locus-tag	class	description
I6L36_00010	COG0713	ATP synthesis coupled electron transport
I6L36_00015	COG0839	Belongs to the complex I subunit 6 family
I6L36_00020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L36_00025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L36_00030	COG1034	ATP synthesis coupled electron transport
I6L36_00045	COG0649	NAD binding
I6L36_00045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L36_00050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L36_00055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L36_00060	COG1360	Flagellar Motor Protein
I6L36_00065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L36_00085	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L36_00105	COG0724	RNA recognition motif
I6L36_00110	COG4989	oxidoreductase activity
I6L36_00135	COG0745	RESPONSE REGULATOR receiver
I6L36_00140	COG0583	DNA-binding transcription factor activity
I6L36_00150	COG3300	MHYT domain
I6L36_00150	COG5001	Diguanylate cyclase
I6L36_00155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L36_00185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L36_00190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L36_00195	COG0539	negative regulation of cytoplasmic translation
I6L36_00200	COG0776	regulation of translation
I6L36_00210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L36_00230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L36_00235	COG0602	queuosine metabolic process
I6L36_00240	COG3530	Putative quorum-sensing-regulated virulence factor
I6L36_00245	COG2096	Adenosyltransferase
I6L36_00250	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L36_00255	COG1757	Na H antiporter
I6L36_00260	COG1435	thymidine kinase activity
I6L36_00280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6L36_00295	COG1349	DNA-binding transcription factor activity
I6L36_00300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6L36_00310	COG3550	peptidyl-serine autophosphorylation
I6L36_00415	COG0745	RESPONSE REGULATOR receiver
I6L36_00420	COG2205	protein histidine kinase activity
I6L36_00420	COG2198	Histidine kinase
I6L36_00420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_00420	COG0784	Response regulator, receiver
I6L36_00445	COG0411	ABC transporter
I6L36_00455	COG0829	nickel cation binding
I6L36_00460	COG0831	urea catabolic process
I6L36_00465	COG0832	Belongs to the urease beta subunit family
I6L36_00470	COG0804	urea catabolic process
I6L36_00475	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6L36_00485	COG0830	nickel cation binding
I6L36_00490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L36_00570	COG3039	Transposase
I6L36_00615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L36_00660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L36_00665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L36_00670	COG1397	ADP-ribosylglycohydrolase
I6L36_00750	COG2226	methyltransferase
I6L36_00780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L36_00785	COG0626	cystathionine gamma-synthase activity
I6L36_00795	COG2910	NAD(P)H-binding
I6L36_00800	COG0583	DNA-binding transcription factor activity
I6L36_00805	COG1917	Cupin 2, conserved barrel domain protein
I6L36_00805	COG4977	sequence-specific DNA binding
I6L36_00810	COG2200	EAL domain
I6L36_00810	COG2771	luxR family
I6L36_00820	COG4774	siderophore transport
I6L36_00830	COG0583	DNA-binding transcription factor activity
I6L36_00835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L36_00845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L36_00845	COG0617	tRNA 3'-terminal CCA addition
I6L36_00845	COG0517	IMP dehydrogenase activity
I6L36_00860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L36_00865	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L36_00880	COG4235	cytochrome complex assembly
I6L36_00880	COG3088	subunit of a heme lyase
I6L36_00885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L36_00890	COG1138	Cytochrome C-type biogenesis protein
I6L36_00895	COG3301	Polysulphide reductase, NrfD
I6L36_00900	COG0437	4 iron, 4 sulfur cluster binding
I6L36_00905	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L36_00920	COG0247	lactate metabolic process
I6L36_00930	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L36_00935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L36_00940	COG3012	SEC-C Motif Domain Protein
I6L36_00945	COG0840	transmembrane signaling receptor activity
I6L36_00950	COG1846	Transcriptional regulator
I6L36_00950	COG1940	carbohydrate kinase activity
I6L36_00955	COG3290	protein histidine kinase activity
I6L36_00960	COG4565	transcriptional regulatory protein
I6L36_00975	COG3181	Tripartite tricarboxylate transporter family receptor
I6L36_00980	COG0739	heme binding
I6L36_00980	COG0741	lytic transglycosylase activity
I6L36_00980	COG1196	nuclear chromosome segregation
I6L36_00985	COG2985	domain, Protein
I6L36_00985	COG0569	domain protein
I6L36_00995	COG0556	nucleotide-excision repair
I6L36_01005	COG0586	Pfam SNARE associated Golgi protein
I6L36_01010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L36_01015	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L36_01020	COG2186	Transcriptional regulator
I6L36_01030	COG2719	SpoVR family
I6L36_01035	COG2718	Belongs to the UPF0229 family
I6L36_01040	COG2766	serine protein kinase
I6L36_01045	COG0514	ATP-dependent DNA helicase (RecQ)
I6L36_01050	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L36_01055	COG0814	amino acid
I6L36_01090	COG0058	SHG alpha-glucan phosphorylase activity
I6L36_01100	COG0471	metal ion transport
I6L36_01105	COG3118	belongs to the thioredoxin family
I6L36_01115	COG1132	(ABC) transporter
I6L36_01120	COG1132	(ABC) transporter
I6L36_01140	COG2501	S4 domain
I6L36_01170	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L36_01175	COG2329	Antibiotic biosynthesis monooxygenase
I6L36_01200	COG0513	Belongs to the DEAD box helicase family
I6L36_01205	COG0386	Belongs to the glutathione peroxidase family
I6L36_01215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L36_01220	COG3148	PFAM DTW domain containing protein
I6L36_01230	COG0730	response to heat
I6L36_01235	COG0583	DNA-binding transcription factor activity
I6L36_01250	COG3593	DNA synthesis involved in DNA repair
I6L36_01290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L36_01295	COG1011	Hydrolase
I6L36_01300	COG1473	amidohydrolase
I6L36_01305	COG0205	6-phosphofructokinase activity
I6L36_01315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L36_01320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L36_01330	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L36_01335	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L36_01360	COG0588	phosphoglycerate mutase activity
I6L36_01370	COG0675	Transposase, IS605 OrfB family
I6L36_01385	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L36_01420	COG2840	Smr protein MutS2
I6L36_01425	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L36_01430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L36_01440	COG0513	Belongs to the DEAD box helicase family
I6L36_01445	COG5654	RES domain protein
I6L36_01455	COG0814	amino acid
I6L36_01460	COG1609	Transcriptional regulator
I6L36_01465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_01465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_01470	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L36_01475	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L36_01475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L36_01475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L36_01480	COG3313	Fe-S protein
I6L36_01485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L36_01490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L36_01495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L36_01500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L36_01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L36_01535	COG0675	Transposase, IS605 OrfB family
I6L36_01565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L36_01570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L36_01575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L36_01580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L36_01585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L36_01590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L36_01590	COG0072	phenylalanine-tRNA ligase activity
I6L36_01595	COG0776	regulation of translation
I6L36_01630	COG1609	Transcriptional regulator
I6L36_01635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L36_01640	COG1879	ABC-type sugar transport system periplasmic component
I6L36_01645	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L36_01695	COG1869	D-ribose catabolic process
I6L36_01700	COG0625	glutathione transferase activity
I6L36_01715	COG0037	tRNA processing
I6L36_01720	COG0589	response to stress
I6L36_01725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L36_01740	COG2217	Heavy metal translocating P-type atpase
I6L36_01750	COG2010	Cytochrome c
I6L36_01765	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L36_01780	COG1956	GAF domain-containing protein
I6L36_01785	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L36_01795	COG0308	aminopeptidase N
I6L36_01805	COG2902	Dehydrogenase
I6L36_01810	COG0167	dihydroorotate dehydrogenase activity
I6L36_01820	COG0116	Belongs to the methyltransferase superfamily
I6L36_01820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L36_01830	COG0488	(ABC) transporter
I6L36_01845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L36_01850	COG1067	ATP-dependent peptidase activity
I6L36_01860	COG3141	response to X-ray
I6L36_01870	COG2995	paraquat-inducible protein a
I6L36_01875	COG3008	intermembrane lipid transfer
I6L36_01880	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L36_01880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L36_01895	COG0084	hydrolase, TatD family'
I6L36_01900	COG0470	DNA polymerase III
I6L36_01905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L36_01910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L36_01915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L36_01920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L36_01925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L36_01930	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_01940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L36_01945	COG0416	fatty acid biosynthetic process
I6L36_01950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L36_01955	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L36_01970	COG0564	pseudouridine synthase activity
I6L36_01975	COG1530	ribonuclease E activity
I6L36_01980	COG0306	phosphate transporter
I6L36_01985	COG0717	Belongs to the dCTP deaminase family
I6L36_01990	COG0572	uridine kinase
I6L36_01995	COG0489	protein tyrosine kinase activity
I6L36_02000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L36_02000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L36_02010	COG1254	Belongs to the acylphosphatase family
I6L36_02015	COG0840	transmembrane signaling receptor activity
I6L36_02020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L36_02035	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L36_02040	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L36_02045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L36_02060	COG0675	Transposase, IS605 OrfB family
I6L36_02075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L36_02085	COG1643	Atp-dependent helicase
I6L36_02090	COG0617	tRNA 3'-terminal CCA addition
I6L36_02090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L36_02090	COG0517	IMP dehydrogenase activity
I6L36_02095	COG2197	response regulator
I6L36_02100	COG3314	Sporulation integral membrane protein YlbJ
I6L36_02110	COG0583	DNA-binding transcription factor activity
I6L36_02115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L36_02125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L36_02130	COG2832	Protein of unknown function (DUF454)
I6L36_02135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L36_02145	COG0697	spore germination
I6L36_02160	COG0318	PFAM AMP-dependent synthetase and ligase
I6L36_02165	COG0596	Alpha beta hydrolase
I6L36_02175	COG1214	PFAM Peptidase M22, glycoprotease
I6L36_02180	COG1199	ATP-dependent helicase activity
I6L36_02190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L36_02195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L36_02200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L36_02205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L36_02205	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L36_02210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L36_02215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L36_02220	COG3437	response regulator, receiver
I6L36_02225	COG2199	diguanylate cyclase activity
I6L36_02230	COG0784	Response regulator, receiver
I6L36_02230	COG2198	Histidine kinase
I6L36_02230	COG2205	protein histidine kinase activity
I6L36_02235	COG0107	imidazoleglycerol-phosphate synthase activity
I6L36_02240	COG0140	phosphoribosyl-ATP diphosphatase activity
I6L36_02240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L36_02250	COG2378	regulation of single-species biofilm formation
I6L36_02255	COG0318	PFAM AMP-dependent synthetase and ligase
I6L36_02260	COG3134	Outer membrane lipoprotein
I6L36_02275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L36_02305	COG4681	YaeQ
I6L36_02315	COG1024	Enoyl-CoA hydratase
I6L36_02315	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L36_02320	COG0183	Belongs to the thiolase family
I6L36_02325	COG0714	Associated with various cellular activities
I6L36_02355	COG1595	DNA-templated transcription, initiation
I6L36_02365	COG2067	long-chain fatty acid transport protein
I6L36_02370	COG2067	long-chain fatty acid transport protein
I6L36_02375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L36_02390	COG1301	dicarboxylic acid transport
I6L36_02395	COG3123	guanosine phosphorylase activity
I6L36_02400	COG1760	l-serine dehydratase
I6L36_02405	COG1760	l-serine dehydratase
I6L36_02415	COG3100	YcgL domain-containing protein
I6L36_02420	COG0850	regulation of cytokinetic process
I6L36_02425	COG2894	cell division
I6L36_02430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L36_02435	COG3099	Belongs to the UPF0263 family
I6L36_02440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L36_02455	COG2996	Protein conserved in bacteria
I6L36_02480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L36_02485	COG0697	spore germination
I6L36_02490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L36_02495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L36_02510	COG0307	riboflavin synthase, alpha
I6L36_02520	COG0534	Mate efflux family protein
I6L36_02550	COG0417	DNA replication proofreading
I6L36_02565	COG1560	Kdo2-lipid A biosynthetic process
I6L36_02570	COG1560	Kdo2-lipid A biosynthetic process
I6L36_02580	COG0583	DNA-binding transcription factor activity
I6L36_02585	COG0673	inositol 2-dehydrogenase activity
I6L36_02590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L36_02605	COG0583	DNA-binding transcription factor activity
I6L36_02615	COG2723	6-phospho-beta-galactosidase activity
I6L36_02620	COG0583	DNA-binding transcription factor activity
I6L36_02630	COG0243	molybdopterin cofactor binding
I6L36_02635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L36_02645	COG1879	ABC-type sugar transport system periplasmic component
I6L36_02650	COG1129	ABC transporter
I6L36_02665	COG0784	Response regulator, receiver
I6L36_02665	COG2205	protein histidine kinase activity
