motor switch protein C2U30_07285 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U30_07305 ENOG4108JIR Flagellum-specific ATP synthase C2U30_07315 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U30_07320 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C2U30_07325 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C2U30_07335 ENOG4105K89 arsenate reductase C2U30_07340 ENOG4105D6J arsenicaL-resistance protein C2U30_07345 ENOG41085FC arsR family transcriptional regulator C2U30_07350 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_07355 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C2U30_07370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U30_07380 ENOG4108JQ7 (ABC) transporter C2U30_07390 ENOG4105RD7 BadF BadG BcrA BcrD C2U30_07395 ENOG4105E2D ec 3.2.1.52 C2U30_07400 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U30_07410 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U30_07415 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) C2U30_07420 ENOG4105ERU peptidase C2U30_07425 ENOG4105UBK short-chain dehydrogenase reductase C2U30_07430 ENOG4105C5Q Transcriptional regulator C2U30_07440 ENOG4105C87 Aminotransferase class I and II C2U30_07455 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C2U30_07470 ENOG4107WCA isomerase C2U30_07475 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2U30_07480 ENOG4105DR5 peptidase C2U30_07485 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C2U30_07510 ENOG4105KME endoribonuclease L-psp C2U30_07515 ENOG4108J1Q C2U30_07525 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2U30_07530 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C2U30_07535 ENOG4105GPY SprT protein C2U30_07545 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C2U30_07550 ENOG4105D7Z glutathione synthase C2U30_07555 ENOG4108UJU UPF0301 protein C2U30_07560 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C2U30_07575 ENOG41066YJ Beta-lactamase C2U30_07580 ENOG4105BZG amino acid carrier protein C2U30_07585 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2U30_07600 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C2U30_07605 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) C2U30_07610 ENOG4105CK2 sodium dicarboxylate symporter C2U30_07620 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2U30_07625 ENOG41063JG Transcriptional regulator C2U30_07635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C2U30_07640 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C2U30_07645 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C2U30_07650 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C2U30_07655 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C2U30_07665 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2U30_07670 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C2U30_07675 ENOG4105C3G gtp-binding protein C2U30_07680 ENOG4105DFP Integrase C2U30_07730 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2U30_07745 ENOG4105DZR Type I site-specific deoxyribonuclease C2U30_07750 ENOG4105ESI atpase involved in dna repair C2U30_07755 ENOG4105CB5 ATP-dependent DNA helicase recG C2U30_07760 ENOG41082EK Restriction modification system DNA (Specificity C2U30_07815 ENOG4107QWE )-transporter C2U30_07820 ENOG41060QA UPF0267 protein C2U30_07840 ENOG4107VXZ Hydrolase C2U30_07855 ENOG4105C26 Dehydrogenase C2U30_07860 ENOG4105F4X arginine C2U30_07865 ENOG4105C8Y Acetylornithine aminotransferase C2U30_07880 ENOG4105C31 Tryptophanyl-tRNA synthetase C2U30_07885 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U30_07890 ENOG4105DJV ribulose-phosphate 3-epimerase C2U30_07895 ENOG4105DFE Dna adenine methylase C2U30_07905 ENOG4105D49 3-dehydroquinate synthase C2U30_07910 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C2U30_07915 ENOG4105E4G Type IV pilus C2U30_07940 ENOG4108JQC penicillin-binding protein 1A C2U30_07945 ENOG4105C5Q Transcriptional regulator C2U30_07960 ENOG4105EJC lysr family transcriptional regulator C2U30_07975 ENOG4105DR5 peptidase C2U30_07985 ENOG4105EGS Mechanosensitive ion channel C2U30_07990 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2U30_07995 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_08005 ENOG4105E33 succinate dehydrogenase C2U30_08010 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) C2U30_08015 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) C2U30_08030 ENOG4105T0Z Conserved Protein C2U30_08035 ENOG4106371 Methyltransferase C2U30_08055 ENOG4108IXY short-chain dehydrogenase reductase C2U30_08065 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U30_08070 ENOG4105DHQ Histidine kinase C2U30_08075 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C2U30_08080 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U30_08090 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C2U30_08095 ENOG4108UMI ABC transporter, permease C2U30_08100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U30_08105 ENOG4105D01 (LipO)protein C2U30_08120 ENOG4105C5I Dehydrogenase C2U30_08130 ENOG4108KHX Diguanylate cyclase C2U30_08140 ENOG4105BZU Histidine kinase C2U30_08145 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 C2U30_08160 ENOG4105VEQ Cold shock protein C2U30_08165 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) C2U30_08170 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C2U30_08175 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2U30_08180 ENOG4105C9A Phoh family C2U30_08185 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C2U30_08190 ENOG4108JU5 Magnesium and cobalt efflux protein C2U30_08195 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C2U30_08200 ENOG4107PAI alpha helical protein C2U30_08205 ENOG4105C8T Leucyl-tRNA synthetase C2U30_08230 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C2U30_08235 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) C2U30_08240 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C2U30_08245 ENOG4105CJN penicillin-binding protein C2U30_08250 ENOG4105CNI cell division protein FtsW C2U30_08255 ENOG4105CVE Lytic murein transglycosylase C2U30_08260 ENOG4105K6T rare lipoprotein A C2U30_08265 ENOG4105DZ1 carboxypeptidase C2U30_08270 ENOG4108Z43 UPF0250 protein C2U30_08275 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C2U30_08285 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C2U30_08300 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_08315 ENOG4107SWG transcriptional regulator MERR family C2U30_08320 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C2U30_08330 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C2U30_08335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U30_08340 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) C2U30_08360 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U30_08365 ENOG4105CFP Peptidase U32 C2U30_08370 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C2U30_08385 ENOG4105WAY exported protein C2U30_08390 ENOG41090EX DsrE family C2U30_08395 ENOG4105E5W Transporter C2U30_08400 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C2U30_08405 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C2U30_08410 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C2U30_08415 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C2U30_08420 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C2U30_08425 ENOG4105CHV Transcription elongation factor NusA C2U30_08430 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C2U30_08450 ENOG4105CP7 Triose-phosphate isomerase C2U30_08455 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C2U30_08460 ENOG4105EEI dihydropteroate synthase C2U30_08465 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U30_08470 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) C2U30_08475 ENOG4105HBR Rna-binding protein C2U30_08485 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C2U30_08490 ENOG4107XSU flagellar motor protein motb C2U30_08495 ENOG4105E14 MotA TolQ exbB proton channel C2U30_08500 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U30_08505 ENOG4105CTB Polyprenyl synthetase C2U30_08510 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C2U30_08515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U30_08520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U30_08530 ENOG4108JQ6 ABC transporter C2U30_08535 ENOG4108ZAI phosphatidylglycerophosphatase a C2U30_08540 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C2U30_08545 ENOG4107YIM Involved in the transcription termination process (By similarity) C2U30_08550 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C2U30_08565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2U30_08570 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C2U30_08580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2U30_08595 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) C2U30_08605 ENOG4105BZU Histidine kinase C2U30_08610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U30_08615 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C2U30_08620 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C2U30_08625 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2U30_08630 ENOG4105RG0 Membrane C2U30_08635 ENOG4108IA2 Sodium pantothenate symporter C2U30_08640 ENOG4105CI1 PTS System C2U30_08645 ENOG4105HEI LysR family (Transcriptional regulator C2U30_08650 ENOG4105CIS alcohol dehydrogenase C2U30_08655 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C2U30_08660 ENOG4108UW5 maltose o-acetyltransferase C2U30_08665 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_08675 ENOG41069NU Nitroreductase C2U30_08680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U30_08685 ENOG4105D07 Signal peptide peptidase, SppA C2U30_08705 ENOG4105VUT cytoplasmic protein C2U30_08710 ENOG4105HDK L-asparaginase C2U30_08715 ENOG4105D6U Sodium Glutamate Symporter C2U30_08720 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_08730 ENOG4105CRK lysyL-tRNA synthetase C2U30_08740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C2U30_08745 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C2U30_08750 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C2U30_08755 ENOG4105GIJ Glycine betaine C2U30_08760 ENOG4108HQS Glycine betaine C2U30_08765 ENOG4108IJ7 Glycine betaine C2U30_08775 ENOG4107XM3 UPF0442 protein C2U30_08780 ENOG4105DWK Membrane C2U30_08790 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U30_08815 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) C2U30_08820 ENOG4105DD7 kinase (PfkB family C2U30_08825 ENOG4107QZF nitrite reductase NADPH large subunit C2U30_08830 ENOG4107QZF nitrite reductase NADPH large subunit C2U30_08835 ENOG4105D7T ABC transporter C2U30_08840 ENOG4105DG7 nitrate ABC transporter C2U30_08855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U30_08885 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C2U30_08895 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) C2U30_08900 ENOG4105V1F Fermentation respiration switch protein C2U30_08905 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) C2U30_08915 ENOG4105CIN aminoacyl-histidine dipeptidase C2U30_08925 ENOG4108JQ7 (ABC) transporter C2U30_08940 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C2U30_08945 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C2U30_08970 