locus-tag	class	description
C2U30_00015	COG2239	Acts as a magnesium transporter
C2U30_00020	COG0248	Ppx GppA phosphatase
C2U30_00025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U30_00030	COG2716	regulation of RNA biosynthetic process
C2U30_00040	COG2204	response regulator
C2U30_00045	COG3852	Histidine kinase
C2U30_00050	COG2204	response regulator
C2U30_00055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U30_00060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U30_00065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U30_00070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U30_00090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U30_00105	COG0590	tRNA wobble adenosine to inosine editing
C2U30_00110	COG0573	inorganic phosphate transmembrane transporter activity
C2U30_00115	COG0581	inorganic phosphate transmembrane transporter activity
C2U30_00125	COG0704	Plays a role in the regulation of phosphate uptake
C2U30_00130	COG1253	flavin adenine dinucleotide binding
C2U30_00145	COG0531	amino acid
C2U30_00155	COG1126	abc transporter atp-binding protein
C2U30_00160	COG0765	amino acid transport
C2U30_00165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_00175	COG3706	GGDEF domain
C2U30_00180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U30_00200	COG1785	Belongs to the alkaline phosphatase family
C2U30_00205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U30_00210	COG0477	Major facilitator Superfamily
C2U30_00215	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U30_00225	COG1199	ATP-dependent helicase activity
C2U30_00240	COG1448	Aminotransferase
C2U30_00245	COG0433	COG0433 Predicted ATPase
C2U30_00260	COG0658	competence protein
C2U30_00260	COG2333	competence protein COMEC
C2U30_00265	COG1132	(ABC) transporter
C2U30_00270	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U30_00275	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U30_00280	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U30_00285	COG2197	response regulator
C2U30_00290	COG0322	excinuclease ABC activity
C2U30_00330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U30_00345	COG0583	DNA-binding transcription factor activity
C2U30_00350	COG0402	S-adenosylhomocysteine deaminase activity
C2U30_00360	COG0604	alcohol dehydrogenase
C2U30_00365	COG1309	transcriptional regulator
C2U30_00370	COG2261	transglycosylase associated protein
C2U30_00375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U30_00385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U30_00420	COG2801	Transposase and inactivated derivatives
C2U30_00435	COG2203	Gaf domain
C2U30_00435	COG2199	diguanylate cyclase activity
C2U30_00470	COG2119	membrane
C2U30_00475	COG0023	Translation Initiation Factor
C2U30_00485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2U30_00510	COG4139	cobalamin transport
C2U30_00515	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U30_00525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U30_00530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U30_00535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U30_00540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U30_00545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U30_00555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U30_00560	COG0505	Belongs to the CarA family
C2U30_00565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U30_00570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U30_00575	COG3706	GGDEF domain
C2U30_00615	COG4104	PAAR repeat-containing protein
C2U30_00630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_00635	COG0765	amino acid transport
C2U30_00645	COG0493	'glutamate synthase
C2U30_00650	COG0070	glutamate synthase
C2U30_00650	COG0069	glutamate synthase activity
C2U30_00650	COG0067	glutamate synthase
C2U30_00655	COG1242	4 iron, 4 sulfur cluster binding
C2U30_00700	COG1113	amino acid transport
C2U30_00710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U30_00715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U30_00715	COG0574	Belongs to the PEP-utilizing enzyme family
C2U30_00720	COG1119	ATPase activity
C2U30_00750	COG1464	Belongs to the NlpA lipoprotein family
C2U30_00760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U30_00765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U30_00775	COG0101	tRNA pseudouridine synthase activity
C2U30_00780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U30_00785	COG0285	dihydrofolate synthase activity
C2U30_00790	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U30_00795	COG2920	part of a sulfur-relay system
C2U30_00800	COG1289	transmembrane transporter activity
C2U30_00805	COG0670	Belongs to the BI1 family
C2U30_00845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U30_00855	COG5001	Diguanylate cyclase
C2U30_00860	COG0564	pseudouridine synthase activity
C2U30_00875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U30_00885	COG0625	glutathione transferase activity
C2U30_00900	COG0367	asparagine synthase
C2U30_00910	COG0647	UMP catabolic process
C2U30_00915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U30_00925	COG1902	pentaerythritol trinitrate reductase activity
C2U30_00930	COG1253	flavin adenine dinucleotide binding
C2U30_00945	COG0277	FAD linked oxidase domain protein
C2U30_00945	COG0247	lactate metabolic process
C2U30_00955	COG2050	protein possibly involved in aromatic compounds catabolism
C2U30_00975	COG0583	DNA-binding transcription factor activity
C2U30_00980	COG2814	Major facilitator Superfamily
C2U30_00985	COG2056	Na+-H+ antiporter family
C2U30_00990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U30_01005	COG0483	inositol monophosphate 1-phosphatase activity
C2U30_01015	COG0625	glutathione transferase activity
C2U30_01020	COG0625	glutathione transferase activity
C2U30_01030	COG0601	transmembrane transport
C2U30_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U30_01040	COG0444	Belongs to the ABC transporter superfamily
C2U30_01045	COG2814	Major facilitator Superfamily
C2U30_01065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U30_01070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U30_01075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U30_01080	COG0509	glycine decarboxylation via glycine cleavage system
C2U30_01085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U30_01085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U30_01105	COG2814	Major facilitator Superfamily
C2U30_01110	COG3634	alkyl hydroperoxide reductase activity
C2U30_01115	COG0450	alkyl hydroperoxide reductase
C2U30_01120	COG0517	IMP dehydrogenase activity
C2U30_01125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U30_01130	COG0343	queuine tRNA-ribosyltransferase activity
C2U30_01135	COG1862	Preprotein translocase
C2U30_01140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U30_01145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U30_01150	COG2897	thiosulfate sulfurtransferase activity
C2U30_01185	COG1104	cysteine desulfurase activity
C2U30_01190	COG0822	iron-sulfur transferase activity
C2U30_01200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U30_01205	COG0443	Heat shock 70 kDa protein
C2U30_01210	COG0633	Ferredoxin
C2U30_01220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U30_01225	COG0105	UTP biosynthetic process
C2U30_01230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U30_01240	COG1426	Protein conserved in bacteria
C2U30_01250	COG0124	histidyl-tRNA synthetase
C2U30_01255	COG2976	Protein conserved in bacteria
C2U30_01260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U30_01265	COG1160	GTP binding
C2U30_01270	COG1645	bacterial-type flagellum-dependent swarming motility
C2U30_01275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U30_01280	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U30_01280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U30_01285	COG1007	ATP synthesis coupled electron transport
C2U30_01290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U30_01300	COG0713	ATP synthesis coupled electron transport
C2U30_01305	COG0839	Belongs to the complex I subunit 6 family
C2U30_01310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U30_01315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U30_01320	COG1034	ATP synthesis coupled electron transport
C2U30_01335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U30_01335	COG0649	NAD binding
C2U30_01340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U30_01345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U30_01350	COG1360	Flagellar Motor Protein
C2U30_01355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U30_01370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U30_01380	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U30_01390	COG0724	RNA recognition motif
C2U30_01395	COG4989	oxidoreductase activity
C2U30_01420	COG0745	RESPONSE REGULATOR receiver
C2U30_01425	COG0583	DNA-binding transcription factor activity
C2U30_01435	COG3300	MHYT domain
C2U30_01435	COG5001	Diguanylate cyclase
C2U30_01440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U30_01480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U30_01485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U30_01490	COG0539	negative regulation of cytoplasmic translation
C2U30_01495	COG0776	regulation of translation
C2U30_01505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U30_01525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U30_01530	COG0602	queuosine metabolic process
C2U30_01535	COG3530	Putative quorum-sensing-regulated virulence factor
C2U30_01540	COG2096	Adenosyltransferase
C2U30_01545	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U30_01550	COG1757	Na H antiporter
C2U30_01555	COG1435	thymidine kinase activity
C2U30_01580	COG1737	Transcriptional regulator
C2U30_01585	COG1263	PTS System
C2U30_01585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_01585	COG2190	(PTS) system
C2U30_01590	COG2723	6-phospho-beta-galactosidase activity
C2U30_01605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U30_01625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U30_01640	COG2910	NAD(P)H-binding
C2U30_01645	COG0583	DNA-binding transcription factor activity
C2U30_01650	COG1917	Cupin 2, conserved barrel domain protein
C2U30_01650	COG4977	sequence-specific DNA binding
C2U30_01655	COG2200	EAL domain
C2U30_01660	COG3706	GGDEF domain
C2U30_01665	COG4774	siderophore transport
C2U30_01675	COG0583	DNA-binding transcription factor activity
C2U30_01680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U30_01690	COG0517	IMP dehydrogenase activity
C2U30_01690	COG0516	GMP reductase activity
C2U30_01705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U30_01710	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U30_01725	COG4235	cytochrome complex assembly
C2U30_01725	COG3088	subunit of a heme lyase
C2U30_01740	COG3301	Polysulphide reductase, NrfD
C2U30_01745	COG0437	4 iron, 4 sulfur cluster binding
C2U30_01750	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U30_01770	COG0247	lactate metabolic process
C2U30_01775	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U30_01780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U30_01785	COG3012	SEC-C Motif Domain Protein
C2U30_01790	COG0840	transmembrane signaling receptor activity
C2U30_01795	COG1940	carbohydrate kinase activity
C2U30_01795	COG1846	Transcriptional regulator
C2U30_01800	COG3290	protein histidine kinase activity
C2U30_01805	COG4565	transcriptional regulatory protein
C2U30_01820	COG3181	Tripartite tricarboxylate transporter family receptor
C2U30_01825	COG0739	heme binding
C2U30_01825	COG0741	lytic transglycosylase activity
C2U30_01825	COG1196	nuclear chromosome segregation
C2U30_01830	COG2985	domain, Protein
C2U30_01830	COG0569	domain protein
C2U30_01845	COG0556	nucleotide-excision repair
C2U30_01855	COG0586	Pfam SNARE associated Golgi protein
C2U30_01860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U30_01865	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U30_01870	COG2186	Transcriptional regulator
C2U30_01875	COG2719	SpoVR family
C2U30_01880	COG2718	Belongs to the UPF0229 family
C2U30_01885	COG2766	serine protein kinase
C2U30_01890	COG0514	ATP-dependent DNA helicase (RecQ)
C2U30_01895	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U30_01900	COG0814	amino acid
C2U30_01930	COG0058	SHG alpha-glucan phosphorylase activity
C2U30_01945	COG0471	metal ion transport
C2U30_01950	COG3118	belongs to the thioredoxin family
C2U30_01960	COG1132	(ABC) transporter
C2U30_01965	COG1132	(ABC) transporter
C2U30_01985	COG2501	S4 domain
C2U30_02005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U30_02010	COG2329	Antibiotic biosynthesis monooxygenase
C2U30_02045	COG0513	Belongs to the DEAD box helicase family
C2U30_02050	COG0386	Belongs to the glutathione peroxidase family
C2U30_02060	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U30_02070	COG0730	response to heat
C2U30_02075	COG0583	DNA-binding transcription factor activity
C2U30_02090	COG3593	DNA synthesis involved in DNA repair
C2U30_02130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U30_02135	COG1011	Hydrolase
C2U30_02140	COG1473	amidohydrolase
C2U30_02145	COG0205	6-phosphofructokinase activity
C2U30_02155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U30_02160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U30_02170	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U30_02175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U30_02180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U30_02205	COG0588	phosphoglycerate mutase activity
C2U30_02220	COG1280	lysine exporter protein (LysE YggA)
C2U30_02235	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U30_02270	COG2840	Smr protein MutS2
C2U30_02275	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U30_02280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U30_02290	COG0513	Belongs to the DEAD box helicase family
C2U30_02295	COG5654	RES domain protein
C2U30_02305	COG0814	amino acid
C2U30_02310	COG1609	Transcriptional regulator
C2U30_02315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_02315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_02320	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U30_02325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U30_02325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U30_02325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U30_02330	COG3313	Fe-S protein
C2U30_02335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U30_02340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U30_02345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U30_02350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U30_02360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U30_02390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U30_02395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U30_02400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U30_02405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U30_02410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U30_02415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U30_02415	COG0072	phenylalanine-tRNA ligase activity
C2U30_02420	COG0776	regulation of translation
C2U30_02440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U30_02450	COG2199	diguanylate cyclase activity
C2U30_02460	COG1609	Transcriptional regulator
C2U30_02465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U30_02470	COG1879	ABC-type sugar transport system periplasmic component
C2U30_02475	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U30_02480	COG1129	ABC transporter
C2U30_02485	COG1869	D-ribose catabolic process
C2U30_02490	COG0625	glutathione transferase activity
C2U30_02505	COG0037	tRNA processing
C2U30_02510	COG0589	response to stress
C2U30_02515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U30_02530	COG2217	Heavy metal translocating P-type atpase
C2U30_02540	COG2010	Cytochrome c
C2U30_02555	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U30_02565	COG1956	GAF domain-containing protein
C2U30_02570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U30_02580	COG0308	aminopeptidase N
C2U30_02590	COG2902	Dehydrogenase
C2U30_02595	COG0167	dihydroorotate dehydrogenase activity