I6L36_02670	COG2197	response regulator
I6L36_02675	COG1012	belongs to the aldehyde dehydrogenase family
I6L36_02680	COG0531	amino acid
I6L36_02705	COG2072	flavoprotein involved in K transport
I6L36_02710	COG0583	DNA-binding transcription factor activity
I6L36_02720	COG0730	response to heat
I6L36_02730	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_02740	COG1024	Enoyl-CoA hydratase
I6L36_02745	COG1024	Enoyl-CoA hydratase
I6L36_02750	COG1960	acyl-CoA dehydrogenase activity
I6L36_02760	COG1960	acyl-CoA dehydrogenase activity
I6L36_02765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L36_02770	COG1024	Enoyl-CoA hydratase
I6L36_02795	COG1584	GPR1 FUN34 yaaH family protein
I6L36_02800	COG3228	Belongs to the MtfA family
I6L36_02810	COG1115	amino acid carrier protein
I6L36_02815	COG1024	Enoyl-CoA hydratase
I6L36_02830	COG3162	membrane
I6L36_02835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L36_02840	COG0488	(ABC) transporter
I6L36_02845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L36_02850	COG0776	regulation of translation
I6L36_02855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L36_02860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L36_02865	COG0740	serine-type endopeptidase activity
I6L36_02870	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L36_02880	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L36_02885	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L36_02890	COG1136	(ABC) transporter
I6L36_02895	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L36_02905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L36_02910	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L36_02925	COG0697	spore germination
I6L36_02935	COG2062	phosphohistidine phosphatase, SixA
I6L36_02955	COG1846	Transcriptional regulator
I6L36_02975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L36_02975	COG0519	Catalyzes the synthesis of GMP from XMP
I6L36_02980	COG0517	IMP dehydrogenase activity
I6L36_02980	COG0516	GMP reductase activity
I6L36_02995	COG0675	Transposase, IS605 OrfB family
I6L36_03025	COG2885	chlorophyll binding
I6L36_03030	COG2199	diguanylate cyclase activity
I6L36_03045	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L36_03055	COG3768	UPF0283 membrane protein
I6L36_03060	COG3106	COG3106 Predicted ATPase
I6L36_03075	COG1842	Phage shock protein A
I6L36_03080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L36_03095	COG4171	peptide transport system, permease
I6L36_03105	COG4172	Belongs to the ABC transporter superfamily
I6L36_03115	COG1609	Transcriptional regulator
I6L36_03120	COG0675	Transposase, IS605 OrfB family
I6L36_03135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L36_03135	COG1263	PTS System
I6L36_03145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L36_03150	COG1286	toxin biosynthetic process
I6L36_03155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L36_03160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L36_03165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L36_03170	COG0531	amino acid
I6L36_03170	COG1674	ftsk spoiiie
I6L36_03180	COG0686	Belongs to the AlaDH PNT family
I6L36_03185	COG0492	ferredoxin-NADP+ reductase activity
I6L36_03200	COG3706	GGDEF domain
I6L36_03205	COG3134	Outer membrane lipoprotein
I6L36_03210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L36_03215	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L36_03220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L36_03225	COG0542	response to heat
I6L36_03230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L36_03235	COG1278	Cold shock
I6L36_03240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L36_03255	COG1944	ATP diphosphatase activity
I6L36_03260	COG2116	formate transmembrane transporter activity
I6L36_03265	COG1882	Formate acetyltransferase
I6L36_03270	COG2983	Belongs to the UPF0260 family
I6L36_03280	COG3385	transposase activity
I6L36_03285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L36_03290	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L36_03295	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L36_03300	COG0567	Dehydrogenase, E1 component
I6L36_03315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L36_03320	COG2009	succinate dehydrogenase
I6L36_03340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L36_03345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L36_03345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L36_03355	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L36_03370	COG1451	nucleotide metabolic process
I6L36_03385	COG0254	rRNA binding
I6L36_03390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L36_03400	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L36_03405	COG1129	ABC transporter
I6L36_03410	COG1879	ABC-type sugar transport system periplasmic component
I6L36_03415	COG1069	ribulokinase activity
I6L36_03425	COG2160	L-arabinose isomerase activity
I6L36_03435	COG0436	Aminotransferase
I6L36_03440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L36_03455	COG0392	lysyltransferase activity
I6L36_03455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6L36_03460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L36_03480	COG2801	Transposase and inactivated derivatives
I6L36_03530	COG2801	Transposase and inactivated derivatives
I6L36_03545	COG3039	Transposase
I6L36_03560	COG2925	Exonuclease
I6L36_03570	COG3345	alpha-galactosidase
I6L36_03575	COG1380	Effector of murein hydrolase LrgA
I6L36_03580	COG1346	cytolysis
I6L36_03585	COG0295	cytidine deaminase activity
I6L36_03590	COG1022	Amp-dependent synthetase and ligase
I6L36_03605	COG0861	Integral membrane protein TerC family
I6L36_03610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L36_03615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L36_03620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L36_03660	COG4771	TonB-dependent receptor
I6L36_03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L36_03670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L36_03675	COG1120	ATPase activity
I6L36_03690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L36_03700	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_03705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L36_03710	COG1535	isochorismatase
I6L36_03710	COG3433	isochorismatase activity
I6L36_03715	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L36_03740	COG3300	MHYT domain
I6L36_03740	COG5001	Diguanylate cyclase
I6L36_03755	COG0840	transmembrane signaling receptor activity
I6L36_03760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L36_03765	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L36_03770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L36_03775	COG0563	adenylate kinase activity
I6L36_03780	COG0326	Molecular chaperone. Has ATPase activity
I6L36_03785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L36_03790	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L36_03795	COG0298	carbon dioxide binding
I6L36_03805	COG0309	Hydrogenase expression formation protein (HypE)
I6L36_03810	COG0375	protein maturation
I6L36_03815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L36_03820	COG1124	(ABC) transporter
I6L36_03830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L36_03845	COG1773	rubredoxin
I6L36_03850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L36_03855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L36_03860	COG5557	Pfam Polysulphide reductase, NrfD
I6L36_03865	COG0437	4 iron, 4 sulfur cluster binding
I6L36_03870	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L36_03875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L36_03950	COG4974	Belongs to the 'phage' integrase family
I6L36_03970	COG0659	secondary active sulfate transmembrane transporter activity
I6L36_04000	COG0672	)-iron permease
I6L36_04020	COG2814	Major facilitator Superfamily
I6L36_04040	COG1136	(ABC) transporter
I6L36_04045	COG0577	efflux transmembrane transporter activity
I6L36_04075	COG1139	Iron-sulfur cluster binding protein
I6L36_04080	COG0247	lactate metabolic process
I6L36_04085	COG1620	l-lactate permease
I6L36_04090	COG0583	DNA-binding transcription factor activity
I6L36_04115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L36_04120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L36_04120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L36_04125	COG0527	aspartate kinase activity
I6L36_04135	COG1368	sulfuric ester hydrolase activity
I6L36_04140	COG0393	Putative heavy-metal-binding
I6L36_04145	COG1252	NADH dehydrogenase
I6L36_04150	COG3150	esterase
I6L36_04155	COG1164	Oligoendopeptidase f
I6L36_04160	COG1164	Oligoendopeptidase f
I6L36_04165	COG2354	Protein conserved in bacteria
I6L36_04180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L36_04185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L36_04220	COG0537	adenosine 5'-monophosphoramidase activity
I6L36_04415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L36_04540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L36_04565	COG0582	viral genome integration into host DNA
I6L36_04570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L36_04590	COG1301	dicarboxylic acid transport
I6L36_04600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L36_04605	COG0861	Integral membrane protein TerC family
I6L36_04615	COG0444	Belongs to the ABC transporter superfamily
I6L36_04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L36_04625	COG0601	transmembrane transport
I6L36_04635	COG2095	MarC family integral membrane protein
I6L36_04640	COG1454	alcohol dehydrogenase
I6L36_04640	COG1012	belongs to the aldehyde dehydrogenase family
I6L36_04650	COG3275	phosphorelay sensor kinase activity
I6L36_04655	COG3279	Response regulator of the LytR AlgR family
I6L36_04660	COG1966	Carbon starvation protein
I6L36_04665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L36_04665	COG3264	Mechanosensitive ion channel
I6L36_04670	COG0675	Transposase, IS605 OrfB family
I6L36_04685	COG1566	PFAM secretion protein HlyD family protein
I6L36_04690	COG1061	Type III restriction enzyme res subunit
I6L36_04695	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L36_04700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L36_04705	COG3385	transposase activity
I6L36_04715	COG0436	Aminotransferase
I6L36_04720	COG1288	antiporter activity
I6L36_04725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L36_04775	COG0697	spore germination
I6L36_04780	COG4657	Part of a membrane complex involved in electron transport
I6L36_04785	COG2878	Part of a membrane complex involved in electron transport
I6L36_04795	COG4658	electron transport chain
I6L36_04800	COG4659	FMN binding
I6L36_04805	COG4660	Part of a membrane complex involved in electron transport
I6L36_04810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L36_04815	COG0346	lactoylglutathione lyase activity
I6L36_04820	COG3385	transposase activity
I6L36_04840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L36_04850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L36_04855	COG1086	Polysaccharide biosynthesis protein
I6L36_04860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L36_04905	COG0438	transferase activity, transferring glycosyl groups
I6L36_04910	COG1216	Glycosyl transferase, family 2
I6L36_04925	COG1442	glycosyl transferase family 8
I6L36_04925	COG1216	Glycosyl transferase, family 2
I6L36_04940	COG0318	PFAM AMP-dependent synthetase and ligase
I6L36_04945	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_04960	COG1083	cytidylyl-transferase
I6L36_04970	COG2089	acid synthase
I6L36_05020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L36_05035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L36_05035	COG0301	tRNA thio-modification
I6L36_05045	COG4953	penicillin-binding protein 1C
I6L36_05050	COG2373	Large extracellular alpha-helical protein
I6L36_05055	COG0628	permease
I6L36_05060	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L36_05070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L36_05080	COG4160	amino acid transport
I6L36_05090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_05100	COG2431	L-lysine efflux transmembrane transporter activity
I6L36_05105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L36_05110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_05135	COG1393	Belongs to the ArsC family
I6L36_05145	COG4783	chaperone-mediated protein folding
I6L36_05150	COG0425	Belongs to the sulfur carrier protein TusA family
I6L36_05175	COG3842	ATPase activity
I6L36_05180	COG3833	ABC-type maltose transport systems, permease component
I6L36_05185	COG1175	transmembrane transport
I6L36_05195	COG3081	Nucleoid-associated protein
I6L36_05200	COG3082	Protein of unknown function (DUF1414)
I6L36_05205	COG3083	sulfuric ester hydrolase activity
I6L36_05215	COG4771	TonB-dependent receptor
I6L36_05220	COG1770	oligopeptidase
I6L36_05240	COG4574	serine-type endopeptidase inhibitor activity
I6L36_05245	COG3085	chromosome segregation
I6L36_05255	COG0287	Prephenate dehydrogenase
I6L36_05255	COG1605	Chorismate mutase
I6L36_05260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L36_05265	COG0584	glycerophosphoryl diester phosphodiesterase
I6L36_05275	COG1349	DNA-binding transcription factor activity
I6L36_05280	COG2271	Major facilitator Superfamily
I6L36_05285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L36_05290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L36_05295	COG0583	DNA-binding transcription factor activity
I6L36_05315	COG0656	L-ascorbic acid biosynthetic process
I6L36_05320	COG2814	Major facilitator Superfamily
I6L36_05330	COG1294	oxidase, subunit
I6L36_05335	COG1271	oxidase subunit
I6L36_05340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L36_05350	COG2979	Protein of unknown function (DUF533)
I6L36_05370	COG0583	DNA-binding transcription factor activity
I6L36_05380	COG2807	transmembrane transport
I6L36_05385	COG1187	pseudouridine synthase activity
I6L36_05390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L36_05405	COG1403	HNH endonuclease
I6L36_05430	COG1166	arginine decarboxylase activity
I6L36_05435	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L36_05450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L36_05465	COG0583	DNA-binding transcription factor activity
I6L36_05475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L36_05480	COG0840	transmembrane signaling receptor activity
I6L36_05485	COG0840	transmembrane signaling receptor activity
I6L36_05490	COG0302	gtp cyclohydrolase
I6L36_05500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L36_05505	COG2267	carboxylic ester hydrolase activity
I6L36_05510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L36_05525	COG0314	molybdopterin synthase activity
I6L36_05530	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L36_05535	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L36_05540	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L36_05545	COG3005	denitrification pathway
I6L36_05555	COG0348	domain, Protein
I6L36_05560	COG0437	4 iron, 4 sulfur cluster binding
I6L36_05565	COG0243	molybdopterin cofactor binding
I6L36_05575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L36_05575	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L36_05580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L36_05585	COG3850	Histidine kinase
I6L36_05590	COG2197	response regulator
I6L36_05615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6L36_05625	COG0121	glutamine amidotransferase
I6L36_05630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L36_05635	COG1960	acyl-CoA dehydrogenase activity
