locus-tag	class	description
I6L37_00010	COG0569	domain protein
I6L37_00010	COG2985	domain, Protein
I6L37_00015	COG1272	protein, Hemolysin III
I6L37_00020	COG0076	glutamate decarboxylase activity
I6L37_00025	COG2917	probably involved in intracellular septation
I6L37_00030	COG2350	Protein conserved in bacteria
I6L37_00050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L37_00055	COG1381	Involved in DNA repair and RecF pathway recombination
I6L37_00065	COG0571	ribonuclease III activity
I6L37_00070	COG0681	Belongs to the peptidase S26 family
I6L37_00075	COG0481	GTPase activity
I6L37_00085	COG3026	antisigma factor binding
I6L37_00090	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L37_00095	COG1595	DNA-templated transcription, initiation
I6L37_00100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L37_00110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L37_00120	COG0583	DNA-binding transcription factor activity
I6L37_00150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_00160	COG0126	phosphoglycerate kinase activity
I6L37_00165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L37_00170	COG1940	carbohydrate kinase activity
I6L37_00175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L37_00180	COG2816	NAD+ diphosphatase activity
I6L37_00185	COG0506	proline dehydrogenase activity
I6L37_00185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L37_00185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L37_00190	COG4991	sh3 domain protein
I6L37_00195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L37_00205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L37_00210	COG0840	transmembrane signaling receptor activity
I6L37_00220	COG1278	Cold shock
I6L37_00260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L37_00270	COG0688	phosphatidylethanolamine metabolic process
I6L37_00275	COG4628	conserved protein (DUF2132)
I6L37_00285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L37_00290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6L37_00300	COG1073	alpha beta
I6L37_00305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L37_00310	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L37_00315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L37_00320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L37_00330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L37_00340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L37_00345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L37_00350	COG2967	ApaG domain
I6L37_00355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L37_00365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L37_00370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L37_00375	COG0318	PFAM AMP-dependent synthetase and ligase
I6L37_00380	COG3314	Sporulation integral membrane protein YlbJ
I6L37_00385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L37_00390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L37_00395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L37_00400	COG0142	geranyltranstransferase activity
I6L37_00405	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L37_00410	COG0330	HflC and HflK could
I6L37_00415	COG0330	HflC and HflK could
I6L37_00420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L37_00425	COG1923	regulation of RNA biosynthetic process
I6L37_00430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L37_00435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L37_00445	COG0802	atpase or kinase
I6L37_00450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L37_00450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L37_00475	COG2011	ABC-type metal ion transport system permease component
I6L37_00480	COG1464	Belongs to the NlpA lipoprotein family
I6L37_00490	COG0840	transmembrane signaling receptor activity
I6L37_00500	COG2205	protein histidine kinase activity
I6L37_00500	COG0784	Response regulator, receiver
I6L37_00515	COG5002	protein histidine kinase activity
I6L37_00515	COG2198	Histidine kinase
I6L37_00515	COG0784	Response regulator, receiver
I6L37_00540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L37_00545	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L37_00550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L37_00555	COG2716	regulation of RNA biosynthetic process
I6L37_00560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L37_00565	COG3013	Belongs to the UPF0304 family
I6L37_00575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L37_00580	COG0280	phosphate acetyltransferase
I6L37_00580	COG0857	belongs to the CobB CobQ family
I6L37_00585	COG1555	photosystem II stabilization
I6L37_00590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L37_00595	COG3104	oligopeptide transport
I6L37_00600	COG0745	RESPONSE REGULATOR receiver
I6L37_00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_00650	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L37_00685	COG0440	acetolactate synthase activity
I6L37_00690	COG0028	Belongs to the TPP enzyme family
I6L37_00715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L37_00720	COG0473	3-isopropylmalate dehydrogenase activity
I6L37_00725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L37_00730	COG0066	3-isopropylmalate dehydratase activity
I6L37_00745	COG4143	(ABC) transporter
I6L37_00750	COG1178	ABC-type Fe3 transport system permease component
I6L37_00755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L37_00765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L37_00815	COG0459	protein refolding
I6L37_00820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L37_00825	COG0534	Mate efflux family protein
I6L37_00830	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L37_00835	COG1027	Aspartate ammonia-lyase
I6L37_00840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L37_00845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L37_00850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L37_00855	COG1610	YqeY-like protein
I6L37_00865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L37_00900	COG0561	phosphatase activity
I6L37_00915	COG0733	neurotransmitter:sodium symporter activity
I6L37_00925	COG0733	neurotransmitter:sodium symporter activity
I6L37_00990	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L37_00995	COG2885	chlorophyll binding
I6L37_01000	COG0823	Involved in the tonB-independent uptake of proteins
I6L37_01015	COG0811	peptide transport
I6L37_01020	COG0824	Thioesterase
I6L37_01025	COG3790	cyd operon protein YbgE
I6L37_01030	COG4890	Cyd operon protein YbgT
I6L37_01035	COG1294	oxidase, subunit
I6L37_01045	COG2255	four-way junction helicase activity
I6L37_01050	COG0632	four-way junction helicase activity
I6L37_01055	COG0840	transmembrane signaling receptor activity
I6L37_01070	COG2771	luxR family
I6L37_01085	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L37_01090	COG4251	negative regulation of phosphorylation
I6L37_01090	COG5001	Diguanylate cyclase
I6L37_01090	COG2203	Gaf domain
I6L37_01090	COG3706	GGDEF domain
I6L37_01100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_01110	COG2995	paraquat-inducible protein a
I6L37_01115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L37_01115	COG3008	intermembrane lipid transfer
I6L37_01125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L37_01130	COG0442	prolyl-tRNA aminoacylation
I6L37_01135	COG4221	oxidoreductase activity
I6L37_01150	COG1024	Enoyl-CoA hydratase
I6L37_01165	COG2204	response regulator
I6L37_01170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L37_01175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6L37_01180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6L37_01190	COG4166	transmembrane transport
I6L37_01200	COG0840	transmembrane signaling receptor activity
I6L37_01205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L37_01210	COG0735	belongs to the Fur family
I6L37_01230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L37_01235	COG0513	Belongs to the DEAD box helicase family
I6L37_01240	COG2153	protein acetylation
I6L37_01250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L37_01255	COG0557	exoribonuclease II activity
I6L37_01260	COG3706	GGDEF domain
I6L37_01270	COG3240	lipase activity
I6L37_01275	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L37_01285	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L37_01290	COG1194	a g-specific adenine glycosylase
I6L37_01295	COG0617	tRNA 3'-terminal CCA addition
I6L37_01315	COG0347	Belongs to the P(II) protein family
I6L37_01335	COG3022	response to hydroperoxide
I6L37_01350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L37_01355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L37_01360	COG0762	integral membrane protein
I6L37_01365	COG1872	DUF167
I6L37_01375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L37_01380	COG0583	DNA-binding transcription factor activity
I6L37_01395	COG1929	Belongs to the glycerate kinase type-1 family
I6L37_01400	COG2610	gluconate transmembrane transporter activity
I6L37_01405	COG3835	regulator
I6L37_01410	COG3112	Uncharacterised protein family (UPF0231)
I6L37_01425	COG0513	Belongs to the DEAD box helicase family
I6L37_01450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L37_01455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L37_01465	COG1051	belongs to the nudix hydrolase family
I6L37_01470	COG3066	DNA modification
I6L37_01480	COG0335	large ribosomal subunit rRNA binding
I6L37_01485	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L37_01490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L37_01495	COG0228	four-way junction DNA binding
I6L37_01500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L37_01505	COG4137	Cytochrome C assembly protein
I6L37_01510	COG4536	flavin adenine dinucleotide binding
I6L37_01520	COG1017	nitric oxide dioxygenase activity
I6L37_01520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L37_01525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L37_01530	COG0039	L-malate dehydrogenase activity
I6L37_01535	COG4160	amino acid transport
I6L37_01540	COG4215	(ABC) transporter
I6L37_01545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L37_01550	COG1126	abc transporter atp-binding protein
I6L37_01555	COG1438	arginine binding
I6L37_01560	COG2837	iron assimilation
I6L37_01565	COG3842	ATPase activity
I6L37_01575	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L37_01590	COG1448	Aminotransferase
I6L37_01605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L37_01610	COG1328	CTP reductase activity
I6L37_01625	COG0628	permease
I6L37_01680	COG1215	transferase activity, transferring glycosyl groups
I6L37_01685	COG0726	polysaccharide deacetylase
I6L37_01685	COG1649	PFAM Uncharacterised BCR, COG1649
I6L37_01700	COG1215	transferase activity, transferring glycosyl groups
I6L37_01720	COG4783	chaperone-mediated protein folding
I6L37_01725	COG1215	transferase activity, transferring glycosyl groups
I6L37_01735	COG1215	transferase activity, transferring glycosyl groups
I6L37_01740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L37_01750	COG0840	transmembrane signaling receptor activity
I6L37_01755	COG3397	chitin binding
I6L37_01760	COG0583	DNA-binding transcription factor activity
I6L37_01765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L37_01770	COG4208	sulfate ABC transporter
I6L37_01775	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L37_01785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L37_01790	COG3174	membrane
I6L37_01795	COG0110	maltose O-acetyltransferase activity
I6L37_01810	COG1011	Hydrolase
I6L37_01815	COG0494	nUDIX hydrolase
I6L37_01820	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L37_01825	COG0814	amino acid
I6L37_01830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L37_01840	COG0626	cystathionine gamma-synthase activity
I6L37_01845	COG0527	aspartate kinase activity
I6L37_01845	COG0460	homoserine dehydrogenase
I6L37_01850	COG0306	phosphate transporter
I6L37_01855	COG1392	Phosphate transport regulator
I6L37_01865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L37_01870	COG2813	Specifically methylates the guanine in position
I6L37_01875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L37_01880	COG0297	glycogen (starch) synthase activity
I6L37_01920	COG1757	Na H antiporter
I6L37_01925	COG0316	Belongs to the HesB IscA family
I6L37_01935	COG0038	chloride channel
I6L37_01940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L37_01955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L37_01955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L37_02000	COG1396	sequence-specific DNA binding
I6L37_02005	COG3135	benzoate transporter
I6L37_02025	COG0840	transmembrane signaling receptor activity
I6L37_02030	COG3047	cAMP biosynthetic process
I6L37_02040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L37_02055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6L37_02065	COG1278	Cold shock
I6L37_02070	COG2252	PERMEase
I6L37_02075	COG2376	Dihydroxyacetone kinase
I6L37_02080	COG1461	Dihydroxyacetone kinase
I6L37_02085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L37_02085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_02085	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L37_02095	COG3284	Transcriptional regulator
I6L37_02105	COG2801	Transposase and inactivated derivatives
I6L37_02110	COG0628	permease
I6L37_02130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L37_02135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L37_02155	COG0456	acetyltransferase
I6L37_02160	COG3133	Outer membrane lipoprotein
I6L37_02165	COG0004	ammonium transporteR
I6L37_02170	COG1733	regulation of RNA biosynthetic process
I6L37_02180	COG3932	Exopolysaccharide synthesis, ExoD
I6L37_02185	COG0814	amino acid
I6L37_02215	COG3706	GGDEF domain
I6L37_02250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L37_02255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L37_02275	COG0477	Major facilitator Superfamily
I6L37_02280	COG0523	cobalamin synthesis protein
I6L37_02320	COG0477	Major facilitator Superfamily
I6L37_02335	COG0312	modulator of DNA gyrase
I6L37_02340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L37_02345	COG3164	Protein of unknown function
I6L37_02350	COG1530	ribonuclease E activity
I6L37_02355	COG0424	maF-like protein
I6L37_02360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L37_02365	COG1792	Involved in formation and maintenance of cell shape
I6L37_02370	COG1077	Cell shape determining protein MreB Mrl
I6L37_02400	COG4969	Belongs to the N-Me-Phe pilin family
I6L37_02405	COG2165	general secretion pathway protein
I6L37_02415	COG1459	type II secretion system
I6L37_02420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L37_02430	COG3267	Type II secretory pathway component ExeA
I6L37_02430	COG3409	Peptidoglycan-binding domain 1 protein
I6L37_02465	COG2199	diguanylate cyclase activity
I6L37_02465	COG2200	EAL domain
I6L37_02475	COG2200	EAL domain
I6L37_02480	COG0387	Pfam Sodium calcium exchanger
I6L37_02485	COG2986	histidine ammonia-lyase
I6L37_02490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L37_02495	COG0010	Belongs to the arginase family
I6L37_02500	COG1228	amidohydrolase
I6L37_02505	COG3314	Sporulation integral membrane protein YlbJ
I6L37_02515	COG0288	reversible hydration of carbon dioxide
I6L37_02525	COG2177	Part of the ABC transporter FtsEX involved in
I6L37_02530	COG2884	Cell division ATP-binding protein ftsE
I6L37_02535	COG0552	protein localization to endoplasmic reticulum
I6L37_02540	COG0742	ribosomal rna small subunit methyltransferase
I6L37_02565	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L37_02570	COG0583	DNA-binding transcription factor activity
I6L37_02575	COG4221	oxidoreductase activity
I6L37_02590	COG1770	oligopeptidase
I6L37_02605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L37_02610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L37_02620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L37_02630	COG2095	MarC family integral membrane protein
I6L37_02640	COG1301	dicarboxylic acid transport
I6L37_02665	COG3714	YhhN family