ENOG4109015 Biopolymer transport protein exbD tolR C2U30_09030 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U30_09035 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U30_09040 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U30_09045 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U30_09050 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_09060 ENOG4105VEQ Cold shock protein C2U30_09105 ENOG4107QJE Chromosome Partitioning Protein C2U30_09140 ENOG4107YH6 single-stranded DNA-binding protein C2U30_09145 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U30_09160 ENOG4105W1Y Transcriptional regulator C2U30_09170 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C2U30_09330 ENOG4105VT3 DNA binding domain protein, excisionase family C2U30_09385 ENOG4105W5Q DNA repair protein (RadC C2U30_09465 ENOG4105CSR polyphosphate kinase 2 C2U30_09470 ENOG4105C59 p-type ATPase C2U30_09485 ENOG4105HA9 of methanol dehydrogenase type C2U30_09495 ENOG4105CY0 Metallo-Beta-Lactamase C2U30_09500 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C2U30_09505 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2U30_09520 ENOG4105C5I Dehydrogenase C2U30_09525 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C2U30_09540 ENOG4108IXY short-chain dehydrogenase reductase C2U30_09550 ENOG4107QRI Phosphoketolase C2U30_09555 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2U30_09560 ENOG4105W1Y Transcriptional regulator C2U30_09565 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2U30_09585 ENOG4105GR3 Histidine kinase C2U30_09590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U30_09595 ENOG4105E3B Multicopper oxidase C2U30_09630 ENOG4106NZI LysR family Transcriptional regulator C2U30_09670 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C2U30_09675 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C2U30_09680 ENOG4105DJ4 phosphatidylserine decarboxylase C2U30_09685 ENOG4105VYA Uncharacterized conserved protein (DUF2132) C2U30_09705 ENOG4105BZU Histidine kinase C2U30_09715 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) C2U30_09740 ENOG4105BZ1 (ABC) transporter C2U30_09745 ENOG4105SUV lipoprotein YgdR C2U30_09750 ENOG4107RM6 sulfurtransferase C2U30_09755 ENOG4105CSV Glutaminase C2U30_09760 ENOG41090ED Protein with unknown function (DUF469) C2U30_09765 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C2U30_09770 ENOG4105IIU Aminopeptidase C2U30_09775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U30_09780 ENOG4107XTP (EAL) domain protein C2U30_09785 ENOG4105ECP epimerase C2U30_09790 ENOG4105CV6 ABC transporter, permease C2U30_09795 ENOG4108I0Y (ABC) transporter C2U30_09800 ENOG4108UJV acyl-CoA thioesterase i C2U30_09805 ENOG4107R88 Chemotaxis protein (CheV) C2U30_09815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U30_09820 ENOG4105C5H ABC transporter C2U30_09830 ENOG4105D6S protein involved in catabolism of external DNA C2U30_09835 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C2U30_09910 ENOG4105CK7 Sodium proline symporter C2U30_09915 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U30_09920 ENOG4105CUY Mechanosensitive ion channel C2U30_09930 ENOG4105XEP YhcH YjgK YiaL family protein C2U30_09940 ENOG4105D9U N-acetyltransferase C2U30_09950 ENOG4105D4Y metalloprotease C2U30_09960 ENOG4105EV4 Multidrug resistance protein mdtH C2U30_09970 ENOG4105D0C transport protein C2U30_09975 ENOG4108UT2 hemolysin iii C2U30_09980 ENOG4105DY8 decarboxylase C2U30_09985 ENOG4107835 probably involved in intracellular septation (By similarity) C2U30_09990 ENOG4105K9H YciI-like protein C2U30_09995 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C2U30_10000 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein C2U30_10005 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2U30_10010 ENOG4105DUX Transporter C2U30_10015 ENOG4105I93 response regulator C2U30_10045 ENOG4107V40 secretion protein, HlyD family C2U30_10055 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U30_10060 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) C2U30_10065 ENOG410829K Lysine exporter protein (Lyse ygga) C2U30_10090 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2U30_10100 ENOG4105CMQ Chloride channel C2U30_10105 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2U30_10120 ENOG41076MN Phosphoesterase, PA-phosphatase related C2U30_10130 ENOG4105EGI Transcriptional regulator C2U30_10135 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) C2U30_10140 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) C2U30_10145 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C2U30_10150 ENOG4105BZ4 penicillin-binding protein C2U30_10155 ENOG4105CQ7 ATP-dependent helicase C2U30_10165 ENOG4105PW4 Sugar fermentation stimulation protein homolog C2U30_10170 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C2U30_10175 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C2U30_10180 ENOG4105DJ0 Poly(A) Polymerase C2U30_10185 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2U30_10190 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C2U30_10195 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C2U30_10205 ENOG4105E3A (ABC) transporter C2U30_10210 ENOG4105DA5 (ABC) transporter C2U30_10215 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2U30_10220 ENOG410630P Transcriptional regulator C2U30_10225 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C2U30_10230 ENOG4105DFU Cell wall formation (By similarity) C2U30_10235 ENOG4105F0N pyrophosphate phospho-hydrolase C2U30_10250 ENOG4108UUE Transcriptional regulator C2U30_10265 ENOG4105C19 ABC transporter C2U30_10290 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U30_10320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C2U30_10330 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C2U30_10335 ENOG4105C11 sulfate adenylyltransferase), subunit 2 C2U30_10340 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U30_10345 ENOG4107QX8 SPFH domain, Band 7 family protein C2U30_10350 ENOG4105G5H Membrane C2U30_10360 ENOG4105D9R oxidoreductase C2U30_10370 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C2U30_10375 ENOG4105CSA Coproporphyrinogen iii oxidase C2U30_10395 ENOG4105DC1 bifunctional purine biosynthesis protein purh C2U30_10400 ENOG4105C12 Phosphoribosylglycinamide synthetase C2U30_10430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U30_10435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C2U30_10440 ENOG4105KTH gatB Yqey C2U30_10445 ENOG4105VCC 30S ribosomal protein S21 C2U30_10450 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U30_10460 ENOG4108K5P (LipO)protein C2U30_10465 ENOG4108UM1 dedA family C2U30_10470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C2U30_10475 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C2U30_10480 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) C2U30_10485 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C2U30_10490 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C2U30_10495 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C2U30_10500 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C2U30_10505 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C2U30_10510 ENOG4105DXN mazG family C2U30_10515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U30_10520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2U30_10525 ENOG4105BZU Histidine kinase C2U30_10530 ENOG4108W15 Protein of unknown function (DUF1456) C2U30_10535 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase C2U30_10540 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C2U30_10545 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C2U30_10555 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C2U30_10560 ENOG4105C3F Signal peptidase i C2U30_10565 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C2U30_10580 ENOG41069PW sigma-e factor negative regulatory protein C2U30_10585 ENOG4105EMN RNA polymerase sigma factor C2U30_10590 ENOG4108IYU L-aspartate oxidase C2U30_10600 ENOG4105Y75 tpr repeat protein C2U30_10605 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) C2U30_10610 ENOG4105DUM transcriptional regulator, lysR family C2U30_10635 ENOG4105VF7 tolerance protein C2U30_10640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C2U30_10650 ENOG4105CJP fad dependent oxidoreductase C2U30_10655 ENOG4105D2N Aldolase C2U30_10660 ENOG4105BZA Phosphoglycerate kinase C2U30_10665 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C2U30_10670 ENOG4105DKQ ROK family C2U30_10675 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C2U30_10680 ENOG4105E09 nadh pyrophosphatase C2U30_10685 ENOG4106MWK domain protein C2U30_10690 ENOG4105EYW Ion transport protein C2U30_10695 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_10705 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C2U30_10710 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2U30_10730 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C2U30_10735 ENOG4105E5Q amino acid AbC transporter C2U30_10740 ENOG4105E5Q amino acid AbC transporter C2U30_10745 ENOG4105CDA abc transporter atp-binding protein C2U30_10750 ENOG4105CT1 (ABC) transporter C2U30_10755 ENOG4107PU6 Membrane C2U30_10760 ENOG4108UW5 maltose o-acetyltransferase C2U30_10790 ENOG41090U3 tautomerase C2U30_10800 ENOG4107NQ8 LysR family Transcriptional regulator C2U30_10805 ENOG4105CH7 arginosuccinase C2U30_10810 ENOG4105CDH Citrulline--aspartate ligase C2U30_10820 ENOG4105CAS nag kinase C2U30_10825 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C2U30_10835 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C2U30_10840 ENOG4105BZU Histidine kinase C2U30_10845 ENOG4108Z66 YbaK ebsC protein C2U30_10880 ENOG4105CMU LysR family (Transcriptional regulator C2U30_10890 ENOG41067MG lrgb family C2U30_10895 ENOG4105CFH Aspartokinase C2U30_10900 ENOG4105C28 cystathionine C2U30_10905 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) C2U30_10915 ENOG4108Z7R Chaperone CsaA C2U30_10920 ENOG4105C44 Serine transporter C2U30_10925 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C2U30_10930 ENOG4107RK2 ADP-ribose diphosphatase NudE C2U30_10935 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 C2U30_10940 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U30_10945 ENOG4105JQN Transcriptional regulator C2U30_10950 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2U30_10955 ENOG4108UDW Transcriptional regulator, luxr family C2U30_11000 ENOG4108VAU general secretion pathway protein G C2U30_11005 ENOG4105D7Q type ii secretion system C2U30_11010 ENOG4107QHF type ii secretion system protein e C2U30_11015 ENOG4105GVR general secretion pathway protein D C2U30_11025 ENOG4105VEJ Heat shock protein C2U30_11030 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C2U30_11035 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C2U30_11050 ENOG4108R6G acetyltransferase C2U30_11055 ENOG4108XTF Outer Membrane Lipoprotein C2U30_11060 ENOG4105I7R Adenylate cyclase C2U30_11065 ENOG4107IX6 phosphate transport regulator C2U30_11070 ENOG4105CJ3 phosphate transporter C2U30_11075 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C2U30_11090 ENOG4105CEN a g-specific adenine glycosylase C2U30_11095 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) C2U30_11115 