C2U30_02605	COG0116	Belongs to the methyltransferase superfamily
C2U30_02605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U30_02630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U30_02635	COG1067	ATP-dependent peptidase activity
C2U30_02670	COG4128	Pfam Zonular occludens toxin
C2U30_02705	COG3141	response to X-ray
C2U30_02715	COG2995	paraquat-inducible protein a
C2U30_02720	COG3008	intermembrane lipid transfer
C2U30_02725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U30_02725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U30_02745	COG0697	spore germination
C2U30_02820	COG1695	Transcriptional regulator
C2U30_02830	COG3316	Transposase and inactivated derivatives
C2U30_02855	COG3173	Aminoglycoside phosphotransferase
C2U30_02865	COG3316	Transposase and inactivated derivatives
C2U30_02875	COG3316	Transposase and inactivated derivatives
C2U30_02895	COG3039	Transposase
C2U30_02915	COG0084	hydrolase, TatD family'
C2U30_02920	COG0470	DNA polymerase III
C2U30_02925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U30_02930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U30_02935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U30_02940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U30_02945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U30_02950	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_02960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U30_02965	COG0416	fatty acid biosynthetic process
C2U30_02970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U30_02975	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U30_02990	COG0564	pseudouridine synthase activity
C2U30_02995	COG1530	ribonuclease E activity
C2U30_03000	COG0306	phosphate transporter
C2U30_03005	COG0717	Belongs to the dCTP deaminase family
C2U30_03010	COG0572	uridine kinase
C2U30_03015	COG0489	protein tyrosine kinase activity
C2U30_03020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U30_03020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U30_03030	COG1254	Belongs to the acylphosphatase family
C2U30_03035	COG0840	transmembrane signaling receptor activity
C2U30_03040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U30_03055	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U30_03060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U30_03065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U30_03070	COG3437	response regulator, receiver
C2U30_03080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U30_03090	COG1643	Atp-dependent helicase
C2U30_03100	COG2197	response regulator
C2U30_03115	COG0583	DNA-binding transcription factor activity
C2U30_03120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U30_03130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U30_03135	COG2832	Protein of unknown function (DUF454)
C2U30_03140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U30_03150	COG0697	spore germination
C2U30_03165	COG0318	PFAM AMP-dependent synthetase and ligase
C2U30_03170	COG0596	Alpha beta hydrolase
C2U30_03180	COG1214	PFAM Peptidase M22, glycoprotease
C2U30_03185	COG1199	ATP-dependent helicase activity
C2U30_03195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U30_03200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U30_03205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U30_03210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U30_03210	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U30_03215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U30_03220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U30_03225	COG3437	response regulator, receiver
C2U30_03235	COG0784	Response regulator, receiver
C2U30_03235	COG2205	protein histidine kinase activity
C2U30_03235	COG2198	Histidine kinase
C2U30_03240	COG0107	imidazoleglycerol-phosphate synthase activity
C2U30_03245	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U30_03245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U30_03255	COG2378	regulation of single-species biofilm formation
C2U30_03260	COG0318	PFAM AMP-dependent synthetase and ligase
C2U30_03270	COG3134	Outer membrane lipoprotein
C2U30_03285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U30_03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U30_03315	COG4681	YaeQ
C2U30_03325	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U30_03325	COG1024	Enoyl-CoA hydratase
C2U30_03330	COG0183	Belongs to the thiolase family
C2U30_03335	COG0714	Associated with various cellular activities
C2U30_03365	COG1595	DNA-templated transcription, initiation
C2U30_03375	COG2067	long-chain fatty acid transport protein
C2U30_03380	COG2067	long-chain fatty acid transport protein
C2U30_03385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U30_03400	COG1301	dicarboxylic acid transport
C2U30_03405	COG3123	guanosine phosphorylase activity
C2U30_03410	COG1760	l-serine dehydratase
C2U30_03420	COG1760	l-serine dehydratase
C2U30_03430	COG2951	lytic endotransglycosylase activity
C2U30_03435	COG3100	YcgL domain-containing protein
C2U30_03440	COG0850	regulation of cytokinetic process
C2U30_03445	COG2894	cell division
C2U30_03450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U30_03460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U30_03480	COG2996	Protein conserved in bacteria
C2U30_03505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U30_03510	COG0697	spore germination
C2U30_03515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U30_03520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U30_03535	COG0307	riboflavin synthase, alpha
C2U30_03545	COG0534	Mate efflux family protein
C2U30_03575	COG0417	DNA replication proofreading
C2U30_03590	COG1560	Kdo2-lipid A biosynthetic process
C2U30_03595	COG1560	Kdo2-lipid A biosynthetic process
C2U30_03605	COG0583	DNA-binding transcription factor activity
C2U30_03610	COG0673	inositol 2-dehydrogenase activity
C2U30_03615	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U30_03630	COG0583	DNA-binding transcription factor activity
C2U30_03640	COG2723	6-phospho-beta-galactosidase activity
C2U30_03645	COG0583	DNA-binding transcription factor activity
C2U30_03650	COG0745	RESPONSE REGULATOR receiver
C2U30_03650	COG3706	GGDEF domain
C2U30_03655	COG0243	molybdopterin cofactor binding
C2U30_03660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U30_03675	COG0583	DNA-binding transcription factor activity
C2U30_03680	COG1879	ABC-type sugar transport system periplasmic component
C2U30_03685	COG1129	ABC transporter
C2U30_03690	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U30_03695	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U30_03745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U30_03780	COG0730	response to heat
C2U30_03790	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_03800	COG1024	Enoyl-CoA hydratase
C2U30_03805	COG1024	Enoyl-CoA hydratase
C2U30_03810	COG1960	acyl-CoA dehydrogenase activity
C2U30_03820	COG1960	acyl-CoA dehydrogenase activity
C2U30_03825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U30_03830	COG1024	Enoyl-CoA hydratase
C2U30_03855	COG1584	GPR1 FUN34 yaaH family protein
C2U30_03860	COG3228	Belongs to the MtfA family
C2U30_03870	COG1115	amino acid carrier protein
C2U30_03875	COG1024	Enoyl-CoA hydratase
C2U30_03890	COG3162	membrane
C2U30_03895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U30_03900	COG0488	(ABC) transporter
C2U30_03905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U30_03910	COG0776	regulation of translation
C2U30_03915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U30_03920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U30_03925	COG0740	serine-type endopeptidase activity
C2U30_03930	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U30_03945	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U30_03950	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U30_03955	COG1136	(ABC) transporter
C2U30_03960	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U30_03970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U30_03975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U30_03985	COG0697	spore germination
C2U30_03995	COG2062	phosphohistidine phosphatase, SixA
C2U30_04005	COG0500	methyltransferase
C2U30_04015	COG1846	Transcriptional regulator
C2U30_04060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U30_04060	COG0519	Catalyzes the synthesis of GMP from XMP
C2U30_04065	COG0517	IMP dehydrogenase activity
C2U30_04065	COG0516	GMP reductase activity
C2U30_04075	COG1874	Beta-galactosidase
C2U30_04075	COG0366	Alpha amylase catalytic
C2U30_04085	COG1570	exodeoxyribonuclease VII activity
C2U30_04095	COG2885	chlorophyll binding
C2U30_04115	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U30_04125	COG3768	UPF0283 membrane protein
C2U30_04130	COG3106	COG3106 Predicted ATPase
C2U30_04145	COG1842	Phage shock protein A
C2U30_04150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U30_04160	COG4168	peptide transport system, permease
C2U30_04165	COG4171	peptide transport system, permease
C2U30_04175	COG4172	Belongs to the ABC transporter superfamily
C2U30_04185	COG1609	Transcriptional regulator
C2U30_04190	COG1263	PTS System
C2U30_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_04195	COG2723	6-phospho-beta-galactosidase activity
C2U30_04200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U30_04205	COG1286	toxin biosynthetic process
C2U30_04210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U30_04215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U30_04220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U30_04225	COG1674	ftsk spoiiie
C2U30_04225	COG0531	amino acid
C2U30_04235	COG0686	Belongs to the AlaDH PNT family
C2U30_04240	COG0492	ferredoxin-NADP+ reductase activity
C2U30_04245	COG3706	GGDEF domain
C2U30_04250	COG3134	Outer membrane lipoprotein
C2U30_04255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U30_04260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U30_04265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U30_04270	COG0542	response to heat
C2U30_04275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U30_04280	COG1278	Cold shock
C2U30_04285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U30_04290	COG2076	Multidrug Resistance protein
C2U30_04305	COG1944	ATP diphosphatase activity
C2U30_04310	COG2116	formate transmembrane transporter activity
C2U30_04315	COG1882	Formate acetyltransferase
C2U30_04320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U30_04330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U30_04340	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U30_04345	COG3842	ATPase activity
C2U30_04355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U30_04365	COG3039	Transposase
C2U30_04380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U30_04385	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U30_04390	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U30_04395	COG0567	Dehydrogenase, E1 component
C2U30_04410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U30_04415	COG2009	succinate dehydrogenase
C2U30_04435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U30_04440	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U30_04440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U30_04450	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U30_04465	COG1451	nucleotide metabolic process
C2U30_04480	COG0254	rRNA binding
C2U30_04485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U30_04495	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U30_04505	COG1879	ABC-type sugar transport system periplasmic component
C2U30_04510	COG1069	ribulokinase activity
C2U30_04520	COG2160	L-arabinose isomerase activity
C2U30_04530	COG0436	Aminotransferase
C2U30_04535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U30_04550	COG0392	lysyltransferase activity
C2U30_04550	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2U30_04555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U30_04560	COG2925	Exonuclease
C2U30_04570	COG3345	alpha-galactosidase
C2U30_04575	COG1380	Effector of murein hydrolase LrgA
C2U30_04580	COG1346	cytolysis
C2U30_04585	COG0295	cytidine deaminase activity
C2U30_04590	COG1022	Amp-dependent synthetase and ligase
C2U30_04605	COG0861	Integral membrane protein TerC family
C2U30_04610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U30_04615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U30_04620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U30_04640	COG0598	Magnesium transport protein CorA
C2U30_04660	COG4771	TonB-dependent receptor
C2U30_04665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U30_04670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U30_04675	COG1120	ATPase activity
C2U30_04690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U30_04700	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_04705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U30_04710	COG3433	isochorismatase activity
C2U30_04710	COG1535	isochorismatase
C2U30_04715	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U30_04740	COG5001	Diguanylate cyclase
C2U30_04740	COG3300	MHYT domain
C2U30_04755	COG0840	transmembrane signaling receptor activity
C2U30_04760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U30_04765	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U30_04770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U30_04775	COG0563	adenylate kinase activity
C2U30_04785	COG0326	Molecular chaperone. Has ATPase activity
C2U30_04790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U30_04795	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2U30_04800	COG0298	carbon dioxide binding
C2U30_04810	COG0309	Hydrogenase expression formation protein (HypE)
C2U30_04815	COG0375	protein maturation
C2U30_04820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2U30_04825	COG1124	(ABC) transporter
C2U30_04830	COG0444	Belongs to the ABC transporter superfamily
C2U30_04835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U30_04860	COG1773	rubredoxin
C2U30_04865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U30_04870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2U30_04875	COG5557	Pfam Polysulphide reductase, NrfD
C2U30_04880	COG0437	4 iron, 4 sulfur cluster binding
C2U30_04885	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2U30_04890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U30_04900	COG2801	Transposase and inactivated derivatives
C2U30_04910	COG0659	secondary active sulfate transmembrane transporter activity
C2U30_04930	COG2308	Evidence 4 Homologs of previously reported genes of
C2U30_04965	COG0672	)-iron permease
C2U30_04990	COG2814	Major facilitator Superfamily
C2U30_05010	COG1136	(ABC) transporter
C2U30_05045	COG1139	Iron-sulfur cluster binding protein
C2U30_05050	COG0247	lactate metabolic process
C2U30_05055	COG1620	l-lactate permease
C2U30_05060	COG0583	DNA-binding transcription factor activity
C2U30_05085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U30_05090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U30_05090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U30_05095	COG0527	aspartate kinase activity
C2U30_05105	COG1368	sulfuric ester hydrolase activity
C2U30_05110	COG0393	Putative heavy-metal-binding
C2U30_05115	COG1252	NADH dehydrogenase
C2U30_05125	COG1164	Oligoendopeptidase f
C2U30_05130	COG1164	Oligoendopeptidase f
C2U30_05135	COG2354	Protein conserved in bacteria
C2U30_05150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U30_05155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U30_05190	COG0537	adenosine 5'-monophosphoramidase activity
C2U30_05205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U30_05220	COG1301	dicarboxylic acid transport
C2U30_05230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U30_05235	COG0861	Integral membrane protein TerC family
C2U30_05245	COG0444	Belongs to the ABC transporter superfamily
C2U30_05250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U30_05255	COG0601	transmembrane transport
C2U30_05265	COG2095	MarC family integral membrane protein
C2U30_05270	COG1454	alcohol dehydrogenase
C2U30_05270	COG1012	belongs to the aldehyde dehydrogenase family
C2U30_05280	COG3275	phosphorelay sensor kinase activity
C2U30_05285	COG3279	Response regulator of the LytR AlgR family