I6L37_02715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L37_02720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L37_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L37_02730	COG0049	tRNA binding
I6L37_02735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L37_02740	COG2168	tRNA wobble position uridine thiolation
I6L37_02760	COG2964	Protein conserved in bacteria
I6L37_02765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L37_02770	COG0085	RNA polymerase activity
I6L37_02775	COG0222	ribosome binding
I6L37_02780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L37_02785	COG0081	regulation of translation
I6L37_02790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L37_02795	COG0250	Participates in transcription elongation, termination and antitermination
I6L37_02810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L37_02840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L37_02845	COG0569	domain protein
I6L37_02850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L37_02880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L37_02880	COG4191	Histidine kinase
I6L37_02885	COG3005	denitrification pathway
I6L37_02890	COG0243	molybdopterin cofactor binding
I6L37_02935	COG2204	response regulator
I6L37_02945	COG2205	protein histidine kinase activity
I6L37_02960	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_02965	COG0517	IMP dehydrogenase activity
I6L37_02965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L37_02965	COG0617	tRNA 3'-terminal CCA addition
I6L37_02970	COG5413	integral membrane protein
I6L37_02980	COG1522	sequence-specific DNA binding
I6L37_02985	COG2502	aspartate--ammonia ligase
I6L37_02990	COG0542	response to heat
I6L37_03000	COG0564	pseudouridine synthase activity
I6L37_03005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L37_03010	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L37_03020	COG3681	Belongs to the UPF0597 family
I6L37_03025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L37_03030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L37_03035	COG1979	alcohol dehydrogenase
I6L37_03040	COG2207	Transcriptional regulator
I6L37_03045	COG3040	lipid binding
I6L37_03065	COG0540	Belongs to the ATCase OTCase family
I6L37_03070	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L37_03075	COG1438	arginine binding
I6L37_03080	COG1288	antiporter activity
I6L37_03085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L37_03120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L37_03130	COG3078	GTPase activator activity
I6L37_03145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L37_03155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L37_03160	COG0408	coproporphyrinogen oxidase activity
I6L37_03165	COG0009	L-threonylcarbamoyladenylate synthase
I6L37_03170	COG0551	DNA topoisomerase type I activity
I6L37_03175	COG2922	Belongs to the Smg family
I6L37_03180	COG0758	DNA mediated transformation
I6L37_03185	COG1652	LysM domain
I6L37_03190	COG0242	peptide deformylase activity
I6L37_03195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L37_03200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L37_03200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L37_03205	COG0569	domain protein
I6L37_03210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L37_03215	COG1217	gtp-binding protein TYPA
I6L37_03220	COG0174	glutamine synthetase
I6L37_03230	COG3852	Histidine kinase
I6L37_03235	COG2204	response regulator
I6L37_03240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L37_03270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L37_03280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L37_03280	COG0519	Catalyzes the synthesis of GMP from XMP
I6L37_03290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L37_03295	COG1396	sequence-specific DNA binding
I6L37_03300	COG1012	belongs to the aldehyde dehydrogenase family
I6L37_03310	COG2962	Rard protein
I6L37_03320	COG1280	lysine exporter protein (LysE YggA)
I6L37_03325	COG2391	methyltransferase activity
I6L37_03335	COG1309	transcriptional regulator
I6L37_03350	COG0129	dihydroxy-acid dehydratase activity
I6L37_03360	COG3978	acetolactate synthase activity
I6L37_03370	COG0606	chelatase, subunit chli
I6L37_03375	COG0204	Acyl-transferase
I6L37_03380	COG0204	Acyl-transferase
I6L37_03385	COG1683	Conserved Protein
I6L37_03395	COG1335	isochorismatase
I6L37_03405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L37_03410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6L37_03415	COG3639	organic phosphonate transmembrane transporter activity
I6L37_03420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L37_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L37_03435	COG3084	Protein conserved in bacteria
I6L37_03440	COG2203	Gaf domain
I6L37_03440	COG3706	GGDEF domain
I6L37_03440	COG4251	negative regulation of phosphorylation
I6L37_03440	COG5001	Diguanylate cyclase
I6L37_03445	COG0789	Transcriptional regulator
I6L37_03455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L37_03460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L37_03465	COG1561	YicC-like family, N-terminal region
I6L37_03470	COG0583	DNA-binding transcription factor activity
I6L37_03490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L37_03495	COG0385	Bile acid
I6L37_03500	COG0531	amino acid
I6L37_03505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L37_03510	COG0531	amino acid
I6L37_03515	COG2731	YhcH YjgK YiaL family protein
I6L37_03520	COG3250	beta-galactosidase activity
I6L37_03525	COG1609	Transcriptional regulator
I6L37_03560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L37_03565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L37_03565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L37_03570	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L37_03575	COG3074	FtsZ-dependent cytokinesis
I6L37_03585	COG1045	serine acetyltransferase
I6L37_03595	COG0745	RESPONSE REGULATOR receiver
I6L37_03600	COG2205	protein histidine kinase activity
I6L37_03605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L37_03610	COG0534	Mate efflux family protein
I6L37_03620	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L37_03625	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L37_03630	COG3845	ABC transporter
I6L37_03635	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L37_03640	COG0210	DNA helicase
I6L37_03710	COG3306	glycosyltransferase involved in LPS biosynthesis
I6L37_03725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L37_03735	COG0156	8-amino-7-oxononanoate synthase activity
I6L37_03740	COG1063	alcohol dehydrogenase
I6L37_03745	COG3245	cytochrome
I6L37_03760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L37_03765	COG2166	iron-sulfur cluster assembly
I6L37_03770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L37_03805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L37_03815	COG0583	DNA-binding transcription factor activity
I6L37_03830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L37_03835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L37_03840	COG2223	nitrite transmembrane transporter activity
I6L37_03845	COG3279	Response regulator of the LytR AlgR family
I6L37_03850	COG3275	phosphorelay sensor kinase activity
I6L37_03860	COG2081	HI0933 family
I6L37_03865	COG1528	Iron-storage protein
I6L37_03870	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L37_03875	COG0589	response to stress
I6L37_03915	COG3642	lipopolysaccharide core region biosynthetic process
I6L37_03920	COG0859	PFAM glycosyl transferase family 9
I6L37_03930	COG1758	RNA polymerase activity
I6L37_03935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L37_03940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L37_03950	COG2267	carboxylic ester hydrolase activity
I6L37_03955	COG0561	phosphatase activity
I6L37_03985	COG2271	Major facilitator Superfamily
I6L37_03990	COG0469	pyruvate kinase activity
I6L37_04020	COG1309	transcriptional regulator
I6L37_04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_04030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L37_04040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L37_04055	COG3118	belongs to the thioredoxin family
I6L37_04060	COG0513	Belongs to the DEAD box helicase family
I6L37_04065	COG0248	Ppx GppA phosphatase
I6L37_04075	COG0742	ribosomal rna small subunit methyltransferase
I6L37_04095	COG0084	hydrolase, TatD family'
I6L37_04100	COG0805	protein transport
I6L37_04105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L37_04115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L37_04120	COG3165	ubiquinone biosynthetic process from chorismate
I6L37_04130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L37_04135	COG0402	S-adenosylhomocysteine deaminase activity
I6L37_04140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L37_04175	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L37_04180	COG0848	biopolymer transport protein
I6L37_04185	COG0811	peptide transport
I6L37_04190	COG0811	peptide transport
I6L37_04200	COG2771	luxR family
I6L37_04210	COG1349	DNA-binding transcription factor activity
I6L37_04215	COG0745	RESPONSE REGULATOR receiver
I6L37_04220	COG2205	protein histidine kinase activity
I6L37_04225	COG4452	Inner membrane protein CreD
I6L37_04230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L37_04235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L37_04240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L37_04245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L37_04250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L37_04255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L37_04260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L37_04270	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L37_04280	COG1475	DNA binding
I6L37_04285	COG1192	Involved in chromosome partitioning
I6L37_04290	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L37_04295	COG0445	tRNA wobble uridine modification
I6L37_04300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L37_04310	COG4615	Cyclic peptide transporter
I6L37_04315	COG1120	ATPase activity
I6L37_04320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L37_04335	COG1902	pentaerythritol trinitrate reductase activity
I6L37_04340	COG1280	lysine exporter protein (LysE YggA)
I6L37_04345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L37_04350	COG0706	membrane insertase activity
I6L37_04355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L37_04360	COG0594	ribonuclease P activity
I6L37_04365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L37_04370	COG1126	abc transporter atp-binding protein
I6L37_04385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L37_04390	COG0592	DNA-directed DNA polymerase activity
I6L37_04400	COG0187	DNA topoisomerase II activity
I6L37_04410	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L37_04415	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L37_04420	COG3977	Valine--pyruvate aminotransferase
I6L37_04435	COG2814	Major facilitator Superfamily
I6L37_04440	COG0745	RESPONSE REGULATOR receiver
I6L37_04445	COG2205	protein histidine kinase activity
I6L37_04465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L37_04475	COG2960	long-chain fatty acid transporting porin activity
I6L37_04485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L37_04520	COG0683	leucine binding
I6L37_04525	COG1609	Transcriptional regulator
I6L37_04530	COG0348	domain, Protein
I6L37_04535	COG0814	amino acid
I6L37_04550	COG1609	Transcriptional regulator
I6L37_04565	COG2188	Transcriptional regulator
I6L37_04570	COG0348	domain, Protein
I6L37_04585	COG0751	glycine-tRNA ligase activity
I6L37_04590	COG0752	glycyl-tRNA synthetase alpha subunit
I6L37_04595	COG2818	Glycosylase
I6L37_04600	COG2885	chlorophyll binding
I6L37_04605	COG0251	oxidation-reduction process
I6L37_04610	COG0425	Belongs to the sulfur carrier protein TusA family
I6L37_04635	COG0183	Belongs to the thiolase family
I6L37_04640	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L37_04640	COG1024	Enoyl-CoA hydratase
I6L37_04645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L37_04650	COG0006	proline dipeptidase activity
I6L37_04655	COG1739	Uncharacterized protein family UPF0029
I6L37_04660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L37_04665	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L37_04715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L37_04720	COG0166	Belongs to the GPI family
I6L37_04725	COG0668	transmembrane transport
I6L37_04730	COG1309	transcriptional regulator
I6L37_04735	COG0756	dUTP diphosphatase activity
I6L37_04740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L37_04745	COG2003	Belongs to the UPF0758 family
I6L37_04750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L37_04755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L37_04765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L37_04770	COG2990	Protein conserved in bacteria
I6L37_04775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L37_04780	COG0859	PFAM glycosyl transferase family 9
I6L37_04785	COG0463	Glycosyl transferase, family 2
I6L37_04790	COG0859	PFAM glycosyl transferase family 9
I6L37_04795	COG1519	Transferase
I6L37_04800	COG0604	alcohol dehydrogenase
I6L37_04815	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L37_04820	COG3161	chorismate lyase activity
I6L37_04825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L37_04830	COG2937	Belongs to the GPAT DAPAT family
I6L37_04835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L37_04845	COG2239	Acts as a magnesium transporter
I6L37_04850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L37_04850	COG1648	precorrin-2 dehydrogenase activity
I6L37_04855	COG2116	formate transmembrane transporter activity
I6L37_04865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L37_04870	COG0842	Transport permease protein
I6L37_04875	COG0842	Transport permease protein
I6L37_04880	COG1131	(ABC) transporter
I6L37_04885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_04895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L37_04900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L37_04910	COG0018	arginyl-trna synthetase
I6L37_04915	COG1968	undecaprenyl-diphosphatase activity
I6L37_04920	COG2017	converts alpha-aldose to the beta-anomer
I6L37_04945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L37_04950	COG1609	Transcriptional regulator
I6L37_04955	COG3250	beta-galactosidase activity
I6L37_04975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L37_04990	COG0366	Alpha amylase catalytic
I6L37_05005	COG4310	Domain of unknown function (DUF2172)
I6L37_05015	COG0443	Heat shock 70 kDa protein
I6L37_05020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L37_05025	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_05030	COG3045	CreA protein
I6L37_05045	COG0174	glutamine synthetase
I6L37_05065	COG3842	ATPase activity
I6L37_05070	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L37_05075	COG1177	transmembrane transport
I6L37_05080	COG2258	MOSC domain
I6L37_05095	COG2050	protein possibly involved in aromatic compounds catabolism
I6L37_05100	COG0514	ATP-dependent DNA helicase (RecQ)
I6L37_05110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L37_05120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L37_05125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L37_05135	COG0254	rRNA binding
I6L37_05140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L37_05150	COG0702	epimerase
I6L37_05155	COG0281	malic enzyme
I6L37_05160	COG1295	ribonuclease BN
I6L37_05165	COG1490	D-aminoacyl-tRNA deacylase activity
I6L37_05170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L37_05175	COG0456	acetyltransferase
I6L37_05185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L37_05190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L37_05195	COG2610	gluconate transmembrane transporter activity
I6L37_05200	COG3265	gluconokinase activity
I6L37_05205	COG0129	dihydroxy-acid dehydratase activity
I6L37_05210	COG0800	Aldolase
I6L37_05215	COG1609	Transcriptional regulator
I6L37_05225	COG4942	peptidase