ENOG4105UYK outer membrane protein a C2U30_11120 ENOG4108Q2G (LipO)protein C2U30_11125 ENOG4105DY2 Paraquat-inducible protein b C2U30_11130 ENOG4105F1S paraquat-inducible protein a C2U30_11135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2U30_11140 ENOG4107VXZ Hydrolase C2U30_11150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U30_11155 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C2U30_11160 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2U30_11165 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C2U30_11205 ENOG4105DFD Na H antiporter C2U30_11210 ENOG4108M0I Transcriptional regulator C2U30_11215 ENOG4107TYH extracellular solute-binding protein family 1 C2U30_11220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U30_11225 ENOG4105D81 ABC transporter, permease C2U30_11230 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component C2U30_11240 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2U30_11265 ENOG4107QS1 Cytochrome C Oxidase, Subunit III C2U30_11270 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) C2U30_11280 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) C2U30_11285 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) C2U30_11300 ENOG4108UQY Iron-storage protein C2U30_11305 ENOG4108Z5K methylglyoxal synthase C2U30_11320 ENOG4105HDK L-asparaginase C2U30_11335 ENOG4105D4X repressor C2U30_11340 ENOG4105C5Y PTS System C2U30_11345 ENOG4105CG3 alpha amylase, catalytic region C2U30_11350 ENOG4108UW5 maltose o-acetyltransferase C2U30_11360 ENOG4107AQZ Membrane C2U30_11385 ENOG4105R2J Conserved Protein C2U30_11395 ENOG4105DR5 peptidase C2U30_11415 ENOG4105NXV High-affinity zinc uptake system protein C2U30_11420 ENOG4105FDK ABC transporter C2U30_11425 ENOG4105FAV ABC, transporter C2U30_11430 ENOG4105ETT transcriptional Regulator, LysR family C2U30_11440 ENOG4108RG0 uracil-dna glycosylase C2U30_11445 ENOG4105FR1 rard protein C2U30_11450 ENOG41082IR Excinuclease ABC C subunit domain protein C2U30_11465 ENOG41087YS Phage shock protein A C2U30_11470 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase C2U30_11490 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U30_11500 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2U30_11550 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U30_11555 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U30_11565 ENOG4105Y49 secretion protein, HlyD family C2U30_11585 ENOG4105IPS esterase C2U30_11590 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C2U30_11595 ENOG4108SX3 cytoplasmic protein C2U30_11600 ENOG41087AY ADP-Ribose pyrophosphatase C2U30_11605 ENOG4105DFG type I secretion outer membrane protein C2U30_11610 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C2U30_11615 ENOG4105D1S lipid A biosynthesis C2U30_11625 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic C2U30_11630 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C2U30_11635 ENOG4105VJY transcriptional regulator C2U30_11640 ENOG4105NNS Autoinducer synthesis protein C2U30_11645 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C2U30_11650 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) C2U30_11655 ENOG4105CTS PTS system mannitol-specific C2U30_11660 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C2U30_11665 ENOG4105E61 Mannitol repressor protein C2U30_11670 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C2U30_11690 ENOG4108UPT UPF0178 protein C2U30_11705 ENOG4105D9N nucleoside C2U30_11710 ENOG4105C1J atp-dependent rna helicase C2U30_11730 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C2U30_11735 ENOG4105E4F Isochorismate synthase C2U30_11740 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C2U30_11745 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C2U30_11750 ENOG4108IPT Naphthoate synthase C2U30_11755 ENOG4105DNI Converts SHCHC to OSB (By similarity) C2U30_11760 ENOG4105CEY Amp-dependent synthetase and ligase C2U30_11765 ENOG4107MM9 BNR Asp-box repeat-containing protein C2U30_11770 ENOG4108UB4 uncharacterized protein ygjQ C2U30_11775 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U30_11785 ENOG4107IFA Lipase (EC 3.1.1.3) C2U30_11815 ENOG4108IQK o-acetylhomoserine C2U30_11825 ENOG4108I6A alcohol dehydrogenase C2U30_11840 ENOG4105EMU Dehydrogenase C2U30_11860 ENOG4105KT7 mgtC SapB transporter C2U30_11875 ENOG4105E0M Sulfatase C2U30_11880 ENOG4108YXU transcriptional regulator AsnC family C2U30_11890 ENOG4105CVG Homoserine O-transsuccinylase C2U30_11900 ENOG4108I62 cina-like protein C2U30_11905 ENOG4107K5X Membrane-bound metal-dependent hydrolase C2U30_11915 ENOG410667J hydrolase C2U30_11920 ENOG4108Z86 Glutamine amidotransferase C2U30_11930 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant C2U30_11935 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U30_11945 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C2U30_11950 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C2U30_11960 ENOG4105XQ6 frataxin-like protein C2U30_11965 ENOG4106CJB Phospholipase Carboxylesterase C2U30_11970 ENOG4107T0K Adenylate cyclase C2U30_11975 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C2U30_11980 ENOG41076E6 Uroporphyrinogen-III Synthase C2U30_11985 ENOG4105ECF c-methyltransferase C2U30_11990 ENOG410601J HemY protein C2U30_11995 ENOG4105CMS peptidase U62, modulator of DNA gyrase C2U30_12000 ENOG4105N42 UPF0307 protein C2U30_12010 ENOG41090HJ UPF0265 protein C2U30_12040 ENOG4108JCI Transcriptional regulator C2U30_12045 ENOG4105DKK Benzoate C2U30_12055 ENOG4105SYT Methylenetetrahydrofolate reductase C2U30_12075 ENOG4105EIF outer membrane protein W C2U30_12080 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2U30_12085 ENOG41086KC Transcriptional regulator C2U30_12090 ENOG4108UUM single-stranded DNA-binding protein C2U30_12110 ENOG4105VEQ Cold shock protein C2U30_12115 ENOG4105E0F Histidine kinase C2U30_12120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U30_12130 ENOG4108NVR Methyl-accepting chemotaxis C2U30_12140 ENOG4105BZU Histidine kinase C2U30_12145 ENOG4108YZA Nitrogen regulatory protein pii C2U30_12160 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C2U30_12170 ENOG4107QYX exodeoxyribonuclease v alpha C2U30_12175 ENOG4107QKA exodeoxyribonuclease V beta C2U30_12180 ENOG4105DSY exodeoxyribonuclease V, gamma C2U30_12185 ENOG4108VBZ doxx family C2U30_12190 ENOG4105C2I pirin domain protein C2U30_12200 ENOG4105CWB LysR family transcriptional Regulator C2U30_12225 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component C2U30_12235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U30_12245 ENOG4105BZU Histidine kinase C2U30_12265 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2U30_12270 ENOG4105CH6 catalase C2U30_12305 ENOG4105DWY Agmatine deiminase C2U30_12310 ENOG4105ETT transcriptional Regulator, LysR family C2U30_12325 ENOG4108UTZ Dihydroxyacetone kinase C2U30_12330 ENOG4105CMT Dihydroxyacetone kinase C2U30_12405 ENOG4106NZI LysR family Transcriptional regulator C2U30_12430 ENOG4105KPY Small multidrug resistance protein C2U30_12470 ENOG4107QJE Chromosome Partitioning Protein C2U30_12535 ENOG4105FA0 parb-like partition protein C2U30_12555 ENOG4108YGG dna repair protein C2U30_12560 ENOG4105DFS Conserved Protein C2U30_12570 ENOG4105C7N Xanthine uracil vitamin C permease C2U30_12575 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C2U30_12615 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C2U30_12620 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U30_12625 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C2U30_12630 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C2U30_12635 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C2U30_12640 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) C2U30_12650 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) C2U30_12655 ENOG4105KME endoribonuclease L-psp C2U30_12660 ENOG4105WWK YheO domain protein C2U30_12670 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U30_12675 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U30_12680 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C2U30_12685 ENOG4108VZM 50s ribosomal protein L10 C2U30_12690 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C2U30_12695 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C2U30_12700 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C2U30_12705 ENOG4105PM1 preprotein translocase subunit SecE C2U30_12715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U30_12730 ENOG4105CS9 pantothenic acid kinase C2U30_12735 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C2U30_12740 ENOG4105D4A Cell wall formation (By similarity) C2U30_12745 ENOG4107ZYR domain protein C2U30_12755 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U30_12760 ENOG4105CUW cytochrome C-TYPE protein C2U30_12765 ENOG4107QY8 reductase C2U30_12775 ENOG4105IFJ Histidine kinase C2U30_12780 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U30_12795 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) C2U30_12800 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C2U30_12810 ENOG4108UQ5 membrane protein YcdZ C2U30_12815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U30_12825 ENOG4107WP9 Histidine kinase C2U30_12840 ENOG410642E Short chain dehydrogenase C2U30_12845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U30_12855 ENOG4108VVK transcriptional Regulator, AsnC C2U30_12860 ENOG4105CU9 asparagine synthetase A C2U30_12865 ENOG4107T8T UPF0173 metal-dependent hydrolase C2U30_12870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U30_12875 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C2U30_12880 ENOG4105C34 Pseudouridine synthase C2U30_12885 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C2U30_12890 ENOG4105CEM UPF0597 protein C2U30_12895 ENOG4105WWK YheO domain protein C2U30_12900 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U30_12905 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U30_12910 ENOG4108I6A alcohol dehydrogenase C2U30_12915 ENOG4105CF7 AraC family transcriptional regulator C2U30_12920 ENOG4105QNF Outer membrane lipoprotein C2U30_12930 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_12940 ENOG4105DUM transcriptional regulator, lysR family C2U30_12960 ENOG4105CXT aspartate transcarbamylase C2U30_12965 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) C2U30_12970 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) C2U30_12975 ENOG4105CSX c4-dicarboxylate anaerobic carrier C2U30_12980 ENOG4105DBV ornithine carbamoyltransferase C2U30_12985 ENOG4105C5B carbamate kinase C2U30_13000 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_13005 ENOG4107SDZ Galactoside transport system permease protein mglC C2U30_13020 ENOG4105CNT hydrolase family 2 C2U30_13025 ENOG41060NJ transcriptional regulator C2U30_13030 ENOG4105CMR udp-glucose 4-epimerase C2U30_13035 ENOG4105F0Z galactose-1-phosphate uridylyltransferase C2U30_13040 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C2U30_13045 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C2U30_13050 ENOG4105CPC Aldo Keto reductase C2U30_13055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2U30_13060 ENOG4108NIX Factor ChrR C2U30_13065 ENOG4105K6V RNA polymerase C2U30_13075 ENOG4105C75 arginyL-tRNA synthetase C2U30_13085 