C2U30_05290	COG1966	Carbon starvation protein
C2U30_05295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U30_05295	COG3264	Mechanosensitive ion channel
C2U30_05305	COG1566	PFAM secretion protein HlyD family protein
C2U30_05310	COG1061	Type III restriction enzyme res subunit
C2U30_05315	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U30_05320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U30_05330	COG0436	Aminotransferase
C2U30_05335	COG1288	antiporter activity
C2U30_05340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U30_05360	COG0697	spore germination
C2U30_05365	COG4657	Part of a membrane complex involved in electron transport
C2U30_05370	COG2878	Part of a membrane complex involved in electron transport
C2U30_05380	COG4658	electron transport chain
C2U30_05385	COG4659	FMN binding
C2U30_05395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U30_05400	COG0346	lactoylglutathione lyase activity
C2U30_05420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U30_05430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U30_05445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U30_05450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U30_05455	COG2089	acid synthase
C2U30_05470	COG0673	inositol 2-dehydrogenase activity
C2U30_05475	COG1083	cytidylyl-transferase
C2U30_05480	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_05505	COG1334	flagellar protein FlaG
C2U30_05510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U30_05515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U30_05520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U30_05545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U30_05545	COG0301	tRNA thio-modification
C2U30_05555	COG4953	penicillin-binding protein 1C
C2U30_05560	COG2373	Large extracellular alpha-helical protein
C2U30_05565	COG0628	permease
C2U30_05575	COG1566	PFAM secretion protein HlyD family protein
C2U30_05590	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U30_05600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U30_05610	COG4160	amino acid transport
C2U30_05615	COG4215	(ABC) transporter
C2U30_05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_05630	COG2431	L-lysine efflux transmembrane transporter activity
C2U30_05635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U30_05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_05665	COG1393	Belongs to the ArsC family
C2U30_05675	COG4783	chaperone-mediated protein folding
C2U30_05680	COG0425	Belongs to the sulfur carrier protein TusA family
C2U30_05710	COG3842	ATPase activity
C2U30_05720	COG1175	transmembrane transport
C2U30_05730	COG3081	Nucleoid-associated protein
C2U30_05735	COG3082	Protein of unknown function (DUF1414)
C2U30_05740	COG3083	sulfuric ester hydrolase activity
C2U30_05750	COG1770	oligopeptidase
C2U30_05770	COG4574	serine-type endopeptidase inhibitor activity
C2U30_05775	COG3085	chromosome segregation
C2U30_05785	COG0287	Prephenate dehydrogenase
C2U30_05785	COG1605	Chorismate mutase
C2U30_05790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U30_05795	COG0584	glycerophosphoryl diester phosphodiesterase
C2U30_05810	COG1349	DNA-binding transcription factor activity
C2U30_05815	COG2271	Major facilitator Superfamily
C2U30_05820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U30_05825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U30_05830	COG0583	DNA-binding transcription factor activity
C2U30_05855	COG2814	Major facilitator Superfamily
C2U30_05865	COG1294	oxidase, subunit
C2U30_05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U30_05885	COG2979	Protein of unknown function (DUF533)
C2U30_05905	COG0583	DNA-binding transcription factor activity
C2U30_05915	COG2807	transmembrane transport
C2U30_05920	COG1187	pseudouridine synthase activity
C2U30_05925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U30_05945	COG1061	Type III restriction enzyme res subunit
C2U30_05970	COG1166	arginine decarboxylase activity
C2U30_05985	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U30_06015	COG0583	DNA-binding transcription factor activity
C2U30_06025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U30_06030	COG0840	transmembrane signaling receptor activity
C2U30_06035	COG0840	transmembrane signaling receptor activity
C2U30_06040	COG0302	gtp cyclohydrolase
C2U30_06050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U30_06060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U30_06075	COG0314	molybdopterin synthase activity
C2U30_06080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U30_06085	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U30_06090	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U30_06095	COG3005	denitrification pathway
C2U30_06105	COG0348	domain, Protein
C2U30_06110	COG0437	4 iron, 4 sulfur cluster binding
C2U30_06115	COG0243	molybdopterin cofactor binding
C2U30_06125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U30_06125	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U30_06130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U30_06135	COG3850	Histidine kinase
C2U30_06140	COG2197	response regulator
C2U30_06155	COG2205	protein histidine kinase activity
C2U30_06155	COG0784	Response regulator, receiver
C2U30_06165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U30_06175	COG0121	glutamine amidotransferase
C2U30_06180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U30_06185	COG1960	acyl-CoA dehydrogenase activity
C2U30_06190	COG0784	Response regulator, receiver
C2U30_06190	COG3437	response regulator, receiver
C2U30_06200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U30_06205	COG0328	RNA-DNA hybrid ribonuclease activity
C2U30_06210	COG2226	methyltransferase
C2U30_06215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U30_06220	COG0741	lytic transglycosylase activity
C2U30_06220	COG1388	LysM domain
C2U30_06225	COG3021	interspecies interaction between organisms
C2U30_06235	COG1607	acyl-coa hydrolase
C2U30_06250	COG0741	lytic transglycosylase activity
C2U30_06260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U30_06275	COG2911	Protein conserved in bacteria
C2U30_06280	COG0729	surface antigen
C2U30_06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U30_06300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U30_06310	COG4134	Bacterial extracellular solute-binding protein
C2U30_06320	COG4136	ATPase activity
C2U30_06325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U30_06330	COG2951	lytic endotransglycosylase activity
C2U30_06335	COG1846	Transcriptional regulator
C2U30_06345	COG0033	Phosphoglucomutase
C2U30_06350	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U30_06355	COG0596	Alpha beta hydrolase
C2U30_06370	COG0716	FMN binding
C2U30_06380	COG0735	belongs to the Fur family
C2U30_06385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_06395	COG2190	(PTS) system
C2U30_06395	COG1263	PTS System
C2U30_06395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_06400	COG0363	glucosamine-6-phosphate deaminase activity
C2U30_06405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U30_06410	COG1846	Transcriptional regulator
C2U30_06410	COG1940	carbohydrate kinase activity
C2U30_06415	COG2194	sulfuric ester hydrolase activity
C2U30_06425	COG0217	transcriptional regulatory protein
C2U30_06430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U30_06440	COG1801	Protein of unknown function DUF72
C2U30_06445	COG4106	trans-aconitate 2-methyltransferase activity
C2U30_06450	COG0500	methyltransferase
C2U30_06470	COG0583	DNA-binding transcription factor activity
C2U30_06475	COG0791	NLP P60 protein
C2U30_06490	COG1309	transcriptional regulator
C2U30_06525	COG0534	Mate efflux family protein
C2U30_06535	COG2841	Protein conserved in bacteria
C2U30_06540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U30_06540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U30_06540	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U30_06540	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U30_06550	COG3217	Mosc domain protein beta barrel domain protein
C2U30_06550	COG0633	Ferredoxin
C2U30_06550	COG0633	Ferredoxin
C2U30_06550	COG3217	Mosc domain protein beta barrel domain protein
C2U30_06555	COG0501	Belongs to the peptidase M48B family
C2U30_06560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U30_06565	COG2226	methyltransferase
C2U30_06565	COG1073	alpha beta
C2U30_06570	COG0156	8-amino-7-oxononanoate synthase activity
C2U30_06575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U30_06595	COG0017	Asparaginyl-tRNA synthetase
C2U30_06600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U30_06610	COG1473	amidohydrolase
C2U30_06615	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U30_06625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U30_06635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U30_06640	COG1393	Belongs to the ArsC family
C2U30_06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U30_06650	COG1876	peptidase activity
C2U30_06660	COG3263	regulation of cellular component size
C2U30_06670	COG1280	lysine exporter protein (LysE YggA)
C2U30_06695	COG1957	nucleoside hydrolase
C2U30_06700	COG0564	pseudouridine synthase activity
C2U30_06705	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U30_06710	COG1454	alcohol dehydrogenase
C2U30_06715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U30_06720	COG0702	epimerase
C2U30_06730	COG2867	negative regulation of translational initiation
C2U30_06735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U30_06805	COG4397	Mu-like prophage major head subunit gpT
C2U30_06810	COG4388	Caudovirus prohead serine protease
C2U30_06820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U30_06825	COG2194	sulfuric ester hydrolase activity
C2U30_06845	COG4383	Mu-like prophage protein gp29
C2U30_06850	COG4373	Mu-like prophage FluMu protein gp28
C2U30_06860	COG0640	Transcriptional regulator
C2U30_07010	COG2801	Transposase and inactivated derivatives
C2U30_07040	COG0246	Mannitol dehydrogenase
C2U30_07045	COG2721	sulfolactate sulfo-lyase activity
C2U30_07055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U30_07060	COG0800	Aldolase
C2U30_07075	COG3153	acetyltransferase
C2U30_07105	COG0259	pyridoxamine-phosphate oxidase activity
C2U30_07120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U30_07120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U30_07125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U30_07140	COG0457	Tetratricopeptide repeat
C2U30_07150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U30_07155	COG1138	Cytochrome C-type biogenesis protein
C2U30_07160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U30_07165	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U30_07170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U30_07175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U30_07190	COG0835	chemotaxis
C2U30_07200	COG1192	Involved in chromosome partitioning
C2U30_07205	COG1360	Flagellar Motor Protein
C2U30_07210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U30_07215	COG2201	protein-glutamate methylesterase activity
C2U30_07220	COG0643	Histidine kinase
C2U30_07220	COG2198	Histidine kinase
C2U30_07225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U30_07240	COG0455	bacterial-type flagellum organization
C2U30_07250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U30_07260	COG1684	flagellar biosynthetic protein fliR
C2U30_07265	COG1987	bacterial-type flagellum assembly
C2U30_07315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U30_07325	COG1677	Flagellar hook-basal body complex protein FliE
C2U30_07335	COG1393	Belongs to the ArsC family
C2U30_07340	COG0798	PFAM Bile acid sodium symporter
C2U30_07345	COG0640	Transcriptional regulator
C2U30_07355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U30_07370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U30_07375	COG0444	Belongs to the ABC transporter superfamily
C2U30_07380	COG4608	Belongs to the ABC transporter superfamily
C2U30_07390	COG2971	BadF BadG BcrA BcrD
C2U30_07400	COG0840	transmembrane signaling receptor activity
C2U30_07410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U30_07415	COG3724	N-succinylarginine dihydrolase activity
C2U30_07420	COG0616	signal peptide processing
C2U30_07425	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_07430	COG0583	DNA-binding transcription factor activity
C2U30_07440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U30_07450	COG0583	DNA-binding transcription factor activity
C2U30_07470	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2U30_07470	COG3408	Glycogen debranching enzyme
C2U30_07475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U30_07480	COG0739	heme binding
C2U30_07485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U30_07515	COG2801	Transposase and inactivated derivatives
C2U30_07525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U30_07535	COG3091	SprT-like family
C2U30_07545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U30_07550	COG0189	ligase activity
C2U30_07555	COG1678	Uncharacterized ACR, COG1678
C2U30_07560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U30_07580	COG1115	amino acid carrier protein
C2U30_07585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U30_07600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U30_07610	COG1301	dicarboxylic acid transport
C2U30_07620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U30_07625	COG2912	Transglutaminase-like superfamily
C2U30_07635	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U30_07640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U30_07645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U30_07650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U30_07655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U30_07665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U30_07670	COG0193	aminoacyl-tRNA hydrolase activity
C2U30_07675	COG0012	GTP binding
C2U30_07680	COG0582	viral genome integration into host DNA
C2U30_07730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U30_07745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U30_07750	COG1196	nuclear chromosome segregation
C2U30_07760	COG0732	type I restriction modification DNA specificity domain
C2U30_07815	COG0490	domain, Protein
C2U30_07815	COG0471	metal ion transport
C2U30_07840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U30_07855	COG1012	belongs to the aldehyde dehydrogenase family
C2U30_07865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U30_07880	COG0180	Tryptophanyl-tRNA synthetase
C2U30_07885	COG0546	phosphoglycolate phosphatase activity
C2U30_07890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U30_07895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U30_07905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U30_07910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U30_07940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U30_07945	COG0583	DNA-binding transcription factor activity
C2U30_07960	COG0583	DNA-binding transcription factor activity
C2U30_07975	COG0739	heme binding
C2U30_07985	COG3264	Mechanosensitive ion channel
C2U30_07985	COG1511	domain protein
C2U30_07990	COG0584	glycerophosphoryl diester phosphodiesterase
C2U30_08000	COG1053	succinate dehydrogenase
C2U30_08005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U30_08010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U30_08015	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U30_08030	COG3214	Protein conserved in bacteria
C2U30_08035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U30_08055	COG0300	oxidoreductase activity
C2U30_08065	COG0745	RESPONSE REGULATOR receiver
C2U30_08075	COG0189	ligase activity
C2U30_08075	COG4067	protein conserved in archaea
C2U30_08080	COG0516	GMP reductase activity
C2U30_08090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U30_08095	COG2011	ABC-type metal ion transport system permease component
C2U30_08100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U30_08105	COG1464	Belongs to the NlpA lipoprotein family
C2U30_08120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U30_08130	COG2199	diguanylate cyclase activity
C2U30_08140	COG2199	diguanylate cyclase activity
C2U30_08145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U30_08160	COG1278	Cold shock