I6L37_05230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L37_05235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L37_05240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L37_05245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L37_05250	COG0316	Belongs to the HesB IscA family
I6L37_05250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L37_05255	COG1040	competence protein
I6L37_05260	COG0596	Alpha beta hydrolase
I6L37_05280	COG2183	response to ionizing radiation
I6L37_05285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L37_05295	COG2205	protein histidine kinase activity
I6L37_05305	COG0051	transcription antitermination factor activity, RNA binding
I6L37_05310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L37_05315	COG0088	Forms part of the polypeptide exit tunnel
I6L37_05320	COG0089	rRNA binding
I6L37_05325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L37_05330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L37_05335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L37_05340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L37_05345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L37_05350	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L37_05355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L37_05360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L37_05365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L37_05370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L37_05375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L37_05380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L37_05385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L37_05390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L37_05395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L37_05400	COG1841	ribosomal large subunit assembly
I6L37_05405	COG0200	Binds to the 23S rRNA
I6L37_05410	COG0201	protein transport
I6L37_05415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L37_05420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L37_05425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L37_05430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L37_05435	COG0202	RNA polymerase activity
I6L37_05440	COG0203	ribosomal protein L17
I6L37_05470	COG4771	TonB-dependent receptor
I6L37_05490	COG0583	DNA-binding transcription factor activity
I6L37_05500	COG1741	Belongs to the pirin family
I6L37_05505	COG2259	Doxx family
I6L37_05510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L37_05515	COG1074	ATP-dependent DNA helicase activity
I6L37_05520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L37_05535	COG0346	lactoylglutathione lyase activity
I6L37_05550	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L37_05575	COG1175	transmembrane transport
I6L37_05585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L37_05595	COG2203	Gaf domain
I6L37_05595	COG2199	diguanylate cyclase activity
I6L37_05610	COG2873	o-acetylhomoserine
I6L37_05620	COG4533	DNA binding
I6L37_05640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L37_05665	COG0753	catalase activity
I6L37_05670	COG1247	-acetyltransferase
I6L37_05685	COG0525	valine-tRNA ligase activity
I6L37_05690	COG2927	DNA polymerase III (CHI subunit)
I6L37_05695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L37_05700	COG0795	lipopolysaccharide-transporting ATPase activity
I6L37_05705	COG0795	lipopolysaccharide-transporting ATPase activity
I6L37_05790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L37_05840	COG4695	Portal protein
I6L37_05975	COG4974	Belongs to the 'phage' integrase family
I6L37_06005	COG1686	Belongs to the peptidase S11 family
I6L37_06015	COG1494	fructose-1,6-bisphosphatase
I6L37_06030	COG2959	enzyme of heme biosynthesis
I6L37_06040	COG0181	hydroxymethylbilane synthase activity
I6L37_06045	COG3072	Adenylate cyclase
I6L37_06050	COG0400	carboxylic ester hydrolase activity
I6L37_06055	COG1965	Belongs to the frataxin family
I6L37_06065	COG0019	diaminopimelate decarboxylase activity
I6L37_06070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L37_06085	COG1011	Hydrolase
I6L37_06090	COG0668	transmembrane transport
I6L37_06100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L37_06105	COG3028	Belongs to the UPF0307 family
I6L37_06110	COG0312	modulator of DNA gyrase
I6L37_06115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L37_06120	COG5007	Belongs to the BolA IbaG family
I6L37_06130	COG2854	intermembrane phospholipid transfer
I6L37_06135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L37_06140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L37_06145	COG1127	ABC transporter
I6L37_06150	COG0517	IMP dehydrogenase activity
I6L37_06150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L37_06155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L37_06160	COG3117	lipopolysaccharide transmembrane transporter activity
I6L37_06165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L37_06170	COG1137	ATPase activity
I6L37_06175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L37_06185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_06190	COG1660	Displays ATPase and GTPase activities
I6L37_06195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_06200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L37_06205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L37_06215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L37_06220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L37_06225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L37_06230	COG0723	plastoquinol--plastocyanin reductase activity
I6L37_06235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L37_06240	COG2857	Cytochrome c1
I6L37_06245	COG0625	glutathione transferase activity
I6L37_06250	COG2969	positive regulation of protein catabolic process
I6L37_06255	COG2823	Periplasmic or secreted lipoprotein
I6L37_06260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L37_06265	COG0792	nuclease activity
I6L37_06270	COG3107	peptidoglycan biosynthetic process
I6L37_06275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L37_06300	COG1987	bacterial-type flagellum assembly
I6L37_06325	COG1677	Flagellar hook-basal body complex protein FliE
I6L37_06335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L37_06370	COG1815	bacterial-type flagellum-dependent cell motility
I6L37_06385	COG1749	Flagellar hook protein flgE
I6L37_06395	COG4786	Flagellar basal body rod
I6L37_06400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L37_06405	COG1706	bacterial-type flagellum-dependent cell motility
I6L37_06415	COG1256	bacterial-type flagellum assembly
I6L37_06415	COG4786	Flagellar basal body rod
I6L37_06435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L37_06440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L37_06465	COG1191	sigma factor activity
I6L37_06470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L37_06485	COG0741	lytic transglycosylase activity
I6L37_06485	COG1388	LysM domain
I6L37_06495	COG2001	Belongs to the MraZ family
I6L37_06500	COG0275	rRNA processing
I6L37_06505	COG3116	cell division
I6L37_06510	COG0768	penicillin binding
I6L37_06520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L37_06525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L37_06530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L37_06535	COG0772	Belongs to the SEDS family
I6L37_06540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L37_06545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L37_06550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L37_06555	COG0849	cell division
I6L37_06560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L37_06565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L37_06575	COG0653	protein targeting
I6L37_06585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L37_06590	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L37_06600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6L37_06605	COG1459	type II secretion system
I6L37_06610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L37_06635	COG2186	Transcriptional regulator
I6L37_06640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L37_06645	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L37_06650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L37_06660	COG0840	transmembrane signaling receptor activity
I6L37_06665	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L37_06670	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L37_06675	COG2200	EAL domain
I6L37_06680	COG2200	EAL domain
I6L37_06690	COG0646	methionine synthase
I6L37_06690	COG1410	methionine synthase
I6L37_06695	COG0189	ligase activity
I6L37_06700	COG0642	Histidine kinase
I6L37_06705	COG0745	RESPONSE REGULATOR receiver
I6L37_06725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L37_06730	COG0352	thiamine-phosphate diphosphorylase activity
I6L37_06735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L37_06745	COG2022	thiamine diphosphate biosynthetic process
I6L37_06750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L37_06780	COG0110	maltose O-acetyltransferase activity
I6L37_06785	COG3314	Sporulation integral membrane protein YlbJ
I6L37_06805	COG0165	Argininosuccinate lyase
I6L37_06810	COG0137	argininosuccinate synthase activity
I6L37_06820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L37_06825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L37_06835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L37_06840	COG0406	alpha-ribazole phosphatase activity
I6L37_06855	COG0583	DNA-binding transcription factor activity
I6L37_06860	COG1380	Effector of murein hydrolase LrgA
I6L37_06865	COG1346	cytolysis
I6L37_06875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L37_06880	COG1546	Belongs to the CinA family
I6L37_06885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L37_06895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L37_06900	COG0527	aspartate kinase activity
I6L37_06905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L37_06935	COG1686	Belongs to the peptidase S11 family
I6L37_06940	COG0586	Pfam SNARE associated Golgi protein
I6L37_06945	COG1253	flavin adenine dinucleotide binding
I6L37_06950	COG0252	asparaginase activity
I6L37_06970	COG1263	PTS System
I6L37_06970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_06975	COG0366	Alpha amylase catalytic
I6L37_06980	COG0110	maltose O-acetyltransferase activity
I6L37_06990	COG0564	pseudouridine synthase activity
I6L37_06995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L37_07025	COG2926	Belongs to the UPF0265 family
I6L37_07040	COG0561	phosphatase activity
I6L37_07050	COG1058	Belongs to the CinA family
I6L37_07050	COG1546	Belongs to the CinA family
I6L37_07055	COG1418	mRNA catabolic process
I6L37_07060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L37_07070	COG1522	sequence-specific DNA binding
I6L37_07075	COG1368	sulfuric ester hydrolase activity
I6L37_07105	COG4221	oxidoreductase activity
I6L37_07120	COG1979	alcohol dehydrogenase
I6L37_07125	COG1803	Methylglyoxal synthase
I6L37_07145	COG1444	tRNA N-acetyltransferase activity
I6L37_07150	COG2949	membrane
I6L37_07155	COG3291	Pkd domain containing protein
I6L37_07170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L37_07175	COG0596	Alpha beta hydrolase
I6L37_07180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L37_07185	COG1169	isochorismate synthase
I6L37_07190	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L37_07215	COG0513	Belongs to the DEAD box helicase family
I6L37_07220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L37_07225	COG1988	membrane-bound metal-dependent
I6L37_07240	COG1671	Belongs to the UPF0178 family
I6L37_07260	COG0484	heat shock protein binding
I6L37_07270	COG3722	fumarate hydratase activity
I6L37_07275	COG0246	Mannitol dehydrogenase
I6L37_07280	COG2213	PTS system mannitol-specific
I6L37_07280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_07285	COG1560	Kdo2-lipid A biosynthetic process
I6L37_07290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L37_07290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L37_07295	COG1538	Outer membrane efflux protein
I6L37_07300	COG0494	nUDIX hydrolase
I6L37_07305	COG3151	Protein conserved in bacteria
I6L37_07315	COG3150	esterase
I6L37_07320	COG1051	belongs to the nudix hydrolase family
I6L37_07330	COG0187	DNA topoisomerase II activity
I6L37_07335	COG2329	Antibiotic biosynthesis monooxygenase
I6L37_07350	COG4221	oxidoreductase activity
I6L37_07385	COG0814	amino acid
I6L37_07415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L37_07435	COG0204	Acyl-transferase
I6L37_07440	COG1842	Phage shock protein A
I6L37_07455	COG2827	Endonuclease containing a URI domain
I6L37_07470	COG1573	uracil-dna glycosylase
I6L37_07475	COG0697	spore germination
I6L37_07480	COG0583	DNA-binding transcription factor activity
I6L37_07485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L37_07490	COG1121	(ABC) transporter
I6L37_07495	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L37_07515	COG0739	heme binding
I6L37_07525	COG3068	Protein conserved in bacteria
I6L37_07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L37_07540	COG0583	DNA-binding transcription factor activity
I6L37_07545	COG0640	Transcriptional regulator
I6L37_07550	COG0268	Binds directly to 16S ribosomal RNA
I6L37_07555	COG0728	peptidoglycan biosynthetic process
I6L37_07560	COG0196	riboflavin kinase activity
I6L37_07565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L37_07570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L37_07575	COG1047	Peptidyl-prolyl cis-trans
I6L37_07580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L37_07640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L37_07640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L37_07655	COG1854	S-ribosylhomocysteine lyase activity
I6L37_07665	COG2165	general secretion pathway protein
I6L37_07670	COG0084	hydrolase, TatD family'
I6L37_07675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L37_07695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L37_07700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L37_07705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L37_07710	COG0813	purine-nucleoside phosphorylase activity
I6L37_07715	COG5001	Diguanylate cyclase
I6L37_07715	COG5002	protein histidine kinase activity
I6L37_07715	COG3447	MASE1 domain protein
I6L37_07725	COG0560	Phosphoserine phosphatase
I6L37_07755	COG0776	regulation of translation
I6L37_07765	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L37_07770	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L37_07775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L37_07780	COG0359	binds to the 23S rRNA
I6L37_07785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L37_07815	COG1064	alcohol dehydrogenase
I6L37_07820	COG1238	metal cluster binding
I6L37_07825	COG0612	Peptidase, M16
I6L37_07830	COG2918	glutathione biosynthetic process
I6L37_07840	COG1022	Amp-dependent synthetase and ligase
I6L37_07850	COG0456	acetyltransferase
I6L37_07865	COG0714	Associated with various cellular activities
I6L37_07870	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L37_07875	COG5001	Diguanylate cyclase
I6L37_07875	COG3300	MHYT domain
I6L37_07900	COG0456	acetyltransferase
I6L37_07905	COG0477	Major facilitator Superfamily
I6L37_07910	COG0583	DNA-binding transcription factor activity
I6L37_07915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L37_07920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L37_07930	COG0673	inositol 2-dehydrogenase activity
I6L37_07940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L37_07945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L37_07950	COG3036	rescue of stalled ribosome
I6L37_07960	COG0138	bifunctional purine biosynthesis protein purh
I6L37_07975	COG0494	nUDIX hydrolase
I6L37_07995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L37_08000	COG1640	4-alpha-glucanotransferase
I6L37_08005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L37_08015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L37_08020	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L37_08025	COG0330	HflC and HflK could