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C2U30_13090 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C2U30_13110 ENOG4105D0S secretion protein (HlyD C2U30_13115 ENOG4105CJ1 ABC, transporter C2U30_13120 ENOG4107QWP ABC-2 type transporter C2U30_13125 ENOG4107QWP ABC-2 type transporter C2U30_13130 ENOG4107QZF nitrite reductase NADPH large subunit C2U30_13135 ENOG4105WZK nitrite reductase NADPH small subunit C2U30_13140 ENOG4107V9H nitrite transporter C2U30_13145 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U30_13150 ENOG4105CJW magnesium transporter C2U30_13155 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C2U30_13160 ENOG4105EX9 Membrane C2U30_13170 ENOG4105CNG UPF0061 protein C2U30_13175 ENOG4105N7H Cytochrome C2U30_13180 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U30_13185 ENOG4108VUY thioesterase Superfamily protein C2U30_13200 ENOG4108RPX mosc domain containing protein C2U30_13205 ENOG4105D38 putrescine abc transporter C2U30_13210 ENOG4105F38 ABC transporter, permease C2U30_13215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U30_13220 ENOG4108HM4 ABC transporter C2U30_13230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2U30_13235 ENOG4105CFQ glutamine synthetase C2U30_13240 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C2U30_13255 ENOG4108RH0 Crea protein C2U30_13260 ENOG4105C5I Dehydrogenase C2U30_13265 ENOG4105R8A Heat shock protein C2U30_13280 ENOG4107R28 alpha amylase, catalytic region C2U30_13295 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) C2U30_13305 ENOG4105JJR Histidine kinase C2U30_13315 ENOG4105C6K Malic enzyme C2U30_13320 ENOG4105CGD Nad-dependent epimerase dehydratase C2U30_13325 ENOG4105VFB Binds the 23S rRNA (By similarity) C2U30_13330 ENOG4105C25 Primosomal protein n' C2U30_13335 ENOG4105XEA Tetr family transcriptional regulator C2U30_13345 ENOG4105UYK outer membrane protein a C2U30_13350 ENOG4105C7B Threonine dehydratase C2U30_13355 ENOG4105C01 Dihydroxy-acid dehydratase C2U30_13360 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2U30_13365 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit C2U30_13380 ENOG4105C0P Mg chelatase subunit ChlI C2U30_13385 ENOG4106HNH Acyl-transferase C2U30_13390 ENOG4106HNH Acyl-transferase C2U30_13395 ENOG4105EWC Purine nucleoside phosphorylase C2U30_13405 ENOG4108RWI nicotinamidase C2U30_13410 ENOG4107RH7 Nicotinate phosphoribosyltransferase C2U30_13415 ENOG4108Z33 Thiol disulfide Interchange Protein C2U30_13420 ENOG4105E27 serine threonine protein kinase C2U30_13430 ENOG4105PC1 Conserved Protein C2U30_13450 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C2U30_13455 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C2U30_13460 ENOG4105DSJ YicC domain protein C2U30_13470 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C2U30_13475 ENOG4105XA0 heptosyltransferase ii C2U30_13480 ENOG4106WTF Glycosyl transferase, family 2 C2U30_13485 ENOG4105M5K heptosyltransferase C2U30_13490 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C2U30_13495 ENOG4108MJ5 VirK protein C2U30_13500 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C2U30_13510 ENOG4105W0E 50S ribosomal protein L33 C2U30_13515 ENOG4105KDC 50s ribosomal protein l28 C2U30_13520 ENOG4105W5Q DNA repair protein (RadC C2U30_13525 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C2U30_13530 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C2U30_13535 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C2U30_13555 ENOG4105D64 Mechanosensitive ion channel C2U30_13565 ENOG4107QP8 phosphohexose isomerase C2U30_13570 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2U30_13575 ENOG4105EMY transcriptional regulator C2U30_13585 ENOG4105CD5 CoA-binding domain protein C2U30_13620 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C2U30_13625 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C2U30_13630 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C2U30_13635 ENOG4105FCD Major Facilitator C2U30_13640 ENOG4105DY9 regulatoR C2U30_13645 ENOG4108HRK Histidine kinase C2U30_13655 ENOG4105BZU Histidine kinase C2U30_13660 ENOG4107ZHV Transcriptional regulator C2U30_13665 ENOG4108GWT fimbrillin MatB C2U30_13670 ENOG4108NN8 Fimbrial protein C2U30_13675 ENOG4108N3D putative enzyme C2U30_13690 ENOG4108NIW Leucine export protein LeuE C2U30_13695 ENOG4105EU0 Major facilitator Superfamily C2U30_13700 ENOG4105CBX hi0933 family C2U30_13705 ENOG41090A1 ferritin C2U30_13710 ENOG4105BZU Histidine kinase C2U30_13715 ENOG4105RKW reductase (By C2U30_13725 ENOG4108M6U Universal stress protein A C2U30_13755 ENOG4105EMK carboxylate amino acid amine transporter C2U30_13765 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) C2U30_13770 ENOG4105DKP glycosyl transferase, family 9 C2U30_13785 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C2U30_13790 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U30_13795 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase C2U30_13805 ENOG4108EUD Lysophospholipase C2U30_13810 ENOG4105DQF Hydrolase C2U30_13840 ENOG4105Y7M Transcriptional regulator, TetR family C2U30_13845 ENOG410624X efflux transporter, rnd family, mfp subunit C2U30_13850 ENOG4105BZS acriflavin resistance protein C2U30_13855 ENOG4105BZU Histidine kinase C2U30_13860 ENOG4105DC8 reductase C2U30_13870 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C2U30_13875 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C2U30_13885 ENOG4105C08 Histidine kinase C2U30_13890 ENOG4105EEX Two component transcriptional regulator (Winged helix family C2U30_13895 ENOG4105C2C drug resistance transporter, Bcr CflA C2U30_13910 ENOG4105JKW Valine--pyruvate aminotransferase C2U30_13915 ENOG4108ZNX Heat shock protein C2U30_13920 ENOG4108ZNX Heat shock protein C2U30_13925 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein C2U30_13930 ENOG4108R6W Transcriptional regulator, ARAC family C2U30_13935 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U30_13940 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2U30_13945 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2U30_13950 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C2U30_13955 ENOG4105EAB amino acid AbC transporter C2U30_13960 ENOG4105E5Q amino acid AbC transporter C2U30_13965 ENOG4105CDA abc transporter atp-binding protein C2U30_13970 ENOG4105VG0 50S ribosomal protein l34 C2U30_13975 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C2U30_13980 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C2U30_13985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2U30_13990 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C2U30_13995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U30_14045 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U30_14065 ENOG4105E4C Lytic transglycosylase catalytic C2U30_14150 ENOG4105DUM transcriptional regulator, lysR family C2U30_14155 ENOG41067TZ transcriptional regulator, MarR family C2U30_14175 ENOG4105E66 phosphoriboisomerase A C2U30_14190 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U30_14200 ENOG4105F04 LysR family Transcriptional regulator C2U30_14210 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U30_14215 ENOG4105CYM Glutathione S-transferase C2U30_14280 ENOG4105CHU acetyl-coa acetyltransferase C2U30_14305 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U30_14320 ENOG4105F6U Short-chain dehydrogenase reductase Sdr C2U30_14325 ENOG4108XFH Transcriptional regulator C2U30_14450 ENOG4105VXN addiction module toxin, RelE StbE family C2U30_14455 ENOG4108C33 Resolvase C2U30_14475 ENOG4105CAF HipA N-terminal domain protein C2U30_14480 ENOG4105S6R Iron-hydroxamate transporter permease subunit C2U30_14485 ENOG4105J76 Periplasmic binding protein C2U30_14490 ENOG4105E0A ABC, transporter C2U30_14495 ENOG4105IBP Cyclic peptide transporter C2U30_14500 ENOG4105E0K tonB-dependent siderophore receptor C2U30_14505 ENOG4105QTB Flavodoxin C2U30_14510 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C2U30_14515 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C2U30_14520 ENOG4107QJE Chromosome Partitioning Protein C2U30_14525 ENOG4105FA0 parb-like partition protein C2U30_14535 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) C2U30_14540 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U30_14545 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U30_14550 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U30_14555 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C2U30_14560 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C2U30_14565 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C2U30_14570 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C2U30_14575 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C2U30_14580 ENOG4105CT7 inner membrane cred family protein C2U30_14595 ENOG4105EB3 Histidine kinase C2U30_14600 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U30_14605 ENOG410804X Transcriptional regulator C2U30_14610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2U30_14615 ENOG4105VJY transcriptional regulator C2U30_14635 ENOG4109015 Biopolymer transport protein exbD tolR C2U30_14640 ENOG410822N TonB family C2U30_14680 ENOG4105DZC cytosine deaminase C2U30_14685 ENOG4105WMR Protein CrcB homolog C2U30_14695 ENOG4105JC1 sterol-binding domain protein C2U30_14700 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C2U30_14705 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C2U30_14710 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) C2U30_14715 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C2U30_14720 ENOG4105F8V Hydrolase, tatD family C2U30_14725 ENOG4105D52 delta-aminolevulinic acid dehydratase C2U30_14730 ENOG4105DGW oligopeptidase A C2U30_14735 ENOG4105BZU Histidine kinase C2U30_14740 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) C2U30_14750 ENOG4105C9X ppx gppa phosphatase C2U30_14755 ENOG4105C1J atp-dependent rna helicase C2U30_14760 ENOG4105K63 Thioredoxin C2U30_14765 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C2U30_14775 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C2U30_14780 ENOG4107QK7 reductase C2U30_14785 ENOG4105W0Z cytoplasmic protein C2U30_14800 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) C2U30_14815 ENOG4108IV0 ABC, transporter C2U30_14820 ENOG4105C0Z ABC transporter C2U30_14825 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U30_14830 ENOG4105C32 Amino acid ABC transporter (Permease) C2U30_14835 ENOG4105CP9 extracellular ligand-binding receptor C2U30_14840 ENOG4105ETE Transcriptional regulator (LacI family C2U30_14845 ENOG4108JUA Transcriptional regulator C2U30_14850 ENOG4105CNW domain protein C2U30_14855 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase C2U30_14865 ENOG4105HEE Binding Domain protein C2U30_14875 ENOG4105C0F tryptophanase EC 4.1.99.1 C2U30_14885 ENOG4105CIC tryptophan-specific transport protein C2U30_14905 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C2U30_14915 ENOG4108J1Q C2U30_14920 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C2U30_14925 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C2U30_14930 ENOG4108R3E Dna-3-methyladenine glycosylase i C2U30_14935 ENOG4105D3W isochorismatase C2U30_14950 ENOG4108ZG0 Ompa motb domain protein C2U30_14970 ENOG4105M4H