C2U30_08165	COG1335	isochorismatase
C2U30_08170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U30_08175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U30_08180	COG1702	phosphate starvation-inducible protein PhoH
C2U30_08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U30_08190	COG4535	Mg2 and Co2 transporter CorC
C2U30_08195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U30_08200	COG2888	peptidyl-tyrosine sulfation
C2U30_08205	COG0495	leucyl-tRNA aminoacylation
C2U30_08230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U30_08235	COG0799	negative regulation of ribosome biogenesis
C2U30_08240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U30_08245	COG0768	penicillin binding
C2U30_08250	COG0772	Belongs to the SEDS family
C2U30_08255	COG2951	lytic endotransglycosylase activity
C2U30_08260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U30_08265	COG1686	Belongs to the peptidase S11 family
C2U30_08270	COG2921	Belongs to the UPF0250 family
C2U30_08275	COG0321	lipoyl(octanoyl) transferase activity
C2U30_08285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U30_08300	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U30_08315	COG0789	Transcriptional regulator
C2U30_08330	COG1970	mechanosensitive ion channel activity
C2U30_08335	COG4974	Belongs to the 'phage' integrase family
C2U30_08340	COG0716	FMN binding
C2U30_08345	COG0312	modulator of DNA gyrase
C2U30_08350	COG0312	modulator of DNA gyrase
C2U30_08370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U30_08385	COG1422	Protein of unknown function (DUF1090)
C2U30_08390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U30_08395	COG2211	Major facilitator Superfamily
C2U30_08400	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U30_08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U30_08410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U30_08415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U30_08420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U30_08425	COG0195	Participates in both transcription termination and antitermination
C2U30_08430	COG0779	Required for maturation of 30S ribosomal subunits
C2U30_08445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U30_08450	COG0149	triose-phosphate isomerase activity
C2U30_08455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U30_08460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U30_08465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U30_08470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U30_08475	COG1534	Rna-binding protein
C2U30_08485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U30_08490	COG1360	Flagellar Motor Protein
C2U30_08495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U30_08500	COG1722	exodeoxyribonuclease VII activity
C2U30_08505	COG0142	geranyltranstransferase activity
C2U30_08510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U30_08530	COG4172	Belongs to the ABC transporter superfamily
C2U30_08535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U30_08540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U30_08545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U30_08550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U30_08565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U30_08565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U30_08570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U30_08580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U30_08595	COG3381	protein complex oligomerization
C2U30_08610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U30_08615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U30_08620	COG0511	ligase activity, forming carbon-carbon bonds
C2U30_08625	COG0439	Biotin carboxylase
C2U30_08630	COG3924	membrane
C2U30_08635	COG4145	pantothenate transmembrane transporter activity
C2U30_08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_08640	COG2190	(PTS) system
C2U30_08640	COG1263	PTS System
C2U30_08645	COG0583	DNA-binding transcription factor activity
C2U30_08650	COG0604	alcohol dehydrogenase
C2U30_08655	COG2264	protein methyltransferase activity
C2U30_08660	COG0110	maltose O-acetyltransferase activity
C2U30_08675	COG0778	Nitroreductase
C2U30_08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U30_08680	COG1902	pentaerythritol trinitrate reductase activity
C2U30_08685	COG0616	signal peptide processing
C2U30_08705	COG3139	Protein of unknown function (DUF1315)
C2U30_08710	COG0252	asparaginase activity
C2U30_08715	COG0786	glutamate:sodium symporter activity
C2U30_08730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U30_08740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U30_08745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U30_08750	COG0175	sulfate reduction
C2U30_08755	COG2113	Glycine betaine
C2U30_08760	COG4176	ABC-type proline glycine betaine transport system permease component
C2U30_08765	COG4175	Glycine betaine
C2U30_08775	COG3610	response to peptide
C2U30_08780	COG2966	Psort location CytoplasmicMembrane, score
C2U30_08790	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U30_08815	COG2313	pseudouridylate synthase activity
C2U30_08820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U30_08825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U30_08825	COG2146	nitrite reductase [NAD(P)H] activity
C2U30_08830	COG2146	nitrite reductase [NAD(P)H] activity
C2U30_08830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U30_08835	COG1116	anion transmembrane transporter activity
C2U30_08840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U30_08845	COG1116	anion transmembrane transporter activity
C2U30_08845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U30_08855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U30_08855	COG1648	precorrin-2 dehydrogenase activity
C2U30_08860	COG0243	molybdopterin cofactor binding
C2U30_08885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U30_08905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U30_08915	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U30_08925	COG4608	Belongs to the ABC transporter superfamily
C2U30_08930	COG0444	Belongs to the ABC transporter superfamily
C2U30_08940	COG4239	(ABC) transporter, permease
C2U30_08945	COG4174	ABC transporter (Permease)
C2U30_08950	COG4206	TonB-dependent receptor
C2U30_08960	COG0811	peptide transport
C2U30_08965	COG0811	peptide transport
C2U30_08970	COG0848	biopolymer transport protein
C2U30_09030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_09035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_09040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_09045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_09050	COG0840	transmembrane signaling receptor activity
C2U30_09060	COG1278	Cold shock
C2U30_09105	COG1192	Involved in chromosome partitioning
C2U30_09140	COG0629	single-stranded DNA binding
C2U30_09145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U30_09160	COG0789	Transcriptional regulator
C2U30_09170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U30_09320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U30_09325	COG1569	PIN domain
C2U30_09330	COG3311	Transcriptional regulator
C2U30_09385	COG2003	Belongs to the UPF0758 family
C2U30_09465	COG2326	polyphosphate kinase activity
C2U30_09470	COG2217	Heavy metal translocating P-type atpase
C2U30_09485	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U30_09495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2U30_09500	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U30_09520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U30_09525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U30_09540	COG0300	oxidoreductase activity
C2U30_09545	COG1309	transcriptional regulator
C2U30_09550	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2U30_09555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U30_09560	COG0789	Transcriptional regulator
C2U30_09565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U30_09585	COG5002	protein histidine kinase activity
C2U30_09590	COG0745	RESPONSE REGULATOR receiver
C2U30_09595	COG2132	Multicopper oxidase
C2U30_09630	COG0583	DNA-binding transcription factor activity
C2U30_09655	COG0582	viral genome integration into host DNA
C2U30_09670	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U30_09675	COG1162	GTPase activity
C2U30_09680	COG0688	phosphatidylethanolamine metabolic process
C2U30_09685	COG4628	conserved protein (DUF2132)
C2U30_09705	COG3300	MHYT domain
C2U30_09705	COG5001	Diguanylate cyclase
C2U30_09715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U30_09740	COG1132	(ABC) transporter
C2U30_09750	COG2897	thiosulfate sulfurtransferase activity
C2U30_09755	COG2066	Belongs to the glutaminase family
C2U30_09760	COG3171	Protein conserved in bacteria
C2U30_09765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U30_09770	COG2234	aminopeptidase activity
C2U30_09770	COG4935	Belongs to the peptidase S8 family
C2U30_09775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U30_09780	COG2200	EAL domain
C2U30_09785	COG1090	epimerase
C2U30_09790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U30_09795	COG4181	ATPase activity
C2U30_09800	COG2755	lipolytic protein G-D-S-L family
C2U30_09805	COG0835	chemotaxis
C2U30_09805	COG0784	Response regulator, receiver
C2U30_09815	COG0516	GMP reductase activity
C2U30_09815	COG0517	IMP dehydrogenase activity
C2U30_09820	COG0488	(ABC) transporter
C2U30_09830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U30_09885	COG0789	Transcriptional regulator
C2U30_09910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U30_09920	COG0668	transmembrane transport
C2U30_09930	COG2731	YhcH YjgK YiaL family protein
C2U30_09940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U30_09945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U30_09950	COG3227	Zinc metalloprotease (Elastase)
C2U30_09955	COG0583	DNA-binding transcription factor activity
C2U30_09960	COG0477	Major facilitator Superfamily
C2U30_09970	COG2985	domain, Protein
C2U30_09970	COG0569	domain protein
C2U30_09975	COG1272	protein, Hemolysin III
C2U30_09980	COG0076	glutamate decarboxylase activity
C2U30_09985	COG2917	probably involved in intracellular septation
C2U30_09990	COG2350	Protein conserved in bacteria
C2U30_10000	COG1555	photosystem II stabilization
C2U30_10005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U30_10010	COG3104	oligopeptide transport
C2U30_10015	COG0745	RESPONSE REGULATOR receiver
C2U30_10045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_10060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U30_10065	COG1280	lysine exporter protein (LysE YggA)
C2U30_10090	COG0316	Belongs to the HesB IscA family
C2U30_10100	COG0038	chloride channel
C2U30_10105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U30_10120	COG0671	phosphoesterase, PA-phosphatase related
C2U30_10130	COG0583	DNA-binding transcription factor activity
C2U30_10135	COG2076	Multidrug Resistance protein
C2U30_10145	COG0346	lactoylglutathione lyase activity
C2U30_10150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U30_10155	COG1643	Atp-dependent helicase
C2U30_10165	COG1489	DNA binding
C2U30_10170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U30_10175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U30_10185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U30_10190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U30_10195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U30_10205	COG0842	Transport permease protein
C2U30_10210	COG1131	(ABC) transporter
C2U30_10225	COG0163	prenyltransferase activity
C2U30_10230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U30_10235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U30_10250	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U30_10265	COG1136	(ABC) transporter
C2U30_10290	COG0840	transmembrane signaling receptor activity
C2U30_10320	COG0529	Catalyzes the synthesis of activated sulfate
C2U30_10325	COG3273	potassium ion transport
C2U30_10325	COG0471	metal ion transport
C2U30_10330	COG2895	sulfate adenylyltransferase (ATP) activity
C2U30_10335	COG0175	sulfate reduction
C2U30_10340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U30_10340	COG1648	precorrin-2 dehydrogenase activity
C2U30_10345	COG0330	HflC and HflK could
C2U30_10350	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U30_10360	COG0673	inositol 2-dehydrogenase activity
C2U30_10370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U30_10375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U30_10380	COG3036	rescue of stalled ribosome
C2U30_10395	COG0138	bifunctional purine biosynthesis protein purh
C2U30_10400	COG0151	Belongs to the GarS family
C2U30_10430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U30_10435	COG0358	DNA primase activity
C2U30_10440	COG1610	YqeY-like protein
C2U30_10445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U30_10450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U30_10460	COG4942	peptidase
C2U30_10460	COG1388	LysM domain
C2U30_10465	COG1238	metal cluster binding
C2U30_10470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U30_10475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U30_10480	COG0585	pseudouridine synthase activity
C2U30_10490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U30_10495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U30_10500	COG0148	phosphopyruvate hydratase activity
C2U30_10505	COG0504	CTP synthase activity
C2U30_10510	COG3956	TIGRFAM MazG family protein
C2U30_10515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U30_10520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U30_10530	COG4807	Protein conserved in bacteria
C2U30_10535	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U30_10540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U30_10545	COG1381	Involved in DNA repair and RecF pathway recombination
C2U30_10555	COG0571	ribonuclease III activity
C2U30_10560	COG0681	Belongs to the peptidase S26 family
C2U30_10565	COG0481	GTPase activity
C2U30_10580	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U30_10585	COG1595	DNA-templated transcription, initiation
C2U30_10590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U30_10600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U30_10605	COG0354	folic acid binding
C2U30_10610	COG0583	DNA-binding transcription factor activity
C2U30_10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U30_10660	COG0126	phosphoglycerate kinase activity
C2U30_10665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U30_10670	COG1940	carbohydrate kinase activity
C2U30_10675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U30_10680	COG2816	NAD+ diphosphatase activity
C2U30_10685	COG4991	sh3 domain protein
C2U30_10690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U30_10705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U30_10710	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_10725	COG1505	serine-type exopeptidase activity
C2U30_10730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U30_10735	COG0765	amino acid transport
C2U30_10740	COG0765	amino acid transport
C2U30_10745	COG1126	abc transporter atp-binding protein
C2U30_10750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_10755	COG3174	membrane
C2U30_10760	COG0110	maltose O-acetyltransferase activity
C2U30_10790	COG1942	4-Oxalocrotonate Tautomerase
C2U30_10800	COG0583	DNA-binding transcription factor activity
C2U30_10805	COG0165	Argininosuccinate lyase
C2U30_10810	COG0137	argininosuccinate synthase activity
C2U30_10820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U30_10825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U30_10835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U30_10840	COG5002	protein histidine kinase activity
C2U30_10840	COG5001	Diguanylate cyclase
C2U30_10840	COG3447	MASE1 domain protein
C2U30_10845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U30_10880	COG0583	DNA-binding transcription factor activity
C2U30_10885	COG1380	Effector of murein hydrolase LrgA
C2U30_10890	COG1346	cytolysis
C2U30_10895	COG0460	homoserine dehydrogenase
C2U30_10895	COG0527	aspartate kinase activity
C2U30_10900	COG0626	cystathionine gamma-synthase activity
