locus-tag	class	description
I6L38_00005	COG2927	DNA polymerase III (CHI subunit)
I6L38_00010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L38_00015	COG0795	lipopolysaccharide-transporting ATPase activity
I6L38_00020	COG0795	lipopolysaccharide-transporting ATPase activity
I6L38_00035	COG0004	ammonium transporteR
I6L38_00040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L38_00055	COG2165	general secretion pathway protein
I6L38_00060	COG0084	hydrolase, TatD family'
I6L38_00065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L38_00075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L38_00080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L38_00085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L38_00090	COG0813	purine-nucleoside phosphorylase activity
I6L38_00095	COG5001	Diguanylate cyclase
I6L38_00095	COG3447	MASE1 domain protein
I6L38_00095	COG5002	protein histidine kinase activity
I6L38_00105	COG0560	Phosphoserine phosphatase
I6L38_00140	COG0776	regulation of translation
I6L38_00155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L38_00160	COG0735	belongs to the Fur family
I6L38_00185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L38_00190	COG0513	Belongs to the DEAD box helicase family
I6L38_00195	COG3022	response to hydroperoxide
I6L38_00210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L38_00215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L38_00220	COG0762	integral membrane protein
I6L38_00225	COG1872	DUF167
I6L38_00240	COG4166	transmembrane transport
I6L38_00250	COG0110	maltose O-acetyltransferase activity
I6L38_00260	COG1024	Enoyl-CoA hydratase
I6L38_00275	COG4221	oxidoreductase activity
I6L38_00280	COG0442	prolyl-tRNA aminoacylation
I6L38_00285	COG0840	transmembrane signaling receptor activity
I6L38_00290	COG0632	four-way junction helicase activity
I6L38_00295	COG2255	four-way junction helicase activity
I6L38_00300	COG1271	oxidase subunit
I6L38_00305	COG1294	oxidase, subunit
I6L38_00310	COG4890	Cyd operon protein YbgT
I6L38_00315	COG3790	cyd operon protein YbgE
I6L38_00320	COG0824	Thioesterase
I6L38_00325	COG0811	peptide transport
I6L38_00340	COG0823	Involved in the tonB-independent uptake of proteins
I6L38_00345	COG2885	chlorophyll binding
I6L38_00350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L38_00425	COG0840	transmembrane signaling receptor activity
I6L38_00430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L38_00435	COG0676	glucose-6-phosphate 1-epimerase activity
I6L38_00440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L38_00445	COG1640	4-alpha-glucanotransferase
I6L38_00450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L38_00470	COG1051	belongs to the nudix hydrolase family
I6L38_00475	COG2130	NADP-dependent
I6L38_00480	COG1846	Transcriptional regulator
I6L38_00510	COG0561	phosphatase activity
I6L38_00525	COG0733	neurotransmitter:sodium symporter activity
I6L38_00535	COG0733	neurotransmitter:sodium symporter activity
I6L38_00560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L38_00575	COG1794	racemase activity, acting on amino acids and derivatives
I6L38_00580	COG2132	Multicopper oxidase
I6L38_00590	COG2731	YhcH YjgK YiaL family protein
I6L38_00600	COG0668	transmembrane transport
I6L38_00610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L38_00645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L38_00655	COG0488	(ABC) transporter
I6L38_00660	COG0517	IMP dehydrogenase activity
I6L38_00660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L38_00665	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L38_00670	COG0330	HflC and HflK could
I6L38_00675	COG1648	precorrin-2 dehydrogenase activity
I6L38_00675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L38_00680	COG0175	sulfate reduction
I6L38_00685	COG2895	sulfate adenylyltransferase (ATP) activity
I6L38_00690	COG3273	potassium ion transport
I6L38_00690	COG0471	metal ion transport
I6L38_00695	COG0529	Catalyzes the synthesis of activated sulfate
I6L38_00740	COG0840	transmembrane signaling receptor activity
I6L38_00760	COG1136	(ABC) transporter
I6L38_00775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L38_00790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L38_00795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L38_00800	COG0163	prenyltransferase activity
I6L38_00815	COG1131	(ABC) transporter
I6L38_00820	COG0842	Transport permease protein
I6L38_00825	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6L38_00830	COG1924	4 iron, 4 sulfur cluster binding
I6L38_00850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L38_00855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L38_00860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L38_00870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L38_00875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L38_00880	COG1489	DNA binding
I6L38_00890	COG1643	Atp-dependent helicase
I6L38_00895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L38_00900	COG0346	lactoylglutathione lyase activity
I6L38_00910	COG2076	Multidrug Resistance protein
I6L38_00920	COG3437	response regulator, receiver
I6L38_00920	COG0784	Response regulator, receiver
I6L38_00930	COG0671	phosphoesterase, PA-phosphatase related
I6L38_00945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L38_00950	COG0038	chloride channel
I6L38_00960	COG0316	Belongs to the HesB IscA family
I6L38_00990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L38_01005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_01035	COG0745	RESPONSE REGULATOR receiver
I6L38_01040	COG3104	oligopeptide transport
I6L38_01045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L38_01050	COG1555	photosystem II stabilization
I6L38_01060	COG2350	Protein conserved in bacteria
I6L38_01065	COG2917	probably involved in intracellular septation
I6L38_01070	COG0076	glutamate decarboxylase activity
I6L38_01075	COG1272	protein, Hemolysin III
I6L38_01080	COG2985	domain, Protein
I6L38_01080	COG0569	domain protein
I6L38_01150	COG0564	pseudouridine synthase activity
I6L38_01155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L38_01190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L38_01200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L38_01205	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L38_01215	COG4143	(ABC) transporter
I6L38_01230	COG0066	3-isopropylmalate dehydratase activity
I6L38_01235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L38_01240	COG0473	3-isopropylmalate dehydrogenase activity
I6L38_01245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L38_01255	COG0671	phosphoesterase, PA-phosphatase related
I6L38_01270	COG0028	Belongs to the TPP enzyme family
I6L38_01275	COG0440	acetolactate synthase activity
I6L38_01280	COG0857	belongs to the CobB CobQ family
I6L38_01280	COG0280	phosphate acetyltransferase
I6L38_01285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L38_01295	COG3013	Belongs to the UPF0304 family
I6L38_01300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L38_01305	COG2716	regulation of RNA biosynthetic process
I6L38_01315	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L38_01320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L38_01335	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L38_01355	COG0784	Response regulator, receiver
I6L38_01355	COG2198	Histidine kinase
I6L38_01355	COG5002	protein histidine kinase activity
I6L38_01380	COG0840	transmembrane signaling receptor activity
I6L38_01390	COG1464	Belongs to the NlpA lipoprotein family
I6L38_01395	COG2011	ABC-type metal ion transport system permease component
I6L38_01400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L38_01420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L38_01420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L38_01425	COG0802	atpase or kinase
I6L38_01435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L38_01440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L38_01445	COG1923	regulation of RNA biosynthetic process
I6L38_01450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L38_01455	COG0330	HflC and HflK could
I6L38_01460	COG0330	HflC and HflK could
I6L38_01465	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L38_01470	COG0142	geranyltranstransferase activity
I6L38_01475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L38_01480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L38_01485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L38_01490	COG3314	Sporulation integral membrane protein YlbJ
I6L38_01495	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_01510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L38_01515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L38_01525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L38_01530	COG2967	ApaG domain
I6L38_01535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L38_01540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L38_01550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L38_01555	COG3178	'Phosphotransferase
I6L38_01560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L38_01565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L38_01570	COG2252	PERMEase
I6L38_01580	COG0488	(ABC) transporter
I6L38_01585	COG0582	viral genome integration into host DNA
I6L38_01595	COG0629	single-stranded DNA binding
I6L38_01675	COG1846	Transcriptional regulator
I6L38_01805	COG1802	Transcriptional regulator
I6L38_01805	COG4626	Terminase
I6L38_01820	COG0616	signal peptide processing
I6L38_01860	COG4386	tail sheath protein
I6L38_01900	COG3299	homolog of phage Mu protein gp47
I6L38_01905	COG3778	Protein conserved in bacteria
I6L38_01955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L38_01960	COG0741	lytic transglycosylase activity
I6L38_01985	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6L38_01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L38_02000	COG3721	Heme iron utilization protein
I6L38_02005	COG0748	coenzyme F420 binding
I6L38_02025	COG4771	TonB-dependent receptor
I6L38_02030	COG2814	Major facilitator Superfamily
I6L38_02040	COG3655	Transcriptional regulator
I6L38_02050	COG2205	protein histidine kinase activity
I6L38_02050	COG2202	Pas domain
I6L38_02065	COG3397	chitin binding
I6L38_02080	COG1765	OsmC-like protein
I6L38_02095	COG3954	Phosphoribulokinase
I6L38_02100	COG2076	Multidrug Resistance protein
I6L38_02105	COG2076	Multidrug Resistance protein
I6L38_02110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L38_02115	COG0726	polysaccharide deacetylase
I6L38_02120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L38_02120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L38_02125	COG0463	Glycosyl transferase, family 2
I6L38_02130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L38_02140	COG3089	Belongs to the UPF0270 family
I6L38_02145	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L38_02150	COG0784	Response regulator, receiver
I6L38_02150	COG0835	chemotaxis
I6L38_02160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L38_02165	COG1047	Peptidyl-prolyl cis-trans
I6L38_02170	COG2900	Belongs to the SlyX family
I6L38_02180	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L38_02185	COG2204	response regulator
I6L38_02205	COG0737	Belongs to the 5'-nucleotidase family
I6L38_02210	COG2200	EAL domain
I6L38_02225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L38_02230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_02235	COG0826	peptidase U32
I6L38_02240	COG2199	diguanylate cyclase activity
I6L38_02240	COG2200	EAL domain
I6L38_02240	COG2203	Gaf domain
I6L38_02265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L38_02270	COG2201	protein-glutamate methylesterase activity
I6L38_02275	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6L38_02285	COG0840	transmembrane signaling receptor activity
I6L38_02290	COG0835	chemotaxis
I6L38_02300	COG2198	Histidine kinase
I6L38_02300	COG0643	Histidine kinase
I6L38_02310	COG0745	RESPONSE REGULATOR receiver
I6L38_02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L38_02330	COG1280	lysine exporter protein (LysE YggA)
I6L38_02335	COG0826	peptidase U32
I6L38_02365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L38_02390	COG0300	oxidoreductase activity
I6L38_02400	COG0840	transmembrane signaling receptor activity
I6L38_02430	COG1605	Chorismate mutase
I6L38_02430	COG0077	Prephenate dehydratase
I6L38_02460	COG3272	Protein of unknown function (DUF1722)
I6L38_02465	COG0789	Transcriptional regulator
I6L38_02470	COG0415	Belongs to the DNA photolyase family
I6L38_02480	COG0300	oxidoreductase activity
I6L38_02495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L38_02520	COG0783	Belongs to the Dps family
I6L38_02525	COG1151	hydroxylamine reductase activity
I6L38_02535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L38_02540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L38_02540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L38_02550	COG2771	luxR family
I6L38_02600	COG0693	protein deglycase activity
I6L38_02605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L38_02610	COG1666	GTP binding
I6L38_02615	COG3248	Nucleoside-binding outer membrane protein
I6L38_02620	COG2211	Major facilitator Superfamily
I6L38_02630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L38_02640	COG2813	Specifically methylates the guanine in position
I6L38_02645	COG0271	Belongs to the BolA IbaG family
I6L38_02650	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L38_02655	COG1805	sodium ion transport
I6L38_02660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L38_02665	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L38_02670	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L38_02675	COG2871	sodium ion transport
I6L38_02680	COG1477	protein flavinylation
I6L38_02695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L38_02700	COG0840	transmembrane signaling receptor activity
I6L38_02705	COG0583	DNA-binding transcription factor activity
I6L38_02715	COG2363	Small membrane protein
I6L38_02720	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L38_02730	COG0473	3-isopropylmalate dehydrogenase activity
I6L38_02735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L38_02740	COG1611	Belongs to the LOG family
I6L38_02755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L38_02755	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L38_02765	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L38_02790	COG3098	single-species biofilm formation
I6L38_02795	COG0564	pseudouridine synthase activity
I6L38_02815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_02815	COG1263	PTS System
I6L38_02825	COG2171	N-acyltransferase activity
I6L38_02830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L38_02835	COG0024	Methionine aminopeptidase
I6L38_02840	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L38_02845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L38_02850	COG0528	UMP kinase activity
I6L38_02855	COG0233	cytoplasmic translational termination
I6L38_02860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L38_02865	COG0575	Belongs to the CDS family
I6L38_02870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L38_02875	COG0750	zinc metalloprotease
I6L38_02890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L38_02895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L38_02900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L38_02905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L38_02910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L38_02920	COG0825	malonyl-CoA metabolic process
I6L38_02925	COG3710	Transcriptional regulator
I6L38_02930	COG0531	amino acid
I6L38_02935	COG1982	Orn Lys Arg decarboxylase major
I6L38_02940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L38_02955	COG0814	amino acid
I6L38_02960	COG0531	amino acid
I6L38_02970	COG0488	(ABC) transporter
I6L38_02980	COG3590	peptidase
I6L38_02990	COG3706	GGDEF domain
I6L38_03025	COG0366	Alpha amylase catalytic
I6L38_03040	COG0463	Glycosyl transferase, family 2
I6L38_03055	COG2989	Protein conserved in bacteria
I6L38_03060	COG3108	Peptidase M15
I6L38_03070	COG2860	membrane
I6L38_03080	COG1196	nuclear chromosome segregation
I6L38_03085	COG3115	cell septum assembly
I6L38_03090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L38_03100	COG1328	CTP reductase activity
I6L38_03105	COG0602	queuosine metabolic process
I6L38_03135	COG1566	PFAM secretion protein HlyD family protein
I6L38_03140	COG1846	Transcriptional regulator
I6L38_03155	COG0281	malic enzyme
I6L38_03160	COG3290	protein histidine kinase activity