endoribonuclease L-psp C2U30_14975 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C2U30_14990 ENOG4105E0F Histidine kinase C2U30_14995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U30_15000 ENOG4105CHU acetyl-coa acetyltransferase C2U30_15005 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U30_15010 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U30_15015 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) C2U30_15020 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C2U30_15025 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C2U30_15030 ENOG4108RR8 protoporphyrinogen oxidase C2U30_15060 ENOG4105CUZ uba thif-type nad fad binding protein C2U30_15065 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) C2U30_15070 ENOG4105C9B Cysteine desulfurase C2U30_15075 ENOG4105C4R Atp-dependent dna helicase C2U30_15080 ENOG4105BZU Histidine kinase C2U30_15085 ENOG4105MPD Cytochrome C2U30_15090 ENOG4105CPQ Dehydrogenase C2U30_15095 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C2U30_15100 ENOG41062JF Transcriptional regulator C2U30_15105 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C2U30_15120 ENOG4105W1T Glycosyl Transferase C2U30_15125 ENOG4108XNZ glycosyl transferase C2U30_15150 ENOG4105DIQ Transcriptional regulator C2U30_15170 ENOG4105X6C Flagellar basal body-associated protein FliL C2U30_15175 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C2U30_15180 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) C2U30_15190 ENOG4105E55 glycerol-3-phosphate acyltransferase C2U30_15195 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2U30_15210 ENOG4107R73 Mate efflux family protein C2U30_15215 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C2U30_15220 ENOG4105E0F Histidine kinase C2U30_15225 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U30_15230 ENOG41076HS cation diffusion facilitator family transporter C2U30_15235 ENOG4105D7W serine acetyltransferase C2U30_15245 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) C2U30_15250 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain C2U30_15255 ENOG4105C2M dna polymerase I C2U30_15260 ENOG4108Z0R Transferase C2U30_15295 ENOG4105CQ4 Transcriptional regulator C2U30_15300 ENOG4105CNT hydrolase family 2 C2U30_15305 ENOG4105FK9 beta-D-galactosidase beta subunit C2U30_15310 ENOG4105E5D amino acid C2U30_15315 ENOG4108Y51 tRNA-binding protein C2U30_15320 ENOG4105E5D amino acid C2U30_15325 ENOG4105DHU Bile acid C2U30_15345 ENOG4105C4W S-formylglutathione hydrolase C2U30_15355 ENOG4105CC0 LysR family Transcriptional regulator C2U30_15370 ENOG4105UIB (ABC) transporter C2U30_15375 ENOG4108JQ9 ABC transporter C2U30_15380 ENOG4105DIH basic membrane C2U30_15385 ENOG4105C4R Atp-dependent dna helicase C2U30_15420 ENOG4105HEI LysR family (Transcriptional regulator C2U30_15435 ENOG4105KVH Transcriptional regulator C2U30_15445 ENOG4105CHR reductase C2U30_15450 ENOG41061EV selenium-binding protein YdfZ C2U30_15470 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) C2U30_15480 ENOG4105ECQ AraC Family Transcriptional Regulator C2U30_15485 ENOG4105FR1 rard protein C2U30_15490 ENOG4105C26 Dehydrogenase C2U30_15495 ENOG4108JCI Transcriptional regulator C2U30_15505 ENOG4105C26 Dehydrogenase C2U30_15510 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U30_15515 ENOG4107R11 Transcriptional regulator C2U30_15520 ENOG4108MGF sugar kinase C2U30_15540 ENOG4105CGY Dna recombination protein C2U30_15545 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C2U30_15550 ENOG4105C1A potassium transporter peripheral membrane C2U30_15555 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2U30_15560 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C2U30_15565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2U30_15575 ENOG4105C79 DNA protecting protein DprA C2U30_15580 ENOG4108RPN Protein smg homolog C2U30_15585 ENOG4108WI1 Dna topoisomerase C2U30_15590 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U30_15595 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C2U30_15600 ENOG4105E2X shikimate dehydrogenase C2U30_15610 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C2U30_15615 ENOG4106RE7 Cytochrome C2U30_15620 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) C2U30_15625 ENOG4105XCT Protein of unknown function (DUF2489) C2U30_15630 ENOG4105D4P Coproporphyrinogen iii oxidase C2U30_15635 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C2U30_15640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U30_15645 ENOG4105CUX Signal transduction histidine kinase C2U30_15655 ENOG4105C5F glutamine synthetase C2U30_15665 ENOG4107S2Z UPF0761 membrane protein C2U30_15670 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C2U30_15680 ENOG4105SUU thioesterase domain C2U30_15690 ENOG4105CB5 ATP-dependent DNA helicase recG C2U30_15695 ENOG4105JIM Phosphatidylserine synthase C2U30_15700 ENOG4105C6Z Gluconate C2U30_15705 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family C2U30_15710 ENOG4105C01 Dihydroxy-acid dehydratase C2U30_15715 ENOG4108UHU Aldolase C2U30_15730 ENOG4105DIQ Transcriptional regulator C2U30_15740 ENOG41063SB peptidase C2U30_15745 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2U30_15750 ENOG4107YZP Rhodanese domain protein C2U30_15755 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) C2U30_15760 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C2U30_15765 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) C2U30_15770 ENOG4105MJ2 Competence protein C2U30_15775 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C2U30_15790 ENOG4105BZM domain protein C2U30_15800 ENOG4108RRZ Transcription elongation factor GreB C2U30_15805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U30_15810 ENOG4105E0F Histidine kinase C2U30_15820 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C2U30_15825 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C2U30_15830 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C2U30_15835 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C2U30_15840 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C2U30_15845 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C2U30_15850 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C2U30_15855 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C2U30_15860 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C2U30_15865 ENOG41083MP 50s ribosomal protein l29 C2U30_15870 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C2U30_15875 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C2U30_15880 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C2U30_15885 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C2U30_15890 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C2U30_15895 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C2U30_15900 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C2U30_15905 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C2U30_15910 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C2U30_15915 ENOG4105VPB 50S ribosomal protein L30 C2U30_15920 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C2U30_15925 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2U30_15930 ENOG41067V7 50S ribosomal protein L36 C2U30_15935 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C2U30_15940 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C2U30_15945 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C2U30_15950 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U30_15955 ENOG4108ZT0 50S ribosomal protein l17 C2U30_16025 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C2U30_16030 ENOG4106NZI LysR family Transcriptional regulator C2U30_16035 ENOG4105EMU Dehydrogenase C2U30_16050 ENOG4105CUG Oligopeptidase b C2U30_16070 ENOG4107FS9 Membrane C2U30_16085 ENOG4105CR8 Transcriptional regulator C2U30_16100 ENOG4105VVZ metal-binding protein C2U30_16105 ENOG41076UM multiple antibiotic resistance (MarC)-related protein C2U30_16115 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C2U30_16125 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C2U30_16130 ENOG4107RZC phospholipase d C2U30_16145 ENOG4105EJ2 Transcriptional regulator C2U30_16150 ENOG4108Y73 Membrane C2U30_16160 ENOG4106H78 methyltransferase C2U30_16165 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C2U30_16170 ENOG4105CAK Cell division ATP-binding protein ftsE C2U30_16175 ENOG4105CRP Part of the ABC transporter FtsEX involved in C2U30_16180 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U30_16185 ENOG41077A9 carbonic anhydrase C2U30_16190 ENOG4105CZE histidine utilization repressor C2U30_16200 ENOG4105CI2 imidazolone-5-propionate hydrolase C2U30_16205 ENOG41088SP formiminoglutamate hydrolase C2U30_16210 ENOG4105CGP Urocanate hydratase C2U30_16215 ENOG4105C84 Histidine ammonia-lyase C2U30_16225 ENOG4107XTP (EAL) domain protein C2U30_16265 ENOG4105GVR general secretion pathway protein D C2U30_16285 ENOG4105D7Q type ii secretion system C2U30_16330 ENOG4105DFF Rod shape-determining protein mreb C2U30_16335 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C2U30_16340 ENOG4105VQ7 Rod shape-determining protein MreD C2U30_16345 ENOG4108Z03 MAF-like protein C2U30_16350 ENOG4105C03 ribonuclease C2U30_16355 ENOG4105QD6 exported protein C2U30_16365 ENOG4105D1U peptidase U62 modulator of DNA gyrase C2U30_16370 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) C2U30_16380 ENOG4105FCK Membrane C2U30_16385 ENOG4105C5Y PTS System C2U30_16390 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C2U30_16405 ENOG4105CSH Transporter C2U30_16415 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U30_16420 ENOG4105BZU Histidine kinase C2U30_16425 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C2U30_16430 ENOG4107MMM Anti-sigma-factor antagonist C2U30_16435 ENOG4107SDU Methyl-accepting chemotaxis C2U30_16440 ENOG4105F0S class B acid phosphatase C2U30_16445 ENOG4105CGZ zinc metallopeptidase C2U30_16465 ENOG4105EEQ Na H antiporter C2U30_16470 ENOG4105C3R Methionine synthase C2U30_16480 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C2U30_16490 ENOG4105ETX regulatoR C2U30_16505 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C2U30_16510 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C2U30_16515 ENOG4105D06 uba thif-type nad fad binding protein C2U30_16525 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C2U30_16530 ENOG4105D41 biosynthesis protein thiH C2U30_16555 ENOG4105EQK -acetyltransferase C2U30_16560 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) C2U30_16565 ENOG4105BZU Histidine kinase C2U30_16570 ENOG4108TPP exopolysaccharide synthesis C2U30_16580 ENOG4105N0V mono-oxygenase ydhR C2U30_16585 ENOG4105KVH Transcriptional regulator C2U30_16600 ENOG4105E0K tonB-dependent siderophore receptor C2U30_16610 ENOG4105DMQ Methyltransferase C2U30_16620 ENOG4105CBT Fructose-1,6-bisphosphatase C2U30_16625 ENOG4105KRS Proteinase inhibitor C2U30_16630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2U30_16635 ENOG4105VFK BolA family C2U30_16645 ENOG4105E3I toluene tolerance C2U30_16650 ENOG4107PE3 Mammalian cell entry related domain protein C2U30_16655 ENOG4105CY3 ABC transporter, permease C2U30_16660 ENOG4105DHJ ABC, transporter C2U30_16665 ENOG4105C2X Arabinose 5-phosphate isomerase