C2U30_10915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U30_10920	COG0814	amino acid
C2U30_10925	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U30_10930	COG0494	nUDIX hydrolase
C2U30_10935	COG1011	Hydrolase
C2U30_10940	COG1902	pentaerythritol trinitrate reductase activity
C2U30_10950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U30_10965	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U30_10975	COG3156	type II secretion system protein K
C2U30_10985	COG4795	General secretion pathway protein
C2U30_10990	COG2165	general secretion pathway protein
C2U30_11000	COG2165	general secretion pathway protein
C2U30_11005	COG1459	type II secretion system
C2U30_11010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U30_11020	COG3031	protein transport across the cell outer membrane
C2U30_11030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U30_11035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U30_11050	COG0456	acetyltransferase
C2U30_11055	COG3133	Outer membrane lipoprotein
C2U30_11060	COG3025	triphosphatase activity
C2U30_11065	COG1392	Phosphate transport regulator
C2U30_11070	COG0306	phosphate transporter
C2U30_11075	COG0617	tRNA 3'-terminal CCA addition
C2U30_11080	COG3267	Type II secretory pathway component ExeA
C2U30_11080	COG3409	Peptidoglycan-binding domain 1 protein
C2U30_11090	COG1194	a g-specific adenine glycosylase
C2U30_11095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U30_11110	COG3240	lipase activity
C2U30_11120	COG3009	Protein conserved in bacteria
C2U30_11125	COG3008	intermembrane lipid transfer
C2U30_11125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U30_11130	COG2995	paraquat-inducible protein a
C2U30_11140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U30_11145	COG4251	negative regulation of phosphorylation
C2U30_11145	COG2203	Gaf domain
C2U30_11145	COG3706	GGDEF domain
C2U30_11145	COG5001	Diguanylate cyclase
C2U30_11150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U30_11155	COG2813	Specifically methylates the guanine in position
C2U30_11160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U30_11165	COG0297	glycogen (starch) synthase activity
C2U30_11205	COG1757	Na H antiporter
C2U30_11210	COG0583	DNA-binding transcription factor activity
C2U30_11215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U30_11220	COG3842	ATPase activity
C2U30_11225	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U30_11230	COG1177	transmembrane transport
C2U30_11240	COG0109	protoheme IX farnesyltransferase activity
C2U30_11270	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U30_11280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U30_11280	COG1565	acr, cog1565
C2U30_11285	COG1444	tRNA N-acetyltransferase activity
C2U30_11305	COG1803	Methylglyoxal synthase
C2U30_11320	COG0252	asparaginase activity
C2U30_11340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_11340	COG1263	PTS System
C2U30_11345	COG0366	Alpha amylase catalytic
C2U30_11350	COG0110	maltose O-acetyltransferase activity
C2U30_11355	COG1522	sequence-specific DNA binding
C2U30_11360	COG5006	permease, DMT superfamily
C2U30_11385	COG3068	Protein conserved in bacteria
C2U30_11395	COG0739	heme binding
C2U30_11415	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U30_11420	COG1121	(ABC) transporter
C2U30_11425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U30_11430	COG0583	DNA-binding transcription factor activity
C2U30_11440	COG1573	uracil-dna glycosylase
C2U30_11445	COG2962	Rard protein
C2U30_11450	COG2827	Endonuclease containing a URI domain
C2U30_11465	COG1842	Phage shock protein A
C2U30_11470	COG0204	Acyl-transferase
C2U30_11490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U30_11500	COG0484	heat shock protein binding
C2U30_11555	COG0187	DNA topoisomerase II activity
C2U30_11565	COG1566	PFAM secretion protein HlyD family protein
C2U30_11580	COG1051	belongs to the nudix hydrolase family
C2U30_11585	COG3150	esterase
C2U30_11595	COG3151	Protein conserved in bacteria
C2U30_11600	COG0494	nUDIX hydrolase
C2U30_11605	COG1538	Outer membrane efflux protein
C2U30_11610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U30_11610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U30_11615	COG1560	Kdo2-lipid A biosynthetic process
C2U30_11635	COG2771	luxR family
C2U30_11640	COG3916	Acyl-homoserine-lactone synthase
C2U30_11650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U30_11655	COG2213	PTS system mannitol-specific
C2U30_11655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_11660	COG0246	Mannitol dehydrogenase
C2U30_11665	COG3722	fumarate hydratase activity
C2U30_11670	COG3263	regulation of cellular component size
C2U30_11690	COG1671	Belongs to the UPF0178 family
C2U30_11705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U30_11710	COG0513	Belongs to the DEAD box helicase family
C2U30_11730	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U30_11735	COG1169	isochorismate synthase
C2U30_11740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U30_11745	COG0596	Alpha beta hydrolase
C2U30_11750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U30_11755	COG1441	menaquinone biosynthetic process
C2U30_11760	COG0318	PFAM AMP-dependent synthetase and ligase
C2U30_11765	COG3291	Pkd domain containing protein
C2U30_11770	COG2949	membrane
C2U30_11785	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U30_11815	COG2873	o-acetylhomoserine
C2U30_11825	COG1979	alcohol dehydrogenase
C2U30_11840	COG4221	oxidoreductase activity
C2U30_11860	COG1285	pathogenesis
C2U30_11875	COG1368	sulfuric ester hydrolase activity
C2U30_11880	COG1522	sequence-specific DNA binding
C2U30_11890	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U30_11900	COG1546	Belongs to the CinA family
C2U30_11900	COG1058	Belongs to the CinA family
C2U30_11905	COG1988	membrane-bound metal-dependent
C2U30_11915	COG0561	phosphatase activity
C2U30_11920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U30_11930	COG1011	Hydrolase
C2U30_11945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U30_11950	COG0019	diaminopimelate decarboxylase activity
C2U30_11960	COG1965	Belongs to the frataxin family
C2U30_11965	COG0400	carboxylic ester hydrolase activity
C2U30_11970	COG3072	Adenylate cyclase
C2U30_11975	COG0181	hydroxymethylbilane synthase activity
C2U30_11985	COG2959	enzyme of heme biosynthesis
C2U30_11990	COG3071	HemY protein
C2U30_11995	COG0312	modulator of DNA gyrase
C2U30_12000	COG3028	Belongs to the UPF0307 family
C2U30_12010	COG2926	Belongs to the UPF0265 family
C2U30_12040	COG1396	sequence-specific DNA binding
C2U30_12045	COG3135	benzoate transporter
C2U30_12075	COG3047	cAMP biosynthetic process
C2U30_12080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U30_12085	COG2197	response regulator
C2U30_12110	COG1278	Cold shock
C2U30_12115	COG2205	protein histidine kinase activity
C2U30_12120	COG0745	RESPONSE REGULATOR receiver
C2U30_12140	COG3706	GGDEF domain
C2U30_12145	COG0347	Belongs to the P(II) protein family
C2U30_12150	COG0004	ammonium transporteR
C2U30_12160	COG0346	lactoylglutathione lyase activity
C2U30_12170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U30_12175	COG1074	ATP-dependent DNA helicase activity
C2U30_12180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U30_12185	COG2259	Doxx family
C2U30_12190	COG1741	Belongs to the pirin family
C2U30_12200	COG0583	DNA-binding transcription factor activity
C2U30_12225	COG1175	transmembrane transport
C2U30_12235	COG3842	ATPase activity
C2U30_12245	COG3706	GGDEF domain
C2U30_12245	COG0745	RESPONSE REGULATOR receiver
C2U30_12265	COG0454	-acetyltransferase
C2U30_12265	COG0456	acetyltransferase
C2U30_12270	COG0753	catalase activity
C2U30_12290	COG0494	nUDIX hydrolase
C2U30_12305	COG2957	Belongs to the agmatine deiminase family
C2U30_12310	COG0583	DNA-binding transcription factor activity
C2U30_12325	COG1461	Dihydroxyacetone kinase
C2U30_12330	COG2376	Dihydroxyacetone kinase
C2U30_12370	COG3451	type IV secretory pathway VirB4
C2U30_12380	COG3838	Conjugal transfer protein Trbc
C2U30_12385	COG4962	Type ii secretion system protein e
C2U30_12405	COG0583	DNA-binding transcription factor activity
C2U30_12430	COG2076	Multidrug Resistance protein
C2U30_12455	COG4959	Type IV secretory pathway protease TraF
C2U30_12470	COG1192	Involved in chromosome partitioning
C2U30_12515	COG5489	Protein of unknown function (DUF736)
C2U30_12535	COG1475	DNA binding
C2U30_12555	COG2003	Belongs to the UPF0758 family
C2U30_12560	COG4804	nuclease activity
C2U30_12570	COG2252	PERMEase
C2U30_12575	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U30_12615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U30_12620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U30_12625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U30_12630	COG0049	tRNA binding
C2U30_12635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U30_12640	COG2168	tRNA wobble position uridine thiolation
C2U30_12650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U30_12660	COG2964	Protein conserved in bacteria
C2U30_12670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U30_12675	COG0085	RNA polymerase activity
C2U30_12680	COG0222	ribosome binding
C2U30_12685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U30_12690	COG0081	regulation of translation
C2U30_12695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U30_12700	COG0250	Participates in transcription elongation, termination and antitermination
C2U30_12705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U30_12715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U30_12740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U30_12745	COG0569	domain protein
C2U30_12750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U30_12755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U30_12760	COG3005	denitrification pathway
C2U30_12765	COG0243	molybdopterin cofactor binding
C2U30_12775	COG2205	protein histidine kinase activity
C2U30_12780	COG0745	RESPONSE REGULATOR receiver
C2U30_12800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U30_12815	COG2204	response regulator
C2U30_12825	COG2205	protein histidine kinase activity
C2U30_12845	COG0516	GMP reductase activity
C2U30_12845	COG0517	IMP dehydrogenase activity
C2U30_12855	COG1522	sequence-specific DNA binding
C2U30_12860	COG2502	aspartate--ammonia ligase
C2U30_12865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U30_12870	COG0542	response to heat
C2U30_12880	COG0564	pseudouridine synthase activity
C2U30_12885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U30_12890	COG3681	Belongs to the UPF0597 family
C2U30_12895	COG2964	Protein conserved in bacteria
C2U30_12900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U30_12905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U30_12910	COG1979	alcohol dehydrogenase
C2U30_12915	COG2207	Transcriptional regulator
C2U30_12920	COG3040	lipid binding
C2U30_12930	COG0840	transmembrane signaling receptor activity
C2U30_12940	COG0583	DNA-binding transcription factor activity
C2U30_12960	COG0540	Belongs to the ATCase OTCase family
C2U30_12965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U30_12970	COG1438	arginine binding
C2U30_12975	COG1288	antiporter activity
C2U30_12980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U30_13020	COG3250	beta-galactosidase activity
C2U30_13025	COG1609	Transcriptional regulator
C2U30_13030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U30_13040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U30_13045	COG2017	converts alpha-aldose to the beta-anomer
C2U30_13050	COG0667	Aldo Keto reductase
C2U30_13055	COG1968	undecaprenyl-diphosphatase activity
C2U30_13060	COG3806	Anti-sigma factor
C2U30_13065	COG1595	DNA-templated transcription, initiation
C2U30_13075	COG0018	arginyl-trna synthetase
C2U30_13085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U30_13090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U30_13110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_13115	COG1131	(ABC) transporter
C2U30_13120	COG0842	Transport permease protein
C2U30_13125	COG0842	Transport permease protein
C2U30_13130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U30_13135	COG2146	nitrite reductase [NAD(P)H] activity
C2U30_13140	COG2116	formate transmembrane transporter activity
C2U30_13145	COG1648	precorrin-2 dehydrogenase activity
C2U30_13145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U30_13150	COG2239	Acts as a magnesium transporter
C2U30_13155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U30_13160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U30_13170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U30_13180	COG0514	ATP-dependent DNA helicase (RecQ)
C2U30_13185	COG2050	protein possibly involved in aromatic compounds catabolism
C2U30_13200	COG2258	MOSC domain
C2U30_13205	COG1177	transmembrane transport
C2U30_13210	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U30_13215	COG3842	ATPase activity
C2U30_13235	COG0174	glutamine synthetase
C2U30_13240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U30_13255	COG3045	CreA protein
C2U30_13260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U30_13265	COG0443	Heat shock 70 kDa protein
C2U30_13280	COG0366	Alpha amylase catalytic
C2U30_13295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U30_13305	COG2205	protein histidine kinase activity
C2U30_13315	COG0281	malic enzyme
C2U30_13320	COG0702	epimerase
C2U30_13325	COG0254	rRNA binding
C2U30_13330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U30_13335	COG1309	transcriptional regulator
C2U30_13355	COG0129	dihydroxy-acid dehydratase activity
C2U30_13360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U30_13365	COG3978	acetolactate synthase activity
C2U30_13380	COG0606	chelatase, subunit chli
C2U30_13385	COG0204	Acyl-transferase
C2U30_13390	COG0204	Acyl-transferase
C2U30_13395	COG1683	Conserved Protein
C2U30_13405	COG1335	isochorismatase
C2U30_13415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U30_13420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U30_13430	COG3084	Protein conserved in bacteria
C2U30_13435	COG5001	Diguanylate cyclase
C2U30_13435	COG4251	negative regulation of phosphorylation
C2U30_13435	COG2203	Gaf domain
C2U30_13435	COG3706	GGDEF domain
C2U30_13450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U30_13455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U30_13460	COG1561	YicC-like family, N-terminal region
C2U30_13470	COG1519	Transferase
C2U30_13475	COG0859	PFAM glycosyl transferase family 9
C2U30_13480	COG0463	Glycosyl transferase, family 2
C2U30_13485	COG0859	PFAM glycosyl transferase family 9
C2U30_13490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U30_13495	COG2990	Protein conserved in bacteria
C2U30_13500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U30_13510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U30_13515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U30_13520	COG2003	Belongs to the UPF0758 family
C2U30_13525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U30_13530	COG0756	dUTP diphosphatase activity
C2U30_13535	COG1309	transcriptional regulator
C2U30_13555	COG0668	transmembrane transport
C2U30_13565	COG0166	Belongs to the GPI family
C2U30_13570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U30_13575	COG0583	DNA-binding transcription factor activity
C2U30_13585	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U30_13585	COG1042	CoA-binding domain protein
C2U30_13585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U30_13625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U30_13630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U30_13635	COG2223	nitrite transmembrane transporter activity
C2U30_13640	COG3279	Response regulator of the LytR AlgR family
C2U30_13645	COG3275	phosphorelay sensor kinase activity
C2U30_13655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_13655	COG2205	protein histidine kinase activity
C2U30_13675	COG3188	usher protein
C2U30_13690	COG1280	lysine exporter protein (LysE YggA)
C2U30_13695	COG2223	nitrite transmembrane transporter activity
C2U30_13700	COG2081	HI0933 family
C2U30_13705	COG1528	Iron-storage protein
C2U30_13710	COG3706	GGDEF domain
C2U30_13715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U30_13725	COG0589	response to stress