I6L37_08030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L37_08030	COG1648	precorrin-2 dehydrogenase activity
I6L37_08035	COG0175	sulfate reduction
I6L37_08040	COG2895	sulfate adenylyltransferase (ATP) activity
I6L37_08045	COG0471	metal ion transport
I6L37_08045	COG3273	potassium ion transport
I6L37_08050	COG0529	Catalyzes the synthesis of activated sulfate
I6L37_08055	COG2801	Transposase and inactivated derivatives
I6L37_08120	COG1136	(ABC) transporter
I6L37_08135	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L37_08150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L37_08155	COG0346	lactoylglutathione lyase activity
I6L37_08160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L37_08165	COG1643	Atp-dependent helicase
I6L37_08170	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6L37_08175	COG1489	DNA binding
I6L37_08180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L37_08185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L37_08200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L37_08205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L37_08220	COG0842	Transport permease protein
I6L37_08225	COG1131	(ABC) transporter
I6L37_08240	COG0163	prenyltransferase activity
I6L37_08245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L37_08250	COG0671	phosphoesterase, PA-phosphatase related
I6L37_08255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L37_08260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L37_08265	COG1151	hydroxylamine reductase activity
I6L37_08270	COG0783	Belongs to the Dps family
I6L37_08275	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L37_08280	COG4807	Protein conserved in bacteria
I6L37_08290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L37_08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L37_08300	COG3956	TIGRFAM MazG family protein
I6L37_08305	COG0504	CTP synthase activity
I6L37_08310	COG0148	phosphopyruvate hydratase activity
I6L37_08370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L37_08380	COG0488	(ABC) transporter
I6L37_08385	COG0517	IMP dehydrogenase activity
I6L37_08385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L37_08395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L37_08410	COG1794	racemase activity, acting on amino acids and derivatives
I6L37_08415	COG2132	Multicopper oxidase
I6L37_08425	COG2731	YhcH YjgK YiaL family protein
I6L37_08435	COG0668	transmembrane transport
I6L37_08440	COG1376	ErfK ybiS ycfS ynhG family protein
I6L37_08445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L37_08450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L37_08455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L37_08465	COG0585	pseudouridine synthase activity
I6L37_08470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L37_08475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L37_08480	COG1238	metal cluster binding
I6L37_08485	COG1388	LysM domain
I6L37_08485	COG4942	peptidase
I6L37_08495	COG1902	pentaerythritol trinitrate reductase activity
I6L37_08510	COG2957	Belongs to the agmatine deiminase family
I6L37_08515	COG0154	amidase activity
I6L37_08525	COG0513	Belongs to the DEAD box helicase family
I6L37_08530	COG2199	diguanylate cyclase activity
I6L37_08530	COG2203	Gaf domain
I6L37_08540	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L37_08565	COG2070	2-Nitropropane dioxygenase
I6L37_08595	COG2982	Protein involved in outer membrane biogenesis
I6L37_08605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L37_08615	COG2252	PERMEase
I6L37_08625	COG0488	(ABC) transporter
I6L37_08630	COG0741	lytic transglycosylase activity
I6L37_08635	COG0463	Glycosyl transferase, family 2
I6L37_08645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L37_08665	COG4608	Belongs to the ABC transporter superfamily
I6L37_08670	COG0444	Belongs to the ABC transporter superfamily
I6L37_08680	COG4239	(ABC) transporter, permease
I6L37_08695	COG0616	signal peptide processing
I6L37_08700	COG1902	pentaerythritol trinitrate reductase activity
I6L37_08700	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L37_08705	COG0778	Nitroreductase
I6L37_08710	COG2264	protein methyltransferase activity
I6L37_08715	COG0604	alcohol dehydrogenase
I6L37_08720	COG0583	DNA-binding transcription factor activity
I6L37_08725	COG1263	PTS System
I6L37_08725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_08725	COG2190	(PTS) system
I6L37_08730	COG4145	pantothenate transmembrane transporter activity
I6L37_08740	COG0439	Biotin carboxylase
I6L37_08745	COG0511	ligase activity, forming carbon-carbon bonds
I6L37_08750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L37_08755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L37_08760	COG5001	Diguanylate cyclase
I6L37_08760	COG3300	MHYT domain
I6L37_08775	COG3381	protein complex oligomerization
I6L37_08785	COG3005	denitrification pathway
I6L37_08790	COG0745	RESPONSE REGULATOR receiver
I6L37_08800	COG1879	ABC-type sugar transport system periplasmic component
I6L37_08805	COG2205	protein histidine kinase activity
I6L37_08805	COG2198	Histidine kinase
I6L37_08805	COG0784	Response regulator, receiver
I6L37_08810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L37_08815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L37_08820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L37_08820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L37_08840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L37_08845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L37_08850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L37_08855	COG4172	Belongs to the ABC transporter superfamily
I6L37_08865	COG0601	transmembrane transport
I6L37_08875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L37_08880	COG0142	geranyltranstransferase activity
I6L37_08885	COG1722	exodeoxyribonuclease VII activity
I6L37_08890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L37_08895	COG1360	Flagellar Motor Protein
I6L37_08895	COG1360	Flagellar Motor Protein
I6L37_08910	COG1534	Rna-binding protein
I6L37_08915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L37_08925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L37_08930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L37_08935	COG0149	triose-phosphate isomerase activity
I6L37_08940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L37_08955	COG0779	Required for maturation of 30S ribosomal subunits
I6L37_08960	COG0195	Participates in both transcription termination and antitermination
I6L37_08965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L37_08970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L37_08975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L37_08980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L37_08985	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L37_08990	COG2201	protein-glutamate methylesterase activity
I6L37_08995	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6L37_09000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L37_09005	COG0840	transmembrane signaling receptor activity
I6L37_09010	COG0835	chemotaxis
I6L37_09015	COG0643	Histidine kinase
I6L37_09015	COG2198	Histidine kinase
I6L37_09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L37_09040	COG0583	DNA-binding transcription factor activity
I6L37_09045	COG1280	lysine exporter protein (LysE YggA)
I6L37_09050	COG0826	peptidase U32
I6L37_09060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L37_09100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L37_09125	COG0300	oxidoreductase activity
I6L37_09150	COG0583	DNA-binding transcription factor activity
I6L37_09165	COG0549	Belongs to the carbamate kinase family
I6L37_09170	COG1304	FMN binding
I6L37_09175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L37_09180	COG1335	isochorismatase
I6L37_09220	COG5433	transposase activity
I6L37_09260	COG2771	luxR family
I6L37_09285	COG1484	DNA-dependent DNA replication
I6L37_09290	COG4584	PFAM Integrase catalytic
I6L37_09300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L37_09325	COG0732	type I restriction modification DNA specificity domain
I6L37_09340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6L37_09350	COG1715	Restriction endonuclease
I6L37_09405	COG2003	Belongs to the UPF0758 family
I6L37_09445	COG5377	YqaJ viral recombinase family
I6L37_09475	COG0077	Prephenate dehydratase
I6L37_09475	COG1605	Chorismate mutase
I6L37_09505	COG3272	Protein of unknown function (DUF1722)
I6L37_09510	COG0789	Transcriptional regulator
I6L37_09515	COG0415	Belongs to the DNA photolyase family
I6L37_09525	COG0300	oxidoreductase activity
I6L37_09540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L37_09570	COG1477	protein flavinylation
I6L37_09575	COG2871	sodium ion transport
I6L37_09580	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L37_09585	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L37_09590	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L37_09595	COG1805	sodium ion transport
I6L37_09600	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L37_09605	COG0271	Belongs to the BolA IbaG family
I6L37_09610	COG2813	Specifically methylates the guanine in position
I6L37_09620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L37_09625	COG2211	Major facilitator Superfamily
I6L37_09630	COG3248	Nucleoside-binding outer membrane protein
I6L37_09635	COG1666	GTP binding
I6L37_09640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L37_09655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L37_09660	COG0840	transmembrane signaling receptor activity
I6L37_09665	COG0583	DNA-binding transcription factor activity
I6L37_09675	COG2363	Small membrane protein
I6L37_09680	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L37_09690	COG0473	3-isopropylmalate dehydrogenase activity
I6L37_09695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L37_09700	COG1611	Belongs to the LOG family
I6L37_09715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L37_09715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L37_09725	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L37_09750	COG3098	single-species biofilm formation
I6L37_09755	COG0564	pseudouridine synthase activity
I6L37_09760	COG0716	FMN binding
I6L37_09775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_09775	COG1263	PTS System
I6L37_09785	COG2171	N-acyltransferase activity
I6L37_09790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L37_09795	COG0024	Methionine aminopeptidase
I6L37_09800	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L37_09805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L37_09810	COG0528	UMP kinase activity
I6L37_09815	COG0233	cytoplasmic translational termination
I6L37_09820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L37_09825	COG0575	Belongs to the CDS family
I6L37_09830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L37_09835	COG0750	zinc metalloprotease
I6L37_09840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L37_09850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L37_09855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L37_09860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L37_09865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L37_09870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L37_09880	COG0825	malonyl-CoA metabolic process
I6L37_09890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L37_09895	COG1115	amino acid carrier protein
I6L37_09910	COG0714	Associated with various cellular activities
I6L37_09920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L37_09925	COG1678	Uncharacterized ACR, COG1678
I6L37_09935	COG0189	ligase activity
I6L37_09940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L37_09950	COG3091	SprT-like family
I6L37_09960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L37_09980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L37_09985	COG0739	heme binding
I6L37_09990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L37_10005	COG0814	amino acid
I6L37_10010	COG0531	amino acid
I6L37_10015	COG3710	Transcriptional regulator
I6L37_10020	COG0531	amino acid
I6L37_10025	COG1982	Orn Lys Arg decarboxylase major
I6L37_10030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L37_10040	COG3590	peptidase
I6L37_10050	COG2199	diguanylate cyclase activity
I6L37_10050	COG2203	Gaf domain
I6L37_10085	COG0366	Alpha amylase catalytic
I6L37_10100	COG0463	Glycosyl transferase, family 2
I6L37_10115	COG2989	Protein conserved in bacteria
I6L37_10120	COG3108	Peptidase M15
I6L37_10130	COG2860	membrane
I6L37_10140	COG1196	nuclear chromosome segregation
I6L37_10145	COG3115	cell septum assembly
I6L37_10150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L37_10160	COG1328	CTP reductase activity
I6L37_10165	COG0602	queuosine metabolic process
I6L37_10190	COG1566	PFAM secretion protein HlyD family protein
I6L37_10205	COG3290	protein histidine kinase activity
I6L37_10215	COG0697	spore germination
I6L37_10230	COG3284	Transcriptional regulator
I6L37_10235	COG3706	GGDEF domain
I6L37_10240	COG0346	lactoylglutathione lyase activity
I6L37_10245	COG0745	RESPONSE REGULATOR receiver
I6L37_10250	COG5002	protein histidine kinase activity
I6L37_10275	COG3142	Participates in the control of copper homeostasis
I6L37_10285	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L37_10300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L37_10310	COG0678	peroxiredoxin activity
I6L37_10320	COG0019	diaminopimelate decarboxylase activity
I6L37_10325	COG1115	amino acid carrier protein
I6L37_10330	COG0095	Lipoate-protein ligase
I6L37_10335	COG2233	PERMEase
I6L37_10340	COG3706	GGDEF domain
I6L37_10350	COG0534	Mate efflux family protein
I6L37_10360	COG0281	malic enzyme
I6L37_10390	COG0733	neurotransmitter:sodium symporter activity
I6L37_10395	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L37_10405	COG1566	PFAM secretion protein HlyD family protein
I6L37_10410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L37_10415	COG1032	radical SAM domain protein
I6L37_10430	COG0673	inositol 2-dehydrogenase activity
I6L37_10440	COG2920	part of a sulfur-relay system
I6L37_10445	COG1289	transmembrane transporter activity
I6L37_10450	COG0670	Belongs to the BI1 family
I6L37_10470	COG1486	melibiose metabolic process
I6L37_10475	COG2169	Transcriptional regulator
I6L37_10475	COG1917	Cupin 2, conserved barrel domain protein
I6L37_10480	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L37_10485	COG2723	6-phospho-beta-galactosidase activity
I6L37_10490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L37_10495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L37_10510	COG2731	YhcH YjgK YiaL family protein
I6L37_10515	COG0800	Aldolase
I6L37_10520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L37_10525	COG1414	Transcriptional regulator
I6L37_10535	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_10550	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L37_10560	COG3156	type II secretion system protein K
I6L37_10565	COG4795	General secretion pathway protein
I6L37_10570	COG2165	general secretion pathway protein
I6L37_10580	COG2165	general secretion pathway protein
I6L37_10585	COG1459	type II secretion system
I6L37_10590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L37_10600	COG3031	protein transport across the cell outer membrane
I6L37_10610	COG3267	Type II secretory pathway component ExeA
I6L37_10610	COG3409	Peptidoglycan-binding domain 1 protein
I6L37_10615	COG3437	response regulator, receiver
I6L37_10615	COG2770	Histidine kinase
I6L37_10630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L37_10635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L37_10640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_10645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L37_10650	COG2190	(PTS) system
I6L37_10655	COG1196	nuclear chromosome segregation
I6L37_10655	COG3264	Mechanosensitive ion channel
I6L37_10660	COG0469	pyruvate kinase activity
I6L37_10670	COG3384	dioxygenase
I6L37_10675	COG0419	ATPase involved in DNA repair
I6L37_10680	COG0420	3'-5' exonuclease activity
I6L37_10690	COG2974	May be involved in recombination