I6L38_03165	COG4565	transcriptional regulatory protein
I6L38_03170	COG0697	spore germination
I6L38_03185	COG3284	Transcriptional regulator
I6L38_03190	COG1960	acyl-CoA dehydrogenase activity
I6L38_03195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L38_03200	COG0346	lactoylglutathione lyase activity
I6L38_03205	COG0745	RESPONSE REGULATOR receiver
I6L38_03210	COG5002	protein histidine kinase activity
I6L38_03235	COG3142	Participates in the control of copper homeostasis
I6L38_03240	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L38_03245	COG1131	(ABC) transporter
I6L38_03260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_03265	COG4597	amino acid ABC transporter
I6L38_03270	COG0765	amino acid transport
I6L38_03275	COG1126	abc transporter atp-binding protein
I6L38_03305	COG0019	diaminopimelate decarboxylase activity
I6L38_03310	COG1115	amino acid carrier protein
I6L38_03315	COG0095	Lipoate-protein ligase
I6L38_03320	COG2233	PERMEase
I6L38_03335	COG0534	Mate efflux family protein
I6L38_03340	COG2207	Transcriptional regulator
I6L38_03345	COG0281	malic enzyme
I6L38_03375	COG0733	neurotransmitter:sodium symporter activity
I6L38_03380	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L38_03390	COG1566	PFAM secretion protein HlyD family protein
I6L38_03395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L38_03405	COG1032	radical SAM domain protein
I6L38_03415	COG1280	lysine exporter protein (LysE YggA)
I6L38_03420	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_03455	COG3152	Membrane
I6L38_03480	COG0673	inositol 2-dehydrogenase activity
I6L38_03485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L38_03490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L38_03495	COG0739	heme binding
I6L38_03495	COG0741	lytic transglycosylase activity
I6L38_03495	COG1196	nuclear chromosome segregation
I6L38_03500	COG0366	Alpha amylase catalytic
I6L38_03520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L38_03530	COG0788	formyltetrahydrofolate deformylase activity
I6L38_03535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L38_03545	COG3118	belongs to the thioredoxin family
I6L38_03550	COG2091	lysine biosynthetic process via aminoadipic acid
I6L38_03555	COG0791	NLP P60 protein
I6L38_03560	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L38_03575	COG1376	ErfK ybiS ycfS ynhG family protein
I6L38_03575	COG1388	LysM domain
I6L38_03595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L38_03600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_03610	COG5002	protein histidine kinase activity
I6L38_03625	COG0583	DNA-binding transcription factor activity
I6L38_03630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L38_03635	COG0243	molybdopterin cofactor binding
I6L38_03680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L38_03690	COG1960	acyl-CoA dehydrogenase activity
I6L38_03705	COG0469	pyruvate kinase activity
I6L38_03710	COG1737	Transcriptional regulator
I6L38_03730	COG2274	protein secretion by the type I secretion system
I6L38_03740	COG2274	protein secretion by the type I secretion system
I6L38_03750	COG2994	toxin metabolic process
I6L38_03755	COG1073	alpha beta
I6L38_03755	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6L38_03755	COG3064	Membrane
I6L38_03760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L38_03805	COG1342	Belongs to the UPF0251 family
I6L38_03810	COG0640	Transcriptional regulator
I6L38_03825	COG0798	PFAM Bile acid sodium symporter
I6L38_03830	COG1393	Belongs to the ArsC family
I6L38_03845	COG1677	Flagellar hook-basal body complex protein FliE
I6L38_03855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L38_03910	COG1684	flagellar biosynthetic protein fliR
I6L38_03920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L38_03945	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L38_03950	COG0643	Histidine kinase
I6L38_03950	COG2198	Histidine kinase
I6L38_03950	COG0784	Response regulator, receiver
I6L38_03955	COG2201	protein-glutamate methylesterase activity
I6L38_03960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L38_03970	COG1192	Involved in chromosome partitioning
I6L38_03980	COG0835	chemotaxis
I6L38_03995	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L38_04000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L38_04005	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L38_04010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L38_04015	COG1138	Cytochrome C-type biogenesis protein
I6L38_04020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L38_04025	COG3088	subunit of a heme lyase
I6L38_04025	COG4235	cytochrome complex assembly
I6L38_04045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L38_04050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L38_04050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L38_04065	COG0259	pyridoxamine-phosphate oxidase activity
I6L38_04070	COG0625	glutathione transferase activity
I6L38_04080	COG3153	acetyltransferase
I6L38_04090	COG2850	peptidyl-arginine hydroxylation
I6L38_04100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L38_04105	COG2915	High frequency lysogenization protein hflD homolog
I6L38_04110	COG0482	sulfurtransferase activity
I6L38_04120	COG1187	pseudouridine synthase activity
I6L38_04130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_04130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_04130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_04140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_04140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_04150	COG0456	acetyltransferase
I6L38_04160	COG0789	Transcriptional regulator
I6L38_04165	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L38_04165	COG1902	pentaerythritol trinitrate reductase activity
I6L38_04170	COG1609	Transcriptional regulator
I6L38_04175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_04175	COG1263	PTS System
I6L38_04180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L38_04190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_04210	COG2207	Transcriptional regulator
I6L38_04215	COG0538	isocitrate dehydrogenase activity
I6L38_04220	COG0659	secondary active sulfate transmembrane transporter activity
I6L38_04230	COG3048	D-serine ammonia-lyase activity
I6L38_04235	COG0583	DNA-binding transcription factor activity
I6L38_04240	COG1940	carbohydrate kinase activity
I6L38_04245	COG0514	ATP-dependent DNA helicase (RecQ)
I6L38_04250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L38_04265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L38_04270	COG2867	negative regulation of translational initiation
I6L38_04275	COG2914	Belongs to the UPF0125 (RnfH) family
I6L38_04280	COG0702	epimerase
I6L38_04285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L38_04290	COG1454	alcohol dehydrogenase
I6L38_04300	COG0564	pseudouridine synthase activity
I6L38_04305	COG1957	nucleoside hydrolase
I6L38_04330	COG1280	lysine exporter protein (LysE YggA)
I6L38_04350	COG3263	regulation of cellular component size
I6L38_04360	COG1876	peptidase activity
I6L38_04365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L38_04370	COG1393	Belongs to the ArsC family
I6L38_04375	COG0583	DNA-binding transcription factor activity
I6L38_04385	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L38_04400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L38_04405	COG0017	Asparaginyl-tRNA synthetase
I6L38_04425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L38_04430	COG0156	8-amino-7-oxononanoate synthase activity
I6L38_04435	COG1073	alpha beta
I6L38_04435	COG2226	methyltransferase
I6L38_04440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L38_04445	COG0501	Belongs to the peptidase M48B family
I6L38_04455	COG3217	Mosc domain protein beta barrel domain protein
I6L38_04455	COG0633	Ferredoxin
I6L38_04455	COG3217	Mosc domain protein beta barrel domain protein
I6L38_04455	COG0633	Ferredoxin
I6L38_04465	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L38_04465	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L38_04465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L38_04465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L38_04470	COG2366	antibiotic biosynthetic process
I6L38_04475	COG1917	Cupin 2, conserved barrel domain protein
I6L38_04475	COG2169	Transcriptional regulator
I6L38_04480	COG2841	Protein conserved in bacteria
I6L38_04490	COG0534	Mate efflux family protein
I6L38_04530	COG1309	transcriptional regulator
I6L38_04545	COG0791	NLP P60 protein
I6L38_04555	COG0583	DNA-binding transcription factor activity
I6L38_04560	COG0450	alkyl hydroperoxide reductase
I6L38_04580	COG0500	methyltransferase
I6L38_04585	COG4106	trans-aconitate 2-methyltransferase activity
I6L38_04590	COG1801	Protein of unknown function DUF72
I6L38_04595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L38_04600	COG0217	transcriptional regulatory protein
I6L38_04605	COG2194	sulfuric ester hydrolase activity
I6L38_04610	COG1940	carbohydrate kinase activity
I6L38_04610	COG1846	Transcriptional regulator
I6L38_04615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L38_04620	COG0363	glucosamine-6-phosphate deaminase activity
I6L38_04625	COG1263	PTS System
I6L38_04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_04625	COG2190	(PTS) system
I6L38_04635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L38_04640	COG0735	belongs to the Fur family
I6L38_04650	COG0716	FMN binding
I6L38_04665	COG0596	Alpha beta hydrolase
I6L38_04670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L38_04675	COG0033	Phosphoglucomutase
I6L38_04685	COG1846	Transcriptional regulator
I6L38_04700	COG2951	lytic endotransglycosylase activity
I6L38_04705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L38_04710	COG4136	ATPase activity
I6L38_04720	COG4134	Bacterial extracellular solute-binding protein
I6L38_04730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L38_04740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L38_04745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L38_04755	COG0729	surface antigen
I6L38_04760	COG2911	Protein conserved in bacteria
I6L38_04780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L38_04790	COG0741	lytic transglycosylase activity
I6L38_04805	COG1607	acyl-coa hydrolase
I6L38_04815	COG3021	interspecies interaction between organisms
I6L38_04820	COG1388	LysM domain
I6L38_04820	COG0741	lytic transglycosylase activity
I6L38_04825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L38_04830	COG2226	methyltransferase
I6L38_04835	COG0328	RNA-DNA hybrid ribonuclease activity
I6L38_04840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L38_04850	COG0784	Response regulator, receiver
I6L38_04850	COG3437	response regulator, receiver
I6L38_04855	COG1960	acyl-CoA dehydrogenase activity
I6L38_04860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L38_04865	COG0121	glutamine amidotransferase
I6L38_04885	COG0784	Response regulator, receiver
I6L38_04885	COG2205	protein histidine kinase activity
I6L38_04895	COG2197	response regulator
I6L38_04900	COG3850	Histidine kinase
I6L38_04905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L38_04910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_04910	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_04920	COG0243	molybdopterin cofactor binding
I6L38_04925	COG0437	4 iron, 4 sulfur cluster binding
I6L38_04930	COG0348	domain, Protein
I6L38_04940	COG3005	denitrification pathway
I6L38_04945	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L38_04950	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L38_04955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L38_04960	COG0314	molybdopterin synthase activity
I6L38_04975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L38_04980	COG2267	carboxylic ester hydrolase activity
I6L38_04985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L38_04995	COG0302	gtp cyclohydrolase
I6L38_05000	COG0840	transmembrane signaling receptor activity
I6L38_05005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L38_05015	COG0583	DNA-binding transcription factor activity
I6L38_05045	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L38_05055	COG1166	arginine decarboxylase activity
I6L38_05065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L38_05070	COG0583	DNA-binding transcription factor activity
I6L38_05090	COG0814	amino acid
I6L38_05100	COG3681	Belongs to the UPF0597 family
I6L38_05105	COG2964	Protein conserved in bacteria
I6L38_05115	COG1061	Type III restriction enzyme res subunit
I6L38_05125	COG0346	lactoylglutathione lyase activity
I6L38_05135	COG1187	pseudouridine synthase activity
I6L38_05145	COG2807	transmembrane transport
I6L38_05155	COG0583	DNA-binding transcription factor activity
I6L38_05160	COG2271	Major facilitator Superfamily
I6L38_05190	COG2979	Protein of unknown function (DUF533)
I6L38_05200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L38_05210	COG1294	oxidase, subunit
I6L38_05230	COG3220	belongs to the UPF0276 family
I6L38_05245	COG2814	Major facilitator Superfamily
I6L38_05250	COG0656	L-ascorbic acid biosynthetic process
I6L38_05285	COG0583	DNA-binding transcription factor activity
I6L38_05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L38_05305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L38_05310	COG2271	Major facilitator Superfamily
I6L38_05315	COG1349	DNA-binding transcription factor activity
I6L38_05330	COG0584	glycerophosphoryl diester phosphodiesterase
I6L38_05335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L38_05340	COG0287	Prephenate dehydrogenase
I6L38_05340	COG1605	Chorismate mutase
I6L38_05345	COG0583	DNA-binding transcription factor activity
I6L38_05350	COG3085	chromosome segregation
I6L38_05355	COG4574	serine-type endopeptidase inhibitor activity
I6L38_05375	COG1770	oligopeptidase
I6L38_05380	COG4771	TonB-dependent receptor
I6L38_05385	COG3083	sulfuric ester hydrolase activity
I6L38_05390	COG3082	Protein of unknown function (DUF1414)
I6L38_05395	COG3081	Nucleoid-associated protein
I6L38_05405	COG1175	transmembrane transport
I6L38_05410	COG3833	ABC-type maltose transport systems, permease component
I6L38_05415	COG3842	ATPase activity
I6L38_05440	COG0425	Belongs to the sulfur carrier protein TusA family
I6L38_05445	COG4783	chaperone-mediated protein folding
I6L38_05455	COG1393	Belongs to the ArsC family
I6L38_05475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L38_05480	COG2431	L-lysine efflux transmembrane transporter activity
I6L38_05490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_05510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L38_05520	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L38_05525	COG2373	Large extracellular alpha-helical protein
I6L38_05530	COG4953	penicillin-binding protein 1C
I6L38_05540	COG0301	tRNA thio-modification
I6L38_05540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L38_05560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L38_05590	COG1086	Polysaccharide biosynthesis protein
I6L38_05605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L38_05625	COG0483	inositol monophosphate 1-phosphatase activity
I6L38_05635	COG0625	glutathione transferase activity
I6L38_05640	COG2814	Major facilitator Superfamily
I6L38_05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L38_05665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L38_05670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L38_05675	COG0509	glycine decarboxylation via glycine cleavage system
I6L38_05680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L38_05680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L38_05685	COG0641	radical SAM
I6L38_05690	COG3119	arylsulfatase activity
I6L38_05715	COG3634	alkyl hydroperoxide reductase activity
I6L38_05725	COG0517	IMP dehydrogenase activity
I6L38_05730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L38_05735	COG0343	queuine tRNA-ribosyltransferase activity
I6L38_05740	COG1862	Preprotein translocase
I6L38_05745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L38_05750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L38_05765	COG0826	peptidase U32
I6L38_05770	COG0826	peptidase U32
I6L38_05775	COG3154	lipid carrier protein
I6L38_05795	COG1104	cysteine desulfurase activity
I6L38_05800	COG0822	iron-sulfur transferase activity
I6L38_05810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L38_05815	COG0443	Heat shock 70 kDa protein
I6L38_05820	COG0633	Ferredoxin
I6L38_05830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L38_05835	COG0105	UTP biosynthetic process
I6L38_05840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L38_05860	COG0124	histidyl-tRNA synthetase