I6L36_05640	COG0784	Response regulator, receiver
I6L36_05640	COG3437	response regulator, receiver
I6L36_05650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L36_05655	COG0328	RNA-DNA hybrid ribonuclease activity
I6L36_05660	COG2226	methyltransferase
I6L36_05665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L36_05670	COG1388	LysM domain
I6L36_05670	COG0741	lytic transglycosylase activity
I6L36_05685	COG1607	acyl-coa hydrolase
I6L36_05700	COG0741	lytic transglycosylase activity
I6L36_05710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L36_05730	COG2911	Protein conserved in bacteria
I6L36_05735	COG0729	surface antigen
I6L36_05745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L36_05755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L36_05760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L36_05765	COG4134	Bacterial extracellular solute-binding protein
I6L36_05775	COG4136	ATPase activity
I6L36_05780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L36_05785	COG2951	lytic endotransglycosylase activity
I6L36_05790	COG1846	Transcriptional regulator
I6L36_05800	COG0033	Phosphoglucomutase
I6L36_05805	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L36_05810	COG0596	Alpha beta hydrolase
I6L36_05825	COG0716	FMN binding
I6L36_05835	COG0735	belongs to the Fur family
I6L36_05840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L36_05855	COG1263	PTS System
I6L36_05855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L36_05855	COG2190	(PTS) system
I6L36_05860	COG0363	glucosamine-6-phosphate deaminase activity
I6L36_05865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L36_05870	COG1940	carbohydrate kinase activity
I6L36_05870	COG1846	Transcriptional regulator
I6L36_05875	COG2194	sulfuric ester hydrolase activity
I6L36_05880	COG0217	transcriptional regulatory protein
I6L36_05885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L36_05890	COG1801	Protein of unknown function DUF72
I6L36_05895	COG4106	trans-aconitate 2-methyltransferase activity
I6L36_05900	COG0500	methyltransferase
I6L36_05920	COG0583	DNA-binding transcription factor activity
I6L36_05925	COG0791	NLP P60 protein
I6L36_05940	COG1309	transcriptional regulator
I6L36_05975	COG0534	Mate efflux family protein
I6L36_05985	COG2841	Protein conserved in bacteria
I6L36_05990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L36_05990	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L36_05990	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L36_05990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L36_06000	COG0633	Ferredoxin
I6L36_06000	COG3217	Mosc domain protein beta barrel domain protein
I6L36_06000	COG3217	Mosc domain protein beta barrel domain protein
I6L36_06000	COG0633	Ferredoxin
I6L36_06005	COG0501	Belongs to the peptidase M48B family
I6L36_06010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L36_06015	COG1073	alpha beta
I6L36_06015	COG2226	methyltransferase
I6L36_06020	COG0156	8-amino-7-oxononanoate synthase activity
I6L36_06025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L36_06050	COG0017	Asparaginyl-tRNA synthetase
I6L36_06055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L36_06070	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L36_06080	COG1393	Belongs to the ArsC family
I6L36_06085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L36_06090	COG1876	peptidase activity
I6L36_06100	COG3263	regulation of cellular component size
I6L36_06110	COG1280	lysine exporter protein (LysE YggA)
I6L36_06135	COG1957	nucleoside hydrolase
I6L36_06140	COG0564	pseudouridine synthase activity
I6L36_06150	COG1454	alcohol dehydrogenase
I6L36_06155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L36_06160	COG0702	epimerase
I6L36_06165	COG2914	Belongs to the UPF0125 (RnfH) family
I6L36_06170	COG2867	negative regulation of translational initiation
I6L36_06175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L36_06450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L36_06530	COG0582	viral genome integration into host DNA
I6L36_06535	COG0582	viral genome integration into host DNA
I6L36_06605	COG0653	protein targeting
I6L36_06615	COG0800	Aldolase
I6L36_06630	COG3153	acetyltransferase
I6L36_06660	COG0259	pyridoxamine-phosphate oxidase activity
I6L36_06675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L36_06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L36_06680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L36_06695	COG0457	Tetratricopeptide repeat
I6L36_06705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L36_06710	COG1138	Cytochrome C-type biogenesis protein
I6L36_06715	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L36_06720	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L36_06725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L36_06730	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L36_06745	COG0835	chemotaxis
I6L36_06755	COG1192	Involved in chromosome partitioning
I6L36_06760	COG1360	Flagellar Motor Protein
I6L36_06765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L36_06770	COG2201	protein-glutamate methylesterase activity
I6L36_06775	COG2198	Histidine kinase
I6L36_06775	COG0784	Response regulator, receiver
I6L36_06775	COG0643	Histidine kinase
I6L36_06780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L36_06805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L36_06815	COG1684	flagellar biosynthetic protein fliR
I6L36_06870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L36_06880	COG1677	Flagellar hook-basal body complex protein FliE
I6L36_06895	COG1393	Belongs to the ArsC family
I6L36_06900	COG0798	PFAM Bile acid sodium symporter
I6L36_06905	COG0640	Transcriptional regulator
I6L36_06945	COG1538	Outer membrane efflux protein
I6L36_06950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_06965	COG0745	RESPONSE REGULATOR receiver
I6L36_06970	COG5002	protein histidine kinase activity
I6L36_06980	COG2217	Heavy metal translocating P-type atpase
I6L36_07005	COG2132	Multicopper oxidase
I6L36_07025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L36_07040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L36_07045	COG0444	Belongs to the ABC transporter superfamily
I6L36_07050	COG4608	Belongs to the ABC transporter superfamily
I6L36_07060	COG2971	BadF BadG BcrA BcrD
I6L36_07070	COG0840	transmembrane signaling receptor activity
I6L36_07090	COG3724	N-succinylarginine dihydrolase activity
I6L36_07095	COG0616	signal peptide processing
I6L36_07100	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_07105	COG0583	DNA-binding transcription factor activity
I6L36_07115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L36_07125	COG0583	DNA-binding transcription factor activity
I6L36_07130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L36_07135	COG1881	PFAM PEBP family protein
I6L36_07145	COG3408	Glycogen debranching enzyme
I6L36_07145	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L36_07150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L36_07155	COG0739	heme binding
I6L36_07160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L36_07175	COG0251	oxidation-reduction process
I6L36_07185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L36_07195	COG3091	SprT-like family
I6L36_07205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L36_07210	COG0189	ligase activity
I6L36_07220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L36_07240	COG1115	amino acid carrier protein
I6L36_07245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L36_07260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L36_07270	COG1301	dicarboxylic acid transport
I6L36_07275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L36_07280	COG2912	Transglutaminase-like superfamily
I6L36_07290	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L36_07295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L36_07300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L36_07305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L36_07310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L36_07320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L36_07325	COG0193	aminoacyl-tRNA hydrolase activity
I6L36_07330	COG0012	GTP binding
I6L36_07375	COG0471	metal ion transport
I6L36_07375	COG0490	domain, Protein
I6L36_07385	COG0657	acetylesterase activity
I6L36_07400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L36_07415	COG1012	belongs to the aldehyde dehydrogenase family
I6L36_07425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L36_07440	COG0180	Tryptophanyl-tRNA synthetase
I6L36_07445	COG0546	phosphoglycolate phosphatase activity
I6L36_07450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L36_07455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L36_07465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L36_07470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L36_07500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L36_07505	COG3385	transposase activity
I6L36_07510	COG0583	DNA-binding transcription factor activity
I6L36_07525	COG0583	DNA-binding transcription factor activity
I6L36_07540	COG0739	heme binding
I6L36_07550	COG1511	domain protein
I6L36_07550	COG3264	Mechanosensitive ion channel
I6L36_07555	COG0584	glycerophosphoryl diester phosphodiesterase
I6L36_07565	COG1053	succinate dehydrogenase
I6L36_07570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L36_07575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L36_07580	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L36_07590	COG3214	Protein conserved in bacteria
I6L36_07595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L36_07605	COG1022	Amp-dependent synthetase and ligase
I6L36_07615	COG0300	oxidoreductase activity
I6L36_07635	COG4067	protein conserved in archaea
I6L36_07635	COG0189	ligase activity
I6L36_07640	COG0516	GMP reductase activity
I6L36_07650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L36_07655	COG2011	ABC-type metal ion transport system permease component
I6L36_07660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L36_07665	COG1464	Belongs to the NlpA lipoprotein family
I6L36_07680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L36_07690	COG2199	diguanylate cyclase activity
I6L36_07705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L36_07720	COG1335	isochorismatase
I6L36_07725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L36_07730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L36_07735	COG1702	phosphate starvation-inducible protein PhoH
I6L36_07740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L36_07745	COG4535	Mg2 and Co2 transporter CorC
I6L36_07750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L36_07755	COG2888	peptidyl-tyrosine sulfation
I6L36_07760	COG0495	leucyl-tRNA aminoacylation
I6L36_07775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L36_07780	COG0799	negative regulation of ribosome biogenesis
I6L36_07785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L36_07790	COG0768	penicillin binding
I6L36_07795	COG0772	Belongs to the SEDS family
I6L36_07800	COG2951	lytic endotransglycosylase activity
I6L36_07805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L36_07810	COG1686	Belongs to the peptidase S11 family
I6L36_07815	COG2921	Belongs to the UPF0250 family
I6L36_07820	COG0321	lipoyl(octanoyl) transferase activity
I6L36_07825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L36_07850	COG0789	Transcriptional regulator
I6L36_07855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L36_07865	COG1970	mechanosensitive ion channel activity
I6L36_07870	COG4974	Belongs to the 'phage' integrase family
I6L36_07880	COG0312	modulator of DNA gyrase
I6L36_07885	COG0312	modulator of DNA gyrase
I6L36_07900	COG0826	peptidase U32
I6L36_07905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L36_07910	COG1422	Protein of unknown function (DUF1090)
I6L36_07915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L36_07920	COG2211	Major facilitator Superfamily
I6L36_07925	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L36_07935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L36_07940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L36_07945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L36_07950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L36_07955	COG0195	Participates in both transcription termination and antitermination
I6L36_07960	COG0779	Required for maturation of 30S ribosomal subunits
I6L36_07975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L36_07980	COG0149	triose-phosphate isomerase activity
I6L36_07985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L36_07990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L36_08000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L36_08005	COG1534	Rna-binding protein
I6L36_08020	COG1360	Flagellar Motor Protein
I6L36_08025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L36_08030	COG1722	exodeoxyribonuclease VII activity
I6L36_08035	COG0142	geranyltranstransferase activity
I6L36_08040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L36_08045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L36_08050	COG0601	transmembrane transport
I6L36_08060	COG4172	Belongs to the ABC transporter superfamily
I6L36_08065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L36_08070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L36_08075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L36_08080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L36_08095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L36_08095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L36_08100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L36_08110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L36_08120	COG3381	protein complex oligomerization
I6L36_08135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L36_08140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L36_08145	COG0511	ligase activity, forming carbon-carbon bonds
I6L36_08150	COG0439	Biotin carboxylase
I6L36_08155	COG3924	membrane
I6L36_08160	COG4145	pantothenate transmembrane transporter activity
I6L36_08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L36_08165	COG1263	PTS System
I6L36_08165	COG2190	(PTS) system
I6L36_08170	COG0583	DNA-binding transcription factor activity
I6L36_08175	COG0604	alcohol dehydrogenase
I6L36_08185	COG2264	protein methyltransferase activity
I6L36_08190	COG0110	maltose O-acetyltransferase activity
I6L36_08200	COG0778	Nitroreductase
I6L36_08205	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L36_08205	COG1902	pentaerythritol trinitrate reductase activity
I6L36_08210	COG0616	signal peptide processing
I6L36_08235	COG3139	Protein of unknown function (DUF1315)
I6L36_08240	COG0252	asparaginase activity
I6L36_08245	COG0786	glutamate:sodium symporter activity
I6L36_08260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L36_08265	COG0384	phenazine biosynthesis protein PhzF
I6L36_08270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L36_08275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L36_08280	COG0175	sulfate reduction
I6L36_08285	COG2113	Glycine betaine
I6L36_08290	COG4176	ABC-type proline glycine betaine transport system permease component
I6L36_08295	COG4175	Glycine betaine
I6L36_08305	COG3610	response to peptide
I6L36_08310	COG2966	Psort location CytoplasmicMembrane, score
I6L36_08320	COG5433	transposase activity
I6L36_08330	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L36_08350	COG2313	pseudouridylate synthase activity
I6L36_08355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L36_08360	COG2146	nitrite reductase [NAD(P)H] activity