I6L37_10700	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L37_10705	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L37_10720	COG0531	amino acid
I6L37_10725	COG0531	amino acid
I6L37_10735	COG1012	belongs to the aldehyde dehydrogenase family
I6L37_10740	COG1396	sequence-specific DNA binding
I6L37_10740	COG1917	Cupin 2, conserved barrel domain protein
I6L37_10745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_10800	COG2862	Uncharacterized protein family, UPF0114
I6L37_10820	COG3038	cytochrome b561
I6L37_10825	COG1720	tRNA m6t6A37 methyltransferase activity
I6L37_10845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L37_10850	COG4988	ABC transporter
I6L37_10865	COG0745	RESPONSE REGULATOR receiver
I6L37_10875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L37_10890	COG0640	Transcriptional regulator
I6L37_10905	COG0798	PFAM Bile acid sodium symporter
I6L37_10915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L37_10920	COG1070	Carbohydrate kinase
I6L37_10925	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L37_10930	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L37_10935	COG1129	ABC transporter
I6L37_10965	COG1988	membrane-bound metal-dependent
I6L37_10985	COG0159	tryptophan synthase activity
I6L37_10990	COG0133	tryptophan synthase activity
I6L37_10995	COG0135	phosphoribosylanthranilate isomerase activity
I6L37_10995	COG0134	indole-3-glycerol-phosphate synthase activity
I6L37_11000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L37_11005	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L37_11005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L37_11010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L37_11020	COG0009	L-threonylcarbamoyladenylate synthase
I6L37_11030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L37_11055	COG3210	domain, Protein
I6L37_11075	COG1946	Acyl-CoA thioesterase
I6L37_11080	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L37_11085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L37_11095	COG0083	homoserine kinase activity
I6L37_11100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L37_11115	COG1943	Transposase
I6L37_11125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L37_11130	COG2130	NADP-dependent
I6L37_11135	COG1309	transcriptional regulator
I6L37_11140	COG1609	Transcriptional regulator
I6L37_11145	COG1263	PTS System
I6L37_11145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_11150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L37_11155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L37_11160	COG1960	acyl-CoA dehydrogenase activity
I6L37_11170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L37_11185	COG0741	lytic transglycosylase activity
I6L37_11185	COG0739	heme binding
I6L37_11185	COG1196	nuclear chromosome segregation
I6L37_11265	COG1940	carbohydrate kinase activity
I6L37_11270	COG0457	Tetratricopeptide repeat
I6L37_11275	COG0477	Major facilitator Superfamily
I6L37_11275	COG2814	Major facilitator Superfamily
I6L37_11280	COG2017	converts alpha-aldose to the beta-anomer
I6L37_11285	COG1349	DNA-binding transcription factor activity
I6L37_11295	COG2222	sugar isomerase
I6L37_11300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_11305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L37_11315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_11320	COG3715	PTS system
I6L37_11325	COG3716	PTS system mannose fructose sorbose family IID component
I6L37_11330	COG4821	SIS domain
I6L37_11335	COG4821	SIS domain
I6L37_11345	COG3383	formate dehydrogenase (NAD+) activity
I6L37_11350	COG1454	alcohol dehydrogenase
I6L37_11360	COG0235	Class ii aldolase
I6L37_11375	COG0738	Major facilitator superfamily
I6L37_11380	COG1349	DNA-binding transcription factor activity
I6L37_11425	COG0582	viral genome integration into host DNA
I6L37_11430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L37_11460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L37_11465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6L37_11505	COG2003	Belongs to the UPF0758 family
I6L37_11540	COG5377	YqaJ viral recombinase family
I6L37_11560	COG4983	Phage plasmid primase, P4 family domain protein
I6L37_11575	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L37_11580	COG0582	viral genome integration into host DNA
I6L37_11590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L37_11595	COG2867	negative regulation of translational initiation
I6L37_11600	COG2914	Belongs to the UPF0125 (RnfH) family
I6L37_11605	COG1473	amidohydrolase
I6L37_11610	COG1960	acyl-CoA dehydrogenase activity
I6L37_11615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L37_11620	COG0121	glutamine amidotransferase
I6L37_11650	COG2197	response regulator
I6L37_11655	COG3850	Histidine kinase
I6L37_11660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L37_11665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L37_11675	COG0243	molybdopterin cofactor binding
I6L37_11680	COG0437	4 iron, 4 sulfur cluster binding
I6L37_11685	COG0348	domain, Protein
I6L37_11695	COG3005	denitrification pathway
I6L37_11700	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L37_11705	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L37_11710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L37_11715	COG0314	molybdopterin synthase activity
I6L37_11730	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L37_11735	COG2267	carboxylic ester hydrolase activity
I6L37_11760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L37_11770	COG0302	gtp cyclohydrolase
I6L37_11775	COG0840	transmembrane signaling receptor activity
I6L37_11780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L37_11790	COG0583	DNA-binding transcription factor activity
I6L37_11795	COG2353	YceI-like domain
I6L37_11805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L37_11820	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L37_11825	COG1166	arginine decarboxylase activity
I6L37_11835	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L37_11840	COG0583	DNA-binding transcription factor activity
I6L37_11855	COG0814	amino acid
I6L37_11860	COG0251	oxidation-reduction process
I6L37_11865	COG3681	Belongs to the UPF0597 family
I6L37_11875	COG0745	RESPONSE REGULATOR receiver
I6L37_11880	COG2205	protein histidine kinase activity
I6L37_11890	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L37_11895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L37_11895	COG3264	Mechanosensitive ion channel
I6L37_11900	COG0436	Aminotransferase
I6L37_11915	COG0739	heme binding
I6L37_11915	COG0741	lytic transglycosylase activity
I6L37_11915	COG1196	nuclear chromosome segregation
I6L37_11930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L37_11940	COG0788	formyltetrahydrofolate deformylase activity
I6L37_11945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L37_11965	COG0791	NLP P60 protein
I6L37_11970	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L37_11980	COG0471	metal ion transport
I6L37_11990	COG1376	ErfK ybiS ycfS ynhG family protein
I6L37_11990	COG1388	LysM domain
I6L37_12010	COG3706	GGDEF domain
I6L37_12070	COG2003	Belongs to the UPF0758 family
I6L37_12115	COG5377	YqaJ viral recombinase family
I6L37_12135	COG4983	Phage plasmid primase, P4 family domain protein
I6L37_12150	COG1349	DNA-binding transcription factor activity
I6L37_12155	COG0738	Major facilitator superfamily
I6L37_12170	COG0235	Class ii aldolase
I6L37_12185	COG0469	pyruvate kinase activity
I6L37_12190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L37_12195	COG1085	galactose-1-phosphate uridylyltransferase
I6L37_12200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L37_12205	COG1609	Transcriptional regulator
I6L37_12230	COG3710	Transcriptional regulator
I6L37_12240	COG5001	Diguanylate cyclase
I6L37_12240	COG3300	MHYT domain
I6L37_12270	COG3710	Transcriptional regulator
I6L37_12290	COG0702	epimerase
I6L37_12295	COG0823	Involved in the tonB-independent uptake of proteins
I6L37_12295	COG1506	peptidase
I6L37_12300	COG1073	alpha beta
I6L37_12315	COG3501	Rhs element vgr protein
I6L37_12325	COG3209	COG3209 Rhs family protein
I6L37_12345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L37_12355	COG0729	surface antigen
I6L37_12360	COG2911	Protein conserved in bacteria
I6L37_12380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L37_12400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L37_12405	COG4771	TonB-dependent receptor
I6L37_12410	COG1169	isochorismate synthase
I6L37_12415	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L37_12420	COG1535	isochorismatase
I6L37_12420	COG3433	isochorismatase activity
I6L37_12425	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_12430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L37_12430	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L37_12455	COG1278	Cold shock
I6L37_12480	COG4166	transmembrane transport
I6L37_12490	COG1349	DNA-binding transcription factor activity
I6L37_12495	COG1882	Formate acetyltransferase
I6L37_12500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L37_12505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L37_12515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L37_12530	COG4166	transmembrane transport
I6L37_12535	COG0622	Phosphoesterase
I6L37_12550	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L37_12555	COG0835	chemotaxis
I6L37_12555	COG0784	Response regulator, receiver
I6L37_12560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L37_12565	COG1815	bacterial-type flagellum-dependent cell motility
I6L37_12580	COG1749	Flagellar hook protein flgE
I6L37_12585	COG4787	bacterial-type flagellum-dependent cell motility
I6L37_12595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L37_12600	COG1706	bacterial-type flagellum-dependent cell motility
I6L37_12605	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L37_12605	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L37_12620	COG2239	Acts as a magnesium transporter
I6L37_12630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L37_12635	COG2716	regulation of RNA biosynthetic process
I6L37_12660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L37_12665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L37_12670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L37_12675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L37_12695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L37_12710	COG0590	tRNA wobble adenosine to inosine editing
I6L37_12715	COG0573	inorganic phosphate transmembrane transporter activity
I6L37_12720	COG0581	inorganic phosphate transmembrane transporter activity
I6L37_12725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L37_12730	COG0704	Plays a role in the regulation of phosphate uptake
I6L37_12735	COG1253	flavin adenine dinucleotide binding
I6L37_12755	COG1126	abc transporter atp-binding protein
I6L37_12760	COG0765	amino acid transport
I6L37_12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L37_12770	COG2271	Major facilitator Superfamily
I6L37_12780	COG2197	response regulator
I6L37_12785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L37_12810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L37_12815	COG0477	Major facilitator Superfamily
I6L37_12820	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L37_12830	COG1199	ATP-dependent helicase activity
I6L37_12840	COG0287	Prephenate dehydrogenase
I6L37_12840	COG1605	Chorismate mutase
I6L37_12845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L37_12855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L37_12865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L37_12900	COG0537	adenosine 5'-monophosphoramidase activity
I6L37_12920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L37_12935	COG1301	dicarboxylic acid transport
I6L37_12940	COG1733	regulation of RNA biosynthetic process
I6L37_12955	COG2354	Protein conserved in bacteria
I6L37_12965	COG2233	PERMEase
I6L37_12975	COG1252	NADH dehydrogenase
I6L37_12995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L37_13000	COG3300	MHYT domain
I6L37_13000	COG5001	Diguanylate cyclase
I6L37_13005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L37_13015	COG2373	Large extracellular alpha-helical protein
I6L37_13020	COG4953	penicillin-binding protein 1C
I6L37_13030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L37_13030	COG0301	tRNA thio-modification
I6L37_13045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L37_13065	COG1334	flagellar protein FlaG
I6L37_13100	COG2089	acid synthase
I6L37_13110	COG1083	cytidylyl-transferase
I6L37_13130	COG0318	PFAM AMP-dependent synthetase and ligase
I6L37_13145	COG1216	Glycosyl transferase, family 2
I6L37_13185	COG0859	PFAM glycosyl transferase family 9
I6L37_13200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L37_13205	COG1086	Polysaccharide biosynthesis protein
I6L37_13210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L37_13220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L37_13245	COG0625	glutathione transferase activity
I6L37_13250	COG2814	Major facilitator Superfamily
I6L37_13255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L37_13265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L37_13270	COG0215	cysteine-tRNA ligase activity
I6L37_13275	COG0556	nucleotide-excision repair
I6L37_13330	COG2119	membrane
I6L37_13335	COG0023	Translation Initiation Factor
I6L37_13345	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L37_13360	COG0513	Belongs to the DEAD box helicase family
I6L37_13365	COG0493	'glutamate synthase
I6L37_13370	COG0069	glutamate synthase activity
I6L37_13370	COG0067	glutamate synthase
I6L37_13370	COG0070	glutamate synthase
I6L37_13375	COG1242	4 iron, 4 sulfur cluster binding
I6L37_13430	COG3634	alkyl hydroperoxide reductase activity
I6L37_13440	COG0517	IMP dehydrogenase activity
I6L37_13445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L37_13450	COG0343	queuine tRNA-ribosyltransferase activity
I6L37_13455	COG1862	Preprotein translocase
I6L37_13460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L37_13465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L37_13480	COG0826	peptidase U32
I6L37_13485	COG0826	peptidase U32
I6L37_13490	COG3154	lipid carrier protein
I6L37_13505	COG1959	2 iron, 2 sulfur cluster binding
I6L37_13510	COG1104	cysteine desulfurase activity
I6L37_13515	COG0822	iron-sulfur transferase activity
I6L37_13525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L37_13530	COG0443	Heat shock 70 kDa protein
I6L37_13535	COG0633	Ferredoxin
I6L37_13545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L37_13550	COG0105	UTP biosynthetic process
I6L37_13555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L37_13565	COG1426	Protein conserved in bacteria
I6L37_13570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6L37_13575	COG0124	histidyl-tRNA synthetase
I6L37_13580	COG2976	Protein conserved in bacteria
I6L37_13585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L37_13590	COG1160	GTP binding
I6L37_13595	COG1645	bacterial-type flagellum-dependent swarming motility
I6L37_13605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L37_13610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L37_13610	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L37_13615	COG2056	Na+-H+ antiporter family
I6L37_13620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L37_13625	COG0671	phosphoesterase, PA-phosphatase related
I6L37_13630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L37_13635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L37_13645	COG0101	tRNA pseudouridine synthase activity
I6L37_13650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L37_13655	COG0285	dihydrofolate synthase activity
I6L37_13660	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L37_13665	COG0393	Putative heavy-metal-binding
I6L37_13670	COG1368	sulfuric ester hydrolase activity
I6L37_13680	COG0527	aspartate kinase activity
I6L37_13685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L37_13685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L37_13690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L37_13710	COG0596	Alpha beta hydrolase