I6L38_05865	COG2976	Protein conserved in bacteria
I6L38_05870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L38_05875	COG1160	GTP binding
I6L38_05880	COG1645	bacterial-type flagellum-dependent swarming motility
I6L38_05885	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L38_05890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L38_05890	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L38_05895	COG2199	diguanylate cyclase activity
I6L38_05895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L38_05910	COG1007	ATP synthesis coupled electron transport
I6L38_05915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_05925	COG0713	ATP synthesis coupled electron transport
I6L38_05930	COG0839	Belongs to the complex I subunit 6 family
I6L38_05935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_05940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L38_05945	COG1034	ATP synthesis coupled electron transport
I6L38_05960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_05960	COG0649	NAD binding
I6L38_05965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_05970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_05975	COG1360	Flagellar Motor Protein
I6L38_05980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L38_06000	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L38_06020	COG0724	RNA recognition motif
I6L38_06025	COG4989	oxidoreductase activity
I6L38_06050	COG3437	response regulator, receiver
I6L38_06055	COG0583	DNA-binding transcription factor activity
I6L38_06065	COG5001	Diguanylate cyclase
I6L38_06065	COG3300	MHYT domain
I6L38_06070	COG0778	Nitroreductase
I6L38_06090	COG0583	DNA-binding transcription factor activity
I6L38_06100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L38_06105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L38_06110	COG0539	negative regulation of cytoplasmic translation
I6L38_06115	COG0776	regulation of translation
I6L38_06125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L38_06145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L38_06150	COG0602	queuosine metabolic process
I6L38_06155	COG3530	Putative quorum-sensing-regulated virulence factor
I6L38_06160	COG2096	Adenosyltransferase
I6L38_06165	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L38_06170	COG1757	Na H antiporter
I6L38_06175	COG1435	thymidine kinase activity
I6L38_06205	COG3501	Rhs element vgr protein
I6L38_06280	COG3829	transcription factor binding
I6L38_06345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L38_06350	COG1278	Cold shock
I6L38_06355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L38_06360	COG0542	response to heat
I6L38_06365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L38_06370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L38_06375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L38_06380	COG3134	Outer membrane lipoprotein
I6L38_06385	COG3706	GGDEF domain
I6L38_06390	COG0492	ferredoxin-NADP+ reductase activity
I6L38_06400	COG0531	amino acid
I6L38_06400	COG1674	ftsk spoiiie
I6L38_06405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L38_06410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L38_06415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L38_06420	COG1286	toxin biosynthetic process
I6L38_06425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L38_06435	COG4172	Belongs to the ABC transporter superfamily
I6L38_06445	COG4171	peptide transport system, permease
I6L38_06450	COG4168	peptide transport system, permease
I6L38_06460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L38_06465	COG1842	Phage shock protein A
I6L38_06480	COG3106	COG3106 Predicted ATPase
I6L38_06485	COG3768	UPF0283 membrane protein
I6L38_06495	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L38_06515	COG2885	chlorophyll binding
I6L38_06520	COG0861	Integral membrane protein TerC family
I6L38_06535	COG1022	Amp-dependent synthetase and ligase
I6L38_06540	COG0295	cytidine deaminase activity
I6L38_06545	COG1346	cytolysis
I6L38_06550	COG1380	Effector of murein hydrolase LrgA
I6L38_06555	COG3345	alpha-galactosidase
I6L38_06565	COG2925	Exonuclease
I6L38_06570	COG0583	DNA-binding transcription factor activity
I6L38_06580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L38_06585	COG0254	rRNA binding
I6L38_06600	COG1451	nucleotide metabolic process
I6L38_06615	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L38_06625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L38_06625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L38_06630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L38_06655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L38_06670	COG0567	Dehydrogenase, E1 component
I6L38_06675	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L38_06680	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L38_06685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L38_06700	COG2983	Belongs to the UPF0260 family
I6L38_06715	COG3842	ATPase activity
I6L38_06720	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L38_06730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L38_06735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L38_06740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L38_06745	COG1882	Formate acetyltransferase
I6L38_06750	COG2116	formate transmembrane transporter activity
I6L38_06755	COG1944	ATP diphosphatase activity
I6L38_06765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L38_06770	COG0612	Peptidase, M16
I6L38_06775	COG0626	cystathionine gamma-synthase activity
I6L38_06785	COG2910	NAD(P)H-binding
I6L38_06790	COG0583	DNA-binding transcription factor activity
I6L38_06800	COG4977	sequence-specific DNA binding
I6L38_06805	COG4774	siderophore transport
I6L38_06820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L38_06835	COG0516	GMP reductase activity
I6L38_06835	COG0517	IMP dehydrogenase activity
I6L38_06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L38_06845	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L38_06855	COG3033	Beta-eliminating lyase
I6L38_06870	COG4235	cytochrome complex assembly
I6L38_06870	COG3088	subunit of a heme lyase
I6L38_06875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L38_06880	COG1138	Cytochrome C-type biogenesis protein
I6L38_06885	COG3301	Polysulphide reductase, NrfD
I6L38_06890	COG0437	4 iron, 4 sulfur cluster binding
I6L38_06895	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L38_06910	COG0247	lactate metabolic process
I6L38_06915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L38_06920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L38_06925	COG3012	SEC-C Motif Domain Protein
I6L38_06930	COG0840	transmembrane signaling receptor activity
I6L38_06935	COG1846	Transcriptional regulator
I6L38_06935	COG1940	carbohydrate kinase activity
I6L38_06940	COG3290	protein histidine kinase activity
I6L38_06945	COG4565	transcriptional regulatory protein
I6L38_06960	COG3181	Tripartite tricarboxylate transporter family receptor
I6L38_06965	COG1196	nuclear chromosome segregation
I6L38_06965	COG0739	heme binding
I6L38_06965	COG0741	lytic transglycosylase activity
I6L38_06970	COG0569	domain protein
I6L38_06970	COG2985	domain, Protein
I6L38_06980	COG0556	nucleotide-excision repair
I6L38_06990	COG0586	Pfam SNARE associated Golgi protein
I6L38_06995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L38_07000	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L38_07005	COG2186	Transcriptional regulator
I6L38_07010	COG2719	SpoVR family
I6L38_07015	COG2718	Belongs to the UPF0229 family
I6L38_07020	COG2766	serine protein kinase
I6L38_07025	COG0514	ATP-dependent DNA helicase (RecQ)
I6L38_07030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L38_07035	COG0814	amino acid
I6L38_07065	COG0058	SHG alpha-glucan phosphorylase activity
I6L38_07070	COG0471	metal ion transport
I6L38_07075	COG3118	belongs to the thioredoxin family
I6L38_07085	COG1132	(ABC) transporter
I6L38_07090	COG1132	(ABC) transporter
I6L38_07100	COG2501	S4 domain
I6L38_07135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L38_07140	COG2329	Antibiotic biosynthesis monooxygenase
I6L38_07180	COG0513	Belongs to the DEAD box helicase family
I6L38_07185	COG0386	Belongs to the glutathione peroxidase family
I6L38_07195	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L38_07205	COG3148	PFAM DTW domain containing protein
I6L38_07210	COG0730	response to heat
I6L38_07215	COG0583	DNA-binding transcription factor activity
I6L38_07230	COG3593	DNA synthesis involved in DNA repair
I6L38_07285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L38_07290	COG1011	Hydrolase
I6L38_07295	COG1473	amidohydrolase
I6L38_07300	COG0205	6-phosphofructokinase activity
I6L38_07310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L38_07315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L38_07325	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L38_07330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L38_07335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L38_07360	COG0242	peptide deformylase activity
I6L38_07385	COG0384	phenazine biosynthesis protein PhzF
I6L38_07390	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L38_07415	COG0588	phosphoglycerate mutase activity
I6L38_07420	COG3706	GGDEF domain
I6L38_07430	COG2840	Smr protein MutS2
I6L38_07435	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L38_07440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L38_07450	COG0513	Belongs to the DEAD box helicase family
I6L38_07465	COG0814	amino acid
I6L38_07470	COG1609	Transcriptional regulator
I6L38_07475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_07475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_07480	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L38_07485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_07485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L38_07485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L38_07490	COG3313	Fe-S protein
I6L38_07495	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L38_07500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L38_07505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L38_07510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L38_07520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L38_07545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L38_07550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L38_07555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L38_07560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L38_07705	COG4695	Portal protein
I6L38_07785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L38_07800	COG4974	Belongs to the 'phage' integrase family
I6L38_07805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L38_07810	COG0072	phenylalanine-tRNA ligase activity
I6L38_07810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L38_07815	COG0776	regulation of translation
I6L38_07820	COG2205	protein histidine kinase activity
I6L38_07820	COG0784	Response regulator, receiver
I6L38_07845	COG5001	Diguanylate cyclase
I6L38_07845	COG3300	MHYT domain
I6L38_07850	COG1609	Transcriptional regulator
I6L38_07855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L38_07860	COG1879	ABC-type sugar transport system periplasmic component
I6L38_07865	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L38_07870	COG1129	ABC transporter
I6L38_07875	COG1869	D-ribose catabolic process
I6L38_07880	COG0625	glutathione transferase activity
I6L38_07895	COG0037	tRNA processing
I6L38_07900	COG0589	response to stress
I6L38_07905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L38_07930	COG2010	Cytochrome c
I6L38_07945	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L38_07955	COG1956	GAF domain-containing protein
I6L38_07960	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L38_07970	COG0308	aminopeptidase N
I6L38_07980	COG2902	Dehydrogenase
I6L38_07985	COG0167	dihydroorotate dehydrogenase activity
I6L38_07995	COG0116	Belongs to the methyltransferase superfamily
I6L38_07995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L38_08005	COG0488	(ABC) transporter
I6L38_08020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L38_08025	COG1067	ATP-dependent peptidase activity
I6L38_08065	COG4128	Pfam Zonular occludens toxin
I6L38_08090	COG4128	Pfam Zonular occludens toxin
I6L38_08135	COG4128	Pfam Zonular occludens toxin
I6L38_08210	COG4128	Pfam Zonular occludens toxin
I6L38_08235	COG3141	response to X-ray
I6L38_08245	COG4221	oxidoreductase activity
I6L38_08290	COG0372	Belongs to the citrate synthase family
I6L38_08295	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L38_08305	COG2995	paraquat-inducible protein a
I6L38_08310	COG3008	intermembrane lipid transfer
I6L38_08315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L38_08315	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L38_08330	COG0084	hydrolase, TatD family'
I6L38_08335	COG0470	DNA polymerase III
I6L38_08340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L38_08345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L38_08350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L38_08355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L38_08360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L38_08365	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_08375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L38_08380	COG0416	fatty acid biosynthetic process
I6L38_08385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L38_08390	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L38_08400	COG0424	maF-like protein
I6L38_08405	COG0546	phosphoglycolate phosphatase activity
I6L38_08410	COG0564	pseudouridine synthase activity
I6L38_08415	COG1530	ribonuclease E activity
I6L38_08420	COG0306	phosphate transporter
I6L38_08425	COG0717	Belongs to the dCTP deaminase family
I6L38_08430	COG0572	uridine kinase
I6L38_08435	COG0489	protein tyrosine kinase activity
I6L38_08440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L38_08440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L38_08445	COG0625	glutathione transferase activity
I6L38_08450	COG1254	Belongs to the acylphosphatase family
I6L38_08455	COG0840	transmembrane signaling receptor activity
I6L38_08465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L38_08480	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L38_08485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L38_08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L38_08495	COG3437	response regulator, receiver
I6L38_08505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L38_08515	COG1643	Atp-dependent helicase
I6L38_08520	COG0517	IMP dehydrogenase activity
I6L38_08520	COG0617	tRNA 3'-terminal CCA addition
I6L38_08520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L38_08530	COG3314	Sporulation integral membrane protein YlbJ
I6L38_08540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6L38_08545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L38_08555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L38_08560	COG2832	Protein of unknown function (DUF454)
I6L38_08565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L38_08580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L38_08585	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_08590	COG2267	carboxylic ester hydrolase activity
I6L38_08600	COG1214	PFAM Peptidase M22, glycoprotease
I6L38_08605	COG1199	ATP-dependent helicase activity
I6L38_08615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L38_08620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L38_08625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L38_08630	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L38_08630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L38_08635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L38_08640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L38_08645	COG3437	response regulator, receiver
I6L38_08650	COG2199	diguanylate cyclase activity
I6L38_08655	COG2205	protein histidine kinase activity
I6L38_08655	COG0784	Response regulator, receiver
I6L38_08655	COG2198	Histidine kinase
I6L38_08660	COG0107	imidazoleglycerol-phosphate synthase activity
I6L38_08665	COG0140	phosphoribosyl-ATP diphosphatase activity
I6L38_08665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L38_08675	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_08680	COG1288	antiporter activity
I6L38_08690	COG3134	Outer membrane lipoprotein
I6L38_08700	COG2080	2 iron, 2 sulfur cluster binding
