locus-tag	class	description
C2U47_00005	COG5001	Diguanylate cyclase
C2U47_00005	COG3300	MHYT domain
C2U47_00015	COG0583	DNA-binding transcription factor activity
C2U47_00020	COG0745	RESPONSE REGULATOR receiver
C2U47_00045	COG4989	oxidoreductase activity
C2U47_00050	COG0724	RNA recognition motif
C2U47_00060	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U47_00070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U47_00135	COG1002	Type II restriction enzyme, methylase subunits
C2U47_00140	COG1061	Type III restriction enzyme res subunit
C2U47_00150	COG4584	PFAM Integrase catalytic
C2U47_00155	COG1484	DNA-dependent DNA replication
C2U47_00185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_00190	COG1360	Flagellar Motor Protein
C2U47_00195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_00200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_00220	COG1034	ATP synthesis coupled electron transport
C2U47_00225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U47_00230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_00235	COG0839	Belongs to the complex I subunit 6 family
C2U47_00240	COG0713	ATP synthesis coupled electron transport
C2U47_00250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_00255	COG1007	ATP synthesis coupled electron transport
C2U47_00260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U47_00260	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U47_00265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U47_00275	COG1645	bacterial-type flagellum-dependent swarming motility
C2U47_00280	COG1160	GTP binding
C2U47_00285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_00290	COG2976	Protein conserved in bacteria
C2U47_00295	COG0124	histidyl-tRNA synthetase
C2U47_00305	COG1426	Protein conserved in bacteria
C2U47_00315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U47_00320	COG0105	UTP biosynthetic process
C2U47_00335	COG0633	Ferredoxin
C2U47_00340	COG0443	Heat shock 70 kDa protein
C2U47_00355	COG0822	iron-sulfur transferase activity
C2U47_00360	COG1104	cysteine desulfurase activity
C2U47_00395	COG2897	thiosulfate sulfurtransferase activity
C2U47_00400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_00405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_00410	COG1862	Preprotein translocase
C2U47_00415	COG0343	queuine tRNA-ribosyltransferase activity
C2U47_00420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U47_00425	COG0517	IMP dehydrogenase activity
C2U47_00430	COG0450	alkyl hydroperoxide reductase
C2U47_00435	COG3634	alkyl hydroperoxide reductase activity
C2U47_00500	COG3385	transposase activity
C2U47_00520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_00535	COG3012	SEC-C Motif Domain Protein
C2U47_00535	COG3318	Belongs to the UPF0149 family
C2U47_00555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U47_00555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U47_00560	COG0509	glycine decarboxylation via glycine cleavage system
C2U47_00565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U47_00570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_00595	COG2814	Major facilitator Superfamily
C2U47_00600	COG0444	Belongs to the ABC transporter superfamily
C2U47_00605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_00610	COG0601	transmembrane transport
C2U47_00620	COG0625	glutathione transferase activity
C2U47_00625	COG0625	glutathione transferase activity
C2U47_00635	COG0483	inositol monophosphate 1-phosphatase activity
C2U47_00650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_00655	COG2056	Na+-H+ antiporter family
C2U47_00660	COG2814	Major facilitator Superfamily
C2U47_00665	COG0583	DNA-binding transcription factor activity
C2U47_00670	COG5001	Diguanylate cyclase
C2U47_00685	COG2050	protein possibly involved in aromatic compounds catabolism
C2U47_00695	COG0277	FAD linked oxidase domain protein
C2U47_00695	COG0247	lactate metabolic process
C2U47_00710	COG1253	flavin adenine dinucleotide binding
C2U47_00715	COG1902	pentaerythritol trinitrate reductase activity
C2U47_00725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U47_00730	COG0647	UMP catabolic process
C2U47_00740	COG0367	asparagine synthase
C2U47_00755	COG0625	glutathione transferase activity
C2U47_00765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U47_00780	COG0564	pseudouridine synthase activity
C2U47_00785	COG5001	Diguanylate cyclase
C2U47_00790	COG0840	transmembrane signaling receptor activity
C2U47_00795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U47_00830	COG0670	Belongs to the BI1 family
C2U47_00835	COG1289	transmembrane transporter activity
C2U47_00840	COG2920	part of a sulfur-relay system
C2U47_00845	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U47_00850	COG0285	dihydrofolate synthase activity
C2U47_00855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U47_00860	COG0101	tRNA pseudouridine synthase activity
C2U47_00870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U47_00875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U47_00885	COG1464	Belongs to the NlpA lipoprotein family
C2U47_00915	COG1119	ATPase activity
C2U47_00920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U47_00920	COG0574	Belongs to the PEP-utilizing enzyme family
C2U47_00925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U47_00935	COG1113	amino acid transport
C2U47_01010	COG1242	4 iron, 4 sulfur cluster binding
C2U47_01015	COG0069	glutamate synthase activity
C2U47_01015	COG0070	glutamate synthase
C2U47_01015	COG0067	glutamate synthase
C2U47_01020	COG0493	'glutamate synthase
C2U47_01030	COG0765	amino acid transport
C2U47_01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_01060	COG4104	PAAR repeat-containing protein
C2U47_01070	COG0513	Belongs to the DEAD box helicase family
C2U47_01100	COG3706	GGDEF domain
C2U47_01105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U47_01110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U47_01115	COG0505	Belongs to the CarA family
C2U47_01120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U47_01130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U47_01135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U47_01140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U47_01145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U47_01150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_01155	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U47_01160	COG4139	cobalamin transport
C2U47_01195	COG0023	Translation Initiation Factor
C2U47_01200	COG2119	membrane
C2U47_01240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U47_01250	COG2801	Transposase and inactivated derivatives
C2U47_01265	COG0215	cysteine-tRNA ligase activity
C2U47_01270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U47_01280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_01285	COG2261	transglycosylase associated protein
C2U47_01290	COG1309	transcriptional regulator
C2U47_01295	COG0604	alcohol dehydrogenase
C2U47_01305	COG0402	S-adenosylhomocysteine deaminase activity
C2U47_01310	COG0583	DNA-binding transcription factor activity
C2U47_01335	COG0322	excinuclease ABC activity
C2U47_01340	COG2197	response regulator
C2U47_01345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U47_01350	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U47_01355	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U47_01360	COG1132	(ABC) transporter
C2U47_01365	COG0658	competence protein
C2U47_01365	COG2333	competence protein COMEC
C2U47_01380	COG0433	COG0433 Predicted ATPase
C2U47_01385	COG1448	Aminotransferase
C2U47_01395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U47_01400	COG1199	ATP-dependent helicase activity
C2U47_01410	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U47_01415	COG0477	Major facilitator Superfamily
C2U47_01425	COG1785	Belongs to the alkaline phosphatase family
C2U47_01445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U47_01455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_01460	COG0765	amino acid transport
C2U47_01465	COG1126	abc transporter atp-binding protein
C2U47_01475	COG0531	amino acid
C2U47_01495	COG1253	flavin adenine dinucleotide binding
C2U47_01500	COG0704	Plays a role in the regulation of phosphate uptake
C2U47_01510	COG0581	inorganic phosphate transmembrane transporter activity
C2U47_01515	COG0573	inorganic phosphate transmembrane transporter activity
C2U47_01520	COG0590	tRNA wobble adenosine to inosine editing
C2U47_01535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U47_01555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U47_01560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U47_01565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U47_01570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U47_01575	COG2204	response regulator
C2U47_01585	COG2204	response regulator
C2U47_01595	COG2716	regulation of RNA biosynthetic process
C2U47_01600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U47_01605	COG0248	Ppx GppA phosphatase
C2U47_01615	COG0675	Transposase, IS605 OrfB family
C2U47_01625	COG2239	Acts as a magnesium transporter
C2U47_01660	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U47_01660	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U47_01665	COG1706	bacterial-type flagellum-dependent cell motility
C2U47_01670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U47_01675	COG4786	Flagellar basal body rod
C2U47_01685	COG1749	Flagellar hook protein flgE
C2U47_01695	COG1558	bacterial-type flagellum-dependent cell motility
C2U47_01700	COG1815	bacterial-type flagellum-dependent cell motility
C2U47_01705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U47_01710	COG0835	chemotaxis
C2U47_01710	COG0784	Response regulator, receiver
C2U47_01715	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U47_01730	COG0622	Phosphoesterase
C2U47_01735	COG0675	Transposase, IS605 OrfB family
C2U47_01745	COG4166	transmembrane transport
C2U47_01755	COG1187	pseudouridine synthase activity
C2U47_01760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_01765	COG0675	Transposase, IS605 OrfB family
C2U47_01775	COG0697	spore germination
C2U47_01815	COG1278	Cold shock
C2U47_01855	COG3132	Protein of unknown function, DUF480
C2U47_01865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_01885	COG3206	protein involved in exopolysaccharide biosynthesis
C2U47_01885	COG0489	protein tyrosine kinase activity
C2U47_01890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U47_01910	COG0297	glycogen (starch) synthase activity
C2U47_01915	COG1215	transferase activity, transferring glycosyl groups
C2U47_01920	COG0463	Glycosyl transferase, family 2
C2U47_01950	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U47_02035	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U47_02045	COG0745	RESPONSE REGULATOR receiver
C2U47_02060	COG1737	Transcriptional regulator
C2U47_02065	COG0469	pyruvate kinase activity
C2U47_02075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_02080	COG1960	acyl-CoA dehydrogenase activity
C2U47_02090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U47_02145	COG1538	Outer membrane efflux protein
C2U47_02160	COG1309	transcriptional regulator
C2U47_02170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U47_02175	COG1946	Acyl-CoA thioesterase
C2U47_02190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U47_02200	COG0009	L-threonylcarbamoyladenylate synthase
C2U47_02205	COG0613	PHP domain protein
C2U47_02210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U47_02215	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U47_02215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U47_02220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U47_02225	COG0134	indole-3-glycerol-phosphate synthase activity
C2U47_02225	COG0135	phosphoribosylanthranilate isomerase activity
C2U47_02230	COG0133	tryptophan synthase activity
C2U47_02235	COG0159	tryptophan synthase activity
C2U47_02245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U47_02250	COG1396	sequence-specific DNA binding
C2U47_02255	COG3550	peptidyl-serine autophosphorylation
C2U47_02290	COG4521	taurine ABC transporter
C2U47_02295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U47_02300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U47_02305	COG2175	clavaminate synthase activity
C2U47_02315	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U47_02320	COG2814	Major facilitator Superfamily
C2U47_02325	COG0109	protoheme IX farnesyltransferase activity
C2U47_02330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U47_02335	COG1845	cytochrome c oxidase, subunit III
C2U47_02340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U47_02345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U47_02355	COG0583	DNA-binding transcription factor activity
C2U47_02370	COG0675	Transposase, IS605 OrfB family
C2U47_02385	COG1846	Transcriptional regulator
C2U47_02400	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U47_02425	COG0708	Exodeoxyribonuclease III
C2U47_02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_02445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_02460	COG0095	Lipoate-protein ligase
C2U47_02490	COG0640	Transcriptional regulator
C2U47_02500	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_02510	COG1285	pathogenesis
C2U47_02540	COG0484	heat shock protein binding
C2U47_02545	COG0443	Heat shock 70 kDa protein
C2U47_02550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U47_02555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U47_02565	COG0497	DNA recombination
C2U47_02575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_02580	COG0577	efflux transmembrane transporter activity
C2U47_02580	COG1136	(ABC) transporter
C2U47_02585	COG1538	Outer membrane efflux protein
C2U47_02590	COG2375	cellular response to nickel ion
C2U47_02595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_02600	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_02605	COG0583	DNA-binding transcription factor activity
C2U47_02610	COG3048	D-serine ammonia-lyase activity
C2U47_02620	COG0538	isocitrate dehydrogenase activity
C2U47_02655	COG0456	acetyltransferase
C2U47_02660	COG1187	pseudouridine synthase activity
C2U47_02670	COG0482	sulfurtransferase activity
C2U47_02675	COG2915	High frequency lysogenization protein hflD homolog
C2U47_02680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U47_02685	COG2850	peptidyl-arginine hydroxylation
C2U47_02695	COG1196	nuclear chromosome segregation
C2U47_02695	COG3264	Mechanosensitive ion channel
C2U47_02705	COG2706	6-phosphogluconolactonase activity
C2U47_02730	COG0746	molybdenum cofactor guanylyltransferase activity
C2U47_02740	COG1289	transmembrane transporter activity
C2U47_02745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_02775	COG3220	belongs to the UPF0276 family
C2U47_02785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U47_02800	COG3039	Transposase
C2U47_02820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U47_02825	COG0083	homoserine kinase activity
C2U47_02840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U47_02845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U47_02860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U47_02870	COG0745	RESPONSE REGULATOR receiver
C2U47_02885	COG4988	ABC transporter
C2U47_02890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U47_02910	COG1720	tRNA m6t6A37 methyltransferase activity
C2U47_02925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U47_02930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U47_02935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_02945	COG2190	(PTS) system