C2U30_16670 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase C2U30_16680 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA C2U30_16685 ENOG4108IUZ ABC transporter C2U30_16690 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U30_16695 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA C2U30_16700 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C2U30_16705 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C2U30_16710 ENOG41080Z8 PHOSPHOCARRIER protein C2U30_16715 ENOG4105CTS PTS system mannitol-specific C2U30_16730 ENOG41069H0 dihydroorotase EC 3.5.2.3 C2U30_16760 ENOG4105C0H protease C2U30_16765 ENOG4105C0H protease C2U30_16775 ENOG4105D6Z AFG1 family ATPase C2U30_16780 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C2U30_16785 ENOG4108UJD 30S ribosomal protein S9 C2U30_16790 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U30_16795 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U30_16800 ENOG4105EIX cytochrome c1 C2U30_16805 ENOG4107MKT Stringent starvation protein a C2U30_16810 ENOG4105KB2 stringent starvation protein b C2U30_16815 ENOG4105W4M Transport-associated protein C2U30_16820 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C2U30_16825 ENOG41082RQ UPF0102 protein C2U30_16830 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) C2U30_16835 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C2U30_16845 ENOG4108V6E Cell division protein mraZ C2U30_16850 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C2U30_16855 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C2U30_16860 ENOG4105CJN penicillin-binding protein C2U30_16865 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2U30_16870 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C2U30_16875 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C2U30_16880 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C2U30_16885 ENOG4105CNI cell division protein FtsW C2U30_16890 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C2U30_16895 ENOG4105DFU Cell wall formation (By similarity) C2U30_16900 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C2U30_16905 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2U30_16910 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C2U30_16915 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U30_16925 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C2U30_16935 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2U30_16940 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) C2U30_16945 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) C2U30_16960 ENOG4105D7Q type ii secretion system C2U30_16965 ENOG4107QHF type ii secretion system protein e C2U30_16980 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C2U30_17000 ENOG41073TP transcriptional regulator C2U30_17005 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U30_17010 ENOG4107QSN dihydrolipoamide acetyltransferase C2U30_17015 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U30_17025 ENOG4108N3W hemolysin secretion protein C2U30_17030 ENOG4108N3W hemolysin secretion protein C2U30_17035 ENOG4105D78 K07001 NTE family protein C2U30_17040 ENOG4107QIJ Aconitate hydratase 2 C2U30_17045 ENOG4105BZU Histidine kinase C2U30_17055 ENOG4105E82 cytochrome subunit of dehydrogenase C2U30_17065 ENOG4105CKI cobalamin synthesis protein C2U30_17070 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U30_17080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2U30_17085 ENOG4107ZVW dihydroneopterin aldolase C2U30_17090 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2U30_17135 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C2U30_17145 ENOG4107TH8 cina domain protein C2U30_17150 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C2U30_17155 ENOG4105Y3E Modulates RecA activity (By similarity) C2U30_17160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U30_17165 ENOG4105CFH Aspartokinase C2U30_17170 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C2U30_17205 ENOG41061WM D-Alanyl-D-Alanine C2U30_17210 ENOG4106W5V Membrane C2U30_17220 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C2U30_17225 ENOG4105MYG DNA polymerase iii, chi subunit C2U30_17230 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U30_17235 ENOG4108M8S permease YjgP YjgQ family protein C2U30_17240 ENOG4108K5H permease YjgP YjgQ family protein C2U30_17255 ENOG4108KU3 Integrase C2U30_17325 ENOG4107SID ATP-dependent exodnase (exonuclease v) C2U30_17365 ENOG4105BZU Histidine kinase C2U30_17370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2U30_17385 ENOG4105EYA deoxyribonuclease C2U30_17390 ENOG4105D9N nucleoside C2U30_17400 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C2U30_17405 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C2U30_17410 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C2U30_17415 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C2U30_17430 ENOG4105EAC phosphoserine phosphatase C2U30_17445 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C2U30_17455 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor C2U30_17460 ENOG4105K70 DNA-binding protein C2U30_17475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U30_17480 ENOG4105MYN Zinc uptake regulation protein C2U30_17495 ENOG4105CWM branched-chain amino acid transport system II carrier protein C2U30_17500 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) C2U30_17505 ENOG4105C1J atp-dependent rna helicase C2U30_17510 ENOG4105D1Q UPF0246 protein C2U30_17515 ENOG4105CZX twitching motility protein C2U30_17520 ENOG4105CZX twitching motility protein C2U30_17525 ENOG4105DFA alanine racemase domain protein C2U30_17530 ENOG4105II7 pyrroline-5-carboxylate reductase C2U30_17535 ENOG4108VIA integral membrane protein C2U30_17540 ENOG4105VZ9 UPF0235 protein C2U30_17565 ENOG4105XTV UPF0231 protein C2U30_17570 ENOG4107VHA regulatoR C2U30_17575 ENOG4107QQ0 gntp family C2U30_17580 ENOG4105BZW Glycerate kinase C2U30_17595 ENOG4105HEI LysR family (Transcriptional regulator C2U30_17600 ENOG4105D9N nucleoside C2U30_17615 ENOG4108YZN class I peptide chain release factor C2U30_17620 ENOG4108YZA Nitrogen regulatory protein pii C2U30_17625 ENOG4107QKW extracellular solute-binding protein family 1 C2U30_17635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U30_17640 ENOG4105EZR dyp-type peroxidase family protein C2U30_17645 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) C2U30_17650 ENOG4105E5Z arginine transporter ATP-binding subunit C2U30_17655 ENOG4106TNF Periplasmic binding protein C2U30_17660 ENOG4105GBT ABC transporter C2U30_17665 ENOG4105DMR ABC, transporter C2U30_17670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2U30_17680 ENOG4108UV7 flagellar protein motX C2U30_17685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C2U30_17695 ENOG4108JU6 CBS domain protein C2U30_17700 ENOG4106KVJ cytochrome C assembly protein C2U30_17705 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C2U30_17715 ENOG4105K5M 30s ribosomal protein S16 C2U30_17720 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C2U30_17725 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C2U30_17730 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C2U30_17740 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) C2U30_17745 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2U30_17750 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase C2U30_17755 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C2U30_17760 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C2U30_17765 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C2U30_17775 ENOG41063Z6 transcriptional regulator, lysR family C2U30_17780 ENOG41080HT Transcriptional regulator, arsr family C2U30_17785 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C2U30_17790 ENOG4105CJR Integral membrane protein (MviN C2U30_17795 ENOG4105DTN riboflavin biosynthesis protein ribF C2U30_17800 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2U30_17805 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C2U30_17810 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C2U30_17815 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C2U30_17820 ENOG4106855 Competence protein C2U30_17860 ENOG4105C4K Nad synthetase C2U30_17865 ENOG4108YZA Nitrogen regulatory protein pii C2U30_17875 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C2U30_17880 ENOG4106TD9 Diguanylate cyclase C2U30_17885 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C2U30_17890 ENOG4105C2N RNA methyltransferase TrmH family group 3 C2U30_17900 ENOG4107YB6 acetyltransferase, (GNAT) family C2U30_17905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U30_17910 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2U30_17915 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C2U30_17920 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C2U30_17925 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C2U30_17930 ENOG4105DP0 ferredoxin-NADP reductase C2U30_17950 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C2U30_17965 ENOG4105W39 Membrane C2U30_17975 ENOG4105D9M gamma-glutamylcysteine synthetase C2U30_17980 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2U30_17985 ENOG4108IJ0 Aspartate ammonia-lyase C2U30_17990 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 C2U30_18000 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C2U30_18005 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C2U30_18015 ENOG4105BZU Histidine kinase C2U30_18025 ENOG4105D3G Pseudouridine synthase C2U30_18030 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) C2U30_18060 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2U30_18070 ENOG4108I5D sulfate abc transporter C2U30_18075 ENOG4105ECW sulfate abc transporter C2U30_18080 ENOG4108IJ6 ABC transporter C2U30_18085 ENOG4107R11 Transcriptional regulator C2U30_18090 ENOG4108M1A Chitin-binding protein C2U30_18095 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_18120 ENOG4105G0K glycine radical enzyme YjjI family C2U30_18125 ENOG41076CZ activating enzyme C2U30_18140 ENOG4105CGF Aromatic amino acid aminotransferase C2U30_18145 ENOG4105D1V cellulose synthase operon protein YhjU C2U30_18155 ENOG4105UTS cellulose synthase operon protein YhjQ C2U30_18160 ENOG4107QZ7 Cellulose synthase catalytic subunit C2U30_18165 ENOG4107EEX Cellulose synthase regulator protein C2U30_18175 ENOG4105EJG cellulose synthase C2U30_18180 ENOG4105EJG cellulose synthase C2U30_18210 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C2U30_18215 ENOG4105C1J atp-dependent rna helicase C2U30_18220 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U30_18230 ENOG4107QSI ABC, transporter C2U30_18240 ENOG4105EQK -acetyltransferase C2U30_18245 ENOG4106WH9 Protein of unknown function (DUF2753) C2U30_18250 ENOG4105E39 Enoyl-CoA hydratase C2U30_18265 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr C2U30_18270 ENOG41083X2 DNA polymerase III, epsilon subunit C2U30_18275 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2U30_18280 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_18285 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C2U30_18290 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C2U30_18295 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U30_18300 