C2U30_13765	COG3642	lipopolysaccharide core region biosynthetic process
C2U30_13770	COG0859	PFAM glycosyl transferase family 9
C2U30_13785	COG1758	RNA polymerase activity
C2U30_13790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U30_13795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U30_13805	COG2267	carboxylic ester hydrolase activity
C2U30_13810	COG0561	phosphatase activity
C2U30_13840	COG1309	transcriptional regulator
C2U30_13845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_13850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_13855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_13855	COG4191	Histidine kinase
C2U30_13860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U30_13885	COG2205	protein histidine kinase activity
C2U30_13890	COG0745	RESPONSE REGULATOR receiver
C2U30_13895	COG2814	Major facilitator Superfamily
C2U30_13910	COG3977	Valine--pyruvate aminotransferase
C2U30_13915	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U30_13920	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U30_13925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U30_13930	COG2207	Transcriptional regulator
C2U30_13935	COG0187	DNA topoisomerase II activity
C2U30_13945	COG0592	DNA-directed DNA polymerase activity
C2U30_13950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U30_13970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U30_13975	COG0594	ribonuclease P activity
C2U30_13980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U30_13985	COG0706	membrane insertase activity
C2U30_13990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U30_13995	COG4974	Belongs to the 'phage' integrase family
C2U30_14030	COG4644	lycopene metabolic process
C2U30_14045	COG0840	transmembrane signaling receptor activity
C2U30_14065	COG0741	lytic transglycosylase activity
C2U30_14095	COG4962	Type ii secretion system protein e
C2U30_14110	COG3451	type IV secretory pathway VirB4
C2U30_14125	COG3846	protein secretion by the type IV secretion system
C2U30_14140	COG2948	multi-organism process
C2U30_14150	COG0583	DNA-binding transcription factor activity
C2U30_14155	COG1846	Transcriptional regulator
C2U30_14175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U30_14190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U30_14200	COG0583	DNA-binding transcription factor activity
C2U30_14210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U30_14215	COG0625	glutathione transferase activity
C2U30_14270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U30_14280	COG0183	Belongs to the thiolase family
C2U30_14300	COG0783	Belongs to the Dps family
C2U30_14305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U30_14320	COG1028	Short-chain dehydrogenase reductase Sdr
C2U30_14325	COG1309	transcriptional regulator
C2U30_14370	COG3385	transposase activity
C2U30_14390	COG4644	lycopene metabolic process
C2U30_14450	COG3041	Addiction module toxin RelE StbE family
C2U30_14455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U30_14475	COG3550	peptidyl-serine autophosphorylation
C2U30_14485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U30_14490	COG1120	ATPase activity
C2U30_14495	COG4615	Cyclic peptide transporter
C2U30_14500	COG4774	siderophore transport
C2U30_14505	COG0716	FMN binding
C2U30_14510	COG0445	tRNA wobble uridine modification
C2U30_14515	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U30_14520	COG1192	Involved in chromosome partitioning
C2U30_14525	COG1475	DNA binding
C2U30_14535	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U30_14545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U30_14550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U30_14555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U30_14560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U30_14565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U30_14570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U30_14575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U30_14580	COG4452	Inner membrane protein CreD
C2U30_14595	COG2205	protein histidine kinase activity
C2U30_14600	COG0745	RESPONSE REGULATOR receiver
C2U30_14605	COG1349	DNA-binding transcription factor activity
C2U30_14610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U30_14615	COG2771	luxR family
C2U30_14625	COG0811	peptide transport
C2U30_14630	COG0811	peptide transport
C2U30_14635	COG0848	biopolymer transport protein
C2U30_14640	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U30_14680	COG0402	S-adenosylhomocysteine deaminase activity
C2U30_14685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U30_14695	COG3165	ubiquinone biosynthetic process from chorismate
C2U30_14700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U30_14705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U30_14710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U30_14715	COG0805	protein transport
C2U30_14720	COG0084	hydrolase, TatD family'
C2U30_14740	COG0742	ribosomal rna small subunit methyltransferase
C2U30_14750	COG0248	Ppx GppA phosphatase
C2U30_14755	COG0513	Belongs to the DEAD box helicase family
C2U30_14760	COG3118	belongs to the thioredoxin family
C2U30_14765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U30_14775	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U30_14785	COG2960	long-chain fatty acid transporting porin activity
C2U30_14800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U30_14830	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U30_14840	COG1609	Transcriptional regulator
C2U30_14845	COG3604	Transcriptional regulator
C2U30_14850	COG0426	domain, Protein
C2U30_14850	COG1773	rubredoxin
C2U30_14855	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U30_14865	COG0348	domain, Protein
C2U30_14885	COG0814	amino acid
C2U30_14900	COG3706	GGDEF domain
C2U30_14900	COG5001	Diguanylate cyclase
C2U30_14900	COG4251	negative regulation of phosphorylation
C2U30_14900	COG2203	Gaf domain
C2U30_14905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U30_14915	COG2801	Transposase and inactivated derivatives
C2U30_14920	COG0751	glycine-tRNA ligase activity
C2U30_14925	COG0752	glycyl-tRNA synthetase alpha subunit
C2U30_14930	COG2818	Glycosylase
C2U30_14935	COG1335	isochorismatase
C2U30_14950	COG2885	chlorophyll binding
C2U30_14970	COG0251	oxidation-reduction process
C2U30_14975	COG0425	Belongs to the sulfur carrier protein TusA family
C2U30_14990	COG2205	protein histidine kinase activity
C2U30_14995	COG0745	RESPONSE REGULATOR receiver
C2U30_15000	COG0183	Belongs to the thiolase family
C2U30_15005	COG1024	Enoyl-CoA hydratase
C2U30_15005	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U30_15010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U30_15015	COG0006	proline dipeptidase activity
C2U30_15020	COG1739	Uncharacterized protein family UPF0029
C2U30_15025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U30_15030	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U30_15060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U30_15065	COG2166	iron-sulfur cluster assembly
C2U30_15070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U30_15090	COG1063	alcohol dehydrogenase
C2U30_15095	COG0156	8-amino-7-oxononanoate synthase activity
C2U30_15105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U30_15120	COG3306	glycosyltransferase involved in LPS biosynthesis
C2U30_15125	COG0859	PFAM glycosyl transferase family 9
C2U30_15150	COG1609	Transcriptional regulator
C2U30_15170	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U30_15175	COG3161	chorismate lyase activity
C2U30_15180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U30_15190	COG2937	Belongs to the GPAT DAPAT family
C2U30_15195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U30_15210	COG0534	Mate efflux family protein
C2U30_15215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U30_15220	COG2205	protein histidine kinase activity
C2U30_15225	COG0745	RESPONSE REGULATOR receiver
C2U30_15235	COG1045	serine acetyltransferase
C2U30_15245	COG3074	FtsZ-dependent cytokinesis
C2U30_15250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U30_15255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U30_15255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U30_15260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U30_15295	COG1609	Transcriptional regulator
C2U30_15300	COG3250	beta-galactosidase activity
C2U30_15305	COG2731	YhcH YjgK YiaL family protein
C2U30_15310	COG0531	amino acid
C2U30_15315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U30_15320	COG0531	amino acid
C2U30_15325	COG0385	Bile acid
C2U30_15330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U30_15355	COG0583	DNA-binding transcription factor activity
C2U30_15385	COG0210	DNA helicase
C2U30_15420	COG0583	DNA-binding transcription factor activity
C2U30_15435	COG1733	regulation of RNA biosynthetic process
C2U30_15475	COG1280	lysine exporter protein (LysE YggA)
C2U30_15485	COG2962	Rard protein
C2U30_15490	COG1012	belongs to the aldehyde dehydrogenase family
C2U30_15495	COG1396	sequence-specific DNA binding
C2U30_15510	COG0519	Catalyzes the synthesis of GMP from XMP
C2U30_15510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U30_15520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U30_15540	COG1322	Protein conserved in bacteria
C2U30_15545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U30_15550	COG0569	domain protein
C2U30_15555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U30_15555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U30_15560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U30_15565	COG0242	peptide deformylase activity
C2U30_15575	COG0758	DNA mediated transformation
C2U30_15580	COG2922	Belongs to the Smg family
C2U30_15585	COG0551	DNA topoisomerase type I activity
C2U30_15590	COG0009	L-threonylcarbamoyladenylate synthase
C2U30_15595	COG0408	coproporphyrinogen oxidase activity
C2U30_15600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U30_15610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U30_15620	COG3078	GTPase activator activity
C2U30_15630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U30_15635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U30_15645	COG3852	Histidine kinase
C2U30_15655	COG0174	glutamine synthetase
C2U30_15665	COG1295	ribonuclease BN
C2U30_15670	COG1490	D-aminoacyl-tRNA deacylase activity
C2U30_15680	COG0456	acetyltransferase
C2U30_15690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U30_15695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U30_15700	COG2610	gluconate transmembrane transporter activity
C2U30_15705	COG3265	gluconokinase activity
C2U30_15710	COG0129	dihydroxy-acid dehydratase activity
C2U30_15715	COG0800	Aldolase
C2U30_15730	COG1609	Transcriptional regulator
C2U30_15740	COG4942	peptidase
C2U30_15745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U30_15750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U30_15755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U30_15760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U30_15765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U30_15765	COG0316	Belongs to the HesB IscA family
C2U30_15770	COG1040	competence protein
C2U30_15775	COG0596	Alpha beta hydrolase
C2U30_15790	COG2183	response to ionizing radiation
C2U30_15800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U30_15805	COG0745	RESPONSE REGULATOR receiver
C2U30_15810	COG2205	protein histidine kinase activity
C2U30_15820	COG0051	transcription antitermination factor activity, RNA binding
C2U30_15825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U30_15830	COG0088	Forms part of the polypeptide exit tunnel
C2U30_15835	COG0089	rRNA binding
C2U30_15840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U30_15845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U30_15850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U30_15855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U30_15860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U30_15865	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U30_15870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U30_15875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U30_15880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U30_15885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U30_15890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U30_15895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U30_15900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U30_15905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U30_15910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U30_15915	COG1841	ribosomal large subunit assembly
C2U30_15920	COG0200	Binds to the 23S rRNA
C2U30_15925	COG0201	protein transport
C2U30_15930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U30_15935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U30_15940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U30_15945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U30_15950	COG0202	RNA polymerase activity
C2U30_15955	COG0203	ribosomal protein L17
C2U30_16025	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U30_16030	COG0583	DNA-binding transcription factor activity
C2U30_16035	COG4221	oxidoreductase activity
C2U30_16050	COG1770	oligopeptidase
C2U30_16070	COG3714	YhhN family
C2U30_16085	COG0583	DNA-binding transcription factor activity
C2U30_16095	COG1301	dicarboxylic acid transport
C2U30_16105	COG2095	MarC family integral membrane protein
C2U30_16115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U30_16125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U30_16130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U30_16160	COG0742	ribosomal rna small subunit methyltransferase
C2U30_16165	COG0552	protein localization to endoplasmic reticulum
C2U30_16170	COG2884	Cell division ATP-binding protein ftsE
C2U30_16175	COG2177	Part of the ABC transporter FtsEX involved in
C2U30_16185	COG0288	reversible hydration of carbon dioxide
C2U30_16190	COG2188	Transcriptional regulator
C2U30_16200	COG1228	amidohydrolase
C2U30_16205	COG0010	Belongs to the arginase family
C2U30_16210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U30_16215	COG2986	histidine ammonia-lyase
C2U30_16225	COG2200	EAL domain
C2U30_16285	COG1459	type II secretion system
C2U30_16330	COG1077	Cell shape determining protein MreB Mrl
C2U30_16335	COG1792	Involved in formation and maintenance of cell shape
C2U30_16340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U30_16345	COG0424	maF-like protein
C2U30_16350	COG1530	ribonuclease E activity
C2U30_16355	COG3164	Protein of unknown function
C2U30_16360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U30_16365	COG0312	modulator of DNA gyrase
C2U30_16380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U30_16385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_16385	COG1263	PTS System
C2U30_16390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2U30_16405	COG0477	Major facilitator Superfamily
C2U30_16415	COG3437	response regulator, receiver
C2U30_16420	COG0784	Response regulator, receiver
C2U30_16420	COG2205	protein histidine kinase activity
C2U30_16420	COG5002	protein histidine kinase activity
C2U30_16425	COG2172	sigma factor antagonist activity
C2U30_16430	COG1366	Belongs to the anti-sigma-factor antagonist family
C2U30_16440	COG3700	Belongs to the class B bacterial acid phosphatase family
C2U30_16445	COG2321	neutral zinc metallopeptidase
C2U30_16480	COG0189	ligase activity
C2U30_16490	COG0745	RESPONSE REGULATOR receiver
C2U30_16505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U30_16510	COG0352	thiamine-phosphate diphosphorylase activity
C2U30_16515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U30_16525	COG2022	thiamine diphosphate biosynthetic process
C2U30_16530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U30_16555	COG0110	maltose O-acetyltransferase activity
C2U30_16565	COG2203	Gaf domain
C2U30_16565	COG2199	diguanylate cyclase activity
C2U30_16570	COG3932	Exopolysaccharide synthesis, ExoD
C2U30_16585	COG1733	regulation of RNA biosynthetic process
C2U30_16610	COG2226	methyltransferase
C2U30_16620	COG1494	fructose-1,6-bisphosphatase
C2U30_16630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U30_16635	COG5007	Belongs to the BolA IbaG family