I6L38_08705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L38_08710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L38_08715	COG2252	PERMEase
I6L38_08720	COG0402	S-adenosylhomocysteine deaminase activity
I6L38_08725	COG2233	PERMEase
I6L38_08730	COG2080	2 iron, 2 sulfur cluster binding
I6L38_08730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L38_08735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L38_08740	COG0402	S-adenosylhomocysteine deaminase activity
I6L38_08745	COG0493	'glutamate synthase
I6L38_08745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_08750	COG2068	MobA-Related Protein
I6L38_08755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L38_08760	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L38_08760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L38_08765	COG0697	spore germination
I6L38_08770	COG0549	Belongs to the carbamate kinase family
I6L38_08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L38_08785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L38_08790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L38_08795	COG3829	transcription factor binding
I6L38_08825	COG1024	Enoyl-CoA hydratase
I6L38_08825	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L38_08830	COG0183	Belongs to the thiolase family
I6L38_08835	COG0714	Associated with various cellular activities
I6L38_08865	COG1595	DNA-templated transcription, initiation
I6L38_08880	COG2067	long-chain fatty acid transport protein
I6L38_08885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L38_08905	COG3123	guanosine phosphorylase activity
I6L38_08910	COG1760	l-serine dehydratase
I6L38_08915	COG1760	l-serine dehydratase
I6L38_08920	COG2951	lytic endotransglycosylase activity
I6L38_08925	COG3100	YcgL domain-containing protein
I6L38_08930	COG0850	regulation of cytokinetic process
I6L38_08935	COG2894	cell division
I6L38_08940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L38_08945	COG3099	Belongs to the UPF0263 family
I6L38_08950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L38_08990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L38_08995	COG0697	spore germination
I6L38_09000	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L38_09005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L38_09015	COG0307	riboflavin synthase, alpha
I6L38_09025	COG0534	Mate efflux family protein
I6L38_09055	COG0417	DNA replication proofreading
I6L38_09065	COG2199	diguanylate cyclase activity
I6L38_09065	COG2203	Gaf domain
I6L38_09080	COG1560	Kdo2-lipid A biosynthetic process
I6L38_09085	COG1560	Kdo2-lipid A biosynthetic process
I6L38_09100	COG0673	inositol 2-dehydrogenase activity
I6L38_09105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L38_09110	COG0583	DNA-binding transcription factor activity
I6L38_09120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L38_09130	COG5001	Diguanylate cyclase
I6L38_09130	COG3300	MHYT domain
I6L38_09135	COG2723	6-phospho-beta-galactosidase activity
I6L38_09140	COG0583	DNA-binding transcription factor activity
I6L38_09160	COG0667	Aldo Keto reductase
I6L38_09165	COG0583	DNA-binding transcription factor activity
I6L38_09170	COG0702	epimerase
I6L38_09175	COG1073	alpha beta
I6L38_09180	COG1073	alpha beta
I6L38_09195	COG0730	response to heat
I6L38_09205	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_09215	COG1024	Enoyl-CoA hydratase
I6L38_09220	COG1024	Enoyl-CoA hydratase
I6L38_09225	COG1960	acyl-CoA dehydrogenase activity
I6L38_09235	COG1960	acyl-CoA dehydrogenase activity
I6L38_09240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L38_09275	COG1584	GPR1 FUN34 yaaH family protein
I6L38_09280	COG3228	Belongs to the MtfA family
I6L38_09290	COG1115	amino acid carrier protein
I6L38_09295	COG1024	Enoyl-CoA hydratase
I6L38_09310	COG3162	membrane
I6L38_09315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L38_09320	COG0488	(ABC) transporter
I6L38_09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L38_09330	COG0776	regulation of translation
I6L38_09335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L38_09340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L38_09345	COG0740	serine-type endopeptidase activity
I6L38_09350	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L38_09360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L38_09365	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L38_09370	COG1136	(ABC) transporter
I6L38_09375	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L38_09385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L38_09390	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L38_09395	COG4166	transmembrane transport
I6L38_09400	COG0697	spore germination
I6L38_09410	COG2062	phosphohistidine phosphatase, SixA
I6L38_09455	COG0519	Catalyzes the synthesis of GMP from XMP
I6L38_09455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L38_09460	COG0517	IMP dehydrogenase activity
I6L38_09460	COG0516	GMP reductase activity
I6L38_09465	COG3158	transport of potassium into the cell
I6L38_09485	COG0697	spore germination
I6L38_09490	COG1570	exodeoxyribonuclease VII activity
I6L38_09505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L38_09510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L38_09515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L38_09555	COG4771	TonB-dependent receptor
I6L38_09560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L38_09565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L38_09570	COG1120	ATPase activity
I6L38_09575	COG2977	Belongs to the P-Pant transferase superfamily
I6L38_09580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L38_09585	COG0300	oxidoreductase activity
I6L38_09585	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_09585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L38_09585	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_09585	COG3321	synthase
I6L38_09595	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_09600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L38_09605	COG1535	isochorismatase
I6L38_09605	COG3433	isochorismatase activity
I6L38_09610	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L38_09635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L38_09640	COG5001	Diguanylate cyclase
I6L38_09640	COG3300	MHYT domain
I6L38_09655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L38_09660	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L38_09665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L38_09670	COG0563	adenylate kinase activity
I6L38_09675	COG0326	Molecular chaperone. Has ATPase activity
I6L38_09680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L38_09705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_09720	COG3158	transport of potassium into the cell
I6L38_09725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L38_09730	COG0651	ATP synthesis coupled electron transport
I6L38_09735	COG0650	Formate hydrogenlyase subunit 4
I6L38_09740	COG3261	NADH dehydrogenase
I6L38_09740	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L38_09745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_09750	COG3260	NADH ubiquinone oxidoreductase 20
I6L38_09760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L38_09770	COG1921	L-seryl-tRNASec selenium transferase activity
I6L38_09780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L38_09785	COG0298	carbon dioxide binding
I6L38_09795	COG0309	Hydrogenase expression formation protein (HypE)
I6L38_09800	COG0375	protein maturation
I6L38_09805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L38_09810	COG1124	(ABC) transporter
I6L38_09815	COG0444	Belongs to the ABC transporter superfamily
I6L38_09820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L38_09835	COG1773	rubredoxin
I6L38_09840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L38_09845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L38_09850	COG5557	Pfam Polysulphide reductase, NrfD
I6L38_09855	COG0437	4 iron, 4 sulfur cluster binding
I6L38_09860	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L38_09865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L38_09885	COG0659	secondary active sulfate transmembrane transporter activity
I6L38_09925	COG0672	)-iron permease
I6L38_09945	COG2814	Major facilitator Superfamily
I6L38_09965	COG1136	(ABC) transporter
I6L38_09970	COG0577	efflux transmembrane transporter activity
I6L38_10000	COG1139	Iron-sulfur cluster binding protein
I6L38_10005	COG0247	lactate metabolic process
I6L38_10010	COG1620	l-lactate permease
I6L38_10015	COG0583	DNA-binding transcription factor activity
I6L38_10020	COG0596	Alpha beta hydrolase
I6L38_10040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L38_10045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L38_10045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L38_10050	COG0527	aspartate kinase activity
I6L38_10060	COG1368	sulfuric ester hydrolase activity
I6L38_10065	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L38_10075	COG0393	Putative heavy-metal-binding
I6L38_10095	COG1252	NADH dehydrogenase
I6L38_10100	COG3150	esterase
I6L38_10105	COG2233	PERMEase
I6L38_10120	COG2354	Protein conserved in bacteria
I6L38_10135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L38_10140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L38_10175	COG0537	adenosine 5'-monophosphoramidase activity
I6L38_10190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L38_10205	COG1301	dicarboxylic acid transport
I6L38_10215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L38_10220	COG0861	Integral membrane protein TerC family
I6L38_10230	COG0444	Belongs to the ABC transporter superfamily
I6L38_10235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L38_10240	COG0601	transmembrane transport
I6L38_10250	COG2095	MarC family integral membrane protein
I6L38_10260	COG1012	belongs to the aldehyde dehydrogenase family
I6L38_10260	COG1454	alcohol dehydrogenase
I6L38_10265	COG2199	diguanylate cyclase activity
I6L38_10265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L38_10270	COG3275	phosphorelay sensor kinase activity
I6L38_10275	COG3279	Response regulator of the LytR AlgR family
I6L38_10280	COG1966	Carbon starvation protein
I6L38_10290	COG1566	PFAM secretion protein HlyD family protein
I6L38_10295	COG1061	Type III restriction enzyme res subunit
I6L38_10300	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L38_10305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L38_10315	COG0436	Aminotransferase
I6L38_10320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L38_10320	COG3264	Mechanosensitive ion channel
I6L38_10325	COG1288	antiporter activity
I6L38_10330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L38_10340	COG0697	spore germination
I6L38_10345	COG4657	Part of a membrane complex involved in electron transport
I6L38_10350	COG2878	Part of a membrane complex involved in electron transport
I6L38_10360	COG4658	electron transport chain
I6L38_10365	COG4659	FMN binding
I6L38_10370	COG4660	Part of a membrane complex involved in electron transport
I6L38_10375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L38_10380	COG0346	lactoylglutathione lyase activity
I6L38_10395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L38_10400	COG2056	Na+-H+ antiporter family
I6L38_10410	COG2050	protein possibly involved in aromatic compounds catabolism
I6L38_10420	COG0277	FAD linked oxidase domain protein
I6L38_10420	COG0247	lactate metabolic process
I6L38_10430	COG1253	flavin adenine dinucleotide binding
I6L38_10435	COG1902	pentaerythritol trinitrate reductase activity
I6L38_10440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L38_10445	COG0647	UMP catabolic process
I6L38_10450	COG4651	solute:proton antiporter activity
I6L38_10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L38_10460	COG0367	asparagine synthase
I6L38_10470	COG0625	glutathione transferase activity
I6L38_10480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L38_10495	COG0564	pseudouridine synthase activity
I6L38_10500	COG5001	Diguanylate cyclase
I6L38_10505	COG0840	transmembrane signaling receptor activity
I6L38_10515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6L38_10515	COG0392	lysyltransferase activity
I6L38_10520	COG2194	sulfuric ester hydrolase activity
I6L38_10540	COG0670	Belongs to the BI1 family
I6L38_10545	COG1289	transmembrane transporter activity
I6L38_10550	COG2920	part of a sulfur-relay system
I6L38_10555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L38_10560	COG0285	dihydrofolate synthase activity
I6L38_10565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L38_10570	COG0101	tRNA pseudouridine synthase activity
I6L38_10580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L38_10585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L38_10590	COG0671	phosphoesterase, PA-phosphatase related
I6L38_10595	COG1464	Belongs to the NlpA lipoprotein family
I6L38_10635	COG0574	Belongs to the PEP-utilizing enzyme family
I6L38_10635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L38_10640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L38_10705	COG1242	4 iron, 4 sulfur cluster binding
I6L38_10710	COG0067	glutamate synthase
I6L38_10710	COG0069	glutamate synthase activity
I6L38_10710	COG0070	glutamate synthase
I6L38_10715	COG0493	'glutamate synthase
I6L38_10730	COG0789	Transcriptional regulator
I6L38_10745	COG4104	PAAR repeat-containing protein
I6L38_10755	COG0513	Belongs to the DEAD box helicase family
I6L38_10760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L38_10810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L38_10815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L38_10820	COG0505	Belongs to the CarA family
I6L38_10825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L38_10835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L38_10840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L38_10845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L38_10850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L38_10855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L38_10860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L38_10870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_10870	COG2205	protein histidine kinase activity
I6L38_10910	COG0023	Translation Initiation Factor
I6L38_10915	COG2119	membrane
I6L38_10945	COG2199	diguanylate cyclase activity
I6L38_10945	COG2203	Gaf domain
I6L38_10955	COG1204	response to ionizing radiation
I6L38_10965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L38_10975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L38_10980	COG3301	Polysulphide reductase, NrfD
I6L38_10985	COG0437	4 iron, 4 sulfur cluster binding
I6L38_10990	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L38_11035	COG4974	Belongs to the 'phage' integrase family
I6L38_11050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L38_11135	COG4695	Portal protein
I6L38_11310	COG0322	excinuclease ABC activity
I6L38_11315	COG2197	response regulator
I6L38_11320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L38_11325	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L38_11330	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L38_11340	COG0658	competence protein
I6L38_11340	COG2333	competence protein COMEC
I6L38_11355	COG0433	COG0433 Predicted ATPase
I6L38_11360	COG1448	Aminotransferase
I6L38_11375	COG1199	ATP-dependent helicase activity
I6L38_11385	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L38_11390	COG0477	Major facilitator Superfamily
I6L38_11395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L38_11420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L38_11435	COG2271	Major facilitator Superfamily
I6L38_11440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_11445	COG0765	amino acid transport
I6L38_11470	COG0531	amino acid
I6L38_11485	COG1253	flavin adenine dinucleotide binding
I6L38_11490	COG0704	Plays a role in the regulation of phosphate uptake
I6L38_11495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L38_11500	COG0581	inorganic phosphate transmembrane transporter activity
I6L38_11505	COG0573	inorganic phosphate transmembrane transporter activity
I6L38_11510	COG0590	tRNA wobble adenosine to inosine editing
I6L38_11525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L38_11545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L38_11550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L38_11555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L38_11560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L38_11585	COG2716	regulation of RNA biosynthetic process
I6L38_11590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L38_11600	COG2239	Acts as a magnesium transporter