I6L36_08360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L36_08365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L36_08365	COG2146	nitrite reductase [NAD(P)H] activity
I6L36_08370	COG1116	anion transmembrane transporter activity
I6L36_08375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L36_08380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L36_08380	COG1116	anion transmembrane transporter activity
I6L36_08390	COG1648	precorrin-2 dehydrogenase activity
I6L36_08390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L36_08395	COG0243	molybdopterin cofactor binding
I6L36_08420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L36_08435	COG1073	alpha beta
I6L36_08440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L36_08445	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L36_08450	COG4608	Belongs to the ABC transporter superfamily
I6L36_08455	COG0444	Belongs to the ABC transporter superfamily
I6L36_08465	COG4239	(ABC) transporter, permease
I6L36_08470	COG4174	ABC transporter (Permease)
I6L36_08475	COG4206	TonB-dependent receptor
I6L36_08485	COG0811	peptide transport
I6L36_08490	COG0811	peptide transport
I6L36_08495	COG0848	biopolymer transport protein
I6L36_08545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L36_08550	COG0840	transmembrane signaling receptor activity
I6L36_08560	COG1278	Cold shock
I6L36_08600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L36_08605	COG1162	GTPase activity
I6L36_08610	COG0688	phosphatidylethanolamine metabolic process
I6L36_08615	COG4628	conserved protein (DUF2132)
I6L36_08635	COG3300	MHYT domain
I6L36_08635	COG5001	Diguanylate cyclase
I6L36_08640	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L36_08665	COG1132	(ABC) transporter
I6L36_08675	COG2897	thiosulfate sulfurtransferase activity
I6L36_08680	COG2066	Belongs to the glutaminase family
I6L36_08685	COG3171	Protein conserved in bacteria
I6L36_08690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L36_08695	COG2234	aminopeptidase activity
I6L36_08695	COG4935	Belongs to the peptidase S8 family
I6L36_08700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L36_08705	COG2200	EAL domain
I6L36_08710	COG1090	epimerase
I6L36_08715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L36_08720	COG4181	ATPase activity
I6L36_08725	COG2755	lipolytic protein G-D-S-L family
I6L36_08730	COG0784	Response regulator, receiver
I6L36_08730	COG0835	chemotaxis
I6L36_08740	COG0675	Transposase, IS605 OrfB family
I6L36_08750	COG0516	GMP reductase activity
I6L36_08750	COG0517	IMP dehydrogenase activity
I6L36_08755	COG0488	(ABC) transporter
I6L36_08765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L36_08800	COG0789	Transcriptional regulator
I6L36_08810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L36_08820	COG0668	transmembrane transport
I6L36_08830	COG2731	YhcH YjgK YiaL family protein
I6L36_08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L36_08845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L36_08850	COG3227	Zinc metalloprotease (Elastase)
I6L36_08855	COG0583	DNA-binding transcription factor activity
I6L36_08860	COG0477	Major facilitator Superfamily
I6L36_08880	COG2985	domain, Protein
I6L36_08880	COG0569	domain protein
I6L36_08885	COG1272	protein, Hemolysin III
I6L36_08890	COG0076	glutamate decarboxylase activity
I6L36_08895	COG2917	probably involved in intracellular septation
I6L36_08900	COG2350	Protein conserved in bacteria
I6L36_08910	COG1555	photosystem II stabilization
I6L36_08915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L36_08920	COG3104	oligopeptide transport
I6L36_08925	COG0745	RESPONSE REGULATOR receiver
I6L36_08955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_08970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L36_08975	COG1280	lysine exporter protein (LysE YggA)
I6L36_09000	COG0316	Belongs to the HesB IscA family
I6L36_09010	COG0038	chloride channel
I6L36_09015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L36_09030	COG0671	phosphoesterase, PA-phosphatase related
I6L36_09040	COG0583	DNA-binding transcription factor activity
I6L36_09045	COG2076	Multidrug Resistance protein
I6L36_09055	COG0346	lactoylglutathione lyase activity
I6L36_09060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L36_09065	COG1643	Atp-dependent helicase
I6L36_09075	COG1489	DNA binding
I6L36_09080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L36_09085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L36_09095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L36_09100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L36_09105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L36_09115	COG0842	Transport permease protein
I6L36_09120	COG1131	(ABC) transporter
I6L36_09135	COG0163	prenyltransferase activity
I6L36_09140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L36_09145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L36_09160	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L36_09175	COG1136	(ABC) transporter
I6L36_09210	COG0529	Catalyzes the synthesis of activated sulfate
I6L36_09215	COG3273	potassium ion transport
I6L36_09215	COG0471	metal ion transport
I6L36_09220	COG2895	sulfate adenylyltransferase (ATP) activity
I6L36_09225	COG0175	sulfate reduction
I6L36_09230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L36_09230	COG1648	precorrin-2 dehydrogenase activity
I6L36_09235	COG0330	HflC and HflK could
I6L36_09240	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L36_09250	COG0673	inositol 2-dehydrogenase activity
I6L36_09255	COG2814	Major facilitator Superfamily
I6L36_09260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L36_09265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L36_09270	COG3036	rescue of stalled ribosome
I6L36_09285	COG0138	bifunctional purine biosynthesis protein purh
I6L36_09320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L36_09325	COG0358	DNA primase activity
I6L36_09330	COG1610	YqeY-like protein
I6L36_09335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L36_09340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L36_09350	COG4942	peptidase
I6L36_09350	COG1388	LysM domain
I6L36_09355	COG1238	metal cluster binding
I6L36_09360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L36_09365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L36_09370	COG0585	pseudouridine synthase activity
I6L36_09380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L36_09385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L36_09390	COG0148	phosphopyruvate hydratase activity
I6L36_09395	COG0504	CTP synthase activity
I6L36_09400	COG3956	TIGRFAM MazG family protein
I6L36_09405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L36_09410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L36_09420	COG4807	Protein conserved in bacteria
I6L36_09425	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L36_09430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L36_09435	COG1381	Involved in DNA repair and RecF pathway recombination
I6L36_09445	COG0571	ribonuclease III activity
I6L36_09450	COG0681	Belongs to the peptidase S26 family
I6L36_09455	COG0481	GTPase activity
I6L36_09470	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L36_09475	COG1595	DNA-templated transcription, initiation
I6L36_09480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L36_09490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L36_09495	COG0354	folic acid binding
I6L36_09500	COG0583	DNA-binding transcription factor activity
I6L36_09530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L36_09540	COG0126	phosphoglycerate kinase activity
I6L36_09545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L36_09550	COG1940	carbohydrate kinase activity
I6L36_09555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L36_09560	COG2816	NAD+ diphosphatase activity
I6L36_09565	COG4991	sh3 domain protein
I6L36_09570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L36_09585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L36_09590	COG1028	Short-chain dehydrogenase reductase Sdr
I6L36_09600	COG1505	serine-type exopeptidase activity
I6L36_09605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L36_09610	COG0765	amino acid transport
I6L36_09615	COG0765	amino acid transport
I6L36_09620	COG1126	abc transporter atp-binding protein
I6L36_09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_09630	COG3174	membrane
I6L36_09635	COG0110	maltose O-acetyltransferase activity
I6L36_09675	COG0165	Argininosuccinate lyase
I6L36_09680	COG0137	argininosuccinate synthase activity
I6L36_09690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L36_09695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L36_09705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L36_09715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L36_09750	COG0583	DNA-binding transcription factor activity
I6L36_09755	COG1380	Effector of murein hydrolase LrgA
I6L36_09760	COG1346	cytolysis
I6L36_09765	COG0527	aspartate kinase activity
I6L36_09765	COG0460	homoserine dehydrogenase
I6L36_09770	COG0626	cystathionine gamma-synthase activity
I6L36_09785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L36_09790	COG0814	amino acid
I6L36_09795	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L36_09800	COG0494	nUDIX hydrolase
I6L36_09805	COG1011	Hydrolase
I6L36_09810	COG1902	pentaerythritol trinitrate reductase activity
I6L36_09820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L36_09835	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L36_09845	COG3156	type II secretion system protein K
I6L36_09850	COG4795	General secretion pathway protein
I6L36_09855	COG2165	general secretion pathway protein
I6L36_09865	COG2165	general secretion pathway protein
I6L36_09870	COG1459	type II secretion system
I6L36_09875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L36_09885	COG3031	protein transport across the cell outer membrane
I6L36_09895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L36_09900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L36_09915	COG0456	acetyltransferase
I6L36_09920	COG3133	Outer membrane lipoprotein
I6L36_09925	COG3025	triphosphatase activity
I6L36_09930	COG1392	Phosphate transport regulator
I6L36_09935	COG0306	phosphate transporter
I6L36_09940	COG0617	tRNA 3'-terminal CCA addition
I6L36_09945	COG3267	Type II secretory pathway component ExeA
I6L36_09945	COG3409	Peptidoglycan-binding domain 1 protein
I6L36_09955	COG1194	a g-specific adenine glycosylase
I6L36_09960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L36_09975	COG3240	lipase activity
I6L36_09985	COG3009	Protein conserved in bacteria
I6L36_09990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L36_09990	COG3008	intermembrane lipid transfer
I6L36_09995	COG2995	paraquat-inducible protein a
I6L36_10005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L36_10010	COG4251	negative regulation of phosphorylation
I6L36_10010	COG5001	Diguanylate cyclase
I6L36_10010	COG2203	Gaf domain
I6L36_10010	COG3706	GGDEF domain
I6L36_10015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L36_10020	COG2813	Specifically methylates the guanine in position
I6L36_10025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L36_10030	COG0297	glycogen (starch) synthase activity
I6L36_10070	COG1757	Na H antiporter
I6L36_10075	COG0583	DNA-binding transcription factor activity
I6L36_10085	COG3842	ATPase activity
I6L36_10090	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L36_10095	COG1177	transmembrane transport
I6L36_10105	COG0109	protoheme IX farnesyltransferase activity
I6L36_10135	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6L36_10145	COG1565	acr, cog1565
I6L36_10145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L36_10150	COG1444	tRNA N-acetyltransferase activity
I6L36_10170	COG1803	Methylglyoxal synthase
I6L36_10185	COG0252	asparaginase activity
I6L36_10205	COG1263	PTS System
I6L36_10205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L36_10210	COG0366	Alpha amylase catalytic
I6L36_10215	COG0110	maltose O-acetyltransferase activity
I6L36_10220	COG1522	sequence-specific DNA binding
I6L36_10250	COG3068	Protein conserved in bacteria
I6L36_10260	COG0739	heme binding
I6L36_10280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L36_10285	COG1121	(ABC) transporter
I6L36_10290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L36_10295	COG0583	DNA-binding transcription factor activity
I6L36_10305	COG1573	uracil-dna glycosylase
I6L36_10310	COG2962	Rard protein
I6L36_10315	COG2827	Endonuclease containing a URI domain
I6L36_10330	COG1842	Phage shock protein A
I6L36_10335	COG0204	Acyl-transferase
I6L36_10355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L36_10420	COG1289	transmembrane transporter activity
I6L36_10425	COG1566	PFAM secretion protein HlyD family protein
I6L36_10440	COG1051	belongs to the nudix hydrolase family
I6L36_10445	COG3150	esterase
I6L36_10455	COG3151	Protein conserved in bacteria
I6L36_10460	COG0494	nUDIX hydrolase
I6L36_10465	COG1538	Outer membrane efflux protein
I6L36_10470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L36_10470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L36_10475	COG1560	Kdo2-lipid A biosynthetic process
I6L36_10490	COG2771	luxR family
I6L36_10495	COG3916	Acyl-homoserine-lactone synthase
I6L36_10505	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L36_10515	COG2213	PTS system mannitol-specific
I6L36_10515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_10520	COG0246	Mannitol dehydrogenase
I6L36_10525	COG3722	fumarate hydratase activity
I6L36_10530	COG3263	regulation of cellular component size
I6L36_10550	COG1671	Belongs to the UPF0178 family
I6L36_10570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L36_10575	COG0513	Belongs to the DEAD box helicase family
I6L36_10595	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L36_10600	COG1169	isochorismate synthase
I6L36_10605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L36_10610	COG0596	Alpha beta hydrolase
I6L36_10615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L36_10620	COG1441	menaquinone biosynthetic process
I6L36_10625	COG0318	PFAM AMP-dependent synthetase and ligase
I6L36_10630	COG3291	Pkd domain containing protein
I6L36_10635	COG2949	membrane
I6L36_10640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L36_10650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L36_10680	COG2873	o-acetylhomoserine
I6L36_10690	COG1979	alcohol dehydrogenase
I6L36_10705	COG4221	oxidoreductase activity
I6L36_10740	COG1368	sulfuric ester hydrolase activity
I6L36_10745	COG1522	sequence-specific DNA binding
I6L36_10755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L36_10760	COG1418	mRNA catabolic process
I6L36_10765	COG1058	Belongs to the CinA family
I6L36_10765	COG1546	Belongs to the CinA family
I6L36_10770	COG1988	membrane-bound metal-dependent
I6L36_10785	COG0561	phosphatase activity
I6L36_10790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L36_10800	COG1011	Hydrolase
I6L36_10815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L36_10820	COG0019	diaminopimelate decarboxylase activity
I6L36_10830	COG1965	Belongs to the frataxin family
I6L36_10835	COG0400	carboxylic ester hydrolase activity
I6L36_10840	COG3072	Adenylate cyclase
I6L36_10845	COG0181	hydroxymethylbilane synthase activity
I6L36_10855	COG2959	enzyme of heme biosynthesis
I6L36_10860	COG3071	HemY protein
I6L36_10865	COG0312	modulator of DNA gyrase
I6L36_10870	COG3028	Belongs to the UPF0307 family
I6L36_10880	COG2926	Belongs to the UPF0265 family