C2U47_02950	COG3038	cytochrome b561
C2U47_02965	COG0420	3'-5' exonuclease activity
C2U47_02975	COG2974	May be involved in recombination
C2U47_02985	COG0405	Gamma-glutamyltransferase
C2U47_02990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U47_02990	COG4651	solute:proton antiporter activity
C2U47_03000	COG3385	transposase activity
C2U47_03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_03035	COG1917	Cupin 2, conserved barrel domain protein
C2U47_03035	COG1396	sequence-specific DNA binding
C2U47_03040	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_03050	COG0531	amino acid
C2U47_03055	COG0531	amino acid
C2U47_03065	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U47_03075	COG3384	dioxygenase
C2U47_03105	COG2205	protein histidine kinase activity
C2U47_03105	COG0784	Response regulator, receiver
C2U47_03115	COG1376	ErfK ybiS ycfS ynhG family protein
C2U47_03115	COG1388	LysM domain
C2U47_03135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U47_03140	COG0791	NLP P60 protein
C2U47_03150	COG3118	belongs to the thioredoxin family
C2U47_03160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U47_03165	COG0788	formyltetrahydrofolate deformylase activity
C2U47_03190	COG0741	lytic transglycosylase activity
C2U47_03190	COG1196	nuclear chromosome segregation
C2U47_03190	COG0739	heme binding
C2U47_03200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U47_03205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U47_03210	COG0673	inositol 2-dehydrogenase activity
C2U47_03230	COG1032	radical SAM domain protein
C2U47_03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_03245	COG3706	GGDEF domain
C2U47_03250	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U47_03285	COG0281	malic enzyme
C2U47_03290	COG2207	Transcriptional regulator
C2U47_03305	COG0745	RESPONSE REGULATOR receiver
C2U47_03305	COG3706	GGDEF domain
C2U47_03315	COG0095	Lipoate-protein ligase
C2U47_03320	COG1115	amino acid carrier protein
C2U47_03325	COG0019	diaminopimelate decarboxylase activity
C2U47_03335	COG0678	peroxiredoxin activity
C2U47_03340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U47_03350	COG1126	abc transporter atp-binding protein
C2U47_03355	COG0765	amino acid transport
C2U47_03360	COG4597	amino acid ABC transporter
C2U47_03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_03380	COG1131	(ABC) transporter
C2U47_03385	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U47_03405	COG3142	Participates in the control of copper homeostasis
C2U47_03410	COG1940	carbohydrate kinase activity
C2U47_03420	COG4783	chaperone-mediated protein folding
C2U47_03430	COG5002	protein histidine kinase activity
C2U47_03435	COG0745	RESPONSE REGULATOR receiver
C2U47_03440	COG0346	lactoylglutathione lyase activity
C2U47_03445	COG3706	GGDEF domain
C2U47_03455	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_03465	COG0697	spore germination
C2U47_03475	COG0667	Aldo Keto reductase
C2U47_03490	COG3290	protein histidine kinase activity
C2U47_03500	COG1566	PFAM secretion protein HlyD family protein
C2U47_03525	COG0602	queuosine metabolic process
C2U47_03530	COG1328	CTP reductase activity
C2U47_03540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U47_03545	COG3115	cell septum assembly
C2U47_03560	COG2860	membrane
C2U47_03570	COG3108	Peptidase M15
C2U47_03575	COG2989	Protein conserved in bacteria
C2U47_03590	COG0463	Glycosyl transferase, family 2
C2U47_03605	COG0366	Alpha amylase catalytic
C2U47_03650	COG3706	GGDEF domain
C2U47_03655	COG0037	tRNA processing
C2U47_03670	COG0488	(ABC) transporter
C2U47_03680	COG0531	amino acid
C2U47_03685	COG0814	amino acid
C2U47_03700	COG0825	malonyl-CoA metabolic process
C2U47_03705	COG0587	DNA-directed DNA polymerase activity
C2U47_03710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U47_03715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_03720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_03725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U47_03730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_03745	COG0750	zinc metalloprotease
C2U47_03750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U47_03755	COG0575	Belongs to the CDS family
C2U47_03765	COG0233	cytoplasmic translational termination
C2U47_03770	COG0528	UMP kinase activity
C2U47_03775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U47_03780	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U47_03785	COG0024	Methionine aminopeptidase
C2U47_03790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U47_03795	COG2171	N-acyltransferase activity
C2U47_03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_03805	COG1263	PTS System
C2U47_03815	COG4580	involved in the transport of maltose and maltodextrins
C2U47_03825	COG0564	pseudouridine synthase activity
C2U47_03830	COG3098	single-species biofilm formation
C2U47_03855	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U47_03865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U47_03865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U47_03875	COG3706	GGDEF domain
C2U47_03880	COG1611	Belongs to the LOG family
C2U47_03885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_03890	COG0473	3-isopropylmalate dehydrogenase activity
C2U47_03900	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U47_03915	COG0583	DNA-binding transcription factor activity
C2U47_03920	COG0840	transmembrane signaling receptor activity
C2U47_03925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U47_03940	COG1477	protein flavinylation
C2U47_03945	COG2871	sodium ion transport
C2U47_03950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_03955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_03960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_03965	COG1805	sodium ion transport
C2U47_03970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_03975	COG0271	Belongs to the BolA IbaG family
C2U47_03980	COG2813	Specifically methylates the guanine in position
C2U47_03990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U47_04000	COG2211	Major facilitator Superfamily
C2U47_04010	COG1666	GTP binding
C2U47_04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U47_04025	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_04030	COG5002	protein histidine kinase activity
C2U47_04035	COG0745	RESPONSE REGULATOR receiver
C2U47_04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_04045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_04075	COG1609	Transcriptional regulator
C2U47_04080	COG2182	Extracellular solute-binding protein
C2U47_04085	COG0840	transmembrane signaling receptor activity
C2U47_04100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U47_04110	COG2723	6-phospho-beta-galactosidase activity
C2U47_04115	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U47_04135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U47_04145	COG1151	hydroxylamine reductase activity
C2U47_04150	COG0783	Belongs to the Dps family
C2U47_04190	COG4221	oxidoreductase activity
C2U47_04200	COG0415	Belongs to the DNA photolyase family
C2U47_04205	COG0789	Transcriptional regulator
C2U47_04210	COG3272	Protein of unknown function (DUF1722)
C2U47_04235	COG0077	Prephenate dehydratase
C2U47_04235	COG1605	Chorismate mutase
C2U47_04265	COG2133	pyrroloquinoline quinone binding
C2U47_04275	COG1349	DNA-binding transcription factor activity
C2U47_04280	COG2084	Dehydrogenase
C2U47_04285	COG3395	kinase activity
C2U47_04290	COG0235	Class ii aldolase
C2U47_04295	COG3622	Belongs to the hyi family
C2U47_04300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U47_04305	COG2610	gluconate transmembrane transporter activity
C2U47_04325	COG0300	oxidoreductase activity
C2U47_04350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U47_04370	COG3813	Protein conserved in bacteria
C2U47_04380	COG0826	peptidase U32
C2U47_04385	COG1280	lysine exporter protein (LysE YggA)
C2U47_04420	COG2203	Gaf domain
C2U47_04420	COG2199	diguanylate cyclase activity
C2U47_04420	COG2200	EAL domain
C2U47_04455	COG3504	Conjugal transfer protein
C2U47_04480	COG3451	type IV secretory pathway VirB4
C2U47_04490	COG3838	Conjugal transfer protein Trbc
C2U47_04495	COG4962	Type ii secretion system protein e
C2U47_04525	COG4804	nuclease activity
C2U47_04530	COG2003	Belongs to the UPF0758 family
C2U47_04550	COG2076	Multidrug Resistance protein
C2U47_04580	COG4962	Type ii secretion system protein e
C2U47_04585	COG3838	Conjugal transfer protein Trbc
C2U47_04595	COG3451	type IV secretory pathway VirB4
C2U47_04610	COG3846	protein secretion by the type IV secretion system
C2U47_04670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U47_04675	COG1127	ABC transporter
C2U47_04700	COG4959	Type IV secretory pathway protease TraF
C2U47_04715	COG1192	Involved in chromosome partitioning
C2U47_04755	COG5489	Protein of unknown function (DUF736)
C2U47_04790	COG2003	Belongs to the UPF0758 family
C2U47_04795	COG4804	nuclease activity
C2U47_04825	COG1566	PFAM secretion protein HlyD family protein
C2U47_04835	COG0114	fumarate hydratase activity
C2U47_04845	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U47_04845	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U47_04845	COG0506	proline dehydrogenase activity
C2U47_04850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_04855	COG0305	Participates in initiation and elongation during chromosome replication
C2U47_04865	COG0737	Belongs to the 5'-nucleotidase family
C2U47_04885	COG2204	response regulator
C2U47_04890	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U47_04900	COG2900	Belongs to the SlyX family
C2U47_04905	COG1047	Peptidyl-prolyl cis-trans
C2U47_04910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U47_04920	COG0784	Response regulator, receiver
C2U47_04920	COG0835	chemotaxis
C2U47_04925	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U47_04930	COG2203	Gaf domain
C2U47_04930	COG4251	negative regulation of phosphorylation
C2U47_04930	COG5001	Diguanylate cyclase
C2U47_04930	COG3706	GGDEF domain
C2U47_04935	COG3089	Belongs to the UPF0270 family
C2U47_04940	COG3954	Phosphoribulokinase
C2U47_04955	COG1765	OsmC-like protein
C2U47_04960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U47_04965	COG2226	methyltransferase
C2U47_04975	COG2205	protein histidine kinase activity
C2U47_04975	COG2202	Pas domain
C2U47_04980	COG2814	Major facilitator Superfamily
C2U47_05005	COG0748	coenzyme F420 binding
C2U47_05010	COG3721	Heme iron utilization protein
C2U47_05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_05045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U47_05055	COG0463	Glycosyl transferase, family 2
C2U47_05060	COG0739	heme binding
C2U47_05060	COG0741	lytic transglycosylase activity
C2U47_05060	COG1196	nuclear chromosome segregation
C2U47_05065	COG0488	(ABC) transporter
C2U47_05075	COG2252	PERMEase
C2U47_05080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U47_05085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U47_05090	COG3178	'Phosphotransferase
C2U47_05095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U47_05105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U47_05110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U47_05120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U47_05130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U47_05135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_05145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U47_05150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U47_05155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U47_05160	COG0142	geranyltranstransferase activity
C2U47_05165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U47_05170	COG0330	HflC and HflK could
C2U47_05175	COG0330	HflC and HflK could
C2U47_05180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U47_05185	COG1923	regulation of RNA biosynthetic process
C2U47_05190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U47_05195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U47_05205	COG0802	atpase or kinase
C2U47_05210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U47_05210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U47_05230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U47_05235	COG2011	ABC-type metal ion transport system permease component
C2U47_05240	COG1464	Belongs to the NlpA lipoprotein family
C2U47_05260	COG0784	Response regulator, receiver
C2U47_05260	COG2205	protein histidine kinase activity
C2U47_05275	COG2198	Histidine kinase
C2U47_05275	COG5002	protein histidine kinase activity
C2U47_05275	COG0784	Response regulator, receiver
C2U47_05295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U47_05310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U47_05315	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U47_05320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U47_05325	COG2716	regulation of RNA biosynthetic process
C2U47_05330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U47_05335	COG3013	Belongs to the UPF0304 family
C2U47_05340	COG3092	negative regulation of chromosome organization
C2U47_05345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U47_05350	COG0280	phosphate acetyltransferase
C2U47_05350	COG0857	belongs to the CobB CobQ family
C2U47_05355	COG0440	acetolactate synthase activity
C2U47_05360	COG0028	Belongs to the TPP enzyme family
C2U47_05375	COG0671	phosphoesterase, PA-phosphatase related
C2U47_05385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U47_05390	COG0473	3-isopropylmalate dehydrogenase activity
C2U47_05395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U47_05400	COG0066	3-isopropylmalate dehydratase activity
C2U47_05415	COG4143	(ABC) transporter
C2U47_05420	COG1178	ABC-type Fe3 transport system permease component
C2U47_05425	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U47_05430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U47_05440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_05470	COG0316	Belongs to the HesB IscA family
C2U47_05480	COG0038	chloride channel
C2U47_05485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U47_05500	COG0671	phosphoesterase, PA-phosphatase related
C2U47_05510	COG0583	DNA-binding transcription factor activity
C2U47_05515	COG2076	Multidrug Resistance protein
C2U47_05525	COG0346	lactoylglutathione lyase activity
C2U47_05530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U47_05535	COG1643	Atp-dependent helicase
C2U47_05545	COG1489	DNA binding
C2U47_05550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U47_05555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_05565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U47_05570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U47_05575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U47_05585	COG0842	Transport permease protein
C2U47_05590	COG1131	(ABC) transporter
C2U47_05605	COG0163	prenyltransferase activity
C2U47_05610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U47_05615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U47_05630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U47_05645	COG1136	(ABC) transporter
C2U47_05690	COG2801	Transposase and inactivated derivatives
C2U47_05695	COG0529	Catalyzes the synthesis of activated sulfate
C2U47_05700	COG3273	potassium ion transport
C2U47_05700	COG0471	metal ion transport
C2U47_05705	COG2895	sulfate adenylyltransferase (ATP) activity
C2U47_05710	COG0175	sulfate reduction
C2U47_05720	COG0330	HflC and HflK could
C2U47_05725	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U47_05735	COG0673	inositol 2-dehydrogenase activity