C2U30_16645	COG2854	intermembrane phospholipid transfer
C2U30_16650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U30_16655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U30_16660	COG1127	ABC transporter
C2U30_16665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U30_16665	COG0517	IMP dehydrogenase activity
C2U30_16670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U30_16680	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U30_16685	COG1137	ATPase activity
C2U30_16690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U30_16700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_16705	COG1660	Displays ATPase and GTPase activities
C2U30_16710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_16730	COG3964	amidohydrolase
C2U30_16760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U30_16765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U30_16775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U30_16780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U30_16785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U30_16790	COG0723	plastoquinol--plastocyanin reductase activity
C2U30_16795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U30_16800	COG2857	Cytochrome c1
C2U30_16805	COG0625	glutathione transferase activity
C2U30_16810	COG2969	positive regulation of protein catabolic process
C2U30_16815	COG2823	Periplasmic or secreted lipoprotein
C2U30_16820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U30_16825	COG0792	nuclease activity
C2U30_16830	COG3107	peptidoglycan biosynthetic process
C2U30_16835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U30_16845	COG2001	Belongs to the MraZ family
C2U30_16850	COG0275	rRNA processing
C2U30_16855	COG3116	cell division
C2U30_16860	COG0768	penicillin binding
C2U30_16865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U30_16870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U30_16875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U30_16880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U30_16885	COG0772	Belongs to the SEDS family
C2U30_16890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U30_16895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U30_16900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U30_16905	COG0849	cell division
C2U30_16910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U30_16915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U30_16925	COG0653	protein targeting
C2U30_16935	COG0494	nUDIX hydrolase
C2U30_16940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U30_16945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U30_16960	COG1459	type II secretion system
C2U30_16965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U30_17000	COG2186	Transcriptional regulator
C2U30_17005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U30_17010	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U30_17015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U30_17025	COG0840	transmembrane signaling receptor activity
C2U30_17030	COG0840	transmembrane signaling receptor activity
C2U30_17035	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U30_17040	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U30_17045	COG2200	EAL domain
C2U30_17055	COG1280	lysine exporter protein (LysE YggA)
C2U30_17065	COG0523	cobalamin synthesis protein
C2U30_17070	COG0477	Major facilitator Superfamily
C2U30_17085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U30_17090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U30_17135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U30_17145	COG1546	Belongs to the CinA family
C2U30_17150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U30_17155	COG2137	regulation of response to DNA damage stimulus
C2U30_17160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U30_17165	COG0527	aspartate kinase activity
C2U30_17170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U30_17205	COG1686	Belongs to the peptidase S11 family
C2U30_17210	COG0586	Pfam SNARE associated Golgi protein
C2U30_17215	COG1253	flavin adenine dinucleotide binding
C2U30_17220	COG0525	valine-tRNA ligase activity
C2U30_17225	COG2927	DNA polymerase III (CHI subunit)
C2U30_17230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U30_17235	COG0795	lipopolysaccharide-transporting ATPase activity
C2U30_17240	COG0795	lipopolysaccharide-transporting ATPase activity
C2U30_17255	COG0582	viral genome integration into host DNA
C2U30_17325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U30_17365	COG0004	ammonium transporteR
C2U30_17370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U30_17385	COG0084	hydrolase, TatD family'
C2U30_17390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U30_17400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U30_17405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U30_17410	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U30_17415	COG0813	purine-nucleoside phosphorylase activity
C2U30_17430	COG0560	Phosphoserine phosphatase
C2U30_17445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U30_17455	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U30_17460	COG0776	regulation of translation
C2U30_17475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U30_17480	COG0735	belongs to the Fur family
C2U30_17500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U30_17505	COG0513	Belongs to the DEAD box helicase family
C2U30_17510	COG3022	response to hydroperoxide
C2U30_17515	COG2805	Type II/IV secretion system protein
C2U30_17525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U30_17530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U30_17535	COG0762	integral membrane protein
C2U30_17540	COG1872	DUF167
C2U30_17565	COG3112	Uncharacterised protein family (UPF0231)
C2U30_17570	COG3835	regulator
C2U30_17575	COG2610	gluconate transmembrane transporter activity
C2U30_17580	COG1929	Belongs to the glycerate kinase type-1 family
C2U30_17595	COG0583	DNA-binding transcription factor activity
C2U30_17600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U30_17620	COG0347	Belongs to the P(II) protein family
C2U30_17635	COG3842	ATPase activity
C2U30_17640	COG2837	iron assimilation
C2U30_17645	COG1438	arginine binding
C2U30_17650	COG1126	abc transporter atp-binding protein
C2U30_17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_17660	COG4215	(ABC) transporter
C2U30_17665	COG4160	amino acid transport
C2U30_17670	COG0039	L-malate dehydrogenase activity
C2U30_17680	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U30_17685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U30_17685	COG1017	nitric oxide dioxygenase activity
C2U30_17695	COG4536	flavin adenine dinucleotide binding
C2U30_17700	COG4137	Cytochrome C assembly protein
C2U30_17705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U30_17715	COG0228	four-way junction DNA binding
C2U30_17720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U30_17725	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U30_17730	COG0335	large ribosomal subunit rRNA binding
C2U30_17740	COG3066	DNA modification
C2U30_17745	COG1051	belongs to the nudix hydrolase family
C2U30_17755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U30_17760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U30_17765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U30_17775	COG0583	DNA-binding transcription factor activity
C2U30_17780	COG0640	Transcriptional regulator
C2U30_17785	COG0268	Binds directly to 16S ribosomal RNA
C2U30_17790	COG0728	peptidoglycan biosynthetic process
C2U30_17795	COG0196	riboflavin kinase activity
C2U30_17800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U30_17805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U30_17810	COG1047	Peptidyl-prolyl cis-trans
C2U30_17815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U30_17820	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U30_17860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U30_17860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U30_17875	COG1854	S-ribosylhomocysteine lyase activity
C2U30_17880	COG3706	GGDEF domain
C2U30_17885	COG0557	exoribonuclease II activity
C2U30_17890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U30_17900	COG2153	protein acetylation
C2U30_17910	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U30_17915	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U30_17920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U30_17925	COG0359	binds to the 23S rRNA
C2U30_17965	COG1238	metal cluster binding
C2U30_17970	COG0612	Peptidase, M16
C2U30_17975	COG2918	glutathione biosynthetic process
C2U30_17980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U30_17985	COG1027	Aspartate ammonia-lyase
C2U30_17990	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U30_18000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U30_18005	COG0459	protein refolding
C2U30_18025	COG0564	pseudouridine synthase activity
C2U30_18030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U30_18060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U30_18070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U30_18075	COG4208	sulfate ABC transporter
C2U30_18080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U30_18085	COG0583	DNA-binding transcription factor activity
C2U30_18090	COG3397	chitin binding
C2U30_18095	COG0840	transmembrane signaling receptor activity
C2U30_18120	COG1328	CTP reductase activity
C2U30_18125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U30_18140	COG1448	Aminotransferase
C2U30_18145	COG2194	sulfuric ester hydrolase activity
C2U30_18165	COG1215	transferase activity, transferring glycosyl groups
C2U30_18175	COG0457	Tetratricopeptide repeat
C2U30_18175	COG3118	belongs to the thioredoxin family
C2U30_18180	COG0457	Tetratricopeptide repeat
C2U30_18180	COG3118	belongs to the thioredoxin family
C2U30_18215	COG0513	Belongs to the DEAD box helicase family
C2U30_18220	COG0840	transmembrane signaling receptor activity
C2U30_18230	COG4166	transmembrane transport
C2U30_18240	COG0110	maltose O-acetyltransferase activity
C2U30_18250	COG1024	Enoyl-CoA hydratase
C2U30_18265	COG4221	oxidoreductase activity
C2U30_18270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U30_18275	COG0442	prolyl-tRNA aminoacylation
C2U30_18280	COG0840	transmembrane signaling receptor activity
C2U30_18285	COG0632	four-way junction helicase activity
C2U30_18290	COG2255	four-way junction helicase activity
C2U30_18295	COG1271	oxidase subunit
C2U30_18300	COG1294	oxidase, subunit
C2U30_18305	COG4890	Cyd operon protein YbgT
C2U30_18310	COG3790	cyd operon protein YbgE
C2U30_18315	COG0824	Thioesterase
C2U30_18320	COG0811	peptide transport
C2U30_18335	COG0823	Involved in the tonB-independent uptake of proteins
C2U30_18340	COG2885	chlorophyll binding
C2U30_18345	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U30_18420	COG0840	transmembrane signaling receptor activity
C2U30_18425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U30_18430	COG0676	glucose-6-phosphate 1-epimerase activity
C2U30_18435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U30_18440	COG1640	4-alpha-glucanotransferase
C2U30_18445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U30_18475	COG2130	NADP-dependent
C2U30_18480	COG1846	Transcriptional regulator
C2U30_18495	COG1522	sequence-specific DNA binding
C2U30_18510	COG0561	phosphatase activity
C2U30_18525	COG0733	neurotransmitter:sodium symporter activity
C2U30_18530	COG0733	neurotransmitter:sodium symporter activity
C2U30_18545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U30_18560	COG1794	racemase activity, acting on amino acids and derivatives
C2U30_18570	COG1022	Amp-dependent synthetase and ligase
C2U30_18595	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2U30_18600	COG5001	Diguanylate cyclase
C2U30_18600	COG5002	protein histidine kinase activity
C2U30_18605	COG3706	GGDEF domain
C2U30_18605	COG0745	RESPONSE REGULATOR receiver
C2U30_18620	COG0456	acetyltransferase
C2U30_18630	COG0456	acetyltransferase
C2U30_18635	COG1902	pentaerythritol trinitrate reductase activity
C2U30_18650	COG2957	Belongs to the agmatine deiminase family
C2U30_18655	COG0154	amidase activity
C2U30_18660	COG2801	Transposase and inactivated derivatives
C2U30_18680	COG1917	Cupin 2, conserved barrel domain protein
C2U30_18680	COG2207	Transcriptional regulator
C2U30_18690	COG0513	Belongs to the DEAD box helicase family
C2U30_18695	COG2199	diguanylate cyclase activity
C2U30_18695	COG2203	Gaf domain
C2U30_18730	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U30_18745	COG0577	efflux transmembrane transporter activity
C2U30_18745	COG1136	(ABC) transporter
C2U30_18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_18755	COG0745	RESPONSE REGULATOR receiver
C2U30_18760	COG2205	protein histidine kinase activity
C2U30_18815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U30_18825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U30_18830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U30_18835	COG1178	ABC-type Fe3 transport system permease component
C2U30_18840	COG4143	(ABC) transporter
C2U30_18855	COG0066	3-isopropylmalate dehydratase activity
C2U30_18860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U30_18865	COG0473	3-isopropylmalate dehydrogenase activity
C2U30_18870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U30_18895	COG0028	Belongs to the TPP enzyme family
C2U30_18905	COG0440	acetolactate synthase activity
C2U30_18910	COG0280	phosphate acetyltransferase
C2U30_18910	COG0857	belongs to the CobB CobQ family
C2U30_18915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U30_18920	COG3092	negative regulation of chromosome organization
C2U30_18925	COG3013	Belongs to the UPF0304 family
C2U30_18930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U30_18935	COG2716	regulation of RNA biosynthetic process
C2U30_18940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U30_18945	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U30_18950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U30_18965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U30_18985	COG5002	protein histidine kinase activity
C2U30_18985	COG2198	Histidine kinase
C2U30_18985	COG0784	Response regulator, receiver
C2U30_19000	COG0784	Response regulator, receiver
C2U30_19000	COG2205	protein histidine kinase activity
C2U30_19020	COG1464	Belongs to the NlpA lipoprotein family
C2U30_19025	COG2011	ABC-type metal ion transport system permease component
C2U30_19030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U30_19050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U30_19050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U30_19055	COG0802	atpase or kinase
C2U30_19065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U30_19070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U30_19075	COG1923	regulation of RNA biosynthetic process
C2U30_19080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U30_19085	COG0330	HflC and HflK could
C2U30_19090	COG0330	HflC and HflK could
C2U30_19095	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U30_19100	COG0142	geranyltranstransferase activity
C2U30_19105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U30_19110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U30_19115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U30_19125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U30_19130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U30_19140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U30_19150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U30_19155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U30_19165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U30_19170	COG3178	'Phosphotransferase
C2U30_19175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U30_19180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U30_19190	COG2252	PERMEase
C2U30_19200	COG0488	(ABC) transporter
C2U30_19205	COG0582	viral genome integration into host DNA
C2U30_19215	COG0629	single-stranded DNA binding
C2U30_19405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U30_19410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U30_19415	COG2135	peptidase activity