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U30_18310 ENOG4105KJB cyd operon protein YbgE C2U30_18315 ENOG4107YD3 Thioesterase C2U30_18320 ENOG4105E02 MotA TolQ exbB proton channel C2U30_18325 ENOG4105M8F Biopolymer transport protein exbD tolR C2U30_18335 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C2U30_18340 ENOG4105KCK Peptidoglycan-associated lipoprotein C2U30_18345 ENOG4105UFD tol-pal system protein YbgF C2U30_18420 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_18425 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C2U30_18430 ENOG4105DSB aldose 1-epimerase C2U30_18440 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) C2U30_18445 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C2U30_18455 ENOG4105E0X reductase C2U30_18475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C2U30_18480 ENOG4105K56 Transcriptional regulator C2U30_18495 ENOG4105EW9 transcriptional regulator AsnC family C2U30_18510 ENOG4108K4B hydrolase C2U30_18525 ENOG4105C8J )-transporter C2U30_18530 ENOG4105C8J )-transporter C2U30_18545 ENOG4107SQD Transcriptional regulator, GntR family C2U30_18570 ENOG4108IQE Amp-dependent synthetase and ligase C2U30_18580 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C2U30_18595 ENOG4105EV2 VWA domain protein interacting with AAA ATPase C2U30_18600 ENOG4105BZU Histidine kinase C2U30_18605 ENOG4105BZU Histidine kinase C2U30_18620 ENOG4105KD7 acetyltransferase C2U30_18630 ENOG4108MJ3 acetyltransferase C2U30_18635 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U30_18650 ENOG4105DWY Agmatine deiminase C2U30_18655 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U30_18660 ENOG4108J1Q C2U30_18680 ENOG4106AXJ AraC family transcriptional regulator C2U30_18690 ENOG4105C1J atp-dependent rna helicase C2U30_18695 ENOG4105BZU Histidine kinase C2U30_18700 ENOG4107Y60 (LipO)protein C2U30_18710 ENOG4106B0W Curli production assembly transport component CsgG C2U30_18730 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase C2U30_18745 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U30_18750 ENOG4105DJY efflux transporter, rnd family, mfp subunit C2U30_18755 ENOG4105E3W Two component transcriptional regulator (Winged helix family C2U30_18760 ENOG4105E0F Histidine kinase C2U30_18785 ENOG4107QWG 2-Nitropropane dioxygenase C2U30_18815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U30_18825 ENOG4108IAB Phoh family C2U30_18830 ENOG4107T0D ABC, transporter C2U30_18835 ENOG4106SMU thiamine transporter membrane protein C2U30_18840 ENOG4105DP9 ABC transporter C2U30_18855 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U30_18860 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U30_18870 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2U30_18895 ENOG4105C7K acetolactate synthase C2U30_18905 ENOG4108ZP8 Acetolactate synthase small subunit C2U30_18910 ENOG4105C6K Malic enzyme C2U30_18915 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2U30_18920 ENOG4105PQ6 UPF0208 membrane protein C2U30_18925 ENOG4105XWI UPF0304 protein C2U30_18930 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U30_18935 ENOG4105RH4 Glycine cleavage system transcriptional repressor C2U30_18940 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U30_18945 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U30_18950 ENOG4107QWK SAICAR synthetase C2U30_18960 ENOG4105EXG Transcriptional regulator C2U30_18965 ENOG4108Q67 UPF0319 protein C2U30_18985 ENOG4105BZU Histidine kinase C2U30_19000 ENOG4105BZU Histidine kinase C2U30_19005 ENOG4105BZU Histidine kinase C2U30_19010 ENOG4107SDU Methyl-accepting chemotaxis C2U30_19015 ENOG4105MDZ Transcriptional activator rfaH C2U30_19020 ENOG4105D01 (LipO)protein C2U30_19025 ENOG4108UMI ABC transporter, permease C2U30_19030 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U30_19050 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C2U30_19055 ENOG4105K8N protein family UPF0079, ATPase C2U30_19060 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2U30_19065 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C2U30_19070 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C2U30_19075 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2U30_19080 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2U30_19085 ENOG4107QJR hflk protein C2U30_19090 ENOG4105EPW hflc protein C2U30_19100 ENOG4105EAH synthase C2U30_19105 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C2U30_19110 ENOG4105K46 50S ribosomal protein l27 C2U30_19115 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C2U30_19120 ENOG4105DWD nucleoside recognition domain protein C2U30_19125 ENOG4108ESY Metal dependent phosphohydrolase C2U30_19130 ENOG4105DEN Luciferase family C2U30_19140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2U30_19145 ENOG4105NWN ApaG protein C2U30_19150 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C2U30_19155 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2U30_19165 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C2U30_19170 ENOG4105EHM Aminoglycoside phosphotransferase C2U30_19175 ENOG4108S0S Nucleotidyl transferase C2U30_19180 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) C2U30_19190 ENOG4105C7N Xanthine uracil vitamin C permease C2U30_19200 ENOG4105C5H ABC transporter C2U30_19205 ENOG4107R08 Integrase C2U30_19215 ENOG4108UUM single-stranded DNA-binding protein C2U30_19405 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U30_19410 ENOG4105KT5 UmuD protein C2U30_19415 ENOG4108RAV Conserved protein C2U30_19455 ENOG4105CAR Terminase, large subunit C2U30_19470 ENOG4105D07 Signal peptide peptidase, SppA C2U30_19575 ENOG4105E4C Lytic transglycosylase catalytic C2U30_19595 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C2U30_19605 ENOG4105C6Y Udp-glucose 6-dehydrogenase C2U30_19620 ENOG4105EHG Permease protein C2U30_19630 ENOG41090JE Utilization Protein C2U30_19635 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related C2U30_19660 ENOG4105D8G Major Facilitator superfamily C2U30_19665 ENOG4105BZU Histidine kinase C2U30_19675 ENOG4105DHI Methyltransferase C2U30_19680 ENOG4107RYR Transcriptional regulator, Crp Fnr family C2U30_19685 ENOG4108UKZ OsmC family C2U30_19700 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) C2U30_19705 ENOG4105YP7 UPF0270 protein C2U30_19715 ENOG4105DNZ Alpha Beta Hydrolase C2U30_19720 ENOG4107R88 Chemotaxis protein (CheV) C2U30_19730 ENOG4105VKU nucleicacid-binding protein C2U30_19735 ENOG4108YZY peptidylprolyl cis-trans isomerase C2U30_19740 ENOG4105VRX Protein slyX homolog C2U30_19750 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U30_19755 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U30_19775 ENOG4105CGH 5'-nucleotidase C2U30_19785 ENOG4105CDU Replicative dna helicase C2U30_19790 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U30_19795 ENOG4105C26 Dehydrogenase C2U30_19815 ENOG4105CW7 secretion protein, HlyD family C2U30_19820 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U30_19825 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) C2U30_19830 ENOG4108ZXC Two component transcriptional regulator, luxr family C2U30_19835 ENOG4105BZU Histidine kinase C2U30_19840 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U30_19845 ENOG4106WHD Tetrathionate reductase C2U30_19860 ENOG4108NJZ Sensory box GGDEF EAL domain protein C2U30_19885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U30_19895 ENOG4105N14 lysine exporter protein LysE YggA C2U30_19900 ENOG4105CFP Peptidase U32 C2U30_19910 ENOG4105XDF Protein of unknown function (DUF1272) C2U30_19930 ENOG4105CTD carboxy-peptidase C2U30_19955 ENOG4105E1F short-chain dehydrogenase reductase C2U30_19965 ENOG4108W2P Methyl-accepting chemotaxis C2U30_19975 ENOG4105C6Z Gluconate C2U30_19980 ENOG4105EXW epimerase dehydratase C2U30_19985 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C2U30_19990 ENOG4105FB2 class II Aldolase C2U30_19995 ENOG4105G63 Type III effector Hrp-dependent C2U30_20005 ENOG4105MVE transcriptional regulator C2U30_20015 ENOG4105D8V Glucose sorbosone dehydrogenase C2U30_20050 ENOG4105CQC Prephenate dehydratase C2U30_20075 ENOG4107SEY Conserved Protein C2U30_20080 ENOG4108XDN Transcriptional regulator C2U30_20085 ENOG4105CVP deoxyribo-dipyrimidine photolyase C2U30_20095 ENOG4105EMU Dehydrogenase C2U30_20110 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2U30_20135 ENOG4108RMU ferritin dps family protein C2U30_20140 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C2U30_20150 ENOG4105CMR udp-glucose 4-epimerase C2U30_20170 ENOG4105VCP PTS System C2U30_20175 ENOG4105CS2 ec 3.2.1.21 C2U30_20185 ENOG4105VZJ PTS System C2U30_20190 ENOG4105E08 Glycoside hydrolase, family 9 C2U30_20205 ENOG4107FKK extracellular solute-binding protein family 1 C2U30_20210 ENOG4105ETE Transcriptional regulator (LacI family C2U30_20230 ENOG4105BZS acriflavin resistance protein C2U30_20235 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U30_20245 ENOG4105BZU Histidine kinase C2U30_20250 ENOG4105CHH sulfate transporter C2U30_20255 ENOG4107S0N DJ-1 family C2U30_20260 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C2U30_20265 ENOG4108VPT UPF0234 protein C2U30_20270 ENOG4105DRB nucleoside-specific channel-forming protein C2U30_20275 ENOG4105EYM Major Facilitator superfamily C2U30_20285 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C2U30_20295 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C2U30_20300 ENOG4105M85 Bola protein C2U30_20305 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_20310 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_20315 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_20320 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_20325 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C2U30_20330 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) C2U30_20335 ENOG4105CJ2 (LipO)protein C2U30_20350 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U30_20355 ENOG4105C8Q Methyl-accepting chemotaxis C2U30_20360 ENOG4105ETT transcriptional Regulator, LysR family C2U30_20375 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) C2U30_20385 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2U30_20390 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease C2U30_20395 ENOG4105EWT decarboxylase family C2U30_20400 ENOG4105BZU Histidine kinase C2U30_20410 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C2U30_20415 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) C2U30_20420 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein C2U30_20445 ENOG4105WP7 tRNA pseudouridine synthase C C2U30_20450 ENOG4105DR9 pseudouridine synthase C2U30_20455 ENOG4105QTB Flavodoxin C2U30_20465 ENOG4107W52 maltose operon periplasmic protein C2U30_20470 ENOG4105CI1 PTS System C2U30_20475 ENOG4108T8E UPF0325 protein C2U30_20480 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C2U30_20485 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C2U30_20490 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2U30_20495 ENOG4105CE9 30S ribosomal protein S2 C2U30_20500 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C2U30_20505 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2U30_20510 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C2U30_20515 