C2U47_05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U47_05750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U47_05755	COG3036	rescue of stalled ribosome
C2U47_05770	COG0138	bifunctional purine biosynthesis protein purh
C2U47_05775	COG0151	Belongs to the GarS family
C2U47_05805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U47_05810	COG0358	DNA primase activity
C2U47_05815	COG1610	YqeY-like protein
C2U47_05820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U47_05825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U47_05835	COG1388	LysM domain
C2U47_05835	COG4942	peptidase
C2U47_05840	COG1238	metal cluster binding
C2U47_05845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U47_05850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U47_05855	COG0585	pseudouridine synthase activity
C2U47_05865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U47_05870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U47_05875	COG0148	phosphopyruvate hydratase activity
C2U47_05880	COG0504	CTP synthase activity
C2U47_05885	COG3956	TIGRFAM MazG family protein
C2U47_05890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U47_05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_05905	COG4807	Protein conserved in bacteria
C2U47_05910	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U47_05915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U47_05920	COG1381	Involved in DNA repair and RecF pathway recombination
C2U47_05930	COG0571	ribonuclease III activity
C2U47_05935	COG0681	Belongs to the peptidase S26 family
C2U47_05940	COG0481	GTPase activity
C2U47_05955	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U47_05960	COG1595	DNA-templated transcription, initiation
C2U47_05965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U47_05975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U47_05985	COG0583	DNA-binding transcription factor activity
C2U47_06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_06025	COG0126	phosphoglycerate kinase activity
C2U47_06030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U47_06035	COG1940	carbohydrate kinase activity
C2U47_06040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U47_06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U47_06070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U47_06075	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_06090	COG1505	serine-type exopeptidase activity
C2U47_06095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U47_06100	COG0765	amino acid transport
C2U47_06105	COG0765	amino acid transport
C2U47_06110	COG1126	abc transporter atp-binding protein
C2U47_06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_06120	COG3174	membrane
C2U47_06125	COG0110	maltose O-acetyltransferase activity
C2U47_06155	COG1942	4-Oxalocrotonate Tautomerase
C2U47_06165	COG0583	DNA-binding transcription factor activity
C2U47_06170	COG0165	Argininosuccinate lyase
C2U47_06175	COG0137	argininosuccinate synthase activity
C2U47_06185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U47_06190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U47_06200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U47_06205	COG3447	MASE1 domain protein
C2U47_06205	COG5001	Diguanylate cyclase
C2U47_06205	COG5002	protein histidine kinase activity
C2U47_06210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U47_06245	COG0583	DNA-binding transcription factor activity
C2U47_06250	COG1380	Effector of murein hydrolase LrgA
C2U47_06255	COG1346	cytolysis
C2U47_06260	COG0527	aspartate kinase activity
C2U47_06260	COG0460	homoserine dehydrogenase
C2U47_06265	COG0626	cystathionine gamma-synthase activity
C2U47_06280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_06285	COG0814	amino acid
C2U47_06290	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U47_06295	COG0494	nUDIX hydrolase
C2U47_06300	COG1011	Hydrolase
C2U47_06305	COG1902	pentaerythritol trinitrate reductase activity
C2U47_06315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U47_06330	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U47_06340	COG3156	type II secretion system protein K
C2U47_06350	COG4795	General secretion pathway protein
C2U47_06355	COG2165	general secretion pathway protein
C2U47_06365	COG2165	general secretion pathway protein
C2U47_06370	COG1459	type II secretion system
C2U47_06375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U47_06385	COG3031	protein transport across the cell outer membrane
C2U47_06395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U47_06400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U47_06415	COG0456	acetyltransferase
C2U47_06420	COG3133	Outer membrane lipoprotein
C2U47_06425	COG3025	triphosphatase activity
C2U47_06430	COG1392	Phosphate transport regulator
C2U47_06435	COG0306	phosphate transporter
C2U47_06440	COG0617	tRNA 3'-terminal CCA addition
C2U47_06445	COG3267	Type II secretory pathway component ExeA
C2U47_06445	COG3409	Peptidoglycan-binding domain 1 protein
C2U47_06455	COG1194	a g-specific adenine glycosylase
C2U47_06460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U47_06475	COG3240	lipase activity
C2U47_06485	COG3009	Protein conserved in bacteria
C2U47_06490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U47_06490	COG3008	intermembrane lipid transfer
C2U47_06495	COG2995	paraquat-inducible protein a
C2U47_06505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_06515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U47_06520	COG2813	Specifically methylates the guanine in position
C2U47_06530	COG0297	glycogen (starch) synthase activity
C2U47_06570	COG1757	Na H antiporter
C2U47_06580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U47_06585	COG3842	ATPase activity
C2U47_06590	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U47_06595	COG1177	transmembrane transport
C2U47_06600	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_06605	COG0109	protoheme IX farnesyltransferase activity
C2U47_06635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U47_06645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U47_06645	COG1565	acr, cog1565
C2U47_06650	COG1444	tRNA N-acetyltransferase activity
C2U47_06670	COG1803	Methylglyoxal synthase
C2U47_06705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_06705	COG1263	PTS System
C2U47_06710	COG0366	Alpha amylase catalytic
C2U47_06715	COG0110	maltose O-acetyltransferase activity
C2U47_06720	COG1522	sequence-specific DNA binding
C2U47_06750	COG3068	Protein conserved in bacteria
C2U47_06760	COG0739	heme binding
C2U47_06780	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U47_06785	COG1121	(ABC) transporter
C2U47_06790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U47_06795	COG0583	DNA-binding transcription factor activity
C2U47_06805	COG1573	uracil-dna glycosylase
C2U47_06810	COG2962	Rard protein
C2U47_06815	COG2827	Endonuclease containing a URI domain
C2U47_06830	COG1842	Phage shock protein A
C2U47_06835	COG0204	Acyl-transferase
C2U47_06855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_06865	COG0484	heat shock protein binding
C2U47_06920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U47_06930	COG3039	Transposase
C2U47_06995	COG2801	Transposase and inactivated derivatives
C2U47_07020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_07030	COG0789	Transcriptional regulator
C2U47_07105	COG4974	Belongs to the 'phage' integrase family
C2U47_07120	COG0795	lipopolysaccharide-transporting ATPase activity
C2U47_07125	COG0795	lipopolysaccharide-transporting ATPase activity
C2U47_07130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U47_07135	COG2927	DNA polymerase III (CHI subunit)
C2U47_07140	COG0525	valine-tRNA ligase activity
C2U47_07145	COG1253	flavin adenine dinucleotide binding
C2U47_07150	COG0586	Pfam SNARE associated Golgi protein
C2U47_07155	COG1686	Belongs to the peptidase S11 family
C2U47_07190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U47_07195	COG0527	aspartate kinase activity
C2U47_07200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U47_07205	COG2137	regulation of response to DNA damage stimulus
C2U47_07210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U47_07215	COG1546	Belongs to the CinA family
C2U47_07225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U47_07270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U47_07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U47_07295	COG0523	cobalamin synthesis protein
C2U47_07305	COG1280	lysine exporter protein (LysE YggA)
C2U47_07315	COG2200	EAL domain
C2U47_07320	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U47_07330	COG0840	transmembrane signaling receptor activity
C2U47_07335	COG0840	transmembrane signaling receptor activity
C2U47_07345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U47_07350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U47_07355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U47_07360	COG2186	Transcriptional regulator
C2U47_07390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U47_07395	COG1459	type II secretion system
C2U47_07400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2U47_07410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U47_07415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U47_07420	COG0494	nUDIX hydrolase
C2U47_07430	COG0653	protein targeting
C2U47_07440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U47_07445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U47_07450	COG0849	cell division
C2U47_07455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U47_07460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U47_07465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U47_07470	COG0772	Belongs to the SEDS family
C2U47_07475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U47_07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U47_07490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U47_07495	COG0768	penicillin binding
C2U47_07500	COG3116	cell division
C2U47_07505	COG0275	rRNA processing
C2U47_07510	COG2001	Belongs to the MraZ family
C2U47_07520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U47_07525	COG3107	peptidoglycan biosynthetic process
C2U47_07530	COG0792	nuclease activity
C2U47_07535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U47_07540	COG2823	Periplasmic or secreted lipoprotein
C2U47_07545	COG2969	positive regulation of protein catabolic process
C2U47_07550	COG0625	glutathione transferase activity
C2U47_07555	COG2857	Cytochrome c1
C2U47_07560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U47_07565	COG0723	plastoquinol--plastocyanin reductase activity
C2U47_07570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U47_07575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U47_07580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U47_07590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U47_07595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U47_07625	COG3964	amidohydrolase
C2U47_07645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_07650	COG1660	Displays ATPase and GTPase activities
C2U47_07655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_07665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U47_07670	COG1137	ATPase activity
C2U47_07675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U47_07685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U47_07690	COG0517	IMP dehydrogenase activity
C2U47_07690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U47_07695	COG1127	ABC transporter
C2U47_07700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U47_07705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U47_07710	COG2854	intermembrane phospholipid transfer
C2U47_07720	COG5007	Belongs to the BolA IbaG family
C2U47_07725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U47_07735	COG1494	fructose-1,6-bisphosphatase
C2U47_07745	COG2226	methyltransferase
C2U47_07770	COG1733	regulation of RNA biosynthetic process
C2U47_07790	COG3932	Exopolysaccharide synthesis, ExoD
C2U47_07795	COG2199	diguanylate cyclase activity
C2U47_07795	COG2203	Gaf domain
C2U47_07805	COG0110	maltose O-acetyltransferase activity
C2U47_07825	COG2801	Transposase and inactivated derivatives
C2U47_07830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U47_07835	COG2022	thiamine diphosphate biosynthetic process
C2U47_07845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U47_07850	COG0352	thiamine-phosphate diphosphorylase activity
C2U47_07855	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U47_07870	COG0745	RESPONSE REGULATOR receiver
C2U47_07880	COG0189	ligase activity
C2U47_07915	COG2321	neutral zinc metallopeptidase
C2U47_07925	COG0477	Major facilitator Superfamily
C2U47_07940	COG0312	modulator of DNA gyrase
C2U47_07945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_07950	COG3164	Protein of unknown function
C2U47_07955	COG1530	ribonuclease E activity
C2U47_07960	COG0424	maF-like protein
C2U47_07965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U47_07970	COG1792	Involved in formation and maintenance of cell shape
C2U47_07975	COG1077	Cell shape determining protein MreB Mrl
C2U47_08020	COG1459	type II secretion system
C2U47_08075	COG2200	EAL domain
C2U47_08080	COG0387	Pfam Sodium calcium exchanger
C2U47_08085	COG2986	histidine ammonia-lyase
C2U47_08090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U47_08095	COG0010	Belongs to the arginase family
C2U47_08100	COG1228	amidohydrolase
C2U47_08105	COG2188	Transcriptional regulator
C2U47_08110	COG0288	reversible hydration of carbon dioxide
C2U47_08120	COG2177	Part of the ABC transporter FtsEX involved in
C2U47_08125	COG2884	Cell division ATP-binding protein ftsE
C2U47_08130	COG0552	protein localization to endoplasmic reticulum
C2U47_08135	COG0742	ribosomal rna small subunit methyltransferase
C2U47_08160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U47_08165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U47_08175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_08185	COG2095	MarC family integral membrane protein
C2U47_08195	COG1301	dicarboxylic acid transport
C2U47_08205	COG0583	DNA-binding transcription factor activity
C2U47_08220	COG3714	YhhN family
C2U47_08255	COG4221	oxidoreductase activity
C2U47_08260	COG0583	DNA-binding transcription factor activity
C2U47_08265	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U47_08335	COG0203	ribosomal protein L17
C2U47_08340	COG0202	RNA polymerase activity
C2U47_08345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U47_08350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U47_08355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U47_08360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U47_08365	COG0201	protein transport
C2U47_08370	COG0200	Binds to the 23S rRNA
C2U47_08375	COG1841	ribosomal large subunit assembly
C2U47_08380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U47_08385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U47_08390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U47_08395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U47_08400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U47_08405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U47_08410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U47_08415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U47_08420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U47_08425	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U47_08430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U47_08435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U47_08440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U47_08445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U47_08450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U47_08455	COG0089	rRNA binding