I6L37_13715	COG0346	lactoylglutathione lyase activity
I6L37_13725	COG0583	DNA-binding transcription factor activity
I6L37_13730	COG1620	l-lactate permease
I6L37_13735	COG0247	lactate metabolic process
I6L37_13740	COG1139	Iron-sulfur cluster binding protein
I6L37_13760	COG5433	transposase activity
I6L37_13775	COG0577	efflux transmembrane transporter activity
I6L37_13800	COG2814	Major facilitator Superfamily
I6L37_13825	COG0672	)-iron permease
I6L37_13850	COG0659	secondary active sulfate transmembrane transporter activity
I6L37_13860	COG2814	Major facilitator Superfamily
I6L37_13865	COG0583	DNA-binding transcription factor activity
I6L37_13870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L37_13875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L37_13880	COG0539	negative regulation of cytoplasmic translation
I6L37_13885	COG0776	regulation of translation
I6L37_13895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L37_13915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L37_13920	COG0602	queuosine metabolic process
I6L37_13925	COG3530	Putative quorum-sensing-regulated virulence factor
I6L37_13930	COG2096	Adenosyltransferase
I6L37_13935	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L37_13940	COG1757	Na H antiporter
I6L37_13945	COG1435	thymidine kinase activity
I6L37_13965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L37_13970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L37_13975	COG0326	Molecular chaperone. Has ATPase activity
I6L37_13980	COG4172	Belongs to the ABC transporter superfamily
I6L37_13990	COG4171	peptide transport system, permease
I6L37_13995	COG4168	peptide transport system, permease
I6L37_14000	COG0747	negative chemotaxis
I6L37_14005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L37_14010	COG1842	Phage shock protein A
I6L37_14025	COG3106	COG3106 Predicted ATPase
I6L37_14030	COG3768	UPF0283 membrane protein
I6L37_14035	COG0583	DNA-binding transcription factor activity
I6L37_14040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L37_14045	COG3842	ATPase activity
I6L37_14050	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L37_14055	COG1177	transmembrane transport
I6L37_14060	COG1012	belongs to the aldehyde dehydrogenase family
I6L37_14070	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L37_14090	COG2199	diguanylate cyclase activity
I6L37_14095	COG2885	chlorophyll binding
I6L37_14095	COG3047	cAMP biosynthetic process
I6L37_14100	COG0861	Integral membrane protein TerC family
I6L37_14115	COG1022	Amp-dependent synthetase and ligase
I6L37_14140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L37_14145	COG1278	Cold shock
I6L37_14150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L37_14155	COG0542	response to heat
I6L37_14160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L37_14165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L37_14170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L37_14175	COG3134	Outer membrane lipoprotein
I6L37_14180	COG3706	GGDEF domain
I6L37_14185	COG0492	ferredoxin-NADP+ reductase activity
I6L37_14190	COG0686	Belongs to the AlaDH PNT family
I6L37_14200	COG0531	amino acid
I6L37_14200	COG1674	ftsk spoiiie
I6L37_14205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L37_14210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L37_14215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L37_14220	COG1286	toxin biosynthetic process
I6L37_14225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L37_14235	COG0563	adenylate kinase activity
I6L37_14240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L37_14250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L37_14255	COG0840	transmembrane signaling receptor activity
I6L37_14270	COG3300	MHYT domain
I6L37_14270	COG5001	Diguanylate cyclase
I6L37_14325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L37_14330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L37_14335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L37_14350	COG0513	Belongs to the DEAD box helicase family
I6L37_14355	COG0386	Belongs to the glutathione peroxidase family
I6L37_14365	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L37_14370	COG1570	exodeoxyribonuclease VII activity
I6L37_14375	COG2200	EAL domain
I6L37_14385	COG0517	IMP dehydrogenase activity
I6L37_14385	COG0516	GMP reductase activity
I6L37_14390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L37_14390	COG0519	Catalyzes the synthesis of GMP from XMP
I6L37_14410	COG0500	methyltransferase
I6L37_14420	COG2062	phosphohistidine phosphatase, SixA
I6L37_14430	COG0697	spore germination
I6L37_14435	COG4166	transmembrane transport
I6L37_14440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L37_14445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L37_14455	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L37_14460	COG1136	(ABC) transporter
I6L37_14465	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L37_14470	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L37_14480	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L37_14485	COG0740	serine-type endopeptidase activity
I6L37_14490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L37_14495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L37_14500	COG0776	regulation of translation
I6L37_14505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L37_14510	COG0488	(ABC) transporter
I6L37_14535	COG3104	oligopeptide transport
I6L37_14545	COG3104	oligopeptide transport
I6L37_14560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L37_14565	COG3162	membrane
I6L37_14580	COG1024	Enoyl-CoA hydratase
I6L37_14585	COG1115	amino acid carrier protein
I6L37_14595	COG3228	Belongs to the MtfA family
I6L37_14600	COG1584	GPR1 FUN34 yaaH family protein
I6L37_14630	COG1024	Enoyl-CoA hydratase
I6L37_14635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L37_14640	COG1960	acyl-CoA dehydrogenase activity
I6L37_14645	COG1960	acyl-CoA dehydrogenase activity
I6L37_14650	COG1024	Enoyl-CoA hydratase
I6L37_14655	COG1024	Enoyl-CoA hydratase
I6L37_14665	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_14675	COG0730	response to heat
I6L37_14685	COG0582	viral genome integration into host DNA
I6L37_14715	COG2003	Belongs to the UPF0758 family
I6L37_14780	COG0789	Transcriptional regulator
I6L37_14795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L37_14830	COG0471	metal ion transport
I6L37_14840	COG2954	triphosphatase activity
I6L37_14845	COG0583	DNA-binding transcription factor activity
I6L37_14860	COG0582	viral genome integration into host DNA
I6L37_14865	COG1414	Transcriptional regulator
I6L37_14905	COG0437	4 iron, 4 sulfur cluster binding
I6L37_14910	COG5557	Pfam Polysulphide reductase, NrfD
I6L37_14915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L37_14920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L37_14925	COG1773	rubredoxin
I6L37_14930	COG0747	negative chemotaxis
I6L37_14940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L37_14950	COG3842	ATPase activity
I6L37_14955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L37_14960	COG0375	protein maturation
I6L37_14965	COG0309	Hydrogenase expression formation protein (HypE)
I6L37_14975	COG0298	carbon dioxide binding
I6L37_14980	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L37_14990	COG1921	L-seryl-tRNASec selenium transferase activity
I6L37_15000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L37_15010	COG3260	NADH ubiquinone oxidoreductase 20
I6L37_15015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_15020	COG3261	NADH dehydrogenase
I6L37_15020	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L37_15025	COG0650	Formate hydrogenlyase subunit 4
I6L37_15030	COG0651	ATP synthesis coupled electron transport
I6L37_15035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L37_15045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_15050	COG3715	PTS system
I6L37_15055	COG3716	PTS system mannose fructose sorbose family IID component
I6L37_15060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_15060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_15065	COG4821	SIS domain
I6L37_15070	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6L37_15075	COG4821	SIS domain
I6L37_15085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L37_15095	COG5433	transposase activity
I6L37_15120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L37_15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_15130	COG0295	cytidine deaminase activity
I6L37_15135	COG1346	cytolysis
I6L37_15140	COG1380	Effector of murein hydrolase LrgA
I6L37_15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_15160	COG0295	cytidine deaminase activity
I6L37_15165	COG1346	cytolysis
I6L37_15170	COG1380	Effector of murein hydrolase LrgA
I6L37_15175	COG3345	alpha-galactosidase
I6L37_15185	COG2925	Exonuclease
I6L37_15195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L37_15200	COG0436	Aminotransferase
I6L37_15205	COG0583	DNA-binding transcription factor activity
I6L37_15210	COG0517	IMP dehydrogenase activity
I6L37_15210	COG0617	tRNA 3'-terminal CCA addition
I6L37_15210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L37_15215	COG1643	Atp-dependent helicase
I6L37_15225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L37_15240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L37_15245	COG2067	long-chain fatty acid transport protein
I6L37_15250	COG2067	long-chain fatty acid transport protein
I6L37_15260	COG1595	DNA-templated transcription, initiation
I6L37_15270	COG2304	oxidoreductase activity
I6L37_15290	COG0714	Associated with various cellular activities
I6L37_15295	COG0183	Belongs to the thiolase family
I6L37_15300	COG1024	Enoyl-CoA hydratase
I6L37_15300	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L37_15305	COG2719	SpoVR family
I6L37_15310	COG2718	Belongs to the UPF0229 family
I6L37_15315	COG2766	serine protein kinase
I6L37_15320	COG0514	ATP-dependent DNA helicase (RecQ)
I6L37_15325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L37_15330	COG0814	amino acid
I6L37_15335	COG0494	nUDIX hydrolase
I6L37_15365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L37_15365	COG0140	phosphoribosyl-ATP diphosphatase activity
I6L37_15370	COG0107	imidazoleglycerol-phosphate synthase activity
I6L37_15375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L37_15380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L37_15385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L37_15385	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L37_15390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L37_15395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L37_15400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L37_15410	COG1199	ATP-dependent helicase activity
I6L37_15415	COG1214	PFAM Peptidase M22, glycoprotease
I6L37_15425	COG0596	Alpha beta hydrolase
I6L37_15430	COG0318	PFAM AMP-dependent synthetase and ligase
I6L37_15440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L37_15445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L37_15450	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L37_15465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L37_15475	COG1254	Belongs to the acylphosphatase family
I6L37_15480	COG0625	glutathione transferase activity
I6L37_15485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L37_15485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L37_15490	COG0489	protein tyrosine kinase activity
I6L37_15495	COG0572	uridine kinase
I6L37_15500	COG0717	Belongs to the dCTP deaminase family
I6L37_15505	COG0306	phosphate transporter
I6L37_15510	COG1530	ribonuclease E activity
I6L37_15520	COG0424	maF-like protein
I6L37_15525	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L37_15530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L37_15535	COG0416	fatty acid biosynthetic process
I6L37_15540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L37_15550	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_15555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L37_15565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L37_15570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L37_15575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L37_15580	COG0470	DNA polymerase III
I6L37_15585	COG0084	hydrolase, TatD family'
I6L37_15600	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L37_15600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L37_15605	COG3008	intermembrane lipid transfer
I6L37_15610	COG2995	paraquat-inducible protein a
I6L37_15620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L37_15625	COG0372	Belongs to the citrate synthase family
I6L37_15670	COG4221	oxidoreductase activity
I6L37_15680	COG3141	response to X-ray
I6L37_15780	COG1067	ATP-dependent peptidase activity
I6L37_15785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L37_15795	COG0488	(ABC) transporter
I6L37_15805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L37_15805	COG0116	Belongs to the methyltransferase superfamily
I6L37_15810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L37_15815	COG0254	rRNA binding
I6L37_15835	COG0840	transmembrane signaling receptor activity
I6L37_15835	COG3290	protein histidine kinase activity
I6L37_15845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L37_15850	COG2201	protein-glutamate methylesterase activity
I6L37_15855	COG2203	Gaf domain
I6L37_15855	COG3706	GGDEF domain
I6L37_15855	COG5001	Diguanylate cyclase
I6L37_15855	COG4251	negative regulation of phosphorylation
I6L37_15865	COG0167	dihydroorotate dehydrogenase activity
I6L37_15870	COG2902	Dehydrogenase
I6L37_15880	COG0308	aminopeptidase N
I6L37_15885	COG0793	Belongs to the peptidase S41A family
I6L37_15890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L37_15895	COG1956	GAF domain-containing protein
I6L37_15905	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L37_15920	COG2010	Cytochrome c
I6L37_15930	COG2217	Heavy metal translocating P-type atpase
I6L37_15945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L37_15950	COG0589	response to stress
I6L37_15955	COG0037	tRNA processing
I6L37_15980	COG1177	transmembrane transport
I6L37_15990	COG2194	sulfuric ester hydrolase activity
I6L37_15995	COG1869	D-ribose catabolic process
I6L37_16000	COG1129	ABC transporter
I6L37_16005	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L37_16010	COG1879	ABC-type sugar transport system periplasmic component
I6L37_16015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L37_16020	COG1609	Transcriptional regulator
I6L37_16025	COG3300	MHYT domain
I6L37_16025	COG5001	Diguanylate cyclase
I6L37_16050	COG2205	protein histidine kinase activity
I6L37_16050	COG0784	Response regulator, receiver
I6L37_16055	COG0776	regulation of translation
I6L37_16060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L37_16060	COG0072	phenylalanine-tRNA ligase activity
I6L37_16065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L37_16070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L37_16075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L37_16080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L37_16085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L37_16110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L37_16120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L37_16125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L37_16130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L37_16135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L37_16140	COG3313	Fe-S protein
I6L37_16145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L37_16145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L37_16145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L37_16150	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L37_16155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_16155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_16160	COG1609	Transcriptional regulator
I6L37_16165	COG0814	amino acid
I6L37_16170	COG0513	Belongs to the DEAD box helicase family
I6L37_16175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L37_16180	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L37_16185	COG2840	Smr protein MutS2