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2U30_20520 ENOG4105KNE Phosphatidate cytidylyltransferase C2U30_20525 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2U30_20530 ENOG4105DZP Membrane-associated zinc metalloprotease C2U30_20540 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) C2U30_20545 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U30_20550 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C2U30_20555 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U30_20560 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U30_20565 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U30_20570 ENOG4105C0B DNA polymerase III (alpha subunit) C2U30_20575 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C2U30_20585 ENOG4105EQ2 LysR family Transcriptional regulator C2U30_20590 ENOG4105C44 Serine transporter C2U30_20595 ENOG4105DVH amino acid C2U30_20610 ENOG4105C5H ABC transporter C2U30_20620 ENOG4105C9K Endothelin-converting enzyme 1 C2U30_20625 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C2U30_20630 ENOG4105BZU Histidine kinase C2U30_20660 ENOG4108W5X Transcriptional Regulator, LuxR family C2U30_20670 ENOG4107T9C Alpha amylase catalytic region C2U30_20700 ENOG4105DIT ErfK YbiS YcfS YnhG family protein C2U30_20705 ENOG4105EAQ (twin-arginine translocation) pathway signal C2U30_20715 ENOG4105EN6 Membrane C2U30_20720 ENOG4105EXN Sulfate transport protein CysZ C2U30_20730 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) C2U30_20735 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2U30_20745 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C2U30_20750 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) C2U30_20775 ENOG4105J12 Multidrug resistance protein mdtN C2U30_20785 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C2U30_20790 ENOG4106YYS transcriptional regulatory protein C2U30_20800 ENOG4105CPC Aldo Keto reductase C2U30_20805 ENOG4108IPJ Membrane C2U30_20815 ENOG4105C26 Dehydrogenase C2U30_20820 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C2U30_20825 ENOG4105BZU Histidine kinase C2U30_20830 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase C2U30_20835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U30_20840 ENOG4105BZU Histidine kinase C2U30_20850 ENOG4105ERG peptidase m48, ste24p C2U30_20860 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) C2U30_20865 ENOG4106N3A copper homeostasis protein cutc C2U30_20875 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U30_20880 ENOG4105CJ1 ABC, transporter C2U30_20900 ENOG4105EZ7 amino acid ABC transporter C2U30_20905 ENOG4105DRP amino acid AbC transporter C2U30_20910 ENOG4105CDA abc transporter atp-binding protein C2U30_20920 ENOG4105PTV Nudix Hydrolase C2U30_20945 ENOG4105UYK outer membrane protein a C2U30_20960 ENOG4105C8J )-transporter C2U30_20965 ENOG4105D78 K07001 NTE family protein C2U30_20970 ENOG4105BZU Histidine kinase C2U30_20980 ENOG4105BZS acriflavin resistance protein C2U30_20985 ENOG4105CCT upf0313 protein C2U30_21020 ENOG4105EP9 oxidoreductase C2U30_21025 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C2U30_21030 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C2U30_21045 ENOG4105E4C Lytic transglycosylase catalytic C2U30_21070 ENOG4105CIY formyltetrahydrofolate deformylase C2U30_21075 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2U30_21085 ENOG4107QR8 Thioredoxin C2U30_21090 ENOG4107YAK holo-(acyl carrier protein) synthase 2 C2U30_21095 ENOG4107TT5 NLP P60 protein C2U30_21100 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) C2U30_21115 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2U30_21125 ENOG4105BZU Histidine kinase C2U30_21145 ENOG4105XIQ Protein of unknown function (DUF2517) C2U30_21150 ENOG4105BZU Histidine kinase C2U30_21155 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C2U30_21160 ENOG4108V1T peptidylprolyl cis-trans isomerase C2U30_21175 ENOG4105CUB amino acid C2U30_21180 ENOG4105CUB amino acid C2U30_21190 ENOG4108JPW Aminotransferase C2U30_21195 ENOG4105C26 Dehydrogenase C2U30_21200 ENOG4107VRI Transcriptional regulator C2U30_21205 ENOG4105CJP fad dependent oxidoreductase C2U30_21240 ENOG4105CKD glutathione-regulated potassium-efflux system protein C2U30_21245 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U30_21255 ENOG4105DH7 May be involved in recombination (By similarity) C2U30_21260 ENOG4105WCN acetyltransferase C2U30_21265 ENOG4107RH8 nuclease SbcCD subunit D C2U30_21270 ENOG4105EYH Exonuclease C2U30_21275 ENOG4105CPW cytochrome b561 C2U30_21280 ENOG4105C5Y PTS System C2U30_21290 ENOG4105KZ7 phosphocarrier protein hpr C2U30_21295 ENOG4105C6T cysteine synthase C2U30_21300 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2U30_21315 ENOG4108R96 Methyltransferase, YaeB family C2U30_21335 ENOG4108JJ8 (ABC) transporter C2U30_21340 ENOG4108JJ9 ABC, transporter C2U30_21355 ENOG41065U4 response regulator C2U30_21365 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C2U30_21380 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) C2U30_21385 ENOG4106FVC RNA methyltransferase C2U30_21400 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C2U30_21405 ENOG4105D98 threonine synthase C2U30_21435 ENOG4105E18 UPF0276 protein C2U30_21455 ENOG4107SDU Methyl-accepting chemotaxis C2U30_21465 ENOG4108ESY Metal dependent phosphohydrolase C2U30_21470 ENOG4105DR8 Membrane C2U30_21475 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C2U30_21480 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C2U30_21485 ENOG4107R1I NAD-dependent malic enzyme C2U30_21495 ENOG4105C2W permease C2U30_21515 ENOG4105EGS Mechanosensitive ion channel C2U30_21520 ENOG4105CA9 Pyruvate kinase C2U30_21525 ENOG4105EZE Cupin 4 family protein C2U30_21530 ENOG4107QTF adenylosuccinate lyase C2U30_21535 ENOG41075W9 High frequency lysogenization protein HflD homolog C2U30_21540 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C2U30_21550 ENOG4108R99 pseudouridine synthase C2U30_21590 ENOG4108HMX isocitrate dehydrogenase (NADP) C2U30_21600 ENOG4105BZC d-serine deaminase C2U30_21605 ENOG4105W8I Transcriptional regulator C2U30_21620 ENOG4105Q26 Siderophore-interacting protein C2U30_21625 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U30_21630 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U30_21635 ENOG4105DJY efflux transporter, rnd family, mfp subunit C2U30_21645 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C2U30_21650 ENOG4105BZU Histidine kinase C2U30_21655 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C2U30_21660 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C2U30_21665 ENOG4105CFG Acts as a chaperone (By similarity) C2U30_21670 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2U30_21680 ENOG4105D7K pfkb domain protein C2U30_21695 ENOG4105WBN Transcriptional regulator (LacI family C2U30_21710 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase C2U30_21720 ENOG41080HT Transcriptional regulator, arsr family C2U30_21730 ENOG4105KFG YeeE YedE family protein C2U30_21745 ENOG4105BZU Histidine kinase C2U30_21750 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) C2U30_21765 ENOG4108IJF Heavy metal efflux pump, CzcA C2U30_21770 ENOG4105EP1 Efflux transporter rnd family, mfp subunit C2U30_21780 ENOG4105CGK Exodeoxyribonuclease III C2U30_21805 ENOG41090JD Blue (Type 1) copper domain protein C2U30_21820 ENOG4105NTK Transcriptional repressor Mpra C2U30_21840 ENOG4105CC0 LysR family Transcriptional regulator C2U30_21845 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U30_21850 ENOG4105E2S oxidase) subunit II C2U30_21855 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2U30_21860 ENOG4105CCU oxidase (Subunit III) C2U30_21865 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C2U30_21870 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2U30_21880 ENOG4107RDB Major Facilitator C2U30_21885 ENOG4105KCV RNA signal recognition particle 4.5S RNA C2U30_21895 ENOG4105CC0 LysR family Transcriptional regulator C2U30_21915 ENOG4105CAF HipA N-terminal domain protein C2U30_21945 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C2U30_21950 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C2U30_21955 ENOG4105DK0 Indole-3-glycerol phosphate synthase C2U30_21960 ENOG4108I0Q anthranilate phosphoribosyltransferase C2U30_21965 ENOG4108EFP Anthranilate synthase component II C2U30_21970 ENOG4105CRQ synthase (Component I) C2U30_21980 ENOG4105DB7 PHP domain protein C2U30_21985 ENOG4107RTD sua5 ycio yrdc ywlc family protein C2U30_21995 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C2U30_22000 ENOG4105FE9 pseudouridine synthase C2U30_22005 ENOG4105C29 acyl-CoA thioesterase C2U30_22020 ENOG4108IG5 Transcriptional regulator C2U30_22025 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U30_22030 ENOG4105BZS acriflavin resistance protein C2U30_22035 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U30_22040 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2U30_22115 ENOG4107SSZ Phosphatase C2U30_22125 ENOG4107QPN acyl-Coa dehydrogenase C2U30_22130 ENOG4105BZS acriflavin resistance protein C2U30_22140 ENOG4105CA9 Pyruvate kinase C2U30_22145 ENOG4106KNT transcriptional regulator C2U30_22155 ENOG4105IFJ Histidine kinase C2U30_22160 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U30_22165 ENOG4105C1B dTDP-glucose 4-6-dehydratase C2U30_22170 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2U30_22180 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C2U30_22200 ENOG4105EGZ biosynthesis protein C2U30_22210 ENOG4108UW5 maltose o-acetyltransferase C2U30_22215 ENOG4108TMJ glycosyl transferase C2U30_22220 ENOG4108RT7 Glycosyl transferase, family 2 C2U30_22230 ENOG4105ESV Glycosyl transferase, family 4 C2U30_22240 ENOG4108QY5 Ferric enterobactin transport protein C2U30_22255 ENOG4108YXG UPF0502 protein C2U30_22265 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) C2U30_22280 ENOG4107RUY (E1 component), alpha subunit C2U30_22285 ENOG4105CPP Dehydrogenase, E1 component C2U30_22290 ENOG4107QSN dihydrolipoamide acetyltransferase C2U30_22295 ENOG4105VEQ Cold shock protein C2U30_22320 ENOG4105E43 Extracellular solute-binding protein, family 5 C2U30_22325 ENOG4108594 Permease of the drug metabolite transporter C2U30_22335 ENOG4105DHT Metal Dependent Phosphohydrolase C2U30_22345 ENOG4105I08 Pseudouridine synthase C2U30_22355 ENOG4107QSI ABC, transporter C2U30_22360 ENOG4108RE9 Phosphodiesterase C2U30_22380 ENOG4107ESN Flagella basal body P-ring formation protein flgA C2U30_22385 ENOG4107R88 Chemotaxis protein (CheV) C2U30_22390 ENOG4105BZU Histidine kinase C2U30_22395 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2U30_22400 ENOG4108ZC9 flagellar basal-body rod protein flgc C2U30_22410 ENOG4105BZE flagellar hook protein, FlgE C2U30_22415 ENOG4108KPB Flagellar basal-body rod protein FlgF C2U30_22420 ENOG4105CGA flagellar basal-body rod protein FlgG C2U30_22425 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U30_22430 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U30_22435 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C2U30_22440 ENOG410829K Lysine exporter protein (Lyse ygga) C2U30_22480 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U30_22535 ENOG4107SKI cobyrinic Acid a,c-diamide synthase