C2U47_08460	COG0088	Forms part of the polypeptide exit tunnel
C2U47_08465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U47_08470	COG0051	transcription antitermination factor activity, RNA binding
C2U47_08480	COG2205	protein histidine kinase activity
C2U47_08485	COG0745	RESPONSE REGULATOR receiver
C2U47_08495	COG2183	response to ionizing radiation
C2U47_08510	COG0596	Alpha beta hydrolase
C2U47_08515	COG1040	competence protein
C2U47_08520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U47_08520	COG0316	Belongs to the HesB IscA family
C2U47_08525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U47_08530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U47_08535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_08540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U47_08545	COG4942	peptidase
C2U47_08555	COG1609	Transcriptional regulator
C2U47_08570	COG0800	Aldolase
C2U47_08575	COG0129	dihydroxy-acid dehydratase activity
C2U47_08580	COG3265	gluconokinase activity
C2U47_08585	COG2610	gluconate transmembrane transporter activity
C2U47_08590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U47_08595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U47_08605	COG0456	acetyltransferase
C2U47_08615	COG1490	D-aminoacyl-tRNA deacylase activity
C2U47_08620	COG1295	ribonuclease BN
C2U47_08630	COG0174	glutamine synthetase
C2U47_08640	COG3852	Histidine kinase
C2U47_08650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U47_08655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U47_08665	COG3078	GTPase activator activity
C2U47_08675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U47_08685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U47_08690	COG0408	coproporphyrinogen oxidase activity
C2U47_08695	COG0009	L-threonylcarbamoyladenylate synthase
C2U47_08700	COG0551	DNA topoisomerase type I activity
C2U47_08705	COG2922	Belongs to the Smg family
C2U47_08710	COG0758	DNA mediated transformation
C2U47_08720	COG0242	peptide deformylase activity
C2U47_08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U47_08730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_08730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_08735	COG0569	domain protein
C2U47_08740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U47_08745	COG1322	Protein conserved in bacteria
C2U47_08765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_08775	COG0519	Catalyzes the synthesis of GMP from XMP
C2U47_08775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U47_08790	COG1396	sequence-specific DNA binding
C2U47_08795	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_08810	COG1280	lysine exporter protein (LysE YggA)
C2U47_08850	COG0583	DNA-binding transcription factor activity
C2U47_08855	COG1943	Transposase
C2U47_08870	COG3039	Transposase
C2U47_08880	COG0210	DNA helicase
C2U47_08915	COG0583	DNA-binding transcription factor activity
C2U47_08940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U47_08945	COG0385	Bile acid
C2U47_08950	COG0531	amino acid
C2U47_08955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_08960	COG0531	amino acid
C2U47_08965	COG2731	YhcH YjgK YiaL family protein
C2U47_08970	COG3250	beta-galactosidase activity
C2U47_08975	COG1609	Transcriptional regulator
C2U47_09010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U47_09015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_09015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_09020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U47_09025	COG3074	FtsZ-dependent cytokinesis
C2U47_09035	COG1045	serine acetyltransferase
C2U47_09045	COG0745	RESPONSE REGULATOR receiver
C2U47_09050	COG2205	protein histidine kinase activity
C2U47_09055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U47_09060	COG0534	Mate efflux family protein
C2U47_09075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U47_09080	COG2937	Belongs to the GPAT DAPAT family
C2U47_09090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U47_09095	COG3161	chorismate lyase activity
C2U47_09100	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U47_09120	COG1609	Transcriptional regulator
C2U47_09170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U47_09185	COG1063	alcohol dehydrogenase
C2U47_09205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U47_09210	COG2166	iron-sulfur cluster assembly
C2U47_09215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U47_09250	COG3655	Transcriptional regulator
C2U47_09265	COG5433	transposase activity
C2U47_09325	COG2855	membrane
C2U47_09340	COG3385	transposase activity
C2U47_09345	COG1484	DNA-dependent DNA replication
C2U47_09350	COG4584	PFAM Integrase catalytic
C2U47_09385	COG5433	transposase activity
C2U47_09460	COG5433	transposase activity
C2U47_09475	COG2207	Transcriptional regulator
C2U47_09475	COG4753	response regulator
C2U47_09480	COG0642	Histidine kinase
C2U47_09485	COG0745	RESPONSE REGULATOR receiver
C2U47_09490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_09520	COG3385	transposase activity
C2U47_09535	COG1484	DNA-dependent DNA replication
C2U47_09540	COG4584	PFAM Integrase catalytic
C2U47_09580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U47_09605	COG1484	DNA-dependent DNA replication
C2U47_09640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_09645	COG0840	transmembrane signaling receptor activity
C2U47_09650	COG3039	Transposase
C2U47_09655	COG3385	transposase activity
C2U47_09685	COG4584	PFAM Integrase catalytic
C2U47_09690	COG1484	DNA-dependent DNA replication
C2U47_09740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U47_09745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U47_09750	COG2223	nitrite transmembrane transporter activity
C2U47_09755	COG3279	Response regulator of the LytR AlgR family
C2U47_09760	COG3275	phosphorelay sensor kinase activity
C2U47_09770	COG2205	protein histidine kinase activity
C2U47_09770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_09790	COG3188	usher protein
C2U47_09805	COG1280	lysine exporter protein (LysE YggA)
C2U47_09810	COG2223	nitrite transmembrane transporter activity
C2U47_09815	COG2081	HI0933 family
C2U47_09820	COG1528	Iron-storage protein
C2U47_09825	COG3706	GGDEF domain
C2U47_09830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U47_09840	COG0589	response to stress
C2U47_09880	COG3642	lipopolysaccharide core region biosynthetic process
C2U47_09885	COG0859	PFAM glycosyl transferase family 9
C2U47_09900	COG1758	RNA polymerase activity
C2U47_09905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U47_09910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U47_09915	COG2267	carboxylic ester hydrolase activity
C2U47_09920	COG0561	phosphatase activity
C2U47_09950	COG1309	transcriptional regulator
C2U47_09955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_09960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_09965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_09965	COG4191	Histidine kinase
C2U47_09970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U47_09995	COG2205	protein histidine kinase activity
C2U47_10000	COG0745	RESPONSE REGULATOR receiver
C2U47_10005	COG2814	Major facilitator Superfamily
C2U47_10020	COG3977	Valine--pyruvate aminotransferase
C2U47_10025	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U47_10030	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U47_10035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U47_10040	COG2207	Transcriptional regulator
C2U47_10045	COG0187	DNA topoisomerase II activity
C2U47_10055	COG0592	DNA-directed DNA polymerase activity
C2U47_10060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U47_10080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U47_10085	COG0594	ribonuclease P activity
C2U47_10090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U47_10095	COG0706	membrane insertase activity
C2U47_10100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U47_10125	COG3550	peptidyl-serine autophosphorylation
C2U47_10135	COG3385	transposase activity
C2U47_10145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_10150	COG1120	ATPase activity
C2U47_10155	COG4615	Cyclic peptide transporter
C2U47_10160	COG4774	siderophore transport
C2U47_10165	COG0716	FMN binding
C2U47_10170	COG0445	tRNA wobble uridine modification
C2U47_10175	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U47_10180	COG1192	Involved in chromosome partitioning
C2U47_10185	COG1475	DNA binding
C2U47_10195	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U47_10205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U47_10210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U47_10215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U47_10220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U47_10225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U47_10230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U47_10235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U47_10240	COG4452	Inner membrane protein CreD
C2U47_10255	COG0745	RESPONSE REGULATOR receiver
C2U47_10260	COG1349	DNA-binding transcription factor activity
C2U47_10265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U47_10310	COG1111	helicase
C2U47_10310	COG1205	dead DEAH box helicase
C2U47_10315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U47_10345	COG2771	luxR family
C2U47_10355	COG0811	peptide transport
C2U47_10360	COG0811	peptide transport
C2U47_10365	COG0848	biopolymer transport protein
C2U47_10370	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U47_10405	COG0402	S-adenosylhomocysteine deaminase activity
C2U47_10410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U47_10420	COG3165	ubiquinone biosynthetic process from chorismate
C2U47_10425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U47_10430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_10435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_10440	COG0805	protein transport
C2U47_10445	COG0084	hydrolase, TatD family'
C2U47_10465	COG0742	ribosomal rna small subunit methyltransferase
C2U47_10475	COG0248	Ppx GppA phosphatase
C2U47_10480	COG0513	Belongs to the DEAD box helicase family
C2U47_10485	COG3118	belongs to the thioredoxin family
C2U47_10490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U47_10500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U47_10510	COG2960	long-chain fatty acid transporting porin activity
C2U47_10525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_10555	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U47_10565	COG1609	Transcriptional regulator
C2U47_10570	COG3604	Transcriptional regulator
C2U47_10575	COG1773	rubredoxin
C2U47_10575	COG0426	domain, Protein
C2U47_10580	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_10590	COG0348	domain, Protein
C2U47_10605	COG0814	amino acid
C2U47_10610	COG0814	amino acid
C2U47_10630	COG4251	negative regulation of phosphorylation
C2U47_10630	COG5001	Diguanylate cyclase
C2U47_10630	COG2203	Gaf domain
C2U47_10630	COG3706	GGDEF domain
C2U47_10635	COG0751	glycine-tRNA ligase activity
C2U47_10640	COG0752	glycyl-tRNA synthetase alpha subunit
C2U47_10645	COG2818	Glycosylase
C2U47_10650	COG1335	isochorismatase
C2U47_10665	COG2885	chlorophyll binding
C2U47_10685	COG0251	oxidation-reduction process
C2U47_10690	COG0425	Belongs to the sulfur carrier protein TusA family
C2U47_10720	COG2205	protein histidine kinase activity
C2U47_10725	COG0745	RESPONSE REGULATOR receiver
C2U47_10730	COG0183	Belongs to the thiolase family
C2U47_10735	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U47_10735	COG1024	Enoyl-CoA hydratase
C2U47_10740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U47_10745	COG0006	proline dipeptidase activity
C2U47_10750	COG1739	Uncharacterized protein family UPF0029
C2U47_10755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U47_10760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U47_10785	COG1042	CoA-binding domain protein
C2U47_10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_10785	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U47_10795	COG0583	DNA-binding transcription factor activity
C2U47_10800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U47_10805	COG0166	Belongs to the GPI family
C2U47_10815	COG0668	transmembrane transport
C2U47_10825	COG1309	transcriptional regulator
C2U47_10830	COG0756	dUTP diphosphatase activity
C2U47_10835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U47_10840	COG2003	Belongs to the UPF0758 family
C2U47_10845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U47_10850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U47_10860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U47_10865	COG2990	Protein conserved in bacteria
C2U47_10870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U47_10875	COG0859	PFAM glycosyl transferase family 9
C2U47_10880	COG0463	Glycosyl transferase, family 2
C2U47_10885	COG0859	PFAM glycosyl transferase family 9
C2U47_10890	COG1519	Transferase
C2U47_10900	COG1561	YicC-like family, N-terminal region
C2U47_10905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U47_10910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U47_10925	COG5001	Diguanylate cyclase
C2U47_10925	COG3706	GGDEF domain
C2U47_10925	COG2203	Gaf domain
C2U47_10925	COG4251	negative regulation of phosphorylation
C2U47_10930	COG3084	Protein conserved in bacteria
C2U47_10940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U47_10945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U47_10955	COG1335	isochorismatase
C2U47_10965	COG1683	Conserved Protein
C2U47_10970	COG0204	Acyl-transferase
C2U47_10975	COG0204	Acyl-transferase
C2U47_11020	COG4584	PFAM Integrase catalytic
C2U47_11025	COG1484	DNA-dependent DNA replication
C2U47_11095	COG3978	acetolactate synthase activity
C2U47_11100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U47_11105	COG0129	dihydroxy-acid dehydratase activity
C2U47_11120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U47_11125	COG0254	rRNA binding
C2U47_11130	COG0702	epimerase
C2U47_11135	COG0281	malic enzyme
C2U47_11145	COG2205	protein histidine kinase activity
C2U47_11155	COG0745	RESPONSE REGULATOR receiver
C2U47_11160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_11205	COG0366	Alpha amylase catalytic
C2U47_11220	COG0443	Heat shock 70 kDa protein
C2U47_11225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U47_11230	COG3045	CreA protein
C2U47_11245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U47_11250	COG0174	glutamine synthetase
C2U47_11270	COG3842	ATPase activity
C2U47_11275	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U47_11280	COG1177	transmembrane transport
C2U47_11285	COG2258	MOSC domain
C2U47_11300	COG2050	protein possibly involved in aromatic compounds catabolism
C2U47_11305	COG0514	ATP-dependent DNA helicase (RecQ)
C2U47_11315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U47_11325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U47_11330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U47_11340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U47_11340	COG1648	precorrin-2 dehydrogenase activity
C2U47_11345	COG2116	formate transmembrane transporter activity
C2U47_11350	COG2146	nitrite reductase [NAD(P)H] activity
C2U47_11355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_11360	COG0842	Transport permease protein
C2U47_11365	COG0842	Transport permease protein