I6L37_16195	COG3706	GGDEF domain
I6L37_16210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6L37_16225	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L37_16230	COG3706	GGDEF domain
I6L37_16235	COG0318	PFAM AMP-dependent synthetase and ligase
I6L37_16240	COG1288	antiporter activity
I6L37_16250	COG3134	Outer membrane lipoprotein
I6L37_16255	COG2080	2 iron, 2 sulfur cluster binding
I6L37_16260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L37_16265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L37_16270	COG2252	PERMEase
I6L37_16275	COG0402	S-adenosylhomocysteine deaminase activity
I6L37_16285	COG2080	2 iron, 2 sulfur cluster binding
I6L37_16285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L37_16290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L37_16295	COG0402	S-adenosylhomocysteine deaminase activity
I6L37_16300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L37_16300	COG0493	'glutamate synthase
I6L37_16305	COG2068	MobA-Related Protein
I6L37_16310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L37_16315	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L37_16315	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L37_16320	COG0697	spore germination
I6L37_16325	COG0549	Belongs to the carbamate kinase family
I6L37_16335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L37_16340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L37_16345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L37_16355	COG0456	acetyltransferase
I6L37_16360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L37_16365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L37_16370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L37_16380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L37_16385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L37_16395	COG0205	6-phosphofructokinase activity
I6L37_16405	COG1301	dicarboxylic acid transport
I6L37_16410	COG3123	guanosine phosphorylase activity
I6L37_16415	COG1760	l-serine dehydratase
I6L37_16420	COG1760	l-serine dehydratase
I6L37_16425	COG3100	YcgL domain-containing protein
I6L37_16430	COG0850	regulation of cytokinetic process
I6L37_16435	COG2894	cell division
I6L37_16440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L37_16445	COG3099	Belongs to the UPF0263 family
I6L37_16450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L37_16490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L37_16495	COG0697	spore germination
I6L37_16500	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L37_16505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_16515	COG0307	riboflavin synthase, alpha
I6L37_16525	COG0534	Mate efflux family protein
I6L37_16555	COG3829	transcription factor binding
I6L37_16565	COG4681	YaeQ
I6L37_16575	COG2186	Transcriptional regulator
I6L37_16580	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L37_16590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L37_16595	COG0586	Pfam SNARE associated Golgi protein
I6L37_16605	COG0556	nucleotide-excision repair
I6L37_16620	COG2985	domain, Protein
I6L37_16620	COG0569	domain protein
I6L37_16625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L37_16630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_16630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L37_16645	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L37_16660	COG1451	nucleotide metabolic process
I6L37_16675	COG0417	DNA replication proofreading
I6L37_16690	COG1560	Kdo2-lipid A biosynthetic process
I6L37_16695	COG1560	Kdo2-lipid A biosynthetic process
I6L37_16710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L37_16715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L37_16725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L37_16730	COG2832	Protein of unknown function (DUF454)
I6L37_16735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L37_16745	COG1011	Hydrolase
I6L37_16750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L37_16800	COG3593	DNA synthesis involved in DNA repair
I6L37_16815	COG0583	DNA-binding transcription factor activity
I6L37_16820	COG0730	response to heat
I6L37_16825	COG3148	PFAM DTW domain containing protein
I6L37_16830	COG1846	Transcriptional regulator
I6L37_16830	COG1940	carbohydrate kinase activity
I6L37_16835	COG0840	transmembrane signaling receptor activity
I6L37_16840	COG3012	SEC-C Motif Domain Protein
I6L37_16845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L37_16850	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L37_16855	COG0247	lactate metabolic process
I6L37_16870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L37_16875	COG0437	4 iron, 4 sulfur cluster binding
I6L37_16880	COG3301	Polysulphide reductase, NrfD
I6L37_16885	COG1138	Cytochrome C-type biogenesis protein
I6L37_16895	COG3088	subunit of a heme lyase
I6L37_16895	COG4235	cytochrome complex assembly
I6L37_16900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_16905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L37_16910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L37_16920	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L37_16925	COG3842	ATPase activity
I6L37_16935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L37_16955	COG1446	asparaginase
I6L37_16975	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L37_16980	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L37_16985	COG0567	Dehydrogenase, E1 component
I6L37_16995	COG1053	succinate dehydrogenase
I6L37_17000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L37_17005	COG2009	succinate dehydrogenase
I6L37_17065	COG1175	transmembrane transport
I6L37_17070	COG0395	ABC-type sugar transport system, permease component
I6L37_17075	COG1554	hydrolase, family 65, central catalytic
I6L37_17080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_17090	COG5433	transposase activity
I6L37_17100	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L37_17115	COG2501	S4 domain
I6L37_17125	COG0583	DNA-binding transcription factor activity
I6L37_17135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L37_17145	COG1132	(ABC) transporter
I6L37_17150	COG1132	(ABC) transporter
I6L37_17160	COG3118	belongs to the thioredoxin family
I6L37_17165	COG0471	metal ion transport
I6L37_17170	COG0058	SHG alpha-glucan phosphorylase activity
I6L37_17185	COG2983	Belongs to the UPF0260 family
I6L37_17190	COG1882	Formate acetyltransferase
I6L37_17195	COG2116	formate transmembrane transporter activity
I6L37_17200	COG1944	ATP diphosphatase activity
I6L37_17205	COG2723	6-phospho-beta-galactosidase activity
I6L37_17210	COG0583	DNA-binding transcription factor activity
I6L37_17215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L37_17235	COG2207	Transcriptional regulator
I6L37_17235	COG3708	Transcriptional regulator
I6L37_17255	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L37_17260	COG5001	Diguanylate cyclase
I6L37_17260	COG3300	MHYT domain
I6L37_17265	COG0583	DNA-binding transcription factor activity
I6L37_17270	COG3437	response regulator, receiver
I6L37_17295	COG4989	oxidoreductase activity
I6L37_17300	COG0724	RNA recognition motif
I6L37_17310	COG1126	abc transporter atp-binding protein
I6L37_17315	COG0765	amino acid transport
I6L37_17325	COG0765	amino acid transport
I6L37_17330	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6L37_17340	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L37_17365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L37_17370	COG1360	Flagellar Motor Protein
I6L37_17375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_17380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_17385	COG0649	NAD binding
I6L37_17385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_17400	COG1034	ATP synthesis coupled electron transport
I6L37_17405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L37_17410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_17415	COG0839	Belongs to the complex I subunit 6 family
I6L37_17420	COG0713	ATP synthesis coupled electron transport
I6L37_17430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L37_17435	COG1007	ATP synthesis coupled electron transport
I6L37_17445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L37_17450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L37_17450	COG2199	diguanylate cyclase activity
I6L37_17460	COG2050	protein possibly involved in aromatic compounds catabolism
I6L37_17470	COG0247	lactate metabolic process
I6L37_17470	COG0277	FAD linked oxidase domain protein
I6L37_17480	COG1253	flavin adenine dinucleotide binding
I6L37_17485	COG1902	pentaerythritol trinitrate reductase activity
I6L37_17495	COG0647	UMP catabolic process
I6L37_17500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L37_17500	COG4651	solute:proton antiporter activity
I6L37_17510	COG0367	asparagine synthase
I6L37_17520	COG0625	glutathione transferase activity
I6L37_17545	COG0564	pseudouridine synthase activity
I6L37_17560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L37_17570	COG2431	L-lysine efflux transmembrane transporter activity
I6L37_17585	COG1393	Belongs to the ArsC family
I6L37_17595	COG4783	chaperone-mediated protein folding
I6L37_17600	COG0425	Belongs to the sulfur carrier protein TusA family
I6L37_17620	COG2326	polyphosphate kinase activity
I6L37_17630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L37_17635	COG1725	Transcriptional regulator
I6L37_17640	COG3842	ATPase activity
I6L37_17645	COG3833	ABC-type maltose transport systems, permease component
I6L37_17650	COG1175	transmembrane transport
I6L37_17660	COG3081	Nucleoid-associated protein
I6L37_17665	COG3082	Protein of unknown function (DUF1414)
I6L37_17670	COG3083	sulfuric ester hydrolase activity
I6L37_17675	COG1464	Belongs to the NlpA lipoprotein family
I6L37_17700	COG0574	Belongs to the PEP-utilizing enzyme family
I6L37_17700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L37_17705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L37_17715	COG1113	amino acid transport
I6L37_17725	COG3852	Histidine kinase
I6L37_17745	COG0641	radical SAM
I6L37_17755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L37_17755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L37_17760	COG0509	glycine decarboxylation via glycine cleavage system
I6L37_17765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L37_17770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L37_17775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L37_17780	COG3079	Belongs to the UPF0149 family
I6L37_17785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6L37_17795	COG0642	Histidine kinase
I6L37_17825	COG3302	dmso reductase anchor subunit
I6L37_17830	COG0437	4 iron, 4 sulfur cluster binding
I6L37_17835	COG0243	molybdopterin cofactor binding
I6L37_17845	COG3381	protein complex oligomerization
I6L37_17870	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6L37_17875	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6L37_17905	COG3118	belongs to the thioredoxin family
I6L37_17910	COG0492	ferredoxin-NADP+ reductase activity
I6L37_17915	COG1115	amino acid carrier protein
I6L37_17920	COG1115	amino acid carrier protein
I6L37_17925	COG1063	alcohol dehydrogenase
I6L37_17975	COG0582	viral genome integration into host DNA
I6L37_18000	COG0322	excinuclease ABC activity
I6L37_18005	COG2197	response regulator
I6L37_18010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L37_18015	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L37_18020	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L37_18025	COG1132	(ABC) transporter
I6L37_18030	COG2333	competence protein COMEC
I6L37_18030	COG0658	competence protein
I6L37_18045	COG0433	COG0433 Predicted ATPase
I6L37_18050	COG1448	Aminotransferase
I6L37_18060	COG0583	DNA-binding transcription factor activity
I6L37_18065	COG3085	chromosome segregation
I6L37_18070	COG4574	serine-type endopeptidase inhibitor activity
I6L37_18075	COG0584	glycerophosphoryl diester phosphodiesterase
I6L37_18085	COG1349	DNA-binding transcription factor activity
I6L37_18090	COG2271	Major facilitator Superfamily
I6L37_18095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L37_18100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L37_18105	COG0583	DNA-binding transcription factor activity
I6L37_18140	COG0656	L-ascorbic acid biosynthetic process
I6L37_18150	COG2814	Major facilitator Superfamily
I6L37_18160	COG2979	Protein of unknown function (DUF533)
I6L37_18190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L37_18235	COG4657	Part of a membrane complex involved in electron transport
I6L37_18240	COG2878	Part of a membrane complex involved in electron transport
I6L37_18250	COG4658	electron transport chain
I6L37_18255	COG4659	FMN binding
I6L37_18260	COG4660	Part of a membrane complex involved in electron transport
I6L37_18265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L37_18270	COG0346	lactoylglutathione lyase activity
I6L37_18300	COG3340	Belongs to the peptidase S51 family
I6L37_18315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L37_18320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L37_18325	COG0505	Belongs to the CarA family
I6L37_18330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L37_18340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L37_18345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L37_18350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L37_18355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L37_18360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L37_18365	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L37_18395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L37_18400	COG0861	Integral membrane protein TerC family
I6L37_18415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L37_18420	COG0601	transmembrane transport
I6L37_18430	COG2095	MarC family integral membrane protein
I6L37_18435	COG1012	belongs to the aldehyde dehydrogenase family
I6L37_18435	COG1454	alcohol dehydrogenase
I6L37_18440	COG0217	transcriptional regulatory protein
I6L37_18445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L37_18455	COG1801	Protein of unknown function DUF72
I6L37_18460	COG4106	trans-aconitate 2-methyltransferase activity
I6L37_18465	COG0500	methyltransferase
I6L37_18485	COG0450	alkyl hydroperoxide reductase
I6L37_18490	COG0583	DNA-binding transcription factor activity
I6L37_18495	COG0791	NLP P60 protein
I6L37_18505	COG0659	secondary active sulfate transmembrane transporter activity
I6L37_18510	COG0538	isocitrate dehydrogenase activity
I6L37_18515	COG2207	Transcriptional regulator
I6L37_18520	COG1482	cell wall glycoprotein biosynthetic process
I6L37_18525	COG3537	Alpha-1,2-mannosidase
I6L37_18570	COG4521	taurine ABC transporter
I6L37_18575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L37_18580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L37_18585	COG2175	clavaminate synthase activity
I6L37_18590	COG3152	Membrane
I6L37_18620	COG1309	transcriptional regulator
I6L37_18630	COG1454	alcohol dehydrogenase
I6L37_18650	COG0534	Mate efflux family protein
I6L37_18660	COG2841	Protein conserved in bacteria
I6L37_18665	COG1653	transport
I6L37_18670	COG5001	Diguanylate cyclase
I6L37_18670	COG5002	protein histidine kinase activity
I6L37_18675	COG3132	Protein of unknown function, DUF480
I6L37_18705	COG0708	Exodeoxyribonuclease III
I6L37_18725	COG1122	ATPase activity
I6L37_18730	COG1122	ATPase activity
I6L37_18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_18755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L37_18765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L37_18770	COG1120	ATPase activity
I6L37_18775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L37_18780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L37_18785	COG4771	TonB-dependent receptor
I6L37_18790	COG2375	cellular response to nickel ion
I6L37_18795	COG0784	Response regulator, receiver
I6L37_18795	COG3437	response regulator, receiver
I6L37_18805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L37_18810	COG0328	RNA-DNA hybrid ribonuclease activity