I6L38_11610	COG1256	bacterial-type flagellum assembly
I6L38_11615	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L38_11615	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L38_11620	COG1706	bacterial-type flagellum-dependent cell motility
I6L38_11625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L38_11635	COG4787	bacterial-type flagellum-dependent cell motility
I6L38_11655	COG1815	bacterial-type flagellum-dependent cell motility
I6L38_11660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L38_11665	COG0784	Response regulator, receiver
I6L38_11665	COG0835	chemotaxis
I6L38_11670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L38_11685	COG0622	Phosphoesterase
I6L38_11690	COG4166	transmembrane transport
I6L38_11715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L38_11720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L38_11725	COG1882	Formate acetyltransferase
I6L38_11730	COG1349	DNA-binding transcription factor activity
I6L38_11735	COG0697	spore germination
I6L38_11765	COG1278	Cold shock
I6L38_11805	COG3132	Protein of unknown function, DUF480
I6L38_11815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L38_11835	COG0489	protein tyrosine kinase activity
I6L38_11835	COG3206	protein involved in exopolysaccharide biosynthesis
I6L38_11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L38_11845	COG1596	polysaccharide export
I6L38_11855	COG0297	glycogen (starch) synthase activity
I6L38_11860	COG3306	glycosyltransferase involved in LPS biosynthesis
I6L38_11875	COG1216	Glycosyl transferase, family 2
I6L38_11910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L38_11925	COG1051	belongs to the nudix hydrolase family
I6L38_11955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L38_11960	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6L38_11965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L38_11980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L38_11985	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L38_12000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L38_12005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_12010	COG1309	transcriptional regulator
I6L38_12025	COG1946	Acyl-CoA thioesterase
I6L38_12035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L38_12045	COG0009	L-threonylcarbamoyladenylate synthase
I6L38_12055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L38_12060	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L38_12060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L38_12065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L38_12070	COG0135	phosphoribosylanthranilate isomerase activity
I6L38_12070	COG0134	indole-3-glycerol-phosphate synthase activity
I6L38_12075	COG0133	tryptophan synthase activity
I6L38_12080	COG0159	tryptophan synthase activity
I6L38_12090	COG1988	membrane-bound metal-dependent
I6L38_12095	COG1396	sequence-specific DNA binding
I6L38_12100	COG3550	peptidyl-serine autophosphorylation
I6L38_12120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L38_12130	COG4521	taurine ABC transporter
I6L38_12135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L38_12140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L38_12145	COG2175	clavaminate synthase activity
I6L38_12155	COG2814	Major facilitator Superfamily
I6L38_12160	COG0109	protoheme IX farnesyltransferase activity
I6L38_12165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L38_12170	COG1845	cytochrome c oxidase, subunit III
I6L38_12175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L38_12180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L38_12185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6L38_12230	COG2211	Major facilitator Superfamily
I6L38_12235	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L38_12250	COG0708	Exodeoxyribonuclease III
I6L38_12265	COG2067	long-chain fatty acid transport protein
I6L38_12275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_12280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L38_12295	COG0095	Lipoate-protein ligase
I6L38_12325	COG0640	Transcriptional regulator
I6L38_12340	COG1285	pathogenesis
I6L38_12370	COG0484	heat shock protein binding
I6L38_12375	COG0443	Heat shock 70 kDa protein
I6L38_12380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L38_12385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L38_12390	COG0497	DNA recombination
I6L38_12395	COG1227	inorganic diphosphatase activity
I6L38_12405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_12410	COG1136	(ABC) transporter
I6L38_12410	COG0577	efflux transmembrane transporter activity
I6L38_12420	COG2375	cellular response to nickel ion
I6L38_12425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L38_12445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L38_12450	COG1396	sequence-specific DNA binding
I6L38_12450	COG1917	Cupin 2, conserved barrel domain protein
I6L38_12465	COG0531	amino acid
I6L38_12475	COG0531	amino acid
I6L38_12485	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L38_12495	COG3384	dioxygenase
I6L38_12500	COG0784	Response regulator, receiver
I6L38_12500	COG2205	protein histidine kinase activity
I6L38_12500	COG5002	protein histidine kinase activity
I6L38_12505	COG2203	Gaf domain
I6L38_12505	COG3706	GGDEF domain
I6L38_12505	COG4251	negative regulation of phosphorylation
I6L38_12505	COG5001	Diguanylate cyclase
I6L38_12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_12510	COG2205	protein histidine kinase activity
I6L38_12525	COG0813	purine-nucleoside phosphorylase activity
I6L38_12555	COG0488	(ABC) transporter
I6L38_12570	COG4319	ketosteroid isomerase
I6L38_12575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L38_12580	COG0083	homoserine kinase activity
I6L38_12590	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L38_12595	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L38_12610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L38_12620	COG0745	RESPONSE REGULATOR receiver
I6L38_12635	COG4988	ABC transporter
I6L38_12640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L38_12660	COG1720	tRNA m6t6A37 methyltransferase activity
I6L38_12665	COG3437	response regulator, receiver
I6L38_12665	COG2770	Histidine kinase
I6L38_12680	COG0542	response to heat
I6L38_12685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L38_12690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_12695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L38_12700	COG2190	(PTS) system
I6L38_12710	COG3038	cytochrome b561
I6L38_12725	COG0420	3'-5' exonuclease activity
I6L38_12735	COG2974	May be involved in recombination
I6L38_12745	COG4651	solute:proton antiporter activity
I6L38_12745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L38_12760	COG0469	pyruvate kinase activity
I6L38_12765	COG1196	nuclear chromosome segregation
I6L38_12765	COG3264	Mechanosensitive ion channel
I6L38_12775	COG2706	6-phosphogluconolactonase activity
I6L38_12790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_12810	COG0281	malic enzyme
I6L38_12820	COG0437	4 iron, 4 sulfur cluster binding
I6L38_12825	COG3383	formate dehydrogenase (NAD+) activity
I6L38_12825	COG3383	formate dehydrogenase (NAD+) activity
I6L38_12860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L38_12865	COG1910	domain protein
I6L38_12870	COG3852	Histidine kinase
I6L38_12885	COG4662	Binding-protein-dependent transport system inner membrane component
I6L38_12895	COG0746	molybdenum cofactor guanylyltransferase activity
I6L38_12900	COG0303	'Molybdopterin
I6L38_12905	COG1289	transmembrane transporter activity
I6L38_12935	COG3220	belongs to the UPF0276 family
I6L38_12975	COG2205	protein histidine kinase activity
I6L38_12975	COG0784	Response regulator, receiver
I6L38_12980	COG4166	transmembrane transport
I6L38_12985	COG0601	transmembrane transport
I6L38_12990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L38_12995	COG0444	Belongs to the ABC transporter superfamily
I6L38_13000	COG4608	Belongs to the ABC transporter superfamily
I6L38_13010	COG2971	BadF BadG BcrA BcrD
I6L38_13020	COG0840	transmembrane signaling receptor activity
I6L38_13040	COG3724	N-succinylarginine dihydrolase activity
I6L38_13045	COG0616	signal peptide processing
I6L38_13050	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_13055	COG0583	DNA-binding transcription factor activity
I6L38_13065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L38_13075	COG0583	DNA-binding transcription factor activity
I6L38_13080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L38_13085	COG1881	PFAM PEBP family protein
I6L38_13095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L38_13095	COG3408	Glycogen debranching enzyme
I6L38_13100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L38_13105	COG0739	heme binding
I6L38_13110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L38_13130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L38_13140	COG3091	SprT-like family
I6L38_13150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L38_13155	COG0189	ligase activity
I6L38_13165	COG1678	Uncharacterized ACR, COG1678
I6L38_13170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L38_13175	COG3104	oligopeptide transport
I6L38_13185	COG0714	Associated with various cellular activities
I6L38_13200	COG1115	amino acid carrier protein
I6L38_13205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L38_13220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L38_13230	COG1301	dicarboxylic acid transport
I6L38_13235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L38_13240	COG2912	Transglutaminase-like superfamily
I6L38_13250	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L38_13255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L38_13260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L38_13265	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L38_13270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L38_13280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L38_13285	COG0737	Belongs to the 5'-nucleotidase family
I6L38_13290	COG0193	aminoacyl-tRNA hydrolase activity
I6L38_13295	COG0012	GTP binding
I6L38_13340	COG0471	metal ion transport
I6L38_13340	COG0490	domain, Protein
I6L38_13350	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L38_13360	COG3097	Belongs to the UPF0267 family
I6L38_13370	COG0366	Alpha amylase catalytic
I6L38_13380	COG0488	(ABC) transporter
I6L38_13410	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L38_13410	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L38_13410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L38_13410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L38_13420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L38_13430	COG1012	belongs to the aldehyde dehydrogenase family
I6L38_13440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L38_13455	COG0180	Tryptophanyl-tRNA synthetase
I6L38_13465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L38_13470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L38_13480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L38_13485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L38_13515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L38_13520	COG0583	DNA-binding transcription factor activity
I6L38_13540	COG0583	DNA-binding transcription factor activity
I6L38_13555	COG0739	heme binding
I6L38_13565	COG1511	domain protein
I6L38_13565	COG3264	Mechanosensitive ion channel
I6L38_13570	COG0584	glycerophosphoryl diester phosphodiesterase
I6L38_13580	COG1053	succinate dehydrogenase
I6L38_13585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L38_13590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L38_13600	COG3366	ferrous iron transmembrane transporter activity
I6L38_13605	COG0700	Nucleoside recognition
I6L38_13610	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L38_13620	COG3214	Protein conserved in bacteria
I6L38_13660	COG0642	Histidine kinase
I6L38_13670	COG0516	GMP reductase activity
I6L38_13680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L38_13685	COG3647	Membrane
I6L38_13695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L38_13715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L38_13730	COG3706	GGDEF domain
I6L38_13745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L38_13750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L38_13755	COG1702	phosphate starvation-inducible protein PhoH
I6L38_13760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L38_13765	COG4535	Mg2 and Co2 transporter CorC
I6L38_13770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L38_13775	COG2888	peptidyl-tyrosine sulfation
I6L38_13780	COG0495	leucyl-tRNA aminoacylation
I6L38_13795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L38_13800	COG0799	negative regulation of ribosome biogenesis
I6L38_13805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L38_13810	COG0768	penicillin binding
I6L38_13815	COG0772	Belongs to the SEDS family
I6L38_13820	COG2951	lytic endotransglycosylase activity
I6L38_13825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L38_13830	COG1686	Belongs to the peptidase S11 family
I6L38_13835	COG2921	Belongs to the UPF0250 family
I6L38_13840	COG0321	lipoyl(octanoyl) transferase activity
I6L38_13845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L38_13850	COG3545	Serine hydrolase
I6L38_13870	COG0789	Transcriptional regulator
I6L38_13875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L38_13885	COG1970	mechanosensitive ion channel activity
I6L38_13895	COG4974	Belongs to the 'phage' integrase family
I6L38_13905	COG0312	modulator of DNA gyrase
I6L38_13910	COG0312	modulator of DNA gyrase
I6L38_13955	COG0114	fumarate hydratase activity
I6L38_13965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L38_13970	COG3706	GGDEF domain
I6L38_13975	COG2211	Major facilitator Superfamily
I6L38_13980	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L38_13985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L38_13990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L38_13995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L38_14000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L38_14005	COG0195	Participates in both transcription termination and antitermination
I6L38_14010	COG0779	Required for maturation of 30S ribosomal subunits
I6L38_14025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L38_14030	COG0149	triose-phosphate isomerase activity
I6L38_14035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L38_14040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L38_14050	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L38_14055	COG1534	Rna-binding protein
I6L38_14070	COG1360	Flagellar Motor Protein
I6L38_14075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L38_14080	COG1722	exodeoxyribonuclease VII activity
I6L38_14085	COG0142	geranyltranstransferase activity
I6L38_14090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L38_14095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L38_14100	COG0601	transmembrane transport
I6L38_14110	COG4172	Belongs to the ABC transporter superfamily
I6L38_14115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L38_14120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L38_14125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L38_14130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L38_14145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L38_14145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L38_14150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L38_14165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L38_14175	COG2205	protein histidine kinase activity
I6L38_14175	COG2198	Histidine kinase
I6L38_14175	COG0784	Response regulator, receiver
I6L38_14180	COG1879	ABC-type sugar transport system periplasmic component
I6L38_14190	COG0745	RESPONSE REGULATOR receiver
I6L38_14195	COG3005	denitrification pathway
I6L38_14205	COG3381	protein complex oligomerization
I6L38_14225	COG5001	Diguanylate cyclase
I6L38_14225	COG3300	MHYT domain
I6L38_14235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L38_14240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L38_14245	COG0511	ligase activity, forming carbon-carbon bonds
I6L38_14250	COG0439	Biotin carboxylase
I6L38_14255	COG3924	membrane
I6L38_14260	COG4145	pantothenate transmembrane transporter activity
I6L38_14265	COG1263	PTS System
I6L38_14265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_14265	COG2190	(PTS) system
I6L38_14270	COG0583	DNA-binding transcription factor activity