C2U47_11370	COG1131	(ABC) transporter
C2U47_11375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_11390	COG0477	Major facilitator Superfamily
C2U47_11395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U47_11400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U47_11420	COG1595	DNA-templated transcription, initiation
C2U47_11425	COG3806	Anti-sigma factor
C2U47_11430	COG1968	undecaprenyl-diphosphatase activity
C2U47_11435	COG0667	Aldo Keto reductase
C2U47_11440	COG2017	converts alpha-aldose to the beta-anomer
C2U47_11445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U47_11455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U47_11460	COG1609	Transcriptional regulator
C2U47_11465	COG3250	beta-galactosidase activity
C2U47_11505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U47_11515	COG1438	arginine binding
C2U47_11520	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U47_11525	COG0540	Belongs to the ATCase OTCase family
C2U47_11545	COG0583	DNA-binding transcription factor activity
C2U47_11565	COG3040	lipid binding
C2U47_11575	COG1979	alcohol dehydrogenase
C2U47_11580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U47_11585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U47_11590	COG2964	Protein conserved in bacteria
C2U47_11595	COG3681	Belongs to the UPF0597 family
C2U47_11600	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_11605	COG0564	pseudouridine synthase activity
C2U47_11615	COG0542	response to heat
C2U47_11620	COG0583	DNA-binding transcription factor activity
C2U47_11635	COG2502	aspartate--ammonia ligase
C2U47_11640	COG1522	sequence-specific DNA binding
C2U47_11650	COG0517	IMP dehydrogenase activity
C2U47_11650	COG0516	GMP reductase activity
C2U47_11670	COG2205	protein histidine kinase activity
C2U47_11680	COG2204	response regulator
C2U47_11695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U47_11715	COG0745	RESPONSE REGULATOR receiver
C2U47_11720	COG2205	protein histidine kinase activity
C2U47_11730	COG0243	molybdopterin cofactor binding
C2U47_11735	COG3005	denitrification pathway
C2U47_11740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U47_11750	COG0569	domain protein
C2U47_11755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U47_11780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U47_11790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U47_11795	COG0250	Participates in transcription elongation, termination and antitermination
C2U47_11800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U47_11805	COG0081	regulation of translation
C2U47_11810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U47_11815	COG0222	ribosome binding
C2U47_11820	COG0085	RNA polymerase activity
C2U47_11825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U47_11830	COG2964	Protein conserved in bacteria
C2U47_11835	COG0251	oxidation-reduction process
C2U47_11840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U47_11850	COG2168	tRNA wobble position uridine thiolation
C2U47_11855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U47_11860	COG0049	tRNA binding
C2U47_11865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U47_11870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U47_11875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U47_11910	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U47_11915	COG2252	PERMEase
C2U47_11920	COG2376	Dihydroxyacetone kinase
C2U47_11925	COG1461	Dihydroxyacetone kinase
C2U47_11940	COG0583	DNA-binding transcription factor activity
C2U47_11945	COG2957	Belongs to the agmatine deiminase family
C2U47_11975	COG0628	permease
C2U47_11980	COG0494	nUDIX hydrolase
C2U47_12000	COG0753	catalase activity
C2U47_12005	COG0456	acetyltransferase
C2U47_12025	COG0745	RESPONSE REGULATOR receiver
C2U47_12025	COG3706	GGDEF domain
C2U47_12035	COG3842	ATPase activity
C2U47_12045	COG1175	transmembrane transport
C2U47_12070	COG0583	DNA-binding transcription factor activity
C2U47_12080	COG1741	Belongs to the pirin family
C2U47_12085	COG2259	Doxx family
C2U47_12090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U47_12095	COG1074	ATP-dependent DNA helicase activity
C2U47_12100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U47_12105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U47_12120	COG0346	lactoylglutathione lyase activity
C2U47_12130	COG0004	ammonium transporteR
C2U47_12135	COG0347	Belongs to the P(II) protein family
C2U47_12140	COG3706	GGDEF domain
C2U47_12160	COG0745	RESPONSE REGULATOR receiver
C2U47_12170	COG1278	Cold shock
C2U47_12195	COG1396	sequence-specific DNA binding
C2U47_12215	COG3039	Transposase
C2U47_12255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U47_12290	COG2197	response regulator
C2U47_12300	COG3047	cAMP biosynthetic process
C2U47_12330	COG3135	benzoate transporter
C2U47_12335	COG1396	sequence-specific DNA binding
C2U47_12365	COG2926	Belongs to the UPF0265 family
C2U47_12375	COG3028	Belongs to the UPF0307 family
C2U47_12380	COG0312	modulator of DNA gyrase
C2U47_12385	COG3071	HemY protein
C2U47_12390	COG2959	enzyme of heme biosynthesis
C2U47_12400	COG0181	hydroxymethylbilane synthase activity
C2U47_12405	COG3072	Adenylate cyclase
C2U47_12410	COG0400	carboxylic ester hydrolase activity
C2U47_12415	COG1965	Belongs to the frataxin family
C2U47_12425	COG0019	diaminopimelate decarboxylase activity
C2U47_12430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U47_12445	COG1011	Hydrolase
C2U47_12455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U47_12460	COG0561	phosphatase activity
C2U47_12475	COG1988	membrane-bound metal-dependent
C2U47_12480	COG1058	Belongs to the CinA family
C2U47_12480	COG1546	Belongs to the CinA family
C2U47_12490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U47_12500	COG1522	sequence-specific DNA binding
C2U47_12505	COG1368	sulfuric ester hydrolase activity
C2U47_12520	COG1285	pathogenesis
C2U47_12540	COG4221	oxidoreductase activity
C2U47_12555	COG1979	alcohol dehydrogenase
C2U47_12565	COG2873	o-acetylhomoserine
C2U47_12595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U47_12610	COG2949	membrane
C2U47_12615	COG3291	Pkd domain containing protein
C2U47_12630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U47_12635	COG0596	Alpha beta hydrolase
C2U47_12640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U47_12645	COG1169	isochorismate synthase
C2U47_12650	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U47_12670	COG0513	Belongs to the DEAD box helicase family
C2U47_12675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_12690	COG1671	Belongs to the UPF0178 family
C2U47_12710	COG3263	regulation of cellular component size
C2U47_12715	COG3722	fumarate hydratase activity
C2U47_12720	COG0246	Mannitol dehydrogenase
C2U47_12730	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U47_12740	COG3916	Acyl-homoserine-lactone synthase
C2U47_12745	COG2771	luxR family
C2U47_12760	COG1560	Kdo2-lipid A biosynthetic process
C2U47_12765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U47_12765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U47_12775	COG1538	Outer membrane efflux protein
C2U47_12780	COG0494	nUDIX hydrolase
C2U47_12785	COG3151	Protein conserved in bacteria
C2U47_12795	COG3150	esterase
C2U47_12800	COG1051	belongs to the nudix hydrolase family
C2U47_12815	COG1566	PFAM secretion protein HlyD family protein
C2U47_12820	COG1289	transmembrane transporter activity
C2U47_12825	COG0187	DNA topoisomerase II activity
C2U47_12865	COG0004	ammonium transporteR
C2U47_12870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_12880	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U47_12885	COG0084	hydrolase, TatD family'
C2U47_12890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_12900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U47_12905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U47_12910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U47_12925	COG5001	Diguanylate cyclase
C2U47_12925	COG3447	MASE1 domain protein
C2U47_12925	COG5002	protein histidine kinase activity
C2U47_12935	COG0560	Phosphoserine phosphatase
C2U47_12950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U47_12960	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U47_12965	COG0776	regulation of translation
C2U47_12980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U47_12985	COG0735	belongs to the Fur family
C2U47_13005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U47_13010	COG0513	Belongs to the DEAD box helicase family
C2U47_13015	COG3022	response to hydroperoxide
C2U47_13020	COG2805	Type II/IV secretion system protein
C2U47_13030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U47_13035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U47_13040	COG0762	integral membrane protein
C2U47_13045	COG1872	DUF167
C2U47_13070	COG3835	regulator
C2U47_13075	COG2610	gluconate transmembrane transporter activity
C2U47_13080	COG1929	Belongs to the glycerate kinase type-1 family
C2U47_13095	COG0583	DNA-binding transcription factor activity
C2U47_13100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_13115	COG0347	Belongs to the P(II) protein family
C2U47_13130	COG3842	ATPase activity
C2U47_13135	COG2837	iron assimilation
C2U47_13140	COG1438	arginine binding
C2U47_13145	COG1126	abc transporter atp-binding protein
C2U47_13150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_13155	COG4215	(ABC) transporter
C2U47_13160	COG4160	amino acid transport
C2U47_13165	COG0039	L-malate dehydrogenase activity
C2U47_13175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U47_13180	COG1017	nitric oxide dioxygenase activity
C2U47_13180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_13190	COG4536	flavin adenine dinucleotide binding
C2U47_13195	COG4137	Cytochrome C assembly protein
C2U47_13200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U47_13205	COG0228	four-way junction DNA binding
C2U47_13210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U47_13215	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U47_13220	COG0335	large ribosomal subunit rRNA binding
C2U47_13245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U47_13250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U47_13255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U47_13265	COG0583	DNA-binding transcription factor activity
C2U47_13270	COG0640	Transcriptional regulator
C2U47_13275	COG0268	Binds directly to 16S ribosomal RNA
C2U47_13280	COG0728	peptidoglycan biosynthetic process
C2U47_13285	COG0196	riboflavin kinase activity
C2U47_13290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U47_13295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U47_13300	COG1047	Peptidyl-prolyl cis-trans
C2U47_13305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U47_13310	COG4968	Prepilin-type N-terminal cleavage methylation domain
C2U47_13360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_13360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U47_13375	COG1854	S-ribosylhomocysteine lyase activity
C2U47_13380	COG3706	GGDEF domain
C2U47_13385	COG0557	exoribonuclease II activity
C2U47_13390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U47_13400	COG2153	protein acetylation
C2U47_13410	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U47_13415	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U47_13420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U47_13425	COG0359	binds to the 23S rRNA
C2U47_13465	COG1238	metal cluster binding
C2U47_13470	COG0612	Peptidase, M16
C2U47_13475	COG2918	glutathione biosynthetic process
C2U47_13480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U47_13485	COG1027	Aspartate ammonia-lyase
C2U47_13490	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U47_13500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U47_13505	COG0459	protein refolding
C2U47_13525	COG0564	pseudouridine synthase activity
C2U47_13530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U47_13560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U47_13570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U47_13575	COG4208	sulfate ABC transporter
C2U47_13580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U47_13585	COG0583	DNA-binding transcription factor activity
C2U47_13590	COG3397	chitin binding
C2U47_13595	COG0840	transmembrane signaling receptor activity
C2U47_13620	COG1328	CTP reductase activity
C2U47_13625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U47_13635	COG0583	DNA-binding transcription factor activity
C2U47_13640	COG1448	Aminotransferase
C2U47_13645	COG2194	sulfuric ester hydrolase activity
C2U47_13665	COG1215	transferase activity, transferring glycosyl groups
C2U47_13675	COG0457	Tetratricopeptide repeat
C2U47_13675	COG3118	belongs to the thioredoxin family
C2U47_13710	COG0513	Belongs to the DEAD box helicase family
C2U47_13715	COG0840	transmembrane signaling receptor activity
C2U47_13725	COG4166	transmembrane transport
C2U47_13740	COG1024	Enoyl-CoA hydratase
C2U47_13755	COG4221	oxidoreductase activity
C2U47_13760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_13765	COG0442	prolyl-tRNA aminoacylation
C2U47_13770	COG0840	transmembrane signaling receptor activity
C2U47_13775	COG0632	four-way junction helicase activity
C2U47_13780	COG2255	four-way junction helicase activity
C2U47_13785	COG1271	oxidase subunit
C2U47_13790	COG1294	oxidase, subunit
C2U47_13795	COG4890	Cyd operon protein YbgT
C2U47_13800	COG3790	cyd operon protein YbgE
C2U47_13805	COG0824	Thioesterase
C2U47_13810	COG0811	peptide transport
C2U47_13825	COG0823	Involved in the tonB-independent uptake of proteins
C2U47_13830	COG2885	chlorophyll binding
C2U47_13835	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U47_13910	COG0840	transmembrane signaling receptor activity
C2U47_13915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U47_13925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U47_13930	COG1640	4-alpha-glucanotransferase
C2U47_13935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U47_13965	COG2130	NADP-dependent
C2U47_13970	COG1846	Transcriptional regulator
C2U47_13985	COG1522	sequence-specific DNA binding
C2U47_14000	COG0561	phosphatase activity
C2U47_14015	COG0733	neurotransmitter:sodium symporter activity
C2U47_14020	COG0733	neurotransmitter:sodium symporter activity
C2U47_14035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_14050	COG1794	racemase activity, acting on amino acids and derivatives
C2U47_14060	COG1022	Amp-dependent synthetase and ligase
C2U47_14070	COG0456	acetyltransferase
C2U47_14090	COG5002	protein histidine kinase activity
C2U47_14090	COG5001	Diguanylate cyclase
C2U47_14095	COG3706	GGDEF domain
C2U47_14095	COG0745	RESPONSE REGULATOR receiver
C2U47_14110	COG0456	acetyltransferase
C2U47_14120	COG0456	acetyltransferase
C2U47_14125	COG1902	pentaerythritol trinitrate reductase activity
C2U47_14135	COG2852	Protein conserved in bacteria
C2U47_14145	COG2957	Belongs to the agmatine deiminase family
C2U47_14150	COG0154	amidase activity
C2U47_14160	COG2801	Transposase and inactivated derivatives
C2U47_14185	COG2207	Transcriptional regulator
C2U47_14185	COG1917	Cupin 2, conserved barrel domain protein
C2U47_14195	COG0513	Belongs to the DEAD box helicase family
C2U47_14200	COG2199	diguanylate cyclase activity
C2U47_14200	COG2203	Gaf domain
C2U47_14235	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U47_14245	COG0577	efflux transmembrane transporter activity
C2U47_14245	COG1136	(ABC) transporter
C2U47_14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_14255	COG0745	RESPONSE REGULATOR receiver