I6L37_18815	COG2226	methyltransferase
I6L37_18820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L37_18825	COG1388	LysM domain
I6L37_18825	COG0741	lytic transglycosylase activity
I6L37_18845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L37_18900	COG3829	transcription factor binding
I6L37_18960	COG0471	metal ion transport
I6L37_18970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L37_18980	COG4134	Bacterial extracellular solute-binding protein
I6L37_18985	COG4135	transport system, permease component
I6L37_18990	COG4136	ATPase activity
I6L37_18995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L37_19000	COG2951	lytic endotransglycosylase activity
I6L37_19015	COG0033	Phosphoglucomutase
I6L37_19020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L37_19025	COG0596	Alpha beta hydrolase
I6L37_19040	COG0716	FMN binding
I6L37_19050	COG0735	belongs to the Fur family
I6L37_19055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L37_19065	COG1263	PTS System
I6L37_19065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L37_19065	COG2190	(PTS) system
I6L37_19070	COG0363	glucosamine-6-phosphate deaminase activity
I6L37_19075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L37_19080	COG1940	carbohydrate kinase activity
I6L37_19080	COG1846	Transcriptional regulator
I6L37_19085	COG2194	sulfuric ester hydrolase activity
I6L37_19095	COG3275	phosphorelay sensor kinase activity
I6L37_19100	COG3279	Response regulator of the LytR AlgR family
I6L37_19105	COG1966	Carbon starvation protein
I6L37_19115	COG1566	PFAM secretion protein HlyD family protein
I6L37_19120	COG1061	Type III restriction enzyme res subunit
I6L37_19125	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L37_19130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L37_19140	COG3021	interspecies interaction between organisms
I6L37_19150	COG1607	acyl-coa hydrolase
I6L37_19155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L37_19165	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L37_19165	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L37_19165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L37_19165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L37_19175	COG0633	Ferredoxin
I6L37_19175	COG3217	Mosc domain protein beta barrel domain protein
I6L37_19175	COG0633	Ferredoxin
I6L37_19175	COG3217	Mosc domain protein beta barrel domain protein
I6L37_19185	COG0501	Belongs to the peptidase M48B family
I6L37_19190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L37_19195	COG1073	alpha beta
I6L37_19195	COG2226	methyltransferase
I6L37_19200	COG0156	8-amino-7-oxononanoate synthase activity
I6L37_19205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L37_19225	COG0017	Asparaginyl-tRNA synthetase
I6L37_19230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L37_19240	COG1473	amidohydrolase
I6L37_19245	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L37_19255	COG1393	Belongs to the ArsC family
I6L37_19260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L37_19265	COG1876	peptidase activity
I6L37_19280	COG3263	regulation of cellular component size
I6L37_19290	COG3263	regulation of cellular component size
I6L37_19295	COG1280	lysine exporter protein (LysE YggA)
I6L37_19400	COG4397	Mu-like prophage major head subunit gpT
I6L37_19405	COG4388	Caudovirus prohead serine protease
I6L37_19425	COG4383	Mu-like prophage protein gp29
I6L37_19430	COG4373	Mu-like prophage FluMu protein gp28
I6L37_19440	COG0640	Transcriptional regulator
I6L37_19550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L37_19555	COG0702	epimerase
I6L37_19565	COG0095	Lipoate-protein ligase
I6L37_19595	COG0640	Transcriptional regulator
I6L37_19610	COG1285	pathogenesis
I6L37_19640	COG0484	heat shock protein binding
I6L37_19645	COG0443	Heat shock 70 kDa protein
I6L37_19650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L37_19655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L37_19660	COG0583	DNA-binding transcription factor activity
I6L37_19665	COG1486	melibiose metabolic process
I6L37_19670	COG0497	DNA recombination
I6L37_19680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_19685	COG0577	efflux transmembrane transporter activity
I6L37_19685	COG1136	(ABC) transporter
I6L37_19695	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L37_19705	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L37_19715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L37_19720	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L37_19725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L37_19740	COG0662	Cupin 2, conserved barrel domain protein
I6L37_19740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6L37_19750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L37_19755	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6L37_19780	COG5433	transposase activity
I6L37_19785	COG5433	transposase activity
I6L37_19795	COG5433	transposase activity
I6L37_19815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L37_19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L37_19825	COG1309	transcriptional regulator
I6L37_19840	COG1342	Belongs to the UPF0251 family
I6L37_19860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L37_19865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L37_19865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L37_19865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L37_19875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L37_19885	COG1187	pseudouridine synthase activity
I6L37_19895	COG0482	sulfurtransferase activity
I6L37_19900	COG2915	High frequency lysogenization protein hflD homolog
I6L37_19905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L37_19910	COG2850	peptidyl-arginine hydroxylation
I6L37_19920	COG3153	acetyltransferase
I6L37_19925	COG0625	glutathione transferase activity
I6L37_19930	COG0259	pyridoxamine-phosphate oxidase activity
I6L37_19945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L37_19945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L37_19950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L37_19975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L37_19980	COG1138	Cytochrome C-type biogenesis protein
I6L37_19985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L37_19990	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L37_19995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L37_20000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L37_20005	COG4133	protoheme IX ABC transporter activity
I6L37_20015	COG0835	chemotaxis
I6L37_20025	COG1192	Involved in chromosome partitioning
I6L37_20030	COG1360	Flagellar Motor Protein
I6L37_20035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L37_20040	COG2201	protein-glutamate methylesterase activity
I6L37_20045	COG2198	Histidine kinase
I6L37_20045	COG0784	Response regulator, receiver
I6L37_20045	COG0643	Histidine kinase
I6L37_20050	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L37_20075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L37_20085	COG1684	flagellar biosynthetic protein fliR
I6L37_20140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L37_20150	COG1677	Flagellar hook-basal body complex protein FliE
I6L37_20165	COG0469	pyruvate kinase activity
I6L37_20170	COG1737	Transcriptional regulator
I6L37_20175	COG0837	glucose binding
I6L37_20190	COG2233	PERMEase
I6L37_20205	COG0281	malic enzyme
I6L37_20215	COG0437	4 iron, 4 sulfur cluster binding
I6L37_20220	COG3383	formate dehydrogenase (NAD+) activity
I6L37_20220	COG3383	formate dehydrogenase (NAD+) activity
I6L37_20275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L37_20280	COG1910	domain protein
I6L37_20285	COG3852	Histidine kinase
I6L37_20290	COG2204	response regulator
I6L37_20300	COG4662	Binding-protein-dependent transport system inner membrane component
I6L37_20310	COG0746	molybdenum cofactor guanylyltransferase activity
I6L37_20315	COG0303	'Molybdopterin
I6L37_20320	COG1289	transmembrane transporter activity
I6L37_20350	COG3220	belongs to the UPF0276 family
I6L37_20390	COG2205	protein histidine kinase activity
I6L37_20390	COG0784	Response regulator, receiver
I6L37_20400	COG0601	transmembrane transport
I6L37_20405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L37_20410	COG0444	Belongs to the ABC transporter superfamily
I6L37_20415	COG4608	Belongs to the ABC transporter superfamily
I6L37_20425	COG2971	BadF BadG BcrA BcrD
I6L37_20435	COG0840	transmembrane signaling receptor activity
I6L37_20455	COG3724	N-succinylarginine dihydrolase activity
I6L37_20480	COG0826	peptidase U32
I6L37_20485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L37_20495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L37_20500	COG3706	GGDEF domain
I6L37_20505	COG2211	Major facilitator Superfamily
I6L37_20510	COG0616	signal peptide processing
I6L37_20515	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_20520	COG0583	DNA-binding transcription factor activity
I6L37_20530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L37_20545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L37_20550	COG1881	PFAM PEBP family protein
I6L37_20565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L37_20575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L37_20580	COG2912	Transglutaminase-like superfamily
I6L37_20590	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L37_20595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L37_20600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L37_20605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L37_20610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L37_20620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L37_20625	COG0737	Belongs to the 5'-nucleotidase family
I6L37_20630	COG0193	aminoacyl-tRNA hydrolase activity
I6L37_20635	COG0012	GTP binding
I6L37_20645	COG5377	YqaJ viral recombinase family
I6L37_20690	COG2003	Belongs to the UPF0758 family
I6L37_20760	COG4584	PFAM Integrase catalytic
I6L37_20765	COG1484	DNA-dependent DNA replication
I6L37_20770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L37_20855	COG0490	domain, Protein
I6L37_20855	COG0471	metal ion transport
I6L37_20890	COG2214	Heat shock protein DnaJ domain protein
I6L37_20895	COG0443	Heat shock 70 kDa protein
I6L37_20905	COG0488	(ABC) transporter
I6L37_20920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_20935	COG1012	belongs to the aldehyde dehydrogenase family
I6L37_20945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L37_20960	COG0180	Tryptophanyl-tRNA synthetase
I6L37_20970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L37_20975	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L37_20985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L37_20990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L37_21020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L37_21025	COG0583	DNA-binding transcription factor activity
I6L37_21045	COG0583	DNA-binding transcription factor activity
I6L37_21055	COG0739	heme binding
I6L37_21065	COG3264	Mechanosensitive ion channel
I6L37_21065	COG1511	domain protein
I6L37_21070	COG0584	glycerophosphoryl diester phosphodiesterase
I6L37_21080	COG1053	succinate dehydrogenase
I6L37_21085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L37_21090	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L37_21095	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L37_21105	COG3366	ferrous iron transmembrane transporter activity
I6L37_21110	COG0700	Nucleoside recognition
I6L37_21115	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L37_21125	COG3214	Protein conserved in bacteria
I6L37_21150	COG0300	oxidoreductase activity
I6L37_21165	COG0642	Histidine kinase
I6L37_21170	COG4067	protein conserved in archaea
I6L37_21170	COG0189	ligase activity
I6L37_21175	COG0516	GMP reductase activity
I6L37_21185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L37_21195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L37_21210	COG2199	diguanylate cyclase activity
I6L37_21215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L37_21235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L37_21240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L37_21245	COG1702	phosphate starvation-inducible protein PhoH
I6L37_21250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L37_21255	COG4535	Mg2 and Co2 transporter CorC
I6L37_21260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L37_21270	COG0789	Transcriptional regulator
I6L37_21285	COG1970	mechanosensitive ion channel activity
I6L37_21295	COG4974	Belongs to the 'phage' integrase family
I6L37_21310	COG0312	modulator of DNA gyrase
I6L37_21315	COG2888	peptidyl-tyrosine sulfation
I6L37_21320	COG0495	leucyl-tRNA aminoacylation
I6L37_21335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L37_21340	COG0799	negative regulation of ribosome biogenesis
I6L37_21345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L37_21350	COG0768	penicillin binding
I6L37_21355	COG0772	Belongs to the SEDS family
I6L37_21360	COG2951	lytic endotransglycosylase activity
I6L37_21365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L37_21370	COG1686	Belongs to the peptidase S11 family
I6L37_21375	COG2921	Belongs to the UPF0250 family
I6L37_21380	COG0321	lipoyl(octanoyl) transferase activity
I6L37_21385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L37_21405	COG3139	Protein of unknown function (DUF1315)
I6L37_21410	COG0252	asparaginase activity
I6L37_21415	COG0786	glutamate:sodium symporter activity
I6L37_21430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L37_21435	COG0384	phenazine biosynthesis protein PhzF
I6L37_21445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L37_21450	COG0175	sulfate reduction
I6L37_21455	COG2113	Glycine betaine
I6L37_21460	COG4176	ABC-type proline glycine betaine transport system permease component
I6L37_21465	COG4175	Glycine betaine
I6L37_21480	COG2966	Psort location CytoplasmicMembrane, score
I6L37_21490	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L37_21510	COG2897	thiosulfate sulfurtransferase activity
I6L37_21515	COG2066	Belongs to the glutaminase family
I6L37_21520	COG3171	Protein conserved in bacteria
I6L37_21525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L37_21530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L37_21535	COG1090	epimerase
I6L37_21540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L37_21545	COG4181	ATPase activity
I6L37_21550	COG2755	lipolytic protein G-D-S-L family
I6L37_21555	COG0835	chemotaxis
I6L37_21555	COG0784	Response regulator, receiver
I6L37_21600	COG2205	protein histidine kinase activity
I6L37_21605	COG2814	Major facilitator Superfamily
I6L37_21615	COG3179	chitinase
I6L37_21660	COG0748	coenzyme F420 binding
I6L37_21665	COG3721	Heme iron utilization protein
I6L37_21675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L37_21700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L37_21715	COG0737	Belongs to the 5'-nucleotidase family
I6L37_21735	COG2204	response regulator
I6L37_21740	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L37_21755	COG1047	Peptidyl-prolyl cis-trans
I6L37_21760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L37_21770	COG0784	Response regulator, receiver
I6L37_21770	COG0835	chemotaxis
I6L37_21775	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L37_21780	COG3089	Belongs to the UPF0270 family
I6L37_21785	COG3954	Phosphoribulokinase
I6L37_21800	COG1765	OsmC-like protein
I6L37_21810	COG2226	methyltransferase
I6L37_21840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L37_21840	COG1522	sequence-specific DNA binding
I6L37_21845	COG2313	pseudouridylate synthase activity
I6L37_21880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L37_21890	COG0318	PFAM AMP-dependent synthetase and ligase
I6L37_21895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L37_21940	COG1028	Short-chain dehydrogenase reductase Sdr
I6L37_21945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L37_21955	COG1858	cytochrome C peroxidase
I6L37_21980	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L37_21985	COG5001	Diguanylate cyclase
I6L37_21985	COG3300	MHYT domain