I6L38_14275	COG0604	alcohol dehydrogenase
I6L38_14280	COG2264	protein methyltransferase activity
I6L38_14295	COG0778	Nitroreductase
I6L38_14300	COG1902	pentaerythritol trinitrate reductase activity
I6L38_14300	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L38_14305	COG0616	signal peptide processing
I6L38_14325	COG3139	Protein of unknown function (DUF1315)
I6L38_14330	COG0252	asparaginase activity
I6L38_14335	COG0786	glutamate:sodium symporter activity
I6L38_14350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L38_14355	COG0384	phenazine biosynthesis protein PhzF
I6L38_14360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L38_14365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L38_14370	COG0175	sulfate reduction
I6L38_14375	COG2113	Glycine betaine
I6L38_14380	COG4176	ABC-type proline glycine betaine transport system permease component
I6L38_14385	COG4175	Glycine betaine
I6L38_14395	COG3610	response to peptide
I6L38_14400	COG2966	Psort location CytoplasmicMembrane, score
I6L38_14410	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L38_14420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L38_14425	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_14435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L38_14465	COG2986	histidine ammonia-lyase
I6L38_14475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L38_14490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L38_14495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L38_14530	COG1858	cytochrome C peroxidase
I6L38_14540	COG2313	pseudouridylate synthase activity
I6L38_14545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L38_14570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L38_14585	COG1073	alpha beta
I6L38_14590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L38_14595	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L38_14600	COG4608	Belongs to the ABC transporter superfamily
I6L38_14605	COG0444	Belongs to the ABC transporter superfamily
I6L38_14615	COG4239	(ABC) transporter, permease
I6L38_14620	COG4174	ABC transporter (Permease)
I6L38_14635	COG0811	peptide transport
I6L38_14640	COG0811	peptide transport
I6L38_14645	COG0848	biopolymer transport protein
I6L38_14695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L38_14700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L38_14705	COG0840	transmembrane signaling receptor activity
I6L38_14715	COG1278	Cold shock
I6L38_14755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L38_14760	COG1162	GTPase activity
I6L38_14765	COG0688	phosphatidylethanolamine metabolic process
I6L38_14770	COG4628	conserved protein (DUF2132)
I6L38_14790	COG5001	Diguanylate cyclase
I6L38_14790	COG3300	MHYT domain
I6L38_14795	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L38_14820	COG1132	(ABC) transporter
I6L38_14830	COG1404	Belongs to the peptidase S8 family
I6L38_14835	COG2897	thiosulfate sulfurtransferase activity
I6L38_14840	COG2066	Belongs to the glutaminase family
I6L38_14845	COG3171	Protein conserved in bacteria
I6L38_14850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L38_14855	COG2234	aminopeptidase activity
I6L38_14855	COG4935	Belongs to the peptidase S8 family
I6L38_14860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L38_14865	COG2200	EAL domain
I6L38_14870	COG1090	epimerase
I6L38_14875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L38_14880	COG4181	ATPase activity
I6L38_14885	COG2755	lipolytic protein G-D-S-L family
I6L38_14890	COG0835	chemotaxis
I6L38_14890	COG0784	Response regulator, receiver
I6L38_14905	COG5001	Diguanylate cyclase
I6L38_14905	COG3300	MHYT domain
I6L38_14915	COG0459	protein refolding
I6L38_14920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L38_14925	COG0534	Mate efflux family protein
I6L38_14930	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L38_14935	COG1027	Aspartate ammonia-lyase
I6L38_14940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L38_14950	COG0477	Major facilitator Superfamily
I6L38_14960	COG3227	Zinc metalloprotease (Elastase)
I6L38_14965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L38_14970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L38_14980	COG0673	inositol 2-dehydrogenase activity
I6L38_14990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L38_14995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L38_15000	COG3036	rescue of stalled ribosome
I6L38_15015	COG0138	bifunctional purine biosynthesis protein purh
I6L38_15040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L38_15045	COG0358	DNA primase activity
I6L38_15050	COG1610	YqeY-like protein
I6L38_15055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L38_15060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L38_15075	COG1238	metal cluster binding
I6L38_15080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L38_15085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L38_15090	COG0585	pseudouridine synthase activity
I6L38_15100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L38_15105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L38_15110	COG0148	phosphopyruvate hydratase activity
I6L38_15115	COG0504	CTP synthase activity
I6L38_15120	COG3956	TIGRFAM MazG family protein
I6L38_15125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L38_15130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L38_15140	COG4807	Protein conserved in bacteria
I6L38_15145	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L38_15150	COG1349	DNA-binding transcription factor activity
I6L38_15160	COG2222	sugar isomerase
I6L38_15165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_15175	COG3716	PTS system mannose fructose sorbose family IID component
I6L38_15180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_15185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L38_15195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L38_15200	COG1381	Involved in DNA repair and RecF pathway recombination
I6L38_15210	COG0571	ribonuclease III activity
I6L38_15215	COG0681	Belongs to the peptidase S26 family
I6L38_15220	COG0481	GTPase activity
I6L38_15235	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L38_15240	COG1595	DNA-templated transcription, initiation
I6L38_15245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L38_15255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L38_15260	COG0354	folic acid binding
I6L38_15280	COG1324	tolerance protein
I6L38_15305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L38_15315	COG0126	phosphoglycerate kinase activity
I6L38_15320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L38_15325	COG1940	carbohydrate kinase activity
I6L38_15330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L38_15335	COG2816	NAD+ diphosphatase activity
I6L38_15345	COG4991	sh3 domain protein
I6L38_15350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L38_15365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L38_15380	COG2982	Protein involved in outer membrane biogenesis
I6L38_15385	COG1505	serine-type exopeptidase activity
I6L38_15390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L38_15395	COG0765	amino acid transport
I6L38_15400	COG0765	amino acid transport
I6L38_15405	COG1126	abc transporter atp-binding protein
I6L38_15410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_15415	COG0577	efflux transmembrane transporter activity
I6L38_15415	COG1136	(ABC) transporter
I6L38_15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_15425	COG0745	RESPONSE REGULATOR receiver
I6L38_15430	COG2205	protein histidine kinase activity
I6L38_15465	COG2070	2-Nitropropane dioxygenase
I6L38_15490	COG1858	cytochrome C peroxidase
I6L38_15495	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L38_15515	COG0513	Belongs to the DEAD box helicase family
I6L38_15525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L38_15530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L38_15550	COG0154	amidase activity
I6L38_15555	COG2957	Belongs to the agmatine deiminase family
I6L38_15565	COG2852	Protein conserved in bacteria
I6L38_15575	COG1902	pentaerythritol trinitrate reductase activity
I6L38_15585	COG0456	acetyltransferase
I6L38_15605	COG5001	Diguanylate cyclase
I6L38_15625	COG0714	Associated with various cellular activities
I6L38_15635	COG0456	acetyltransferase
I6L38_15645	COG1022	Amp-dependent synthetase and ligase
I6L38_15650	COG2918	glutathione biosynthetic process
I6L38_15655	COG0612	Peptidase, M16
I6L38_15660	COG1238	metal cluster binding
I6L38_15690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L38_15695	COG0359	binds to the 23S rRNA
I6L38_15700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L38_15705	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L38_15710	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L38_15720	COG0583	DNA-binding transcription factor activity
I6L38_15730	COG2814	Major facilitator Superfamily
I6L38_15750	COG0697	spore germination
I6L38_15755	COG2153	protein acetylation
I6L38_15765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L38_15780	COG0384	phenazine biosynthesis protein PhzF
I6L38_15795	COG0557	exoribonuclease II activity
I6L38_15800	COG3706	GGDEF domain
I6L38_15805	COG1854	S-ribosylhomocysteine lyase activity
I6L38_15820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L38_15820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L38_15880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L38_15885	COG1047	Peptidyl-prolyl cis-trans
I6L38_15890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L38_15895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L38_15900	COG0196	riboflavin kinase activity
I6L38_15905	COG0728	peptidoglycan biosynthetic process
I6L38_15910	COG0268	Binds directly to 16S ribosomal RNA
I6L38_15915	COG0640	Transcriptional regulator
I6L38_15920	COG0583	DNA-binding transcription factor activity
I6L38_15930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L38_15935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L38_15940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L38_15950	COG1051	belongs to the nudix hydrolase family
I6L38_15955	COG3066	DNA modification
I6L38_15965	COG0335	large ribosomal subunit rRNA binding
I6L38_15970	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L38_15975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L38_15980	COG0228	four-way junction DNA binding
I6L38_15985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L38_15990	COG4137	Cytochrome C assembly protein
I6L38_15995	COG4536	flavin adenine dinucleotide binding
I6L38_16000	COG1959	2 iron, 2 sulfur cluster binding
I6L38_16005	COG1017	nitric oxide dioxygenase activity
I6L38_16005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L38_16010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L38_16015	COG0039	L-malate dehydrogenase activity
I6L38_16020	COG4160	amino acid transport
I6L38_16025	COG4215	(ABC) transporter
I6L38_16030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_16035	COG1126	abc transporter atp-binding protein
I6L38_16040	COG1438	arginine binding
I6L38_16045	COG2837	iron assimilation
I6L38_16050	COG3842	ATPase activity
I6L38_16060	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L38_16065	COG0347	Belongs to the P(II) protein family
I6L38_16080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L38_16085	COG0583	DNA-binding transcription factor activity
I6L38_16100	COG1929	Belongs to the glycerate kinase type-1 family
I6L38_16105	COG2610	gluconate transmembrane transporter activity
I6L38_16110	COG3835	regulator
I6L38_16115	COG3112	Uncharacterised protein family (UPF0231)
I6L38_16145	COG0513	Belongs to the DEAD box helicase family
I6L38_16185	COG1448	Aminotransferase
I6L38_16200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L38_16205	COG1328	CTP reductase activity
I6L38_16225	COG0793	Belongs to the peptidase S41A family
I6L38_16225	COG4946	Tricorn protease homolog
I6L38_16260	COG3397	chitin binding
I6L38_16265	COG0583	DNA-binding transcription factor activity
I6L38_16270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L38_16275	COG4208	sulfate ABC transporter
I6L38_16280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L38_16290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L38_16295	COG3174	membrane
I6L38_16300	COG0110	maltose O-acetyltransferase activity
I6L38_16325	COG0165	Argininosuccinate lyase
I6L38_16330	COG0137	argininosuccinate synthase activity
I6L38_16340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L38_16345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L38_16355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L38_16360	COG0527	aspartate kinase activity
I6L38_16360	COG0460	homoserine dehydrogenase
I6L38_16365	COG0626	cystathionine gamma-synthase activity
I6L38_16375	COG3708	Transcriptional regulator
I6L38_16375	COG2207	Transcriptional regulator
I6L38_16380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L38_16385	COG0814	amino acid
I6L38_16390	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L38_16395	COG0494	nUDIX hydrolase
I6L38_16400	COG1011	Hydrolase
I6L38_16405	COG1902	pentaerythritol trinitrate reductase activity
I6L38_16415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L38_16430	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L38_16440	COG3156	type II secretion system protein K
I6L38_16445	COG4795	General secretion pathway protein
I6L38_16450	COG2165	general secretion pathway protein
I6L38_16460	COG2165	general secretion pathway protein
I6L38_16465	COG1459	type II secretion system
I6L38_16470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L38_16480	COG3031	protein transport across the cell outer membrane
I6L38_16490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L38_16495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L38_16520	COG0456	acetyltransferase
I6L38_16525	COG3133	Outer membrane lipoprotein
I6L38_16540	COG2771	luxR family
I6L38_16545	COG3916	Acyl-homoserine-lactone synthase
I6L38_16555	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L38_16560	COG1309	transcriptional regulator
I6L38_16570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_16570	COG2213	PTS system mannitol-specific
I6L38_16575	COG0246	Mannitol dehydrogenase
I6L38_16580	COG3722	fumarate hydratase activity
I6L38_16585	COG3263	regulation of cellular component size
I6L38_16610	COG1671	Belongs to the UPF0178 family
I6L38_16625	COG1988	membrane-bound metal-dependent
I6L38_16630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L38_16635	COG0513	Belongs to the DEAD box helicase family
I6L38_16670	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L38_16675	COG1169	isochorismate synthase
I6L38_16680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L38_16685	COG0596	Alpha beta hydrolase
I6L38_16690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L38_16695	COG1441	menaquinone biosynthetic process
I6L38_16700	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_16720	COG3121	Chaperone
I6L38_16725	COG3188	usher protein
I6L38_16735	COG3539	Fimbrial protein
I6L38_16745	COG3291	Pkd domain containing protein
I6L38_16750	COG2949	membrane
I6L38_16755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L38_16765	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L38_16770	COG5380	lipid catabolic process
I6L38_16795	COG2873	o-acetylhomoserine
I6L38_16805	COG1979	alcohol dehydrogenase
I6L38_16820	COG4221	oxidoreductase activity
I6L38_16840	COG1285	pathogenesis
I6L38_16860	COG1368	sulfuric ester hydrolase activity
I6L38_16865	COG1522	sequence-specific DNA binding
I6L38_16875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L38_16880	COG1418	mRNA catabolic process
I6L38_16885	COG1546	Belongs to the CinA family
I6L38_16885	COG1058	Belongs to the CinA family
I6L38_16895	COG0842	Transport permease protein
I6L38_16895	COG1129	ABC transporter
I6L38_16910	COG0561	phosphatase activity
I6L38_16915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L38_16935	COG1011	Hydrolase
I6L38_16950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L38_16955	COG0019	diaminopimelate decarboxylase activity
I6L38_16965	COG1965	Belongs to the frataxin family
I6L38_16970	COG0400	carboxylic ester hydrolase activity
I6L38_16975	COG3072	Adenylate cyclase
I6L38_16980	COG0181	hydroxymethylbilane synthase activity
I6L38_16990	COG2959	enzyme of heme biosynthesis
I6L38_17005	COG1494	fructose-1,6-bisphosphatase
I6L38_17040	COG0456	acetyltransferase
I6L38_17045	COG1733	regulation of RNA biosynthetic process
I6L38_17065	COG3932	Exopolysaccharide synthesis, ExoD
I6L38_17070	COG0814	amino acid