I6L36_10915	COG1396	sequence-specific DNA binding
I6L36_10920	COG3135	benzoate transporter
I6L36_10950	COG3047	cAMP biosynthetic process
I6L36_10955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L36_10960	COG2197	response regulator
I6L36_10980	COG1278	Cold shock
I6L36_11010	COG3706	GGDEF domain
I6L36_11015	COG0347	Belongs to the P(II) protein family
I6L36_11020	COG0004	ammonium transporteR
I6L36_11025	COG3039	Transposase
I6L36_11030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L36_11035	COG1074	ATP-dependent DNA helicase activity
I6L36_11040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L36_11045	COG2259	Doxx family
I6L36_11050	COG1741	Belongs to the pirin family
I6L36_11060	COG0583	DNA-binding transcription factor activity
I6L36_11085	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L36_11095	COG3842	ATPase activity
I6L36_11125	COG0456	acetyltransferase
I6L36_11130	COG0753	catalase activity
I6L36_11150	COG0494	nUDIX hydrolase
I6L36_11155	COG0628	permease
I6L36_11180	COG2957	Belongs to the agmatine deiminase family
I6L36_11185	COG0583	DNA-binding transcription factor activity
I6L36_11205	COG2376	Dihydroxyacetone kinase
I6L36_11210	COG2252	PERMEase
I6L36_11215	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6L36_11250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L36_11255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L36_11260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L36_11265	COG0049	tRNA binding
I6L36_11270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L36_11275	COG2168	tRNA wobble position uridine thiolation
I6L36_11285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L36_11290	COG0251	oxidation-reduction process
I6L36_11295	COG2964	Protein conserved in bacteria
I6L36_11300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L36_11305	COG0085	RNA polymerase activity
I6L36_11310	COG0222	ribosome binding
I6L36_11315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L36_11320	COG0081	regulation of translation
I6L36_11325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L36_11330	COG0250	Participates in transcription elongation, termination and antitermination
I6L36_11345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L36_11370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L36_11375	COG0569	domain protein
I6L36_11380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L36_11385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L36_11390	COG3005	denitrification pathway
I6L36_11395	COG0243	molybdopterin cofactor binding
I6L36_11430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6L36_11440	COG2204	response regulator
I6L36_11450	COG2205	protein histidine kinase activity
I6L36_11470	COG0517	IMP dehydrogenase activity
I6L36_11470	COG0516	GMP reductase activity
I6L36_11480	COG1522	sequence-specific DNA binding
I6L36_11485	COG2502	aspartate--ammonia ligase
I6L36_11490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L36_11495	COG0542	response to heat
I6L36_11505	COG0564	pseudouridine synthase activity
I6L36_11510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L36_11515	COG3681	Belongs to the UPF0597 family
I6L36_11520	COG2964	Protein conserved in bacteria
I6L36_11535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L36_11540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L36_11545	COG1979	alcohol dehydrogenase
I6L36_11550	COG2207	Transcriptional regulator
I6L36_11555	COG3040	lipid binding
I6L36_11575	COG5433	transposase activity
I6L36_11620	COG0540	Belongs to the ATCase OTCase family
I6L36_11625	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L36_11630	COG1438	arginine binding
I6L36_11635	COG1288	antiporter activity
I6L36_11640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L36_11680	COG3250	beta-galactosidase activity
I6L36_11685	COG1609	Transcriptional regulator
I6L36_11690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L36_11700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L36_11705	COG2017	converts alpha-aldose to the beta-anomer
I6L36_11715	COG1968	undecaprenyl-diphosphatase activity
I6L36_11725	COG3806	Anti-sigma factor
I6L36_11730	COG1595	DNA-templated transcription, initiation
I6L36_11750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L36_11755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L36_11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_11780	COG1131	(ABC) transporter
I6L36_11785	COG0842	Transport permease protein
I6L36_11790	COG0842	Transport permease protein
I6L36_11795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L36_11805	COG2116	formate transmembrane transporter activity
I6L36_11810	COG1648	precorrin-2 dehydrogenase activity
I6L36_11810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L36_11815	COG2239	Acts as a magnesium transporter
I6L36_11820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L36_11825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L36_11835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L36_11845	COG0514	ATP-dependent DNA helicase (RecQ)
I6L36_11850	COG2050	protein possibly involved in aromatic compounds catabolism
I6L36_11865	COG2258	MOSC domain
I6L36_11870	COG1177	transmembrane transport
I6L36_11875	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L36_11880	COG3842	ATPase activity
I6L36_11900	COG0174	glutamine synthetase
I6L36_11920	COG3045	CreA protein
I6L36_11925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L36_11930	COG0443	Heat shock 70 kDa protein
I6L36_11945	COG0366	Alpha amylase catalytic
I6L36_11960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L36_11965	COG0745	RESPONSE REGULATOR receiver
I6L36_11975	COG2205	protein histidine kinase activity
I6L36_11985	COG0281	malic enzyme
I6L36_11990	COG0702	epimerase
I6L36_11995	COG0254	rRNA binding
I6L36_12000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L36_12005	COG1309	transcriptional regulator
I6L36_12025	COG0129	dihydroxy-acid dehydratase activity
I6L36_12035	COG3978	acetolactate synthase activity
I6L36_12045	COG0606	chelatase, subunit chli
I6L36_12050	COG0204	Acyl-transferase
I6L36_12055	COG0204	Acyl-transferase
I6L36_12060	COG1683	Conserved Protein
I6L36_12075	COG1335	isochorismatase
I6L36_12085	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L36_12090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6L36_12095	COG3639	organic phosphonate transmembrane transporter activity
I6L36_12100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L36_12105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L36_12115	COG3084	Protein conserved in bacteria
I6L36_12120	COG5001	Diguanylate cyclase
I6L36_12120	COG4251	negative regulation of phosphorylation
I6L36_12120	COG3706	GGDEF domain
I6L36_12120	COG2203	Gaf domain
I6L36_12135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L36_12140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L36_12145	COG1561	YicC-like family, N-terminal region
I6L36_12155	COG1519	Transferase
I6L36_12160	COG0859	PFAM glycosyl transferase family 9
I6L36_12165	COG0463	Glycosyl transferase, family 2
I6L36_12170	COG0859	PFAM glycosyl transferase family 9
I6L36_12175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L36_12185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L36_12195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L36_12200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L36_12205	COG2003	Belongs to the UPF0758 family
I6L36_12210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L36_12215	COG0756	dUTP diphosphatase activity
I6L36_12220	COG1309	transcriptional regulator
I6L36_12235	COG0668	transmembrane transport
I6L36_12245	COG0166	Belongs to the GPI family
I6L36_12250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L36_12255	COG0583	DNA-binding transcription factor activity
I6L36_12265	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L36_12265	COG1042	CoA-binding domain protein
I6L36_12265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L36_12310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L36_12315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L36_12325	COG3039	Transposase
I6L36_12375	COG1280	lysine exporter protein (LysE YggA)
I6L36_12380	COG2223	nitrite transmembrane transporter activity
I6L36_12385	COG2081	HI0933 family
I6L36_12390	COG1528	Iron-storage protein
I6L36_12395	COG3706	GGDEF domain
I6L36_12400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L36_12405	COG0589	response to stress
I6L36_12445	COG3642	lipopolysaccharide core region biosynthetic process
I6L36_12450	COG0859	PFAM glycosyl transferase family 9
I6L36_12460	COG1758	RNA polymerase activity
I6L36_12465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L36_12470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L36_12475	COG2267	carboxylic ester hydrolase activity
I6L36_12480	COG0561	phosphatase activity
I6L36_12510	COG1309	transcriptional regulator
I6L36_12515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_12520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_12525	COG4191	Histidine kinase
I6L36_12530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L36_12550	COG2205	protein histidine kinase activity
I6L36_12555	COG0745	RESPONSE REGULATOR receiver
I6L36_12560	COG2814	Major facilitator Superfamily
I6L36_12575	COG3977	Valine--pyruvate aminotransferase
I6L36_12580	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L36_12585	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L36_12590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L36_12595	COG2207	Transcriptional regulator
I6L36_12610	COG0592	DNA-directed DNA polymerase activity
I6L36_12615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L36_12630	COG1126	abc transporter atp-binding protein
I6L36_12635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L36_12640	COG0594	ribonuclease P activity
I6L36_12645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L36_12650	COG0706	membrane insertase activity
I6L36_12655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L36_12665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L36_12670	COG1120	ATPase activity
I6L36_12675	COG4615	Cyclic peptide transporter
I6L36_12680	COG4774	siderophore transport
I6L36_12685	COG0716	FMN binding
I6L36_12690	COG0445	tRNA wobble uridine modification
I6L36_12695	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L36_12700	COG1192	Involved in chromosome partitioning
I6L36_12705	COG1475	DNA binding
I6L36_12715	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L36_12725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L36_12730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L36_12735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L36_12740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L36_12745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L36_12750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L36_12755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L36_12760	COG4452	Inner membrane protein CreD
I6L36_12770	COG2205	protein histidine kinase activity
I6L36_12775	COG0745	RESPONSE REGULATOR receiver
I6L36_12780	COG1349	DNA-binding transcription factor activity
I6L36_12785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L36_12790	COG2771	luxR family
I6L36_12800	COG0811	peptide transport
I6L36_12805	COG0811	peptide transport
I6L36_12810	COG0848	biopolymer transport protein
I6L36_12815	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L36_12855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L36_12860	COG2166	iron-sulfur cluster assembly
I6L36_12865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L36_12885	COG1063	alcohol dehydrogenase
I6L36_12890	COG0156	8-amino-7-oxononanoate synthase activity
I6L36_12900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L36_12945	COG1609	Transcriptional regulator
I6L36_12960	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L36_12965	COG3161	chorismate lyase activity
I6L36_12970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L36_12975	COG2937	Belongs to the GPAT DAPAT family
I6L36_12980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L36_12995	COG0534	Mate efflux family protein
I6L36_13000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L36_13005	COG2205	protein histidine kinase activity
I6L36_13010	COG0745	RESPONSE REGULATOR receiver
I6L36_13020	COG1045	serine acetyltransferase
I6L36_13030	COG3074	FtsZ-dependent cytokinesis
I6L36_13035	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L36_13040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L36_13040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L36_13045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L36_13075	COG0402	S-adenosylhomocysteine deaminase activity
I6L36_13080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L36_13090	COG3165	ubiquinone biosynthetic process from chorismate
I6L36_13095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L36_13100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L36_13105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L36_13110	COG0805	protein transport
I6L36_13115	COG0084	hydrolase, TatD family'
I6L36_13135	COG0742	ribosomal rna small subunit methyltransferase
I6L36_13150	COG0248	Ppx GppA phosphatase
I6L36_13155	COG0513	Belongs to the DEAD box helicase family
I6L36_13160	COG3118	belongs to the thioredoxin family
I6L36_13175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L36_13185	COG2960	long-chain fatty acid transporting porin activity
I6L36_13200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L36_13240	COG1609	Transcriptional regulator
I6L36_13245	COG3604	Transcriptional regulator
I6L36_13250	COG1773	rubredoxin
I6L36_13250	COG0426	domain, Protein
I6L36_13255	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L36_13265	COG0348	domain, Protein
I6L36_13295	COG0814	amino acid
I6L36_13300	COG0814	amino acid
I6L36_13325	COG4251	negative regulation of phosphorylation
I6L36_13325	COG5001	Diguanylate cyclase
I6L36_13325	COG2203	Gaf domain
I6L36_13325	COG3706	GGDEF domain
I6L36_13340	COG0751	glycine-tRNA ligase activity
I6L36_13345	COG0752	glycyl-tRNA synthetase alpha subunit
I6L36_13350	COG2818	Glycosylase
I6L36_13355	COG1335	isochorismatase
I6L36_13365	COG2885	chlorophyll binding
I6L36_13385	COG0251	oxidation-reduction process
I6L36_13390	COG0425	Belongs to the sulfur carrier protein TusA family
I6L36_13415	COG0183	Belongs to the thiolase family
I6L36_13420	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L36_13420	COG1024	Enoyl-CoA hydratase
I6L36_13425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L36_13430	COG0006	proline dipeptidase activity
I6L36_13435	COG1739	Uncharacterized protein family UPF0029
I6L36_13440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L36_13445	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L36_13480	COG1609	Transcriptional regulator
I6L36_13485	COG3250	beta-galactosidase activity
I6L36_13490	COG2731	YhcH YjgK YiaL family protein
I6L36_13495	COG0531	amino acid
I6L36_13500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L36_13505	COG0531	amino acid
I6L36_13510	COG0385	Bile acid
I6L36_13515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L36_13540	COG0583	DNA-binding transcription factor activity
I6L36_13545	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L36_13550	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L36_13555	COG3845	ABC transporter
I6L36_13560	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L36_13575	COG0210	DNA helicase
I6L36_13610	COG0583	DNA-binding transcription factor activity
I6L36_13650	COG1280	lysine exporter protein (LysE YggA)
I6L36_13660	COG2962	Rard protein