C2U47_14260	COG2205	protein histidine kinase activity
C2U47_14310	COG1280	lysine exporter protein (LysE YggA)
C2U47_14315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U47_14330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_14360	COG0745	RESPONSE REGULATOR receiver
C2U47_14365	COG3104	oligopeptide transport
C2U47_14370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U47_14375	COG1555	photosystem II stabilization
C2U47_14385	COG2350	Protein conserved in bacteria
C2U47_14390	COG2917	probably involved in intracellular septation
C2U47_14395	COG0076	glutamate decarboxylase activity
C2U47_14400	COG1272	protein, Hemolysin III
C2U47_14405	COG0569	domain protein
C2U47_14405	COG2985	domain, Protein
C2U47_14425	COG0477	Major facilitator Superfamily
C2U47_14430	COG0583	DNA-binding transcription factor activity
C2U47_14435	COG3227	Zinc metalloprotease (Elastase)
C2U47_14440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_14445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_14455	COG2731	YhcH YjgK YiaL family protein
C2U47_14465	COG0668	transmembrane transport
C2U47_14475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U47_14490	COG0789	Transcriptional regulator
C2U47_14500	COG3039	Transposase
C2U47_14530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U47_14540	COG0488	(ABC) transporter
C2U47_14545	COG0516	GMP reductase activity
C2U47_14545	COG0517	IMP dehydrogenase activity
C2U47_14555	COG0784	Response regulator, receiver
C2U47_14555	COG0835	chemotaxis
C2U47_14560	COG2755	lipolytic protein G-D-S-L family
C2U47_14565	COG4181	ATPase activity
C2U47_14570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U47_14575	COG1090	epimerase
C2U47_14580	COG2200	EAL domain
C2U47_14585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_14590	COG4935	Belongs to the peptidase S8 family
C2U47_14590	COG2234	aminopeptidase activity
C2U47_14595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U47_14600	COG3171	Protein conserved in bacteria
C2U47_14605	COG2066	Belongs to the glutaminase family
C2U47_14610	COG2897	thiosulfate sulfurtransferase activity
C2U47_14625	COG1132	(ABC) transporter
C2U47_14650	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U47_14655	COG5001	Diguanylate cyclase
C2U47_14655	COG3300	MHYT domain
C2U47_14675	COG4628	conserved protein (DUF2132)
C2U47_14680	COG0688	phosphatidylethanolamine metabolic process
C2U47_14685	COG1162	GTPase activity
C2U47_14690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U47_14730	COG1278	Cold shock
C2U47_14740	COG0840	transmembrane signaling receptor activity
C2U47_14745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_14750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_14815	COG0848	biopolymer transport protein
C2U47_14820	COG0811	peptide transport
C2U47_14825	COG0811	peptide transport
C2U47_14835	COG4206	TonB-dependent receptor
C2U47_14840	COG4174	ABC transporter (Permease)
C2U47_14845	COG4239	(ABC) transporter, permease
C2U47_14855	COG0444	Belongs to the ABC transporter superfamily
C2U47_14860	COG4608	Belongs to the ABC transporter superfamily
C2U47_14870	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U47_14880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U47_14900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U47_14925	COG0243	molybdopterin cofactor binding
C2U47_14930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U47_14930	COG1648	precorrin-2 dehydrogenase activity
C2U47_14945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U47_14950	COG1116	anion transmembrane transporter activity
C2U47_14955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_14955	COG2146	nitrite reductase [NAD(P)H] activity
C2U47_14960	COG2146	nitrite reductase [NAD(P)H] activity
C2U47_14960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_14970	COG2313	pseudouridylate synthase activity
C2U47_14990	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U47_15000	COG2966	Psort location CytoplasmicMembrane, score
C2U47_15005	COG3610	response to peptide
C2U47_15015	COG4175	Glycine betaine
C2U47_15020	COG4176	ABC-type proline glycine betaine transport system permease component
C2U47_15025	COG2113	Glycine betaine
C2U47_15030	COG0175	sulfate reduction
C2U47_15035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_15050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U47_15065	COG0786	glutamate:sodium symporter activity
C2U47_15070	COG0252	asparaginase activity
C2U47_15075	COG3139	Protein of unknown function (DUF1315)
C2U47_15095	COG0616	signal peptide processing
C2U47_15100	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_15100	COG1902	pentaerythritol trinitrate reductase activity
C2U47_15105	COG0778	Nitroreductase
C2U47_15115	COG0110	maltose O-acetyltransferase activity
C2U47_15120	COG2264	protein methyltransferase activity
C2U47_15125	COG0604	alcohol dehydrogenase
C2U47_15130	COG0583	DNA-binding transcription factor activity
C2U47_15135	COG1263	PTS System
C2U47_15135	COG2190	(PTS) system
C2U47_15135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_15140	COG4145	pantothenate transmembrane transporter activity
C2U47_15145	COG3924	membrane
C2U47_15150	COG0439	Biotin carboxylase
C2U47_15155	COG0511	ligase activity, forming carbon-carbon bonds
C2U47_15160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U47_15165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U47_15180	COG3381	protein complex oligomerization
C2U47_15195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U47_15205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U47_15210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U47_15210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U47_15225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U47_15230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_15235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U47_15240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U47_15245	COG4172	Belongs to the ABC transporter superfamily
C2U47_15265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U47_15270	COG0142	geranyltranstransferase activity
C2U47_15275	COG1722	exodeoxyribonuclease VII activity
C2U47_15280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_15285	COG1360	Flagellar Motor Protein
C2U47_15290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U47_15300	COG1534	Rna-binding protein
C2U47_15305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U47_15310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U47_15315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U47_15320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U47_15325	COG0149	triose-phosphate isomerase activity
C2U47_15330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U47_15345	COG0779	Required for maturation of 30S ribosomal subunits
C2U47_15350	COG0195	Participates in both transcription termination and antitermination
C2U47_15355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U47_15360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U47_15365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U47_15370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U47_15375	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U47_15380	COG2211	Major facilitator Superfamily
C2U47_15385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U47_15390	COG1422	Protein of unknown function (DUF1090)
C2U47_15405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_15425	COG0312	modulator of DNA gyrase
C2U47_15435	COG0312	modulator of DNA gyrase
C2U47_15440	COG0716	FMN binding
C2U47_15445	COG4974	Belongs to the 'phage' integrase family
C2U47_15450	COG1970	mechanosensitive ion channel activity
C2U47_15460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U47_15465	COG0789	Transcriptional regulator
C2U47_15480	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_15490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U47_15495	COG0321	lipoyl(octanoyl) transferase activity
C2U47_15500	COG2921	Belongs to the UPF0250 family
C2U47_15505	COG1686	Belongs to the peptidase S11 family
C2U47_15510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U47_15515	COG2951	lytic endotransglycosylase activity
C2U47_15520	COG0772	Belongs to the SEDS family
C2U47_15525	COG0768	penicillin binding
C2U47_15530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U47_15535	COG0799	negative regulation of ribosome biogenesis
C2U47_15540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U47_15555	COG0495	leucyl-tRNA aminoacylation
C2U47_15560	COG2888	peptidyl-tyrosine sulfation
C2U47_15565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U47_15570	COG4535	Mg2 and Co2 transporter CorC
C2U47_15575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U47_15580	COG1702	phosphate starvation-inducible protein PhoH
C2U47_15585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U47_15590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_15595	COG1335	isochorismatase
C2U47_15610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_15625	COG3706	GGDEF domain
C2U47_15635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U47_15650	COG1464	Belongs to the NlpA lipoprotein family
C2U47_15655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U47_15660	COG2011	ABC-type metal ion transport system permease component
C2U47_15665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U47_15675	COG0516	GMP reductase activity
C2U47_15680	COG4067	protein conserved in archaea
C2U47_15680	COG0189	ligase activity
C2U47_15690	COG0745	RESPONSE REGULATOR receiver
C2U47_15700	COG0300	oxidoreductase activity
C2U47_15720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_15725	COG3214	Protein conserved in bacteria
C2U47_15740	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U47_15745	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U47_15750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U47_15755	COG1053	succinate dehydrogenase
C2U47_15765	COG0584	glycerophosphoryl diester phosphodiesterase
C2U47_15770	COG1511	domain protein
C2U47_15770	COG3264	Mechanosensitive ion channel
C2U47_15795	COG0583	DNA-binding transcription factor activity
C2U47_15810	COG0583	DNA-binding transcription factor activity
C2U47_15815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U47_15845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U47_15850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U47_15860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U47_15865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U47_15870	COG0546	phosphoglycolate phosphatase activity
C2U47_15875	COG0180	Tryptophanyl-tRNA synthetase
C2U47_15890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U47_15900	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_15915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_15940	COG0471	metal ion transport
C2U47_15940	COG0490	domain, Protein
C2U47_16005	COG3385	transposase activity
C2U47_16055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_16090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_16095	COG3041	Addiction module toxin RelE StbE family
C2U47_16110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U47_16125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_16135	COG0583	DNA-binding transcription factor activity
C2U47_16145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_16150	COG0625	glutathione transferase activity
C2U47_16215	COG3385	transposase activity
C2U47_16240	COG1136	(ABC) transporter
C2U47_16255	COG1309	transcriptional regulator
C2U47_16265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_16270	COG1196	nuclear chromosome segregation
C2U47_16300	COG0582	viral genome integration into host DNA
C2U47_16305	COG0012	GTP binding
C2U47_16310	COG0193	aminoacyl-tRNA hydrolase activity
C2U47_16315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U47_16325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U47_16330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U47_16335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U47_16340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U47_16355	COG2912	Transglutaminase-like superfamily
C2U47_16360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U47_16365	COG1301	dicarboxylic acid transport
C2U47_16375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U47_16390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U47_16395	COG1115	amino acid carrier protein
C2U47_16415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U47_16420	COG1678	Uncharacterized ACR, COG1678
C2U47_16425	COG0189	ligase activity
C2U47_16430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U47_16440	COG3091	SprT-like family
C2U47_16450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U47_16475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U47_16480	COG0739	heme binding
C2U47_16485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U47_16495	COG1881	PFAM PEBP family protein
C2U47_16505	COG0583	DNA-binding transcription factor activity
C2U47_16515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U47_16525	COG0583	DNA-binding transcription factor activity
C2U47_16530	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_16535	COG0616	signal peptide processing
C2U47_16540	COG3724	N-succinylarginine dihydrolase activity
C2U47_16545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U47_16555	COG0840	transmembrane signaling receptor activity
C2U47_16565	COG2971	BadF BadG BcrA BcrD
C2U47_16575	COG4608	Belongs to the ABC transporter superfamily
C2U47_16585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_16600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U47_16660	COG0745	RESPONSE REGULATOR receiver
C2U47_16665	COG5002	protein histidine kinase activity
C2U47_16690	COG2132	Multicopper oxidase
C2U47_16705	COG3039	Transposase
C2U47_16715	COG3385	transposase activity
C2U47_16725	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_16740	COG1484	DNA-dependent DNA replication
C2U47_16745	COG4584	PFAM Integrase catalytic
C2U47_16780	COG1484	DNA-dependent DNA replication
C2U47_16820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_16830	COG0732	type I restriction modification DNA specificity domain
C2U47_16855	COG3039	Transposase
C2U47_16875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U47_16890	COG0758	DNA mediated transformation
C2U47_16895	COG0514	ATP-dependent DNA helicase (RecQ)
C2U47_16945	COG3039	Transposase
C2U47_16965	COG5001	Diguanylate cyclase
C2U47_16965	COG3447	MASE1 domain protein
C2U47_16965	COG5002	protein histidine kinase activity
C2U47_16995	COG0640	Transcriptional regulator
C2U47_17000	COG0798	PFAM Bile acid sodium symporter
C2U47_17005	COG1393	Belongs to the ArsC family
C2U47_17015	COG1677	Flagellar hook-basal body complex protein FliE
C2U47_17025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U47_17075	COG1987	bacterial-type flagellum assembly
C2U47_17080	COG1684	flagellar biosynthetic protein fliR
C2U47_17090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U47_17100	COG0455	bacterial-type flagellum organization
C2U47_17115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U47_17120	COG0643	Histidine kinase
C2U47_17120	COG2198	Histidine kinase
C2U47_17130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_17135	COG1360	Flagellar Motor Protein
C2U47_17140	COG1192	Involved in chromosome partitioning
C2U47_17150	COG0835	chemotaxis
C2U47_17165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_17170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_17175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_17180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U47_17185	COG1138	Cytochrome C-type biogenesis protein