I6L38_17090	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6L38_17105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L38_17110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
I6L38_17120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L38_17125	COG2022	thiamine diphosphate biosynthetic process
I6L38_17135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L38_17140	COG0352	thiamine-phosphate diphosphorylase activity
I6L38_17145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L38_17165	COG0745	RESPONSE REGULATOR receiver
I6L38_17170	COG0642	Histidine kinase
I6L38_17175	COG0189	ligase activity
I6L38_17200	COG1639	'signal transduction protein
I6L38_17210	COG2321	neutral zinc metallopeptidase
I6L38_17215	COG3700	Belongs to the class B bacterial acid phosphatase family
I6L38_17245	COG0784	Response regulator, receiver
I6L38_17245	COG2205	protein histidine kinase activity
I6L38_17245	COG5002	protein histidine kinase activity
I6L38_17250	COG3437	response regulator, receiver
I6L38_17260	COG0477	Major facilitator Superfamily
I6L38_17275	COG0312	modulator of DNA gyrase
I6L38_17280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L38_17295	COG3164	Protein of unknown function
I6L38_17300	COG1530	ribonuclease E activity
I6L38_17305	COG0424	maF-like protein
I6L38_17310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L38_17315	COG1792	Involved in formation and maintenance of cell shape
I6L38_17320	COG1077	Cell shape determining protein MreB Mrl
I6L38_17345	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6L38_17350	COG2165	general secretion pathway protein
I6L38_17355	COG2165	general secretion pathway protein
I6L38_17365	COG1459	type II secretion system
I6L38_17370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L38_17415	COG2199	diguanylate cyclase activity
I6L38_17415	COG2200	EAL domain
I6L38_17420	COG2200	EAL domain
I6L38_17425	COG0387	Pfam Sodium calcium exchanger
I6L38_17430	COG2986	histidine ammonia-lyase
I6L38_17435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L38_17440	COG0010	Belongs to the arginase family
I6L38_17445	COG1228	amidohydrolase
I6L38_17450	COG2188	Transcriptional regulator
I6L38_17455	COG0288	reversible hydration of carbon dioxide
I6L38_17465	COG2177	Part of the ABC transporter FtsEX involved in
I6L38_17470	COG2884	Cell division ATP-binding protein ftsE
I6L38_17475	COG0552	protein localization to endoplasmic reticulum
I6L38_17480	COG0742	ribosomal rna small subunit methyltransferase
I6L38_17505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L38_17515	COG0741	lytic transglycosylase activity
I6L38_17525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L38_17535	COG2095	MarC family integral membrane protein
I6L38_17545	COG1301	dicarboxylic acid transport
I6L38_17570	COG3714	YhhN family
I6L38_17585	COG2358	TRAP transporter, solute receptor (TAXI family
I6L38_17590	COG1770	oligopeptidase
I6L38_17605	COG4221	oxidoreductase activity
I6L38_17610	COG0583	DNA-binding transcription factor activity
I6L38_17615	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L38_17665	COG0203	ribosomal protein L17
I6L38_17670	COG0202	RNA polymerase activity
I6L38_17675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L38_17680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L38_17685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L38_17690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L38_17695	COG0201	protein transport
I6L38_17700	COG0200	Binds to the 23S rRNA
I6L38_17705	COG1841	ribosomal large subunit assembly
I6L38_17710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L38_17715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L38_17720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L38_17725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L38_17730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L38_17735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L38_17740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L38_17745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L38_17750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L38_17755	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L38_17760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L38_17765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L38_17770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L38_17775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L38_17780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L38_17785	COG0089	rRNA binding
I6L38_17790	COG0088	Forms part of the polypeptide exit tunnel
I6L38_17795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L38_17800	COG0051	transcription antitermination factor activity, RNA binding
I6L38_17820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L38_17825	COG2183	response to ionizing radiation
I6L38_17845	COG0596	Alpha beta hydrolase
I6L38_17850	COG1040	competence protein
I6L38_17855	COG0316	Belongs to the HesB IscA family
I6L38_17855	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L38_17860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L38_17865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L38_17870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L38_17875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L38_17880	COG4942	peptidase
I6L38_17890	COG1609	Transcriptional regulator
I6L38_17895	COG0800	Aldolase
I6L38_17900	COG0129	dihydroxy-acid dehydratase activity
I6L38_17905	COG3265	gluconokinase activity
I6L38_17910	COG2610	gluconate transmembrane transporter activity
I6L38_17915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L38_17920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L38_17930	COG0456	acetyltransferase
I6L38_17940	COG1490	D-aminoacyl-tRNA deacylase activity
I6L38_17945	COG1295	ribonuclease BN
I6L38_17950	COG1217	gtp-binding protein TYPA
I6L38_17955	COG0174	glutamine synthetase
I6L38_17965	COG3852	Histidine kinase
I6L38_17970	COG2204	response regulator
I6L38_17975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L38_17990	COG3078	GTPase activator activity
I6L38_18000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L38_18010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L38_18015	COG0408	coproporphyrinogen oxidase activity
I6L38_18020	COG0009	L-threonylcarbamoyladenylate synthase
I6L38_18030	COG0551	DNA topoisomerase type I activity
I6L38_18035	COG2922	Belongs to the Smg family
I6L38_18040	COG0758	DNA mediated transformation
I6L38_18050	COG0242	peptide deformylase activity
I6L38_18055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L38_18060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L38_18060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L38_18065	COG0569	domain protein
I6L38_18070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L38_18075	COG1322	Protein conserved in bacteria
I6L38_18095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L38_18100	COG0686	Belongs to the AlaDH PNT family
I6L38_18105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L38_18105	COG0519	Catalyzes the synthesis of GMP from XMP
I6L38_18115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L38_18120	COG1396	sequence-specific DNA binding
I6L38_18125	COG1012	belongs to the aldehyde dehydrogenase family
I6L38_18135	COG2962	Rard protein
I6L38_18145	COG1280	lysine exporter protein (LysE YggA)
I6L38_18155	COG2391	methyltransferase activity
I6L38_18160	COG1280	lysine exporter protein (LysE YggA)
I6L38_18195	COG3161	chorismate lyase activity
I6L38_18225	COG0583	DNA-binding transcription factor activity
I6L38_18230	COG1943	Transposase
I6L38_18250	COG0210	DNA helicase
I6L38_18255	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L38_18260	COG3845	ABC transporter
I6L38_18265	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L38_18270	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L38_18275	COG0583	DNA-binding transcription factor activity
I6L38_18295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L38_18300	COG0385	Bile acid
I6L38_18305	COG0531	amino acid
I6L38_18310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L38_18315	COG0531	amino acid
I6L38_18320	COG2731	YhcH YjgK YiaL family protein
I6L38_18325	COG3250	beta-galactosidase activity
I6L38_18330	COG1609	Transcriptional regulator
I6L38_18365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L38_18370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L38_18370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L38_18375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L38_18380	COG3074	FtsZ-dependent cytokinesis
I6L38_18390	COG1045	serine acetyltransferase
I6L38_18400	COG0745	RESPONSE REGULATOR receiver
I6L38_18405	COG2205	protein histidine kinase activity
I6L38_18410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L38_18415	COG0534	Mate efflux family protein
I6L38_18430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L38_18435	COG2937	Belongs to the GPAT DAPAT family
I6L38_18440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L38_18445	COG3161	chorismate lyase activity
I6L38_18450	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L38_18465	COG0604	alcohol dehydrogenase
I6L38_18470	COG1609	Transcriptional regulator
I6L38_18490	COG1519	Transferase
I6L38_18495	COG0859	PFAM glycosyl transferase family 9
I6L38_18500	COG0463	Glycosyl transferase, family 2
I6L38_18505	COG0859	PFAM glycosyl transferase family 9
I6L38_18510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L38_18515	COG2990	Protein conserved in bacteria
I6L38_18520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L38_18530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L38_18535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L38_18540	COG2003	Belongs to the UPF0758 family
I6L38_18545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L38_18550	COG0756	dUTP diphosphatase activity
I6L38_18555	COG1309	transcriptional regulator
I6L38_18560	COG0668	transmembrane transport
I6L38_18570	COG0166	Belongs to the GPI family
I6L38_18575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L38_18580	COG0583	DNA-binding transcription factor activity
I6L38_18595	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L38_18595	COG1042	CoA-binding domain protein
I6L38_18595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L38_18625	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L38_18630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L38_18635	COG1739	Uncharacterized protein family UPF0029
I6L38_18640	COG0006	proline dipeptidase activity
I6L38_18645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L38_18650	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L38_18650	COG1024	Enoyl-CoA hydratase
I6L38_18655	COG0183	Belongs to the thiolase family
I6L38_18680	COG0425	Belongs to the sulfur carrier protein TusA family
I6L38_18685	COG0251	oxidation-reduction process
I6L38_18695	COG2885	chlorophyll binding
I6L38_18705	COG2818	Glycosylase
I6L38_18710	COG0752	glycyl-tRNA synthetase alpha subunit
I6L38_18715	COG0751	glycine-tRNA ligase activity
I6L38_18730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L38_18755	COG0814	amino acid
I6L38_18760	COG0348	domain, Protein
I6L38_18765	COG2188	Transcriptional regulator
I6L38_18780	COG1609	Transcriptional regulator
I6L38_18820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L38_18845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L38_18860	COG3118	belongs to the thioredoxin family
I6L38_18865	COG0513	Belongs to the DEAD box helicase family
I6L38_18870	COG0248	Ppx GppA phosphatase
I6L38_18885	COG0742	ribosomal rna small subunit methyltransferase
I6L38_18890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_18910	COG0084	hydrolase, TatD family'
I6L38_18915	COG0805	protein transport
I6L38_18920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L38_18930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L38_18935	COG3165	ubiquinone biosynthetic process from chorismate
I6L38_18945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L38_18950	COG0402	S-adenosylhomocysteine deaminase activity
I6L38_18995	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L38_19000	COG0848	biopolymer transport protein
I6L38_19005	COG0811	peptide transport
I6L38_19010	COG0811	peptide transport
I6L38_19020	COG2771	luxR family
I6L38_19025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L38_19030	COG1349	DNA-binding transcription factor activity
I6L38_19035	COG0745	RESPONSE REGULATOR receiver
I6L38_19040	COG2205	protein histidine kinase activity
I6L38_19050	COG4452	Inner membrane protein CreD
I6L38_19055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L38_19060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L38_19065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L38_19070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L38_19075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L38_19080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L38_19085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L38_19095	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L38_19105	COG1475	DNA binding
I6L38_19110	COG1192	Involved in chromosome partitioning
I6L38_19115	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L38_19120	COG0445	tRNA wobble uridine modification
I6L38_19125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L38_19130	COG4774	siderophore transport
I6L38_19135	COG4615	Cyclic peptide transporter
I6L38_19140	COG1120	ATPase activity
I6L38_19150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L38_19155	COG3550	peptidyl-serine autophosphorylation
I6L38_19205	COG1695	Transcriptional regulator
I6L38_19225	COG3173	Aminoglycoside phosphotransferase
I6L38_19235	COG0488	(ABC) transporter
I6L38_19240	COG3173	Aminoglycoside phosphotransferase
I6L38_19315	COG4974	Belongs to the 'phage' integrase family
I6L38_19320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L38_19325	COG0706	membrane insertase activity
I6L38_19330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L38_19335	COG0594	ribonuclease P activity
I6L38_19340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L38_19345	COG1126	abc transporter atp-binding protein
I6L38_19360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L38_19365	COG0592	DNA-directed DNA polymerase activity
I6L38_19385	COG2378	regulation of single-species biofilm formation
I6L38_19390	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L38_19395	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L38_19400	COG3977	Valine--pyruvate aminotransferase
I6L38_19415	COG2814	Major facilitator Superfamily
I6L38_19420	COG0745	RESPONSE REGULATOR receiver
I6L38_19425	COG2205	protein histidine kinase activity
I6L38_19450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L38_19455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L38_19455	COG4191	Histidine kinase
I6L38_19460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L38_19465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L38_19470	COG1309	transcriptional regulator
I6L38_19505	COG2271	Major facilitator Superfamily
I6L38_19525	COG0561	phosphatase activity
I6L38_19530	COG2267	carboxylic ester hydrolase activity
I6L38_19540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L38_19545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L38_19550	COG1758	RNA polymerase activity
I6L38_19560	COG0859	PFAM glycosyl transferase family 9
I6L38_19565	COG3642	lipopolysaccharide core region biosynthetic process
I6L38_19605	COG0589	response to stress
I6L38_19610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L38_19620	COG1528	Iron-storage protein
I6L38_19625	COG2081	HI0933 family
I6L38_19630	COG2223	nitrite transmembrane transporter activity
I6L38_19640	COG3275	phosphorelay sensor kinase activity
I6L38_19645	COG3279	Response regulator of the LytR AlgR family
I6L38_19650	COG2223	nitrite transmembrane transporter activity
I6L38_19655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L38_19660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L38_19675	COG0583	DNA-binding transcription factor activity
I6L38_19685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L38_19720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L38_19725	COG2166	iron-sulfur cluster assembly
I6L38_19730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L38_19740	COG5001	Diguanylate cyclase
I6L38_19740	COG3300	MHYT domain
I6L38_19745	COG3245	cytochrome
I6L38_19750	COG1063	alcohol dehydrogenase
I6L38_19765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L38_19780	COG3306	glycosyltransferase involved in LPS biosynthesis
I6L38_19800	COG4774	siderophore transport
I6L38_19805	COG4607	ABC-type enterochelin transport system periplasmic component
I6L38_19810	COG4604	ABC transporter, ATP-binding protein
I6L38_19815	COG4605	iron ion homeostasis
I6L38_19820	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L38_19825	COG1132	(ABC) transporter
I6L38_19830	COG2375	cellular response to nickel ion
I6L38_19830	COG1132	(ABC) transporter
I6L38_19840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L38_19850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L38_19850	COG2226	methyltransferase
I6L38_19850	COG3433	isochorismatase activity
I6L38_19865	COG1561	YicC-like family, N-terminal region
I6L38_19870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L38_19875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L38_19885	COG0789	Transcriptional regulator
I6L38_19890	COG2203	Gaf domain
I6L38_19890	COG3706	GGDEF domain
I6L38_19890	COG4251	negative regulation of phosphorylation
I6L38_19890	COG5001	Diguanylate cyclase
I6L38_19895	COG3084	Protein conserved in bacteria
I6L38_19905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L38_19910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L38_19915	COG3639	organic phosphonate transmembrane transporter activity
I6L38_19920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6L38_19925	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L38_19935	COG1335	isochorismatase
I6L38_19945	COG1683	Conserved Protein
I6L38_19950	COG0204	Acyl-transferase
I6L38_19955	COG0204	Acyl-transferase
I6L38_19960	COG0606	chelatase, subunit chli
I6L38_19970	COG3978	acetolactate synthase activity
I6L38_19980	COG0129	dihydroxy-acid dehydratase activity
I6L38_20010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L38_20015	COG0254	rRNA binding
I6L38_20020	COG0702	epimerase
I6L38_20025	COG0281	malic enzyme
I6L38_20035	COG2205	protein histidine kinase activity
I6L38_20040	COG0745	RESPONSE REGULATOR receiver
I6L38_20045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L38_20080	COG4310	Domain of unknown function (DUF2172)
I6L38_20100	COG2089	acid synthase
I6L38_20110	COG1083	cytidylyl-transferase
I6L38_20125	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_20130	COG0318	PFAM AMP-dependent synthetase and ligase
I6L38_20145	COG1215	transferase activity, transferring glycosyl groups
I6L38_20150	COG1442	glycosyl transferase family 8
I6L38_20190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L38_20200	COG4106	trans-aconitate 2-methyltransferase activity
I6L38_20215	COG0529	Catalyzes the synthesis of activated sulfate
I6L38_20225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L38_20230	COG3848	Pyruvate phosphate dikinase
I6L38_20230	COG0574	Belongs to the PEP-utilizing enzyme family
I6L38_20235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L38_20240	COG1213	nucleotidyl transferase
I6L38_20245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L38_20250	COG1086	Polysaccharide biosynthesis protein
I6L38_20255	COG0366	Alpha amylase catalytic
I6L38_20265	COG3187	Heat shock protein
I6L38_20270	COG0443	Heat shock 70 kDa protein
I6L38_20275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L38_20280	COG3045	CreA protein
I6L38_20300	COG0174	glutamine synthetase
I6L38_20320	COG3842	ATPase activity
I6L38_20325	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L38_20330	COG1177	transmembrane transport
I6L38_20335	COG2258	MOSC domain
I6L38_20350	COG2050	protein possibly involved in aromatic compounds catabolism
I6L38_20355	COG0514	ATP-dependent DNA helicase (RecQ)
I6L38_20365	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L38_20375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L38_20380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L38_20390	COG2239	Acts as a magnesium transporter
I6L38_20395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L38_20395	COG1648	precorrin-2 dehydrogenase activity
I6L38_20400	COG2116	formate transmembrane transporter activity
I6L38_20410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L38_20420	COG0477	Major facilitator Superfamily
I6L38_20425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L38_20430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L38_20450	COG1595	DNA-templated transcription, initiation
I6L38_20455	COG3806	Anti-sigma factor
I6L38_20460	COG1968	undecaprenyl-diphosphatase activity
I6L38_20465	COG0667	Aldo Keto reductase
I6L38_20470	COG2017	converts alpha-aldose to the beta-anomer
I6L38_20475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L38_20485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L38_20490	COG1609	Transcriptional regulator
I6L38_20495	COG3250	beta-galactosidase activity
I6L38_20545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L38_20550	COG1288	antiporter activity
I6L38_20555	COG1438	arginine binding
I6L38_20560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L38_20565	COG0540	Belongs to the ATCase OTCase family
I6L38_20585	COG0688	phosphatidylethanolamine metabolic process
I6L38_20605	COG2207	Transcriptional regulator
I6L38_20610	COG1979	alcohol dehydrogenase
I6L38_20615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L38_20620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L38_20630	COG3681	Belongs to the UPF0597 family
I6L38_20640	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L38_20645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L38_20650	COG0564	pseudouridine synthase activity
I6L38_20660	COG0542	response to heat
I6L38_20665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L38_20670	COG2502	aspartate--ammonia ligase
I6L38_20675	COG1522	sequence-specific DNA binding
I6L38_20685	COG5413	integral membrane protein
I6L38_20695	COG1028	Short-chain dehydrogenase reductase Sdr
I6L38_20710	COG2205	protein histidine kinase activity
I6L38_20720	COG2204	response regulator
I6L38_20735	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6L38_20765	COG0243	molybdopterin cofactor binding
I6L38_20770	COG3005	denitrification pathway
I6L38_20775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L38_20795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L38_20800	COG0569	domain protein
I6L38_20805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L38_20830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L38_20845	COG0250	Participates in transcription elongation, termination and antitermination
I6L38_20850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L38_20855	COG0081	regulation of translation
I6L38_20860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L38_20865	COG0222	ribosome binding
I6L38_20870	COG0085	RNA polymerase activity
I6L38_20875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L38_20880	COG2964	Protein conserved in bacteria
I6L38_20885	COG0251	oxidation-reduction process
I6L38_20900	COG2168	tRNA wobble position uridine thiolation
I6L38_20905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L38_20910	COG0049	tRNA binding
I6L38_20915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L38_20920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L38_20925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L38_20960	COG2252	PERMEase
I6L38_20965	COG2376	Dihydroxyacetone kinase
I6L38_20970	COG1461	Dihydroxyacetone kinase
I6L38_20985	COG3284	Transcriptional regulator
I6L38_20990	COG4221	oxidoreductase activity
I6L38_20995	COG0628	permease
I6L38_21000	COG0671	phosphoesterase, PA-phosphatase related
I6L38_21025	COG1247	-acetyltransferase
I6L38_21045	COG3706	GGDEF domain
I6L38_21055	COG3842	ATPase activity
I6L38_21065	COG1175	transmembrane transport
I6L38_21090	COG0583	DNA-binding transcription factor activity
I6L38_21100	COG1741	Belongs to the pirin family
I6L38_21105	COG2259	Doxx family
I6L38_21110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L38_21115	COG1074	ATP-dependent DNA helicase activity
I6L38_21120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L38_21135	COG0583	DNA-binding transcription factor activity
I6L38_21145	COG0346	lactoylglutathione lyase activity
I6L38_21190	COG2203	Gaf domain
I6L38_21190	COG3706	GGDEF domain
I6L38_21190	COG4251	negative regulation of phosphorylation
I6L38_21190	COG5001	Diguanylate cyclase
I6L38_21195	COG4771	TonB-dependent receptor
I6L38_21225	COG2197	response regulator
I6L38_21230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L38_21240	COG3047	cAMP biosynthetic process
I6L38_21245	COG0840	transmembrane signaling receptor activity
I6L38_21270	COG3135	benzoate transporter
I6L38_21275	COG1396	sequence-specific DNA binding
I6L38_21305	COG2926	Belongs to the UPF0265 family
I6L38_21315	COG3028	Belongs to the UPF0307 family
I6L38_21320	COG0312	modulator of DNA gyrase
I6L38_21325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L38_21330	COG5007	Belongs to the BolA IbaG family
I6L38_21340	COG2854	intermembrane phospholipid transfer
I6L38_21345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L38_21350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L38_21355	COG1127	ABC transporter
I6L38_21360	COG0517	IMP dehydrogenase activity
I6L38_21360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L38_21365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L38_21370	COG3117	lipopolysaccharide transmembrane transporter activity
I6L38_21375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L38_21380	COG1137	ATPase activity
I6L38_21385	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L38_21395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_21400	COG1660	Displays ATPase and GTPase activities
I6L38_21405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_21410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L38_21410	COG3711	transcriptional antiterminator
I6L38_21425	COG3964	amidohydrolase
I6L38_21455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L38_21460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L38_21470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L38_21475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L38_21480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L38_21485	COG0723	plastoquinol--plastocyanin reductase activity
I6L38_21490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L38_21495	COG2857	Cytochrome c1
I6L38_21500	COG0625	glutathione transferase activity
I6L38_21505	COG2969	positive regulation of protein catabolic process
I6L38_21510	COG2823	Periplasmic or secreted lipoprotein
I6L38_21515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L38_21520	COG0792	nuclease activity
I6L38_21525	COG3107	peptidoglycan biosynthetic process
I6L38_21530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L38_21540	COG2001	Belongs to the MraZ family
I6L38_21545	COG0275	rRNA processing
I6L38_21550	COG3116	cell division
I6L38_21555	COG0768	penicillin binding
I6L38_21565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L38_21570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L38_21575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L38_21580	COG0772	Belongs to the SEDS family
I6L38_21585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L38_21590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L38_21595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L38_21600	COG0849	cell division
I6L38_21605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L38_21610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L38_21620	COG0653	protein targeting
I6L38_21630	COG0494	nUDIX hydrolase
I6L38_21635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L38_21640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L38_21655	COG1459	type II secretion system
I6L38_21660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L38_21685	COG2186	Transcriptional regulator
I6L38_21690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L38_21695	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L38_21700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L38_21710	COG0840	transmembrane signaling receptor activity
I6L38_21715	COG0840	transmembrane signaling receptor activity
I6L38_21720	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L38_21725	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L38_21730	COG2200	EAL domain
I6L38_21740	COG1280	lysine exporter protein (LysE YggA)
I6L38_21750	COG0523	cobalamin synthesis protein
I6L38_21755	COG0477	Major facilitator Superfamily
I6L38_21770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L38_21775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L38_21810	COG3314	Sporulation integral membrane protein YlbJ
I6L38_21815	COG0835	chemotaxis
I6L38_21815	COG0784	Response regulator, receiver
I6L38_21825	COG1444	tRNA N-acetyltransferase activity
I6L38_21850	COG1803	Methylglyoxal synthase
I6L38_21865	COG0252	asparaginase activity
I6L38_21880	COG1609	Transcriptional regulator
I6L38_21885	COG1263	PTS System
I6L38_21885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L38_21890	COG0366	Alpha amylase catalytic
I6L38_21895	COG0110	maltose O-acetyltransferase activity
I6L38_21920	COG1012	belongs to the aldehyde dehydrogenase family
I6L38_21925	COG1177	transmembrane transport
I6L38_21930	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L38_21935	COG3842	ATPase activity
I6L38_21940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L38_21945	COG0583	DNA-binding transcription factor activity
I6L38_21950	COG1757	Na H antiporter
I6L38_21990	COG0297	glycogen (starch) synthase activity
I6L38_21995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L38_22000	COG2813	Specifically methylates the guanine in position
I6L38_22005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L38_22010	COG2203	Gaf domain
I6L38_22010	COG3706	GGDEF domain
I6L38_22010	COG4251	negative regulation of phosphorylation
I6L38_22010	COG5001	Diguanylate cyclase
I6L38_22020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L38_22030	COG2995	paraquat-inducible protein a
I6L38_22035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L38_22035	COG3008	intermembrane lipid transfer
I6L38_22040	COG3009	Protein conserved in bacteria
I6L38_22045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L38_22045	COG2885	chlorophyll binding
I6L38_22055	COG3240	lipase activity
I6L38_22060	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L38_22070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L38_22075	COG1194	a g-specific adenine glycosylase
I6L38_22085	COG3409	Peptidoglycan-binding domain 1 protein
I6L38_22085	COG3267	Type II secretory pathway component ExeA
I6L38_22090	COG0617	tRNA 3'-terminal CCA addition
I6L38_22105	COG1346	cytolysis
I6L38_22110	COG1380	Effector of murein hydrolase LrgA
I6L38_22115	COG0583	DNA-binding transcription factor activity
I6L38_22145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L38_22150	COG0306	phosphate transporter
I6L38_22155	COG1392	Phosphate transport regulator
I6L38_22170	COG1560	Kdo2-lipid A biosynthetic process
I6L38_22175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L38_22175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L38_22180	COG1538	Outer membrane efflux protein
I6L38_22185	COG0494	nUDIX hydrolase
I6L38_22190	COG3151	Protein conserved in bacteria
I6L38_22200	COG3150	esterase
I6L38_22205	COG1051	belongs to the nudix hydrolase family
I6L38_22220	COG1566	PFAM secretion protein HlyD family protein
I6L38_22225	COG1289	transmembrane transporter activity
I6L38_22250	COG0583	DNA-binding transcription factor activity
I6L38_22260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L38_22310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L38_22330	COG0204	Acyl-transferase
I6L38_22335	COG1842	Phage shock protein A
I6L38_22350	COG2827	Endonuclease containing a URI domain
I6L38_22360	COG2962	Rard protein
I6L38_22365	COG1573	uracil-dna glycosylase
I6L38_22370	COG0697	spore germination
I6L38_22375	COG0583	DNA-binding transcription factor activity
I6L38_22380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L38_22385	COG1121	(ABC) transporter
I6L38_22390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L38_22410	COG0739	heme binding
I6L38_22420	COG3068	Protein conserved in bacteria
I6L38_22440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L38_22470	COG1546	Belongs to the CinA family
I6L38_22475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L38_22480	COG2137	regulation of response to DNA damage stimulus
I6L38_22485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L38_22490	COG0527	aspartate kinase activity
I6L38_22495	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L38_22530	COG1686	Belongs to the peptidase S11 family
I6L38_22535	COG0586	Pfam SNARE associated Golgi protein
I6L38_22540	COG1253	flavin adenine dinucleotide binding