I6L36_13670	COG1012	belongs to the aldehyde dehydrogenase family
I6L36_13675	COG1396	sequence-specific DNA binding
I6L36_13680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L36_13690	COG0519	Catalyzes the synthesis of GMP from XMP
I6L36_13690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L36_13700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L36_13720	COG1322	Protein conserved in bacteria
I6L36_13725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L36_13730	COG0569	domain protein
I6L36_13735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L36_13735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L36_13740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L36_13745	COG0242	peptide deformylase activity
I6L36_13755	COG0758	DNA mediated transformation
I6L36_13760	COG2922	Belongs to the Smg family
I6L36_13765	COG0551	DNA topoisomerase type I activity
I6L36_13770	COG0009	L-threonylcarbamoyladenylate synthase
I6L36_13775	COG0408	coproporphyrinogen oxidase activity
I6L36_13780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L36_13785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L36_13795	COG3078	GTPase activator activity
I6L36_13805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L36_13810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L36_13820	COG3852	Histidine kinase
I6L36_13830	COG0174	glutamine synthetase
I6L36_13835	COG1217	gtp-binding protein TYPA
I6L36_13840	COG1295	ribonuclease BN
I6L36_13845	COG1490	D-aminoacyl-tRNA deacylase activity
I6L36_13855	COG0456	acetyltransferase
I6L36_13865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L36_13870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L36_13875	COG2610	gluconate transmembrane transporter activity
I6L36_13880	COG3265	gluconokinase activity
I6L36_13885	COG0129	dihydroxy-acid dehydratase activity
I6L36_13890	COG0800	Aldolase
I6L36_13905	COG1609	Transcriptional regulator
I6L36_13915	COG4942	peptidase
I6L36_13920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L36_13925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L36_13930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L36_13935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L36_13940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L36_13940	COG0316	Belongs to the HesB IscA family
I6L36_13945	COG1040	competence protein
I6L36_13950	COG0596	Alpha beta hydrolase
I6L36_13965	COG2183	response to ionizing radiation
I6L36_13970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L36_13980	COG2205	protein histidine kinase activity
I6L36_13990	COG0051	transcription antitermination factor activity, RNA binding
I6L36_13995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L36_14000	COG0088	Forms part of the polypeptide exit tunnel
I6L36_14005	COG0089	rRNA binding
I6L36_14010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L36_14015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L36_14020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L36_14025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L36_14030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L36_14035	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L36_14040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L36_14045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L36_14050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L36_14055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L36_14060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L36_14065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L36_14070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L36_14075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L36_14080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L36_14085	COG1841	ribosomal large subunit assembly
I6L36_14090	COG0200	Binds to the 23S rRNA
I6L36_14095	COG0201	protein transport
I6L36_14100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L36_14105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L36_14110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L36_14115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L36_14120	COG0202	RNA polymerase activity
I6L36_14125	COG0203	ribosomal protein L17
I6L36_14175	COG3706	GGDEF domain
I6L36_14175	COG4251	negative regulation of phosphorylation
I6L36_14175	COG2203	Gaf domain
I6L36_14175	COG5001	Diguanylate cyclase
I6L36_14180	COG0784	Response regulator, receiver
I6L36_14180	COG0835	chemotaxis
I6L36_14185	COG0835	chemotaxis
I6L36_14190	COG0840	transmembrane signaling receptor activity
I6L36_14210	COG3655	Transcriptional regulator
I6L36_14270	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L36_14275	COG0583	DNA-binding transcription factor activity
I6L36_14280	COG4221	oxidoreductase activity
I6L36_14295	COG1770	oligopeptidase
I6L36_14300	COG2358	TRAP transporter, solute receptor (TAXI family
I6L36_14315	COG3714	YhhN family
I6L36_14330	COG0583	DNA-binding transcription factor activity
I6L36_14340	COG1301	dicarboxylic acid transport
I6L36_14350	COG2095	MarC family integral membrane protein
I6L36_14360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L36_14370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L36_14405	COG0742	ribosomal rna small subunit methyltransferase
I6L36_14410	COG0552	protein localization to endoplasmic reticulum
I6L36_14415	COG2884	Cell division ATP-binding protein ftsE
I6L36_14420	COG2177	Part of the ABC transporter FtsEX involved in
I6L36_14430	COG0288	reversible hydration of carbon dioxide
I6L36_14435	COG2188	Transcriptional regulator
I6L36_14440	COG1228	amidohydrolase
I6L36_14445	COG0010	Belongs to the arginase family
I6L36_14450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L36_14455	COG2986	histidine ammonia-lyase
I6L36_14460	COG0387	Pfam Sodium calcium exchanger
I6L36_14465	COG2200	EAL domain
I6L36_14515	COG3267	Type II secretory pathway component ExeA
I6L36_14515	COG3409	Peptidoglycan-binding domain 1 protein
I6L36_14525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L36_14530	COG1459	type II secretion system
I6L36_14575	COG1077	Cell shape determining protein MreB Mrl
I6L36_14580	COG1792	Involved in formation and maintenance of cell shape
I6L36_14585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L36_14590	COG0424	maF-like protein
I6L36_14595	COG1530	ribonuclease E activity
I6L36_14600	COG3164	Protein of unknown function
I6L36_14605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L36_14610	COG0312	modulator of DNA gyrase
I6L36_14625	COG0477	Major facilitator Superfamily
I6L36_14635	COG2321	neutral zinc metallopeptidase
I6L36_14670	COG0189	ligase activity
I6L36_14675	COG0642	Histidine kinase
I6L36_14680	COG0745	RESPONSE REGULATOR receiver
I6L36_14695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L36_14700	COG0352	thiamine-phosphate diphosphorylase activity
I6L36_14705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L36_14715	COG2022	thiamine diphosphate biosynthetic process
I6L36_14720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L36_14765	COG0110	maltose O-acetyltransferase activity
I6L36_14780	COG3932	Exopolysaccharide synthesis, ExoD
I6L36_14795	COG1733	regulation of RNA biosynthetic process
I6L36_14825	COG1494	fructose-1,6-bisphosphatase
I6L36_14830	COG3385	transposase activity
I6L36_14840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L36_14845	COG5007	Belongs to the BolA IbaG family
I6L36_14855	COG2854	intermembrane phospholipid transfer
I6L36_14860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L36_14865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L36_14870	COG1127	ABC transporter
I6L36_14875	COG0517	IMP dehydrogenase activity
I6L36_14875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L36_14880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L36_14890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L36_14895	COG1137	ATPase activity
I6L36_14900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L36_14910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_14915	COG1660	Displays ATPase and GTPase activities
I6L36_14920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_14940	COG3964	amidohydrolase
I6L36_14975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L36_14980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L36_14990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L36_14995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L36_15000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L36_15005	COG0723	plastoquinol--plastocyanin reductase activity
I6L36_15010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L36_15015	COG2857	Cytochrome c1
I6L36_15020	COG0625	glutathione transferase activity
I6L36_15025	COG2969	positive regulation of protein catabolic process
I6L36_15030	COG3385	transposase activity
I6L36_15035	COG2823	Periplasmic or secreted lipoprotein
I6L36_15040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L36_15045	COG0792	nuclease activity
I6L36_15050	COG3107	peptidoglycan biosynthetic process
I6L36_15055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L36_15065	COG2001	Belongs to the MraZ family
I6L36_15070	COG0275	rRNA processing
I6L36_15075	COG3116	cell division
I6L36_15080	COG0768	penicillin binding
I6L36_15085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L36_15090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L36_15095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L36_15100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L36_15105	COG0772	Belongs to the SEDS family
I6L36_15110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L36_15115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L36_15120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L36_15125	COG0849	cell division
I6L36_15130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L36_15135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L36_15145	COG0653	protein targeting
I6L36_15155	COG0494	nUDIX hydrolase
I6L36_15160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L36_15165	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L36_15180	COG1459	type II secretion system
I6L36_15185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L36_15210	COG2186	Transcriptional regulator
I6L36_15215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L36_15220	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L36_15225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L36_15235	COG0840	transmembrane signaling receptor activity
I6L36_15240	COG0840	transmembrane signaling receptor activity
I6L36_15245	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L36_15250	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L36_15255	COG2200	EAL domain
I6L36_15265	COG1280	lysine exporter protein (LysE YggA)
I6L36_15275	COG0523	cobalamin synthesis protein
I6L36_15285	COG0477	Major facilitator Superfamily
I6L36_15300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L36_15305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L36_15360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L36_15370	COG1546	Belongs to the CinA family
I6L36_15375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L36_15390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L36_15395	COG0527	aspartate kinase activity
I6L36_15400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L36_15435	COG1686	Belongs to the peptidase S11 family
I6L36_15440	COG0586	Pfam SNARE associated Golgi protein
I6L36_15445	COG1253	flavin adenine dinucleotide binding
I6L36_15450	COG0525	valine-tRNA ligase activity
I6L36_15455	COG2927	DNA polymerase III (CHI subunit)
I6L36_15460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L36_15465	COG0795	lipopolysaccharide-transporting ATPase activity
I6L36_15470	COG0795	lipopolysaccharide-transporting ATPase activity
I6L36_15485	COG4974	Belongs to the 'phage' integrase family
I6L36_15515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L36_15590	COG0004	ammonium transporteR
I6L36_15595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L36_15610	COG2165	general secretion pathway protein
I6L36_15615	COG0084	hydrolase, TatD family'
I6L36_15620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L36_15630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L36_15635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L36_15640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L36_15645	COG0813	purine-nucleoside phosphorylase activity
I6L36_15650	COG3447	MASE1 domain protein
I6L36_15650	COG5001	Diguanylate cyclase
I6L36_15650	COG5002	protein histidine kinase activity
I6L36_15660	COG0560	Phosphoserine phosphatase
I6L36_15675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L36_15685	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6L36_15690	COG0776	regulation of translation
I6L36_15705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L36_15710	COG0735	belongs to the Fur family
I6L36_15730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L36_15735	COG0513	Belongs to the DEAD box helicase family
I6L36_15740	COG3022	response to hydroperoxide
I6L36_15755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L36_15760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L36_15765	COG0762	integral membrane protein
I6L36_15770	COG1872	DUF167
I6L36_15790	COG3112	Uncharacterised protein family (UPF0231)
I6L36_15795	COG3835	regulator
I6L36_15800	COG2610	gluconate transmembrane transporter activity
I6L36_15805	COG1929	Belongs to the glycerate kinase type-1 family
I6L36_15820	COG0583	DNA-binding transcription factor activity
I6L36_15825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L36_15840	COG0347	Belongs to the P(II) protein family
I6L36_15845	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L36_15855	COG3842	ATPase activity
I6L36_15860	COG2837	iron assimilation
I6L36_15865	COG1438	arginine binding
I6L36_15870	COG1126	abc transporter atp-binding protein
I6L36_15875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_15880	COG4215	(ABC) transporter
I6L36_15885	COG4160	amino acid transport
I6L36_15890	COG0039	L-malate dehydrogenase activity
I6L36_15900	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L36_15905	COG1017	nitric oxide dioxygenase activity
I6L36_15905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L36_15920	COG4536	flavin adenine dinucleotide binding
I6L36_15925	COG4137	Cytochrome C assembly protein
I6L36_15930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L36_15935	COG0228	four-way junction DNA binding
I6L36_15940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L36_15945	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L36_15950	COG0335	large ribosomal subunit rRNA binding
I6L36_15970	COG1051	belongs to the nudix hydrolase family
I6L36_15980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L36_15985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L36_15990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L36_16000	COG0583	DNA-binding transcription factor activity
I6L36_16005	COG0640	Transcriptional regulator
I6L36_16010	COG0268	Binds directly to 16S ribosomal RNA
I6L36_16015	COG0728	peptidoglycan biosynthetic process
I6L36_16020	COG0196	riboflavin kinase activity
I6L36_16025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L36_16030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L36_16035	COG1047	Peptidyl-prolyl cis-trans
I6L36_16040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L36_16085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L36_16085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L36_16100	COG1854	S-ribosylhomocysteine lyase activity
I6L36_16105	COG3706	GGDEF domain