C2U30_19455	COG1802	Transcriptional regulator
C2U30_19455	COG4626	Terminase
C2U30_19470	COG0616	signal peptide processing
C2U30_19575	COG0741	lytic transglycosylase activity
C2U30_19595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U30_19620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U30_19630	COG3721	Heme iron utilization protein
C2U30_19635	COG0748	coenzyme F420 binding
C2U30_19660	COG2814	Major facilitator Superfamily
C2U30_19665	COG2205	protein histidine kinase activity
C2U30_19665	COG2202	Pas domain
C2U30_19675	COG2226	methyltransferase
C2U30_19680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U30_19685	COG1765	OsmC-like protein
C2U30_19700	COG3954	Phosphoribulokinase
C2U30_19705	COG3089	Belongs to the UPF0270 family
C2U30_19710	COG3706	GGDEF domain
C2U30_19710	COG4251	negative regulation of phosphorylation
C2U30_19710	COG2203	Gaf domain
C2U30_19710	COG5001	Diguanylate cyclase
C2U30_19715	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U30_19720	COG0835	chemotaxis
C2U30_19720	COG0784	Response regulator, receiver
C2U30_19730	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U30_19735	COG1047	Peptidyl-prolyl cis-trans
C2U30_19740	COG2900	Belongs to the SlyX family
C2U30_19750	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U30_19755	COG2204	response regulator
C2U30_19775	COG0737	Belongs to the 5'-nucleotidase family
C2U30_19785	COG0305	Participates in initiation and elongation during chromosome replication
C2U30_19790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U30_19795	COG0506	proline dehydrogenase activity
C2U30_19795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U30_19795	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U30_19805	COG0114	fumarate hydratase activity
C2U30_19815	COG1566	PFAM secretion protein HlyD family protein
C2U30_19860	COG2203	Gaf domain
C2U30_19860	COG2200	EAL domain
C2U30_19860	COG2199	diguanylate cyclase activity
C2U30_19895	COG1280	lysine exporter protein (LysE YggA)
C2U30_19900	COG0826	peptidase U32
C2U30_19910	COG3813	Protein conserved in bacteria
C2U30_19930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U30_19955	COG0300	oxidoreductase activity
C2U30_19975	COG2610	gluconate transmembrane transporter activity
C2U30_19980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U30_19985	COG3622	Belongs to the hyi family
C2U30_19990	COG0235	Class ii aldolase
C2U30_20000	COG2084	Dehydrogenase
C2U30_20005	COG1349	DNA-binding transcription factor activity
C2U30_20015	COG2133	pyrroloquinoline quinone binding
C2U30_20050	COG0077	Prephenate dehydratase
C2U30_20050	COG1605	Chorismate mutase
C2U30_20075	COG3272	Protein of unknown function (DUF1722)
C2U30_20080	COG0789	Transcriptional regulator
C2U30_20085	COG0415	Belongs to the DNA photolyase family
C2U30_20095	COG4221	oxidoreductase activity
C2U30_20110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U30_20135	COG0783	Belongs to the Dps family
C2U30_20140	COG1151	hydroxylamine reductase activity
C2U30_20150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U30_20170	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U30_20175	COG2723	6-phospho-beta-galactosidase activity
C2U30_20185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U30_20205	COG2182	Extracellular solute-binding protein
C2U30_20210	COG1609	Transcriptional regulator
C2U30_20230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_20235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_20245	COG5002	protein histidine kinase activity
C2U30_20245	COG5000	phosphorelay sensor kinase activity
C2U30_20250	COG0659	secondary active sulfate transmembrane transporter activity
C2U30_20260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U30_20265	COG1666	GTP binding
C2U30_20270	COG3248	Nucleoside-binding outer membrane protein
C2U30_20275	COG2211	Major facilitator Superfamily
C2U30_20285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U30_20295	COG2813	Specifically methylates the guanine in position
C2U30_20300	COG0271	Belongs to the BolA IbaG family
C2U30_20305	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U30_20310	COG1805	sodium ion transport
C2U30_20315	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U30_20320	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U30_20325	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U30_20330	COG2871	sodium ion transport
C2U30_20335	COG1477	protein flavinylation
C2U30_20350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U30_20355	COG0840	transmembrane signaling receptor activity
C2U30_20360	COG0583	DNA-binding transcription factor activity
C2U30_20375	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U30_20385	COG0473	3-isopropylmalate dehydrogenase activity
C2U30_20390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U30_20395	COG1611	Belongs to the LOG family
C2U30_20400	COG3706	GGDEF domain
C2U30_20410	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U30_20410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U30_20420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U30_20445	COG3098	single-species biofilm formation
C2U30_20450	COG0564	pseudouridine synthase activity
C2U30_20455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U30_20470	COG1263	PTS System
C2U30_20470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U30_20480	COG2171	N-acyltransferase activity
C2U30_20485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U30_20490	COG0024	Methionine aminopeptidase
C2U30_20495	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U30_20500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U30_20505	COG0528	UMP kinase activity
C2U30_20510	COG0233	cytoplasmic translational termination
C2U30_20520	COG0575	Belongs to the CDS family
C2U30_20525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U30_20530	COG0750	zinc metalloprotease
C2U30_20545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U30_20550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U30_20555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U30_20560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U30_20565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U30_20575	COG0825	malonyl-CoA metabolic process
C2U30_20590	COG0814	amino acid
C2U30_20595	COG0531	amino acid
C2U30_20610	COG0488	(ABC) transporter
C2U30_20620	COG3590	peptidase
C2U30_20625	COG0037	tRNA processing
C2U30_20630	COG3706	GGDEF domain
C2U30_20670	COG0366	Alpha amylase catalytic
C2U30_20685	COG0463	Glycosyl transferase, family 2
C2U30_20700	COG2989	Protein conserved in bacteria
C2U30_20705	COG3108	Peptidase M15
C2U30_20715	COG2860	membrane
C2U30_20730	COG3115	cell septum assembly
C2U30_20735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U30_20745	COG1328	CTP reductase activity
C2U30_20750	COG0602	queuosine metabolic process
C2U30_20775	COG1566	PFAM secretion protein HlyD family protein
C2U30_20785	COG3290	protein histidine kinase activity
C2U30_20800	COG0667	Aldo Keto reductase
C2U30_20805	COG0697	spore germination
C2U30_20815	COG1012	belongs to the aldehyde dehydrogenase family
C2U30_20820	COG3284	Transcriptional regulator
C2U30_20825	COG3706	GGDEF domain
C2U30_20830	COG0346	lactoylglutathione lyase activity
C2U30_20835	COG0745	RESPONSE REGULATOR receiver
C2U30_20840	COG5002	protein histidine kinase activity
C2U30_20850	COG4783	chaperone-mediated protein folding
C2U30_20860	COG1940	carbohydrate kinase activity
C2U30_20865	COG3142	Participates in the control of copper homeostasis
C2U30_20875	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U30_20880	COG1131	(ABC) transporter
C2U30_20895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_20900	COG4597	amino acid ABC transporter
C2U30_20905	COG0765	amino acid transport
C2U30_20910	COG1126	abc transporter atp-binding protein
C2U30_20920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U30_20925	COG0678	peroxiredoxin activity
C2U30_20960	COG0733	neurotransmitter:sodium symporter activity
C2U30_20965	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U30_20970	COG3706	GGDEF domain
C2U30_20980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_20985	COG1032	radical SAM domain protein
C2U30_21020	COG0673	inositol 2-dehydrogenase activity
C2U30_21025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U30_21030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U30_21045	COG0741	lytic transglycosylase activity
C2U30_21045	COG0739	heme binding
C2U30_21045	COG1196	nuclear chromosome segregation
C2U30_21070	COG0788	formyltetrahydrofolate deformylase activity
C2U30_21075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U30_21085	COG3118	belongs to the thioredoxin family
C2U30_21095	COG0791	NLP P60 protein
C2U30_21100	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U30_21115	COG1388	LysM domain
C2U30_21115	COG1376	ErfK ybiS ycfS ynhG family protein
C2U30_21125	COG2205	protein histidine kinase activity
C2U30_21125	COG0784	Response regulator, receiver
C2U30_21150	COG2205	protein histidine kinase activity
C2U30_21150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U30_21155	COG3384	dioxygenase
C2U30_21165	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U30_21175	COG0531	amino acid
C2U30_21180	COG0531	amino acid
C2U30_21195	COG1012	belongs to the aldehyde dehydrogenase family
C2U30_21200	COG1396	sequence-specific DNA binding
C2U30_21200	COG1917	Cupin 2, conserved barrel domain protein
C2U30_21205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U30_21240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U30_21240	COG4651	solute:proton antiporter activity
C2U30_21245	COG0405	Gamma-glutamyltransferase
C2U30_21255	COG2974	May be involved in recombination
C2U30_21260	COG1247	-acetyltransferase
C2U30_21265	COG0420	3'-5' exonuclease activity
C2U30_21275	COG3038	cytochrome b561
C2U30_21280	COG2190	(PTS) system
C2U30_21290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U30_21295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U30_21300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U30_21315	COG1720	tRNA m6t6A37 methyltransferase activity
C2U30_21335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U30_21340	COG4988	ABC transporter
C2U30_21355	COG0745	RESPONSE REGULATOR receiver
C2U30_21365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U30_21380	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U30_21385	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U30_21400	COG0083	homoserine kinase activity
C2U30_21405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U30_21435	COG3220	belongs to the UPF0276 family
C2U30_21465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U30_21470	COG1289	transmembrane transporter activity
C2U30_21475	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U30_21480	COG0746	molybdenum cofactor guanylyltransferase activity
C2U30_21485	COG0281	malic enzyme
C2U30_21515	COG1196	nuclear chromosome segregation
C2U30_21515	COG3264	Mechanosensitive ion channel
C2U30_21525	COG2850	peptidyl-arginine hydroxylation
C2U30_21530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U30_21535	COG2915	High frequency lysogenization protein hflD homolog
C2U30_21540	COG0482	sulfurtransferase activity
C2U30_21550	COG1187	pseudouridine synthase activity
C2U30_21590	COG0538	isocitrate dehydrogenase activity
C2U30_21600	COG3048	D-serine ammonia-lyase activity
C2U30_21605	COG0583	DNA-binding transcription factor activity
C2U30_21610	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U30_21615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U30_21620	COG2375	cellular response to nickel ion
C2U30_21625	COG1538	Outer membrane efflux protein
C2U30_21630	COG0577	efflux transmembrane transporter activity
C2U30_21630	COG1136	(ABC) transporter
C2U30_21635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_21645	COG0497	DNA recombination
C2U30_21650	COG3706	GGDEF domain
C2U30_21655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U30_21660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U30_21665	COG0443	Heat shock 70 kDa protein
C2U30_21670	COG0484	heat shock protein binding
C2U30_21700	COG1285	pathogenesis
C2U30_21710	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U30_21720	COG0640	Transcriptional regulator
C2U30_21730	COG2391	methyltransferase activity
C2U30_21750	COG0095	Lipoate-protein ligase
C2U30_21765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_21770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_21780	COG0708	Exodeoxyribonuclease III
C2U30_21805	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U30_21820	COG1846	Transcriptional regulator
C2U30_21840	COG0583	DNA-binding transcription factor activity
C2U30_21845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U30_21850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U30_21855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U30_21860	COG1845	cytochrome c oxidase, subunit III
C2U30_21865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U30_21870	COG0109	protoheme IX farnesyltransferase activity
C2U30_21880	COG2814	Major facilitator Superfamily
C2U30_21885	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U30_21895	COG0583	DNA-binding transcription factor activity
C2U30_21915	COG3550	peptidyl-serine autophosphorylation
C2U30_21920	COG1396	sequence-specific DNA binding
C2U30_21945	COG0159	tryptophan synthase activity
C2U30_21950	COG0133	tryptophan synthase activity
C2U30_21955	COG0134	indole-3-glycerol-phosphate synthase activity
C2U30_21955	COG0135	phosphoribosylanthranilate isomerase activity
C2U30_21960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U30_21965	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U30_21965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U30_21970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U30_21980	COG0613	PHP domain protein
C2U30_21985	COG0009	L-threonylcarbamoyladenylate synthase
C2U30_21995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U30_22005	COG1946	Acyl-CoA thioesterase
C2U30_22020	COG1309	transcriptional regulator
C2U30_22025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U30_22030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_22035	COG1538	Outer membrane efflux protein
C2U30_22040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U30_22115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U30_22125	COG1960	acyl-CoA dehydrogenase activity
C2U30_22130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U30_22140	COG0469	pyruvate kinase activity
C2U30_22145	COG1737	Transcriptional regulator
C2U30_22155	COG2205	protein histidine kinase activity
C2U30_22160	COG0745	RESPONSE REGULATOR receiver
C2U30_22170	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U30_22200	COG2244	polysaccharide biosynthetic process
C2U30_22210	COG0110	maltose O-acetyltransferase activity
C2U30_22215	COG0438	transferase activity, transferring glycosyl groups
C2U30_22230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U30_22240	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2U30_22255	COG3132	Protein of unknown function, DUF480
C2U30_22280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U30_22295	COG1278	Cold shock
C2U30_22320	COG4166	transmembrane transport
C2U30_22325	COG0697	spore germination
C2U30_22335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U30_22345	COG1187	pseudouridine synthase activity
C2U30_22355	COG4166	transmembrane transport
C2U30_22360	COG0622	Phosphoesterase
C2U30_22380	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U30_22385	COG0835	chemotaxis
C2U30_22385	COG0784	Response regulator, receiver
C2U30_22390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U30_22395	COG1815	bacterial-type flagellum-dependent cell motility
C2U30_22400	COG1558	bacterial-type flagellum-dependent cell motility
C2U30_22410	COG1749	Flagellar hook protein flgE
C2U30_22420	COG4786	Flagellar basal body rod
C2U30_22425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U30_22430	COG1706	bacterial-type flagellum-dependent cell motility
C2U30_22435	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U30_22435	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U30_22440	COG1280	lysine exporter protein (LysE YggA)
C2U30_22480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U30_22535	COG1192	Involved in chromosome partitioning