C2U47_17190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_17200	COG0457	Tetratricopeptide repeat
C2U47_17215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U47_17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_17220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_17235	COG0259	pyridoxamine-phosphate oxidase activity
C2U47_17265	COG3153	acetyltransferase
C2U47_17280	COG0800	Aldolase
C2U47_17285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_17300	COG0246	Mannitol dehydrogenase
C2U47_17360	COG3039	Transposase
C2U47_17395	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_17415	COG2850	peptidyl-arginine hydroxylation
C2U47_17440	COG0210	DNA helicase
C2U47_17470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U47_17475	COG2867	negative regulation of translational initiation
C2U47_17485	COG0702	epimerase
C2U47_17490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_17495	COG1454	alcohol dehydrogenase
C2U47_17500	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U47_17510	COG1957	nucleoside hydrolase
C2U47_17535	COG1280	lysine exporter protein (LysE YggA)
C2U47_17545	COG3263	regulation of cellular component size
C2U47_17555	COG1876	peptidase activity
C2U47_17560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U47_17565	COG1393	Belongs to the ArsC family
C2U47_17575	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U47_17580	COG1473	amidohydrolase
C2U47_17590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U47_17595	COG0017	Asparaginyl-tRNA synthetase
C2U47_17615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U47_17620	COG0156	8-amino-7-oxononanoate synthase activity
C2U47_17625	COG2226	methyltransferase
C2U47_17625	COG1073	alpha beta
C2U47_17630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U47_17635	COG0501	Belongs to the peptidase M48B family
C2U47_17650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U47_17650	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U47_17650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U47_17650	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U47_17655	COG2841	Protein conserved in bacteria
C2U47_17665	COG0534	Mate efflux family protein
C2U47_17690	COG1454	alcohol dehydrogenase
C2U47_17700	COG1309	transcriptional regulator
C2U47_17715	COG0791	NLP P60 protein
C2U47_17720	COG0583	DNA-binding transcription factor activity
C2U47_17740	COG0500	methyltransferase
C2U47_17745	COG4106	trans-aconitate 2-methyltransferase activity
C2U47_17750	COG1801	Protein of unknown function DUF72
C2U47_17760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U47_17765	COG0217	transcriptional regulatory protein
C2U47_17770	COG2194	sulfuric ester hydrolase activity
C2U47_17775	COG1940	carbohydrate kinase activity
C2U47_17775	COG1846	Transcriptional regulator
C2U47_17780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U47_17785	COG0363	glucosamine-6-phosphate deaminase activity
C2U47_17790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_17790	COG2190	(PTS) system
C2U47_17790	COG1263	PTS System
C2U47_17800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_17805	COG0735	belongs to the Fur family
C2U47_17815	COG0716	FMN binding
C2U47_17830	COG0596	Alpha beta hydrolase
C2U47_17835	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U47_17840	COG0033	Phosphoglucomutase
C2U47_17850	COG1846	Transcriptional regulator
C2U47_17855	COG2951	lytic endotransglycosylase activity
C2U47_17860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U47_17875	COG4134	Bacterial extracellular solute-binding protein
C2U47_17885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U47_17900	COG3039	Transposase
C2U47_17905	COG3039	Transposase
C2U47_17910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U47_17920	COG0729	surface antigen
C2U47_17945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U47_17955	COG0741	lytic transglycosylase activity
C2U47_17970	COG1607	acyl-coa hydrolase
C2U47_17980	COG3021	interspecies interaction between organisms
C2U47_17985	COG1388	LysM domain
C2U47_17985	COG0741	lytic transglycosylase activity
C2U47_17990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U47_17995	COG2226	methyltransferase
C2U47_18000	COG0328	RNA-DNA hybrid ribonuclease activity
C2U47_18005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_18025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U47_18030	COG0121	glutamine amidotransferase
C2U47_18040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U47_18050	COG2205	protein histidine kinase activity
C2U47_18050	COG0784	Response regulator, receiver
C2U47_18065	COG2197	response regulator
C2U47_18070	COG3850	Histidine kinase
C2U47_18075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U47_18080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_18080	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_18090	COG0243	molybdopterin cofactor binding
C2U47_18095	COG0437	4 iron, 4 sulfur cluster binding
C2U47_18110	COG3005	denitrification pathway
C2U47_18115	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U47_18120	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U47_18125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U47_18130	COG0314	molybdopterin synthase activity
C2U47_18145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U47_18150	COG2267	carboxylic ester hydrolase activity
C2U47_18155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U47_18160	COG0303	'Molybdopterin
C2U47_18165	COG0302	gtp cyclohydrolase
C2U47_18170	COG0840	transmembrane signaling receptor activity
C2U47_18175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U47_18185	COG0583	DNA-binding transcription factor activity
C2U47_18215	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U47_18225	COG1166	arginine decarboxylase activity
C2U47_18255	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2U47_18280	COG3385	transposase activity
C2U47_18295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U47_18300	COG1187	pseudouridine synthase activity
C2U47_18315	COG0583	DNA-binding transcription factor activity
C2U47_18335	COG2979	Protein of unknown function (DUF533)
C2U47_18345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_18355	COG1294	oxidase, subunit
C2U47_18365	COG2814	Major facilitator Superfamily
C2U47_18370	COG0656	L-ascorbic acid biosynthetic process
C2U47_18390	COG0583	DNA-binding transcription factor activity
C2U47_18395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U47_18400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U47_18405	COG2271	Major facilitator Superfamily
C2U47_18410	COG1349	DNA-binding transcription factor activity
C2U47_18420	COG0584	glycerophosphoryl diester phosphodiesterase
C2U47_18425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_18430	COG0287	Prephenate dehydrogenase
C2U47_18430	COG1605	Chorismate mutase
C2U47_18440	COG3085	chromosome segregation
C2U47_18445	COG4574	serine-type endopeptidase inhibitor activity
C2U47_18465	COG1770	oligopeptidase
C2U47_18470	COG4771	TonB-dependent receptor
C2U47_18475	COG3083	sulfuric ester hydrolase activity
C2U47_18480	COG3082	Protein of unknown function (DUF1414)
C2U47_18485	COG3081	Nucleoid-associated protein
C2U47_18495	COG1175	transmembrane transport
C2U47_18505	COG3842	ATPase activity
C2U47_18515	COG0596	Alpha beta hydrolase
C2U47_18520	COG3385	transposase activity
C2U47_18535	COG0425	Belongs to the sulfur carrier protein TusA family
C2U47_18540	COG4783	chaperone-mediated protein folding
C2U47_18550	COG1393	Belongs to the ArsC family
C2U47_18565	COG0675	Transposase, IS605 OrfB family
C2U47_18575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_18580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U47_18585	COG2431	L-lysine efflux transmembrane transporter activity
C2U47_18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_18600	COG4215	(ABC) transporter
C2U47_18605	COG4160	amino acid transport
C2U47_18615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U47_18625	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_18630	COG2373	Large extracellular alpha-helical protein
C2U47_18635	COG4953	penicillin-binding protein 1C
C2U47_18645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_18645	COG0301	tRNA thio-modification
C2U47_18660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U47_18665	COG1334	flagellar protein FlaG
C2U47_18700	COG2089	acid synthase
C2U47_18710	COG1083	cytidylyl-transferase
C2U47_18745	COG1216	Glycosyl transferase, family 2
C2U47_18800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U47_18810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U47_18815	COG1086	Polysaccharide biosynthesis protein
C2U47_18820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_18830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U47_18850	COG0675	Transposase, IS605 OrfB family
C2U47_18860	COG0346	lactoylglutathione lyase activity
C2U47_18875	COG4659	FMN binding
C2U47_18880	COG4658	electron transport chain
C2U47_18890	COG2878	Part of a membrane complex involved in electron transport
C2U47_18895	COG4657	Part of a membrane complex involved in electron transport
C2U47_18900	COG0675	Transposase, IS605 OrfB family
C2U47_18905	COG5433	transposase activity
C2U47_18910	COG3039	Transposase
C2U47_18955	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U47_18960	COG1288	antiporter activity
C2U47_18965	COG0436	Aminotransferase
C2U47_18975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U47_18985	COG1061	Type III restriction enzyme res subunit
C2U47_18990	COG1566	PFAM secretion protein HlyD family protein
C2U47_19005	COG0675	Transposase, IS605 OrfB family
C2U47_19015	COG1966	Carbon starvation protein
C2U47_19020	COG3279	Response regulator of the LytR AlgR family
C2U47_19035	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_19035	COG1454	alcohol dehydrogenase
C2U47_19040	COG2095	MarC family integral membrane protein
C2U47_19055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_19060	COG0444	Belongs to the ABC transporter superfamily
C2U47_19070	COG0861	Integral membrane protein TerC family
C2U47_19075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_19085	COG1301	dicarboxylic acid transport
C2U47_19105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U47_19120	COG0537	adenosine 5'-monophosphoramidase activity
C2U47_19155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_19160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_19175	COG2354	Protein conserved in bacteria
C2U47_19180	COG1164	Oligoendopeptidase f
C2U47_19185	COG1164	Oligoendopeptidase f
C2U47_19195	COG1252	NADH dehydrogenase
C2U47_19200	COG0393	Putative heavy-metal-binding
C2U47_19215	COG0527	aspartate kinase activity
C2U47_19220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U47_19220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U47_19225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_19250	COG0583	DNA-binding transcription factor activity
C2U47_19255	COG1620	l-lactate permease
C2U47_19260	COG0247	lactate metabolic process
C2U47_19285	COG3039	Transposase
C2U47_19305	COG1136	(ABC) transporter
C2U47_19325	COG2814	Major facilitator Superfamily
C2U47_19350	COG0672	)-iron permease
C2U47_19385	COG2308	Evidence 4 Homologs of previously reported genes of
C2U47_19420	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_19435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_19440	COG3039	Transposase
C2U47_19445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U47_19455	COG0326	Molecular chaperone. Has ATPase activity
C2U47_19460	COG0563	adenylate kinase activity
C2U47_19465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U47_19470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U47_19475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_19480	COG0840	transmembrane signaling receptor activity
C2U47_19520	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U47_19525	COG1535	isochorismatase
C2U47_19525	COG3433	isochorismatase activity
C2U47_19530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U47_19535	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_19550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_19555	COG2977	Belongs to the P-Pant transferase superfamily
C2U47_19565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_19570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_19575	COG4771	TonB-dependent receptor
C2U47_19595	COG0598	Magnesium transport protein CorA
C2U47_19615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U47_19620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U47_19625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_19630	COG0861	Integral membrane protein TerC family
C2U47_19645	COG1022	Amp-dependent synthetase and ligase
C2U47_19650	COG0295	cytidine deaminase activity
C2U47_19655	COG1346	cytolysis
C2U47_19660	COG1380	Effector of murein hydrolase LrgA
C2U47_19665	COG3345	alpha-galactosidase
C2U47_19675	COG2925	Exonuclease
C2U47_19680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U47_19700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_19705	COG0436	Aminotransferase
C2U47_19710	COG0583	DNA-binding transcription factor activity
C2U47_19715	COG2160	L-arabinose isomerase activity
C2U47_19725	COG1069	ribulokinase activity
C2U47_19730	COG1879	ABC-type sugar transport system periplasmic component
C2U47_19740	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_19750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U47_19755	COG0254	rRNA binding
C2U47_19770	COG1451	nucleotide metabolic process
C2U47_19785	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U47_19795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_19795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U47_19800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U47_19820	COG2009	succinate dehydrogenase
C2U47_19825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U47_19840	COG0567	Dehydrogenase, E1 component
C2U47_19845	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U47_19850	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U47_19855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U47_19860	COG2801	Transposase and inactivated derivatives
C2U47_19875	COG2983	Belongs to the UPF0260 family
C2U47_19885	COG1882	Formate acetyltransferase
C2U47_19890	COG2116	formate transmembrane transporter activity
C2U47_19895	COG1944	ATP diphosphatase activity
C2U47_19905	COG2076	Multidrug Resistance protein
C2U47_19910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U47_19915	COG1278	Cold shock
C2U47_19920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U47_19925	COG0542	response to heat
C2U47_19930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U47_19935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U47_19940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U47_19945	COG3134	Outer membrane lipoprotein
C2U47_19950	COG3706	GGDEF domain
C2U47_19955	COG0492	ferredoxin-NADP+ reductase activity
C2U47_19960	COG0686	Belongs to the AlaDH PNT family
C2U47_19970	COG0531	amino acid
C2U47_19970	COG1674	ftsk spoiiie
C2U47_19975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U47_19980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U47_19985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U47_19990	COG1286	toxin biosynthetic process
C2U47_19995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U47_20000	COG2723	6-phospho-beta-galactosidase activity
C2U47_20005	COG1263	PTS System
C2U47_20005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_20010	COG1609	Transcriptional regulator
C2U47_20020	COG4172	Belongs to the ABC transporter superfamily
C2U47_20030	COG4171	peptide transport system, permease
C2U47_20035	COG4168	peptide transport system, permease
C2U47_20045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U47_20050	COG1842	Phage shock protein A
C2U47_20065	COG3106	COG3106 Predicted ATPase
C2U47_20070	COG3768	UPF0283 membrane protein
C2U47_20080	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U47_20095	COG2199	diguanylate cyclase activity
C2U47_20100	COG2885	chlorophyll binding
C2U47_20110	COG1570	exodeoxyribonuclease VII activity
C2U47_20130	COG0516	GMP reductase activity
C2U47_20130	COG0517	IMP dehydrogenase activity
C2U47_20135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U47_20135	COG0519	Catalyzes the synthesis of GMP from XMP
C2U47_20140	COG3039	Transposase
C2U47_20170	COG1846	Transcriptional regulator
C2U47_20190	COG2062	phosphohistidine phosphatase, SixA
C2U47_20200	COG0697	spore germination
C2U47_20210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U47_20215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U47_20225	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U47_20230	COG1136	(ABC) transporter
C2U47_20235	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U47_20240	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U47_20255	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U47_20260	COG0740	serine-type endopeptidase activity
C2U47_20265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U47_20270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U47_20275	COG0776	regulation of translation
C2U47_20280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U47_20285	COG0488	(ABC) transporter
C2U47_20290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U47_20295	COG3162	membrane
C2U47_20310	COG1024	Enoyl-CoA hydratase
C2U47_20315	COG1115	amino acid carrier protein
C2U47_20325	COG3228	Belongs to the MtfA family
C2U47_20330	COG1584	GPR1 FUN34 yaaH family protein
C2U47_20355	COG1024	Enoyl-CoA hydratase
C2U47_20360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U47_20365	COG1960	acyl-CoA dehydrogenase activity
C2U47_20375	COG1960	acyl-CoA dehydrogenase activity
C2U47_20380	COG1024	Enoyl-CoA hydratase
C2U47_20385	COG1024	Enoyl-CoA hydratase
C2U47_20395	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_20405	COG0730	response to heat
C2U47_20435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_20475	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_20480	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_20485	COG1129	ABC transporter
C2U47_20490	COG1879	ABC-type sugar transport system periplasmic component
C2U47_20495	COG0583	DNA-binding transcription factor activity
C2U47_20510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U47_20515	COG0243	molybdopterin cofactor binding
C2U47_20520	COG0745	RESPONSE REGULATOR receiver
C2U47_20520	COG3706	GGDEF domain
C2U47_20525	COG0583	DNA-binding transcription factor activity
C2U47_20530	COG2723	6-phospho-beta-galactosidase activity
C2U47_20540	COG0583	DNA-binding transcription factor activity
C2U47_20555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U47_20560	COG0673	inositol 2-dehydrogenase activity
C2U47_20565	COG0583	DNA-binding transcription factor activity
C2U47_20575	COG1560	Kdo2-lipid A biosynthetic process
C2U47_20580	COG1560	Kdo2-lipid A biosynthetic process
C2U47_20595	COG0417	DNA replication proofreading
C2U47_20625	COG0534	Mate efflux family protein
C2U47_20635	COG0307	riboflavin synthase, alpha
C2U47_20650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_20655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U47_20660	COG0697	spore germination
C2U47_20665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U47_20695	COG0675	Transposase, IS605 OrfB family
C2U47_20700	COG2996	Protein conserved in bacteria
C2U47_20720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U47_20730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U47_20735	COG2894	cell division
C2U47_20740	COG0850	regulation of cytokinetic process
C2U47_20745	COG3100	YcgL domain-containing protein
C2U47_20750	COG2951	lytic endotransglycosylase activity
C2U47_20755	COG1760	l-serine dehydratase
C2U47_20765	COG1760	l-serine dehydratase
C2U47_20770	COG3123	guanosine phosphorylase activity
C2U47_20775	COG1301	dicarboxylic acid transport
C2U47_20790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U47_20795	COG2067	long-chain fatty acid transport protein
C2U47_20800	COG2067	long-chain fatty acid transport protein
C2U47_20810	COG1595	DNA-templated transcription, initiation
C2U47_20840	COG0714	Associated with various cellular activities
C2U47_20845	COG0183	Belongs to the thiolase family
C2U47_20860	COG4681	YaeQ
C2U47_20880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_20895	COG3134	Outer membrane lipoprotein
C2U47_20900	COG0318	PFAM AMP-dependent synthetase and ligase
C2U47_20920	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U47_20920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U47_20925	COG0107	imidazoleglycerol-phosphate synthase activity
C2U47_20940	COG3437	response regulator, receiver
C2U47_20945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U47_20950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U47_20955	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U47_20955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U47_20960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U47_20965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U47_20970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U47_20985	COG1214	PFAM Peptidase M22, glycoprotease
C2U47_20995	COG0596	Alpha beta hydrolase
C2U47_21000	COG0318	PFAM AMP-dependent synthetase and ligase
C2U47_21025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U47_21030	COG2832	Protein of unknown function (DUF454)
C2U47_21035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U47_21045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U47_21050	COG0583	DNA-binding transcription factor activity
C2U47_21065	COG2197	response regulator
C2U47_21075	COG1643	Atp-dependent helicase
C2U47_21085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U47_21100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U47_21105	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U47_21110	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U47_21125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U47_21130	COG0840	transmembrane signaling receptor activity
C2U47_21135	COG1254	Belongs to the acylphosphatase family
C2U47_21145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_21145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_21150	COG0489	protein tyrosine kinase activity
C2U47_21155	COG0572	uridine kinase
C2U47_21160	COG0717	Belongs to the dCTP deaminase family
C2U47_21165	COG0306	phosphate transporter
C2U47_21170	COG1530	ribonuclease E activity
C2U47_21175	COG0564	pseudouridine synthase activity
C2U47_21190	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U47_21195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U47_21200	COG0416	fatty acid biosynthetic process
C2U47_21205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U47_21215	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_21220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U47_21225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U47_21230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U47_21235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U47_21240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U47_21245	COG0470	DNA polymerase III
C2U47_21250	COG0084	hydrolase, TatD family'
C2U47_21265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U47_21265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_21270	COG3008	intermembrane lipid transfer
C2U47_21275	COG2995	paraquat-inducible protein a
C2U47_21285	COG3141	response to X-ray
C2U47_21295	COG1067	ATP-dependent peptidase activity
C2U47_21300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U47_21325	COG0116	Belongs to the methyltransferase superfamily
C2U47_21325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U47_21335	COG0167	dihydroorotate dehydrogenase activity
C2U47_21350	COG0308	aminopeptidase N
C2U47_21360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U47_21365	COG1956	GAF domain-containing protein
C2U47_21375	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U47_21390	COG2010	Cytochrome c
C2U47_21400	COG2217	Heavy metal translocating P-type atpase
C2U47_21415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U47_21420	COG0589	response to stress
C2U47_21425	COG0037	tRNA processing
C2U47_21440	COG0625	glutathione transferase activity
C2U47_21445	COG1869	D-ribose catabolic process
C2U47_21450	COG1129	ABC transporter
C2U47_21455	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_21460	COG1879	ABC-type sugar transport system periplasmic component
C2U47_21465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_21470	COG1609	Transcriptional regulator
C2U47_21495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U47_21515	COG0776	regulation of translation
C2U47_21520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_21520	COG0072	phenylalanine-tRNA ligase activity
C2U47_21525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U47_21530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U47_21535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U47_21540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U47_21545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U47_21570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_21580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_21585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_21590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_21595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U47_21600	COG3313	Fe-S protein
C2U47_21605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U47_21605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U47_21605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U47_21610	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U47_21615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_21615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_21620	COG1609	Transcriptional regulator
C2U47_21625	COG0814	amino acid
C2U47_21635	COG5654	RES domain protein
C2U47_21645	COG0513	Belongs to the DEAD box helicase family
C2U47_21655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U47_21660	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U47_21665	COG2840	Smr protein MutS2
C2U47_21700	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U47_21765	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U47_21770	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U47_21780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_21785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U47_21795	COG0205	6-phosphofructokinase activity
C2U47_21810	COG1473	amidohydrolase
C2U47_21815	COG1011	Hydrolase
C2U47_21820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U47_21860	COG3593	DNA synthesis involved in DNA repair
C2U47_21875	COG0583	DNA-binding transcription factor activity
C2U47_21880	COG0730	response to heat
C2U47_21890	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U47_21900	COG0386	Belongs to the glutathione peroxidase family
C2U47_21905	COG0513	Belongs to the DEAD box helicase family
C2U47_21940	COG2329	Antibiotic biosynthesis monooxygenase
C2U47_21945	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U47_21965	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U47_21975	COG2501	S4 domain
C2U47_21995	COG1132	(ABC) transporter
C2U47_22010	COG3118	belongs to the thioredoxin family
C2U47_22015	COG0471	metal ion transport
C2U47_22030	COG0058	SHG alpha-glucan phosphorylase activity
C2U47_22060	COG0814	amino acid
C2U47_22065	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U47_22085	COG2766	serine protein kinase
C2U47_22090	COG2718	Belongs to the UPF0229 family
C2U47_22095	COG2719	SpoVR family
C2U47_22100	COG2186	Transcriptional regulator
C2U47_22105	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U47_22110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U47_22115	COG0586	Pfam SNARE associated Golgi protein
C2U47_22125	COG0556	nucleotide-excision repair
C2U47_22140	COG0569	domain protein
C2U47_22140	COG2985	domain, Protein
C2U47_22145	COG1196	nuclear chromosome segregation
C2U47_22145	COG0741	lytic transglycosylase activity
C2U47_22145	COG0739	heme binding
C2U47_22150	COG3181	Tripartite tricarboxylate transporter family receptor
C2U47_22165	COG4565	transcriptional regulatory protein
C2U47_22170	COG3290	protein histidine kinase activity
C2U47_22175	COG1940	carbohydrate kinase activity
C2U47_22175	COG1846	Transcriptional regulator
C2U47_22180	COG0840	transmembrane signaling receptor activity
C2U47_22185	COG3012	SEC-C Motif Domain Protein
C2U47_22190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U47_22195	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U47_22210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U47_22215	COG0437	4 iron, 4 sulfur cluster binding
C2U47_22225	COG1138	Cytochrome C-type biogenesis protein
C2U47_22230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_22235	COG3088	subunit of a heme lyase
C2U47_22235	COG4235	cytochrome complex assembly
C2U47_22250	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U47_22255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_22270	COG0516	GMP reductase activity
C2U47_22270	COG0517	IMP dehydrogenase activity
C2U47_22280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U47_22285	COG0583	DNA-binding transcription factor activity
C2U47_22300	COG2203	Gaf domain
C2U47_22300	COG2199	diguanylate cyclase activity
C2U47_22305	COG2200	EAL domain
C2U47_22310	COG4977	sequence-specific DNA binding
C2U47_22310	COG1917	Cupin 2, conserved barrel domain protein
C2U47_22315	COG0583	DNA-binding transcription factor activity
C2U47_22320	COG2910	NAD(P)H-binding
C2U47_22330	COG0626	cystathionine gamma-synthase activity
C2U47_22335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U47_22355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U47_22370	COG2723	6-phospho-beta-galactosidase activity
C2U47_22375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_22375	COG2190	(PTS) system
C2U47_22375	COG1263	PTS System
C2U47_22380	COG1737	Transcriptional regulator
C2U47_22405	COG1435	thymidine kinase activity
C2U47_22410	COG1757	Na H antiporter
C2U47_22415	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_22420	COG2096	Adenosyltransferase
C2U47_22425	COG3530	Putative quorum-sensing-regulated virulence factor
C2U47_22430	COG0602	queuosine metabolic process
C2U47_22435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U47_22455	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U47_22465	COG0776	regulation of translation
C2U47_22470	COG0539	negative regulation of cytoplasmic translation
C2U47_22475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U47_22480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U47_22510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U47_22545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_22565	COG1280	lysine exporter protein (LysE YggA)
C2U47_22605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U47_22630	COG3093	addiction module antidote protein HigA
C2U47_22725	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C2U47_22740	COG3736	Type IV secretory pathway, component VirB8
C2U47_22765	COG3451	type IV secretory pathway VirB4