I6L36_16110	COG0557	exoribonuclease II activity
I6L36_16115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L36_16125	COG2153	protein acetylation
I6L36_16135	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L36_16140	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L36_16145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L36_16150	COG0359	binds to the 23S rRNA
I6L36_16190	COG1238	metal cluster binding
I6L36_16195	COG0612	Peptidase, M16
I6L36_16200	COG2918	glutathione biosynthetic process
I6L36_16205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L36_16210	COG1027	Aspartate ammonia-lyase
I6L36_16215	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L36_16220	COG0534	Mate efflux family protein
I6L36_16225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L36_16230	COG0459	protein refolding
I6L36_16250	COG0564	pseudouridine synthase activity
I6L36_16255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L36_16290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L36_16300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L36_16305	COG4208	sulfate ABC transporter
I6L36_16310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L36_16315	COG0583	DNA-binding transcription factor activity
I6L36_16320	COG3397	chitin binding
I6L36_16325	COG0840	transmembrane signaling receptor activity
I6L36_16350	COG1328	CTP reductase activity
I6L36_16355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L36_16375	COG1448	Aminotransferase
I6L36_16400	COG1215	transferase activity, transferring glycosyl groups
I6L36_16445	COG0513	Belongs to the DEAD box helicase family
I6L36_16460	COG4166	transmembrane transport
I6L36_16475	COG1024	Enoyl-CoA hydratase
I6L36_16490	COG4221	oxidoreductase activity
I6L36_16495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L36_16500	COG0442	prolyl-tRNA aminoacylation
I6L36_16505	COG0840	transmembrane signaling receptor activity
I6L36_16510	COG0632	four-way junction helicase activity
I6L36_16515	COG2255	four-way junction helicase activity
I6L36_16520	COG1271	oxidase subunit
I6L36_16525	COG1294	oxidase, subunit
I6L36_16530	COG4890	Cyd operon protein YbgT
I6L36_16535	COG3790	cyd operon protein YbgE
I6L36_16540	COG0824	Thioesterase
I6L36_16545	COG0811	peptide transport
I6L36_16560	COG0823	Involved in the tonB-independent uptake of proteins
I6L36_16565	COG2885	chlorophyll binding
I6L36_16570	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L36_16645	COG0840	transmembrane signaling receptor activity
I6L36_16650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L36_16660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L36_16665	COG1640	4-alpha-glucanotransferase
I6L36_16670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L36_16700	COG2130	NADP-dependent
I6L36_16705	COG1846	Transcriptional regulator
I6L36_16735	COG0561	phosphatase activity
I6L36_16750	COG0733	neurotransmitter:sodium symporter activity
I6L36_16755	COG0733	neurotransmitter:sodium symporter activity
I6L36_16770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L36_16790	COG1794	racemase activity, acting on amino acids and derivatives
I6L36_16800	COG1022	Amp-dependent synthetase and ligase
I6L36_16810	COG0456	acetyltransferase
I6L36_16825	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L36_16830	COG5002	protein histidine kinase activity
I6L36_16830	COG5001	Diguanylate cyclase
I6L36_16860	COG1902	pentaerythritol trinitrate reductase activity
I6L36_16875	COG2957	Belongs to the agmatine deiminase family
I6L36_16880	COG0154	amidase activity
I6L36_16890	COG0513	Belongs to the DEAD box helicase family
I6L36_16895	COG2199	diguanylate cyclase activity
I6L36_16895	COG2203	Gaf domain
I6L36_16930	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L36_16940	COG0577	efflux transmembrane transporter activity
I6L36_16940	COG1136	(ABC) transporter
I6L36_16945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_16950	COG0745	RESPONSE REGULATOR receiver
I6L36_16955	COG2205	protein histidine kinase activity
I6L36_17020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L36_17025	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L36_17030	COG1178	ABC-type Fe3 transport system permease component
I6L36_17035	COG4143	(ABC) transporter
I6L36_17050	COG0066	3-isopropylmalate dehydratase activity
I6L36_17055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L36_17060	COG0473	3-isopropylmalate dehydrogenase activity
I6L36_17065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L36_17090	COG0028	Belongs to the TPP enzyme family
I6L36_17095	COG0440	acetolactate synthase activity
I6L36_17100	COG0857	belongs to the CobB CobQ family
I6L36_17100	COG0280	phosphate acetyltransferase
I6L36_17105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L36_17115	COG3013	Belongs to the UPF0304 family
I6L36_17120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L36_17125	COG2716	regulation of RNA biosynthetic process
I6L36_17130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L36_17135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L36_17140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L36_17155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L36_17175	COG0784	Response regulator, receiver
I6L36_17175	COG2198	Histidine kinase
I6L36_17175	COG5002	protein histidine kinase activity
I6L36_17190	COG2205	protein histidine kinase activity
I6L36_17190	COG0784	Response regulator, receiver
I6L36_17210	COG1464	Belongs to the NlpA lipoprotein family
I6L36_17215	COG2011	ABC-type metal ion transport system permease component
I6L36_17220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L36_17240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L36_17240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L36_17245	COG0802	atpase or kinase
I6L36_17255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L36_17260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L36_17265	COG1923	regulation of RNA biosynthetic process
I6L36_17270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L36_17275	COG0330	HflC and HflK could
I6L36_17280	COG0330	HflC and HflK could
I6L36_17285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L36_17290	COG0142	geranyltranstransferase activity
I6L36_17295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L36_17300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L36_17305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L36_17310	COG3314	Sporulation integral membrane protein YlbJ
I6L36_17315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L36_17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L36_17330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L36_17335	COG2967	ApaG domain
I6L36_17340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L36_17345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L36_17355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L36_17360	COG3178	'Phosphotransferase
I6L36_17365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L36_17370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L36_17375	COG2252	PERMEase
I6L36_17385	COG0488	(ABC) transporter
I6L36_17390	COG0741	lytic transglycosylase activity
I6L36_17395	COG0463	Glycosyl transferase, family 2
I6L36_17405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L36_17430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L36_17440	COG3721	Heme iron utilization protein
I6L36_17445	COG0748	coenzyme F420 binding
I6L36_17470	COG2814	Major facilitator Superfamily
I6L36_17475	COG2205	protein histidine kinase activity
I6L36_17485	COG2226	methyltransferase
I6L36_17495	COG1765	OsmC-like protein
I6L36_17510	COG3954	Phosphoribulokinase
I6L36_17515	COG3089	Belongs to the UPF0270 family
I6L36_17520	COG5001	Diguanylate cyclase
I6L36_17520	COG2203	Gaf domain
I6L36_17520	COG3706	GGDEF domain
I6L36_17520	COG4251	negative regulation of phosphorylation
I6L36_17525	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L36_17530	COG0784	Response regulator, receiver
I6L36_17530	COG0835	chemotaxis
I6L36_17540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L36_17545	COG1047	Peptidyl-prolyl cis-trans
I6L36_17550	COG2900	Belongs to the SlyX family
I6L36_17560	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L36_17565	COG2204	response regulator
I6L36_17585	COG0737	Belongs to the 5'-nucleotidase family
I6L36_17600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L36_17605	COG0506	proline dehydrogenase activity
I6L36_17605	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L36_17605	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L36_17615	COG0114	fumarate hydratase activity
I6L36_17625	COG1966	Carbon starvation protein
I6L36_17630	COG3279	Response regulator of the LytR AlgR family
I6L36_17635	COG3275	phosphorelay sensor kinase activity
I6L36_17645	COG2203	Gaf domain
I6L36_17645	COG2200	EAL domain
I6L36_17645	COG2199	diguanylate cyclase activity
I6L36_17670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L36_17680	COG1280	lysine exporter protein (LysE YggA)
I6L36_17685	COG0826	peptidase U32
I6L36_17695	COG3813	Protein conserved in bacteria
I6L36_17715	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L36_17805	COG2610	gluconate transmembrane transporter activity
I6L36_17810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L36_17815	COG3622	Belongs to the hyi family
I6L36_17820	COG0235	Class ii aldolase
I6L36_17830	COG2084	Dehydrogenase
I6L36_17835	COG1349	DNA-binding transcription factor activity
I6L36_17845	COG2133	pyrroloquinoline quinone binding
I6L36_17890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L36_17925	COG1605	Chorismate mutase
I6L36_17925	COG0077	Prephenate dehydratase
I6L36_17950	COG3272	Protein of unknown function (DUF1722)
I6L36_17955	COG0789	Transcriptional regulator
I6L36_17960	COG0415	Belongs to the DNA photolyase family
I6L36_17970	COG4221	oxidoreductase activity
I6L36_17985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L36_18010	COG0783	Belongs to the Dps family
I6L36_18015	COG1151	hydroxylamine reductase activity
I6L36_18025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L36_18040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_18045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_18050	COG0745	RESPONSE REGULATOR receiver
I6L36_18055	COG5000	phosphorelay sensor kinase activity
I6L36_18055	COG5002	protein histidine kinase activity
I6L36_18060	COG0659	secondary active sulfate transmembrane transporter activity
I6L36_18070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L36_18075	COG1666	GTP binding
I6L36_18085	COG2211	Major facilitator Superfamily
I6L36_18095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L36_18105	COG2813	Specifically methylates the guanine in position
I6L36_18110	COG0271	Belongs to the BolA IbaG family
I6L36_18115	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L36_18120	COG1805	sodium ion transport
I6L36_18125	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L36_18130	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L36_18135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L36_18140	COG2871	sodium ion transport
I6L36_18145	COG1477	protein flavinylation
I6L36_18160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L36_18165	COG0840	transmembrane signaling receptor activity
I6L36_18170	COG0583	DNA-binding transcription factor activity
I6L36_18185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L36_18195	COG0473	3-isopropylmalate dehydrogenase activity
I6L36_18200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L36_18205	COG1611	Belongs to the LOG family
I6L36_18220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L36_18220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L36_18230	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L36_18255	COG3098	single-species biofilm formation
I6L36_18260	COG0564	pseudouridine synthase activity
I6L36_18275	COG4580	involved in the transport of maltose and maltodextrins
I6L36_18285	COG1263	PTS System
I6L36_18285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L36_18295	COG2171	N-acyltransferase activity
I6L36_18300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L36_18305	COG0024	Methionine aminopeptidase
I6L36_18310	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L36_18315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L36_18320	COG0528	UMP kinase activity
I6L36_18325	COG0233	cytoplasmic translational termination
I6L36_18330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L36_18335	COG0575	Belongs to the CDS family
I6L36_18340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L36_18345	COG0750	zinc metalloprotease
I6L36_18360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L36_18365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L36_18370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L36_18375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L36_18380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L36_18385	COG0587	DNA-directed DNA polymerase activity
I6L36_18390	COG0825	malonyl-CoA metabolic process
I6L36_18405	COG0814	amino acid
I6L36_18410	COG3385	transposase activity
I6L36_18415	COG0531	amino acid
I6L36_18425	COG0488	(ABC) transporter
I6L36_18435	COG3590	peptidase
I6L36_18440	COG0037	tRNA processing
I6L36_18445	COG3706	GGDEF domain
I6L36_18490	COG0366	Alpha amylase catalytic
I6L36_18505	COG0463	Glycosyl transferase, family 2
I6L36_18520	COG2989	Protein conserved in bacteria
I6L36_18525	COG3108	Peptidase M15
I6L36_18535	COG2860	membrane
I6L36_18545	COG1196	nuclear chromosome segregation
I6L36_18550	COG3115	cell septum assembly
I6L36_18570	COG0210	DNA helicase
I6L36_18615	COG2850	peptidyl-arginine hydroxylation
I6L36_18630	COG1595	DNA-templated transcription, initiation
I6L36_18645	COG3220	belongs to the UPF0276 family
I6L36_18690	COG0659	secondary active sulfate transmembrane transporter activity
I6L36_18720	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L36_18750	COG1328	CTP reductase activity
I6L36_18755	COG0602	queuosine metabolic process
I6L36_18780	COG1566	PFAM secretion protein HlyD family protein
I6L36_18790	COG3290	protein histidine kinase activity
I6L36_18810	COG0697	spore germination
I6L36_18825	COG3284	Transcriptional regulator
I6L36_18830	COG3706	GGDEF domain
I6L36_18835	COG0346	lactoylglutathione lyase activity
I6L36_18840	COG0745	RESPONSE REGULATOR receiver
I6L36_18845	COG5002	protein histidine kinase activity
I6L36_18855	COG4783	chaperone-mediated protein folding
I6L36_18865	COG1940	carbohydrate kinase activity
I6L36_18875	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L36_18895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_18900	COG4597	amino acid ABC transporter
I6L36_18905	COG0765	amino acid transport
I6L36_18910	COG1126	abc transporter atp-binding protein
I6L36_18920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L36_18925	COG0678	peroxiredoxin activity
I6L36_18935	COG0019	diaminopimelate decarboxylase activity
I6L36_18940	COG1115	amino acid carrier protein
I6L36_18945	COG0095	Lipoate-protein ligase
I6L36_18955	COG2233	PERMEase
I6L36_18970	COG0534	Mate efflux family protein
I6L36_18975	COG2207	Transcriptional regulator
I6L36_18980	COG0281	malic enzyme
I6L36_19010	COG0733	neurotransmitter:sodium symporter activity
I6L36_19015	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L36_19020	COG3706	GGDEF domain
I6L36_19035	COG1032	radical SAM domain protein
I6L36_19065	COG0673	inositol 2-dehydrogenase activity
I6L36_19070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L36_19080	COG1196	nuclear chromosome segregation
I6L36_19080	COG0741	lytic transglycosylase activity
I6L36_19080	COG0739	heme binding
I6L36_19105	COG0788	formyltetrahydrofolate deformylase activity
I6L36_19110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L36_19120	COG3118	belongs to the thioredoxin family
I6L36_19130	COG0791	NLP P60 protein
I6L36_19135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L36_19150	COG1376	ErfK ybiS ycfS ynhG family protein
I6L36_19150	COG1388	LysM domain
I6L36_19160	COG0784	Response regulator, receiver
I6L36_19160	COG2205	protein histidine kinase activity
I6L36_19185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_19185	COG2205	protein histidine kinase activity
I6L36_19190	COG3384	dioxygenase
I6L36_19200	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L36_19210	COG0531	amino acid
I6L36_19215	COG0531	amino acid
I6L36_19230	COG1012	belongs to the aldehyde dehydrogenase family
I6L36_19235	COG1396	sequence-specific DNA binding
I6L36_19235	COG1917	Cupin 2, conserved barrel domain protein
I6L36_19240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L36_19275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L36_19275	COG4651	solute:proton antiporter activity
I6L36_19290	COG2974	May be involved in recombination
I6L36_19295	COG1247	-acetyltransferase
I6L36_19300	COG0420	3'-5' exonuclease activity
I6L36_19310	COG3038	cytochrome b561
I6L36_19315	COG2190	(PTS) system
I6L36_19325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L36_19330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L36_19335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L36_19350	COG1720	tRNA m6t6A37 methyltransferase activity
I6L36_19370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L36_19375	COG4988	ABC transporter
I6L36_19390	COG0745	RESPONSE REGULATOR receiver
I6L36_19400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L36_19415	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L36_19420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L36_19430	COG0083	homoserine kinase activity
I6L36_19435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L36_19455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L36_19465	COG3220	belongs to the UPF0276 family
I6L36_19495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L36_19500	COG1289	transmembrane transporter activity
I6L36_19505	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6L36_19510	COG0746	molybdenum cofactor guanylyltransferase activity
I6L36_19515	COG0281	malic enzyme
I6L36_19550	COG1196	nuclear chromosome segregation
I6L36_19550	COG3264	Mechanosensitive ion channel
I6L36_19560	COG2850	peptidyl-arginine hydroxylation
I6L36_19565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L36_19570	COG2915	High frequency lysogenization protein hflD homolog
I6L36_19575	COG0482	sulfurtransferase activity
I6L36_19585	COG1187	pseudouridine synthase activity
I6L36_19590	COG0456	acetyltransferase
I6L36_19620	COG0538	isocitrate dehydrogenase activity
I6L36_19630	COG3048	D-serine ammonia-lyase activity
I6L36_19635	COG0583	DNA-binding transcription factor activity
I6L36_19640	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L36_19645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L36_19650	COG2375	cellular response to nickel ion
I6L36_19655	COG1538	Outer membrane efflux protein
I6L36_19660	COG0577	efflux transmembrane transporter activity
I6L36_19660	COG1136	(ABC) transporter
I6L36_19665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_19675	COG0497	DNA recombination
I6L36_19685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L36_19690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L36_19695	COG0443	Heat shock 70 kDa protein
I6L36_19700	COG0484	heat shock protein binding
I6L36_19730	COG1285	pathogenesis
I6L36_19740	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L36_19750	COG0640	Transcriptional regulator
I6L36_19780	COG0095	Lipoate-protein ligase
I6L36_19795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_19800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_19810	COG0708	Exodeoxyribonuclease III
I6L36_19820	COG0745	RESPONSE REGULATOR receiver
I6L36_19835	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6L36_19850	COG1846	Transcriptional regulator
I6L36_19870	COG0583	DNA-binding transcription factor activity
I6L36_19880	COG0675	Transposase, IS605 OrfB family
I6L36_19890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L36_19895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L36_19900	COG1845	cytochrome c oxidase, subunit III
I6L36_19905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L36_19910	COG0109	protoheme IX farnesyltransferase activity
I6L36_19915	COG2814	Major facilitator Superfamily
I6L36_19920	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6L36_19950	COG3550	peptidyl-serine autophosphorylation
I6L36_19955	COG1396	sequence-specific DNA binding
I6L36_19960	COG0159	tryptophan synthase activity
I6L36_19965	COG0133	tryptophan synthase activity
I6L36_19970	COG0134	indole-3-glycerol-phosphate synthase activity
I6L36_19970	COG0135	phosphoribosylanthranilate isomerase activity
I6L36_19975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L36_19980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L36_19980	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L36_19985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L36_19990	COG0613	PHP domain protein
I6L36_19995	COG0009	L-threonylcarbamoyladenylate synthase
I6L36_20005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L36_20015	COG1946	Acyl-CoA thioesterase
I6L36_20020	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L36_20030	COG1309	transcriptional regulator
I6L36_20035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L36_20040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_20055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L36_20070	COG0583	DNA-binding transcription factor activity
I6L36_20085	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L36_20095	COG1960	acyl-CoA dehydrogenase activity
I6L36_20100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L36_20110	COG0469	pyruvate kinase activity
I6L36_20115	COG1737	Transcriptional regulator
I6L36_20140	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L36_20190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L36_20200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L36_20220	COG1216	Glycosyl transferase, family 2
I6L36_20225	COG1216	Glycosyl transferase, family 2
I6L36_20255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L36_20280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L36_20290	COG3132	Protein of unknown function, DUF480
I6L36_20330	COG1278	Cold shock
I6L36_20370	COG4166	transmembrane transport
I6L36_20375	COG0697	spore germination
I6L36_20385	COG0675	Transposase, IS605 OrfB family
I6L36_20390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L36_20405	COG4166	transmembrane transport
I6L36_20415	COG0675	Transposase, IS605 OrfB family
I6L36_20420	COG0622	Phosphoesterase
I6L36_20435	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L36_20440	COG0784	Response regulator, receiver
I6L36_20440	COG0835	chemotaxis
I6L36_20445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L36_20450	COG1815	bacterial-type flagellum-dependent cell motility
I6L36_20465	COG1749	Flagellar hook protein flgE
I6L36_20480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L36_20485	COG1706	bacterial-type flagellum-dependent cell motility
I6L36_20490	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L36_20490	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L36_20505	COG2239	Acts as a magnesium transporter
I6L36_20515	COG0675	Transposase, IS605 OrfB family
I6L36_20530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L36_20535	COG2716	regulation of RNA biosynthetic process
I6L36_20560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L36_20565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L36_20570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L36_20575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L36_20595	COG0675	Transposase, IS605 OrfB family
I6L36_20605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L36_20620	COG0590	tRNA wobble adenosine to inosine editing
I6L36_20625	COG0573	inorganic phosphate transmembrane transporter activity
I6L36_20630	COG0581	inorganic phosphate transmembrane transporter activity
I6L36_20635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L36_20640	COG0704	Plays a role in the regulation of phosphate uptake
I6L36_20645	COG1253	flavin adenine dinucleotide binding
I6L36_20660	COG0531	amino acid
I6L36_20670	COG1126	abc transporter atp-binding protein
I6L36_20675	COG0765	amino acid transport
I6L36_20680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_20690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L36_20710	COG1785	Belongs to the alkaline phosphatase family
I6L36_20715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L36_20720	COG0477	Major facilitator Superfamily
I6L36_20725	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L36_20735	COG1199	ATP-dependent helicase activity
I6L36_20750	COG1448	Aminotransferase
I6L36_20755	COG0433	COG0433 Predicted ATPase
I6L36_20770	COG2333	competence protein COMEC
I6L36_20770	COG0658	competence protein
I6L36_20775	COG1132	(ABC) transporter
I6L36_20780	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L36_20785	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L36_20790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L36_20795	COG2197	response regulator
I6L36_20800	COG0322	excinuclease ABC activity
I6L36_20855	COG0604	alcohol dehydrogenase
I6L36_20860	COG1309	transcriptional regulator
I6L36_20865	COG2261	transglycosylase associated protein
I6L36_20870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L36_20880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L36_20900	COG3039	Transposase
I6L36_20905	COG2203	Gaf domain
I6L36_20905	COG2199	diguanylate cyclase activity
I6L36_20950	COG2119	membrane
I6L36_20955	COG0023	Translation Initiation Factor
I6L36_20965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L36_20990	COG4139	cobalamin transport
I6L36_20995	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L36_21000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L36_21005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L36_21010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L36_21015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L36_21020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L36_21030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L36_21035	COG0505	Belongs to the CarA family
I6L36_21040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L36_21045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L36_21050	COG3706	GGDEF domain
I6L36_21075	COG0513	Belongs to the DEAD box helicase family
I6L36_21085	COG4104	PAAR repeat-containing protein
I6L36_21110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L36_21115	COG0765	amino acid transport
I6L36_21120	COG1126	abc transporter atp-binding protein
I6L36_21125	COG0493	'glutamate synthase
I6L36_21130	COG0067	glutamate synthase
I6L36_21130	COG0069	glutamate synthase activity
I6L36_21130	COG0070	glutamate synthase
I6L36_21135	COG1242	4 iron, 4 sulfur cluster binding
I6L36_21195	COG1113	amino acid transport
I6L36_21205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L36_21210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L36_21210	COG0574	Belongs to the PEP-utilizing enzyme family
I6L36_21215	COG1119	ATPase activity
I6L36_21235	COG1464	Belongs to the NlpA lipoprotein family
I6L36_21245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L36_21250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L36_21260	COG0101	tRNA pseudouridine synthase activity
I6L36_21265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L36_21270	COG0285	dihydrofolate synthase activity
I6L36_21275	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L36_21280	COG2920	part of a sulfur-relay system
I6L36_21285	COG1289	transmembrane transporter activity
I6L36_21290	COG0670	Belongs to the BI1 family
I6L36_21325	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L36_21330	COG0840	transmembrane signaling receptor activity
I6L36_21335	COG5001	Diguanylate cyclase
I6L36_21340	COG0564	pseudouridine synthase activity
I6L36_21355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L36_21365	COG0625	glutathione transferase activity
I6L36_21380	COG0367	asparagine synthase
I6L36_21390	COG0647	UMP catabolic process
I6L36_21395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L36_21400	COG0604	alcohol dehydrogenase
I6L36_21405	COG1902	pentaerythritol trinitrate reductase activity
I6L36_21410	COG1253	flavin adenine dinucleotide binding
I6L36_21420	COG0247	lactate metabolic process
I6L36_21420	COG0277	FAD linked oxidase domain protein
I6L36_21430	COG2050	protein possibly involved in aromatic compounds catabolism
I6L36_21445	COG5001	Diguanylate cyclase
I6L36_21450	COG0583	DNA-binding transcription factor activity
I6L36_21455	COG2814	Major facilitator Superfamily
I6L36_21460	COG2056	Na+-H+ antiporter family
I6L36_21465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L36_21480	COG0483	inositol monophosphate 1-phosphatase activity
I6L36_21490	COG0625	glutathione transferase activity
I6L36_21495	COG0625	glutathione transferase activity
I6L36_21505	COG0601	transmembrane transport
I6L36_21510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L36_21515	COG0444	Belongs to the ABC transporter superfamily
I6L36_21520	COG2814	Major facilitator Superfamily
I6L36_21540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L36_21545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L36_21550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L36_21555	COG0509	glycine decarboxylation via glycine cleavage system
I6L36_21560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L36_21560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L36_21585	COG3634	alkyl hydroperoxide reductase activity
I6L36_21590	COG0450	alkyl hydroperoxide reductase
I6L36_21595	COG0517	IMP dehydrogenase activity
I6L36_21600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L36_21605	COG0343	queuine tRNA-ribosyltransferase activity
I6L36_21610	COG1862	Preprotein translocase
I6L36_21615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L36_21620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L36_21625	COG2897	thiosulfate sulfurtransferase activity
I6L36_21635	COG0826	peptidase U32
I6L36_21640	COG0826	peptidase U32
I6L36_21645	COG3154	lipid carrier protein
I6L36_21660	COG1104	cysteine desulfurase activity
I6L36_21665	COG0822	iron-sulfur transferase activity
I6L36_21675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L36_21680	COG0443	Heat shock 70 kDa protein
I6L36_21685	COG0633	Ferredoxin
I6L36_21695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L36_21700	COG0105	UTP biosynthetic process
I6L36_21705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L36_21715	COG1426	Protein conserved in bacteria
I6L36_21725	COG0124	histidyl-tRNA synthetase
I6L36_21730	COG2976	Protein conserved in bacteria
I6L36_21735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L36_21740	COG1160	GTP binding
I6L36_21745	COG1645	bacterial-type flagellum-dependent swarming motility
I6L36_21750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L36_21755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L36_21755	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L36_21765	COG1007	ATP synthesis coupled electron transport
I6L36_21770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient